From 55b1ab9e49d5713ca2b4508cdcdc02ee60a19cee Mon Sep 17 00:00:00 2001 From: drpatelh Date: Thu, 2 Jul 2020 12:23:57 +0100 Subject: [PATCH 001/538] Bump version --- .github/workflows/ci.yml | 8 ++++---- CHANGELOG.md | 8 ++++++++ Dockerfile | 4 ++-- environment.yml | 2 +- nextflow.config | 4 ++-- 5 files changed, 17 insertions(+), 9 deletions(-) diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 6c65240bd..5cfe6711b 100755 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -35,13 +35,13 @@ jobs: - name: Build new docker image if: env.GIT_DIFF - run: docker build --no-cache . -t nfcore/chipseq:1.2.0 + run: docker build --no-cache . -t nfcore/chipseq:dev - name: Pull docker image if: ${{ !env.GIT_DIFF }} run: | docker pull nfcore/chipseq:dev - docker tag nfcore/chipseq:dev nfcore/chipseq:1.2.0 + docker tag nfcore/chipseq:dev nfcore/chipseq:dev - name: Install Nextflow run: | @@ -75,13 +75,13 @@ jobs: - name: Build new docker image if: env.GIT_DIFF - run: docker build --no-cache . -t nfcore/chipseq:1.2.0 + run: docker build --no-cache . -t nfcore/chipseq:dev - name: Pull docker image if: ${{ !env.GIT_DIFF }} run: | docker pull nfcore/chipseq:dev - docker tag nfcore/chipseq:dev nfcore/chipseq:1.2.0 + docker tag nfcore/chipseq:dev nfcore/chipseq:dev - name: Install Nextflow run: | diff --git a/CHANGELOG.md b/CHANGELOG.md index aafc386f0..c33552316 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -3,6 +3,14 @@ The format is based on [Keep a Changelog](http://keepachangelog.com/en/1.0.0/) and this project adheres to [Semantic Versioning](http://semver.org/spec/v2.0.0.html). +## [Unpublished Version / DEV] + +### `Added` + +### `Fixed` + +### `Dependencies` + ## [1.2.0] - 2020-07-02 ### `Added` diff --git a/Dockerfile b/Dockerfile index 0628abe4a..6b5f6538f 100644 --- a/Dockerfile +++ b/Dockerfile @@ -7,10 +7,10 @@ COPY environment.yml / RUN conda env create -f /environment.yml && conda clean -a # Add conda installation dir to PATH (instead of doing 'conda activate') -ENV PATH /opt/conda/envs/nf-core-chipseq-1.2.0/bin:$PATH +ENV PATH /opt/conda/envs/nf-core-chipseq-1.3.0dev/bin:$PATH # Dump the details of the installed packages to a file for posterity -RUN conda env export --name nf-core-chipseq-1.2.0 > nf-core-chipseq-1.2.0.yml +RUN conda env export --name nf-core-chipseq-1.3.0dev > nf-core-chipseq-1.3.0dev.yml # Instruct R processes to use these empty files instead of clashing with a local version RUN touch .Rprofile diff --git a/environment.yml b/environment.yml index 112077221..c7efd4d9b 100644 --- a/environment.yml +++ b/environment.yml @@ -1,6 +1,6 @@ # You can use this file to create a conda environment for this pipeline: # conda env create -f environment.yml -name: nf-core-chipseq-1.2.0 +name: nf-core-chipseq-1.3.0dev channels: - conda-forge - bioconda diff --git a/nextflow.config b/nextflow.config index 4e54affdf..2a22eb383 100644 --- a/nextflow.config +++ b/nextflow.config @@ -96,7 +96,7 @@ params { // Container slug. Stable releases should specify release tag! // Developmental code should specify :dev -process.container = 'nfcore/chipseq:1.2.0' +process.container = 'nfcore/chipseq:dev' // Load base.config by default for all pipelines includeConfig 'conf/base.config' @@ -169,7 +169,7 @@ manifest { description = 'ChIP-seq peak-calling and differential analysis pipeline.' mainScript = 'main.nf' nextflowVersion = '>=19.10.0' - version = '1.2.0' + version = '1.3.0dev' } // Function to ensure that resource requirements don't go beyond From 65f59566e5774363f6f7a8394f78ec50a2fa43c4 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 13 Jul 2020 17:15:01 +0100 Subject: [PATCH 002/538] Rename samplesheet --- bin/check_samplesheet.py | 191 +++++++++++++++++++++++++++++++++++++++ 1 file changed, 191 insertions(+) create mode 100755 bin/check_samplesheet.py diff --git a/bin/check_samplesheet.py b/bin/check_samplesheet.py new file mode 100755 index 000000000..921349ecb --- /dev/null +++ b/bin/check_samplesheet.py @@ -0,0 +1,191 @@ +#!/usr/bin/env python + +####################################################################### +####################################################################### +## Created on April 4th 2019 to check nf-core/chipseq design file +####################################################################### +####################################################################### + +import os +import sys +import argparse + +############################################ +############################################ +## PARSE ARGUMENTS +############################################ +############################################ + +Description = 'Reformat nf-core/chipseq samplesheet and check its contents.' +Epilog = "Example usage: python check_samplesheet.py " + +argParser = argparse.ArgumentParser(description=Description, epilog=Epilog) + +## REQUIRED PARAMETERS +argParser.add_argument('DESIGN_FILE', help="Input samplesheet/design file.") +argParser.add_argument('READ_MAPPING_FILE', help="Output design file containing sample ids and reads.") +argParser.add_argument('CONTROL_MAPPING_FILE', help="Output design file containing ip vs control mappings.") +args = argParser.parse_args() + +############################################ +############################################ +## MAIN FUNCTION +############################################ +############################################ + +def reformat_design(DesignFile,ReadMappingFile,ControlMappingFile): + + ERROR_STR = 'ERROR: Please check design file' + HEADER = ['group', 'replicate', 'fastq_1', 'fastq_2', 'antibody', 'control'] + + ## CHECK HEADER + fin = open(DesignFile,'r') + header = fin.readline().strip().split(',') + if header != HEADER: + print("{} header: {} != {}".format(ERROR_STR,','.join(header),','.join(HEADER))) + sys.exit(1) + + numColList = [] + sampleMappingDict = {} + antibodyDict = {} + while True: + line = fin.readline() + if line: + lspl = [x.strip() for x in line.strip().split(',')] + group,replicate,fastQFiles,antibody,control = lspl[0],lspl[1],[x for x in lspl[2:-2] if x],lspl[-2],lspl[-1] + + ## CHECK VALID NUMBER OF COLUMNS PER SAMPLE + numCols = len(lspl) + if numCols not in [6]: + print("{}: Invalid number of columns (should be 6)!\nLine: '{}'".format(ERROR_STR,line.strip())) + sys.exit(1) + numColList.append(numCols) + + ## CHECK GROUP ID DOESNT CONTAIN SPACES + if group.find(' ') != -1: + print("{}: Group id contains spaces!\nLine: '{}'".format(ERROR_STR,line.strip())) + sys.exit(1) + + ## CHECK REPLICATE COLUMN IS INTEGER + if not replicate.isdigit(): + print("{}: Replicate id not an integer!\nLine: '{}'".format(ERROR_STR,line.strip())) + sys.exit(1) + replicate = int(replicate) + + for fastq in fastQFiles: + ## CHECK FASTQ FILE EXTENSION + if fastq[-9:] != '.fastq.gz' and fastq[-6:] != '.fq.gz': + print("{}: FastQ file has incorrect extension (has to be '.fastq.gz' or 'fq.gz') - {}\nLine: '{}'".format(ERROR_STR,fastq,line.strip())) + sys.exit(1) + + ## CREATE GROUP MAPPING DICT = {GROUP_ID: {REPLICATE_ID:[[FASTQ_FILES]]} + if group not in sampleMappingDict: + sampleMappingDict[group] = {} + if replicate not in sampleMappingDict[group]: + sampleMappingDict[group][replicate] = [] + sampleMappingDict[group][replicate].append(fastQFiles) + + ## CHECK BOTH ANTIBODY AND CONTROL COLUMNS HAVE VALID VALUES + if antibody: + if antibody.find(' ') != -1: + print("{}: Antibody id contains spaces!\nLine: '{}'".format(ERROR_STR,line.strip())) + sys.exit(1) + if not control: + print("{}: both Antibody and Control must be specified!\nLine: '{}'".format(ERROR_STR,line.strip())) + sys.exit(1) + if control: + if control.find(' ') != -1: + print("{}: Control id contains spaces!\nLine: '{}'".format(ERROR_STR,line.strip())) + sys.exit(1) + if not antibody: + print("{}: both Antibody and Control must be specified!\nLine: '{}'".format(ERROR_STR,line.strip())) + sys.exit(1) + + ## CREATE ANTIBODY MAPPING CONTROL DICT + if antibody and control: + antibodyDict[group] = (antibody,control) + + else: + fin.close() + break + + ## CHECK IF DATA IS PAIRED-END OR SINGLE-END AND NOT A MIXTURE + if min(numColList) != max(numColList): + print("{}: Mixture of paired-end and single-end reads!".format(ERROR_STR)) + sys.exit(1) + + ## CHECK IF ANTIBODY AND CONTROL COLUMNS HAVE BEEN SPECIFIED AT LEAST ONCE + if len(antibodyDict) == 0: + print("{}: Antibody and Control must be specified at least once!".format(ERROR_STR)) + sys.exit(1) + + ## WRITE READ MAPPING FILE + antibodyGroupDict = {} + fout = open(ReadMappingFile,'w') + fout.write(','.join(['sample_id','fastq_1','fastq_2']) + '\n') + for group in sorted(sampleMappingDict.keys()): + + ## CHECK THAT REPLICATE IDS ARE IN FORMAT 1.. + uniq_rep_ids = set(sampleMappingDict[group].keys()) + if len(uniq_rep_ids) != max(uniq_rep_ids): + print("{}: Replicate IDs must start with 1..\nGroup: {}, Replicate IDs: {}".format(ERROR_STR,group,list(uniq_rep_ids))) + sys.exit(1) + + ## RECONSTRUCT LINE FOR SAMPLE IN DESIGN + for replicate in sorted(sampleMappingDict[group].keys()): + for idx in range(len(sampleMappingDict[group][replicate])): + fastQFiles = sampleMappingDict[group][replicate][idx] + + ## GET SAMPLE_ID,FASTQ_1,FASTQ_2 COLUMNS + sample_id = "{}_R{}_T{}".format(group,replicate,idx+1) + oList = [sample_id] + fastQFiles + if len(fastQFiles) == 1: + oList += [''] + fout.write(','.join(oList) + '\n') + + ## EXTRAPOLATE CONTROL COLUMN + if group in antibodyDict: + antibody,control = antibodyDict[group] + if control in sampleMappingDict.keys(): + control_id = "{}_R1".format(control) + if replicate in sampleMappingDict[control]: + control_id = "{}_R{}".format(control,replicate) + if antibody not in antibodyGroupDict: + antibodyGroupDict[antibody] = {} + if group not in antibodyGroupDict[antibody]: + antibodyGroupDict[antibody][group] = [] + antibodyList = [sample_id[:-3],control_id] + if not antibodyList in antibodyGroupDict[antibody][group]: + antibodyGroupDict[antibody][group].append(antibodyList) + else: + print("{}: Control id not a valid group\nControl id: {}, Valid Groups: {}".format(ERROR_STR,control,sorted(sampleMappingDict.keys()))) + sys.exit(1) + fout.close() + + ## WRITE SAMPLE TO CONTROL MAPPING FILE + fout = open(ControlMappingFile,'w') + fout.write(','.join(['sample_id','control_id','antibody','replicatesExist','multipleGroups']) + '\n') + for antibody in sorted(antibodyGroupDict.keys()): + repsExist = '0' + if max([len(x) for x in antibodyGroupDict[antibody].values()]) > 1: + repsExist = '1' + multipleGroups = '0' + if len(antibodyGroupDict[antibody].keys()) > 1: + multipleGroups = '1' + for group in sorted(antibodyGroupDict[antibody].keys()): + for antibodyList in antibodyGroupDict[antibody][group]: + fout.write(','.join(antibodyList+[antibody,repsExist,multipleGroups]) + '\n') + fout.close() + +############################################ +############################################ +## RUN FUNCTION +############################################ +############################################ + +reformat_design(DesignFile=args.DESIGN_FILE,ReadMappingFile=args.READ_MAPPING_FILE,ControlMappingFile=args.CONTROL_MAPPING_FILE) + +############################################ +############################################ +############################################ +############################################ From 456d7d7515bd2f689b0fce62909de8f9c81005cb Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 13 Jul 2020 17:15:13 +0100 Subject: [PATCH 003/538] Renamed --- bin/check_design.py | 191 -------------------------------------------- 1 file changed, 191 deletions(-) delete mode 100755 bin/check_design.py diff --git a/bin/check_design.py b/bin/check_design.py deleted file mode 100755 index 51a993753..000000000 --- a/bin/check_design.py +++ /dev/null @@ -1,191 +0,0 @@ -#!/usr/bin/env python - -####################################################################### -####################################################################### -## Created on April 4th 2019 to check nf-core/chipseq design file -####################################################################### -####################################################################### - -import os -import sys -import argparse - -############################################ -############################################ -## PARSE ARGUMENTS -############################################ -############################################ - -Description = 'Reformat nf-core/chipseq design file and check its contents.' -Epilog = """Example usage: python check_design.py """ - -argParser = argparse.ArgumentParser(description=Description, epilog=Epilog) - -## REQUIRED PARAMETERS -argParser.add_argument('DESIGN_FILE', help="Input design file.") -argParser.add_argument('READ_MAPPING_FILE', help="Output design file containing sample ids and reads.") -argParser.add_argument('CONTROL_MAPPING_FILE', help="Output design file containing ip vs control mappings.") -args = argParser.parse_args() - -############################################ -############################################ -## MAIN FUNCTION -############################################ -############################################ - -def reformat_design(DesignFile,ReadMappingFile,ControlMappingFile): - - ERROR_STR = 'ERROR: Please check design file' - HEADER = ['group', 'replicate', 'fastq_1', 'fastq_2', 'antibody', 'control'] - - ## CHECK HEADER - fin = open(DesignFile,'r') - header = fin.readline().strip().split(',') - if header != HEADER: - print("{} header: {} != {}".format(ERROR_STR,','.join(header),','.join(HEADER))) - sys.exit(1) - - numColList = [] - sampleMappingDict = {} - antibodyDict = {} - while True: - line = fin.readline() - if line: - lspl = [x.strip() for x in line.strip().split(',')] - group,replicate,fastQFiles,antibody,control = lspl[0],lspl[1],[x for x in lspl[2:-2] if x],lspl[-2],lspl[-1] - - ## CHECK VALID NUMBER OF COLUMNS PER SAMPLE - numCols = len(lspl) - if numCols not in [6]: - print("{}: Invalid number of columns (should be 6)!\nLine: '{}'".format(ERROR_STR,line.strip())) - sys.exit(1) - numColList.append(numCols) - - ## CHECK GROUP ID DOESNT CONTAIN SPACES - if group.find(' ') != -1: - print("{}: Group id contains spaces!\nLine: '{}'".format(ERROR_STR,line.strip())) - sys.exit(1) - - ## CHECK REPLICATE COLUMN IS INTEGER - if not replicate.isdigit(): - print("{}: Replicate id not an integer!\nLine: '{}'".format(ERROR_STR,line.strip())) - sys.exit(1) - replicate = int(replicate) - - for fastq in fastQFiles: - ## CHECK FASTQ FILE EXTENSION - if fastq[-9:] != '.fastq.gz' and fastq[-6:] != '.fq.gz': - print("{}: FastQ file has incorrect extension (has to be '.fastq.gz' or 'fq.gz') - {}\nLine: '{}'".format(ERROR_STR,fastq,line.strip())) - sys.exit(1) - - ## CREATE GROUP MAPPING DICT = {GROUP_ID: {REPLICATE_ID:[[FASTQ_FILES]]} - if group not in sampleMappingDict: - sampleMappingDict[group] = {} - if replicate not in sampleMappingDict[group]: - sampleMappingDict[group][replicate] = [] - sampleMappingDict[group][replicate].append(fastQFiles) - - ## CHECK BOTH ANTIBODY AND CONTROL COLUMNS HAVE VALID VALUES - if antibody: - if antibody.find(' ') != -1: - print("{}: Antibody id contains spaces!\nLine: '{}'".format(ERROR_STR,line.strip())) - sys.exit(1) - if not control: - print("{}: both Antibody and Control must be specified!\nLine: '{}'".format(ERROR_STR,line.strip())) - sys.exit(1) - if control: - if control.find(' ') != -1: - print("{}: Control id contains spaces!\nLine: '{}'".format(ERROR_STR,line.strip())) - sys.exit(1) - if not antibody: - print("{}: both Antibody and Control must be specified!\nLine: '{}'".format(ERROR_STR,line.strip())) - sys.exit(1) - - ## CREATE ANTIBODY MAPPING CONTROL DICT - if antibody and control: - antibodyDict[group] = (antibody,control) - - else: - fin.close() - break - - ## CHECK IF DATA IS PAIRED-END OR SINGLE-END AND NOT A MIXTURE - if min(numColList) != max(numColList): - print("{}: Mixture of paired-end and single-end reads!".format(ERROR_STR)) - sys.exit(1) - - ## CHECK IF ANTIBODY AND CONTROL COLUMNS HAVE BEEN SPECIFIED AT LEAST ONCE - if len(antibodyDict) == 0: - print("{}: Antibody and Control must be specified at least once!".format(ERROR_STR)) - sys.exit(1) - - ## WRITE READ MAPPING FILE - antibodyGroupDict = {} - fout = open(ReadMappingFile,'w') - fout.write(','.join(['sample_id','fastq_1','fastq_2']) + '\n') - for group in sorted(sampleMappingDict.keys()): - - ## CHECK THAT REPLICATE IDS ARE IN FORMAT 1.. - uniq_rep_ids = set(sampleMappingDict[group].keys()) - if len(uniq_rep_ids) != max(uniq_rep_ids): - print("{}: Replicate IDs must start with 1..\nGroup: {}, Replicate IDs: {}".format(ERROR_STR,group,list(uniq_rep_ids))) - sys.exit(1) - - ## RECONSTRUCT LINE FOR SAMPLE IN DESIGN - for replicate in sorted(sampleMappingDict[group].keys()): - for idx in range(len(sampleMappingDict[group][replicate])): - fastQFiles = sampleMappingDict[group][replicate][idx] - - ## GET SAMPLE_ID,FASTQ_1,FASTQ_2 COLUMNS - sample_id = "{}_R{}_T{}".format(group,replicate,idx+1) - oList = [sample_id] + fastQFiles - if len(fastQFiles) == 1: - oList += [''] - fout.write(','.join(oList) + '\n') - - ## EXTRAPOLATE CONTROL COLUMN - if group in antibodyDict: - antibody,control = antibodyDict[group] - if control in sampleMappingDict.keys(): - control_id = "{}_R1".format(control) - if replicate in sampleMappingDict[control]: - control_id = "{}_R{}".format(control,replicate) - if antibody not in antibodyGroupDict: - antibodyGroupDict[antibody] = {} - if group not in antibodyGroupDict[antibody]: - antibodyGroupDict[antibody][group] = [] - antibodyList = [sample_id[:-3],control_id] - if not antibodyList in antibodyGroupDict[antibody][group]: - antibodyGroupDict[antibody][group].append(antibodyList) - else: - print("{}: Control id not a valid group\nControl id: {}, Valid Groups: {}".format(ERROR_STR,control,sorted(sampleMappingDict.keys()))) - sys.exit(1) - fout.close() - - ## WRITE SAMPLE TO CONTROL MAPPING FILE - fout = open(ControlMappingFile,'w') - fout.write(','.join(['sample_id','control_id','antibody','replicatesExist','multipleGroups']) + '\n') - for antibody in sorted(antibodyGroupDict.keys()): - repsExist = '0' - if max([len(x) for x in antibodyGroupDict[antibody].values()]) > 1: - repsExist = '1' - multipleGroups = '0' - if len(antibodyGroupDict[antibody].keys()) > 1: - multipleGroups = '1' - for group in sorted(antibodyGroupDict[antibody].keys()): - for antibodyList in antibodyGroupDict[antibody][group]: - fout.write(','.join(antibodyList+[antibody,repsExist,multipleGroups]) + '\n') - fout.close() - -############################################ -############################################ -## RUN FUNCTION -############################################ -############################################ - -reformat_design(DesignFile=args.DESIGN_FILE,ReadMappingFile=args.READ_MAPPING_FILE,ControlMappingFile=args.CONTROL_MAPPING_FILE) - -############################################ -############################################ -############################################ -############################################ From 1da324507433a235f93cedc3bd8813e9ad0d432e Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 13 Jul 2020 17:15:23 +0100 Subject: [PATCH 004/538] All uppercase --- conf/base.config | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/conf/base.config b/conf/base.config index f6b9dec38..789af0d6c 100644 --- a/conf/base.config +++ b/conf/base.config @@ -41,7 +41,7 @@ process { withLabel:error_ignore { errorStrategy = 'ignore' } - withName:get_software_versions { + withName:GET_SOFTWARE_VERSIONS { cache = false } From 5b543ca80c20310b1621c06ffa0682d6c965a7d2 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 13 Jul 2020 17:15:33 +0100 Subject: [PATCH 005/538] Strip out boilerplate code --- main.nf | 2975 ++++++++++++++++++++++++------------------------------- 1 file changed, 1311 insertions(+), 1664 deletions(-) diff --git a/main.nf b/main.nf index fa9c455ac..4c63e5497 100755 --- a/main.nf +++ b/main.nf @@ -9,116 +9,25 @@ ---------------------------------------------------------------------------------------- */ -def helpMessage() { - log.info nfcoreHeader() - log.info""" - Usage: +nextflow.preview.dsl = 2 - The typical command for running the pipeline is as follows: - - nextflow run nf-core/chipseq --input design.csv --genome GRCh37 -profile docker - - Mandatory arguments: - --input [file] Comma-separated file containing information about the samples in the experiment (see docs/usage.md) (Default: './design.csv') - --fasta [file] Path to Fasta reference. Not mandatory when using reference in iGenomes config via --genome (Default: false) - --gtf [file] Path to GTF file. Not mandatory when using reference in iGenomes config via --genome (Default: false) - -profile [str] Configuration profile to use. Can use multiple (comma separated) - Available: conda, docker, singularity, awsbatch, test - - Generic - --single_end [bool] Specifies that the input is single-end reads (Default: false) - --seq_center [str] Sequencing center information to be added to read group of BAM files (Default: false) - --fragment_size [int] Estimated fragment size used to extend single-end reads (Default: 200) - --fingerprint_bins [int] Number of genomic bins to use when calculating fingerprint plot (Default: 500000) - - References If not specified in the configuration file or you wish to overwrite any of the references - --genome [str] Name of iGenomes reference (Default: false) - --bwa_index [file] Full path to directory containing BWA index including base name i.e. /path/to/index/genome.fa (Default: false) - --gene_bed [file] Path to BED file containing gene intervals (Default: false) - --macs_gsize [str] Effective genome size parameter required by MACS2. If using iGenomes config, values have only been provided when --genome is set as GRCh37, GRCm38, hg19, mm10, BDGP6 and WBcel235 (Default: false) - --blacklist [file] Path to blacklist regions (.BED format), used for filtering alignments (Default: false) - --save_reference [bool] If generated by the pipeline save the BWA index in the results directory (Default: false) - - Trimming - --clip_r1 [int] Instructs Trim Galore to remove bp from the 5' end of read 1 (or single-end reads) (Default: 0) - --clip_r2 [int] Instructs Trim Galore to remove bp from the 5' end of read 2 (paired-end reads only) (Default: 0) - --three_prime_clip_r1 [int] Instructs Trim Galore to remove bp from the 3' end of read 1 AFTER adapter/quality trimming has been performed (Default: 0) - --three_prime_clip_r2 [int] Instructs Trim Galore to re move bp from the 3' end of read 2 AFTER adapter/quality trimming has been performed (Default: 0) - --trim_nextseq [int] Instructs Trim Galore to apply the --nextseq=X option, to trim based on quality after removing poly-G tails (Default: 0) - --skip_trimming [bool] Skip the adapter trimming step (Default: false) - --save_trimmed [bool] Save the trimmed FastQ files in the results directory (Default: false) - - Alignments - --bwa_min_score [int] Don’t output BWA MEM alignments with score lower than this parameter (Default: false) - --keep_dups [bool] Duplicate reads are not filtered from alignments (Default: false) - --keep_multi_map [bool] Reads mapping to multiple locations are not filtered from alignments (Default: false) - --save_align_intermeds [bool] Save the intermediate BAM files from the alignment step - not done by default (Default: false) - - Peaks - --narrow_peak [bool] Run MACS2 in narrowPeak mode (Default: false) - --broad_cutoff [float] Specifies broad cutoff value for MACS2. Only used when --narrow_peak isnt specified (Default: 0.1) - --macs_fdr [float] Minimum FDR (q-value) cutoff for peak detection, --macs_fdr and --macs_pvalue are mutually exclusive (Default: false) - --macs_pvalue [float] p-value cutoff for peak detection, --macs_fdr and --macs_pvalue are mutually exclusive (Default: false) - --min_reps_consensus [int] Number of biological replicates required from a given condition for a peak to contribute to a consensus peak (Default: 1) - --save_macs_pileup [bool] Instruct MACS2 to create bedGraph files normalised to signal per million reads (Default: false) - --skip_peak_qc [bool] Skip MACS2 peak QC plot generation (Default: false) - --skip_peak_annotation [bool] Skip annotation of MACS2 and consensus peaks with HOMER (Default: false) - --skip_consensus_peaks [bool] Skip consensus peak generation (Default: false) - - Differential analysis - --deseq2_vst [bool] Use vst transformation instead of rlog with DESeq2 (Default: false) - --skip_diff_analysis [bool] Skip differential accessibility analysis (Default: false) - - QC - --skip_fastqc [bool] Skip FastQC (Default: false) - --skip_picard_metrics [bool] Skip Picard CollectMultipleMetrics (Default: false) - --skip_preseq [bool] Skip Preseq (Default: false) - --skip_plot_profile [bool] Skip deepTools plotProfile (Default: false) - --skip_plot_fingerprint [bool] Skip deepTools plotFingerprint (Default: false) - --skip_spp [bool] Skip Phantompeakqualtools (Default: false) - --skip_igv [bool] Skip IGV (Default: false) - --skip_multiqc [bool] Skip MultiQC (Default: false) - - Other - --outdir [file] The output directory where the results will be saved (Default: './results') - --publish_dir_mode [str] Mode for publishing results in the output directory. Available: symlink, rellink, link, copy, copyNoFollow, move (Default: copy) - --email [email] Set this parameter to your e-mail address to get a summary e-mail with details of the run sent to you when the workflow exits (Default: false) - --email_on_fail [email] Same as --email, except only send mail if the workflow is not successful (Default: false) - --max_multiqc_email_size [str] Threshold size for MultiQC report to be attached in notification email. If file generated by pipeline exceeds the threshold, it will not be attached (Default: 25MB) - -name [str] Name for the pipeline run. If not specified, Nextflow will automatically generate a random mnemonic (Default: false) - - AWSBatch options: - --awsqueue [str] The AWSBatch JobQueue that needs to be set when running on AWSBatch - --awsregion [str] The AWS Region for your AWS Batch job to run on - --awscli [str] Path to the AWS CLI tool - """.stripIndent() -} - -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- SET UP CONFIGURATION VARIABLES -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// - -// Show help message +/* + * Print help message if required + */ if (params.help) { - helpMessage() + def command = "nextflow run nf-core/chipseq --input design.csv --genome GRCh37 -profile docker" + log.info Headers.nf_core(workflow, params.monochrome_logs) + log.info Schema.params_help("$baseDir/nextflow_schema.json", command) exit 0 } -// Has the run name been specified by the user? -// this has the bonus effect of catching both -name and --name -custom_runName = params.name -if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { - custom_runName = workflow.runName -} - //////////////////////////////////////////////////// /* -- DEFAULT PARAMETER VALUES -- */ //////////////////////////////////////////////////// +/* + * Reference genomes + */ // Check if genome exists in the config file if (params.genomes && params.genome && !params.genomes.containsKey(params.genome)) { exit 1, "The provided genome '${params.genome}' is not available in the iGenomes file. Currently the available genomes are ${params.genomes.keySet().join(", ")}" @@ -136,37 +45,13 @@ params.anno_readme = params.genome ? params.genomes[ params.genome ].readme ?: f // Global variables def PEAK_TYPE = params.narrow_peak ? 'narrowPeak' : 'broadPeak' -//////////////////////////////////////////////////// -/* -- CONFIG FILES -- */ -//////////////////////////////////////////////////// - -// Pipeline config -ch_multiqc_config = file("$baseDir/assets/multiqc_config.yaml", checkIfExists: true) -ch_multiqc_custom_config = params.multiqc_config ? Channel.fromPath(params.multiqc_config, checkIfExists: true) : Channel.empty() -ch_output_docs = file("$baseDir/docs/output.md", checkIfExists: true) -ch_output_docs_images = file("$baseDir/docs/images/", checkIfExists: true) - -// JSON files required by BAMTools for alignment filtering -if (params.single_end) { - ch_bamtools_filter_config = file(params.bamtools_filter_se_config, checkIfExists: true) -} else { - ch_bamtools_filter_config = file(params.bamtools_filter_pe_config, checkIfExists: true) -} - -// Header files for MultiQC -ch_peak_count_header = file("$baseDir/assets/multiqc/peak_count_header.txt", checkIfExists: true) -ch_frip_score_header = file("$baseDir/assets/multiqc/frip_score_header.txt", checkIfExists: true) -ch_peak_annotation_header = file("$baseDir/assets/multiqc/peak_annotation_header.txt", checkIfExists: true) -ch_deseq2_pca_header = file("$baseDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) -ch_deseq2_clustering_header = file("$baseDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) -ch_spp_correlation_header = file("$baseDir/assets/multiqc/spp_correlation_header.txt", checkIfExists: true) -ch_spp_nsc_header = file("$baseDir/assets/multiqc/spp_nsc_header.txt", checkIfExists: true) -ch_spp_rsc_header = file("$baseDir/assets/multiqc/spp_rsc_header.txt", checkIfExists: true) - //////////////////////////////////////////////////// /* -- VALIDATE INPUTS -- */ //////////////////////////////////////////////////// +/* + * Validate parameters + */ if (params.input) { ch_input = file(params.input, checkIfExists: true) } else { exit 1, 'Samples design file not specified!' } if (params.gtf) { ch_gtf = file(params.gtf, checkIfExists: true) } else { exit 1, 'GTF annotation file not specified!' } if (params.gene_bed) { ch_gene_bed = file(params.gene_bed, checkIfExists: true) } @@ -195,1572 +80,1334 @@ if (params.anno_readme && file(params.anno_readme).exists()) { file(params.anno_readme).copyTo("${params.outdir}/genome/") } -//////////////////////////////////////////////////// -/* -- AWS -- */ -//////////////////////////////////////////////////// - -if (workflow.profile.contains('awsbatch')) { - // AWSBatch sanity checking - if (!params.awsqueue || !params.awsregion) exit 1, 'Specify correct --awsqueue and --awsregion parameters on AWSBatch!' - // Check outdir paths to be S3 buckets if running on AWSBatch - // related: https://github.com/nextflow-io/nextflow/issues/813 - if (!params.outdir.startsWith('s3:')) exit 1, 'Outdir not on S3 - specify S3 Bucket to run on AWSBatch!' - // Prevent trace files to be stored on S3 since S3 does not support rolling files. - if (params.tracedir.startsWith('s3:')) exit 1, 'Specify a local tracedir or run without trace! S3 cannot be used for tracefiles.' -} - -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- HEADER LOG INFO -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// - -// Header log info -log.info nfcoreHeader() -def summary = [:] -summary['Run Name'] = custom_runName ?: workflow.runName -summary['Data Type'] = params.single_end ? 'Single-End' : 'Paired-End' -summary['Design File'] = params.input -summary['Genome'] = params.genome ?: 'Not supplied' -summary['Fasta File'] = params.fasta -summary['GTF File'] = params.gtf -if (params.gene_bed) summary['Gene BED File'] = params.gene_bed -if (params.bwa_index) summary['BWA Index'] = params.bwa_index -if (params.blacklist) summary['Blacklist BED'] = params.blacklist -if (params.bwa_min_score) summary['BWA Min Score'] = params.bwa_min_score -summary['MACS2 Genome Size'] = params.macs_gsize ?: 'Not supplied' -summary['Min Consensus Reps'] = params.min_reps_consensus -if (params.macs_gsize) summary['MACS2 Narrow Peaks'] = params.narrow_peak ? 'Yes' : 'No' -if (!params.narrow_peak) summary['MACS2 Broad Cutoff'] = params.broad_cutoff -if (params.macs_fdr) summary['MACS2 FDR'] = params.macs_fdr -if (params.macs_pvalue) summary['MACS2 P-value'] = params.macs_pvalue -if (params.skip_trimming) { - summary['Trimming Step'] = 'Skipped' -} else { - summary['Trim R1'] = "$params.clip_r1 bp" - summary['Trim R2'] = "$params.clip_r2 bp" - summary["Trim 3' R1"] = "$params.three_prime_clip_r1 bp" - summary["Trim 3' R2"] = "$params.three_prime_clip_r2 bp" - summary['NextSeq Trim'] = "$params.trim_nextseq bp" -} -if (params.seq_center) summary['Sequencing Center'] = params.seq_center -if (params.single_end) summary['Fragment Size'] = "$params.fragment_size bp" -summary['Fingerprint Bins'] = params.fingerprint_bins -if (params.keep_dups) summary['Keep Duplicates'] = 'Yes' -if (params.keep_multi_map) summary['Keep Multi-mapped'] = 'Yes' -summary['Save Genome Index'] = params.save_reference ? 'Yes' : 'No' -if (params.save_trimmed) summary['Save Trimmed'] = 'Yes' -if (params.save_align_intermeds) summary['Save Intermeds'] = 'Yes' -if (params.save_macs_pileup) summary['Save MACS2 Pileup'] = 'Yes' -if (params.skip_peak_qc) summary['Skip MACS2 Peak QC'] = 'Yes' -if (params.skip_peak_annotation) summary['Skip Peak Annotation'] = 'Yes' -if (params.skip_consensus_peaks) summary['Skip Consensus Peaks'] = 'Yes' -if (params.deseq2_vst) summary['Use DESeq2 vst Transform'] = 'Yes' -if (params.skip_diff_analysis) summary['Skip Differential Analysis'] = 'Yes' -if (params.skip_fastqc) summary['Skip FastQC'] = 'Yes' -if (params.skip_picard_metrics) summary['Skip Picard Metrics'] = 'Yes' -if (params.skip_preseq) summary['Skip Preseq'] = 'Yes' -if (params.skip_plot_profile) summary['Skip plotProfile'] = 'Yes' -if (params.skip_plot_fingerprint) summary['Skip plotFingerprint'] = 'Yes' -if (params.skip_spp) summary['Skip spp'] = 'Yes' -if (params.skip_igv) summary['Skip IGV'] = 'Yes' -if (params.skip_multiqc) summary['Skip MultiQC'] = 'Yes' -summary['Max Resources'] = "$params.max_memory memory, $params.max_cpus cpus, $params.max_time time per job" -if (workflow.containerEngine) summary['Container'] = "$workflow.containerEngine - $workflow.container" -summary['Output Dir'] = params.outdir -summary['Launch Dir'] = workflow.launchDir -summary['Working Dir'] = workflow.workDir -summary['Script Dir'] = workflow.projectDir -summary['User'] = workflow.userName -if (workflow.profile.contains('awsbatch')) { - summary['AWS Region'] = params.awsregion - summary['AWS Queue'] = params.awsqueue - summary['AWS CLI'] = params.awscli -} -summary['Config Profile'] = workflow.profile -if (params.config_profile_description) summary['Config Description'] = params.config_profile_description -if (params.config_profile_contact) summary['Config Contact'] = params.config_profile_contact -if (params.config_profile_url) summary['Config URL'] = params.config_profile_url -if (params.email || params.email_on_fail) { - summary['E-mail Address'] = params.email - summary['E-mail on failure'] = params.email_on_fail - summary['MultiQC Max Size'] = params.max_multiqc_email_size -} -log.info summary.collect { k,v -> "${k.padRight(20)}: $v" }.join('\n') -log.info "-\033[2m--------------------------------------------------\033[0m-" - -// Check the hostnames against configured profiles -checkHostname() - -// Show a big warning message if we're not running MACS -if (!params.macs_gsize) { - def warnstring = params.genome ? "supported for '${params.genome}'" : 'supplied' - log.warn "=================================================================\n" + - " WARNING! MACS genome size parameter not $warnstring.\n" + - " Peak calling, annotation and differential analysis will be skipped.\n" + - " Please specify value for '--macs_gsize' to run these steps.\n" + - "=======================================================================" -} - -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- PARSE DESIGN FILE -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// - -/* - * PREPROCESSING: Reformat design file, check validitiy and create IP vs control mappings - */ -process CHECK_DESIGN { - tag "$design" - publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode - - input: - path design from ch_input - - output: - path 'design_reads.csv' into ch_design_reads_csv - path 'design_controls.csv' into ch_design_controls_csv - - script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - """ - check_design.py $design design_reads.csv design_controls.csv - """ -} - -/* - * Create channels for input fastq files - */ -if (params.single_end) { - ch_design_reads_csv - .splitCsv(header:true, sep:',') - .map { row -> [ row.sample_id, [ file(row.fastq_1, checkIfExists: true) ] ] } - .into { ch_raw_reads_fastqc; - ch_raw_reads_trimgalore } -} else { - ch_design_reads_csv - .splitCsv(header:true, sep:',') - .map { row -> [ row.sample_id, [ file(row.fastq_1, checkIfExists: true), file(row.fastq_2, checkIfExists: true) ] ] } - .into { ch_raw_reads_fastqc; - ch_raw_reads_trimgalore } -} - -/* - * Create a channel with [sample_id, control id, antibody, replicatesExist, multipleGroups] - */ -ch_design_controls_csv - .splitCsv(header:true, sep:',') - .map { row -> [ row.sample_id, row.control_id, row.antibody, row.replicatesExist.toBoolean(), row.multipleGroups.toBoolean() ] } - .set { ch_design_controls_csv } - -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- PREPARE ANNOTATION FILES -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// - -/* - * PREPROCESSING: Build BWA index - */ -if (!params.bwa_index) { - process BWA_INDEX { - tag "$fasta" - label 'process_high' - publishDir path: { params.save_reference ? "${params.outdir}/genome" : params.outdir }, - saveAs: { params.save_reference ? it : null }, mode: params.publish_dir_mode - - input: - path fasta from ch_fasta - - output: - path 'BWAIndex' into ch_bwa_index - - script: - """ - bwa index -a bwtsw $fasta - mkdir BWAIndex && mv ${fasta}* BWAIndex - """ - } -} - -/* - * PREPROCESSING: Generate gene BED file - */ -// If --gtf is supplied along with --genome -// Make gene bed from supplied --gtf instead of using iGenomes one automatically -def MAKE_BED = false -if (!params.gene_bed) { - MAKE_BED = true -} else if (params.genome && params.gtf) { - if (params.genomes[ params.genome ].gtf != params.gtf) { - MAKE_BED = true - } -} -if (MAKE_BED) { - process MAKE_GENE_BED { - tag "$gtf" - label 'process_low' - publishDir "${params.outdir}/genome", mode: params.publish_dir_mode - - input: - path gtf from ch_gtf - - output: - path '*.bed' into ch_gene_bed - - script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - """ - gtf2bed $gtf > ${gtf.baseName}.bed - """ - } -} - -/* - * PREPROCESSING: Prepare genome intervals for filtering - */ -process MAKE_GENOME_FILTER { - tag "$fasta" - publishDir "${params.outdir}/genome", mode: params.publish_dir_mode - - input: - path fasta from ch_fasta - path blacklist from ch_blacklist.ifEmpty([]) - - output: - path "$fasta" // FASTA FILE FOR IGV - path '*.fai' // FAI INDEX FOR REFERENCE GENOME - path '*.bed' into ch_genome_filter_regions // BED FILE WITHOUT BLACKLIST REGIONS - path '*.sizes' into ch_genome_sizes_bigwig // CHROMOSOME SIZES FILE FOR BEDTOOLS - - script: - blacklist_filter = params.blacklist ? "sortBed -i $blacklist -g ${fasta}.sizes | complementBed -i stdin -g ${fasta}.sizes" : "awk '{print \$1, '0' , \$2}' OFS='\t' ${fasta}.sizes" - """ - samtools faidx $fasta - cut -f 1,2 ${fasta}.fai > ${fasta}.sizes - $blacklist_filter > ${fasta}.include_regions.bed - """ -} - -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- FASTQ QC -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// - -/* - * STEP 1: FastQC - */ -process FASTQC { - tag "$name" - label 'process_medium' - publishDir "${params.outdir}/fastqc", mode: params.publish_dir_mode, - saveAs: { filename -> - filename.endsWith('.zip') ? "zips/$filename" : filename - } - - when: - !params.skip_fastqc - - input: - tuple val(name), path(reads) from ch_raw_reads_fastqc - - output: - path '*.{zip,html}' into ch_fastqc_reports_mqc - - script: - // Added soft-links to original fastqs for consistent naming in MultiQC - if (params.single_end) { - """ - [ ! -f ${name}.fastq.gz ] && ln -s $reads ${name}.fastq.gz - fastqc -q -t $task.cpus ${name}.fastq.gz - """ - } else { - """ - [ ! -f ${name}_1.fastq.gz ] && ln -s ${reads[0]} ${name}_1.fastq.gz - [ ! -f ${name}_2.fastq.gz ] && ln -s ${reads[1]} ${name}_2.fastq.gz - fastqc -q -t $task.cpus ${name}_1.fastq.gz - fastqc -q -t $task.cpus ${name}_2.fastq.gz - """ - } -} - -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- ADAPTER TRIMMING -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// - -/* - * STEP 2: Trim Galore! - */ -if (params.skip_trimming) { - ch_trimmed_reads = ch_raw_reads_trimgalore - ch_trimgalore_results_mqc = Channel.empty() - ch_trimgalore_fastqc_reports_mqc = Channel.empty() -} else { - process TRIMGALORE { - tag "$name" - label 'process_high' - publishDir "${params.outdir}/trim_galore", mode: params.publish_dir_mode, - saveAs: { filename -> - if (filename.endsWith('.html')) "fastqc/$filename" - else if (filename.endsWith('.zip')) "fastqc/zips/$filename" - else if (filename.endsWith('trimming_report.txt')) "logs/$filename" - else params.save_trimmed ? filename : null - } - - input: - tuple val(name), path(reads) from ch_raw_reads_trimgalore - - output: - tuple val(name), path('*.fq.gz') into ch_trimmed_reads - path '*.txt' into ch_trimgalore_results_mqc - path '*.{zip,html}' into ch_trimgalore_fastqc_reports_mqc - - script: - // Calculate number of --cores for TrimGalore based on value of task.cpus - // See: https://github.com/FelixKrueger/TrimGalore/blob/master/Changelog.md#version-060-release-on-1-mar-2019 - // See: https://github.com/nf-core/atacseq/pull/65 - def cores = 1 - if (task.cpus) { - cores = (task.cpus as int) - 4 - if (params.single_end) cores = (task.cpus as int) - 3 - if (cores < 1) cores = 1 - if (cores > 4) cores = 4 - } - - c_r1 = params.clip_r1 > 0 ? "--clip_r1 ${params.clip_r1}" : '' - c_r2 = params.clip_r2 > 0 ? "--clip_r2 ${params.clip_r2}" : '' - tpc_r1 = params.three_prime_clip_r1 > 0 ? "--three_prime_clip_r1 ${params.three_prime_clip_r1}" : '' - tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' - nextseq = params.trim_nextseq > 0 ? "--nextseq ${params.trim_nextseq}" : '' - - // Added soft-links to original fastqs for consistent naming in MultiQC - if (params.single_end) { - """ - [ ! -f ${name}.fastq.gz ] && ln -s $reads ${name}.fastq.gz - trim_galore --cores $cores --fastqc --gzip $c_r1 $tpc_r1 $nextseq ${name}.fastq.gz - """ - } else { - """ - [ ! -f ${name}_1.fastq.gz ] && ln -s ${reads[0]} ${name}_1.fastq.gz - [ ! -f ${name}_2.fastq.gz ] && ln -s ${reads[1]} ${name}_2.fastq.gz - trim_galore --cores $cores --paired --fastqc --gzip $c_r1 $c_r2 $tpc_r1 $tpc_r2 $nextseq ${name}_1.fastq.gz ${name}_2.fastq.gz - """ - } - } -} - -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- ALIGN -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// - -/* - * STEP 3.1: Map read(s) with bwa mem - */ -process BWA_MEM { - tag "$name" - label 'process_high' - - input: - tuple val(name), path(reads) from ch_trimmed_reads - path index from ch_bwa_index.collect() - - output: - tuple val(name), path('*.bam') into ch_bwa_bam - - script: - prefix = "${name}.Lb" - rg = "\'@RG\\tID:${name}\\tSM:${name.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${name}\\tPU:1\'" - if (params.seq_center) { - rg = "\'@RG\\tID:${name}\\tSM:${name.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${name}\\tPU:1\\tCN:${params.seq_center}\'" - } - score = params.bwa_min_score ? "-T ${params.bwa_min_score}" : '' - """ - bwa mem \\ - -t $task.cpus \\ - -M \\ - -R $rg \\ - $score \\ - ${index}/${bwa_base} \\ - $reads \\ - | samtools view -@ $task.cpus -b -h -F 0x0100 -O BAM -o ${prefix}.bam - - """ -} - -/* - * STEP 3.2: Convert BAM to coordinate sorted BAM - */ -process SORT_BAM { - tag "$name" - label 'process_medium' - if (params.save_align_intermeds) { - publishDir path: "${params.outdir}/bwa/library", mode: params.publish_dir_mode, - saveAs: { filename -> - if (filename.endsWith('.flagstat')) "samtools_stats/$filename" - else if (filename.endsWith('.idxstats')) "samtools_stats/$filename" - else if (filename.endsWith('.stats')) "samtools_stats/$filename" - else filename - } - } - - input: - tuple val(name), path(bam) from ch_bwa_bam - - output: - tuple val(name), path('*.sorted.{bam,bam.bai}') into ch_sort_bam_merge - path '*.{flagstat,idxstats,stats}' into ch_sort_bam_flagstat_mqc - - script: - prefix = "${name}.Lb" - """ - samtools sort -@ $task.cpus -o ${prefix}.sorted.bam -T $name $bam - samtools index ${prefix}.sorted.bam - samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat - samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats - samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats - """ -} - -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- MERGE LIBRARY BAM -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// - /* - * STEP 4.1: Merge BAM files for all libraries from same sample replicate + * Check parameters */ -ch_sort_bam_merge - .map { it -> [ it[0].split('_')[0..-2].join('_'), it[1] ] } - .groupTuple(by: [0]) - .map { it -> [ it[0], it[1].flatten() ] } - .set { ch_sort_bam_merge } +Checks.aws_batch(workflow, params) // Check AWS batch settings +Checks.hostname(workflow, params, log) // Check the hostnames against configured profiles +Checks.macs2_warn(params, log) // Show a big warning message if we're not running MACS -process MERGED_BAM { - tag "$name" - label 'process_medium' - publishDir "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode, - saveAs: { filename -> - if (filename.endsWith('.flagstat')) "samtools_stats/$filename" - else if (filename.endsWith('.idxstats')) "samtools_stats/$filename" - else if (filename.endsWith('.stats')) "samtools_stats/$filename" - else if (filename.endsWith('.metrics.txt')) "picard_metrics/$filename" - else params.save_align_intermeds ? filename : null - } - - input: - tuple val(name), path(bams) from ch_sort_bam_merge - - output: - tuple val(name), path("*${prefix}.sorted.{bam,bam.bai}") into ch_merge_bam_filter, - ch_merge_bam_preseq - path '*.{flagstat,idxstats,stats}' into ch_merge_bam_stats_mqc - path '*.txt' into ch_merge_bam_metrics_mqc - - script: - prefix = "${name}.mLb.mkD" - bam_files = bams.findAll { it.toString().endsWith('.bam') }.sort() - def avail_mem = 3 - if (!task.memory) { - log.info '[Picard MarkDuplicates] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' - } else { - avail_mem = task.memory.toGiga() - } - if (bam_files.size() > 1) { - """ - picard -Xmx${avail_mem}g MergeSamFiles \\ - ${'INPUT='+bam_files.join(' INPUT=')} \\ - OUTPUT=${name}.sorted.bam \\ - SORT_ORDER=coordinate \\ - VALIDATION_STRINGENCY=LENIENT \\ - TMP_DIR=tmp - samtools index ${name}.sorted.bam - - picard -Xmx${avail_mem}g MarkDuplicates \\ - INPUT=${name}.sorted.bam \\ - OUTPUT=${prefix}.sorted.bam \\ - ASSUME_SORTED=true \\ - REMOVE_DUPLICATES=false \\ - METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt \\ - VALIDATION_STRINGENCY=LENIENT \\ - TMP_DIR=tmp - - samtools index ${prefix}.sorted.bam - samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats - samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat - samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats - """ - } else { - """ - picard -Xmx${avail_mem}g MarkDuplicates \\ - INPUT=${bam_files[0]} \\ - OUTPUT=${prefix}.sorted.bam \\ - ASSUME_SORTED=true \\ - REMOVE_DUPLICATES=false \\ - METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt \\ - VALIDATION_STRINGENCY=LENIENT \\ - TMP_DIR=tmp - - samtools index ${prefix}.sorted.bam - samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats - samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat - samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats - """ - } -} +//////////////////////////////////////////////////// +/* -- CONFIG FILES -- */ +//////////////////////////////////////////////////// /* - * STEP 4.2: Filter BAM file at merged library-level + * Stage config files */ -process MERGED_BAM_FILTER { - tag "$name" - label 'process_medium' - publishDir path: "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode, - saveAs: { filename -> - if (params.single_end || params.save_align_intermeds) { - if (filename.endsWith('.flagstat')) "samtools_stats/$filename" - else if (filename.endsWith('.idxstats')) "samtools_stats/$filename" - else if (filename.endsWith('.stats')) "samtools_stats/$filename" - else if (filename.endsWith('.sorted.bam')) filename - else if (filename.endsWith('.sorted.bam.bai')) filename - else null - } - } - - input: - tuple val(name), path(bam) from ch_merge_bam_filter - path bed from ch_genome_filter_regions.collect() - path bamtools_filter_config from ch_bamtools_filter_config - - output: - tuple val(name), path('*.{bam,bam.bai}') into ch_filter_bam - tuple val(name), path('*.flagstat') into ch_filter_bam_flagstat - path '*.{idxstats,stats}' into ch_filter_bam_stats_mqc - - script: - prefix = params.single_end ? "${name}.mLb.clN" : "${name}.mLb.flT" - filter_params = params.single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' - dup_params = params.keep_dups ? '' : '-F 0x0400' - multimap_params = params.keep_multi_map ? '' : '-q 1' - blacklist_params = params.blacklist ? "-L $bed" : '' - name_sort_bam = params.single_end ? '' : "samtools sort -n -@ $task.cpus -o ${prefix}.bam -T $prefix ${prefix}.sorted.bam" - """ - samtools view \\ - $filter_params \\ - $dup_params \\ - $multimap_params \\ - $blacklist_params \\ - -b ${bam[0]} \\ - | bamtools filter \\ - -out ${prefix}.sorted.bam \\ - -script $bamtools_filter_config - - samtools index ${prefix}.sorted.bam - samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat - samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats - samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats - - $name_sort_bam - """ -} +ch_multiqc_config = file("$baseDir/assets/multiqc_config.yaml", checkIfExists: true) +ch_multiqc_custom_config = params.multiqc_config ? Channel.fromPath(params.multiqc_config, checkIfExists: true) : Channel.empty() +ch_output_docs = file("$baseDir/docs/output.md", checkIfExists: true) +ch_output_docs_images = file("$baseDir/docs/images/", checkIfExists: true) -/* - * STEP 4.3: Remove orphan reads from paired-end BAM file - */ +// JSON files required by BAMTools for alignment filtering if (params.single_end) { - ch_filter_bam - .into { ch_rm_orphan_bam_metrics; - ch_rm_orphan_bam_bigwig; - ch_rm_orphan_bam_macs_1; - ch_rm_orphan_bam_macs_2; - ch_rm_orphan_bam_phantompeakqualtools; - ch_rm_orphan_name_bam_counts } - - ch_filter_bam_flagstat - .into { ch_rm_orphan_flagstat_bigwig; - ch_rm_orphan_flagstat_macs; - ch_rm_orphan_flagstat_mqc } - - ch_filter_bam_stats_mqc - .set { ch_rm_orphan_stats_mqc } + ch_bamtools_filter_config = file(params.bamtools_filter_se_config, checkIfExists: true) } else { - process MERGED_BAM_REMOVE_ORPHAN { - tag "$name" - label 'process_medium' - publishDir path: "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode, - saveAs: { filename -> - if (filename.endsWith('.flagstat')) "samtools_stats/$filename" - else if (filename.endsWith('.idxstats')) "samtools_stats/$filename" - else if (filename.endsWith('.stats')) "samtools_stats/$filename" - else if (filename.endsWith('.sorted.bam')) filename - else if (filename.endsWith('.sorted.bam.bai')) filename - else null - } - - input: - tuple val(name), path(bam) from ch_filter_bam - - output: - tuple val(name), path('*.sorted.{bam,bam.bai}') into ch_rm_orphan_bam_metrics, - ch_rm_orphan_bam_bigwig, - ch_rm_orphan_bam_macs_1, - ch_rm_orphan_bam_macs_2, - ch_rm_orphan_bam_phantompeakqualtools - tuple val(name), path("${prefix}.bam") into ch_rm_orphan_name_bam_counts - tuple val(name), path('*.flagstat') into ch_rm_orphan_flagstat_bigwig, - ch_rm_orphan_flagstat_macs, - ch_rm_orphan_flagstat_mqc - path '*.{idxstats,stats}' into ch_rm_orphan_stats_mqc - - script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - prefix = "${name}.mLb.clN" - """ - bampe_rm_orphan.py ${bam[0]} ${prefix}.bam --only_fr_pairs - - samtools sort -@ $task.cpus -o ${prefix}.sorted.bam -T $prefix ${prefix}.bam - samtools index ${prefix}.sorted.bam - samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat - samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats - samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats - """ - } -} - -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- MERGE LIBRARY BAM POST-ANALYSIS -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// - -/* - * STEP 5.1: Preseq analysis after merging libraries and before filtering - */ -process PRESEQ { - tag "$name" - label 'process_medium' - label 'error_ignore' - publishDir "${params.outdir}/bwa/mergedLibrary/preseq", mode: params.publish_dir_mode - - when: - !params.skip_preseq - - input: - tuple val(name), path(bam) from ch_merge_bam_preseq - - output: - path '*.ccurve.txt' into ch_preseq_mqc - path '*.log' - - script: - pe = params.single_end ? '' : '-pe' - """ - preseq lc_extrap \\ - -output ${name}.ccurve.txt \\ - -verbose \\ - -bam \\ - $pe \\ - -seed 1 \\ - ${bam[0]} - cp .command.err ${name}.command.log - """ -} - -/* - * STEP 5.2: Picard CollectMultipleMetrics after merging libraries and filtering - */ -process PICARD_METRICS { - tag "$name" - label 'process_medium' - publishDir path: "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode, - saveAs: { filename -> - if (filename.endsWith('_metrics')) "picard_metrics/$filename" - else if (filename.endsWith('.pdf')) "picard_metrics/pdf/$filename" - else null - } - - when: - !params.skip_picard_metrics - - input: - tuple val(name), path(bam) from ch_rm_orphan_bam_metrics - path fasta from ch_fasta - - output: - path '*_metrics' into ch_collectmetrics_mqc - path '*.pdf' - - script: - prefix = "${name}.mLb.clN" - def avail_mem = 3 - if (!task.memory) { - log.info '[Picard CollectMultipleMetrics] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' - } else { - avail_mem = task.memory.toGiga() - } - """ - picard -Xmx${avail_mem}g CollectMultipleMetrics \\ - INPUT=${bam[0]} \\ - OUTPUT=${prefix}.CollectMultipleMetrics \\ - REFERENCE_SEQUENCE=$fasta \\ - VALIDATION_STRINGENCY=LENIENT \\ - TMP_DIR=tmp - """ -} - -/* - * STEP 5.3: Read depth normalised bigWig - */ -process BIGWIG { - tag "$name" - label 'process_medium' - publishDir "${params.outdir}/bwa/mergedLibrary/bigwig", mode: params.publish_dir_mode, - saveAs: { filename -> - if (filename.endsWith('scale_factor.txt')) "scale/$filename" - else if (filename.endsWith('.bigWig')) filename - else null - } - - input: - tuple val(name), path(bam), path(flagstat) from ch_rm_orphan_bam_bigwig.join(ch_rm_orphan_flagstat_bigwig, by: [0]) - path sizes from ch_genome_sizes_bigwig.collect() - - output: - tuple val(name), path('*.bigWig') into ch_bigwig_plotprofile - path '*igv.txt' into ch_bigwig_igv - path '*scale_factor.txt' - - script: - pe_fragment = params.single_end ? '' : '-pc' - extend = (params.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' - """ - SCALE_FACTOR=\$(grep 'mapped (' $flagstat | awk '{print 1000000/\$1}') - echo \$SCALE_FACTOR > ${name}.scale_factor.txt - genomeCoverageBed -ibam ${bam[0]} -bg -scale \$SCALE_FACTOR $pe_fragment $extend | sort -T '.' -k1,1 -k2,2n > ${name}.bedGraph - - bedGraphToBigWig ${name}.bedGraph $sizes ${name}.bigWig - - find * -type f -name "*.bigWig" -exec echo -e "bwa/mergedLibrary/bigwig/"{}"\\t0,0,178" \\; > ${name}.bigWig.igv.txt - """ -} - -/* - * STEP 5.4: Generate gene body coverage plot with deepTools plotProfile and plotHeatmap - */ -process PLOTPROFILE { - tag "$name" - label 'process_high' - publishDir "${params.outdir}/bwa/mergedLibrary/deepTools/plotProfile", mode: params.publish_dir_mode - - when: - !params.skip_plot_profile - - input: - tuple val(name), path(bigwig) from ch_bigwig_plotprofile - path bed from ch_gene_bed - - output: - path '*.plotProfile.tab' into ch_plotprofile_mqc - path '*.{gz,pdf,mat.tab}' - - script: - """ - computeMatrix scale-regions \\ - --regionsFileName $bed \\ - --scoreFileName $bigwig \\ - --outFileName ${name}.computeMatrix.mat.gz \\ - --outFileNameMatrix ${name}.computeMatrix.vals.mat.tab \\ - --regionBodyLength 1000 \\ - --beforeRegionStartLength 3000 \\ - --afterRegionStartLength 3000 \\ - --skipZeros \\ - --smartLabels \\ - --numberOfProcessors $task.cpus - - plotProfile --matrixFile ${name}.computeMatrix.mat.gz \\ - --outFileName ${name}.plotProfile.pdf \\ - --outFileNameData ${name}.plotProfile.tab - - plotHeatmap --matrixFile ${name}.computeMatrix.mat.gz \\ - --outFileName ${name}.plotHeatmap.pdf \\ - --outFileNameMatrix ${name}.plotHeatmap.mat.tab - """ -} - -/* - * STEP 5.5: Phantompeakqualtools - */ -process PHANTOMPEAKQUALTOOLS { - tag "$name" - label 'process_medium' - publishDir "${params.outdir}/bwa/mergedLibrary/phantompeakqualtools", mode: params.publish_dir_mode - - when: - !params.skip_spp - - input: - tuple val(name), path(bam) from ch_rm_orphan_bam_phantompeakqualtools - path spp_correlation_header from ch_spp_correlation_header - path spp_nsc_header from ch_spp_nsc_header - path spp_rsc_header from ch_spp_rsc_header - - output: - path '*.spp.out' into ch_spp_out_mqc - path '*_mqc.tsv' into ch_spp_csv_mqc - path '*.pdf' - - script: - """ - RUN_SPP=`which run_spp.R` - Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="${bam[0]}" -savp="${name}.spp.pdf" -savd="${name}.spp.Rdata" -out="${name}.spp.out" -p=$task.cpus - cp $spp_correlation_header ${name}_spp_correlation_mqc.tsv - Rscript -e "load('${name}.spp.Rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${name}_spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" - - awk -v OFS='\t' '{print "${name}", \$9}' ${name}.spp.out | cat $spp_nsc_header - > ${name}_spp_nsc_mqc.tsv - awk -v OFS='\t' '{print "${name}", \$10}' ${name}.spp.out | cat $spp_rsc_header - > ${name}_spp_rsc_mqc.tsv - """ -} - -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- MERGE LIBRARY PEAK ANALYSIS -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// - -// Create channel linking IP bams with control bams -ch_rm_orphan_bam_macs_1 - .combine(ch_rm_orphan_bam_macs_2) - .set { ch_rm_orphan_bam_macs_1 } - -ch_design_controls_csv - .combine(ch_rm_orphan_bam_macs_1) - .filter { it[0] == it[5] && it[1] == it[7] } - .join(ch_rm_orphan_flagstat_macs) - .map { it -> it[2..-1] } - .into { ch_group_bam_macs; - ch_group_bam_plotfingerprint; - ch_group_bam_counts } - -/* - * STEP 6.1: deepTools plotFingerprint - */ -process PLOTFINGERPRINT { - tag "${ip} vs ${control}" - label 'process_high' - publishDir "${params.outdir}/bwa/mergedLibrary/deepTools/plotFingerprint", mode: params.publish_dir_mode - - when: - !params.skip_plot_fingerprint - - input: - tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), path(ipbam), val(control), path(controlbam), path(ipflagstat) from ch_group_bam_plotfingerprint - - output: - path '*.raw.txt' into ch_plotfingerprint_mqc - path '*.{txt,pdf}' - - script: - extend = (params.single_end && params.fragment_size > 0) ? "--extendReads ${params.fragment_size}" : '' - """ - plotFingerprint \\ - --bamfiles ${ipbam[0]} ${controlbam[0]} \\ - --plotFile ${ip}.plotFingerprint.pdf \\ - $extend \\ - --labels $ip $control \\ - --outRawCounts ${ip}.plotFingerprint.raw.txt \\ - --outQualityMetrics ${ip}.plotFingerprint.qcmetrics.txt \\ - --skipZeros \\ - --JSDsample ${controlbam[0]} \\ - --numberOfProcessors $task.cpus \\ - --numberOfSamples $params.fingerprint_bins - """ -} - -/* - * STEP 6.2: Call peaks with MACS2 and calculate FRiP score - */ -process MACS2 { - tag "${ip} vs ${control}" - label 'process_medium' - publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (filename.endsWith('.tsv')) "qc/$filename" - else if (filename.endsWith('.igv.txt')) null - else filename - } - - when: - params.macs_gsize - - input: - tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), path(ipbam), val(control), path(controlbam), path(ipflagstat) from ch_group_bam_macs - path peak_count_header from ch_peak_count_header - path frip_score_header from ch_frip_score_header - - output: - tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), val(control), path("*.$PEAK_TYPE") into ch_macs_homer, - ch_macs_qc, - ch_macs_consensus - path '*igv.txt' into ch_macs_igv - path '*_mqc.tsv' into ch_macs_mqc - path '*.{bed,xls,gappedPeak,bdg}' - - script: - broad = params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}" - format = params.single_end ? 'BAM' : 'BAMPE' - pileup = params.save_macs_pileup ? '-B --SPMR' : '' - fdr = params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '' - pvalue = params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' - """ - macs2 callpeak \\ - -t ${ipbam[0]} \\ - -c ${controlbam[0]} \\ - $broad \\ - -f $format \\ - -g $params.macs_gsize \\ - -n $ip \\ - $pileup \\ - $fdr \\ - $pvalue \\ - --keep-dup all - - cat ${ip}_peaks.${PEAK_TYPE} | wc -l | awk -v OFS='\t' '{ print "${ip}", \$1 }' | cat $peak_count_header - > ${ip}_peaks.count_mqc.tsv - - READS_IN_PEAKS=\$(intersectBed -a ${ipbam[0]} -b ${ip}_peaks.${PEAK_TYPE} -bed -c -f 0.20 | awk -F '\t' '{sum += \$NF} END {print sum}') - grep 'mapped (' $ipflagstat | awk -v a="\$READS_IN_PEAKS" -v OFS='\t' '{print "${ip}", a/\$1}' | cat $frip_score_header - > ${ip}_peaks.FRiP_mqc.tsv - - find * -type f -name "*.${PEAK_TYPE}" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/"{}"\\t0,0,178" \\; > ${ip}_peaks.igv.txt - """ -} - -/* - * STEP 6.3: Annotate peaks with HOMER - */ -process MACS2_ANNOTATE { - tag "${ip} vs ${control}" - label 'process_medium' - publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}", mode: params.publish_dir_mode - - when: - params.macs_gsize && !params.skip_peak_annotation - - input: - tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), val(control), path(peak) from ch_macs_homer - path fasta from ch_fasta - path gtf from ch_gtf - - output: - path '*.txt' into ch_macs_annotate - - script: - """ - annotatePeaks.pl \\ - $peak \\ - $fasta \\ - -gid \\ - -gtf $gtf \\ - -cpu $task.cpus \\ - > ${ip}_peaks.annotatePeaks.txt - """ -} - -/* - * STEP 6.4: Aggregated QC plots for peaks, FRiP and peak-to-gene annotation - */ -process MACS2_QC { - label 'process_medium' - publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/qc", mode: params.publish_dir_mode - - when: - params.macs_gsize && !params.skip_peak_annotation && !params.skip_peak_qc - - input: - path peaks from ch_macs_qc.collect{ it[-1] } - path annos from ch_macs_annotate.collect() - path peak_annotation_header from ch_peak_annotation_header - - output: - path '*.tsv' into ch_macs_qc_mqc - path '*.{txt,pdf}' - - script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - """ - plot_macs_qc.r \\ - -i ${peaks.join(',')} \\ - -s ${peaks.join(',').replaceAll("_peaks.${PEAK_TYPE}","")} \\ - -o ./ \\ - -p macs_peak - - plot_homer_annotatepeaks.r \\ - -i ${annos.join(',')} \\ - -s ${annos.join(',').replaceAll("_peaks.annotatePeaks.txt","")} \\ - -o ./ \\ - -p macs_annotatePeaks - - cat $peak_annotation_header macs_annotatePeaks.summary.txt > macs_annotatePeaks.summary_mqc.tsv - """ -} - -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- CONSENSUS PEAKS ANALYSIS -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// - -// Group by ip from this point and carry forward boolean variables -ch_macs_consensus - .map { it -> [ it[0], it[1], it[2], it[-1] ] } - .groupTuple() - .map { it -> [ it[0], it[1][0], it[2][0], it[3].sort() ] } - .set { ch_macs_consensus } - -/* - * STEP 7.1: Consensus peaks across samples, create boolean filtering file, SAF file for featureCounts and UpSetR plot for intersection - */ -process CONSENSUS_PEAKS { - tag "${antibody}" - label 'process_long' - publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (filename.endsWith('.igv.txt')) null - else filename - } - - when: - params.macs_gsize && (replicatesExist || multipleGroups) && !params.skip_consensus_peaks - - input: - tuple val(antibody), val(replicatesExist), val(multipleGroups), path(peaks) from ch_macs_consensus - - output: - tuple val(antibody), val(replicatesExist), val(multipleGroups), path('*.bed') into ch_macs_consensus_bed - tuple val(antibody), path('*.saf') into ch_macs_consensus_saf - path '*.boolean.txt' into ch_macs_consensus_bool - path '*igv.txt' into ch_macs_consensus_igv - path '*.intersect.{txt,plot.pdf}' - - script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ - prefix = "${antibody}.consensus_peaks" - mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') - collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') - expandparam = params.narrow_peak ? '--is_narrow_peak' : '' - """ - sort -T '.' -k1,1 -k2,2n ${peaks.collect{it.toString()}.sort().join(' ')} \\ - | mergeBed -c $mergecols -o $collapsecols > ${prefix}.txt - - macs2_merged_expand.py ${prefix}.txt \\ - ${peaks.collect{it.toString()}.sort().join(',').replaceAll("_peaks.${PEAK_TYPE}","")} \\ - ${prefix}.boolean.txt \\ - --min_replicates $params.min_reps_consensus \\ - $expandparam - - awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$1, \$2, \$3, \$4, "0", "+" }' ${prefix}.boolean.txt > ${prefix}.bed - - echo -e "GeneID\tChr\tStart\tEnd\tStrand" > ${prefix}.saf - awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$4, \$1, \$2, \$3, "+" }' ${prefix}.boolean.txt >> ${prefix}.saf - - plot_peak_intersect.r -i ${prefix}.boolean.intersect.txt -o ${prefix}.boolean.intersect.plot.pdf - - find * -type f -name "${prefix}.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/"{}"\\t0,0,0" \\; > ${prefix}.bed.igv.txt - """ -} - -/* - * STEP 7.2: Annotate consensus peaks with HOMER, and add annotation to boolean output file - */ -process CONSENSUS_PEAKS_ANNOTATE { - tag "${antibody}" - label 'process_medium' - publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}", mode: params.publish_dir_mode - - when: - params.macs_gsize && (replicatesExist || multipleGroups) && !params.skip_consensus_peaks && !params.skip_peak_annotation - - input: - tuple val(antibody), val(replicatesExist), val(multipleGroups), path(bed) from ch_macs_consensus_bed - path bool from ch_macs_consensus_bool - path fasta from ch_fasta - path gtf from ch_gtf - - output: - path '*.annotatePeaks.txt' - - script: - prefix = "${antibody}.consensus_peaks" - """ - annotatePeaks.pl \\ - $bed \\ - $fasta \\ - -gid \\ - -gtf $gtf \\ - -cpu $task.cpus \\ - > ${prefix}.annotatePeaks.txt - - cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt - paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt - """ -} - -// Get BAM and SAF files for each ip -ch_group_bam_counts - .map { it -> [ it[3], [ it[0], it[1], it[2] ] ] } - .join(ch_rm_orphan_name_bam_counts) - .map { it -> [ it[1][0], it[1][1], it[1][2], it[2] ] } - .groupTuple() - .map { it -> [ it[0], it[1][0], it[2][0], it[3].flatten().sort() ] } - .join(ch_macs_consensus_saf) - .set { ch_group_bam_counts } - -/* - * STEP 7.3: Count reads in consensus peaks with featureCounts - */ -process CONSENSUS_PEAKS_COUNTS { - tag "${antibody}" - label 'process_medium' - publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}", mode: params.publish_dir_mode - - when: - params.macs_gsize && (replicatesExist || multipleGroups) && !params.skip_consensus_peaks - - input: - tuple val(antibody), val(replicatesExist), val(multipleGroups), path(bams), path(saf) from ch_group_bam_counts - - output: - tuple val(antibody), val(replicatesExist), val(multipleGroups), path('*featureCounts.txt') into ch_macs_consensus_counts - path '*featureCounts.txt.summary' into ch_macs_consensus_counts_mqc - - script: - prefix = "${antibody}.consensus_peaks" - bam_files = bams.findAll { it.toString().endsWith('.bam') }.sort() - pe_params = params.single_end ? '' : '-p --donotsort' - """ - featureCounts \\ - -F SAF \\ - -O \\ - --fracOverlap 0.2 \\ - -T $task.cpus \\ - $pe_params \\ - -a $saf \\ - -o ${prefix}.featureCounts.txt \\ - ${bam_files.join(' ')} - """ -} - -/* - * STEP 7.4: Differential analysis with DESeq2 - */ -process CONSENSUS_PEAKS_DESEQ2 { - tag "${antibody}" - label 'process_medium' - publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2", mode: params.publish_dir_mode, - saveAs: { filename -> - if (filename.endsWith('.igv.txt')) null - else filename - } - - when: - params.macs_gsize && replicatesExist && multipleGroups && !params.skip_consensus_peaks && !params.skip_diff_analysis - - input: - tuple val(antibody), val(replicatesExist), val(multipleGroups), path(counts) from ch_macs_consensus_counts - path deseq2_pca_header from ch_deseq2_pca_header - path deseq2_clustering_header from ch_deseq2_clustering_header - - output: - path '*.tsv' into ch_macs_consensus_deseq_mqc - path '*igv.txt' into ch_macs_consensus_deseq_comp_igv - path '*.{RData,results.txt,pdf,log}' - path 'sizeFactors' - path '*vs*/*.{pdf,txt}' - path '*vs*/*.bed' - - script: - prefix = "${antibody}.consensus_peaks" - bam_ext = params.single_end ? '.mLb.clN.sorted.bam' : '.mLb.clN.bam' - vst = params.deseq2_vst ? '--vst TRUE' : '' - """ - featurecounts_deseq2.r \\ - --featurecount_file $counts \\ - --bam_suffix '$bam_ext' \\ - --outdir ./ \\ - --outprefix $prefix \\ - --outsuffix '' \\ - --cores $task.cpus \\ - $vst - - sed 's/deseq2_pca/deseq2_pca_${task.index}/g' <$deseq2_pca_header >tmp.txt - sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt - cat tmp.txt ${prefix}.pca.vals.txt > ${prefix}.pca.vals_mqc.tsv - - sed 's/deseq2_clustering/deseq2_clustering_${task.index}/g' <$deseq2_clustering_header >tmp.txt - sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt - cat tmp.txt ${prefix}.sample.dists.txt > ${prefix}.sample.dists_mqc.tsv - - find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt - """ + ch_bamtools_filter_config = file(params.bamtools_filter_pe_config, checkIfExists: true) } -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- IGV -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// - -/* - * STEP 8: Create IGV session file - */ -process IGV { - publishDir "${params.outdir}/igv/${PEAK_TYPE}", mode: params.publish_dir_mode - - when: - !params.skip_igv - - input: - path fasta from ch_fasta - path bigwigs from ch_bigwig_igv.collect().ifEmpty([]) - path peaks from ch_macs_igv.collect().ifEmpty([]) - path consensus_peaks from ch_macs_consensus_igv.collect().ifEmpty([]) - path differential_peaks from ch_macs_consensus_deseq_comp_igv.collect().ifEmpty([]) - - output: - path '*.{txt,xml}' - - script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ - """ - cat *.txt > igv_files.txt - igv_files_to_session.py igv_session.xml igv_files.txt ../../genome/${fasta.getName()} --path_prefix '../../' - """ -} +// Header files for MultiQC +ch_peak_count_header = file("$baseDir/assets/multiqc/peak_count_header.txt", checkIfExists: true) +ch_frip_score_header = file("$baseDir/assets/multiqc/frip_score_header.txt", checkIfExists: true) +ch_peak_annotation_header = file("$baseDir/assets/multiqc/peak_annotation_header.txt", checkIfExists: true) +ch_deseq2_pca_header = file("$baseDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) +ch_deseq2_clustering_header = file("$baseDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) +ch_spp_correlation_header = file("$baseDir/assets/multiqc/spp_correlation_header.txt", checkIfExists: true) +ch_spp_nsc_header = file("$baseDir/assets/multiqc/spp_nsc_header.txt", checkIfExists: true) +ch_spp_rsc_header = file("$baseDir/assets/multiqc/spp_rsc_header.txt", checkIfExists: true) -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- MULTIQC -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// +//////////////////////////////////////////////////// +/* -- PARAMETER SUMMARY -- */ +//////////////////////////////////////////////////// /* - * Parse software version numbers + * Print parameter summary */ -process get_software_versions { - publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode, - saveAs: { filename -> - if (filename.indexOf('.csv') > 0) filename - else null - } - - output: - path 'software_versions_mqc.yaml' into ch_software_versions_mqc - path 'software_versions.csv' - - script: - """ - echo $workflow.manifest.version > v_pipeline.txt - echo $workflow.nextflow.version > v_nextflow.txt - fastqc --version > v_fastqc.txt - trim_galore --version > v_trim_galore.txt - echo \$(bwa 2>&1) > v_bwa.txt - samtools --version > v_samtools.txt - bedtools --version > v_bedtools.txt - echo \$(bamtools --version 2>&1) > v_bamtools.txt - echo \$(plotFingerprint --version 2>&1) > v_deeptools.txt || true - picard MarkDuplicates --version &> v_picard.txt || true - echo \$(R --version 2>&1) > v_R.txt - python -c "import pysam; print(pysam.__version__)" > v_pysam.txt - echo \$(macs2 --version 2>&1) > v_macs2.txt - touch v_homer.txt - echo \$(featureCounts -v 2>&1) > v_featurecounts.txt - preseq &> v_preseq.txt - multiqc --version > v_multiqc.txt - scrape_software_versions.py &> software_versions_mqc.yaml - """ +// Has the run name been specified by the user? +// this has the bonus effect of catching both -name and --name +run_name = params.name +if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { + run_name = workflow.runName } - -Channel.from(summary.collect{ [it.key, it.value] }) - .map { k,v -> "
$k
${v ?: 'N/A'}
" } - .reduce { a, b -> return [a, b].join("\n ") } - .map { x -> """ - id: 'nf-core-chipseq-summary' - description: " - this information is collected when the pipeline is started." - section_name: 'nf-core/chipseq Workflow Summary' - section_href: 'https://github.com/nf-core/chipseq' - plot_type: 'html' - data: | -
- $x -
- """.stripIndent() } - .set { ch_workflow_summary } +summary = Schema.params_summary(workflow, params, run_name) +log.info Headers.nf_core(workflow, params.monochrome_logs) +log.info summary.collect { k,v -> "${k.padRight(22)}: $v" }.join("\n") +log.info "-\033[2m----------------------------------------------------\033[0m-" /* - * STEP 9: MultiQC + * Include local pipeline modules */ -process MULTIQC { - publishDir "${params.outdir}/multiqc/${PEAK_TYPE}", mode: params.publish_dir_mode - - when: - !params.skip_multiqc - - input: - path (multiqc_config) from ch_multiqc_config - path (mqc_custom_config) from ch_multiqc_custom_config.collect().ifEmpty([]) +include { OUTPUT_DOCUMENTATION } from './modules/local/output_documentation' params(params) +include { GET_SOFTWARE_VERSIONS } from './modules/local/get_software_versions' params(params) +include { CHECK_SAMPLESHEET; check_samplesheet_paths } from './modules/local/check_samplesheet' params(params) - path ('software_versions/*') from ch_software_versions_mqc.collect() - path workflow_summary from ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml') - - path ('fastqc/*') from ch_fastqc_reports_mqc.collect().ifEmpty([]) - path ('trimgalore/*') from ch_trimgalore_results_mqc.collect().ifEmpty([]) - path ('trimgalore/fastqc/*') from ch_trimgalore_fastqc_reports_mqc.collect().ifEmpty([]) - - path ('alignment/library/*') from ch_sort_bam_flagstat_mqc.collect() - path ('alignment/mergedLibrary/*') from ch_merge_bam_stats_mqc.collect() - path ('alignment/mergedLibrary/*') from ch_rm_orphan_flagstat_mqc.collect{it[1]} - path ('alignment/mergedLibrary/*') from ch_rm_orphan_stats_mqc.collect() - path ('alignment/mergedLibrary/picard_metrics/*') from ch_merge_bam_metrics_mqc.collect() - path ('alignment/mergedLibrary/picard_metrics/*') from ch_collectmetrics_mqc.collect() - - path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) - path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) - path ('macs/consensus/*') from ch_macs_consensus_counts_mqc.collect().ifEmpty([]) - path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) - - path ('preseq/*') from ch_preseq_mqc.collect().ifEmpty([]) - path ('deeptools/*') from ch_plotfingerprint_mqc.collect().ifEmpty([]) - path ('deeptools/*') from ch_plotprofile_mqc.collect().ifEmpty([]) - path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) - path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) - - output: - path '*multiqc_report.html' into ch_multiqc_report - path '*_data' - - script: - rtitle = custom_runName ? "--title \"$custom_runName\"" : '' - rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' - custom_config_file = params.multiqc_config ? "--config $mqc_custom_config" : '' - """ - multiqc . -f $rtitle $rfilename $custom_config_file - """ -} - -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- REPORTS/DOCUMENTATION -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// +// /* +// * Include nf-core modules +// */ +// include { FASTQC } from './modules/nf-core/fastqc' params(params) +// include { MULTIQC } from './modules/nf-core/multiqc' params(params) /* - * STEP 10: Output description HTML + * Run the workflow */ -process output_documentation { - publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode - - input: - path output_docs from ch_output_docs - path images from ch_output_docs_images - - output: - path 'results_description.html' - - script: - """ - markdown_to_html.py $output_docs -o results_description.html - """ +workflow { + + // CHECK_SAMPLESHEET(ch_input) + // .splitCsv(header:true, sep:',') + // .map { check_samplesheet_paths(it) } + // .set { ch_raw_reads } + // + // FASTQC(ch_raw_reads) + + OUTPUT_DOCUMENTATION( + ch_output_docs, + ch_output_docs_images) + + GET_SOFTWARE_VERSIONS() + + // MULTIQC( + // summary, + // FASTQC.out, + // ch_multiqc_config + // ) } /* - * Completion e-mail notification + * Send completion email */ workflow.onComplete { - - // Set up the e-mail variables - def subject = "[nf-core/chipseq] Successful: $workflow.runName" - if (!workflow.success) { - subject = "[nf-core/chipseq] FAILED: $workflow.runName" - } - def email_fields = [:] - email_fields['version'] = workflow.manifest.version - email_fields['runName'] = custom_runName ?: workflow.runName - email_fields['success'] = workflow.success - email_fields['dateComplete'] = workflow.complete - email_fields['duration'] = workflow.duration - email_fields['exitStatus'] = workflow.exitStatus - email_fields['errorMessage'] = (workflow.errorMessage ?: 'None') - email_fields['errorReport'] = (workflow.errorReport ?: 'None') - email_fields['commandLine'] = workflow.commandLine - email_fields['projectDir'] = workflow.projectDir - email_fields['summary'] = summary - email_fields['summary']['Date Started'] = workflow.start - email_fields['summary']['Date Completed'] = workflow.complete - email_fields['summary']['Pipeline script file path'] = workflow.scriptFile - email_fields['summary']['Pipeline script hash ID'] = workflow.scriptId - if (workflow.repository) email_fields['summary']['Pipeline repository Git URL'] = workflow.repository - if (workflow.commitId) email_fields['summary']['Pipeline repository Git Commit'] = workflow.commitId - if (workflow.revision) email_fields['summary']['Pipeline Git branch/tag'] = workflow.revision - email_fields['summary']['Nextflow Version'] = workflow.nextflow.version - email_fields['summary']['Nextflow Build'] = workflow.nextflow.build - email_fields['summary']['Nextflow Compile Timestamp'] = workflow.nextflow.timestamp - - // On success try attach the multiqc report - def mqc_report = null - try { - if (workflow.success) { - mqc_report = ch_multiqc_report.getVal() - if (mqc_report.getClass() == ArrayList) { - log.warn "[nf-core/chipseq] Found multiple reports from process 'multiqc', will use only one" - mqc_report = mqc_report[0] - } - } - } catch (all) { - log.warn "[nf-core/chipseq] Could not attach MultiQC report to summary email" - } - - // Check if we are only sending emails on failure - email_address = params.email - if (!params.email && params.email_on_fail && !workflow.success) { - email_address = params.email_on_fail - } - - // Render the TXT template - def engine = new groovy.text.GStringTemplateEngine() - def tf = new File("$baseDir/assets/email_template.txt") - def txt_template = engine.createTemplate(tf).make(email_fields) - def email_txt = txt_template.toString() - - // Render the HTML template - def hf = new File("$baseDir/assets/email_template.html") - def html_template = engine.createTemplate(hf).make(email_fields) - def email_html = html_template.toString() - - // Render the sendmail template - def smail_fields = [ email: email_address, subject: subject, email_txt: email_txt, email_html: email_html, baseDir: "$baseDir", mqcFile: mqc_report, mqcMaxSize: params.max_multiqc_email_size.toBytes() ] - def sf = new File("$baseDir/assets/sendmail_template.txt") - def sendmail_template = engine.createTemplate(sf).make(smail_fields) - def sendmail_html = sendmail_template.toString() - - // Send the HTML e-mail - if (email_address) { - try { - if (params.plaintext_email) { throw GroovyException('Send plaintext e-mail, not HTML') } - // Try to send HTML e-mail using sendmail - [ 'sendmail', '-t' ].execute() << sendmail_html - log.info "[nf-core/chipseq] Sent summary e-mail to $email_address (sendmail)" - } catch (all) { - // Catch failures and try with plaintext - [ 'mail', '-s', subject, email_address ].execute() << email_txt - log.info "[nf-core/chipseq] Sent summary e-mail to $email_address (mail)" - } - } - - // Write summary e-mail HTML to a file - def output_d = new File("${params.outdir}/pipeline_info/") - if (!output_d.exists()) { - output_d.mkdirs() - } - def output_hf = new File(output_d, "pipeline_report.html") - output_hf.withWriter { w -> w << email_html } - def output_tf = new File(output_d, "pipeline_report.txt") - output_tf.withWriter { w -> w << email_txt } - - c_green = params.monochrome_logs ? '' : "\033[0;32m"; - c_purple = params.monochrome_logs ? '' : "\033[0;35m"; - c_red = params.monochrome_logs ? '' : "\033[0;31m"; - c_reset = params.monochrome_logs ? '' : "\033[0m"; - - if (workflow.stats.ignoredCount > 0 && workflow.success) { - log.info "-${c_purple}Warning, pipeline completed, but with errored process(es) ${c_reset}-" - log.info "-${c_red}Number of ignored errored process(es) : ${workflow.stats.ignoredCount} ${c_reset}-" - log.info "-${c_green}Number of successfully ran process(es) : ${workflow.stats.succeedCount} ${c_reset}-" - } - - if (workflow.success) { - log.info "-${c_purple}[nf-core/chipseq]${c_green} Pipeline completed successfully${c_reset}-" - } else { - checkHostname() - log.info "-${c_purple}[nf-core/chipseq]${c_red} Pipeline completed with errors${c_reset}-" - } - -} - -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- NF-CORE HEADER -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// - -def nfcoreHeader() { - // Log colors ANSI codes - c_black = params.monochrome_logs ? '' : "\033[0;30m"; - c_blue = params.monochrome_logs ? '' : "\033[0;34m"; - c_cyan = params.monochrome_logs ? '' : "\033[0;36m"; - c_dim = params.monochrome_logs ? '' : "\033[2m"; - c_green = params.monochrome_logs ? '' : "\033[0;32m"; - c_purple = params.monochrome_logs ? '' : "\033[0;35m"; - c_reset = params.monochrome_logs ? '' : "\033[0m"; - c_white = params.monochrome_logs ? '' : "\033[0;37m"; - c_yellow = params.monochrome_logs ? '' : "\033[0;33m"; - - return """ -${c_dim}--------------------------------------------------${c_reset}- - ${c_green},--.${c_black}/${c_green},-.${c_reset} - ${c_blue} ___ __ __ __ ___ ${c_green}/,-._.--~\'${c_reset} - ${c_blue} |\\ | |__ __ / ` / \\ |__) |__ ${c_yellow}} {${c_reset} - ${c_blue} | \\| | \\__, \\__/ | \\ |___ ${c_green}\\`-._,-`-,${c_reset} - ${c_green}`._,._,\'${c_reset} - ${c_purple} nf-core/chipseq v${workflow.manifest.version}${c_reset} - -${c_dim}--------------------------------------------------${c_reset}- - """.stripIndent() -} - -def checkHostname() { - def c_reset = params.monochrome_logs ? '' : "\033[0m" - def c_white = params.monochrome_logs ? '' : "\033[0;37m" - def c_red = params.monochrome_logs ? '' : "\033[1;91m" - def c_yellow_bold = params.monochrome_logs ? '' : "\033[1;93m" - if (params.hostnames) { - def hostname = "hostname".execute().text.trim() - params.hostnames.each { prof, hnames -> - hnames.each { hname -> - if (hostname.contains(hname) && !workflow.profile.contains(prof)) { - log.error "====================================================\n" + - " ${c_red}WARNING!${c_reset} You are running with `-profile $workflow.profile`\n" + - " but your machine hostname is ${c_white}'$hostname'${c_reset}\n" + - " ${c_yellow_bold}It's highly recommended that you use `-profile $prof${c_reset}`\n" + - "============================================================" - } - } - } - } + def multiqc_report = [] + Completion.email(workflow, params, summary, run_name, baseDir, multiqc_report, log) + Completion.summary(workflow, params, log) } +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// /* -- -- */ +// /* -- PARSE DESIGN FILE -- */ +// /* -- -- */ +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// +// /* +// * PREPROCESSING: Reformat design file, check validitiy and create IP vs control mappings +// */ +// process CHECK_DESIGN { +// tag "$design" +// publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode +// +// input: +// path design from ch_input +// +// output: +// path 'design_reads.csv' into ch_design_reads_csv +// path 'design_controls.csv' into ch_design_controls_csv +// +// script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ +// """ +// check_design.py $design design_reads.csv design_controls.csv +// """ +// } +// +// /* +// * Create channels for input fastq files +// */ +// if (params.single_end) { +// ch_design_reads_csv +// .splitCsv(header:true, sep:',') +// .map { row -> [ row.sample_id, [ file(row.fastq_1, checkIfExists: true) ] ] } +// .into { ch_raw_reads_fastqc; +// ch_raw_reads_trimgalore } +// } else { +// ch_design_reads_csv +// .splitCsv(header:true, sep:',') +// .map { row -> [ row.sample_id, [ file(row.fastq_1, checkIfExists: true), file(row.fastq_2, checkIfExists: true) ] ] } +// .into { ch_raw_reads_fastqc; +// ch_raw_reads_trimgalore } +// } +// +// /* +// * Create a channel with [sample_id, control id, antibody, replicatesExist, multipleGroups] +// */ +// ch_design_controls_csv +// .splitCsv(header:true, sep:',') +// .map { row -> [ row.sample_id, row.control_id, row.antibody, row.replicatesExist.toBoolean(), row.multipleGroups.toBoolean() ] } +// .set { ch_design_controls_csv } +// +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// /* -- -- */ +// /* -- PREPARE ANNOTATION FILES -- */ +// /* -- -- */ +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// +// /* +// * PREPROCESSING: Build BWA index +// */ +// if (!params.bwa_index) { +// process BWA_INDEX { +// tag "$fasta" +// label 'process_high' +// publishDir path: { params.save_reference ? "${params.outdir}/genome" : params.outdir }, +// saveAs: { params.save_reference ? it : null }, mode: params.publish_dir_mode +// +// input: +// path fasta from ch_fasta +// +// output: +// path 'BWAIndex' into ch_bwa_index +// +// script: +// """ +// bwa index -a bwtsw $fasta +// mkdir BWAIndex && mv ${fasta}* BWAIndex +// """ +// } +// } +// +// /* +// * PREPROCESSING: Generate gene BED file +// */ +// // If --gtf is supplied along with --genome +// // Make gene bed from supplied --gtf instead of using iGenomes one automatically +// def MAKE_BED = false +// if (!params.gene_bed) { +// MAKE_BED = true +// } else if (params.genome && params.gtf) { +// if (params.genomes[ params.genome ].gtf != params.gtf) { +// MAKE_BED = true +// } +// } +// if (MAKE_BED) { +// process MAKE_GENE_BED { +// tag "$gtf" +// label 'process_low' +// publishDir "${params.outdir}/genome", mode: params.publish_dir_mode +// +// input: +// path gtf from ch_gtf +// +// output: +// path '*.bed' into ch_gene_bed +// +// script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ +// """ +// gtf2bed $gtf > ${gtf.baseName}.bed +// """ +// } +// } +// +// /* +// * PREPROCESSING: Prepare genome intervals for filtering +// */ +// process MAKE_GENOME_FILTER { +// tag "$fasta" +// publishDir "${params.outdir}/genome", mode: params.publish_dir_mode +// +// input: +// path fasta from ch_fasta +// path blacklist from ch_blacklist.ifEmpty([]) +// +// output: +// path "$fasta" // FASTA FILE FOR IGV +// path '*.fai' // FAI INDEX FOR REFERENCE GENOME +// path '*.bed' into ch_genome_filter_regions // BED FILE WITHOUT BLACKLIST REGIONS +// path '*.sizes' into ch_genome_sizes_bigwig // CHROMOSOME SIZES FILE FOR BEDTOOLS +// +// script: +// blacklist_filter = params.blacklist ? "sortBed -i $blacklist -g ${fasta}.sizes | complementBed -i stdin -g ${fasta}.sizes" : "awk '{print \$1, '0' , \$2}' OFS='\t' ${fasta}.sizes" +// """ +// samtools faidx $fasta +// cut -f 1,2 ${fasta}.fai > ${fasta}.sizes +// $blacklist_filter > ${fasta}.include_regions.bed +// """ +// } +// +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// /* -- -- */ +// /* -- FASTQ QC -- */ +// /* -- -- */ +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// +// /* +// * STEP 1: FastQC +// */ +// process FASTQC { +// tag "$name" +// label 'process_medium' +// publishDir "${params.outdir}/fastqc", mode: params.publish_dir_mode, +// saveAs: { filename -> +// filename.endsWith('.zip') ? "zips/$filename" : filename +// } +// +// when: +// !params.skip_fastqc +// +// input: +// tuple val(name), path(reads) from ch_raw_reads_fastqc +// +// output: +// path '*.{zip,html}' into ch_fastqc_reports_mqc +// +// script: +// // Added soft-links to original fastqs for consistent naming in MultiQC +// if (params.single_end) { +// """ +// [ ! -f ${name}.fastq.gz ] && ln -s $reads ${name}.fastq.gz +// fastqc -q -t $task.cpus ${name}.fastq.gz +// """ +// } else { +// """ +// [ ! -f ${name}_1.fastq.gz ] && ln -s ${reads[0]} ${name}_1.fastq.gz +// [ ! -f ${name}_2.fastq.gz ] && ln -s ${reads[1]} ${name}_2.fastq.gz +// fastqc -q -t $task.cpus ${name}_1.fastq.gz +// fastqc -q -t $task.cpus ${name}_2.fastq.gz +// """ +// } +// } +// +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// /* -- -- */ +// /* -- ADAPTER TRIMMING -- */ +// /* -- -- */ +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// +// /* +// * STEP 2: Trim Galore! +// */ +// if (params.skip_trimming) { +// ch_trimmed_reads = ch_raw_reads_trimgalore +// ch_trimgalore_results_mqc = Channel.empty() +// ch_trimgalore_fastqc_reports_mqc = Channel.empty() +// } else { +// process TRIMGALORE { +// tag "$name" +// label 'process_high' +// publishDir "${params.outdir}/trim_galore", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (filename.endsWith('.html')) "fastqc/$filename" +// else if (filename.endsWith('.zip')) "fastqc/zips/$filename" +// else if (filename.endsWith('trimming_report.txt')) "logs/$filename" +// else params.save_trimmed ? filename : null +// } +// +// input: +// tuple val(name), path(reads) from ch_raw_reads_trimgalore +// +// output: +// tuple val(name), path('*.fq.gz') into ch_trimmed_reads +// path '*.txt' into ch_trimgalore_results_mqc +// path '*.{zip,html}' into ch_trimgalore_fastqc_reports_mqc +// +// script: +// // Calculate number of --cores for TrimGalore based on value of task.cpus +// // See: https://github.com/FelixKrueger/TrimGalore/blob/master/Changelog.md#version-060-release-on-1-mar-2019 +// // See: https://github.com/nf-core/atacseq/pull/65 +// def cores = 1 +// if (task.cpus) { +// cores = (task.cpus as int) - 4 +// if (params.single_end) cores = (task.cpus as int) - 3 +// if (cores < 1) cores = 1 +// if (cores > 4) cores = 4 +// } +// +// c_r1 = params.clip_r1 > 0 ? "--clip_r1 ${params.clip_r1}" : '' +// c_r2 = params.clip_r2 > 0 ? "--clip_r2 ${params.clip_r2}" : '' +// tpc_r1 = params.three_prime_clip_r1 > 0 ? "--three_prime_clip_r1 ${params.three_prime_clip_r1}" : '' +// tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' +// nextseq = params.trim_nextseq > 0 ? "--nextseq ${params.trim_nextseq}" : '' +// +// // Added soft-links to original fastqs for consistent naming in MultiQC +// if (params.single_end) { +// """ +// [ ! -f ${name}.fastq.gz ] && ln -s $reads ${name}.fastq.gz +// trim_galore --cores $cores --fastqc --gzip $c_r1 $tpc_r1 $nextseq ${name}.fastq.gz +// """ +// } else { +// """ +// [ ! -f ${name}_1.fastq.gz ] && ln -s ${reads[0]} ${name}_1.fastq.gz +// [ ! -f ${name}_2.fastq.gz ] && ln -s ${reads[1]} ${name}_2.fastq.gz +// trim_galore --cores $cores --paired --fastqc --gzip $c_r1 $c_r2 $tpc_r1 $tpc_r2 $nextseq ${name}_1.fastq.gz ${name}_2.fastq.gz +// """ +// } +// } +// } +// +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// /* -- -- */ +// /* -- ALIGN -- */ +// /* -- -- */ +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// +// /* +// * STEP 3.1: Map read(s) with bwa mem +// */ +// process BWA_MEM { +// tag "$name" +// label 'process_high' +// +// input: +// tuple val(name), path(reads) from ch_trimmed_reads +// path index from ch_bwa_index.collect() +// +// output: +// tuple val(name), path('*.bam') into ch_bwa_bam +// +// script: +// prefix = "${name}.Lb" +// rg = "\'@RG\\tID:${name}\\tSM:${name.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${name}\\tPU:1\'" +// if (params.seq_center) { +// rg = "\'@RG\\tID:${name}\\tSM:${name.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${name}\\tPU:1\\tCN:${params.seq_center}\'" +// } +// score = params.bwa_min_score ? "-T ${params.bwa_min_score}" : '' +// """ +// bwa mem \\ +// -t $task.cpus \\ +// -M \\ +// -R $rg \\ +// $score \\ +// ${index}/${bwa_base} \\ +// $reads \\ +// | samtools view -@ $task.cpus -b -h -F 0x0100 -O BAM -o ${prefix}.bam - +// """ +// } +// +// /* +// * STEP 3.2: Convert BAM to coordinate sorted BAM +// */ +// process SORT_BAM { +// tag "$name" +// label 'process_medium' +// if (params.save_align_intermeds) { +// publishDir path: "${params.outdir}/bwa/library", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (filename.endsWith('.flagstat')) "samtools_stats/$filename" +// else if (filename.endsWith('.idxstats')) "samtools_stats/$filename" +// else if (filename.endsWith('.stats')) "samtools_stats/$filename" +// else filename +// } +// } +// +// input: +// tuple val(name), path(bam) from ch_bwa_bam +// +// output: +// tuple val(name), path('*.sorted.{bam,bam.bai}') into ch_sort_bam_merge +// path '*.{flagstat,idxstats,stats}' into ch_sort_bam_flagstat_mqc +// +// script: +// prefix = "${name}.Lb" +// """ +// samtools sort -@ $task.cpus -o ${prefix}.sorted.bam -T $name $bam +// samtools index ${prefix}.sorted.bam +// samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat +// samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats +// samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats +// """ +// } +// +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// /* -- -- */ +// /* -- MERGE LIBRARY BAM -- */ +// /* -- -- */ +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// +// /* +// * STEP 4.1: Merge BAM files for all libraries from same sample replicate +// */ +// ch_sort_bam_merge +// .map { it -> [ it[0].split('_')[0..-2].join('_'), it[1] ] } +// .groupTuple(by: [0]) +// .map { it -> [ it[0], it[1].flatten() ] } +// .set { ch_sort_bam_merge } +// +// process MERGED_BAM { +// tag "$name" +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (filename.endsWith('.flagstat')) "samtools_stats/$filename" +// else if (filename.endsWith('.idxstats')) "samtools_stats/$filename" +// else if (filename.endsWith('.stats')) "samtools_stats/$filename" +// else if (filename.endsWith('.metrics.txt')) "picard_metrics/$filename" +// else params.save_align_intermeds ? filename : null +// } +// +// input: +// tuple val(name), path(bams) from ch_sort_bam_merge +// +// output: +// tuple val(name), path("*${prefix}.sorted.{bam,bam.bai}") into ch_merge_bam_filter, +// ch_merge_bam_preseq +// path '*.{flagstat,idxstats,stats}' into ch_merge_bam_stats_mqc +// path '*.txt' into ch_merge_bam_metrics_mqc +// +// script: +// prefix = "${name}.mLb.mkD" +// bam_files = bams.findAll { it.toString().endsWith('.bam') }.sort() +// def avail_mem = 3 +// if (!task.memory) { +// log.info '[Picard MarkDuplicates] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' +// } else { +// avail_mem = task.memory.toGiga() +// } +// if (bam_files.size() > 1) { +// """ +// picard -Xmx${avail_mem}g MergeSamFiles \\ +// ${'INPUT='+bam_files.join(' INPUT=')} \\ +// OUTPUT=${name}.sorted.bam \\ +// SORT_ORDER=coordinate \\ +// VALIDATION_STRINGENCY=LENIENT \\ +// TMP_DIR=tmp +// samtools index ${name}.sorted.bam +// +// picard -Xmx${avail_mem}g MarkDuplicates \\ +// INPUT=${name}.sorted.bam \\ +// OUTPUT=${prefix}.sorted.bam \\ +// ASSUME_SORTED=true \\ +// REMOVE_DUPLICATES=false \\ +// METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt \\ +// VALIDATION_STRINGENCY=LENIENT \\ +// TMP_DIR=tmp +// +// samtools index ${prefix}.sorted.bam +// samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats +// samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat +// samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats +// """ +// } else { +// """ +// picard -Xmx${avail_mem}g MarkDuplicates \\ +// INPUT=${bam_files[0]} \\ +// OUTPUT=${prefix}.sorted.bam \\ +// ASSUME_SORTED=true \\ +// REMOVE_DUPLICATES=false \\ +// METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt \\ +// VALIDATION_STRINGENCY=LENIENT \\ +// TMP_DIR=tmp +// +// samtools index ${prefix}.sorted.bam +// samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats +// samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat +// samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats +// """ +// } +// } +// +// /* +// * STEP 4.2: Filter BAM file at merged library-level +// */ +// process MERGED_BAM_FILTER { +// tag "$name" +// label 'process_medium' +// publishDir path: "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (params.single_end || params.save_align_intermeds) { +// if (filename.endsWith('.flagstat')) "samtools_stats/$filename" +// else if (filename.endsWith('.idxstats')) "samtools_stats/$filename" +// else if (filename.endsWith('.stats')) "samtools_stats/$filename" +// else if (filename.endsWith('.sorted.bam')) filename +// else if (filename.endsWith('.sorted.bam.bai')) filename +// else null +// } +// } +// +// input: +// tuple val(name), path(bam) from ch_merge_bam_filter +// path bed from ch_genome_filter_regions.collect() +// path bamtools_filter_config from ch_bamtools_filter_config +// +// output: +// tuple val(name), path('*.{bam,bam.bai}') into ch_filter_bam +// tuple val(name), path('*.flagstat') into ch_filter_bam_flagstat +// path '*.{idxstats,stats}' into ch_filter_bam_stats_mqc +// +// script: +// prefix = params.single_end ? "${name}.mLb.clN" : "${name}.mLb.flT" +// filter_params = params.single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' +// dup_params = params.keep_dups ? '' : '-F 0x0400' +// multimap_params = params.keep_multi_map ? '' : '-q 1' +// blacklist_params = params.blacklist ? "-L $bed" : '' +// name_sort_bam = params.single_end ? '' : "samtools sort -n -@ $task.cpus -o ${prefix}.bam -T $prefix ${prefix}.sorted.bam" +// """ +// samtools view \\ +// $filter_params \\ +// $dup_params \\ +// $multimap_params \\ +// $blacklist_params \\ +// -b ${bam[0]} \\ +// | bamtools filter \\ +// -out ${prefix}.sorted.bam \\ +// -script $bamtools_filter_config +// +// samtools index ${prefix}.sorted.bam +// samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat +// samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats +// samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats +// +// $name_sort_bam +// """ +// } +// +// /* +// * STEP 4.3: Remove orphan reads from paired-end BAM file +// */ +// if (params.single_end) { +// ch_filter_bam +// .into { ch_rm_orphan_bam_metrics; +// ch_rm_orphan_bam_bigwig; +// ch_rm_orphan_bam_macs_1; +// ch_rm_orphan_bam_macs_2; +// ch_rm_orphan_bam_phantompeakqualtools; +// ch_rm_orphan_name_bam_counts } +// +// ch_filter_bam_flagstat +// .into { ch_rm_orphan_flagstat_bigwig; +// ch_rm_orphan_flagstat_macs; +// ch_rm_orphan_flagstat_mqc } +// +// ch_filter_bam_stats_mqc +// .set { ch_rm_orphan_stats_mqc } +// } else { +// process MERGED_BAM_REMOVE_ORPHAN { +// tag "$name" +// label 'process_medium' +// publishDir path: "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (filename.endsWith('.flagstat')) "samtools_stats/$filename" +// else if (filename.endsWith('.idxstats')) "samtools_stats/$filename" +// else if (filename.endsWith('.stats')) "samtools_stats/$filename" +// else if (filename.endsWith('.sorted.bam')) filename +// else if (filename.endsWith('.sorted.bam.bai')) filename +// else null +// } +// +// input: +// tuple val(name), path(bam) from ch_filter_bam +// +// output: +// tuple val(name), path('*.sorted.{bam,bam.bai}') into ch_rm_orphan_bam_metrics, +// ch_rm_orphan_bam_bigwig, +// ch_rm_orphan_bam_macs_1, +// ch_rm_orphan_bam_macs_2, +// ch_rm_orphan_bam_phantompeakqualtools +// tuple val(name), path("${prefix}.bam") into ch_rm_orphan_name_bam_counts +// tuple val(name), path('*.flagstat') into ch_rm_orphan_flagstat_bigwig, +// ch_rm_orphan_flagstat_macs, +// ch_rm_orphan_flagstat_mqc +// path '*.{idxstats,stats}' into ch_rm_orphan_stats_mqc +// +// script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ +// prefix = "${name}.mLb.clN" +// """ +// bampe_rm_orphan.py ${bam[0]} ${prefix}.bam --only_fr_pairs +// +// samtools sort -@ $task.cpus -o ${prefix}.sorted.bam -T $prefix ${prefix}.bam +// samtools index ${prefix}.sorted.bam +// samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat +// samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats +// samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats +// """ +// } +// } +// +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// /* -- -- */ +// /* -- MERGE LIBRARY BAM POST-ANALYSIS -- */ +// /* -- -- */ +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// +// /* +// * STEP 5.1: Preseq analysis after merging libraries and before filtering +// */ +// process PRESEQ { +// tag "$name" +// label 'process_medium' +// label 'error_ignore' +// publishDir "${params.outdir}/bwa/mergedLibrary/preseq", mode: params.publish_dir_mode +// +// when: +// !params.skip_preseq +// +// input: +// tuple val(name), path(bam) from ch_merge_bam_preseq +// +// output: +// path '*.ccurve.txt' into ch_preseq_mqc +// path '*.log' +// +// script: +// pe = params.single_end ? '' : '-pe' +// """ +// preseq lc_extrap \\ +// -output ${name}.ccurve.txt \\ +// -verbose \\ +// -bam \\ +// $pe \\ +// -seed 1 \\ +// ${bam[0]} +// cp .command.err ${name}.command.log +// """ +// } +// +// /* +// * STEP 5.2: Picard CollectMultipleMetrics after merging libraries and filtering +// */ +// process PICARD_METRICS { +// tag "$name" +// label 'process_medium' +// publishDir path: "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (filename.endsWith('_metrics')) "picard_metrics/$filename" +// else if (filename.endsWith('.pdf')) "picard_metrics/pdf/$filename" +// else null +// } +// +// when: +// !params.skip_picard_metrics +// +// input: +// tuple val(name), path(bam) from ch_rm_orphan_bam_metrics +// path fasta from ch_fasta +// +// output: +// path '*_metrics' into ch_collectmetrics_mqc +// path '*.pdf' +// +// script: +// prefix = "${name}.mLb.clN" +// def avail_mem = 3 +// if (!task.memory) { +// log.info '[Picard CollectMultipleMetrics] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' +// } else { +// avail_mem = task.memory.toGiga() +// } +// """ +// picard -Xmx${avail_mem}g CollectMultipleMetrics \\ +// INPUT=${bam[0]} \\ +// OUTPUT=${prefix}.CollectMultipleMetrics \\ +// REFERENCE_SEQUENCE=$fasta \\ +// VALIDATION_STRINGENCY=LENIENT \\ +// TMP_DIR=tmp +// """ +// } +// +// /* +// * STEP 5.3: Read depth normalised bigWig +// */ +// process BIGWIG { +// tag "$name" +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/bigwig", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (filename.endsWith('scale_factor.txt')) "scale/$filename" +// else if (filename.endsWith('.bigWig')) filename +// else null +// } +// +// input: +// tuple val(name), path(bam), path(flagstat) from ch_rm_orphan_bam_bigwig.join(ch_rm_orphan_flagstat_bigwig, by: [0]) +// path sizes from ch_genome_sizes_bigwig.collect() +// +// output: +// tuple val(name), path('*.bigWig') into ch_bigwig_plotprofile +// path '*igv.txt' into ch_bigwig_igv +// path '*scale_factor.txt' +// +// script: +// pe_fragment = params.single_end ? '' : '-pc' +// extend = (params.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' +// """ +// SCALE_FACTOR=\$(grep 'mapped (' $flagstat | awk '{print 1000000/\$1}') +// echo \$SCALE_FACTOR > ${name}.scale_factor.txt +// genomeCoverageBed -ibam ${bam[0]} -bg -scale \$SCALE_FACTOR $pe_fragment $extend | sort -T '.' -k1,1 -k2,2n > ${name}.bedGraph +// +// bedGraphToBigWig ${name}.bedGraph $sizes ${name}.bigWig +// +// find * -type f -name "*.bigWig" -exec echo -e "bwa/mergedLibrary/bigwig/"{}"\\t0,0,178" \\; > ${name}.bigWig.igv.txt +// """ +// } +// +// /* +// * STEP 5.4: Generate gene body coverage plot with deepTools plotProfile and plotHeatmap +// */ +// process PLOTPROFILE { +// tag "$name" +// label 'process_high' +// publishDir "${params.outdir}/bwa/mergedLibrary/deepTools/plotProfile", mode: params.publish_dir_mode +// +// when: +// !params.skip_plot_profile +// +// input: +// tuple val(name), path(bigwig) from ch_bigwig_plotprofile +// path bed from ch_gene_bed +// +// output: +// path '*.plotProfile.tab' into ch_plotprofile_mqc +// path '*.{gz,pdf,mat.tab}' +// +// script: +// """ +// computeMatrix scale-regions \\ +// --regionsFileName $bed \\ +// --scoreFileName $bigwig \\ +// --outFileName ${name}.computeMatrix.mat.gz \\ +// --outFileNameMatrix ${name}.computeMatrix.vals.mat.tab \\ +// --regionBodyLength 1000 \\ +// --beforeRegionStartLength 3000 \\ +// --afterRegionStartLength 3000 \\ +// --skipZeros \\ +// --smartLabels \\ +// --numberOfProcessors $task.cpus +// +// plotProfile --matrixFile ${name}.computeMatrix.mat.gz \\ +// --outFileName ${name}.plotProfile.pdf \\ +// --outFileNameData ${name}.plotProfile.tab +// +// plotHeatmap --matrixFile ${name}.computeMatrix.mat.gz \\ +// --outFileName ${name}.plotHeatmap.pdf \\ +// --outFileNameMatrix ${name}.plotHeatmap.mat.tab +// """ +// } +// +// /* +// * STEP 5.5: Phantompeakqualtools +// */ +// process PHANTOMPEAKQUALTOOLS { +// tag "$name" +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/phantompeakqualtools", mode: params.publish_dir_mode +// +// when: +// !params.skip_spp +// +// input: +// tuple val(name), path(bam) from ch_rm_orphan_bam_phantompeakqualtools +// path spp_correlation_header from ch_spp_correlation_header +// path spp_nsc_header from ch_spp_nsc_header +// path spp_rsc_header from ch_spp_rsc_header +// +// output: +// path '*.spp.out' into ch_spp_out_mqc +// path '*_mqc.tsv' into ch_spp_csv_mqc +// path '*.pdf' +// +// script: +// """ +// RUN_SPP=`which run_spp.R` +// Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="${bam[0]}" -savp="${name}.spp.pdf" -savd="${name}.spp.Rdata" -out="${name}.spp.out" -p=$task.cpus +// cp $spp_correlation_header ${name}_spp_correlation_mqc.tsv +// Rscript -e "load('${name}.spp.Rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${name}_spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" +// +// awk -v OFS='\t' '{print "${name}", \$9}' ${name}.spp.out | cat $spp_nsc_header - > ${name}_spp_nsc_mqc.tsv +// awk -v OFS='\t' '{print "${name}", \$10}' ${name}.spp.out | cat $spp_rsc_header - > ${name}_spp_rsc_mqc.tsv +// """ +// } +// +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// /* -- -- */ +// /* -- MERGE LIBRARY PEAK ANALYSIS -- */ +// /* -- -- */ +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// +// // Create channel linking IP bams with control bams +// ch_rm_orphan_bam_macs_1 +// .combine(ch_rm_orphan_bam_macs_2) +// .set { ch_rm_orphan_bam_macs_1 } +// +// ch_design_controls_csv +// .combine(ch_rm_orphan_bam_macs_1) +// .filter { it[0] == it[5] && it[1] == it[7] } +// .join(ch_rm_orphan_flagstat_macs) +// .map { it -> it[2..-1] } +// .into { ch_group_bam_macs; +// ch_group_bam_plotfingerprint; +// ch_group_bam_counts } +// +// /* +// * STEP 6.1: deepTools plotFingerprint +// */ +// process PLOTFINGERPRINT { +// tag "${ip} vs ${control}" +// label 'process_high' +// publishDir "${params.outdir}/bwa/mergedLibrary/deepTools/plotFingerprint", mode: params.publish_dir_mode +// +// when: +// !params.skip_plot_fingerprint +// +// input: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), path(ipbam), val(control), path(controlbam), path(ipflagstat) from ch_group_bam_plotfingerprint +// +// output: +// path '*.raw.txt' into ch_plotfingerprint_mqc +// path '*.{txt,pdf}' +// +// script: +// extend = (params.single_end && params.fragment_size > 0) ? "--extendReads ${params.fragment_size}" : '' +// """ +// plotFingerprint \\ +// --bamfiles ${ipbam[0]} ${controlbam[0]} \\ +// --plotFile ${ip}.plotFingerprint.pdf \\ +// $extend \\ +// --labels $ip $control \\ +// --outRawCounts ${ip}.plotFingerprint.raw.txt \\ +// --outQualityMetrics ${ip}.plotFingerprint.qcmetrics.txt \\ +// --skipZeros \\ +// --JSDsample ${controlbam[0]} \\ +// --numberOfProcessors $task.cpus \\ +// --numberOfSamples $params.fingerprint_bins +// """ +// } +// +// /* +// * STEP 6.2: Call peaks with MACS2 and calculate FRiP score +// */ +// process MACS2 { +// tag "${ip} vs ${control}" +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (filename.endsWith('.tsv')) "qc/$filename" +// else if (filename.endsWith('.igv.txt')) null +// else filename +// } +// +// when: +// params.macs_gsize +// +// input: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), path(ipbam), val(control), path(controlbam), path(ipflagstat) from ch_group_bam_macs +// path peak_count_header from ch_peak_count_header +// path frip_score_header from ch_frip_score_header +// +// output: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), val(control), path("*.$PEAK_TYPE") into ch_macs_homer, +// ch_macs_qc, +// ch_macs_consensus +// path '*igv.txt' into ch_macs_igv +// path '*_mqc.tsv' into ch_macs_mqc +// path '*.{bed,xls,gappedPeak,bdg}' +// +// script: +// broad = params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}" +// format = params.single_end ? 'BAM' : 'BAMPE' +// pileup = params.save_macs_pileup ? '-B --SPMR' : '' +// fdr = params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '' +// pvalue = params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' +// """ +// macs2 callpeak \\ +// -t ${ipbam[0]} \\ +// -c ${controlbam[0]} \\ +// $broad \\ +// -f $format \\ +// -g $params.macs_gsize \\ +// -n $ip \\ +// $pileup \\ +// $fdr \\ +// $pvalue \\ +// --keep-dup all +// +// cat ${ip}_peaks.${PEAK_TYPE} | wc -l | awk -v OFS='\t' '{ print "${ip}", \$1 }' | cat $peak_count_header - > ${ip}_peaks.count_mqc.tsv +// +// READS_IN_PEAKS=\$(intersectBed -a ${ipbam[0]} -b ${ip}_peaks.${PEAK_TYPE} -bed -c -f 0.20 | awk -F '\t' '{sum += \$NF} END {print sum}') +// grep 'mapped (' $ipflagstat | awk -v a="\$READS_IN_PEAKS" -v OFS='\t' '{print "${ip}", a/\$1}' | cat $frip_score_header - > ${ip}_peaks.FRiP_mqc.tsv +// +// find * -type f -name "*.${PEAK_TYPE}" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/"{}"\\t0,0,178" \\; > ${ip}_peaks.igv.txt +// """ +// } +// +// /* +// * STEP 6.3: Annotate peaks with HOMER +// */ +// process MACS2_ANNOTATE { +// tag "${ip} vs ${control}" +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}", mode: params.publish_dir_mode +// +// when: +// params.macs_gsize && !params.skip_peak_annotation +// +// input: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), val(control), path(peak) from ch_macs_homer +// path fasta from ch_fasta +// path gtf from ch_gtf +// +// output: +// path '*.txt' into ch_macs_annotate +// +// script: +// """ +// annotatePeaks.pl \\ +// $peak \\ +// $fasta \\ +// -gid \\ +// -gtf $gtf \\ +// -cpu $task.cpus \\ +// > ${ip}_peaks.annotatePeaks.txt +// """ +// } +// +// /* +// * STEP 6.4: Aggregated QC plots for peaks, FRiP and peak-to-gene annotation +// */ +// process MACS2_QC { +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/qc", mode: params.publish_dir_mode +// +// when: +// params.macs_gsize && !params.skip_peak_annotation && !params.skip_peak_qc +// +// input: +// path peaks from ch_macs_qc.collect{ it[-1] } +// path annos from ch_macs_annotate.collect() +// path peak_annotation_header from ch_peak_annotation_header +// +// output: +// path '*.tsv' into ch_macs_qc_mqc +// path '*.{txt,pdf}' +// +// script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ +// """ +// plot_macs_qc.r \\ +// -i ${peaks.join(',')} \\ +// -s ${peaks.join(',').replaceAll("_peaks.${PEAK_TYPE}","")} \\ +// -o ./ \\ +// -p macs_peak +// +// plot_homer_annotatepeaks.r \\ +// -i ${annos.join(',')} \\ +// -s ${annos.join(',').replaceAll("_peaks.annotatePeaks.txt","")} \\ +// -o ./ \\ +// -p macs_annotatePeaks +// +// cat $peak_annotation_header macs_annotatePeaks.summary.txt > macs_annotatePeaks.summary_mqc.tsv +// """ +// } +// +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// /* -- -- */ +// /* -- CONSENSUS PEAKS ANALYSIS -- */ +// /* -- -- */ +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// +// // Group by ip from this point and carry forward boolean variables +// ch_macs_consensus +// .map { it -> [ it[0], it[1], it[2], it[-1] ] } +// .groupTuple() +// .map { it -> [ it[0], it[1][0], it[2][0], it[3].sort() ] } +// .set { ch_macs_consensus } +// +// /* +// * STEP 7.1: Consensus peaks across samples, create boolean filtering file, SAF file for featureCounts and UpSetR plot for intersection +// */ +// process CONSENSUS_PEAKS { +// tag "${antibody}" +// label 'process_long' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (filename.endsWith('.igv.txt')) null +// else filename +// } +// +// when: +// params.macs_gsize && (replicatesExist || multipleGroups) && !params.skip_consensus_peaks +// +// input: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(peaks) from ch_macs_consensus +// +// output: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), path('*.bed') into ch_macs_consensus_bed +// tuple val(antibody), path('*.saf') into ch_macs_consensus_saf +// path '*.boolean.txt' into ch_macs_consensus_bool +// path '*igv.txt' into ch_macs_consensus_igv +// path '*.intersect.{txt,plot.pdf}' +// +// script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ +// prefix = "${antibody}.consensus_peaks" +// mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') +// collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') +// expandparam = params.narrow_peak ? '--is_narrow_peak' : '' +// """ +// sort -T '.' -k1,1 -k2,2n ${peaks.collect{it.toString()}.sort().join(' ')} \\ +// | mergeBed -c $mergecols -o $collapsecols > ${prefix}.txt +// +// macs2_merged_expand.py ${prefix}.txt \\ +// ${peaks.collect{it.toString()}.sort().join(',').replaceAll("_peaks.${PEAK_TYPE}","")} \\ +// ${prefix}.boolean.txt \\ +// --min_replicates $params.min_reps_consensus \\ +// $expandparam +// +// awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$1, \$2, \$3, \$4, "0", "+" }' ${prefix}.boolean.txt > ${prefix}.bed +// +// echo -e "GeneID\tChr\tStart\tEnd\tStrand" > ${prefix}.saf +// awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$4, \$1, \$2, \$3, "+" }' ${prefix}.boolean.txt >> ${prefix}.saf +// +// plot_peak_intersect.r -i ${prefix}.boolean.intersect.txt -o ${prefix}.boolean.intersect.plot.pdf +// +// find * -type f -name "${prefix}.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/"{}"\\t0,0,0" \\; > ${prefix}.bed.igv.txt +// """ +// } +// +// /* +// * STEP 7.2: Annotate consensus peaks with HOMER, and add annotation to boolean output file +// */ +// process CONSENSUS_PEAKS_ANNOTATE { +// tag "${antibody}" +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}", mode: params.publish_dir_mode +// +// when: +// params.macs_gsize && (replicatesExist || multipleGroups) && !params.skip_consensus_peaks && !params.skip_peak_annotation +// +// input: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(bed) from ch_macs_consensus_bed +// path bool from ch_macs_consensus_bool +// path fasta from ch_fasta +// path gtf from ch_gtf +// +// output: +// path '*.annotatePeaks.txt' +// +// script: +// prefix = "${antibody}.consensus_peaks" +// """ +// annotatePeaks.pl \\ +// $bed \\ +// $fasta \\ +// -gid \\ +// -gtf $gtf \\ +// -cpu $task.cpus \\ +// > ${prefix}.annotatePeaks.txt +// +// cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt +// paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt +// """ +// } +// +// // Get BAM and SAF files for each ip +// ch_group_bam_counts +// .map { it -> [ it[3], [ it[0], it[1], it[2] ] ] } +// .join(ch_rm_orphan_name_bam_counts) +// .map { it -> [ it[1][0], it[1][1], it[1][2], it[2] ] } +// .groupTuple() +// .map { it -> [ it[0], it[1][0], it[2][0], it[3].flatten().sort() ] } +// .join(ch_macs_consensus_saf) +// .set { ch_group_bam_counts } +// +// /* +// * STEP 7.3: Count reads in consensus peaks with featureCounts +// */ +// process CONSENSUS_PEAKS_COUNTS { +// tag "${antibody}" +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}", mode: params.publish_dir_mode +// +// when: +// params.macs_gsize && (replicatesExist || multipleGroups) && !params.skip_consensus_peaks +// +// input: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(bams), path(saf) from ch_group_bam_counts +// +// output: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), path('*featureCounts.txt') into ch_macs_consensus_counts +// path '*featureCounts.txt.summary' into ch_macs_consensus_counts_mqc +// +// script: +// prefix = "${antibody}.consensus_peaks" +// bam_files = bams.findAll { it.toString().endsWith('.bam') }.sort() +// pe_params = params.single_end ? '' : '-p --donotsort' +// """ +// featureCounts \\ +// -F SAF \\ +// -O \\ +// --fracOverlap 0.2 \\ +// -T $task.cpus \\ +// $pe_params \\ +// -a $saf \\ +// -o ${prefix}.featureCounts.txt \\ +// ${bam_files.join(' ')} +// """ +// } +// +// /* +// * STEP 7.4: Differential analysis with DESeq2 +// */ +// process CONSENSUS_PEAKS_DESEQ2 { +// tag "${antibody}" +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (filename.endsWith('.igv.txt')) null +// else filename +// } +// +// when: +// params.macs_gsize && replicatesExist && multipleGroups && !params.skip_consensus_peaks && !params.skip_diff_analysis +// +// input: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(counts) from ch_macs_consensus_counts +// path deseq2_pca_header from ch_deseq2_pca_header +// path deseq2_clustering_header from ch_deseq2_clustering_header +// +// output: +// path '*.tsv' into ch_macs_consensus_deseq_mqc +// path '*igv.txt' into ch_macs_consensus_deseq_comp_igv +// path '*.{RData,results.txt,pdf,log}' +// path 'sizeFactors' +// path '*vs*/*.{pdf,txt}' +// path '*vs*/*.bed' +// +// script: +// prefix = "${antibody}.consensus_peaks" +// bam_ext = params.single_end ? '.mLb.clN.sorted.bam' : '.mLb.clN.bam' +// vst = params.deseq2_vst ? '--vst TRUE' : '' +// """ +// featurecounts_deseq2.r \\ +// --featurecount_file $counts \\ +// --bam_suffix '$bam_ext' \\ +// --outdir ./ \\ +// --outprefix $prefix \\ +// --outsuffix '' \\ +// --cores $task.cpus \\ +// $vst +// +// sed 's/deseq2_pca/deseq2_pca_${task.index}/g' <$deseq2_pca_header >tmp.txt +// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt +// cat tmp.txt ${prefix}.pca.vals.txt > ${prefix}.pca.vals_mqc.tsv +// +// sed 's/deseq2_clustering/deseq2_clustering_${task.index}/g' <$deseq2_clustering_header >tmp.txt +// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt +// cat tmp.txt ${prefix}.sample.dists.txt > ${prefix}.sample.dists_mqc.tsv +// +// find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt +// """ +// } +// +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// /* -- -- */ +// /* -- IGV -- */ +// /* -- -- */ +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// +// /* +// * STEP 8: Create IGV session file +// */ +// process IGV { +// publishDir "${params.outdir}/igv/${PEAK_TYPE}", mode: params.publish_dir_mode +// +// when: +// !params.skip_igv +// +// input: +// path fasta from ch_fasta +// path bigwigs from ch_bigwig_igv.collect().ifEmpty([]) +// path peaks from ch_macs_igv.collect().ifEmpty([]) +// path consensus_peaks from ch_macs_consensus_igv.collect().ifEmpty([]) +// path differential_peaks from ch_macs_consensus_deseq_comp_igv.collect().ifEmpty([]) +// +// output: +// path '*.{txt,xml}' +// +// script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ +// """ +// cat *.txt > igv_files.txt +// igv_files_to_session.py igv_session.xml igv_files.txt ../../genome/${fasta.getName()} --path_prefix '../../' +// """ +// } +// +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// /* -- -- */ +// /* -- MULTIQC -- */ +// /* -- -- */ +// /////////////////////////////////////////////////////////////////////////////// +// /////////////////////////////////////////////////////////////////////////////// +// +// Channel.from(summary.collect{ [it.key, it.value] }) +// .map { k,v -> "
$k
${v ?: 'N/A'}
" } +// .reduce { a, b -> return [a, b].join("\n ") } +// .map { x -> """ +// id: 'nf-core-chipseq-summary' +// description: " - this information is collected when the pipeline is started." +// section_name: 'nf-core/chipseq Workflow Summary' +// section_href: 'https://github.com/nf-core/chipseq' +// plot_type: 'html' +// data: | +//
+// $x +//
+// """.stripIndent() } +// .set { ch_workflow_summary } +// +// /* +// * STEP 9: MultiQC +// */ +// process MULTIQC { +// publishDir "${params.outdir}/multiqc/${PEAK_TYPE}", mode: params.publish_dir_mode +// +// when: +// !params.skip_multiqc +// +// input: +// path (multiqc_config) from ch_multiqc_config +// path (mqc_custom_config) from ch_multiqc_custom_config.collect().ifEmpty([]) +// +// path ('software_versions/*') from ch_software_versions_mqc.collect() +// path workflow_summary from ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml') +// +// path ('fastqc/*') from ch_fastqc_reports_mqc.collect().ifEmpty([]) +// path ('trimgalore/*') from ch_trimgalore_results_mqc.collect().ifEmpty([]) +// path ('trimgalore/fastqc/*') from ch_trimgalore_fastqc_reports_mqc.collect().ifEmpty([]) +// +// path ('alignment/library/*') from ch_sort_bam_flagstat_mqc.collect() +// path ('alignment/mergedLibrary/*') from ch_merge_bam_stats_mqc.collect() +// path ('alignment/mergedLibrary/*') from ch_rm_orphan_flagstat_mqc.collect{it[1]} +// path ('alignment/mergedLibrary/*') from ch_rm_orphan_stats_mqc.collect() +// path ('alignment/mergedLibrary/picard_metrics/*') from ch_merge_bam_metrics_mqc.collect() +// path ('alignment/mergedLibrary/picard_metrics/*') from ch_collectmetrics_mqc.collect() +// +// path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) +// path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) +// path ('macs/consensus/*') from ch_macs_consensus_counts_mqc.collect().ifEmpty([]) +// path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) +// +// path ('preseq/*') from ch_preseq_mqc.collect().ifEmpty([]) +// path ('deeptools/*') from ch_plotfingerprint_mqc.collect().ifEmpty([]) +// path ('deeptools/*') from ch_plotprofile_mqc.collect().ifEmpty([]) +// path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) +// path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) +// +// output: +// path '*multiqc_report.html' into ch_multiqc_report +// path '*_data' +// +// script: +// rtitle = custom_runName ? "--title \"$custom_runName\"" : '' +// rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' +// custom_config_file = params.multiqc_config ? "--config $mqc_custom_config" : '' +// """ +// multiqc . -f $rtitle $rfilename $custom_config_file +// """ +// } +// /////////////////////////////////////////////////////////////////////////////// /////////////////////////////////////////////////////////////////////////////// /* -- -- */ From ac3f66238235764eecd98a5495d08c9a2f325c5f Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 13 Jul 2020 17:15:56 +0100 Subject: [PATCH 006/538] Add nf-core modules --- modules/nf-core/fastqc.nf | 32 ++++++++++++++++++++++++ modules/nf-core/multiqc.nf | 51 ++++++++++++++++++++++++++++++++++++++ 2 files changed, 83 insertions(+) create mode 100755 modules/nf-core/fastqc.nf create mode 100755 modules/nf-core/multiqc.nf diff --git a/modules/nf-core/fastqc.nf b/modules/nf-core/fastqc.nf new file mode 100755 index 000000000..5129ab488 --- /dev/null +++ b/modules/nf-core/fastqc.nf @@ -0,0 +1,32 @@ +/* + * FastQC + */ +process FASTQC { + tag "$name" + label 'process_medium' + publishDir "${params.outdir}/fastqc", mode: params.publish_dir_mode, + saveAs: { filename -> + filename.indexOf(".zip") > 0 ? "zips/$filename" : "$filename" + } + + input: + tuple val(name), val(single_end), path(reads) + + output: + path "*.{zip,html}" + + script: + // Add soft-links to original FastQs for consistent naming in pipeline + if (single_end) { + """ + [ ! -f ${name}.fastq.gz ] && ln -s $reads ${name}.fastq.gz + fastqc --quiet --threads $task.cpus ${name}.fastq.gz + """ + } else { + """ + [ ! -f ${name}_1.fastq.gz ] && ln -s ${reads[0]} ${name}_1.fastq.gz + [ ! -f ${name}_2.fastq.gz ] && ln -s ${reads[1]} ${name}_2.fastq.gz + fastqc --quiet --threads $task.cpus ${name}_1.fastq.gz ${name}_2.fastq.gz + """ + } +} diff --git a/modules/nf-core/multiqc.nf b/modules/nf-core/multiqc.nf new file mode 100755 index 000000000..5efb77a52 --- /dev/null +++ b/modules/nf-core/multiqc.nf @@ -0,0 +1,51 @@ +// Has the run name been specified by the user? +// this has the bonus effect of catching both -name and --name +custom_runName = params.name +if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { + custom_runName = workflow.runName +} + +// Channel.from(summary.collect{ [it.key, it.value] }) +// .map { k,v -> "
$k
${v ?: 'N/A'}
" } +// .reduce { a, b -> return [a, b].join("\n ") } +// .map { x -> """ +// id: 'nf-core-chipseq-summary' +// description: " - this information is collected when the pipeline is started." +// section_name: 'nf-core/chipseq Workflow Summary' +// section_href: 'https://github.com/nf-core/chipseq' +// plot_type: 'html' +// data: | +//
+// $x +//
+// """.stripIndent() } +// .set { ch_workflow_summary } + +/* + * MultiQC + */ +process MULTIQC { + publishDir "${params.outdir}/multiqc", mode: params.publish_dir_mode + + input: + path (multiqc_config) from ch_multiqc_config + path (mqc_custom_config) from ch_multiqc_custom_config.collect().ifEmpty([]) + // TODO nf-core: Add in log files from your new processes for MultiQC to find! + path ('fastqc/*') from ch_fastqc_results.collect().ifEmpty([]) + path ('software_versions/*') from ch_software_versions_yaml.collect() + path workflow_summary from ch_workflow_summary.collectFile(name: "workflow_summary_mqc.yaml") + + output: + path "*multiqc_report.html" + path "*_data" + path "multiqc_plots" + + script: + rtitle = custom_runName ? "--title \"$custom_runName\"" : '' + rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' + custom_config_file = params.multiqc_config ? "--config $mqc_custom_config" : '' + // TODO nf-core: Specify which MultiQC modules to use with -m for a faster run time + """ + multiqc -f $rtitle $rfilename $custom_config_file . + """ +} From ed7ed293a46a04d222f9a98089dd51f744a01e97 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 13 Jul 2020 17:16:05 +0100 Subject: [PATCH 007/538] Add local modules --- modules/local/check_samplesheet.nf | 35 +++++++++++++++++++++++++ modules/local/get_software_versions.nf | 36 ++++++++++++++++++++++++++ modules/local/output_documentation.nf | 18 +++++++++++++ 3 files changed, 89 insertions(+) create mode 100755 modules/local/check_samplesheet.nf create mode 100755 modules/local/get_software_versions.nf create mode 100755 modules/local/output_documentation.nf diff --git a/modules/local/check_samplesheet.nf b/modules/local/check_samplesheet.nf new file mode 100755 index 000000000..bc74e20cc --- /dev/null +++ b/modules/local/check_samplesheet.nf @@ -0,0 +1,35 @@ +/* + * Reformat design file, check validitiy and create IP vs control mappings + */ +process CHECK_SAMPLESHEET { + tag "$samplesheet" + publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode + + input: + path samplesheet + + output: + path 'design_reads.csv' + path 'design_controls.csv' + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + """ + check_samplesheet.py $design design_reads.csv design_controls.csv + """ +} + +// // Function to get list of [ sample, single_end?, [ fastq_1, fastq_2 ] ] +// def check_samplesheet_paths(LinkedHashMap samplesheet) { +// def sample = samplesheet.sample +// def single_end = samplesheet.single_end.toBoolean() +// def fastq_1 = samplesheet.fastq_1 +// def fastq_2 = samplesheet.fastq_2 +// +// def array = [] +// if (single_end) { +// array = [ sample, single_end, [ file(fastq_1, checkIfExists: true) ] ] +// } else { +// array = [ sample, single_end, [ file(fastq_1, checkIfExists: true), file(fastq_2, checkIfExists: true) ] ] +// } +// return array +// } diff --git a/modules/local/get_software_versions.nf b/modules/local/get_software_versions.nf new file mode 100755 index 000000000..9d19a8758 --- /dev/null +++ b/modules/local/get_software_versions.nf @@ -0,0 +1,36 @@ +/* + * Parse software version numbers + */ +process GET_SOFTWARE_VERSIONS { + publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode, + saveAs: { filename -> + if (filename.indexOf(".csv") > 0) filename + else null + } + + output: + path 'software_versions_mqc.yaml' + path "software_versions.csv" + + script: + """ + echo $workflow.manifest.version > v_pipeline.txt + echo $workflow.nextflow.version > v_nextflow.txt + fastqc --version > v_fastqc.txt + trim_galore --version > v_trim_galore.txt + echo \$(bwa 2>&1) > v_bwa.txt + samtools --version > v_samtools.txt + bedtools --version > v_bedtools.txt + echo \$(bamtools --version 2>&1) > v_bamtools.txt + echo \$(plotFingerprint --version 2>&1) > v_deeptools.txt || true + picard MarkDuplicates --version &> v_picard.txt || true + echo \$(R --version 2>&1) > v_R.txt + python -c "import pysam; print(pysam.__version__)" > v_pysam.txt + echo \$(macs2 --version 2>&1) > v_macs2.txt + touch v_homer.txt + echo \$(featureCounts -v 2>&1) > v_featurecounts.txt + preseq &> v_preseq.txt + multiqc --version > v_multiqc.txt + scrape_software_versions.py &> software_versions_mqc.yaml + """ +} diff --git a/modules/local/output_documentation.nf b/modules/local/output_documentation.nf new file mode 100755 index 000000000..b6d24b0f5 --- /dev/null +++ b/modules/local/output_documentation.nf @@ -0,0 +1,18 @@ +/* + * Output Markdown documentation to HTML + */ +process OUTPUT_DOCUMENTATION { + publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode + + input: + path output_docs + path images + + output: + path "results_description.html" + + script: + """ + markdown_to_html.py $output_docs -o results_description.html + """ +} From 5fd6bfd4162145a61c6916fe1067d2eab5c77509 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 13 Jul 2020 17:16:21 +0100 Subject: [PATCH 008/538] Add Groovy libs --- lib/Checks.groovy | 47 ++++++++++++ lib/Completion.groovy | 118 +++++++++++++++++++++++++++++ lib/Headers.groovy | 39 ++++++++++ lib/Schema.groovy | 169 ++++++++++++++++++++++++++++++++++++++++++ 4 files changed, 373 insertions(+) create mode 100755 lib/Checks.groovy create mode 100755 lib/Completion.groovy create mode 100755 lib/Headers.groovy create mode 100755 lib/Schema.groovy diff --git a/lib/Checks.groovy b/lib/Checks.groovy new file mode 100755 index 000000000..034e9d838 --- /dev/null +++ b/lib/Checks.groovy @@ -0,0 +1,47 @@ +/* + * This file holds several functions used to perform standard checks for the nf-core pipeline template. + */ + +class Checks { + + static void aws_batch(workflow, params) { + if (workflow.profile.contains('awsbatch')) { + assert !params.awsqueue || !params.awsregion : "Specify correct --awsqueue and --awsregion parameters on AWSBatch!" + // Check outdir paths to be S3 buckets if running on AWSBatch + // related: https://github.com/nextflow-io/nextflow/issues/813 + assert !params.outdir.startsWith('s3:') : "Outdir not on S3 - specify S3 Bucket to run on AWSBatch!" + // Prevent trace files to be stored on S3 since S3 does not support rolling files. + assert params.tracedir.startsWith('s3:') : "Specify a local tracedir or run without trace! S3 cannot be used for tracefiles." + } + } + + static void hostname(workflow, params, log) { + Map colors = Headers.log_colours(params.monochrome_logs) + if (params.hostnames) { + def hostname = "hostname".execute().text.trim() + params.hostnames.each { prof, hnames -> + hnames.each { hname -> + if (hostname.contains(hname) && !workflow.profile.contains(prof)) { + log.info "=${colors.yellow}====================================================${colors.reset}=\n" + + "${colors.yellow}WARN: You are running with `-profile $workflow.profile`\n" + + " but your machine hostname is ${colors.white}'$hostname'${colors.reset}.\n" + + " ${colors.yellow_bold}Please use `-profile $prof${colors.reset}`\n" + + "=${colors.yellow}====================================================${colors.reset}=" + } + } + } + } + } + + // Show a big warning message if we're not running MACS + static void macs2_warn(params, log) { + if (!params.macs_gsize) { + def warnstring = params.genome ? "supported for '${params.genome}'" : 'supplied' + log.warn "=================================================================\n" + + " WARNING! MACS genome size parameter not $warnstring.\n" + + " Peak calling, annotation and differential analysis will be skipped.\n" + + " Please specify value for '--macs_gsize' to run these steps.\n" + + "=======================================================================" + } + } +} diff --git a/lib/Completion.groovy b/lib/Completion.groovy new file mode 100755 index 000000000..bcdcdc71a --- /dev/null +++ b/lib/Completion.groovy @@ -0,0 +1,118 @@ +/* + * Functions to be run on completion of pipeline + */ + +class Completion { + static void email(workflow, params, summary, run_name, baseDir, multiqc_report, log) { + + // Set up the e-mail variables + def subject = "[$workflow.manifest.name] Successful: $workflow.runName" + if (!workflow.success) { + subject = "[$workflow.manifest.name] FAILED: $workflow.runName" + } + + def email_fields = [:] + email_fields['version'] = workflow.manifest.version + email_fields['runName'] = run_name ?: workflow.runName + email_fields['success'] = workflow.success + email_fields['dateComplete'] = workflow.complete + email_fields['duration'] = workflow.duration + email_fields['exitStatus'] = workflow.exitStatus + email_fields['errorMessage'] = (workflow.errorMessage ?: 'None') + email_fields['errorReport'] = (workflow.errorReport ?: 'None') + email_fields['commandLine'] = workflow.commandLine + email_fields['projectDir'] = workflow.projectDir + email_fields['summary'] = summary + email_fields['summary']['Date Started'] = workflow.start + email_fields['summary']['Date Completed'] = workflow.complete + email_fields['summary']['Pipeline script file path'] = workflow.scriptFile + email_fields['summary']['Pipeline script hash ID'] = workflow.scriptId + if (workflow.repository) email_fields['summary']['Pipeline repository Git URL'] = workflow.repository + if (workflow.commitId) email_fields['summary']['Pipeline repository Git Commit'] = workflow.commitId + if (workflow.revision) email_fields['summary']['Pipeline Git branch/tag'] = workflow.revision + email_fields['summary']['Nextflow Version'] = workflow.nextflow.version + email_fields['summary']['Nextflow Build'] = workflow.nextflow.build + email_fields['summary']['Nextflow Compile Timestamp'] = workflow.nextflow.timestamp + + // TODO nf-core: If not using MultiQC, strip out this code (including params.max_multiqc_email_size) + // On success try attach the multiqc report + def mqc_report = null + try { + if (workflow.success) { + mqc_report = multiqc_report.getVal() + if (mqc_report.getClass() == ArrayList) { + log.warn "[$workflow.manifest.name] Found multiple reports from process 'MULTIQC', will use only one" + mqc_report = mqc_report[0] + } + } + } catch (all) { + log.warn "[$workflow.manifest.name] Could not attach MultiQC report to summary email" + } + + // Check if we are only sending emails on failure + def email_address = params.email + if (!params.email && params.email_on_fail && !workflow.success) { + email_address = params.email_on_fail + } + + // Render the TXT template + def engine = new groovy.text.GStringTemplateEngine() + def tf = new File("$baseDir/assets/email_template.txt") + def txt_template = engine.createTemplate(tf).make(email_fields) + def email_txt = txt_template.toString() + + // Render the HTML template + def hf = new File("$baseDir/assets/email_template.html") + def html_template = engine.createTemplate(hf).make(email_fields) + def email_html = html_template.toString() + + // Render the sendmail template + def smail_fields = [ email: email_address, subject: subject, email_txt: email_txt, email_html: email_html, baseDir: "$baseDir", mqcFile: mqc_report, mqcMaxSize: params.max_multiqc_email_size.toBytes() ] + def sf = new File("$baseDir/assets/sendmail_template.txt") + def sendmail_template = engine.createTemplate(sf).make(smail_fields) + def sendmail_html = sendmail_template.toString() + + // Send the HTML e-mail + if (email_address) { + try { + if (params.plaintext_email) { throw GroovyException('Send plaintext e-mail, not HTML') } + // Try to send HTML e-mail using sendmail + [ 'sendmail', '-t' ].execute() << sendmail_html + log.info "[$workflow.manifest.name] Sent summary e-mail to $email_address (sendmail)" + } catch (all) { + // Catch failures and try with plaintext + def mail_cmd = [ 'mail', '-s', subject, '--content-type=text/html', email_address ] + if ( mqc_report.size() <= params.max_multiqc_email_size.toBytes() ) { + mail_cmd += [ '-A', mqc_report ] + } + mail_cmd.execute() << email_html + log.info "[$workflow.manifest.name] Sent summary e-mail to $email_address (mail)" + } + } + + // Write summary e-mail HTML to a file + def output_d = new File("${params.outdir}/pipeline_info/") + if (!output_d.exists()) { + output_d.mkdirs() + } + def output_hf = new File(output_d, "pipeline_report.html") + output_hf.withWriter { w -> w << email_html } + def output_tf = new File(output_d, "pipeline_report.txt") + output_tf.withWriter { w -> w << email_txt } + } + + static void summary(workflow, params, log) { + Map colors = Headers.log_colours(params.monochrome_logs) + if (workflow.stats.ignoredCount > 0 && workflow.success) { + log.info "-${colors.purple}Warning, pipeline completed, but with errored process(es) ${colors.reset}-" + log.info "-${colors.red}Number of ignored errored process(es) : ${workflow.stats.ignoredCount} ${colors.reset}-" + log.info "-${colors.green}Number of successfully ran process(es) : ${workflow.stats.succeedCount} ${colors.reset}-" + } + if (workflow.success) { + log.info "-${colors.purple}[$workflow.manifest.name]${colors.green} Pipeline completed successfully${colors.reset}-" + } else { + Checks.hostname() + log.info "-${colors.purple}[$workflow.manifest.name]${colors.red} Pipeline completed with errors${colors.reset}-" + } + } +} diff --git a/lib/Headers.groovy b/lib/Headers.groovy new file mode 100755 index 000000000..8fd9c8c6f --- /dev/null +++ b/lib/Headers.groovy @@ -0,0 +1,39 @@ +/* + * This file holds several functions used to render the nf-core ANSI header. + */ + +class Headers { + + private static Map log_colours(Boolean monochrome_logs) { + Map colorcodes = [:] + colorcodes['reset'] = monochrome_logs ? '' : "\033[0m" + colorcodes['dim'] = monochrome_logs ? '' : "\033[2m" + colorcodes['black'] = monochrome_logs ? '' : "\033[0;30m" + colorcodes['green'] = monochrome_logs ? '' : "\033[0;32m" + colorcodes['yellow'] = monochrome_logs ? '' : "\033[0;33m" + colorcodes['yellow_bold'] = monochrome_logs ? '' : "\033[1;93m" + colorcodes['blue'] = monochrome_logs ? '' : "\033[0;34m" + colorcodes['purple'] = monochrome_logs ? '' : "\033[0;35m" + colorcodes['cyan'] = monochrome_logs ? '' : "\033[0;36m" + colorcodes['white'] = monochrome_logs ? '' : "\033[0;37m" + colorcodes['red'] = monochrome_logs ? '' : "\033[1;91m" + return colorcodes + } + + static String nf_core(workflow, monochrome_logs) { + Map colors = log_colours(monochrome_logs) + String.format( + """\n + -${colors.dim}----------------------------------------------------${colors.reset}- + ${colors.green},--.${colors.black}/${colors.green},-.${colors.reset} + ${colors.blue} ___ __ __ __ ___ ${colors.green}/,-._.--~\'${colors.reset} + ${colors.blue} |\\ | |__ __ / ` / \\ |__) |__ ${colors.yellow}} {${colors.reset} + ${colors.blue} | \\| | \\__, \\__/ | \\ |___ ${colors.green}\\`-._,-`-,${colors.reset} + ${colors.green}`._,._,\'${colors.reset} + ${colors.purple} ${workflow.manifest.name} v${workflow.manifest.version}${colors.reset} + -${colors.dim}----------------------------------------------------${colors.reset}- + """.stripIndent() + ) + } +} + diff --git a/lib/Schema.groovy b/lib/Schema.groovy new file mode 100755 index 000000000..e07e454c3 --- /dev/null +++ b/lib/Schema.groovy @@ -0,0 +1,169 @@ +/* + * This file holds several functions used to perform JSON parameter validation, help and summary rendering for the nf-core pipeline template. + */ + +import groovy.json.JsonSlurper + +class Schema { + /* + * This method tries to read a JSON params file + */ + private static LinkedHashMap params_get(String path) { + def params_map = new LinkedHashMap() + try { + params_map = params_try(path) + } catch (Exception e) { + println "Could not read parameters settings from JSON. $e" + params_map = new LinkedHashMap() + } + return params_map + } + + /* + Method to actually read in JSON file using Groovy. + Group (as Key), values are all parameters + - Parameter1 as Key, Description as Value + - Parameter2 as Key, Description as Value + .... + Group + - + */ + private static LinkedHashMap params_try(String path) throws Exception { + + def json = new File(path).text + def Map json_params = (Map) new JsonSlurper().parseText(json).get('properties') + + /* Tree looks like this in nf-core schema + * properties <- this is what the first get('properties') gets us + group 1 + properties + description + group 2 + properties + description + group 3 + properties + description + */ + def params_map = new LinkedHashMap() + json_params.each { key, val -> + def Map group = json_params."$key".properties // Gets the property object of the group + def sub_params = new LinkedHashMap() + group.each { innerkey, value -> + sub_params.put("$innerkey", [ "$value.type", "$value.description" ]) + } + params_map.put("$key", sub_params) + } + return params_map + } + + private static Integer params_max_chars(params_map) { + Integer max_chars = 0 + for (group in params_map.keySet()) { + def params = params_map.get(group) // This gets the parameters of that particular group + for (par in params.keySet()) { + if (par.size() > max_chars) { + max_chars = par.size() + } + } + } + return max_chars + } + + private static String params_beautify(params_map) { + String output = "" + def max_chars = params_max_chars(params_map) + 1 + for (group in params_map.keySet()) { + output += group + "\n" + def params = params_map.get(group) // This gets the parameters of that particular group + for (par in params.keySet()) { + def type = "[" + params.get(par)[0] + "]" + def description = params.get(par)[1] + output+= " \u001B[1m" + par.padRight(max_chars) + "\u001B[1m" + type.padRight(10) + description + "\n" + } + output += "\n" + } + return output + } + + private static String params_help(path, command) { + String output = "Typical pipeline command:\n\n" + output += " ${command}\n\n" + output += params_beautify(params_get(path)) + } + + private static LinkedHashMap params_summary(workflow, params, run_name) { + def Map summary = [:] + if (workflow.revision) summary['Pipeline Release'] = workflow.revision + summary['Run Name'] = run_name ?: workflow.runName + summary['Data Type'] = params.single_end ? 'Single-End' : 'Paired-End' + summary['Design File'] = params.input + summary['Genome'] = params.genome ?: 'Not supplied' + summary['Fasta File'] = params.fasta + summary['GTF File'] = params.gtf + if (params.gene_bed) summary['Gene BED File'] = params.gene_bed + if (params.bwa_index) summary['BWA Index'] = params.bwa_index + if (params.blacklist) summary['Blacklist BED'] = params.blacklist + if (params.bwa_min_score) summary['BWA Min Score'] = params.bwa_min_score + summary['MACS2 Genome Size'] = params.macs_gsize ?: 'Not supplied' + summary['Min Consensus Reps'] = params.min_reps_consensus + if (params.macs_gsize) summary['MACS2 Narrow Peaks'] = params.narrow_peak ? 'Yes' : 'No' + if (!params.narrow_peak) summary['MACS2 Broad Cutoff'] = params.broad_cutoff + if (params.macs_fdr) summary['MACS2 FDR'] = params.macs_fdr + if (params.macs_pvalue) summary['MACS2 P-value'] = params.macs_pvalue + if (params.skip_trimming) { + summary['Trimming Step'] = 'Skipped' + } else { + summary['Trim R1'] = "$params.clip_r1 bp" + summary['Trim R2'] = "$params.clip_r2 bp" + summary["Trim 3' R1"] = "$params.three_prime_clip_r1 bp" + summary["Trim 3' R2"] = "$params.three_prime_clip_r2 bp" + summary['NextSeq Trim'] = "$params.trim_nextseq bp" + } + if (params.seq_center) summary['Sequencing Center'] = params.seq_center + if (params.single_end) summary['Fragment Size'] = "$params.fragment_size bp" + summary['Fingerprint Bins'] = params.fingerprint_bins + if (params.keep_dups) summary['Keep Duplicates'] = 'Yes' + if (params.keep_multi_map) summary['Keep Multi-mapped'] = 'Yes' + summary['Save Genome Index'] = params.save_reference ? 'Yes' : 'No' + if (params.save_trimmed) summary['Save Trimmed'] = 'Yes' + if (params.save_align_intermeds) summary['Save Intermeds'] = 'Yes' + if (params.save_macs_pileup) summary['Save MACS2 Pileup'] = 'Yes' + if (params.skip_peak_qc) summary['Skip MACS2 Peak QC'] = 'Yes' + if (params.skip_peak_annotation) summary['Skip Peak Annotation'] = 'Yes' + if (params.skip_consensus_peaks) summary['Skip Consensus Peaks'] = 'Yes' + if (params.deseq2_vst) summary['Use DESeq2 vst Transform'] = 'Yes' + if (params.skip_diff_analysis) summary['Skip Differential Analysis'] = 'Yes' + if (params.skip_fastqc) summary['Skip FastQC'] = 'Yes' + if (params.skip_picard_metrics) summary['Skip Picard Metrics'] = 'Yes' + if (params.skip_preseq) summary['Skip Preseq'] = 'Yes' + if (params.skip_plot_profile) summary['Skip plotProfile'] = 'Yes' + if (params.skip_plot_fingerprint) summary['Skip plotFingerprint'] = 'Yes' + if (params.skip_spp) summary['Skip spp'] = 'Yes' + if (params.skip_igv) summary['Skip IGV'] = 'Yes' + if (params.skip_multiqc) summary['Skip MultiQC'] = 'Yes' + summary['Max Resources'] = "$params.max_memory memory, $params.max_cpus cpus, $params.max_time time per job" + if (workflow.containerEngine) summary['Container'] = "$workflow.containerEngine - $workflow.container" + summary['Output dir'] = params.outdir + summary['Launch dir'] = workflow.launchDir + summary['Working dir'] = workflow.workDir + summary['Script dir'] = workflow.projectDir + summary['User'] = workflow.userName + if (workflow.profile.contains('awsbatch')) { + summary['AWS Region'] = params.awsregion + summary['AWS Queue'] = params.awsqueue + summary['AWS CLI'] = params.awscli + } + summary['Config Profile'] = workflow.profile + if (params.config_profile_description) summary['Config Profile Descr'] = params.config_profile_description + if (params.config_profile_contact) summary['Config Profile Contact'] = params.config_profile_contact + if (params.config_profile_url) summary['Config Profile URL'] = params.config_profile_url + summary['Config Files'] = workflow.configFiles.join(', ') + if (params.email || params.email_on_fail) { + summary['E-mail Address'] = params.email + summary['E-mail on failure'] = params.email_on_fail + summary['MultiQC maxsize'] = params.max_multiqc_email_size + } + return summary + } +} From a039c0e87614cdeba5225207caaa39e6a7d6d837 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 13 Jul 2020 17:21:26 +0100 Subject: [PATCH 009/538] Minor updates --- main.nf | 5 +---- 1 file changed, 1 insertion(+), 4 deletions(-) diff --git a/main.nf b/main.nf index 4c63e5497..632c3038e 100755 --- a/main.nf +++ b/main.nf @@ -189,9 +189,6 @@ workflow.onComplete { // /////////////////////////////////////////////////////////////////////////////// // /////////////////////////////////////////////////////////////////////////////// // -// /* -// * PREPROCESSING: Reformat design file, check validitiy and create IP vs control mappings -// */ // process CHECK_DESIGN { // tag "$design" // publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode @@ -208,7 +205,7 @@ workflow.onComplete { // check_design.py $design design_reads.csv design_controls.csv // """ // } -// + // /* // * Create channels for input fastq files // */ From 9d62b01a2c22c53fb6e60e3b6bc55fcd10db1e30 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 13 Jul 2020 17:26:52 +0100 Subject: [PATCH 010/538] Get tests passing --- modules/local/check_samplesheet.nf | 30 +++++++++++++++--------------- 1 file changed, 15 insertions(+), 15 deletions(-) diff --git a/modules/local/check_samplesheet.nf b/modules/local/check_samplesheet.nf index bc74e20cc..a839758f4 100755 --- a/modules/local/check_samplesheet.nf +++ b/modules/local/check_samplesheet.nf @@ -18,18 +18,18 @@ process CHECK_SAMPLESHEET { """ } -// // Function to get list of [ sample, single_end?, [ fastq_1, fastq_2 ] ] -// def check_samplesheet_paths(LinkedHashMap samplesheet) { -// def sample = samplesheet.sample -// def single_end = samplesheet.single_end.toBoolean() -// def fastq_1 = samplesheet.fastq_1 -// def fastq_2 = samplesheet.fastq_2 -// -// def array = [] -// if (single_end) { -// array = [ sample, single_end, [ file(fastq_1, checkIfExists: true) ] ] -// } else { -// array = [ sample, single_end, [ file(fastq_1, checkIfExists: true), file(fastq_2, checkIfExists: true) ] ] -// } -// return array -// } +// Function to get list of [ sample, single_end?, [ fastq_1, fastq_2 ] ] +def check_samplesheet_paths(LinkedHashMap samplesheet) { + def sample = samplesheet.sample + def single_end = samplesheet.single_end.toBoolean() + def fastq_1 = samplesheet.fastq_1 + def fastq_2 = samplesheet.fastq_2 + + def array = [] + if (single_end) { + array = [ sample, single_end, [ file(fastq_1, checkIfExists: true) ] ] + } else { + array = [ sample, single_end, [ file(fastq_1, checkIfExists: true), file(fastq_2, checkIfExists: true) ] ] + } + return array +} From 76212dc837cd123cd2f5eb4f5cecd92f00d3045c Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 13 Jul 2020 17:48:23 +0100 Subject: [PATCH 011/538] Bump Nextflow version --- .github/workflows/ci.yml | 4 ++-- CHANGELOG.md | 5 +++++ README.md | 2 +- nextflow.config | 2 +- 4 files changed, 9 insertions(+), 4 deletions(-) diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 5cfe6711b..aaed40ac2 100755 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -21,7 +21,7 @@ jobs: strategy: matrix: # Nextflow versions: check pipeline minimum and current latest - nxf_ver: ['19.10.0', ''] + nxf_ver: ['20.04.1', ''] steps: - name: Check out pipeline code uses: actions/checkout@v2 @@ -57,7 +57,7 @@ jobs: if: ${{ github.event_name != 'push' || (github.event_name == 'push' && github.repository == 'nf-core/chipseq') }} runs-on: ubuntu-latest env: - NXF_VER: '19.10.0' + NXF_VER: '20.04.1' NXF_ANSI_LOG: false strategy: matrix: diff --git a/CHANGELOG.md b/CHANGELOG.md index c33552316..4d3d088e8 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -7,10 +7,15 @@ and this project adheres to [Semantic Versioning](http://semver.org/spec/v2.0.0. ### `Added` +* Move template boilerplate code to Groovy `lib/` +* Implement pipeline in DSL 2 + ### `Fixed` ### `Dependencies` +* Update Nextflow `19.10.0` -> `20.04.1` + ## [1.2.0] - 2020-07-02 ### `Added` diff --git a/README.md b/README.md index 09d9d5b47..58ab48a8b 100644 --- a/README.md +++ b/README.md @@ -2,7 +2,7 @@ [![GitHub Actions CI Status](https://github.com/nf-core/chipseq/workflows/nf-core%20CI/badge.svg)](https://github.com/nf-core/chipseq/actions) [![GitHub Actions Linting Status](https://github.com/nf-core/chipseq/workflows/nf-core%20linting/badge.svg)](https://github.com/nf-core/chipseq/actions) -[![Nextflow](https://img.shields.io/badge/nextflow-%E2%89%A519.10.0-brightgreen.svg)](https://www.nextflow.io/) +[![Nextflow](https://img.shields.io/badge/nextflow-%E2%89%A520.04.1-brightgreen.svg)](https://www.nextflow.io/) [![DOI](https://zenodo.org/badge/DOI/10.5281/zenodo.3240506.svg)](https://doi.org/10.5281/zenodo.3240506) [![install with bioconda](https://img.shields.io/badge/install%20with-bioconda-brightgreen.svg)](http://bioconda.github.io/) diff --git a/nextflow.config b/nextflow.config index 2a22eb383..23d6bc75c 100644 --- a/nextflow.config +++ b/nextflow.config @@ -168,7 +168,7 @@ manifest { homePage = 'https://github.com/nf-core/chipseq' description = 'ChIP-seq peak-calling and differential analysis pipeline.' mainScript = 'main.nf' - nextflowVersion = '>=19.10.0' + nextflowVersion = '>=20.04.1' version = '1.3.0dev' } From 4402ada977234b00c37ae297456d52101060362f Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 14 Jul 2020 08:47:50 +0100 Subject: [PATCH 012/538] Update params to hostnames --- lib/Completion.groovy | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/lib/Completion.groovy b/lib/Completion.groovy index bcdcdc71a..4363275dd 100755 --- a/lib/Completion.groovy +++ b/lib/Completion.groovy @@ -111,7 +111,7 @@ class Completion { if (workflow.success) { log.info "-${colors.purple}[$workflow.manifest.name]${colors.green} Pipeline completed successfully${colors.reset}-" } else { - Checks.hostname() + Checks.hostname(workflow, params, log) log.info "-${colors.purple}[$workflow.manifest.name]${colors.red} Pipeline completed with errors${colors.reset}-" } } From 8b4aa8561ab2210ee74cf82ec74f8d79628d35ba Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 14 Jul 2020 08:48:02 +0100 Subject: [PATCH 013/538] Get inputs into pipeline --- main.nf | 78 ++++++++++++++++----------------------------------------- 1 file changed, 21 insertions(+), 57 deletions(-) diff --git a/main.nf b/main.nf index 632c3038e..836632d53 100755 --- a/main.nf +++ b/main.nf @@ -139,7 +139,9 @@ log.info "-\033[2m----------------------------------------------------\033[0m-" */ include { OUTPUT_DOCUMENTATION } from './modules/local/output_documentation' params(params) include { GET_SOFTWARE_VERSIONS } from './modules/local/get_software_versions' params(params) -include { CHECK_SAMPLESHEET; check_samplesheet_paths } from './modules/local/check_samplesheet' params(params) +include { CHECK_SAMPLESHEET + get_samplesheet_paths + get_samplesheet_design } from './modules/local/check_samplesheet' params(params) // /* // * Include nf-core modules @@ -152,12 +154,24 @@ include { CHECK_SAMPLESHEET; check_samplesheet_paths } from './modules/local/che */ workflow { - // CHECK_SAMPLESHEET(ch_input) - // .splitCsv(header:true, sep:',') - // .map { check_samplesheet_paths(it) } - // .set { ch_raw_reads } - // - // FASTQC(ch_raw_reads) + // Get paths to FastQ files + // [sample, single_end?, [ fastq_1, fastq_2 ]] + CHECK_SAMPLESHEET(ch_input) + .reads + .splitCsv(header:true, sep:',') + .map { get_samplesheet_paths(it, params.single_end) } + .set { ch_raw_reads } + + // Get design information from samplesheet + // [sample, control, antibody, replicatesExist?, multipleGroups?] + CHECK_SAMPLESHEET + .out + .controls + .splitCsv(header:true, sep:',') + .map { get_samplesheet_design(it) } + .set { ch_design } + + // FASTQC(ch_raw_reads_fastqc) OUTPUT_DOCUMENTATION( ch_output_docs, @@ -181,56 +195,6 @@ workflow.onComplete { Completion.summary(workflow, params, log) } -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// /* -- -- */ -// /* -- PARSE DESIGN FILE -- */ -// /* -- -- */ -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// -// process CHECK_DESIGN { -// tag "$design" -// publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode -// -// input: -// path design from ch_input -// -// output: -// path 'design_reads.csv' into ch_design_reads_csv -// path 'design_controls.csv' into ch_design_controls_csv -// -// script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ -// """ -// check_design.py $design design_reads.csv design_controls.csv -// """ -// } - -// /* -// * Create channels for input fastq files -// */ -// if (params.single_end) { -// ch_design_reads_csv -// .splitCsv(header:true, sep:',') -// .map { row -> [ row.sample_id, [ file(row.fastq_1, checkIfExists: true) ] ] } -// .into { ch_raw_reads_fastqc; -// ch_raw_reads_trimgalore } -// } else { -// ch_design_reads_csv -// .splitCsv(header:true, sep:',') -// .map { row -> [ row.sample_id, [ file(row.fastq_1, checkIfExists: true), file(row.fastq_2, checkIfExists: true) ] ] } -// .into { ch_raw_reads_fastqc; -// ch_raw_reads_trimgalore } -// } -// -// /* -// * Create a channel with [sample_id, control id, antibody, replicatesExist, multipleGroups] -// */ -// ch_design_controls_csv -// .splitCsv(header:true, sep:',') -// .map { row -> [ row.sample_id, row.control_id, row.antibody, row.replicatesExist.toBoolean(), row.multipleGroups.toBoolean() ] } -// .set { ch_design_controls_csv } -// // /////////////////////////////////////////////////////////////////////////////// // /////////////////////////////////////////////////////////////////////////////// // /* -- -- */ From dab4f8eab19b16c1348e4ad8d2d89d6c8bd32bad Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 14 Jul 2020 08:48:14 +0100 Subject: [PATCH 014/538] Fix Groovy functions --- modules/local/check_samplesheet.nf | 20 ++++++++++++-------- 1 file changed, 12 insertions(+), 8 deletions(-) diff --git a/modules/local/check_samplesheet.nf b/modules/local/check_samplesheet.nf index a839758f4..a8c011a8c 100755 --- a/modules/local/check_samplesheet.nf +++ b/modules/local/check_samplesheet.nf @@ -9,21 +9,20 @@ process CHECK_SAMPLESHEET { path samplesheet output: - path 'design_reads.csv' - path 'design_controls.csv' + path 'samplesheet_reads.csv', emit: reads + path 'samplesheet_controls.csv', emit: controls script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ """ - check_samplesheet.py $design design_reads.csv design_controls.csv + check_samplesheet.py $samplesheet samplesheet_reads.csv samplesheet_controls.csv """ } // Function to get list of [ sample, single_end?, [ fastq_1, fastq_2 ] ] -def check_samplesheet_paths(LinkedHashMap samplesheet) { - def sample = samplesheet.sample - def single_end = samplesheet.single_end.toBoolean() - def fastq_1 = samplesheet.fastq_1 - def fastq_2 = samplesheet.fastq_2 +def get_samplesheet_paths(LinkedHashMap row, boolean single_end) { + def sample = row.sample_id + def fastq_1 = row.fastq_1 + def fastq_2 = row.fastq_2 def array = [] if (single_end) { @@ -33,3 +32,8 @@ def check_samplesheet_paths(LinkedHashMap samplesheet) { } return array } + +// Function to get list of [sample, control, antibody, replicatesExist?, multipleGroups?] +def get_samplesheet_design(LinkedHashMap row) { + return [ row.sample_id, row.control_id, row.antibody, row.replicatesExist.toBoolean(), row.multipleGroups.toBoolean() ] +} From a0dcd6481a8e99433bc76547d4948aa9afc319a2 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 14 Jul 2020 18:47:27 +0100 Subject: [PATCH 015/538] Get processes working until sorting bams --- main.nf | 355 ++++++++++---------------------------------------------- 1 file changed, 62 insertions(+), 293 deletions(-) diff --git a/main.nf b/main.nf index 836632d53..2ccfeea21 100755 --- a/main.nf +++ b/main.nf @@ -59,7 +59,7 @@ if (params.blacklist) { ch_blacklist = Channel.fromPath(params.blacklist, checkI if (params.fasta) { lastPath = params.fasta.lastIndexOf(File.separator) - bwa_base = params.fasta.substring(lastPath+1) + params.bwa_base = params.fasta.substring(lastPath+1) ch_fasta = file(params.fasta, checkIfExists: true) } else { exit 1, 'Fasta file not specified!' @@ -68,7 +68,7 @@ if (params.fasta) { if (params.bwa_index) { lastPath = params.bwa_index.lastIndexOf(File.separator) bwa_dir = params.bwa_index.substring(0,lastPath+1) - bwa_base = params.bwa_index.substring(lastPath+1) + params.bwa_base = params.bwa_index.substring(lastPath+1) Channel .fromPath(bwa_dir, checkIfExists: true) .set { ch_bwa_index } @@ -80,6 +80,17 @@ if (params.anno_readme && file(params.anno_readme).exists()) { file(params.anno_readme).copyTo("${params.outdir}/genome/") } +// If --gtf is supplied along with --genome +// Make gene bed from supplied --gtf instead of using iGenomes one automatically +def MAKE_BED = false +if (!params.gene_bed) { + MAKE_BED = true +} else if (params.genome && params.gtf) { + if (params.genomes[ params.genome ].gtf != params.gtf) { + MAKE_BED = true + } +} + /* * Check parameters */ @@ -137,33 +148,41 @@ log.info "-\033[2m----------------------------------------------------\033[0m-" /* * Include local pipeline modules */ -include { OUTPUT_DOCUMENTATION } from './modules/local/output_documentation' params(params) -include { GET_SOFTWARE_VERSIONS } from './modules/local/get_software_versions' params(params) include { CHECK_SAMPLESHEET get_samplesheet_paths get_samplesheet_design } from './modules/local/check_samplesheet' params(params) +include { GTF2BED } from './modules/local/gtf2bed' params(params) +include { GET_CHROM_SIZES } from './modules/local/get_chrom_sizes' params(params) +include { MAKE_GENOME_FILTER } from './modules/local/make_genome_filter' params(params) +include { OUTPUT_DOCUMENTATION } from './modules/local/output_documentation' params(params) +include { GET_SOFTWARE_VERSIONS } from './modules/local/get_software_versions' params(params) -// /* -// * Include nf-core modules -// */ -// include { FASTQC } from './modules/nf-core/fastqc' params(params) -// include { MULTIQC } from './modules/nf-core/multiqc' params(params) +/* + * Include nf-core modules + */ +include { FASTQC } from './modules/nf-core/fastqc' params(params) +include { BWA_INDEX } from './modules/nf-core/bwa_index' params(params) +include { TRIMGALORE } from './modules/nf-core/trimgalore' params(params) +include { BWA_MEM } from './modules/nf-core/bwa_mem' params(params) +include { SAMTOOLS_SORT } from './modules/nf-core/samtools_sort' params(params) +include { SAMTOOLS_INDEX } from './modules/nf-core/samtools_index' params(params) +include { SAMTOOLS_STATS } from './modules/nf-core/samtools_stats' params(params) +include { MULTIQC } from './modules/nf-core/multiqc' params(params) /* * Run the workflow */ workflow { - // Get paths to FastQ files - // [sample, single_end?, [ fastq_1, fastq_2 ]] + /* + * READ IN SAMPLESHEET + */ CHECK_SAMPLESHEET(ch_input) .reads .splitCsv(header:true, sep:',') .map { get_samplesheet_paths(it, params.single_end) } .set { ch_raw_reads } - // Get design information from samplesheet - // [sample, control, antibody, replicatesExist?, multipleGroups?] CHECK_SAMPLESHEET .out .controls @@ -171,8 +190,37 @@ workflow { .map { get_samplesheet_design(it) } .set { ch_design } - // FASTQC(ch_raw_reads_fastqc) + /* + * PREPARE GENOME FILES + */ + if (!params.bwa_index) { BWA_INDEX(ch_fasta).set { ch_bwa_index } } + if (MAKE_BED) { GTF2BED(ch_gtf).set { ch_gene_bed } } + MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta).sizes, ch_blacklist.ifEmpty([])) + /* + * READ QC & TRIMMING + */ + FASTQC(ch_raw_reads) + if (params.skip_trimming) { + ch_trimmed_reads = ch_raw_reads + ch_trimgalore_log_mqc = Channel.empty() + ch_trimgalore_fastqc_mqc = Channel.empty() + } else { + TRIMGALORE(ch_raw_reads).reads.set { ch_trimmed_reads } + ch_trimgalore_log_mqc = TRIMGALORE.out.log + ch_trimgalore_fastqc_mqc = TRIMGALORE.out.fastqc + } + + /* + * MAP READS & BAM QC + */ + BWA_MEM(ch_trimmed_reads, ch_bwa_index.collect()) + SAMTOOLS_SORT(BWA_MEM.out) | SAMTOOLS_INDEX + SAMTOOLS_STATS(SAMTOOLS_SORT.out) + + /* + * PIPELINE REPORTING + */ OUTPUT_DOCUMENTATION( ch_output_docs, ch_output_docs_images) @@ -195,285 +243,6 @@ workflow.onComplete { Completion.summary(workflow, params, log) } -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// /* -- -- */ -// /* -- PREPARE ANNOTATION FILES -- */ -// /* -- -- */ -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// -// /* -// * PREPROCESSING: Build BWA index -// */ -// if (!params.bwa_index) { -// process BWA_INDEX { -// tag "$fasta" -// label 'process_high' -// publishDir path: { params.save_reference ? "${params.outdir}/genome" : params.outdir }, -// saveAs: { params.save_reference ? it : null }, mode: params.publish_dir_mode -// -// input: -// path fasta from ch_fasta -// -// output: -// path 'BWAIndex' into ch_bwa_index -// -// script: -// """ -// bwa index -a bwtsw $fasta -// mkdir BWAIndex && mv ${fasta}* BWAIndex -// """ -// } -// } -// -// /* -// * PREPROCESSING: Generate gene BED file -// */ -// // If --gtf is supplied along with --genome -// // Make gene bed from supplied --gtf instead of using iGenomes one automatically -// def MAKE_BED = false -// if (!params.gene_bed) { -// MAKE_BED = true -// } else if (params.genome && params.gtf) { -// if (params.genomes[ params.genome ].gtf != params.gtf) { -// MAKE_BED = true -// } -// } -// if (MAKE_BED) { -// process MAKE_GENE_BED { -// tag "$gtf" -// label 'process_low' -// publishDir "${params.outdir}/genome", mode: params.publish_dir_mode -// -// input: -// path gtf from ch_gtf -// -// output: -// path '*.bed' into ch_gene_bed -// -// script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ -// """ -// gtf2bed $gtf > ${gtf.baseName}.bed -// """ -// } -// } -// -// /* -// * PREPROCESSING: Prepare genome intervals for filtering -// */ -// process MAKE_GENOME_FILTER { -// tag "$fasta" -// publishDir "${params.outdir}/genome", mode: params.publish_dir_mode -// -// input: -// path fasta from ch_fasta -// path blacklist from ch_blacklist.ifEmpty([]) -// -// output: -// path "$fasta" // FASTA FILE FOR IGV -// path '*.fai' // FAI INDEX FOR REFERENCE GENOME -// path '*.bed' into ch_genome_filter_regions // BED FILE WITHOUT BLACKLIST REGIONS -// path '*.sizes' into ch_genome_sizes_bigwig // CHROMOSOME SIZES FILE FOR BEDTOOLS -// -// script: -// blacklist_filter = params.blacklist ? "sortBed -i $blacklist -g ${fasta}.sizes | complementBed -i stdin -g ${fasta}.sizes" : "awk '{print \$1, '0' , \$2}' OFS='\t' ${fasta}.sizes" -// """ -// samtools faidx $fasta -// cut -f 1,2 ${fasta}.fai > ${fasta}.sizes -// $blacklist_filter > ${fasta}.include_regions.bed -// """ -// } -// -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// /* -- -- */ -// /* -- FASTQ QC -- */ -// /* -- -- */ -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// -// /* -// * STEP 1: FastQC -// */ -// process FASTQC { -// tag "$name" -// label 'process_medium' -// publishDir "${params.outdir}/fastqc", mode: params.publish_dir_mode, -// saveAs: { filename -> -// filename.endsWith('.zip') ? "zips/$filename" : filename -// } -// -// when: -// !params.skip_fastqc -// -// input: -// tuple val(name), path(reads) from ch_raw_reads_fastqc -// -// output: -// path '*.{zip,html}' into ch_fastqc_reports_mqc -// -// script: -// // Added soft-links to original fastqs for consistent naming in MultiQC -// if (params.single_end) { -// """ -// [ ! -f ${name}.fastq.gz ] && ln -s $reads ${name}.fastq.gz -// fastqc -q -t $task.cpus ${name}.fastq.gz -// """ -// } else { -// """ -// [ ! -f ${name}_1.fastq.gz ] && ln -s ${reads[0]} ${name}_1.fastq.gz -// [ ! -f ${name}_2.fastq.gz ] && ln -s ${reads[1]} ${name}_2.fastq.gz -// fastqc -q -t $task.cpus ${name}_1.fastq.gz -// fastqc -q -t $task.cpus ${name}_2.fastq.gz -// """ -// } -// } -// -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// /* -- -- */ -// /* -- ADAPTER TRIMMING -- */ -// /* -- -- */ -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// -// /* -// * STEP 2: Trim Galore! -// */ -// if (params.skip_trimming) { -// ch_trimmed_reads = ch_raw_reads_trimgalore -// ch_trimgalore_results_mqc = Channel.empty() -// ch_trimgalore_fastqc_reports_mqc = Channel.empty() -// } else { -// process TRIMGALORE { -// tag "$name" -// label 'process_high' -// publishDir "${params.outdir}/trim_galore", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (filename.endsWith('.html')) "fastqc/$filename" -// else if (filename.endsWith('.zip')) "fastqc/zips/$filename" -// else if (filename.endsWith('trimming_report.txt')) "logs/$filename" -// else params.save_trimmed ? filename : null -// } -// -// input: -// tuple val(name), path(reads) from ch_raw_reads_trimgalore -// -// output: -// tuple val(name), path('*.fq.gz') into ch_trimmed_reads -// path '*.txt' into ch_trimgalore_results_mqc -// path '*.{zip,html}' into ch_trimgalore_fastqc_reports_mqc -// -// script: -// // Calculate number of --cores for TrimGalore based on value of task.cpus -// // See: https://github.com/FelixKrueger/TrimGalore/blob/master/Changelog.md#version-060-release-on-1-mar-2019 -// // See: https://github.com/nf-core/atacseq/pull/65 -// def cores = 1 -// if (task.cpus) { -// cores = (task.cpus as int) - 4 -// if (params.single_end) cores = (task.cpus as int) - 3 -// if (cores < 1) cores = 1 -// if (cores > 4) cores = 4 -// } -// -// c_r1 = params.clip_r1 > 0 ? "--clip_r1 ${params.clip_r1}" : '' -// c_r2 = params.clip_r2 > 0 ? "--clip_r2 ${params.clip_r2}" : '' -// tpc_r1 = params.three_prime_clip_r1 > 0 ? "--three_prime_clip_r1 ${params.three_prime_clip_r1}" : '' -// tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' -// nextseq = params.trim_nextseq > 0 ? "--nextseq ${params.trim_nextseq}" : '' -// -// // Added soft-links to original fastqs for consistent naming in MultiQC -// if (params.single_end) { -// """ -// [ ! -f ${name}.fastq.gz ] && ln -s $reads ${name}.fastq.gz -// trim_galore --cores $cores --fastqc --gzip $c_r1 $tpc_r1 $nextseq ${name}.fastq.gz -// """ -// } else { -// """ -// [ ! -f ${name}_1.fastq.gz ] && ln -s ${reads[0]} ${name}_1.fastq.gz -// [ ! -f ${name}_2.fastq.gz ] && ln -s ${reads[1]} ${name}_2.fastq.gz -// trim_galore --cores $cores --paired --fastqc --gzip $c_r1 $c_r2 $tpc_r1 $tpc_r2 $nextseq ${name}_1.fastq.gz ${name}_2.fastq.gz -// """ -// } -// } -// } -// -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// /* -- -- */ -// /* -- ALIGN -- */ -// /* -- -- */ -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// -// /* -// * STEP 3.1: Map read(s) with bwa mem -// */ -// process BWA_MEM { -// tag "$name" -// label 'process_high' -// -// input: -// tuple val(name), path(reads) from ch_trimmed_reads -// path index from ch_bwa_index.collect() -// -// output: -// tuple val(name), path('*.bam') into ch_bwa_bam -// -// script: -// prefix = "${name}.Lb" -// rg = "\'@RG\\tID:${name}\\tSM:${name.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${name}\\tPU:1\'" -// if (params.seq_center) { -// rg = "\'@RG\\tID:${name}\\tSM:${name.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${name}\\tPU:1\\tCN:${params.seq_center}\'" -// } -// score = params.bwa_min_score ? "-T ${params.bwa_min_score}" : '' -// """ -// bwa mem \\ -// -t $task.cpus \\ -// -M \\ -// -R $rg \\ -// $score \\ -// ${index}/${bwa_base} \\ -// $reads \\ -// | samtools view -@ $task.cpus -b -h -F 0x0100 -O BAM -o ${prefix}.bam - -// """ -// } -// -// /* -// * STEP 3.2: Convert BAM to coordinate sorted BAM -// */ -// process SORT_BAM { -// tag "$name" -// label 'process_medium' -// if (params.save_align_intermeds) { -// publishDir path: "${params.outdir}/bwa/library", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (filename.endsWith('.flagstat')) "samtools_stats/$filename" -// else if (filename.endsWith('.idxstats')) "samtools_stats/$filename" -// else if (filename.endsWith('.stats')) "samtools_stats/$filename" -// else filename -// } -// } -// -// input: -// tuple val(name), path(bam) from ch_bwa_bam -// -// output: -// tuple val(name), path('*.sorted.{bam,bam.bai}') into ch_sort_bam_merge -// path '*.{flagstat,idxstats,stats}' into ch_sort_bam_flagstat_mqc -// -// script: -// prefix = "${name}.Lb" -// """ -// samtools sort -@ $task.cpus -o ${prefix}.sorted.bam -T $name $bam -// samtools index ${prefix}.sorted.bam -// samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat -// samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats -// samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats -// """ -// } -// // /////////////////////////////////////////////////////////////////////////////// // /////////////////////////////////////////////////////////////////////////////// // /* -- -- */ From 1da66990b603084ab15f0d0b88dbd8478e72c88d Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 14 Jul 2020 18:47:41 +0100 Subject: [PATCH 016/538] This is not the atacseq pipeline --- nextflow_schema.json | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index 5614b18c1..1d0dfff29 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -1,8 +1,8 @@ { "$schema": "http://json-schema.org/draft-07/schema", "$id": "https://raw.githubusercontent.com/nf-core/atacseq/master/nextflow_schema.json", - "title": "nf-core/atacseq pipeline parameters", - "description": "ATACSeq peak-calling and differential analysis pipeline.", + "title": "nf-core/chipseq pipeline parameters", + "description": "ChIP-seq peak-calling and differential analysis pipeline.", "type": "object", "properties": { "Input/output options": { @@ -537,4 +537,4 @@ "fa_icon": "fas fa-file-import" } } -} \ No newline at end of file +} From 2dd559ece569f9babc1aa6c67ad4b2a8e6f74c8f Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 14 Jul 2020 18:48:04 +0100 Subject: [PATCH 017/538] Initial commit of local modules --- modules/local/get_chrom_sizes.nf | 20 ++++++++++++++++++++ modules/local/gtf2bed.nf | 19 +++++++++++++++++++ modules/local/make_genome_filter.nf | 27 +++++++++++++++++++++++++++ 3 files changed, 66 insertions(+) create mode 100644 modules/local/get_chrom_sizes.nf create mode 100644 modules/local/gtf2bed.nf create mode 100644 modules/local/make_genome_filter.nf diff --git a/modules/local/get_chrom_sizes.nf b/modules/local/get_chrom_sizes.nf new file mode 100644 index 000000000..9c9a35f86 --- /dev/null +++ b/modules/local/get_chrom_sizes.nf @@ -0,0 +1,20 @@ +/* + * Get chromosome sizes from a fasta file + */ + process GET_CHROM_SIZES { + tag "$fasta" + publishDir "${params.outdir}/genome", mode: params.publish_dir_mode + + input: + path fasta + + output: + path '*.sizes', emit: sizes + path '*.fai', emit: fai + + script: + """ + samtools faidx $fasta + cut -f 1,2 ${fasta}.fai > ${fasta}.sizes + """ + } diff --git a/modules/local/gtf2bed.nf b/modules/local/gtf2bed.nf new file mode 100644 index 000000000..304eb6b03 --- /dev/null +++ b/modules/local/gtf2bed.nf @@ -0,0 +1,19 @@ +/* + * Convert GTF to BED file + */ +process GTF2BED { + tag "$gtf" + //label 'process_low' + publishDir "${params.outdir}/genome", mode: params.publish_dir_mode + + input: + path gtf + + output: + path '*.bed' + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + """ + gtf2bed $gtf > ${gtf.baseName}.bed + """ +} diff --git a/modules/local/make_genome_filter.nf b/modules/local/make_genome_filter.nf new file mode 100644 index 000000000..5e91d61ce --- /dev/null +++ b/modules/local/make_genome_filter.nf @@ -0,0 +1,27 @@ +/* + * Prepare genome intervals for filtering + * by removing regions in blacklist file + */ +process MAKE_GENOME_FILTER { + tag "$sizes" + publishDir "${params.outdir}/genome", mode: params.publish_dir_mode + + input: + path sizes + path blacklist + + output: + path '*.bed' + + script: + file_out = "${sizes.simpleName}.include_regions.bed" + if (params.blacklist) { + """ + sortBed -i $blacklist -g $sizes | complementBed -i stdin -g $sizes > $file_out + """ + } else { + """ + awk '{print \$1, '0' , \$2}' OFS='\t' $sizes > $file_out + """ + } +} From 5936c6f699fe0168b1bc2ea65f5e3e01ded1602d Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 14 Jul 2020 18:48:47 +0100 Subject: [PATCH 018/538] Add local nf-core modules to get pipeline working --- modules/nf-core/bwa_index.nf | 21 +++++++++++ modules/nf-core/bwa_mem.nf | 32 ++++++++++++++++ modules/nf-core/samtools_flagstats.nf | 0 modules/nf-core/samtools_idxstats.nf | 0 modules/nf-core/samtools_index.nf | 20 ++++++++++ modules/nf-core/samtools_sort.nf | 20 ++++++++++ modules/nf-core/samtools_stats.nf | 24 ++++++++++++ modules/nf-core/trimgalore.nf | 54 +++++++++++++++++++++++++++ 8 files changed, 171 insertions(+) create mode 100644 modules/nf-core/bwa_index.nf create mode 100644 modules/nf-core/bwa_mem.nf create mode 100644 modules/nf-core/samtools_flagstats.nf create mode 100644 modules/nf-core/samtools_idxstats.nf create mode 100644 modules/nf-core/samtools_index.nf create mode 100644 modules/nf-core/samtools_sort.nf create mode 100644 modules/nf-core/samtools_stats.nf create mode 100644 modules/nf-core/trimgalore.nf diff --git a/modules/nf-core/bwa_index.nf b/modules/nf-core/bwa_index.nf new file mode 100644 index 000000000..8f6e5f52e --- /dev/null +++ b/modules/nf-core/bwa_index.nf @@ -0,0 +1,21 @@ +/* + * Build BWA index + */ +process BWA_INDEX { + tag "$fasta" + //label 'process_high' + // publishDir path: { params.save_reference ? "${params.outdir}/genome" : params.outdir }, + // saveAs: { params.save_reference ? it : null }, mode: params.publish_dir_mode + + input: + path fasta + + output: + path 'BWAIndex' + + script: + """ + bwa index -a bwtsw $fasta + mkdir BWAIndex && mv ${fasta}* BWAIndex + """ +} diff --git a/modules/nf-core/bwa_mem.nf b/modules/nf-core/bwa_mem.nf new file mode 100644 index 000000000..a0c72a81d --- /dev/null +++ b/modules/nf-core/bwa_mem.nf @@ -0,0 +1,32 @@ +/* + * Map read(s) with bwa mem + */ +process BWA_MEM { + tag "$name" + label 'process_high' + + input: + tuple val(name), val(single_end), path(reads) + path index + + output: + tuple val(name), val(single_end), path('*.bam') + + script: + prefix = "${name}.Lb" + rg = "\'@RG\\tID:${name}\\tSM:${name.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${name}\\tPU:1\'" + if (params.seq_center) { + rg = "\'@RG\\tID:${name}\\tSM:${name.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${name}\\tPU:1\\tCN:${params.seq_center}\'" + } + score = params.bwa_min_score ? "-T ${params.bwa_min_score}" : '' + """ + bwa mem \\ + -t $task.cpus \\ + -M \\ + -R $rg \\ + $score \\ + ${index}/${params.bwa_base} \\ + $reads \\ + | samtools view -@ $task.cpus -b -h -F 0x0100 -O BAM -o ${prefix}.bam - + """ +} diff --git a/modules/nf-core/samtools_flagstats.nf b/modules/nf-core/samtools_flagstats.nf new file mode 100644 index 000000000..e69de29bb diff --git a/modules/nf-core/samtools_idxstats.nf b/modules/nf-core/samtools_idxstats.nf new file mode 100644 index 000000000..e69de29bb diff --git a/modules/nf-core/samtools_index.nf b/modules/nf-core/samtools_index.nf new file mode 100644 index 000000000..007b0b978 --- /dev/null +++ b/modules/nf-core/samtools_index.nf @@ -0,0 +1,20 @@ +/* + * Index BAM file + */ +process SAMTOOLS_INDEX { + tag "$name" + label 'process_medium' + publishDir path: "${params.outdir}", mode: params.publish_dir_mode + + input: + tuple val(name), val(single_end), path(bam) + + output: + tuple val(name), val(single_end), path('*.bai') + + script: + prefix = "${name}.Lb" + """ + samtools index ${prefix}.sorted.bam + """ +} diff --git a/modules/nf-core/samtools_sort.nf b/modules/nf-core/samtools_sort.nf new file mode 100644 index 000000000..2192ec88f --- /dev/null +++ b/modules/nf-core/samtools_sort.nf @@ -0,0 +1,20 @@ +/* + * Sort BAM file + */ +process SAMTOOLS_SORT { + tag "$name" + label 'process_medium' + publishDir path: "${params.outdir}", mode: params.publish_dir_mode + + input: + tuple val(name), val(single_end), path(bam) + + output: + tuple val(name), val(single_end), path('*.bam') + + script: + prefix = "${name}.Lb" + """ + samtools sort -@ $task.cpus -o ${prefix}.sorted.bam -T $name $bam + """ +} diff --git a/modules/nf-core/samtools_stats.nf b/modules/nf-core/samtools_stats.nf new file mode 100644 index 000000000..c470ee0fd --- /dev/null +++ b/modules/nf-core/samtools_stats.nf @@ -0,0 +1,24 @@ +/* + * Index BAM file + */ +process SAMTOOLS_STATS { + tag "$name" + label 'process_medium' + publishDir path: "${params.outdir}", mode: params.publish_dir_mode + + input: + tuple val(name), val(single_end), path(bam) + + output: + tuple val(name), val(single_end), path('*.stats'), emit: stats + tuple val(name), val(single_end), path('*.flagstat'), emit: flagstat + tuple val(name), val(single_end), path('*.idxstats'), emit: idxstats + + script: + prefix = "${name}.Lb" + """ + samtools stats $bam > ${bam}.stats + samtools flagstat $bam > ${bam}.flagstat + samtools idxstats $bam > ${bam}.idxstats + """ +} diff --git a/modules/nf-core/trimgalore.nf b/modules/nf-core/trimgalore.nf new file mode 100644 index 000000000..08cb5c0df --- /dev/null +++ b/modules/nf-core/trimgalore.nf @@ -0,0 +1,54 @@ +/* + * Trim Galore! + */ +process TRIMGALORE { + tag "$name" + label 'process_high' + publishDir "${params.outdir}/trim_galore", mode: params.publish_dir_mode, + saveAs: { filename -> + if (filename.endsWith('.html')) "fastqc/$filename" + else if (filename.endsWith('.zip')) "fastqc/zips/$filename" + else if (filename.endsWith('trimming_report.txt')) "logs/$filename" + else params.save_trimmed ? filename : null + } + + input: + tuple val(name), val(single_end), path(reads) + + output: + tuple val(name), val(single_end), path('*.fq.gz'), emit: reads + path '*.txt', emit: log + path '*.{zip,html}', emit: fastqc + + script: + // Calculate number of --cores for TrimGalore based on value of task.cpus + // See: https://github.com/FelixKrueger/TrimGalore/blob/master/Changelog.md#version-060-release-on-1-mar-2019 + // See: https://github.com/nf-core/atacseq/pull/65 + def cores = 1 + if (task.cpus) { + cores = (task.cpus as int) - 4 + if (single_end) cores = (task.cpus as int) - 3 + if (cores < 1) cores = 1 + if (cores > 4) cores = 4 + } + + c_r1 = params.clip_r1 > 0 ? "--clip_r1 ${params.clip_r1}" : '' + c_r2 = params.clip_r2 > 0 ? "--clip_r2 ${params.clip_r2}" : '' + tpc_r1 = params.three_prime_clip_r1 > 0 ? "--three_prime_clip_r1 ${params.three_prime_clip_r1}" : '' + tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' + nextseq = params.trim_nextseq > 0 ? "--nextseq ${params.trim_nextseq}" : '' + + // Added soft-links to original fastqs for consistent naming in MultiQC + if (single_end) { + """ + [ ! -f ${name}.fastq.gz ] && ln -s $reads ${name}.fastq.gz + trim_galore --cores $cores --fastqc --gzip $c_r1 $tpc_r1 $nextseq ${name}.fastq.gz + """ + } else { + """ + [ ! -f ${name}_1.fastq.gz ] && ln -s ${reads[0]} ${name}_1.fastq.gz + [ ! -f ${name}_2.fastq.gz ] && ln -s ${reads[1]} ${name}_2.fastq.gz + trim_galore --cores $cores --paired --fastqc --gzip $c_r1 $c_r2 $tpc_r1 $tpc_r2 $nextseq ${name}_1.fastq.gz ${name}_2.fastq.gz + """ + } +} From 602985e2fdd31d3d84f5059b28679aad6ccda541 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 14 Jul 2020 21:32:52 +0100 Subject: [PATCH 019/538] Remove cache for testing --- conf/base.config | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/conf/base.config b/conf/base.config index 789af0d6c..ea4261cd6 100644 --- a/conf/base.config +++ b/conf/base.config @@ -41,8 +41,8 @@ process { withLabel:error_ignore { errorStrategy = 'ignore' } - withName:GET_SOFTWARE_VERSIONS { - cache = false - } + //withName:GET_SOFTWARE_VERSIONS { + // cache = false + //} } From aeab6c21d1b6370898cfc555ebad90d2260b6d38 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 14 Jul 2020 21:33:02 +0100 Subject: [PATCH 020/538] Add in more processes --- main.nf | 165 +++++++++----------------------------------------------- 1 file changed, 24 insertions(+), 141 deletions(-) diff --git a/main.nf b/main.nf index 2ccfeea21..45cada21a 100755 --- a/main.nf +++ b/main.nf @@ -148,12 +148,13 @@ log.info "-\033[2m----------------------------------------------------\033[0m-" /* * Include local pipeline modules */ -include { CHECK_SAMPLESHEET - get_samplesheet_paths +include { CHECK_SAMPLESHEET; + get_samplesheet_paths; get_samplesheet_design } from './modules/local/check_samplesheet' params(params) include { GTF2BED } from './modules/local/gtf2bed' params(params) include { GET_CHROM_SIZES } from './modules/local/get_chrom_sizes' params(params) include { MAKE_GENOME_FILTER } from './modules/local/make_genome_filter' params(params) +include { FILTER_BAM } from './modules/local/filter_bam' params(params) include { OUTPUT_DOCUMENTATION } from './modules/local/output_documentation' params(params) include { GET_SOFTWARE_VERSIONS } from './modules/local/get_software_versions' params(params) @@ -166,7 +167,11 @@ include { TRIMGALORE } from './modules/nf-core/trimgalore' params(params) include { BWA_MEM } from './modules/nf-core/bwa_mem' params(params) include { SAMTOOLS_SORT } from './modules/nf-core/samtools_sort' params(params) include { SAMTOOLS_INDEX } from './modules/nf-core/samtools_index' params(params) -include { SAMTOOLS_STATS } from './modules/nf-core/samtools_stats' params(params) +include { SAMTOOLS_STATS as SAMTOOLS_STATS_MAP; + SAMTOOLS_STATS as SAMTOOLS_STATS_MARKDUPLICATES } from './modules/nf-core/samtools_stats' params(params) +include { PICARD_MERGESAMFILES } from './modules/nf-core/picard_mergesamfiles' params(params) +include { PICARD_MARKDUPLICATES } from './modules/nf-core/picard_markduplicates' params(params) +//include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/picard_collectmultiplemetrics' params(params) include { MULTIQC } from './modules/nf-core/multiqc' params(params) /* @@ -216,7 +221,22 @@ workflow { */ BWA_MEM(ch_trimmed_reads, ch_bwa_index.collect()) SAMTOOLS_SORT(BWA_MEM.out) | SAMTOOLS_INDEX - SAMTOOLS_STATS(SAMTOOLS_SORT.out) + SAMTOOLS_STATS_MAP(SAMTOOLS_SORT.out) + + /* + * MERGE RESEQUENCED BAM FILES + */ + SAMTOOLS_SORT + .out + .map { it -> [ it[0].split('_')[0..-2].join('_'), it[1], it[2] ] } + .groupTuple(by: [0, 1]) + .map { it -> [ it[0], it[1], it[2].flatten() ] } + .set { ch_sort_bam } + PICARD_MERGESAMFILES(ch_sort_bam) + PICARD_MARKDUPLICATES(PICARD_MERGESAMFILES.out).bam | SAMTOOLS_STATS_MARKDUPLICATES + FILTER_BAM(PICARD_MARKDUPLICATES.out.bam, + MAKE_GENOME_FILTER.out.collect(), + ch_bamtools_filter_config) // Fix getting name sorted BAM here for PE/SE /* * PIPELINE REPORTING @@ -252,143 +272,6 @@ workflow.onComplete { // /////////////////////////////////////////////////////////////////////////////// // // /* -// * STEP 4.1: Merge BAM files for all libraries from same sample replicate -// */ -// ch_sort_bam_merge -// .map { it -> [ it[0].split('_')[0..-2].join('_'), it[1] ] } -// .groupTuple(by: [0]) -// .map { it -> [ it[0], it[1].flatten() ] } -// .set { ch_sort_bam_merge } -// -// process MERGED_BAM { -// tag "$name" -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (filename.endsWith('.flagstat')) "samtools_stats/$filename" -// else if (filename.endsWith('.idxstats')) "samtools_stats/$filename" -// else if (filename.endsWith('.stats')) "samtools_stats/$filename" -// else if (filename.endsWith('.metrics.txt')) "picard_metrics/$filename" -// else params.save_align_intermeds ? filename : null -// } -// -// input: -// tuple val(name), path(bams) from ch_sort_bam_merge -// -// output: -// tuple val(name), path("*${prefix}.sorted.{bam,bam.bai}") into ch_merge_bam_filter, -// ch_merge_bam_preseq -// path '*.{flagstat,idxstats,stats}' into ch_merge_bam_stats_mqc -// path '*.txt' into ch_merge_bam_metrics_mqc -// -// script: -// prefix = "${name}.mLb.mkD" -// bam_files = bams.findAll { it.toString().endsWith('.bam') }.sort() -// def avail_mem = 3 -// if (!task.memory) { -// log.info '[Picard MarkDuplicates] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' -// } else { -// avail_mem = task.memory.toGiga() -// } -// if (bam_files.size() > 1) { -// """ -// picard -Xmx${avail_mem}g MergeSamFiles \\ -// ${'INPUT='+bam_files.join(' INPUT=')} \\ -// OUTPUT=${name}.sorted.bam \\ -// SORT_ORDER=coordinate \\ -// VALIDATION_STRINGENCY=LENIENT \\ -// TMP_DIR=tmp -// samtools index ${name}.sorted.bam -// -// picard -Xmx${avail_mem}g MarkDuplicates \\ -// INPUT=${name}.sorted.bam \\ -// OUTPUT=${prefix}.sorted.bam \\ -// ASSUME_SORTED=true \\ -// REMOVE_DUPLICATES=false \\ -// METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt \\ -// VALIDATION_STRINGENCY=LENIENT \\ -// TMP_DIR=tmp -// -// samtools index ${prefix}.sorted.bam -// samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats -// samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat -// samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats -// """ -// } else { -// """ -// picard -Xmx${avail_mem}g MarkDuplicates \\ -// INPUT=${bam_files[0]} \\ -// OUTPUT=${prefix}.sorted.bam \\ -// ASSUME_SORTED=true \\ -// REMOVE_DUPLICATES=false \\ -// METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt \\ -// VALIDATION_STRINGENCY=LENIENT \\ -// TMP_DIR=tmp -// -// samtools index ${prefix}.sorted.bam -// samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats -// samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat -// samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats -// """ -// } -// } -// -// /* -// * STEP 4.2: Filter BAM file at merged library-level -// */ -// process MERGED_BAM_FILTER { -// tag "$name" -// label 'process_medium' -// publishDir path: "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (params.single_end || params.save_align_intermeds) { -// if (filename.endsWith('.flagstat')) "samtools_stats/$filename" -// else if (filename.endsWith('.idxstats')) "samtools_stats/$filename" -// else if (filename.endsWith('.stats')) "samtools_stats/$filename" -// else if (filename.endsWith('.sorted.bam')) filename -// else if (filename.endsWith('.sorted.bam.bai')) filename -// else null -// } -// } -// -// input: -// tuple val(name), path(bam) from ch_merge_bam_filter -// path bed from ch_genome_filter_regions.collect() -// path bamtools_filter_config from ch_bamtools_filter_config -// -// output: -// tuple val(name), path('*.{bam,bam.bai}') into ch_filter_bam -// tuple val(name), path('*.flagstat') into ch_filter_bam_flagstat -// path '*.{idxstats,stats}' into ch_filter_bam_stats_mqc -// -// script: -// prefix = params.single_end ? "${name}.mLb.clN" : "${name}.mLb.flT" -// filter_params = params.single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' -// dup_params = params.keep_dups ? '' : '-F 0x0400' -// multimap_params = params.keep_multi_map ? '' : '-q 1' -// blacklist_params = params.blacklist ? "-L $bed" : '' -// name_sort_bam = params.single_end ? '' : "samtools sort -n -@ $task.cpus -o ${prefix}.bam -T $prefix ${prefix}.sorted.bam" -// """ -// samtools view \\ -// $filter_params \\ -// $dup_params \\ -// $multimap_params \\ -// $blacklist_params \\ -// -b ${bam[0]} \\ -// | bamtools filter \\ -// -out ${prefix}.sorted.bam \\ -// -script $bamtools_filter_config -// -// samtools index ${prefix}.sorted.bam -// samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat -// samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats -// samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats -// -// $name_sort_bam -// """ -// } -// -// /* // * STEP 4.3: Remove orphan reads from paired-end BAM file // */ // if (params.single_end) { From 8942bb95a7db58f75385523cf2e3a74988c43339 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 14 Jul 2020 21:33:18 +0100 Subject: [PATCH 021/538] Add in more local processes --- modules/local/filter_bam.nf | 55 +++++++++++++++++++++++++++++++++++++ 1 file changed, 55 insertions(+) create mode 100644 modules/local/filter_bam.nf diff --git a/modules/local/filter_bam.nf b/modules/local/filter_bam.nf new file mode 100644 index 000000000..17549eb32 --- /dev/null +++ b/modules/local/filter_bam.nf @@ -0,0 +1,55 @@ +/* + * Filter BAM file + */ +process FILTER_BAM { + tag "$name" + label 'process_medium' + publishDir path: "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode, + saveAs: { filename -> + if (single_end || params.save_align_intermeds) { + if (filename.endsWith('.flagstat')) "samtools_stats/$filename" + else if (filename.endsWith('.idxstats')) "samtools_stats/$filename" + else if (filename.endsWith('.stats')) "samtools_stats/$filename" + else if (filename.endsWith('.sorted.bam')) filename + else if (filename.endsWith('.sorted.bam.bai')) filename + else null + } + } + + input: + tuple val(name), val(single_end), path(bam) + path bed + path filter_config + + output: + tuple val(name), val(single_end), path('*.bam'), emit: bam + tuple val(name), val(single_end), path('*.bai'), emit: bai + tuple val(name), val(single_end), path('*.stats'), emit: stats + tuple val(name), val(single_end), path('*.flagstat'), emit: flagstat + tuple val(name), val(single_end), path('*.idxstats'), emit: idxstats + + script: + prefix = single_end ? "${name}.mLb.clN" : "${name}.mLb.flT" + filter_params = single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' + dup_params = params.keep_dups ? '' : '-F 0x0400' + multimap_params = params.keep_multi_map ? '' : '-q 1' + blacklist_params = params.blacklist ? "-L $bed" : '' + name_sort_bam = single_end ? '' : "samtools sort -n -@ $task.cpus -o ${prefix}.bam -T $prefix ${prefix}.sorted.bam" + """ + samtools view \\ + $filter_params \\ + $dup_params \\ + $multimap_params \\ + $blacklist_params \\ + -b ${bam[0]} \\ + | bamtools filter \\ + -out ${prefix}.sorted.bam \\ + -script $filter_config + samtools index ${prefix}.sorted.bam + samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat + samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats + samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats + + $name_sort_bam + """ +} From b61f3cdbeb124cca70318c62715b1d91e3848377 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 14 Jul 2020 21:33:28 +0100 Subject: [PATCH 022/538] Add picard modules --- .../nf-core/picard_collectmultiplemetrics.nf | 0 modules/nf-core/picard_markduplicates.nf | 34 +++++++++++++++++ modules/nf-core/picard_mergesamfiles.nf | 38 +++++++++++++++++++ 3 files changed, 72 insertions(+) create mode 100644 modules/nf-core/picard_collectmultiplemetrics.nf create mode 100644 modules/nf-core/picard_markduplicates.nf create mode 100644 modules/nf-core/picard_mergesamfiles.nf diff --git a/modules/nf-core/picard_collectmultiplemetrics.nf b/modules/nf-core/picard_collectmultiplemetrics.nf new file mode 100644 index 000000000..e69de29bb diff --git a/modules/nf-core/picard_markduplicates.nf b/modules/nf-core/picard_markduplicates.nf new file mode 100644 index 000000000..45e5c116b --- /dev/null +++ b/modules/nf-core/picard_markduplicates.nf @@ -0,0 +1,34 @@ +/* + * Picard MarkDuplicates + */ +process PICARD_MARKDUPLICATES { + tag "$name" + label 'process_medium' + publishDir "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode + + input: + tuple val(name), val(single_end), path(bam) + + output: + tuple val(name), val(single_end), path("*.bam"), emit: bam + tuple val(name), val(single_end), path("*.txt"), emit: metrics + + script: + prefix = "${name}.mLb.mkD" + def avail_mem = 3 + if (!task.memory) { + log.info '[Picard MarkDuplicates] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' + } else { + avail_mem = task.memory.toGiga() + } + """ + picard -Xmx${avail_mem}g MarkDuplicates \\ + INPUT=$bam \\ + OUTPUT=${prefix}.sorted.bam \\ + ASSUME_SORTED=true \\ + REMOVE_DUPLICATES=false \\ + METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt \\ + VALIDATION_STRINGENCY=LENIENT \\ + TMP_DIR=tmp + """ +} diff --git a/modules/nf-core/picard_mergesamfiles.nf b/modules/nf-core/picard_mergesamfiles.nf new file mode 100644 index 000000000..785512d38 --- /dev/null +++ b/modules/nf-core/picard_mergesamfiles.nf @@ -0,0 +1,38 @@ +/* + * Picard MergeSamFiles + */ +process PICARD_MERGESAMFILES { + tag "$name" + label 'process_medium' + publishDir "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode + + input: + tuple val(name), val(single_end), path(bams) + + output: + tuple val(name), val(single_end), path("*.bam") + + script: + prefix = "${name}.mLb.mkD" + bam_files = bams.sort() + def avail_mem = 3 + if (!task.memory) { + log.info '[Picard MergeSamFiles] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' + } else { + avail_mem = task.memory.toGiga() + } + if (bam_files.size() > 1) { + """ + picard -Xmx${avail_mem}g MergeSamFiles \\ + ${'INPUT='+bam_files.join(' INPUT=')} \\ + OUTPUT=${name}.sorted.bam \\ + SORT_ORDER=coordinate \\ + VALIDATION_STRINGENCY=LENIENT \\ + TMP_DIR=tmp + """ + } else { + """ + ln -s ${bam_files[0]} ${name}.sorted.bam + """ + } +} From 7961437a5053ca04b5680e6b78b126dc4dcd71bd Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 15 Jul 2020 14:48:06 +0100 Subject: [PATCH 023/538] Add subworkflows --- main.nf | 153 +++++++++++++++++++++++++++++++++++++++----------------- 1 file changed, 108 insertions(+), 45 deletions(-) diff --git a/main.nf b/main.nf index 45cada21a..4c1c0f5a5 100755 --- a/main.nf +++ b/main.nf @@ -71,7 +71,7 @@ if (params.bwa_index) { params.bwa_base = params.bwa_index.substring(lastPath+1) Channel .fromPath(bwa_dir, checkIfExists: true) - .set { ch_bwa_index } + .set { ch_index } } // Save AWS IGenomes file containing annotation version @@ -82,12 +82,12 @@ if (params.anno_readme && file(params.anno_readme).exists()) { // If --gtf is supplied along with --genome // Make gene bed from supplied --gtf instead of using iGenomes one automatically -def MAKE_BED = false +def MakeBED = false if (!params.gene_bed) { - MAKE_BED = true + MakeBED = true } else if (params.genome && params.gtf) { if (params.genomes[ params.genome ].gtf != params.gtf) { - MAKE_BED = true + MakeBED = true } } @@ -167,26 +167,27 @@ include { TRIMGALORE } from './modules/nf-core/trimgalore' params(params) include { BWA_MEM } from './modules/nf-core/bwa_mem' params(params) include { SAMTOOLS_SORT } from './modules/nf-core/samtools_sort' params(params) include { SAMTOOLS_INDEX } from './modules/nf-core/samtools_index' params(params) -include { SAMTOOLS_STATS as SAMTOOLS_STATS_MAP; - SAMTOOLS_STATS as SAMTOOLS_STATS_MARKDUPLICATES } from './modules/nf-core/samtools_stats' params(params) +// include { SAMTOOLS_STATS as SAMTOOLS_STATS_MAP; +// SAMTOOLS_STATS as SAMTOOLS_STATS_MARKDUPLICATES } from './modules/nf-core/samtools_stats' params(params) +include { SAMTOOLS_STATS } from './modules/nf-core/samtools_stats' params(params) include { PICARD_MERGESAMFILES } from './modules/nf-core/picard_mergesamfiles' params(params) include { PICARD_MARKDUPLICATES } from './modules/nf-core/picard_markduplicates' params(params) //include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/picard_collectmultiplemetrics' params(params) include { MULTIQC } from './modules/nf-core/multiqc' params(params) /* - * Run the workflow + * Check input samplesheet and get read channels */ -workflow { +workflow CHECK_INPUTS { + take: + ch_input // /path/to/samplesheet.csv - /* - * READ IN SAMPLESHEET - */ + main: CHECK_SAMPLESHEET(ch_input) .reads .splitCsv(header:true, sep:',') .map { get_samplesheet_paths(it, params.single_end) } - .set { ch_raw_reads } + .set { ch_reads } CHECK_SAMPLESHEET .out @@ -195,48 +196,110 @@ workflow { .map { get_samplesheet_design(it) } .set { ch_design } - /* - * PREPARE GENOME FILES - */ - if (!params.bwa_index) { BWA_INDEX(ch_fasta).set { ch_bwa_index } } - if (MAKE_BED) { GTF2BED(ch_gtf).set { ch_gene_bed } } - MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta).sizes, ch_blacklist.ifEmpty([])) + emit: + reads = ch_reads + design = ch_design +} - /* - * READ QC & TRIMMING - */ - FASTQC(ch_raw_reads) - if (params.skip_trimming) { - ch_trimmed_reads = ch_raw_reads - ch_trimgalore_log_mqc = Channel.empty() - ch_trimgalore_fastqc_mqc = Channel.empty() - } else { - TRIMGALORE(ch_raw_reads).reads.set { ch_trimmed_reads } - ch_trimgalore_log_mqc = TRIMGALORE.out.log - ch_trimgalore_fastqc_mqc = TRIMGALORE.out.fastqc +/* + * Read QC and trimming + */ +workflow QC_TRIM_READS { + take: + ch_reads // [ val(name), val(single_end), [ reads ] ] + skip_fastqc // boolean: true/false + skip_trimming // boolean: true/false + + main: + fastqc = Channel.empty() + if (!skip_fastqc) { + fastqc = FASTQC(ch_reads) } - /* - * MAP READS & BAM QC - */ - BWA_MEM(ch_trimmed_reads, ch_bwa_index.collect()) - SAMTOOLS_SORT(BWA_MEM.out) | SAMTOOLS_INDEX - SAMTOOLS_STATS_MAP(SAMTOOLS_SORT.out) + ch_trimmed_reads = ch_reads + trim_log = Channel.empty() + trim_fastqc = Channel.empty() + if (!skip_trimming) { + TRIMGALORE(ch_reads).reads.set { ch_trimmed_reads } + trim_log = TRIMGALORE.out.log + trim_fastqc = TRIMGALORE.out.fastqc + } - /* - * MERGE RESEQUENCED BAM FILES - */ - SAMTOOLS_SORT + emit: + fastqc = fastqc + reads = ch_trimmed_reads + trim_log = trim_log + trim_fastqc = trim_fastqc +} + +/* + * Sort, index BAM file and run samtools stats, flagstat and idxstats + */ +workflow SORT_BAM { + take: + ch_bam // [ val(name), val(single_end), bam ] + + main: + SAMTOOLS_SORT(ch_bam) | SAMTOOLS_INDEX + SAMTOOLS_STATS(SAMTOOLS_SORT.out, SAMTOOLS_INDEX.out) + + emit: + bam = SAMTOOLS_SORT.out + bai = SAMTOOLS_INDEX.out + stats = SAMTOOLS_STATS.out.stats + flagstat = SAMTOOLS_STATS.out.flagstat + idxstats = SAMTOOLS_STATS.out.idxstats +} + +/* + * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats + */ +workflow MAP_READS { + take: + ch_reads // [ val(name), val(single_end), [ reads ] ] + ch_index // [ /path/to/index ] + + main: + BWA_MEM(ch_reads, ch_index.collect()) + SORT_BAM(BWA_MEM.out) + + emit: + bam = SORT_BAM.out.bam + bai = SORT_BAM.out.bai + stats = SORT_BAM.out.stats + flagstat = SORT_BAM.out.flagstat + idxstats = SORT_BAM.out.idxstats +} + +workflow { + + // READ IN SAMPLESHEET, VALIDATE AND STAGE INPUT FILES + CHECK_INPUTS(ch_input) + + // PREPARE GENOME FILES + if (!params.bwa_index) { BWA_INDEX(ch_fasta).set { ch_index } } + if (MakeBED) { GTF2BED(ch_gtf).set { ch_gene_bed } } + MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta).sizes, ch_blacklist.ifEmpty([])) + + // READ QC & TRIMMING + QC_TRIM_READS(CHECK_INPUTS.out.reads, params.skip_fastqc, params.skip_trimming) + + // MAP READS & BAM QC + MAP_READS(QC_TRIM_READS.out.reads, ch_index.collect()) + + // MERGE RESEQUENCED BAM FILES + MAP_READS .out + .bam .map { it -> [ it[0].split('_')[0..-2].join('_'), it[1], it[2] ] } .groupTuple(by: [0, 1]) .map { it -> [ it[0], it[1], it[2].flatten() ] } .set { ch_sort_bam } - PICARD_MERGESAMFILES(ch_sort_bam) - PICARD_MARKDUPLICATES(PICARD_MERGESAMFILES.out).bam | SAMTOOLS_STATS_MARKDUPLICATES - FILTER_BAM(PICARD_MARKDUPLICATES.out.bam, - MAKE_GENOME_FILTER.out.collect(), - ch_bamtools_filter_config) // Fix getting name sorted BAM here for PE/SE + //PICARD_MERGESAMFILES(ch_sort_bam) + // PICARD_MARKDUPLICATES(PICARD_MERGESAMFILES.out).bam | SAMTOOLS_STATS_MARKDUPLICATES + // FILTER_BAM(PICARD_MARKDUPLICATES.out.bam, + // MAKE_GENOME_FILTER.out.collect(), + // ch_bamtools_filter_config) // Fix getting name sorted BAM here for PE/SE /* * PIPELINE REPORTING From 1f30058063f4e9389c7186f5f9b57179ae16af83 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 15 Jul 2020 14:48:20 +0100 Subject: [PATCH 024/538] Stage index files --- modules/nf-core/samtools_stats.nf | 1 + 1 file changed, 1 insertion(+) diff --git a/modules/nf-core/samtools_stats.nf b/modules/nf-core/samtools_stats.nf index c470ee0fd..309c78199 100644 --- a/modules/nf-core/samtools_stats.nf +++ b/modules/nf-core/samtools_stats.nf @@ -8,6 +8,7 @@ process SAMTOOLS_STATS { input: tuple val(name), val(single_end), path(bam) + tuple val(name), val(single_end), path(bai) output: tuple val(name), val(single_end), path('*.stats'), emit: stats From 7563b22e83567de4d96a8b9a42331531e6c17bef Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 15 Jul 2020 15:00:25 +0100 Subject: [PATCH 025/538] Join BAM and BAI to fix resume bug --- main.nf | 5 ++--- 1 file changed, 2 insertions(+), 3 deletions(-) diff --git a/main.nf b/main.nf index 4c1c0f5a5..5db74137d 100755 --- a/main.nf +++ b/main.nf @@ -167,8 +167,6 @@ include { TRIMGALORE } from './modules/nf-core/trimgalore' params(params) include { BWA_MEM } from './modules/nf-core/bwa_mem' params(params) include { SAMTOOLS_SORT } from './modules/nf-core/samtools_sort' params(params) include { SAMTOOLS_INDEX } from './modules/nf-core/samtools_index' params(params) -// include { SAMTOOLS_STATS as SAMTOOLS_STATS_MAP; -// SAMTOOLS_STATS as SAMTOOLS_STATS_MARKDUPLICATES } from './modules/nf-core/samtools_stats' params(params) include { SAMTOOLS_STATS } from './modules/nf-core/samtools_stats' params(params) include { PICARD_MERGESAMFILES } from './modules/nf-core/picard_mergesamfiles' params(params) include { PICARD_MARKDUPLICATES } from './modules/nf-core/picard_markduplicates' params(params) @@ -241,7 +239,7 @@ workflow SORT_BAM { main: SAMTOOLS_SORT(ch_bam) | SAMTOOLS_INDEX - SAMTOOLS_STATS(SAMTOOLS_SORT.out, SAMTOOLS_INDEX.out) + SAMTOOLS_STATS(SAMTOOLS_SORT.out.join(SAMTOOLS_INDEX.out, by: [0,1])) emit: bam = SAMTOOLS_SORT.out @@ -308,6 +306,7 @@ workflow { ch_output_docs, ch_output_docs_images) + OUTPUT_DOCUMENTATION.dump() GET_SOFTWARE_VERSIONS() // MULTIQC( From 2dcc8b2f6b296b85d505edba60a3fbad9423483b Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 15 Jul 2020 15:00:43 +0100 Subject: [PATCH 026/538] Stage BAI too --- modules/nf-core/samtools_stats.nf | 5 ++--- 1 file changed, 2 insertions(+), 3 deletions(-) diff --git a/modules/nf-core/samtools_stats.nf b/modules/nf-core/samtools_stats.nf index 309c78199..1621bd141 100644 --- a/modules/nf-core/samtools_stats.nf +++ b/modules/nf-core/samtools_stats.nf @@ -7,9 +7,8 @@ process SAMTOOLS_STATS { publishDir path: "${params.outdir}", mode: params.publish_dir_mode input: - tuple val(name), val(single_end), path(bam) - tuple val(name), val(single_end), path(bai) - + tuple val(name), val(single_end), path(bam), path(bai) + output: tuple val(name), val(single_end), path('*.stats'), emit: stats tuple val(name), val(single_end), path('*.flagstat'), emit: flagstat From 083415a9bb25efd4a60eb5828df70e6d386acacf Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 15 Jul 2020 15:41:05 +0100 Subject: [PATCH 027/538] Get params into FastQC --- main.nf | 33 ++++++++++++++++++++------------- modules/nf-core/fastqc.nf | 31 ++++++++++++++++++++----------- 2 files changed, 40 insertions(+), 24 deletions(-) diff --git a/main.nf b/main.nf index 5db74137d..6523fbe45 100755 --- a/main.nf +++ b/main.nf @@ -178,7 +178,7 @@ include { MULTIQC } from './modules/nf-core/multiqc' params(params) */ workflow CHECK_INPUTS { take: - ch_input // /path/to/samplesheet.csv + ch_input // file: /path/to/samplesheet.csv main: CHECK_SAMPLESHEET(ch_input) @@ -204,28 +204,35 @@ workflow CHECK_INPUTS { */ workflow QC_TRIM_READS { take: - ch_reads // [ val(name), val(single_end), [ reads ] ] + ch_reads // channel: [ val(name), val(single_end), [ reads ] ] skip_fastqc // boolean: true/false skip_trimming // boolean: true/false + fastqc_args // string: valid arguments accepted by FastQC main: - fastqc = Channel.empty() + fastqc_html = Channel.empty() + fastqc_zip = Channel.empty() + fastqc_version = Channel.empty() if (!skip_fastqc) { - fastqc = FASTQC(ch_reads) + FASTQC(ch_reads, fastqc_args).html.set { fastqc_html } + fastqc_zip = FASTQC.out.zip + fastqc_version = FASTQC.out.version } - ch_trimmed_reads = ch_reads + ch_trim_reads = ch_reads trim_log = Channel.empty() trim_fastqc = Channel.empty() if (!skip_trimming) { - TRIMGALORE(ch_reads).reads.set { ch_trimmed_reads } + TRIMGALORE(ch_reads).reads.set { ch_trim_reads } trim_log = TRIMGALORE.out.log trim_fastqc = TRIMGALORE.out.fastqc } emit: - fastqc = fastqc - reads = ch_trimmed_reads + fastqc_html = fastqc_html + fastqc_zip = fastqc_zip + fastqc_version = fastqc_version + reads = ch_trim_reads trim_log = trim_log trim_fastqc = trim_fastqc } @@ -235,7 +242,7 @@ workflow QC_TRIM_READS { */ workflow SORT_BAM { take: - ch_bam // [ val(name), val(single_end), bam ] + ch_bam // channel: [ val(name), val(single_end), bam ] main: SAMTOOLS_SORT(ch_bam) | SAMTOOLS_INDEX @@ -254,8 +261,8 @@ workflow SORT_BAM { */ workflow MAP_READS { take: - ch_reads // [ val(name), val(single_end), [ reads ] ] - ch_index // [ /path/to/index ] + ch_reads // channel: [ val(name), val(single_end), [ reads ] ] + ch_index // channel: [ /path/to/index ] main: BWA_MEM(ch_reads, ch_index.collect()) @@ -280,7 +287,8 @@ workflow { MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta).sizes, ch_blacklist.ifEmpty([])) // READ QC & TRIMMING - QC_TRIM_READS(CHECK_INPUTS.out.reads, params.skip_fastqc, params.skip_trimming) + params.fastqc_args = "--quiet" + QC_TRIM_READS(CHECK_INPUTS.out.reads, params.skip_fastqc, params.skip_trimming, params.fastqc_args) // MAP READS & BAM QC MAP_READS(QC_TRIM_READS.out.reads, ch_index.collect()) @@ -306,7 +314,6 @@ workflow { ch_output_docs, ch_output_docs_images) - OUTPUT_DOCUMENTATION.dump() GET_SOFTWARE_VERSIONS() // MULTIQC( diff --git a/modules/nf-core/fastqc.nf b/modules/nf-core/fastqc.nf index 5129ab488..5ba3e503a 100755 --- a/modules/nf-core/fastqc.nf +++ b/modules/nf-core/fastqc.nf @@ -1,32 +1,41 @@ -/* - * FastQC - */ +def MODULE = "fastqc" +params.publish_dir = MODULE +params.publish_results = "default" + process FASTQC { - tag "$name" - label 'process_medium' - publishDir "${params.outdir}/fastqc", mode: params.publish_dir_mode, + publishDir "${params.outdir}/${params.publish_dir}", + mode: params.publish_dir_mode, saveAs: { filename -> - filename.indexOf(".zip") > 0 ? "zips/$filename" : "$filename" - } + if (params.publish_results == "none") null + else filename } + + //container "docker.pkg.github.com/nf-core/$MODULE" + + //conda "${moduleDir}/environment.yml" input: tuple val(name), val(single_end), path(reads) + val (fastqc_args) output: - path "*.{zip,html}" + tuple val(name), val(single_end), path("*.html"), emit: html + tuple val(name), val(single_end), path("*.zip"), emit: zip + path "*.version.txt", emit: version script: // Add soft-links to original FastQs for consistent naming in pipeline if (single_end) { """ [ ! -f ${name}.fastq.gz ] && ln -s $reads ${name}.fastq.gz - fastqc --quiet --threads $task.cpus ${name}.fastq.gz + fastqc $fastqc_args --threads $task.cpus ${name}.fastq.gz + fastqc --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > fastqc.version.txt """ } else { """ [ ! -f ${name}_1.fastq.gz ] && ln -s ${reads[0]} ${name}_1.fastq.gz [ ! -f ${name}_2.fastq.gz ] && ln -s ${reads[1]} ${name}_2.fastq.gz - fastqc --quiet --threads $task.cpus ${name}_1.fastq.gz ${name}_2.fastq.gz + fastqc $fastqc_args --threads $task.cpus ${name}_1.fastq.gz ${name}_2.fastq.gz + fastqc --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > fastqc.version.txt """ } } From 6debaf137f5ac7bf9c6bd5e71194f7f920ff1b0c Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 20 Jul 2020 10:18:16 +0100 Subject: [PATCH 028/538] Store changes from last week --- main.nf | 121 ++++++++++++++++++++---------- modules/local/filter_bam.nf | 41 ++++------ modules/nf-core/fastqc.nf | 8 +- modules/nf-core/samtools_index.nf | 5 +- modules/nf-core/samtools_sort.nf | 27 +++++-- 5 files changed, 124 insertions(+), 78 deletions(-) diff --git a/main.nf b/main.nf index 6523fbe45..37fc7a6e3 100755 --- a/main.nf +++ b/main.nf @@ -150,33 +150,33 @@ log.info "-\033[2m----------------------------------------------------\033[0m-" */ include { CHECK_SAMPLESHEET; get_samplesheet_paths; - get_samplesheet_design } from './modules/local/check_samplesheet' params(params) -include { GTF2BED } from './modules/local/gtf2bed' params(params) -include { GET_CHROM_SIZES } from './modules/local/get_chrom_sizes' params(params) -include { MAKE_GENOME_FILTER } from './modules/local/make_genome_filter' params(params) -include { FILTER_BAM } from './modules/local/filter_bam' params(params) -include { OUTPUT_DOCUMENTATION } from './modules/local/output_documentation' params(params) -include { GET_SOFTWARE_VERSIONS } from './modules/local/get_software_versions' params(params) + get_samplesheet_design } from './modules/local/check_samplesheet' +include { GTF2BED } from './modules/local/gtf2bed' +include { GET_CHROM_SIZES } from './modules/local/get_chrom_sizes' +include { MAKE_GENOME_FILTER } from './modules/local/make_genome_filter' +include { FILTER_BAM } from './modules/local/filter_bam' +include { OUTPUT_DOCUMENTATION } from './modules/local/output_documentation' +include { GET_SOFTWARE_VERSIONS } from './modules/local/get_software_versions' /* * Include nf-core modules */ -include { FASTQC } from './modules/nf-core/fastqc' params(params) -include { BWA_INDEX } from './modules/nf-core/bwa_index' params(params) -include { TRIMGALORE } from './modules/nf-core/trimgalore' params(params) -include { BWA_MEM } from './modules/nf-core/bwa_mem' params(params) -include { SAMTOOLS_SORT } from './modules/nf-core/samtools_sort' params(params) -include { SAMTOOLS_INDEX } from './modules/nf-core/samtools_index' params(params) -include { SAMTOOLS_STATS } from './modules/nf-core/samtools_stats' params(params) -include { PICARD_MERGESAMFILES } from './modules/nf-core/picard_mergesamfiles' params(params) -include { PICARD_MARKDUPLICATES } from './modules/nf-core/picard_markduplicates' params(params) -//include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/picard_collectmultiplemetrics' params(params) -include { MULTIQC } from './modules/nf-core/multiqc' params(params) +include { FASTQC } from './modules/nf-core/fastqc' addParams(fastqc_args : "--quiet") +include { BWA_INDEX } from './modules/nf-core/bwa_index' +include { TRIMGALORE } from './modules/nf-core/trimgalore' +include { BWA_MEM } from './modules/nf-core/bwa_mem' +include { SAMTOOLS_SORT } from './modules/nf-core/samtools_sort' +include { SAMTOOLS_INDEX } from './modules/nf-core/samtools_index' +include { SAMTOOLS_STATS } from './modules/nf-core/samtools_stats' +include { PICARD_MERGESAMFILES } from './modules/nf-core/picard_mergesamfiles' +include { PICARD_MARKDUPLICATES } from './modules/nf-core/picard_markduplicates' +//include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/picard_collectmultiplemetrics' +include { MULTIQC } from './modules/nf-core/multiqc' /* * Check input samplesheet and get read channels */ -workflow CHECK_INPUTS { +workflow CHECK_INPUT { take: ch_input // file: /path/to/samplesheet.csv @@ -202,19 +202,20 @@ workflow CHECK_INPUTS { /* * Read QC and trimming */ -workflow QC_TRIM_READS { +workflow QC_TRIM { take: ch_reads // channel: [ val(name), val(single_end), [ reads ] ] skip_fastqc // boolean: true/false skip_trimming // boolean: true/false - fastqc_args // string: valid arguments accepted by FastQC + //fastqc_args // string: valid arguments accepted by FastQC main: fastqc_html = Channel.empty() fastqc_zip = Channel.empty() fastqc_version = Channel.empty() if (!skip_fastqc) { - FASTQC(ch_reads, fastqc_args).html.set { fastqc_html } + //FASTQC(ch_reads, fastqc_args).html.set { fastqc_html } + FASTQC(ch_reads).html.set { fastqc_html } fastqc_zip = FASTQC.out.zip fastqc_version = FASTQC.out.version } @@ -259,7 +260,7 @@ workflow SORT_BAM { /* * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats */ -workflow MAP_READS { +workflow ALIGN { take: ch_reads // channel: [ val(name), val(single_end), [ reads ] ] ch_index // channel: [ /path/to/index ] @@ -276,10 +277,57 @@ workflow MAP_READS { idxstats = SORT_BAM.out.idxstats } +/* + * Picard MarkDuplicates, sort, index BAM file and run samtools stats, flagstat and idxstats + */ +workflow MARKDUP { + take: + ch_bam // channel: [ val(name), val(single_end), bam ] + + main: + PICARD_MARKDUPLICATES(ch_bam) + SAMTOOLS_INDEX(PICARD_MARKDUPLICATES.out.bam) + SAMTOOLS_STATS(PICARD_MARKDUPLICATES.out.bam.join(SAMTOOLS_INDEX.out, by: [0,1])) + + emit: + bam = PICARD_MARKDUPLICATES.out.bam + metrics = PICARD_MARKDUPLICATES.out.metrics + bai = SAMTOOLS_INDEX.out + stats = SAMTOOLS_STATS.out.stats + flagstat = SAMTOOLS_STATS.out.flagstat + idxstats = SAMTOOLS_STATS.out.idxstats +} + +/* + * Filter BAM file + */ +workflow FILTER_BAM { + take: + ch_bam // channel: [ val(name), val(single_end), bam ] + ch_bai // channel: [ val(name), val(single_end), bai ] + ch_bed // channel: [ bed ] + config // file: BAMtools filter JSON config file + + main: + FILTER_BAM(ch_bam, + ch_bai, + ch_bed, + config) // Fix getting name sorted BAM here for PE/SE + SAMTOOLS_INDEX(FILTER_BAM.out.bam) + SAMTOOLS_STATS(FILTER_BAM.out.bam.join(SAMTOOLS_INDEX.out, by: [0,1])) + + emit: + bam = FILTER_BAM.out.bam + bai = SAMTOOLS_INDEX.out + stats = SAMTOOLS_STATS.out.stats + flagstat = SAMTOOLS_STATS.out.flagstat + idxstats = SAMTOOLS_STATS.out.idxstats +} + workflow { // READ IN SAMPLESHEET, VALIDATE AND STAGE INPUT FILES - CHECK_INPUTS(ch_input) + CHECK_INPUT(ch_input) // PREPARE GENOME FILES if (!params.bwa_index) { BWA_INDEX(ch_fasta).set { ch_index } } @@ -287,34 +335,31 @@ workflow { MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta).sizes, ch_blacklist.ifEmpty([])) // READ QC & TRIMMING - params.fastqc_args = "--quiet" - QC_TRIM_READS(CHECK_INPUTS.out.reads, params.skip_fastqc, params.skip_trimming, params.fastqc_args) + //params.fastqc_args = "--quiet" + //QC_TRIM_READS(CHECK_INPUTS.out.reads, params.skip_fastqc, params.skip_trimming, params.fastqc_args) + QC_TRIM(CHECK_INPUT.out.reads, params.skip_fastqc, params.skip_trimming) // MAP READS & BAM QC - MAP_READS(QC_TRIM_READS.out.reads, ch_index.collect()) + ALIGN(QC_TRIM.out.reads, ch_index.collect()) // MERGE RESEQUENCED BAM FILES - MAP_READS + ALIGN .out .bam .map { it -> [ it[0].split('_')[0..-2].join('_'), it[1], it[2] ] } .groupTuple(by: [0, 1]) .map { it -> [ it[0], it[1], it[2].flatten() ] } .set { ch_sort_bam } - //PICARD_MERGESAMFILES(ch_sort_bam) - // PICARD_MARKDUPLICATES(PICARD_MERGESAMFILES.out).bam | SAMTOOLS_STATS_MARKDUPLICATES - // FILTER_BAM(PICARD_MARKDUPLICATES.out.bam, + PICARD_MERGESAMFILES(ch_sort_bam) | MARKDUP + + // FILTER BAM FILES + // FILTER_BAM(MARK_DUPS.out.bam, // MAKE_GENOME_FILTER.out.collect(), // ch_bamtools_filter_config) // Fix getting name sorted BAM here for PE/SE - /* - * PIPELINE REPORTING - */ - OUTPUT_DOCUMENTATION( - ch_output_docs, - ch_output_docs_images) - + // PIPELINE TEMPLATE REPORTING GET_SOFTWARE_VERSIONS() + OUTPUT_DOCUMENTATION(ch_output_docs,ch_output_docs_images) // MULTIQC( // summary, diff --git a/modules/local/filter_bam.nf b/modules/local/filter_bam.nf index 17549eb32..22b14cd12 100644 --- a/modules/local/filter_bam.nf +++ b/modules/local/filter_bam.nf @@ -4,52 +4,41 @@ process FILTER_BAM { tag "$name" label 'process_medium' - publishDir path: "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode, - saveAs: { filename -> - if (single_end || params.save_align_intermeds) { - if (filename.endsWith('.flagstat')) "samtools_stats/$filename" - else if (filename.endsWith('.idxstats')) "samtools_stats/$filename" - else if (filename.endsWith('.stats')) "samtools_stats/$filename" - else if (filename.endsWith('.sorted.bam')) filename - else if (filename.endsWith('.sorted.bam.bai')) filename - else null - } - } + publishDir path: "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode + // saveAs: { filename -> + // if (single_end || params.save_align_intermeds) { + // else if (filename.endsWith('.sorted.bam')) filename + // else if (filename.endsWith('.sorted.bam.bai')) filename + // else null + // } + // } input: tuple val(name), val(single_end), path(bam) + tuple val(name), val(single_end), path(bai) path bed - path filter_config + path config output: tuple val(name), val(single_end), path('*.bam'), emit: bam - tuple val(name), val(single_end), path('*.bai'), emit: bai - tuple val(name), val(single_end), path('*.stats'), emit: stats - tuple val(name), val(single_end), path('*.flagstat'), emit: flagstat - tuple val(name), val(single_end), path('*.idxstats'), emit: idxstats - + script: prefix = single_end ? "${name}.mLb.clN" : "${name}.mLb.flT" filter_params = single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' dup_params = params.keep_dups ? '' : '-F 0x0400' multimap_params = params.keep_multi_map ? '' : '-q 1' blacklist_params = params.blacklist ? "-L $bed" : '' - name_sort_bam = single_end ? '' : "samtools sort -n -@ $task.cpus -o ${prefix}.bam -T $prefix ${prefix}.sorted.bam" + //name_sort_bam = single_end ? '' : "samtools sort -n -@ $task.cpus -o ${prefix}.bam -T $prefix ${prefix}.sorted.bam" """ samtools view \\ $filter_params \\ $dup_params \\ $multimap_params \\ $blacklist_params \\ - -b ${bam[0]} \\ + -b $bam \\ | bamtools filter \\ -out ${prefix}.sorted.bam \\ - -script $filter_config - samtools index ${prefix}.sorted.bam - samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat - samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats - samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats - - $name_sort_bam + -script $config """ } +//$name_sort_bam diff --git a/modules/nf-core/fastqc.nf b/modules/nf-core/fastqc.nf index 5ba3e503a..8aa52929f 100755 --- a/modules/nf-core/fastqc.nf +++ b/modules/nf-core/fastqc.nf @@ -1,8 +1,10 @@ def MODULE = "fastqc" params.publish_dir = MODULE params.publish_results = "default" +//params.fastqc_args = '' process FASTQC { + tag "$name" publishDir "${params.outdir}/${params.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> @@ -15,7 +17,7 @@ process FASTQC { input: tuple val(name), val(single_end), path(reads) - val (fastqc_args) + //val (fastqc_args) output: tuple val(name), val(single_end), path("*.html"), emit: html @@ -27,14 +29,14 @@ process FASTQC { if (single_end) { """ [ ! -f ${name}.fastq.gz ] && ln -s $reads ${name}.fastq.gz - fastqc $fastqc_args --threads $task.cpus ${name}.fastq.gz + fastqc $params.fastqc_args --threads $task.cpus ${name}.fastq.gz fastqc --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > fastqc.version.txt """ } else { """ [ ! -f ${name}_1.fastq.gz ] && ln -s ${reads[0]} ${name}_1.fastq.gz [ ! -f ${name}_2.fastq.gz ] && ln -s ${reads[1]} ${name}_2.fastq.gz - fastqc $fastqc_args --threads $task.cpus ${name}_1.fastq.gz ${name}_2.fastq.gz + fastqc $params.fastqc_args --threads $task.cpus ${name}_1.fastq.gz ${name}_2.fastq.gz fastqc --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > fastqc.version.txt """ } diff --git a/modules/nf-core/samtools_index.nf b/modules/nf-core/samtools_index.nf index 007b0b978..a09bae039 100644 --- a/modules/nf-core/samtools_index.nf +++ b/modules/nf-core/samtools_index.nf @@ -5,7 +5,7 @@ process SAMTOOLS_INDEX { tag "$name" label 'process_medium' publishDir path: "${params.outdir}", mode: params.publish_dir_mode - + input: tuple val(name), val(single_end), path(bam) @@ -13,8 +13,7 @@ process SAMTOOLS_INDEX { tuple val(name), val(single_end), path('*.bai') script: - prefix = "${name}.Lb" """ - samtools index ${prefix}.sorted.bam + samtools index $bam """ } diff --git a/modules/nf-core/samtools_sort.nf b/modules/nf-core/samtools_sort.nf index 2192ec88f..e61390762 100644 --- a/modules/nf-core/samtools_sort.nf +++ b/modules/nf-core/samtools_sort.nf @@ -1,20 +1,31 @@ -/* - * Sort BAM file - */ +def MODULE = "samtools_sort" +params.publish_dir = MODULE +params.publish_results = "default" +params.suffix = '' +//params.samtools_sort_args = '' + process SAMTOOLS_SORT { - tag "$name" - label 'process_medium' - publishDir path: "${params.outdir}", mode: params.publish_dir_mode + publishDir "${params.outdir}/${params.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (params.publish_results == "none") null + else filename } + + container "docker.pkg.github.com/nf-core/$MODULE" + conda "${moduleDir}/environment.yml" input: tuple val(name), val(single_end), path(bam) - + //val (samtools_sort_args) + output: tuple val(name), val(single_end), path('*.bam') + path "*.version.txt", emit: version script: - prefix = "${name}.Lb" + prefix = "${name}.${suffix}" """ samtools sort -@ $task.cpus -o ${prefix}.sorted.bam -T $name $bam + samtools --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > samtools.version.txt """ } From 28ad670ad2509436d28a2bb1cf465cbdf08e813e Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 20 Jul 2020 13:31:32 +0100 Subject: [PATCH 029/538] Provide module options via map --- main.nf | 112 +++++++++++++++-------------- modules/local/check_samplesheet.nf | 25 ++++--- modules/nf-core/fastqc.nf | 34 +++++---- 3 files changed, 91 insertions(+), 80 deletions(-) diff --git a/main.nf b/main.nf index 37fc7a6e3..ba00e7c7a 100755 --- a/main.nf +++ b/main.nf @@ -191,7 +191,7 @@ workflow CHECK_INPUT { .out .controls .splitCsv(header:true, sep:',') - .map { get_samplesheet_design(it) } + .map { get_samplesheet_design(it, params.single_end) } .set { ch_design } emit: @@ -204,38 +204,38 @@ workflow CHECK_INPUT { */ workflow QC_TRIM { take: - ch_reads // channel: [ val(name), val(single_end), [ reads ] ] - skip_fastqc // boolean: true/false - skip_trimming // boolean: true/false - //fastqc_args // string: valid arguments accepted by FastQC + ch_reads // channel: [ val(metadata), [ reads ] ] + skip_fastqc // boolean: true/false + skip_trimming // boolean: true/false + fastqc_opts // map: options for FastQC module + trimgalore_opts // map: options for TrimGalore! module main: fastqc_html = Channel.empty() fastqc_zip = Channel.empty() fastqc_version = Channel.empty() if (!skip_fastqc) { - //FASTQC(ch_reads, fastqc_args).html.set { fastqc_html } - FASTQC(ch_reads).html.set { fastqc_html } + FASTQC(ch_reads, fastqc_opts).html.set { fastqc_html } fastqc_zip = FASTQC.out.zip fastqc_version = FASTQC.out.version } - ch_trim_reads = ch_reads - trim_log = Channel.empty() - trim_fastqc = Channel.empty() - if (!skip_trimming) { - TRIMGALORE(ch_reads).reads.set { ch_trim_reads } - trim_log = TRIMGALORE.out.log - trim_fastqc = TRIMGALORE.out.fastqc - } + // ch_trim_reads = ch_reads + // trim_log = Channel.empty() + // trim_fastqc = Channel.empty() + // if (!skip_trimming) { + // TRIMGALORE(ch_reads, trimgalore_opts).reads.set { ch_trim_reads } + // trim_log = TRIMGALORE.out.log + // trim_fastqc = TRIMGALORE.out.fastqc + // } emit: fastqc_html = fastqc_html fastqc_zip = fastqc_zip fastqc_version = fastqc_version - reads = ch_trim_reads - trim_log = trim_log - trim_fastqc = trim_fastqc + // reads = ch_trim_reads + // trim_log = trim_log + // trim_fastqc = trim_fastqc } /* @@ -329,43 +329,47 @@ workflow { // READ IN SAMPLESHEET, VALIDATE AND STAGE INPUT FILES CHECK_INPUT(ch_input) - // PREPARE GENOME FILES - if (!params.bwa_index) { BWA_INDEX(ch_fasta).set { ch_index } } - if (MakeBED) { GTF2BED(ch_gtf).set { ch_gene_bed } } - MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta).sizes, ch_blacklist.ifEmpty([])) - + // // PREPARE GENOME FILES + // if (!params.bwa_index) { BWA_INDEX(ch_fasta).set { ch_index } } + // if (MakeBED) { GTF2BED(ch_gtf).set { ch_gene_bed } } + // MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta).sizes, ch_blacklist.ifEmpty([])) + // // READ QC & TRIMMING - //params.fastqc_args = "--quiet" - //QC_TRIM_READS(CHECK_INPUTS.out.reads, params.skip_fastqc, params.skip_trimming, params.fastqc_args) - QC_TRIM(CHECK_INPUT.out.reads, params.skip_fastqc, params.skip_trimming) - - // MAP READS & BAM QC - ALIGN(QC_TRIM.out.reads, ch_index.collect()) - - // MERGE RESEQUENCED BAM FILES - ALIGN - .out - .bam - .map { it -> [ it[0].split('_')[0..-2].join('_'), it[1], it[2] ] } - .groupTuple(by: [0, 1]) - .map { it -> [ it[0], it[1], it[2].flatten() ] } - .set { ch_sort_bam } - PICARD_MERGESAMFILES(ch_sort_bam) | MARKDUP - - // FILTER BAM FILES - // FILTER_BAM(MARK_DUPS.out.bam, - // MAKE_GENOME_FILTER.out.collect(), - // ch_bamtools_filter_config) // Fix getting name sorted BAM here for PE/SE - - // PIPELINE TEMPLATE REPORTING - GET_SOFTWARE_VERSIONS() - OUTPUT_DOCUMENTATION(ch_output_docs,ch_output_docs_images) - - // MULTIQC( - // summary, - // FASTQC.out, - // ch_multiqc_config - // ) + def fastqc_opts = [:] + fastqc_opts.args = "--quiet" + fastqc_opts.suffix = "test" + fastqc_opts.publish_dir = "fastqc_test" + fastqc_opts.publish_results = "all" + def trimgalore_opts = [:] + QC_TRIM(CHECK_INPUT.out.reads, params.skip_fastqc, params.skip_trimming, fastqc_opts, trimgalore_opts) + // + // // MAP READS & BAM QC + // ALIGN(QC_TRIM.out.reads, ch_index.collect()) + // + // // MERGE RESEQUENCED BAM FILES + // ALIGN + // .out + // .bam + // .map { it -> [ it[0].split('_')[0..-2].join('_'), it[1], it[2] ] } + // .groupTuple(by: [0, 1]) + // .map { it -> [ it[0], it[1], it[2].flatten() ] } + // .set { ch_sort_bam } + // PICARD_MERGESAMFILES(ch_sort_bam) | MARKDUP + // + // // FILTER BAM FILES + // // FILTER_BAM(MARK_DUPS.out.bam, + // // MAKE_GENOME_FILTER.out.collect(), + // // ch_bamtools_filter_config) // Fix getting name sorted BAM here for PE/SE + // + // // PIPELINE TEMPLATE REPORTING + // GET_SOFTWARE_VERSIONS() + // OUTPUT_DOCUMENTATION(ch_output_docs,ch_output_docs_images) + // + // // MULTIQC( + // // summary, + // // FASTQC.out, + // // ch_multiqc_config + // // ) } /* diff --git a/modules/local/check_samplesheet.nf b/modules/local/check_samplesheet.nf index a8c011a8c..97ceae3bb 100755 --- a/modules/local/check_samplesheet.nf +++ b/modules/local/check_samplesheet.nf @@ -18,22 +18,31 @@ process CHECK_SAMPLESHEET { """ } -// Function to get list of [ sample, single_end?, [ fastq_1, fastq_2 ] ] +// Function to get list of [ meta, [ fastq_1, fastq_2 ] ] def get_samplesheet_paths(LinkedHashMap row, boolean single_end) { - def sample = row.sample_id - def fastq_1 = row.fastq_1 - def fastq_2 = row.fastq_2 + def meta = [:] + meta.id = row.sample_id + meta.single_end = single_end def array = [] if (single_end) { - array = [ sample, single_end, [ file(fastq_1, checkIfExists: true) ] ] + array = [ meta, [ file(row.fastq_1, checkIfExists: true) ] ] } else { - array = [ sample, single_end, [ file(fastq_1, checkIfExists: true), file(fastq_2, checkIfExists: true) ] ] + array = [ meta, [ file(row.fastq_1, checkIfExists: true), file(row.fastq_2, checkIfExists: true) ] ] } return array } // Function to get list of [sample, control, antibody, replicatesExist?, multipleGroups?] -def get_samplesheet_design(LinkedHashMap row) { - return [ row.sample_id, row.control_id, row.antibody, row.replicatesExist.toBoolean(), row.multipleGroups.toBoolean() ] +def get_samplesheet_design(LinkedHashMap row, boolean single_end) { + def meta = [:] + meta.id = row.sample_id + meta.single_end = single_end + meta.antibody = row.antibody + meta.control_id = row.control_id + meta.reps_exist = row.replicatesExist.toBoolean() + meta.groups_exist = row.multipleGroups.toBoolean() + + //return [ row.sample_id, row.control_id, row.antibody, row.replicatesExist.toBoolean(), row.multipleGroups.toBoolean() ] + return meta } diff --git a/modules/nf-core/fastqc.nf b/modules/nf-core/fastqc.nf index 8aa52929f..8d293adbe 100755 --- a/modules/nf-core/fastqc.nf +++ b/modules/nf-core/fastqc.nf @@ -1,42 +1,40 @@ def MODULE = "fastqc" -params.publish_dir = MODULE -params.publish_results = "default" -//params.fastqc_args = '' process FASTQC { - tag "$name" - publishDir "${params.outdir}/${params.publish_dir}", + tag "$meta.id" + publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (params.publish_results == "none") null + if (opts.publish_results == "none") null else filename } - //container "docker.pkg.github.com/nf-core/$MODULE" + container = "quay.io/biocontainers/fastqc:0.11.9--0" - //conda "${moduleDir}/environment.yml" + conda (params.conda ? "${moduleDir}/environment.yml" : null) input: - tuple val(name), val(single_end), path(reads) - //val (fastqc_args) + tuple val(meta), path(reads) + val opts output: - tuple val(name), val(single_end), path("*.html"), emit: html - tuple val(name), val(single_end), path("*.zip"), emit: zip + tuple val(meta), path("*.html"), emit: html + tuple val(meta), path("*.zip"), emit: zip path "*.version.txt", emit: version script: // Add soft-links to original FastQs for consistent naming in pipeline - if (single_end) { + prefix = opts.suffix ? "${meta.id}.${opts.suffix}" : "${meta.id}" + if (meta.single_end) { """ - [ ! -f ${name}.fastq.gz ] && ln -s $reads ${name}.fastq.gz - fastqc $params.fastqc_args --threads $task.cpus ${name}.fastq.gz + [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz + fastqc $opts.args --threads $task.cpus ${prefix}.fastq.gz fastqc --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > fastqc.version.txt """ } else { """ - [ ! -f ${name}_1.fastq.gz ] && ln -s ${reads[0]} ${name}_1.fastq.gz - [ ! -f ${name}_2.fastq.gz ] && ln -s ${reads[1]} ${name}_2.fastq.gz - fastqc $params.fastqc_args --threads $task.cpus ${name}_1.fastq.gz ${name}_2.fastq.gz + [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz + [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz + fastqc $opts.args --threads $task.cpus ${prefix}_1.fastq.gz ${prefix}_2.fastq.gz fastqc --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > fastqc.version.txt """ } From 61a18faff01259c19d3b5fa06923d8cd34134661 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 20 Jul 2020 14:17:23 +0100 Subject: [PATCH 030/538] Put module settings in a central config --- conf/modules.config | 15 +++++++++++++++ main.nf | 7 +------ nextflow.config | 3 +++ 3 files changed, 19 insertions(+), 6 deletions(-) create mode 100644 conf/modules.config diff --git a/conf/modules.config b/conf/modules.config new file mode 100644 index 000000000..5938f6a41 --- /dev/null +++ b/conf/modules.config @@ -0,0 +1,15 @@ +/* + * ------------------------------------------------- + * Nextflow config file for module specific-options + * ------------------------------------------------- + */ +params { + modules { + 'fastqc' { + args = "--quiet" + suffix = "" + publish_dir = "fastqc" + publish_results = "all" + } + } +} diff --git a/main.nf b/main.nf index ba00e7c7a..fd8d285b3 100755 --- a/main.nf +++ b/main.nf @@ -335,13 +335,8 @@ workflow { // MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta).sizes, ch_blacklist.ifEmpty([])) // // READ QC & TRIMMING - def fastqc_opts = [:] - fastqc_opts.args = "--quiet" - fastqc_opts.suffix = "test" - fastqc_opts.publish_dir = "fastqc_test" - fastqc_opts.publish_results = "all" def trimgalore_opts = [:] - QC_TRIM(CHECK_INPUT.out.reads, params.skip_fastqc, params.skip_trimming, fastqc_opts, trimgalore_opts) + QC_TRIM(CHECK_INPUT.out.reads, params.skip_fastqc, params.skip_trimming, params.modules['fastqc'], trimgalore_opts) // // // MAP READS & BAM QC // ALIGN(QC_TRIM.out.reads, ch_index.collect()) diff --git a/nextflow.config b/nextflow.config index 23d6bc75c..7ff44b819 100644 --- a/nextflow.config +++ b/nextflow.config @@ -101,6 +101,9 @@ process.container = 'nfcore/chipseq:dev' // Load base.config by default for all pipelines includeConfig 'conf/base.config' +// Load modules.config by default for all pipelines +includeConfig 'conf/modules.config' + // Load nf-core custom profiles from different Institutions try { includeConfig "${params.custom_config_base}/nfcore_custom.config" From 73dc5a635bc35707006b31137da08df2f286d550 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 20 Jul 2020 18:28:32 +0100 Subject: [PATCH 031/538] Add in TrimGalore --- conf/modules.config | 6 +++ main.nf | 45 ++++++++++++-------- modules/nf-core/fastqc.nf | 4 +- modules/nf-core/trim_galore.nf | 78 ++++++++++++++++++++++++++++++++++ modules/nf-core/trimgalore.nf | 54 ----------------------- 5 files changed, 114 insertions(+), 73 deletions(-) create mode 100644 modules/nf-core/trim_galore.nf delete mode 100644 modules/nf-core/trimgalore.nf diff --git a/conf/modules.config b/conf/modules.config index 5938f6a41..3846281ce 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -11,5 +11,11 @@ params { publish_dir = "fastqc" publish_results = "all" } + 'trim_galore' { + args = "--fastqc" + suffix = "" + publish_dir = "trim_galore" + publish_results = "all" + } } } diff --git a/main.nf b/main.nf index fd8d285b3..41e134a5e 100755 --- a/main.nf +++ b/main.nf @@ -161,9 +161,9 @@ include { GET_SOFTWARE_VERSIONS } from './modules/local/get_software_versions' /* * Include nf-core modules */ -include { FASTQC } from './modules/nf-core/fastqc' addParams(fastqc_args : "--quiet") +include { FASTQC } from './modules/nf-core/fastqc' +include { TRIM_GALORE } from './modules/nf-core/trim_galore' include { BWA_INDEX } from './modules/nf-core/bwa_index' -include { TRIMGALORE } from './modules/nf-core/trimgalore' include { BWA_MEM } from './modules/nf-core/bwa_mem' include { SAMTOOLS_SORT } from './modules/nf-core/samtools_sort' include { SAMTOOLS_INDEX } from './modules/nf-core/samtools_index' @@ -220,22 +220,29 @@ workflow QC_TRIM { fastqc_version = FASTQC.out.version } - // ch_trim_reads = ch_reads - // trim_log = Channel.empty() - // trim_fastqc = Channel.empty() - // if (!skip_trimming) { - // TRIMGALORE(ch_reads, trimgalore_opts).reads.set { ch_trim_reads } - // trim_log = TRIMGALORE.out.log - // trim_fastqc = TRIMGALORE.out.fastqc - // } + ch_trim_reads = ch_reads + trim_html = Channel.empty() + trim_zip = Channel.empty() + trim_log = Channel.empty() + trim_version = Channel.empty() + if (!skip_trimming) { + TRIM_GALORE(ch_reads, trimgalore_opts).reads.set { ch_trim_reads } + trim_html = TRIM_GALORE.out.html + trim_zip = TRIM_GALORE.out.zip + trim_log = TRIM_GALORE.out.log + trim_version = TRIM_GALORE.out.version + } emit: - fastqc_html = fastqc_html - fastqc_zip = fastqc_zip - fastqc_version = fastqc_version - // reads = ch_trim_reads - // trim_log = trim_log - // trim_fastqc = trim_fastqc + fastqc_html + fastqc_zip + fastqc_version + + reads = ch_trim_reads + trim_html + trim_zip + trim_log + trim_version } /* @@ -335,8 +342,10 @@ workflow { // MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta).sizes, ch_blacklist.ifEmpty([])) // // READ QC & TRIMMING - def trimgalore_opts = [:] - QC_TRIM(CHECK_INPUT.out.reads, params.skip_fastqc, params.skip_trimming, params.modules['fastqc'], trimgalore_opts) + nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' + params.modules['trim_galore'].args += nextseq + QC_TRIM(CHECK_INPUT.out.reads, params.skip_fastqc, params.skip_trimming, params.modules['fastqc'], params.modules['trim_galore']) + // // // MAP READS & BAM QC // ALIGN(QC_TRIM.out.reads, ch_index.collect()) diff --git a/modules/nf-core/fastqc.nf b/modules/nf-core/fastqc.nf index 8d293adbe..46b5cff9e 100755 --- a/modules/nf-core/fastqc.nf +++ b/modules/nf-core/fastqc.nf @@ -2,13 +2,15 @@ def MODULE = "fastqc" process FASTQC { tag "$meta.id" + label 'process_medium' publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> if (opts.publish_results == "none") null else filename } - container = "quay.io/biocontainers/fastqc:0.11.9--0" + container "quay.io/biocontainers/fastqc:0.11.9--0" + //container "https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0" conda (params.conda ? "${moduleDir}/environment.yml" : null) diff --git a/modules/nf-core/trim_galore.nf b/modules/nf-core/trim_galore.nf new file mode 100644 index 000000000..f8adc913c --- /dev/null +++ b/modules/nf-core/trim_galore.nf @@ -0,0 +1,78 @@ +def MODULE = "trim_galore" + +process TRIM_GALORE { + tag "$meta.id" + label 'process_high' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else filename } + + container "quay.io/biocontainers/trim-galore:0.6.5--0" + //container "https://depot.galaxyproject.org/singularity/trim-galore:0.6.5--0" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) + + input: + tuple val(meta), path(reads) + val opts + + output: + tuple val(meta), path("*.fq.gz"), emit: reads + tuple val(meta), path("*.html"), emit: html optional true + tuple val(meta), path("*.zip"), emit: zip optional true + tuple val(meta), path("*.txt"), emit: log + path "*.version.txt", emit: version + + script: + // Calculate number of --cores for TrimGalore based on value of task.cpus + // See: https://github.com/FelixKrueger/TrimGalore/blob/master/Changelog.md#version-060-release-on-1-mar-2019 + // See: https://github.com/nf-core/atacseq/pull/65 + def cores = 1 + if (task.cpus) { + cores = (task.cpus as int) - 4 + if (meta.single_end) cores = (task.cpus as int) - 3 + if (cores < 1) cores = 1 + if (cores > 4) cores = 4 + } + + // Clipping presets have to be evaluated in the context of SE/PE + c_r1 = params.clip_r1 > 0 ? "--clip_r1 ${params.clip_r1}" : '' + c_r2 = params.clip_r2 > 0 ? "--clip_r2 ${params.clip_r2}" : '' + tpc_r1 = params.three_prime_clip_r1 > 0 ? "--three_prime_clip_r1 ${params.three_prime_clip_r1}" : '' + tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' + + // Added soft-links to original fastqs for consistent naming in MultiQC + prefix = opts.suffix ? "${meta.id}.${opts.suffix}" : "${meta.id}" + if (meta.single_end) { + """ + [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz + trim_galore \\ + $opts.args \\ + --cores $cores \\ + --gzip \\ + $c_r1 \\ + $tpc_r1 \\ + ${prefix}.fastq.gz + trim_galore --version > trim_galore.version.txt + """ + } else { + """ + [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz + [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz + trim_galore \\ + $opts.args \\ + --cores $cores \\ + --paired \\ + --gzip \\ + $c_r1 \\ + $c_r2 \\ + $tpc_r1 \\ + $tpc_r2 \\ + ${prefix}_1.fastq.gz \\ + ${prefix}_2.fastq.gz + trim_galore --version > trim_galore.version.txt + """ + } +} diff --git a/modules/nf-core/trimgalore.nf b/modules/nf-core/trimgalore.nf deleted file mode 100644 index 08cb5c0df..000000000 --- a/modules/nf-core/trimgalore.nf +++ /dev/null @@ -1,54 +0,0 @@ -/* - * Trim Galore! - */ -process TRIMGALORE { - tag "$name" - label 'process_high' - publishDir "${params.outdir}/trim_galore", mode: params.publish_dir_mode, - saveAs: { filename -> - if (filename.endsWith('.html')) "fastqc/$filename" - else if (filename.endsWith('.zip')) "fastqc/zips/$filename" - else if (filename.endsWith('trimming_report.txt')) "logs/$filename" - else params.save_trimmed ? filename : null - } - - input: - tuple val(name), val(single_end), path(reads) - - output: - tuple val(name), val(single_end), path('*.fq.gz'), emit: reads - path '*.txt', emit: log - path '*.{zip,html}', emit: fastqc - - script: - // Calculate number of --cores for TrimGalore based on value of task.cpus - // See: https://github.com/FelixKrueger/TrimGalore/blob/master/Changelog.md#version-060-release-on-1-mar-2019 - // See: https://github.com/nf-core/atacseq/pull/65 - def cores = 1 - if (task.cpus) { - cores = (task.cpus as int) - 4 - if (single_end) cores = (task.cpus as int) - 3 - if (cores < 1) cores = 1 - if (cores > 4) cores = 4 - } - - c_r1 = params.clip_r1 > 0 ? "--clip_r1 ${params.clip_r1}" : '' - c_r2 = params.clip_r2 > 0 ? "--clip_r2 ${params.clip_r2}" : '' - tpc_r1 = params.three_prime_clip_r1 > 0 ? "--three_prime_clip_r1 ${params.three_prime_clip_r1}" : '' - tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' - nextseq = params.trim_nextseq > 0 ? "--nextseq ${params.trim_nextseq}" : '' - - // Added soft-links to original fastqs for consistent naming in MultiQC - if (single_end) { - """ - [ ! -f ${name}.fastq.gz ] && ln -s $reads ${name}.fastq.gz - trim_galore --cores $cores --fastqc --gzip $c_r1 $tpc_r1 $nextseq ${name}.fastq.gz - """ - } else { - """ - [ ! -f ${name}_1.fastq.gz ] && ln -s ${reads[0]} ${name}_1.fastq.gz - [ ! -f ${name}_2.fastq.gz ] && ln -s ${reads[1]} ${name}_2.fastq.gz - trim_galore --cores $cores --paired --fastqc --gzip $c_r1 $c_r2 $tpc_r1 $tpc_r2 $nextseq ${name}_1.fastq.gz ${name}_2.fastq.gz - """ - } -} From 208f0f2092580491fb6e0dcd96603722ed32bc36 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 20 Jul 2020 18:35:35 +0100 Subject: [PATCH 032/538] Add in file annotation --- main.nf | 24 +++++++++++------------- 1 file changed, 11 insertions(+), 13 deletions(-) diff --git a/main.nf b/main.nf index 41e134a5e..e2ba7bd51 100755 --- a/main.nf +++ b/main.nf @@ -204,7 +204,7 @@ workflow CHECK_INPUT { */ workflow QC_TRIM { take: - ch_reads // channel: [ val(metadata), [ reads ] ] + ch_reads // channel: [ val(meta), [ reads ] ] skip_fastqc // boolean: true/false skip_trimming // boolean: true/false fastqc_opts // map: options for FastQC module @@ -234,15 +234,15 @@ workflow QC_TRIM { } emit: - fastqc_html - fastqc_zip - fastqc_version + fastqc_html // channel: [ val(meta), [ html ] ] + fastqc_zip // channel: [ val(meta), [ zip ] ] + fastqc_version // path: *.version.txt - reads = ch_trim_reads - trim_html - trim_zip - trim_log - trim_version + reads = ch_trim_reads // channel: [ val(meta), [ reads ] ] + trim_html // channel: [ val(meta), [ html ] ] + trim_zip // channel: [ val(meta), [ zip ] ] + trim_log // channel: [ val(meta), [ txt ] ] + trim_version // path: *.version.txt } /* @@ -337,16 +337,14 @@ workflow { CHECK_INPUT(ch_input) // // PREPARE GENOME FILES - // if (!params.bwa_index) { BWA_INDEX(ch_fasta).set { ch_index } } + //if (!params.bwa_index) { BWA_INDEX(ch_fasta).set { ch_index } } // if (MakeBED) { GTF2BED(ch_gtf).set { ch_gene_bed } } // MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta).sizes, ch_blacklist.ifEmpty([])) - // + // READ QC & TRIMMING nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' params.modules['trim_galore'].args += nextseq QC_TRIM(CHECK_INPUT.out.reads, params.skip_fastqc, params.skip_trimming, params.modules['fastqc'], params.modules['trim_galore']) - - // // // MAP READS & BAM QC // ALIGN(QC_TRIM.out.reads, ch_index.collect()) // From b66ffb56bd22525c26d6170ae4a785dc9019a05c Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 20 Jul 2020 18:55:15 +0100 Subject: [PATCH 033/538] Add in bwa index --- conf/modules.config | 6 ++++++ main.nf | 2 +- modules/nf-core/bwa_index.nf | 25 +++++++++++++++++-------- modules/nf-core/fastqc.nf | 3 +-- modules/nf-core/trim_galore.nf | 3 +-- 5 files changed, 26 insertions(+), 13 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 3846281ce..78e9de36f 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -17,5 +17,11 @@ params { publish_dir = "trim_galore" publish_results = "all" } + 'bwa_index' { + args = "" + suffix = "" + publish_dir = "genome/bwa_index" + publish_results = "all" + } } } diff --git a/main.nf b/main.nf index e2ba7bd51..0a1081441 100755 --- a/main.nf +++ b/main.nf @@ -337,7 +337,7 @@ workflow { CHECK_INPUT(ch_input) // // PREPARE GENOME FILES - //if (!params.bwa_index) { BWA_INDEX(ch_fasta).set { ch_index } } + if (!params.bwa_index) { BWA_INDEX(ch_fasta, params.modules['bwa_index']).set { ch_index } } // if (MakeBED) { GTF2BED(ch_gtf).set { ch_gene_bed } } // MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta).sizes, ch_blacklist.ifEmpty([])) diff --git a/modules/nf-core/bwa_index.nf b/modules/nf-core/bwa_index.nf index 8f6e5f52e..ba8ecafe7 100644 --- a/modules/nf-core/bwa_index.nf +++ b/modules/nf-core/bwa_index.nf @@ -1,21 +1,30 @@ -/* - * Build BWA index - */ process BWA_INDEX { tag "$fasta" - //label 'process_high' - // publishDir path: { params.save_reference ? "${params.outdir}/genome" : params.outdir }, - // saveAs: { params.save_reference ? it : null }, mode: params.publish_dir_mode + label 'process_high' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "biocontainers/bwa:v0.7.17_cv1" + //container "https://depot.galaxyproject.org/singularity/bwa:0.7.17--hed695b0_7" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) input: path fasta + val opts output: - path 'BWAIndex' + path 'BWAIndex', emit: index + path "*.version.txt", emit: version script: """ - bwa index -a bwtsw $fasta + bwa index $opts.args -a bwtsw $fasta mkdir BWAIndex && mv ${fasta}* BWAIndex + echo \$(bwa 2>&1) | sed -n "s/.*\\(v.*\$\\)/\\1/p" > bwa.version.txt """ } diff --git a/modules/nf-core/fastqc.nf b/modules/nf-core/fastqc.nf index 46b5cff9e..7c8967e7f 100755 --- a/modules/nf-core/fastqc.nf +++ b/modules/nf-core/fastqc.nf @@ -1,5 +1,3 @@ -def MODULE = "fastqc" - process FASTQC { tag "$meta.id" label 'process_medium' @@ -7,6 +5,7 @@ process FASTQC { mode: params.publish_dir_mode, saveAs: { filename -> if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null else filename } container "quay.io/biocontainers/fastqc:0.11.9--0" diff --git a/modules/nf-core/trim_galore.nf b/modules/nf-core/trim_galore.nf index f8adc913c..4532d50bf 100644 --- a/modules/nf-core/trim_galore.nf +++ b/modules/nf-core/trim_galore.nf @@ -1,5 +1,3 @@ -def MODULE = "trim_galore" - process TRIM_GALORE { tag "$meta.id" label 'process_high' @@ -7,6 +5,7 @@ process TRIM_GALORE { mode: params.publish_dir_mode, saveAs: { filename -> if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null else filename } container "quay.io/biocontainers/trim-galore:0.6.5--0" From 99f53f4a2b067ada3a46bf447a27f23f173e7a9f Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 21 Jul 2020 09:54:33 +0100 Subject: [PATCH 034/538] Add gtf2bed --- bin/gtf2bed | 6 +++--- conf/modules.config | 6 ++++++ main.nf | 8 ++++---- modules/local/gtf2bed.nf | 17 ++++++++++++----- 4 files changed, 25 insertions(+), 12 deletions(-) diff --git a/bin/gtf2bed b/bin/gtf2bed index c2a8bbeee..e6904926d 100755 --- a/bin/gtf2bed +++ b/bin/gtf2bed @@ -1,4 +1,4 @@ -#!/usr/bin/perl +#!/usr/bin/env perl # Copyright (c) 2011 Erik Aronesty (erik@q32.com) # @@ -87,7 +87,7 @@ for $id ( my $beg = $ex[0][3]; my $end = $ex[-1][4]; - + if ($dir eq '-') { # swap $tmp=$cds; @@ -103,7 +103,7 @@ for $id ( # adjust start for bed --$beg; --$cds; - + my $exn = @ex; # exon count my $exst = join ",", map {$_->[3]-$beg-1} @ex; # exon start my $exsz = join ",", map {$_->[4]-$_->[3]+1} @ex; # exon size diff --git a/conf/modules.config b/conf/modules.config index 78e9de36f..1bb57c53b 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -23,5 +23,11 @@ params { publish_dir = "genome/bwa_index" publish_results = "all" } + 'gtf2bed' { + args = "" + suffix = "" + publish_dir = "genome" + publish_results = "all" + } } } diff --git a/main.nf b/main.nf index 0a1081441..3b2eb889a 100755 --- a/main.nf +++ b/main.nf @@ -82,12 +82,12 @@ if (params.anno_readme && file(params.anno_readme).exists()) { // If --gtf is supplied along with --genome // Make gene bed from supplied --gtf instead of using iGenomes one automatically -def MakeBED = false +def makeBED = false if (!params.gene_bed) { - MakeBED = true + makeBED = true } else if (params.genome && params.gtf) { if (params.genomes[ params.genome ].gtf != params.gtf) { - MakeBED = true + makeBED = true } } @@ -338,7 +338,7 @@ workflow { // // PREPARE GENOME FILES if (!params.bwa_index) { BWA_INDEX(ch_fasta, params.modules['bwa_index']).set { ch_index } } - // if (MakeBED) { GTF2BED(ch_gtf).set { ch_gene_bed } } + if (makeBED) { GTF2BED(ch_gtf, params.modules['gtf2bed']).set { ch_gene_bed } } // MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta).sizes, ch_blacklist.ifEmpty([])) // READ QC & TRIMMING diff --git a/modules/local/gtf2bed.nf b/modules/local/gtf2bed.nf index 304eb6b03..5a2426870 100644 --- a/modules/local/gtf2bed.nf +++ b/modules/local/gtf2bed.nf @@ -1,13 +1,20 @@ -/* - * Convert GTF to BED file - */ process GTF2BED { tag "$gtf" - //label 'process_low' - publishDir "${params.outdir}/genome", mode: params.publish_dir_mode + label 'process_low' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else filename } + + container "quay.io/biocontainers/perl:5.26.2" + //container "https://depot.galaxyproject.org/singularity/perl:5.26.2" + + //conda (params.conda ? "${moduleDir}/environment.yml" : null) input: path gtf + val opts output: path '*.bed' From 025375d4755566b09de587921b01188d0f403dcb Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 21 Jul 2020 10:21:00 +0100 Subject: [PATCH 035/538] Add genome filter processes --- conf/modules.config | 12 +++++++++ main.nf | 4 ++- modules/local/get_chrom_sizes.nf | 38 ++++++++++++++++++----------- modules/local/gtf2bed.nf | 3 +++ modules/local/make_genome_filter.nf | 15 +++++++++--- 5 files changed, 54 insertions(+), 18 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 1bb57c53b..e57bbf946 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -29,5 +29,17 @@ params { publish_dir = "genome" publish_results = "all" } + 'make_genome_filter' { + args = "" + suffix = "" + publish_dir = "genome" + publish_results = "all" + } + 'get_chrom_sizes' { + args = "" + suffix = "" + publish_dir = "genome" + publish_results = "all" + } } } diff --git a/main.nf b/main.nf index 3b2eb889a..1c91e7cf2 100755 --- a/main.nf +++ b/main.nf @@ -339,7 +339,9 @@ workflow { // // PREPARE GENOME FILES if (!params.bwa_index) { BWA_INDEX(ch_fasta, params.modules['bwa_index']).set { ch_index } } if (makeBED) { GTF2BED(ch_gtf, params.modules['gtf2bed']).set { ch_gene_bed } } - // MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta).sizes, ch_blacklist.ifEmpty([])) + MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta, params.modules['get_chrom_sizes']).sizes, + ch_blacklist.ifEmpty([]), + params.modules['make_genome_filter']) // READ QC & TRIMMING nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' diff --git a/modules/local/get_chrom_sizes.nf b/modules/local/get_chrom_sizes.nf index 9c9a35f86..79f6fa533 100644 --- a/modules/local/get_chrom_sizes.nf +++ b/modules/local/get_chrom_sizes.nf @@ -1,20 +1,30 @@ /* * Get chromosome sizes from a fasta file */ - process GET_CHROM_SIZES { - tag "$fasta" - publishDir "${params.outdir}/genome", mode: params.publish_dir_mode +process GET_CHROM_SIZES { + tag "$fasta" + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else filename } - input: - path fasta + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - output: - path '*.sizes', emit: sizes - path '*.fai', emit: fai + //conda (params.conda ? "${moduleDir}/environment.yml" : null) - script: - """ - samtools faidx $fasta - cut -f 1,2 ${fasta}.fai > ${fasta}.sizes - """ - } + input: + path fasta + val opts + + output: + path '*.sizes', emit: sizes + path '*.fai', emit: fai + + script: + """ + samtools faidx $fasta + cut -f 1,2 ${fasta}.fai > ${fasta}.sizes + """ +} diff --git a/modules/local/gtf2bed.nf b/modules/local/gtf2bed.nf index 5a2426870..44ee3b098 100644 --- a/modules/local/gtf2bed.nf +++ b/modules/local/gtf2bed.nf @@ -1,3 +1,6 @@ +/* + * Convert GTF file to BED format + */ process GTF2BED { tag "$gtf" label 'process_low' diff --git a/modules/local/make_genome_filter.nf b/modules/local/make_genome_filter.nf index 5e91d61ce..8b2943c75 100644 --- a/modules/local/make_genome_filter.nf +++ b/modules/local/make_genome_filter.nf @@ -1,14 +1,23 @@ /* - * Prepare genome intervals for filtering - * by removing regions in blacklist file + * Prepare genome intervals for filtering by removing regions in blacklist file */ process MAKE_GENOME_FILTER { tag "$sizes" - publishDir "${params.outdir}/genome", mode: params.publish_dir_mode + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else filename } + + container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" + //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" + + //conda (params.conda ? "${moduleDir}/environment.yml" : null) input: path sizes path blacklist + val opts output: path '*.bed' From f727441a425b9866b1418260eea1486ed29bb1ad Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 21 Jul 2020 12:09:22 +0100 Subject: [PATCH 036/538] Refactor mapping with bash expanded indices --- conf/modules.config | 9 +++- main.nf | 70 +++++++++++++++--------------- modules/local/check_samplesheet.nf | 8 +++- modules/nf-core/bwa_index.nf | 5 +-- modules/nf-core/bwa_mem.nf | 41 +++++++++-------- modules/nf-core/trim_galore.nf | 2 +- nextflow.config | 2 +- 7 files changed, 79 insertions(+), 58 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index e57bbf946..6262587ac 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -18,7 +18,7 @@ params { publish_results = "all" } 'bwa_index' { - args = "" + args = "-a bwtsw" suffix = "" publish_dir = "genome/bwa_index" publish_results = "all" @@ -41,5 +41,12 @@ params { publish_dir = "genome" publish_results = "all" } + 'bwa_mem' { + args = "-M" + args2 = "-h -F 0x0100 -O BAM" + suffix = ".Lb" + publish_dir = "bwa" + publish_results = "all" + } } } diff --git a/main.nf b/main.nf index 1c91e7cf2..8b2293a7b 100755 --- a/main.nf +++ b/main.nf @@ -58,22 +58,11 @@ if (params.gene_bed) { ch_gene_bed = file(params.gene_bed, checkIfExists: true) if (params.blacklist) { ch_blacklist = Channel.fromPath(params.blacklist, checkIfExists: true) } else { ch_blacklist = Channel.empty() } if (params.fasta) { - lastPath = params.fasta.lastIndexOf(File.separator) - params.bwa_base = params.fasta.substring(lastPath+1) ch_fasta = file(params.fasta, checkIfExists: true) } else { exit 1, 'Fasta file not specified!' } -if (params.bwa_index) { - lastPath = params.bwa_index.lastIndexOf(File.separator) - bwa_dir = params.bwa_index.substring(0,lastPath+1) - params.bwa_base = params.bwa_index.substring(lastPath+1) - Channel - .fromPath(bwa_dir, checkIfExists: true) - .set { ch_index } -} - // Save AWS IGenomes file containing annotation version if (params.anno_readme && file(params.anno_readme).exists()) { file("${params.outdir}/genome/").mkdirs() @@ -178,13 +167,14 @@ include { MULTIQC } from './modules/nf-core/multiqc' */ workflow CHECK_INPUT { take: - ch_input // file: /path/to/samplesheet.csv + ch_input // file: /path/to/samplesheet.csv + seq_center // string: sequencing center for read group main: CHECK_SAMPLESHEET(ch_input) .reads .splitCsv(header:true, sep:',') - .map { get_samplesheet_paths(it, params.single_end) } + .map { get_samplesheet_paths(it, params.single_end, seq_center) } .set { ch_reads } CHECK_SAMPLESHEET @@ -204,11 +194,11 @@ workflow CHECK_INPUT { */ workflow QC_TRIM { take: - ch_reads // channel: [ val(meta), [ reads ] ] - skip_fastqc // boolean: true/false - skip_trimming // boolean: true/false - fastqc_opts // map: options for FastQC module - trimgalore_opts // map: options for TrimGalore! module + ch_reads // channel: [ val(meta), [ reads ] ] + skip_fastqc // boolean: true/false + skip_trimming // boolean: true/false + fastqc_opts // map: options for FastQC module + trim_galore_opts // map: options for TrimGalore! module main: fastqc_html = Channel.empty() @@ -226,7 +216,7 @@ workflow QC_TRIM { trim_log = Channel.empty() trim_version = Channel.empty() if (!skip_trimming) { - TRIM_GALORE(ch_reads, trimgalore_opts).reads.set { ch_trim_reads } + TRIM_GALORE(ch_reads, trim_galore_opts).reads.set { ch_trim_reads } trim_html = TRIM_GALORE.out.html trim_zip = TRIM_GALORE.out.zip trim_log = TRIM_GALORE.out.log @@ -269,19 +259,23 @@ workflow SORT_BAM { */ workflow ALIGN { take: - ch_reads // channel: [ val(name), val(single_end), [ reads ] ] - ch_index // channel: [ /path/to/index ] + ch_reads // channel: [ val(meta), [ reads ] ] + ch_index // path: /path/to/index + ch_fasta // path: /path/to/genome.fasta + bwa_mem_opts // map: options for BWA MEM module main: - BWA_MEM(ch_reads, ch_index.collect()) - SORT_BAM(BWA_MEM.out) + BWA_MEM(ch_reads, ch_index, ch_fasta, bwa_mem_opts) + //SORT_BAM(BWA_MEM.out) emit: - bam = SORT_BAM.out.bam - bai = SORT_BAM.out.bai - stats = SORT_BAM.out.stats - flagstat = SORT_BAM.out.flagstat - idxstats = SORT_BAM.out.idxstats + bam = BWA_MEM.out.bam + // bam = SORT_BAM.out.bam + // bai = SORT_BAM.out.bai + // stats = SORT_BAM.out.stats + // flagstat = SORT_BAM.out.flagstat + // idxstats = SORT_BAM.out.idxstats + bwa_version = BWA_MEM.out.version } /* @@ -334,10 +328,10 @@ workflow FILTER_BAM { workflow { // READ IN SAMPLESHEET, VALIDATE AND STAGE INPUT FILES - CHECK_INPUT(ch_input) + CHECK_INPUT(ch_input, params.seq_center) - // // PREPARE GENOME FILES - if (!params.bwa_index) { BWA_INDEX(ch_fasta, params.modules['bwa_index']).set { ch_index } } + // PREPARE GENOME FILES + ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX(ch_fasta, params.modules['bwa_index']).index if (makeBED) { GTF2BED(ch_gtf, params.modules['gtf2bed']).set { ch_gene_bed } } MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta, params.modules['get_chrom_sizes']).sizes, ch_blacklist.ifEmpty([]), @@ -346,9 +340,17 @@ workflow { // READ QC & TRIMMING nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' params.modules['trim_galore'].args += nextseq - QC_TRIM(CHECK_INPUT.out.reads, params.skip_fastqc, params.skip_trimming, params.modules['fastqc'], params.modules['trim_galore']) - // // MAP READS & BAM QC - // ALIGN(QC_TRIM.out.reads, ch_index.collect()) + QC_TRIM(CHECK_INPUT.out.reads, + params.skip_fastqc, + params.skip_trimming, + params.modules['fastqc'], + params.modules['trim_galore']) + + // MAP READS & BAM QC + score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' + params.modules['bwa_mem'].args += score + ALIGN(QC_TRIM.out.reads, ch_index, ch_fasta, params.modules['bwa_mem']) + // // // MERGE RESEQUENCED BAM FILES // ALIGN diff --git a/modules/local/check_samplesheet.nf b/modules/local/check_samplesheet.nf index 97ceae3bb..24b08c2d8 100755 --- a/modules/local/check_samplesheet.nf +++ b/modules/local/check_samplesheet.nf @@ -19,11 +19,17 @@ process CHECK_SAMPLESHEET { } // Function to get list of [ meta, [ fastq_1, fastq_2 ] ] -def get_samplesheet_paths(LinkedHashMap row, boolean single_end) { +def get_samplesheet_paths(LinkedHashMap row, boolean single_end, String seq_center) { def meta = [:] meta.id = row.sample_id meta.single_end = single_end + def rg = "\'@RG\\tID:${meta.id}\\tSM:${meta.id.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${meta.id}\\tPU:1\'" + if (seq_center) { + rg = "\'@RG\\tID:${meta.id}\\tSM:${meta.id.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${meta.id}\\tPU:1\\tCN:${seq_center}\'" + } + meta.read_group = rg + def array = [] if (single_end) { array = [ meta, [ file(row.fastq_1, checkIfExists: true) ] ] diff --git a/modules/nf-core/bwa_index.nf b/modules/nf-core/bwa_index.nf index ba8ecafe7..545748120 100644 --- a/modules/nf-core/bwa_index.nf +++ b/modules/nf-core/bwa_index.nf @@ -18,13 +18,12 @@ process BWA_INDEX { val opts output: - path 'BWAIndex', emit: index + path "${fasta}.*", emit: index path "*.version.txt", emit: version script: """ - bwa index $opts.args -a bwtsw $fasta - mkdir BWAIndex && mv ${fasta}* BWAIndex + bwa index $opts.args $fasta echo \$(bwa 2>&1) | sed -n "s/.*\\(v.*\$\\)/\\1/p" > bwa.version.txt """ } diff --git a/modules/nf-core/bwa_mem.nf b/modules/nf-core/bwa_mem.nf index a0c72a81d..cc751edd9 100644 --- a/modules/nf-core/bwa_mem.nf +++ b/modules/nf-core/bwa_mem.nf @@ -1,32 +1,39 @@ -/* - * Map read(s) with bwa mem - */ process BWA_MEM { - tag "$name" + tag "$meta.id" label 'process_high' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" + //container "https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) input: - tuple val(name), val(single_end), path(reads) + tuple val(meta), path(reads) path index + path fasta + val opts output: - tuple val(name), val(single_end), path('*.bam') + tuple val(meta), path("*.bam"), emit: bam + path "*.version.txt", emit: version script: - prefix = "${name}.Lb" - rg = "\'@RG\\tID:${name}\\tSM:${name.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${name}\\tPU:1\'" - if (params.seq_center) { - rg = "\'@RG\\tID:${name}\\tSM:${name.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${name}\\tPU:1\\tCN:${params.seq_center}\'" - } - score = params.bwa_min_score ? "-T ${params.bwa_min_score}" : '' + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + rg = meta.read_group ? "-R ${meta.read_group}" : "" """ bwa mem \\ + $opts.args \\ + $rg \\ -t $task.cpus \\ - -M \\ - -R $rg \\ - $score \\ - ${index}/${params.bwa_base} \\ + $fasta \\ $reads \\ - | samtools view -@ $task.cpus -b -h -F 0x0100 -O BAM -o ${prefix}.bam - + | samtools view $opts.args2 -@ $task.cpus -bS -o ${prefix}.bam - + echo \$(bwa 2>&1) | sed -n "s/.*\\(v.*\$\\)/\\1/p" > bwa.version.txt """ } diff --git a/modules/nf-core/trim_galore.nf b/modules/nf-core/trim_galore.nf index 4532d50bf..a0fd544f7 100644 --- a/modules/nf-core/trim_galore.nf +++ b/modules/nf-core/trim_galore.nf @@ -43,7 +43,7 @@ process TRIM_GALORE { tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' // Added soft-links to original fastqs for consistent naming in MultiQC - prefix = opts.suffix ? "${meta.id}.${opts.suffix}" : "${meta.id}" + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" if (meta.single_end) { """ [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz diff --git a/nextflow.config b/nextflow.config index 7ff44b819..28e37f721 100644 --- a/nextflow.config +++ b/nextflow.config @@ -11,7 +11,7 @@ params { // Options: Generic input = './design.csv' single_end = false - seq_center = false + seq_center = '' fragment_size = 200 fingerprint_bins = 500000 From a036cb028bb4315589fa8528e0937ec9c568276b Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 21 Jul 2020 15:15:56 +0100 Subject: [PATCH 037/538] Finesse mapping and sorting steps --- conf/modules.config | 6 ++ main.nf | 82 ++++++++++++++++++--------- modules/nf-core/samtools_flagstat.nf | 28 +++++++++ modules/nf-core/samtools_flagstats.nf | 0 modules/nf-core/samtools_idxstats.nf | 28 +++++++++ modules/nf-core/samtools_index.nf | 25 +++++--- modules/nf-core/samtools_sort.nf | 29 +++++----- modules/nf-core/samtools_stats.nf | 32 ++++++----- 8 files changed, 165 insertions(+), 65 deletions(-) create mode 100644 modules/nf-core/samtools_flagstat.nf delete mode 100644 modules/nf-core/samtools_flagstats.nf diff --git a/conf/modules.config b/conf/modules.config index 6262587ac..dd225a141 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -48,5 +48,11 @@ params { publish_dir = "bwa" publish_results = "all" } + 'samtools_sort_lib' { + args = "" + suffix = ".Lb.sorted" + publish_dir = "bwa" + publish_results = "all" + } } } diff --git a/main.nf b/main.nf index 8b2293a7b..6f6808ea8 100755 --- a/main.nf +++ b/main.nf @@ -157,6 +157,8 @@ include { BWA_MEM } from './modules/nf-core/bwa_mem' include { SAMTOOLS_SORT } from './modules/nf-core/samtools_sort' include { SAMTOOLS_INDEX } from './modules/nf-core/samtools_index' include { SAMTOOLS_STATS } from './modules/nf-core/samtools_stats' +include { SAMTOOLS_IDXSTATS } from './modules/nf-core/samtools_idxstats' +include { SAMTOOLS_FLAGSTAT } from './modules/nf-core/samtools_flagstat' include { PICARD_MERGESAMFILES } from './modules/nf-core/picard_mergesamfiles' include { PICARD_MARKDUPLICATES } from './modules/nf-core/picard_markduplicates' //include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/picard_collectmultiplemetrics' @@ -185,8 +187,8 @@ workflow CHECK_INPUT { .set { ch_design } emit: - reads = ch_reads - design = ch_design + reads = ch_reads // channel: [ val(meta), [ reads ] ] + design = ch_design // channel: [ val(meta), [ reads ] ] } /* @@ -214,13 +216,13 @@ workflow QC_TRIM { trim_html = Channel.empty() trim_zip = Channel.empty() trim_log = Channel.empty() - trim_version = Channel.empty() + trim_galore_version = Channel.empty() if (!skip_trimming) { TRIM_GALORE(ch_reads, trim_galore_opts).reads.set { ch_trim_reads } trim_html = TRIM_GALORE.out.html trim_zip = TRIM_GALORE.out.zip trim_log = TRIM_GALORE.out.log - trim_version = TRIM_GALORE.out.version + trim_galore_version = TRIM_GALORE.out.version } emit: @@ -232,7 +234,27 @@ workflow QC_TRIM { trim_html // channel: [ val(meta), [ html ] ] trim_zip // channel: [ val(meta), [ zip ] ] trim_log // channel: [ val(meta), [ txt ] ] - trim_version // path: *.version.txt + trim_galore_version // path: *.version.txt +} + +/* + * Run SAMtools stats, flagstat and idxstats + */ +workflow BAM_STATS { + take: + ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] + samtools_opts // map: options for SAMTools modules + + main: + SAMTOOLS_STATS(ch_bam_bai, samtools_opts) + SAMTOOLS_FLAGSTAT(ch_bam_bai, samtools_opts) + SAMTOOLS_IDXSTATS(ch_bam_bai, samtools_opts) + + emit: + stats = SAMTOOLS_STATS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = SAMTOOLS_FLAGSTAT.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = SAMTOOLS_IDXSTATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + samtools_version = SAMTOOLS_STATS.out.version // path: *.version.txt } /* @@ -240,18 +262,21 @@ workflow QC_TRIM { */ workflow SORT_BAM { take: - ch_bam // channel: [ val(name), val(single_end), bam ] + ch_bam // channel: [ val(meta), [ bam ] ] + samtools_opts // map: options for SAMTools modules main: - SAMTOOLS_SORT(ch_bam) | SAMTOOLS_INDEX - SAMTOOLS_STATS(SAMTOOLS_SORT.out.join(SAMTOOLS_INDEX.out, by: [0,1])) + SAMTOOLS_SORT(ch_bam, samtools_opts) + SAMTOOLS_INDEX(SAMTOOLS_SORT.out.bam, samtools_opts) + BAM_STATS(SAMTOOLS_SORT.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_opts) emit: - bam = SAMTOOLS_SORT.out - bai = SAMTOOLS_INDEX.out - stats = SAMTOOLS_STATS.out.stats - flagstat = SAMTOOLS_STATS.out.flagstat - idxstats = SAMTOOLS_STATS.out.idxstats + bam = SAMTOOLS_SORT.out.bam // channel: [ val(meta), [ bam ] ] + bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_STATS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_STATS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_STATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + samtools_version = SAMTOOLS_SORT.out.version // path: *.version.txt } /* @@ -259,29 +284,30 @@ workflow SORT_BAM { */ workflow ALIGN { take: - ch_reads // channel: [ val(meta), [ reads ] ] - ch_index // path: /path/to/index - ch_fasta // path: /path/to/genome.fasta - bwa_mem_opts // map: options for BWA MEM module + ch_reads // channel: [ val(meta), [ reads ] ] + ch_index // path: /path/to/index + ch_fasta // path: /path/to/genome.fasta + bwa_mem_opts // map: options for BWA MEM module + samtools_opts // map: options for SAMTools modules main: BWA_MEM(ch_reads, ch_index, ch_fasta, bwa_mem_opts) - //SORT_BAM(BWA_MEM.out) + SORT_BAM(BWA_MEM.out.bam, samtools_opts) emit: - bam = BWA_MEM.out.bam - // bam = SORT_BAM.out.bam - // bai = SORT_BAM.out.bai - // stats = SORT_BAM.out.stats - // flagstat = SORT_BAM.out.flagstat - // idxstats = SORT_BAM.out.idxstats - bwa_version = BWA_MEM.out.version + bam = SORT_BAM.out.bam // channel: [ val(meta), [ bam ] ] + bai = SORT_BAM.out.bai // channel: [ val(meta), [ bai ] ] + stats = SORT_BAM.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = SORT_BAM.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = SORT_BAM.out.idxstats // channel: [ val(meta), [ idxstats ] ] + bwa_version = BWA_MEM.out.version // path: *.version.txt + samtools_version = SORT_BAM.out.samtools_version // path: *.version.txt } /* * Picard MarkDuplicates, sort, index BAM file and run samtools stats, flagstat and idxstats */ -workflow MARKDUP { +workflow MARKDUPLICATES { take: ch_bam // channel: [ val(name), val(single_end), bam ] @@ -349,7 +375,7 @@ workflow { // MAP READS & BAM QC score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' params.modules['bwa_mem'].args += score - ALIGN(QC_TRIM.out.reads, ch_index, ch_fasta, params.modules['bwa_mem']) + ALIGN(QC_TRIM.out.reads, ch_index, ch_fasta, params.modules['bwa_mem'], params.modules['samtools_sort_lib']) // // // MERGE RESEQUENCED BAM FILES @@ -363,7 +389,7 @@ workflow { // PICARD_MERGESAMFILES(ch_sort_bam) | MARKDUP // // // FILTER BAM FILES - // // FILTER_BAM(MARK_DUPS.out.bam, + // // FILTER_BAM(MARKDUPLICATES.out.bam, // // MAKE_GENOME_FILTER.out.collect(), // // ch_bamtools_filter_config) // Fix getting name sorted BAM here for PE/SE // diff --git a/modules/nf-core/samtools_flagstat.nf b/modules/nf-core/samtools_flagstat.nf new file mode 100644 index 000000000..eb5b910dc --- /dev/null +++ b/modules/nf-core/samtools_flagstat.nf @@ -0,0 +1,28 @@ +process SAMTOOLS_FLAGSTAT { + tag "$meta.id" + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) + + input: + tuple val(meta), path(bam), path(bai) + val opts + + output: + tuple val(meta), path("*.flagstat"), emit: flagstat + path "*.version.txt", emit: version + + script: + """ + samtools flagstat $bam > ${bam}.flagstat + samtools --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > samtools.version.txt + """ +} diff --git a/modules/nf-core/samtools_flagstats.nf b/modules/nf-core/samtools_flagstats.nf deleted file mode 100644 index e69de29bb..000000000 diff --git a/modules/nf-core/samtools_idxstats.nf b/modules/nf-core/samtools_idxstats.nf index e69de29bb..fd1eac27b 100644 --- a/modules/nf-core/samtools_idxstats.nf +++ b/modules/nf-core/samtools_idxstats.nf @@ -0,0 +1,28 @@ +process SAMTOOLS_IDXSTATS { + tag "$meta.id" + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) + + input: + tuple val(meta), path(bam), path(bai) + val opts + + output: + tuple val(meta), path("*.idxstats"), emit: idxstats + path "*.version.txt", emit: version + + script: + """ + samtools idxstats $bam > ${bam}.idxstats + samtools --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > samtools.version.txt + """ +} diff --git a/modules/nf-core/samtools_index.nf b/modules/nf-core/samtools_index.nf index a09bae039..204289fa8 100644 --- a/modules/nf-core/samtools_index.nf +++ b/modules/nf-core/samtools_index.nf @@ -1,19 +1,28 @@ -/* - * Index BAM file - */ process SAMTOOLS_INDEX { - tag "$name" - label 'process_medium' - publishDir path: "${params.outdir}", mode: params.publish_dir_mode + tag "$meta.id" + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) input: - tuple val(name), val(single_end), path(bam) + tuple val(meta), path(bam) + val opts output: - tuple val(name), val(single_end), path('*.bai') + tuple val(meta), path("*.bai"), emit: bai + path "*.version.txt", emit: version script: """ samtools index $bam + samtools --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > samtools.version.txt """ } diff --git a/modules/nf-core/samtools_sort.nf b/modules/nf-core/samtools_sort.nf index e61390762..c309a2af7 100644 --- a/modules/nf-core/samtools_sort.nf +++ b/modules/nf-core/samtools_sort.nf @@ -1,31 +1,30 @@ -def MODULE = "samtools_sort" -params.publish_dir = MODULE -params.publish_results = "default" -params.suffix = '' -//params.samtools_sort_args = '' - process SAMTOOLS_SORT { - publishDir "${params.outdir}/${params.publish_dir}", + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (params.publish_results == "none") null + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null else filename } - container "docker.pkg.github.com/nf-core/$MODULE" - conda "${moduleDir}/environment.yml" + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) input: - tuple val(name), val(single_end), path(bam) - //val (samtools_sort_args) + tuple val(meta), path(bam) + val opts output: - tuple val(name), val(single_end), path('*.bam') + tuple val(meta), path("*.bam"), emit: bam path "*.version.txt", emit: version script: - prefix = "${name}.${suffix}" + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" """ - samtools sort -@ $task.cpus -o ${prefix}.sorted.bam -T $name $bam + samtools sort $opts.args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam samtools --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > samtools.version.txt """ } diff --git a/modules/nf-core/samtools_stats.nf b/modules/nf-core/samtools_stats.nf index 1621bd141..c568740df 100644 --- a/modules/nf-core/samtools_stats.nf +++ b/modules/nf-core/samtools_stats.nf @@ -1,24 +1,28 @@ -/* - * Index BAM file - */ process SAMTOOLS_STATS { - tag "$name" - label 'process_medium' - publishDir path: "${params.outdir}", mode: params.publish_dir_mode + tag "$meta.id" + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) input: - tuple val(name), val(single_end), path(bam), path(bai) - + tuple val(meta), path(bam), path(bai) + val opts + output: - tuple val(name), val(single_end), path('*.stats'), emit: stats - tuple val(name), val(single_end), path('*.flagstat'), emit: flagstat - tuple val(name), val(single_end), path('*.idxstats'), emit: idxstats + tuple val(meta), path("*.stats"), emit: stats + path "*.version.txt", emit: version script: - prefix = "${name}.Lb" """ samtools stats $bam > ${bam}.stats - samtools flagstat $bam > ${bam}.flagstat - samtools idxstats $bam > ${bam}.idxstats + samtools --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > samtools.version.txt """ } From a9c391813fd7522faae6259d858e2abca1f15086 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 22 Jul 2020 00:16:50 +0100 Subject: [PATCH 038/538] Add in Picard MarkDuplicates --- conf/modules.config | 124 ++++++++++++++--------- main.nf | 50 +++++---- modules/nf-core/picard_markduplicates.nf | 41 +++++--- modules/nf-core/picard_mergesamfiles.nf | 39 ++++--- 4 files changed, 153 insertions(+), 101 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index dd225a141..01faeb553 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -4,55 +4,79 @@ * ------------------------------------------------- */ params { - modules { - 'fastqc' { - args = "--quiet" - suffix = "" - publish_dir = "fastqc" - publish_results = "all" + modules { + 'fastqc' { + args = "--quiet" + suffix = "" + publish_dir = "fastqc" + publish_results = "all" + } + 'trim_galore' { + args = "--fastqc" + suffix = "" + publish_dir = "trim_galore" + publish_results = "all" + } + 'bwa_index' { + args = "-a bwtsw" + suffix = "" + publish_dir = "genome/bwa_index" + publish_results = "all" + } + 'gtf2bed' { + args = "" + suffix = "" + publish_dir = "genome" + publish_results = "all" + } + 'make_genome_filter' { + args = "" + suffix = "" + publish_dir = "genome" + publish_results = "all" + } + 'get_chrom_sizes' { + args = "" + suffix = "" + publish_dir = "genome" + publish_results = "all" + } + 'bwa_mem' { + args = "-M" + args2 = "-h -F 0x0100 -O BAM" + suffix = ".Lb" + publish_dir = "bwa/library" + publish_results = "all" + } + 'samtools_sort_lib' { + args = "" + suffix = ".Lb.sorted" + publish_dir = "bwa/library" + publish_results = "all" + } + 'picard_mergesamfiles' { + args = "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" + suffix = ".mLb.sorted" + publish_dir = "bwa/mergedLibrary" + publish_results = "all" + } + 'picard_markduplicates' { + args = "ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" + suffix = ".mLb.mkD" + publish_dir = "bwa/mergedLibrary" + publish_results = "all" + } + 'samtools_sort_merged_lib' { + args = "" + suffix = ".mLb.mkD.sorted" + publish_dir = "bwa/mergedLibrary" + publish_results = "all" + } + 'picard_collectmultiplemetrics' { + args = "" + suffix = ".mLb.sorted" + publish_dir = "bwa/mergedLibrary/picard_metrics" + publish_results = "all" + } } - 'trim_galore' { - args = "--fastqc" - suffix = "" - publish_dir = "trim_galore" - publish_results = "all" - } - 'bwa_index' { - args = "-a bwtsw" - suffix = "" - publish_dir = "genome/bwa_index" - publish_results = "all" - } - 'gtf2bed' { - args = "" - suffix = "" - publish_dir = "genome" - publish_results = "all" - } - 'make_genome_filter' { - args = "" - suffix = "" - publish_dir = "genome" - publish_results = "all" - } - 'get_chrom_sizes' { - args = "" - suffix = "" - publish_dir = "genome" - publish_results = "all" - } - 'bwa_mem' { - args = "-M" - args2 = "-h -F 0x0100 -O BAM" - suffix = ".Lb" - publish_dir = "bwa" - publish_results = "all" - } - 'samtools_sort_lib' { - args = "" - suffix = ".Lb.sorted" - publish_dir = "bwa" - publish_results = "all" - } - } } diff --git a/main.nf b/main.nf index 6f6808ea8..ef72b1a1e 100755 --- a/main.nf +++ b/main.nf @@ -309,20 +309,24 @@ workflow ALIGN { */ workflow MARKDUPLICATES { take: - ch_bam // channel: [ val(name), val(single_end), bam ] + ch_bam // channel: [ val(meta), [ bam ] ] + markduplicates_opts // map: options for picard MarkDuplicates module + samtools_opts // map: options for SAMTools modules main: - PICARD_MARKDUPLICATES(ch_bam) - SAMTOOLS_INDEX(PICARD_MARKDUPLICATES.out.bam) - SAMTOOLS_STATS(PICARD_MARKDUPLICATES.out.bam.join(SAMTOOLS_INDEX.out, by: [0,1])) + PICARD_MARKDUPLICATES(ch_bam, markduplicates_opts) + SAMTOOLS_INDEX(PICARD_MARKDUPLICATES.out.bam, samtools_opts) + BAM_STATS(PICARD_MARKDUPLICATES.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_opts) emit: - bam = PICARD_MARKDUPLICATES.out.bam - metrics = PICARD_MARKDUPLICATES.out.metrics - bai = SAMTOOLS_INDEX.out - stats = SAMTOOLS_STATS.out.stats - flagstat = SAMTOOLS_STATS.out.flagstat - idxstats = SAMTOOLS_STATS.out.idxstats + bam = PICARD_MARKDUPLICATES.out.bam // channel: [ val(meta), [ bam ] ] + metrics = PICARD_MARKDUPLICATES.out.metrics // channel: [ val(meta), [ metrics ] ] + bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_STATS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_STATS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_STATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + picard_version = PICARD_MARKDUPLICATES.out.version // path: *.version.txt + samtools_version = SAMTOOLS_INDEX.out.version // path: *.version.txt } /* @@ -377,17 +381,21 @@ workflow { params.modules['bwa_mem'].args += score ALIGN(QC_TRIM.out.reads, ch_index, ch_fasta, params.modules['bwa_mem'], params.modules['samtools_sort_lib']) - // - // // MERGE RESEQUENCED BAM FILES - // ALIGN - // .out - // .bam - // .map { it -> [ it[0].split('_')[0..-2].join('_'), it[1], it[2] ] } - // .groupTuple(by: [0, 1]) - // .map { it -> [ it[0], it[1], it[2].flatten() ] } - // .set { ch_sort_bam } - // PICARD_MERGESAMFILES(ch_sort_bam) | MARKDUP - // + // MERGE RESEQUENCED BAM FILES + ALIGN + .out + .bam + .map { meta, bam -> + fmeta = meta.findAll { it.key != 'read_group' } + fmeta.id = fmeta.id.split('_')[0..-2].join('_') + [ fmeta, bam ] } + .groupTuple(by: [0]) + .map { it -> [ it[0], it[1].flatten() ] } + .set { ch_sort_bam } + + PICARD_MERGESAMFILES(ch_sort_bam, params.modules['picard_mergesamfiles']) + MARKDUPLICATES(PICARD_MERGESAMFILES.out.bam, params.modules['picard_markduplicates'], params.modules['samtools_sort_merged_lib']) + // // FILTER BAM FILES // // FILTER_BAM(MARKDUPLICATES.out.bam, // // MAKE_GENOME_FILTER.out.collect(), diff --git a/modules/nf-core/picard_markduplicates.nf b/modules/nf-core/picard_markduplicates.nf index 45e5c116b..785e4f769 100644 --- a/modules/nf-core/picard_markduplicates.nf +++ b/modules/nf-core/picard_markduplicates.nf @@ -1,20 +1,29 @@ -/* - * Picard MarkDuplicates - */ process PICARD_MARKDUPLICATES { - tag "$name" + tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/picard:2.23.2--0" + //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) input: - tuple val(name), val(single_end), path(bam) + tuple val(meta), path(bam) + val opts output: - tuple val(name), val(single_end), path("*.bam"), emit: bam - tuple val(name), val(single_end), path("*.txt"), emit: metrics + tuple val(meta), path("*.bam"), emit: bam + path "*.metrics.txt", emit: metrics + path "*.version.txt", emit: version script: - prefix = "${name}.mLb.mkD" + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" def avail_mem = 3 if (!task.memory) { log.info '[Picard MarkDuplicates] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' @@ -22,13 +31,13 @@ process PICARD_MARKDUPLICATES { avail_mem = task.memory.toGiga() } """ - picard -Xmx${avail_mem}g MarkDuplicates \\ + picard \\ + -Xmx${avail_mem}g \\ + MarkDuplicates \\ + $opts.args \\ INPUT=$bam \\ - OUTPUT=${prefix}.sorted.bam \\ - ASSUME_SORTED=true \\ - REMOVE_DUPLICATES=false \\ - METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt \\ - VALIDATION_STRINGENCY=LENIENT \\ - TMP_DIR=tmp + OUTPUT=${prefix}.bam \\ + METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt + picard MarkDuplicates --version &> picard.version.txt || true """ } diff --git a/modules/nf-core/picard_mergesamfiles.nf b/modules/nf-core/picard_mergesamfiles.nf index 785512d38..b732f7f6b 100644 --- a/modules/nf-core/picard_mergesamfiles.nf +++ b/modules/nf-core/picard_mergesamfiles.nf @@ -1,19 +1,28 @@ -/* - * Picard MergeSamFiles - */ process PICARD_MERGESAMFILES { - tag "$name" + tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/picard:2.23.2--0" + //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) input: - tuple val(name), val(single_end), path(bams) + tuple val(meta), path(bams) + val opts output: - tuple val(name), val(single_end), path("*.bam") + tuple val(meta), path("*.bam"), emit: bam + path "*.version.txt", emit: version script: - prefix = "${name}.mLb.mkD" + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" bam_files = bams.sort() def avail_mem = 3 if (!task.memory) { @@ -23,16 +32,18 @@ process PICARD_MERGESAMFILES { } if (bam_files.size() > 1) { """ - picard -Xmx${avail_mem}g MergeSamFiles \\ + picard \\ + -Xmx${avail_mem}g \\ + MergeSamFiles \\ + $opts.args \\ ${'INPUT='+bam_files.join(' INPUT=')} \\ - OUTPUT=${name}.sorted.bam \\ - SORT_ORDER=coordinate \\ - VALIDATION_STRINGENCY=LENIENT \\ - TMP_DIR=tmp + OUTPUT=${prefix}.bam + picard MergeSamFiles --version &> picard.version.txt || true """ } else { """ - ln -s ${bam_files[0]} ${name}.sorted.bam + ln -s ${bam_files[0]} ${prefix}.bam + picard MergeSamFiles --version &> picard.version.txt || true """ } } From 14d2bee6a1ddbe551bf94e8601fcded7e2ad2390 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 22 Jul 2020 01:06:29 +0100 Subject: [PATCH 039/538] Add in filter BAM steps --- conf/modules.config | 34 +++++- main.nf | 107 ++++++------------ modules/local/check_samplesheet.nf | 7 +- modules/local/filter_bam.nf | 33 +++--- modules/local/get_software_versions.nf | 12 +- modules/local/output_documentation.nf | 7 +- .../nf-core/picard_collectmultiplemetrics.nf | 44 +++++++ 7 files changed, 148 insertions(+), 96 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 01faeb553..2f21fabc3 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -5,6 +5,12 @@ */ params { modules { + 'check_samplesheet' { + args = "" + suffix = "" + publish_dir = "pipeline_info" + publish_results = "all" + } 'fastqc' { args = "--quiet" suffix = "" @@ -72,11 +78,35 @@ params { publish_dir = "bwa/mergedLibrary" publish_results = "all" } - 'picard_collectmultiplemetrics' { + 'filter_bam' { args = "" - suffix = ".mLb.sorted" + suffix = ".mLb.flT.sorted" + publish_dir = "bwa/mergedLibrary" + publish_results = "all" + } + 'samtools_sort_filter' { + args = "" + suffix = ".mLb.flT.sorted" + publish_dir = "bwa/mergedLibrary" + publish_results = "all" + } + 'picard_collectmultiplemetrics' { + args = "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" + suffix = ".mLb.mkD.sorted" publish_dir = "bwa/mergedLibrary/picard_metrics" publish_results = "all" } + 'get_software_versions' { + args = "" + suffix = "" + publish_dir = "pipeline_info" + publish_results = "all" + } + 'output_documentation' { + args = "" + suffix = "" + publish_dir = "pipeline_info" + publish_results = "all" + } } } diff --git a/main.nf b/main.nf index ef72b1a1e..a10f4baaa 100755 --- a/main.nf +++ b/main.nf @@ -161,7 +161,7 @@ include { SAMTOOLS_IDXSTATS } from './modules/nf-core/samtools_idxstats' include { SAMTOOLS_FLAGSTAT } from './modules/nf-core/samtools_flagstat' include { PICARD_MERGESAMFILES } from './modules/nf-core/picard_mergesamfiles' include { PICARD_MARKDUPLICATES } from './modules/nf-core/picard_markduplicates' -//include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/picard_collectmultiplemetrics' +include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/picard_collectmultiplemetrics' include { MULTIQC } from './modules/nf-core/multiqc' /* @@ -169,11 +169,12 @@ include { MULTIQC } from './modules/nf-core/multiqc' */ workflow CHECK_INPUT { take: - ch_input // file: /path/to/samplesheet.csv - seq_center // string: sequencing center for read group + ch_input // file: /path/to/samplesheet.csv + seq_center // string: sequencing center for read group + check_samplesheet_opts // map: options for TrimGalore! module main: - CHECK_SAMPLESHEET(ch_input) + CHECK_SAMPLESHEET(ch_input, check_samplesheet_opts) .reads .splitCsv(header:true, sep:',') .map { get_samplesheet_paths(it, params.single_end, seq_center) } @@ -332,33 +333,32 @@ workflow MARKDUPLICATES { /* * Filter BAM file */ -workflow FILTER_BAM { +workflow CLEAN_BAM { take: - ch_bam // channel: [ val(name), val(single_end), bam ] - ch_bai // channel: [ val(name), val(single_end), bai ] - ch_bed // channel: [ bed ] - config // file: BAMtools filter JSON config file + ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] + ch_bed // channel: [ bed ] + config // file: BAMtools filter JSON config file + filter_bam_opts // map: options for filter_bam module + samtools_opts // map: options for SAMTools modules main: - FILTER_BAM(ch_bam, - ch_bai, - ch_bed, - config) // Fix getting name sorted BAM here for PE/SE - SAMTOOLS_INDEX(FILTER_BAM.out.bam) - SAMTOOLS_STATS(FILTER_BAM.out.bam.join(SAMTOOLS_INDEX.out, by: [0,1])) + FILTER_BAM(ch_bam_bai, ch_bed, config, filter_bam_opts) + SAMTOOLS_INDEX(FILTER_BAM.out.bam, samtools_opts) + BAM_STATS(FILTER_BAM.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_opts) emit: - bam = FILTER_BAM.out.bam - bai = SAMTOOLS_INDEX.out - stats = SAMTOOLS_STATS.out.stats - flagstat = SAMTOOLS_STATS.out.flagstat - idxstats = SAMTOOLS_STATS.out.idxstats + bam = FILTER_BAM.out.bam // channel: [ val(meta), [ bam ] ] + bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_STATS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_STATS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_STATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + bamtools_version = FILTER_BAM.out.version // path: *.version.txt } workflow { // READ IN SAMPLESHEET, VALIDATE AND STAGE INPUT FILES - CHECK_INPUT(ch_input, params.seq_center) + CHECK_INPUT(ch_input, params.seq_center, params.modules['check_samplesheet']) // PREPARE GENOME FILES ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX(ch_fasta, params.modules['bwa_index']).index @@ -396,15 +396,20 @@ workflow { PICARD_MERGESAMFILES(ch_sort_bam, params.modules['picard_mergesamfiles']) MARKDUPLICATES(PICARD_MERGESAMFILES.out.bam, params.modules['picard_markduplicates'], params.modules['samtools_sort_merged_lib']) - // // FILTER BAM FILES - // // FILTER_BAM(MARKDUPLICATES.out.bam, - // // MAKE_GENOME_FILTER.out.collect(), - // // ch_bamtools_filter_config) // Fix getting name sorted BAM here for PE/SE - // - // // PIPELINE TEMPLATE REPORTING - // GET_SOFTWARE_VERSIONS() - // OUTPUT_DOCUMENTATION(ch_output_docs,ch_output_docs_images) - // + // FILTER BAM FILES + // Fix getting name sorted BAM here for PE/SE + CLEAN_BAM(MARKDUPLICATES.out.bam.join(MARKDUPLICATES.out.bai, by: [0]), + MAKE_GENOME_FILTER.out.collect(), + ch_bamtools_filter_config, + params.modules['filter_bam'], + params.modules['samtools_sort_filter']) + + //PICARD_COLLECTMULTIPLEMETRICS(MARKDUPLICATES.out.bam, ch_fasta, params.modules['picard_collectmultiplemetrics']) + + // PIPELINE TEMPLATE REPORTING + //GET_SOFTWARE_VERSIONS(params.modules['get_software_versions']) + //OUTPUT_DOCUMENTATION(ch_output_docs, ch_output_docs_images, params.modules['output_documentation']) + // // MULTIQC( // // summary, // // FASTQC.out, @@ -533,48 +538,6 @@ workflow.onComplete { // } // // /* -// * STEP 5.2: Picard CollectMultipleMetrics after merging libraries and filtering -// */ -// process PICARD_METRICS { -// tag "$name" -// label 'process_medium' -// publishDir path: "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (filename.endsWith('_metrics')) "picard_metrics/$filename" -// else if (filename.endsWith('.pdf')) "picard_metrics/pdf/$filename" -// else null -// } -// -// when: -// !params.skip_picard_metrics -// -// input: -// tuple val(name), path(bam) from ch_rm_orphan_bam_metrics -// path fasta from ch_fasta -// -// output: -// path '*_metrics' into ch_collectmetrics_mqc -// path '*.pdf' -// -// script: -// prefix = "${name}.mLb.clN" -// def avail_mem = 3 -// if (!task.memory) { -// log.info '[Picard CollectMultipleMetrics] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' -// } else { -// avail_mem = task.memory.toGiga() -// } -// """ -// picard -Xmx${avail_mem}g CollectMultipleMetrics \\ -// INPUT=${bam[0]} \\ -// OUTPUT=${prefix}.CollectMultipleMetrics \\ -// REFERENCE_SEQUENCE=$fasta \\ -// VALIDATION_STRINGENCY=LENIENT \\ -// TMP_DIR=tmp -// """ -// } -// -// /* // * STEP 5.3: Read depth normalised bigWig // */ // process BIGWIG { diff --git a/modules/local/check_samplesheet.nf b/modules/local/check_samplesheet.nf index 24b08c2d8..00184902a 100755 --- a/modules/local/check_samplesheet.nf +++ b/modules/local/check_samplesheet.nf @@ -3,10 +3,15 @@ */ process CHECK_SAMPLESHEET { tag "$samplesheet" - publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else filename } input: path samplesheet + val opts output: path 'samplesheet_reads.csv', emit: reads diff --git a/modules/local/filter_bam.nf b/modules/local/filter_bam.nf index 22b14cd12..330ee9c0e 100644 --- a/modules/local/filter_bam.nf +++ b/modules/local/filter_bam.nf @@ -2,33 +2,31 @@ * Filter BAM file */ process FILTER_BAM { - tag "$name" + tag "$meta.id" label 'process_medium' - publishDir path: "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode - // saveAs: { filename -> - // if (single_end || params.save_align_intermeds) { - // else if (filename.endsWith('.sorted.bam')) filename - // else if (filename.endsWith('.sorted.bam.bai')) filename - // else null - // } - // } + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } input: - tuple val(name), val(single_end), path(bam) - tuple val(name), val(single_end), path(bai) + tuple val(meta), path(bam), path(bai) path bed path config + val opts output: - tuple val(name), val(single_end), path('*.bam'), emit: bam - + tuple val(meta), path("*.bam"), emit: bam + path "*.version.txt", emit: version + script: - prefix = single_end ? "${name}.mLb.clN" : "${name}.mLb.flT" - filter_params = single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + filter_params = meta.single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' dup_params = params.keep_dups ? '' : '-F 0x0400' multimap_params = params.keep_multi_map ? '' : '-q 1' blacklist_params = params.blacklist ? "-L $bed" : '' - //name_sort_bam = single_end ? '' : "samtools sort -n -@ $task.cpus -o ${prefix}.bam -T $prefix ${prefix}.sorted.bam" """ samtools view \\ $filter_params \\ @@ -39,6 +37,9 @@ process FILTER_BAM { | bamtools filter \\ -out ${prefix}.sorted.bam \\ -script $config + echo \$(bamtools --version 2>&1) > bamtools.version.txt """ } +//prefix = meta.single_end ? "${name}.mLb.clN" : "${name}.mLb.flT" +//name_sort_bam = meta.single_end ? '' : "samtools sort -n -@ $task.cpus -o ${prefix}.bam -T $prefix ${prefix}.sorted.bam" //$name_sort_bam diff --git a/modules/local/get_software_versions.nf b/modules/local/get_software_versions.nf index 9d19a8758..0a90a0c62 100755 --- a/modules/local/get_software_versions.nf +++ b/modules/local/get_software_versions.nf @@ -2,11 +2,15 @@ * Parse software version numbers */ process GET_SOFTWARE_VERSIONS { - publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode, + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, saveAs: { filename -> - if (filename.indexOf(".csv") > 0) filename - else null - } + if (opts.publish_results == "none") null + else if (filename.endsWith('.yaml')) null + else filename } + + input: + val opts output: path 'software_versions_mqc.yaml' diff --git a/modules/local/output_documentation.nf b/modules/local/output_documentation.nf index b6d24b0f5..e3201527a 100755 --- a/modules/local/output_documentation.nf +++ b/modules/local/output_documentation.nf @@ -2,11 +2,16 @@ * Output Markdown documentation to HTML */ process OUTPUT_DOCUMENTATION { - publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else filename } input: path output_docs path images + val opts output: path "results_description.html" diff --git a/modules/nf-core/picard_collectmultiplemetrics.nf b/modules/nf-core/picard_collectmultiplemetrics.nf index e69de29bb..fa3304f7c 100644 --- a/modules/nf-core/picard_collectmultiplemetrics.nf +++ b/modules/nf-core/picard_collectmultiplemetrics.nf @@ -0,0 +1,44 @@ +process PICARD_COLLECTMULTIPLEMETRICS { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/picard:2.23.2--0" + //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) + + input: + tuple val(meta), path(bam) + path fasta + val opts + + output: + tuple val(meta), path("*_metrics"), emit: metrics + tuple val(meta), path("*.pdf"), emit: pdf + path "*.version.txt", emit: version + + script: + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + def avail_mem = 3 + if (!task.memory) { + log.info '[Picard CollectMultipleMetrics] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' + } else { + avail_mem = task.memory.toGiga() + } + """ + picard \\ + -Xmx${avail_mem}g \\ + CollectMultipleMetrics \\ + $opts.args \\ + INPUT=$bam \\ + OUTPUT=${prefix}.CollectMultipleMetrics \\ + REFERENCE_SEQUENCE=$fasta + picard CollectMultipleMetrics --version &> picard.version.txt || true + """ +} From 58bfb9db00889736684e148372b11e2d40401509 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 22 Jul 2020 12:18:07 +0100 Subject: [PATCH 040/538] Add in remove bam process --- conf/modules.config | 8 ++- main.nf | 102 +++++----------------------- modules/local/filter_bam.nf | 5 +- modules/local/remove_bam_orphans.nf | 32 +++++++++ 4 files changed, 58 insertions(+), 89 deletions(-) create mode 100644 modules/local/remove_bam_orphans.nf diff --git a/conf/modules.config b/conf/modules.config index 2f21fabc3..300da9b53 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -84,9 +84,15 @@ params { publish_dir = "bwa/mergedLibrary" publish_results = "all" } + 'remove_bam_orphans' { + args = "--only_fr_pairs" + suffix = ".mLb.clN" + publish_dir = "bwa/mergedLibrary" + publish_results = "all" + } 'samtools_sort_filter' { args = "" - suffix = ".mLb.flT.sorted" + suffix = ".mLb.clN.sorted" publish_dir = "bwa/mergedLibrary" publish_results = "all" } diff --git a/main.nf b/main.nf index a10f4baaa..564ebe66d 100755 --- a/main.nf +++ b/main.nf @@ -144,6 +144,7 @@ include { GTF2BED } from './modules/local/gtf2bed' include { GET_CHROM_SIZES } from './modules/local/get_chrom_sizes' include { MAKE_GENOME_FILTER } from './modules/local/make_genome_filter' include { FILTER_BAM } from './modules/local/filter_bam' +include { REMOVE_BAM_ORPHANS } from './modules/local/remove_bam_orphans' include { OUTPUT_DOCUMENTATION } from './modules/local/output_documentation' include { GET_SOFTWARE_VERSIONS } from './modules/local/get_software_versions' @@ -174,7 +175,7 @@ workflow CHECK_INPUT { check_samplesheet_opts // map: options for TrimGalore! module main: - CHECK_SAMPLESHEET(ch_input, check_samplesheet_opts) + CHECK_SAMPLESHEET (ch_input, check_samplesheet_opts) .reads .splitCsv(header:true, sep:',') .map { get_samplesheet_paths(it, params.single_end, seq_center) } @@ -335,23 +336,25 @@ workflow MARKDUPLICATES { */ workflow CLEAN_BAM { take: - ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] - ch_bed // channel: [ bed ] - config // file: BAMtools filter JSON config file - filter_bam_opts // map: options for filter_bam module - samtools_opts // map: options for SAMTools modules + ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] + ch_bed // channel: [ bed ] + config // file: BAMtools filter JSON config file + filter_bam_opts // map: options for filter_bam module + rm_bam_orphans_opts // map: options for remove_bam_orphans module + samtools_opts // map: options for SAMTools modules main: FILTER_BAM(ch_bam_bai, ch_bed, config, filter_bam_opts) - SAMTOOLS_INDEX(FILTER_BAM.out.bam, samtools_opts) - BAM_STATS(FILTER_BAM.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_opts) + REMOVE_BAM_ORPHANS(FILTER_BAM.out.bam, rm_bam_orphans_opts) + SORT_BAM(REMOVE_BAM_ORPHANS.out.bam, samtools_opts) emit: - bam = FILTER_BAM.out.bam // channel: [ val(meta), [ bam ] ] - bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] - stats = BAM_STATS.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = BAM_STATS.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = BAM_STATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + name_bam = REMOVE_BAM_ORPHANS.out.bam // channel: [ val(meta), [ bam ] ] + bam = SORT_BAM.out.bam // channel: [ val(meta), [ bam ] ] + bai = SORT_BAM.out.bai // channel: [ val(meta), [ bai ] ] + stats = SORT_BAM.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = SORT_BAM.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = SORT_BAM.out.idxstats // channel: [ val(meta), [ idxstats ] ] bamtools_version = FILTER_BAM.out.version // path: *.version.txt } @@ -402,9 +405,10 @@ workflow { MAKE_GENOME_FILTER.out.collect(), ch_bamtools_filter_config, params.modules['filter_bam'], + params.modules['remove_bam_orphans'], params.modules['samtools_sort_filter']) - //PICARD_COLLECTMULTIPLEMETRICS(MARKDUPLICATES.out.bam, ch_fasta, params.modules['picard_collectmultiplemetrics']) + //PICARD_COLLECTMULTIPLEMETRICS(CLEAN_BAM.out.bam, ch_fasta, params.modules['picard_collectmultiplemetrics']) // PIPELINE TEMPLATE REPORTING //GET_SOFTWARE_VERSIONS(params.modules['get_software_versions']) @@ -426,76 +430,6 @@ workflow.onComplete { Completion.summary(workflow, params, log) } -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// /* -- -- */ -// /* -- MERGE LIBRARY BAM -- */ -// /* -- -- */ -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// -// /* -// * STEP 4.3: Remove orphan reads from paired-end BAM file -// */ -// if (params.single_end) { -// ch_filter_bam -// .into { ch_rm_orphan_bam_metrics; -// ch_rm_orphan_bam_bigwig; -// ch_rm_orphan_bam_macs_1; -// ch_rm_orphan_bam_macs_2; -// ch_rm_orphan_bam_phantompeakqualtools; -// ch_rm_orphan_name_bam_counts } -// -// ch_filter_bam_flagstat -// .into { ch_rm_orphan_flagstat_bigwig; -// ch_rm_orphan_flagstat_macs; -// ch_rm_orphan_flagstat_mqc } -// -// ch_filter_bam_stats_mqc -// .set { ch_rm_orphan_stats_mqc } -// } else { -// process MERGED_BAM_REMOVE_ORPHAN { -// tag "$name" -// label 'process_medium' -// publishDir path: "${params.outdir}/bwa/mergedLibrary", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (filename.endsWith('.flagstat')) "samtools_stats/$filename" -// else if (filename.endsWith('.idxstats')) "samtools_stats/$filename" -// else if (filename.endsWith('.stats')) "samtools_stats/$filename" -// else if (filename.endsWith('.sorted.bam')) filename -// else if (filename.endsWith('.sorted.bam.bai')) filename -// else null -// } -// -// input: -// tuple val(name), path(bam) from ch_filter_bam -// -// output: -// tuple val(name), path('*.sorted.{bam,bam.bai}') into ch_rm_orphan_bam_metrics, -// ch_rm_orphan_bam_bigwig, -// ch_rm_orphan_bam_macs_1, -// ch_rm_orphan_bam_macs_2, -// ch_rm_orphan_bam_phantompeakqualtools -// tuple val(name), path("${prefix}.bam") into ch_rm_orphan_name_bam_counts -// tuple val(name), path('*.flagstat') into ch_rm_orphan_flagstat_bigwig, -// ch_rm_orphan_flagstat_macs, -// ch_rm_orphan_flagstat_mqc -// path '*.{idxstats,stats}' into ch_rm_orphan_stats_mqc -// -// script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ -// prefix = "${name}.mLb.clN" -// """ -// bampe_rm_orphan.py ${bam[0]} ${prefix}.bam --only_fr_pairs -// -// samtools sort -@ $task.cpus -o ${prefix}.sorted.bam -T $prefix ${prefix}.bam -// samtools index ${prefix}.sorted.bam -// samtools flagstat ${prefix}.sorted.bam > ${prefix}.sorted.bam.flagstat -// samtools idxstats ${prefix}.sorted.bam > ${prefix}.sorted.bam.idxstats -// samtools stats ${prefix}.sorted.bam > ${prefix}.sorted.bam.stats -// """ -// } -// } -// // /////////////////////////////////////////////////////////////////////////////// // /////////////////////////////////////////////////////////////////////////////// // /* -- -- */ diff --git a/modules/local/filter_bam.nf b/modules/local/filter_bam.nf index 330ee9c0e..32c9f8f02 100644 --- a/modules/local/filter_bam.nf +++ b/modules/local/filter_bam.nf @@ -35,11 +35,8 @@ process FILTER_BAM { $blacklist_params \\ -b $bam \\ | bamtools filter \\ - -out ${prefix}.sorted.bam \\ + -out ${prefix}.bam \\ -script $config echo \$(bamtools --version 2>&1) > bamtools.version.txt """ } -//prefix = meta.single_end ? "${name}.mLb.clN" : "${name}.mLb.flT" -//name_sort_bam = meta.single_end ? '' : "samtools sort -n -@ $task.cpus -o ${prefix}.bam -T $prefix ${prefix}.sorted.bam" -//$name_sort_bam diff --git a/modules/local/remove_bam_orphans.nf b/modules/local/remove_bam_orphans.nf new file mode 100644 index 000000000..46fbc30c9 --- /dev/null +++ b/modules/local/remove_bam_orphans.nf @@ -0,0 +1,32 @@ +/* + * Remove orphan reads from paired-end BAM file + */ +process REMOVE_BAM_ORPHANS { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else filename } + + input: + tuple val(meta), path(bam) + val opts + + output: + tuple val(meta), path("${prefix}.bam"), emit: bam + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + if (!meta.single_end) { + """ + samtools sort -n -@ $task.cpus -o ${prefix}.name.sorted.bam -T ${prefix}.name.sorted $bam + bampe_rm_orphan.py ${prefix}.name.sorted.bam ${prefix}.bam $opts.args + """ + } else { + """ + ln -s $bam ${prefix}.bam + """ + } +} From 55350953fb13072483c18d5df03c87cd15f5cf4a Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 22 Jul 2020 13:20:30 +0100 Subject: [PATCH 041/538] Add in preseq --- conf/modules.config | 12 ++++++++ main.nf | 47 ++++++++--------------------- modules/nf-core/multiqc.nf | 5 +++ modules/nf-core/preseq_lc_extrap.nf | 39 ++++++++++++++++++++++++ 4 files changed, 69 insertions(+), 34 deletions(-) create mode 100644 modules/nf-core/preseq_lc_extrap.nf diff --git a/conf/modules.config b/conf/modules.config index 300da9b53..db28c4b7f 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -102,6 +102,18 @@ params { publish_dir = "bwa/mergedLibrary/picard_metrics" publish_results = "all" } + 'preseq_lc_extrap' { + args = "-verbose -bam -seed 1" + suffix = ".mLb.mkD" + publish_dir = "bwa/mergedLibrary/preseq" + publish_results = "all" + } + 'bedtools_genomecov' { + args = "" + suffix = ".mLb.mkD" + publish_dir = "bwa/mergedLibrary/bigwig" + publish_results = "all" + } 'get_software_versions' { args = "" suffix = "" diff --git a/main.nf b/main.nf index 564ebe66d..bee390941 100755 --- a/main.nf +++ b/main.nf @@ -145,6 +145,7 @@ include { GET_CHROM_SIZES } from './modules/local/get_chrom_sizes' include { MAKE_GENOME_FILTER } from './modules/local/make_genome_filter' include { FILTER_BAM } from './modules/local/filter_bam' include { REMOVE_BAM_ORPHANS } from './modules/local/remove_bam_orphans' +include { BEDTOOLS_GENOMECOV } from './modules/local/bedtools_genomecov' include { OUTPUT_DOCUMENTATION } from './modules/local/output_documentation' include { GET_SOFTWARE_VERSIONS } from './modules/local/get_software_versions' @@ -163,6 +164,16 @@ include { SAMTOOLS_FLAGSTAT } from './modules/nf-core/samtools_flagstat' include { PICARD_MERGESAMFILES } from './modules/nf-core/picard_mergesamfiles' include { PICARD_MARKDUPLICATES } from './modules/nf-core/picard_markduplicates' include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/picard_collectmultiplemetrics' +include { PRESEQ_LC_EXTRAP } from './modules/nf-core/preseq_lc_extrap' +//include { UCSC_BEDRAPHTOBIGWIG } from './modules/nf-core/ucsc_bedgraphtobigwig' +//include { DEEPTOOLS_PLOTPROFILE } from './modules/nf-core/deeptools_plotprofile' +//include { DEEPTOOLS_PLOTHEATMAP } from './modules/nf-core/deeptools_plotheatmap' +//include { DEEPTOOLS_PLOTFINGERPRINT } from './modules/nf-core/deeptools_plotfingerprint' +//include { DEEPTOOLS_COMPUTEMATRIX } from './modules/nf-core/deeptools_computematrix' +//include { MACSC2_CALLPEAK } from './modules/nf-core/macs2_callpeak' +//include { HOMER_ANNOTATEPEAKS } from './modules/nf-core/homer_annotatepeaks' +//include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/phantompeakqualtools' +//include { SUBREAD_FEATURECOUNTS } from './modules/nf-core/subread_featurecounts' include { MULTIQC } from './modules/nf-core/multiqc' /* @@ -408,7 +419,8 @@ workflow { params.modules['remove_bam_orphans'], params.modules['samtools_sort_filter']) - //PICARD_COLLECTMULTIPLEMETRICS(CLEAN_BAM.out.bam, ch_fasta, params.modules['picard_collectmultiplemetrics']) + PICARD_COLLECTMULTIPLEMETRICS(CLEAN_BAM.out.bam, ch_fasta, params.modules['picard_collectmultiplemetrics']) + PRESEQ_LC_EXTRAP(CLEAN_BAM.out.bam, params.modules['preseq_lc_extrap']) // PIPELINE TEMPLATE REPORTING //GET_SOFTWARE_VERSIONS(params.modules['get_software_versions']) @@ -439,39 +451,6 @@ workflow.onComplete { // /////////////////////////////////////////////////////////////////////////////// // // /* -// * STEP 5.1: Preseq analysis after merging libraries and before filtering -// */ -// process PRESEQ { -// tag "$name" -// label 'process_medium' -// label 'error_ignore' -// publishDir "${params.outdir}/bwa/mergedLibrary/preseq", mode: params.publish_dir_mode -// -// when: -// !params.skip_preseq -// -// input: -// tuple val(name), path(bam) from ch_merge_bam_preseq -// -// output: -// path '*.ccurve.txt' into ch_preseq_mqc -// path '*.log' -// -// script: -// pe = params.single_end ? '' : '-pe' -// """ -// preseq lc_extrap \\ -// -output ${name}.ccurve.txt \\ -// -verbose \\ -// -bam \\ -// $pe \\ -// -seed 1 \\ -// ${bam[0]} -// cp .command.err ${name}.command.log -// """ -// } -// -// /* // * STEP 5.3: Read depth normalised bigWig // */ // process BIGWIG { diff --git a/modules/nf-core/multiqc.nf b/modules/nf-core/multiqc.nf index 5efb77a52..9181580d1 100755 --- a/modules/nf-core/multiqc.nf +++ b/modules/nf-core/multiqc.nf @@ -27,6 +27,11 @@ if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { process MULTIQC { publishDir "${params.outdir}/multiqc", mode: params.publish_dir_mode + container "quay.io/biocontainers/multiqc:1.9--pyh9f0ad1d_0" + //container "https://depot.galaxyproject.org/singularity/multiqc:1.9--pyh9f0ad1d_0" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) + input: path (multiqc_config) from ch_multiqc_config path (mqc_custom_config) from ch_multiqc_custom_config.collect().ifEmpty([]) diff --git a/modules/nf-core/preseq_lc_extrap.nf b/modules/nf-core/preseq_lc_extrap.nf new file mode 100644 index 000000000..b87a038be --- /dev/null +++ b/modules/nf-core/preseq_lc_extrap.nf @@ -0,0 +1,39 @@ +process PRESEQ_LC_EXTRAP { + tag "$meta.id" + label 'process_medium' + label 'error_ignore' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/preseq:2.0.3--hf53bd2b_3" + //container "https://depot.galaxyproject.org/singularity/preseq:2.0.3--hf53bd2b_3" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) + + input: + tuple val(meta), path(bam) + val opts + + output: + tuple val(meta), path("*.ccurve.txt"), emit: ccurve + tuple val(meta), path("*.log"), emit: log + path "*.version.txt", emit: version + + script: + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + pe = meta.single_end ? '' : '-pe' + """ + preseq \\ + lc_extrap \\ + $opts.args \\ + $pe \\ + -output ${prefix}.ccurve.txt \\ + $bam + cp .command.err ${prefix}.command.log + preseq &> preseq.version.txt + """ +} From 2e296db5a58c48f427d8e14126ee81e021d79423 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 22 Jul 2020 13:34:12 +0100 Subject: [PATCH 042/538] Add in BigWig generation --- conf/modules.config | 6 +++ main.nf | 46 +---------------------- modules/local/bedtools_genomecov.nf | 48 ++++++++++++++++++++++++ modules/nf-core/ucsc_bedgraphtobigwig.nf | 31 +++++++++++++++ 4 files changed, 87 insertions(+), 44 deletions(-) create mode 100644 modules/local/bedtools_genomecov.nf create mode 100644 modules/nf-core/ucsc_bedgraphtobigwig.nf diff --git a/conf/modules.config b/conf/modules.config index db28c4b7f..5cb9b2c36 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -114,6 +114,12 @@ params { publish_dir = "bwa/mergedLibrary/bigwig" publish_results = "all" } + 'ucsc_bedgraphtobigwig' { + args = "" + suffix = ".mLb.mkD" + publish_dir = "bwa/mergedLibrary/bigwig" + publish_results = "all" + } 'get_software_versions' { args = "" suffix = "" diff --git a/main.nf b/main.nf index bee390941..90bf7dccb 100755 --- a/main.nf +++ b/main.nf @@ -421,6 +421,8 @@ workflow { PICARD_COLLECTMULTIPLEMETRICS(CLEAN_BAM.out.bam, ch_fasta, params.modules['picard_collectmultiplemetrics']) PRESEQ_LC_EXTRAP(CLEAN_BAM.out.bam, params.modules['preseq_lc_extrap']) + BEDTOOLS_GENOMECOV(CLEAN_BAM.out.bam.join(CLEAN_BAM.out.flagstat, by: [0]), params.modules['bedtools_genomecov']) + UCSC_BEDRAPHTOBIGWIG(BEDTOOLS_GENOMECOV.out.bedgraph, GET_CHROM_SIZES.out.sizes, params.modules['ucsc_bedgraphtobigwig']) // PIPELINE TEMPLATE REPORTING //GET_SOFTWARE_VERSIONS(params.modules['get_software_versions']) @@ -442,50 +444,6 @@ workflow.onComplete { Completion.summary(workflow, params, log) } -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// /* -- -- */ -// /* -- MERGE LIBRARY BAM POST-ANALYSIS -- */ -// /* -- -- */ -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// -// /* -// * STEP 5.3: Read depth normalised bigWig -// */ -// process BIGWIG { -// tag "$name" -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/bigwig", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (filename.endsWith('scale_factor.txt')) "scale/$filename" -// else if (filename.endsWith('.bigWig')) filename -// else null -// } -// -// input: -// tuple val(name), path(bam), path(flagstat) from ch_rm_orphan_bam_bigwig.join(ch_rm_orphan_flagstat_bigwig, by: [0]) -// path sizes from ch_genome_sizes_bigwig.collect() -// -// output: -// tuple val(name), path('*.bigWig') into ch_bigwig_plotprofile -// path '*igv.txt' into ch_bigwig_igv -// path '*scale_factor.txt' -// -// script: -// pe_fragment = params.single_end ? '' : '-pc' -// extend = (params.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' -// """ -// SCALE_FACTOR=\$(grep 'mapped (' $flagstat | awk '{print 1000000/\$1}') -// echo \$SCALE_FACTOR > ${name}.scale_factor.txt -// genomeCoverageBed -ibam ${bam[0]} -bg -scale \$SCALE_FACTOR $pe_fragment $extend | sort -T '.' -k1,1 -k2,2n > ${name}.bedGraph -// -// bedGraphToBigWig ${name}.bedGraph $sizes ${name}.bigWig -// -// find * -type f -name "*.bigWig" -exec echo -e "bwa/mergedLibrary/bigwig/"{}"\\t0,0,178" \\; > ${name}.bigWig.igv.txt -// """ -// } -// // /* // * STEP 5.4: Generate gene body coverage plot with deepTools plotProfile and plotHeatmap // */ diff --git a/modules/local/bedtools_genomecov.nf b/modules/local/bedtools_genomecov.nf new file mode 100644 index 000000000..0a6dd7f99 --- /dev/null +++ b/modules/local/bedtools_genomecov.nf @@ -0,0 +1,48 @@ +process BEDTOOLS_GENOMECOV { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" + //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) + + input: + tuple val(meta), path(bam), path(flagstat) + val opts + + output: + tuple val(meta), path("*.bigWig"), emit: bigwig + tuple val(meta), path("*.txt"), emit: scale_factor + path "*.version.txt", emit: version + + script: + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + pe = meta.single_end ? '' : '-pc' + extend = (params.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' + """ + SCALE_FACTOR=\$(grep 'mapped (' $flagstat | awk '{print 1000000/\$1}') + echo \$SCALE_FACTOR > ${prefix}.scale_factor.txt + + bedtools \\ + genomecov \\ + -ibam $bam \\ + -bg \\ + -scale \$SCALE_FACTOR \\ + $pe \\ + $extend \\ + | sort -T '.' -k1,1 -k2,2n > ${prefix}.bedGraph + + bedtools --version > bedtools.version.txt + """ +} +// tuple val(name), path(bam), path(flagstat) from ch_rm_orphan_bam_bigwig.join(ch_rm_orphan_flagstat_bigwig, by: [0]) +// path sizes from ch_genome_sizes_bigwig.collect() +// bedGraphToBigWig ${prefix}.bedGraph $sizes ${prefix}.bigWig +//find * -type f -name "*.bigWig" -exec echo -e "bwa/mergedLibrary/bigwig/"{}"\\t0,0,178" \\; > ${name}.bigWig.igv.txt diff --git a/modules/nf-core/ucsc_bedgraphtobigwig.nf b/modules/nf-core/ucsc_bedgraphtobigwig.nf new file mode 100644 index 000000000..b9b2a20d9 --- /dev/null +++ b/modules/nf-core/ucsc_bedgraphtobigwig.nf @@ -0,0 +1,31 @@ +process UCSC_BEDRAPHTOBIGWIG { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/ucsc-bedgraphtobigwig:377--h446ed27_1" + //container "https://depot.galaxyproject.org/singularity/ucsc-bedgraphtobigwig:377--h446ed27_1" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) + + input: + tuple val(meta), path(bedgraph) + path sizes + val opts + + output: + tuple val(meta), path("*.bigWig"), emit: bigwig + path "*.version.txt", emit: version + + script: + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + """ + bedGraphToBigWig $bedgraph $sizes ${prefix}.bigWig + bedGraphToBigWig > ucsc.version.txt + """ +} From 82a1e3e2c8e81696845f03bbe26b3f9e620739e1 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 22 Jul 2020 14:31:31 +0100 Subject: [PATCH 043/538] Fix bigwig generation --- conf/modules.config | 18 ++++++++++++++++++ main.nf | 10 ++++++++-- modules/local/bedtools_genomecov.nf | 8 ++------ modules/nf-core/ucsc_bedgraphtobigwig.nf | 2 -- 4 files changed, 28 insertions(+), 10 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 5cb9b2c36..6ed67a1be 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -120,6 +120,24 @@ params { publish_dir = "bwa/mergedLibrary/bigwig" publish_results = "all" } + 'deeptools_computematrix' { + args = "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels" + suffix = ".mLb.mkD" + publish_dir = "bwa/mergedLibrary/deeptools" + publish_results = "all" + } + 'deeptools_plotprofile' { + args = "" + suffix = ".mLb.mkD" + publish_dir = "bwa/mergedLibrary/deeptools" + publish_results = "all" + } + 'deeptools_plotheatmap' { + args = "" + suffix = ".mLb.mkD" + publish_dir = "bwa/mergedLibrary/deeptools" + publish_results = "all" + } 'get_software_versions' { args = "" suffix = "" diff --git a/main.nf b/main.nf index 90bf7dccb..79098924d 100755 --- a/main.nf +++ b/main.nf @@ -165,11 +165,11 @@ include { PICARD_MERGESAMFILES } from './modules/nf-core/picard_mergesamfiles' include { PICARD_MARKDUPLICATES } from './modules/nf-core/picard_markduplicates' include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/picard_collectmultiplemetrics' include { PRESEQ_LC_EXTRAP } from './modules/nf-core/preseq_lc_extrap' -//include { UCSC_BEDRAPHTOBIGWIG } from './modules/nf-core/ucsc_bedgraphtobigwig' +include { UCSC_BEDRAPHTOBIGWIG } from './modules/nf-core/ucsc_bedgraphtobigwig' +include { DEEPTOOLS_COMPUTEMATRIX } from './modules/nf-core/deeptools_computematrix' //include { DEEPTOOLS_PLOTPROFILE } from './modules/nf-core/deeptools_plotprofile' //include { DEEPTOOLS_PLOTHEATMAP } from './modules/nf-core/deeptools_plotheatmap' //include { DEEPTOOLS_PLOTFINGERPRINT } from './modules/nf-core/deeptools_plotfingerprint' -//include { DEEPTOOLS_COMPUTEMATRIX } from './modules/nf-core/deeptools_computematrix' //include { MACSC2_CALLPEAK } from './modules/nf-core/macs2_callpeak' //include { HOMER_ANNOTATEPEAKS } from './modules/nf-core/homer_annotatepeaks' //include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/phantompeakqualtools' @@ -419,11 +419,17 @@ workflow { params.modules['remove_bam_orphans'], params.modules['samtools_sort_filter']) + // POST ALIGNMENT QC PICARD_COLLECTMULTIPLEMETRICS(CLEAN_BAM.out.bam, ch_fasta, params.modules['picard_collectmultiplemetrics']) PRESEQ_LC_EXTRAP(CLEAN_BAM.out.bam, params.modules['preseq_lc_extrap']) + + // COVERAGE TRACKS BEDTOOLS_GENOMECOV(CLEAN_BAM.out.bam.join(CLEAN_BAM.out.flagstat, by: [0]), params.modules['bedtools_genomecov']) UCSC_BEDRAPHTOBIGWIG(BEDTOOLS_GENOMECOV.out.bedgraph, GET_CHROM_SIZES.out.sizes, params.modules['ucsc_bedgraphtobigwig']) + // COVERATE PLOTS + //DEEPTOOLS_COMPUTEMATRIX(UCSC_BEDRAPHTOBIGWIG.out.bigwig, ch_gene_bed, params.modules['deeptools_computematrix']) + // PIPELINE TEMPLATE REPORTING //GET_SOFTWARE_VERSIONS(params.modules['get_software_versions']) //OUTPUT_DOCUMENTATION(ch_output_docs, ch_output_docs_images, params.modules['output_documentation']) diff --git a/modules/local/bedtools_genomecov.nf b/modules/local/bedtools_genomecov.nf index 0a6dd7f99..05611f55e 100644 --- a/modules/local/bedtools_genomecov.nf +++ b/modules/local/bedtools_genomecov.nf @@ -18,7 +18,7 @@ process BEDTOOLS_GENOMECOV { val opts output: - tuple val(meta), path("*.bigWig"), emit: bigwig + tuple val(meta), path("*.bedGraph"), emit: bedgraph tuple val(meta), path("*.txt"), emit: scale_factor path "*.version.txt", emit: version @@ -37,12 +37,8 @@ process BEDTOOLS_GENOMECOV { -scale \$SCALE_FACTOR \\ $pe \\ $extend \\ - | sort -T '.' -k1,1 -k2,2n > ${prefix}.bedGraph + | sort -T '.' -k1,1 -k2,2n > ${prefix}.bedGraph bedtools --version > bedtools.version.txt """ } -// tuple val(name), path(bam), path(flagstat) from ch_rm_orphan_bam_bigwig.join(ch_rm_orphan_flagstat_bigwig, by: [0]) -// path sizes from ch_genome_sizes_bigwig.collect() -// bedGraphToBigWig ${prefix}.bedGraph $sizes ${prefix}.bigWig -//find * -type f -name "*.bigWig" -exec echo -e "bwa/mergedLibrary/bigwig/"{}"\\t0,0,178" \\; > ${name}.bigWig.igv.txt diff --git a/modules/nf-core/ucsc_bedgraphtobigwig.nf b/modules/nf-core/ucsc_bedgraphtobigwig.nf index b9b2a20d9..7e93d36cc 100644 --- a/modules/nf-core/ucsc_bedgraphtobigwig.nf +++ b/modules/nf-core/ucsc_bedgraphtobigwig.nf @@ -20,12 +20,10 @@ process UCSC_BEDRAPHTOBIGWIG { output: tuple val(meta), path("*.bigWig"), emit: bigwig - path "*.version.txt", emit: version script: prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" """ bedGraphToBigWig $bedgraph $sizes ${prefix}.bigWig - bedGraphToBigWig > ucsc.version.txt """ } From 9432b6654a0ee9e89497b41d7e9dbdf023a236bf Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 22 Jul 2020 15:06:36 +0100 Subject: [PATCH 044/538] Add all deepTools processes --- conf/modules.config | 20 +++-- main.nf | 94 +++----------------- modules/nf-core/deeptools_computematrix.nf | 39 ++++++++ modules/nf-core/deeptools_plotfingerprint.nf | 41 +++++++++ modules/nf-core/deeptools_plotheatmap.nf | 36 ++++++++ modules/nf-core/deeptools_plotprofile.nf | 36 ++++++++ 6 files changed, 176 insertions(+), 90 deletions(-) create mode 100644 modules/nf-core/deeptools_computematrix.nf create mode 100644 modules/nf-core/deeptools_plotfingerprint.nf create mode 100644 modules/nf-core/deeptools_plotheatmap.nf create mode 100644 modules/nf-core/deeptools_plotprofile.nf diff --git a/conf/modules.config b/conf/modules.config index 6ed67a1be..195c2d964 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -98,43 +98,49 @@ params { } 'picard_collectmultiplemetrics' { args = "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" - suffix = ".mLb.mkD.sorted" + suffix = ".mLb.clN.sorted" publish_dir = "bwa/mergedLibrary/picard_metrics" publish_results = "all" } 'preseq_lc_extrap' { args = "-verbose -bam -seed 1" - suffix = ".mLb.mkD" + suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/preseq" publish_results = "all" } 'bedtools_genomecov' { args = "" - suffix = ".mLb.mkD" + suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/bigwig" publish_results = "all" } 'ucsc_bedgraphtobigwig' { args = "" - suffix = ".mLb.mkD" + suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/bigwig" publish_results = "all" } 'deeptools_computematrix' { args = "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels" - suffix = ".mLb.mkD" + suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/deeptools" publish_results = "all" } 'deeptools_plotprofile' { args = "" - suffix = ".mLb.mkD" + suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/deeptools" publish_results = "all" } 'deeptools_plotheatmap' { args = "" - suffix = ".mLb.mkD" + suffix = ".mLb.clN" + publish_dir = "bwa/mergedLibrary/deeptools" + publish_results = "all" + } + 'deeptools_plotfingerprint' { + args = "--skipZeros" + suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/deeptools" publish_results = "all" } diff --git a/main.nf b/main.nf index 79098924d..4d08988fd 100755 --- a/main.nf +++ b/main.nf @@ -167,9 +167,9 @@ include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/picard_collect include { PRESEQ_LC_EXTRAP } from './modules/nf-core/preseq_lc_extrap' include { UCSC_BEDRAPHTOBIGWIG } from './modules/nf-core/ucsc_bedgraphtobigwig' include { DEEPTOOLS_COMPUTEMATRIX } from './modules/nf-core/deeptools_computematrix' -//include { DEEPTOOLS_PLOTPROFILE } from './modules/nf-core/deeptools_plotprofile' -//include { DEEPTOOLS_PLOTHEATMAP } from './modules/nf-core/deeptools_plotheatmap' -//include { DEEPTOOLS_PLOTFINGERPRINT } from './modules/nf-core/deeptools_plotfingerprint' +include { DEEPTOOLS_PLOTPROFILE } from './modules/nf-core/deeptools_plotprofile' +include { DEEPTOOLS_PLOTHEATMAP } from './modules/nf-core/deeptools_plotheatmap' +include { DEEPTOOLS_PLOTFINGERPRINT } from './modules/nf-core/deeptools_plotfingerprint' //include { MACSC2_CALLPEAK } from './modules/nf-core/macs2_callpeak' //include { HOMER_ANNOTATEPEAKS } from './modules/nf-core/homer_annotatepeaks' //include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/phantompeakqualtools' @@ -421,14 +421,20 @@ workflow { // POST ALIGNMENT QC PICARD_COLLECTMULTIPLEMETRICS(CLEAN_BAM.out.bam, ch_fasta, params.modules['picard_collectmultiplemetrics']) - PRESEQ_LC_EXTRAP(CLEAN_BAM.out.bam, params.modules['preseq_lc_extrap']) + //PRESEQ_LC_EXTRAP(CLEAN_BAM.out.bam, params.modules['preseq_lc_extrap']) // COVERAGE TRACKS BEDTOOLS_GENOMECOV(CLEAN_BAM.out.bam.join(CLEAN_BAM.out.flagstat, by: [0]), params.modules['bedtools_genomecov']) UCSC_BEDRAPHTOBIGWIG(BEDTOOLS_GENOMECOV.out.bedgraph, GET_CHROM_SIZES.out.sizes, params.modules['ucsc_bedgraphtobigwig']) // COVERATE PLOTS - //DEEPTOOLS_COMPUTEMATRIX(UCSC_BEDRAPHTOBIGWIG.out.bigwig, ch_gene_bed, params.modules['deeptools_computematrix']) + DEEPTOOLS_COMPUTEMATRIX(UCSC_BEDRAPHTOBIGWIG.out.bigwig, ch_gene_bed, params.modules['deeptools_computematrix']) + DEEPTOOLS_PLOTPROFILE(DEEPTOOLS_COMPUTEMATRIX.out.matrix, params.modules['deeptools_plotprofile']) + DEEPTOOLS_PLOTHEATMAP(DEEPTOOLS_COMPUTEMATRIX.out.matrix, params.modules['deeptools_plotheatmap']) + + // Join control BAM here too to generate plots with IP and CONTROL together + params.modules['deeptools_plotfingerprint'].args += " --numberOfSamples $params.fingerprint_bins" + DEEPTOOLS_PLOTFINGERPRINT(CLEAN_BAM.out.bam.join(CLEAN_BAM.out.bai, by: [0]), params.modules['deeptools_plotfingerprint']) // PIPELINE TEMPLATE REPORTING //GET_SOFTWARE_VERSIONS(params.modules['get_software_versions']) @@ -449,49 +455,6 @@ workflow.onComplete { Completion.email(workflow, params, summary, run_name, baseDir, multiqc_report, log) Completion.summary(workflow, params, log) } - -// /* -// * STEP 5.4: Generate gene body coverage plot with deepTools plotProfile and plotHeatmap -// */ -// process PLOTPROFILE { -// tag "$name" -// label 'process_high' -// publishDir "${params.outdir}/bwa/mergedLibrary/deepTools/plotProfile", mode: params.publish_dir_mode -// -// when: -// !params.skip_plot_profile -// -// input: -// tuple val(name), path(bigwig) from ch_bigwig_plotprofile -// path bed from ch_gene_bed -// -// output: -// path '*.plotProfile.tab' into ch_plotprofile_mqc -// path '*.{gz,pdf,mat.tab}' -// -// script: -// """ -// computeMatrix scale-regions \\ -// --regionsFileName $bed \\ -// --scoreFileName $bigwig \\ -// --outFileName ${name}.computeMatrix.mat.gz \\ -// --outFileNameMatrix ${name}.computeMatrix.vals.mat.tab \\ -// --regionBodyLength 1000 \\ -// --beforeRegionStartLength 3000 \\ -// --afterRegionStartLength 3000 \\ -// --skipZeros \\ -// --smartLabels \\ -// --numberOfProcessors $task.cpus -// -// plotProfile --matrixFile ${name}.computeMatrix.mat.gz \\ -// --outFileName ${name}.plotProfile.pdf \\ -// --outFileNameData ${name}.plotProfile.tab -// -// plotHeatmap --matrixFile ${name}.computeMatrix.mat.gz \\ -// --outFileName ${name}.plotHeatmap.pdf \\ -// --outFileNameMatrix ${name}.plotHeatmap.mat.tab -// """ -// } // // /* // * STEP 5.5: Phantompeakqualtools @@ -550,41 +513,6 @@ workflow.onComplete { // ch_group_bam_counts } // // /* -// * STEP 6.1: deepTools plotFingerprint -// */ -// process PLOTFINGERPRINT { -// tag "${ip} vs ${control}" -// label 'process_high' -// publishDir "${params.outdir}/bwa/mergedLibrary/deepTools/plotFingerprint", mode: params.publish_dir_mode -// -// when: -// !params.skip_plot_fingerprint -// -// input: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), path(ipbam), val(control), path(controlbam), path(ipflagstat) from ch_group_bam_plotfingerprint -// -// output: -// path '*.raw.txt' into ch_plotfingerprint_mqc -// path '*.{txt,pdf}' -// -// script: -// extend = (params.single_end && params.fragment_size > 0) ? "--extendReads ${params.fragment_size}" : '' -// """ -// plotFingerprint \\ -// --bamfiles ${ipbam[0]} ${controlbam[0]} \\ -// --plotFile ${ip}.plotFingerprint.pdf \\ -// $extend \\ -// --labels $ip $control \\ -// --outRawCounts ${ip}.plotFingerprint.raw.txt \\ -// --outQualityMetrics ${ip}.plotFingerprint.qcmetrics.txt \\ -// --skipZeros \\ -// --JSDsample ${controlbam[0]} \\ -// --numberOfProcessors $task.cpus \\ -// --numberOfSamples $params.fingerprint_bins -// """ -// } -// -// /* // * STEP 6.2: Call peaks with MACS2 and calculate FRiP score // */ // process MACS2 { diff --git a/modules/nf-core/deeptools_computematrix.nf b/modules/nf-core/deeptools_computematrix.nf new file mode 100644 index 000000000..949c590f5 --- /dev/null +++ b/modules/nf-core/deeptools_computematrix.nf @@ -0,0 +1,39 @@ +process DEEPTOOLS_COMPUTEMATRIX { + tag "$meta.id" + label 'process_high' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/deeptools:3.4.3--py_0" + //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) + + input: + tuple val(meta), path(bigwig) + path bed + val opts + + output: + tuple val(meta), path("*.mat.gz"), emit: matrix + tuple val(meta), path("*.mat.tab"), emit: table + path "*.version.txt", emit: version + + script: + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + """ + computeMatrix \\ + $opts.args \\ + --regionsFileName $bed \\ + --scoreFileName $bigwig \\ + --outFileName ${prefix}.computeMatrix.mat.gz \\ + --outFileNameMatrix ${prefix}.computeMatrix.vals.mat.tab \\ + --numberOfProcessors $task.cpus + + echo \$(computeMatrix --version 2>&1) > deeptools.version.txt || true + """ +} diff --git a/modules/nf-core/deeptools_plotfingerprint.nf b/modules/nf-core/deeptools_plotfingerprint.nf new file mode 100644 index 000000000..99dbe26b9 --- /dev/null +++ b/modules/nf-core/deeptools_plotfingerprint.nf @@ -0,0 +1,41 @@ +process DEEPTOOLS_PLOTFINGERPRINT { + tag "$meta.id" + label 'process_high' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/deeptools:3.4.3--py_0" + //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) + + input: + tuple val(meta), path(bams), path(bais) + val opts + + output: + tuple val(meta), path("*.pdf"), emit: pdf + tuple val(meta), path("*.raw.txt"), emit: matrix + tuple val(meta), path("*.qcmetrics.txt"), emit: metrics + path "*.version.txt", emit: version + + script: + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + extend = (meta.single_end && params.fragment_size > 0) ? "--extendReads ${params.fragment_size}" : '' + """ + plotFingerprint \\ + $opts.args \\ + $extend \\ + --bamfiles ${bams.join(' ')} \\ + --plotFile ${prefix}.plotFingerprint.pdf \\ + --outRawCounts ${prefix}.plotFingerprint.raw.txt \\ + --outQualityMetrics ${prefix}.plotFingerprint.qcmetrics.txt \\ + --numberOfProcessors $task.cpus + + echo \$(plotFingerprint --version 2>&1) > deeptools.version.txt || true + """ +} diff --git a/modules/nf-core/deeptools_plotheatmap.nf b/modules/nf-core/deeptools_plotheatmap.nf new file mode 100644 index 000000000..bdc3f500c --- /dev/null +++ b/modules/nf-core/deeptools_plotheatmap.nf @@ -0,0 +1,36 @@ +process DEEPTOOLS_PLOTHEATMAP { + tag "$meta.id" + label 'process_low' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/deeptools:3.4.3--py_0" + //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) + + input: + tuple val(meta), path(matrix) + val opts + + output: + tuple val(meta), path("*.pdf"), emit: pdf + tuple val(meta), path("*.tab"), emit: table + path "*.version.txt", emit: version + + script: + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + """ + plotHeatmap \\ + $opts.args \\ + --matrixFile $matrix \\ + --outFileName ${prefix}.plotHeatmap.pdf \\ + --outFileNameMatrix ${prefix}.plotHeatmap.mat.tab + + echo \$(plotHeatmap --version 2>&1) > deeptools.version.txt || true + """ +} diff --git a/modules/nf-core/deeptools_plotprofile.nf b/modules/nf-core/deeptools_plotprofile.nf new file mode 100644 index 000000000..96db40318 --- /dev/null +++ b/modules/nf-core/deeptools_plotprofile.nf @@ -0,0 +1,36 @@ +process DEEPTOOLS_PLOTPROFILE { + tag "$meta.id" + label 'process_low' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/deeptools:3.4.3--py_0" + //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) + + input: + tuple val(meta), path(matrix) + val opts + + output: + tuple val(meta), path("*.pdf"), emit: pdf + tuple val(meta), path("*.tab"), emit: table + path "*.version.txt", emit: version + + script: + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + """ + plotProfile \\ + $opts.args \\ + --matrixFile $matrix \\ + --outFileName ${prefix}.plotProfile.pdf \\ + --outFileNameData ${prefix}.plotProfile.tab + + echo \$(plotProfile --version 2>&1) > deeptools.version.txt || true + """ +} From fd1c762b12b947653d5b4c6253af03b1fb7d3e9c Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 22 Jul 2020 15:45:10 +0100 Subject: [PATCH 045/538] Update modules config --- conf/modules.config | 6 ++++++ 1 file changed, 6 insertions(+) diff --git a/conf/modules.config b/conf/modules.config index 195c2d964..edc7ae554 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -144,6 +144,12 @@ params { publish_dir = "bwa/mergedLibrary/deeptools" publish_results = "all" } + 'homer_annotatepeaks_macs2' { + args = "-gid" + suffix = ".mLb.clN" + publish_dir = "bwa/mergedLibrary/homer" + publish_results = "all" + } 'get_software_versions' { args = "" suffix = "" From 7ffcd1c4984544f836d9ac7bf5afe0da5cbbdc64 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 22 Jul 2020 16:17:43 +0100 Subject: [PATCH 046/538] Add phantompeakqualtools --- conf/modules.config | 6 ++++ main.nf | 41 +++---------------------- modules/nf-core/phantompeakqualtools.nf | 34 ++++++++++++++++++++ 3 files changed, 45 insertions(+), 36 deletions(-) create mode 100644 modules/nf-core/phantompeakqualtools.nf diff --git a/conf/modules.config b/conf/modules.config index edc7ae554..fcb8eae3d 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -108,6 +108,12 @@ params { publish_dir = "bwa/mergedLibrary/preseq" publish_results = "all" } + 'phantompeakqualtools' { + args = "" + suffix = ".mLb.clN" + publish_dir = "bwa/mergedLibrary/phantompeakqualtools" + publish_results = "all" + } 'bedtools_genomecov' { args = "" suffix = ".mLb.clN" diff --git a/main.nf b/main.nf index 4d08988fd..653a00cd7 100755 --- a/main.nf +++ b/main.nf @@ -170,9 +170,9 @@ include { DEEPTOOLS_COMPUTEMATRIX } from './modules/nf-core/deeptools_computemat include { DEEPTOOLS_PLOTPROFILE } from './modules/nf-core/deeptools_plotprofile' include { DEEPTOOLS_PLOTHEATMAP } from './modules/nf-core/deeptools_plotheatmap' include { DEEPTOOLS_PLOTFINGERPRINT } from './modules/nf-core/deeptools_plotfingerprint' +include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/phantompeakqualtools' //include { MACSC2_CALLPEAK } from './modules/nf-core/macs2_callpeak' //include { HOMER_ANNOTATEPEAKS } from './modules/nf-core/homer_annotatepeaks' -//include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/phantompeakqualtools' //include { SUBREAD_FEATURECOUNTS } from './modules/nf-core/subread_featurecounts' include { MULTIQC } from './modules/nf-core/multiqc' @@ -422,6 +422,7 @@ workflow { // POST ALIGNMENT QC PICARD_COLLECTMULTIPLEMETRICS(CLEAN_BAM.out.bam, ch_fasta, params.modules['picard_collectmultiplemetrics']) //PRESEQ_LC_EXTRAP(CLEAN_BAM.out.bam, params.modules['preseq_lc_extrap']) + PHANTOMPEAKQUALTOOLS(CLEAN_BAM.out.bam, params.modules['phantompeakqualtools']) // COVERAGE TRACKS BEDTOOLS_GENOMECOV(CLEAN_BAM.out.bam.join(CLEAN_BAM.out.flagstat, by: [0]), params.modules['bedtools_genomecov']) @@ -436,6 +437,8 @@ workflow { params.modules['deeptools_plotfingerprint'].args += " --numberOfSamples $params.fingerprint_bins" DEEPTOOLS_PLOTFINGERPRINT(CLEAN_BAM.out.bam.join(CLEAN_BAM.out.bai, by: [0]), params.modules['deeptools_plotfingerprint']) + + // PIPELINE TEMPLATE REPORTING //GET_SOFTWARE_VERSIONS(params.modules['get_software_versions']) //OUTPUT_DOCUMENTATION(ch_output_docs, ch_output_docs_images, params.modules['output_documentation']) @@ -455,41 +458,7 @@ workflow.onComplete { Completion.email(workflow, params, summary, run_name, baseDir, multiqc_report, log) Completion.summary(workflow, params, log) } -// -// /* -// * STEP 5.5: Phantompeakqualtools -// */ -// process PHANTOMPEAKQUALTOOLS { -// tag "$name" -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/phantompeakqualtools", mode: params.publish_dir_mode -// -// when: -// !params.skip_spp -// -// input: -// tuple val(name), path(bam) from ch_rm_orphan_bam_phantompeakqualtools -// path spp_correlation_header from ch_spp_correlation_header -// path spp_nsc_header from ch_spp_nsc_header -// path spp_rsc_header from ch_spp_rsc_header -// -// output: -// path '*.spp.out' into ch_spp_out_mqc -// path '*_mqc.tsv' into ch_spp_csv_mqc -// path '*.pdf' -// -// script: -// """ -// RUN_SPP=`which run_spp.R` -// Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="${bam[0]}" -savp="${name}.spp.pdf" -savd="${name}.spp.Rdata" -out="${name}.spp.out" -p=$task.cpus -// cp $spp_correlation_header ${name}_spp_correlation_mqc.tsv -// Rscript -e "load('${name}.spp.Rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${name}_spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" -// -// awk -v OFS='\t' '{print "${name}", \$9}' ${name}.spp.out | cat $spp_nsc_header - > ${name}_spp_nsc_mqc.tsv -// awk -v OFS='\t' '{print "${name}", \$10}' ${name}.spp.out | cat $spp_rsc_header - > ${name}_spp_rsc_mqc.tsv -// """ -// } -// + // /////////////////////////////////////////////////////////////////////////////// // /////////////////////////////////////////////////////////////////////////////// // /* -- -- */ diff --git a/modules/nf-core/phantompeakqualtools.nf b/modules/nf-core/phantompeakqualtools.nf new file mode 100644 index 000000000..95b95ea97 --- /dev/null +++ b/modules/nf-core/phantompeakqualtools.nf @@ -0,0 +1,34 @@ +process PHANTOMPEAKQUALTOOLS { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/phantompeakqualtools:1.2.2--0" + //container "https://depot.galaxyproject.org/singularity/phantompeakqualtools:1.2.2--0" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) + + input: + tuple val(meta), path(bam) + val opts + + output: + tuple val(meta), path("*.out"), emit: spp + tuple val(meta), path("*.pdf"), emit: pdf + path "*.version.txt", emit: version + + script: + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + """ + RUN_SPP=`which run_spp.R` + Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus + Rscript -e "load('${prefix}.spp.Rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}_spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" + + touch phantompeakqualtools.version.txt + """ +} From 7385cc73042723d07126fb9aef84d60b1e6d4130 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 22 Jul 2020 16:26:18 +0100 Subject: [PATCH 047/538] Add last few nf-core/modules --- main.nf | 20 ++++++------ modules/nf-core/homer_annotatepeaks.nf | 40 ++++++++++++++++++++++++ modules/nf-core/macs2_callpeak.nf | 3 ++ modules/nf-core/multiqc.nf | 1 + modules/nf-core/subread_featurecounts.nf | 3 ++ 5 files changed, 56 insertions(+), 11 deletions(-) create mode 100644 modules/nf-core/homer_annotatepeaks.nf create mode 100644 modules/nf-core/macs2_callpeak.nf create mode 100644 modules/nf-core/subread_featurecounts.nf diff --git a/main.nf b/main.nf index 653a00cd7..f2e3d0b0a 100755 --- a/main.nf +++ b/main.nf @@ -437,17 +437,15 @@ workflow { params.modules['deeptools_plotfingerprint'].args += " --numberOfSamples $params.fingerprint_bins" DEEPTOOLS_PLOTFINGERPRINT(CLEAN_BAM.out.bam.join(CLEAN_BAM.out.bai, by: [0]), params.modules['deeptools_plotfingerprint']) - - - // PIPELINE TEMPLATE REPORTING - //GET_SOFTWARE_VERSIONS(params.modules['get_software_versions']) - //OUTPUT_DOCUMENTATION(ch_output_docs, ch_output_docs_images, params.modules['output_documentation']) - - // // MULTIQC( - // // summary, - // // FASTQC.out, - // // ch_multiqc_config - // // ) + // PIPELINE REPORTING + GET_SOFTWARE_VERSIONS(params.modules['get_software_versions']) + OUTPUT_DOCUMENTATION(ch_output_docs, ch_output_docs_images, params.modules['output_documentation']) + + // MULTIQC( + // summary, + // FASTQC.out, + // ch_multiqc_config + // ) } /* diff --git a/modules/nf-core/homer_annotatepeaks.nf b/modules/nf-core/homer_annotatepeaks.nf new file mode 100644 index 000000000..56189da48 --- /dev/null +++ b/modules/nf-core/homer_annotatepeaks.nf @@ -0,0 +1,40 @@ +process HOMER_ANNOTATEPEAKS { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/homer:4.11--pl526h9a982cc_2" + //container "https://depot.galaxyproject.org/singularity/homer:4.11--pl526h9a982cc_2" + + conda (params.conda ? "${moduleDir}/environment.yml" : null) + + input: + tuple val(meta), path(bed) + path fasta + path gtf + val opts + + output: + tuple val(meta), path("*.txt"), emit: txt + path "*.version.txt", emit: version + + script: + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + + """ + annotatePeaks.pl \\ + $opts.args \\ + $bed \\ + $fasta \\ + -gtf $gtf \\ + -cpu $task.cpus \\ + > ${prefix}.annotatePeaks.txt + + touch homer.version.txt + """ +} diff --git a/modules/nf-core/macs2_callpeak.nf b/modules/nf-core/macs2_callpeak.nf new file mode 100644 index 000000000..f65147b6f --- /dev/null +++ b/modules/nf-core/macs2_callpeak.nf @@ -0,0 +1,3 @@ +container "quay.io/biocontainers/macs2:2.2.7.1--py37h516909a_0" +//container "https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py37h516909a_0" +//echo \$(macs2 --version 2>&1) > macs2.version.txt diff --git a/modules/nf-core/multiqc.nf b/modules/nf-core/multiqc.nf index 9181580d1..08da39c29 100755 --- a/modules/nf-core/multiqc.nf +++ b/modules/nf-core/multiqc.nf @@ -52,5 +52,6 @@ process MULTIQC { // TODO nf-core: Specify which MultiQC modules to use with -m for a faster run time """ multiqc -f $rtitle $rfilename $custom_config_file . + multiqc --version > multiqc.version.txt """ } diff --git a/modules/nf-core/subread_featurecounts.nf b/modules/nf-core/subread_featurecounts.nf new file mode 100644 index 000000000..a27725fa1 --- /dev/null +++ b/modules/nf-core/subread_featurecounts.nf @@ -0,0 +1,3 @@ +container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" +//container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" +//echo \$(featureCounts -v 2>&1) > featurecounts.version.txt From 47d7ceabb29e7df0d41fa6caeba06833d767c852 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Thu, 23 Jul 2020 11:58:11 +0100 Subject: [PATCH 048/538] Restructure modules --- modules/nf-core/macs2_callpeak.nf | 3 - modules/nf-core/{ => software}/bwa_index.nf | 0 modules/nf-core/{ => software}/bwa_mem.nf | 0 .../{ => software}/deeptools_computematrix.nf | 0 .../deeptools_plotfingerprint.nf | 0 .../{ => software}/deeptools_plotheatmap.nf | 0 .../{ => software}/deeptools_plotprofile.nf | 0 modules/nf-core/{ => software}/fastqc.nf | 0 .../{ => software}/homer_annotatepeaks.nf | 0 modules/nf-core/software/macs2_callpeak.nf | 61 +++++++++++++++++++ modules/nf-core/{ => software}/multiqc.nf | 0 .../{ => software}/phantompeakqualtools.nf | 0 .../picard_collectmultiplemetrics.nf | 0 .../{ => software}/picard_markduplicates.nf | 0 .../{ => software}/picard_mergesamfiles.nf | 0 .../{ => software}/preseq_lc_extrap.nf | 0 .../{ => software}/samtools_flagstat.nf | 0 .../{ => software}/samtools_idxstats.nf | 0 .../nf-core/{ => software}/samtools_index.nf | 0 .../nf-core/{ => software}/samtools_sort.nf | 0 .../nf-core/{ => software}/samtools_stats.nf | 0 .../nf-core/software/subread_featurecounts.nf | 38 ++++++++++++ modules/nf-core/{ => software}/trim_galore.nf | 0 .../{ => software}/ucsc_bedgraphtobigwig.nf | 0 modules/nf-core/subread_featurecounts.nf | 3 - 25 files changed, 99 insertions(+), 6 deletions(-) delete mode 100644 modules/nf-core/macs2_callpeak.nf rename modules/nf-core/{ => software}/bwa_index.nf (100%) rename modules/nf-core/{ => software}/bwa_mem.nf (100%) rename modules/nf-core/{ => software}/deeptools_computematrix.nf (100%) rename modules/nf-core/{ => software}/deeptools_plotfingerprint.nf (100%) rename modules/nf-core/{ => software}/deeptools_plotheatmap.nf (100%) rename modules/nf-core/{ => software}/deeptools_plotprofile.nf (100%) rename modules/nf-core/{ => software}/fastqc.nf (100%) rename modules/nf-core/{ => software}/homer_annotatepeaks.nf (100%) create mode 100644 modules/nf-core/software/macs2_callpeak.nf rename modules/nf-core/{ => software}/multiqc.nf (100%) rename modules/nf-core/{ => software}/phantompeakqualtools.nf (100%) rename modules/nf-core/{ => software}/picard_collectmultiplemetrics.nf (100%) rename modules/nf-core/{ => software}/picard_markduplicates.nf (100%) rename modules/nf-core/{ => software}/picard_mergesamfiles.nf (100%) rename modules/nf-core/{ => software}/preseq_lc_extrap.nf (100%) rename modules/nf-core/{ => software}/samtools_flagstat.nf (100%) rename modules/nf-core/{ => software}/samtools_idxstats.nf (100%) rename modules/nf-core/{ => software}/samtools_index.nf (100%) rename modules/nf-core/{ => software}/samtools_sort.nf (100%) rename modules/nf-core/{ => software}/samtools_stats.nf (100%) create mode 100644 modules/nf-core/software/subread_featurecounts.nf rename modules/nf-core/{ => software}/trim_galore.nf (100%) rename modules/nf-core/{ => software}/ucsc_bedgraphtobigwig.nf (100%) delete mode 100644 modules/nf-core/subread_featurecounts.nf diff --git a/modules/nf-core/macs2_callpeak.nf b/modules/nf-core/macs2_callpeak.nf deleted file mode 100644 index f65147b6f..000000000 --- a/modules/nf-core/macs2_callpeak.nf +++ /dev/null @@ -1,3 +0,0 @@ -container "quay.io/biocontainers/macs2:2.2.7.1--py37h516909a_0" -//container "https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py37h516909a_0" -//echo \$(macs2 --version 2>&1) > macs2.version.txt diff --git a/modules/nf-core/bwa_index.nf b/modules/nf-core/software/bwa_index.nf similarity index 100% rename from modules/nf-core/bwa_index.nf rename to modules/nf-core/software/bwa_index.nf diff --git a/modules/nf-core/bwa_mem.nf b/modules/nf-core/software/bwa_mem.nf similarity index 100% rename from modules/nf-core/bwa_mem.nf rename to modules/nf-core/software/bwa_mem.nf diff --git a/modules/nf-core/deeptools_computematrix.nf b/modules/nf-core/software/deeptools_computematrix.nf similarity index 100% rename from modules/nf-core/deeptools_computematrix.nf rename to modules/nf-core/software/deeptools_computematrix.nf diff --git a/modules/nf-core/deeptools_plotfingerprint.nf b/modules/nf-core/software/deeptools_plotfingerprint.nf similarity index 100% rename from modules/nf-core/deeptools_plotfingerprint.nf rename to modules/nf-core/software/deeptools_plotfingerprint.nf diff --git a/modules/nf-core/deeptools_plotheatmap.nf b/modules/nf-core/software/deeptools_plotheatmap.nf similarity index 100% rename from modules/nf-core/deeptools_plotheatmap.nf rename to modules/nf-core/software/deeptools_plotheatmap.nf diff --git a/modules/nf-core/deeptools_plotprofile.nf b/modules/nf-core/software/deeptools_plotprofile.nf similarity index 100% rename from modules/nf-core/deeptools_plotprofile.nf rename to modules/nf-core/software/deeptools_plotprofile.nf diff --git a/modules/nf-core/fastqc.nf b/modules/nf-core/software/fastqc.nf similarity index 100% rename from modules/nf-core/fastqc.nf rename to modules/nf-core/software/fastqc.nf diff --git a/modules/nf-core/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf similarity index 100% rename from modules/nf-core/homer_annotatepeaks.nf rename to modules/nf-core/software/homer_annotatepeaks.nf diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf new file mode 100644 index 000000000..fa6e16d3e --- /dev/null +++ b/modules/nf-core/software/macs2_callpeak.nf @@ -0,0 +1,61 @@ +container "quay.io/biocontainers/macs2:2.2.7.1--py37h516909a_0" +//container "https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py37h516909a_0" +//echo \$(macs2 --version 2>&1) > macs2.version.txt + + +// /* +// * STEP 6.2: Call peaks with MACS2 and calculate FRiP score +// */ +// process MACS2 { +// tag "${ip} vs ${control}" +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (filename.endsWith('.tsv')) "qc/$filename" +// else if (filename.endsWith('.igv.txt')) null +// else filename +// } +// +// when: +// params.macs_gsize +// +// input: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), path(ipbam), val(control), path(controlbam), path(ipflagstat) from ch_group_bam_macs +// path peak_count_header from ch_peak_count_header +// path frip_score_header from ch_frip_score_header +// +// output: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), val(control), path("*.$PEAK_TYPE") into ch_macs_homer, +// ch_macs_qc, +// ch_macs_consensus +// path '*igv.txt' into ch_macs_igv +// path '*_mqc.tsv' into ch_macs_mqc +// path '*.{bed,xls,gappedPeak,bdg}' +// +// script: +// broad = params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}" +// format = params.single_end ? 'BAM' : 'BAMPE' +// pileup = params.save_macs_pileup ? '-B --SPMR' : '' +// fdr = params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '' +// pvalue = params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' +// """ +// macs2 callpeak \\ +// -t ${ipbam[0]} \\ +// -c ${controlbam[0]} \\ +// $broad \\ +// -f $format \\ +// -g $params.macs_gsize \\ +// -n $ip \\ +// $pileup \\ +// $fdr \\ +// $pvalue \\ +// --keep-dup all +// +// cat ${ip}_peaks.${PEAK_TYPE} | wc -l | awk -v OFS='\t' '{ print "${ip}", \$1 }' | cat $peak_count_header - > ${ip}_peaks.count_mqc.tsv +// +// READS_IN_PEAKS=\$(intersectBed -a ${ipbam[0]} -b ${ip}_peaks.${PEAK_TYPE} -bed -c -f 0.20 | awk -F '\t' '{sum += \$NF} END {print sum}') +// grep 'mapped (' $ipflagstat | awk -v a="\$READS_IN_PEAKS" -v OFS='\t' '{print "${ip}", a/\$1}' | cat $frip_score_header - > ${ip}_peaks.FRiP_mqc.tsv +// +// find * -type f -name "*.${PEAK_TYPE}" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/"{}"\\t0,0,178" \\; > ${ip}_peaks.igv.txt +// """ +// } diff --git a/modules/nf-core/multiqc.nf b/modules/nf-core/software/multiqc.nf similarity index 100% rename from modules/nf-core/multiqc.nf rename to modules/nf-core/software/multiqc.nf diff --git a/modules/nf-core/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf similarity index 100% rename from modules/nf-core/phantompeakqualtools.nf rename to modules/nf-core/software/phantompeakqualtools.nf diff --git a/modules/nf-core/picard_collectmultiplemetrics.nf b/modules/nf-core/software/picard_collectmultiplemetrics.nf similarity index 100% rename from modules/nf-core/picard_collectmultiplemetrics.nf rename to modules/nf-core/software/picard_collectmultiplemetrics.nf diff --git a/modules/nf-core/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf similarity index 100% rename from modules/nf-core/picard_markduplicates.nf rename to modules/nf-core/software/picard_markduplicates.nf diff --git a/modules/nf-core/picard_mergesamfiles.nf b/modules/nf-core/software/picard_mergesamfiles.nf similarity index 100% rename from modules/nf-core/picard_mergesamfiles.nf rename to modules/nf-core/software/picard_mergesamfiles.nf diff --git a/modules/nf-core/preseq_lc_extrap.nf b/modules/nf-core/software/preseq_lc_extrap.nf similarity index 100% rename from modules/nf-core/preseq_lc_extrap.nf rename to modules/nf-core/software/preseq_lc_extrap.nf diff --git a/modules/nf-core/samtools_flagstat.nf b/modules/nf-core/software/samtools_flagstat.nf similarity index 100% rename from modules/nf-core/samtools_flagstat.nf rename to modules/nf-core/software/samtools_flagstat.nf diff --git a/modules/nf-core/samtools_idxstats.nf b/modules/nf-core/software/samtools_idxstats.nf similarity index 100% rename from modules/nf-core/samtools_idxstats.nf rename to modules/nf-core/software/samtools_idxstats.nf diff --git a/modules/nf-core/samtools_index.nf b/modules/nf-core/software/samtools_index.nf similarity index 100% rename from modules/nf-core/samtools_index.nf rename to modules/nf-core/software/samtools_index.nf diff --git a/modules/nf-core/samtools_sort.nf b/modules/nf-core/software/samtools_sort.nf similarity index 100% rename from modules/nf-core/samtools_sort.nf rename to modules/nf-core/software/samtools_sort.nf diff --git a/modules/nf-core/samtools_stats.nf b/modules/nf-core/software/samtools_stats.nf similarity index 100% rename from modules/nf-core/samtools_stats.nf rename to modules/nf-core/software/samtools_stats.nf diff --git a/modules/nf-core/software/subread_featurecounts.nf b/modules/nf-core/software/subread_featurecounts.nf new file mode 100644 index 000000000..54771185a --- /dev/null +++ b/modules/nf-core/software/subread_featurecounts.nf @@ -0,0 +1,38 @@ +container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" +//container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" +//echo \$(featureCounts -v 2>&1) > featurecounts.version.txt + +// /* +// * STEP 7.3: Count reads in consensus peaks with featureCounts +// */ +// process CONSENSUS_PEAKS_COUNTS { +// tag "${antibody}" +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}", mode: params.publish_dir_mode +// +// when: +// params.macs_gsize && (replicatesExist || multipleGroups) && !params.skip_consensus_peaks +// +// input: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(bams), path(saf) from ch_group_bam_counts +// +// output: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), path('*featureCounts.txt') into ch_macs_consensus_counts +// path '*featureCounts.txt.summary' into ch_macs_consensus_counts_mqc +// +// script: +// prefix = "${antibody}.consensus_peaks" +// bam_files = bams.findAll { it.toString().endsWith('.bam') }.sort() +// pe_params = params.single_end ? '' : '-p --donotsort' +// """ +// featureCounts \\ +// -F SAF \\ +// -O \\ +// --fracOverlap 0.2 \\ +// -T $task.cpus \\ +// $pe_params \\ +// -a $saf \\ +// -o ${prefix}.featureCounts.txt \\ +// ${bam_files.join(' ')} +// """ +// } diff --git a/modules/nf-core/trim_galore.nf b/modules/nf-core/software/trim_galore.nf similarity index 100% rename from modules/nf-core/trim_galore.nf rename to modules/nf-core/software/trim_galore.nf diff --git a/modules/nf-core/ucsc_bedgraphtobigwig.nf b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf similarity index 100% rename from modules/nf-core/ucsc_bedgraphtobigwig.nf rename to modules/nf-core/software/ucsc_bedgraphtobigwig.nf diff --git a/modules/nf-core/subread_featurecounts.nf b/modules/nf-core/subread_featurecounts.nf deleted file mode 100644 index a27725fa1..000000000 --- a/modules/nf-core/subread_featurecounts.nf +++ /dev/null @@ -1,3 +0,0 @@ -container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" -//container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" -//echo \$(featureCounts -v 2>&1) > featurecounts.version.txt From 7e639f351aae4c616a5b292e20cb9025e48bd3da Mon Sep 17 00:00:00 2001 From: drpatelh Date: Thu, 23 Jul 2020 12:01:23 +0100 Subject: [PATCH 049/538] Restructure local modules --- .../local/{ => process}/bedtools_genomecov.nf | 0 modules/local/process/calc_frip.nf | 0 .../local/{ => process}/check_samplesheet.nf | 0 modules/local/process/featurecounts_deseq2.nf | 55 +++++++++++++++++++ modules/local/{ => process}/filter_bam.nf | 0 .../local/{ => process}/get_chrom_sizes.nf | 0 .../{ => process}/get_software_versions.nf | 0 modules/local/{ => process}/gtf2bed.nf | 0 modules/local/process/igv.nf | 25 +++++++++ modules/local/process/macs2_consensus.nf | 50 +++++++++++++++++ .../local/{ => process}/make_genome_filter.nf | 0 .../{ => process}/output_documentation.nf | 0 .../local/process/plot_homer_annotatepeaks.nf | 36 ++++++++++++ modules/local/process/plot_macs2_qc.nf | 36 ++++++++++++ .../local/{ => process}/remove_bam_orphans.nf | 0 15 files changed, 202 insertions(+) rename modules/local/{ => process}/bedtools_genomecov.nf (100%) create mode 100644 modules/local/process/calc_frip.nf rename modules/local/{ => process}/check_samplesheet.nf (100%) create mode 100644 modules/local/process/featurecounts_deseq2.nf rename modules/local/{ => process}/filter_bam.nf (100%) rename modules/local/{ => process}/get_chrom_sizes.nf (100%) rename modules/local/{ => process}/get_software_versions.nf (100%) rename modules/local/{ => process}/gtf2bed.nf (100%) create mode 100644 modules/local/process/igv.nf create mode 100644 modules/local/process/macs2_consensus.nf rename modules/local/{ => process}/make_genome_filter.nf (100%) rename modules/local/{ => process}/output_documentation.nf (100%) create mode 100644 modules/local/process/plot_homer_annotatepeaks.nf create mode 100644 modules/local/process/plot_macs2_qc.nf rename modules/local/{ => process}/remove_bam_orphans.nf (100%) diff --git a/modules/local/bedtools_genomecov.nf b/modules/local/process/bedtools_genomecov.nf similarity index 100% rename from modules/local/bedtools_genomecov.nf rename to modules/local/process/bedtools_genomecov.nf diff --git a/modules/local/process/calc_frip.nf b/modules/local/process/calc_frip.nf new file mode 100644 index 000000000..e69de29bb diff --git a/modules/local/check_samplesheet.nf b/modules/local/process/check_samplesheet.nf similarity index 100% rename from modules/local/check_samplesheet.nf rename to modules/local/process/check_samplesheet.nf diff --git a/modules/local/process/featurecounts_deseq2.nf b/modules/local/process/featurecounts_deseq2.nf new file mode 100644 index 000000000..fb1e28240 --- /dev/null +++ b/modules/local/process/featurecounts_deseq2.nf @@ -0,0 +1,55 @@ + + +// /* +// * STEP 7.4: Differential analysis with DESeq2 +// */ +// process CONSENSUS_PEAKS_DESEQ2 { +// tag "${antibody}" +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (filename.endsWith('.igv.txt')) null +// else filename +// } +// +// when: +// params.macs_gsize && replicatesExist && multipleGroups && !params.skip_consensus_peaks && !params.skip_diff_analysis +// +// input: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(counts) from ch_macs_consensus_counts +// path deseq2_pca_header from ch_deseq2_pca_header +// path deseq2_clustering_header from ch_deseq2_clustering_header +// +// output: +// path '*.tsv' into ch_macs_consensus_deseq_mqc +// path '*igv.txt' into ch_macs_consensus_deseq_comp_igv +// path '*.{RData,results.txt,pdf,log}' +// path 'sizeFactors' +// path '*vs*/*.{pdf,txt}' +// path '*vs*/*.bed' +// +// script: +// prefix = "${antibody}.consensus_peaks" +// bam_ext = params.single_end ? '.mLb.clN.sorted.bam' : '.mLb.clN.bam' +// vst = params.deseq2_vst ? '--vst TRUE' : '' +// """ +// featurecounts_deseq2.r \\ +// --featurecount_file $counts \\ +// --bam_suffix '$bam_ext' \\ +// --outdir ./ \\ +// --outprefix $prefix \\ +// --outsuffix '' \\ +// --cores $task.cpus \\ +// $vst +// +// sed 's/deseq2_pca/deseq2_pca_${task.index}/g' <$deseq2_pca_header >tmp.txt +// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt +// cat tmp.txt ${prefix}.pca.vals.txt > ${prefix}.pca.vals_mqc.tsv +// +// sed 's/deseq2_clustering/deseq2_clustering_${task.index}/g' <$deseq2_clustering_header >tmp.txt +// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt +// cat tmp.txt ${prefix}.sample.dists.txt > ${prefix}.sample.dists_mqc.tsv +// +// find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt +// """ +// } diff --git a/modules/local/filter_bam.nf b/modules/local/process/filter_bam.nf similarity index 100% rename from modules/local/filter_bam.nf rename to modules/local/process/filter_bam.nf diff --git a/modules/local/get_chrom_sizes.nf b/modules/local/process/get_chrom_sizes.nf similarity index 100% rename from modules/local/get_chrom_sizes.nf rename to modules/local/process/get_chrom_sizes.nf diff --git a/modules/local/get_software_versions.nf b/modules/local/process/get_software_versions.nf similarity index 100% rename from modules/local/get_software_versions.nf rename to modules/local/process/get_software_versions.nf diff --git a/modules/local/gtf2bed.nf b/modules/local/process/gtf2bed.nf similarity index 100% rename from modules/local/gtf2bed.nf rename to modules/local/process/gtf2bed.nf diff --git a/modules/local/process/igv.nf b/modules/local/process/igv.nf new file mode 100644 index 000000000..cc7a9c228 --- /dev/null +++ b/modules/local/process/igv.nf @@ -0,0 +1,25 @@ +// /* +// * STEP 8: Create IGV session file +// */ +// process IGV { +// publishDir "${params.outdir}/igv/${PEAK_TYPE}", mode: params.publish_dir_mode +// +// when: +// !params.skip_igv +// +// input: +// path fasta from ch_fasta +// path bigwigs from ch_bigwig_igv.collect().ifEmpty([]) +// path peaks from ch_macs_igv.collect().ifEmpty([]) +// path consensus_peaks from ch_macs_consensus_igv.collect().ifEmpty([]) +// path differential_peaks from ch_macs_consensus_deseq_comp_igv.collect().ifEmpty([]) +// +// output: +// path '*.{txt,xml}' +// +// script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ +// """ +// cat *.txt > igv_files.txt +// igv_files_to_session.py igv_session.xml igv_files.txt ../../genome/${fasta.getName()} --path_prefix '../../' +// """ +// } diff --git a/modules/local/process/macs2_consensus.nf b/modules/local/process/macs2_consensus.nf new file mode 100644 index 000000000..b36d6a197 --- /dev/null +++ b/modules/local/process/macs2_consensus.nf @@ -0,0 +1,50 @@ +// /* +// * STEP 7.1: Consensus peaks across samples, create boolean filtering file, SAF file for featureCounts and UpSetR plot for intersection +// */ +// process CONSENSUS_PEAKS { +// tag "${antibody}" +// label 'process_long' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (filename.endsWith('.igv.txt')) null +// else filename +// } +// +// when: +// params.macs_gsize && (replicatesExist || multipleGroups) && !params.skip_consensus_peaks +// +// input: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(peaks) from ch_macs_consensus +// +// output: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), path('*.bed') into ch_macs_consensus_bed +// tuple val(antibody), path('*.saf') into ch_macs_consensus_saf +// path '*.boolean.txt' into ch_macs_consensus_bool +// path '*igv.txt' into ch_macs_consensus_igv +// path '*.intersect.{txt,plot.pdf}' +// +// script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ +// prefix = "${antibody}.consensus_peaks" +// mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') +// collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') +// expandparam = params.narrow_peak ? '--is_narrow_peak' : '' +// """ +// sort -T '.' -k1,1 -k2,2n ${peaks.collect{it.toString()}.sort().join(' ')} \\ +// | mergeBed -c $mergecols -o $collapsecols > ${prefix}.txt +// +// macs2_merged_expand.py ${prefix}.txt \\ +// ${peaks.collect{it.toString()}.sort().join(',').replaceAll("_peaks.${PEAK_TYPE}","")} \\ +// ${prefix}.boolean.txt \\ +// --min_replicates $params.min_reps_consensus \\ +// $expandparam +// +// awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$1, \$2, \$3, \$4, "0", "+" }' ${prefix}.boolean.txt > ${prefix}.bed +// +// echo -e "GeneID\tChr\tStart\tEnd\tStrand" > ${prefix}.saf +// awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$4, \$1, \$2, \$3, "+" }' ${prefix}.boolean.txt >> ${prefix}.saf +// +// plot_peak_intersect.r -i ${prefix}.boolean.intersect.txt -o ${prefix}.boolean.intersect.plot.pdf +// +// find * -type f -name "${prefix}.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/"{}"\\t0,0,0" \\; > ${prefix}.bed.igv.txt +// """ +// } diff --git a/modules/local/make_genome_filter.nf b/modules/local/process/make_genome_filter.nf similarity index 100% rename from modules/local/make_genome_filter.nf rename to modules/local/process/make_genome_filter.nf diff --git a/modules/local/output_documentation.nf b/modules/local/process/output_documentation.nf similarity index 100% rename from modules/local/output_documentation.nf rename to modules/local/process/output_documentation.nf diff --git a/modules/local/process/plot_homer_annotatepeaks.nf b/modules/local/process/plot_homer_annotatepeaks.nf new file mode 100644 index 000000000..477c84845 --- /dev/null +++ b/modules/local/process/plot_homer_annotatepeaks.nf @@ -0,0 +1,36 @@ +// /* +// * STEP 6.4: Aggregated QC plots for peaks, FRiP and peak-to-gene annotation +// */ +// process MACS2_QC { +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/qc", mode: params.publish_dir_mode +// +// when: +// params.macs_gsize && !params.skip_peak_annotation && !params.skip_peak_qc +// +// input: +// path peaks from ch_macs_qc.collect{ it[-1] } +// path annos from ch_macs_annotate.collect() +// path peak_annotation_header from ch_peak_annotation_header +// +// output: +// path '*.tsv' into ch_macs_qc_mqc +// path '*.{txt,pdf}' +// +// script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ +// """ +// plot_macs_qc.r \\ +// -i ${peaks.join(',')} \\ +// -s ${peaks.join(',').replaceAll("_peaks.${PEAK_TYPE}","")} \\ +// -o ./ \\ +// -p macs_peak +// +// plot_homer_annotatepeaks.r \\ +// -i ${annos.join(',')} \\ +// -s ${annos.join(',').replaceAll("_peaks.annotatePeaks.txt","")} \\ +// -o ./ \\ +// -p macs_annotatePeaks +// +// cat $peak_annotation_header macs_annotatePeaks.summary.txt > macs_annotatePeaks.summary_mqc.tsv +// """ +// } diff --git a/modules/local/process/plot_macs2_qc.nf b/modules/local/process/plot_macs2_qc.nf new file mode 100644 index 000000000..477c84845 --- /dev/null +++ b/modules/local/process/plot_macs2_qc.nf @@ -0,0 +1,36 @@ +// /* +// * STEP 6.4: Aggregated QC plots for peaks, FRiP and peak-to-gene annotation +// */ +// process MACS2_QC { +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/qc", mode: params.publish_dir_mode +// +// when: +// params.macs_gsize && !params.skip_peak_annotation && !params.skip_peak_qc +// +// input: +// path peaks from ch_macs_qc.collect{ it[-1] } +// path annos from ch_macs_annotate.collect() +// path peak_annotation_header from ch_peak_annotation_header +// +// output: +// path '*.tsv' into ch_macs_qc_mqc +// path '*.{txt,pdf}' +// +// script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ +// """ +// plot_macs_qc.r \\ +// -i ${peaks.join(',')} \\ +// -s ${peaks.join(',').replaceAll("_peaks.${PEAK_TYPE}","")} \\ +// -o ./ \\ +// -p macs_peak +// +// plot_homer_annotatepeaks.r \\ +// -i ${annos.join(',')} \\ +// -s ${annos.join(',').replaceAll("_peaks.annotatePeaks.txt","")} \\ +// -o ./ \\ +// -p macs_annotatePeaks +// +// cat $peak_annotation_header macs_annotatePeaks.summary.txt > macs_annotatePeaks.summary_mqc.tsv +// """ +// } diff --git a/modules/local/remove_bam_orphans.nf b/modules/local/process/remove_bam_orphans.nf similarity index 100% rename from modules/local/remove_bam_orphans.nf rename to modules/local/process/remove_bam_orphans.nf From 7bd0e6b0e619754845e2f65bb4641671bba42bdf Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 24 Jul 2020 09:21:38 +0100 Subject: [PATCH 050/538] Add subworkflow dirs --- modules/local/subworkflow/check_input.nf | 0 modules/nf-core/subworkflow/preprocess.nf | 0 2 files changed, 0 insertions(+), 0 deletions(-) create mode 100644 modules/local/subworkflow/check_input.nf create mode 100644 modules/nf-core/subworkflow/preprocess.nf diff --git a/modules/local/subworkflow/check_input.nf b/modules/local/subworkflow/check_input.nf new file mode 100644 index 000000000..e69de29bb diff --git a/modules/nf-core/subworkflow/preprocess.nf b/modules/nf-core/subworkflow/preprocess.nf new file mode 100644 index 000000000..e69de29bb From 61cf6f5bfce3b3c7705572d742582adc04cde854 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 24 Jul 2020 11:58:22 +0100 Subject: [PATCH 051/538] Reorganise everything --- conf/modules.config | 4 +- main.nf | 483 +++++++----------- modules/local/subworkflow/check_input.nf | 32 ++ modules/local/subworkflow/clean_bam.nf | 31 ++ ...preseq_lc_extrap.nf => preseq_lcextrap.nf} | 2 +- .../{trim_galore.nf => trimgalore.nf} | 2 +- modules/nf-core/subworkflow/bam_stats.nf | 24 + modules/nf-core/subworkflow/map_reads.nf | 28 + .../nf-core/subworkflow/mark_duplicates.nf | 29 ++ modules/nf-core/subworkflow/preprocess.nf | 0 modules/nf-core/subworkflow/qc_trim.nf | 49 ++ modules/nf-core/subworkflow/sort_bam.nf | 26 + 12 files changed, 417 insertions(+), 293 deletions(-) create mode 100644 modules/local/subworkflow/clean_bam.nf rename modules/nf-core/software/{preseq_lc_extrap.nf => preseq_lcextrap.nf} (94%) rename modules/nf-core/software/{trim_galore.nf => trimgalore.nf} (96%) create mode 100644 modules/nf-core/subworkflow/bam_stats.nf create mode 100644 modules/nf-core/subworkflow/map_reads.nf create mode 100644 modules/nf-core/subworkflow/mark_duplicates.nf delete mode 100644 modules/nf-core/subworkflow/preprocess.nf create mode 100644 modules/nf-core/subworkflow/qc_trim.nf create mode 100644 modules/nf-core/subworkflow/sort_bam.nf diff --git a/conf/modules.config b/conf/modules.config index fcb8eae3d..491aae56d 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -17,7 +17,7 @@ params { publish_dir = "fastqc" publish_results = "all" } - 'trim_galore' { + 'trimgalore' { args = "--fastqc" suffix = "" publish_dir = "trim_galore" @@ -102,7 +102,7 @@ params { publish_dir = "bwa/mergedLibrary/picard_metrics" publish_results = "all" } - 'preseq_lc_extrap' { + 'preseq_lcextrap' { args = "-verbose -bam -seed 1" suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/preseq" diff --git a/main.nf b/main.nf index f2e3d0b0a..bff23dbe9 100755 --- a/main.nf +++ b/main.nf @@ -134,312 +134,212 @@ log.info Headers.nf_core(workflow, params.monochrome_logs) log.info summary.collect { k,v -> "${k.padRight(22)}: $v" }.join("\n") log.info "-\033[2m----------------------------------------------------\033[0m-" -/* - * Include local pipeline modules - */ -include { CHECK_SAMPLESHEET; - get_samplesheet_paths; - get_samplesheet_design } from './modules/local/check_samplesheet' -include { GTF2BED } from './modules/local/gtf2bed' -include { GET_CHROM_SIZES } from './modules/local/get_chrom_sizes' -include { MAKE_GENOME_FILTER } from './modules/local/make_genome_filter' -include { FILTER_BAM } from './modules/local/filter_bam' -include { REMOVE_BAM_ORPHANS } from './modules/local/remove_bam_orphans' -include { BEDTOOLS_GENOMECOV } from './modules/local/bedtools_genomecov' -include { OUTPUT_DOCUMENTATION } from './modules/local/output_documentation' -include { GET_SOFTWARE_VERSIONS } from './modules/local/get_software_versions' - -/* - * Include nf-core modules - */ -include { FASTQC } from './modules/nf-core/fastqc' -include { TRIM_GALORE } from './modules/nf-core/trim_galore' -include { BWA_INDEX } from './modules/nf-core/bwa_index' -include { BWA_MEM } from './modules/nf-core/bwa_mem' -include { SAMTOOLS_SORT } from './modules/nf-core/samtools_sort' -include { SAMTOOLS_INDEX } from './modules/nf-core/samtools_index' -include { SAMTOOLS_STATS } from './modules/nf-core/samtools_stats' -include { SAMTOOLS_IDXSTATS } from './modules/nf-core/samtools_idxstats' -include { SAMTOOLS_FLAGSTAT } from './modules/nf-core/samtools_flagstat' -include { PICARD_MERGESAMFILES } from './modules/nf-core/picard_mergesamfiles' -include { PICARD_MARKDUPLICATES } from './modules/nf-core/picard_markduplicates' -include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/picard_collectmultiplemetrics' -include { PRESEQ_LC_EXTRAP } from './modules/nf-core/preseq_lc_extrap' -include { UCSC_BEDRAPHTOBIGWIG } from './modules/nf-core/ucsc_bedgraphtobigwig' -include { DEEPTOOLS_COMPUTEMATRIX } from './modules/nf-core/deeptools_computematrix' -include { DEEPTOOLS_PLOTPROFILE } from './modules/nf-core/deeptools_plotprofile' -include { DEEPTOOLS_PLOTHEATMAP } from './modules/nf-core/deeptools_plotheatmap' -include { DEEPTOOLS_PLOTFINGERPRINT } from './modules/nf-core/deeptools_plotfingerprint' -include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/phantompeakqualtools' -//include { MACSC2_CALLPEAK } from './modules/nf-core/macs2_callpeak' -//include { HOMER_ANNOTATEPEAKS } from './modules/nf-core/homer_annotatepeaks' -//include { SUBREAD_FEATURECOUNTS } from './modules/nf-core/subread_featurecounts' -include { MULTIQC } from './modules/nf-core/multiqc' - -/* - * Check input samplesheet and get read channels - */ -workflow CHECK_INPUT { - take: - ch_input // file: /path/to/samplesheet.csv - seq_center // string: sequencing center for read group - check_samplesheet_opts // map: options for TrimGalore! module - - main: - CHECK_SAMPLESHEET (ch_input, check_samplesheet_opts) - .reads - .splitCsv(header:true, sep:',') - .map { get_samplesheet_paths(it, params.single_end, seq_center) } - .set { ch_reads } - - CHECK_SAMPLESHEET - .out - .controls - .splitCsv(header:true, sep:',') - .map { get_samplesheet_design(it, params.single_end) } - .set { ch_design } - - emit: - reads = ch_reads // channel: [ val(meta), [ reads ] ] - design = ch_design // channel: [ val(meta), [ reads ] ] -} - -/* - * Read QC and trimming - */ -workflow QC_TRIM { - take: - ch_reads // channel: [ val(meta), [ reads ] ] - skip_fastqc // boolean: true/false - skip_trimming // boolean: true/false - fastqc_opts // map: options for FastQC module - trim_galore_opts // map: options for TrimGalore! module - - main: - fastqc_html = Channel.empty() - fastqc_zip = Channel.empty() - fastqc_version = Channel.empty() - if (!skip_fastqc) { - FASTQC(ch_reads, fastqc_opts).html.set { fastqc_html } - fastqc_zip = FASTQC.out.zip - fastqc_version = FASTQC.out.version - } - - ch_trim_reads = ch_reads - trim_html = Channel.empty() - trim_zip = Channel.empty() - trim_log = Channel.empty() - trim_galore_version = Channel.empty() - if (!skip_trimming) { - TRIM_GALORE(ch_reads, trim_galore_opts).reads.set { ch_trim_reads } - trim_html = TRIM_GALORE.out.html - trim_zip = TRIM_GALORE.out.zip - trim_log = TRIM_GALORE.out.log - trim_galore_version = TRIM_GALORE.out.version - } - - emit: - fastqc_html // channel: [ val(meta), [ html ] ] - fastqc_zip // channel: [ val(meta), [ zip ] ] - fastqc_version // path: *.version.txt - - reads = ch_trim_reads // channel: [ val(meta), [ reads ] ] - trim_html // channel: [ val(meta), [ html ] ] - trim_zip // channel: [ val(meta), [ zip ] ] - trim_log // channel: [ val(meta), [ txt ] ] - trim_galore_version // path: *.version.txt -} +//////////////////////////////////////////////////// +/* -- IMPORT LOCAL MODULES/SUBWORKFLOWS -- */ +//////////////////////////////////////////////////// -/* - * Run SAMtools stats, flagstat and idxstats - */ -workflow BAM_STATS { - take: - ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] - samtools_opts // map: options for SAMTools modules - - main: - SAMTOOLS_STATS(ch_bam_bai, samtools_opts) - SAMTOOLS_FLAGSTAT(ch_bam_bai, samtools_opts) - SAMTOOLS_IDXSTATS(ch_bam_bai, samtools_opts) - - emit: - stats = SAMTOOLS_STATS.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = SAMTOOLS_FLAGSTAT.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = SAMTOOLS_IDXSTATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - samtools_version = SAMTOOLS_STATS.out.version // path: *.version.txt -} +include { GTF2BED } from './modules/local/process/gtf2bed' +include { GET_CHROM_SIZES } from './modules/local/process/get_chrom_sizes' +include { MAKE_GENOME_FILTER } from './modules/local/process/make_genome_filter' +include { BEDTOOLS_GENOMECOV } from './modules/local/process/bedtools_genomecov' +include { OUTPUT_DOCUMENTATION } from './modules/local/process/output_documentation' +include { GET_SOFTWARE_VERSIONS } from './modules/local/process/get_software_versions' -/* - * Sort, index BAM file and run samtools stats, flagstat and idxstats - */ -workflow SORT_BAM { - take: - ch_bam // channel: [ val(meta), [ bam ] ] - samtools_opts // map: options for SAMTools modules - - main: - SAMTOOLS_SORT(ch_bam, samtools_opts) - SAMTOOLS_INDEX(SAMTOOLS_SORT.out.bam, samtools_opts) - BAM_STATS(SAMTOOLS_SORT.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_opts) - - emit: - bam = SAMTOOLS_SORT.out.bam // channel: [ val(meta), [ bam ] ] - bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] - stats = BAM_STATS.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = BAM_STATS.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = BAM_STATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - samtools_version = SAMTOOLS_SORT.out.version // path: *.version.txt -} +include { CHECK_INPUT } from './modules/local/subworkflow/check_input' +include { CLEAN_BAM } from './modules/local/subworkflow/clean_bam' -/* - * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats - */ -workflow ALIGN { - take: - ch_reads // channel: [ val(meta), [ reads ] ] - ch_index // path: /path/to/index - ch_fasta // path: /path/to/genome.fasta - bwa_mem_opts // map: options for BWA MEM module - samtools_opts // map: options for SAMTools modules - - main: - BWA_MEM(ch_reads, ch_index, ch_fasta, bwa_mem_opts) - SORT_BAM(BWA_MEM.out.bam, samtools_opts) - - emit: - bam = SORT_BAM.out.bam // channel: [ val(meta), [ bam ] ] - bai = SORT_BAM.out.bai // channel: [ val(meta), [ bai ] ] - stats = SORT_BAM.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = SORT_BAM.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = SORT_BAM.out.idxstats // channel: [ val(meta), [ idxstats ] ] - bwa_version = BWA_MEM.out.version // path: *.version.txt - samtools_version = SORT_BAM.out.samtools_version // path: *.version.txt -} +//////////////////////////////////////////////////// +/* -- IMPORT NF-CORE MODULES/SUBWORKFLOWS -- */ +//////////////////////////////////////////////////// -/* - * Picard MarkDuplicates, sort, index BAM file and run samtools stats, flagstat and idxstats - */ -workflow MARKDUPLICATES { - take: - ch_bam // channel: [ val(meta), [ bam ] ] - markduplicates_opts // map: options for picard MarkDuplicates module - samtools_opts // map: options for SAMTools modules - - main: - PICARD_MARKDUPLICATES(ch_bam, markduplicates_opts) - SAMTOOLS_INDEX(PICARD_MARKDUPLICATES.out.bam, samtools_opts) - BAM_STATS(PICARD_MARKDUPLICATES.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_opts) - - emit: - bam = PICARD_MARKDUPLICATES.out.bam // channel: [ val(meta), [ bam ] ] - metrics = PICARD_MARKDUPLICATES.out.metrics // channel: [ val(meta), [ metrics ] ] - bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] - stats = BAM_STATS.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = BAM_STATS.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = BAM_STATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - picard_version = PICARD_MARKDUPLICATES.out.version // path: *.version.txt - samtools_version = SAMTOOLS_INDEX.out.version // path: *.version.txt -} +include { BWA_INDEX } from './modules/nf-core/software/bwa_index' +include { PICARD_MERGESAMFILES } from './modules/nf-core/software/picard_mergesamfiles' +include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/software/picard_collectmultiplemetrics' +include { PRESEQ_LCEXTRAP } from './modules/nf-core/software/preseq_lcextrap' +include { UCSC_BEDRAPHTOBIGWIG } from './modules/nf-core/software/ucsc_bedgraphtobigwig' +include { DEEPTOOLS_COMPUTEMATRIX } from './modules/nf-core/software/deeptools_computematrix' +include { DEEPTOOLS_PLOTPROFILE } from './modules/nf-core/software/deeptools_plotprofile' +include { DEEPTOOLS_PLOTHEATMAP } from './modules/nf-core/software/deeptools_plotheatmap' +include { DEEPTOOLS_PLOTFINGERPRINT } from './modules/nf-core/software/deeptools_plotfingerprint' +include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/software/phantompeakqualtools' +//include { MACSC2_CALLPEAK } from './modules/nf-core/software/macs2_callpeak' +//include { HOMER_ANNOTATEPEAKS } from './modules/nf-core/software/homer_annotatepeaks' +//include { SUBREAD_FEATURECOUNTS } from './modules/nf-core/software/subread_featurecounts' +include { MULTIQC } from './modules/nf-core/software/multiqc' + +include { QC_TRIM } from './modules/nf-core/subworkflow/qc_trim' +include { BAM_STATS } from './modules/nf-core/subworkflow/bam_stats' +include { SORT_BAM } from './modules/nf-core/subworkflow/sort_bam' +include { MAP_READS } from './modules/nf-core/subworkflow/map_reads' +include { MARK_DUPLICATES } from './modules/nf-core/subworkflow/mark_duplicates' -/* - * Filter BAM file - */ -workflow CLEAN_BAM { - take: - ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] - ch_bed // channel: [ bed ] - config // file: BAMtools filter JSON config file - filter_bam_opts // map: options for filter_bam module - rm_bam_orphans_opts // map: options for remove_bam_orphans module - samtools_opts // map: options for SAMTools modules - - main: - FILTER_BAM(ch_bam_bai, ch_bed, config, filter_bam_opts) - REMOVE_BAM_ORPHANS(FILTER_BAM.out.bam, rm_bam_orphans_opts) - SORT_BAM(REMOVE_BAM_ORPHANS.out.bam, samtools_opts) - - emit: - name_bam = REMOVE_BAM_ORPHANS.out.bam // channel: [ val(meta), [ bam ] ] - bam = SORT_BAM.out.bam // channel: [ val(meta), [ bam ] ] - bai = SORT_BAM.out.bai // channel: [ val(meta), [ bai ] ] - stats = SORT_BAM.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = SORT_BAM.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = SORT_BAM.out.idxstats // channel: [ val(meta), [ idxstats ] ] - bamtools_version = FILTER_BAM.out.version // path: *.version.txt -} +//////////////////////////////////////////////////// +/* -- RUN MAIN WORKFLOW -- */ +//////////////////////////////////////////////////// workflow { - // READ IN SAMPLESHEET, VALIDATE AND STAGE INPUT FILES - CHECK_INPUT(ch_input, params.seq_center, params.modules['check_samplesheet']) - - // PREPARE GENOME FILES - ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX(ch_fasta, params.modules['bwa_index']).index - if (makeBED) { GTF2BED(ch_gtf, params.modules['gtf2bed']).set { ch_gene_bed } } - MAKE_GENOME_FILTER(GET_CHROM_SIZES(ch_fasta, params.modules['get_chrom_sizes']).sizes, - ch_blacklist.ifEmpty([]), - params.modules['make_genome_filter']) - - // READ QC & TRIMMING + /* + * Read in samplesheet, validate and stage input files + */ + CHECK_INPUT ( + ch_input, + params.seq_center, + params.modules['check_samplesheet'] + ) + + /* + * Prepare genome files + */ + ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta, params.modules['bwa_index'] ).index + + if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf, params.modules['gtf2bed'] ) } + + MAKE_GENOME_FILTER ( + GET_CHROM_SIZES ( + ch_fasta, + params.modules['get_chrom_sizes'] + ).sizes, + ch_blacklist.ifEmpty([]), + params.modules['make_genome_filter'] + ) + + /* + * Read QC & trimming + */ nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' - params.modules['trim_galore'].args += nextseq - QC_TRIM(CHECK_INPUT.out.reads, - params.skip_fastqc, - params.skip_trimming, - params.modules['fastqc'], - params.modules['trim_galore']) - - // MAP READS & BAM QC + params.modules['trimgalore'].args += nextseq + QC_TRIM ( + CHECK_INPUT.out.reads, + params.skip_fastqc, + params.skip_trimming, + params.modules['fastqc'], + params.modules['trimgalore'] + ) + + /* + * Map reads & BAM QC + */ score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' params.modules['bwa_mem'].args += score - ALIGN(QC_TRIM.out.reads, ch_index, ch_fasta, params.modules['bwa_mem'], params.modules['samtools_sort_lib']) - - // MERGE RESEQUENCED BAM FILES - ALIGN + MAP_READS ( + QC_TRIM.out.reads, + ch_index, + ch_fasta, + params.modules['bwa_mem'], + params.modules['samtools_sort_lib'] + ) + + /* + * Merge resequenced BAM files + */ + MAP_READS .out .bam - .map { meta, bam -> - fmeta = meta.findAll { it.key != 'read_group' } - fmeta.id = fmeta.id.split('_')[0..-2].join('_') - [ fmeta, bam ] } + .map { + meta, bam -> + fmeta = meta.findAll { it.key != 'read_group' } + fmeta.id = fmeta.id.split('_')[0..-2].join('_') + [ fmeta, bam ] } .groupTuple(by: [0]) .map { it -> [ it[0], it[1].flatten() ] } .set { ch_sort_bam } - PICARD_MERGESAMFILES(ch_sort_bam, params.modules['picard_mergesamfiles']) - MARKDUPLICATES(PICARD_MERGESAMFILES.out.bam, params.modules['picard_markduplicates'], params.modules['samtools_sort_merged_lib']) - - // FILTER BAM FILES - // Fix getting name sorted BAM here for PE/SE - CLEAN_BAM(MARKDUPLICATES.out.bam.join(MARKDUPLICATES.out.bai, by: [0]), - MAKE_GENOME_FILTER.out.collect(), - ch_bamtools_filter_config, - params.modules['filter_bam'], - params.modules['remove_bam_orphans'], - params.modules['samtools_sort_filter']) - - // POST ALIGNMENT QC - PICARD_COLLECTMULTIPLEMETRICS(CLEAN_BAM.out.bam, ch_fasta, params.modules['picard_collectmultiplemetrics']) - //PRESEQ_LC_EXTRAP(CLEAN_BAM.out.bam, params.modules['preseq_lc_extrap']) - PHANTOMPEAKQUALTOOLS(CLEAN_BAM.out.bam, params.modules['phantompeakqualtools']) - - // COVERAGE TRACKS - BEDTOOLS_GENOMECOV(CLEAN_BAM.out.bam.join(CLEAN_BAM.out.flagstat, by: [0]), params.modules['bedtools_genomecov']) - UCSC_BEDRAPHTOBIGWIG(BEDTOOLS_GENOMECOV.out.bedgraph, GET_CHROM_SIZES.out.sizes, params.modules['ucsc_bedgraphtobigwig']) - - // COVERATE PLOTS - DEEPTOOLS_COMPUTEMATRIX(UCSC_BEDRAPHTOBIGWIG.out.bigwig, ch_gene_bed, params.modules['deeptools_computematrix']) - DEEPTOOLS_PLOTPROFILE(DEEPTOOLS_COMPUTEMATRIX.out.matrix, params.modules['deeptools_plotprofile']) - DEEPTOOLS_PLOTHEATMAP(DEEPTOOLS_COMPUTEMATRIX.out.matrix, params.modules['deeptools_plotheatmap']) + PICARD_MERGESAMFILES ( + ch_sort_bam, + params.modules['picard_mergesamfiles'] + ) + + /* + * Mark duplicates & filter BAM files + */ + MARK_DUPLICATES ( + PICARD_MERGESAMFILES.out.bam, + params.modules['picard_markduplicates'], + params.modules['samtools_sort_merged_lib'] + ) + + // Fix getting name sorted BAM here for PE/SE + CLEAN_BAM ( + MARK_DUPLICATES.out.bam.join(MARK_DUPLICATES.out.bai, by: [0]), + MAKE_GENOME_FILTER.out.collect(), + ch_bamtools_filter_config, + params.modules['filter_bam'], + params.modules['remove_bam_orphans'], + params.modules['samtools_sort_filter'] + ) + + /* + * Post alignment QC + */ + PICARD_COLLECTMULTIPLEMETRICS ( + CLEAN_BAM.out.bam, + ch_fasta, + params.modules['picard_collectmultiplemetrics'] + ) + + PRESEQ_LCEXTRAP ( + CLEAN_BAM.out.bam, + params.modules['preseq_lcextrap'] + ) + + PHANTOMPEAKQUALTOOLS ( + CLEAN_BAM.out.bam, + params.modules['phantompeakqualtools'] + ) + + /* + * Coverage tracks + */ + BEDTOOLS_GENOMECOV ( + CLEAN_BAM.out.bam.join(CLEAN_BAM.out.flagstat, by: [0]), + params.modules['bedtools_genomecov'] + ) + + UCSC_BEDRAPHTOBIGWIG ( + BEDTOOLS_GENOMECOV.out.bedgraph, + GET_CHROM_SIZES.out.sizes, + params.modules['ucsc_bedgraphtobigwig'] + ) + + /* + * Coverage plots + */ + DEEPTOOLS_COMPUTEMATRIX ( + UCSC_BEDRAPHTOBIGWIG.out.bigwig, + ch_gene_bed, + params.modules['deeptools_computematrix'] + ) + + DEEPTOOLS_PLOTPROFILE ( + DEEPTOOLS_COMPUTEMATRIX.out.matrix, + params.modules['deeptools_plotprofile'] + ) + + DEEPTOOLS_PLOTHEATMAP ( + DEEPTOOLS_COMPUTEMATRIX.out.matrix, + params.modules['deeptools_plotheatmap'] + ) // Join control BAM here too to generate plots with IP and CONTROL together params.modules['deeptools_plotfingerprint'].args += " --numberOfSamples $params.fingerprint_bins" - DEEPTOOLS_PLOTFINGERPRINT(CLEAN_BAM.out.bam.join(CLEAN_BAM.out.bai, by: [0]), params.modules['deeptools_plotfingerprint']) - - // PIPELINE REPORTING - GET_SOFTWARE_VERSIONS(params.modules['get_software_versions']) - OUTPUT_DOCUMENTATION(ch_output_docs, ch_output_docs_images, params.modules['output_documentation']) + DEEPTOOLS_PLOTFINGERPRINT ( + CLEAN_BAM.out.bam.join(CLEAN_BAM.out.bai, by: [0]), + params.modules['deeptools_plotfingerprint'] + ) + + /* + * Pipeline reporting + */ + GET_SOFTWARE_VERSIONS ( + params.modules['get_software_versions'] + ) + + OUTPUT_DOCUMENTATION ( + ch_output_docs, + ch_output_docs_images, + params.modules['output_documentation'] + ) // MULTIQC( // summary, @@ -448,15 +348,20 @@ workflow { // ) } -/* - * Send completion email - */ +//////////////////////////////////////////////////// +/* -- COMPLETION EMAIL -- */ +//////////////////////////////////////////////////// + workflow.onComplete { def multiqc_report = [] Completion.email(workflow, params, summary, run_name, baseDir, multiqc_report, log) Completion.summary(workflow, params, log) } +//////////////////////////////////////////////////// +/* -- THE END -- */ +//////////////////////////////////////////////////// + // /////////////////////////////////////////////////////////////////////////////// // /////////////////////////////////////////////////////////////////////////////// // /* -- -- */ diff --git a/modules/local/subworkflow/check_input.nf b/modules/local/subworkflow/check_input.nf index e69de29bb..445599082 100644 --- a/modules/local/subworkflow/check_input.nf +++ b/modules/local/subworkflow/check_input.nf @@ -0,0 +1,32 @@ +/* + * Check input samplesheet and get read channels + */ + +include { CHECK_SAMPLESHEET; + get_samplesheet_paths; + get_samplesheet_design } from '../process/check_samplesheet' + +workflow CHECK_INPUT { + take: + ch_input // file: /path/to/samplesheet.csv + seq_center // string: sequencing center for read group + check_samplesheet_opts // map: options for TrimGalore! module + + main: + CHECK_SAMPLESHEET (ch_input, check_samplesheet_opts) + .reads + .splitCsv(header:true, sep:',') + .map { get_samplesheet_paths(it, params.single_end, seq_center) } + .set { ch_reads } + + CHECK_SAMPLESHEET + .out + .controls + .splitCsv(header:true, sep:',') + .map { get_samplesheet_design(it, params.single_end) } + .set { ch_design } + + emit: + reads = ch_reads // channel: [ val(meta), [ reads ] ] + design = ch_design // channel: [ val(meta), [ reads ] ] +} diff --git a/modules/local/subworkflow/clean_bam.nf b/modules/local/subworkflow/clean_bam.nf new file mode 100644 index 000000000..b51099cf1 --- /dev/null +++ b/modules/local/subworkflow/clean_bam.nf @@ -0,0 +1,31 @@ +/* + * Filter BAM file + */ + +include { FILTER_BAM } from '../process/filter_bam' +include { REMOVE_BAM_ORPHANS } from '../process/remove_bam_orphans' +include { SORT_BAM } from '../../nf-core/subworkflow/sort_bam' + +workflow CLEAN_BAM { + take: + ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] + ch_bed // channel: [ bed ] + config // file: BAMtools filter JSON config file + filter_bam_opts // map: options for filter_bam module + rm_bam_orphans_opts // map: options for remove_bam_orphans module + samtools_opts // map: options for SAMTools modules + + main: + FILTER_BAM(ch_bam_bai, ch_bed, config, filter_bam_opts) + REMOVE_BAM_ORPHANS(FILTER_BAM.out.bam, rm_bam_orphans_opts) + SORT_BAM(REMOVE_BAM_ORPHANS.out.bam, samtools_opts) + + emit: + name_bam = REMOVE_BAM_ORPHANS.out.bam // channel: [ val(meta), [ bam ] ] + bam = SORT_BAM.out.bam // channel: [ val(meta), [ bam ] ] + bai = SORT_BAM.out.bai // channel: [ val(meta), [ bai ] ] + stats = SORT_BAM.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = SORT_BAM.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = SORT_BAM.out.idxstats // channel: [ val(meta), [ idxstats ] ] + bamtools_version = FILTER_BAM.out.version // path: *.version.txt +} diff --git a/modules/nf-core/software/preseq_lc_extrap.nf b/modules/nf-core/software/preseq_lcextrap.nf similarity index 94% rename from modules/nf-core/software/preseq_lc_extrap.nf rename to modules/nf-core/software/preseq_lcextrap.nf index b87a038be..24af85664 100644 --- a/modules/nf-core/software/preseq_lc_extrap.nf +++ b/modules/nf-core/software/preseq_lcextrap.nf @@ -1,4 +1,4 @@ -process PRESEQ_LC_EXTRAP { +process PRESEQ_LCEXTRAP { tag "$meta.id" label 'process_medium' label 'error_ignore' diff --git a/modules/nf-core/software/trim_galore.nf b/modules/nf-core/software/trimgalore.nf similarity index 96% rename from modules/nf-core/software/trim_galore.nf rename to modules/nf-core/software/trimgalore.nf index a0fd544f7..eaecdf8fe 100644 --- a/modules/nf-core/software/trim_galore.nf +++ b/modules/nf-core/software/trimgalore.nf @@ -1,4 +1,4 @@ -process TRIM_GALORE { +process TRIMGALORE { tag "$meta.id" label 'process_high' publishDir "${params.outdir}/${opts.publish_dir}", diff --git a/modules/nf-core/subworkflow/bam_stats.nf b/modules/nf-core/subworkflow/bam_stats.nf new file mode 100644 index 000000000..95c1bb24d --- /dev/null +++ b/modules/nf-core/subworkflow/bam_stats.nf @@ -0,0 +1,24 @@ +/* + * Run SAMtools stats, flagstat and idxstats + */ + +include { SAMTOOLS_STATS } from '../software/samtools_stats' +include { SAMTOOLS_IDXSTATS } from '../software/samtools_idxstats' +include { SAMTOOLS_FLAGSTAT } from '../software/samtools_flagstat' + +workflow BAM_STATS { + take: + ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] + samtools_opts // map: options for SAMTools modules + + main: + SAMTOOLS_STATS(ch_bam_bai, samtools_opts) + SAMTOOLS_FLAGSTAT(ch_bam_bai, samtools_opts) + SAMTOOLS_IDXSTATS(ch_bam_bai, samtools_opts) + + emit: + stats = SAMTOOLS_STATS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = SAMTOOLS_FLAGSTAT.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = SAMTOOLS_IDXSTATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + samtools_version = SAMTOOLS_STATS.out.version // path: *.version.txt +} diff --git a/modules/nf-core/subworkflow/map_reads.nf b/modules/nf-core/subworkflow/map_reads.nf new file mode 100644 index 000000000..1e310c8b0 --- /dev/null +++ b/modules/nf-core/subworkflow/map_reads.nf @@ -0,0 +1,28 @@ +/* + * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats + */ + +include { BWA_MEM } from '../software/bwa_mem' +include { SORT_BAM } from './sort_bam' + +workflow MAP_READS { + take: + ch_reads // channel: [ val(meta), [ reads ] ] + ch_index // path: /path/to/index + ch_fasta // path: /path/to/genome.fasta + bwa_mem_opts // map: options for BWA MEM module + samtools_opts // map: options for SAMTools modules + + main: + BWA_MEM(ch_reads, ch_index, ch_fasta, bwa_mem_opts) + SORT_BAM(BWA_MEM.out.bam, samtools_opts) + + emit: + bam = SORT_BAM.out.bam // channel: [ val(meta), [ bam ] ] + bai = SORT_BAM.out.bai // channel: [ val(meta), [ bai ] ] + stats = SORT_BAM.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = SORT_BAM.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = SORT_BAM.out.idxstats // channel: [ val(meta), [ idxstats ] ] + bwa_version = BWA_MEM.out.version // path: *.version.txt + samtools_version = SORT_BAM.out.samtools_version // path: *.version.txt +} diff --git a/modules/nf-core/subworkflow/mark_duplicates.nf b/modules/nf-core/subworkflow/mark_duplicates.nf new file mode 100644 index 000000000..2d326a083 --- /dev/null +++ b/modules/nf-core/subworkflow/mark_duplicates.nf @@ -0,0 +1,29 @@ +/* + * Picard MarkDuplicates, sort, index BAM file and run samtools stats, flagstat and idxstats + */ + +include { PICARD_MARKDUPLICATES } from '../software/picard_markduplicates' +include { SAMTOOLS_INDEX } from '../software/samtools_index' +include { BAM_STATS } from './bam_stats' + +workflow MARK_DUPLICATES { + take: + ch_bam // channel: [ val(meta), [ bam ] ] + markduplicates_opts // map: options for picard MarkDuplicates module + samtools_opts // map: options for SAMTools modules + + main: + PICARD_MARKDUPLICATES(ch_bam, markduplicates_opts) + SAMTOOLS_INDEX(PICARD_MARKDUPLICATES.out.bam, samtools_opts) + BAM_STATS(PICARD_MARKDUPLICATES.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_opts) + + emit: + bam = PICARD_MARKDUPLICATES.out.bam // channel: [ val(meta), [ bam ] ] + metrics = PICARD_MARKDUPLICATES.out.metrics // channel: [ val(meta), [ metrics ] ] + bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_STATS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_STATS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_STATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + picard_version = PICARD_MARKDUPLICATES.out.version // path: *.version.txt + samtools_version = SAMTOOLS_INDEX.out.version // path: *.version.txt +} diff --git a/modules/nf-core/subworkflow/preprocess.nf b/modules/nf-core/subworkflow/preprocess.nf deleted file mode 100644 index e69de29bb..000000000 diff --git a/modules/nf-core/subworkflow/qc_trim.nf b/modules/nf-core/subworkflow/qc_trim.nf new file mode 100644 index 000000000..f99089a02 --- /dev/null +++ b/modules/nf-core/subworkflow/qc_trim.nf @@ -0,0 +1,49 @@ +/* + * Read QC and trimming + */ + +include { FASTQC } from '../software/fastqc' +include { TRIMGALORE } from '../software/trimgalore' + +workflow QC_TRIM { + take: + ch_reads // channel: [ val(meta), [ reads ] ] + skip_fastqc // boolean: true/false + skip_trimming // boolean: true/false + fastqc_opts // map: options for FastQC module + trim_galore_opts // map: options for TrimGalore! module + + main: + fastqc_html = Channel.empty() + fastqc_zip = Channel.empty() + fastqc_version = Channel.empty() + if (!skip_fastqc) { + FASTQC(ch_reads, fastqc_opts).html.set { fastqc_html } + fastqc_zip = FASTQC.out.zip + fastqc_version = FASTQC.out.version + } + + ch_trim_reads = ch_reads + trim_html = Channel.empty() + trim_zip = Channel.empty() + trim_log = Channel.empty() + trim_galore_version = Channel.empty() + if (!skip_trimming) { + TRIMGALORE(ch_reads, trim_galore_opts).reads.set { ch_trim_reads } + trim_html = TRIMGALORE.out.html + trim_zip = TRIMGALORE.out.zip + trim_log = TRIMGALORE.out.log + trim_galore_version = TRIMGALORE.out.version + } + + emit: + fastqc_html // channel: [ val(meta), [ html ] ] + fastqc_zip // channel: [ val(meta), [ zip ] ] + fastqc_version // path: *.version.txt + + reads = ch_trim_reads // channel: [ val(meta), [ reads ] ] + trim_html // channel: [ val(meta), [ html ] ] + trim_zip // channel: [ val(meta), [ zip ] ] + trim_log // channel: [ val(meta), [ txt ] ] + trim_galore_version // path: *.version.txt +} diff --git a/modules/nf-core/subworkflow/sort_bam.nf b/modules/nf-core/subworkflow/sort_bam.nf new file mode 100644 index 000000000..dd4f0b2c7 --- /dev/null +++ b/modules/nf-core/subworkflow/sort_bam.nf @@ -0,0 +1,26 @@ +/* + * Sort, index BAM file and run samtools stats, flagstat and idxstats + */ + +include { SAMTOOLS_SORT } from '../software/samtools_sort' +include { SAMTOOLS_INDEX } from '../software/samtools_index' +include { BAM_STATS } from './bam_stats' + +workflow SORT_BAM { + take: + ch_bam // channel: [ val(meta), [ bam ] ] + samtools_opts // map: options for SAMTools modules + + main: + SAMTOOLS_SORT(ch_bam, samtools_opts) + SAMTOOLS_INDEX(SAMTOOLS_SORT.out.bam, samtools_opts) + BAM_STATS(SAMTOOLS_SORT.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_opts) + + emit: + bam = SAMTOOLS_SORT.out.bam // channel: [ val(meta), [ bam ] ] + bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_STATS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_STATS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_STATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + samtools_version = SAMTOOLS_SORT.out.version // path: *.version.txt +} From 0486725b06b837a19562cfe26c0172666c223e9a Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 24 Jul 2020 12:06:53 +0100 Subject: [PATCH 052/538] Update environment --- environment.yml | 28 ++++++++++++++-------------- 1 file changed, 14 insertions(+), 14 deletions(-) diff --git a/environment.yml b/environment.yml index c7efd4d9b..7beb5868a 100644 --- a/environment.yml +++ b/environment.yml @@ -22,26 +22,26 @@ dependencies: - conda-forge::r-lattice=0.20_41 - conda-forge::r-upsetr=1.4.0 - conda-forge::r-xfun=0.15 - - conda-forge::gawk=5.1.0 - - conda-forge::pigz=2.3.4 ## Required for TrimGalore multi-threading + #- conda-forge::gawk=5.1.0 + #- conda-forge::pigz=2.3.4 ## Required for TrimGalore multi-threading ## bioconda packages - - bioconda::fastqc=0.11.9 - - bioconda::trim-galore=0.6.5 - - bioconda::bwa=0.7.17 + #- bioconda::fastqc=0.11.9 + #- bioconda::trim-galore=0.6.5 + #- bioconda::bwa=0.7.17 - bioconda::samtools=1.10 - - bioconda::picard=2.23.1 + #- bioconda::picard=2.23.1 - bioconda::bamtools=2.5.1 - bioconda::pysam=0.15.3 - bioconda::bedtools=2.29.2 - - bioconda::ucsc-bedgraphtobigwig=357 - - bioconda::deeptools=3.4.3 - - bioconda::macs2=2.2.7.1 - - bioconda::homer=4.11 - - bioconda::subread=2.0.1 - - bioconda::phantompeakqualtools=1.2.2 - - bioconda::preseq=2.0.3 - - bioconda::multiqc=1.9 + #- bioconda::ucsc-bedgraphtobigwig=357 + #- bioconda::deeptools=3.4.3 + #- bioconda::macs2=2.2.7.1 + #- bioconda::homer=4.11 + #- bioconda::subread=2.0.1 + #- bioconda::phantompeakqualtools=1.2.2 + #- bioconda::preseq=2.0.3 + #- bioconda::multiqc=1.9 - bioconda::bioconductor-biocparallel=1.20.0 - bioconda::bioconductor-deseq2=1.26.0 - bioconda::bioconductor-vsn=3.54.0 From 2dd9f21d265997495d0c17f58556fc1dbaca22f4 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 24 Jul 2020 14:56:26 +0100 Subject: [PATCH 053/538] Refactor input reads channel --- bin/check_samplesheet.py | 330 ++++++++++----------- modules/local/process/check_samplesheet.nf | 29 +- modules/local/subworkflow/check_input.nf | 18 +- 3 files changed, 168 insertions(+), 209 deletions(-) diff --git a/bin/check_samplesheet.py b/bin/check_samplesheet.py index 921349ecb..e81d5cdc9 100755 --- a/bin/check_samplesheet.py +++ b/bin/check_samplesheet.py @@ -1,191 +1,173 @@ #!/usr/bin/env python -####################################################################### -####################################################################### -## Created on April 4th 2019 to check nf-core/chipseq design file -####################################################################### -####################################################################### - import os import sys +import errno import argparse -############################################ -############################################ -## PARSE ARGUMENTS -############################################ -############################################ - -Description = 'Reformat nf-core/chipseq samplesheet and check its contents.' -Epilog = "Example usage: python check_samplesheet.py " - -argParser = argparse.ArgumentParser(description=Description, epilog=Epilog) - -## REQUIRED PARAMETERS -argParser.add_argument('DESIGN_FILE', help="Input samplesheet/design file.") -argParser.add_argument('READ_MAPPING_FILE', help="Output design file containing sample ids and reads.") -argParser.add_argument('CONTROL_MAPPING_FILE', help="Output design file containing ip vs control mappings.") -args = argParser.parse_args() - -############################################ -############################################ -## MAIN FUNCTION -############################################ -############################################ - -def reformat_design(DesignFile,ReadMappingFile,ControlMappingFile): - - ERROR_STR = 'ERROR: Please check design file' - HEADER = ['group', 'replicate', 'fastq_1', 'fastq_2', 'antibody', 'control'] - - ## CHECK HEADER - fin = open(DesignFile,'r') - header = fin.readline().strip().split(',') - if header != HEADER: - print("{} header: {} != {}".format(ERROR_STR,','.join(header),','.join(HEADER))) - sys.exit(1) - - numColList = [] - sampleMappingDict = {} - antibodyDict = {} - while True: - line = fin.readline() - if line: - lspl = [x.strip() for x in line.strip().split(',')] - group,replicate,fastQFiles,antibody,control = lspl[0],lspl[1],[x for x in lspl[2:-2] if x],lspl[-2],lspl[-1] - - ## CHECK VALID NUMBER OF COLUMNS PER SAMPLE - numCols = len(lspl) - if numCols not in [6]: - print("{}: Invalid number of columns (should be 6)!\nLine: '{}'".format(ERROR_STR,line.strip())) - sys.exit(1) - numColList.append(numCols) - - ## CHECK GROUP ID DOESNT CONTAIN SPACES - if group.find(' ') != -1: - print("{}: Group id contains spaces!\nLine: '{}'".format(ERROR_STR,line.strip())) - sys.exit(1) - - ## CHECK REPLICATE COLUMN IS INTEGER + +def parse_args(args=None): + Description = "Reformat nf-core/chipseq samplesheet file and check its contents." + Epilog = "Example usage: python check_samplesheet.py " + + parser = argparse.ArgumentParser(description=Description, epilog=Epilog) + parser.add_argument("FILE_IN", help="Input samplesheet file.") + parser.add_argument("FILE_OUT", help="Output file.") + return parser.parse_args(args) + + +def make_dir(path): + if len(path) > 0: + try: + os.makedirs(path) + except OSError as exception: + if exception.errno != errno.EEXIST: + raise exception + + +def print_error(error, context='Line', context_str=''): + error_str = "ERROR: Please check samplesheet -> {}".format(error) + if context != '' and context_str != '': + error_str = "ERROR: Please check samplesheet -> {}\n{}: '{}'".format(error, context.strip(), context_str.strip()) + print(error_str) + sys.exit(1) + + +def check_samplesheet(file_in, file_out): + """ + This function checks that the samplesheet follows the following structure: + + group,replicate,fastq_1,fastq_2,antibody,control + CTCF_IP,1,CTCF_IP_1.fastq.gz,CTCF_IP_2.fastq.gz,CTCF,INPUT + INPUT,1,INPUT_1.fastq.gz,INPUT_IP_2.fastq.gz,, + """ + + sample_run_dict = {} + antibody_dict = {} + with open(file_in, "r") as fin: + + ## Check header + HEADER = ['group', 'replicate', 'fastq_1', 'fastq_2', 'antibody', 'control'] + header = fin.readline().strip().split(",") + if header != HEADER: + print("ERROR: Please check samplesheet header -> {} != {}".format(",".join(header), ",".join(HEADER))) + sys.exit(1) + + ## Check sample entries + for line in fin: + lspl = [x.strip() for x in line.strip().split(",")] + sample, replicate, fastq_1, fastq_2, antibody, control = lspl + + ## Check valid number of columns per row + if len(lspl) != len(header): + print_error("Invalid number of columns (minimum = {})!".format(len(header)), 'Line', line) + + num_cols = len([x for x in lspl if x]) + if num_cols < 3: + print_error("Invalid number of populated columns (minimum = 3)!", 'Line', line) + + ## Check sample name entries + if sample: + if sample.find(" ") != -1: + print_error("Group entry contains spaces!", 'Line', line) + else: + print_error("Group entry has not been specified!", 'Line', line) + + ## Check replicate entry is integer if not replicate.isdigit(): - print("{}: Replicate id not an integer!\nLine: '{}'".format(ERROR_STR,line.strip())) - sys.exit(1) + print_error("Replicate id not an integer!", 'Line', line) replicate = int(replicate) - for fastq in fastQFiles: - ## CHECK FASTQ FILE EXTENSION - if fastq[-9:] != '.fastq.gz' and fastq[-6:] != '.fq.gz': - print("{}: FastQ file has incorrect extension (has to be '.fastq.gz' or 'fq.gz') - {}\nLine: '{}'".format(ERROR_STR,fastq,line.strip())) - sys.exit(1) - - ## CREATE GROUP MAPPING DICT = {GROUP_ID: {REPLICATE_ID:[[FASTQ_FILES]]} - if group not in sampleMappingDict: - sampleMappingDict[group] = {} - if replicate not in sampleMappingDict[group]: - sampleMappingDict[group][replicate] = [] - sampleMappingDict[group][replicate].append(fastQFiles) + ## Check FastQ file extension + for fastq in [fastq_1, fastq_2]: + if fastq: + if fastq.find(" ") != -1: + print_error("FastQ file contains spaces!", 'Line', line) + if not fastq.endswith(".fastq.gz") and not fastq.endswith(".fq.gz"): + print_error("FastQ file does not have extension '.fastq.gz' or '.fq.gz'!", 'Line', line) - ## CHECK BOTH ANTIBODY AND CONTROL COLUMNS HAVE VALID VALUES + ## Check antibody and control columns have valid values if antibody: if antibody.find(' ') != -1: - print("{}: Antibody id contains spaces!\nLine: '{}'".format(ERROR_STR,line.strip())) - sys.exit(1) + print_error("Antibody id contains spaces!", line) if not control: - print("{}: both Antibody and Control must be specified!\nLine: '{}'".format(ERROR_STR,line.strip())) - sys.exit(1) + print_error("Both antibody and control columns must be specified!", 'Line', line) if control: if control.find(' ') != -1: - print("{}: Control id contains spaces!\nLine: '{}'".format(ERROR_STR,line.strip())) - sys.exit(1) + print_error("Control id contains spaces!", line) if not antibody: - print("{}: both Antibody and Control must be specified!\nLine: '{}'".format(ERROR_STR,line.strip())) - sys.exit(1) - - ## CREATE ANTIBODY MAPPING CONTROL DICT + print_error("Both antibody and control columns must be specified!", 'Line', line) if antibody and control: - antibodyDict[group] = (antibody,control) - - else: - fin.close() - break - - ## CHECK IF DATA IS PAIRED-END OR SINGLE-END AND NOT A MIXTURE - if min(numColList) != max(numColList): - print("{}: Mixture of paired-end and single-end reads!".format(ERROR_STR)) - sys.exit(1) - - ## CHECK IF ANTIBODY AND CONTROL COLUMNS HAVE BEEN SPECIFIED AT LEAST ONCE - if len(antibodyDict) == 0: - print("{}: Antibody and Control must be specified at least once!".format(ERROR_STR)) - sys.exit(1) - - ## WRITE READ MAPPING FILE - antibodyGroupDict = {} - fout = open(ReadMappingFile,'w') - fout.write(','.join(['sample_id','fastq_1','fastq_2']) + '\n') - for group in sorted(sampleMappingDict.keys()): - - ## CHECK THAT REPLICATE IDS ARE IN FORMAT 1.. - uniq_rep_ids = set(sampleMappingDict[group].keys()) - if len(uniq_rep_ids) != max(uniq_rep_ids): - print("{}: Replicate IDs must start with 1..\nGroup: {}, Replicate IDs: {}".format(ERROR_STR,group,list(uniq_rep_ids))) - sys.exit(1) - - ## RECONSTRUCT LINE FOR SAMPLE IN DESIGN - for replicate in sorted(sampleMappingDict[group].keys()): - for idx in range(len(sampleMappingDict[group][replicate])): - fastQFiles = sampleMappingDict[group][replicate][idx] - - ## GET SAMPLE_ID,FASTQ_1,FASTQ_2 COLUMNS - sample_id = "{}_R{}_T{}".format(group,replicate,idx+1) - oList = [sample_id] + fastQFiles - if len(fastQFiles) == 1: - oList += [''] - fout.write(','.join(oList) + '\n') - - ## EXTRAPOLATE CONTROL COLUMN - if group in antibodyDict: - antibody,control = antibodyDict[group] - if control in sampleMappingDict.keys(): - control_id = "{}_R1".format(control) - if replicate in sampleMappingDict[control]: - control_id = "{}_R{}".format(control,replicate) - if antibody not in antibodyGroupDict: - antibodyGroupDict[antibody] = {} - if group not in antibodyGroupDict[antibody]: - antibodyGroupDict[antibody][group] = [] - antibodyList = [sample_id[:-3],control_id] - if not antibodyList in antibodyGroupDict[antibody][group]: - antibodyGroupDict[antibody][group].append(antibodyList) - else: - print("{}: Control id not a valid group\nControl id: {}, Valid Groups: {}".format(ERROR_STR,control,sorted(sampleMappingDict.keys()))) - sys.exit(1) - fout.close() - - ## WRITE SAMPLE TO CONTROL MAPPING FILE - fout = open(ControlMappingFile,'w') - fout.write(','.join(['sample_id','control_id','antibody','replicatesExist','multipleGroups']) + '\n') - for antibody in sorted(antibodyGroupDict.keys()): - repsExist = '0' - if max([len(x) for x in antibodyGroupDict[antibody].values()]) > 1: - repsExist = '1' - multipleGroups = '0' - if len(antibodyGroupDict[antibody].keys()) > 1: - multipleGroups = '1' - for group in sorted(antibodyGroupDict[antibody].keys()): - for antibodyList in antibodyGroupDict[antibody][group]: - fout.write(','.join(antibodyList+[antibody,repsExist,multipleGroups]) + '\n') - fout.close() - -############################################ -############################################ -## RUN FUNCTION -############################################ -############################################ - -reformat_design(DesignFile=args.DESIGN_FILE,ReadMappingFile=args.READ_MAPPING_FILE,ControlMappingFile=args.CONTROL_MAPPING_FILE) - -############################################ -############################################ -############################################ -############################################ + antibody_dict[sample] = (antibody,control) + + ## Auto-detect paired-end/single-end + sample_info = [] ## [single_end, fastq_1, fastq_2] + if sample and fastq_1 and fastq_2: ## Paired-end short reads + sample_info = ["0", fastq_1, fastq_2] + elif sample and fastq_1 and not fastq_2: ## Single-end short reads + sample_info = ["1", fastq_1, fastq_2] + else: + print_error("Invalid combination of columns provided!", 'Line', line) + + ## Create sample mapping dictionary = {sample: {replicate : [ single_end, fastq_1, fastq_2 ]}} + if sample not in sample_run_dict: + sample_run_dict[sample] = {} + if replicate not in sample_run_dict[sample]: + sample_run_dict[sample][replicate] = [sample_info] + else: + if sample_info in sample_run_dict[sample][replicate]: + print_error("Samplesheet contains duplicate rows!", 'Line', line) + else: + sample_run_dict[sample].append(sample_info) + + ## Check if antibody and control columns have been specified at least once + if len(antibody_dict) == 0: + print_error("Antibody and control must be specified at least once!", '', '') + + ## Write validated samplesheet with appropriate columns + antibody_group_dict = {} + if len(sample_run_dict) > 0: + out_dir = os.path.dirname(file_out) + make_dir(out_dir) + with open(file_out, "w") as fout: + + fout.write(",".join(["sample", "single_end", "fastq_1", "fastq_2", "antibody", "control"]) + "\n") + for sample in sorted(sample_run_dict.keys()): + + ## Check that replicate ids are in format 1.. + uniq_rep_ids = set(sample_run_dict[sample].keys()) + if len(uniq_rep_ids) != max(uniq_rep_ids): + print_error("Replicate IDs must start with 1..!", 'Group', sample) + + for replicate in sorted(sample_run_dict[sample].keys()): + + ## Check that multiple runs of the same sample are of the same datatype + if not all(x[0] == sample_run_dict[sample][replicate][0][0] for x in sample_run_dict[sample][replicate]): + print_error("Multiple runs of a sample must be of the same datatype!", 'Group', sample) + + for idx, sample_info in enumerate(sample_run_dict[sample][replicate]): + sample_id = "{}_R{}_T{}".format(sample,replicate,idx+1) + oList = [sample_id] + sample_info + + ## Extrapolate group column + if sample in antibody_dict: + antibody,control = antibody_dict[sample] + if control in sample_run_dict.keys(): + control_id = "{}_R1".format(control) + if replicate in sample_run_dict[control]: + control_id = "{}_R{}".format(control,replicate) + oList += [antibody, control_id] + else: + print_error("Control id not a valid group: {}!".format(control), 'Valid Groups', sorted(sample_run_dict.keys())) + else: + oList += 2 * [''] + fout.write(','.join(oList) + '\n') + + +def main(args=None): + args = parse_args(args) + check_samplesheet(args.FILE_IN, args.FILE_OUT) + + +if __name__ == "__main__": + sys.exit(main()) diff --git a/modules/local/process/check_samplesheet.nf b/modules/local/process/check_samplesheet.nf index 00184902a..0a1f64c34 100755 --- a/modules/local/process/check_samplesheet.nf +++ b/modules/local/process/check_samplesheet.nf @@ -14,20 +14,21 @@ process CHECK_SAMPLESHEET { val opts output: - path 'samplesheet_reads.csv', emit: reads - path 'samplesheet_controls.csv', emit: controls + path '*.csv' script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ """ - check_samplesheet.py $samplesheet samplesheet_reads.csv samplesheet_controls.csv + check_samplesheet.py $samplesheet samplesheet.valid.csv """ } // Function to get list of [ meta, [ fastq_1, fastq_2 ] ] -def get_samplesheet_paths(LinkedHashMap row, boolean single_end, String seq_center) { +def get_samplesheet_paths(LinkedHashMap row, String seq_center) { def meta = [:] - meta.id = row.sample_id - meta.single_end = single_end + meta.id = row.sample + meta.single_end = row.single_end.toBoolean() + meta.antibody = row.antibody + meta.control = row.control def rg = "\'@RG\\tID:${meta.id}\\tSM:${meta.id.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${meta.id}\\tPU:1\'" if (seq_center) { @@ -36,24 +37,10 @@ def get_samplesheet_paths(LinkedHashMap row, boolean single_end, String seq_cent meta.read_group = rg def array = [] - if (single_end) { + if (meta.single_end) { array = [ meta, [ file(row.fastq_1, checkIfExists: true) ] ] } else { array = [ meta, [ file(row.fastq_1, checkIfExists: true), file(row.fastq_2, checkIfExists: true) ] ] } return array } - -// Function to get list of [sample, control, antibody, replicatesExist?, multipleGroups?] -def get_samplesheet_design(LinkedHashMap row, boolean single_end) { - def meta = [:] - meta.id = row.sample_id - meta.single_end = single_end - meta.antibody = row.antibody - meta.control_id = row.control_id - meta.reps_exist = row.replicatesExist.toBoolean() - meta.groups_exist = row.multipleGroups.toBoolean() - - //return [ row.sample_id, row.control_id, row.antibody, row.replicatesExist.toBoolean(), row.multipleGroups.toBoolean() ] - return meta -} diff --git a/modules/local/subworkflow/check_input.nf b/modules/local/subworkflow/check_input.nf index 445599082..91596732c 100644 --- a/modules/local/subworkflow/check_input.nf +++ b/modules/local/subworkflow/check_input.nf @@ -3,30 +3,20 @@ */ include { CHECK_SAMPLESHEET; - get_samplesheet_paths; - get_samplesheet_design } from '../process/check_samplesheet' + get_samplesheet_paths } from '../process/check_samplesheet' workflow CHECK_INPUT { take: ch_input // file: /path/to/samplesheet.csv seq_center // string: sequencing center for read group - check_samplesheet_opts // map: options for TrimGalore! module + check_samplesheet_opts // map: options for check_samplesheet module main: CHECK_SAMPLESHEET (ch_input, check_samplesheet_opts) - .reads .splitCsv(header:true, sep:',') - .map { get_samplesheet_paths(it, params.single_end, seq_center) } + .map { get_samplesheet_paths(it, seq_center) } .set { ch_reads } - CHECK_SAMPLESHEET - .out - .controls - .splitCsv(header:true, sep:',') - .map { get_samplesheet_design(it, params.single_end) } - .set { ch_design } - emit: - reads = ch_reads // channel: [ val(meta), [ reads ] ] - design = ch_design // channel: [ val(meta), [ reads ] ] + reads = ch_reads // channel: [ val(meta), [ reads ] ] } From caa1eedbf947efe25553cbafc53e4a391ffe29d7 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 24 Jul 2020 15:51:18 +0100 Subject: [PATCH 054/538] Use base expansion for genome indices --- conf/igenomes.config | 148 +++++++++++++++++++++---------------------- 1 file changed, 74 insertions(+), 74 deletions(-) diff --git a/conf/igenomes.config b/conf/igenomes.config index 2de924228..8fb4b874e 100644 --- a/conf/igenomes.config +++ b/conf/igenomes.config @@ -12,8 +12,8 @@ params { genomes { 'GRCh37' { fasta = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/Genes/genes.gtf" @@ -25,8 +25,8 @@ params { } 'GRCh38' { fasta = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Annotation/Genes/genes.gtf" @@ -37,8 +37,8 @@ params { } 'GRCm38' { fasta = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/Genes/genes.gtf" @@ -50,8 +50,8 @@ params { } 'TAIR10' { fasta = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/Genes/genes.gtf" @@ -61,8 +61,8 @@ params { } 'EB2' { fasta = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/Genes/genes.gtf" @@ -71,8 +71,8 @@ params { } 'UMD3.1' { fasta = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/Genes/genes.gtf" @@ -82,8 +82,8 @@ params { } 'WBcel235' { fasta = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Annotation/Genes/genes.gtf" @@ -93,8 +93,8 @@ params { } 'CanFam3.1' { fasta = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/Genes/genes.gtf" @@ -104,8 +104,8 @@ params { } 'GRCz10' { fasta = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Annotation/Genes/genes.gtf" @@ -114,8 +114,8 @@ params { } 'BDGP6' { fasta = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Annotation/Genes/genes.gtf" @@ -125,8 +125,8 @@ params { } 'EquCab2' { fasta = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/Genes/genes.gtf" @@ -136,8 +136,8 @@ params { } 'EB1' { fasta = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/Genes/genes.gtf" @@ -146,8 +146,8 @@ params { } 'Galgal4' { fasta = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Annotation/Genes/genes.gtf" @@ -156,8 +156,8 @@ params { } 'Gm01' { fasta = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/Genes/genes.gtf" @@ -166,8 +166,8 @@ params { } 'Mmul_1' { fasta = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/Genes/genes.gtf" @@ -177,8 +177,8 @@ params { } 'IRGSP-1.0' { fasta = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Annotation/Genes/genes.gtf" @@ -187,8 +187,8 @@ params { } 'CHIMP2.1.4' { fasta = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/Genes/genes.gtf" @@ -198,8 +198,8 @@ params { } 'Rnor_6.0' { fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Annotation/Genes/genes.gtf" @@ -208,8 +208,8 @@ params { } 'R64-1-1' { fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Annotation/Genes/genes.gtf" @@ -219,8 +219,8 @@ params { } 'EF2' { fasta = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/Genes/genes.gtf" @@ -231,8 +231,8 @@ params { } 'Sbi1' { fasta = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/Genes/genes.gtf" @@ -241,8 +241,8 @@ params { } 'Sscrofa10.2' { fasta = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/Genes/genes.gtf" @@ -252,8 +252,8 @@ params { } 'AGPv3' { fasta = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Annotation/Genes/genes.gtf" @@ -262,8 +262,8 @@ params { } 'hg38' { fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Annotation/Genes/genes.gtf" @@ -274,8 +274,8 @@ params { } 'hg19' { fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/Genes/genes.gtf" @@ -287,8 +287,8 @@ params { } 'mm10' { fasta = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/Genes/genes.gtf" @@ -300,8 +300,8 @@ params { } 'bosTau8' { fasta = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Annotation/Genes/genes.gtf" @@ -310,8 +310,8 @@ params { } 'ce10' { fasta = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/Genes/genes.gtf" @@ -322,8 +322,8 @@ params { } 'canFam3' { fasta = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/Genes/genes.gtf" @@ -333,8 +333,8 @@ params { } 'danRer10' { fasta = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.gtf" @@ -343,8 +343,8 @@ params { } 'dm6' { fasta = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Annotation/Genes/genes.gtf" @@ -354,8 +354,8 @@ params { } 'equCab2' { fasta = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/Genes/genes.gtf" @@ -365,8 +365,8 @@ params { } 'galGal4' { fasta = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/Genes/genes.gtf" @@ -376,8 +376,8 @@ params { } 'panTro4' { fasta = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/Genes/genes.gtf" @@ -387,8 +387,8 @@ params { } 'rn6' { fasta = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Annotation/Genes/genes.gtf" @@ -397,8 +397,8 @@ params { } 'sacCer3' { fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BismarkIndex/" readme = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Annotation/README.txt" @@ -407,8 +407,8 @@ params { } 'susScr3' { fasta = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/Bowtie2Index/" + bwa = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" + bowtie2 = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" star = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BismarkIndex/" gtf = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/Genes/genes.gtf" From d8ab22e58ee8e5e2dea1aef3a020671e9ba2b55e Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 24 Jul 2020 17:18:29 +0100 Subject: [PATCH 055/538] Change conda env path to explicit package name --- modules/local/process/bedtools_genomecov.nf | 2 +- modules/local/process/check_samplesheet.nf | 6 ++++++ modules/local/process/get_chrom_sizes.nf | 4 ++-- modules/local/process/get_software_versions.nf | 6 ++++++ modules/local/process/gtf2bed.nf | 2 +- modules/local/process/make_genome_filter.nf | 2 +- modules/nf-core/software/bwa_index.nf | 2 +- modules/nf-core/software/bwa_mem.nf | 2 +- modules/nf-core/software/deeptools_computematrix.nf | 2 +- modules/nf-core/software/deeptools_plotfingerprint.nf | 4 ++-- modules/nf-core/software/deeptools_plotheatmap.nf | 4 ++-- modules/nf-core/software/deeptools_plotprofile.nf | 4 ++-- modules/nf-core/software/fastqc.nf | 2 +- modules/nf-core/software/homer_annotatepeaks.nf | 4 ++-- modules/nf-core/software/macs2_callpeak.nf | 2 +- modules/nf-core/software/multiqc.nf | 4 ++-- modules/nf-core/software/phantompeakqualtools.nf | 4 ++-- modules/nf-core/software/picard_collectmultiplemetrics.nf | 2 +- modules/nf-core/software/picard_markduplicates.nf | 4 ++-- modules/nf-core/software/picard_mergesamfiles.nf | 4 ++-- modules/nf-core/software/preseq_lcextrap.nf | 2 +- modules/nf-core/software/samtools_flagstat.nf | 2 +- modules/nf-core/software/samtools_idxstats.nf | 4 ++-- modules/nf-core/software/samtools_index.nf | 4 ++-- modules/nf-core/software/samtools_sort.nf | 2 +- modules/nf-core/software/samtools_stats.nf | 4 ++-- modules/nf-core/software/subread_featurecounts.nf | 1 + modules/nf-core/software/trimgalore.nf | 2 +- modules/nf-core/software/ucsc_bedgraphtobigwig.nf | 2 +- 29 files changed, 51 insertions(+), 38 deletions(-) diff --git a/modules/local/process/bedtools_genomecov.nf b/modules/local/process/bedtools_genomecov.nf index 05611f55e..297faf6ad 100644 --- a/modules/local/process/bedtools_genomecov.nf +++ b/modules/local/process/bedtools_genomecov.nf @@ -11,7 +11,7 @@ process BEDTOOLS_GENOMECOV { container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" - conda (params.conda ? "${moduleDir}/environment.yml" : null) + conda (params.conda ? "bioconda::bedtools=2.29.2" : null) input: tuple val(meta), path(bam), path(flagstat) diff --git a/modules/local/process/check_samplesheet.nf b/modules/local/process/check_samplesheet.nf index 0a1f64c34..19c76dcb6 100755 --- a/modules/local/process/check_samplesheet.nf +++ b/modules/local/process/check_samplesheet.nf @@ -9,6 +9,12 @@ process CHECK_SAMPLESHEET { if (opts.publish_results == "none") null else filename } + // Re-use Python 3 in MultiQC container + container "quay.io/biocontainers/multiqc:1.9--pyh9f0ad1d_0" + //container "https://depot.galaxyproject.org/singularity/multiqc:1.9--pyh9f0ad1d_0" + + conda (params.conda ? "bioconda::multiqc=1.9" : null) + input: path samplesheet val opts diff --git a/modules/local/process/get_chrom_sizes.nf b/modules/local/process/get_chrom_sizes.nf index 79f6fa533..4f213d5fc 100644 --- a/modules/local/process/get_chrom_sizes.nf +++ b/modules/local/process/get_chrom_sizes.nf @@ -12,8 +12,8 @@ process GET_CHROM_SIZES { container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - //conda (params.conda ? "${moduleDir}/environment.yml" : null) - + conda (params.conda ? "bioconda::samtools=1.10" : null) + input: path fasta val opts diff --git a/modules/local/process/get_software_versions.nf b/modules/local/process/get_software_versions.nf index 0a90a0c62..be1631427 100755 --- a/modules/local/process/get_software_versions.nf +++ b/modules/local/process/get_software_versions.nf @@ -9,6 +9,12 @@ process GET_SOFTWARE_VERSIONS { else if (filename.endsWith('.yaml')) null else filename } + // Re-use Python 3 in MultiQC container + container "quay.io/biocontainers/multiqc:1.9--pyh9f0ad1d_0" + //container "https://depot.galaxyproject.org/singularity/multiqc:1.9--pyh9f0ad1d_0" + + conda (params.conda ? "bioconda::multiqc=1.9" : null) + input: val opts diff --git a/modules/local/process/gtf2bed.nf b/modules/local/process/gtf2bed.nf index 44ee3b098..008c781b6 100644 --- a/modules/local/process/gtf2bed.nf +++ b/modules/local/process/gtf2bed.nf @@ -13,7 +13,7 @@ process GTF2BED { container "quay.io/biocontainers/perl:5.26.2" //container "https://depot.galaxyproject.org/singularity/perl:5.26.2" - //conda (params.conda ? "${moduleDir}/environment.yml" : null) + conda (params.conda ? "conda-forge::perl=5.26.2" : null) input: path gtf diff --git a/modules/local/process/make_genome_filter.nf b/modules/local/process/make_genome_filter.nf index 8b2943c75..777c70afc 100644 --- a/modules/local/process/make_genome_filter.nf +++ b/modules/local/process/make_genome_filter.nf @@ -12,7 +12,7 @@ process MAKE_GENOME_FILTER { container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" - //conda (params.conda ? "${moduleDir}/environment.yml" : null) + conda (params.conda ? "bioconda::bedtools=2.29.2" : null) input: path sizes diff --git a/modules/nf-core/software/bwa_index.nf b/modules/nf-core/software/bwa_index.nf index 545748120..f6039ab45 100644 --- a/modules/nf-core/software/bwa_index.nf +++ b/modules/nf-core/software/bwa_index.nf @@ -11,7 +11,7 @@ process BWA_INDEX { container "biocontainers/bwa:v0.7.17_cv1" //container "https://depot.galaxyproject.org/singularity/bwa:0.7.17--hed695b0_7" - conda (params.conda ? "${moduleDir}/environment.yml" : null) + conda (params.conda ? "bioconda::bwa=0.7.17" : null) input: path fasta diff --git a/modules/nf-core/software/bwa_mem.nf b/modules/nf-core/software/bwa_mem.nf index cc751edd9..771a77163 100644 --- a/modules/nf-core/software/bwa_mem.nf +++ b/modules/nf-core/software/bwa_mem.nf @@ -11,7 +11,7 @@ process BWA_MEM { container "quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" //container "https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" - conda (params.conda ? "${moduleDir}/environment.yml" : null) + conda (params.conda ? "bioconda::bwa=0.7.17 bioconda::samtools=1.10" : null) input: tuple val(meta), path(reads) diff --git a/modules/nf-core/software/deeptools_computematrix.nf b/modules/nf-core/software/deeptools_computematrix.nf index 949c590f5..7b3ef284b 100644 --- a/modules/nf-core/software/deeptools_computematrix.nf +++ b/modules/nf-core/software/deeptools_computematrix.nf @@ -11,7 +11,7 @@ process DEEPTOOLS_COMPUTEMATRIX { container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" - conda (params.conda ? "${moduleDir}/environment.yml" : null) + conda (params.conda ? "bioconda::deeptools=3.4.3" : null) input: tuple val(meta), path(bigwig) diff --git a/modules/nf-core/software/deeptools_plotfingerprint.nf b/modules/nf-core/software/deeptools_plotfingerprint.nf index 99dbe26b9..bd8df5b21 100644 --- a/modules/nf-core/software/deeptools_plotfingerprint.nf +++ b/modules/nf-core/software/deeptools_plotfingerprint.nf @@ -11,8 +11,8 @@ process DEEPTOOLS_PLOTFINGERPRINT { container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" - conda (params.conda ? "${moduleDir}/environment.yml" : null) - + conda (params.conda ? "bioconda::deeptools=3.4.3" : null) + input: tuple val(meta), path(bams), path(bais) val opts diff --git a/modules/nf-core/software/deeptools_plotheatmap.nf b/modules/nf-core/software/deeptools_plotheatmap.nf index bdc3f500c..539195d76 100644 --- a/modules/nf-core/software/deeptools_plotheatmap.nf +++ b/modules/nf-core/software/deeptools_plotheatmap.nf @@ -11,8 +11,8 @@ process DEEPTOOLS_PLOTHEATMAP { container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" - conda (params.conda ? "${moduleDir}/environment.yml" : null) - + conda (params.conda ? "bioconda::deeptools=3.4.3" : null) + input: tuple val(meta), path(matrix) val opts diff --git a/modules/nf-core/software/deeptools_plotprofile.nf b/modules/nf-core/software/deeptools_plotprofile.nf index 96db40318..3de239dfb 100644 --- a/modules/nf-core/software/deeptools_plotprofile.nf +++ b/modules/nf-core/software/deeptools_plotprofile.nf @@ -11,8 +11,8 @@ process DEEPTOOLS_PLOTPROFILE { container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" - conda (params.conda ? "${moduleDir}/environment.yml" : null) - + conda (params.conda ? "bioconda::deeptools=3.4.3" : null) + input: tuple val(meta), path(matrix) val opts diff --git a/modules/nf-core/software/fastqc.nf b/modules/nf-core/software/fastqc.nf index 7c8967e7f..8bba91ef2 100755 --- a/modules/nf-core/software/fastqc.nf +++ b/modules/nf-core/software/fastqc.nf @@ -11,7 +11,7 @@ process FASTQC { container "quay.io/biocontainers/fastqc:0.11.9--0" //container "https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0" - conda (params.conda ? "${moduleDir}/environment.yml" : null) + conda (params.conda ? "bioconda::fastqc=0.11.9" : null) input: tuple val(meta), path(reads) diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf index 56189da48..2b501b555 100644 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ b/modules/nf-core/software/homer_annotatepeaks.nf @@ -11,8 +11,8 @@ process HOMER_ANNOTATEPEAKS { container "quay.io/biocontainers/homer:4.11--pl526h9a982cc_2" //container "https://depot.galaxyproject.org/singularity/homer:4.11--pl526h9a982cc_2" - conda (params.conda ? "${moduleDir}/environment.yml" : null) - + conda (params.conda ? "bioconda::homer=4.11" : null) + input: tuple val(meta), path(bed) path fasta diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf index fa6e16d3e..b7536f06b 100644 --- a/modules/nf-core/software/macs2_callpeak.nf +++ b/modules/nf-core/software/macs2_callpeak.nf @@ -1,7 +1,7 @@ container "quay.io/biocontainers/macs2:2.2.7.1--py37h516909a_0" //container "https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py37h516909a_0" //echo \$(macs2 --version 2>&1) > macs2.version.txt - +conda (params.conda ? "bioconda::macs2=2.2.7.1" : null) // /* // * STEP 6.2: Call peaks with MACS2 and calculate FRiP score diff --git a/modules/nf-core/software/multiqc.nf b/modules/nf-core/software/multiqc.nf index 08da39c29..8ec114575 100755 --- a/modules/nf-core/software/multiqc.nf +++ b/modules/nf-core/software/multiqc.nf @@ -30,8 +30,8 @@ process MULTIQC { container "quay.io/biocontainers/multiqc:1.9--pyh9f0ad1d_0" //container "https://depot.galaxyproject.org/singularity/multiqc:1.9--pyh9f0ad1d_0" - conda (params.conda ? "${moduleDir}/environment.yml" : null) - + conda (params.conda ? "bioconda::multiqc=1.9" : null) + input: path (multiqc_config) from ch_multiqc_config path (mqc_custom_config) from ch_multiqc_custom_config.collect().ifEmpty([]) diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf index 95b95ea97..7664ff164 100644 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ b/modules/nf-core/software/phantompeakqualtools.nf @@ -11,8 +11,8 @@ process PHANTOMPEAKQUALTOOLS { container "quay.io/biocontainers/phantompeakqualtools:1.2.2--0" //container "https://depot.galaxyproject.org/singularity/phantompeakqualtools:1.2.2--0" - conda (params.conda ? "${moduleDir}/environment.yml" : null) - + conda (params.conda ? "bioconda::phantompeakqualtools=1.2.2" : null) + input: tuple val(meta), path(bam) val opts diff --git a/modules/nf-core/software/picard_collectmultiplemetrics.nf b/modules/nf-core/software/picard_collectmultiplemetrics.nf index fa3304f7c..aaaea4d63 100644 --- a/modules/nf-core/software/picard_collectmultiplemetrics.nf +++ b/modules/nf-core/software/picard_collectmultiplemetrics.nf @@ -11,7 +11,7 @@ process PICARD_COLLECTMULTIPLEMETRICS { container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" - conda (params.conda ? "${moduleDir}/environment.yml" : null) + conda (params.conda ? "bioconda::picard=2.23.2" : null) input: tuple val(meta), path(bam) diff --git a/modules/nf-core/software/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf index 785e4f769..73ab8f0ac 100644 --- a/modules/nf-core/software/picard_markduplicates.nf +++ b/modules/nf-core/software/picard_markduplicates.nf @@ -11,8 +11,8 @@ process PICARD_MARKDUPLICATES { container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" - conda (params.conda ? "${moduleDir}/environment.yml" : null) - + conda (params.conda ? "bioconda::picard=2.23.2" : null) + input: tuple val(meta), path(bam) val opts diff --git a/modules/nf-core/software/picard_mergesamfiles.nf b/modules/nf-core/software/picard_mergesamfiles.nf index b732f7f6b..19a7d8d6f 100644 --- a/modules/nf-core/software/picard_mergesamfiles.nf +++ b/modules/nf-core/software/picard_mergesamfiles.nf @@ -11,8 +11,8 @@ process PICARD_MERGESAMFILES { container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" - conda (params.conda ? "${moduleDir}/environment.yml" : null) - + conda (params.conda ? "bioconda::picard=2.23.2" : null) + input: tuple val(meta), path(bams) val opts diff --git a/modules/nf-core/software/preseq_lcextrap.nf b/modules/nf-core/software/preseq_lcextrap.nf index 24af85664..6ba2a7a7e 100644 --- a/modules/nf-core/software/preseq_lcextrap.nf +++ b/modules/nf-core/software/preseq_lcextrap.nf @@ -12,7 +12,7 @@ process PRESEQ_LCEXTRAP { container "quay.io/biocontainers/preseq:2.0.3--hf53bd2b_3" //container "https://depot.galaxyproject.org/singularity/preseq:2.0.3--hf53bd2b_3" - conda (params.conda ? "${moduleDir}/environment.yml" : null) + conda (params.conda ? "bioconda::preseq=2.0.3" : null) input: tuple val(meta), path(bam) diff --git a/modules/nf-core/software/samtools_flagstat.nf b/modules/nf-core/software/samtools_flagstat.nf index eb5b910dc..e641c5b0e 100644 --- a/modules/nf-core/software/samtools_flagstat.nf +++ b/modules/nf-core/software/samtools_flagstat.nf @@ -10,7 +10,7 @@ process SAMTOOLS_FLAGSTAT { container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - conda (params.conda ? "${moduleDir}/environment.yml" : null) + conda (params.conda ? "bioconda::samtools=1.10" : null) input: tuple val(meta), path(bam), path(bai) diff --git a/modules/nf-core/software/samtools_idxstats.nf b/modules/nf-core/software/samtools_idxstats.nf index fd1eac27b..cacd23baa 100644 --- a/modules/nf-core/software/samtools_idxstats.nf +++ b/modules/nf-core/software/samtools_idxstats.nf @@ -10,8 +10,8 @@ process SAMTOOLS_IDXSTATS { container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - conda (params.conda ? "${moduleDir}/environment.yml" : null) - + conda (params.conda ? "bioconda::samtools=1.10" : null) + input: tuple val(meta), path(bam), path(bai) val opts diff --git a/modules/nf-core/software/samtools_index.nf b/modules/nf-core/software/samtools_index.nf index 204289fa8..1a99fcaca 100644 --- a/modules/nf-core/software/samtools_index.nf +++ b/modules/nf-core/software/samtools_index.nf @@ -10,8 +10,8 @@ process SAMTOOLS_INDEX { container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - conda (params.conda ? "${moduleDir}/environment.yml" : null) - + conda (params.conda ? "bioconda::samtools=1.10" : null) + input: tuple val(meta), path(bam) val opts diff --git a/modules/nf-core/software/samtools_sort.nf b/modules/nf-core/software/samtools_sort.nf index c309a2af7..a3532a5b7 100644 --- a/modules/nf-core/software/samtools_sort.nf +++ b/modules/nf-core/software/samtools_sort.nf @@ -11,7 +11,7 @@ process SAMTOOLS_SORT { container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - conda (params.conda ? "${moduleDir}/environment.yml" : null) + conda (params.conda ? "bioconda::samtools=1.10" : null) input: tuple val(meta), path(bam) diff --git a/modules/nf-core/software/samtools_stats.nf b/modules/nf-core/software/samtools_stats.nf index c568740df..7a0d68c26 100644 --- a/modules/nf-core/software/samtools_stats.nf +++ b/modules/nf-core/software/samtools_stats.nf @@ -10,8 +10,8 @@ process SAMTOOLS_STATS { container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - conda (params.conda ? "${moduleDir}/environment.yml" : null) - + conda (params.conda ? "bioconda::samtools=1.10" : null) + input: tuple val(meta), path(bam), path(bai) val opts diff --git a/modules/nf-core/software/subread_featurecounts.nf b/modules/nf-core/software/subread_featurecounts.nf index 54771185a..c50b2bc79 100644 --- a/modules/nf-core/software/subread_featurecounts.nf +++ b/modules/nf-core/software/subread_featurecounts.nf @@ -1,6 +1,7 @@ container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" //container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" //echo \$(featureCounts -v 2>&1) > featurecounts.version.txt +conda (params.conda ? "bioconda::subread=2.0.1" : null) // /* // * STEP 7.3: Count reads in consensus peaks with featureCounts diff --git a/modules/nf-core/software/trimgalore.nf b/modules/nf-core/software/trimgalore.nf index eaecdf8fe..1dcef6bd7 100644 --- a/modules/nf-core/software/trimgalore.nf +++ b/modules/nf-core/software/trimgalore.nf @@ -11,7 +11,7 @@ process TRIMGALORE { container "quay.io/biocontainers/trim-galore:0.6.5--0" //container "https://depot.galaxyproject.org/singularity/trim-galore:0.6.5--0" - conda (params.conda ? "${moduleDir}/environment.yml" : null) + conda (params.conda ? "bioconda::trim-galore=0.6.5" : null) input: tuple val(meta), path(reads) diff --git a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf index 7e93d36cc..176b6b237 100644 --- a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf +++ b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf @@ -11,7 +11,7 @@ process UCSC_BEDRAPHTOBIGWIG { container "quay.io/biocontainers/ucsc-bedgraphtobigwig:377--h446ed27_1" //container "https://depot.galaxyproject.org/singularity/ucsc-bedgraphtobigwig:377--h446ed27_1" - conda (params.conda ? "${moduleDir}/environment.yml" : null) + conda (params.conda ? "bioconda::ucsc-bedgraphtobigwig=377" : null) input: tuple val(meta), path(bedgraph) From eb1c4b58d216c96c4791ea6804dd28038556e916 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 24 Jul 2020 18:52:23 +0100 Subject: [PATCH 056/538] Use first ever stable DSL2 release! Wooooohhooooooo --- .github/workflows/ci.yml | 4 ++-- CHANGELOG.md | 2 +- README.md | 2 +- nextflow.config | 2 +- 4 files changed, 5 insertions(+), 5 deletions(-) diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index aaed40ac2..1440d45b7 100755 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -21,7 +21,7 @@ jobs: strategy: matrix: # Nextflow versions: check pipeline minimum and current latest - nxf_ver: ['20.04.1', ''] + nxf_ver: ['20.07.1', ''] steps: - name: Check out pipeline code uses: actions/checkout@v2 @@ -57,7 +57,7 @@ jobs: if: ${{ github.event_name != 'push' || (github.event_name == 'push' && github.repository == 'nf-core/chipseq') }} runs-on: ubuntu-latest env: - NXF_VER: '20.04.1' + NXF_VER: '20.07.1' NXF_ANSI_LOG: false strategy: matrix: diff --git a/CHANGELOG.md b/CHANGELOG.md index 4d3d088e8..37994ed80 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -14,7 +14,7 @@ and this project adheres to [Semantic Versioning](http://semver.org/spec/v2.0.0. ### `Dependencies` -* Update Nextflow `19.10.0` -> `20.04.1` +* Update Nextflow `19.10.0` -> `20.07.1` ## [1.2.0] - 2020-07-02 diff --git a/README.md b/README.md index 58ab48a8b..71db377df 100644 --- a/README.md +++ b/README.md @@ -2,7 +2,7 @@ [![GitHub Actions CI Status](https://github.com/nf-core/chipseq/workflows/nf-core%20CI/badge.svg)](https://github.com/nf-core/chipseq/actions) [![GitHub Actions Linting Status](https://github.com/nf-core/chipseq/workflows/nf-core%20linting/badge.svg)](https://github.com/nf-core/chipseq/actions) -[![Nextflow](https://img.shields.io/badge/nextflow-%E2%89%A520.04.1-brightgreen.svg)](https://www.nextflow.io/) +[![Nextflow](https://img.shields.io/badge/nextflow-%E2%89%A520.07.1-brightgreen.svg)](https://www.nextflow.io/) [![DOI](https://zenodo.org/badge/DOI/10.5281/zenodo.3240506.svg)](https://doi.org/10.5281/zenodo.3240506) [![install with bioconda](https://img.shields.io/badge/install%20with-bioconda-brightgreen.svg)](http://bioconda.github.io/) diff --git a/nextflow.config b/nextflow.config index 28e37f721..d88f36478 100644 --- a/nextflow.config +++ b/nextflow.config @@ -171,7 +171,7 @@ manifest { homePage = 'https://github.com/nf-core/chipseq' description = 'ChIP-seq peak-calling and differential analysis pipeline.' mainScript = 'main.nf' - nextflowVersion = '>=20.04.1' + nextflowVersion = '>=20.07.1' version = '1.3.0dev' } From f6fddafd112d3e7d8c5101facf3fd4cce83e64fe Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 24 Jul 2020 18:55:05 +0100 Subject: [PATCH 057/538] enable DLS2 instead of previewing it. Duh. --- main.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/main.nf b/main.nf index bff23dbe9..3db120b0d 100755 --- a/main.nf +++ b/main.nf @@ -9,7 +9,7 @@ ---------------------------------------------------------------------------------------- */ -nextflow.preview.dsl = 2 +nextflow.enable.dsl = 2 /* * Print help message if required From fed4aab2b05591fd9c8884d909ab306227e86e3a Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 24 Jul 2020 18:57:12 +0100 Subject: [PATCH 058/538] Remove container definition --- modules/local/process/get_software_versions.nf | 6 ------ 1 file changed, 6 deletions(-) diff --git a/modules/local/process/get_software_versions.nf b/modules/local/process/get_software_versions.nf index be1631427..0a90a0c62 100755 --- a/modules/local/process/get_software_versions.nf +++ b/modules/local/process/get_software_versions.nf @@ -9,12 +9,6 @@ process GET_SOFTWARE_VERSIONS { else if (filename.endsWith('.yaml')) null else filename } - // Re-use Python 3 in MultiQC container - container "quay.io/biocontainers/multiqc:1.9--pyh9f0ad1d_0" - //container "https://depot.galaxyproject.org/singularity/multiqc:1.9--pyh9f0ad1d_0" - - conda (params.conda ? "bioconda::multiqc=1.9" : null) - input: val opts From 7296a9c9f67d1068a1ad83675092b9a74e6b2ffb Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 24 Jul 2020 19:25:48 +0100 Subject: [PATCH 059/538] Remove redundant packages --- environment.yml | 14 -------------- 1 file changed, 14 deletions(-) diff --git a/environment.yml b/environment.yml index 7beb5868a..ba6cbcd12 100644 --- a/environment.yml +++ b/environment.yml @@ -22,26 +22,12 @@ dependencies: - conda-forge::r-lattice=0.20_41 - conda-forge::r-upsetr=1.4.0 - conda-forge::r-xfun=0.15 - #- conda-forge::gawk=5.1.0 - #- conda-forge::pigz=2.3.4 ## Required for TrimGalore multi-threading ## bioconda packages - #- bioconda::fastqc=0.11.9 - #- bioconda::trim-galore=0.6.5 - #- bioconda::bwa=0.7.17 - bioconda::samtools=1.10 - #- bioconda::picard=2.23.1 - bioconda::bamtools=2.5.1 - bioconda::pysam=0.15.3 - bioconda::bedtools=2.29.2 - #- bioconda::ucsc-bedgraphtobigwig=357 - #- bioconda::deeptools=3.4.3 - #- bioconda::macs2=2.2.7.1 - #- bioconda::homer=4.11 - #- bioconda::subread=2.0.1 - #- bioconda::phantompeakqualtools=1.2.2 - #- bioconda::preseq=2.0.3 - #- bioconda::multiqc=1.9 - bioconda::bioconductor-biocparallel=1.20.0 - bioconda::bioconductor-deseq2=1.26.0 - bioconda::bioconductor-vsn=3.54.0 From f35f1bb318f30661cd742f07a3f1bc7ba0d932ca Mon Sep 17 00:00:00 2001 From: drpatelh Date: Sat, 25 Jul 2020 06:55:02 +0100 Subject: [PATCH 060/538] Comment out get software versions for now --- main.nf | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/main.nf b/main.nf index 3db120b0d..5e0950a7f 100755 --- a/main.nf +++ b/main.nf @@ -331,9 +331,9 @@ workflow { /* * Pipeline reporting */ - GET_SOFTWARE_VERSIONS ( - params.modules['get_software_versions'] - ) + //GET_SOFTWARE_VERSIONS ( + // params.modules['get_software_versions'] + //) OUTPUT_DOCUMENTATION ( ch_output_docs, From 0bf0cdee153b58ab1b73d9cb0379e9941e9523a3 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Sat, 25 Jul 2020 07:54:02 +0100 Subject: [PATCH 061/538] Get --conda working for pipeline --- environment.yml | 14 +++++++------- modules/local/process/bedtools_genomecov.nf | 5 +---- modules/local/process/calc_frip.nf | 1 + modules/local/process/check_samplesheet.nf | 6 +----- modules/local/process/featurecounts_deseq2.nf | 2 +- modules/local/process/filter_bam.nf | 2 ++ modules/local/process/get_chrom_sizes.nf | 5 +---- modules/local/process/gtf2bed.nf | 5 +---- modules/local/process/igv.nf | 1 + modules/local/process/macs2_consensus.nf | 1 + modules/local/process/make_genome_filter.nf | 5 +---- modules/local/process/output_documentation.nf | 2 ++ modules/local/process/plot_homer_annotatepeaks.nf | 1 + modules/local/process/remove_bam_orphans.nf | 2 ++ modules/nf-core/software/phantompeakqualtools.nf | 3 +-- nextflow.config | 1 + 16 files changed, 25 insertions(+), 31 deletions(-) diff --git a/environment.yml b/environment.yml index ba6cbcd12..361352d0c 100644 --- a/environment.yml +++ b/environment.yml @@ -7,11 +7,11 @@ channels: - defaults dependencies: ## conda-forge packages - - conda-forge::python=3.7.6 + - conda-forge::python=3.7.8 - conda-forge::markdown=3.2.2 - conda-forge::pymdown-extensions=7.1 - conda-forge::pygments=2.6.1 - - conda-forge::r-base=3.6.2 + - conda-forge::r-base=4.0.2 - conda-forge::r-optparse=1.6.6 - conda-forge::r-rcolorbrewer=1.1_2 - conda-forge::r-reshape2=1.4.4 @@ -21,13 +21,13 @@ dependencies: - conda-forge::r-pheatmap=1.0.12 - conda-forge::r-lattice=0.20_41 - conda-forge::r-upsetr=1.4.0 - - conda-forge::r-xfun=0.15 + - conda-forge::r-xfun=0.16 ## bioconda packages - bioconda::samtools=1.10 - bioconda::bamtools=2.5.1 - - bioconda::pysam=0.15.3 + - bioconda::pysam=0.16.0.1 - bioconda::bedtools=2.29.2 - - bioconda::bioconductor-biocparallel=1.20.0 - - bioconda::bioconductor-deseq2=1.26.0 - - bioconda::bioconductor-vsn=3.54.0 + - bioconda::bioconductor-biocparallel=1.22.0 + - bioconda::bioconductor-deseq2=1.28.0 + - bioconda::bioconductor-vsn=3.56.0 diff --git a/modules/local/process/bedtools_genomecov.nf b/modules/local/process/bedtools_genomecov.nf index 297faf6ad..290f64aa7 100644 --- a/modules/local/process/bedtools_genomecov.nf +++ b/modules/local/process/bedtools_genomecov.nf @@ -8,10 +8,7 @@ process BEDTOOLS_GENOMECOV { else if (filename.endsWith('.version.txt')) null else filename } - container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" - //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" - - conda (params.conda ? "bioconda::bedtools=2.29.2" : null) + conda (params.conda ? "${baseDir}/environment.yml" : null) input: tuple val(meta), path(bam), path(flagstat) diff --git a/modules/local/process/calc_frip.nf b/modules/local/process/calc_frip.nf index e69de29bb..a90c447d1 100644 --- a/modules/local/process/calc_frip.nf +++ b/modules/local/process/calc_frip.nf @@ -0,0 +1 @@ +conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/check_samplesheet.nf b/modules/local/process/check_samplesheet.nf index 19c76dcb6..79357dee2 100755 --- a/modules/local/process/check_samplesheet.nf +++ b/modules/local/process/check_samplesheet.nf @@ -9,11 +9,7 @@ process CHECK_SAMPLESHEET { if (opts.publish_results == "none") null else filename } - // Re-use Python 3 in MultiQC container - container "quay.io/biocontainers/multiqc:1.9--pyh9f0ad1d_0" - //container "https://depot.galaxyproject.org/singularity/multiqc:1.9--pyh9f0ad1d_0" - - conda (params.conda ? "bioconda::multiqc=1.9" : null) + conda (params.conda ? "${baseDir}/environment.yml" : null) input: path samplesheet diff --git a/modules/local/process/featurecounts_deseq2.nf b/modules/local/process/featurecounts_deseq2.nf index fb1e28240..4586ee7e1 100644 --- a/modules/local/process/featurecounts_deseq2.nf +++ b/modules/local/process/featurecounts_deseq2.nf @@ -1,4 +1,4 @@ - +conda (params.conda ? "${baseDir}/environment.yml" : null) // /* // * STEP 7.4: Differential analysis with DESeq2 diff --git a/modules/local/process/filter_bam.nf b/modules/local/process/filter_bam.nf index 32c9f8f02..f3e215889 100644 --- a/modules/local/process/filter_bam.nf +++ b/modules/local/process/filter_bam.nf @@ -11,6 +11,8 @@ process FILTER_BAM { else if (filename.endsWith('.version.txt')) null else filename } + conda (params.conda ? "${baseDir}/environment.yml" : null) + input: tuple val(meta), path(bam), path(bai) path bed diff --git a/modules/local/process/get_chrom_sizes.nf b/modules/local/process/get_chrom_sizes.nf index 4f213d5fc..3dfed0f80 100644 --- a/modules/local/process/get_chrom_sizes.nf +++ b/modules/local/process/get_chrom_sizes.nf @@ -9,10 +9,7 @@ process GET_CHROM_SIZES { if (opts.publish_results == "none") null else filename } - container "quay.io/biocontainers/samtools:1.10--h9402c20_2" - //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - - conda (params.conda ? "bioconda::samtools=1.10" : null) + conda (params.conda ? "${baseDir}/environment.yml" : null) input: path fasta diff --git a/modules/local/process/gtf2bed.nf b/modules/local/process/gtf2bed.nf index 008c781b6..43536aa26 100644 --- a/modules/local/process/gtf2bed.nf +++ b/modules/local/process/gtf2bed.nf @@ -10,10 +10,7 @@ process GTF2BED { if (opts.publish_results == "none") null else filename } - container "quay.io/biocontainers/perl:5.26.2" - //container "https://depot.galaxyproject.org/singularity/perl:5.26.2" - - conda (params.conda ? "conda-forge::perl=5.26.2" : null) + conda (params.conda ? "${baseDir}/environment.yml" : null) input: path gtf diff --git a/modules/local/process/igv.nf b/modules/local/process/igv.nf index cc7a9c228..e1d94bbfb 100644 --- a/modules/local/process/igv.nf +++ b/modules/local/process/igv.nf @@ -1,3 +1,4 @@ +//conda (params.conda ? "${baseDir}/environment.yml" : null) // /* // * STEP 8: Create IGV session file // */ diff --git a/modules/local/process/macs2_consensus.nf b/modules/local/process/macs2_consensus.nf index b36d6a197..134a9857f 100644 --- a/modules/local/process/macs2_consensus.nf +++ b/modules/local/process/macs2_consensus.nf @@ -1,3 +1,4 @@ +// conda (params.conda ? "${baseDir}/environment.yml" : null) // /* // * STEP 7.1: Consensus peaks across samples, create boolean filtering file, SAF file for featureCounts and UpSetR plot for intersection // */ diff --git a/modules/local/process/make_genome_filter.nf b/modules/local/process/make_genome_filter.nf index 777c70afc..7341751a8 100644 --- a/modules/local/process/make_genome_filter.nf +++ b/modules/local/process/make_genome_filter.nf @@ -9,10 +9,7 @@ process MAKE_GENOME_FILTER { if (opts.publish_results == "none") null else filename } - container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" - //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" - - conda (params.conda ? "bioconda::bedtools=2.29.2" : null) + conda (params.conda ? "${baseDir}/environment.yml" : null) input: path sizes diff --git a/modules/local/process/output_documentation.nf b/modules/local/process/output_documentation.nf index e3201527a..831760931 100755 --- a/modules/local/process/output_documentation.nf +++ b/modules/local/process/output_documentation.nf @@ -8,6 +8,8 @@ process OUTPUT_DOCUMENTATION { if (opts.publish_results == "none") null else filename } + conda (params.conda ? "${baseDir}/environment.yml" : null) + input: path output_docs path images diff --git a/modules/local/process/plot_homer_annotatepeaks.nf b/modules/local/process/plot_homer_annotatepeaks.nf index 477c84845..87099c1a3 100644 --- a/modules/local/process/plot_homer_annotatepeaks.nf +++ b/modules/local/process/plot_homer_annotatepeaks.nf @@ -1,3 +1,4 @@ +conda (params.conda ? "${baseDir}/environment.yml" : null) // /* // * STEP 6.4: Aggregated QC plots for peaks, FRiP and peak-to-gene annotation // */ diff --git a/modules/local/process/remove_bam_orphans.nf b/modules/local/process/remove_bam_orphans.nf index 46fbc30c9..83c3f654b 100644 --- a/modules/local/process/remove_bam_orphans.nf +++ b/modules/local/process/remove_bam_orphans.nf @@ -10,6 +10,8 @@ process REMOVE_BAM_ORPHANS { if (opts.publish_results == "none") null else filename } + conda (params.conda ? "${baseDir}/environment.yml" : null) + input: tuple val(meta), path(bam) val opts diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf index 7664ff164..cbf1541a3 100644 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ b/modules/nf-core/software/phantompeakqualtools.nf @@ -25,8 +25,7 @@ process PHANTOMPEAKQUALTOOLS { script: prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" """ - RUN_SPP=`which run_spp.R` - Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus + Rscript -e "library(caTools); source(run_spp.R)" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus Rscript -e "load('${prefix}.spp.Rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}_spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" touch phantompeakqualtools.version.txt diff --git a/nextflow.config b/nextflow.config index d88f36478..fe2bcc264 100644 --- a/nextflow.config +++ b/nextflow.config @@ -72,6 +72,7 @@ params { config_profile_url = false // Options: Other + conda = false help = false outdir = './results' publish_dir_mode = 'copy' From 459ba76dcb656f5278a105fa19f55b76b58af9c0 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Sat, 25 Jul 2020 08:13:45 +0100 Subject: [PATCH 062/538] Bad Conda, bad Conda --- modules/nf-core/software/phantompeakqualtools.nf | 5 +++-- 1 file changed, 3 insertions(+), 2 deletions(-) diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf index cbf1541a3..ba2b6dd12 100644 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ b/modules/nf-core/software/phantompeakqualtools.nf @@ -12,7 +12,7 @@ process PHANTOMPEAKQUALTOOLS { //container "https://depot.galaxyproject.org/singularity/phantompeakqualtools:1.2.2--0" conda (params.conda ? "bioconda::phantompeakqualtools=1.2.2" : null) - + input: tuple val(meta), path(bam) val opts @@ -25,7 +25,8 @@ process PHANTOMPEAKQUALTOOLS { script: prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" """ - Rscript -e "library(caTools); source(run_spp.R)" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus + RUN_SPP=`which run_spp.R` + Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus Rscript -e "load('${prefix}.spp.Rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}_spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" touch phantompeakqualtools.version.txt From 3dfb7ad7ecc2d72aa20cb9eb1bcc9fbade33dd48 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Sat, 25 Jul 2020 11:51:14 +0100 Subject: [PATCH 063/538] Fix indents --- modules/local/process/bedtools_genomecov.nf | 6 +-- modules/local/process/check_samplesheet.nf | 4 +- modules/local/process/filter_bam.nf | 6 +-- modules/local/process/get_chrom_sizes.nf | 4 +- .../local/process/get_software_versions.nf | 6 +-- modules/local/process/gtf2bed.nf | 4 +- modules/local/process/make_genome_filter.nf | 4 +- modules/local/process/output_documentation.nf | 4 +- modules/local/process/remove_bam_orphans.nf | 4 +- modules/nf-core/software/bwa_index.nf | 6 +-- modules/nf-core/software/bwa_mem.nf | 6 +-- .../software/deeptools_computematrix.nf | 6 +-- .../software/deeptools_plotfingerprint.nf | 6 +-- .../nf-core/software/deeptools_plotheatmap.nf | 6 +-- .../nf-core/software/deeptools_plotprofile.nf | 6 +-- modules/nf-core/software/fastqc.nf | 6 +-- .../nf-core/software/homer_annotatepeaks.nf | 8 ++-- modules/nf-core/software/macs2_callpeak.nf | 43 +++++++++++++++++++ .../nf-core/software/phantompeakqualtools.nf | 6 +-- .../software/picard_collectmultiplemetrics.nf | 6 +-- .../nf-core/software/picard_markduplicates.nf | 6 +-- .../nf-core/software/picard_mergesamfiles.nf | 6 +-- modules/nf-core/software/preseq_lcextrap.nf | 6 +-- modules/nf-core/software/samtools_flagstat.nf | 6 +-- modules/nf-core/software/samtools_idxstats.nf | 6 +-- modules/nf-core/software/samtools_index.nf | 6 +-- modules/nf-core/software/samtools_sort.nf | 6 +-- modules/nf-core/software/samtools_stats.nf | 6 +-- modules/nf-core/software/trimgalore.nf | 6 +-- .../nf-core/software/ucsc_bedgraphtobigwig.nf | 6 +-- 30 files changed, 125 insertions(+), 82 deletions(-) diff --git a/modules/local/process/bedtools_genomecov.nf b/modules/local/process/bedtools_genomecov.nf index 290f64aa7..7b0860ba1 100644 --- a/modules/local/process/bedtools_genomecov.nf +++ b/modules/local/process/bedtools_genomecov.nf @@ -4,9 +4,9 @@ process BEDTOOLS_GENOMECOV { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/check_samplesheet.nf b/modules/local/process/check_samplesheet.nf index 79357dee2..757453eb3 100755 --- a/modules/local/process/check_samplesheet.nf +++ b/modules/local/process/check_samplesheet.nf @@ -6,8 +6,8 @@ process CHECK_SAMPLESHEET { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else filename } + if (opts.publish_results == "none") null + else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/filter_bam.nf b/modules/local/process/filter_bam.nf index f3e215889..6302d858e 100644 --- a/modules/local/process/filter_bam.nf +++ b/modules/local/process/filter_bam.nf @@ -7,9 +7,9 @@ process FILTER_BAM { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/get_chrom_sizes.nf b/modules/local/process/get_chrom_sizes.nf index 3dfed0f80..6051b4dfd 100644 --- a/modules/local/process/get_chrom_sizes.nf +++ b/modules/local/process/get_chrom_sizes.nf @@ -6,8 +6,8 @@ process GET_CHROM_SIZES { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else filename } + if (opts.publish_results == "none") null + else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/get_software_versions.nf b/modules/local/process/get_software_versions.nf index 0a90a0c62..c946bafc0 100755 --- a/modules/local/process/get_software_versions.nf +++ b/modules/local/process/get_software_versions.nf @@ -5,9 +5,9 @@ process GET_SOFTWARE_VERSIONS { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.yaml')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.yaml')) null + else filename } input: val opts diff --git a/modules/local/process/gtf2bed.nf b/modules/local/process/gtf2bed.nf index 43536aa26..bcc2848e2 100644 --- a/modules/local/process/gtf2bed.nf +++ b/modules/local/process/gtf2bed.nf @@ -7,8 +7,8 @@ process GTF2BED { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else filename } + if (opts.publish_results == "none") null + else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/make_genome_filter.nf b/modules/local/process/make_genome_filter.nf index 7341751a8..542d566c5 100644 --- a/modules/local/process/make_genome_filter.nf +++ b/modules/local/process/make_genome_filter.nf @@ -6,8 +6,8 @@ process MAKE_GENOME_FILTER { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else filename } + if (opts.publish_results == "none") null + else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/output_documentation.nf b/modules/local/process/output_documentation.nf index 831760931..39332b811 100755 --- a/modules/local/process/output_documentation.nf +++ b/modules/local/process/output_documentation.nf @@ -5,8 +5,8 @@ process OUTPUT_DOCUMENTATION { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else filename } + if (opts.publish_results == "none") null + else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/remove_bam_orphans.nf b/modules/local/process/remove_bam_orphans.nf index 83c3f654b..52a6ade92 100644 --- a/modules/local/process/remove_bam_orphans.nf +++ b/modules/local/process/remove_bam_orphans.nf @@ -7,8 +7,8 @@ process REMOVE_BAM_ORPHANS { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else filename } + if (opts.publish_results == "none") null + else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/nf-core/software/bwa_index.nf b/modules/nf-core/software/bwa_index.nf index f6039ab45..775e0254b 100644 --- a/modules/nf-core/software/bwa_index.nf +++ b/modules/nf-core/software/bwa_index.nf @@ -4,9 +4,9 @@ process BWA_INDEX { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "biocontainers/bwa:v0.7.17_cv1" //container "https://depot.galaxyproject.org/singularity/bwa:0.7.17--hed695b0_7" diff --git a/modules/nf-core/software/bwa_mem.nf b/modules/nf-core/software/bwa_mem.nf index 771a77163..ff8657c88 100644 --- a/modules/nf-core/software/bwa_mem.nf +++ b/modules/nf-core/software/bwa_mem.nf @@ -4,9 +4,9 @@ process BWA_MEM { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" //container "https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" diff --git a/modules/nf-core/software/deeptools_computematrix.nf b/modules/nf-core/software/deeptools_computematrix.nf index 7b3ef284b..7d597f69b 100644 --- a/modules/nf-core/software/deeptools_computematrix.nf +++ b/modules/nf-core/software/deeptools_computematrix.nf @@ -4,9 +4,9 @@ process DEEPTOOLS_COMPUTEMATRIX { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" diff --git a/modules/nf-core/software/deeptools_plotfingerprint.nf b/modules/nf-core/software/deeptools_plotfingerprint.nf index bd8df5b21..dec02162d 100644 --- a/modules/nf-core/software/deeptools_plotfingerprint.nf +++ b/modules/nf-core/software/deeptools_plotfingerprint.nf @@ -4,9 +4,9 @@ process DEEPTOOLS_PLOTFINGERPRINT { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" diff --git a/modules/nf-core/software/deeptools_plotheatmap.nf b/modules/nf-core/software/deeptools_plotheatmap.nf index 539195d76..501fa106a 100644 --- a/modules/nf-core/software/deeptools_plotheatmap.nf +++ b/modules/nf-core/software/deeptools_plotheatmap.nf @@ -4,9 +4,9 @@ process DEEPTOOLS_PLOTHEATMAP { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" diff --git a/modules/nf-core/software/deeptools_plotprofile.nf b/modules/nf-core/software/deeptools_plotprofile.nf index 3de239dfb..35ee9b2ec 100644 --- a/modules/nf-core/software/deeptools_plotprofile.nf +++ b/modules/nf-core/software/deeptools_plotprofile.nf @@ -4,9 +4,9 @@ process DEEPTOOLS_PLOTPROFILE { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" diff --git a/modules/nf-core/software/fastqc.nf b/modules/nf-core/software/fastqc.nf index 8bba91ef2..c6adb0693 100755 --- a/modules/nf-core/software/fastqc.nf +++ b/modules/nf-core/software/fastqc.nf @@ -4,9 +4,9 @@ process FASTQC { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/fastqc:0.11.9--0" //container "https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0" diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf index 2b501b555..c45b7383f 100644 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ b/modules/nf-core/software/homer_annotatepeaks.nf @@ -4,15 +4,15 @@ process HOMER_ANNOTATEPEAKS { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/homer:4.11--pl526h9a982cc_2" //container "https://depot.galaxyproject.org/singularity/homer:4.11--pl526h9a982cc_2" conda (params.conda ? "bioconda::homer=4.11" : null) - + input: tuple val(meta), path(bed) path fasta diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf index b7536f06b..67b4e84ad 100644 --- a/modules/nf-core/software/macs2_callpeak.nf +++ b/modules/nf-core/software/macs2_callpeak.nf @@ -3,6 +3,49 @@ container "quay.io/biocontainers/macs2:2.2.7.1--py37h516909a_0" //echo \$(macs2 --version 2>&1) > macs2.version.txt conda (params.conda ? "bioconda::macs2=2.2.7.1" : null) +process MACS2_CALLPEAK { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/homer:4.11--pl526h9a982cc_2" + //container "https://depot.galaxyproject.org/singularity/homer:4.11--pl526h9a982cc_2" + + conda (params.conda ? "bioconda::homer=4.11" : null) + + input: + tuple val(meta), path(bed) + path fasta + path gtf + val opts + + output: + tuple val(meta), path("*.txt"), emit: txt + path "*.version.txt", emit: version + + script: + prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + + """ + annotatePeaks.pl \\ + $opts.args \\ + $bed \\ + $fasta \\ + -gtf $gtf \\ + -cpu $task.cpus \\ + > ${prefix}.annotatePeaks.txt + + touch homer.version.txt + """ +} + + + // /* // * STEP 6.2: Call peaks with MACS2 and calculate FRiP score // */ diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf index ba2b6dd12..44db1529c 100644 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ b/modules/nf-core/software/phantompeakqualtools.nf @@ -4,9 +4,9 @@ process PHANTOMPEAKQUALTOOLS { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/phantompeakqualtools:1.2.2--0" //container "https://depot.galaxyproject.org/singularity/phantompeakqualtools:1.2.2--0" diff --git a/modules/nf-core/software/picard_collectmultiplemetrics.nf b/modules/nf-core/software/picard_collectmultiplemetrics.nf index aaaea4d63..37ab6a4f2 100644 --- a/modules/nf-core/software/picard_collectmultiplemetrics.nf +++ b/modules/nf-core/software/picard_collectmultiplemetrics.nf @@ -4,9 +4,9 @@ process PICARD_COLLECTMULTIPLEMETRICS { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" diff --git a/modules/nf-core/software/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf index 73ab8f0ac..793c37ba7 100644 --- a/modules/nf-core/software/picard_markduplicates.nf +++ b/modules/nf-core/software/picard_markduplicates.nf @@ -4,9 +4,9 @@ process PICARD_MARKDUPLICATES { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" diff --git a/modules/nf-core/software/picard_mergesamfiles.nf b/modules/nf-core/software/picard_mergesamfiles.nf index 19a7d8d6f..928f2dd60 100644 --- a/modules/nf-core/software/picard_mergesamfiles.nf +++ b/modules/nf-core/software/picard_mergesamfiles.nf @@ -4,9 +4,9 @@ process PICARD_MERGESAMFILES { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" diff --git a/modules/nf-core/software/preseq_lcextrap.nf b/modules/nf-core/software/preseq_lcextrap.nf index 6ba2a7a7e..34e156f51 100644 --- a/modules/nf-core/software/preseq_lcextrap.nf +++ b/modules/nf-core/software/preseq_lcextrap.nf @@ -5,9 +5,9 @@ process PRESEQ_LCEXTRAP { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/preseq:2.0.3--hf53bd2b_3" //container "https://depot.galaxyproject.org/singularity/preseq:2.0.3--hf53bd2b_3" diff --git a/modules/nf-core/software/samtools_flagstat.nf b/modules/nf-core/software/samtools_flagstat.nf index e641c5b0e..524dc6fda 100644 --- a/modules/nf-core/software/samtools_flagstat.nf +++ b/modules/nf-core/software/samtools_flagstat.nf @@ -3,9 +3,9 @@ process SAMTOOLS_FLAGSTAT { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_idxstats.nf b/modules/nf-core/software/samtools_idxstats.nf index cacd23baa..f4c2faf6f 100644 --- a/modules/nf-core/software/samtools_idxstats.nf +++ b/modules/nf-core/software/samtools_idxstats.nf @@ -3,9 +3,9 @@ process SAMTOOLS_IDXSTATS { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_index.nf b/modules/nf-core/software/samtools_index.nf index 1a99fcaca..c11c1bc60 100644 --- a/modules/nf-core/software/samtools_index.nf +++ b/modules/nf-core/software/samtools_index.nf @@ -3,9 +3,9 @@ process SAMTOOLS_INDEX { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_sort.nf b/modules/nf-core/software/samtools_sort.nf index a3532a5b7..05fa3207d 100644 --- a/modules/nf-core/software/samtools_sort.nf +++ b/modules/nf-core/software/samtools_sort.nf @@ -4,9 +4,9 @@ process SAMTOOLS_SORT { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_stats.nf b/modules/nf-core/software/samtools_stats.nf index 7a0d68c26..b3452d08c 100644 --- a/modules/nf-core/software/samtools_stats.nf +++ b/modules/nf-core/software/samtools_stats.nf @@ -3,9 +3,9 @@ process SAMTOOLS_STATS { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/trimgalore.nf b/modules/nf-core/software/trimgalore.nf index 1dcef6bd7..8c773426a 100644 --- a/modules/nf-core/software/trimgalore.nf +++ b/modules/nf-core/software/trimgalore.nf @@ -4,9 +4,9 @@ process TRIMGALORE { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/trim-galore:0.6.5--0" //container "https://depot.galaxyproject.org/singularity/trim-galore:0.6.5--0" diff --git a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf index 176b6b237..6b702e9dd 100644 --- a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf +++ b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf @@ -4,9 +4,9 @@ process UCSC_BEDRAPHTOBIGWIG { publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + if (opts.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } container "quay.io/biocontainers/ucsc-bedgraphtobigwig:377--h446ed27_1" //container "https://depot.galaxyproject.org/singularity/ucsc-bedgraphtobigwig:377--h446ed27_1" From 7cb42c2b81238e060cb28d5dd251e2acd7afda06 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Sat, 25 Jul 2020 14:30:45 +0100 Subject: [PATCH 064/538] Add in macs2 process --- conf/modules.config | 6 + main.nf | 165 +++++------------- modules/local/process/calc_frip.nf | 3 + .../nf-core/software/homer_annotatepeaks.nf | 11 +- modules/nf-core/software/macs2_callpeak.nf | 100 +++-------- 5 files changed, 83 insertions(+), 202 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 491aae56d..e4889221c 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -150,6 +150,12 @@ params { publish_dir = "bwa/mergedLibrary/deeptools" publish_results = "all" } + 'macs2_callpeak' { + args = "--keep-dup all" + suffix = "" + publish_dir = "bwa/mergedLibrary/macs2" + publish_results = "all" + } 'homer_annotatepeaks_macs2' { args = "-gid" suffix = ".mLb.clN" diff --git a/main.nf b/main.nf index 5e0950a7f..2c3ecd679 100755 --- a/main.nf +++ b/main.nf @@ -42,9 +42,6 @@ params.macs_gsize = params.genome ? params.genomes[ params.genome ].macs_gsize ? params.blacklist = params.genome ? params.genomes[ params.genome ].blacklist ?: false : false params.anno_readme = params.genome ? params.genomes[ params.genome ].readme ?: false : false -// Global variables -def PEAK_TYPE = params.narrow_peak ? 'narrowPeak' : 'broadPeak' - //////////////////////////////////////////////////// /* -- VALIDATE INPUTS -- */ //////////////////////////////////////////////////// @@ -162,8 +159,8 @@ include { DEEPTOOLS_PLOTPROFILE } from './modules/nf-core/software/deept include { DEEPTOOLS_PLOTHEATMAP } from './modules/nf-core/software/deeptools_plotheatmap' include { DEEPTOOLS_PLOTFINGERPRINT } from './modules/nf-core/software/deeptools_plotfingerprint' include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/software/phantompeakqualtools' -//include { MACSC2_CALLPEAK } from './modules/nf-core/software/macs2_callpeak' -//include { HOMER_ANNOTATEPEAKS } from './modules/nf-core/software/homer_annotatepeaks' +include { MACS2_CALLPEAK } from './modules/nf-core/software/macs2_callpeak' +include { HOMER_ANNOTATEPEAKS } from './modules/nf-core/software/homer_annotatepeaks' //include { SUBREAD_FEATURECOUNTS } from './modules/nf-core/software/subread_featurecounts' include { MULTIQC } from './modules/nf-core/software/multiqc' @@ -278,10 +275,10 @@ workflow { params.modules['picard_collectmultiplemetrics'] ) - PRESEQ_LCEXTRAP ( - CLEAN_BAM.out.bam, - params.modules['preseq_lcextrap'] - ) + // PRESEQ_LCEXTRAP ( + // CLEAN_BAM.out.bam, + // params.modules['preseq_lcextrap'] + // ) PHANTOMPEAKQUALTOOLS ( CLEAN_BAM.out.bam, @@ -328,6 +325,46 @@ workflow { params.modules['deeptools_plotfingerprint'] ) + /* + * Call peaks + */ + CLEAN_BAM + .out + .bam + .map { meta, bam -> meta.control ? null : [ meta.id, bam ] } + .set { ch_control_bam } + + // Create channel: [ val(meta), ip_bam, control_bam ] + CLEAN_BAM + .out + .bam + .map { meta, bam -> meta.control ? [ meta.control, meta, bam ] : null } + .combine(ch_control_bam, by: 0) + .map { it -> [ it[1] , it[2], it[3] ] } + .set { ch_control_bam } + + if (params.macs_gsize) { + peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' + broad = params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}" + pileup = params.save_macs_pileup ? '--bdg --SPMR' : '' + fdr = params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '' + pvalue = params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' + params.modules['macs2_callpeak'].publish_dir += "/$peakType" + params.modules['macs2_callpeak'].args += " $broad $pileup $fdr $pvalue" + MACS2_CALLPEAK ( + ch_control_bam, + params.macs_gsize, + params.modules['macs2_callpeak'] + ) + + HOMER_ANNOTATEPEAKS ( + MACS2_CALLPEAK.out.peak, + ch_fasta, + ch_gtf, + params.modules['homer_annotatepeaks_macs2'] + ) + } + /* * Pipeline reporting */ @@ -362,116 +399,6 @@ workflow.onComplete { /* -- THE END -- */ //////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// /* -- -- */ -// /* -- MERGE LIBRARY PEAK ANALYSIS -- */ -// /* -- -- */ -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// -// // Create channel linking IP bams with control bams -// ch_rm_orphan_bam_macs_1 -// .combine(ch_rm_orphan_bam_macs_2) -// .set { ch_rm_orphan_bam_macs_1 } -// -// ch_design_controls_csv -// .combine(ch_rm_orphan_bam_macs_1) -// .filter { it[0] == it[5] && it[1] == it[7] } -// .join(ch_rm_orphan_flagstat_macs) -// .map { it -> it[2..-1] } -// .into { ch_group_bam_macs; -// ch_group_bam_plotfingerprint; -// ch_group_bam_counts } -// -// /* -// * STEP 6.2: Call peaks with MACS2 and calculate FRiP score -// */ -// process MACS2 { -// tag "${ip} vs ${control}" -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (filename.endsWith('.tsv')) "qc/$filename" -// else if (filename.endsWith('.igv.txt')) null -// else filename -// } -// -// when: -// params.macs_gsize -// -// input: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), path(ipbam), val(control), path(controlbam), path(ipflagstat) from ch_group_bam_macs -// path peak_count_header from ch_peak_count_header -// path frip_score_header from ch_frip_score_header -// -// output: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), val(control), path("*.$PEAK_TYPE") into ch_macs_homer, -// ch_macs_qc, -// ch_macs_consensus -// path '*igv.txt' into ch_macs_igv -// path '*_mqc.tsv' into ch_macs_mqc -// path '*.{bed,xls,gappedPeak,bdg}' -// -// script: -// broad = params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}" -// format = params.single_end ? 'BAM' : 'BAMPE' -// pileup = params.save_macs_pileup ? '-B --SPMR' : '' -// fdr = params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '' -// pvalue = params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' -// """ -// macs2 callpeak \\ -// -t ${ipbam[0]} \\ -// -c ${controlbam[0]} \\ -// $broad \\ -// -f $format \\ -// -g $params.macs_gsize \\ -// -n $ip \\ -// $pileup \\ -// $fdr \\ -// $pvalue \\ -// --keep-dup all -// -// cat ${ip}_peaks.${PEAK_TYPE} | wc -l | awk -v OFS='\t' '{ print "${ip}", \$1 }' | cat $peak_count_header - > ${ip}_peaks.count_mqc.tsv -// -// READS_IN_PEAKS=\$(intersectBed -a ${ipbam[0]} -b ${ip}_peaks.${PEAK_TYPE} -bed -c -f 0.20 | awk -F '\t' '{sum += \$NF} END {print sum}') -// grep 'mapped (' $ipflagstat | awk -v a="\$READS_IN_PEAKS" -v OFS='\t' '{print "${ip}", a/\$1}' | cat $frip_score_header - > ${ip}_peaks.FRiP_mqc.tsv -// -// find * -type f -name "*.${PEAK_TYPE}" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/"{}"\\t0,0,178" \\; > ${ip}_peaks.igv.txt -// """ -// } -// -// /* -// * STEP 6.3: Annotate peaks with HOMER -// */ -// process MACS2_ANNOTATE { -// tag "${ip} vs ${control}" -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}", mode: params.publish_dir_mode -// -// when: -// params.macs_gsize && !params.skip_peak_annotation -// -// input: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), val(control), path(peak) from ch_macs_homer -// path fasta from ch_fasta -// path gtf from ch_gtf -// -// output: -// path '*.txt' into ch_macs_annotate -// -// script: -// """ -// annotatePeaks.pl \\ -// $peak \\ -// $fasta \\ -// -gid \\ -// -gtf $gtf \\ -// -cpu $task.cpus \\ -// > ${ip}_peaks.annotatePeaks.txt -// """ -// } -// // /* // * STEP 6.4: Aggregated QC plots for peaks, FRiP and peak-to-gene annotation // */ diff --git a/modules/local/process/calc_frip.nf b/modules/local/process/calc_frip.nf index a90c447d1..3ccc18853 100644 --- a/modules/local/process/calc_frip.nf +++ b/modules/local/process/calc_frip.nf @@ -1 +1,4 @@ conda (params.conda ? "${baseDir}/environment.yml" : null) + +READS_IN_PEAKS=\$(intersectBed -a ${ipbam[0]} -b ${ip}_peaks.${PEAK_TYPE} -bed -c -f 0.20 | awk -F '\t' '{sum += \$NF} END {print sum}') +grep 'mapped (' $ipflagstat | awk -v a="\$READS_IN_PEAKS" -v OFS='\t' '{print "${ip}", a/\$1}' | cat $frip_score_header - > ${ip}_peaks.FRiP_mqc.tsv diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf index c45b7383f..33fba69cd 100644 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ b/modules/nf-core/software/homer_annotatepeaks.nf @@ -1,3 +1,5 @@ +def VERSION = 4.11 + process HOMER_ANNOTATEPEAKS { tag "$meta.id" label 'process_medium' @@ -14,7 +16,7 @@ process HOMER_ANNOTATEPEAKS { conda (params.conda ? "bioconda::homer=4.11" : null) input: - tuple val(meta), path(bed) + tuple val(meta), path(peak) path fasta path gtf val opts @@ -25,16 +27,15 @@ process HOMER_ANNOTATEPEAKS { script: prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" - """ annotatePeaks.pl \\ - $opts.args \\ - $bed \\ + $peak \\ $fasta \\ + $opts.args \\ -gtf $gtf \\ -cpu $task.cpus \\ > ${prefix}.annotatePeaks.txt - touch homer.version.txt + echo $VERSION > homer.version.txt """ } diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf index 67b4e84ad..2cf8c3ae0 100644 --- a/modules/nf-core/software/macs2_callpeak.nf +++ b/modules/nf-core/software/macs2_callpeak.nf @@ -1,8 +1,3 @@ -container "quay.io/biocontainers/macs2:2.2.7.1--py37h516909a_0" -//container "https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py37h516909a_0" -//echo \$(macs2 --version 2>&1) > macs2.version.txt -conda (params.conda ? "bioconda::macs2=2.2.7.1" : null) - process MACS2_CALLPEAK { tag "$meta.id" label 'process_medium' @@ -13,92 +8,41 @@ process MACS2_CALLPEAK { else if (filename.endsWith('.version.txt')) null else filename } - container "quay.io/biocontainers/homer:4.11--pl526h9a982cc_2" - //container "https://depot.galaxyproject.org/singularity/homer:4.11--pl526h9a982cc_2" + container "quay.io/biocontainers/macs2:2.2.7.1--py37h516909a_0" + //container "https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py37h516909a_0" - conda (params.conda ? "bioconda::homer=4.11" : null) + conda (params.conda ? "bioconda::macs2=2.2.7.1" : null) input: - tuple val(meta), path(bed) - path fasta - path gtf + tuple val(meta), path(ipbam), path(controlbam) + val macs2_gsize val opts output: - tuple val(meta), path("*.txt"), emit: txt + tuple val(meta), path("*.{narrowPeak,broadPeak}"), emit: peak + path '*.xls', emit: xls + path '*.gappedPeak', emit: gapped optional true + path '*.bed', emit: bed optional true + path '*.bdg', emit: bdg optional true path "*.version.txt", emit: version script: prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" - + format = meta.single_end ? 'BAM' : 'BAMPE' + control = controlbam ? "--control $controlbam" : '' """ - annotatePeaks.pl \\ + macs2 \\ + callpeak \\ $opts.args \\ - $bed \\ - $fasta \\ - -gtf $gtf \\ - -cpu $task.cpus \\ - > ${prefix}.annotatePeaks.txt + --gsize $macs2_gsize \\ + --format $format \\ + --name $prefix \\ + --treatment $ipbam \\ + $control - touch homer.version.txt + echo \$(macs2 --version 2>&1) > macs2.version.txt """ } - - - -// /* -// * STEP 6.2: Call peaks with MACS2 and calculate FRiP score -// */ -// process MACS2 { -// tag "${ip} vs ${control}" -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (filename.endsWith('.tsv')) "qc/$filename" -// else if (filename.endsWith('.igv.txt')) null -// else filename -// } -// -// when: -// params.macs_gsize -// -// input: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), path(ipbam), val(control), path(controlbam), path(ipflagstat) from ch_group_bam_macs -// path peak_count_header from ch_peak_count_header -// path frip_score_header from ch_frip_score_header -// -// output: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), val(ip), val(control), path("*.$PEAK_TYPE") into ch_macs_homer, -// ch_macs_qc, -// ch_macs_consensus -// path '*igv.txt' into ch_macs_igv -// path '*_mqc.tsv' into ch_macs_mqc -// path '*.{bed,xls,gappedPeak,bdg}' -// -// script: -// broad = params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}" -// format = params.single_end ? 'BAM' : 'BAMPE' -// pileup = params.save_macs_pileup ? '-B --SPMR' : '' -// fdr = params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '' -// pvalue = params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' -// """ -// macs2 callpeak \\ -// -t ${ipbam[0]} \\ -// -c ${controlbam[0]} \\ -// $broad \\ -// -f $format \\ -// -g $params.macs_gsize \\ -// -n $ip \\ -// $pileup \\ -// $fdr \\ -// $pvalue \\ -// --keep-dup all -// -// cat ${ip}_peaks.${PEAK_TYPE} | wc -l | awk -v OFS='\t' '{ print "${ip}", \$1 }' | cat $peak_count_header - > ${ip}_peaks.count_mqc.tsv -// -// READS_IN_PEAKS=\$(intersectBed -a ${ipbam[0]} -b ${ip}_peaks.${PEAK_TYPE} -bed -c -f 0.20 | awk -F '\t' '{sum += \$NF} END {print sum}') -// grep 'mapped (' $ipflagstat | awk -v a="\$READS_IN_PEAKS" -v OFS='\t' '{print "${ip}", a/\$1}' | cat $frip_score_header - > ${ip}_peaks.FRiP_mqc.tsv +// cat ${ip}_peaks.${PEAK_TYPE} | wc -l | awk -v OFS='\t' '{ print "${ip}", \$1 }' | cat $peak_count_header - > ${ip}_peaks.count_mqc.tsv // -// find * -type f -name "*.${PEAK_TYPE}" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/"{}"\\t0,0,178" \\; > ${ip}_peaks.igv.txt -// """ -// } +// find * -type f -name "*.${PEAK_TYPE}" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/"{}"\\t0,0,178" \\; > ${ip}_peaks.igv.txt From 4c38f5d9c2071839098fa0ca60e2f8e0013b1f63 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Sat, 25 Jul 2020 14:42:07 +0100 Subject: [PATCH 065/538] Use biocontainers where possible in local modules --- conf/modules.config | 2 +- main.nf | 3 ++- modules/local/process/bedtools_genomecov.nf | 5 ++++- modules/local/process/get_chrom_sizes.nf | 7 +++++-- modules/local/process/gtf2bed.nf | 5 ++++- modules/local/process/make_genome_filter.nf | 5 ++++- 6 files changed, 20 insertions(+), 7 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index e4889221c..b84f21dfb 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -159,7 +159,7 @@ params { 'homer_annotatepeaks_macs2' { args = "-gid" suffix = ".mLb.clN" - publish_dir = "bwa/mergedLibrary/homer" + publish_dir = "bwa/mergedLibrary/macs2" publish_results = "all" } 'get_software_versions' { diff --git a/main.nf b/main.nf index 2c3ecd679..96bb22320 100755 --- a/main.nf +++ b/main.nf @@ -357,12 +357,13 @@ workflow { params.modules['macs2_callpeak'] ) + params.modules['homer_annotatepeaks_macs2'].publish_dir += "/$peakType" HOMER_ANNOTATEPEAKS ( MACS2_CALLPEAK.out.peak, ch_fasta, ch_gtf, params.modules['homer_annotatepeaks_macs2'] - ) + ) } /* diff --git a/modules/local/process/bedtools_genomecov.nf b/modules/local/process/bedtools_genomecov.nf index 7b0860ba1..e72aebb58 100644 --- a/modules/local/process/bedtools_genomecov.nf +++ b/modules/local/process/bedtools_genomecov.nf @@ -8,7 +8,10 @@ process BEDTOOLS_GENOMECOV { else if (filename.endsWith('.version.txt')) null else filename } - conda (params.conda ? "${baseDir}/environment.yml" : null) + container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" + //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" + + conda (params.conda ? "bioconda::bedtools=2.29.2" : null) input: tuple val(meta), path(bam), path(flagstat) diff --git a/modules/local/process/get_chrom_sizes.nf b/modules/local/process/get_chrom_sizes.nf index 6051b4dfd..811bdfa66 100644 --- a/modules/local/process/get_chrom_sizes.nf +++ b/modules/local/process/get_chrom_sizes.nf @@ -9,8 +9,11 @@ process GET_CHROM_SIZES { if (opts.publish_results == "none") null else filename } - conda (params.conda ? "${baseDir}/environment.yml" : null) - + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "bioconda::samtools=1.10" : null) + input: path fasta val opts diff --git a/modules/local/process/gtf2bed.nf b/modules/local/process/gtf2bed.nf index bcc2848e2..9abce96e6 100644 --- a/modules/local/process/gtf2bed.nf +++ b/modules/local/process/gtf2bed.nf @@ -10,7 +10,10 @@ process GTF2BED { if (opts.publish_results == "none") null else filename } - conda (params.conda ? "${baseDir}/environment.yml" : null) + container "quay.io/biocontainers/perl:5.26.2" + //container "https://depot.galaxyproject.org/singularity/perl:5.26.2" + + conda (params.conda ? "conda-forge::perl=5.26.2" : null) input: path gtf diff --git a/modules/local/process/make_genome_filter.nf b/modules/local/process/make_genome_filter.nf index 542d566c5..bfc5a2506 100644 --- a/modules/local/process/make_genome_filter.nf +++ b/modules/local/process/make_genome_filter.nf @@ -9,7 +9,10 @@ process MAKE_GENOME_FILTER { if (opts.publish_results == "none") null else filename } - conda (params.conda ? "${baseDir}/environment.yml" : null) + container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" + //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" + + conda (params.conda ? "bioconda::bedtools=2.29.2" : null) input: path sizes From c6a02fa531aafec234b5f01ba859f7f2fd202bdd Mon Sep 17 00:00:00 2001 From: drpatelh Date: Sat, 25 Jul 2020 16:02:31 +0100 Subject: [PATCH 066/538] Add commands to get software version --- main.nf | 2 +- modules/local/process/bedtools_genomecov.nf | 4 +++- modules/local/process/get_chrom_sizes.nf | 4 ++++ modules/local/process/make_genome_filter.nf | 7 ++++++- modules/nf-core/software/bwa_index.nf | 4 +++- modules/nf-core/software/bwa_mem.nf | 5 ++++- modules/nf-core/software/deeptools_computematrix.nf | 4 +++- modules/nf-core/software/deeptools_plotfingerprint.nf | 6 ++++-- modules/nf-core/software/deeptools_plotheatmap.nf | 6 ++++-- modules/nf-core/software/deeptools_plotprofile.nf | 6 ++++-- modules/nf-core/software/fastqc.nf | 6 ++++-- modules/nf-core/software/homer_annotatepeaks.nf | 5 +++-- modules/nf-core/software/macs2_callpeak.nf | 4 +++- modules/nf-core/software/multiqc.nf | 9 ++++----- modules/nf-core/software/phantompeakqualtools.nf | 5 ++++- .../nf-core/software/picard_collectmultiplemetrics.nf | 5 ++++- modules/nf-core/software/picard_markduplicates.nf | 7 +++++-- modules/nf-core/software/picard_mergesamfiles.nf | 8 +++++--- modules/nf-core/software/preseq_lcextrap.nf | 5 ++++- modules/nf-core/software/samtools_flagstat.nf | 4 +++- modules/nf-core/software/samtools_idxstats.nf | 6 ++++-- modules/nf-core/software/samtools_index.nf | 6 ++++-- modules/nf-core/software/samtools_sort.nf | 4 +++- modules/nf-core/software/samtools_stats.nf | 6 ++++-- modules/nf-core/software/subread_featurecounts.nf | 2 ++ modules/nf-core/software/trimgalore.nf | 6 ++++-- modules/nf-core/software/ucsc_bedgraphtobigwig.nf | 4 ++++ 27 files changed, 100 insertions(+), 40 deletions(-) diff --git a/main.nf b/main.nf index 96bb22320..e4763c3f3 100755 --- a/main.nf +++ b/main.nf @@ -259,7 +259,7 @@ workflow { // Fix getting name sorted BAM here for PE/SE CLEAN_BAM ( MARK_DUPLICATES.out.bam.join(MARK_DUPLICATES.out.bai, by: [0]), - MAKE_GENOME_FILTER.out.collect(), + MAKE_GENOME_FILTER.out.bed.collect(), ch_bamtools_filter_config, params.modules['filter_bam'], params.modules['remove_bam_orphans'], diff --git a/modules/local/process/bedtools_genomecov.nf b/modules/local/process/bedtools_genomecov.nf index e72aebb58..b167d11fc 100644 --- a/modules/local/process/bedtools_genomecov.nf +++ b/modules/local/process/bedtools_genomecov.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'bedtools' + process BEDTOOLS_GENOMECOV { tag "$meta.id" label 'process_medium' @@ -39,6 +41,6 @@ process BEDTOOLS_GENOMECOV { $extend \\ | sort -T '.' -k1,1 -k2,2n > ${prefix}.bedGraph - bedtools --version > bedtools.version.txt + bedtools --version | sed -e "s/bedtools v//g" > ${SOFTWARE}.version.txt """ } diff --git a/modules/local/process/get_chrom_sizes.nf b/modules/local/process/get_chrom_sizes.nf index 811bdfa66..b90e23ab1 100644 --- a/modules/local/process/get_chrom_sizes.nf +++ b/modules/local/process/get_chrom_sizes.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'samtools' + /* * Get chromosome sizes from a fasta file */ @@ -21,10 +23,12 @@ process GET_CHROM_SIZES { output: path '*.sizes', emit: sizes path '*.fai', emit: fai + path "*.version.txt", emit: version script: """ samtools faidx $fasta cut -f 1,2 ${fasta}.fai > ${fasta}.sizes + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/local/process/make_genome_filter.nf b/modules/local/process/make_genome_filter.nf index bfc5a2506..59addb3e4 100644 --- a/modules/local/process/make_genome_filter.nf +++ b/modules/local/process/make_genome_filter.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'bedtools' + /* * Prepare genome intervals for filtering by removing regions in blacklist file */ @@ -20,17 +22,20 @@ process MAKE_GENOME_FILTER { val opts output: - path '*.bed' + path '*.bed', emit: bed + path "*.version.txt", emit: version script: file_out = "${sizes.simpleName}.include_regions.bed" if (params.blacklist) { """ sortBed -i $blacklist -g $sizes | complementBed -i stdin -g $sizes > $file_out + bedtools --version | sed -e "s/bedtools v//g" > ${SOFTWARE}.version.txt """ } else { """ awk '{print \$1, '0' , \$2}' OFS='\t' $sizes > $file_out + bedtools --version | sed -e "s/bedtools v//g" > ${SOFTWARE}.version.txt """ } } diff --git a/modules/nf-core/software/bwa_index.nf b/modules/nf-core/software/bwa_index.nf index 775e0254b..cbe788bd7 100644 --- a/modules/nf-core/software/bwa_index.nf +++ b/modules/nf-core/software/bwa_index.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'bwa' + process BWA_INDEX { tag "$fasta" label 'process_high' @@ -24,6 +26,6 @@ process BWA_INDEX { script: """ bwa index $opts.args $fasta - echo \$(bwa 2>&1) | sed -n "s/.*\\(v.*\$\\)/\\1/p" > bwa.version.txt + echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/bwa_mem.nf b/modules/nf-core/software/bwa_mem.nf index ff8657c88..73012e770 100644 --- a/modules/nf-core/software/bwa_mem.nf +++ b/modules/nf-core/software/bwa_mem.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'bwa' + process BWA_MEM { tag "$meta.id" label 'process_high' @@ -34,6 +36,7 @@ process BWA_MEM { $fasta \\ $reads \\ | samtools view $opts.args2 -@ $task.cpus -bS -o ${prefix}.bam - - echo \$(bwa 2>&1) | sed -n "s/.*\\(v.*\$\\)/\\1/p" > bwa.version.txt + + echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/deeptools_computematrix.nf b/modules/nf-core/software/deeptools_computematrix.nf index 7d597f69b..f1d303a56 100644 --- a/modules/nf-core/software/deeptools_computematrix.nf +++ b/modules/nf-core/software/deeptools_computematrix.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'deeptools' + process DEEPTOOLS_COMPUTEMATRIX { tag "$meta.id" label 'process_high' @@ -34,6 +36,6 @@ process DEEPTOOLS_COMPUTEMATRIX { --outFileNameMatrix ${prefix}.computeMatrix.vals.mat.tab \\ --numberOfProcessors $task.cpus - echo \$(computeMatrix --version 2>&1) > deeptools.version.txt || true + computeMatrix --version | sed -e "s/computeMatrix //g" > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/deeptools_plotfingerprint.nf b/modules/nf-core/software/deeptools_plotfingerprint.nf index dec02162d..35f706535 100644 --- a/modules/nf-core/software/deeptools_plotfingerprint.nf +++ b/modules/nf-core/software/deeptools_plotfingerprint.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'deeptools' + process DEEPTOOLS_PLOTFINGERPRINT { tag "$meta.id" label 'process_high' @@ -12,7 +14,7 @@ process DEEPTOOLS_PLOTFINGERPRINT { //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" conda (params.conda ? "bioconda::deeptools=3.4.3" : null) - + input: tuple val(meta), path(bams), path(bais) val opts @@ -36,6 +38,6 @@ process DEEPTOOLS_PLOTFINGERPRINT { --outQualityMetrics ${prefix}.plotFingerprint.qcmetrics.txt \\ --numberOfProcessors $task.cpus - echo \$(plotFingerprint --version 2>&1) > deeptools.version.txt || true + plotFingerprint --version | sed -e "s/plotFingerprint //g" > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/deeptools_plotheatmap.nf b/modules/nf-core/software/deeptools_plotheatmap.nf index 501fa106a..fa9787136 100644 --- a/modules/nf-core/software/deeptools_plotheatmap.nf +++ b/modules/nf-core/software/deeptools_plotheatmap.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'deeptools' + process DEEPTOOLS_PLOTHEATMAP { tag "$meta.id" label 'process_low' @@ -12,7 +14,7 @@ process DEEPTOOLS_PLOTHEATMAP { //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" conda (params.conda ? "bioconda::deeptools=3.4.3" : null) - + input: tuple val(meta), path(matrix) val opts @@ -31,6 +33,6 @@ process DEEPTOOLS_PLOTHEATMAP { --outFileName ${prefix}.plotHeatmap.pdf \\ --outFileNameMatrix ${prefix}.plotHeatmap.mat.tab - echo \$(plotHeatmap --version 2>&1) > deeptools.version.txt || true + plotHeatmap --version | sed -e "s/plotHeatmap //g" > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/deeptools_plotprofile.nf b/modules/nf-core/software/deeptools_plotprofile.nf index 35ee9b2ec..b90c171a9 100644 --- a/modules/nf-core/software/deeptools_plotprofile.nf +++ b/modules/nf-core/software/deeptools_plotprofile.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'deeptools' + process DEEPTOOLS_PLOTPROFILE { tag "$meta.id" label 'process_low' @@ -12,7 +14,7 @@ process DEEPTOOLS_PLOTPROFILE { //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" conda (params.conda ? "bioconda::deeptools=3.4.3" : null) - + input: tuple val(meta), path(matrix) val opts @@ -31,6 +33,6 @@ process DEEPTOOLS_PLOTPROFILE { --outFileName ${prefix}.plotProfile.pdf \\ --outFileNameData ${prefix}.plotProfile.tab - echo \$(plotProfile --version 2>&1) > deeptools.version.txt || true + plotProfile --version | sed -e "s/plotProfile //g" > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/fastqc.nf b/modules/nf-core/software/fastqc.nf index c6adb0693..4a69d8218 100755 --- a/modules/nf-core/software/fastqc.nf +++ b/modules/nf-core/software/fastqc.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'fastqc' + process FASTQC { tag "$meta.id" label 'process_medium' @@ -29,14 +31,14 @@ process FASTQC { """ [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz fastqc $opts.args --threads $task.cpus ${prefix}.fastq.gz - fastqc --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > fastqc.version.txt + fastqc --version | sed -e "s/FastQC v//g" > ${SOFTWARE}.version.txt """ } else { """ [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz fastqc $opts.args --threads $task.cpus ${prefix}_1.fastq.gz ${prefix}_2.fastq.gz - fastqc --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > fastqc.version.txt + fastqc --version | sed -e "s/FastQC v//g" > ${SOFTWARE}.version.txt """ } } diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf index 33fba69cd..1e0a2f362 100644 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ b/modules/nf-core/software/homer_annotatepeaks.nf @@ -1,4 +1,5 @@ -def VERSION = 4.11 +def SOFTWARE = 'homer' +def VERSION = '4.11' process HOMER_ANNOTATEPEAKS { tag "$meta.id" @@ -36,6 +37,6 @@ process HOMER_ANNOTATEPEAKS { -cpu $task.cpus \\ > ${prefix}.annotatePeaks.txt - echo $VERSION > homer.version.txt + echo $VERSION > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf index 2cf8c3ae0..f28d6908f 100644 --- a/modules/nf-core/software/macs2_callpeak.nf +++ b/modules/nf-core/software/macs2_callpeak.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'macs2' + process MACS2_CALLPEAK { tag "$meta.id" label 'process_medium' @@ -40,7 +42,7 @@ process MACS2_CALLPEAK { --treatment $ipbam \\ $control - echo \$(macs2 --version 2>&1) > macs2.version.txt + macs2 --version | sed -e "s/macs2 //g" > ${SOFTWARE}.version.txt """ } // cat ${ip}_peaks.${PEAK_TYPE} | wc -l | awk -v OFS='\t' '{ print "${ip}", \$1 }' | cat $peak_count_header - > ${ip}_peaks.count_mqc.tsv diff --git a/modules/nf-core/software/multiqc.nf b/modules/nf-core/software/multiqc.nf index 8ec114575..8280307da 100755 --- a/modules/nf-core/software/multiqc.nf +++ b/modules/nf-core/software/multiqc.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'multiqc' + // Has the run name been specified by the user? // this has the bonus effect of catching both -name and --name custom_runName = params.name @@ -21,9 +23,6 @@ if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { // """.stripIndent() } // .set { ch_workflow_summary } -/* - * MultiQC - */ process MULTIQC { publishDir "${params.outdir}/multiqc", mode: params.publish_dir_mode @@ -31,7 +30,7 @@ process MULTIQC { //container "https://depot.galaxyproject.org/singularity/multiqc:1.9--pyh9f0ad1d_0" conda (params.conda ? "bioconda::multiqc=1.9" : null) - + input: path (multiqc_config) from ch_multiqc_config path (mqc_custom_config) from ch_multiqc_custom_config.collect().ifEmpty([]) @@ -52,6 +51,6 @@ process MULTIQC { // TODO nf-core: Specify which MultiQC modules to use with -m for a faster run time """ multiqc -f $rtitle $rfilename $custom_config_file . - multiqc --version > multiqc.version.txt + multiqc --version | sed -e "s/multiqc, version //g" > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf index 44db1529c..22b2d9e74 100644 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ b/modules/nf-core/software/phantompeakqualtools.nf @@ -1,3 +1,6 @@ +def SOFTWARE = 'phantompeakqualtools' +def VERSION = '1.2.2' + process PHANTOMPEAKQUALTOOLS { tag "$meta.id" label 'process_medium' @@ -29,6 +32,6 @@ process PHANTOMPEAKQUALTOOLS { Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus Rscript -e "load('${prefix}.spp.Rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}_spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" - touch phantompeakqualtools.version.txt + echo $VERSION > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/picard_collectmultiplemetrics.nf b/modules/nf-core/software/picard_collectmultiplemetrics.nf index 37ab6a4f2..8b3371c9a 100644 --- a/modules/nf-core/software/picard_collectmultiplemetrics.nf +++ b/modules/nf-core/software/picard_collectmultiplemetrics.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'picard' + process PICARD_COLLECTMULTIPLEMETRICS { tag "$meta.id" label 'process_medium' @@ -39,6 +41,7 @@ process PICARD_COLLECTMULTIPLEMETRICS { INPUT=$bam \\ OUTPUT=${prefix}.CollectMultipleMetrics \\ REFERENCE_SEQUENCE=$fasta - picard CollectMultipleMetrics --version &> picard.version.txt || true + + echo \$(picard CollectMultipleMetrics --version 2>&1) | awk -F' ' '{print \$NF}' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf index 793c37ba7..9636e0506 100644 --- a/modules/nf-core/software/picard_markduplicates.nf +++ b/modules/nf-core/software/picard_markduplicates.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'picard' + process PICARD_MARKDUPLICATES { tag "$meta.id" label 'process_medium' @@ -12,7 +14,7 @@ process PICARD_MARKDUPLICATES { //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" conda (params.conda ? "bioconda::picard=2.23.2" : null) - + input: tuple val(meta), path(bam) val opts @@ -38,6 +40,7 @@ process PICARD_MARKDUPLICATES { INPUT=$bam \\ OUTPUT=${prefix}.bam \\ METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt - picard MarkDuplicates --version &> picard.version.txt || true + + echo \$(picard MarkDuplicates --version 2>&1) | awk -F' ' '{print \$NF}' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/picard_mergesamfiles.nf b/modules/nf-core/software/picard_mergesamfiles.nf index 928f2dd60..466d767ca 100644 --- a/modules/nf-core/software/picard_mergesamfiles.nf +++ b/modules/nf-core/software/picard_mergesamfiles.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'picard' + process PICARD_MERGESAMFILES { tag "$meta.id" label 'process_medium' @@ -12,7 +14,7 @@ process PICARD_MERGESAMFILES { //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" conda (params.conda ? "bioconda::picard=2.23.2" : null) - + input: tuple val(meta), path(bams) val opts @@ -38,12 +40,12 @@ process PICARD_MERGESAMFILES { $opts.args \\ ${'INPUT='+bam_files.join(' INPUT=')} \\ OUTPUT=${prefix}.bam - picard MergeSamFiles --version &> picard.version.txt || true + echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${SOFTWARE}.version.txt """ } else { """ ln -s ${bam_files[0]} ${prefix}.bam - picard MergeSamFiles --version &> picard.version.txt || true + echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${SOFTWARE}.version.txt """ } } diff --git a/modules/nf-core/software/preseq_lcextrap.nf b/modules/nf-core/software/preseq_lcextrap.nf index 34e156f51..b537077e9 100644 --- a/modules/nf-core/software/preseq_lcextrap.nf +++ b/modules/nf-core/software/preseq_lcextrap.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'preseq' + process PRESEQ_LCEXTRAP { tag "$meta.id" label 'process_medium' @@ -34,6 +36,7 @@ process PRESEQ_LCEXTRAP { -output ${prefix}.ccurve.txt \\ $bam cp .command.err ${prefix}.command.log - preseq &> preseq.version.txt + + echo \$(preseq 2>&1) | sed 's/^.*Version: //; s/Usage:.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/samtools_flagstat.nf b/modules/nf-core/software/samtools_flagstat.nf index 524dc6fda..537ab8cf6 100644 --- a/modules/nf-core/software/samtools_flagstat.nf +++ b/modules/nf-core/software/samtools_flagstat.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'samtools' + process SAMTOOLS_FLAGSTAT { tag "$meta.id" publishDir "${params.outdir}/${opts.publish_dir}", @@ -23,6 +25,6 @@ process SAMTOOLS_FLAGSTAT { script: """ samtools flagstat $bam > ${bam}.flagstat - samtools --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > samtools.version.txt + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/samtools_idxstats.nf b/modules/nf-core/software/samtools_idxstats.nf index f4c2faf6f..cdedf6bdf 100644 --- a/modules/nf-core/software/samtools_idxstats.nf +++ b/modules/nf-core/software/samtools_idxstats.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'samtools' + process SAMTOOLS_IDXSTATS { tag "$meta.id" publishDir "${params.outdir}/${opts.publish_dir}", @@ -11,7 +13,7 @@ process SAMTOOLS_IDXSTATS { //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" conda (params.conda ? "bioconda::samtools=1.10" : null) - + input: tuple val(meta), path(bam), path(bai) val opts @@ -23,6 +25,6 @@ process SAMTOOLS_IDXSTATS { script: """ samtools idxstats $bam > ${bam}.idxstats - samtools --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > samtools.version.txt + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/samtools_index.nf b/modules/nf-core/software/samtools_index.nf index c11c1bc60..7c17e1fe0 100644 --- a/modules/nf-core/software/samtools_index.nf +++ b/modules/nf-core/software/samtools_index.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'samtools' + process SAMTOOLS_INDEX { tag "$meta.id" publishDir "${params.outdir}/${opts.publish_dir}", @@ -11,7 +13,7 @@ process SAMTOOLS_INDEX { //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" conda (params.conda ? "bioconda::samtools=1.10" : null) - + input: tuple val(meta), path(bam) val opts @@ -23,6 +25,6 @@ process SAMTOOLS_INDEX { script: """ samtools index $bam - samtools --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > samtools.version.txt + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/samtools_sort.nf b/modules/nf-core/software/samtools_sort.nf index 05fa3207d..61289303d 100644 --- a/modules/nf-core/software/samtools_sort.nf +++ b/modules/nf-core/software/samtools_sort.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'samtools' + process SAMTOOLS_SORT { tag "$meta.id" label 'process_medium' @@ -25,6 +27,6 @@ process SAMTOOLS_SORT { prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" """ samtools sort $opts.args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam - samtools --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > samtools.version.txt + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/samtools_stats.nf b/modules/nf-core/software/samtools_stats.nf index b3452d08c..55f125797 100644 --- a/modules/nf-core/software/samtools_stats.nf +++ b/modules/nf-core/software/samtools_stats.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'samtools' + process SAMTOOLS_STATS { tag "$meta.id" publishDir "${params.outdir}/${opts.publish_dir}", @@ -11,7 +13,7 @@ process SAMTOOLS_STATS { //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" conda (params.conda ? "bioconda::samtools=1.10" : null) - + input: tuple val(meta), path(bam), path(bai) val opts @@ -23,6 +25,6 @@ process SAMTOOLS_STATS { script: """ samtools stats $bam > ${bam}.stats - samtools --version | sed -n "s/.*\\(v.*\$\\)/\\1/p" > samtools.version.txt + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/subread_featurecounts.nf b/modules/nf-core/software/subread_featurecounts.nf index c50b2bc79..536aa7e8b 100644 --- a/modules/nf-core/software/subread_featurecounts.nf +++ b/modules/nf-core/software/subread_featurecounts.nf @@ -1,7 +1,9 @@ +def SOFTWARE = 'subread' container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" //container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" //echo \$(featureCounts -v 2>&1) > featurecounts.version.txt conda (params.conda ? "bioconda::subread=2.0.1" : null) +//echo \$(featureCounts -v 2>&1) | sed -e "s/featureCounts v//g" > ${SOFTWARE}.version.txt // /* // * STEP 7.3: Count reads in consensus peaks with featureCounts diff --git a/modules/nf-core/software/trimgalore.nf b/modules/nf-core/software/trimgalore.nf index 8c773426a..ab1bd37a5 100644 --- a/modules/nf-core/software/trimgalore.nf +++ b/modules/nf-core/software/trimgalore.nf @@ -1,3 +1,5 @@ +def SOFTWARE = 'trimgalore' + process TRIMGALORE { tag "$meta.id" label 'process_high' @@ -54,7 +56,7 @@ process TRIMGALORE { $c_r1 \\ $tpc_r1 \\ ${prefix}.fastq.gz - trim_galore --version > trim_galore.version.txt + echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//' > ${SOFTWARE}.version.txt """ } else { """ @@ -71,7 +73,7 @@ process TRIMGALORE { $tpc_r2 \\ ${prefix}_1.fastq.gz \\ ${prefix}_2.fastq.gz - trim_galore --version > trim_galore.version.txt + echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//' > ${SOFTWARE}.version.txt """ } } diff --git a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf index 6b702e9dd..828dd647f 100644 --- a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf +++ b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf @@ -1,3 +1,6 @@ +def SOFTWARE = 'ucsc' +def VERSION = '377' + process UCSC_BEDRAPHTOBIGWIG { tag "$meta.id" label 'process_medium' @@ -25,5 +28,6 @@ process UCSC_BEDRAPHTOBIGWIG { prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" """ bedGraphToBigWig $bedgraph $sizes ${prefix}.bigWig + echo $VERSION > ${SOFTWARE}.version.txt """ } From 7ee543803fe60fed37237d36711c44a1b00edce3 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Sat, 25 Jul 2020 16:21:13 +0100 Subject: [PATCH 067/538] Add Groovy workflow_summary --- lib/Schema.groovy | 16 ++++++++++++++++ main.nf | 15 +++++++++++---- modules/nf-core/software/multiqc.nf | 16 ---------------- 3 files changed, 27 insertions(+), 20 deletions(-) diff --git a/lib/Schema.groovy b/lib/Schema.groovy index e07e454c3..3f25c88f0 100755 --- a/lib/Schema.groovy +++ b/lib/Schema.groovy @@ -166,4 +166,20 @@ class Schema { } return summary } + + static String params_mqc_summary(summary) { + String yaml_file_text = """ + id: 'nf-core-chipseq-summary' + description: " - this information is collected when the pipeline is started." + section_name: 'nf-core/chipseq Workflow Summary' + section_href: 'https://github.com/nf-core/chipseq' + plot_type: 'html' + data: | +
+ ${summary.collect { k,v -> "
$k
${v ?: 'N/A'}
" }.join("\n")} +
+ """.stripIndent() + + return yaml_file_text + } } diff --git a/main.nf b/main.nf index e4763c3f3..67ad07110 100755 --- a/main.nf +++ b/main.nf @@ -379,10 +379,17 @@ workflow { params.modules['output_documentation'] ) - // MULTIQC( - // summary, - // FASTQC.out, - // ch_multiqc_config + // /* + // * MultiQC + // */ + // workflow_summary = Schema.params_mqc_summary(summary) + // ch_workflow_summary = Channel.value(workflow_summary) + // MULTIQC ( + // ch_multiqc_config, + // ch_multiqc_custom_config.collect().ifEmpty([]), + // FASTQC.out.zip.collect().ifEmpty([]), + // //GET_SOFTWARE_VERSIONS.out.yml.collect(), + // ch_workflow_summary // ) } diff --git a/modules/nf-core/software/multiqc.nf b/modules/nf-core/software/multiqc.nf index 8280307da..bc5616be3 100755 --- a/modules/nf-core/software/multiqc.nf +++ b/modules/nf-core/software/multiqc.nf @@ -7,22 +7,6 @@ if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { custom_runName = workflow.runName } -// Channel.from(summary.collect{ [it.key, it.value] }) -// .map { k,v -> "
$k
${v ?: 'N/A'}
" } -// .reduce { a, b -> return [a, b].join("\n ") } -// .map { x -> """ -// id: 'nf-core-chipseq-summary' -// description: " - this information is collected when the pipeline is started." -// section_name: 'nf-core/chipseq Workflow Summary' -// section_href: 'https://github.com/nf-core/chipseq' -// plot_type: 'html' -// data: | -//
-// $x -//
-// """.stripIndent() } -// .set { ch_workflow_summary } - process MULTIQC { publishDir "${params.outdir}/multiqc", mode: params.publish_dir_mode From 6ff0f957c0a9c1618fec00bfe77b83edf005ee67 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Sat, 25 Jul 2020 20:32:26 +0100 Subject: [PATCH 068/538] Collect software versions --- main.nf | 74 ++++++++++++++----- .../nf-core/software/ucsc_bedgraphtobigwig.nf | 1 + modules/nf-core/subworkflow/qc_trim.nf | 6 +- 3 files changed, 58 insertions(+), 23 deletions(-) diff --git a/main.nf b/main.nf index 67ad07110..7bd3be182 100755 --- a/main.nf +++ b/main.nf @@ -275,10 +275,10 @@ workflow { params.modules['picard_collectmultiplemetrics'] ) - // PRESEQ_LCEXTRAP ( - // CLEAN_BAM.out.bam, - // params.modules['preseq_lcextrap'] - // ) + PRESEQ_LCEXTRAP ( + CLEAN_BAM.out.bam, + params.modules['preseq_lcextrap'] + ) PHANTOMPEAKQUALTOOLS ( CLEAN_BAM.out.bam, @@ -318,32 +318,39 @@ workflow { params.modules['deeptools_plotheatmap'] ) - // Join control BAM here too to generate plots with IP and CONTROL together - params.modules['deeptools_plotfingerprint'].args += " --numberOfSamples $params.fingerprint_bins" - DEEPTOOLS_PLOTFINGERPRINT ( - CLEAN_BAM.out.bam.join(CLEAN_BAM.out.bai, by: [0]), - params.modules['deeptools_plotfingerprint'] - ) - /* - * Call peaks + * Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] */ CLEAN_BAM .out .bam - .map { meta, bam -> meta.control ? null : [ meta.id, bam ] } - .set { ch_control_bam } + .join ( CLEAN_BAM.out.bai, by: [0] ) + .map { meta, bam, bai -> meta.control ? null : [ meta.id, [ bam ] , [ bai ] ] } + .set { ch_ip_control_bam } - // Create channel: [ val(meta), ip_bam, control_bam ] CLEAN_BAM .out .bam - .map { meta, bam -> meta.control ? [ meta.control, meta, bam ] : null } - .combine(ch_control_bam, by: 0) - .map { it -> [ it[1] , it[2], it[3] ] } - .set { ch_control_bam } + .join ( CLEAN_BAM.out.bai, by: [0] ) + .map { meta, bam, bai -> meta.control ? [ meta.control, meta, [ bam ], [ bai ] ] : null } + .combine(ch_ip_control_bam, by: 0) + .map { it -> [ it[1] , it[2] + it[4], it[3] + it[5] ] } + .set { ch_ip_control_bam } + + /* + * plotFingerprint for IP and control together + */ + params.modules['deeptools_plotfingerprint'].args += " --numberOfSamples $params.fingerprint_bins" + DEEPTOOLS_PLOTFINGERPRINT ( + ch_ip_control_bam, + params.modules['deeptools_plotfingerprint'] + ) if (params.macs_gsize) { + + /* + * Call peaks + */ peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' broad = params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}" pileup = params.save_macs_pileup ? '--bdg --SPMR' : '' @@ -351,8 +358,14 @@ workflow { pvalue = params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' params.modules['macs2_callpeak'].publish_dir += "/$peakType" params.modules['macs2_callpeak'].args += " $broad $pileup $fdr $pvalue" + + // Create channel: [ val(meta), ip_bam, control_bam ] + ch_ip_control_bam + .map { it -> [ it[0] , it[1][0], it[1][1] ] } + .set { ch_ip_control_bam } + MACS2_CALLPEAK ( - ch_control_bam, + ch_ip_control_bam, params.macs_gsize, params.modules['macs2_callpeak'] ) @@ -369,6 +382,27 @@ workflow { /* * Pipeline reporting */ + MAP_READS.out.bwa_version.first() + .concat( + QC_TRIM.out.fastqc_version.first().ifEmpty(null), + QC_TRIM.out.trimgalore_version.first().ifEmpty(null), + MAP_READS.out.samtools_version.first().ifEmpty(null), + MAKE_GENOME_FILTER.out.version.first().ifEmpty(null), + CLEAN_BAM.out.bamtools_version.first().ifEmpty(null), + PICARD_MERGESAMFILES.out.version.first().ifEmpty(null), + PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null), + PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null), + UCSC_BEDRAPHTOBIGWIG.out.version.first().ifEmpty(null), + DEEPTOOLS_COMPUTEMATRIX.out.version.first().ifEmpty(null), + MACS2_CALLPEAK.out.version.first().ifEmpty(null), + HOMER_ANNOTATEPEAKS.out.version.first().ifEmpty(null), + //SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null), + //MULTIQC.out.version.first().ifEmpty(null), + //echo \$(R --version 2>&1) > v_R.txt + ) + .map { it } + .set { versions } + //GET_SOFTWARE_VERSIONS ( // params.modules['get_software_versions'] //) diff --git a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf index 828dd647f..544550f35 100644 --- a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf +++ b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf @@ -23,6 +23,7 @@ process UCSC_BEDRAPHTOBIGWIG { output: tuple val(meta), path("*.bigWig"), emit: bigwig + path "*.version.txt", emit: version script: prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" diff --git a/modules/nf-core/subworkflow/qc_trim.nf b/modules/nf-core/subworkflow/qc_trim.nf index f99089a02..e2f0c6fb0 100644 --- a/modules/nf-core/subworkflow/qc_trim.nf +++ b/modules/nf-core/subworkflow/qc_trim.nf @@ -27,13 +27,13 @@ workflow QC_TRIM { trim_html = Channel.empty() trim_zip = Channel.empty() trim_log = Channel.empty() - trim_galore_version = Channel.empty() + trimgalore_version = Channel.empty() if (!skip_trimming) { TRIMGALORE(ch_reads, trim_galore_opts).reads.set { ch_trim_reads } trim_html = TRIMGALORE.out.html trim_zip = TRIMGALORE.out.zip trim_log = TRIMGALORE.out.log - trim_galore_version = TRIMGALORE.out.version + trimgalore_version = TRIMGALORE.out.version } emit: @@ -45,5 +45,5 @@ workflow QC_TRIM { trim_html // channel: [ val(meta), [ html ] ] trim_zip // channel: [ val(meta), [ zip ] ] trim_log // channel: [ val(meta), [ txt ] ] - trim_galore_version // path: *.version.txt + trimgalore_version // path: *.version.txt } From 2c5774d639f3d7e1a4a15ef6a8f35ef9c4ccd33b Mon Sep 17 00:00:00 2001 From: drpatelh Date: Sun, 26 Jul 2020 10:27:28 +0100 Subject: [PATCH 069/538] Add software versions --- main.nf | 62 ++++++++++++++++++++++++++++++++++----------------------- 1 file changed, 37 insertions(+), 25 deletions(-) diff --git a/main.nf b/main.nf index 7bd3be182..8f1455e62 100755 --- a/main.nf +++ b/main.nf @@ -200,6 +200,9 @@ workflow { ch_blacklist.ifEmpty([]), params.modules['make_genome_filter'] ) + ch_software_versions = Channel.empty() + ch_software_versions + .concat(MAKE_GENOME_FILTER.out.version.first().ifEmpty(null)) /* * Read QC & trimming @@ -213,6 +216,10 @@ workflow { params.modules['fastqc'], params.modules['trimgalore'] ) + ch_software_versions + .concat(QC_TRIM.out.fastqc_version.first().ifEmpty(null), + QC_TRIM.out.trimgalore_version.first().ifEmpty(null)) + .view() /* * Map reads & BAM QC @@ -226,6 +233,9 @@ workflow { params.modules['bwa_mem'], params.modules['samtools_sort_lib'] ) + // ch_software_versions + // .concat(MAP_READS.out.bwa_version.first(), + // MAP_READS.out.samtools_version.first().ifEmpty(null)) /* * Merge resequenced BAM files @@ -246,6 +256,8 @@ workflow { ch_sort_bam, params.modules['picard_mergesamfiles'] ) + // ch_software_versions + // .concat(PICARD_MERGESAMFILES.out.version.first().ifEmpty(null)) /* * Mark duplicates & filter BAM files @@ -265,6 +277,8 @@ workflow { params.modules['remove_bam_orphans'], params.modules['samtools_sort_filter'] ) + // ch_software_versions + // .concat(CLEAN_BAM.out.bamtools_version.first().ifEmpty(null)) /* * Post alignment QC @@ -279,11 +293,15 @@ workflow { CLEAN_BAM.out.bam, params.modules['preseq_lcextrap'] ) + // ch_software_versions + // .concat(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) PHANTOMPEAKQUALTOOLS ( CLEAN_BAM.out.bam, params.modules['phantompeakqualtools'] ) + // ch_software_versions + // .concat(PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null)) /* * Coverage tracks @@ -298,6 +316,8 @@ workflow { GET_CHROM_SIZES.out.sizes, params.modules['ucsc_bedgraphtobigwig'] ) + // ch_software_versions + // .concat(UCSC_BEDRAPHTOBIGWIG.out.version.first().ifEmpty(null)) /* * Coverage plots @@ -307,6 +327,8 @@ workflow { ch_gene_bed, params.modules['deeptools_computematrix'] ) + // ch_software_versions + // .concat(DEEPTOOLS_COMPUTEMATRIX.out.version.first().ifEmpty(null)) DEEPTOOLS_PLOTPROFILE ( DEEPTOOLS_COMPUTEMATRIX.out.matrix, @@ -369,6 +391,8 @@ workflow { params.macs_gsize, params.modules['macs2_callpeak'] ) + // ch_software_versions + // .concat(MACS2_CALLPEAK.out.version.first().ifEmpty(null)) params.modules['homer_annotatepeaks_macs2'].publish_dir += "/$peakType" HOMER_ANNOTATEPEAKS ( @@ -377,36 +401,16 @@ workflow { ch_gtf, params.modules['homer_annotatepeaks_macs2'] ) + // ch_software_versions + // .concat(HOMER_ANNOTATEPEAKS.out.version.first().ifEmpty(null)) + + // ch_software_versions + // .concat(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) } /* * Pipeline reporting */ - MAP_READS.out.bwa_version.first() - .concat( - QC_TRIM.out.fastqc_version.first().ifEmpty(null), - QC_TRIM.out.trimgalore_version.first().ifEmpty(null), - MAP_READS.out.samtools_version.first().ifEmpty(null), - MAKE_GENOME_FILTER.out.version.first().ifEmpty(null), - CLEAN_BAM.out.bamtools_version.first().ifEmpty(null), - PICARD_MERGESAMFILES.out.version.first().ifEmpty(null), - PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null), - PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null), - UCSC_BEDRAPHTOBIGWIG.out.version.first().ifEmpty(null), - DEEPTOOLS_COMPUTEMATRIX.out.version.first().ifEmpty(null), - MACS2_CALLPEAK.out.version.first().ifEmpty(null), - HOMER_ANNOTATEPEAKS.out.version.first().ifEmpty(null), - //SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null), - //MULTIQC.out.version.first().ifEmpty(null), - //echo \$(R --version 2>&1) > v_R.txt - ) - .map { it } - .set { versions } - - //GET_SOFTWARE_VERSIONS ( - // params.modules['get_software_versions'] - //) - OUTPUT_DOCUMENTATION ( ch_output_docs, ch_output_docs_images, @@ -425,6 +429,14 @@ workflow { // //GET_SOFTWARE_VERSIONS.out.yml.collect(), // ch_workflow_summary // ) + // ch_software_versions + // .concat(MULTIQC.out.version.first().ifEmpty(null)) + + //ch_software_versions.view() + // GET_SOFTWARE_VERSIONS ( + // ch_software_versions.map { it }, + // params.modules['get_software_versions'] + // ) } //////////////////////////////////////////////////// From 43f843d93f50cb74846eaa85cd55aec8869c99d6 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Sun, 26 Jul 2020 11:57:27 +0100 Subject: [PATCH 070/538] Fix getting software versions --- main.nf | 63 +++++++++++++++++++++++++++++++++------------------------ 1 file changed, 37 insertions(+), 26 deletions(-) diff --git a/main.nf b/main.nf index 8f1455e62..009b90fa9 100755 --- a/main.nf +++ b/main.nf @@ -203,6 +203,7 @@ workflow { ch_software_versions = Channel.empty() ch_software_versions .concat(MAKE_GENOME_FILTER.out.version.first().ifEmpty(null)) + .set { ch_software_versions } /* * Read QC & trimming @@ -219,7 +220,7 @@ workflow { ch_software_versions .concat(QC_TRIM.out.fastqc_version.first().ifEmpty(null), QC_TRIM.out.trimgalore_version.first().ifEmpty(null)) - .view() + .set { ch_software_versions } /* * Map reads & BAM QC @@ -233,9 +234,10 @@ workflow { params.modules['bwa_mem'], params.modules['samtools_sort_lib'] ) - // ch_software_versions - // .concat(MAP_READS.out.bwa_version.first(), - // MAP_READS.out.samtools_version.first().ifEmpty(null)) + ch_software_versions + .concat(MAP_READS.out.bwa_version.first(), + MAP_READS.out.samtools_version.first().ifEmpty(null)) + .set { ch_software_versions } /* * Merge resequenced BAM files @@ -256,8 +258,9 @@ workflow { ch_sort_bam, params.modules['picard_mergesamfiles'] ) - // ch_software_versions - // .concat(PICARD_MERGESAMFILES.out.version.first().ifEmpty(null)) + ch_software_versions + .concat(PICARD_MERGESAMFILES.out.version.first().ifEmpty(null)) + .set { ch_software_versions } /* * Mark duplicates & filter BAM files @@ -277,8 +280,9 @@ workflow { params.modules['remove_bam_orphans'], params.modules['samtools_sort_filter'] ) - // ch_software_versions - // .concat(CLEAN_BAM.out.bamtools_version.first().ifEmpty(null)) + ch_software_versions + .concat(CLEAN_BAM.out.bamtools_version.first().ifEmpty(null)) + .set { ch_software_versions } /* * Post alignment QC @@ -293,15 +297,17 @@ workflow { CLEAN_BAM.out.bam, params.modules['preseq_lcextrap'] ) - // ch_software_versions - // .concat(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) + ch_software_versions + .concat(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) + .set { ch_software_versions } PHANTOMPEAKQUALTOOLS ( CLEAN_BAM.out.bam, params.modules['phantompeakqualtools'] ) - // ch_software_versions - // .concat(PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null)) + ch_software_versions + .concat(PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null)) + .set { ch_software_versions } /* * Coverage tracks @@ -316,8 +322,9 @@ workflow { GET_CHROM_SIZES.out.sizes, params.modules['ucsc_bedgraphtobigwig'] ) - // ch_software_versions - // .concat(UCSC_BEDRAPHTOBIGWIG.out.version.first().ifEmpty(null)) + ch_software_versions + .concat(UCSC_BEDRAPHTOBIGWIG.out.version.first().ifEmpty(null)) + .set { ch_software_versions } /* * Coverage plots @@ -327,8 +334,9 @@ workflow { ch_gene_bed, params.modules['deeptools_computematrix'] ) - // ch_software_versions - // .concat(DEEPTOOLS_COMPUTEMATRIX.out.version.first().ifEmpty(null)) + ch_software_versions + .concat(DEEPTOOLS_COMPUTEMATRIX.out.version.first().ifEmpty(null)) + .set { ch_software_versions } DEEPTOOLS_PLOTPROFILE ( DEEPTOOLS_COMPUTEMATRIX.out.matrix, @@ -391,8 +399,9 @@ workflow { params.macs_gsize, params.modules['macs2_callpeak'] ) - // ch_software_versions - // .concat(MACS2_CALLPEAK.out.version.first().ifEmpty(null)) + ch_software_versions + .concat(MACS2_CALLPEAK.out.version.first().ifEmpty(null)) + .set { ch_software_versions } params.modules['homer_annotatepeaks_macs2'].publish_dir += "/$peakType" HOMER_ANNOTATEPEAKS ( @@ -401,16 +410,23 @@ workflow { ch_gtf, params.modules['homer_annotatepeaks_macs2'] ) - // ch_software_versions - // .concat(HOMER_ANNOTATEPEAKS.out.version.first().ifEmpty(null)) + ch_software_versions + .concat(HOMER_ANNOTATEPEAKS.out.version.first().ifEmpty(null)) + .set { ch_software_versions } // ch_software_versions // .concat(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) + // .set { ch_software_versions } } /* * Pipeline reporting */ + GET_SOFTWARE_VERSIONS ( + ch_software_versions.map { it }.collect(), + params.modules['get_software_versions'] + ) + OUTPUT_DOCUMENTATION ( ch_output_docs, ch_output_docs_images, @@ -431,12 +447,7 @@ workflow { // ) // ch_software_versions // .concat(MULTIQC.out.version.first().ifEmpty(null)) - - //ch_software_versions.view() - // GET_SOFTWARE_VERSIONS ( - // ch_software_versions.map { it }, - // params.modules['get_software_versions'] - // ) + // .set { ch_software_versions } } //////////////////////////////////////////////////// From d11e500464ed6658c231d7eacd25d315bff93f63 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Sun, 26 Jul 2020 12:27:26 +0100 Subject: [PATCH 071/538] Get software versions working --- bin/scrape_software_versions.py | 68 ++++--------------- main.nf | 2 +- modules/local/process/filter_bam.nf | 4 +- .../local/process/get_software_versions.nf | 38 ++++------- 4 files changed, 27 insertions(+), 85 deletions(-) diff --git a/bin/scrape_software_versions.py b/bin/scrape_software_versions.py index 6f61aa86b..e2b87c787 100755 --- a/bin/scrape_software_versions.py +++ b/bin/scrape_software_versions.py @@ -1,62 +1,18 @@ #!/usr/bin/env python from __future__ import print_function -from collections import OrderedDict -import re +import os -regexes = { - 'nf-core/chipseq': ['v_pipeline.txt', r"(\S+)"], - 'Nextflow': ['v_nextflow.txt', r"(\S+)"], - 'FastQC': ['v_fastqc.txt', r"FastQC v(\S+)"], - 'Trim Galore!': ['v_trim_galore.txt', r"version (\S+)"], - 'BWA': ['v_bwa.txt', r"Version: (\S+)"], - 'Samtools': ['v_samtools.txt', r"samtools (\S+)"], - 'BEDTools': ['v_bedtools.txt', r"bedtools v(\S+)"], - 'BamTools': ['v_bamtools.txt', r"bamtools (\S+)"], - 'deepTools': ['v_deeptools.txt', r"plotFingerprint (\S+)"], - 'Picard': ['v_picard.txt', r"\n(\S+)"], - 'R': ['v_R.txt', r"R version (\S+)"], - 'Pysam': ['v_pysam.txt', r"(\S+)"], - 'MACS2': ['v_macs2.txt', r"macs2 (\S+)"], - 'HOMER': ['v_homer.txt', r"(\S+)"], - 'featureCounts': ['v_featurecounts.txt', r"featureCounts v(\S+)"], - 'Preseq': ['v_preseq.txt', r"Version: (\S+)"], - 'MultiQC': ['v_multiqc.txt', r"multiqc, version (\S+)"], -} +results = {} +version_files = [x for x in os.listdir('.') if x.endswith('.version.txt')] +for version_file in version_files: -results = OrderedDict() -results['nf-core/chipseq'] = 'N/A' -results['Nextflow'] = 'N/A' -results['FastQC'] = 'N/A' -results['Trim Galore!'] = 'N/A' -results['BWA'] = 'N/A' -results['Samtools'] = 'N/A' -results['BEDTools'] = 'N/A' -results['BamTools'] = 'N/A' -results['deepTools'] = 'N/A' -results['Picard'] = 'N/A' -results['R'] = 'N/A' -results['Pysam'] = 'N/A' -results['MACS2'] = 'N/A' -results['HOMER'] = False -results['featureCounts'] = 'N/A' -results['Preseq'] = 'N/A' -results['MultiQC'] = 'N/A' + software = version_file.replace('.version.txt','') + if software == 'pipeline': + software = 'nf-core/chipseq' -# Search each file using its regex -for k, v in regexes.items(): - try: - with open(v[0]) as x: - versions = x.read() - match = re.search(v[1], versions) - if match: - results[k] = "v{}".format(match.group(1)) - except IOError: - results[k] = False - -# Remove software set to false in results -for k in list(results): - if not results[k]: - del(results[k]) + with open(version_file) as fin: + version = fin.read().strip() + results[software] = version # Dump to YAML print (''' @@ -68,11 +24,11 @@ data: |
''') -for k,v in results.items(): +for k,v in sorted(results.items()): print("
{}
{}
".format(k,v)) print ("
") # Write out regexes as csv file: with open('software_versions.csv', 'w') as f: - for k,v in results.items(): + for k,v in sorted(results.items()): f.write("{}\t{}\n".format(k,v)) diff --git a/main.nf b/main.nf index 009b90fa9..56c655908 100755 --- a/main.nf +++ b/main.nf @@ -442,7 +442,7 @@ workflow { // ch_multiqc_config, // ch_multiqc_custom_config.collect().ifEmpty([]), // FASTQC.out.zip.collect().ifEmpty([]), - // //GET_SOFTWARE_VERSIONS.out.yml.collect(), + // //GET_SOFTWARE_VERSIONS.out.yaml.collect(), // ch_workflow_summary // ) // ch_software_versions diff --git a/modules/local/process/filter_bam.nf b/modules/local/process/filter_bam.nf index 6302d858e..686aa7a89 100644 --- a/modules/local/process/filter_bam.nf +++ b/modules/local/process/filter_bam.nf @@ -12,7 +12,7 @@ process FILTER_BAM { else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) - + input: tuple val(meta), path(bam), path(bai) path bed @@ -39,6 +39,6 @@ process FILTER_BAM { | bamtools filter \\ -out ${prefix}.bam \\ -script $config - echo \$(bamtools --version 2>&1) > bamtools.version.txt + echo \$(bamtools --version 2>&1) | sed 's/^.*bamtools //; s/Part .*\$//' > bamtools.version.txt """ } diff --git a/modules/local/process/get_software_versions.nf b/modules/local/process/get_software_versions.nf index c946bafc0..52b45a2b4 100755 --- a/modules/local/process/get_software_versions.nf +++ b/modules/local/process/get_software_versions.nf @@ -2,39 +2,25 @@ * Parse software version numbers */ process GET_SOFTWARE_VERSIONS { - publishDir "${params.outdir}/${opts.publish_dir}", - mode: params.publish_dir_mode, - saveAs: { filename -> - if (opts.publish_results == "none") null - else if (filename.endsWith('.yaml')) null - else filename } + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else if (filename.endsWith('.yaml')) null + else filename } input: + path versions val opts output: - path 'software_versions_mqc.yaml' - path "software_versions.csv" - + path "software_versions.csv", emit: csv + path 'software_versions_mqc.yaml', emit: yaml + script: """ - echo $workflow.manifest.version > v_pipeline.txt - echo $workflow.nextflow.version > v_nextflow.txt - fastqc --version > v_fastqc.txt - trim_galore --version > v_trim_galore.txt - echo \$(bwa 2>&1) > v_bwa.txt - samtools --version > v_samtools.txt - bedtools --version > v_bedtools.txt - echo \$(bamtools --version 2>&1) > v_bamtools.txt - echo \$(plotFingerprint --version 2>&1) > v_deeptools.txt || true - picard MarkDuplicates --version &> v_picard.txt || true - echo \$(R --version 2>&1) > v_R.txt - python -c "import pysam; print(pysam.__version__)" > v_pysam.txt - echo \$(macs2 --version 2>&1) > v_macs2.txt - touch v_homer.txt - echo \$(featureCounts -v 2>&1) > v_featurecounts.txt - preseq &> v_preseq.txt - multiqc --version > v_multiqc.txt + echo $workflow.manifest.version > pipeline.version.txt + echo $workflow.nextflow.version > nextflow.version.txt scrape_software_versions.py &> software_versions_mqc.yaml """ } From 58dc14e802833d595bb2a01b5268f97b25e60eec Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 27 Jul 2020 11:53:57 +0100 Subject: [PATCH 072/538] mix instead of concat --- main.nf | 171 ++++++++++++++++---------------------------------------- 1 file changed, 48 insertions(+), 123 deletions(-) diff --git a/main.nf b/main.nf index 56c655908..1cfaf685a 100755 --- a/main.nf +++ b/main.nf @@ -201,9 +201,7 @@ workflow { params.modules['make_genome_filter'] ) ch_software_versions = Channel.empty() - ch_software_versions - .concat(MAKE_GENOME_FILTER.out.version.first().ifEmpty(null)) - .set { ch_software_versions } + ch_software_versions = ch_software_versions.mix(MAKE_GENOME_FILTER.out.version.first().ifEmpty(null)) /* * Read QC & trimming @@ -217,10 +215,8 @@ workflow { params.modules['fastqc'], params.modules['trimgalore'] ) - ch_software_versions - .concat(QC_TRIM.out.fastqc_version.first().ifEmpty(null), - QC_TRIM.out.trimgalore_version.first().ifEmpty(null)) - .set { ch_software_versions } + ch_software_versions = ch_software_versions.mix(QC_TRIM.out.fastqc_version.first().ifEmpty(null)) + ch_software_versions = ch_software_versions.mix(QC_TRIM.out.trimgalore_version.first().ifEmpty(null)) /* * Map reads & BAM QC @@ -234,10 +230,8 @@ workflow { params.modules['bwa_mem'], params.modules['samtools_sort_lib'] ) - ch_software_versions - .concat(MAP_READS.out.bwa_version.first(), - MAP_READS.out.samtools_version.first().ifEmpty(null)) - .set { ch_software_versions } + ch_software_versions = ch_software_versions.mix(MAP_READS.out.bwa_version.first()) + ch_software_versions = ch_software_versions.mix(MAP_READS.out.samtools_version.first().ifEmpty(null)) /* * Merge resequenced BAM files @@ -258,9 +252,7 @@ workflow { ch_sort_bam, params.modules['picard_mergesamfiles'] ) - ch_software_versions - .concat(PICARD_MERGESAMFILES.out.version.first().ifEmpty(null)) - .set { ch_software_versions } + ch_software_versions = ch_software_versions.mix(PICARD_MERGESAMFILES.out.version.first().ifEmpty(null)) /* * Mark duplicates & filter BAM files @@ -280,9 +272,7 @@ workflow { params.modules['remove_bam_orphans'], params.modules['samtools_sort_filter'] ) - ch_software_versions - .concat(CLEAN_BAM.out.bamtools_version.first().ifEmpty(null)) - .set { ch_software_versions } + ch_software_versions = ch_software_versions.mix(CLEAN_BAM.out.bamtools_version.first().ifEmpty(null)) /* * Post alignment QC @@ -297,17 +287,13 @@ workflow { CLEAN_BAM.out.bam, params.modules['preseq_lcextrap'] ) - ch_software_versions - .concat(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) - .set { ch_software_versions } + ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) PHANTOMPEAKQUALTOOLS ( CLEAN_BAM.out.bam, params.modules['phantompeakqualtools'] ) - ch_software_versions - .concat(PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null)) - .set { ch_software_versions } + ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null)) /* * Coverage tracks @@ -322,9 +308,7 @@ workflow { GET_CHROM_SIZES.out.sizes, params.modules['ucsc_bedgraphtobigwig'] ) - ch_software_versions - .concat(UCSC_BEDRAPHTOBIGWIG.out.version.first().ifEmpty(null)) - .set { ch_software_versions } + ch_software_versions = ch_software_versions.mix(UCSC_BEDRAPHTOBIGWIG.out.version.first().ifEmpty(null)) /* * Coverage plots @@ -334,9 +318,7 @@ workflow { ch_gene_bed, params.modules['deeptools_computematrix'] ) - ch_software_versions - .concat(DEEPTOOLS_COMPUTEMATRIX.out.version.first().ifEmpty(null)) - .set { ch_software_versions } + ch_software_versions = ch_software_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.version.first().ifEmpty(null)) DEEPTOOLS_PLOTPROFILE ( DEEPTOOLS_COMPUTEMATRIX.out.matrix, @@ -399,9 +381,7 @@ workflow { params.macs_gsize, params.modules['macs2_callpeak'] ) - ch_software_versions - .concat(MACS2_CALLPEAK.out.version.first().ifEmpty(null)) - .set { ch_software_versions } + ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.version.first().ifEmpty(null)) params.modules['homer_annotatepeaks_macs2'].publish_dir += "/$peakType" HOMER_ANNOTATEPEAKS ( @@ -410,13 +390,9 @@ workflow { ch_gtf, params.modules['homer_annotatepeaks_macs2'] ) - ch_software_versions - .concat(HOMER_ANNOTATEPEAKS.out.version.first().ifEmpty(null)) - .set { ch_software_versions } + ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS.out.version.first().ifEmpty(null)) - // ch_software_versions - // .concat(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) - // .set { ch_software_versions } + //ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) } /* @@ -433,21 +409,45 @@ workflow { params.modules['output_documentation'] ) - // /* - // * MultiQC - // */ + /* + * MultiQC + */ // workflow_summary = Schema.params_mqc_summary(summary) // ch_workflow_summary = Channel.value(workflow_summary) + // params.modules['multiqc'].publish_dir += "/$peakType" // MULTIQC ( // ch_multiqc_config, // ch_multiqc_custom_config.collect().ifEmpty([]), - // FASTQC.out.zip.collect().ifEmpty([]), - // //GET_SOFTWARE_VERSIONS.out.yaml.collect(), - // ch_workflow_summary + // GET_SOFTWARE_VERSIONS.out.yaml.collect(), + // ch_workflow_summary, + // + // QC_TRIM.out.fastqc_zip.collect { it[1] }.ifEmpty([]), + // QC_TRIM.out.trim_log.collect { it[1] }.ifEmpty([]), + // QC_TRIM.out.trim_zip.collect { it[1] }.ifEmpty([]), + // + // // MAP_READS.out.stats.collect { it[1] }, + // // MAP_READS.out.flagstat.collect { it[1] }, + // // MAP_READS.out.idxstats.collect { it[1] }, + // + // // path ('alignment/mergedLibrary/*') from ch_merge_bam_stats_mqc.collect() + // // path ('alignment/mergedLibrary/*') from ch_rm_orphan_flagstat_mqc.collect{it[1]} + // // path ('alignment/mergedLibrary/*') from ch_rm_orphan_stats_mqc.collect() + // // path ('alignment/mergedLibrary/picard_metrics/*') from ch_merge_bam_metrics_mqc.collect() + // // path ('alignment/mergedLibrary/picard_metrics/*') from ch_collectmetrics_mqc.collect() + // // + // // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) + // // path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) + // // path ('macs/consensus/*') from ch_macs_consensus_counts_mqc.collect().ifEmpty([]) + // // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) + // // + // // path ('preseq/*') from ch_preseq_mqc.collect().ifEmpty([]) + // // path ('deeptools/*') from ch_plotfingerprint_mqc.collect().ifEmpty([]) + // // path ('deeptools/*') from ch_plotprofile_mqc.collect().ifEmpty([]) + // // path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) + // // path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) + // + // params.modules['multiqc'] // ) - // ch_software_versions - // .concat(MULTIQC.out.version.first().ifEmpty(null)) - // .set { ch_software_versions } } //////////////////////////////////////////////////// @@ -735,82 +735,7 @@ workflow.onComplete { // igv_files_to_session.py igv_session.xml igv_files.txt ../../genome/${fasta.getName()} --path_prefix '../../' // """ // } -// -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// /* -- -- */ -// /* -- MULTIQC -- */ -// /* -- -- */ -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// -// Channel.from(summary.collect{ [it.key, it.value] }) -// .map { k,v -> "
$k
${v ?: 'N/A'}
" } -// .reduce { a, b -> return [a, b].join("\n ") } -// .map { x -> """ -// id: 'nf-core-chipseq-summary' -// description: " - this information is collected when the pipeline is started." -// section_name: 'nf-core/chipseq Workflow Summary' -// section_href: 'https://github.com/nf-core/chipseq' -// plot_type: 'html' -// data: | -//
-// $x -//
-// """.stripIndent() } -// .set { ch_workflow_summary } -// -// /* -// * STEP 9: MultiQC -// */ -// process MULTIQC { -// publishDir "${params.outdir}/multiqc/${PEAK_TYPE}", mode: params.publish_dir_mode -// -// when: -// !params.skip_multiqc -// -// input: -// path (multiqc_config) from ch_multiqc_config -// path (mqc_custom_config) from ch_multiqc_custom_config.collect().ifEmpty([]) -// -// path ('software_versions/*') from ch_software_versions_mqc.collect() -// path workflow_summary from ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml') -// -// path ('fastqc/*') from ch_fastqc_reports_mqc.collect().ifEmpty([]) -// path ('trimgalore/*') from ch_trimgalore_results_mqc.collect().ifEmpty([]) -// path ('trimgalore/fastqc/*') from ch_trimgalore_fastqc_reports_mqc.collect().ifEmpty([]) -// -// path ('alignment/library/*') from ch_sort_bam_flagstat_mqc.collect() -// path ('alignment/mergedLibrary/*') from ch_merge_bam_stats_mqc.collect() -// path ('alignment/mergedLibrary/*') from ch_rm_orphan_flagstat_mqc.collect{it[1]} -// path ('alignment/mergedLibrary/*') from ch_rm_orphan_stats_mqc.collect() -// path ('alignment/mergedLibrary/picard_metrics/*') from ch_merge_bam_metrics_mqc.collect() -// path ('alignment/mergedLibrary/picard_metrics/*') from ch_collectmetrics_mqc.collect() -// -// path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) -// path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) -// path ('macs/consensus/*') from ch_macs_consensus_counts_mqc.collect().ifEmpty([]) -// path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) -// -// path ('preseq/*') from ch_preseq_mqc.collect().ifEmpty([]) -// path ('deeptools/*') from ch_plotfingerprint_mqc.collect().ifEmpty([]) -// path ('deeptools/*') from ch_plotprofile_mqc.collect().ifEmpty([]) -// path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) -// path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) -// -// output: -// path '*multiqc_report.html' into ch_multiqc_report -// path '*_data' -// -// script: -// rtitle = custom_runName ? "--title \"$custom_runName\"" : '' -// rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' -// custom_config_file = params.multiqc_config ? "--config $mqc_custom_config" : '' -// """ -// multiqc . -f $rtitle $rfilename $custom_config_file -// """ -// } -// + /////////////////////////////////////////////////////////////////////////////// /////////////////////////////////////////////////////////////////////////////// /* -- -- */ From 0e00d1da87a13af6087a75111bedda0954689196 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 27 Jul 2020 12:10:19 +0100 Subject: [PATCH 073/538] toGiga to giga --- modules/nf-core/software/picard_collectmultiplemetrics.nf | 2 +- modules/nf-core/software/picard_markduplicates.nf | 2 +- modules/nf-core/software/picard_mergesamfiles.nf | 2 +- 3 files changed, 3 insertions(+), 3 deletions(-) diff --git a/modules/nf-core/software/picard_collectmultiplemetrics.nf b/modules/nf-core/software/picard_collectmultiplemetrics.nf index 8b3371c9a..3f5b1c5c3 100644 --- a/modules/nf-core/software/picard_collectmultiplemetrics.nf +++ b/modules/nf-core/software/picard_collectmultiplemetrics.nf @@ -31,7 +31,7 @@ process PICARD_COLLECTMULTIPLEMETRICS { if (!task.memory) { log.info '[Picard CollectMultipleMetrics] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' } else { - avail_mem = task.memory.toGiga() + avail_mem = task.memory.giga } """ picard \\ diff --git a/modules/nf-core/software/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf index 9636e0506..3605e9a2f 100644 --- a/modules/nf-core/software/picard_markduplicates.nf +++ b/modules/nf-core/software/picard_markduplicates.nf @@ -30,7 +30,7 @@ process PICARD_MARKDUPLICATES { if (!task.memory) { log.info '[Picard MarkDuplicates] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' } else { - avail_mem = task.memory.toGiga() + avail_mem = task.memory.giga } """ picard \\ diff --git a/modules/nf-core/software/picard_mergesamfiles.nf b/modules/nf-core/software/picard_mergesamfiles.nf index 466d767ca..76ea07ea8 100644 --- a/modules/nf-core/software/picard_mergesamfiles.nf +++ b/modules/nf-core/software/picard_mergesamfiles.nf @@ -30,7 +30,7 @@ process PICARD_MERGESAMFILES { if (!task.memory) { log.info '[Picard MergeSamFiles] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' } else { - avail_mem = task.memory.toGiga() + avail_mem = task.memory.giga } if (bam_files.size() > 1) { """ From fa41d658b70a8220a44c9f01af18d533a8aa65f8 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 27 Jul 2020 12:20:01 +0100 Subject: [PATCH 074/538] Move MultiQC module to local folder --- modules/local/process/multiqc.nf | 92 +++++++++++++++++++++++++++++ modules/nf-core/software/multiqc.nf | 40 ------------- 2 files changed, 92 insertions(+), 40 deletions(-) create mode 100755 modules/local/process/multiqc.nf delete mode 100755 modules/nf-core/software/multiqc.nf diff --git a/modules/local/process/multiqc.nf b/modules/local/process/multiqc.nf new file mode 100755 index 000000000..13453f4b1 --- /dev/null +++ b/modules/local/process/multiqc.nf @@ -0,0 +1,92 @@ +def SOFTWARE = 'multiqc' + +// Has the run name been specified by the user? +// this has the bonus effect of catching both -name and --name +custom_runName = params.name +if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { + custom_runName = workflow.runName +} + +process MULTIQC { + label 'process_medium' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else filename } + + container "quay.io/biocontainers/multiqc:1.9--pyh9f0ad1d_0" + //container "https://depot.galaxyproject.org/singularity/multiqc:1.9--pyh9f0ad1d_0" + + conda (params.conda ? "bioconda::multiqc=1.9" : null) + + input: + path multiqc_config + path mqc_custom_config + path software_versions + val workflow_summary + + path ('fastqc/*') + path ('trimgalore/*') + path ('trimgalore/fastqc/*') + + // path ('alignment/library/*') + // path ('alignment/library/*') + // path ('alignment/library/*') + + // path ('alignment/mergedLibrary/*') from ch_merge_bam_stats_mqc.collect() + // path ('alignment/mergedLibrary/*') from ch_rm_orphan_flagstat_mqc.collect{it[1]} + // path ('alignment/mergedLibrary/*') from ch_rm_orphan_stats_mqc.collect() + // path ('alignment/mergedLibrary/picard_metrics/*') from ch_merge_bam_metrics_mqc.collect() + // path ('alignment/mergedLibrary/picard_metrics/*') from ch_collectmetrics_mqc.collect() + // + // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) + // path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) + // path ('macs/consensus/*') from ch_macs_consensus_counts_mqc.collect().ifEmpty([]) + // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) + // + // path ('preseq/*') from ch_preseq_mqc.collect().ifEmpty([]) + // path ('deeptools/*') from ch_plotfingerprint_mqc.collect().ifEmpty([]) + // path ('deeptools/*') from ch_plotprofile_mqc.collect().ifEmpty([]) + // path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) + // path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) + + val opts + + output: + path "*multiqc_report.html", emit: report + path "*_data", emit: data + + script: + rtitle = custom_runName ? "--title \"$custom_runName\"" : '' + rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' + custom_config_file = params.multiqc_config ? "--config $mqc_custom_config" : '' + // TODO nf-core: Specify which MultiQC modules to use with -m for a faster run time + """ + echo '$workflow_summary' > workflow_summary_mqc.yaml + multiqc -f $opts.args $rtitle $rfilename $custom_config_file . + multiqc --version | sed -e "s/multiqc, version //g" > ${SOFTWARE}.version.txt + """ +} + +// path ('fastqc/*') from ch_fastqc_reports_mqc.collect().ifEmpty([]) +// path ('trimgalore/*') from ch_trimgalore_results_mqc.collect().ifEmpty([]) +// path ('trimgalore/fastqc/*') from ch_trimgalore_fastqc_reports_mqc.collect().ifEmpty([]) +// +// path ('alignment/library/*') from ch_sort_bam_flagstat_mqc.collect() +// path ('alignment/mergedLibrary/*') from ch_merge_bam_stats_mqc.collect() +// path ('alignment/mergedLibrary/*') from ch_rm_orphan_flagstat_mqc.collect{it[1]} +// path ('alignment/mergedLibrary/*') from ch_rm_orphan_stats_mqc.collect() +// path ('alignment/mergedLibrary/picard_metrics/*') from ch_merge_bam_metrics_mqc.collect() +// path ('alignment/mergedLibrary/picard_metrics/*') from ch_collectmetrics_mqc.collect() +// +// path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) +// path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) +// path ('macs/consensus/*') from ch_macs_consensus_counts_mqc.collect().ifEmpty([]) +// path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) +// +// path ('preseq/*') from ch_preseq_mqc.collect().ifEmpty([]) +// path ('deeptools/*') from ch_plotfingerprint_mqc.collect().ifEmpty([]) +// path ('deeptools/*') from ch_plotprofile_mqc.collect().ifEmpty([]) +// path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) +// path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) diff --git a/modules/nf-core/software/multiqc.nf b/modules/nf-core/software/multiqc.nf deleted file mode 100755 index bc5616be3..000000000 --- a/modules/nf-core/software/multiqc.nf +++ /dev/null @@ -1,40 +0,0 @@ -def SOFTWARE = 'multiqc' - -// Has the run name been specified by the user? -// this has the bonus effect of catching both -name and --name -custom_runName = params.name -if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { - custom_runName = workflow.runName -} - -process MULTIQC { - publishDir "${params.outdir}/multiqc", mode: params.publish_dir_mode - - container "quay.io/biocontainers/multiqc:1.9--pyh9f0ad1d_0" - //container "https://depot.galaxyproject.org/singularity/multiqc:1.9--pyh9f0ad1d_0" - - conda (params.conda ? "bioconda::multiqc=1.9" : null) - - input: - path (multiqc_config) from ch_multiqc_config - path (mqc_custom_config) from ch_multiqc_custom_config.collect().ifEmpty([]) - // TODO nf-core: Add in log files from your new processes for MultiQC to find! - path ('fastqc/*') from ch_fastqc_results.collect().ifEmpty([]) - path ('software_versions/*') from ch_software_versions_yaml.collect() - path workflow_summary from ch_workflow_summary.collectFile(name: "workflow_summary_mqc.yaml") - - output: - path "*multiqc_report.html" - path "*_data" - path "multiqc_plots" - - script: - rtitle = custom_runName ? "--title \"$custom_runName\"" : '' - rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' - custom_config_file = params.multiqc_config ? "--config $mqc_custom_config" : '' - // TODO nf-core: Specify which MultiQC modules to use with -m for a faster run time - """ - multiqc -f $rtitle $rfilename $custom_config_file . - multiqc --version | sed -e "s/multiqc, version //g" > ${SOFTWARE}.version.txt - """ -} From 7656b1462e91ecc9a29f8416fec84ceac34963a8 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 27 Jul 2020 12:20:16 +0100 Subject: [PATCH 075/538] Add MultiQC options --- conf/modules.config | 6 ++++++ 1 file changed, 6 insertions(+) diff --git a/conf/modules.config b/conf/modules.config index b84f21dfb..f142a10d6 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -174,5 +174,11 @@ params { publish_dir = "pipeline_info" publish_results = "all" } + 'multiqc' { + args = "" + suffix = "" + publish_dir = "multiqc" + publish_results = "all" + } } } From f1047abcbf6cc80425aa4849b072457be9a532dd Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 27 Jul 2020 13:17:29 +0100 Subject: [PATCH 076/538] Rename subworkflows to sort by file type --- conf/modules.config | 6 +- main.nf | 144 +++++++++--------- .../process/{filter_bam.nf => bam_filter.nf} | 2 +- ...e_bam_orphans.nf => bam_remove_orphans.nf} | 2 +- modules/local/process/multiqc.nf | 4 - ...ck_samplesheet.nf => samplesheet_check.nf} | 2 +- modules/local/subworkflow/bam_clean.nf | 31 ++++ modules/local/subworkflow/clean_bam.nf | 31 ---- .../{check_input.nf => input_check.nf} | 10 +- modules/nf-core/software/trimgalore.nf | 2 +- .../{sort_bam.nf => bam_sort_samtools.nf} | 16 +- .../{bam_stats.nf => bam_stats_samtools.nf} | 2 +- .../{qc_trim.nf => fastqc_trimgalore.nf} | 6 +- modules/nf-core/subworkflow/map_bwa_mem.nf | 28 ++++ modules/nf-core/subworkflow/map_reads.nf | 28 ---- ...uplicates.nf => mark_duplicates_picard.nf} | 12 +- 16 files changed, 160 insertions(+), 166 deletions(-) rename modules/local/process/{filter_bam.nf => bam_filter.nf} (95%) rename modules/local/process/{remove_bam_orphans.nf => bam_remove_orphans.nf} (93%) rename modules/local/process/{check_samplesheet.nf => samplesheet_check.nf} (98%) create mode 100644 modules/local/subworkflow/bam_clean.nf delete mode 100644 modules/local/subworkflow/clean_bam.nf rename modules/local/subworkflow/{check_input.nf => input_check.nf} (61%) rename modules/nf-core/subworkflow/{sort_bam.nf => bam_sort_samtools.nf} (54%) rename modules/nf-core/subworkflow/{bam_stats.nf => bam_stats_samtools.nf} (94%) rename modules/nf-core/subworkflow/{qc_trim.nf => fastqc_trimgalore.nf} (87%) create mode 100644 modules/nf-core/subworkflow/map_bwa_mem.nf delete mode 100644 modules/nf-core/subworkflow/map_reads.nf rename modules/nf-core/subworkflow/{mark_duplicates.nf => mark_duplicates_picard.nf} (72%) diff --git a/conf/modules.config b/conf/modules.config index f142a10d6..e3251fffb 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -5,7 +5,7 @@ */ params { modules { - 'check_samplesheet' { + 'samplesheet_check' { args = "" suffix = "" publish_dir = "pipeline_info" @@ -78,13 +78,13 @@ params { publish_dir = "bwa/mergedLibrary" publish_results = "all" } - 'filter_bam' { + 'bam_filter' { args = "" suffix = ".mLb.flT.sorted" publish_dir = "bwa/mergedLibrary" publish_results = "all" } - 'remove_bam_orphans' { + 'bam_remove_orphans' { args = "--only_fr_pairs" suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary" diff --git a/main.nf b/main.nf index 1cfaf685a..84c5cb583 100755 --- a/main.nf +++ b/main.nf @@ -141,9 +141,10 @@ include { MAKE_GENOME_FILTER } from './modules/local/process/make_genome_filt include { BEDTOOLS_GENOMECOV } from './modules/local/process/bedtools_genomecov' include { OUTPUT_DOCUMENTATION } from './modules/local/process/output_documentation' include { GET_SOFTWARE_VERSIONS } from './modules/local/process/get_software_versions' +include { MULTIQC } from './modules/local/process/multiqc' -include { CHECK_INPUT } from './modules/local/subworkflow/check_input' -include { CLEAN_BAM } from './modules/local/subworkflow/clean_bam' +include { INPUT_CHECK } from './modules/local/subworkflow/input_check' +include { BAM_CLEAN } from './modules/local/subworkflow/bam_clean' //////////////////////////////////////////////////// /* -- IMPORT NF-CORE MODULES/SUBWORKFLOWS -- */ @@ -162,13 +163,10 @@ include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/software/phant include { MACS2_CALLPEAK } from './modules/nf-core/software/macs2_callpeak' include { HOMER_ANNOTATEPEAKS } from './modules/nf-core/software/homer_annotatepeaks' //include { SUBREAD_FEATURECOUNTS } from './modules/nf-core/software/subread_featurecounts' -include { MULTIQC } from './modules/nf-core/software/multiqc' -include { QC_TRIM } from './modules/nf-core/subworkflow/qc_trim' -include { BAM_STATS } from './modules/nf-core/subworkflow/bam_stats' -include { SORT_BAM } from './modules/nf-core/subworkflow/sort_bam' -include { MAP_READS } from './modules/nf-core/subworkflow/map_reads' -include { MARK_DUPLICATES } from './modules/nf-core/subworkflow/mark_duplicates' +include { FASTQC_TRIMGALORE } from './modules/nf-core/subworkflow/fastqc_trimgalore' +include { MAP_BWA_MEM } from './modules/nf-core/subworkflow/map_bwa_mem' +include { MARK_DUPLICATES_PICARD } from './modules/nf-core/subworkflow/mark_duplicates_picard' //////////////////////////////////////////////////// /* -- RUN MAIN WORKFLOW -- */ @@ -179,10 +177,10 @@ workflow { /* * Read in samplesheet, validate and stage input files */ - CHECK_INPUT ( + INPUT_CHECK ( ch_input, params.seq_center, - params.modules['check_samplesheet'] + params.modules['samplesheet_check'] ) /* @@ -208,35 +206,35 @@ workflow { */ nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' params.modules['trimgalore'].args += nextseq - QC_TRIM ( - CHECK_INPUT.out.reads, + FASTQC_TRIMGALORE ( + INPUT_CHECK.out.reads, params.skip_fastqc, params.skip_trimming, params.modules['fastqc'], params.modules['trimgalore'] ) - ch_software_versions = ch_software_versions.mix(QC_TRIM.out.fastqc_version.first().ifEmpty(null)) - ch_software_versions = ch_software_versions.mix(QC_TRIM.out.trimgalore_version.first().ifEmpty(null)) + ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.fastqc_version.first().ifEmpty(null)) + ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.trimgalore_version.first().ifEmpty(null)) /* * Map reads & BAM QC */ score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' params.modules['bwa_mem'].args += score - MAP_READS ( - QC_TRIM.out.reads, + MAP_BWA_MEM ( + FASTQC_TRIMGALORE.out.reads, ch_index, ch_fasta, params.modules['bwa_mem'], params.modules['samtools_sort_lib'] ) - ch_software_versions = ch_software_versions.mix(MAP_READS.out.bwa_version.first()) - ch_software_versions = ch_software_versions.mix(MAP_READS.out.samtools_version.first().ifEmpty(null)) + ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.bwa_version.first()) + ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.samtools_version.first().ifEmpty(null)) /* * Merge resequenced BAM files */ - MAP_READS + MAP_BWA_MEM .out .bam .map { @@ -257,40 +255,40 @@ workflow { /* * Mark duplicates & filter BAM files */ - MARK_DUPLICATES ( + MARK_DUPLICATES_PICARD ( PICARD_MERGESAMFILES.out.bam, params.modules['picard_markduplicates'], params.modules['samtools_sort_merged_lib'] ) // Fix getting name sorted BAM here for PE/SE - CLEAN_BAM ( - MARK_DUPLICATES.out.bam.join(MARK_DUPLICATES.out.bai, by: [0]), + BAM_CLEAN ( + MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), MAKE_GENOME_FILTER.out.bed.collect(), ch_bamtools_filter_config, - params.modules['filter_bam'], - params.modules['remove_bam_orphans'], + params.modules['bam_filter'], + params.modules['bam_remove_orphans'], params.modules['samtools_sort_filter'] ) - ch_software_versions = ch_software_versions.mix(CLEAN_BAM.out.bamtools_version.first().ifEmpty(null)) + ch_software_versions = ch_software_versions.mix(BAM_CLEAN.out.bamtools_version.first().ifEmpty(null)) /* * Post alignment QC */ PICARD_COLLECTMULTIPLEMETRICS ( - CLEAN_BAM.out.bam, + BAM_CLEAN.out.bam, ch_fasta, params.modules['picard_collectmultiplemetrics'] ) - PRESEQ_LCEXTRAP ( - CLEAN_BAM.out.bam, - params.modules['preseq_lcextrap'] - ) - ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) + // PRESEQ_LCEXTRAP ( + // BAM_CLEAN.out.bam, + // params.modules['preseq_lcextrap'] + // ) + // ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) PHANTOMPEAKQUALTOOLS ( - CLEAN_BAM.out.bam, + BAM_CLEAN.out.bam, params.modules['phantompeakqualtools'] ) ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null)) @@ -299,7 +297,7 @@ workflow { * Coverage tracks */ BEDTOOLS_GENOMECOV ( - CLEAN_BAM.out.bam.join(CLEAN_BAM.out.flagstat, by: [0]), + BAM_CLEAN.out.bam.join(BAM_CLEAN.out.flagstat, by: [0]), params.modules['bedtools_genomecov'] ) @@ -333,17 +331,17 @@ workflow { /* * Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] */ - CLEAN_BAM + BAM_CLEAN .out .bam - .join ( CLEAN_BAM.out.bai, by: [0] ) + .join ( BAM_CLEAN.out.bai, by: [0] ) .map { meta, bam, bai -> meta.control ? null : [ meta.id, [ bam ] , [ bai ] ] } .set { ch_ip_control_bam } - CLEAN_BAM + BAM_CLEAN .out .bam - .join ( CLEAN_BAM.out.bai, by: [0] ) + .join ( BAM_CLEAN.out.bai, by: [0] ) .map { meta, bam, bai -> meta.control ? [ meta.control, meta, [ bam ], [ bai ] ] : null } .combine(ch_ip_control_bam, by: 0) .map { it -> [ it[1] , it[2] + it[4], it[3] + it[5] ] } @@ -412,42 +410,42 @@ workflow { /* * MultiQC */ - // workflow_summary = Schema.params_mqc_summary(summary) - // ch_workflow_summary = Channel.value(workflow_summary) - // params.modules['multiqc'].publish_dir += "/$peakType" - // MULTIQC ( - // ch_multiqc_config, - // ch_multiqc_custom_config.collect().ifEmpty([]), - // GET_SOFTWARE_VERSIONS.out.yaml.collect(), - // ch_workflow_summary, - // - // QC_TRIM.out.fastqc_zip.collect { it[1] }.ifEmpty([]), - // QC_TRIM.out.trim_log.collect { it[1] }.ifEmpty([]), - // QC_TRIM.out.trim_zip.collect { it[1] }.ifEmpty([]), - // - // // MAP_READS.out.stats.collect { it[1] }, - // // MAP_READS.out.flagstat.collect { it[1] }, - // // MAP_READS.out.idxstats.collect { it[1] }, - // - // // path ('alignment/mergedLibrary/*') from ch_merge_bam_stats_mqc.collect() - // // path ('alignment/mergedLibrary/*') from ch_rm_orphan_flagstat_mqc.collect{it[1]} - // // path ('alignment/mergedLibrary/*') from ch_rm_orphan_stats_mqc.collect() - // // path ('alignment/mergedLibrary/picard_metrics/*') from ch_merge_bam_metrics_mqc.collect() - // // path ('alignment/mergedLibrary/picard_metrics/*') from ch_collectmetrics_mqc.collect() - // // - // // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) - // // path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) - // // path ('macs/consensus/*') from ch_macs_consensus_counts_mqc.collect().ifEmpty([]) - // // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) - // // - // // path ('preseq/*') from ch_preseq_mqc.collect().ifEmpty([]) - // // path ('deeptools/*') from ch_plotfingerprint_mqc.collect().ifEmpty([]) - // // path ('deeptools/*') from ch_plotprofile_mqc.collect().ifEmpty([]) - // // path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) - // // path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) - // - // params.modules['multiqc'] - // ) + workflow_summary = Schema.params_mqc_summary(summary) + ch_workflow_summary = Channel.value(workflow_summary) + params.modules['multiqc'].publish_dir += "/$peakType" + MULTIQC ( + ch_multiqc_config, + ch_multiqc_custom_config.collect().ifEmpty([]), + GET_SOFTWARE_VERSIONS.out.yaml.collect(), + ch_workflow_summary, + + FASTQC_TRIMGALORE.out.fastqc_zip.collect { it[1] }.ifEmpty([]), + FASTQC_TRIMGALORE.out.trim_log.collect { it[1] }.ifEmpty([]), + FASTQC_TRIMGALORE.out.trim_zip.collect { it[1] }.ifEmpty([]), + + // MAP_BWA_MEM.out.stats.collect { it[1] }, + // MAP_BWA_MEM.out.flagstat.collect { it[1] }, + // MAP_BWA_MEM.out.idxstats.collect { it[1] }, + + // path ('alignment/mergedLibrary/*') from ch_merge_bam_stats_mqc.collect() + // path ('alignment/mergedLibrary/*') from ch_rm_orphan_flagstat_mqc.collect{it[1]} + // path ('alignment/mergedLibrary/*') from ch_rm_orphan_stats_mqc.collect() + // path ('alignment/mergedLibrary/picard_metrics/*') from ch_merge_bam_metrics_mqc.collect() + // path ('alignment/mergedLibrary/picard_metrics/*') from ch_collectmetrics_mqc.collect() + // + // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) + // path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) + // path ('macs/consensus/*') from ch_macs_consensus_counts_mqc.collect().ifEmpty([]) + // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) + // + // path ('preseq/*') from ch_preseq_mqc.collect().ifEmpty([]) + // path ('deeptools/*') from ch_plotfingerprint_mqc.collect().ifEmpty([]) + // path ('deeptools/*') from ch_plotprofile_mqc.collect().ifEmpty([]) + // path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) + // path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) + + params.modules['multiqc'] + ) } //////////////////////////////////////////////////// diff --git a/modules/local/process/filter_bam.nf b/modules/local/process/bam_filter.nf similarity index 95% rename from modules/local/process/filter_bam.nf rename to modules/local/process/bam_filter.nf index 686aa7a89..0dda5be2f 100644 --- a/modules/local/process/filter_bam.nf +++ b/modules/local/process/bam_filter.nf @@ -1,7 +1,7 @@ /* * Filter BAM file */ -process FILTER_BAM { +process BAM_FILTER { tag "$meta.id" label 'process_medium' publishDir "${params.outdir}/${opts.publish_dir}", diff --git a/modules/local/process/remove_bam_orphans.nf b/modules/local/process/bam_remove_orphans.nf similarity index 93% rename from modules/local/process/remove_bam_orphans.nf rename to modules/local/process/bam_remove_orphans.nf index 52a6ade92..906a75c14 100644 --- a/modules/local/process/remove_bam_orphans.nf +++ b/modules/local/process/bam_remove_orphans.nf @@ -1,7 +1,7 @@ /* * Remove orphan reads from paired-end BAM file */ -process REMOVE_BAM_ORPHANS { +process BAM_REMOVE_ORPHANS { tag "$meta.id" label 'process_medium' publishDir "${params.outdir}/${opts.publish_dir}", diff --git a/modules/local/process/multiqc.nf b/modules/local/process/multiqc.nf index 13453f4b1..fee6b9f73 100755 --- a/modules/local/process/multiqc.nf +++ b/modules/local/process/multiqc.nf @@ -69,10 +69,6 @@ process MULTIQC { """ } -// path ('fastqc/*') from ch_fastqc_reports_mqc.collect().ifEmpty([]) -// path ('trimgalore/*') from ch_trimgalore_results_mqc.collect().ifEmpty([]) -// path ('trimgalore/fastqc/*') from ch_trimgalore_fastqc_reports_mqc.collect().ifEmpty([]) -// // path ('alignment/library/*') from ch_sort_bam_flagstat_mqc.collect() // path ('alignment/mergedLibrary/*') from ch_merge_bam_stats_mqc.collect() // path ('alignment/mergedLibrary/*') from ch_rm_orphan_flagstat_mqc.collect{it[1]} diff --git a/modules/local/process/check_samplesheet.nf b/modules/local/process/samplesheet_check.nf similarity index 98% rename from modules/local/process/check_samplesheet.nf rename to modules/local/process/samplesheet_check.nf index 757453eb3..cfdb89572 100755 --- a/modules/local/process/check_samplesheet.nf +++ b/modules/local/process/samplesheet_check.nf @@ -1,7 +1,7 @@ /* * Reformat design file, check validitiy and create IP vs control mappings */ -process CHECK_SAMPLESHEET { +process SAMPLESHEET_CHECK { tag "$samplesheet" publishDir "${params.outdir}/${opts.publish_dir}", mode: params.publish_dir_mode, diff --git a/modules/local/subworkflow/bam_clean.nf b/modules/local/subworkflow/bam_clean.nf new file mode 100644 index 000000000..121a4a842 --- /dev/null +++ b/modules/local/subworkflow/bam_clean.nf @@ -0,0 +1,31 @@ +/* + * Filter BAM file + */ + +include { BAM_FILTER } from '../process/bam_filter' +include { BAM_REMOVE_ORPHANS } from '../process/bam_remove_orphans' +include { BAM_SORT_SAMTOOLS } from '../../nf-core/subworkflow/bam_sort_samtools' + +workflow BAM_CLEAN { + take: + ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] + ch_bed // channel: [ bed ] + config // file: BAMtools filter JSON config file + bam_filter_opts // map: options for bam_filter module + bam_remove_orphans_opts // map: options for bam_remove_orphans module + samtools_opts // map: options for SAMTools modules + + main: + BAM_FILTER(ch_bam_bai, ch_bed, config, bam_filter_opts) + BAM_REMOVE_ORPHANS(BAM_FILTER.out.bam, bam_remove_orphans_opts) + BAM_SORT_SAMTOOLS(BAM_REMOVE_ORPHANS.out.bam, samtools_opts) + + emit: + name_bam = BAM_REMOVE_ORPHANS.out.bam // channel: [ val(meta), [ bam ] ] + bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] + bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + bamtools_version = BAM_FILTER.out.version // path: *.version.txt +} diff --git a/modules/local/subworkflow/clean_bam.nf b/modules/local/subworkflow/clean_bam.nf deleted file mode 100644 index b51099cf1..000000000 --- a/modules/local/subworkflow/clean_bam.nf +++ /dev/null @@ -1,31 +0,0 @@ -/* - * Filter BAM file - */ - -include { FILTER_BAM } from '../process/filter_bam' -include { REMOVE_BAM_ORPHANS } from '../process/remove_bam_orphans' -include { SORT_BAM } from '../../nf-core/subworkflow/sort_bam' - -workflow CLEAN_BAM { - take: - ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] - ch_bed // channel: [ bed ] - config // file: BAMtools filter JSON config file - filter_bam_opts // map: options for filter_bam module - rm_bam_orphans_opts // map: options for remove_bam_orphans module - samtools_opts // map: options for SAMTools modules - - main: - FILTER_BAM(ch_bam_bai, ch_bed, config, filter_bam_opts) - REMOVE_BAM_ORPHANS(FILTER_BAM.out.bam, rm_bam_orphans_opts) - SORT_BAM(REMOVE_BAM_ORPHANS.out.bam, samtools_opts) - - emit: - name_bam = REMOVE_BAM_ORPHANS.out.bam // channel: [ val(meta), [ bam ] ] - bam = SORT_BAM.out.bam // channel: [ val(meta), [ bam ] ] - bai = SORT_BAM.out.bai // channel: [ val(meta), [ bai ] ] - stats = SORT_BAM.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = SORT_BAM.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = SORT_BAM.out.idxstats // channel: [ val(meta), [ idxstats ] ] - bamtools_version = FILTER_BAM.out.version // path: *.version.txt -} diff --git a/modules/local/subworkflow/check_input.nf b/modules/local/subworkflow/input_check.nf similarity index 61% rename from modules/local/subworkflow/check_input.nf rename to modules/local/subworkflow/input_check.nf index 91596732c..79b02402c 100644 --- a/modules/local/subworkflow/check_input.nf +++ b/modules/local/subworkflow/input_check.nf @@ -2,17 +2,17 @@ * Check input samplesheet and get read channels */ -include { CHECK_SAMPLESHEET; - get_samplesheet_paths } from '../process/check_samplesheet' +include { SAMPLESHEET_CHECK; + get_samplesheet_paths } from '../process/samplesheet_check' -workflow CHECK_INPUT { +workflow INPUT_CHECK { take: ch_input // file: /path/to/samplesheet.csv seq_center // string: sequencing center for read group - check_samplesheet_opts // map: options for check_samplesheet module + samplesheet_check_opts // map: options for check_samplesheet module main: - CHECK_SAMPLESHEET (ch_input, check_samplesheet_opts) + SAMPLESHEET_CHECK (ch_input, samplesheet_check_opts) .splitCsv(header:true, sep:',') .map { get_samplesheet_paths(it, seq_center) } .set { ch_reads } diff --git a/modules/nf-core/software/trimgalore.nf b/modules/nf-core/software/trimgalore.nf index ab1bd37a5..59cc12dfd 100644 --- a/modules/nf-core/software/trimgalore.nf +++ b/modules/nf-core/software/trimgalore.nf @@ -23,7 +23,7 @@ process TRIMGALORE { tuple val(meta), path("*.fq.gz"), emit: reads tuple val(meta), path("*.html"), emit: html optional true tuple val(meta), path("*.zip"), emit: zip optional true - tuple val(meta), path("*.txt"), emit: log + tuple val(meta), path("*report.txt"), emit: log path "*.version.txt", emit: version script: diff --git a/modules/nf-core/subworkflow/sort_bam.nf b/modules/nf-core/subworkflow/bam_sort_samtools.nf similarity index 54% rename from modules/nf-core/subworkflow/sort_bam.nf rename to modules/nf-core/subworkflow/bam_sort_samtools.nf index dd4f0b2c7..7efb10245 100644 --- a/modules/nf-core/subworkflow/sort_bam.nf +++ b/modules/nf-core/subworkflow/bam_sort_samtools.nf @@ -2,11 +2,11 @@ * Sort, index BAM file and run samtools stats, flagstat and idxstats */ -include { SAMTOOLS_SORT } from '../software/samtools_sort' -include { SAMTOOLS_INDEX } from '../software/samtools_index' -include { BAM_STATS } from './bam_stats' +include { SAMTOOLS_SORT } from '../software/samtools_sort' +include { SAMTOOLS_INDEX } from '../software/samtools_index' +include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' -workflow SORT_BAM { +workflow BAM_SORT_SAMTOOLS { take: ch_bam // channel: [ val(meta), [ bam ] ] samtools_opts // map: options for SAMTools modules @@ -14,13 +14,13 @@ workflow SORT_BAM { main: SAMTOOLS_SORT(ch_bam, samtools_opts) SAMTOOLS_INDEX(SAMTOOLS_SORT.out.bam, samtools_opts) - BAM_STATS(SAMTOOLS_SORT.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_opts) + BAM_STATS_SAMTOOLS(SAMTOOLS_SORT.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_opts) emit: bam = SAMTOOLS_SORT.out.bam // channel: [ val(meta), [ bam ] ] bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] - stats = BAM_STATS.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = BAM_STATS.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = BAM_STATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + stats = BAM_STATS_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_STATS_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_STATS_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] samtools_version = SAMTOOLS_SORT.out.version // path: *.version.txt } diff --git a/modules/nf-core/subworkflow/bam_stats.nf b/modules/nf-core/subworkflow/bam_stats_samtools.nf similarity index 94% rename from modules/nf-core/subworkflow/bam_stats.nf rename to modules/nf-core/subworkflow/bam_stats_samtools.nf index 95c1bb24d..5f2b6d5c7 100644 --- a/modules/nf-core/subworkflow/bam_stats.nf +++ b/modules/nf-core/subworkflow/bam_stats_samtools.nf @@ -6,7 +6,7 @@ include { SAMTOOLS_STATS } from '../software/samtools_stats' include { SAMTOOLS_IDXSTATS } from '../software/samtools_idxstats' include { SAMTOOLS_FLAGSTAT } from '../software/samtools_flagstat' -workflow BAM_STATS { +workflow BAM_STATS_SAMTOOLS { take: ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] samtools_opts // map: options for SAMTools modules diff --git a/modules/nf-core/subworkflow/qc_trim.nf b/modules/nf-core/subworkflow/fastqc_trimgalore.nf similarity index 87% rename from modules/nf-core/subworkflow/qc_trim.nf rename to modules/nf-core/subworkflow/fastqc_trimgalore.nf index e2f0c6fb0..701075771 100644 --- a/modules/nf-core/subworkflow/qc_trim.nf +++ b/modules/nf-core/subworkflow/fastqc_trimgalore.nf @@ -5,13 +5,13 @@ include { FASTQC } from '../software/fastqc' include { TRIMGALORE } from '../software/trimgalore' -workflow QC_TRIM { +workflow FASTQC_TRIMGALORE { take: ch_reads // channel: [ val(meta), [ reads ] ] skip_fastqc // boolean: true/false skip_trimming // boolean: true/false fastqc_opts // map: options for FastQC module - trim_galore_opts // map: options for TrimGalore! module + trimgalore_opts // map: options for TrimGalore! module main: fastqc_html = Channel.empty() @@ -29,7 +29,7 @@ workflow QC_TRIM { trim_log = Channel.empty() trimgalore_version = Channel.empty() if (!skip_trimming) { - TRIMGALORE(ch_reads, trim_galore_opts).reads.set { ch_trim_reads } + TRIMGALORE(ch_reads, trimgalore_opts).reads.set { ch_trim_reads } trim_html = TRIMGALORE.out.html trim_zip = TRIMGALORE.out.zip trim_log = TRIMGALORE.out.log diff --git a/modules/nf-core/subworkflow/map_bwa_mem.nf b/modules/nf-core/subworkflow/map_bwa_mem.nf new file mode 100644 index 000000000..7f0338299 --- /dev/null +++ b/modules/nf-core/subworkflow/map_bwa_mem.nf @@ -0,0 +1,28 @@ +/* + * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats + */ + +include { BWA_MEM } from '../software/bwa_mem' +include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' + +workflow MAP_BWA_MEM { + take: + ch_reads // channel: [ val(meta), [ reads ] ] + ch_index // path: /path/to/index + ch_fasta // path: /path/to/genome.fasta + bwa_mem_opts // map: options for BWA MEM module + samtools_opts // map: options for SAMTools modules + + main: + BWA_MEM(ch_reads, ch_index, ch_fasta, bwa_mem_opts) + BAM_SORT_SAMTOOLS(BWA_MEM.out.bam, samtools_opts) + + emit: + bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] + bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + bwa_version = BWA_MEM.out.version // path: *.version.txt + samtools_version = BAM_SORT_SAMTOOLS.out.samtools_version // path: *.version.txt +} diff --git a/modules/nf-core/subworkflow/map_reads.nf b/modules/nf-core/subworkflow/map_reads.nf deleted file mode 100644 index 1e310c8b0..000000000 --- a/modules/nf-core/subworkflow/map_reads.nf +++ /dev/null @@ -1,28 +0,0 @@ -/* - * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats - */ - -include { BWA_MEM } from '../software/bwa_mem' -include { SORT_BAM } from './sort_bam' - -workflow MAP_READS { - take: - ch_reads // channel: [ val(meta), [ reads ] ] - ch_index // path: /path/to/index - ch_fasta // path: /path/to/genome.fasta - bwa_mem_opts // map: options for BWA MEM module - samtools_opts // map: options for SAMTools modules - - main: - BWA_MEM(ch_reads, ch_index, ch_fasta, bwa_mem_opts) - SORT_BAM(BWA_MEM.out.bam, samtools_opts) - - emit: - bam = SORT_BAM.out.bam // channel: [ val(meta), [ bam ] ] - bai = SORT_BAM.out.bai // channel: [ val(meta), [ bai ] ] - stats = SORT_BAM.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = SORT_BAM.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = SORT_BAM.out.idxstats // channel: [ val(meta), [ idxstats ] ] - bwa_version = BWA_MEM.out.version // path: *.version.txt - samtools_version = SORT_BAM.out.samtools_version // path: *.version.txt -} diff --git a/modules/nf-core/subworkflow/mark_duplicates.nf b/modules/nf-core/subworkflow/mark_duplicates_picard.nf similarity index 72% rename from modules/nf-core/subworkflow/mark_duplicates.nf rename to modules/nf-core/subworkflow/mark_duplicates_picard.nf index 2d326a083..335a9d9a9 100644 --- a/modules/nf-core/subworkflow/mark_duplicates.nf +++ b/modules/nf-core/subworkflow/mark_duplicates_picard.nf @@ -4,9 +4,9 @@ include { PICARD_MARKDUPLICATES } from '../software/picard_markduplicates' include { SAMTOOLS_INDEX } from '../software/samtools_index' -include { BAM_STATS } from './bam_stats' +include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' -workflow MARK_DUPLICATES { +workflow MARK_DUPLICATES_PICARD { take: ch_bam // channel: [ val(meta), [ bam ] ] markduplicates_opts // map: options for picard MarkDuplicates module @@ -15,15 +15,15 @@ workflow MARK_DUPLICATES { main: PICARD_MARKDUPLICATES(ch_bam, markduplicates_opts) SAMTOOLS_INDEX(PICARD_MARKDUPLICATES.out.bam, samtools_opts) - BAM_STATS(PICARD_MARKDUPLICATES.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_opts) + BAM_STATS_SAMTOOLS(PICARD_MARKDUPLICATES.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_opts) emit: bam = PICARD_MARKDUPLICATES.out.bam // channel: [ val(meta), [ bam ] ] metrics = PICARD_MARKDUPLICATES.out.metrics // channel: [ val(meta), [ metrics ] ] bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] - stats = BAM_STATS.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = BAM_STATS.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = BAM_STATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + stats = BAM_STATS_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_STATS_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_STATS_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] picard_version = PICARD_MARKDUPLICATES.out.version // path: *.version.txt samtools_version = SAMTOOLS_INDEX.out.version // path: *.version.txt } From cab24c8e369b8b7bc71a672a211cdae9e2a535ae Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 27 Jul 2020 14:32:56 +0100 Subject: [PATCH 077/538] Get MultiQC working --- assets/multiqc_config.yaml | 13 +++-- conf/modules.config | 2 +- main.nf | 46 ++++++++------- modules/local/process/multiqc.nf | 57 +++++++------------ modules/nf-core/software/macs2_callpeak.nf | 8 +-- .../nf-core/software/picard_markduplicates.nf | 2 +- 6 files changed, 60 insertions(+), 68 deletions(-) diff --git a/assets/multiqc_config.yaml b/assets/multiqc_config.yaml index 6d5da1d66..4d795e5da 100644 --- a/assets/multiqc_config.yaml +++ b/assets/multiqc_config.yaml @@ -42,7 +42,12 @@ module_order: name: 'MERGED LIB: SAMTools (unfiltered)' info: 'This section of the report shows SAMTools results after merging libraries and before filtering.' path_filters: - - './alignment/mergedLibrary/*.mLb.mkD.sorted.bam*' + - './alignment/mergedLibrary/unfiltered/*.mLb.mkD.sorted.bam*' + - picard: + name: 'MERGED LIB: Picard (unfiltered)' + info: 'This section of the report shows picard results after merging libraries and before filtering.' + path_filters: + - './alignment/mergedLibrary/unfiltered/picard_metrics/*' - preseq: name: 'MERGED LIB: Preseq (unfiltered)' info: 'This section of the report shows Preseq results after merging libraries and before filtering.' @@ -50,12 +55,12 @@ module_order: name: 'MERGED LIB: SAMTools (filtered)' info: 'This section of the report shows SAMTools results after merging libraries and after filtering.' path_filters: - - './alignment/mergedLibrary/*.mLb.clN.sorted.bam*' + - './alignment/mergedLibrary/filtered/*.mLb.clN.sorted.bam*' - picard: - name: 'MERGED LIB: Picard' + name: 'MERGED LIB: Picard (filtered)' info: 'This section of the report shows picard results after merging libraries and after filtering.' path_filters: - - './alignment/mergedLibrary/picard_metrics/*' + - './alignment/mergedLibrary/filtered/picard_metrics/*' - deeptools: name: 'MERGED LIB: deepTools' anchor: 'mlib_deeptools' diff --git a/conf/modules.config b/conf/modules.config index e3251fffb..62bb863a5 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -68,7 +68,7 @@ params { } 'picard_markduplicates' { args = "ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" - suffix = ".mLb.mkD" + suffix = ".mLb.mkD.sorted" publish_dir = "bwa/mergedLibrary" publish_results = "all" } diff --git a/main.nf b/main.nf index 84c5cb583..5e5685453 100755 --- a/main.nf +++ b/main.nf @@ -281,11 +281,11 @@ workflow { params.modules['picard_collectmultiplemetrics'] ) - // PRESEQ_LCEXTRAP ( - // BAM_CLEAN.out.bam, - // params.modules['preseq_lcextrap'] - // ) - // ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) + PRESEQ_LCEXTRAP ( + BAM_CLEAN.out.bam, + params.modules['preseq_lcextrap'] + ) + ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) PHANTOMPEAKQUALTOOLS ( BAM_CLEAN.out.bam, @@ -417,32 +417,36 @@ workflow { ch_multiqc_config, ch_multiqc_custom_config.collect().ifEmpty([]), GET_SOFTWARE_VERSIONS.out.yaml.collect(), - ch_workflow_summary, + ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml'), FASTQC_TRIMGALORE.out.fastqc_zip.collect { it[1] }.ifEmpty([]), FASTQC_TRIMGALORE.out.trim_log.collect { it[1] }.ifEmpty([]), FASTQC_TRIMGALORE.out.trim_zip.collect { it[1] }.ifEmpty([]), - // MAP_BWA_MEM.out.stats.collect { it[1] }, - // MAP_BWA_MEM.out.flagstat.collect { it[1] }, - // MAP_BWA_MEM.out.idxstats.collect { it[1] }, + MAP_BWA_MEM.out.stats.collect { it[1] }, + MAP_BWA_MEM.out.flagstat.collect { it[1] }, + MAP_BWA_MEM.out.idxstats.collect { it[1] }, + + MARK_DUPLICATES_PICARD.out.stats.collect { it[1] }.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.flagstat.collect { it[1] }.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.idxstats.collect { it[1] }.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.metrics.collect { it[1] }.ifEmpty([]), + + BAM_CLEAN.out.stats .collect { it[1] }.ifEmpty([]), + BAM_CLEAN.out.flagstat.collect { it[1] }.ifEmpty([]), + BAM_CLEAN.out.idxstats.collect { it[1] }.ifEmpty([]), + PICARD_COLLECTMULTIPLEMETRICS.out.metrics.collect { it[1] }.ifEmpty([]), + + PRESEQ_LCEXTRAP.out.ccurve.collect { it[1] }.ifEmpty([]), + DEEPTOOLS_PLOTPROFILE.out.table.collect { it[1] }.ifEmpty([]), + DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect { it[1] }.ifEmpty([]), + // path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) + // path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) - // path ('alignment/mergedLibrary/*') from ch_merge_bam_stats_mqc.collect() - // path ('alignment/mergedLibrary/*') from ch_rm_orphan_flagstat_mqc.collect{it[1]} - // path ('alignment/mergedLibrary/*') from ch_rm_orphan_stats_mqc.collect() - // path ('alignment/mergedLibrary/picard_metrics/*') from ch_merge_bam_metrics_mqc.collect() - // path ('alignment/mergedLibrary/picard_metrics/*') from ch_collectmetrics_mqc.collect() - // // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) // path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) // path ('macs/consensus/*') from ch_macs_consensus_counts_mqc.collect().ifEmpty([]) // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) - // - // path ('preseq/*') from ch_preseq_mqc.collect().ifEmpty([]) - // path ('deeptools/*') from ch_plotfingerprint_mqc.collect().ifEmpty([]) - // path ('deeptools/*') from ch_plotprofile_mqc.collect().ifEmpty([]) - // path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) - // path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) params.modules['multiqc'] ) diff --git a/modules/local/process/multiqc.nf b/modules/local/process/multiqc.nf index fee6b9f73..16fc323d5 100755 --- a/modules/local/process/multiqc.nf +++ b/modules/local/process/multiqc.nf @@ -24,32 +24,36 @@ process MULTIQC { path multiqc_config path mqc_custom_config path software_versions - val workflow_summary + path workflow_summary path ('fastqc/*') path ('trimgalore/*') path ('trimgalore/fastqc/*') - // path ('alignment/library/*') - // path ('alignment/library/*') - // path ('alignment/library/*') + path ('alignment/library/*') + path ('alignment/library/*') + path ('alignment/library/*') - // path ('alignment/mergedLibrary/*') from ch_merge_bam_stats_mqc.collect() - // path ('alignment/mergedLibrary/*') from ch_rm_orphan_flagstat_mqc.collect{it[1]} - // path ('alignment/mergedLibrary/*') from ch_rm_orphan_stats_mqc.collect() - // path ('alignment/mergedLibrary/picard_metrics/*') from ch_merge_bam_metrics_mqc.collect() - // path ('alignment/mergedLibrary/picard_metrics/*') from ch_collectmetrics_mqc.collect() - // + path ('alignment/mergedLibrary/unfiltered/*') + path ('alignment/mergedLibrary/unfiltered/*') + path ('alignment/mergedLibrary/unfiltered/*') + path ('alignment/mergedLibrary/unfiltered/picard_metrics/*') + + path ('alignment/mergedLibrary/filtered/*') + path ('alignment/mergedLibrary/filtered/*') + path ('alignment/mergedLibrary/filtered/*') + path ('alignment/mergedLibrary/filtered/picard_metrics/*') + + path ('preseq/*') + path ('deeptools/*') + path ('deeptools/*') + // path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) + // path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) + // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) // path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) // path ('macs/consensus/*') from ch_macs_consensus_counts_mqc.collect().ifEmpty([]) // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) - // - // path ('preseq/*') from ch_preseq_mqc.collect().ifEmpty([]) - // path ('deeptools/*') from ch_plotfingerprint_mqc.collect().ifEmpty([]) - // path ('deeptools/*') from ch_plotprofile_mqc.collect().ifEmpty([]) - // path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) - // path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) val opts @@ -61,28 +65,7 @@ process MULTIQC { rtitle = custom_runName ? "--title \"$custom_runName\"" : '' rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' custom_config_file = params.multiqc_config ? "--config $mqc_custom_config" : '' - // TODO nf-core: Specify which MultiQC modules to use with -m for a faster run time """ - echo '$workflow_summary' > workflow_summary_mqc.yaml multiqc -f $opts.args $rtitle $rfilename $custom_config_file . - multiqc --version | sed -e "s/multiqc, version //g" > ${SOFTWARE}.version.txt """ } - -// path ('alignment/library/*') from ch_sort_bam_flagstat_mqc.collect() -// path ('alignment/mergedLibrary/*') from ch_merge_bam_stats_mqc.collect() -// path ('alignment/mergedLibrary/*') from ch_rm_orphan_flagstat_mqc.collect{it[1]} -// path ('alignment/mergedLibrary/*') from ch_rm_orphan_stats_mqc.collect() -// path ('alignment/mergedLibrary/picard_metrics/*') from ch_merge_bam_metrics_mqc.collect() -// path ('alignment/mergedLibrary/picard_metrics/*') from ch_collectmetrics_mqc.collect() -// -// path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) -// path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) -// path ('macs/consensus/*') from ch_macs_consensus_counts_mqc.collect().ifEmpty([]) -// path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) -// -// path ('preseq/*') from ch_preseq_mqc.collect().ifEmpty([]) -// path ('deeptools/*') from ch_plotfingerprint_mqc.collect().ifEmpty([]) -// path ('deeptools/*') from ch_plotprofile_mqc.collect().ifEmpty([]) -// path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) -// path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf index f28d6908f..8821df938 100644 --- a/modules/nf-core/software/macs2_callpeak.nf +++ b/modules/nf-core/software/macs2_callpeak.nf @@ -22,10 +22,10 @@ process MACS2_CALLPEAK { output: tuple val(meta), path("*.{narrowPeak,broadPeak}"), emit: peak - path '*.xls', emit: xls - path '*.gappedPeak', emit: gapped optional true - path '*.bed', emit: bed optional true - path '*.bdg', emit: bdg optional true + tuple val(meta), path("*.xls"), emit: xls + tuple val(meta), path("*.gappedPeak"), emit: gapped optional true + tuple val(meta), path("*.bed"), emit: bed optional true + tuple val(meta), path("*.bdg"), emit: bdg optional true path "*.version.txt", emit: version script: diff --git a/modules/nf-core/software/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf index 3605e9a2f..31c56bedd 100644 --- a/modules/nf-core/software/picard_markduplicates.nf +++ b/modules/nf-core/software/picard_markduplicates.nf @@ -21,7 +21,7 @@ process PICARD_MARKDUPLICATES { output: tuple val(meta), path("*.bam"), emit: bam - path "*.metrics.txt", emit: metrics + tuple val(meta), path("*.metrics.txt"), emit: metrics path "*.version.txt", emit: version script: From 353fbaa6ac6c0e6bd634ab00c1f27090ce1fca5a Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 27 Jul 2020 17:42:50 +0100 Subject: [PATCH 078/538] Fix spacing --- main.nf | 42 +++++++++++++++++++++--------------------- 1 file changed, 21 insertions(+), 21 deletions(-) diff --git a/main.nf b/main.nf index 5e5685453..543075cfc 100755 --- a/main.nf +++ b/main.nf @@ -419,27 +419,27 @@ workflow { GET_SOFTWARE_VERSIONS.out.yaml.collect(), ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml'), - FASTQC_TRIMGALORE.out.fastqc_zip.collect { it[1] }.ifEmpty([]), - FASTQC_TRIMGALORE.out.trim_log.collect { it[1] }.ifEmpty([]), - FASTQC_TRIMGALORE.out.trim_zip.collect { it[1] }.ifEmpty([]), - - MAP_BWA_MEM.out.stats.collect { it[1] }, - MAP_BWA_MEM.out.flagstat.collect { it[1] }, - MAP_BWA_MEM.out.idxstats.collect { it[1] }, - - MARK_DUPLICATES_PICARD.out.stats.collect { it[1] }.ifEmpty([]), - MARK_DUPLICATES_PICARD.out.flagstat.collect { it[1] }.ifEmpty([]), - MARK_DUPLICATES_PICARD.out.idxstats.collect { it[1] }.ifEmpty([]), - MARK_DUPLICATES_PICARD.out.metrics.collect { it[1] }.ifEmpty([]), - - BAM_CLEAN.out.stats .collect { it[1] }.ifEmpty([]), - BAM_CLEAN.out.flagstat.collect { it[1] }.ifEmpty([]), - BAM_CLEAN.out.idxstats.collect { it[1] }.ifEmpty([]), - PICARD_COLLECTMULTIPLEMETRICS.out.metrics.collect { it[1] }.ifEmpty([]), - - PRESEQ_LCEXTRAP.out.ccurve.collect { it[1] }.ifEmpty([]), - DEEPTOOLS_PLOTPROFILE.out.table.collect { it[1] }.ifEmpty([]), - DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect { it[1] }.ifEmpty([]), + FASTQC_TRIMGALORE.out.fastqc_zip.collect{it[1]}.ifEmpty([]), + FASTQC_TRIMGALORE.out.trim_log.collect{it[1]}.ifEmpty([]), + FASTQC_TRIMGALORE.out.trim_zip.collect{it[1]}.ifEmpty([]), + + MAP_BWA_MEM.out.stats.collect{it[1]}, + MAP_BWA_MEM.out.flagstat.collect{it[1]}, + MAP_BWA_MEM.out.idxstats.collect{it[1]}, + + MARK_DUPLICATES_PICARD.out.stats.collect{it[1]}.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.flagstat.collect{it[1]}.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.idxstats.collect{it[1]}.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.metrics.collect{it[1]}.ifEmpty([]), + + BAM_CLEAN.out.stats.collect{it[1]}.ifEmpty([]), + BAM_CLEAN.out.flagstat.collect{it[1]}.ifEmpty([]), + BAM_CLEAN.out.idxstats.collect{it[1]}.ifEmpty([]), + PICARD_COLLECTMULTIPLEMETRICS.out.metrics.collect{it[1]}.ifEmpty([]), + + PRESEQ_LCEXTRAP.out.ccurve.collect{it[1]}.ifEmpty([]), + DEEPTOOLS_PLOTPROFILE.out.table.collect{it[1]}.ifEmpty([]), + DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect{it[1]}.ifEmpty([]), // path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) // path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) From 0d22821c4ebc4e339c08d929efd6a336f3fe7f88 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 27 Jul 2020 17:43:46 +0100 Subject: [PATCH 079/538] Remove --single_end ci test --- .github/workflows/ci.yml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 1440d45b7..f8fbc404f 100755 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -61,7 +61,7 @@ jobs: NXF_ANSI_LOG: false strategy: matrix: - parameters: [--single_end, --skip_trimming, --skip_consensus_peaks] + parameters: [--skip_trimming, --skip_consensus_peaks] steps: - name: Check out pipeline code uses: actions/checkout@v2 From 8f8412c366b966f3556cb923de10a400ff0034f8 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 28 Jul 2020 13:29:23 +0100 Subject: [PATCH 080/538] Add in QC plots for peaks --- bin/{plot_macs_qc.r => plot_macs2_qc.r} | 0 conf/modules.config | 14 +++- main.nf | 74 +++++++------------ .../local/process/plot_homer_annotatepeaks.nf | 67 ++++++++--------- modules/local/process/plot_macs2_qc.nf | 66 ++++++++--------- .../nf-core/software/homer_annotatepeaks.nf | 2 +- 6 files changed, 101 insertions(+), 122 deletions(-) rename bin/{plot_macs_qc.r => plot_macs2_qc.r} (100%) diff --git a/bin/plot_macs_qc.r b/bin/plot_macs2_qc.r similarity index 100% rename from bin/plot_macs_qc.r rename to bin/plot_macs2_qc.r diff --git a/conf/modules.config b/conf/modules.config index 62bb863a5..d1aa7b919 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -156,9 +156,21 @@ params { publish_dir = "bwa/mergedLibrary/macs2" publish_results = "all" } + 'plot_macs2_qc' { + args = "-o ./ -p macs2_peak" + suffix = "" + publish_dir = "bwa/mergedLibrary/macs2" + publish_results = "all" + } 'homer_annotatepeaks_macs2' { args = "-gid" - suffix = ".mLb.clN" + suffix = "_peaks" + publish_dir = "bwa/mergedLibrary/macs2" + publish_results = "all" + } + 'plot_homer_annotatepeaks' { + args = "-o ./ -p macs2_annotatePeaks" + suffix = "" publish_dir = "bwa/mergedLibrary/macs2" publish_results = "all" } diff --git a/main.nf b/main.nf index 543075cfc..a07b5b7c4 100755 --- a/main.nf +++ b/main.nf @@ -135,16 +135,18 @@ log.info "-\033[2m----------------------------------------------------\033[0m-" /* -- IMPORT LOCAL MODULES/SUBWORKFLOWS -- */ //////////////////////////////////////////////////// -include { GTF2BED } from './modules/local/process/gtf2bed' -include { GET_CHROM_SIZES } from './modules/local/process/get_chrom_sizes' -include { MAKE_GENOME_FILTER } from './modules/local/process/make_genome_filter' -include { BEDTOOLS_GENOMECOV } from './modules/local/process/bedtools_genomecov' -include { OUTPUT_DOCUMENTATION } from './modules/local/process/output_documentation' -include { GET_SOFTWARE_VERSIONS } from './modules/local/process/get_software_versions' -include { MULTIQC } from './modules/local/process/multiqc' - -include { INPUT_CHECK } from './modules/local/subworkflow/input_check' -include { BAM_CLEAN } from './modules/local/subworkflow/bam_clean' +include { GTF2BED } from './modules/local/process/gtf2bed' +include { GET_CHROM_SIZES } from './modules/local/process/get_chrom_sizes' +include { MAKE_GENOME_FILTER } from './modules/local/process/make_genome_filter' +include { BEDTOOLS_GENOMECOV } from './modules/local/process/bedtools_genomecov' +include { PLOT_HOMER_ANNOTATEPEAKS } from './modules/local/process/plot_homer_annotatepeaks' +include { PLOT_MACS2_QC } from './modules/local/process/plot_macs2_qc' +include { OUTPUT_DOCUMENTATION } from './modules/local/process/output_documentation' +include { GET_SOFTWARE_VERSIONS } from './modules/local/process/get_software_versions' +include { MULTIQC } from './modules/local/process/multiqc' + +include { INPUT_CHECK } from './modules/local/subworkflow/input_check' +include { BAM_CLEAN } from './modules/local/subworkflow/bam_clean' //////////////////////////////////////////////////// /* -- IMPORT NF-CORE MODULES/SUBWORKFLOWS -- */ @@ -381,6 +383,13 @@ workflow { ) ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.version.first().ifEmpty(null)) + params.modules['plot_macs2_qc'].publish_dir += "/$peakType/qc" + PLOT_MACS2_QC ( + MACS2_CALLPEAK.out.peak.collect{it[1]}, + peakType, + params.modules['plot_macs2_qc'] + ) + params.modules['homer_annotatepeaks_macs2'].publish_dir += "/$peakType" HOMER_ANNOTATEPEAKS ( MACS2_CALLPEAK.out.peak, @@ -390,9 +399,17 @@ workflow { ) ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS.out.version.first().ifEmpty(null)) + params.modules['plot_homer_annotatepeaks'].publish_dir += "/$peakType/qc" + PLOT_HOMER_ANNOTATEPEAKS ( + HOMER_ANNOTATEPEAKS.out.txt.collect{it[1]}, + "_peaks.annotatePeaks.txt", + params.modules['plot_homer_annotatepeaks'] + ) + //ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) } + /* * Pipeline reporting */ @@ -466,43 +483,6 @@ workflow.onComplete { /* -- THE END -- */ //////////////////////////////////////////////////// -// /* -// * STEP 6.4: Aggregated QC plots for peaks, FRiP and peak-to-gene annotation -// */ -// process MACS2_QC { -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/qc", mode: params.publish_dir_mode -// -// when: -// params.macs_gsize && !params.skip_peak_annotation && !params.skip_peak_qc -// -// input: -// path peaks from ch_macs_qc.collect{ it[-1] } -// path annos from ch_macs_annotate.collect() -// path peak_annotation_header from ch_peak_annotation_header -// -// output: -// path '*.tsv' into ch_macs_qc_mqc -// path '*.{txt,pdf}' -// -// script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ -// """ -// plot_macs_qc.r \\ -// -i ${peaks.join(',')} \\ -// -s ${peaks.join(',').replaceAll("_peaks.${PEAK_TYPE}","")} \\ -// -o ./ \\ -// -p macs_peak -// -// plot_homer_annotatepeaks.r \\ -// -i ${annos.join(',')} \\ -// -s ${annos.join(',').replaceAll("_peaks.annotatePeaks.txt","")} \\ -// -o ./ \\ -// -p macs_annotatePeaks -// -// cat $peak_annotation_header macs_annotatePeaks.summary.txt > macs_annotatePeaks.summary_mqc.tsv -// """ -// } -// // /////////////////////////////////////////////////////////////////////////////// // /////////////////////////////////////////////////////////////////////////////// // /* -- -- */ diff --git a/modules/local/process/plot_homer_annotatepeaks.nf b/modules/local/process/plot_homer_annotatepeaks.nf index 87099c1a3..85b9274a7 100644 --- a/modules/local/process/plot_homer_annotatepeaks.nf +++ b/modules/local/process/plot_homer_annotatepeaks.nf @@ -1,37 +1,30 @@ -conda (params.conda ? "${baseDir}/environment.yml" : null) -// /* -// * STEP 6.4: Aggregated QC plots for peaks, FRiP and peak-to-gene annotation -// */ -// process MACS2_QC { -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/qc", mode: params.publish_dir_mode -// -// when: -// params.macs_gsize && !params.skip_peak_annotation && !params.skip_peak_qc -// -// input: -// path peaks from ch_macs_qc.collect{ it[-1] } -// path annos from ch_macs_annotate.collect() -// path peak_annotation_header from ch_peak_annotation_header -// -// output: -// path '*.tsv' into ch_macs_qc_mqc -// path '*.{txt,pdf}' -// -// script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ -// """ -// plot_macs_qc.r \\ -// -i ${peaks.join(',')} \\ -// -s ${peaks.join(',').replaceAll("_peaks.${PEAK_TYPE}","")} \\ -// -o ./ \\ -// -p macs_peak -// -// plot_homer_annotatepeaks.r \\ -// -i ${annos.join(',')} \\ -// -s ${annos.join(',').replaceAll("_peaks.annotatePeaks.txt","")} \\ -// -o ./ \\ -// -p macs_annotatePeaks -// -// cat $peak_annotation_header macs_annotatePeaks.summary.txt > macs_annotatePeaks.summary_mqc.tsv -// """ -// } +/* + * Aggregated QC plots for peak-to-gene annotation + */ +process PLOT_HOMER_ANNOTATEPEAKS { + label 'process_medium' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else filename } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + path annos + val suffix + val opts + + output: + path '*.txt', emit: txt + path '*.pdf', emit: pdf + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + """ + plot_homer_annotatepeaks.r \\ + -i ${annos.join(',')} \\ + -s ${annos.join(',').replaceAll("${suffix}","")} \\ + $opts.args + """ +} diff --git a/modules/local/process/plot_macs2_qc.nf b/modules/local/process/plot_macs2_qc.nf index 477c84845..51547831e 100644 --- a/modules/local/process/plot_macs2_qc.nf +++ b/modules/local/process/plot_macs2_qc.nf @@ -1,36 +1,30 @@ -// /* -// * STEP 6.4: Aggregated QC plots for peaks, FRiP and peak-to-gene annotation -// */ -// process MACS2_QC { -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/qc", mode: params.publish_dir_mode -// -// when: -// params.macs_gsize && !params.skip_peak_annotation && !params.skip_peak_qc -// -// input: -// path peaks from ch_macs_qc.collect{ it[-1] } -// path annos from ch_macs_annotate.collect() -// path peak_annotation_header from ch_peak_annotation_header -// -// output: -// path '*.tsv' into ch_macs_qc_mqc -// path '*.{txt,pdf}' -// -// script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ -// """ -// plot_macs_qc.r \\ -// -i ${peaks.join(',')} \\ -// -s ${peaks.join(',').replaceAll("_peaks.${PEAK_TYPE}","")} \\ -// -o ./ \\ -// -p macs_peak -// -// plot_homer_annotatepeaks.r \\ -// -i ${annos.join(',')} \\ -// -s ${annos.join(',').replaceAll("_peaks.annotatePeaks.txt","")} \\ -// -o ./ \\ -// -p macs_annotatePeaks -// -// cat $peak_annotation_header macs_annotatePeaks.summary.txt > macs_annotatePeaks.summary_mqc.tsv -// """ -// } +/* + * Aggregated QC plots for peaks + */ +process PLOT_MACS2_QC { + label 'process_medium' + publishDir "${params.outdir}/${opts.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else filename } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + path peaks + val peak_type + val opts + + output: + path '*.txt', emit: txt + path '*.pdf', emit: pdf + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + """ + plot_macs2_qc.r \\ + -i ${peaks.join(',')} \\ + -s ${peaks.join(',').replaceAll("_peaks.${peak_type}","")} \\ + $opts.args + """ +} diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf index 1e0a2f362..4d53de8da 100644 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ b/modules/nf-core/software/homer_annotatepeaks.nf @@ -23,7 +23,7 @@ process HOMER_ANNOTATEPEAKS { val opts output: - tuple val(meta), path("*.txt"), emit: txt + tuple val(meta), path("*annotatePeaks.txt"), emit: txt path "*.version.txt", emit: version script: From 9814f7841370b308358a5f3b6e224f26c7a90bfc Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 29 Jul 2020 12:51:44 +0100 Subject: [PATCH 081/538] Add in consensus peaks --- CHANGELOG.md | 5 + conf/modules.config | 6 + conf/test_full.config | 1 - docs/usage.md | 7 -- lib/Schema.groovy | 3 +- main.nf | 111 ++++++------------ modules/local/process/bam_filter.nf | 4 +- modules/local/process/bedtools_genomecov.nf | 2 +- .../process/{calc_frip.nf => frip_score.nf} | 0 modules/local/process/macs2_consensus.nf | 103 ++++++++-------- modules/local/process/plot_macs2_qc.nf | 2 +- modules/local/subworkflow/bam_clean.nf | 15 +-- nextflow.config | 1 - nextflow_schema.json | 7 -- 14 files changed, 112 insertions(+), 155 deletions(-) rename modules/local/process/{calc_frip.nf => frip_score.nf} (100%) diff --git a/CHANGELOG.md b/CHANGELOG.md index 37994ed80..972d6678e 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -12,10 +12,15 @@ and this project adheres to [Semantic Versioning](http://semver.org/spec/v2.0.0. ### `Fixed` +### `Removed` + +* `--single_end` parameter in favour of auto-detecting from input samplesheeet. + ### `Dependencies` * Update Nextflow `19.10.0` -> `20.07.1` + ## [1.2.0] - 2020-07-02 ### `Added` diff --git a/conf/modules.config b/conf/modules.config index d1aa7b919..25334b035 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -174,6 +174,12 @@ params { publish_dir = "bwa/mergedLibrary/macs2" publish_results = "all" } + 'macs2_consensus' { + args = "" + suffix = "" + publish_dir = "bwa/mergedLibrary/macs2" + publish_results = "all" + } 'get_software_versions' { args = "" suffix = "" diff --git a/conf/test_full.config b/conf/test_full.config index 3875f0297..fc4c61791 100755 --- a/conf/test_full.config +++ b/conf/test_full.config @@ -13,7 +13,6 @@ params { // Input data input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/design_full.csv' - single_end = true // Genome references genome = 'hg19' diff --git a/docs/usage.md b/docs/usage.md index 44d0b95ba..46c347a13 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -11,7 +11,6 @@ * [`-profile`](#-profile) * [`--input`](#--input) * [Generic arguments](#generic-arguments) - * [`--single_end`](#--single_end) * [`--seq_center`](#--seq_center) * [`--fragment_size`](#--fragment_size) * [`--fingerprint_bins`](#--fingerprint_bins) @@ -234,12 +233,6 @@ Example design files have been provided with the pipeline for [paired-end](../as ## Generic arguments -### `--single_end` - -By default, the pipeline expects paired-end data. If you have single-end data, specify `--single_end` on the command line when you launch the pipeline. - -It is not possible to run a mixture of single-end and paired-end files in one run. - ### `--seq_center` Sequencing center information that will be added to read groups in BAM files. diff --git a/lib/Schema.groovy b/lib/Schema.groovy index 3f25c88f0..ae2d2cb90 100755 --- a/lib/Schema.groovy +++ b/lib/Schema.groovy @@ -96,7 +96,6 @@ class Schema { def Map summary = [:] if (workflow.revision) summary['Pipeline Release'] = workflow.revision summary['Run Name'] = run_name ?: workflow.runName - summary['Data Type'] = params.single_end ? 'Single-End' : 'Paired-End' summary['Design File'] = params.input summary['Genome'] = params.genome ?: 'Not supplied' summary['Fasta File'] = params.fasta @@ -121,7 +120,7 @@ class Schema { summary['NextSeq Trim'] = "$params.trim_nextseq bp" } if (params.seq_center) summary['Sequencing Center'] = params.seq_center - if (params.single_end) summary['Fragment Size'] = "$params.fragment_size bp" + summary['Fragment Size'] = "$params.fragment_size bp" summary['Fingerprint Bins'] = params.fingerprint_bins if (params.keep_dups) summary['Keep Duplicates'] = 'Yes' if (params.keep_multi_map) summary['Keep Multi-mapped'] = 'Yes' diff --git a/main.nf b/main.nf index a07b5b7c4..63d95c727 100755 --- a/main.nf +++ b/main.nf @@ -97,11 +97,9 @@ ch_output_docs = file("$baseDir/docs/output.md", checkIfExists: true) ch_output_docs_images = file("$baseDir/docs/images/", checkIfExists: true) // JSON files required by BAMTools for alignment filtering -if (params.single_end) { - ch_bamtools_filter_config = file(params.bamtools_filter_se_config, checkIfExists: true) -} else { - ch_bamtools_filter_config = file(params.bamtools_filter_pe_config, checkIfExists: true) -} +ch_bamtools_filter_se_config = file(params.bamtools_filter_se_config, checkIfExists: true) +ch_bamtools_filter_pe_config = file(params.bamtools_filter_pe_config, checkIfExists: true) +//ch_bamtools_filter_config // Header files for MultiQC ch_peak_count_header = file("$baseDir/assets/multiqc/peak_count_header.txt", checkIfExists: true) @@ -141,6 +139,8 @@ include { MAKE_GENOME_FILTER } from './modules/local/process/make_genome_f include { BEDTOOLS_GENOMECOV } from './modules/local/process/bedtools_genomecov' include { PLOT_HOMER_ANNOTATEPEAKS } from './modules/local/process/plot_homer_annotatepeaks' include { PLOT_MACS2_QC } from './modules/local/process/plot_macs2_qc' +include { MACS2_CONSENSUS } from './modules/local/process/macs2_consensus' +// include { FRIP_SCORE } from './modules/local/process/frip_score' include { OUTPUT_DOCUMENTATION } from './modules/local/process/output_documentation' include { GET_SOFTWARE_VERSIONS } from './modules/local/process/get_software_versions' include { MULTIQC } from './modules/local/process/multiqc' @@ -193,10 +193,7 @@ workflow { if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf, params.modules['gtf2bed'] ) } MAKE_GENOME_FILTER ( - GET_CHROM_SIZES ( - ch_fasta, - params.modules['get_chrom_sizes'] - ).sizes, + GET_CHROM_SIZES ( ch_fasta, params.modules['get_chrom_sizes'] ).sizes, ch_blacklist.ifEmpty([]), params.modules['make_genome_filter'] ) @@ -267,7 +264,8 @@ workflow { BAM_CLEAN ( MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), MAKE_GENOME_FILTER.out.bed.collect(), - ch_bamtools_filter_config, + ch_bamtools_filter_se_config, + ch_bamtools_filter_pe_config, params.modules['bam_filter'], params.modules['bam_remove_orphans'], params.modules['samtools_sort_filter'] @@ -386,7 +384,6 @@ workflow { params.modules['plot_macs2_qc'].publish_dir += "/$peakType/qc" PLOT_MACS2_QC ( MACS2_CALLPEAK.out.peak.collect{it[1]}, - peakType, params.modules['plot_macs2_qc'] ) @@ -406,6 +403,33 @@ workflow { params.modules['plot_homer_annotatepeaks'] ) + // Create channel: [ meta , [ peaks ] ] + // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] + MACS2_CALLPEAK + .out + .peak + .map { meta, peak -> [ meta.antibody , meta.id.split('_')[0..-2].join('_'), peak ] } + .groupTuple() + .map { + antibody, groups, peaks -> + [ antibody, + groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, + peaks ] } + .map { + antibody, groups, peaks -> + def meta = [:] + meta.id = antibody + meta.multiple_groups = groups.size() > 1 + meta.replicates_exist = groups.max { groups.value }.value > 1 + [ meta, peaks ] } + .set { ch_antibody_peaks } + + params.modules['macs2_consensus'].publish_dir += "/$peakType/consensus" + MACS2_CONSENSUS ( + ch_antibody_peaks, + params.modules['macs2_consensus'] + ) + //ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) } @@ -483,71 +507,6 @@ workflow.onComplete { /* -- THE END -- */ //////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// /* -- -- */ -// /* -- CONSENSUS PEAKS ANALYSIS -- */ -// /* -- -- */ -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// -// // Group by ip from this point and carry forward boolean variables -// ch_macs_consensus -// .map { it -> [ it[0], it[1], it[2], it[-1] ] } -// .groupTuple() -// .map { it -> [ it[0], it[1][0], it[2][0], it[3].sort() ] } -// .set { ch_macs_consensus } -// -// /* -// * STEP 7.1: Consensus peaks across samples, create boolean filtering file, SAF file for featureCounts and UpSetR plot for intersection -// */ -// process CONSENSUS_PEAKS { -// tag "${antibody}" -// label 'process_long' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (filename.endsWith('.igv.txt')) null -// else filename -// } -// -// when: -// params.macs_gsize && (replicatesExist || multipleGroups) && !params.skip_consensus_peaks -// -// input: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(peaks) from ch_macs_consensus -// -// output: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), path('*.bed') into ch_macs_consensus_bed -// tuple val(antibody), path('*.saf') into ch_macs_consensus_saf -// path '*.boolean.txt' into ch_macs_consensus_bool -// path '*igv.txt' into ch_macs_consensus_igv -// path '*.intersect.{txt,plot.pdf}' -// -// script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ -// prefix = "${antibody}.consensus_peaks" -// mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') -// collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') -// expandparam = params.narrow_peak ? '--is_narrow_peak' : '' -// """ -// sort -T '.' -k1,1 -k2,2n ${peaks.collect{it.toString()}.sort().join(' ')} \\ -// | mergeBed -c $mergecols -o $collapsecols > ${prefix}.txt -// -// macs2_merged_expand.py ${prefix}.txt \\ -// ${peaks.collect{it.toString()}.sort().join(',').replaceAll("_peaks.${PEAK_TYPE}","")} \\ -// ${prefix}.boolean.txt \\ -// --min_replicates $params.min_reps_consensus \\ -// $expandparam -// -// awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$1, \$2, \$3, \$4, "0", "+" }' ${prefix}.boolean.txt > ${prefix}.bed -// -// echo -e "GeneID\tChr\tStart\tEnd\tStrand" > ${prefix}.saf -// awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$4, \$1, \$2, \$3, "+" }' ${prefix}.boolean.txt >> ${prefix}.saf -// -// plot_peak_intersect.r -i ${prefix}.boolean.intersect.txt -o ${prefix}.boolean.intersect.plot.pdf -// -// find * -type f -name "${prefix}.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/"{}"\\t0,0,0" \\; > ${prefix}.bed.igv.txt -// """ -// } // // /* // * STEP 7.2: Annotate consensus peaks with HOMER, and add annotation to boolean output file diff --git a/modules/local/process/bam_filter.nf b/modules/local/process/bam_filter.nf index 0dda5be2f..7a9056d44 100644 --- a/modules/local/process/bam_filter.nf +++ b/modules/local/process/bam_filter.nf @@ -16,7 +16,8 @@ process BAM_FILTER { input: tuple val(meta), path(bam), path(bai) path bed - path config + path bamtools_filter_se_config + path bamtools_filter_pe_config val opts output: @@ -29,6 +30,7 @@ process BAM_FILTER { dup_params = params.keep_dups ? '' : '-F 0x0400' multimap_params = params.keep_multi_map ? '' : '-q 1' blacklist_params = params.blacklist ? "-L $bed" : '' + config = meta.single_end ? bamtools_filter_se_config : bamtools_filter_pe_config """ samtools view \\ $filter_params \\ diff --git a/modules/local/process/bedtools_genomecov.nf b/modules/local/process/bedtools_genomecov.nf index b167d11fc..f00426105 100644 --- a/modules/local/process/bedtools_genomecov.nf +++ b/modules/local/process/bedtools_genomecov.nf @@ -27,7 +27,7 @@ process BEDTOOLS_GENOMECOV { script: prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" pe = meta.single_end ? '' : '-pc' - extend = (params.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' + extend = (meta.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' """ SCALE_FACTOR=\$(grep 'mapped (' $flagstat | awk '{print 1000000/\$1}') echo \$SCALE_FACTOR > ${prefix}.scale_factor.txt diff --git a/modules/local/process/calc_frip.nf b/modules/local/process/frip_score.nf similarity index 100% rename from modules/local/process/calc_frip.nf rename to modules/local/process/frip_score.nf diff --git a/modules/local/process/macs2_consensus.nf b/modules/local/process/macs2_consensus.nf index 134a9857f..55772aba4 100644 --- a/modules/local/process/macs2_consensus.nf +++ b/modules/local/process/macs2_consensus.nf @@ -1,51 +1,52 @@ -// conda (params.conda ? "${baseDir}/environment.yml" : null) -// /* -// * STEP 7.1: Consensus peaks across samples, create boolean filtering file, SAF file for featureCounts and UpSetR plot for intersection -// */ -// process CONSENSUS_PEAKS { -// tag "${antibody}" -// label 'process_long' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (filename.endsWith('.igv.txt')) null -// else filename -// } -// -// when: -// params.macs_gsize && (replicatesExist || multipleGroups) && !params.skip_consensus_peaks -// -// input: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(peaks) from ch_macs_consensus -// -// output: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), path('*.bed') into ch_macs_consensus_bed -// tuple val(antibody), path('*.saf') into ch_macs_consensus_saf -// path '*.boolean.txt' into ch_macs_consensus_bool -// path '*igv.txt' into ch_macs_consensus_igv -// path '*.intersect.{txt,plot.pdf}' -// -// script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ -// prefix = "${antibody}.consensus_peaks" -// mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') -// collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') -// expandparam = params.narrow_peak ? '--is_narrow_peak' : '' -// """ -// sort -T '.' -k1,1 -k2,2n ${peaks.collect{it.toString()}.sort().join(' ')} \\ -// | mergeBed -c $mergecols -o $collapsecols > ${prefix}.txt -// -// macs2_merged_expand.py ${prefix}.txt \\ -// ${peaks.collect{it.toString()}.sort().join(',').replaceAll("_peaks.${PEAK_TYPE}","")} \\ -// ${prefix}.boolean.txt \\ -// --min_replicates $params.min_reps_consensus \\ -// $expandparam -// -// awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$1, \$2, \$3, \$4, "0", "+" }' ${prefix}.boolean.txt > ${prefix}.bed -// -// echo -e "GeneID\tChr\tStart\tEnd\tStrand" > ${prefix}.saf -// awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$4, \$1, \$2, \$3, "+" }' ${prefix}.boolean.txt >> ${prefix}.saf -// -// plot_peak_intersect.r -i ${prefix}.boolean.intersect.txt -o ${prefix}.boolean.intersect.plot.pdf -// -// find * -type f -name "${prefix}.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/"{}"\\t0,0,0" \\; > ${prefix}.bed.igv.txt -// """ -// } +/* + * Consensus peaks across samples, create boolean filtering file, SAF file for featureCounts + */ +process MACS2_CONSENSUS { + tag "$meta.id" + label 'process_long' + publishDir "${params.outdir}/${opts.publish_dir}/${meta.id}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (opts.publish_results == "none") null + else filename } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + tuple val(meta), path(peaks) + val opts + + output: + tuple val(meta), path("*.bed"), emit: bed + tuple val(meta), path("*.saf"), emit: saf + tuple val(meta), path("*.pdf"), emit: pdf + tuple val(meta), path("*.boolean.txt"), emit: boolean_txt + tuple val(meta), path("*.intersect.txt"), emit: intersect_txt + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + if (meta.multiple_groups || meta.replicates_exist) { + prefix = opts.suffix ? "${meta.id}${opts.suffix}.consensus_peaks" : "${meta.id}.consensus_peaks" + peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' + mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') + collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') + expandparam = params.narrow_peak ? '--is_narrow_peak' : '' + """ + sort -T '.' -k1,1 -k2,2n ${peaks.collect{it.toString()}.sort().join(' ')} \\ + | mergeBed -c $mergecols -o $collapsecols > ${prefix}.txt + + macs2_merged_expand.py \\ + ${prefix}.txt \\ + ${peaks.collect{it.toString()}.sort().join(',').replaceAll("_peaks.${peak_type}","")} \\ + ${prefix}.boolean.txt \\ + --min_replicates $params.min_reps_consensus \\ + $expandparam + + awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$1, \$2, \$3, \$4, "0", "+" }' ${prefix}.boolean.txt > ${prefix}.bed + + echo -e "GeneID\tChr\tStart\tEnd\tStrand" > ${prefix}.saf + awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$4, \$1, \$2, \$3, "+" }' ${prefix}.boolean.txt >> ${prefix}.saf + + plot_peak_intersect.r -i ${prefix}.boolean.intersect.txt -o ${prefix}.boolean.intersect.plot.pdf + """ + } +} diff --git a/modules/local/process/plot_macs2_qc.nf b/modules/local/process/plot_macs2_qc.nf index 51547831e..a44737e50 100644 --- a/modules/local/process/plot_macs2_qc.nf +++ b/modules/local/process/plot_macs2_qc.nf @@ -13,7 +13,6 @@ process PLOT_MACS2_QC { input: path peaks - val peak_type val opts output: @@ -21,6 +20,7 @@ process PLOT_MACS2_QC { path '*.pdf', emit: pdf script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' """ plot_macs2_qc.r \\ -i ${peaks.join(',')} \\ diff --git a/modules/local/subworkflow/bam_clean.nf b/modules/local/subworkflow/bam_clean.nf index 121a4a842..0b79b5969 100644 --- a/modules/local/subworkflow/bam_clean.nf +++ b/modules/local/subworkflow/bam_clean.nf @@ -8,15 +8,16 @@ include { BAM_SORT_SAMTOOLS } from '../../nf-core/subworkflow/bam_sort_samtools workflow BAM_CLEAN { take: - ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] - ch_bed // channel: [ bed ] - config // file: BAMtools filter JSON config file - bam_filter_opts // map: options for bam_filter module - bam_remove_orphans_opts // map: options for bam_remove_orphans module - samtools_opts // map: options for SAMTools modules + ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] + ch_bed // channel: [ bed ] + bamtools_filter_se_config // file: BAMtools filter JSON config file for SE data + bamtools_filter_pe_config // file: BAMtools filter JSON config file for PE data + bam_filter_opts // map: options for bam_filter module + bam_remove_orphans_opts // map: options for bam_remove_orphans module + samtools_opts // map: options for SAMTools modules main: - BAM_FILTER(ch_bam_bai, ch_bed, config, bam_filter_opts) + BAM_FILTER(ch_bam_bai, ch_bed, bamtools_filter_se_config, bamtools_filter_pe_config, bam_filter_opts) BAM_REMOVE_ORPHANS(BAM_FILTER.out.bam, bam_remove_orphans_opts) BAM_SORT_SAMTOOLS(BAM_REMOVE_ORPHANS.out.bam, samtools_opts) diff --git a/nextflow.config b/nextflow.config index fe2bcc264..b86c42e50 100644 --- a/nextflow.config +++ b/nextflow.config @@ -10,7 +10,6 @@ params { // Options: Generic input = './design.csv' - single_end = false seq_center = '' fragment_size = 200 fingerprint_bins = 500000 diff --git a/nextflow_schema.json b/nextflow_schema.json index 1d0dfff29..d73ac61a5 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -14,13 +14,6 @@ "help_text": "You will need to create a design file with information about the samples in your experiment before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 4 columns, and a header row. See [usage docs](https://nf-co.re/atacseq/docs/usage#--input).", "fa_icon": "fas fa-file-csv" }, - "single_end": { - "type": "boolean", - "description": "Specifies that the input is single-end reads.", - "fa_icon": "fas fa-align-center", - "default": false, - "help_text": "By default, the pipeline expects paired-end data. If you have single-end data, specify this parameter on the command line when you launch the pipeline. It is not possible to run a mixture of single-end and paired-end files in one run." - }, "fragment_size": { "type": "integer", "default": 0, From eeeb20573a5153d7e94e649f04321f235f001a01 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 29 Jul 2020 13:29:34 +0100 Subject: [PATCH 082/538] Replace opts with options --- modules/local/process/bam_filter.nf | 8 ++++---- modules/local/process/bam_remove_orphans.nf | 12 ++++++------ modules/local/process/bedtools_genomecov.nf | 8 ++++---- modules/local/process/get_chrom_sizes.nf | 6 +++--- modules/local/process/get_software_versions.nf | 8 ++++---- modules/local/process/gtf2bed.nf | 6 +++--- modules/local/process/macs2_consensus.nf | 8 ++++---- modules/local/process/make_genome_filter.nf | 6 +++--- modules/local/process/multiqc.nf | 10 +++++----- modules/local/process/output_documentation.nf | 6 +++--- modules/local/process/plot_homer_annotatepeaks.nf | 8 ++++---- modules/local/process/plot_macs2_qc.nf | 8 ++++---- modules/local/process/samplesheet_check.nf | 6 +++--- modules/local/subworkflow/bam_clean.nf | 12 ++++++------ modules/local/subworkflow/input_check.nf | 8 ++++---- modules/nf-core/software/bwa_index.nf | 8 ++++---- modules/nf-core/software/bwa_mem.nf | 14 +++++++------- .../nf-core/software/deeptools_computematrix.nf | 10 +++++----- .../nf-core/software/deeptools_plotfingerprint.nf | 10 +++++----- modules/nf-core/software/deeptools_plotheatmap.nf | 10 +++++----- modules/nf-core/software/deeptools_plotprofile.nf | 10 +++++----- modules/nf-core/software/fastqc.nf | 12 ++++++------ modules/nf-core/software/homer_annotatepeaks.nf | 10 +++++----- modules/nf-core/software/macs2_callpeak.nf | 10 +++++----- modules/nf-core/software/phantompeakqualtools.nf | 8 ++++---- .../software/picard_collectmultiplemetrics.nf | 10 +++++----- modules/nf-core/software/picard_markduplicates.nf | 10 +++++----- modules/nf-core/software/picard_mergesamfiles.nf | 10 +++++----- modules/nf-core/software/preseq_lcextrap.nf | 12 ++++++------ modules/nf-core/software/samtools_flagstat.nf | 6 +++--- modules/nf-core/software/samtools_idxstats.nf | 6 +++--- modules/nf-core/software/samtools_index.nf | 6 +++--- modules/nf-core/software/samtools_sort.nf | 10 +++++----- modules/nf-core/software/samtools_stats.nf | 6 +++--- modules/nf-core/software/trimgalore.nf | 12 ++++++------ modules/nf-core/software/ucsc_bedgraphtobigwig.nf | 8 ++++---- modules/nf-core/subworkflow/bam_sort_samtools.nf | 10 +++++----- modules/nf-core/subworkflow/bam_stats_samtools.nf | 10 +++++----- modules/nf-core/subworkflow/fastqc_trimgalore.nf | 14 +++++++------- modules/nf-core/subworkflow/map_bwa_mem.nf | 14 +++++++------- .../nf-core/subworkflow/mark_duplicates_picard.nf | 12 ++++++------ 41 files changed, 189 insertions(+), 189 deletions(-) diff --git a/modules/local/process/bam_filter.nf b/modules/local/process/bam_filter.nf index 7a9056d44..df4e9e90b 100644 --- a/modules/local/process/bam_filter.nf +++ b/modules/local/process/bam_filter.nf @@ -4,10 +4,10 @@ process BAM_FILTER { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -18,14 +18,14 @@ process BAM_FILTER { path bed path bamtools_filter_se_config path bamtools_filter_pe_config - val opts + val options output: tuple val(meta), path("*.bam"), emit: bam path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" filter_params = meta.single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' dup_params = params.keep_dups ? '' : '-F 0x0400' multimap_params = params.keep_multi_map ? '' : '-q 1' diff --git a/modules/local/process/bam_remove_orphans.nf b/modules/local/process/bam_remove_orphans.nf index 906a75c14..6aa109a4e 100644 --- a/modules/local/process/bam_remove_orphans.nf +++ b/modules/local/process/bam_remove_orphans.nf @@ -4,27 +4,27 @@ process BAM_REMOVE_ORPHANS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) - + input: tuple val(meta), path(bam) - val opts + val options output: tuple val(meta), path("${prefix}.bam"), emit: bam script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" if (!meta.single_end) { """ samtools sort -n -@ $task.cpus -o ${prefix}.name.sorted.bam -T ${prefix}.name.sorted $bam - bampe_rm_orphan.py ${prefix}.name.sorted.bam ${prefix}.bam $opts.args + bampe_rm_orphan.py ${prefix}.name.sorted.bam ${prefix}.bam $options.args """ } else { """ diff --git a/modules/local/process/bedtools_genomecov.nf b/modules/local/process/bedtools_genomecov.nf index f00426105..5a97667d4 100644 --- a/modules/local/process/bedtools_genomecov.nf +++ b/modules/local/process/bedtools_genomecov.nf @@ -3,10 +3,10 @@ def SOFTWARE = 'bedtools' process BEDTOOLS_GENOMECOV { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -17,7 +17,7 @@ process BEDTOOLS_GENOMECOV { input: tuple val(meta), path(bam), path(flagstat) - val opts + val options output: tuple val(meta), path("*.bedGraph"), emit: bedgraph @@ -25,7 +25,7 @@ process BEDTOOLS_GENOMECOV { path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" pe = meta.single_end ? '' : '-pc' extend = (meta.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' """ diff --git a/modules/local/process/get_chrom_sizes.nf b/modules/local/process/get_chrom_sizes.nf index b90e23ab1..9424b046e 100644 --- a/modules/local/process/get_chrom_sizes.nf +++ b/modules/local/process/get_chrom_sizes.nf @@ -5,10 +5,10 @@ def SOFTWARE = 'samtools' */ process GET_CHROM_SIZES { tag "$fasta" - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else filename } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" @@ -18,7 +18,7 @@ process GET_CHROM_SIZES { input: path fasta - val opts + val options output: path '*.sizes', emit: sizes diff --git a/modules/local/process/get_software_versions.nf b/modules/local/process/get_software_versions.nf index 52b45a2b4..3dff31d87 100755 --- a/modules/local/process/get_software_versions.nf +++ b/modules/local/process/get_software_versions.nf @@ -2,21 +2,21 @@ * Parse software version numbers */ process GET_SOFTWARE_VERSIONS { - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.yaml')) null else filename } input: path versions - val opts + val options output: path "software_versions.csv", emit: csv path 'software_versions_mqc.yaml', emit: yaml - + script: """ echo $workflow.manifest.version > pipeline.version.txt diff --git a/modules/local/process/gtf2bed.nf b/modules/local/process/gtf2bed.nf index 9abce96e6..a10b57102 100644 --- a/modules/local/process/gtf2bed.nf +++ b/modules/local/process/gtf2bed.nf @@ -4,10 +4,10 @@ process GTF2BED { tag "$gtf" label 'process_low' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else filename } container "quay.io/biocontainers/perl:5.26.2" @@ -17,7 +17,7 @@ process GTF2BED { input: path gtf - val opts + val options output: path '*.bed' diff --git a/modules/local/process/macs2_consensus.nf b/modules/local/process/macs2_consensus.nf index 55772aba4..8abb2c515 100644 --- a/modules/local/process/macs2_consensus.nf +++ b/modules/local/process/macs2_consensus.nf @@ -4,17 +4,17 @@ process MACS2_CONSENSUS { tag "$meta.id" label 'process_long' - publishDir "${params.outdir}/${opts.publish_dir}/${meta.id}", + publishDir "${params.outdir}/${options.publish_dir}/${meta.id}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) input: tuple val(meta), path(peaks) - val opts + val options output: tuple val(meta), path("*.bed"), emit: bed @@ -25,7 +25,7 @@ process MACS2_CONSENSUS { script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ if (meta.multiple_groups || meta.replicates_exist) { - prefix = opts.suffix ? "${meta.id}${opts.suffix}.consensus_peaks" : "${meta.id}.consensus_peaks" + prefix = options.suffix ? "${meta.id}${options.suffix}.consensus_peaks" : "${meta.id}.consensus_peaks" peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') diff --git a/modules/local/process/make_genome_filter.nf b/modules/local/process/make_genome_filter.nf index 59addb3e4..bc9b5a98f 100644 --- a/modules/local/process/make_genome_filter.nf +++ b/modules/local/process/make_genome_filter.nf @@ -5,10 +5,10 @@ def SOFTWARE = 'bedtools' */ process MAKE_GENOME_FILTER { tag "$sizes" - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else filename } container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" @@ -19,7 +19,7 @@ process MAKE_GENOME_FILTER { input: path sizes path blacklist - val opts + val options output: path '*.bed', emit: bed diff --git a/modules/local/process/multiqc.nf b/modules/local/process/multiqc.nf index 16fc323d5..513886bb9 100755 --- a/modules/local/process/multiqc.nf +++ b/modules/local/process/multiqc.nf @@ -9,10 +9,10 @@ if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { process MULTIQC { label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else filename } container "quay.io/biocontainers/multiqc:1.9--pyh9f0ad1d_0" @@ -49,13 +49,13 @@ process MULTIQC { path ('deeptools/*') // path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) // path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) - + // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) // path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) // path ('macs/consensus/*') from ch_macs_consensus_counts_mqc.collect().ifEmpty([]) // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) - val opts + val options output: path "*multiqc_report.html", emit: report @@ -66,6 +66,6 @@ process MULTIQC { rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' custom_config_file = params.multiqc_config ? "--config $mqc_custom_config" : '' """ - multiqc -f $opts.args $rtitle $rfilename $custom_config_file . + multiqc -f $options.args $rtitle $rfilename $custom_config_file . """ } diff --git a/modules/local/process/output_documentation.nf b/modules/local/process/output_documentation.nf index 39332b811..0f8cecd5c 100755 --- a/modules/local/process/output_documentation.nf +++ b/modules/local/process/output_documentation.nf @@ -2,10 +2,10 @@ * Output Markdown documentation to HTML */ process OUTPUT_DOCUMENTATION { - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -13,7 +13,7 @@ process OUTPUT_DOCUMENTATION { input: path output_docs path images - val opts + val options output: path "results_description.html" diff --git a/modules/local/process/plot_homer_annotatepeaks.nf b/modules/local/process/plot_homer_annotatepeaks.nf index 85b9274a7..b2e25bd87 100644 --- a/modules/local/process/plot_homer_annotatepeaks.nf +++ b/modules/local/process/plot_homer_annotatepeaks.nf @@ -3,10 +3,10 @@ */ process PLOT_HOMER_ANNOTATEPEAKS { label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -14,7 +14,7 @@ process PLOT_HOMER_ANNOTATEPEAKS { input: path annos val suffix - val opts + val options output: path '*.txt', emit: txt @@ -25,6 +25,6 @@ process PLOT_HOMER_ANNOTATEPEAKS { plot_homer_annotatepeaks.r \\ -i ${annos.join(',')} \\ -s ${annos.join(',').replaceAll("${suffix}","")} \\ - $opts.args + $options.args """ } diff --git a/modules/local/process/plot_macs2_qc.nf b/modules/local/process/plot_macs2_qc.nf index a44737e50..fe17c6b7f 100644 --- a/modules/local/process/plot_macs2_qc.nf +++ b/modules/local/process/plot_macs2_qc.nf @@ -3,17 +3,17 @@ */ process PLOT_MACS2_QC { label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) input: path peaks - val opts + val options output: path '*.txt', emit: txt @@ -25,6 +25,6 @@ process PLOT_MACS2_QC { plot_macs2_qc.r \\ -i ${peaks.join(',')} \\ -s ${peaks.join(',').replaceAll("_peaks.${peak_type}","")} \\ - $opts.args + $options.args """ } diff --git a/modules/local/process/samplesheet_check.nf b/modules/local/process/samplesheet_check.nf index cfdb89572..29d43e718 100755 --- a/modules/local/process/samplesheet_check.nf +++ b/modules/local/process/samplesheet_check.nf @@ -3,17 +3,17 @@ */ process SAMPLESHEET_CHECK { tag "$samplesheet" - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else filename } conda (params.conda ? "${baseDir}/environment.yml" : null) input: path samplesheet - val opts + val options output: path '*.csv' diff --git a/modules/local/subworkflow/bam_clean.nf b/modules/local/subworkflow/bam_clean.nf index 0b79b5969..e9813fddd 100644 --- a/modules/local/subworkflow/bam_clean.nf +++ b/modules/local/subworkflow/bam_clean.nf @@ -12,14 +12,14 @@ workflow BAM_CLEAN { ch_bed // channel: [ bed ] bamtools_filter_se_config // file: BAMtools filter JSON config file for SE data bamtools_filter_pe_config // file: BAMtools filter JSON config file for PE data - bam_filter_opts // map: options for bam_filter module - bam_remove_orphans_opts // map: options for bam_remove_orphans module - samtools_opts // map: options for SAMTools modules + bam_filter_options // map: options for bam_filter module + bam_remove_orphans_options // map: options for bam_remove_orphans module + samtools_options // map: options for SAMTools modules main: - BAM_FILTER(ch_bam_bai, ch_bed, bamtools_filter_se_config, bamtools_filter_pe_config, bam_filter_opts) - BAM_REMOVE_ORPHANS(BAM_FILTER.out.bam, bam_remove_orphans_opts) - BAM_SORT_SAMTOOLS(BAM_REMOVE_ORPHANS.out.bam, samtools_opts) + BAM_FILTER(ch_bam_bai, ch_bed, bamtools_filter_se_config, bamtools_filter_pe_config, bam_filter_options) + BAM_REMOVE_ORPHANS(BAM_FILTER.out.bam, bam_remove_orphans_options) + BAM_SORT_SAMTOOLS(BAM_REMOVE_ORPHANS.out.bam, samtools_options) emit: name_bam = BAM_REMOVE_ORPHANS.out.bam // channel: [ val(meta), [ bam ] ] diff --git a/modules/local/subworkflow/input_check.nf b/modules/local/subworkflow/input_check.nf index 79b02402c..88c6cac11 100644 --- a/modules/local/subworkflow/input_check.nf +++ b/modules/local/subworkflow/input_check.nf @@ -7,12 +7,12 @@ include { SAMPLESHEET_CHECK; workflow INPUT_CHECK { take: - ch_input // file: /path/to/samplesheet.csv - seq_center // string: sequencing center for read group - samplesheet_check_opts // map: options for check_samplesheet module + ch_input // file: /path/to/samplesheet.csv + seq_center // string: sequencing center for read group + samplesheet_check_options // map: options for check_samplesheet module main: - SAMPLESHEET_CHECK (ch_input, samplesheet_check_opts) + SAMPLESHEET_CHECK (ch_input, samplesheet_check_options) .splitCsv(header:true, sep:',') .map { get_samplesheet_paths(it, seq_center) } .set { ch_reads } diff --git a/modules/nf-core/software/bwa_index.nf b/modules/nf-core/software/bwa_index.nf index cbe788bd7..5cdf4c1ba 100644 --- a/modules/nf-core/software/bwa_index.nf +++ b/modules/nf-core/software/bwa_index.nf @@ -3,10 +3,10 @@ def SOFTWARE = 'bwa' process BWA_INDEX { tag "$fasta" label 'process_high' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -17,7 +17,7 @@ process BWA_INDEX { input: path fasta - val opts + val options output: path "${fasta}.*", emit: index @@ -25,7 +25,7 @@ process BWA_INDEX { script: """ - bwa index $opts.args $fasta + bwa index $options.args $fasta echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/bwa_mem.nf b/modules/nf-core/software/bwa_mem.nf index 73012e770..a0d350b3e 100644 --- a/modules/nf-core/software/bwa_mem.nf +++ b/modules/nf-core/software/bwa_mem.nf @@ -3,10 +3,10 @@ def SOFTWARE = 'bwa' process BWA_MEM { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -19,24 +19,24 @@ process BWA_MEM { tuple val(meta), path(reads) path index path fasta - val opts + val options output: tuple val(meta), path("*.bam"), emit: bam path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" rg = meta.read_group ? "-R ${meta.read_group}" : "" """ bwa mem \\ - $opts.args \\ + $options.args \\ $rg \\ -t $task.cpus \\ $fasta \\ $reads \\ - | samtools view $opts.args2 -@ $task.cpus -bS -o ${prefix}.bam - - + | samtools view $options.args2 -@ $task.cpus -bS -o ${prefix}.bam - + echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/deeptools_computematrix.nf b/modules/nf-core/software/deeptools_computematrix.nf index f1d303a56..e9b2ec06b 100644 --- a/modules/nf-core/software/deeptools_computematrix.nf +++ b/modules/nf-core/software/deeptools_computematrix.nf @@ -3,10 +3,10 @@ def SOFTWARE = 'deeptools' process DEEPTOOLS_COMPUTEMATRIX { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -18,7 +18,7 @@ process DEEPTOOLS_COMPUTEMATRIX { input: tuple val(meta), path(bigwig) path bed - val opts + val options output: tuple val(meta), path("*.mat.gz"), emit: matrix @@ -26,10 +26,10 @@ process DEEPTOOLS_COMPUTEMATRIX { path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" """ computeMatrix \\ - $opts.args \\ + $options.args \\ --regionsFileName $bed \\ --scoreFileName $bigwig \\ --outFileName ${prefix}.computeMatrix.mat.gz \\ diff --git a/modules/nf-core/software/deeptools_plotfingerprint.nf b/modules/nf-core/software/deeptools_plotfingerprint.nf index 35f706535..a7ecd0cb8 100644 --- a/modules/nf-core/software/deeptools_plotfingerprint.nf +++ b/modules/nf-core/software/deeptools_plotfingerprint.nf @@ -3,10 +3,10 @@ def SOFTWARE = 'deeptools' process DEEPTOOLS_PLOTFINGERPRINT { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -17,7 +17,7 @@ process DEEPTOOLS_PLOTFINGERPRINT { input: tuple val(meta), path(bams), path(bais) - val opts + val options output: tuple val(meta), path("*.pdf"), emit: pdf @@ -26,11 +26,11 @@ process DEEPTOOLS_PLOTFINGERPRINT { path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" extend = (meta.single_end && params.fragment_size > 0) ? "--extendReads ${params.fragment_size}" : '' """ plotFingerprint \\ - $opts.args \\ + $options.args \\ $extend \\ --bamfiles ${bams.join(' ')} \\ --plotFile ${prefix}.plotFingerprint.pdf \\ diff --git a/modules/nf-core/software/deeptools_plotheatmap.nf b/modules/nf-core/software/deeptools_plotheatmap.nf index fa9787136..e12fa6c7e 100644 --- a/modules/nf-core/software/deeptools_plotheatmap.nf +++ b/modules/nf-core/software/deeptools_plotheatmap.nf @@ -3,10 +3,10 @@ def SOFTWARE = 'deeptools' process DEEPTOOLS_PLOTHEATMAP { tag "$meta.id" label 'process_low' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -17,7 +17,7 @@ process DEEPTOOLS_PLOTHEATMAP { input: tuple val(meta), path(matrix) - val opts + val options output: tuple val(meta), path("*.pdf"), emit: pdf @@ -25,10 +25,10 @@ process DEEPTOOLS_PLOTHEATMAP { path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" """ plotHeatmap \\ - $opts.args \\ + $options.args \\ --matrixFile $matrix \\ --outFileName ${prefix}.plotHeatmap.pdf \\ --outFileNameMatrix ${prefix}.plotHeatmap.mat.tab diff --git a/modules/nf-core/software/deeptools_plotprofile.nf b/modules/nf-core/software/deeptools_plotprofile.nf index b90c171a9..a34de4cda 100644 --- a/modules/nf-core/software/deeptools_plotprofile.nf +++ b/modules/nf-core/software/deeptools_plotprofile.nf @@ -3,10 +3,10 @@ def SOFTWARE = 'deeptools' process DEEPTOOLS_PLOTPROFILE { tag "$meta.id" label 'process_low' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -17,7 +17,7 @@ process DEEPTOOLS_PLOTPROFILE { input: tuple val(meta), path(matrix) - val opts + val options output: tuple val(meta), path("*.pdf"), emit: pdf @@ -25,10 +25,10 @@ process DEEPTOOLS_PLOTPROFILE { path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" """ plotProfile \\ - $opts.args \\ + $options.args \\ --matrixFile $matrix \\ --outFileName ${prefix}.plotProfile.pdf \\ --outFileNameData ${prefix}.plotProfile.tab diff --git a/modules/nf-core/software/fastqc.nf b/modules/nf-core/software/fastqc.nf index 4a69d8218..f526e8d98 100755 --- a/modules/nf-core/software/fastqc.nf +++ b/modules/nf-core/software/fastqc.nf @@ -3,10 +3,10 @@ def SOFTWARE = 'fastqc' process FASTQC { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -17,7 +17,7 @@ process FASTQC { input: tuple val(meta), path(reads) - val opts + val options output: tuple val(meta), path("*.html"), emit: html @@ -26,18 +26,18 @@ process FASTQC { script: // Add soft-links to original FastQs for consistent naming in pipeline - prefix = opts.suffix ? "${meta.id}.${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}.${options.suffix}" : "${meta.id}" if (meta.single_end) { """ [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz - fastqc $opts.args --threads $task.cpus ${prefix}.fastq.gz + fastqc $options.args --threads $task.cpus ${prefix}.fastq.gz fastqc --version | sed -e "s/FastQC v//g" > ${SOFTWARE}.version.txt """ } else { """ [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz - fastqc $opts.args --threads $task.cpus ${prefix}_1.fastq.gz ${prefix}_2.fastq.gz + fastqc $options.args --threads $task.cpus ${prefix}_1.fastq.gz ${prefix}_2.fastq.gz fastqc --version | sed -e "s/FastQC v//g" > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf index 4d53de8da..cf09a4847 100644 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ b/modules/nf-core/software/homer_annotatepeaks.nf @@ -4,10 +4,10 @@ def VERSION = '4.11' process HOMER_ANNOTATEPEAKS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -20,19 +20,19 @@ process HOMER_ANNOTATEPEAKS { tuple val(meta), path(peak) path fasta path gtf - val opts + val options output: tuple val(meta), path("*annotatePeaks.txt"), emit: txt path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" """ annotatePeaks.pl \\ $peak \\ $fasta \\ - $opts.args \\ + $options.args \\ -gtf $gtf \\ -cpu $task.cpus \\ > ${prefix}.annotatePeaks.txt diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf index 8821df938..f4bfac096 100644 --- a/modules/nf-core/software/macs2_callpeak.nf +++ b/modules/nf-core/software/macs2_callpeak.nf @@ -3,10 +3,10 @@ def SOFTWARE = 'macs2' process MACS2_CALLPEAK { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -18,7 +18,7 @@ process MACS2_CALLPEAK { input: tuple val(meta), path(ipbam), path(controlbam) val macs2_gsize - val opts + val options output: tuple val(meta), path("*.{narrowPeak,broadPeak}"), emit: peak @@ -29,13 +29,13 @@ process MACS2_CALLPEAK { path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" format = meta.single_end ? 'BAM' : 'BAMPE' control = controlbam ? "--control $controlbam" : '' """ macs2 \\ callpeak \\ - $opts.args \\ + $options.args \\ --gsize $macs2_gsize \\ --format $format \\ --name $prefix \\ diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf index 22b2d9e74..a6df15650 100644 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ b/modules/nf-core/software/phantompeakqualtools.nf @@ -4,10 +4,10 @@ def VERSION = '1.2.2' process PHANTOMPEAKQUALTOOLS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -18,7 +18,7 @@ process PHANTOMPEAKQUALTOOLS { input: tuple val(meta), path(bam) - val opts + val options output: tuple val(meta), path("*.out"), emit: spp @@ -26,7 +26,7 @@ process PHANTOMPEAKQUALTOOLS { path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" """ RUN_SPP=`which run_spp.R` Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus diff --git a/modules/nf-core/software/picard_collectmultiplemetrics.nf b/modules/nf-core/software/picard_collectmultiplemetrics.nf index 3f5b1c5c3..1f9dd9bab 100644 --- a/modules/nf-core/software/picard_collectmultiplemetrics.nf +++ b/modules/nf-core/software/picard_collectmultiplemetrics.nf @@ -3,10 +3,10 @@ def SOFTWARE = 'picard' process PICARD_COLLECTMULTIPLEMETRICS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -18,7 +18,7 @@ process PICARD_COLLECTMULTIPLEMETRICS { input: tuple val(meta), path(bam) path fasta - val opts + val options output: tuple val(meta), path("*_metrics"), emit: metrics @@ -26,7 +26,7 @@ process PICARD_COLLECTMULTIPLEMETRICS { path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" def avail_mem = 3 if (!task.memory) { log.info '[Picard CollectMultipleMetrics] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' @@ -37,7 +37,7 @@ process PICARD_COLLECTMULTIPLEMETRICS { picard \\ -Xmx${avail_mem}g \\ CollectMultipleMetrics \\ - $opts.args \\ + $options.args \\ INPUT=$bam \\ OUTPUT=${prefix}.CollectMultipleMetrics \\ REFERENCE_SEQUENCE=$fasta diff --git a/modules/nf-core/software/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf index 31c56bedd..338e269b5 100644 --- a/modules/nf-core/software/picard_markduplicates.nf +++ b/modules/nf-core/software/picard_markduplicates.nf @@ -3,10 +3,10 @@ def SOFTWARE = 'picard' process PICARD_MARKDUPLICATES { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -17,7 +17,7 @@ process PICARD_MARKDUPLICATES { input: tuple val(meta), path(bam) - val opts + val options output: tuple val(meta), path("*.bam"), emit: bam @@ -25,7 +25,7 @@ process PICARD_MARKDUPLICATES { path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" def avail_mem = 3 if (!task.memory) { log.info '[Picard MarkDuplicates] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' @@ -36,7 +36,7 @@ process PICARD_MARKDUPLICATES { picard \\ -Xmx${avail_mem}g \\ MarkDuplicates \\ - $opts.args \\ + $options.args \\ INPUT=$bam \\ OUTPUT=${prefix}.bam \\ METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt diff --git a/modules/nf-core/software/picard_mergesamfiles.nf b/modules/nf-core/software/picard_mergesamfiles.nf index 76ea07ea8..2a4630a7b 100644 --- a/modules/nf-core/software/picard_mergesamfiles.nf +++ b/modules/nf-core/software/picard_mergesamfiles.nf @@ -3,10 +3,10 @@ def SOFTWARE = 'picard' process PICARD_MERGESAMFILES { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -17,14 +17,14 @@ process PICARD_MERGESAMFILES { input: tuple val(meta), path(bams) - val opts + val options output: tuple val(meta), path("*.bam"), emit: bam path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" bam_files = bams.sort() def avail_mem = 3 if (!task.memory) { @@ -37,7 +37,7 @@ process PICARD_MERGESAMFILES { picard \\ -Xmx${avail_mem}g \\ MergeSamFiles \\ - $opts.args \\ + $options.args \\ ${'INPUT='+bam_files.join(' INPUT=')} \\ OUTPUT=${prefix}.bam echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${SOFTWARE}.version.txt diff --git a/modules/nf-core/software/preseq_lcextrap.nf b/modules/nf-core/software/preseq_lcextrap.nf index b537077e9..4c9d24708 100644 --- a/modules/nf-core/software/preseq_lcextrap.nf +++ b/modules/nf-core/software/preseq_lcextrap.nf @@ -4,10 +4,10 @@ process PRESEQ_LCEXTRAP { tag "$meta.id" label 'process_medium' label 'error_ignore' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -18,7 +18,7 @@ process PRESEQ_LCEXTRAP { input: tuple val(meta), path(bam) - val opts + val options output: tuple val(meta), path("*.ccurve.txt"), emit: ccurve @@ -26,17 +26,17 @@ process PRESEQ_LCEXTRAP { path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" pe = meta.single_end ? '' : '-pe' """ preseq \\ lc_extrap \\ - $opts.args \\ + $options.args \\ $pe \\ -output ${prefix}.ccurve.txt \\ $bam cp .command.err ${prefix}.command.log - + echo \$(preseq 2>&1) | sed 's/^.*Version: //; s/Usage:.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/samtools_flagstat.nf b/modules/nf-core/software/samtools_flagstat.nf index 537ab8cf6..8a17bba19 100644 --- a/modules/nf-core/software/samtools_flagstat.nf +++ b/modules/nf-core/software/samtools_flagstat.nf @@ -2,10 +2,10 @@ def SOFTWARE = 'samtools' process SAMTOOLS_FLAGSTAT { tag "$meta.id" - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -16,7 +16,7 @@ process SAMTOOLS_FLAGSTAT { input: tuple val(meta), path(bam), path(bai) - val opts + val options output: tuple val(meta), path("*.flagstat"), emit: flagstat diff --git a/modules/nf-core/software/samtools_idxstats.nf b/modules/nf-core/software/samtools_idxstats.nf index cdedf6bdf..0dab14709 100644 --- a/modules/nf-core/software/samtools_idxstats.nf +++ b/modules/nf-core/software/samtools_idxstats.nf @@ -2,10 +2,10 @@ def SOFTWARE = 'samtools' process SAMTOOLS_IDXSTATS { tag "$meta.id" - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -16,7 +16,7 @@ process SAMTOOLS_IDXSTATS { input: tuple val(meta), path(bam), path(bai) - val opts + val options output: tuple val(meta), path("*.idxstats"), emit: idxstats diff --git a/modules/nf-core/software/samtools_index.nf b/modules/nf-core/software/samtools_index.nf index 7c17e1fe0..372a3d994 100644 --- a/modules/nf-core/software/samtools_index.nf +++ b/modules/nf-core/software/samtools_index.nf @@ -2,10 +2,10 @@ def SOFTWARE = 'samtools' process SAMTOOLS_INDEX { tag "$meta.id" - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -16,7 +16,7 @@ process SAMTOOLS_INDEX { input: tuple val(meta), path(bam) - val opts + val options output: tuple val(meta), path("*.bai"), emit: bai diff --git a/modules/nf-core/software/samtools_sort.nf b/modules/nf-core/software/samtools_sort.nf index 61289303d..0249ee3cf 100644 --- a/modules/nf-core/software/samtools_sort.nf +++ b/modules/nf-core/software/samtools_sort.nf @@ -3,10 +3,10 @@ def SOFTWARE = 'samtools' process SAMTOOLS_SORT { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -17,16 +17,16 @@ process SAMTOOLS_SORT { input: tuple val(meta), path(bam) - val opts + val options output: tuple val(meta), path("*.bam"), emit: bam path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" """ - samtools sort $opts.args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam + samtools sort $options.args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/samtools_stats.nf b/modules/nf-core/software/samtools_stats.nf index 55f125797..e1ddb90c8 100644 --- a/modules/nf-core/software/samtools_stats.nf +++ b/modules/nf-core/software/samtools_stats.nf @@ -2,10 +2,10 @@ def SOFTWARE = 'samtools' process SAMTOOLS_STATS { tag "$meta.id" - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -16,7 +16,7 @@ process SAMTOOLS_STATS { input: tuple val(meta), path(bam), path(bai) - val opts + val options output: tuple val(meta), path("*.stats"), emit: stats diff --git a/modules/nf-core/software/trimgalore.nf b/modules/nf-core/software/trimgalore.nf index 59cc12dfd..b740fbc43 100644 --- a/modules/nf-core/software/trimgalore.nf +++ b/modules/nf-core/software/trimgalore.nf @@ -3,10 +3,10 @@ def SOFTWARE = 'trimgalore' process TRIMGALORE { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -17,7 +17,7 @@ process TRIMGALORE { input: tuple val(meta), path(reads) - val opts + val options output: tuple val(meta), path("*.fq.gz"), emit: reads @@ -45,12 +45,12 @@ process TRIMGALORE { tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' // Added soft-links to original fastqs for consistent naming in MultiQC - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" if (meta.single_end) { """ [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz trim_galore \\ - $opts.args \\ + $options.args \\ --cores $cores \\ --gzip \\ $c_r1 \\ @@ -63,7 +63,7 @@ process TRIMGALORE { [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz trim_galore \\ - $opts.args \\ + $options.args \\ --cores $cores \\ --paired \\ --gzip \\ diff --git a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf index 544550f35..5059e4313 100644 --- a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf +++ b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf @@ -4,10 +4,10 @@ def VERSION = '377' process UCSC_BEDRAPHTOBIGWIG { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${opts.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, saveAs: { filename -> - if (opts.publish_results == "none") null + if (options.publish_results == "none") null else if (filename.endsWith('.version.txt')) null else filename } @@ -19,14 +19,14 @@ process UCSC_BEDRAPHTOBIGWIG { input: tuple val(meta), path(bedgraph) path sizes - val opts + val options output: tuple val(meta), path("*.bigWig"), emit: bigwig path "*.version.txt", emit: version script: - prefix = opts.suffix ? "${meta.id}${opts.suffix}" : "${meta.id}" + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" """ bedGraphToBigWig $bedgraph $sizes ${prefix}.bigWig echo $VERSION > ${SOFTWARE}.version.txt diff --git a/modules/nf-core/subworkflow/bam_sort_samtools.nf b/modules/nf-core/subworkflow/bam_sort_samtools.nf index 7efb10245..c58c23ac7 100644 --- a/modules/nf-core/subworkflow/bam_sort_samtools.nf +++ b/modules/nf-core/subworkflow/bam_sort_samtools.nf @@ -8,13 +8,13 @@ include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' workflow BAM_SORT_SAMTOOLS { take: - ch_bam // channel: [ val(meta), [ bam ] ] - samtools_opts // map: options for SAMTools modules + ch_bam // channel: [ val(meta), [ bam ] ] + samtools_options // map: options for SAMTools modules main: - SAMTOOLS_SORT(ch_bam, samtools_opts) - SAMTOOLS_INDEX(SAMTOOLS_SORT.out.bam, samtools_opts) - BAM_STATS_SAMTOOLS(SAMTOOLS_SORT.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_opts) + SAMTOOLS_SORT(ch_bam, samtools_options) + SAMTOOLS_INDEX(SAMTOOLS_SORT.out.bam, samtools_options) + BAM_STATS_SAMTOOLS(SAMTOOLS_SORT.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_options) emit: bam = SAMTOOLS_SORT.out.bam // channel: [ val(meta), [ bam ] ] diff --git a/modules/nf-core/subworkflow/bam_stats_samtools.nf b/modules/nf-core/subworkflow/bam_stats_samtools.nf index 5f2b6d5c7..9178106b1 100644 --- a/modules/nf-core/subworkflow/bam_stats_samtools.nf +++ b/modules/nf-core/subworkflow/bam_stats_samtools.nf @@ -8,13 +8,13 @@ include { SAMTOOLS_FLAGSTAT } from '../software/samtools_flagstat' workflow BAM_STATS_SAMTOOLS { take: - ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] - samtools_opts // map: options for SAMTools modules + ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] + samtools_options // map: options for SAMTools modules main: - SAMTOOLS_STATS(ch_bam_bai, samtools_opts) - SAMTOOLS_FLAGSTAT(ch_bam_bai, samtools_opts) - SAMTOOLS_IDXSTATS(ch_bam_bai, samtools_opts) + SAMTOOLS_STATS(ch_bam_bai, samtools_options) + SAMTOOLS_FLAGSTAT(ch_bam_bai, samtools_options) + SAMTOOLS_IDXSTATS(ch_bam_bai, samtools_options) emit: stats = SAMTOOLS_STATS.out.stats // channel: [ val(meta), [ stats ] ] diff --git a/modules/nf-core/subworkflow/fastqc_trimgalore.nf b/modules/nf-core/subworkflow/fastqc_trimgalore.nf index 701075771..8cb75d659 100644 --- a/modules/nf-core/subworkflow/fastqc_trimgalore.nf +++ b/modules/nf-core/subworkflow/fastqc_trimgalore.nf @@ -7,18 +7,18 @@ include { TRIMGALORE } from '../software/trimgalore' workflow FASTQC_TRIMGALORE { take: - ch_reads // channel: [ val(meta), [ reads ] ] - skip_fastqc // boolean: true/false - skip_trimming // boolean: true/false - fastqc_opts // map: options for FastQC module - trimgalore_opts // map: options for TrimGalore! module + ch_reads // channel: [ val(meta), [ reads ] ] + skip_fastqc // boolean: true/false + skip_trimming // boolean: true/false + fastqc_options // map: options for FastQC module + trimgalore_options // map: options for TrimGalore! module main: fastqc_html = Channel.empty() fastqc_zip = Channel.empty() fastqc_version = Channel.empty() if (!skip_fastqc) { - FASTQC(ch_reads, fastqc_opts).html.set { fastqc_html } + FASTQC(ch_reads, fastqc_options).html.set { fastqc_html } fastqc_zip = FASTQC.out.zip fastqc_version = FASTQC.out.version } @@ -29,7 +29,7 @@ workflow FASTQC_TRIMGALORE { trim_log = Channel.empty() trimgalore_version = Channel.empty() if (!skip_trimming) { - TRIMGALORE(ch_reads, trimgalore_opts).reads.set { ch_trim_reads } + TRIMGALORE(ch_reads, trimgalore_options).reads.set { ch_trim_reads } trim_html = TRIMGALORE.out.html trim_zip = TRIMGALORE.out.zip trim_log = TRIMGALORE.out.log diff --git a/modules/nf-core/subworkflow/map_bwa_mem.nf b/modules/nf-core/subworkflow/map_bwa_mem.nf index 7f0338299..008c2dc3f 100644 --- a/modules/nf-core/subworkflow/map_bwa_mem.nf +++ b/modules/nf-core/subworkflow/map_bwa_mem.nf @@ -7,15 +7,15 @@ include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' workflow MAP_BWA_MEM { take: - ch_reads // channel: [ val(meta), [ reads ] ] - ch_index // path: /path/to/index - ch_fasta // path: /path/to/genome.fasta - bwa_mem_opts // map: options for BWA MEM module - samtools_opts // map: options for SAMTools modules + ch_reads // channel: [ val(meta), [ reads ] ] + ch_index // path: /path/to/index + ch_fasta // path: /path/to/genome.fasta + bwa_mem_options // map: options for BWA MEM module + samtools_options // map: options for SAMTools modules main: - BWA_MEM(ch_reads, ch_index, ch_fasta, bwa_mem_opts) - BAM_SORT_SAMTOOLS(BWA_MEM.out.bam, samtools_opts) + BWA_MEM(ch_reads, ch_index, ch_fasta, bwa_mem_options) + BAM_SORT_SAMTOOLS(BWA_MEM.out.bam, samtools_options) emit: bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] diff --git a/modules/nf-core/subworkflow/mark_duplicates_picard.nf b/modules/nf-core/subworkflow/mark_duplicates_picard.nf index 335a9d9a9..9bec786f3 100644 --- a/modules/nf-core/subworkflow/mark_duplicates_picard.nf +++ b/modules/nf-core/subworkflow/mark_duplicates_picard.nf @@ -8,14 +8,14 @@ include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' workflow MARK_DUPLICATES_PICARD { take: - ch_bam // channel: [ val(meta), [ bam ] ] - markduplicates_opts // map: options for picard MarkDuplicates module - samtools_opts // map: options for SAMTools modules + ch_bam // channel: [ val(meta), [ bam ] ] + markduplicates_options // map: options for picard MarkDuplicates module + samtools_options // map: options for SAMTools modules main: - PICARD_MARKDUPLICATES(ch_bam, markduplicates_opts) - SAMTOOLS_INDEX(PICARD_MARKDUPLICATES.out.bam, samtools_opts) - BAM_STATS_SAMTOOLS(PICARD_MARKDUPLICATES.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_opts) + PICARD_MARKDUPLICATES(ch_bam, markduplicates_options) + SAMTOOLS_INDEX(PICARD_MARKDUPLICATES.out.bam, samtools_options) + BAM_STATS_SAMTOOLS(PICARD_MARKDUPLICATES.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_options) emit: bam = PICARD_MARKDUPLICATES.out.bam // channel: [ val(meta), [ bam ] ] From f2b12df44e3f23a62fb14fea59fe5fe84c1a092f Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 29 Jul 2020 13:29:49 +0100 Subject: [PATCH 083/538] Add options to publish_by_id --- conf/modules.config | 39 +++++++++++++++++++++++++++++++++++++++ 1 file changed, 39 insertions(+) diff --git a/conf/modules.config b/conf/modules.config index 25334b035..baab712aa 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -10,42 +10,49 @@ params { suffix = "" publish_dir = "pipeline_info" publish_results = "all" + publish_by_id = false } 'fastqc' { args = "--quiet" suffix = "" publish_dir = "fastqc" publish_results = "all" + publish_by_id = false } 'trimgalore' { args = "--fastqc" suffix = "" publish_dir = "trim_galore" publish_results = "all" + publish_by_id = false } 'bwa_index' { args = "-a bwtsw" suffix = "" publish_dir = "genome/bwa_index" publish_results = "all" + publish_by_id = false } 'gtf2bed' { args = "" suffix = "" publish_dir = "genome" publish_results = "all" + publish_by_id = false } 'make_genome_filter' { args = "" suffix = "" publish_dir = "genome" publish_results = "all" + publish_by_id = false } 'get_chrom_sizes' { args = "" suffix = "" publish_dir = "genome" publish_results = "all" + publish_by_id = false } 'bwa_mem' { args = "-M" @@ -53,150 +60,182 @@ params { suffix = ".Lb" publish_dir = "bwa/library" publish_results = "all" + publish_by_id = false } 'samtools_sort_lib' { args = "" suffix = ".Lb.sorted" publish_dir = "bwa/library" publish_results = "all" + publish_by_id = false } 'picard_mergesamfiles' { args = "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" suffix = ".mLb.sorted" publish_dir = "bwa/mergedLibrary" publish_results = "all" + publish_by_id = false } 'picard_markduplicates' { args = "ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" suffix = ".mLb.mkD.sorted" publish_dir = "bwa/mergedLibrary" publish_results = "all" + publish_by_id = false } 'samtools_sort_merged_lib' { args = "" suffix = ".mLb.mkD.sorted" publish_dir = "bwa/mergedLibrary" publish_results = "all" + publish_by_id = false } 'bam_filter' { args = "" suffix = ".mLb.flT.sorted" publish_dir = "bwa/mergedLibrary" publish_results = "all" + publish_by_id = false } 'bam_remove_orphans' { args = "--only_fr_pairs" suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary" publish_results = "all" + publish_by_id = false } 'samtools_sort_filter' { args = "" suffix = ".mLb.clN.sorted" publish_dir = "bwa/mergedLibrary" publish_results = "all" + publish_by_id = false } 'picard_collectmultiplemetrics' { args = "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" suffix = ".mLb.clN.sorted" publish_dir = "bwa/mergedLibrary/picard_metrics" publish_results = "all" + publish_by_id = false } 'preseq_lcextrap' { args = "-verbose -bam -seed 1" suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/preseq" publish_results = "all" + publish_by_id = false } 'phantompeakqualtools' { args = "" suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/phantompeakqualtools" publish_results = "all" + publish_by_id = false } 'bedtools_genomecov' { args = "" suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/bigwig" publish_results = "all" + publish_by_id = false } 'ucsc_bedgraphtobigwig' { args = "" suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/bigwig" publish_results = "all" + publish_by_id = false } 'deeptools_computematrix' { args = "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels" suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/deeptools" publish_results = "all" + publish_by_id = false } 'deeptools_plotprofile' { args = "" suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/deeptools" publish_results = "all" + publish_by_id = false } 'deeptools_plotheatmap' { args = "" suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/deeptools" publish_results = "all" + publish_by_id = false } 'deeptools_plotfingerprint' { args = "--skipZeros" suffix = ".mLb.clN" publish_dir = "bwa/mergedLibrary/deeptools" publish_results = "all" + publish_by_id = false } 'macs2_callpeak' { args = "--keep-dup all" suffix = "" publish_dir = "bwa/mergedLibrary/macs2" publish_results = "all" + publish_by_id = false } 'plot_macs2_qc' { args = "-o ./ -p macs2_peak" suffix = "" publish_dir = "bwa/mergedLibrary/macs2" publish_results = "all" + publish_by_id = false } 'homer_annotatepeaks_macs2' { args = "-gid" suffix = "_peaks" publish_dir = "bwa/mergedLibrary/macs2" publish_results = "all" + publish_by_id = false } 'plot_homer_annotatepeaks' { args = "-o ./ -p macs2_annotatePeaks" suffix = "" publish_dir = "bwa/mergedLibrary/macs2" publish_results = "all" + publish_by_id = false } 'macs2_consensus' { args = "" suffix = "" publish_dir = "bwa/mergedLibrary/macs2" publish_results = "all" + publish_by_id = false + } + 'homer_annotatepeaks_consensus' { + args = "-gid" + suffix = "" + publish_dir = "bwa/mergedLibrary/macs2" + publish_results = "all" + publish_by_id = true } 'get_software_versions' { args = "" suffix = "" publish_dir = "pipeline_info" publish_results = "all" + publish_by_id = false } 'output_documentation' { args = "" suffix = "" publish_dir = "pipeline_info" publish_results = "all" + publish_by_id = false } 'multiqc' { args = "" suffix = "" publish_dir = "multiqc" publish_results = "all" + publish_by_id = false } } } From dc2bbdd0171801b8d87ec58b9bdc9e74bba3ba98 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 29 Jul 2020 14:00:47 +0100 Subject: [PATCH 084/538] Replace explicit declaration with initialised map --- conf/modules.config | 489 +++++++++++++++++++++++--------------------- 1 file changed, 254 insertions(+), 235 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index baab712aa..7b7768754 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -3,239 +3,258 @@ * Nextflow config file for module specific-options * ------------------------------------------------- */ -params { - modules { - 'samplesheet_check' { - args = "" - suffix = "" - publish_dir = "pipeline_info" - publish_results = "all" - publish_by_id = false - } - 'fastqc' { - args = "--quiet" - suffix = "" - publish_dir = "fastqc" - publish_results = "all" - publish_by_id = false - } - 'trimgalore' { - args = "--fastqc" - suffix = "" - publish_dir = "trim_galore" - publish_results = "all" - publish_by_id = false - } - 'bwa_index' { - args = "-a bwtsw" - suffix = "" - publish_dir = "genome/bwa_index" - publish_results = "all" - publish_by_id = false - } - 'gtf2bed' { - args = "" - suffix = "" - publish_dir = "genome" - publish_results = "all" - publish_by_id = false - } - 'make_genome_filter' { - args = "" - suffix = "" - publish_dir = "genome" - publish_results = "all" - publish_by_id = false - } - 'get_chrom_sizes' { - args = "" - suffix = "" - publish_dir = "genome" - publish_results = "all" - publish_by_id = false - } - 'bwa_mem' { - args = "-M" - args2 = "-h -F 0x0100 -O BAM" - suffix = ".Lb" - publish_dir = "bwa/library" - publish_results = "all" - publish_by_id = false - } - 'samtools_sort_lib' { - args = "" - suffix = ".Lb.sorted" - publish_dir = "bwa/library" - publish_results = "all" - publish_by_id = false - } - 'picard_mergesamfiles' { - args = "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" - suffix = ".mLb.sorted" - publish_dir = "bwa/mergedLibrary" - publish_results = "all" - publish_by_id = false - } - 'picard_markduplicates' { - args = "ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" - suffix = ".mLb.mkD.sorted" - publish_dir = "bwa/mergedLibrary" - publish_results = "all" - publish_by_id = false - } - 'samtools_sort_merged_lib' { - args = "" - suffix = ".mLb.mkD.sorted" - publish_dir = "bwa/mergedLibrary" - publish_results = "all" - publish_by_id = false - } - 'bam_filter' { - args = "" - suffix = ".mLb.flT.sorted" - publish_dir = "bwa/mergedLibrary" - publish_results = "all" - publish_by_id = false - } - 'bam_remove_orphans' { - args = "--only_fr_pairs" - suffix = ".mLb.clN" - publish_dir = "bwa/mergedLibrary" - publish_results = "all" - publish_by_id = false - } - 'samtools_sort_filter' { - args = "" - suffix = ".mLb.clN.sorted" - publish_dir = "bwa/mergedLibrary" - publish_results = "all" - publish_by_id = false - } - 'picard_collectmultiplemetrics' { - args = "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" - suffix = ".mLb.clN.sorted" - publish_dir = "bwa/mergedLibrary/picard_metrics" - publish_results = "all" - publish_by_id = false - } - 'preseq_lcextrap' { - args = "-verbose -bam -seed 1" - suffix = ".mLb.clN" - publish_dir = "bwa/mergedLibrary/preseq" - publish_results = "all" - publish_by_id = false - } - 'phantompeakqualtools' { - args = "" - suffix = ".mLb.clN" - publish_dir = "bwa/mergedLibrary/phantompeakqualtools" - publish_results = "all" - publish_by_id = false - } - 'bedtools_genomecov' { - args = "" - suffix = ".mLb.clN" - publish_dir = "bwa/mergedLibrary/bigwig" - publish_results = "all" - publish_by_id = false - } - 'ucsc_bedgraphtobigwig' { - args = "" - suffix = ".mLb.clN" - publish_dir = "bwa/mergedLibrary/bigwig" - publish_results = "all" - publish_by_id = false - } - 'deeptools_computematrix' { - args = "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels" - suffix = ".mLb.clN" - publish_dir = "bwa/mergedLibrary/deeptools" - publish_results = "all" - publish_by_id = false - } - 'deeptools_plotprofile' { - args = "" - suffix = ".mLb.clN" - publish_dir = "bwa/mergedLibrary/deeptools" - publish_results = "all" - publish_by_id = false - } - 'deeptools_plotheatmap' { - args = "" - suffix = ".mLb.clN" - publish_dir = "bwa/mergedLibrary/deeptools" - publish_results = "all" - publish_by_id = false - } - 'deeptools_plotfingerprint' { - args = "--skipZeros" - suffix = ".mLb.clN" - publish_dir = "bwa/mergedLibrary/deeptools" - publish_results = "all" - publish_by_id = false - } - 'macs2_callpeak' { - args = "--keep-dup all" - suffix = "" - publish_dir = "bwa/mergedLibrary/macs2" - publish_results = "all" - publish_by_id = false - } - 'plot_macs2_qc' { - args = "-o ./ -p macs2_peak" - suffix = "" - publish_dir = "bwa/mergedLibrary/macs2" - publish_results = "all" - publish_by_id = false - } - 'homer_annotatepeaks_macs2' { - args = "-gid" - suffix = "_peaks" - publish_dir = "bwa/mergedLibrary/macs2" - publish_results = "all" - publish_by_id = false - } - 'plot_homer_annotatepeaks' { - args = "-o ./ -p macs2_annotatePeaks" - suffix = "" - publish_dir = "bwa/mergedLibrary/macs2" - publish_results = "all" - publish_by_id = false - } - 'macs2_consensus' { - args = "" - suffix = "" - publish_dir = "bwa/mergedLibrary/macs2" - publish_results = "all" - publish_by_id = false - } - 'homer_annotatepeaks_consensus' { - args = "-gid" - suffix = "" - publish_dir = "bwa/mergedLibrary/macs2" - publish_results = "all" - publish_by_id = true - } - 'get_software_versions' { - args = "" - suffix = "" - publish_dir = "pipeline_info" - publish_results = "all" - publish_by_id = false - } - 'output_documentation' { - args = "" - suffix = "" - publish_dir = "pipeline_info" - publish_results = "all" - publish_by_id = false - } - 'multiqc' { - args = "" - suffix = "" - publish_dir = "multiqc" - publish_results = "all" - publish_by_id = false - } - } + +def module_options_init(publish_dir="", args="", suffix="", publish_results="all", publish_by_id=false, args2="") { + def Map options = [:] + options.publish_dir = publish_dir + options.args = args + options.suffix = suffix + options.publish_results = publish_results + options.publish_by_id = publish_by_id + options.args2 = args2 + return options } + +def Map modules = [:] +modules['samplesheet_check'] = module_options_init(publish_dir="pipeline_info") +modules['fastqc'] = module_options_init(publish_dir="fastqc", args="--quiet") +modules['trimgalore'] = module_options_init(publish_dir="trimgalore", args="--fastqc") + +params.modules = modules +println(params.modules) +// params { +// modules { +// // 'samplesheet_check' { +// // args = "" +// // suffix = "" +// // publish_dir = "pipeline_info" +// // publish_results = "all" +// // publish_by_id = false +// // } +// 'fastqc' { +// args = "--quiet" +// suffix = "" +// publish_dir = "fastqc" +// publish_results = "all" +// publish_by_id = false +// } +// 'trimgalore' { +// args = "--fastqc" +// suffix = "" +// publish_dir = "trim_galore" +// publish_results = "all" +// publish_by_id = false +// } +// 'bwa_index' { +// args = "-a bwtsw" +// suffix = "" +// publish_dir = "genome/bwa_index" +// publish_results = "all" +// publish_by_id = false +// } +// 'gtf2bed' { +// args = "" +// suffix = "" +// publish_dir = "genome" +// publish_results = "all" +// publish_by_id = false +// } +// 'make_genome_filter' { +// args = "" +// suffix = "" +// publish_dir = "genome" +// publish_results = "all" +// publish_by_id = false +// } +// 'get_chrom_sizes' { +// args = "" +// suffix = "" +// publish_dir = "genome" +// publish_results = "all" +// publish_by_id = false +// } +// 'bwa_mem' { +// args = "-M" +// args2 = "-h -F 0x0100 -O BAM" +// suffix = ".Lb" +// publish_dir = "bwa/library" +// publish_results = "all" +// publish_by_id = false +// } +// 'samtools_sort_lib' { +// args = "" +// suffix = ".Lb.sorted" +// publish_dir = "bwa/library" +// publish_results = "all" +// publish_by_id = false +// } +// 'picard_mergesamfiles' { +// args = "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" +// suffix = ".mLb.sorted" +// publish_dir = "bwa/mergedLibrary" +// publish_results = "all" +// publish_by_id = false +// } +// 'picard_markduplicates' { +// args = "ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" +// suffix = ".mLb.mkD.sorted" +// publish_dir = "bwa/mergedLibrary" +// publish_results = "all" +// publish_by_id = false +// } +// 'samtools_sort_merged_lib' { +// args = "" +// suffix = ".mLb.mkD.sorted" +// publish_dir = "bwa/mergedLibrary" +// publish_results = "all" +// publish_by_id = false +// } +// 'bam_filter' { +// args = "" +// suffix = ".mLb.flT.sorted" +// publish_dir = "bwa/mergedLibrary" +// publish_results = "all" +// publish_by_id = false +// } +// 'bam_remove_orphans' { +// args = "--only_fr_pairs" +// suffix = ".mLb.clN" +// publish_dir = "bwa/mergedLibrary" +// publish_results = "all" +// publish_by_id = false +// } +// 'samtools_sort_filter' { +// args = "" +// suffix = ".mLb.clN.sorted" +// publish_dir = "bwa/mergedLibrary" +// publish_results = "all" +// publish_by_id = false +// } +// 'picard_collectmultiplemetrics' { +// args = "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" +// suffix = ".mLb.clN.sorted" +// publish_dir = "bwa/mergedLibrary/picard_metrics" +// publish_results = "all" +// publish_by_id = false +// } +// 'preseq_lcextrap' { +// args = "-verbose -bam -seed 1" +// suffix = ".mLb.clN" +// publish_dir = "bwa/mergedLibrary/preseq" +// publish_results = "all" +// publish_by_id = false +// } +// 'phantompeakqualtools' { +// args = "" +// suffix = ".mLb.clN" +// publish_dir = "bwa/mergedLibrary/phantompeakqualtools" +// publish_results = "all" +// publish_by_id = false +// } +// 'bedtools_genomecov' { +// args = "" +// suffix = ".mLb.clN" +// publish_dir = "bwa/mergedLibrary/bigwig" +// publish_results = "all" +// publish_by_id = false +// } +// 'ucsc_bedgraphtobigwig' { +// args = "" +// suffix = ".mLb.clN" +// publish_dir = "bwa/mergedLibrary/bigwig" +// publish_results = "all" +// publish_by_id = false +// } +// 'deeptools_computematrix' { +// args = "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels" +// suffix = ".mLb.clN" +// publish_dir = "bwa/mergedLibrary/deeptools" +// publish_results = "all" +// publish_by_id = false +// } +// 'deeptools_plotprofile' { +// args = "" +// suffix = ".mLb.clN" +// publish_dir = "bwa/mergedLibrary/deeptools" +// publish_results = "all" +// publish_by_id = false +// } +// 'deeptools_plotheatmap' { +// args = "" +// suffix = ".mLb.clN" +// publish_dir = "bwa/mergedLibrary/deeptools" +// publish_results = "all" +// publish_by_id = false +// } +// 'deeptools_plotfingerprint' { +// args = "--skipZeros" +// suffix = ".mLb.clN" +// publish_dir = "bwa/mergedLibrary/deeptools" +// publish_results = "all" +// publish_by_id = false +// } +// 'macs2_callpeak' { +// args = "--keep-dup all" +// suffix = "" +// publish_dir = "bwa/mergedLibrary/macs2" +// publish_results = "all" +// publish_by_id = false +// } +// 'plot_macs2_qc' { +// args = "-o ./ -p macs2_peak" +// suffix = "" +// publish_dir = "bwa/mergedLibrary/macs2" +// publish_results = "all" +// publish_by_id = false +// } +// 'homer_annotatepeaks_macs2' { +// args = "-gid" +// suffix = "_peaks" +// publish_dir = "bwa/mergedLibrary/macs2" +// publish_results = "all" +// publish_by_id = false +// } +// 'plot_homer_annotatepeaks' { +// args = "-o ./ -p macs2_annotatePeaks" +// suffix = "" +// publish_dir = "bwa/mergedLibrary/macs2" +// publish_results = "all" +// publish_by_id = false +// } +// 'macs2_consensus' { +// args = "" +// suffix = "" +// publish_dir = "bwa/mergedLibrary/macs2" +// publish_results = "all" +// publish_by_id = false +// } +// 'homer_annotatepeaks_consensus' { +// args = "-gid" +// suffix = "" +// publish_dir = "bwa/mergedLibrary/macs2" +// publish_results = "all" +// publish_by_id = true +// } +// 'get_software_versions' { +// args = "" +// suffix = "" +// publish_dir = "pipeline_info" +// publish_results = "all" +// publish_by_id = false +// } +// 'output_documentation' { +// args = "" +// suffix = "" +// publish_dir = "pipeline_info" +// publish_results = "all" +// publish_by_id = false +// } +// 'multiqc' { +// args = "" +// suffix = "" +// publish_dir = "multiqc" +// publish_results = "all" +// publish_by_id = false +// } +// } +// } From a906de8ceec303247e1bff085168f0b87e09bacc Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 29 Jul 2020 16:25:52 +0100 Subject: [PATCH 085/538] Refactor provision of module options --- conf/modules.config | 455 ++++++++++++++++++++------------------------ main.nf | 17 +- 2 files changed, 221 insertions(+), 251 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 