diff --git a/lib/zlib.js b/lib/zlib.js
index c57e83661bfa9b..80ffb962b38c6c 100644
--- a/lib/zlib.js
+++ b/lib/zlib.js
@@ -472,6 +472,11 @@ function processCallback() {
     return;
   }
 
+  if (self.destroyed) {
+    this.buffer = null;
+    return;
+  }
+
   var availOutAfter = state[0];
   var availInAfter = state[1];
 
diff --git a/test/parallel/test-zlib-destroy-pipe.js b/test/parallel/test-zlib-destroy-pipe.js
new file mode 100644
index 00000000000000..38b8a5b4926e51
--- /dev/null
+++ b/test/parallel/test-zlib-destroy-pipe.js
@@ -0,0 +1,21 @@
+'use strict';
+
+const common = require('../common');
+const zlib = require('zlib');
+const { Writable } = require('stream');
+
+// verify that the zlib transform does not error in case
+// it is destroyed with data still in flight
+
+const ts = zlib.createGzip();
+
+const ws = new Writable({
+  write: common.mustCall((chunk, enc, cb) => {
+    setImmediate(cb);
+    ts.destroy();
+  })
+});
+
+const buf = Buffer.allocUnsafe(1024 * 1024 * 20);
+ts.end(buf);
+ts.pipe(ws);