diff --git a/instrumentation/opentelemetry-instrumentation-mysql/CHANGELOG.md b/instrumentation/opentelemetry-instrumentation-mysql/CHANGELOG.md
index 8912788b2f05..f024cf695991 100644
--- a/instrumentation/opentelemetry-instrumentation-mysql/CHANGELOG.md
+++ b/instrumentation/opentelemetry-instrumentation-mysql/CHANGELOG.md
@@ -2,6 +2,9 @@
 
 ## Unreleased
 
+- Drop support for Python 3.4
+  ([#1099](https://github.com/open-telemetry/opentelemetry-python/pull/1099))
+
 ## Version 0.12b0
 
 Released 2020-08-14
diff --git a/instrumentation/opentelemetry-instrumentation-mysql/setup.cfg b/instrumentation/opentelemetry-instrumentation-mysql/setup.cfg
index aed70b99f129..cc0b435c7466 100644
--- a/instrumentation/opentelemetry-instrumentation-mysql/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-mysql/setup.cfg
@@ -28,14 +28,13 @@ classifiers =
     License :: OSI Approved :: Apache Software License
     Programming Language :: Python
     Programming Language :: Python :: 3
-    Programming Language :: Python :: 3.4
     Programming Language :: Python :: 3.5
     Programming Language :: Python :: 3.6
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
 
 [options]
-python_requires = >=3.4
+python_requires = >=3.5
 package_dir=
     =src
 packages=find_namespace: