diff --git a/CHANGELOG.md b/CHANGELOG.md
index c231616998..127ba7e12e 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -23,6 +23,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - [#1552](https://github.com/nf-core/sarek/pull/1552) - Update samtools to v1.20
 - [#1545](https://github.com/nf-core/sarek/pull/1545) - Update modules
 - [#1553](https://github.com/nf-core/sarek/pull/1553) - Update bcftools to v1.20
+- [#1557](https://github.com/nf-core/sarek/pull/1557) - Update ENSEMBLVEP cache to 111
 
 ### Fixed
 
diff --git a/conf/igenomes.config b/conf/igenomes.config
index a3f57e6d7e..af199c5e6d 100644
--- a/conf/igenomes.config
+++ b/conf/igenomes.config
@@ -75,7 +75,7 @@ params {
             sentieon_dnascope_model = "${params.igenomes_base}/Homo_sapiens/GATK/GRCh38/Annotation/Sentieon/SentieonDNAscopeModel1.1.model"
             snpeff_db               = '105'
             snpeff_genome           = 'GRCh38'
-            vep_cache_version       = '110'
+            vep_cache_version       = '111'
             vep_genome              = 'GRCh38'
             vep_species             = 'homo_sapiens'
         }
@@ -336,7 +336,7 @@ params {
             ngscheckmate_bed        = "${params.igenomes_base}/genomics/homo_sapiens/genome/chr21/germlineresources/SNP_GRCh38_hg38_wChr.bed"
             snpeff_db               = '105'
             snpeff_genome           = 'WBcel235'
-            vep_cache_version       = '110'
+            vep_cache_version       = '111'
             vep_genome              = 'WBcel235'
             vep_species             = 'caenorhabditis_elegans'
         }