7b7768754..5fb0526a7 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -4,257 +4,218 @@ * ------------------------------------------------- */ -def module_options_init(publish_dir="", args="", suffix="", publish_results="all", publish_by_id=false, args2="") { +// Function to initialise default values and to generate a Groovy Map of module options +def module_options (Map args) { def Map options = [:] - options.publish_dir = publish_dir - options.args = args - options.suffix = suffix - options.publish_results = publish_results - options.publish_by_id = publish_by_id - options.args2 = args2 + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_dir = args.publish_dir ?: '' + options.publish_results = args.publish_results ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.suffix = args.suffix ?: '' return options } def Map modules = [:] -modules['samplesheet_check'] = module_options_init(publish_dir="pipeline_info") -modules['fastqc'] = module_options_init(publish_dir="fastqc", args="--quiet") -modules['trimgalore'] = module_options_init(publish_dir="trimgalore", args="--fastqc") +modules['samplesheet_check'] = + module_options ( + publish_dir : "pipeline_info" + ) + +modules['fastqc'] = + module_options ( + args : "--quiet", + publish_dir : "fastqc" + ) + +modules['trimgalore'] = + module_options ( + args : "--fastqc", + publish_dir : "trimgalore" + ) + +modules['bwa_index'] = + module_options ( + args : "-a bwtsw", + publish_dir : "genome/bwa_index" + ) + +modules['gtf2bed'] = + module_options ( + publish_dir : "genome" + ) + +modules['make_genome_filter'] = + module_options ( + publish_dir : "genome" + ) + +modules['get_chrom_sizes'] = + module_options ( + publish_dir : "genome" + ) + +modules['bwa_mem'] = + module_options ( + args : "-M", + args2 : "-h -F 0x0100 -O BAM", + publish_dir : "bwa/library", + suffix : ".Lb" + ) + +modules['samtools_sort_lib'] = + module_options ( + publish_dir : "bwa/library", + suffix : ".Lb.sorted" + ) + +modules['picard_mergesamfiles'] = + module_options ( + args : "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp", + publish_dir : "bwa/mergedLibrary", + suffix : ".mLb.sorted" + ) + +modules['picard_markduplicates'] = + module_options ( + args : "ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp", + publish_dir : "bwa/mergedLibrary", + suffix : ".mLb.mkD.sorted" + ) + +modules['samtools_sort_merged_lib'] = + module_options ( + publish_dir : "bwa/mergedLibrary", + suffix : ".mLb.mkD.sorted" + ) + +modules['bam_filter'] = + module_options ( + publish_dir : "bwa/mergedLibrary", + suffix : ".mLb.flT.sorted" + ) + +modules['bam_remove_orphans'] = + module_options ( + args : "--only_fr_pairs", + publish_dir : "bwa/mergedLibrary", + suffix : ".mLb.clN" + ) + +modules['samtools_sort_filter'] = + module_options ( + publish_dir : "bwa/mergedLibrary", + suffix : ".mLb.clN.sorted" + ) + +modules['picard_collectmultiplemetrics'] = + module_options ( + args : "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp", + publish_dir : "bwa/mergedLibrary/picard_metrics", + suffix : ".mLb.clN.sorted" + ) + +modules['preseq_lcextrap'] = + module_options ( + args : "-verbose -bam -seed 1", + publish_dir : "bwa/mergedLibrary/preseq", + suffix : ".mLb.clN" + ) + +modules['phantompeakqualtools'] = + module_options ( + publish_dir : "bwa/mergedLibrary/phantompeakqualtools", + suffix : ".mLb.clN" + ) + +modules['bedtools_genomecov'] = + module_options ( + publish_dir : "bwa/mergedLibrary/bigwig", + suffix : ".mLb.clN" + ) + +modules['ucsc_bedgraphtobigwig'] = + module_options ( + publish_dir : "bwa/mergedLibrary/bigwig", + suffix : ".mLb.clN" + ) + +modules['deeptools_computematrix'] = + module_options ( + args : "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels", + publish_dir : "bwa/mergedLibrary/deeptools", + suffix : ".mLb.clN" + ) + +modules['deeptools_plotprofile'] = + module_options ( + publish_dir : "bwa/mergedLibrary/deeptools", + suffix : ".mLb.clN" + ) + +modules['deeptools_plotheatmap'] = + module_options ( + publish_dir : "bwa/mergedLibrary/deeptools", + suffix : ".mLb.clN" + ) + +modules['deeptools_plotfingerprint'] = + module_options ( + args : "--skipZeros", + publish_dir : "bwa/mergedLibrary/deeptools", + suffix : ".mLb.clN" + ) + +modules['macs2_callpeak'] = + module_options ( + args : "--keep-dup all", + publish_dir : "bwa/mergedLibrary/macs2" + ) + +modules['plot_macs2_qc'] = + module_options ( + args : "-o ./ -p macs2_peak", + publish_dir : "bwa/mergedLibrary/macs2" + ) + +modules['homer_annotatepeaks_macs2'] = + module_options ( + args : "-gid", + publish_dir : "bwa/mergedLibrary/macs2", + suffix : "_peaks" + ) + +modules['plot_homer_annotatepeaks'] = + module_options ( + args : "-o ./ -p macs2_annotatePeaks", + publish_dir : "bwa/mergedLibrary/macs2", + ) + +modules['macs2_consensus'] = + module_options ( + publish_dir : "bwa/mergedLibrary/macs2" + ) + +modules['homer_annotatepeaks_consensus'] = + module_options ( + args : "-gid", + publish_dir : "bwa/mergedLibrary/macs2", + publish_by_id : true + ) + +modules['get_software_versions'] = + module_options ( + publish_dir : "pipeline_info" + ) + +modules['output_documentation'] = + module_options ( + publish_dir : "pipeline_info" + ) + +modules['multiqc'] = + module_options ( + publish_dir : "multiqc" + ) params.modules = modules -println(params.modules) -// params { -// modules { -// // 'samplesheet_check' { -// // args = "" -// // suffix = "" -// // publish_dir = "pipeline_info" -// // publish_results = "all" -// // publish_by_id = false -// // } -// 'fastqc' { -// args = "--quiet" -// suffix = "" -// publish_dir = "fastqc" -// publish_results = "all" -// publish_by_id = false -// } -// 'trimgalore' { -// args = "--fastqc" -// suffix = "" -// publish_dir = "trim_galore" -// publish_results = "all" -// publish_by_id = false -// } -// 'bwa_index' { -// args = "-a bwtsw" -// suffix = "" -// publish_dir = "genome/bwa_index" -// publish_results = "all" -// publish_by_id = false -// } -// 'gtf2bed' { -// args = "" -// suffix = "" -// publish_dir = "genome" -// publish_results = "all" -// publish_by_id = false -// } -// 'make_genome_filter' { -// args = "" -// suffix = "" -// publish_dir = "genome" -// publish_results = "all" -// publish_by_id = false -// } -// 'get_chrom_sizes' { -// args = "" -// suffix = "" -// publish_dir = "genome" -// publish_results = "all" -// publish_by_id = false -// } -// 'bwa_mem' { -// args = "-M" -// args2 = "-h -F 0x0100 -O BAM" -// suffix = ".Lb" -// publish_dir = "bwa/library" -// publish_results = "all" -// publish_by_id = false -// } -// 'samtools_sort_lib' { -// args = "" -// suffix = ".Lb.sorted" -// publish_dir = "bwa/library" -// publish_results = "all" -// publish_by_id = false -// } -// 'picard_mergesamfiles' { -// args = "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" -// suffix = ".mLb.sorted" -// publish_dir = "bwa/mergedLibrary" -// publish_results = "all" -// publish_by_id = false -// } -// 'picard_markduplicates' { -// args = "ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" -// suffix = ".mLb.mkD.sorted" -// publish_dir = "bwa/mergedLibrary" -// publish_results = "all" -// publish_by_id = false -// } -// 'samtools_sort_merged_lib' { -// args = "" -// suffix = ".mLb.mkD.sorted" -// publish_dir = "bwa/mergedLibrary" -// publish_results = "all" -// publish_by_id = false -// } -// 'bam_filter' { -// args = "" -// suffix = ".mLb.flT.sorted" -// publish_dir = "bwa/mergedLibrary" -// publish_results = "all" -// publish_by_id = false -// } -// 'bam_remove_orphans' { -// args = "--only_fr_pairs" -// suffix = ".mLb.clN" -// publish_dir = "bwa/mergedLibrary" -// publish_results = "all" -// publish_by_id = false -// } -// 'samtools_sort_filter' { -// args = "" -// suffix = ".mLb.clN.sorted" -// publish_dir = "bwa/mergedLibrary" -// publish_results = "all" -// publish_by_id = false -// } -// 'picard_collectmultiplemetrics' { -// args = "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" -// suffix = ".mLb.clN.sorted" -// publish_dir = "bwa/mergedLibrary/picard_metrics" -// publish_results = "all" -// publish_by_id = false -// } -// 'preseq_lcextrap' { -// args = "-verbose -bam -seed 1" -// suffix = ".mLb.clN" -// publish_dir = "bwa/mergedLibrary/preseq" -// publish_results = "all" -// publish_by_id = false -// } -// 'phantompeakqualtools' { -// args = "" -// suffix = ".mLb.clN" -// publish_dir = "bwa/mergedLibrary/phantompeakqualtools" -// publish_results = "all" -// publish_by_id = false -// } -// 'bedtools_genomecov' { -// args = "" -// suffix = ".mLb.clN" -// publish_dir = "bwa/mergedLibrary/bigwig" -// publish_results = "all" -// publish_by_id = false -// } -// 'ucsc_bedgraphtobigwig' { -// args = "" -// suffix = ".mLb.clN" -// publish_dir = "bwa/mergedLibrary/bigwig" -// publish_results = "all" -// publish_by_id = false -// } -// 'deeptools_computematrix' { -// args = "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels" -// suffix = ".mLb.clN" -// publish_dir = "bwa/mergedLibrary/deeptools" -// publish_results = "all" -// publish_by_id = false -// } -// 'deeptools_plotprofile' { -// args = "" -// suffix = ".mLb.clN" -// publish_dir = "bwa/mergedLibrary/deeptools" -// publish_results = "all" -// publish_by_id = false -// } -// 'deeptools_plotheatmap' { -// args = "" -// suffix = ".mLb.clN" -// publish_dir = "bwa/mergedLibrary/deeptools" -// publish_results = "all" -// publish_by_id = false -// } -// 'deeptools_plotfingerprint' { -// args = "--skipZeros" -// suffix = ".mLb.clN" -// publish_dir = "bwa/mergedLibrary/deeptools" -// publish_results = "all" -// publish_by_id = false -// } -// 'macs2_callpeak' { -// args = "--keep-dup all" -// suffix = "" -// publish_dir = "bwa/mergedLibrary/macs2" -// publish_results = "all" -// publish_by_id = false -// } -// 'plot_macs2_qc' { -// args = "-o ./ -p macs2_peak" -// suffix = "" -// publish_dir = "bwa/mergedLibrary/macs2" -// publish_results = "all" -// publish_by_id = false -// } -// 'homer_annotatepeaks_macs2' { -// args = "-gid" -// suffix = "_peaks" -// publish_dir = "bwa/mergedLibrary/macs2" -// publish_results = "all" -// publish_by_id = false -// } -// 'plot_homer_annotatepeaks' { -// args = "-o ./ -p macs2_annotatePeaks" -// suffix = "" -// publish_dir = "bwa/mergedLibrary/macs2" -// publish_results = "all" -// publish_by_id = false -// } -// 'macs2_consensus' { -// args = "" -// suffix = "" -// publish_dir = "bwa/mergedLibrary/macs2" -// publish_results = "all" -// publish_by_id = false -// } -// 'homer_annotatepeaks_consensus' { -// args = "-gid" -// suffix = "" -// publish_dir = "bwa/mergedLibrary/macs2" -// publish_results = "all" -// publish_by_id = true -// } -// 'get_software_versions' { -// args = "" -// suffix = "" -// publish_dir = "pipeline_info" -// publish_results = "all" -// publish_by_id = false -// } -// 'output_documentation' { -// args = "" -// suffix = "" -// publish_dir = "pipeline_info" -// publish_results = "all" -// publish_by_id = false -// } -// 'multiqc' { -// args = "" -// suffix = "" -// publish_dir = "multiqc" -// publish_results = "all" -// publish_by_id = false -// } -// } -// } diff --git a/main.nf b/main.nf index 63d95c727..1946dffd3 100755 --- a/main.nf +++ b/main.nf @@ -163,7 +163,8 @@ include { DEEPTOOLS_PLOTHEATMAP } from './modules/nf-core/software/deept include { DEEPTOOLS_PLOTFINGERPRINT } from './modules/nf-core/software/deeptools_plotfingerprint' include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/software/phantompeakqualtools' include { MACS2_CALLPEAK } from './modules/nf-core/software/macs2_callpeak' -include { HOMER_ANNOTATEPEAKS } from './modules/nf-core/software/homer_annotatepeaks' +include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 + HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from './modules/nf-core/software/homer_annotatepeaks' //include { SUBREAD_FEATURECOUNTS } from './modules/nf-core/software/subread_featurecounts' include { FASTQC_TRIMGALORE } from './modules/nf-core/subworkflow/fastqc_trimgalore' @@ -388,17 +389,17 @@ workflow { ) params.modules['homer_annotatepeaks_macs2'].publish_dir += "/$peakType" - HOMER_ANNOTATEPEAKS ( + HOMER_ANNOTATEPEAKS_MACS2 ( MACS2_CALLPEAK.out.peak, ch_fasta, ch_gtf, params.modules['homer_annotatepeaks_macs2'] ) - ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS.out.version.first().ifEmpty(null)) + ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.version.first().ifEmpty(null)) params.modules['plot_homer_annotatepeaks'].publish_dir += "/$peakType/qc" PLOT_HOMER_ANNOTATEPEAKS ( - HOMER_ANNOTATEPEAKS.out.txt.collect{it[1]}, + HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, "_peaks.annotatePeaks.txt", params.modules['plot_homer_annotatepeaks'] ) @@ -430,6 +431,14 @@ workflow { params.modules['macs2_consensus'] ) + params.modules['homer_annotatepeaks_consensus'].publish_dir += "/$peakType/consensus" + HOMER_ANNOTATEPEAKS_CONSENSUS ( + MACS2_CONSENSUS.out.bed, + ch_fasta, + ch_gtf, + params.modules['homer_annotatepeaks_consensus'] + ) + //ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) } From 02d64210cd6c468129548ed70115391937b2548a Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 29 Jul 2020 17:38:12 +0100 Subject: [PATCH 086/538] test publish_by_id --- modules/nf-core/software/homer_annotatepeaks.nf | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf index cf09a4847..305056a82 100644 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ b/modules/nf-core/software/homer_annotatepeaks.nf @@ -4,7 +4,7 @@ def VERSION = '4.11' process HOMER_ANNOTATEPEAKS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${publish_id}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null @@ -28,6 +28,7 @@ process HOMER_ANNOTATEPEAKS { script: prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + publish_id = options.publish_by_id ? "/${meta.id}" : '' """ annotatePeaks.pl \\ $peak \\ From d71c4a63e0552c678f660956dbc434e49c3bb093 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 29 Jul 2020 18:06:16 +0100 Subject: [PATCH 087/538] Add module option to publish by id --- modules/nf-core/software/homer_annotatepeaks.nf | 3 +-- 1 file changed, 1 insertion(+), 2 deletions(-) diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf index 305056a82..c65a9ea49 100644 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ b/modules/nf-core/software/homer_annotatepeaks.nf @@ -4,7 +4,7 @@ def VERSION = '4.11' process HOMER_ANNOTATEPEAKS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${publish_id}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null @@ -28,7 +28,6 @@ process HOMER_ANNOTATEPEAKS { script: prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" - publish_id = options.publish_by_id ? "/${meta.id}" : '' """ annotatePeaks.pl \\ $peak \\ From 793251ecfa4ee4a9805857a3f7ff4010211c8fbe Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 29 Jul 2020 18:06:48 +0100 Subject: [PATCH 088/538] Rename annotated peaks --- conf/modules.config | 3 ++- main.nf | 39 ++------------------------------------- 2 files changed, 4 insertions(+), 38 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 5fb0526a7..633ae748a 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -200,7 +200,8 @@ modules['homer_annotatepeaks_consensus'] = module_options ( args : "-gid", publish_dir : "bwa/mergedLibrary/macs2", - publish_by_id : true + publish_by_id : true, + suffix : ".consensus_peaks" ) modules['get_software_versions'] = diff --git a/main.nf b/main.nf index 1946dffd3..22f4451c0 100755 --- a/main.nf +++ b/main.nf @@ -438,6 +438,8 @@ workflow { ch_gtf, params.modules['homer_annotatepeaks_consensus'] ) + // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt + // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt //ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) } @@ -516,43 +518,6 @@ workflow.onComplete { /* -- THE END -- */ //////////////////////////////////////////////////// -// -// /* -// * STEP 7.2: Annotate consensus peaks with HOMER, and add annotation to boolean output file -// */ -// process CONSENSUS_PEAKS_ANNOTATE { -// tag "${antibody}" -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}", mode: params.publish_dir_mode -// -// when: -// params.macs_gsize && (replicatesExist || multipleGroups) && !params.skip_consensus_peaks && !params.skip_peak_annotation -// -// input: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(bed) from ch_macs_consensus_bed -// path bool from ch_macs_consensus_bool -// path fasta from ch_fasta -// path gtf from ch_gtf -// -// output: -// path '*.annotatePeaks.txt' -// -// script: -// prefix = "${antibody}.consensus_peaks" -// """ -// annotatePeaks.pl \\ -// $bed \\ -// $fasta \\ -// -gid \\ -// -gtf $gtf \\ -// -cpu $task.cpus \\ -// > ${prefix}.annotatePeaks.txt -// -// cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt -// paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt -// """ -// } -// // // Get BAM and SAF files for each ip // ch_group_bam_counts // .map { it -> [ it[3], [ it[0], it[1], it[2] ] ] } From f4e292424599fdc5ce2601202fdf04f625ed73e0 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 29 Jul 2020 18:17:54 +0100 Subject: [PATCH 089/538] Add publish_by_id option --- modules/local/process/bam_filter.nf | 2 +- modules/local/process/bam_remove_orphans.nf | 2 +- modules/local/process/bedtools_genomecov.nf | 2 +- modules/local/process/macs2_consensus.nf | 2 +- modules/nf-core/software/bwa_mem.nf | 2 +- modules/nf-core/software/deeptools_computematrix.nf | 2 +- modules/nf-core/software/deeptools_plotfingerprint.nf | 2 +- modules/nf-core/software/deeptools_plotheatmap.nf | 2 +- modules/nf-core/software/deeptools_plotprofile.nf | 2 +- modules/nf-core/software/fastqc.nf | 2 +- modules/nf-core/software/macs2_callpeak.nf | 2 +- modules/nf-core/software/phantompeakqualtools.nf | 2 +- modules/nf-core/software/picard_collectmultiplemetrics.nf | 2 +- modules/nf-core/software/picard_markduplicates.nf | 2 +- modules/nf-core/software/picard_mergesamfiles.nf | 2 +- modules/nf-core/software/preseq_lcextrap.nf | 2 +- modules/nf-core/software/samtools_flagstat.nf | 2 +- modules/nf-core/software/samtools_idxstats.nf | 2 +- modules/nf-core/software/samtools_index.nf | 2 +- modules/nf-core/software/samtools_sort.nf | 2 +- modules/nf-core/software/samtools_stats.nf | 2 +- modules/nf-core/software/trimgalore.nf | 2 +- modules/nf-core/software/ucsc_bedgraphtobigwig.nf | 2 +- 23 files changed, 23 insertions(+), 23 deletions(-) diff --git a/modules/local/process/bam_filter.nf b/modules/local/process/bam_filter.nf index df4e9e90b..7edfd3339 100644 --- a/modules/local/process/bam_filter.nf +++ b/modules/local/process/bam_filter.nf @@ -4,7 +4,7 @@ process BAM_FILTER { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/local/process/bam_remove_orphans.nf b/modules/local/process/bam_remove_orphans.nf index 6aa109a4e..65b30d241 100644 --- a/modules/local/process/bam_remove_orphans.nf +++ b/modules/local/process/bam_remove_orphans.nf @@ -4,7 +4,7 @@ process BAM_REMOVE_ORPHANS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/local/process/bedtools_genomecov.nf b/modules/local/process/bedtools_genomecov.nf index 5a97667d4..5e60e76e5 100644 --- a/modules/local/process/bedtools_genomecov.nf +++ b/modules/local/process/bedtools_genomecov.nf @@ -3,7 +3,7 @@ def SOFTWARE = 'bedtools' process BEDTOOLS_GENOMECOV { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/local/process/macs2_consensus.nf b/modules/local/process/macs2_consensus.nf index 8abb2c515..ed26a5a86 100644 --- a/modules/local/process/macs2_consensus.nf +++ b/modules/local/process/macs2_consensus.nf @@ -4,7 +4,7 @@ process MACS2_CONSENSUS { tag "$meta.id" label 'process_long' - publishDir "${params.outdir}/${options.publish_dir}/${meta.id}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/bwa_mem.nf b/modules/nf-core/software/bwa_mem.nf index a0d350b3e..8f4e826ba 100644 --- a/modules/nf-core/software/bwa_mem.nf +++ b/modules/nf-core/software/bwa_mem.nf @@ -3,7 +3,7 @@ def SOFTWARE = 'bwa' process BWA_MEM { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/deeptools_computematrix.nf b/modules/nf-core/software/deeptools_computematrix.nf index e9b2ec06b..895afeb21 100644 --- a/modules/nf-core/software/deeptools_computematrix.nf +++ b/modules/nf-core/software/deeptools_computematrix.nf @@ -3,7 +3,7 @@ def SOFTWARE = 'deeptools' process DEEPTOOLS_COMPUTEMATRIX { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/deeptools_plotfingerprint.nf b/modules/nf-core/software/deeptools_plotfingerprint.nf index a7ecd0cb8..0b0663a51 100644 --- a/modules/nf-core/software/deeptools_plotfingerprint.nf +++ b/modules/nf-core/software/deeptools_plotfingerprint.nf @@ -3,7 +3,7 @@ def SOFTWARE = 'deeptools' process DEEPTOOLS_PLOTFINGERPRINT { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/deeptools_plotheatmap.nf b/modules/nf-core/software/deeptools_plotheatmap.nf index e12fa6c7e..5ded02db2 100644 --- a/modules/nf-core/software/deeptools_plotheatmap.nf +++ b/modules/nf-core/software/deeptools_plotheatmap.nf @@ -3,7 +3,7 @@ def SOFTWARE = 'deeptools' process DEEPTOOLS_PLOTHEATMAP { tag "$meta.id" label 'process_low' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/deeptools_plotprofile.nf b/modules/nf-core/software/deeptools_plotprofile.nf index a34de4cda..3932e0e66 100644 --- a/modules/nf-core/software/deeptools_plotprofile.nf +++ b/modules/nf-core/software/deeptools_plotprofile.nf @@ -3,7 +3,7 @@ def SOFTWARE = 'deeptools' process DEEPTOOLS_PLOTPROFILE { tag "$meta.id" label 'process_low' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/fastqc.nf b/modules/nf-core/software/fastqc.nf index f526e8d98..8d5f49825 100755 --- a/modules/nf-core/software/fastqc.nf +++ b/modules/nf-core/software/fastqc.nf @@ -3,7 +3,7 @@ def SOFTWARE = 'fastqc' process FASTQC { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf index f4bfac096..20e2a93f0 100644 --- a/modules/nf-core/software/macs2_callpeak.nf +++ b/modules/nf-core/software/macs2_callpeak.nf @@ -3,7 +3,7 @@ def SOFTWARE = 'macs2' process MACS2_CALLPEAK { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf index a6df15650..8d072bab2 100644 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ b/modules/nf-core/software/phantompeakqualtools.nf @@ -4,7 +4,7 @@ def VERSION = '1.2.2' process PHANTOMPEAKQUALTOOLS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/picard_collectmultiplemetrics.nf b/modules/nf-core/software/picard_collectmultiplemetrics.nf index 1f9dd9bab..80e0eacc2 100644 --- a/modules/nf-core/software/picard_collectmultiplemetrics.nf +++ b/modules/nf-core/software/picard_collectmultiplemetrics.nf @@ -3,7 +3,7 @@ def SOFTWARE = 'picard' process PICARD_COLLECTMULTIPLEMETRICS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf index 338e269b5..13abdd901 100644 --- a/modules/nf-core/software/picard_markduplicates.nf +++ b/modules/nf-core/software/picard_markduplicates.nf @@ -3,7 +3,7 @@ def SOFTWARE = 'picard' process PICARD_MARKDUPLICATES { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/picard_mergesamfiles.nf b/modules/nf-core/software/picard_mergesamfiles.nf index 2a4630a7b..5e81b5a52 100644 --- a/modules/nf-core/software/picard_mergesamfiles.nf +++ b/modules/nf-core/software/picard_mergesamfiles.nf @@ -3,7 +3,7 @@ def SOFTWARE = 'picard' process PICARD_MERGESAMFILES { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/preseq_lcextrap.nf b/modules/nf-core/software/preseq_lcextrap.nf index 4c9d24708..b5189911d 100644 --- a/modules/nf-core/software/preseq_lcextrap.nf +++ b/modules/nf-core/software/preseq_lcextrap.nf @@ -4,7 +4,7 @@ process PRESEQ_LCEXTRAP { tag "$meta.id" label 'process_medium' label 'error_ignore' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/samtools_flagstat.nf b/modules/nf-core/software/samtools_flagstat.nf index 8a17bba19..b7f066653 100644 --- a/modules/nf-core/software/samtools_flagstat.nf +++ b/modules/nf-core/software/samtools_flagstat.nf @@ -2,7 +2,7 @@ def SOFTWARE = 'samtools' process SAMTOOLS_FLAGSTAT { tag "$meta.id" - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/samtools_idxstats.nf b/modules/nf-core/software/samtools_idxstats.nf index 0dab14709..2462c0a21 100644 --- a/modules/nf-core/software/samtools_idxstats.nf +++ b/modules/nf-core/software/samtools_idxstats.nf @@ -2,7 +2,7 @@ def SOFTWARE = 'samtools' process SAMTOOLS_IDXSTATS { tag "$meta.id" - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/samtools_index.nf b/modules/nf-core/software/samtools_index.nf index 372a3d994..7baafd525 100644 --- a/modules/nf-core/software/samtools_index.nf +++ b/modules/nf-core/software/samtools_index.nf @@ -2,7 +2,7 @@ def SOFTWARE = 'samtools' process SAMTOOLS_INDEX { tag "$meta.id" - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/samtools_sort.nf b/modules/nf-core/software/samtools_sort.nf index 0249ee3cf..8e665bb17 100644 --- a/modules/nf-core/software/samtools_sort.nf +++ b/modules/nf-core/software/samtools_sort.nf @@ -3,7 +3,7 @@ def SOFTWARE = 'samtools' process SAMTOOLS_SORT { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/samtools_stats.nf b/modules/nf-core/software/samtools_stats.nf index e1ddb90c8..1a8d84d07 100644 --- a/modules/nf-core/software/samtools_stats.nf +++ b/modules/nf-core/software/samtools_stats.nf @@ -2,7 +2,7 @@ def SOFTWARE = 'samtools' process SAMTOOLS_STATS { tag "$meta.id" - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/trimgalore.nf b/modules/nf-core/software/trimgalore.nf index b740fbc43..130bc90ee 100644 --- a/modules/nf-core/software/trimgalore.nf +++ b/modules/nf-core/software/trimgalore.nf @@ -3,7 +3,7 @@ def SOFTWARE = 'trimgalore' process TRIMGALORE { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null diff --git a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf index 5059e4313..43b9b16ce 100644 --- a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf +++ b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf @@ -4,7 +4,7 @@ def VERSION = '377' process UCSC_BEDRAPHTOBIGWIG { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, saveAs: { filename -> if (options.publish_results == "none") null From ce414f1475076a513b7a70e30880c163101965f3 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 29 Jul 2020 18:25:51 +0100 Subject: [PATCH 090/538] Tidy up main script --- main.nf | 17 ----------------- 1 file changed, 17 deletions(-) diff --git a/main.nf b/main.nf index 22f4451c0..cc87df977 100755 --- a/main.nf +++ b/main.nf @@ -444,7 +444,6 @@ workflow { //ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) } - /* * Pipeline reporting */ @@ -617,14 +616,6 @@ workflow.onComplete { // """ // } // -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// /* -- -- */ -// /* -- IGV -- */ -// /* -- -- */ -// /////////////////////////////////////////////////////////////////////////////// -// /////////////////////////////////////////////////////////////////////////////// -// // /* // * STEP 8: Create IGV session file // */ @@ -650,11 +641,3 @@ workflow.onComplete { // igv_files_to_session.py igv_session.xml igv_files.txt ../../genome/${fasta.getName()} --path_prefix '../../' // """ // } - -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// -/* -- -- */ -/* -- END OF PIPELINE -- */ -/* -- -- */ -/////////////////////////////////////////////////////////////////////////////// -/////////////////////////////////////////////////////////////////////////////// From b2a129148bc0f3ec0ee46b5a1496052dd842baa4 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 29 Jul 2020 21:47:02 +0100 Subject: [PATCH 091/538] Update env to get release tests passing --- environment.yml | 28 +++++++++++++++++++++------- 1 file changed, 21 insertions(+), 7 deletions(-) diff --git a/environment.yml b/environment.yml index 361352d0c..e1cce55c3 100644 --- a/environment.yml +++ b/environment.yml @@ -7,11 +7,11 @@ channels: - defaults dependencies: ## conda-forge packages - - conda-forge::python=3.7.8 + - conda-forge::python=3.7.6 - conda-forge::markdown=3.2.2 - conda-forge::pymdown-extensions=7.1 - conda-forge::pygments=2.6.1 - - conda-forge::r-base=4.0.2 + - conda-forge::r-base=3.6.2 - conda-forge::r-optparse=1.6.6 - conda-forge::r-rcolorbrewer=1.1_2 - conda-forge::r-reshape2=1.4.4 @@ -21,13 +21,27 @@ dependencies: - conda-forge::r-pheatmap=1.0.12 - conda-forge::r-lattice=0.20_41 - conda-forge::r-upsetr=1.4.0 - - conda-forge::r-xfun=0.16 + - conda-forge::r-xfun=0.15 + - conda-forge::gawk=5.1.0 + - conda-forge::pigz=2.3.4 ## Required for TrimGalore multi-threading ## bioconda packages + - bioconda::fastqc=0.11.9 + - bioconda::trim-galore=0.6.5 + - bioconda::bwa=0.7.17 - bioconda::samtools=1.10 + - bioconda::picard=2.23.1 - bioconda::bamtools=2.5.1 - - bioconda::pysam=0.16.0.1 + - bioconda::pysam=0.15.3 - bioconda::bedtools=2.29.2 - - bioconda::bioconductor-biocparallel=1.22.0 - - bioconda::bioconductor-deseq2=1.28.0 - - bioconda::bioconductor-vsn=3.56.0 + - bioconda::ucsc-bedgraphtobigwig=357 + - bioconda::deeptools=3.4.3 + - bioconda::macs2=2.2.7.1 + - bioconda::homer=4.11 + - bioconda::subread=2.0.1 + - bioconda::phantompeakqualtools=1.2.2 + - bioconda::preseq=2.0.3 + - bioconda::multiqc=1.9 + - bioconda::bioconductor-biocparallel=1.20.0 + - bioconda::bioconductor-deseq2=1.26.0 + - bioconda::bioconductor-vsn=3.54.0 From 57b4a5bf4a935a9882228c4fbc5c8f28f64643af Mon Sep 17 00:00:00 2001 From: drpatelh Date: Thu, 30 Jul 2020 18:26:33 +0100 Subject: [PATCH 092/538] Update environment --- conf/modules.config | 17 +++++++++++++++++ environment.yml | 28 +++++++--------------------- 2 files changed, 24 insertions(+), 21 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 633ae748a..6d9425a83 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -204,6 +204,23 @@ modules['homer_annotatepeaks_consensus'] = suffix : ".consensus_peaks" ) +modules['subread_featurecounts'] = + module_options ( + args : "-F SAF -O --fracOverlap 0.2", + publish_dir : "bwa/mergedLibrary/macs2", + suffix : "" + ) + +modules['deseq2_featurecounts'] = + module_options ( + publish_dir : "bwa/mergedLibrary/macs2" + ) + +modules['igv'] = + module_options ( + publish_dir : "igv" + ) + modules['get_software_versions'] = module_options ( publish_dir : "pipeline_info" diff --git a/environment.yml b/environment.yml index e1cce55c3..361352d0c 100644 --- a/environment.yml +++ b/environment.yml @@ -7,11 +7,11 @@ channels: - defaults dependencies: ## conda-forge packages - - conda-forge::python=3.7.6 + - conda-forge::python=3.7.8 - conda-forge::markdown=3.2.2 - conda-forge::pymdown-extensions=7.1 - conda-forge::pygments=2.6.1 - - conda-forge::r-base=3.6.2 + - conda-forge::r-base=4.0.2 - conda-forge::r-optparse=1.6.6 - conda-forge::r-rcolorbrewer=1.1_2 - conda-forge::r-reshape2=1.4.4 @@ -21,27 +21,13 @@ dependencies: - conda-forge::r-pheatmap=1.0.12 - conda-forge::r-lattice=0.20_41 - conda-forge::r-upsetr=1.4.0 - - conda-forge::r-xfun=0.15 - - conda-forge::gawk=5.1.0 - - conda-forge::pigz=2.3.4 ## Required for TrimGalore multi-threading + - conda-forge::r-xfun=0.16 ## bioconda packages - - bioconda::fastqc=0.11.9 - - bioconda::trim-galore=0.6.5 - - bioconda::bwa=0.7.17 - bioconda::samtools=1.10 - - bioconda::picard=2.23.1 - bioconda::bamtools=2.5.1 - - bioconda::pysam=0.15.3 + - bioconda::pysam=0.16.0.1 - bioconda::bedtools=2.29.2 - - bioconda::ucsc-bedgraphtobigwig=357 - - bioconda::deeptools=3.4.3 - - bioconda::macs2=2.2.7.1 - - bioconda::homer=4.11 - - bioconda::subread=2.0.1 - - bioconda::phantompeakqualtools=1.2.2 - - bioconda::preseq=2.0.3 - - bioconda::multiqc=1.9 - - bioconda::bioconductor-biocparallel=1.20.0 - - bioconda::bioconductor-deseq2=1.26.0 - - bioconda::bioconductor-vsn=3.54.0 + - bioconda::bioconductor-biocparallel=1.22.0 + - bioconda::bioconductor-deseq2=1.28.0 + - bioconda::bioconductor-vsn=3.56.0 From 7eb4842cc8beb76298df8be82f222e09be14a556 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Thu, 30 Jul 2020 18:26:49 +0100 Subject: [PATCH 093/538] Add in featurecounts --- modules/local/process/multiqc.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/modules/local/process/multiqc.nf b/modules/local/process/multiqc.nf index 513886bb9..0f2572091 100755 --- a/modules/local/process/multiqc.nf +++ b/modules/local/process/multiqc.nf @@ -52,7 +52,7 @@ process MULTIQC { // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) // path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) - // path ('macs/consensus/*') from ch_macs_consensus_counts_mqc.collect().ifEmpty([]) + path ('featurecounts/*') // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) val options From fb22ea032fc237cf4dee1d5191b2c93fb5910008 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Thu, 30 Jul 2020 18:27:03 +0100 Subject: [PATCH 094/538] Get featurecounts working --- .../nf-core/software/subread_featurecounts.nf | 78 +++++++++---------- 1 file changed, 39 insertions(+), 39 deletions(-) diff --git a/modules/nf-core/software/subread_featurecounts.nf b/modules/nf-core/software/subread_featurecounts.nf index 536aa7e8b..36d38da01 100644 --- a/modules/nf-core/software/subread_featurecounts.nf +++ b/modules/nf-core/software/subread_featurecounts.nf @@ -1,41 +1,41 @@ def SOFTWARE = 'subread' -container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" -//container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" -//echo \$(featureCounts -v 2>&1) > featurecounts.version.txt -conda (params.conda ? "bioconda::subread=2.0.1" : null) -//echo \$(featureCounts -v 2>&1) | sed -e "s/featureCounts v//g" > ${SOFTWARE}.version.txt -// /* -// * STEP 7.3: Count reads in consensus peaks with featureCounts -// */ -// process CONSENSUS_PEAKS_COUNTS { -// tag "${antibody}" -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}", mode: params.publish_dir_mode -// -// when: -// params.macs_gsize && (replicatesExist || multipleGroups) && !params.skip_consensus_peaks -// -// input: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(bams), path(saf) from ch_group_bam_counts -// -// output: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), path('*featureCounts.txt') into ch_macs_consensus_counts -// path '*featureCounts.txt.summary' into ch_macs_consensus_counts_mqc -// -// script: -// prefix = "${antibody}.consensus_peaks" -// bam_files = bams.findAll { it.toString().endsWith('.bam') }.sort() -// pe_params = params.single_end ? '' : '-p --donotsort' -// """ -// featureCounts \\ -// -F SAF \\ -// -O \\ -// --fracOverlap 0.2 \\ -// -T $task.cpus \\ -// $pe_params \\ -// -a $saf \\ -// -o ${prefix}.featureCounts.txt \\ -// ${bam_files.join(' ')} -// """ -// } +process SUBREAD_FEATURECOUNTS { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (options.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" + //container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" + + conda (params.conda ? "bioconda::subread=2.0.1" : null) + + input: + tuple val(meta), path(bams), path(annotation) + val options + + output: + tuple val(meta), path("*featureCounts.txt"), emit: txt + tuple val(meta), path("*featureCounts.txt.summary"), emit: summary + path "*.version.txt", emit: version + + script: + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + pe = meta.single_end ? '' : '-p' + """ + featureCounts \\ + $options.args \\ + $pe \\ + -T $task.cpus \\ + -a $annotation \\ + -o ${prefix}.featureCounts.txt \\ + ${bams.join(' ')} + + echo \$(featureCounts -v 2>&1) | sed -e "s/featureCounts v//g" > ${SOFTWARE}.version.txt + """ +} From 35e345af5016b1014503a66db683192afabc7dfd Mon Sep 17 00:00:00 2001 From: drpatelh Date: Thu, 30 Jul 2020 18:27:13 +0100 Subject: [PATCH 095/538] Initial commit --- modules/local/process/deseq2_featurecounts.nf | 55 +++++++++++++++++++ 1 file changed, 55 insertions(+) create mode 100644 modules/local/process/deseq2_featurecounts.nf diff --git a/modules/local/process/deseq2_featurecounts.nf b/modules/local/process/deseq2_featurecounts.nf new file mode 100644 index 000000000..4586ee7e1 --- /dev/null +++ b/modules/local/process/deseq2_featurecounts.nf @@ -0,0 +1,55 @@ +conda (params.conda ? "${baseDir}/environment.yml" : null) + +// /* +// * STEP 7.4: Differential analysis with DESeq2 +// */ +// process CONSENSUS_PEAKS_DESEQ2 { +// tag "${antibody}" +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (filename.endsWith('.igv.txt')) null +// else filename +// } +// +// when: +// params.macs_gsize && replicatesExist && multipleGroups && !params.skip_consensus_peaks && !params.skip_diff_analysis +// +// input: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(counts) from ch_macs_consensus_counts +// path deseq2_pca_header from ch_deseq2_pca_header +// path deseq2_clustering_header from ch_deseq2_clustering_header +// +// output: +// path '*.tsv' into ch_macs_consensus_deseq_mqc +// path '*igv.txt' into ch_macs_consensus_deseq_comp_igv +// path '*.{RData,results.txt,pdf,log}' +// path 'sizeFactors' +// path '*vs*/*.{pdf,txt}' +// path '*vs*/*.bed' +// +// script: +// prefix = "${antibody}.consensus_peaks" +// bam_ext = params.single_end ? '.mLb.clN.sorted.bam' : '.mLb.clN.bam' +// vst = params.deseq2_vst ? '--vst TRUE' : '' +// """ +// featurecounts_deseq2.r \\ +// --featurecount_file $counts \\ +// --bam_suffix '$bam_ext' \\ +// --outdir ./ \\ +// --outprefix $prefix \\ +// --outsuffix '' \\ +// --cores $task.cpus \\ +// $vst +// +// sed 's/deseq2_pca/deseq2_pca_${task.index}/g' <$deseq2_pca_header >tmp.txt +// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt +// cat tmp.txt ${prefix}.pca.vals.txt > ${prefix}.pca.vals_mqc.tsv +// +// sed 's/deseq2_clustering/deseq2_clustering_${task.index}/g' <$deseq2_clustering_header >tmp.txt +// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt +// cat tmp.txt ${prefix}.sample.dists.txt > ${prefix}.sample.dists_mqc.tsv +// +// find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt +// """ +// } From d6a87840f8a8afd945095d05de8eb210fb5cbc07 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Thu, 30 Jul 2020 18:27:27 +0100 Subject: [PATCH 096/538] Rename for grouping --- modules/local/process/featurecounts_deseq2.nf | 55 ------------------- 1 file changed, 55 deletions(-) delete mode 100644 modules/local/process/featurecounts_deseq2.nf diff --git a/modules/local/process/featurecounts_deseq2.nf b/modules/local/process/featurecounts_deseq2.nf deleted file mode 100644 index 4586ee7e1..000000000 --- a/modules/local/process/featurecounts_deseq2.nf +++ /dev/null @@ -1,55 +0,0 @@ -conda (params.conda ? "${baseDir}/environment.yml" : null) - -// /* -// * STEP 7.4: Differential analysis with DESeq2 -// */ -// process CONSENSUS_PEAKS_DESEQ2 { -// tag "${antibody}" -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (filename.endsWith('.igv.txt')) null -// else filename -// } -// -// when: -// params.macs_gsize && replicatesExist && multipleGroups && !params.skip_consensus_peaks && !params.skip_diff_analysis -// -// input: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(counts) from ch_macs_consensus_counts -// path deseq2_pca_header from ch_deseq2_pca_header -// path deseq2_clustering_header from ch_deseq2_clustering_header -// -// output: -// path '*.tsv' into ch_macs_consensus_deseq_mqc -// path '*igv.txt' into ch_macs_consensus_deseq_comp_igv -// path '*.{RData,results.txt,pdf,log}' -// path 'sizeFactors' -// path '*vs*/*.{pdf,txt}' -// path '*vs*/*.bed' -// -// script: -// prefix = "${antibody}.consensus_peaks" -// bam_ext = params.single_end ? '.mLb.clN.sorted.bam' : '.mLb.clN.bam' -// vst = params.deseq2_vst ? '--vst TRUE' : '' -// """ -// featurecounts_deseq2.r \\ -// --featurecount_file $counts \\ -// --bam_suffix '$bam_ext' \\ -// --outdir ./ \\ -// --outprefix $prefix \\ -// --outsuffix '' \\ -// --cores $task.cpus \\ -// $vst -// -// sed 's/deseq2_pca/deseq2_pca_${task.index}/g' <$deseq2_pca_header >tmp.txt -// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt -// cat tmp.txt ${prefix}.pca.vals.txt > ${prefix}.pca.vals_mqc.tsv -// -// sed 's/deseq2_clustering/deseq2_clustering_${task.index}/g' <$deseq2_clustering_header >tmp.txt -// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt -// cat tmp.txt ${prefix}.sample.dists.txt > ${prefix}.sample.dists_mqc.tsv -// -// find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt -// """ -// } From ab08373600001e89f43053cf97622606ff80257d Mon Sep 17 00:00:00 2001 From: drpatelh Date: Thu, 30 Jul 2020 18:27:37 +0100 Subject: [PATCH 097/538] Fix featurecounts --- main.nf | 188 ++++++++++++++++---------------------------------------- 1 file changed, 52 insertions(+), 136 deletions(-) diff --git a/main.nf b/main.nf index cc87df977..4497bf105 100755 --- a/main.nf +++ b/main.nf @@ -140,7 +140,9 @@ include { BEDTOOLS_GENOMECOV } from './modules/local/process/bedtools_geno include { PLOT_HOMER_ANNOTATEPEAKS } from './modules/local/process/plot_homer_annotatepeaks' include { PLOT_MACS2_QC } from './modules/local/process/plot_macs2_qc' include { MACS2_CONSENSUS } from './modules/local/process/macs2_consensus' -// include { FRIP_SCORE } from './modules/local/process/frip_score' +//include { FRIP_SCORE } from './modules/local/process/frip_score' +//include { DESEQ2_FEATURECOUNTS } from './modules/local/process/deseq2_featurecounts' +//include { IGV } from './modules/local/process/igv' include { OUTPUT_DOCUMENTATION } from './modules/local/process/output_documentation' include { GET_SOFTWARE_VERSIONS } from './modules/local/process/get_software_versions' include { MULTIQC } from './modules/local/process/multiqc' @@ -165,7 +167,7 @@ include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/software/phant include { MACS2_CALLPEAK } from './modules/nf-core/software/macs2_callpeak' include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from './modules/nf-core/software/homer_annotatepeaks' -//include { SUBREAD_FEATURECOUNTS } from './modules/nf-core/software/subread_featurecounts' +include { SUBREAD_FEATURECOUNTS } from './modules/nf-core/software/subread_featurecounts' include { FASTQC_TRIMGALORE } from './modules/nf-core/subworkflow/fastqc_trimgalore' include { MAP_BWA_MEM } from './modules/nf-core/subworkflow/map_bwa_mem' @@ -337,23 +339,23 @@ workflow { .bam .join ( BAM_CLEAN.out.bai, by: [0] ) .map { meta, bam, bai -> meta.control ? null : [ meta.id, [ bam ] , [ bai ] ] } - .set { ch_ip_control_bam } + .set { ch_control_bam_bai } BAM_CLEAN .out .bam .join ( BAM_CLEAN.out.bai, by: [0] ) .map { meta, bam, bai -> meta.control ? [ meta.control, meta, [ bam ], [ bai ] ] : null } - .combine(ch_ip_control_bam, by: 0) + .combine(ch_control_bam_bai, by: 0) .map { it -> [ it[1] , it[2] + it[4], it[3] + it[5] ] } - .set { ch_ip_control_bam } + .set { ch_ip_control_bam_bai } /* * plotFingerprint for IP and control together */ params.modules['deeptools_plotfingerprint'].args += " --numberOfSamples $params.fingerprint_bins" DEEPTOOLS_PLOTFINGERPRINT ( - ch_ip_control_bam, + ch_ip_control_bam_bai, params.modules['deeptools_plotfingerprint'] ) @@ -371,8 +373,8 @@ workflow { params.modules['macs2_callpeak'].args += " $broad $pileup $fdr $pvalue" // Create channel: [ val(meta), ip_bam, control_bam ] - ch_ip_control_bam - .map { it -> [ it[0] , it[1][0], it[1][1] ] } + ch_ip_control_bam_bai + .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } .set { ch_ip_control_bam } MACS2_CALLPEAK ( @@ -409,7 +411,7 @@ workflow { MACS2_CALLPEAK .out .peak - .map { meta, peak -> [ meta.antibody , meta.id.split('_')[0..-2].join('_'), peak ] } + .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } .groupTuple() .map { antibody, groups, peaks -> @@ -441,9 +443,48 @@ workflow { // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt - //ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) + // Create channel: [ val(meta), ip_bam ] + MACS2_CONSENSUS + .out + .saf + .map { meta, saf -> [ meta.id, meta, saf ] } + .set { ch_ip_saf } + + ch_ip_control_bam + .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } + .combine(ch_ip_saf) + .map { + it -> + fmeta = it[1] + fmeta['replicates_exist'] = it[4]['replicates_exist'] + fmeta['multiple_groups'] = it[4]['multiple_groups'] + [ fmeta, it[2], it[5] ] } + .set { ch_ip_bam } + + params.modules['subread_featurecounts'].publish_dir += "/$peakType/consensus" + SUBREAD_FEATURECOUNTS ( + ch_ip_bam, + params.modules['subread_featurecounts'] + ) + ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) + + // FRIP_SCORE ( + // params.modules['frip_score'] + // ) + // + // DESEQ2_FEATURECOUNTS ( + // params.modules['deseq2_featurecounts'] + // ) + } + // /* + // * Create IGV session + // */ + // IGV ( + // params.modules['igv'] + // ) + /* * Pipeline reporting */ @@ -496,7 +537,7 @@ workflow { // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) // path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) - // path ('macs/consensus/*') from ch_macs_consensus_counts_mqc.collect().ifEmpty([]) + SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) params.modules['multiqc'] @@ -516,128 +557,3 @@ workflow.onComplete { //////////////////////////////////////////////////// /* -- THE END -- */ //////////////////////////////////////////////////// - -// // Get BAM and SAF files for each ip -// ch_group_bam_counts -// .map { it -> [ it[3], [ it[0], it[1], it[2] ] ] } -// .join(ch_rm_orphan_name_bam_counts) -// .map { it -> [ it[1][0], it[1][1], it[1][2], it[2] ] } -// .groupTuple() -// .map { it -> [ it[0], it[1][0], it[2][0], it[3].flatten().sort() ] } -// .join(ch_macs_consensus_saf) -// .set { ch_group_bam_counts } -// -// /* -// * STEP 7.3: Count reads in consensus peaks with featureCounts -// */ -// process CONSENSUS_PEAKS_COUNTS { -// tag "${antibody}" -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}", mode: params.publish_dir_mode -// -// when: -// params.macs_gsize && (replicatesExist || multipleGroups) && !params.skip_consensus_peaks -// -// input: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(bams), path(saf) from ch_group_bam_counts -// -// output: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), path('*featureCounts.txt') into ch_macs_consensus_counts -// path '*featureCounts.txt.summary' into ch_macs_consensus_counts_mqc -// -// script: -// prefix = "${antibody}.consensus_peaks" -// bam_files = bams.findAll { it.toString().endsWith('.bam') }.sort() -// pe_params = params.single_end ? '' : '-p --donotsort' -// """ -// featureCounts \\ -// -F SAF \\ -// -O \\ -// --fracOverlap 0.2 \\ -// -T $task.cpus \\ -// $pe_params \\ -// -a $saf \\ -// -o ${prefix}.featureCounts.txt \\ -// ${bam_files.join(' ')} -// """ -// } -// -// /* -// * STEP 7.4: Differential analysis with DESeq2 -// */ -// process CONSENSUS_PEAKS_DESEQ2 { -// tag "${antibody}" -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (filename.endsWith('.igv.txt')) null -// else filename -// } -// -// when: -// params.macs_gsize && replicatesExist && multipleGroups && !params.skip_consensus_peaks && !params.skip_diff_analysis -// -// input: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(counts) from ch_macs_consensus_counts -// path deseq2_pca_header from ch_deseq2_pca_header -// path deseq2_clustering_header from ch_deseq2_clustering_header -// -// output: -// path '*.tsv' into ch_macs_consensus_deseq_mqc -// path '*igv.txt' into ch_macs_consensus_deseq_comp_igv -// path '*.{RData,results.txt,pdf,log}' -// path 'sizeFactors' -// path '*vs*/*.{pdf,txt}' -// path '*vs*/*.bed' -// -// script: -// prefix = "${antibody}.consensus_peaks" -// bam_ext = params.single_end ? '.mLb.clN.sorted.bam' : '.mLb.clN.bam' -// vst = params.deseq2_vst ? '--vst TRUE' : '' -// """ -// featurecounts_deseq2.r \\ -// --featurecount_file $counts \\ -// --bam_suffix '$bam_ext' \\ -// --outdir ./ \\ -// --outprefix $prefix \\ -// --outsuffix '' \\ -// --cores $task.cpus \\ -// $vst -// -// sed 's/deseq2_pca/deseq2_pca_${task.index}/g' <$deseq2_pca_header >tmp.txt -// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt -// cat tmp.txt ${prefix}.pca.vals.txt > ${prefix}.pca.vals_mqc.tsv -// -// sed 's/deseq2_clustering/deseq2_clustering_${task.index}/g' <$deseq2_clustering_header >tmp.txt -// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt -// cat tmp.txt ${prefix}.sample.dists.txt > ${prefix}.sample.dists_mqc.tsv -// -// find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt -// """ -// } -// -// /* -// * STEP 8: Create IGV session file -// */ -// process IGV { -// publishDir "${params.outdir}/igv/${PEAK_TYPE}", mode: params.publish_dir_mode -// -// when: -// !params.skip_igv -// -// input: -// path fasta from ch_fasta -// path bigwigs from ch_bigwig_igv.collect().ifEmpty([]) -// path peaks from ch_macs_igv.collect().ifEmpty([]) -// path consensus_peaks from ch_macs_consensus_igv.collect().ifEmpty([]) -// path differential_peaks from ch_macs_consensus_deseq_comp_igv.collect().ifEmpty([]) -// -// output: -// path '*.{txt,xml}' -// -// script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ -// """ -// cat *.txt > igv_files.txt -// igv_files_to_session.py igv_session.xml igv_files.txt ../../genome/${fasta.getName()} --path_prefix '../../' -// """ -// } From 1fd168a378367d17865efc33183a4cbd93d8ee78 Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Thu, 30 Jul 2020 20:05:16 +0000 Subject: [PATCH 098/538] Template update for nf-core/tools version 1.10.1 --- .github/.dockstore.yml | 5 + .github/CONTRIBUTING.md | 2 +- .github/ISSUE_TEMPLATE/bug_report.md | 15 +- .github/ISSUE_TEMPLATE/feature_request.md | 12 +- .github/PULL_REQUEST_TEMPLATE.md | 15 +- .github/workflows/awsfulltest.yml | 40 ++++ .github/workflows/awstest.yml | 40 ++++ .github/workflows/branch.yml | 30 ++- .github/workflows/ci.yml | 47 +++- .github/workflows/linting.yml | 13 +- .github/workflows/push_dockerhub.yml | 39 ++++ .gitignore | 1 + CHANGELOG.md | 8 +- CODE_OF_CONDUCT.md | 6 +- Dockerfile | 12 +- README.md | 42 ++-- bin/markdown_to_html.py | 43 ++-- bin/scrape_software_versions.py | 36 +-- conf/igenomes.config | 1 + conf/test.config | 2 +- conf/test_full.config | 22 ++ docs/README.md | 20 +- docs/output.md | 50 ++-- docs/usage.md | 272 +++------------------- environment.yml | 2 +- main.nf | 53 +++-- nextflow.config | 9 +- nextflow_schema.json | 259 ++++++++++++++++++++ 28 files changed, 685 insertions(+), 411 deletions(-) create mode 100644 .github/.dockstore.yml create mode 100644 .github/workflows/awsfulltest.yml create mode 100644 .github/workflows/awstest.yml create mode 100644 .github/workflows/push_dockerhub.yml create mode 100644 conf/test_full.config create mode 100644 nextflow_schema.json diff --git a/.github/.dockstore.yml b/.github/.dockstore.yml new file mode 100644 index 000000000..030138a0c --- /dev/null +++ b/.github/.dockstore.yml @@ -0,0 +1,5 @@ +# Dockstore config version, not pipeline version +version: 1.2 +workflows: + - subclass: nfl + primaryDescriptorPath: /nextflow.config diff --git a/.github/CONTRIBUTING.md b/.github/CONTRIBUTING.md index 484c13c31..6ab73766c 100644 --- a/.github/CONTRIBUTING.md +++ b/.github/CONTRIBUTING.md @@ -54,4 +54,4 @@ These tests are run both with the latest available version of `Nextflow` and als ## Getting help -For further information/help, please consult the [nf-core/chipseq documentation](https://nf-co.re/nf-core/chipseq/docs) and don't hesitate to get in touch on the nf-core Slack [#chipseq](https://nfcore.slack.com/channels/chipseq) channel ([join our Slack here](https://nf-co.re/join/slack)). +For further information/help, please consult the [nf-core/chipseq documentation](https://nf-co.re/chipseq/docs) and don't hesitate to get in touch on the nf-core Slack [#chipseq](https://nfcore.slack.com/channels/chipseq) channel ([join our Slack here](https://nf-co.re/join/slack)). diff --git a/.github/ISSUE_TEMPLATE/bug_report.md b/.github/ISSUE_TEMPLATE/bug_report.md index f394683ed..7781a9117 100644 --- a/.github/ISSUE_TEMPLATE/bug_report.md +++ b/.github/ISSUE_TEMPLATE/bug_report.md @@ -1,24 +1,27 @@ + -## Describe the bug +## Description of the bug -A clear and concise description of what the bug is. + ## Steps to reproduce Steps to reproduce the behaviour: -1. Command line: `nextflow run ...` -2. See error: _Please provide your error message_ +1. Command line: +2. See error: ## Expected behaviour -A clear and concise description of what you expected to happen. + ## System @@ -39,4 +42,4 @@ A clear and concise description of what you expected to happen. ## Additional context -Add any other context about the problem here. + diff --git a/.github/ISSUE_TEMPLATE/feature_request.md b/.github/ISSUE_TEMPLATE/feature_request.md index c3bbf1942..1f5a0971a 100644 --- a/.github/ISSUE_TEMPLATE/feature_request.md +++ b/.github/ISSUE_TEMPLATE/feature_request.md @@ -1,24 +1,26 @@ + ## Is your feature request related to a problem? Please describe -A clear and concise description of what the problem is. + -Ex. I'm always frustrated when [...] + ## Describe the solution you'd like -A clear and concise description of what you want to happen. + ## Describe alternatives you've considered -A clear and concise description of any alternative solutions or features you've considered. + ## Additional context -Add any other context about the feature request here. + diff --git a/.github/PULL_REQUEST_TEMPLATE.md b/.github/PULL_REQUEST_TEMPLATE.md index 211df04a3..e910ffbc7 100644 --- a/.github/PULL_REQUEST_TEMPLATE.md +++ b/.github/PULL_REQUEST_TEMPLATE.md @@ -1,3 +1,4 @@ + + ## PR checklist - [ ] This comment contains a description of changes (with reason) +- [ ] `CHANGELOG.md` is updated - [ ] If you've fixed a bug or added code that should be tested, add tests! -- [ ] If necessary, also make a PR on the [nf-core/chipseq branch on the nf-core/test-datasets repo](https://github.com/nf-core/test-datasets/pull/new/nf-core/chipseq) -- [ ] Ensure the test suite passes (`nextflow run . -profile test,docker`). -- [ ] Make sure your code lints (`nf-core lint .`). - [ ] Documentation in `docs` is updated -- [ ] `CHANGELOG.md` is updated -- [ ] `README.md` is updated - -**Learn more about contributing:** [CONTRIBUTING.md](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) \ No newline at end of file +- [ ] If necessary, also make a PR on the [nf-core/chipseq branch on the nf-core/test-datasets repo](https://github.com/nf-core/test-datasets/pull/new/nf-core/chipseq) diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml new file mode 100644 index 000000000..b6305e000 --- /dev/null +++ b/.github/workflows/awsfulltest.yml @@ -0,0 +1,40 @@ +name: nf-core AWS full size tests +# This workflow is triggered on push to the master branch. +# It runs the -profile 'test_full' on AWS batch + +on: + release: + types: [published] + +jobs: + run-awstest: + name: Run AWS full tests + if: github.repository == 'nf-core/chipseq' + runs-on: ubuntu-latest + steps: + - name: Setup Miniconda + uses: goanpeca/setup-miniconda@v1.0.2 + with: + auto-update-conda: true + python-version: 3.7 + - name: Install awscli + run: conda install -c conda-forge awscli + - name: Start AWS batch job + # TODO nf-core: You can customise AWS full pipeline tests as required + # Add full size test data (but still relatively small datasets for few samples) + # on the `test_full.config` test runs with only one set of parameters + # Then specify `-profile test_full` instead of `-profile test` on the AWS batch command + env: + AWS_ACCESS_KEY_ID: ${{ secrets.AWS_ACCESS_KEY_ID }} + AWS_SECRET_ACCESS_KEY: ${{ secrets.AWS_SECRET_ACCESS_KEY }} + TOWER_ACCESS_TOKEN: ${{ secrets.AWS_TOWER_TOKEN }} + AWS_JOB_DEFINITION: ${{ secrets.AWS_JOB_DEFINITION }} + AWS_JOB_QUEUE: ${{ secrets.AWS_JOB_QUEUE }} + AWS_S3_BUCKET: ${{ secrets.AWS_S3_BUCKET }} + run: | + aws batch submit-job \ + --region eu-west-1 \ + --job-name nf-core-chipseq \ + --job-queue $AWS_JOB_QUEUE \ + --job-definition $AWS_JOB_DEFINITION \ + --container-overrides '{"command": ["nf-core/chipseq", "-r '"${GITHUB_SHA}"' -profile test --outdir s3://'"${AWS_S3_BUCKET}"'/chipseq/results-'"${GITHUB_SHA}"' -w s3://'"${AWS_S3_BUCKET}"'/chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}' diff --git a/.github/workflows/awstest.yml b/.github/workflows/awstest.yml new file mode 100644 index 000000000..5da17324e --- /dev/null +++ b/.github/workflows/awstest.yml @@ -0,0 +1,40 @@ +name: nf-core AWS test +# This workflow is triggered on push to the master branch. +# It runs the -profile 'test' on AWS batch + +on: + push: + branches: + - master + +jobs: + run-awstest: + name: Run AWS tests + if: github.repository == 'nf-core/chipseq' + runs-on: ubuntu-latest + steps: + - name: Setup Miniconda + uses: goanpeca/setup-miniconda@v1.0.2 + with: + auto-update-conda: true + python-version: 3.7 + - name: Install awscli + run: conda install -c conda-forge awscli + - name: Start AWS batch job + # TODO nf-core: You can customise CI pipeline run tests as required + # For example: adding multiple test runs with different parameters + # Remember that you can parallelise this by using strategy.matrix + env: + AWS_ACCESS_KEY_ID: ${{ secrets.AWS_ACCESS_KEY_ID }} + AWS_SECRET_ACCESS_KEY: ${{ secrets.AWS_SECRET_ACCESS_KEY }} + TOWER_ACCESS_TOKEN: ${{ secrets.AWS_TOWER_TOKEN }} + AWS_JOB_DEFINITION: ${{ secrets.AWS_JOB_DEFINITION }} + AWS_JOB_QUEUE: ${{ secrets.AWS_JOB_QUEUE }} + AWS_S3_BUCKET: ${{ secrets.AWS_S3_BUCKET }} + run: | + aws batch submit-job \ + --region eu-west-1 \ + --job-name nf-core-chipseq \ + --job-queue $AWS_JOB_QUEUE \ + --job-definition $AWS_JOB_DEFINITION \ + --container-overrides '{"command": ["nf-core/chipseq", "-r '"${GITHUB_SHA}"' -profile test --outdir s3://'"${AWS_S3_BUCKET}"'/chipseq/results-'"${GITHUB_SHA}"' -w s3://'"${AWS_S3_BUCKET}"'/chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}'chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}' diff --git a/.github/workflows/branch.yml b/.github/workflows/branch.yml index aa94952dc..492b3ab3d 100644 --- a/.github/workflows/branch.yml +++ b/.github/workflows/branch.yml @@ -3,14 +3,34 @@ name: nf-core branch protection # It fails when someone tries to make a PR against the nf-core `master` branch instead of `dev` on: pull_request: - branches: - - master + branches: [master] jobs: test: - runs-on: ubuntu-18.04 + runs-on: ubuntu-latest steps: - # PRs are only ok if coming from an nf-core `dev` branch or a fork `patch` branch + # PRs to the nf-core repo master branch are only ok if coming from the nf-core repo `dev` or any `patch` branches - name: Check PRs + if: github.repository == 'nf-core/chipseq' run: | - { [[ $(git remote get-url origin) == *nf-core/chipseq ]] && [[ ${GITHUB_HEAD_REF} = "dev" ]]; } || [[ ${GITHUB_HEAD_REF} == "patch" ]] + { [[ ${{github.event.pull_request.head.repo.full_name}} == nf-core/chipseq ]] && [[ $GITHUB_HEAD_REF = "dev" ]]; } || [[ $GITHUB_HEAD_REF == "patch" ]] + + + # If the above check failed, post a comment on the PR explaining the failure + - name: Post PR comment + if: failure() + uses: mshick/add-pr-comment@v1 + with: + message: | + Hi @${{ github.event.pull_request.user.login }}, + + It looks like this pull-request is has been made against the ${{github.event.pull_request.head.repo.full_name}} `master` branch. + The `master` branch on nf-core repositories should always contain code from the latest release. + Because of this, PRs to `master` are only allowed if they come from the ${{github.event.pull_request.head.repo.full_name}} `dev` branch. + + You do not need to close this PR, you can change the target branch to `dev` by clicking the _"Edit"_ button at the top of this page. + + Thanks again for your contribution! + repo-token: ${{ secrets.GITHUB_TOKEN }} + allow-repeats: false + diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 7062197c0..14df9f1d0 100644 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -1,30 +1,55 @@ name: nf-core CI -# This workflow is triggered on pushes and PRs to the repository. -# It runs the pipeline with the minimal test dataset to check that it completes without any syntax errors -on: [push, pull_request] +# This workflow runs the pipeline with the minimal test dataset to check that it completes without any syntax errors +on: + push: + branches: + - dev + pull_request: + release: + types: [published] jobs: test: + name: Run workflow tests + # Only run on push if this is the nf-core dev branch (merged PRs) + if: ${{ github.event_name != 'push' || (github.event_name == 'push' && github.repository == 'nf-core/chipseq') }} + runs-on: ubuntu-latest env: NXF_VER: ${{ matrix.nxf_ver }} NXF_ANSI_LOG: false - runs-on: ubuntu-latest strategy: matrix: # Nextflow versions: check pipeline minimum and current latest nxf_ver: ['19.10.0', ''] steps: - - uses: actions/checkout@v2 - - name: Install Nextflow - run: | - wget -qO- get.nextflow.io | bash - sudo mv nextflow /usr/local/bin/ + - name: Check out pipeline code + uses: actions/checkout@v2 + + - name: Check if Dockerfile or Conda environment changed + uses: technote-space/get-diff-action@v1 + with: + PREFIX_FILTER: | + Dockerfile + environment.yml + + - name: Build new docker image + if: env.GIT_DIFF + run: docker build --no-cache . -t nfcore/chipseq:dev + - name: Pull docker image + if: ${{ !env.GIT_DIFF }} run: | docker pull nfcore/chipseq:dev docker tag nfcore/chipseq:dev nfcore/chipseq:dev + + - name: Install Nextflow + run: | + wget -qO- get.nextflow.io | bash + sudo mv nextflow /usr/local/bin/ + - name: Run pipeline with test data + # TODO nf-core: You can customise CI pipeline run tests as required + # For example: adding multiple test runs with different parameters + # Remember that you can parallelise this by using strategy.matrix run: | - # TODO nf-core: You can customise CI pipeline run tests as required - # (eg. adding multiple test runs with different parameters) nextflow run ${GITHUB_WORKSPACE} -profile test,docker diff --git a/.github/workflows/linting.yml b/.github/workflows/linting.yml index 1e0827a80..eb66c1449 100644 --- a/.github/workflows/linting.yml +++ b/.github/workflows/linting.yml @@ -33,18 +33,29 @@ jobs: nf-core: runs-on: ubuntu-latest steps: - - uses: actions/checkout@v2 + + - name: Check out pipeline code + uses: actions/checkout@v2 + - name: Install Nextflow run: | wget -qO- get.nextflow.io | bash sudo mv nextflow /usr/local/bin/ + - uses: actions/setup-python@v1 with: python-version: '3.6' architecture: 'x64' + - name: Install dependencies run: | python -m pip install --upgrade pip pip install nf-core + - name: Run nf-core lint + env: + GITHUB_COMMENTS_URL: ${{ github.event.pull_request.comments_url }} + GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }} + GITHUB_PR_COMMIT: ${{ github.event.pull_request.head.sha }} run: nf-core lint ${GITHUB_WORKSPACE} + diff --git a/.github/workflows/push_dockerhub.yml b/.github/workflows/push_dockerhub.yml new file mode 100644 index 000000000..96d7636c9 --- /dev/null +++ b/.github/workflows/push_dockerhub.yml @@ -0,0 +1,39 @@ +name: nf-core Docker push +# This builds the docker image and pushes it to DockerHub +# Runs on nf-core repo releases and push event to 'dev' branch (PR merges) +on: + push: + branches: + - dev + release: + types: [published] + +push_dockerhub: + name: Push new Docker image to Docker Hub + runs-on: ubuntu-latest + # Only run for the nf-core repo, for releases and merged PRs + if: ${{ github.repository == 'nf-core/chipseq' }} + env: + DOCKERHUB_USERNAME: ${{ secrets.DOCKERHUB_USERNAME }} + DOCKERHUB_PASS: ${{ secrets.DOCKERHUB_PASS }} + steps: + - name: Check out pipeline code + uses: actions/checkout@v2 + + - name: Build new docker image + run: docker build --no-cache . -t nfcore/chipseq:latest + + - name: Push Docker image to DockerHub (dev) + if: ${{ github.event_name == 'push' }} + run: | + echo "$DOCKERHUB_PASS" | docker login -u "$DOCKERHUB_USERNAME" --password-stdin + docker tag nfcore/chipseq:latest nfcore/chipseq:dev + docker push nfcore/chipseq:dev + + - name: Push Docker image to DockerHub (release) + if: ${{ github.event_name == 'release' }} + run: | + echo "$DOCKERHUB_PASS" | docker login -u "$DOCKERHUB_USERNAME" --password-stdin + docker push nfcore/chipseq:latest + docker tag nfcore/chipseq:latest nfcore/chipseq:${{ github.event.release.tag_name }} + docker push nfcore/chipseq:${{ github.event.release.tag_name }} diff --git a/.gitignore b/.gitignore index 6354f3708..aa4bb5b37 100644 --- a/.gitignore +++ b/.gitignore @@ -5,4 +5,5 @@ results/ .DS_Store tests/ testing/ +testing* *.pyc diff --git a/CHANGELOG.md b/CHANGELOG.md index 9bf14bf1e..bcbe42c1b 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -1,11 +1,11 @@ # nf-core/chipseq: Changelog -The format is based on [Keep a Changelog](http://keepachangelog.com/en/1.0.0/) -and this project adheres to [Semantic Versioning](http://semver.org/spec/v2.0.0.html). +The format is based on [Keep a Changelog](https://keepachangelog.com/en/1.0.0/) +and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.html). -## v1.1.1dev - [date] +## v1.3.0dev - [date] -Initial release of nf-core/chipseq, created with the [nf-core](http://nf-co.re/) template. +Initial release of nf-core/chipseq, created with the [nf-core](https://nf-co.re/) template. ### `Added` diff --git a/CODE_OF_CONDUCT.md b/CODE_OF_CONDUCT.md index cf930c8ac..405fb1bfd 100644 --- a/CODE_OF_CONDUCT.md +++ b/CODE_OF_CONDUCT.md @@ -40,7 +40,7 @@ Project maintainers who do not follow or enforce the Code of Conduct in good fai ## Attribution -This Code of Conduct is adapted from the [Contributor Covenant][homepage], version 1.4, available at [http://contributor-covenant.org/version/1/4][version] +This Code of Conduct is adapted from the [Contributor Covenant][homepage], version 1.4, available at [https://www.contributor-covenant.org/version/1/4/code-of-conduct/][version] -[homepage]: http://contributor-covenant.org -[version]: http://contributor-covenant.org/version/1/4/ +[homepage]: https://contributor-covenant.org +[version]: https://www.contributor-covenant.org/version/1/4/code-of-conduct/ diff --git a/Dockerfile b/Dockerfile index 8bb131de1..0e2e359d6 100644 --- a/Dockerfile +++ b/Dockerfile @@ -1,13 +1,17 @@ -FROM nfcore/base:1.9 +FROM nfcore/base:1.10.1 LABEL authors="Philip Ewels" \ description="Docker image containing all software requirements for the nf-core/chipseq pipeline" # Install the conda environment COPY environment.yml / -RUN conda env create -f /environment.yml && conda clean -a +RUN conda env create --quiet -f /environment.yml && conda clean -a # Add conda installation dir to PATH (instead of doing 'conda activate') -ENV PATH /opt/conda/envs/nf-core-chipseq-1.1.1dev/bin:$PATH +ENV PATH /opt/conda/envs/nf-core-chipseq-1.3.0dev/bin:$PATH # Dump the details of the installed packages to a file for posterity -RUN conda env export --name nf-core-chipseq-1.1.1dev > nf-core-chipseq-1.1.1dev.yml +RUN conda env export --name nf-core-chipseq-1.3.0dev > nf-core-chipseq-1.3.0dev.yml + +# Instruct R processes to use these empty files instead of clashing with a local version +RUN touch .Rprofile +RUN touch .Renviron diff --git a/README.md b/README.md index b718ec207..256076543 100644 --- a/README.md +++ b/README.md @@ -6,8 +6,9 @@ [![GitHub Actions Linting Status](https://github.com/nf-core/chipseq/workflows/nf-core%20linting/badge.svg)](https://github.com/nf-core/chipseq/actions) [![Nextflow](https://img.shields.io/badge/nextflow-%E2%89%A519.10.0-brightgreen.svg)](https://www.nextflow.io/) -[![install with bioconda](https://img.shields.io/badge/install%20with-bioconda-brightgreen.svg)](http://bioconda.github.io/) +[![install with bioconda](https://img.shields.io/badge/install%20with-bioconda-brightgreen.svg)](https://bioconda.github.io/) [![Docker](https://img.shields.io/docker/automated/nfcore/chipseq.svg)](https://hub.docker.com/r/nfcore/chipseq) +[![Get help on Slack](http://img.shields.io/badge/slack-nf--core%20%23chipseq-4A154B?logo=slack)](https://nfcore.slack.com/channels/chipseq) ## Introduction @@ -15,40 +16,31 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool ## Quick Start -i. Install [`nextflow`](https://nf-co.re/usage/installation) +1. Install [`nextflow`](https://nf-co.re/usage/installation) -ii. Install either [`Docker`](https://docs.docker.com/engine/installation/) or [`Singularity`](https://www.sylabs.io/guides/3.0/user-guide/) for full pipeline reproducibility (please only use [`Conda`](https://conda.io/miniconda.html) as a last resort; see [docs](https://nf-co.re/usage/configuration#basic-configuration-profiles)) +2. Install either [`Docker`](https://docs.docker.com/engine/installation/) or [`Singularity`](https://www.sylabs.io/guides/3.0/user-guide/) for full pipeline reproducibility _(please only use [`Conda`](https://conda.io/miniconda.html) as a last resort; see [docs](https://nf-co.re/usage/configuration#basic-configuration-profiles))_ -iii. Download the pipeline and test it on a minimal dataset with a single command +3. Download the pipeline and test it on a minimal dataset with a single command: -```bash -nextflow run nf-core/chipseq -profile test, -``` + ```bash + nextflow run nf-core/chipseq -profile test, + ``` -> Please check [nf-core/configs](https://github.com/nf-core/configs#documentation) to see if a custom config file to run nf-core pipelines already exists for your Institute. If so, you can simply use `-profile ` in your command. This will enable either `docker` or `singularity` and set the appropriate execution settings for your local compute environment. + > Please check [nf-core/configs](https://github.com/nf-core/configs#documentation) to see if a custom config file to run nf-core pipelines already exists for your Institute. If so, you can simply use `-profile ` in your command. This will enable either `docker` or `singularity` and set the appropriate execution settings for your local compute environment. -iv. Start running your own analysis! +4. Start running your own analysis! - + -```bash -nextflow run nf-core/chipseq -profile --reads '*_R{1,2}.fastq.gz' --genome GRCh37 -``` + ```bash + nextflow run nf-core/chipseq -profile --input '*_R{1,2}.fastq.gz' --genome GRCh37 + ``` See [usage docs](docs/usage.md) for all of the available options when running the pipeline. ## Documentation -The nf-core/chipseq pipeline comes with documentation about the pipeline, found in the `docs/` directory: - -1. [Installation](https://nf-co.re/usage/installation) -2. Pipeline configuration - * [Local installation](https://nf-co.re/usage/local_installation) - * [Adding your own system config](https://nf-co.re/usage/adding_own_config) - * [Reference genomes](https://nf-co.re/usage/reference_genomes) -3. [Running the pipeline](docs/usage.md) -4. [Output and how to interpret the results](docs/output.md) -5. [Troubleshooting](https://nf-co.re/usage/troubleshooting) +The nf-core/chipseq pipeline comes with documentation about the pipeline which you can read at [https://nf-core/chipseq/docs](https://nf-core/chipseq/docs) or find in the [`docs/` directory](docs). @@ -60,7 +52,7 @@ nf-core/chipseq was originally written by Philip Ewels. If you would like to contribute to this pipeline, please see the [contributing guidelines](.github/CONTRIBUTING.md). -For further information or help, don't hesitate to get in touch on [Slack](https://nfcore.slack.com/channels/chipseq) (you can join with [this invite](https://nf-co.re/join/slack)). +For further information or help, don't hesitate to get in touch on the [Slack `#chipseq` channel](https://nfcore.slack.com/channels/chipseq) (you can join with [this invite](https://nf-co.re/join/slack)). ## Citation @@ -73,5 +65,5 @@ You can cite the `nf-core` publication as follows: > > Philip Ewels, Alexander Peltzer, Sven Fillinger, Harshil Patel, Johannes Alneberg, Andreas Wilm, Maxime Ulysse Garcia, Paolo Di Tommaso & Sven Nahnsen. > -> _Nat Biotechnol._ 2020 Feb 13. doi: [10.1038/s41587-020-0439-x](https://dx.doi.org/10.1038/s41587-020-0439-x). +> _Nat Biotechnol._ 2020 Feb 13. doi: [10.1038/s41587-020-0439-x](https://dx.doi.org/10.1038/s41587-020-0439-x). > ReadCube: [Full Access Link](https://rdcu.be/b1GjZ) diff --git a/bin/markdown_to_html.py b/bin/markdown_to_html.py index 57cc4263f..a26d1ff5e 100755 --- a/bin/markdown_to_html.py +++ b/bin/markdown_to_html.py @@ -4,33 +4,23 @@ import markdown import os import sys +import io + def convert_markdown(in_fn): - input_md = open(in_fn, mode="r", encoding="utf-8").read() + input_md = io.open(in_fn, mode="r", encoding="utf-8").read() html = markdown.markdown( "[TOC]\n" + input_md, - extensions = [ - 'pymdownx.extra', - 'pymdownx.b64', - 'pymdownx.highlight', - 'pymdownx.emoji', - 'pymdownx.tilde', - 'toc' - ], - extension_configs = { - 'pymdownx.b64': { - 'base_path': os.path.dirname(in_fn) - }, - 'pymdownx.highlight': { - 'noclasses': True - }, - 'toc': { - 'title': 'Table of Contents' - } - } + extensions=["pymdownx.extra", "pymdownx.b64", "pymdownx.highlight", "pymdownx.emoji", "pymdownx.tilde", "toc"], + extension_configs={ + "pymdownx.b64": {"base_path": os.path.dirname(in_fn)}, + "pymdownx.highlight": {"noclasses": True}, + "toc": {"title": "Table of Contents"}, + }, ) return html + def wrap_html(contents): header = """ @@ -83,18 +73,19 @@ def wrap_html(contents): def parse_args(args=None): parser = argparse.ArgumentParser() - parser.add_argument('mdfile', type=argparse.FileType('r'), nargs='?', - help='File to convert. Defaults to stdin.') - parser.add_argument('-o', '--out', type=argparse.FileType('w'), - default=sys.stdout, - help='Output file name. Defaults to stdout.') + parser.add_argument("mdfile", type=argparse.FileType("r"), nargs="?", help="File to convert. Defaults to stdin.") + parser.add_argument( + "-o", "--out", type=argparse.FileType("w"), default=sys.stdout, help="Output file name. Defaults to stdout." + ) return parser.parse_args(args) + def main(args=None): args = parse_args(args) converted_md = convert_markdown(args.mdfile.name) html = wrap_html(converted_md) args.out.write(html) -if __name__ == '__main__': + +if __name__ == "__main__": sys.exit(main()) diff --git a/bin/scrape_software_versions.py b/bin/scrape_software_versions.py index ba617e63c..f2d0a5cf2 100755 --- a/bin/scrape_software_versions.py +++ b/bin/scrape_software_versions.py @@ -5,16 +5,16 @@ # TODO nf-core: Add additional regexes for new tools in process get_software_versions regexes = { - 'nf-core/chipseq': ['v_pipeline.txt', r"(\S+)"], - 'Nextflow': ['v_nextflow.txt', r"(\S+)"], - 'FastQC': ['v_fastqc.txt', r"FastQC v(\S+)"], - 'MultiQC': ['v_multiqc.txt', r"multiqc, version (\S+)"], + "nf-core/chipseq": ["v_pipeline.txt", r"(\S+)"], + "Nextflow": ["v_nextflow.txt", r"(\S+)"], + "FastQC": ["v_fastqc.txt", r"FastQC v(\S+)"], + "MultiQC": ["v_multiqc.txt", r"multiqc, version (\S+)"], } results = OrderedDict() -results['nf-core/chipseq'] = 'N/A' -results['Nextflow'] = 'N/A' -results['FastQC'] = 'N/A' -results['MultiQC'] = 'N/A' +results["nf-core/chipseq"] = 'N/A' +results["Nextflow"] = 'N/A' +results["FastQC"] = 'N/A' +results["MultiQC"] = 'N/A' # Search each file using its regex for k, v in regexes.items(): @@ -30,10 +30,11 @@ # Remove software set to false in results for k in list(results): if not results[k]: - del(results[k]) + del results[k] # Dump to YAML -print (''' +print( + """ id: 'software_versions' section_name: 'nf-core/chipseq Software Versions' section_href: 'https://github.com/nf-core/chipseq' @@ -41,12 +42,13 @@ description: 'are collected at run time from the software output.' data: |
-''') -for k,v in results.items(): - print("
{}
{}
".format(k,v)) -print ("
") +""" +) +for k, v in results.items(): + print("
{}
{}
".format(k, v)) +print(" ") # Write out regexes as csv file: -with open('software_versions.csv', 'w') as f: - for k,v in results.items(): - f.write("{}\t{}\n".format(k,v)) +with open("software_versions.csv", "w") as f: + for k, v in results.items(): + f.write("{}\t{}\n".format(k, v)) diff --git a/conf/igenomes.config b/conf/igenomes.config index 2de924228..caeafceb2 100644 --- a/conf/igenomes.config +++ b/conf/igenomes.config @@ -340,6 +340,7 @@ params { gtf = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.bed" mito_name = "chrM" + macs_gsize = "1.37e9" } 'dm6' { fasta = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/WholeGenomeFasta/genome.fa" diff --git a/conf/test.config b/conf/test.config index 1cb87e03e..a0004e3ff 100644 --- a/conf/test.config +++ b/conf/test.config @@ -19,7 +19,7 @@ params { // TODO nf-core: Specify the paths to your test data on nf-core/test-datasets // TODO nf-core: Give any required params for the test so that command line flags are not needed single_end = false - readPaths = [ + input_paths = [ ['Testdata', ['https://github.com/nf-core/test-datasets/raw/exoseq/testdata/Testdata_R1.tiny.fastq.gz', 'https://github.com/nf-core/test-datasets/raw/exoseq/testdata/Testdata_R2.tiny.fastq.gz']], ['SRR389222', ['https://github.com/nf-core/test-datasets/raw/methylseq/testdata/SRR389222_sub1.fastq.gz', 'https://github.com/nf-core/test-datasets/raw/methylseq/testdata/SRR389222_sub2.fastq.gz']] ] diff --git a/conf/test_full.config b/conf/test_full.config new file mode 100644 index 000000000..deedc3a34 --- /dev/null +++ b/conf/test_full.config @@ -0,0 +1,22 @@ +/* + * ------------------------------------------------- + * Nextflow config file for running full-size tests + * ------------------------------------------------- + * Defines bundled input files and everything required + * to run a full size pipeline test. Use as follows: + * nextflow run nf-core/chipseq -profile test_full, + */ + +params { + config_profile_name = 'Full test profile' + config_profile_description = 'Full test dataset to check pipeline function' + + // Input data for full size test + // TODO nf-core: Specify the paths to your full test data ( on nf-core/test-datasets or directly in repositories, e.g. SRA) + // TODO nf-core: Give any required params for the test so that command line flags are not needed + single_end = false + readPaths = [ + ['Testdata', ['https://github.com/nf-core/test-datasets/raw/exoseq/testdata/Testdata_R1.tiny.fastq.gz', 'https://github.com/nf-core/test-datasets/raw/exoseq/testdata/Testdata_R2.tiny.fastq.gz']], + ['SRR389222', ['https://github.com/nf-core/test-datasets/raw/methylseq/testdata/SRR389222_sub1.fastq.gz', 'https://github.com/nf-core/test-datasets/raw/methylseq/testdata/SRR389222_sub2.fastq.gz']] + ] +} diff --git a/docs/README.md b/docs/README.md index 80d36de34..84fa58441 100644 --- a/docs/README.md +++ b/docs/README.md @@ -1,12 +1,12 @@ # nf-core/chipseq: Documentation -The nf-core/chipseq documentation is split into the following files: - -1. [Installation](https://nf-co.re/usage/installation) -2. Pipeline configuration - * [Local installation](https://nf-co.re/usage/local_installation) - * [Adding your own system config](https://nf-co.re/usage/adding_own_config) - * [Reference genomes](https://nf-co.re/usage/reference_genomes) -3. [Running the pipeline](usage.md) -4. [Output and how to interpret the results](output.md) -5. [Troubleshooting](https://nf-co.re/usage/troubleshooting) +The nf-core/chipseq documentation is split into the following pages: + + + +* [Usage](usage.md) + * An overview of how the pipeline works, how to run it and a description of all of the different command-line flags. +* [Output](output.md) + * An overview of the different results produced by the pipeline and how to interpret them. + +You can find a lot more documentation about installing, configuring and running nf-core pipelines on the website: [https://nf-co.re](https://nf-co.re) diff --git a/docs/output.md b/docs/output.md index 2816b060a..0bed8064d 100644 --- a/docs/output.md +++ b/docs/output.md @@ -2,6 +2,8 @@ This document describes the output produced by the pipeline. Most of the plots are taken from the MultiQC report, which summarises results at the end of the pipeline. +The directories listed below will be created in the results directory after the pipeline has finished. All paths are relative to the top-level results directory. + ## Pipeline overview @@ -9,35 +11,47 @@ This document describes the output produced by the pipeline. Most of the plots a The pipeline is built using [Nextflow](https://www.nextflow.io/) and processes data using the following steps: -* [FastQC](#fastqc) - read quality control -* [MultiQC](#multiqc) - aggregate report, describing results of the whole pipeline +* [FastQC](#fastqc) - Read quality control +* [MultiQC](#multiqc) - Aggregate report describing results from the whole pipeline +* [Pipeline information](#pipeline-information) - Report metrics generated during the workflow execution ## FastQC -[FastQC](http://www.bioinformatics.babraham.ac.uk/projects/fastqc/) gives general quality metrics about your reads. It provides information about the quality score distribution across your reads, the per base sequence content (%T/A/G/C). You get information about adapter contamination and other overrepresented sequences. +[FastQC](http://www.bioinformatics.babraham.ac.uk/projects/fastqc/) gives general quality metrics about your sequenced reads. It provides information about the quality score distribution across your reads, per base sequence content (%A/T/G/C), adapter contamination and overrepresented sequences. -For further reading and documentation see the [FastQC help](http://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/). +For further reading and documentation see the [FastQC help pages](http://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/). -> **NB:** The FastQC plots displayed in the MultiQC report shows _untrimmed_ reads. They may contain adapter sequence and potentially regions with low quality. To see how your reads look after trimming, look at the FastQC reports in the `trim_galore` directory. +**Output files:** -**Output directory: `results/fastqc`** +* `fastqc/` + * `*_fastqc.html`: FastQC report containing quality metrics for your untrimmed raw fastq files. +* `fastqc/zips/` + * `*_fastqc.zip`: Zip archive containing the FastQC report, tab-delimited data file and plot images. -* `sample_fastqc.html` - * FastQC report, containing quality metrics for your untrimmed raw fastq files -* `zips/sample_fastqc.zip` - * zip file containing the FastQC report, tab-delimited data file and plot images +> **NB:** The FastQC plots displayed in the MultiQC report shows _untrimmed_ reads. They may contain adapter sequence and potentially regions with low quality. ## MultiQC -[MultiQC](http://multiqc.info) is a visualisation tool that generates a single HTML report summarising all samples in your project. Most of the pipeline QC results are visualised in the report and further statistics are available in within the report data directory. +[MultiQC](http://multiqc.info) is a visualization tool that generates a single HTML report summarizing all samples in your project. Most of the pipeline QC results are visualised in the report and further statistics are available in the report data directory. + +The pipeline has special steps which also allow the software versions to be reported in the MultiQC output for future traceability. + +For more information about how to use MultiQC reports, see [https://multiqc.info](https://multiqc.info). + +**Output files:** + +* `multiqc/` + * `multiqc_report.html`: a standalone HTML file that can be viewed in your web browser. + * `multiqc_data/`: directory containing parsed statistics from the different tools used in the pipeline. + * `multiqc_plots/`: directory containing static images from the report in various formats. -The pipeline has special steps which allow the software versions used to be reported in the MultiQC output for future traceability. +## Pipeline information -**Output directory: `results/multiqc`** +[Nextflow](https://www.nextflow.io/docs/latest/tracing.html) provides excellent functionality for generating various reports relevant to the running and execution of the pipeline. This will allow you to troubleshoot errors with the running of the pipeline, and also provide you with other information such as launch commands, run times and resource usage. -* `Project_multiqc_report.html` - * MultiQC report - a standalone HTML file that can be viewed in your web browser -* `Project_multiqc_data/` - * Directory containing parsed statistics from the different tools used in the pipeline +**Output files:** -For more information about how to use MultiQC reports, see [http://multiqc.info](http://multiqc.info) +* `pipeline_info/` + * Reports generated by Nextflow: `execution_report.html`, `execution_timeline.html`, `execution_trace.txt` and `pipeline_dag.dot`/`pipeline_dag.svg`. + * Reports generated by the pipeline: `pipeline_report.html`, `pipeline_report.txt` and `software_versions.csv`. + * Documentation for interpretation of results in HTML format: `results_description.html`. diff --git a/docs/usage.md b/docs/usage.md index 5433cf5e4..ba405e485 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -1,62 +1,15 @@ # nf-core/chipseq: Usage -## Table of contents - -* [Table of contents](#table-of-contents) -* [Introduction](#introduction) -* [Running the pipeline](#running-the-pipeline) - * [Updating the pipeline](#updating-the-pipeline) - * [Reproducibility](#reproducibility) -* [Main arguments](#main-arguments) - * [`-profile`](#-profile) - * [`--reads`](#--reads) - * [`--single_end`](#--single_end) -* [Reference genomes](#reference-genomes) - * [`--genome` (using iGenomes)](#--genome-using-igenomes) - * [`--fasta`](#--fasta) - * [`--igenomes_ignore`](#--igenomes_ignore) -* [Job resources](#job-resources) - * [Automatic resubmission](#automatic-resubmission) - * [Custom resource requests](#custom-resource-requests) -* [AWS Batch specific parameters](#aws-batch-specific-parameters) - * [`--awsqueue`](#--awsqueue) - * [`--awsregion`](#--awsregion) - * [`--awscli`](#--awscli) -* [Other command line parameters](#other-command-line-parameters) - * [`--outdir`](#--outdir) - * [`--email`](#--email) - * [`--email_on_fail`](#--email_on_fail) - * [`--max_multiqc_email_size`](#--max_multiqc_email_size) - * [`-name`](#-name) - * [`-resume`](#-resume) - * [`-c`](#-c) - * [`--custom_config_version`](#--custom_config_version) - * [`--custom_config_base`](#--custom_config_base) - * [`--max_memory`](#--max_memory) - * [`--max_time`](#--max_time) - * [`--max_cpus`](#--max_cpus) - * [`--plaintext_email`](#--plaintext_email) - * [`--monochrome_logs`](#--monochrome_logs) - * [`--multiqc_config`](#--multiqc_config) - ## Introduction -Nextflow handles job submissions on SLURM or other environments, and supervises running the jobs. Thus the Nextflow process must run until the pipeline is finished. We recommend that you put the process running in the background through `screen` / `tmux` or similar tool. Alternatively you can run nextflow within a cluster job submitted your job scheduler. - -It is recommended to limit the Nextflow Java virtual machines memory. We recommend adding the following line to your environment (typically in `~/.bashrc` or `~./bash_profile`): - -```bash -NXF_OPTS='-Xms1g -Xmx4g' -``` - - + ## Running the pipeline The typical command for running the pipeline is as follows: ```bash -nextflow run nf-core/chipseq --reads '*_R{1,2}.fastq.gz' -profile docker +nextflow run nf-core/chipseq --input '*_R{1,2}.fastq.gz' -profile docker ``` This will launch the pipeline with the `docker` configuration profile. See below for more information about profiles. @@ -86,7 +39,9 @@ First, go to the [nf-core/chipseq releases page](https://github.com/nf-core/chip This version number will be logged in reports when you run the pipeline, so that you'll know what you used when you look back in the future. -## Main arguments +## Core Nextflow arguments + +> **NB:** These options are part of Nextflow and use a _single_ hyphen (pipeline parameters use a double-hyphen). ### `-profile` @@ -104,11 +59,11 @@ They are loaded in sequence, so later profiles can overwrite earlier profiles. If `-profile` is not specified, the pipeline will run locally and expect all software to be installed and available on the `PATH`. This is _not_ recommended. * `docker` - * A generic configuration profile to be used with [Docker](http://docker.com/) - * Pulls software from dockerhub: [`nfcore/chipseq`](http://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Docker](https://docker.com/) + * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) * `singularity` - * A generic configuration profile to be used with [Singularity](http://singularity.lbl.gov/) - * Pulls software from DockerHub: [`nfcore/chipseq`](http://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Singularity](https://sylabs.io/docs/) + * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) * `conda` * Please only use Conda as a last resort i.e. when it's not possible to run the pipeline with Docker or Singularity. * A generic configuration profile to be used with [Conda](https://conda.io/docs/) @@ -117,215 +72,50 @@ If `-profile` is not specified, the pipeline will run locally and expect all sof * A profile with a complete configuration for automated testing * Includes links to test data so needs no other parameters - - -### `--reads` - -Use this to specify the location of your input FastQ files. For example: - -```bash ---reads 'path/to/data/sample_*_{1,2}.fastq' -``` - -Please note the following requirements: - -1. The path must be enclosed in quotes -2. The path must have at least one `*` wildcard character -3. When using the pipeline with paired end data, the path must use `{1,2}` notation to specify read pairs. - -If left unspecified, a default pattern is used: `data/*{1,2}.fastq.gz` - -### `--single_end` - -By default, the pipeline expects paired-end data. If you have single-end data, you need to specify `--single_end` on the command line when you launch the pipeline. A normal glob pattern, enclosed in quotation marks, can then be used for `--reads`. For example: - -```bash ---single_end --reads '*.fastq' -``` - -It is not possible to run a mixture of single-end and paired-end files in one run. - -## Reference genomes - -The pipeline config files come bundled with paths to the illumina iGenomes reference index files. If running with docker or AWS, the configuration is set up to use the [AWS-iGenomes](https://ewels.github.io/AWS-iGenomes/) resource. - -### `--genome` (using iGenomes) +### `-resume` -There are 31 different species supported in the iGenomes references. To run the pipeline, you must specify which to use with the `--genome` flag. +Specify this when restarting a pipeline. Nextflow will used cached results from any pipeline steps where the inputs are the same, continuing from where it got to previously. -You can find the keys to specify the genomes in the [iGenomes config file](../conf/igenomes.config). Common genomes that are supported are: +You can also supply a run name to resume a specific run: `-resume [run-name]`. Use the `nextflow log` command to show previous run names. -* Human - * `--genome GRCh37` -* Mouse - * `--genome GRCm38` -* _Drosophila_ - * `--genome BDGP6` -* _S. cerevisiae_ - * `--genome 'R64-1-1'` +### `-c` -> There are numerous others - check the config file for more. +Specify the path to a specific config file (this is a core NextFlow command). See the [nf-core website documentation](https://nf-co.re/usage/configuration) for more information. -Note that you can use the same configuration setup to save sets of reference files for your own use, even if they are not part of the iGenomes resource. See the [Nextflow documentation](https://www.nextflow.io/docs/latest/config.html) for instructions on where to save such a file. +#### Custom resource requests -The syntax for this reference configuration is as follows: +Each step in the pipeline has a default set of requirements for number of CPUs, memory and time. For most of the steps in the pipeline, if the job exits with an error code of `143` (exceeded requested resources) it will automatically resubmit with higher requests (2 x original, then 3 x original). If it still fails after three times then the pipeline is stopped. - +Whilst these default requirements will hopefully work for most people with most data, you may find that you want to customise the compute resources that the pipeline requests. You can do this by creating a custom config file. For example, to give the workflow process `star` 32GB of memory, you could use the following config: ```nextflow -params { - genomes { - 'GRCh37' { - fasta = '' // Used if no star index given - } - // Any number of additional genomes, key is used with --genome +process { + withName: star { + memory = 32.GB } } ``` - - -### `--fasta` - -If you prefer, you can specify the full path to your reference genome when you run the pipeline: - -```bash ---fasta '[path to Fasta reference]' -``` - -### `--igenomes_ignore` - -Do not load `igenomes.config` when running the pipeline. You may choose this option if you observe clashes between custom parameters and those supplied in `igenomes.config`. - -## Job resources - -### Automatic resubmission - -Each step in the pipeline has a default set of requirements for number of CPUs, memory and time. For most of the steps in the pipeline, if the job exits with an error code of `143` (exceeded requested resources) it will automatically resubmit with higher requests (2 x original, then 3 x original). If it still fails after three times then the pipeline is stopped. - -### Custom resource requests - -Wherever process-specific requirements are set in the pipeline, the default value can be changed by creating a custom config file. See the files hosted at [`nf-core/configs`](https://github.com/nf-core/configs/tree/master/conf) for examples. +See the main [Nextflow documentation](https://www.nextflow.io/docs/latest/config.html) for more information. If you are likely to be running `nf-core` pipelines regularly it may be a good idea to request that your custom config file is uploaded to the `nf-core/configs` git repository. Before you do this please can you test that the config file works with your pipeline of choice using the `-c` parameter (see definition below). You can then create a pull request to the `nf-core/configs` repository with the addition of your config file, associated documentation file (see examples in [`nf-core/configs/docs`](https://github.com/nf-core/configs/tree/master/docs)), and amending [`nfcore_custom.config`](https://github.com/nf-core/configs/blob/master/nfcore_custom.config) to include your custom profile. -If you have any questions or issues please send us a message on [Slack](https://nf-co.re/join/slack). - -## AWS Batch specific parameters - -Running the pipeline on AWS Batch requires a couple of specific parameters to be set according to your AWS Batch configuration. Please use [`-profile awsbatch`](https://github.com/nf-core/configs/blob/master/conf/awsbatch.config) and then specify all of the following parameters. - -### `--awsqueue` - -The JobQueue that you intend to use on AWS Batch. +If you have any questions or issues please send us a message on [Slack](https://nf-co.re/join/slack) on the [`#configs` channel](https://nfcore.slack.com/channels/configs). -### `--awsregion` +### Running in the background -The AWS region in which to run your job. Default is set to `eu-west-1` but can be adjusted to your needs. +Nextflow handles job submissions and supervises the running jobs. The Nextflow process must run until the pipeline is finished. -### `--awscli` +The Nextflow `-bg` flag launches Nextflow in the background, detached from your terminal so that the workflow does not stop if you log out of your session. The logs are saved to a file. -The [AWS CLI](https://www.nextflow.io/docs/latest/awscloud.html#aws-cli-installation) path in your custom AMI. Default: `/home/ec2-user/miniconda/bin/aws`. +Alternatively, you can use `screen` / `tmux` or similar tool to create a detached session which you can log back into at a later time. +Some HPC setups also allow you to run nextflow within a cluster job submitted your job scheduler (from where it submits more jobs). -Please make sure to also set the `-w/--work-dir` and `--outdir` parameters to a S3 storage bucket of your choice - you'll get an error message notifying you if you didn't. +#### Nextflow memory requirements -## Other command line parameters - - - -### `--outdir` - -The output directory where the results will be saved. - -### `--email` - -Set this parameter to your e-mail address to get a summary e-mail with details of the run sent to you when the workflow exits. If set in your user config file (`~/.nextflow/config`) then you don't need to specify this on the command line for every run. - -### `--email_on_fail` - -This works exactly as with `--email`, except emails are only sent if the workflow is not successful. - -### `--max_multiqc_email_size` - -Threshold size for MultiQC report to be attached in notification email. If file generated by pipeline exceeds the threshold, it will not be attached (Default: 25MB). - -### `-name` - -Name for the pipeline run. If not specified, Nextflow will automatically generate a random mnemonic. - -This is used in the MultiQC report (if not default) and in the summary HTML / e-mail (always). - -**NB:** Single hyphen (core Nextflow option) - -### `-resume` - -Specify this when restarting a pipeline. Nextflow will used cached results from any pipeline steps where the inputs are the same, continuing from where it got to previously. - -You can also supply a run name to resume a specific run: `-resume [run-name]`. Use the `nextflow log` command to show previous run names. - -**NB:** Single hyphen (core Nextflow option) - -### `-c` - -Specify the path to a specific config file (this is a core NextFlow command). - -**NB:** Single hyphen (core Nextflow option) - -Note - you can use this to override pipeline defaults. - -### `--custom_config_version` - -Provide git commit id for custom Institutional configs hosted at `nf-core/configs`. This was implemented for reproducibility purposes. Default: `master`. - -```bash -## Download and use config file with following git commid id ---custom_config_version d52db660777c4bf36546ddb188ec530c3ada1b96 -``` - -### `--custom_config_base` - -If you're running offline, nextflow will not be able to fetch the institutional config files -from the internet. If you don't need them, then this is not a problem. If you do need them, -you should download the files from the repo and tell nextflow where to find them with the -`custom_config_base` option. For example: +In some cases, the Nextflow Java virtual machines can start to request a large amount of memory. +We recommend adding the following line to your environment to limit this (typically in `~/.bashrc` or `~./bash_profile`): ```bash -## Download and unzip the config files -cd /path/to/my/configs -wget https://github.com/nf-core/configs/archive/master.zip -unzip master.zip - -## Run the pipeline -cd /path/to/my/data -nextflow run /path/to/pipeline/ --custom_config_base /path/to/my/configs/configs-master/ +NXF_OPTS='-Xms1g -Xmx4g' ``` - -> Note that the nf-core/tools helper package has a `download` command to download all required pipeline -> files + singularity containers + institutional configs in one go for you, to make this process easier. - -### `--max_memory` - -Use to set a top-limit for the default memory requirement for each process. -Should be a string in the format integer-unit. eg. `--max_memory '8.GB'` - -### `--max_time` - -Use to set a top-limit for the default time requirement for each process. -Should be a string in the format integer-unit. eg. `--max_time '2.h'` - -### `--max_cpus` - -Use to set a top-limit for the default CPU requirement for each process. -Should be a string in the format integer-unit. eg. `--max_cpus 1` - -### `--plaintext_email` - -Set to receive plain-text e-mails instead of HTML formatted. - -### `--monochrome_logs` - -Set to disable colourful command line output and live life in monochrome. - -### `--multiqc_config` - -Specify a path to a custom MultiQC configuration file. diff --git a/environment.yml b/environment.yml index a32b3b167..88677053e 100644 --- a/environment.yml +++ b/environment.yml @@ -1,6 +1,6 @@ # You can use this file to create a conda environment for this pipeline: # conda env create -f environment.yml -name: nf-core-chipseq-1.1.1dev +name: nf-core-chipseq-1.3.0dev channels: - conda-forge - bioconda diff --git a/main.nf b/main.nf index ac5a1cfba..15a4dfcce 100644 --- a/main.nf +++ b/main.nf @@ -18,12 +18,12 @@ def helpMessage() { The typical command for running the pipeline is as follows: - nextflow run nf-core/chipseq --reads '*_R{1,2}.fastq.gz' -profile docker + nextflow run nf-core/chipseq --input '*_R{1,2}.fastq.gz' -profile docker Mandatory arguments: - --reads [file] Path to input data (must be surrounded with quotes) - -profile [str] Configuration profile to use. Can use multiple (comma separated) - Available: conda, docker, singularity, test, awsbatch, and more + --input [file] Path to input data (must be surrounded with quotes) + -profile [str] Configuration profile to use. Can use multiple (comma separated) + Available: conda, docker, singularity, test, awsbatch, and more Options: --genome [str] Name of iGenomes reference @@ -34,9 +34,10 @@ def helpMessage() { Other options: --outdir [file] The output directory where the results will be saved + --publish_dir_mode [str] Mode for publishing results in the output directory. Available: symlink, rellink, link, copy, copyNoFollow, move (Default: copy) --email [email] Set this parameter to your e-mail address to get a summary e-mail with details of the run sent to you when the workflow exits --email_on_fail [email] Same as --email, except only send mail if the workflow is not successful - --max_multiqc_email_size [str] Theshold size for MultiQC report to be attached in notification email. If file generated by pipeline exceeds the threshold, it will not be attached (Default: 25MB) + --max_multiqc_email_size [str] Threshold size for MultiQC report to be attached in notification email. If file generated by pipeline exceeds the threshold, it will not be attached (Default: 25MB) -name [str] Name for the pipeline run. If not specified, Nextflow will automatically generate a random mnemonic AWSBatch options: @@ -73,12 +74,13 @@ params.fasta = params.genome ? params.genomes[ params.genome ].fasta ?: false : if (params.fasta) { ch_fasta = file(params.fasta, checkIfExists: true) } // Has the run name been specified by the user? -// this has the bonus effect of catching both -name and --name +// this has the bonus effect of catching both -name and --name custom_runName = params.name if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { custom_runName = workflow.runName } +// Check AWS batch settings if (workflow.profile.contains('awsbatch')) { // AWSBatch sanity checking if (!params.awsqueue || !params.awsregion) exit 1, "Specify correct --awsqueue and --awsregion parameters on AWSBatch!" @@ -93,28 +95,29 @@ if (workflow.profile.contains('awsbatch')) { ch_multiqc_config = file("$baseDir/assets/multiqc_config.yaml", checkIfExists: true) ch_multiqc_custom_config = params.multiqc_config ? Channel.fromPath(params.multiqc_config, checkIfExists: true) : Channel.empty() ch_output_docs = file("$baseDir/docs/output.md", checkIfExists: true) +ch_output_docs_images = file("$baseDir/docs/images/", checkIfExists: true) /* * Create a channel for input read files */ -if (params.readPaths) { +if (params.input_paths) { if (params.single_end) { Channel - .from(params.readPaths) + .from(params.input_paths) .map { row -> [ row[0], [ file(row[1][0], checkIfExists: true) ] ] } - .ifEmpty { exit 1, "params.readPaths was empty - no input files supplied" } + .ifEmpty { exit 1, "params.input_paths was empty - no input files supplied" } .into { ch_read_files_fastqc; ch_read_files_trimming } } else { Channel - .from(params.readPaths) + .from(params.input_paths) .map { row -> [ row[0], [ file(row[1][0], checkIfExists: true), file(row[1][1], checkIfExists: true) ] ] } - .ifEmpty { exit 1, "params.readPaths was empty - no input files supplied" } + .ifEmpty { exit 1, "params.input_paths was empty - no input files supplied" } .into { ch_read_files_fastqc; ch_read_files_trimming } } } else { Channel - .fromFilePairs(params.reads, size: params.single_end ? 1 : 2) - .ifEmpty { exit 1, "Cannot find any reads matching: ${params.reads}\nNB: Path needs to be enclosed in quotes!\nIf this is single-end data, please specify --single_end on the command line." } + .fromFilePairs(params.input, size: params.single_end ? 1 : 2) + .ifEmpty { exit 1, "Cannot find any reads matching: ${params.input}\nNB: Path needs to be enclosed in quotes!\nIf this is single-end data, please specify --single_end on the command line." } .into { ch_read_files_fastqc; ch_read_files_trimming } } @@ -124,7 +127,7 @@ def summary = [:] if (workflow.revision) summary['Pipeline Release'] = workflow.revision summary['Run Name'] = custom_runName ?: workflow.runName // TODO nf-core: Report custom parameters here -summary['Reads'] = params.reads +summary['Reads'] = params.input summary['Fasta Ref'] = params.fasta summary['Data Type'] = params.single_end ? 'Single-End' : 'Paired-End' summary['Max Resources'] = "$params.max_memory memory, $params.max_cpus cpus, $params.max_time time per job" @@ -140,9 +143,10 @@ if (workflow.profile.contains('awsbatch')) { summary['AWS CLI'] = params.awscli } summary['Config Profile'] = workflow.profile -if (params.config_profile_description) summary['Config Description'] = params.config_profile_description -if (params.config_profile_contact) summary['Config Contact'] = params.config_profile_contact -if (params.config_profile_url) summary['Config URL'] = params.config_profile_url +if (params.config_profile_description) summary['Config Profile Description'] = params.config_profile_description +if (params.config_profile_contact) summary['Config Profile Contact'] = params.config_profile_contact +if (params.config_profile_url) summary['Config Profile URL'] = params.config_profile_url +summary['Config Files'] = workflow.configFiles.join(', ') if (params.email || params.email_on_fail) { summary['E-mail Address'] = params.email summary['E-mail on failure'] = params.email_on_fail @@ -174,7 +178,7 @@ Channel.from(summary.collect{ [it.key, it.value] }) * Parse software version numbers */ process get_software_versions { - publishDir "${params.outdir}/pipeline_info", mode: 'copy', + publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode, saveAs: { filename -> if (filename.indexOf(".csv") > 0) filename else null @@ -201,7 +205,7 @@ process get_software_versions { process fastqc { tag "$name" label 'process_medium' - publishDir "${params.outdir}/fastqc", mode: 'copy', + publishDir "${params.outdir}/fastqc", mode: params.publish_dir_mode, saveAs: { filename -> filename.indexOf(".zip") > 0 ? "zips/$filename" : "$filename" } @@ -222,7 +226,7 @@ process fastqc { * STEP 2 - MultiQC */ process multiqc { - publishDir "${params.outdir}/MultiQC", mode: 'copy' + publishDir "${params.outdir}/MultiQC", mode: params.publish_dir_mode input: file (multiqc_config) from ch_multiqc_config @@ -251,10 +255,11 @@ process multiqc { * STEP 3 - Output Description HTML */ process output_documentation { - publishDir "${params.outdir}/pipeline_info", mode: 'copy' + publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode input: file output_docs from ch_output_docs + file images from ch_output_docs_images output: file "results_description.html" @@ -345,7 +350,11 @@ workflow.onComplete { log.info "[nf-core/chipseq] Sent summary e-mail to $email_address (sendmail)" } catch (all) { // Catch failures and try with plaintext - [ 'mail', '-s', subject, email_address ].execute() << email_txt + def mail_cmd = [ 'mail', '-s', subject, '--content-type=text/html', email_address ] + if ( mqc_report.size() <= params.max_multiqc_email_size.toBytes() ) { + mail_cmd += [ '-A', mqc_report ] + } + mail_cmd.execute() << email_html log.info "[nf-core/chipseq] Sent summary e-mail to $email_address (mail)" } } diff --git a/nextflow.config b/nextflow.config index 1eadc7d5f..a547df3fc 100644 --- a/nextflow.config +++ b/nextflow.config @@ -11,9 +11,10 @@ params { // Workflow flags // TODO nf-core: Specify your pipeline's command line flags genome = false - reads = "data/*{1,2}.fastq.gz" + input = "data/*{1,2}.fastq.gz" single_end = false outdir = './results' + publish_dir_mode = 'copy' // Boilerplate options name = false @@ -78,9 +79,11 @@ if (!params.igenomes_ignore) { includeConfig 'conf/igenomes.config' } -// Export this variable to prevent local Python libraries from conflicting with those in the container +// Export these variables to prevent local Python/R libraries from conflicting with those in the container env { PYTHONNOUSERSITE = 1 + R_PROFILE_USER = "/.Rprofile" + R_ENVIRON_USER = "/.Renviron" } // Capture exit codes from upstream processes when piping @@ -110,7 +113,7 @@ manifest { description = 'ChIP-seq peak-calling and differential analysis pipeline.' mainScript = 'main.nf' nextflowVersion = '>=19.10.0' - version = '1.1.1dev' + version = '1.3.0dev' } // Function to ensure that resource requirements don't go beyond diff --git a/nextflow_schema.json b/nextflow_schema.json new file mode 100644 index 000000000..37e0fdf2e --- /dev/null +++ b/nextflow_schema.json @@ -0,0 +1,259 @@ +{ + "$schema": "https://json-schema.org/draft-07/schema", + "$id": "https://raw.githubusercontent.com/nf-core/chipseq/master/nextflow_schema.json", + "title": "nf-core/chipseq pipeline parameters", + "description": "ChIP-seq peak-calling and differential analysis pipeline.", + "type": "object", + "definitions": { + "input_output_options": { + "title": "Input/output options", + "type": "object", + "fa_icon": "fas fa-terminal", + "description": "Define where the pipeline should find input data and save output data.", + "required": [ + "input" + ], + "properties": { + "input": { + "type": "string", + "fa_icon": "fas fa-dna", + "description": "Input FastQ files.", + "help_text": "Use this to specify the location of your input FastQ files. For example:\n\n```bash\n--input 'path/to/data/sample_*_{1,2}.fastq'\n```\n\nPlease note the following requirements:\n\n1. The path must be enclosed in quotes\n2. The path must have at least one `*` wildcard character\n3. When using the pipeline with paired end data, the path must use `{1,2}` notation to specify read pairs.\n\nIf left unspecified, a default pattern is used: `data/*{1,2}.fastq.gz`" + }, + "single_end": { + "type": "boolean", + "description": "Specifies that the input is single-end reads.", + "fa_icon": "fas fa-align-center", + "help_text": "By default, the pipeline expects paired-end data. If you have single-end data, you need to specify `--single_end` on the command line when you launch the pipeline. A normal glob pattern, enclosed in quotation marks, can then be used for `--input`. For example:\n\n```bash\n--single_end --input '*.fastq'\n```\n\nIt is not possible to run a mixture of single-end and paired-end files in one run." + }, + "outdir": { + "type": "string", + "description": "The output directory where the results will be saved.", + "default": "./results", + "fa_icon": "fas fa-folder-open" + }, + "email": { + "type": "string", + "description": "Email address for completion summary.", + "fa_icon": "fas fa-envelope", + "help_text": "Set this parameter to your e-mail address to get a summary e-mail with details of the run sent to you when the workflow exits. If set in your user config file (`~/.nextflow/config`) then you don't need to specify this on the command line for every run.", + "pattern": "^([a-zA-Z0-9_\\-\\.]+)@([a-zA-Z0-9_\\-\\.]+)\\.([a-zA-Z]{2,5})$" + } + } + }, + "reference_genome_options": { + "title": "Reference genome options", + "type": "object", + "fa_icon": "fas fa-dna", + "description": "Options for the reference genome indices used to align reads.", + "properties": { + "genome": { + "type": "string", + "description": "Name of iGenomes reference.", + "fa_icon": "fas fa-book", + "help_text": "If using a reference genome configured in the pipeline using iGenomes, use this parameter to give the ID for the reference. This is then used to build the full paths for all required reference genome files e.g. `--genome GRCh38`.