diff --git a/CHANGELOG.md b/CHANGELOG.md
index 7e06350e8..a45025384 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -113,6 +113,7 @@ Thank you to everyone else that has contributed by reporting bugs, enhancements
 - [PR #1352](https://github.com/nf-core/rnaseq/pull/1352) - Assorted fixes to MultiQC usage
 - [PR #1355](https://github.com/nf-core/rnaseq/pull/1355) - Make all curves on subway map better looking, and all lines now have the same width
 - [PR #1357](https://github.com/nf-core/rnaseq/pull/1357) - Fix anchor issue in multiqc
+- [PR #1358](https://github.com/nf-core/rnaseq/pull/1358) - Update test profiles to restore a static URI for megatests
 
 ### Parameters
 
diff --git a/conf/test.config b/conf/test.config
index 84e3bdc8a..f7a9fca91 100644
--- a/conf/test.config
+++ b/conf/test.config
@@ -20,19 +20,19 @@ params {
     max_time   = '6.h'
 
     // Input data
-    input              = params.pipelines_testdata_base_path + 'samplesheet/v3.10/samplesheet_test.csv'
+    input              = 'https://raw.githubusercontent.com/nf-core/test-datasets/626c8fab639062eade4b10747e919341cbf9b41a/samplesheet/v3.10/samplesheet_test.csv'
 
     // Genome references
-    fasta              = params.pipelines_testdata_base_path + 'reference/genome.fasta'
-    gtf                = params.pipelines_testdata_base_path + 'reference/genes_with_empty_tid.gtf.gz'
-    gff                = params.pipelines_testdata_base_path + 'reference/genes.gff.gz'
-    transcript_fasta   = params.pipelines_testdata_base_path + 'reference/transcriptome.fasta'
-    additional_fasta   = params.pipelines_testdata_base_path + 'reference/gfp.fa.gz'
-
-    bbsplit_fasta_list = params.pipelines_testdata_base_path + 'reference/bbsplit_fasta_list.txt'
-    hisat2_index       = params.pipelines_testdata_base_path + 'reference/hisat2.tar.gz'
-    salmon_index       = params.pipelines_testdata_base_path + 'reference/salmon.tar.gz'
-    rsem_index         = params.pipelines_testdata_base_path + 'reference/rsem.tar.gz'
+    fasta              = 'https://raw.githubusercontent.com/nf-core/test-datasets/626c8fab639062eade4b10747e919341cbf9b41a/reference/genome.fasta'
+    gtf                = 'https://raw.githubusercontent.com/nf-core/test-datasets/626c8fab639062eade4b10747e919341cbf9b41a/reference/genes_with_empty_tid.gtf.gz'
+    gff                = 'https://raw.githubusercontent.com/nf-core/test-datasets/626c8fab639062eade4b10747e919341cbf9b41a/reference/genes.gff.gz'
+    transcript_fasta   = 'https://raw.githubusercontent.com/nf-core/test-datasets/626c8fab639062eade4b10747e919341cbf9b41a/reference/transcriptome.fasta'
+    additional_fasta   = 'https://raw.githubusercontent.com/nf-core/test-datasets/626c8fab639062eade4b10747e919341cbf9b41a/reference/gfp.fa.gz'
+
+    bbsplit_fasta_list = 'https://raw.githubusercontent.com/nf-core/test-datasets/626c8fab639062eade4b10747e919341cbf9b41a/reference/bbsplit_fasta_list.txt'
+    hisat2_index       = 'https://raw.githubusercontent.com/nf-core/test-datasets/626c8fab639062eade4b10747e919341cbf9b41a/reference/hisat2.tar.gz'
+    salmon_index       = 'https://raw.githubusercontent.com/nf-core/test-datasets/626c8fab639062eade4b10747e919341cbf9b41a/reference/salmon.tar.gz'
+    rsem_index         = 'https://raw.githubusercontent.com/nf-core/test-datasets/626c8fab639062eade4b10747e919341cbf9b41a/reference/rsem.tar.gz'
 
     // Other parameters
     skip_bbsplit        = false
diff --git a/conf/test_full.config b/conf/test_full.config
index 49ce794d3..320b8156f 100644
--- a/conf/test_full.config
+++ b/conf/test_full.config
@@ -15,7 +15,7 @@ params {
     config_profile_description = 'Full test dataset to check pipeline function'
 
     // Parameters for full-size test
-    input          = params.pipelines_testdata_base_path + 'samplesheet/v3.10/samplesheet_full.csv'
+    input          = 'https://raw.githubusercontent.com/nf-core/test-datasets/626c8fab639062eade4b10747e919341cbf9b41a/samplesheet/v3.10/samplesheet_full.csv'
     genome         = 'GRCh37'
     pseudo_aligner = 'salmon'
 }