\n\nSee the [nf-core website docs](https://nf-co.re/usage/reference_genomes) for more details." + }, + "fasta": { + "type": "string", + "fa_icon": "fas fa-font", + "description": "Path to FASTA genome file.", + "help_text": "If you have no genome reference available, the pipeline can build one using a FASTA file. This requires additional time and resources, so it's better to use a pre-build index if possible." + }, + "igenomes_base": { + "type": "string", + "description": "Directory / URL base for iGenomes references.", + "default": "s3://ngi-igenomes/igenomes/", + "fa_icon": "fas fa-cloud-download-alt", + "hidden": true + }, + "igenomes_ignore": { + "type": "boolean", + "description": "Do not load the iGenomes reference config.", + "fa_icon": "fas fa-ban", + "hidden": true, + "help_text": "Do not load `igenomes.config` when running the pipeline. You may choose this option if you observe clashes between custom parameters and those supplied in `igenomes.config`." + } + } + }, + "generic_options": { + "title": "Generic options", + "type": "object", + "fa_icon": "fas fa-file-import", + "description": "Less common options for the pipeline, typically set in a config file.", + "help_text": "These options are common to all nf-core pipelines and allow you to customise some of the core preferences for how the pipeline runs.\n\nTypically these options would be set in a Nextflow config file loaded for all pipeline runs, such as `~/.nextflow/config`.", + "properties": { + "help": { + "type": "boolean", + "description": "Display help text.", + "hidden": true, + "fa_icon": "fas fa-question-circle" + }, + "publish_dir_mode": { + "type": "string", + "default": "copy", + "hidden": true, + "description": "Method used to save pipeline results to output directory.", + "help_text": "The Nextflow `publishDir` option specifies which intermediate files should be saved to the output directory. This option tells the pipeline what method should be used to move these files. See [Nextflow docs](https://www.nextflow.io/docs/latest/process.html#publishdir) for details.", + "fa_icon": "fas fa-copy", + "enum": [ + "symlink", + "rellink", + "link", + "copy", + "copyNoFollow", + "mov" + ] + }, + "name": { + "type": "string", + "description": "Workflow name.", + "fa_icon": "fas fa-fingerprint", + "hidden": true, + "help_text": "A custom name for the pipeline run. Unlike the core nextflow `-name` option with one hyphen this parameter can be reused multiple times, for example if using `-resume`. Passed through to steps such as MultiQC and used for things like report filenames and titles." + }, + "email_on_fail": { + "type": "string", + "description": "Email address for completion summary, only when pipeline fails.", + "fa_icon": "fas fa-exclamation-triangle", + "pattern": "^([a-zA-Z0-9_\\-\\.]+)@([a-zA-Z0-9_\\-\\.]+)\\.([a-zA-Z]{2,5})$", + "hidden": true, + "help_text": "This works exactly as with `--email`, except emails are only sent if the workflow is not successful." + }, + "plaintext_email": { + "type": "boolean", + "description": "Send plain-text email instead of HTML.", + "fa_icon": "fas fa-remove-format", + "hidden": true, + "help_text": "Set to receive plain-text e-mails instead of HTML formatted." + }, + "max_multiqc_email_size": { + "type": "string", + "description": "File size limit when attaching MultiQC reports to summary emails.", + "default": "25.MB", + "fa_icon": "fas fa-file-upload", + "hidden": true, + "help_text": "If file generated by pipeline exceeds the threshold, it will not be attached." + }, + "monochrome_logs": { + "type": "boolean", + "description": "Do not use coloured log outputs.", + "fa_icon": "fas fa-palette", + "hidden": true, + "help_text": "Set to disable colourful command line output and live life in monochrome." + }, + "multiqc_config": { + "type": "string", + "description": "Custom config file to supply to MultiQC.", + "fa_icon": "fas fa-cog", + "hidden": true + }, + "tracedir": { + "type": "string", + "description": "Directory to keep pipeline Nextflow logs and reports.", + "default": "${params.outdir}/pipeline_info", + "fa_icon": "fas fa-cogs", + "hidden": true + } + } + }, + "max_job_request_options": { + "title": "Max job request options", + "type": "object", + "fa_icon": "fab fa-acquisitions-incorporated", + "description": "Set the top limit for requested resources for any single job.", + "help_text": "If you are running on a smaller system, a pipeline step requesting more resources than are available may cause the Nextflow to stop the run with an error. These options allow you to cap the maximum resources requested by any single job so that the pipeline will run on your system.\n\nNote that you can not _increase_ the resources requested by any job using these options. For that you will need your own configuration file. See [the nf-core website](https://nf-co.re/usage/configuration) for details.", + "properties": { + "max_cpus": { + "type": "integer", + "description": "Maximum number of CPUs that can be requested for any single job.", + "default": 16, + "fa_icon": "fas fa-microchip", + "hidden": true, + "help_text": "Use to set an upper-limit for the CPU requirement for each process. Should be an integer e.g. `--max_cpus 1`" + }, + "max_memory": { + "type": "string", + "description": "Maximum amount of memory that can be requested for any single job.", + "default": "128.GB", + "fa_icon": "fas fa-memory", + "hidden": true, + "help_text": "Use to set an upper-limit for the memory requirement for each process. Should be a string in the format integer-unit e.g. `--max_memory '8.GB'`" + }, + "max_time": { + "type": "string", + "description": "Maximum amount of time that can be requested for any single job.", + "default": "240.h", + "fa_icon": "far fa-clock", + "hidden": true, + "help_text": "Use to set an upper-limit for the time requirement for each process. Should be a string in the format integer-unit e.g. `--max_time '2.h'`" + } + } + }, + "institutional_config_options": { + "title": "Institutional config options", + "type": "object", + "fa_icon": "fas fa-university", + "description": "Parameters used to describe centralised config profiles. These should not be edited.", + "help_text": "The centralised nf-core configuration profiles use a handful of pipeline parameters to describe themselves. This information is then printed to the Nextflow log when you run a pipeline. You should not need to change these values when you run a pipeline.", + "properties": { + "custom_config_version": { + "type": "string", + "description": "Git commit id for Institutional configs.", + "default": "master", + "hidden": true, + "fa_icon": "fas fa-users-cog", + "help_text": "Provide git commit id for custom Institutional configs hosted at `nf-core/configs`. This was implemented for reproducibility purposes. Default: `master`.\n\n```bash\n## Download and use config file with following git commit id\n--custom_config_version d52db660777c4bf36546ddb188ec530c3ada1b96\n```" + }, + "custom_config_base": { + "type": "string", + "description": "Base directory for Institutional configs.", + "default": "https://raw.githubusercontent.com/nf-core/configs/master", + "hidden": true, + "help_text": "If you're running offline, nextflow will not be able to fetch the institutional config files from the internet. If you don't need them, then this is not a problem. If you do need them, you should download the files from the repo and tell nextflow where to find them with the `custom_config_base` option. For example:\n\n```bash\n## Download and unzip the config files\ncd /path/to/my/configs\nwget https://github.com/nf-core/configs/archive/master.zip\nunzip master.zip\n\n## Run the pipeline\ncd /path/to/my/data\nnextflow run /path/to/pipeline/ --custom_config_base /path/to/my/configs/configs-master/\n```\n\n> Note that the nf-core/tools helper package has a `download` command to download all required pipeline files + singularity containers + institutional configs in one go for you, to make this process easier.", + "fa_icon": "fas fa-users-cog" + }, + "hostnames": { + "type": "string", + "description": "Institutional configs hostname.", + "hidden": true, + "fa_icon": "fas fa-users-cog" + }, + "config_profile_description": { + "type": "string", + "description": "Institutional config description.", + "hidden": true, + "fa_icon": "fas fa-users-cog" + }, + "config_profile_contact": { + "type": "string", + "description": "Institutional config contact information.", + "hidden": true, + "fa_icon": "fas fa-users-cog" + }, + "config_profile_url": { + "type": "string", + "description": "Institutional config URL link.", + "hidden": true, + "fa_icon": "fas fa-users-cog" + } + } + } + }, + "allOf": [ + { + "$ref": "#/definitions/input_output_options" + }, + { + "$ref": "#/definitions/reference_genome_options" + }, + { + "$ref": "#/definitions/generic_options" + }, + { + "$ref": "#/definitions/max_job_request_options" + }, + { + "$ref": "#/definitions/institutional_config_options" + } + ] +} From b13fda88b1a05027cde5696cfbf7a115ed6ec830 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Thu, 30 Jul 2020 21:57:40 +0100 Subject: [PATCH 099/538] Dummy commit --- main.nf | 1 + 1 file changed, 1 insertion(+) diff --git a/main.nf b/main.nf index 4497bf105..75f59d89d 100755 --- a/main.nf +++ b/main.nf @@ -557,3 +557,4 @@ workflow.onComplete { //////////////////////////////////////////////////// /* -- THE END -- */ //////////////////////////////////////////////////// + From 85109084e1602ce78e0a43216ab0f8776b55d5e6 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Thu, 30 Jul 2020 22:13:03 +0100 Subject: [PATCH 100/538] Fix markdownlint --- docs/README.md | 4 ++-- docs/usage.md | 8 ++++---- 2 files changed, 6 insertions(+), 6 deletions(-) diff --git a/docs/README.md b/docs/README.md index 84fa58441..2a650655f 100644 --- a/docs/README.md +++ b/docs/README.md @@ -5,8 +5,8 @@ The nf-core/chipseq documentation is split into the following pages: * [Usage](usage.md) - * An overview of how the pipeline works, how to run it and a description of all of the different command-line flags. + * An overview of how the pipeline works, how to run it and a description of all of the different command-line flags. * [Output](output.md) - * An overview of the different results produced by the pipeline and how to interpret them. + * An overview of the different results produced by the pipeline and how to interpret them. You can find a lot more documentation about installing, configuring and running nf-core pipelines on the website: [https://nf-co.re](https://nf-co.re) diff --git a/docs/usage.md b/docs/usage.md index 51efd810b..381ed10d8 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -139,11 +139,11 @@ They are loaded in sequence, so later profiles can overwrite earlier profiles. If `-profile` is not specified, the pipeline will run locally and expect all software to be installed and available on the `PATH`. This is _not_ recommended. * `docker` - * A generic configuration profile to be used with [Docker](https://docker.com/) - * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Docker](https://docker.com/) + * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) * `singularity` - * A generic configuration profile to be used with [Singularity](https://sylabs.io/docs/) - * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Singularity](https://sylabs.io/docs/) + * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) * `conda` * Please only use Conda as a last resort i.e. when it's not possible to run the pipeline with Docker or Singularity. * A generic configuration profile to be used with [Conda](https://conda.io/docs/) From 8918c1d7f5feb1b2fe60c0bf63f22826d770fa82 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 31 Jul 2020 09:21:57 +0100 Subject: [PATCH 101/538] Update schema --- main.nf | 7 +-- nextflow_schema.json | 145 ++++++++++++++++--------------------------- 2 files changed, 56 insertions(+), 96 deletions(-) diff --git a/main.nf b/main.nf index 75f59d89d..abad061f5 100755 --- a/main.nf +++ b/main.nf @@ -40,7 +40,7 @@ params.gtf = params.genome ? params.genomes[ params.genome ].gtf ?: false : fals params.gene_bed = params.genome ? params.genomes[ params.genome ].bed12 ?: false : false params.macs_gsize = params.genome ? params.genomes[ params.genome ].macs_gsize ?: false : false params.blacklist = params.genome ? params.genomes[ params.genome ].blacklist ?: false : false -params.anno_readme = params.genome ? params.genomes[ params.genome ].readme ?: false : false +anno_readme = params.genome ? params.genomes[ params.genome ].readme ?: false : false //////////////////////////////////////////////////// /* -- VALIDATE INPUTS -- */ @@ -61,9 +61,9 @@ if (params.fasta) { } // Save AWS IGenomes file containing annotation version -if (params.anno_readme && file(params.anno_readme).exists()) { +if (anno_readme && file(anno_readme).exists()) { file("${params.outdir}/genome/").mkdirs() - file(params.anno_readme).copyTo("${params.outdir}/genome/") + file(anno_readme).copyTo("${params.outdir}/genome/") } // If --gtf is supplied along with --genome @@ -557,4 +557,3 @@ workflow.onComplete { //////////////////////////////////////////////////// /* -- THE END -- */ //////////////////////////////////////////////////// - diff --git a/nextflow_schema.json b/nextflow_schema.json index 5b6cb78fb..fb2fa22c1 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -8,6 +8,11 @@ "input_output_options": { "title": "Input/output options", "type": "object", + "fa_icon": "fas fa-terminal", + "description": "Define where the pipeline should find input data and save output data.", + "required": [ + "input" + ], "properties": { "input": { "type": "string", @@ -19,8 +24,7 @@ "type": "integer", "default": 0, "description": "Estimated fragment size used to extend single-end reads.", - "fa_icon": "fas fa-chart-area", - "help_text": "" + "fa_icon": "fas fa-chart-area" }, "seq_center": { "type": "string", @@ -31,35 +35,32 @@ "type": "string", "description": "Path to the output directory where the results will be saved.", "default": "./results", - "fa_icon": "fas fa-folder-open", - "help_text": "" + "fa_icon": "fas fa-folder-open" }, "email": { "type": "string", "description": "Email address for completion summary.", "fa_icon": "fas fa-envelope", - "help_text": "An email address to send a summary email to when the pipeline is completed.", + "help_text": "Set this parameter to your e-mail address to get a summary e-mail with details of the run sent to you when the workflow exits. If set in your user config file (`~/.nextflow/config`) then you don't need to specify this on the command line for every run.", "pattern": "^([a-zA-Z0-9_\\-\\.]+)@([a-zA-Z0-9_\\-\\.]+)\\.([a-zA-Z]{2,5})$" } - }, - "required": [ - "input" - ], - "fa_icon": "fas fa-terminal" + } }, "reference_genome_options": { "title": "Reference genome options", "type": "object", + "fa_icon": "fas fa-dna", + "description": "Options for the reference genome indices used to align reads.", "properties": { "genome": { "type": "string", "description": "Name of iGenomes reference.", "fa_icon": "fas fa-book", - "help_text": "If using a reference genome configured in the pipeline using iGenomes, use this parameter to give the ID for the reference. This is then used to build the full paths for all required reference genome files e.g. `--genome GRCh38`." + "help_text": "If using a reference genome configured in the pipeline using iGenomes, use this parameter to give the ID for the reference. This is then used to build the full paths for all required reference genome files e.g. `--genome GRCh38`. \n\nSee the [nf-core website docs](https://nf-co.re/usage/reference_genomes) for more details." }, "fasta": { "type": "string", - "description": "Path to Fasta reference file.", + "description": "Path to FASTA genome file.", "help_text": "This parameter is *mandatory* if `--genome` is not specified. If you don't have a BWA index available this will be generated for you automatically. Combine with `--save_reference` to save BWA index for future runs.", "fa_icon": "far fa-file-code" }, @@ -72,14 +73,12 @@ "bwa_index": { "type": "string", "description": "Full path to directory containing BWA index including base name. i.e. `/path/to/index/genome.fa`.", - "fa_icon": "fas fa-bezier-curve", - "help_text": "" + "fa_icon": "fas fa-bezier-curve" }, "gene_bed": { "type": "string", "description": "Path to BED file containing gene intervals. This will be created from the GTF file if not specified.", - "fa_icon": "fas fa-procedures", - "help_text": "" + "fa_icon": "fas fa-procedures" }, "macs_gsize": { "type": "string", @@ -95,7 +94,6 @@ }, "save_reference": { "type": "boolean", - "default": false, "description": "If generated by the pipeline save the BWA index in the results directory.", "help_text": "If the BWA index is generated by the pipeline use this parameter to save it to your results folder. These can then be used for future pipeline runs, reducing processing times.", "fa_icon": "fas fa-save" @@ -105,37 +103,33 @@ "description": "Directory / URL base for iGenomes references.", "default": "s3://ngi-igenomes/igenomes/", "fa_icon": "fas fa-cloud-download-alt", - "hidden": true, - "help_text": "" + "hidden": true }, "igenomes_ignore": { "type": "boolean", "description": "Do not load the iGenomes reference config.", "fa_icon": "fas fa-ban", "hidden": true, - "default": false, "help_text": "Do not load `igenomes.config` when running the pipeline. You may choose this option if you observe clashes between custom parameters and those supplied in `igenomes.config`." } - }, - "fa_icon": "fas fa-dna" + } }, "adapter_trimming_options": { "title": "Adapter trimming options", "type": "object", + "fa_icon": "fas fa-cut", "properties": { "clip_r1": { "type": "integer", "default": 0, "description": "Instructs Trim Galore to remove bp from the 5' end of read 1 (or single-end reads).", - "fa_icon": "fas fa-cut", - "help_text": "" + "fa_icon": "fas fa-cut" }, "clip_r2": { "type": "integer", "default": 0, "description": "Instructs Trim Galore to remove bp from the 5' end of read 2 (paired-end reads only).", - "fa_icon": "fas fa-cut", - "help_text": "" + "fa_icon": "fas fa-cut" }, "three_prime_clip_r1": { "type": "integer", @@ -158,34 +152,30 @@ }, "skip_trimming": { "type": "boolean", - "default": false, "description": "Skip the adapter trimming step.", "help_text": "Use this if your input FastQ files have already been trimmed outside of the workflow or if you're very confident that there is no adapter contamination in your data.", "fa_icon": "fas fa-fast-forward" }, "save_trimmed": { "type": "boolean", - "default": false, "description": "Save the trimmed FastQ files in the results directory.", "help_text": "By default, trimmed FastQ files will not be saved to the results directory. Specify this flag (or set to true in your config file) to copy these files to the results directory when complete.", "fa_icon": "fas fa-save" } - }, - "fa_icon": "fas fa-cut" + } }, "alignment_options": { "title": "Alignment options", "type": "object", + "fa_icon": "fas fa-map-signs", "properties": { "keep_dups": { "type": "boolean", - "default": false, "description": "Duplicate reads are not filtered from alignments.", "fa_icon": "fas fa-cart-arrow-down" }, "keep_multi_map": { "type": "boolean", - "default": false, "description": "Reads mapping to multiple locations are not filtered from alignments.", "fa_icon": "fas fa-cart-arrow-down" }, @@ -196,7 +186,6 @@ }, "save_align_intermeds": { "type": "boolean", - "default": false, "description": "Save the intermediate BAM files from the alignment step.", "help_text": "By default, intermediate BAM files will not be saved. The final BAM files created after the appropriate filtering step are always saved to limit storage usage. Set this parameter to also save other intermediate BAM files.", "fa_icon": "fas fa-save" @@ -206,27 +195,24 @@ "default": "$baseDir/assets/bamtools_filter_pe.json", "hidden": true, "description": "BAMTools JSON file with custom filters for paired-end data.", - "fa_icon": "fas fa-cog", - "help_text": "" + "fa_icon": "fas fa-cog" }, "bamtools_filter_se_config": { "type": "string", "default": "$baseDir/assets/bamtools_filter_se.json", "hidden": true, "description": "BAMTools JSON file with custom filters for single-end data.", - "fa_icon": "fas fa-cog", - "help_text": "" + "fa_icon": "fas fa-cog" } - }, - "fa_icon": "fas fa-map-signs" + } }, "peak_calling_options": { "title": "Peak calling options", "type": "object", + "fa_icon": "fas fa-chart-area", "properties": { "narrow_peak": { "type": "boolean", - "default": false, "description": "Run MACS2 in narrowPeak mode.", "help_text": "MACS2 is run by default with the [`--broad`](https://github.com/taoliu/MACS#--broad) flag. Specify this flag to call peaks in narrowPeak mode.", "fa_icon": "fas fa-arrows-alt-h" @@ -256,16 +242,13 @@ }, "save_macs_pileup": { "type": "boolean", - "default": false, "description": "Instruct MACS2 to create bedGraph files normalised to signal per million reads.", - "fa_icon": "fas fa-save", - "help_text": "" + "fa_icon": "fas fa-save" }, "skip_peak_qc": { "type": "boolean", "fa_icon": "fas fa-fast-forward", - "description": "Skip MACS2 peak QC plot generation.", - "default": false + "description": "Skip MACS2 peak QC plot generation." }, "skip_peak_annotation": { "type": "boolean", @@ -275,101 +258,89 @@ }, "skip_consensus_peaks": { "type": "boolean", - "default": false, "description": "Skip consensus peak generation, annotation and counting.", - "fa_icon": "fas fa-fast-forward", - "help_text": "" + "fa_icon": "fas fa-fast-forward" } - }, - "fa_icon": "fas fa-chart-area" + } }, "differential_analysis_options": { "title": "Differential analysis options", "type": "object", + "fa_icon": "fas fa-not-equal", "properties": { "deseq2_vst": { "type": "boolean", - "default": false, "description": "Use vst transformation instead of rlog with DESeq2.", "help_text": "See [DESeq2 docs](http://bioconductor.org/packages/devel/bioc/vignettes/DESeq2/inst/doc/DESeq2.html#data-transformations-and-visualization).", "fa_icon": "fas fa-dolly" }, "skip_diff_analysis": { "type": "boolean", - "default": false, "description": "Skip differential accessibility analysis.", - "fa_icon": "fas fa-fast-forward", - "help_text": "" + "fa_icon": "fas fa-fast-forward" } - }, - "fa_icon": "fas fa-not-equal" + } }, "process_skipping_options": { "title": "Process skipping options", "type": "object", + "fa_icon": "fas fa-fast-forward", "properties": { "skip_fastqc": { "type": "boolean", - "default": false, "description": "Skip FastQC.", "fa_icon": "fas fa-fast-forward" }, "skip_picard_metrics": { "type": "boolean", - "default": false, "description": "Skip Picard CollectMultipleMetrics.", "fa_icon": "fas fa-fast-forward" }, "skip_preseq": { "type": "boolean", - "default": false, "description": "Skip Preseq.", "fa_icon": "fas fa-fast-forward" }, "skip_plot_profile": { "type": "boolean", - "default": false, "description": "Skip deepTools plotProfile.", "fa_icon": "fas fa-fast-forward" }, "skip_plot_fingerprint": { "type": "boolean", - "default": false, "description": "Skip deepTools plotFingerprint.", "fa_icon": "fas fa-fast-forward" }, "skip_spp": { "type": "boolean", - "default": false, "description": "Skip Phantompeakqualtools.", "fa_icon": "fas fa-fast-forward" }, "skip_igv": { "type": "boolean", - "default": false, "description": "Skip IGV.", "fa_icon": "fas fa-fast-forward" }, "skip_multiqc": { "type": "boolean", - "default": false, "description": "Skip MultiQC.", "fa_icon": "fas fa-fast-forward" } - }, - "fa_icon": "fas fa-fast-forward" + } }, "institutional_config_options": { "title": "Institutional config options", "type": "object", + "fa_icon": "fas fa-university", + "description": "Parameters used to describe centralised config profiles. These should not be edited.", + "help_text": "The centralised nf-core configuration profiles use a handful of pipeline parameters to describe themselves. This information is then printed to the Nextflow log when you run a pipeline. You should not need to change these values when you run a pipeline.", "properties": { "custom_config_version": { "type": "string", "description": "Git commit id for Institutional configs.", "default": "master", "hidden": true, - "fa_icon": "fas fa-users-cog", - "help_text": "" + "fa_icon": "fas fa-users-cog" }, "custom_config_base": { "type": "string", @@ -383,40 +354,38 @@ "type": "string", "description": "Institutional configs hostname.", "hidden": true, - "fa_icon": "fas fa-users-cog", - "help_text": "" + "fa_icon": "fas fa-users-cog" }, "config_profile_description": { "type": "string", "description": "Institutional config description.", "hidden": true, - "fa_icon": "fas fa-users-cog", - "help_text": "" + "fa_icon": "fas fa-users-cog" }, "config_profile_contact": { "type": "string", "description": "Institutional config contact information.", "hidden": true, - "fa_icon": "fas fa-users-cog", - "help_text": "" + "fa_icon": "fas fa-users-cog" }, "config_profile_url": { "type": "string", "description": "Institutional config URL link.", "hidden": true, - "fa_icon": "fas fa-users-cog", - "help_text": "" + "fa_icon": "fas fa-users-cog" } - }, - "fa_icon": "fas fa-university" + } }, "max_job_request_options": { "title": "Max job request options", "type": "object", + "fa_icon": "fab fa-acquisitions-incorporated", + "description": "Set the top limit for requested resources for any single job.", + "help_text": "If you are running on a smaller system, a pipeline step requesting more resources than are available may cause the Nextflow to stop the run with an error. These options allow you to cap the maximum resources requested by any single job so that the pipeline will run on your system.\n\nNote that you can not _increase_ the resources requested by any job using these options. For that you will need your own configuration file. See [the nf-core website](https://nf-co.re/usage/configuration) for details.", "properties": { "max_cpus": { "type": "integer", - "description": "Maximum number of CPUs that can be requested for any single job.", + "description": "Maximum number of CPUs that can be requested for any single job.", "default": 16, "fa_icon": "fas fa-microchip", "hidden": true, @@ -438,18 +407,19 @@ "hidden": true, "help_text": "Use to set an upper-limit for the time requirement for each process. Should be a string in the format integer-unit e.g. `--max_time '2.h'`" } - }, - "fa_icon": "fab fa-acquisitions-incorporated" + } }, "generic_options": { "title": "Generic options", "type": "object", + "fa_icon": "fas fa-file-import", + "description": "Less common options for the pipeline, typically set in a config file.", + "help_text": "These options are common to all nf-core pipelines and allow you to customise some of the core preferences for how the pipeline runs.\n\nTypically these options would be set in a Nextflow config file loaded for all pipeline runs, such as `~/.nextflow/config`.", "properties": { "help": { "type": "boolean", "description": "Display help text.", "fa_icon": "fas fa-question-circle", - "default": false, "hidden": true }, "fingerprint_bins": { @@ -494,8 +464,6 @@ "type": "boolean", "description": "Send plain-text email instead of HTML.", "fa_icon": "fas fa-remove-format", - "default": false, - "help_text": "", "hidden": true }, "max_multiqc_email_size": { @@ -503,22 +471,18 @@ "description": "File size limit when attaching MultiQC reports to summary emails.", "default": "25.MB", "fa_icon": "fas fa-file-upload", - "help_text": "", "hidden": true }, "monochrome_logs": { "type": "boolean", "description": "Do not use coloured log outputs.", "fa_icon": "fas fa-palette", - "default": false, - "help_text": "", "hidden": true }, "multiqc_config": { "type": "string", "description": "Custom config file to supply to MultiQC.", "fa_icon": "fas fa-cog", - "help_text": "", "hidden": true }, "tracedir": { @@ -526,18 +490,15 @@ "description": "Directory to keep pipeline Nextflow logs and reports.", "default": "${params.outdir}/pipeline_info", "fa_icon": "fas fa-cogs", - "help_text": "", "hidden": true }, "clusterOptions": { "type": "string", "description": "Arguments passed to Nextflow clusterOptions.", "fa_icon": "fas fa-network-wired", - "help_text": "", "hidden": true } - }, - "fa_icon": "fas fa-file-import" + } } }, "allOf": [ From 2fc644458261373ca5538c84754dd47670cf9f53 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 31 Jul 2020 09:52:01 +0100 Subject: [PATCH 102/538] Add missing params --- nextflow_schema.json | 39 ++++++++++++++++++++++++--------------- 1 file changed, 24 insertions(+), 15 deletions(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index fb2fa22c1..7f0508616 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -22,7 +22,6 @@ }, "fragment_size": { "type": "integer", - "default": 0, "description": "Estimated fragment size used to extend single-end reads.", "fa_icon": "fas fa-chart-area" }, @@ -50,7 +49,7 @@ "title": "Reference genome options", "type": "object", "fa_icon": "fas fa-dna", - "description": "Options for the reference genome indices used to align reads.", + "description": "Reference genome related files and options required for the workflow.", "properties": { "genome": { "type": "string", @@ -121,31 +120,26 @@ "properties": { "clip_r1": { "type": "integer", - "default": 0, "description": "Instructs Trim Galore to remove bp from the 5' end of read 1 (or single-end reads).", "fa_icon": "fas fa-cut" }, "clip_r2": { "type": "integer", - "default": 0, "description": "Instructs Trim Galore to remove bp from the 5' end of read 2 (paired-end reads only).", "fa_icon": "fas fa-cut" }, "three_prime_clip_r1": { "type": "integer", - "default": 0, "description": "Instructs Trim Galore to remove bp from the 3' end of read 1 AFTER adapter/quality trimming has been performed.", "fa_icon": "fas fa-cut" }, "three_prime_clip_r2": { "type": "integer", - "default": 0, "description": "Instructs Trim Galore to remove bp from the 3' end of read 2 AFTER adapter/quality trimming has been performed.", "fa_icon": "fas fa-cut" }, "trim_nextseq": { "type": "integer", - "default": 0, "description": "Instructs Trim Galore to apply the --nextseq=X option, to trim based on quality after removing poly-G tails.", "help_text": "This enables the option Cutadapt `--nextseq-trim=3'CUTOFF` option via Trim Galore, which will set a quality cutoff (that is normally given with -q instead), but qualities of G bases are ignored. This trimming is in common for the NextSeq- and NovaSeq-platforms, where basecalls without any signal are called as high-quality G bases.", "fa_icon": "fas fa-cut" @@ -162,7 +156,8 @@ "help_text": "By default, trimmed FastQ files will not be saved to the results directory. Specify this flag (or set to true in your config file) to copy these files to the results directory when complete.", "fa_icon": "fas fa-save" } - } + }, + "description": "Options to adjust adapter trimming criteria." }, "alignment_options": { "title": "Alignment options", @@ -204,7 +199,8 @@ "description": "BAMTools JSON file with custom filters for single-end data.", "fa_icon": "fas fa-cog" } - } + }, + "description": "Options to adjust parameters and filtering criteria for read alignments." }, "peak_calling_options": { "title": "Peak calling options", @@ -253,15 +249,15 @@ "skip_peak_annotation": { "type": "boolean", "fa_icon": "fas fa-fast-forward", - "description": "Skip annotation of MACS2 and consensus peaks with HOMER.", - "default": false + "description": "Skip annotation of MACS2 and consensus peaks with HOMER." }, "skip_consensus_peaks": { "type": "boolean", "description": "Skip consensus peak generation, annotation and counting.", "fa_icon": "fas fa-fast-forward" } - } + }, + "description": "Options to adjust peak calling criteria." }, "differential_analysis_options": { "title": "Differential analysis options", @@ -279,7 +275,8 @@ "description": "Skip differential accessibility analysis.", "fa_icon": "fas fa-fast-forward" } - } + }, + "description": "Options to adjust differential analysis criteria." }, "process_skipping_options": { "title": "Process skipping options", @@ -326,7 +323,8 @@ "description": "Skip MultiQC.", "fa_icon": "fas fa-fast-forward" } - } + }, + "description": "Options to skip various steps within the workflow." }, "institutional_config_options": { "title": "Institutional config options", @@ -497,6 +495,17 @@ "description": "Arguments passed to Nextflow clusterOptions.", "fa_icon": "fas fa-network-wired", "hidden": true + }, + "conda": { + "type": "boolean", + "description": "Run this workflow with Conda.", + "hidden": true + }, + "modules": { + "type": "string", + "default": "[samplesheet_check:[args:'', args2:'', publish_dir:'pipeline_info', publish_results:'', publish_by_id:false, suffix:''], fastqc:[args:'--quiet', args2:'', publish_dir:'fastqc', publish_results:'', publish_by_id:false, suffix:''], trimgalore:[args:'--fastqc', args2:'', publish_dir:'trimgalore', publish_results:'', publish_by_id:false, suffix:''], bwa_index:[args:'-a bwtsw', args2:'', publish_dir:'genome/bwa_index', publish_results:'', publish_by_id:false, suffix:''], gtf2bed:[args:'', args2:'', publish_dir:'genome', publish_results:'', publish_by_id:false, suffix:''], make_genome_filter:[args:'', args2:'', publish_dir:'genome', publish_results:'', publish_by_id:false, suffix:''], get_chrom_sizes:[args:'', args2:'', publish_dir:'genome', publish_results:'', publish_by_id:false, suffix:''], bwa_mem:[args:'-M', args2:'-h -F 0x0100 -O BAM', publish_dir:'bwa/library', publish_results:'', publish_by_id:false, suffix:'.Lb'], samtools_sort_lib:[args:'', args2:'', publish_dir:'bwa/library', publish_results:'', publish_by_id:false, suffix:'.Lb.sorted'], picard_mergesamfiles:[args:'SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp', args2:'', publish_dir:'bwa/mergedLibrary', publish_results:'', publish_by_id:false, suffix:'.mLb.sorted'], picard_markduplicates:[args:'ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp', args2:'', publish_dir:'bwa/mergedLibrary', publish_results:'', publish_by_id:false, suffix:'.mLb.mkD.sorted'], samtools_sort_merged_lib:[args:'', args2:'', publish_dir:'bwa/mergedLibrary', publish_results:'', publish_by_id:false, suffix:'.mLb.mkD.sorted'], bam_filter:[args:'', args2:'', publish_dir:'bwa/mergedLibrary', publish_results:'', publish_by_id:false, suffix:'.mLb.flT.sorted'], bam_remove_orphans:[args:'--only_fr_pairs', args2:'', publish_dir:'bwa/mergedLibrary', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], samtools_sort_filter:[args:'', args2:'', publish_dir:'bwa/mergedLibrary', publish_results:'', publish_by_id:false, suffix:'.mLb.clN.sorted'], picard_collectmultiplemetrics:[args:'VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp', args2:'', publish_dir:'bwa/mergedLibrary/picard_metrics', publish_results:'', publish_by_id:false, suffix:'.mLb.clN.sorted'], preseq_lcextrap:[args:'-verbose -bam -seed 1', args2:'', publish_dir:'bwa/mergedLibrary/preseq', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], phantompeakqualtools:[args:'', args2:'', publish_dir:'bwa/mergedLibrary/phantompeakqualtools', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], bedtools_genomecov:[args:'', args2:'', publish_dir:'bwa/mergedLibrary/bigwig', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], ucsc_bedgraphtobigwig:[args:'', args2:'', publish_dir:'bwa/mergedLibrary/bigwig', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], deeptools_computematrix:[args:'scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels', args2:'', publish_dir:'bwa/mergedLibrary/deeptools', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], deeptools_plotprofile:[args:'', args2:'', publish_dir:'bwa/mergedLibrary/deeptools', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], deeptools_plotheatmap:[args:'', args2:'', publish_dir:'bwa/mergedLibrary/deeptools', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], deeptools_plotfingerprint:[args:'--skipZeros', args2:'', publish_dir:'bwa/mergedLibrary/deeptools', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], macs2_callpeak:[args:'--keep-dup all', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:false, suffix:''], plot_macs2_qc:[args:'-o ./ -p macs2_peak', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:false, suffix:''], homer_annotatepeaks_macs2:[args:'-gid', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:false, suffix:'_peaks'], plot_homer_annotatepeaks:[args:'-o ./ -p macs2_annotatePeaks', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:false, suffix:''], macs2_consensus:[args:'', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:false, suffix:''], homer_annotatepeaks_consensus:[args:'-gid', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:true, suffix:'.consensus_peaks'], subread_featurecounts:[args:'-F SAF -O --fracOverlap 0.2', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:false, suffix:''], deseq2_featurecounts:[args:'', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:false, suffix:''], igv:[args:'', args2:'', publish_dir:'igv', publish_results:'', publish_by_id:false, suffix:''], get_software_versions:[args:'', args2:'', publish_dir:'pipeline_info', publish_results:'', publish_by_id:false, suffix:''], output_documentation:[args:'', args2:'', publish_dir:'pipeline_info', publish_results:'', publish_by_id:false, suffix:''], multiqc:[args:'', args2:'', publish_dir:'multiqc', publish_results:'', publish_by_id:false, suffix:'']]", + "description": "Parameter used to supply options to nf-core/modules files. Won't need to be provided on the command-line.", + "hidden": true } } } @@ -533,4 +542,4 @@ "$ref": "#/definitions/generic_options" } ] -} +} \ No newline at end of file From a4ba260994ebea738a220f0f4c8b276c1cf5211c Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 31 Jul 2020 09:55:37 +0100 Subject: [PATCH 103/538] Manually reorder descriptions for groups --- nextflow_schema.json | 24 ++++++++++++------------ 1 file changed, 12 insertions(+), 12 deletions(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index 7f0508616..c24063e1c 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -117,6 +117,7 @@ "title": "Adapter trimming options", "type": "object", "fa_icon": "fas fa-cut", + "description": "Options to adjust adapter trimming criteria.", "properties": { "clip_r1": { "type": "integer", @@ -156,13 +157,13 @@ "help_text": "By default, trimmed FastQ files will not be saved to the results directory. Specify this flag (or set to true in your config file) to copy these files to the results directory when complete.", "fa_icon": "fas fa-save" } - }, - "description": "Options to adjust adapter trimming criteria." + } }, "alignment_options": { "title": "Alignment options", "type": "object", "fa_icon": "fas fa-map-signs", + "description": "Options to adjust parameters and filtering criteria for read alignments.", "properties": { "keep_dups": { "type": "boolean", @@ -199,13 +200,13 @@ "description": "BAMTools JSON file with custom filters for single-end data.", "fa_icon": "fas fa-cog" } - }, - "description": "Options to adjust parameters and filtering criteria for read alignments." + } }, "peak_calling_options": { "title": "Peak calling options", "type": "object", "fa_icon": "fas fa-chart-area", + "description": "Options to adjust peak calling criteria.", "properties": { "narrow_peak": { "type": "boolean", @@ -256,13 +257,13 @@ "description": "Skip consensus peak generation, annotation and counting.", "fa_icon": "fas fa-fast-forward" } - }, - "description": "Options to adjust peak calling criteria." + } }, "differential_analysis_options": { "title": "Differential analysis options", "type": "object", "fa_icon": "fas fa-not-equal", + "description": "Options to adjust differential analysis criteria.", "properties": { "deseq2_vst": { "type": "boolean", @@ -275,13 +276,13 @@ "description": "Skip differential accessibility analysis.", "fa_icon": "fas fa-fast-forward" } - }, - "description": "Options to adjust differential analysis criteria." + } }, "process_skipping_options": { "title": "Process skipping options", "type": "object", "fa_icon": "fas fa-fast-forward", + "description": "Options to skip various steps within the workflow.", "properties": { "skip_fastqc": { "type": "boolean", @@ -323,8 +324,7 @@ "description": "Skip MultiQC.", "fa_icon": "fas fa-fast-forward" } - }, - "description": "Options to skip various steps within the workflow." + } }, "institutional_config_options": { "title": "Institutional config options", @@ -503,7 +503,7 @@ }, "modules": { "type": "string", - "default": "[samplesheet_check:[args:'', args2:'', publish_dir:'pipeline_info', publish_results:'', publish_by_id:false, suffix:''], fastqc:[args:'--quiet', args2:'', publish_dir:'fastqc', publish_results:'', publish_by_id:false, suffix:''], trimgalore:[args:'--fastqc', args2:'', publish_dir:'trimgalore', publish_results:'', publish_by_id:false, suffix:''], bwa_index:[args:'-a bwtsw', args2:'', publish_dir:'genome/bwa_index', publish_results:'', publish_by_id:false, suffix:''], gtf2bed:[args:'', args2:'', publish_dir:'genome', publish_results:'', publish_by_id:false, suffix:''], make_genome_filter:[args:'', args2:'', publish_dir:'genome', publish_results:'', publish_by_id:false, suffix:''], get_chrom_sizes:[args:'', args2:'', publish_dir:'genome', publish_results:'', publish_by_id:false, suffix:''], bwa_mem:[args:'-M', args2:'-h -F 0x0100 -O BAM', publish_dir:'bwa/library', publish_results:'', publish_by_id:false, suffix:'.Lb'], samtools_sort_lib:[args:'', args2:'', publish_dir:'bwa/library', publish_results:'', publish_by_id:false, suffix:'.Lb.sorted'], picard_mergesamfiles:[args:'SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp', args2:'', publish_dir:'bwa/mergedLibrary', publish_results:'', publish_by_id:false, suffix:'.mLb.sorted'], picard_markduplicates:[args:'ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp', args2:'', publish_dir:'bwa/mergedLibrary', publish_results:'', publish_by_id:false, suffix:'.mLb.mkD.sorted'], samtools_sort_merged_lib:[args:'', args2:'', publish_dir:'bwa/mergedLibrary', publish_results:'', publish_by_id:false, suffix:'.mLb.mkD.sorted'], bam_filter:[args:'', args2:'', publish_dir:'bwa/mergedLibrary', publish_results:'', publish_by_id:false, suffix:'.mLb.flT.sorted'], bam_remove_orphans:[args:'--only_fr_pairs', args2:'', publish_dir:'bwa/mergedLibrary', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], samtools_sort_filter:[args:'', args2:'', publish_dir:'bwa/mergedLibrary', publish_results:'', publish_by_id:false, suffix:'.mLb.clN.sorted'], picard_collectmultiplemetrics:[args:'VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp', args2:'', publish_dir:'bwa/mergedLibrary/picard_metrics', publish_results:'', publish_by_id:false, suffix:'.mLb.clN.sorted'], preseq_lcextrap:[args:'-verbose -bam -seed 1', args2:'', publish_dir:'bwa/mergedLibrary/preseq', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], phantompeakqualtools:[args:'', args2:'', publish_dir:'bwa/mergedLibrary/phantompeakqualtools', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], bedtools_genomecov:[args:'', args2:'', publish_dir:'bwa/mergedLibrary/bigwig', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], ucsc_bedgraphtobigwig:[args:'', args2:'', publish_dir:'bwa/mergedLibrary/bigwig', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], deeptools_computematrix:[args:'scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels', args2:'', publish_dir:'bwa/mergedLibrary/deeptools', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], deeptools_plotprofile:[args:'', args2:'', publish_dir:'bwa/mergedLibrary/deeptools', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], deeptools_plotheatmap:[args:'', args2:'', publish_dir:'bwa/mergedLibrary/deeptools', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], deeptools_plotfingerprint:[args:'--skipZeros', args2:'', publish_dir:'bwa/mergedLibrary/deeptools', publish_results:'', publish_by_id:false, suffix:'.mLb.clN'], macs2_callpeak:[args:'--keep-dup all', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:false, suffix:''], plot_macs2_qc:[args:'-o ./ -p macs2_peak', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:false, suffix:''], homer_annotatepeaks_macs2:[args:'-gid', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:false, suffix:'_peaks'], plot_homer_annotatepeaks:[args:'-o ./ -p macs2_annotatePeaks', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:false, suffix:''], macs2_consensus:[args:'', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:false, suffix:''], homer_annotatepeaks_consensus:[args:'-gid', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:true, suffix:'.consensus_peaks'], subread_featurecounts:[args:'-F SAF -O --fracOverlap 0.2', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:false, suffix:''], deseq2_featurecounts:[args:'', args2:'', publish_dir:'bwa/mergedLibrary/macs2', publish_results:'', publish_by_id:false, suffix:''], igv:[args:'', args2:'', publish_dir:'igv', publish_results:'', publish_by_id:false, suffix:''], get_software_versions:[args:'', args2:'', publish_dir:'pipeline_info', publish_results:'', publish_by_id:false, suffix:''], output_documentation:[args:'', args2:'', publish_dir:'pipeline_info', publish_results:'', publish_by_id:false, suffix:''], multiqc:[args:'', args2:'', publish_dir:'multiqc', publish_results:'', publish_by_id:false, suffix:'']]", + "default": "", "description": "Parameter used to supply options to nf-core/modules files. Won't need to be provided on the command-line.", "hidden": true } @@ -542,4 +542,4 @@ "$ref": "#/definitions/generic_options" } ] -} \ No newline at end of file +} From c094c1b9a53a01f49b24e6b8b696cd373d0180f0 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 31 Jul 2020 10:42:12 +0100 Subject: [PATCH 104/538] Update software versions script --- bin/scrape_software_versions.py | 0 1 file changed, 0 insertions(+), 0 deletions(-) mode change 100755 => 100644 bin/scrape_software_versions.py diff --git a/bin/scrape_software_versions.py b/bin/scrape_software_versions.py old mode 100755 new mode 100644 From 6c7b7a5a497e0cde2b02110d975739891da85c10 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 31 Jul 2020 10:43:47 +0100 Subject: [PATCH 105/538] Update permissions --- bin/scrape_software_versions.py | 0 1 file changed, 0 insertions(+), 0 deletions(-) mode change 100644 => 100755 bin/scrape_software_versions.py diff --git a/bin/scrape_software_versions.py b/bin/scrape_software_versions.py old mode 100644 new mode 100755 From a4f0629ef49bc3adac965670f57dd3dbe2a3536e Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 31 Jul 2020 10:47:27 +0100 Subject: [PATCH 106/538] Fix EOF literal sting error --- bin/scrape_software_versions.py | 69 ++++++++++++++++----------------- 1 file changed, 34 insertions(+), 35 deletions(-) diff --git a/bin/scrape_software_versions.py b/bin/scrape_software_versions.py index d0a512f6e..b294619f9 100755 --- a/bin/scrape_software_versions.py +++ b/bin/scrape_software_versions.py @@ -1,35 +1,34 @@ -#!/usr/bin/env python -from __future__ import print_function -import os - -results = {} -version_files = [x for x in os.listdir('.') if x.endswith('.version.txt')] -for version_file in version_files: - - software = version_file.replace('.version.txt','') - if software == 'pipeline': - software = 'nf-core/chipseq' - - with open(version_file) as fin: - version = fin.read().strip() - results[software] = version - -# Dump to YAML -print( - """ -id: 'software_versions' -section_name: 'nf-core/chipseq Software Versions' -section_href: 'https://github.com/nf-core/chipseq' -plot_type: 'html' -description: 'are collected at run time from the software output.' -data: | -
-''') -for k,v in sorted(results.items()): - print("
{}
{}
".format(k,v)) -print ("
") - -# Write out regexes as csv file: -with open('software_versions.csv', 'w') as f: - for k,v in sorted(results.items()): - f.write("{}\t{}\n".format(k,v)) +#!/usr/bin/env python +from __future__ import print_function +import os + +results = {} +version_files = [x for x in os.listdir('.') if x.endswith('.version.txt')] +for version_file in version_files: + + software = version_file.replace('.version.txt','') + if software == 'pipeline': + software = 'nf-core/chipseq' + + with open(version_file) as fin: + version = fin.read().strip() + results[software] = version + +# Dump to YAML +print (''' +id: 'software_versions' +section_name: 'nf-core/chipseq Software Versions' +section_href: 'https://github.com/nf-core/chipseq' +plot_type: 'html' +description: 'are collected at run time from the software output.' +data: | +
+''') +for k,v in sorted(results.items()): + print("
{}
{}
".format(k,v)) +print ("
") + +# Write out regexes as csv file: +with open('software_versions.csv', 'w') as f: + for k,v in sorted(results.items()): + f.write("{}\t{}\n".format(k,v)) From e91a23b9823d5b2b021a6cd6aa09b96dc182ba0c Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 31 Jul 2020 10:50:02 +0100 Subject: [PATCH 107/538] Arrrrggghhhh carriage returns --- bin/scrape_software_versions.py | 68 ++++++++++++++++----------------- 1 file changed, 34 insertions(+), 34 deletions(-) diff --git a/bin/scrape_software_versions.py b/bin/scrape_software_versions.py index b294619f9..e2b87c787 100755 --- a/bin/scrape_software_versions.py +++ b/bin/scrape_software_versions.py @@ -1,34 +1,34 @@ -#!/usr/bin/env python -from __future__ import print_function -import os - -results = {} -version_files = [x for x in os.listdir('.') if x.endswith('.version.txt')] -for version_file in version_files: - - software = version_file.replace('.version.txt','') - if software == 'pipeline': - software = 'nf-core/chipseq' - - with open(version_file) as fin: - version = fin.read().strip() - results[software] = version - -# Dump to YAML -print (''' -id: 'software_versions' -section_name: 'nf-core/chipseq Software Versions' -section_href: 'https://github.com/nf-core/chipseq' -plot_type: 'html' -description: 'are collected at run time from the software output.' -data: | -
-''') -for k,v in sorted(results.items()): - print("
{}
{}
".format(k,v)) -print ("
") - -# Write out regexes as csv file: -with open('software_versions.csv', 'w') as f: - for k,v in sorted(results.items()): - f.write("{}\t{}\n".format(k,v)) +#!/usr/bin/env python +from __future__ import print_function +import os + +results = {} +version_files = [x for x in os.listdir('.') if x.endswith('.version.txt')] +for version_file in version_files: + + software = version_file.replace('.version.txt','') + if software == 'pipeline': + software = 'nf-core/chipseq' + + with open(version_file) as fin: + version = fin.read().strip() + results[software] = version + +# Dump to YAML +print (''' +id: 'software_versions' +section_name: 'nf-core/chipseq Software Versions' +section_href: 'https://github.com/nf-core/chipseq' +plot_type: 'html' +description: 'are collected at run time from the software output.' +data: | +
+''') +for k,v in sorted(results.items()): + print("
{}
{}
".format(k,v)) +print ("
") + +# Write out regexes as csv file: +with open('software_versions.csv', 'w') as f: + for k,v in sorted(results.items()): + f.write("{}\t{}\n".format(k,v)) From 909fab938558c33274aff0f4cb73b53f52b2378f Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 31 Jul 2020 11:01:24 +0100 Subject: [PATCH 108/538] Change file permissions --- modules/local/process/get_software_versions.nf | 0 modules/local/process/multiqc.nf | 0 modules/local/process/output_documentation.nf | 0 modules/local/process/samplesheet_check.nf | 0 modules/nf-core/software/fastqc.nf | 0 5 files changed, 0 insertions(+), 0 deletions(-) mode change 100755 => 100644 modules/local/process/get_software_versions.nf mode change 100755 => 100644 modules/local/process/multiqc.nf mode change 100755 => 100644 modules/local/process/output_documentation.nf mode change 100755 => 100644 modules/local/process/samplesheet_check.nf mode change 100755 => 100644 modules/nf-core/software/fastqc.nf diff --git a/modules/local/process/get_software_versions.nf b/modules/local/process/get_software_versions.nf old mode 100755 new mode 100644 diff --git a/modules/local/process/multiqc.nf b/modules/local/process/multiqc.nf old mode 100755 new mode 100644 diff --git a/modules/local/process/output_documentation.nf b/modules/local/process/output_documentation.nf old mode 100755 new mode 100644 diff --git a/modules/local/process/samplesheet_check.nf b/modules/local/process/samplesheet_check.nf old mode 100755 new mode 100644 diff --git a/modules/nf-core/software/fastqc.nf b/modules/nf-core/software/fastqc.nf old mode 100755 new mode 100644 From 0d27926c043c9d1e3e921fa12b4423d31b0e80fc Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 31 Jul 2020 12:09:13 +0100 Subject: [PATCH 109/538] Add in first pass IGV --- conf/modules.config | 3 +- main.nf | 23 ++++++++----- modules/local/process/igv.nf | 64 +++++++++++++++++++++--------------- 3 files changed, 55 insertions(+), 35 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 6d9425a83..98da7e7ac 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -193,7 +193,8 @@ modules['plot_homer_annotatepeaks'] = modules['macs2_consensus'] = module_options ( - publish_dir : "bwa/mergedLibrary/macs2" + publish_dir : "bwa/mergedLibrary/macs2", + publish_by_id : true ) modules['homer_annotatepeaks_consensus'] = diff --git a/main.nf b/main.nf index abad061f5..3a173dc28 100755 --- a/main.nf +++ b/main.nf @@ -142,7 +142,7 @@ include { PLOT_MACS2_QC } from './modules/local/process/plot_macs2_qc include { MACS2_CONSENSUS } from './modules/local/process/macs2_consensus' //include { FRIP_SCORE } from './modules/local/process/frip_score' //include { DESEQ2_FEATURECOUNTS } from './modules/local/process/deseq2_featurecounts' -//include { IGV } from './modules/local/process/igv' +include { IGV } from './modules/local/process/igv' include { OUTPUT_DOCUMENTATION } from './modules/local/process/output_documentation' include { GET_SOFTWARE_VERSIONS } from './modules/local/process/get_software_versions' include { MULTIQC } from './modules/local/process/multiqc' @@ -359,12 +359,12 @@ workflow { params.modules['deeptools_plotfingerprint'] ) + peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' if (params.macs_gsize) { /* * Call peaks */ - peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' broad = params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}" pileup = params.save_macs_pileup ? '--bdg --SPMR' : '' fdr = params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '' @@ -478,12 +478,19 @@ workflow { } - // /* - // * Create IGV session - // */ - // IGV ( - // params.modules['igv'] - // ) + /* + * Create IGV session + */ + IGV ( + ch_fasta, + UCSC_BEDRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), + MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), + MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), + params.modules['ucsc_bedgraphtobigwig'], + params.modules['macs2_callpeak'], + params.modules['macs2_consensus'], + params.modules['igv'] + ) /* * Pipeline reporting diff --git a/modules/local/process/igv.nf b/modules/local/process/igv.nf index e1d94bbfb..f7c7bae9b 100644 --- a/modules/local/process/igv.nf +++ b/modules/local/process/igv.nf @@ -1,26 +1,38 @@ -//conda (params.conda ? "${baseDir}/environment.yml" : null) -// /* -// * STEP 8: Create IGV session file -// */ -// process IGV { -// publishDir "${params.outdir}/igv/${PEAK_TYPE}", mode: params.publish_dir_mode -// -// when: -// !params.skip_igv -// -// input: -// path fasta from ch_fasta -// path bigwigs from ch_bigwig_igv.collect().ifEmpty([]) -// path peaks from ch_macs_igv.collect().ifEmpty([]) -// path consensus_peaks from ch_macs_consensus_igv.collect().ifEmpty([]) -// path differential_peaks from ch_macs_consensus_deseq_comp_igv.collect().ifEmpty([]) -// -// output: -// path '*.{txt,xml}' -// -// script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ -// """ -// cat *.txt > igv_files.txt -// igv_files_to_session.py igv_session.xml igv_files.txt ../../genome/${fasta.getName()} --path_prefix '../../' -// """ -// } +/* + * Create IGV session file + */ +process IGV { + publishDir "${params.outdir}/${options.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (options.publish_results == "none") null + else filename } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + path fasta + path ("${bigwig_options.publish_dir}/*") + path ("${peak_options.publish_dir}/*") + path ("${consensus_options.publish_dir}/*") + val bigwig_options + val peak_options + val consensus_options + // path differential_peaks from ch_macs_consensus_deseq_comp_igv.collect().ifEmpty([]) + val options + + output: + path "*files.txt", emit: txt + path "*.xml", emit: xml + + script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ + """ + find * -type l -name "*.bigWig" -exec echo -e ""{}"\\t0,0,178" \\; > bigwig.igv.txt + find * -type l -name "*Peak" -exec echo -e ""{}"\\t0,0,178" \\; > peaks.igv.txt + + cat *.txt > igv_files.txt + igv_files_to_session.py igv_session.xml igv_files.txt ../../genome/${fasta.getName()} --path_prefix '../../' + """ +} +// find * -type f -name "${prefix}.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/"{}"\\t0,0,0" \\; > ${prefix}.bed.igv.txt +// find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt From 2b4006be820e69e798ff04aa9d2f5d58f6061add Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 31 Jul 2020 12:14:39 +0100 Subject: [PATCH 110/538] Add in SPP process --- main.nf | 2 +- modules/local/process/multiqc.nf | 2 +- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/main.nf b/main.nf index 3a173dc28..f39e4199f 100755 --- a/main.nf +++ b/main.nf @@ -539,7 +539,7 @@ workflow { PRESEQ_LCEXTRAP.out.ccurve.collect{it[1]}.ifEmpty([]), DEEPTOOLS_PLOTPROFILE.out.table.collect{it[1]}.ifEmpty([]), DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect{it[1]}.ifEmpty([]), - // path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) + PHANTOMPEAKQUALTOOLS.out.spp.collect{it[1]}.ifEmpty([]), // path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) diff --git a/modules/local/process/multiqc.nf b/modules/local/process/multiqc.nf index 0f2572091..6e9003f1a 100644 --- a/modules/local/process/multiqc.nf +++ b/modules/local/process/multiqc.nf @@ -47,7 +47,7 @@ process MULTIQC { path ('preseq/*') path ('deeptools/*') path ('deeptools/*') - // path ('phantompeakqualtools/*') from ch_spp_out_mqc.collect().ifEmpty([]) + path ('phantompeakqualtools/*') // path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) From 4e763e1a828f8bc0daa531b35404eb710fde8a53 Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Fri, 31 Jul 2020 13:19:48 +0200 Subject: [PATCH 111/538] Template update for nf-core/tools version 1.10.2 --- .github/CONTRIBUTING.md | 2 +- .github/workflows/awsfulltest.yml | 2 +- .github/workflows/branch.yml | 1 + .github/workflows/linting.yml | 9 ++++- .github/workflows/push_dockerhub.yml | 53 ++++++++++++++-------------- Dockerfile | 2 +- conf/test_full.config | 2 +- docs/usage.md | 2 +- main.nf | 2 +- 9 files changed, 42 insertions(+), 33 deletions(-) diff --git a/.github/CONTRIBUTING.md b/.github/CONTRIBUTING.md index 6ab73766c..cb1a4e6d7 100644 --- a/.github/CONTRIBUTING.md +++ b/.github/CONTRIBUTING.md @@ -46,7 +46,7 @@ These tests are run both with the latest available version of `Nextflow` and als ## Patch -: warning: Only in the unlikely and regretful event of a release happening with a bug. +:warning: Only in the unlikely and regretful event of a release happening with a bug. * On your own fork, make a new branch `patch` based on `upstream/master`. * Fix the bug, and bump version (X.Y.Z+1). diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index b6305e000..75a51e5fe 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -21,7 +21,7 @@ jobs: run: conda install -c conda-forge awscli - name: Start AWS batch job # TODO nf-core: You can customise AWS full pipeline tests as required - # Add full size test data (but still relatively small datasets for few samples) + # Add full size test data (but still relatively small datasets for few samples) # on the `test_full.config` test runs with only one set of parameters # Then specify `-profile test_full` instead of `-profile test` on the AWS batch command env: diff --git a/.github/workflows/branch.yml b/.github/workflows/branch.yml index 492b3ab3d..93e0f4f87 100644 --- a/.github/workflows/branch.yml +++ b/.github/workflows/branch.yml @@ -17,6 +17,7 @@ jobs: # If the above check failed, post a comment on the PR explaining the failure + # NOTE - this doesn't currently work if the PR is coming from a fork, due to limitations in GitHub actions secrets - name: Post PR comment if: failure() uses: mshick/add-pr-comment@v1 diff --git a/.github/workflows/linting.yml b/.github/workflows/linting.yml index eb66c1449..8e8d5bbcf 100644 --- a/.github/workflows/linting.yml +++ b/.github/workflows/linting.yml @@ -57,5 +57,12 @@ jobs: GITHUB_COMMENTS_URL: ${{ github.event.pull_request.comments_url }} GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }} GITHUB_PR_COMMIT: ${{ github.event.pull_request.head.sha }} - run: nf-core lint ${GITHUB_WORKSPACE} + run: nf-core -l lint_log.txt lint ${GITHUB_WORKSPACE} + + - name: Upload linting log file artifact + if: ${{ always() }} + uses: actions/upload-artifact@v2 + with: + name: linting-log-file + path: lint_log.txt diff --git a/.github/workflows/push_dockerhub.yml b/.github/workflows/push_dockerhub.yml index 96d7636c9..9a9f84a4c 100644 --- a/.github/workflows/push_dockerhub.yml +++ b/.github/workflows/push_dockerhub.yml @@ -8,32 +8,33 @@ on: release: types: [published] -push_dockerhub: - name: Push new Docker image to Docker Hub - runs-on: ubuntu-latest - # Only run for the nf-core repo, for releases and merged PRs - if: ${{ github.repository == 'nf-core/chipseq' }} - env: - DOCKERHUB_USERNAME: ${{ secrets.DOCKERHUB_USERNAME }} - DOCKERHUB_PASS: ${{ secrets.DOCKERHUB_PASS }} - steps: - - name: Check out pipeline code - uses: actions/checkout@v2 +jobs: + push_dockerhub: + name: Push new Docker image to Docker Hub + runs-on: ubuntu-latest + # Only run for the nf-core repo, for releases and merged PRs + if: ${{ github.repository == 'nf-core/chipseq' }} + env: + DOCKERHUB_USERNAME: ${{ secrets.DOCKERHUB_USERNAME }} + DOCKERHUB_PASS: ${{ secrets.DOCKERHUB_PASS }} + steps: + - name: Check out pipeline code + uses: actions/checkout@v2 - - name: Build new docker image - run: docker build --no-cache . -t nfcore/chipseq:latest + - name: Build new docker image + run: docker build --no-cache . -t nfcore/chipseq:latest - - name: Push Docker image to DockerHub (dev) - if: ${{ github.event_name == 'push' }} - run: | - echo "$DOCKERHUB_PASS" | docker login -u "$DOCKERHUB_USERNAME" --password-stdin - docker tag nfcore/chipseq:latest nfcore/chipseq:dev - docker push nfcore/chipseq:dev + - name: Push Docker image to DockerHub (dev) + if: ${{ github.event_name == 'push' }} + run: | + echo "$DOCKERHUB_PASS" | docker login -u "$DOCKERHUB_USERNAME" --password-stdin + docker tag nfcore/chipseq:latest nfcore/chipseq:dev + docker push nfcore/chipseq:dev - - name: Push Docker image to DockerHub (release) - if: ${{ github.event_name == 'release' }} - run: | - echo "$DOCKERHUB_PASS" | docker login -u "$DOCKERHUB_USERNAME" --password-stdin - docker push nfcore/chipseq:latest - docker tag nfcore/chipseq:latest nfcore/chipseq:${{ github.event.release.tag_name }} - docker push nfcore/chipseq:${{ github.event.release.tag_name }} + - name: Push Docker image to DockerHub (release) + if: ${{ github.event_name == 'release' }} + run: | + echo "$DOCKERHUB_PASS" | docker login -u "$DOCKERHUB_USERNAME" --password-stdin + docker push nfcore/chipseq:latest + docker tag nfcore/chipseq:latest nfcore/chipseq:${{ github.event.release.tag_name }} + docker push nfcore/chipseq:${{ github.event.release.tag_name }} diff --git a/Dockerfile b/Dockerfile index 0e2e359d6..b739ba3eb 100644 --- a/Dockerfile +++ b/Dockerfile @@ -1,4 +1,4 @@ -FROM nfcore/base:1.10.1 +FROM nfcore/base:1.10.2 LABEL authors="Philip Ewels" \ description="Docker image containing all software requirements for the nf-core/chipseq pipeline" diff --git a/conf/test_full.config b/conf/test_full.config index deedc3a34..5ed014407 100644 --- a/conf/test_full.config +++ b/conf/test_full.config @@ -15,7 +15,7 @@ params { // TODO nf-core: Specify the paths to your full test data ( on nf-core/test-datasets or directly in repositories, e.g. SRA) // TODO nf-core: Give any required params for the test so that command line flags are not needed single_end = false - readPaths = [ + input_paths = [ ['Testdata', ['https://github.com/nf-core/test-datasets/raw/exoseq/testdata/Testdata_R1.tiny.fastq.gz', 'https://github.com/nf-core/test-datasets/raw/exoseq/testdata/Testdata_R2.tiny.fastq.gz']], ['SRR389222', ['https://github.com/nf-core/test-datasets/raw/methylseq/testdata/SRR389222_sub1.fastq.gz', 'https://github.com/nf-core/test-datasets/raw/methylseq/testdata/SRR389222_sub2.fastq.gz']] ] diff --git a/docs/usage.md b/docs/usage.md index ba405e485..ceaa7dd4d 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -80,7 +80,7 @@ You can also supply a run name to resume a specific run: `-resume [run-name]`. U ### `-c` -Specify the path to a specific config file (this is a core NextFlow command). See the [nf-core website documentation](https://nf-co.re/usage/configuration) for more information. +Specify the path to a specific config file (this is a core Nextflow command). See the [nf-core website documentation](https://nf-co.re/usage/configuration) for more information. #### Custom resource requests diff --git a/main.nf b/main.nf index 15a4dfcce..76ded6ac2 100644 --- a/main.nf +++ b/main.nf @@ -127,7 +127,7 @@ def summary = [:] if (workflow.revision) summary['Pipeline Release'] = workflow.revision summary['Run Name'] = custom_runName ?: workflow.runName // TODO nf-core: Report custom parameters here -summary['Reads'] = params.input +summary['Input'] = params.input summary['Fasta Ref'] = params.fasta summary['Data Type'] = params.single_end ? 'Single-End' : 'Paired-End' summary['Max Resources'] = "$params.max_memory memory, $params.max_cpus cpus, $params.max_time time per job" From 2906eb5f1bc4773705d8a83e4835ca811cf9290b Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 31 Jul 2020 14:06:26 +0100 Subject: [PATCH 112/538] Add in first batch of custom MultiQC custom content --- assets/multiqc_config.yaml | 2 + conf/modules.config | 13 +++- main.nf | 71 ++++++++++++------- modules/local/process/frip_score.nf | 30 +++++++- modules/local/process/multiqc.nf | 6 +- .../multiqc_custom_phantompeakqualtools.nf | 33 +++++++++ .../nf-core/software/phantompeakqualtools.nf | 3 +- 7 files changed, 126 insertions(+), 32 deletions(-) create mode 100644 modules/local/process/multiqc_custom_phantompeakqualtools.nf diff --git a/assets/multiqc_config.yaml b/assets/multiqc_config.yaml index 4d795e5da..ba2b7b0e7 100644 --- a/assets/multiqc_config.yaml +++ b/assets/multiqc_config.yaml @@ -167,3 +167,5 @@ sp: fn: '*plotFingerprint*' deeptools/plotProfile: fn: '*plotProfile*' + phantompeakqualtools/out: + fn: '*.spp.out' diff --git a/conf/modules.config b/conf/modules.config index 98da7e7ac..cef4d58fe 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -10,7 +10,7 @@ def module_options (Map args) { options.args = args.args ?: '' options.args2 = args.args2 ?: '' options.publish_dir = args.publish_dir ?: '' - options.publish_results = args.publish_results ?: '' + options.publish_results = args.publish_results ?: 'all' options.publish_by_id = args.publish_by_id ?: false options.suffix = args.suffix ?: '' return options @@ -128,6 +128,11 @@ modules['phantompeakqualtools'] = suffix : ".mLb.clN" ) +modules['multiqc_custom_phantompeakqualtools'] = + module_options ( + publish_results : "none" + ) + modules['bedtools_genomecov'] = module_options ( publish_dir : "bwa/mergedLibrary/bigwig", @@ -172,6 +177,12 @@ modules['macs2_callpeak'] = publish_dir : "bwa/mergedLibrary/macs2" ) +modules['frip_score'] = + module_options ( + args : "-bed -c -f 0.20", + publish_results : "none" + ) + modules['plot_macs2_qc'] = module_options ( args : "-o ./ -p macs2_peak", diff --git a/main.nf b/main.nf index f39e4199f..34302e74d 100755 --- a/main.nf +++ b/main.nf @@ -99,17 +99,16 @@ ch_output_docs_images = file("$baseDir/docs/images/", checkIfExists: true) // JSON files required by BAMTools for alignment filtering ch_bamtools_filter_se_config = file(params.bamtools_filter_se_config, checkIfExists: true) ch_bamtools_filter_pe_config = file(params.bamtools_filter_pe_config, checkIfExists: true) -//ch_bamtools_filter_config // Header files for MultiQC +ch_spp_nsc_header = file("$baseDir/assets/multiqc/spp_nsc_header.txt", checkIfExists: true) +ch_spp_rsc_header = file("$baseDir/assets/multiqc/spp_rsc_header.txt", checkIfExists: true) +ch_spp_correlation_header = file("$baseDir/assets/multiqc/spp_correlation_header.txt", checkIfExists: true) ch_peak_count_header = file("$baseDir/assets/multiqc/peak_count_header.txt", checkIfExists: true) ch_frip_score_header = file("$baseDir/assets/multiqc/frip_score_header.txt", checkIfExists: true) ch_peak_annotation_header = file("$baseDir/assets/multiqc/peak_annotation_header.txt", checkIfExists: true) ch_deseq2_pca_header = file("$baseDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) ch_deseq2_clustering_header = file("$baseDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) -ch_spp_correlation_header = file("$baseDir/assets/multiqc/spp_correlation_header.txt", checkIfExists: true) -ch_spp_nsc_header = file("$baseDir/assets/multiqc/spp_nsc_header.txt", checkIfExists: true) -ch_spp_rsc_header = file("$baseDir/assets/multiqc/spp_rsc_header.txt", checkIfExists: true) //////////////////////////////////////////////////// /* -- PARAMETER SUMMARY -- */ @@ -133,22 +132,23 @@ log.info "-\033[2m----------------------------------------------------\033[0m-" /* -- IMPORT LOCAL MODULES/SUBWORKFLOWS -- */ //////////////////////////////////////////////////// -include { GTF2BED } from './modules/local/process/gtf2bed' -include { GET_CHROM_SIZES } from './modules/local/process/get_chrom_sizes' -include { MAKE_GENOME_FILTER } from './modules/local/process/make_genome_filter' -include { BEDTOOLS_GENOMECOV } from './modules/local/process/bedtools_genomecov' -include { PLOT_HOMER_ANNOTATEPEAKS } from './modules/local/process/plot_homer_annotatepeaks' -include { PLOT_MACS2_QC } from './modules/local/process/plot_macs2_qc' -include { MACS2_CONSENSUS } from './modules/local/process/macs2_consensus' -//include { FRIP_SCORE } from './modules/local/process/frip_score' -//include { DESEQ2_FEATURECOUNTS } from './modules/local/process/deseq2_featurecounts' -include { IGV } from './modules/local/process/igv' -include { OUTPUT_DOCUMENTATION } from './modules/local/process/output_documentation' -include { GET_SOFTWARE_VERSIONS } from './modules/local/process/get_software_versions' -include { MULTIQC } from './modules/local/process/multiqc' - -include { INPUT_CHECK } from './modules/local/subworkflow/input_check' -include { BAM_CLEAN } from './modules/local/subworkflow/bam_clean' +include { GTF2BED } from './modules/local/process/gtf2bed' +include { GET_CHROM_SIZES } from './modules/local/process/get_chrom_sizes' +include { MAKE_GENOME_FILTER } from './modules/local/process/make_genome_filter' +include { BEDTOOLS_GENOMECOV } from './modules/local/process/bedtools_genomecov' +include { PLOT_HOMER_ANNOTATEPEAKS } from './modules/local/process/plot_homer_annotatepeaks' +include { PLOT_MACS2_QC } from './modules/local/process/plot_macs2_qc' +include { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS } from './modules/local/process/multiqc_custom_phantompeakqualtools' +include { MACS2_CONSENSUS } from './modules/local/process/macs2_consensus' +include { FRIP_SCORE } from './modules/local/process/frip_score' +//include { DESEQ2_FEATURECOUNTS } from './modules/local/process/deseq2_featurecounts' +include { IGV } from './modules/local/process/igv' +include { OUTPUT_DOCUMENTATION } from './modules/local/process/output_documentation' +include { GET_SOFTWARE_VERSIONS } from './modules/local/process/get_software_versions' +include { MULTIQC } from './modules/local/process/multiqc' + +include { INPUT_CHECK } from './modules/local/subworkflow/input_check' +include { BAM_CLEAN } from './modules/local/subworkflow/bam_clean' //////////////////////////////////////////////////// /* -- IMPORT NF-CORE MODULES/SUBWORKFLOWS -- */ @@ -296,6 +296,14 @@ workflow { ) ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null)) + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( + PHANTOMPEAKQUALTOOLS.out.spp.join(PHANTOMPEAKQUALTOOLS.out.rdata, by: [0]), + ch_spp_nsc_header, + ch_spp_rsc_header, + ch_spp_correlation_header, + params.modules['multiqc_custom_phantompeakqualtools'] + ) + /* * Coverage tracks */ @@ -384,11 +392,24 @@ workflow { ) ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.version.first().ifEmpty(null)) + + ch_ip_control_bam + .join(MACS2_CALLPEAK.out.peak, by: [0]) + .map { it -> [ it[0], it[1], it[3] ] } + .set { ch_ip_peak } + FRIP_SCORE ( + ch_ip_peak, + params.modules['frip_score'] + ) + //| cat $frip_score_header - > ${ip}_peaks.FRiP_mqc.tsv + params.modules['plot_macs2_qc'].publish_dir += "/$peakType/qc" PLOT_MACS2_QC ( MACS2_CALLPEAK.out.peak.collect{it[1]}, params.modules['plot_macs2_qc'] ) + // ch_peak_count_header = file("$baseDir/assets/multiqc/peak_count_header.txt", checkIfExists: true) + // ch_frip_score_header = file("$baseDir/assets/multiqc/frip_score_header.txt", checkIfExists: true) params.modules['homer_annotatepeaks_macs2'].publish_dir += "/$peakType" HOMER_ANNOTATEPEAKS_MACS2 ( @@ -405,6 +426,7 @@ workflow { "_peaks.annotatePeaks.txt", params.modules['plot_homer_annotatepeaks'] ) + //ch_peak_annotation_header = file("$baseDir/assets/multiqc/peak_annotation_header.txt", checkIfExists: true) // Create channel: [ meta , [ peaks ] ] // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] @@ -468,13 +490,12 @@ workflow { ) ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) - // FRIP_SCORE ( - // params.modules['frip_score'] - // ) // // DESEQ2_FEATURECOUNTS ( // params.modules['deseq2_featurecounts'] // ) + // ch_deseq2_pca_header = file("$baseDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) + // ch_deseq2_clustering_header = file("$baseDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) } @@ -540,7 +561,9 @@ workflow { DEEPTOOLS_PLOTPROFILE.out.table.collect{it[1]}.ifEmpty([]), DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect{it[1]}.ifEmpty([]), PHANTOMPEAKQUALTOOLS.out.spp.collect{it[1]}.ifEmpty([]), - // path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.nsc.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.rsc.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.correlation.collect{it[1]}.ifEmpty([]), // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) // path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) diff --git a/modules/local/process/frip_score.nf b/modules/local/process/frip_score.nf index 3ccc18853..5ec357456 100644 --- a/modules/local/process/frip_score.nf +++ b/modules/local/process/frip_score.nf @@ -1,4 +1,28 @@ -conda (params.conda ? "${baseDir}/environment.yml" : null) +process FRIP_SCORE { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (options.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } -READS_IN_PEAKS=\$(intersectBed -a ${ipbam[0]} -b ${ip}_peaks.${PEAK_TYPE} -bed -c -f 0.20 | awk -F '\t' '{sum += \$NF} END {print sum}') -grep 'mapped (' $ipflagstat | awk -v a="\$READS_IN_PEAKS" -v OFS='\t' '{print "${ip}", a/\$1}' | cat $frip_score_header - > ${ip}_peaks.FRiP_mqc.tsv + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + tuple val(meta), path(bam), path(peak) + val options + + output: + tuple val(meta), path("*.txt"), emit: txt + + script: + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + + """ + READS_IN_PEAKS=\$(intersectBed -a $bam -b $peak $options.args | awk -F '\t' '{sum += \$NF} END {print sum}') + samtools flagstat $bam > ${bam}.flagstat + grep 'mapped (' ${bam}.flagstat | awk -v a="\$READS_IN_PEAKS" -v OFS='\t' '{print "${prefix}", a/\$1}' > ${prefix}.FRiP.txt + """ +} diff --git a/modules/local/process/multiqc.nf b/modules/local/process/multiqc.nf index 6e9003f1a..53a464600 100644 --- a/modules/local/process/multiqc.nf +++ b/modules/local/process/multiqc.nf @@ -48,8 +48,10 @@ process MULTIQC { path ('deeptools/*') path ('deeptools/*') path ('phantompeakqualtools/*') - // path ('phantompeakqualtools/*') from ch_spp_csv_mqc.collect().ifEmpty([]) - + path ('phantompeakqualtools/*') + path ('phantompeakqualtools/*') + path ('phantompeakqualtools/*') + // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) // path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) path ('featurecounts/*') diff --git a/modules/local/process/multiqc_custom_phantompeakqualtools.nf b/modules/local/process/multiqc_custom_phantompeakqualtools.nf new file mode 100644 index 000000000..6b79fcc72 --- /dev/null +++ b/modules/local/process/multiqc_custom_phantompeakqualtools.nf @@ -0,0 +1,33 @@ +process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { + tag "$meta.id" + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (options.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + tuple val(meta), path(spp), path(rdata) + path nsc_header + path rsc_header + path correlation_header + val options + + output: + tuple val(meta), path("*.spp_nsc_mqc.tsv"), emit: nsc + tuple val(meta), path("*.spp_rsc_mqc.tsv"), emit: rsc + tuple val(meta), path("*.spp_correlation_mqc.tsv"), emit: correlation + + script: + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + """ + cp $correlation_header ${prefix}.spp_correlation_mqc.tsv + Rscript -e "load('$rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}.spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" + + awk -v OFS='\t' '{print "${meta.id}", \$9}' $spp | cat $nsc_header - > ${prefix}.spp_nsc_mqc.tsv + awk -v OFS='\t' '{print "${meta.id}", \$10}' $spp | cat $rsc_header - > ${prefix}.spp_rsc_mqc.tsv + """ +} diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf index 8d072bab2..beaf754b0 100644 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ b/modules/nf-core/software/phantompeakqualtools.nf @@ -23,6 +23,7 @@ process PHANTOMPEAKQUALTOOLS { output: tuple val(meta), path("*.out"), emit: spp tuple val(meta), path("*.pdf"), emit: pdf + tuple val(meta), path("*.Rdata"), emit: rdata path "*.version.txt", emit: version script: @@ -30,8 +31,6 @@ process PHANTOMPEAKQUALTOOLS { """ RUN_SPP=`which run_spp.R` Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus - Rscript -e "load('${prefix}.spp.Rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}_spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" - echo $VERSION > ${SOFTWARE}.version.txt """ } From b0e311c742084e157215d3041036df61288f6d68 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 31 Jul 2020 14:45:47 +0100 Subject: [PATCH 113/538] Add in custom peaks --- conf/modules.config | 5 ++++ main.nf | 20 +++++++++---- modules/local/process/multiqc.nf | 7 +++-- modules/local/process/multiqc_custom_peaks.nf | 28 +++++++++++++++++++ 4 files changed, 52 insertions(+), 8 deletions(-) create mode 100644 modules/local/process/multiqc_custom_peaks.nf diff --git a/conf/modules.config b/conf/modules.config index cef4d58fe..057b30af9 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -183,6 +183,11 @@ modules['frip_score'] = publish_results : "none" ) +modules['multiqc_custom_peaks'] = + module_options ( + publish_results : "none" + ) + modules['plot_macs2_qc'] = module_options ( args : "-o ./ -p macs2_peak", diff --git a/main.nf b/main.nf index 34302e74d..3419eaaed 100755 --- a/main.nf +++ b/main.nf @@ -139,6 +139,7 @@ include { BEDTOOLS_GENOMECOV } from './modules/local/process/be include { PLOT_HOMER_ANNOTATEPEAKS } from './modules/local/process/plot_homer_annotatepeaks' include { PLOT_MACS2_QC } from './modules/local/process/plot_macs2_qc' include { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS } from './modules/local/process/multiqc_custom_phantompeakqualtools' +include { MULTIQC_CUSTOM_PEAKS } from './modules/local/process/multiqc_custom_peaks' include { MACS2_CONSENSUS } from './modules/local/process/macs2_consensus' include { FRIP_SCORE } from './modules/local/process/frip_score' //include { DESEQ2_FEATURECOUNTS } from './modules/local/process/deseq2_featurecounts' @@ -392,7 +393,6 @@ workflow { ) ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.version.first().ifEmpty(null)) - ch_ip_control_bam .join(MACS2_CALLPEAK.out.peak, by: [0]) .map { it -> [ it[0], it[1], it[3] ] } @@ -401,15 +401,23 @@ workflow { ch_ip_peak, params.modules['frip_score'] ) - //| cat $frip_score_header - > ${ip}_peaks.FRiP_mqc.tsv + + ch_ip_peak + .join(FRIP_SCORE.out.txt, by: [0]) + .map { it -> [ it[0], it[2], it[3] ] } + .set { ch_ip_peak_frip } + MULTIQC_CUSTOM_PEAKS ( + ch_ip_peak_frip, + ch_peak_count_header, + ch_frip_score_header, + params.modules['multiqc_custom_peaks'] + ) params.modules['plot_macs2_qc'].publish_dir += "/$peakType/qc" PLOT_MACS2_QC ( MACS2_CALLPEAK.out.peak.collect{it[1]}, params.modules['plot_macs2_qc'] ) - // ch_peak_count_header = file("$baseDir/assets/multiqc/peak_count_header.txt", checkIfExists: true) - // ch_frip_score_header = file("$baseDir/assets/multiqc/frip_score_header.txt", checkIfExists: true) params.modules['homer_annotatepeaks_macs2'].publish_dir += "/$peakType" HOMER_ANNOTATEPEAKS_MACS2 ( @@ -426,6 +434,7 @@ workflow { "_peaks.annotatePeaks.txt", params.modules['plot_homer_annotatepeaks'] ) + //cat $peak_annotation_header macs_annotatePeaks.summary.txt > macs_annotatePeaks.summary_mqc.tsv //ch_peak_annotation_header = file("$baseDir/assets/multiqc/peak_annotation_header.txt", checkIfExists: true) // Create channel: [ meta , [ peaks ] ] @@ -565,7 +574,8 @@ workflow { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.rsc.collect{it[1]}.ifEmpty([]), MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.correlation.collect{it[1]}.ifEmpty([]), - // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) + MULTIQC_CUSTOM_PEAKS.out.count.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PEAKS.out.frip.collect{it[1]}.ifEmpty([]), // path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) diff --git a/modules/local/process/multiqc.nf b/modules/local/process/multiqc.nf index 53a464600..6441d7285 100644 --- a/modules/local/process/multiqc.nf +++ b/modules/local/process/multiqc.nf @@ -51,9 +51,10 @@ process MULTIQC { path ('phantompeakqualtools/*') path ('phantompeakqualtools/*') path ('phantompeakqualtools/*') - - // path ('macs/*') from ch_macs_mqc.collect().ifEmpty([]) - // path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) + + path ('macs2/peaks/*') + path ('macs2/peaks/*') + // path ('macs2/annotation*') from ch_macs_qc_mqc.collect().ifEmpty([]) path ('featurecounts/*') // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) diff --git a/modules/local/process/multiqc_custom_peaks.nf b/modules/local/process/multiqc_custom_peaks.nf new file mode 100644 index 000000000..a6a918010 --- /dev/null +++ b/modules/local/process/multiqc_custom_peaks.nf @@ -0,0 +1,28 @@ +process MULTIQC_CUSTOM_PEAKS { + tag "$meta.id" + publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + mode: params.publish_dir_mode, + saveAs: { filename -> + if (options.publish_results == "none") null + else if (filename.endsWith('.version.txt')) null + else filename } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + tuple val(meta), path(peak), path(frip) + path peak_count_header + path frip_score_header + val options + + output: + tuple val(meta), path("*.peak_count_mqc.tsv"), emit: count + tuple val(meta), path("*.FRiP_mqc.tsv"), emit: frip + + script: + prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + """ + cat $peak | wc -l | awk -v OFS='\t' '{ print "${prefix}", \$1 }' | cat $peak_count_header - > ${prefix}.peak_count_mqc.tsv + cat $frip_score_header $frip > ${prefix}.FRiP_mqc.tsv + """ +} From 85570fce21e9d4c9037cc32a98d4027af8e380fd Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 31 Jul 2020 15:05:51 +0100 Subject: [PATCH 114/538] Add custom annotatepeaks to MultiQC --- assets/multiqc_config.yaml | 2 ++ main.nf | 7 +++---- modules/local/process/multiqc.nf | 3 ++- modules/local/process/plot_homer_annotatepeaks.nf | 4 ++++ 4 files changed, 11 insertions(+), 5 deletions(-) diff --git a/assets/multiqc_config.yaml b/assets/multiqc_config.yaml index ba2b7b0e7..6d9df4a06 100644 --- a/assets/multiqc_config.yaml +++ b/assets/multiqc_config.yaml @@ -149,6 +149,8 @@ extra_fn_clean_exts: - 'clN' - 'mLb' - '_peaks' + - '.FRiP' + - '.peak' - '_spp' - '.spp' - 'ccurve' diff --git a/main.nf b/main.nf index 3419eaaed..3c392545b 100755 --- a/main.nf +++ b/main.nf @@ -431,11 +431,10 @@ workflow { params.modules['plot_homer_annotatepeaks'].publish_dir += "/$peakType/qc" PLOT_HOMER_ANNOTATEPEAKS ( HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, + ch_peak_annotation_header, "_peaks.annotatePeaks.txt", params.modules['plot_homer_annotatepeaks'] ) - //cat $peak_annotation_header macs_annotatePeaks.summary.txt > macs_annotatePeaks.summary_mqc.tsv - //ch_peak_annotation_header = file("$baseDir/assets/multiqc/peak_annotation_header.txt", checkIfExists: true) // Create channel: [ meta , [ peaks ] ] // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] @@ -576,8 +575,8 @@ workflow { MULTIQC_CUSTOM_PEAKS.out.count.collect{it[1]}.ifEmpty([]), MULTIQC_CUSTOM_PEAKS.out.frip.collect{it[1]}.ifEmpty([]), - // path ('macs/*') from ch_macs_qc_mqc.collect().ifEmpty([]) - SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), + PLOT_HOMER_ANNOTATEPEAKS.out.tsv.collect{it[1]}.ifEmpty([]), + SUBREAD_FEATURECOUNTS.out.summary.collect().ifEmpty([]), // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) params.modules['multiqc'] diff --git a/modules/local/process/multiqc.nf b/modules/local/process/multiqc.nf index 6441d7285..15b78e953 100644 --- a/modules/local/process/multiqc.nf +++ b/modules/local/process/multiqc.nf @@ -54,7 +54,8 @@ process MULTIQC { path ('macs2/peaks/*') path ('macs2/peaks/*') - // path ('macs2/annotation*') from ch_macs_qc_mqc.collect().ifEmpty([]) + path ('macs2/annotation*') + path ('featurecounts/*') // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) diff --git a/modules/local/process/plot_homer_annotatepeaks.nf b/modules/local/process/plot_homer_annotatepeaks.nf index b2e25bd87..d4ec3f196 100644 --- a/modules/local/process/plot_homer_annotatepeaks.nf +++ b/modules/local/process/plot_homer_annotatepeaks.nf @@ -13,12 +13,14 @@ process PLOT_HOMER_ANNOTATEPEAKS { input: path annos + path mqc_header val suffix val options output: path '*.txt', emit: txt path '*.pdf', emit: pdf + path '*.tsv', emit: tsv script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ """ @@ -26,5 +28,7 @@ process PLOT_HOMER_ANNOTATEPEAKS { -i ${annos.join(',')} \\ -s ${annos.join(',').replaceAll("${suffix}","")} \\ $options.args + + find ./ -type f -name "*.txt" -exec cat {} \\; | cat $mqc_header - > annotatepeaks.summary_mqc.tsv """ } From 454c0dd1c7da85576f7da1837c7971ae6a4b5db3 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Fri, 31 Jul 2020 15:29:27 +0100 Subject: [PATCH 115/538] Fix MultiQC report --- main.nf | 4 ++-- modules/local/process/multiqc.nf | 4 ++-- 2 files changed, 4 insertions(+), 4 deletions(-) diff --git a/main.nf b/main.nf index 3c392545b..caf6e30f6 100755 --- a/main.nf +++ b/main.nf @@ -575,8 +575,8 @@ workflow { MULTIQC_CUSTOM_PEAKS.out.count.collect{it[1]}.ifEmpty([]), MULTIQC_CUSTOM_PEAKS.out.frip.collect{it[1]}.ifEmpty([]), - PLOT_HOMER_ANNOTATEPEAKS.out.tsv.collect{it[1]}.ifEmpty([]), - SUBREAD_FEATURECOUNTS.out.summary.collect().ifEmpty([]), + PLOT_HOMER_ANNOTATEPEAKS.out.tsv.collect().ifEmpty([]), + SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) params.modules['multiqc'] diff --git a/modules/local/process/multiqc.nf b/modules/local/process/multiqc.nf index 15b78e953..15d64be86 100644 --- a/modules/local/process/multiqc.nf +++ b/modules/local/process/multiqc.nf @@ -54,8 +54,8 @@ process MULTIQC { path ('macs2/peaks/*') path ('macs2/peaks/*') - path ('macs2/annotation*') - + path ('macs2/annotation/*') + path ('featurecounts/*') // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) From a4d63b978e2fc7d263db618b730acf24158dafb1 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 3 Aug 2020 10:44:49 +0100 Subject: [PATCH 116/538] Add local functions --- modules/nf-core/software/bwa_index.nf | 46 +++++++++++++++++++++++---- 1 file changed, 40 insertions(+), 6 deletions(-) diff --git a/modules/nf-core/software/bwa_index.nf b/modules/nf-core/software/bwa_index.nf index 5cdf4c1ba..bade7c393 100644 --- a/modules/nf-core/software/bwa_index.nf +++ b/modules/nf-core/software/bwa_index.nf @@ -1,20 +1,52 @@ def SOFTWARE = 'bwa' +// Function to initialise default values and to generate a Groovy Map of module options +def init_options (Map args, String publish_dir) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.suffix = args.suffix ?: '' + options.publish_dir = args.publish_dir ? args.publish_dir : publish_dir + options.publish_files = args.publish_files ?: null + options.publish_by_id = args.publish_by_id ?: false + return options +} + +// Function to publish module results + // if publish_files == null - all files are published + // if publish_files == Map [:] - no files are published + // if publish_files == Map [ext:path] - Only files that end with "ext" are published to "path" appended to output directory +def publish_options ( filename, publish_files ) { + if (publish_files instanceof Map) { + if (!publish_files.isEmpty()) { + if (!filename.endsWith('.version.txt')) { + filename + // Loop through extensions and paths here + } + } + } + else { + if (!filename.endsWith('.version.txt')) filename + } +} + process BWA_INDEX { tag "$fasta" label 'process_high' - publishDir "${params.outdir}/${options.publish_dir}", - mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + //if (module_options.publish_files) { + publishDir "${params.outdir}/${options.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> publish_options( filename, module_options.publish_files ) } + //} container "biocontainers/bwa:v0.7.17_cv1" //container "https://depot.galaxyproject.org/singularity/bwa:0.7.17--hed695b0_7" conda (params.conda ? "bioconda::bwa=0.7.17" : null) + //echo true + //cache false + input: path fasta val options @@ -24,7 +56,9 @@ process BWA_INDEX { path "*.version.txt", emit: version script: + def module_options = init_options(options, SOFTWARE) """ + echo $module_options bwa index $options.args $fasta echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${SOFTWARE}.version.txt """ From bded91f86322a4a901b9e14fd73324c7b57e5abd Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 3 Aug 2020 16:15:08 +0100 Subject: [PATCH 117/538] Use groovy funcs for publishing --- conf/modules.config | 414 ++++++-------- main.nf | 786 +++++++++++++------------- modules/nf-core/software/bwa_index.nf | 49 +- 3 files changed, 570 insertions(+), 679 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 057b30af9..7131e68f4 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -2,255 +2,171 @@ * ------------------------------------------------- * Nextflow config file for module specific-options * ------------------------------------------------- + * + * Available keys to override module options: + * args = Additional arguments appended to command in module. + * args2 = Second set of arguments appended to command in module (multi-tool modules). + * publish_by_id = Publish results in separate folders by meta.id value. + * publish_dir = Directory to publish results. + * publish_files = Groovy map where key = "file_ext" and value = "directory" to only publish results + * for a particular file extension. The value of "directory" is appended to the standard + * "publish_dir" path as defined above. + * suffix = File name suffix for output files */ -// Function to initialise default values and to generate a Groovy Map of module options -def module_options (Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_dir = args.publish_dir ?: '' - options.publish_results = args.publish_results ?: 'all' - options.publish_by_id = args.publish_by_id ?: false - options.suffix = args.suffix ?: '' - return options +params { + modules { + 'samplesheet_check' { + publish_dir = "pipeline_info" + } + 'fastqc' { + args = "--quiet" + } + 'trimgalore' { + args = "--fastqc" + } + 'bwa_index' { + args = "-a bwtsw" + publish_dir = "genome/bwa_index" + } + 'gtf2bed' { + publish_dir = "genome" + } + 'make_genome_filter' { + publish_dir = "genome" + } + 'get_chrom_sizes' { + publish_dir = "genome" + } + 'bwa_mem' { + args = "-M" + args2 = "-h -F 0x0100 -O BAM" + publish_dir = "bwa/library" + suffix = ".Lb" + } + 'samtools_sort_lib' { + publish_dir = "bwa/library" + suffix = ".Lb.sorted" + } + 'picard_mergesamfiles' { + args = "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.sorted" + } + 'picard_markduplicates' { + args = "ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.mkD.sorted" + } + 'samtools_sort_merged_lib' { + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.mkD.sorted" + } + 'bam_filter' { + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.flT.sorted" + } + 'bam_remove_orphans' { + args = "--only_fr_pairs" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.clN" + } + 'samtools_sort_filter' { + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.clN.sorted" + } + 'picard_collectmultiplemetrics' { + args = "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" + publish_dir = "bwa/mergedLibrary/picard_metrics" + suffix = ".mLb.clN.sorted" + } + 'preseq_lcextrap' { + args = "-verbose -bam -seed 1" + publish_dir = "bwa/mergedLibrary/preseq" + suffix = ".mLb.clN" + } + 'phantompeakqualtools' { + publish_dir = "bwa/mergedLibrary/phantompeakqualtools" + suffix = ".mLb.clN" + } + 'multiqc_custom_phantompeakqualtools' { + publish_files = [:] + } + 'bedtools_genomecov' { + publish_dir = "bwa/mergedLibrary/bigwig" + suffix = ".mLb.clN" + } + 'ucsc_bedgraphtobigwig' { + publish_dir = "bwa/mergedLibrary/bigwig" + suffix = ".mLb.clN" + } + 'deeptools_computematrix' { + args = "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels" + publish_dir = "bwa/mergedLibrary/deeptools" + suffix = ".mLb.clN" + } + 'deeptools_plotprofile' { + publish_dir = "bwa/mergedLibrary/deeptools" + suffix = ".mLb.clN" + } + 'deeptools_plotheatmap' { + publish_dir = "bwa/mergedLibrary/deeptools" + suffix = ".mLb.clN" + } + 'deeptools_plotfingerprint' { + args = "--skipZeros" + publish_dir = "bwa/mergedLibrary/deeptools" + suffix = ".mLb.clN" + } + 'macs2_callpeak' { + args = "--keep-dup all" + publish_dir = "bwa/mergedLibrary/macs2" + } + 'frip_score' { + args = "-bed -c -f 0.20" + publish_files = [:] + } + 'multiqc_custom_peaks' { + publish_files = [:] + } + 'plot_macs2_qc' { + args = "-o ./ -p macs2_peak" + publish_dir = "bwa/mergedLibrary/macs2" + } + 'homer_annotatepeaks_macs2' { + args = "-gid" + publish_dir = "bwa/mergedLibrary/macs2" + suffix = "_peaks" + } + 'plot_homer_annotatepeaks' { + args = "-o ./ -p macs2_annotatePeaks" + publish_dir = "bwa/mergedLibrary/macs2" + } + 'macs2_consensus' { + publish_dir = "bwa/mergedLibrary/macs2" + publish_by_id = true + } + 'homer_annotatepeaks_consensus' { + args = "-gid" + publish_dir = "bwa/mergedLibrary/macs2" + publish_by_id = true, + suffix = ".consensus_peaks" + } + 'subread_featurecounts' { + args = "-F SAF -O --fracOverlap 0.2" + publish_dir = "bwa/mergedLibrary/macs2" + } + 'deseq2_featurecounts' { + publish_dir = "bwa/mergedLibrary/macs2" + } + 'igv' { + publish_dir = "igv" + } + 'get_software_versions' { + publish_dir = "pipeline_info" + } + 'output_documentation' { + publish_dir = "pipeline_info" + } + } } - -def Map modules = [:] -modules['samplesheet_check'] = - module_options ( - publish_dir : "pipeline_info" - ) - -modules['fastqc'] = - module_options ( - args : "--quiet", - publish_dir : "fastqc" - ) - -modules['trimgalore'] = - module_options ( - args : "--fastqc", - publish_dir : "trimgalore" - ) - -modules['bwa_index'] = - module_options ( - args : "-a bwtsw", - publish_dir : "genome/bwa_index" - ) - -modules['gtf2bed'] = - module_options ( - publish_dir : "genome" - ) - -modules['make_genome_filter'] = - module_options ( - publish_dir : "genome" - ) - -modules['get_chrom_sizes'] = - module_options ( - publish_dir : "genome" - ) - -modules['bwa_mem'] = - module_options ( - args : "-M", - args2 : "-h -F 0x0100 -O BAM", - publish_dir : "bwa/library", - suffix : ".Lb" - ) - -modules['samtools_sort_lib'] = - module_options ( - publish_dir : "bwa/library", - suffix : ".Lb.sorted" - ) - -modules['picard_mergesamfiles'] = - module_options ( - args : "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp", - publish_dir : "bwa/mergedLibrary", - suffix : ".mLb.sorted" - ) - -modules['picard_markduplicates'] = - module_options ( - args : "ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp", - publish_dir : "bwa/mergedLibrary", - suffix : ".mLb.mkD.sorted" - ) - -modules['samtools_sort_merged_lib'] = - module_options ( - publish_dir : "bwa/mergedLibrary", - suffix : ".mLb.mkD.sorted" - ) - -modules['bam_filter'] = - module_options ( - publish_dir : "bwa/mergedLibrary", - suffix : ".mLb.flT.sorted" - ) - -modules['bam_remove_orphans'] = - module_options ( - args : "--only_fr_pairs", - publish_dir : "bwa/mergedLibrary", - suffix : ".mLb.clN" - ) - -modules['samtools_sort_filter'] = - module_options ( - publish_dir : "bwa/mergedLibrary", - suffix : ".mLb.clN.sorted" - ) - -modules['picard_collectmultiplemetrics'] = - module_options ( - args : "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp", - publish_dir : "bwa/mergedLibrary/picard_metrics", - suffix : ".mLb.clN.sorted" - ) - -modules['preseq_lcextrap'] = - module_options ( - args : "-verbose -bam -seed 1", - publish_dir : "bwa/mergedLibrary/preseq", - suffix : ".mLb.clN" - ) - -modules['phantompeakqualtools'] = - module_options ( - publish_dir : "bwa/mergedLibrary/phantompeakqualtools", - suffix : ".mLb.clN" - ) - -modules['multiqc_custom_phantompeakqualtools'] = - module_options ( - publish_results : "none" - ) - -modules['bedtools_genomecov'] = - module_options ( - publish_dir : "bwa/mergedLibrary/bigwig", - suffix : ".mLb.clN" - ) - -modules['ucsc_bedgraphtobigwig'] = - module_options ( - publish_dir : "bwa/mergedLibrary/bigwig", - suffix : ".mLb.clN" - ) - -modules['deeptools_computematrix'] = - module_options ( - args : "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels", - publish_dir : "bwa/mergedLibrary/deeptools", - suffix : ".mLb.clN" - ) - -modules['deeptools_plotprofile'] = - module_options ( - publish_dir : "bwa/mergedLibrary/deeptools", - suffix : ".mLb.clN" - ) - -modules['deeptools_plotheatmap'] = - module_options ( - publish_dir : "bwa/mergedLibrary/deeptools", - suffix : ".mLb.clN" - ) - -modules['deeptools_plotfingerprint'] = - module_options ( - args : "--skipZeros", - publish_dir : "bwa/mergedLibrary/deeptools", - suffix : ".mLb.clN" - ) - -modules['macs2_callpeak'] = - module_options ( - args : "--keep-dup all", - publish_dir : "bwa/mergedLibrary/macs2" - ) - -modules['frip_score'] = - module_options ( - args : "-bed -c -f 0.20", - publish_results : "none" - ) - -modules['multiqc_custom_peaks'] = - module_options ( - publish_results : "none" - ) - -modules['plot_macs2_qc'] = - module_options ( - args : "-o ./ -p macs2_peak", - publish_dir : "bwa/mergedLibrary/macs2" - ) - -modules['homer_annotatepeaks_macs2'] = - module_options ( - args : "-gid", - publish_dir : "bwa/mergedLibrary/macs2", - suffix : "_peaks" - ) - -modules['plot_homer_annotatepeaks'] = - module_options ( - args : "-o ./ -p macs2_annotatePeaks", - publish_dir : "bwa/mergedLibrary/macs2", - ) - -modules['macs2_consensus'] = - module_options ( - publish_dir : "bwa/mergedLibrary/macs2", - publish_by_id : true - ) - -modules['homer_annotatepeaks_consensus'] = - module_options ( - args : "-gid", - publish_dir : "bwa/mergedLibrary/macs2", - publish_by_id : true, - suffix : ".consensus_peaks" - ) - -modules['subread_featurecounts'] = - module_options ( - args : "-F SAF -O --fracOverlap 0.2", - publish_dir : "bwa/mergedLibrary/macs2", - suffix : "" - ) - -modules['deseq2_featurecounts'] = - module_options ( - publish_dir : "bwa/mergedLibrary/macs2" - ) - -modules['igv'] = - module_options ( - publish_dir : "igv" - ) - -modules['get_software_versions'] = - module_options ( - publish_dir : "pipeline_info" - ) - -modules['output_documentation'] = - module_options ( - publish_dir : "pipeline_info" - ) - -modules['multiqc'] = - module_options ( - publish_dir : "multiqc" - ) - -params.modules = modules diff --git a/main.nf b/main.nf index caf6e30f6..c13a5fd8b 100755 --- a/main.nf +++ b/main.nf @@ -192,395 +192,403 @@ workflow { /* * Prepare genome files */ - ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta, params.modules['bwa_index'] ).index - - if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf, params.modules['gtf2bed'] ) } - - MAKE_GENOME_FILTER ( - GET_CHROM_SIZES ( ch_fasta, params.modules['get_chrom_sizes'] ).sizes, - ch_blacklist.ifEmpty([]), - params.modules['make_genome_filter'] - ) - ch_software_versions = Channel.empty() - ch_software_versions = ch_software_versions.mix(MAKE_GENOME_FILTER.out.version.first().ifEmpty(null)) - - /* - * Read QC & trimming - */ - nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' - params.modules['trimgalore'].args += nextseq - FASTQC_TRIMGALORE ( - INPUT_CHECK.out.reads, - params.skip_fastqc, - params.skip_trimming, - params.modules['fastqc'], - params.modules['trimgalore'] - ) - ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.fastqc_version.first().ifEmpty(null)) - ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.trimgalore_version.first().ifEmpty(null)) - - /* - * Map reads & BAM QC - */ - score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' - params.modules['bwa_mem'].args += score - MAP_BWA_MEM ( - FASTQC_TRIMGALORE.out.reads, - ch_index, - ch_fasta, - params.modules['bwa_mem'], - params.modules['samtools_sort_lib'] - ) - ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.bwa_version.first()) - ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.samtools_version.first().ifEmpty(null)) - - /* - * Merge resequenced BAM files - */ - MAP_BWA_MEM - .out - .bam - .map { - meta, bam -> - fmeta = meta.findAll { it.key != 'read_group' } - fmeta.id = fmeta.id.split('_')[0..-2].join('_') - [ fmeta, bam ] } - .groupTuple(by: [0]) - .map { it -> [ it[0], it[1].flatten() ] } - .set { ch_sort_bam } - - PICARD_MERGESAMFILES ( - ch_sort_bam, - params.modules['picard_mergesamfiles'] - ) - ch_software_versions = ch_software_versions.mix(PICARD_MERGESAMFILES.out.version.first().ifEmpty(null)) - - /* - * Mark duplicates & filter BAM files - */ - MARK_DUPLICATES_PICARD ( - PICARD_MERGESAMFILES.out.bam, - params.modules['picard_markduplicates'], - params.modules['samtools_sort_merged_lib'] - ) - - // Fix getting name sorted BAM here for PE/SE - BAM_CLEAN ( - MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), - MAKE_GENOME_FILTER.out.bed.collect(), - ch_bamtools_filter_se_config, - ch_bamtools_filter_pe_config, - params.modules['bam_filter'], - params.modules['bam_remove_orphans'], - params.modules['samtools_sort_filter'] - ) - ch_software_versions = ch_software_versions.mix(BAM_CLEAN.out.bamtools_version.first().ifEmpty(null)) - - /* - * Post alignment QC - */ - PICARD_COLLECTMULTIPLEMETRICS ( - BAM_CLEAN.out.bam, - ch_fasta, - params.modules['picard_collectmultiplemetrics'] - ) - - PRESEQ_LCEXTRAP ( - BAM_CLEAN.out.bam, - params.modules['preseq_lcextrap'] - ) - ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) - - PHANTOMPEAKQUALTOOLS ( - BAM_CLEAN.out.bam, - params.modules['phantompeakqualtools'] - ) - ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null)) - - MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( - PHANTOMPEAKQUALTOOLS.out.spp.join(PHANTOMPEAKQUALTOOLS.out.rdata, by: [0]), - ch_spp_nsc_header, - ch_spp_rsc_header, - ch_spp_correlation_header, - params.modules['multiqc_custom_phantompeakqualtools'] - ) - - /* - * Coverage tracks - */ - BEDTOOLS_GENOMECOV ( - BAM_CLEAN.out.bam.join(BAM_CLEAN.out.flagstat, by: [0]), - params.modules['bedtools_genomecov'] - ) - - UCSC_BEDRAPHTOBIGWIG ( - BEDTOOLS_GENOMECOV.out.bedgraph, - GET_CHROM_SIZES.out.sizes, - params.modules['ucsc_bedgraphtobigwig'] - ) - ch_software_versions = ch_software_versions.mix(UCSC_BEDRAPHTOBIGWIG.out.version.first().ifEmpty(null)) - - /* - * Coverage plots - */ - DEEPTOOLS_COMPUTEMATRIX ( - UCSC_BEDRAPHTOBIGWIG.out.bigwig, - ch_gene_bed, - params.modules['deeptools_computematrix'] - ) - ch_software_versions = ch_software_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.version.first().ifEmpty(null)) - - DEEPTOOLS_PLOTPROFILE ( - DEEPTOOLS_COMPUTEMATRIX.out.matrix, - params.modules['deeptools_plotprofile'] - ) - - DEEPTOOLS_PLOTHEATMAP ( - DEEPTOOLS_COMPUTEMATRIX.out.matrix, - params.modules['deeptools_plotheatmap'] - ) - - /* - * Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] - */ - BAM_CLEAN - .out - .bam - .join ( BAM_CLEAN.out.bai, by: [0] ) - .map { meta, bam, bai -> meta.control ? null : [ meta.id, [ bam ] , [ bai ] ] } - .set { ch_control_bam_bai } - - BAM_CLEAN - .out - .bam - .join ( BAM_CLEAN.out.bai, by: [0] ) - .map { meta, bam, bai -> meta.control ? [ meta.control, meta, [ bam ], [ bai ] ] : null } - .combine(ch_control_bam_bai, by: 0) - .map { it -> [ it[1] , it[2] + it[4], it[3] + it[5] ] } - .set { ch_ip_control_bam_bai } - - /* - * plotFingerprint for IP and control together - */ - params.modules['deeptools_plotfingerprint'].args += " --numberOfSamples $params.fingerprint_bins" - DEEPTOOLS_PLOTFINGERPRINT ( - ch_ip_control_bam_bai, - params.modules['deeptools_plotfingerprint'] - ) - - peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' - if (params.macs_gsize) { - - /* - * Call peaks - */ - broad = params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}" - pileup = params.save_macs_pileup ? '--bdg --SPMR' : '' - fdr = params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '' - pvalue = params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' - params.modules['macs2_callpeak'].publish_dir += "/$peakType" - params.modules['macs2_callpeak'].args += " $broad $pileup $fdr $pvalue" - - // Create channel: [ val(meta), ip_bam, control_bam ] - ch_ip_control_bam_bai - .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } - .set { ch_ip_control_bam } - - MACS2_CALLPEAK ( - ch_ip_control_bam, - params.macs_gsize, - params.modules['macs2_callpeak'] - ) - ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.version.first().ifEmpty(null)) - - ch_ip_control_bam - .join(MACS2_CALLPEAK.out.peak, by: [0]) - .map { it -> [ it[0], it[1], it[3] ] } - .set { ch_ip_peak } - FRIP_SCORE ( - ch_ip_peak, - params.modules['frip_score'] - ) - - ch_ip_peak - .join(FRIP_SCORE.out.txt, by: [0]) - .map { it -> [ it[0], it[2], it[3] ] } - .set { ch_ip_peak_frip } - MULTIQC_CUSTOM_PEAKS ( - ch_ip_peak_frip, - ch_peak_count_header, - ch_frip_score_header, - params.modules['multiqc_custom_peaks'] - ) - - params.modules['plot_macs2_qc'].publish_dir += "/$peakType/qc" - PLOT_MACS2_QC ( - MACS2_CALLPEAK.out.peak.collect{it[1]}, - params.modules['plot_macs2_qc'] - ) - - params.modules['homer_annotatepeaks_macs2'].publish_dir += "/$peakType" - HOMER_ANNOTATEPEAKS_MACS2 ( - MACS2_CALLPEAK.out.peak, - ch_fasta, - ch_gtf, - params.modules['homer_annotatepeaks_macs2'] - ) - ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.version.first().ifEmpty(null)) - - params.modules['plot_homer_annotatepeaks'].publish_dir += "/$peakType/qc" - PLOT_HOMER_ANNOTATEPEAKS ( - HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, - ch_peak_annotation_header, - "_peaks.annotatePeaks.txt", - params.modules['plot_homer_annotatepeaks'] - ) - - // Create channel: [ meta , [ peaks ] ] - // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] - MACS2_CALLPEAK - .out - .peak - .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } - .groupTuple() - .map { - antibody, groups, peaks -> - [ antibody, - groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, - peaks ] } - .map { - antibody, groups, peaks -> - def meta = [:] - meta.id = antibody - meta.multiple_groups = groups.size() > 1 - meta.replicates_exist = groups.max { groups.value }.value > 1 - [ meta, peaks ] } - .set { ch_antibody_peaks } - - params.modules['macs2_consensus'].publish_dir += "/$peakType/consensus" - MACS2_CONSENSUS ( - ch_antibody_peaks, - params.modules['macs2_consensus'] - ) - - params.modules['homer_annotatepeaks_consensus'].publish_dir += "/$peakType/consensus" - HOMER_ANNOTATEPEAKS_CONSENSUS ( - MACS2_CONSENSUS.out.bed, - ch_fasta, - ch_gtf, - params.modules['homer_annotatepeaks_consensus'] - ) - // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt - // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt - - // Create channel: [ val(meta), ip_bam ] - MACS2_CONSENSUS - .out - .saf - .map { meta, saf -> [ meta.id, meta, saf ] } - .set { ch_ip_saf } - - ch_ip_control_bam - .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } - .combine(ch_ip_saf) - .map { - it -> - fmeta = it[1] - fmeta['replicates_exist'] = it[4]['replicates_exist'] - fmeta['multiple_groups'] = it[4]['multiple_groups'] - [ fmeta, it[2], it[5] ] } - .set { ch_ip_bam } - - params.modules['subread_featurecounts'].publish_dir += "/$peakType/consensus" - SUBREAD_FEATURECOUNTS ( - ch_ip_bam, - params.modules['subread_featurecounts'] - ) - ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) - - // - // DESEQ2_FEATURECOUNTS ( - // params.modules['deseq2_featurecounts'] - // ) - // ch_deseq2_pca_header = file("$baseDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) - // ch_deseq2_clustering_header = file("$baseDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) - - } - - /* - * Create IGV session - */ - IGV ( - ch_fasta, - UCSC_BEDRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), - MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), - MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), - params.modules['ucsc_bedgraphtobigwig'], - params.modules['macs2_callpeak'], - params.modules['macs2_consensus'], - params.modules['igv'] - ) - - /* - * Pipeline reporting - */ - GET_SOFTWARE_VERSIONS ( - ch_software_versions.map { it }.collect(), - params.modules['get_software_versions'] - ) - - OUTPUT_DOCUMENTATION ( - ch_output_docs, - ch_output_docs_images, - params.modules['output_documentation'] - ) - - /* - * MultiQC - */ - workflow_summary = Schema.params_mqc_summary(summary) - ch_workflow_summary = Channel.value(workflow_summary) - params.modules['multiqc'].publish_dir += "/$peakType" - MULTIQC ( - ch_multiqc_config, - ch_multiqc_custom_config.collect().ifEmpty([]), - GET_SOFTWARE_VERSIONS.out.yaml.collect(), - ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml'), - - FASTQC_TRIMGALORE.out.fastqc_zip.collect{it[1]}.ifEmpty([]), - FASTQC_TRIMGALORE.out.trim_log.collect{it[1]}.ifEmpty([]), - FASTQC_TRIMGALORE.out.trim_zip.collect{it[1]}.ifEmpty([]), - - MAP_BWA_MEM.out.stats.collect{it[1]}, - MAP_BWA_MEM.out.flagstat.collect{it[1]}, - MAP_BWA_MEM.out.idxstats.collect{it[1]}, - - MARK_DUPLICATES_PICARD.out.stats.collect{it[1]}.ifEmpty([]), - MARK_DUPLICATES_PICARD.out.flagstat.collect{it[1]}.ifEmpty([]), - MARK_DUPLICATES_PICARD.out.idxstats.collect{it[1]}.ifEmpty([]), - MARK_DUPLICATES_PICARD.out.metrics.collect{it[1]}.ifEmpty([]), - - BAM_CLEAN.out.stats.collect{it[1]}.ifEmpty([]), - BAM_CLEAN.out.flagstat.collect{it[1]}.ifEmpty([]), - BAM_CLEAN.out.idxstats.collect{it[1]}.ifEmpty([]), - PICARD_COLLECTMULTIPLEMETRICS.out.metrics.collect{it[1]}.ifEmpty([]), - - PRESEQ_LCEXTRAP.out.ccurve.collect{it[1]}.ifEmpty([]), - DEEPTOOLS_PLOTPROFILE.out.table.collect{it[1]}.ifEmpty([]), - DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect{it[1]}.ifEmpty([]), - PHANTOMPEAKQUALTOOLS.out.spp.collect{it[1]}.ifEmpty([]), - MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.nsc.collect{it[1]}.ifEmpty([]), - MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.rsc.collect{it[1]}.ifEmpty([]), - MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.correlation.collect{it[1]}.ifEmpty([]), - - MULTIQC_CUSTOM_PEAKS.out.count.collect{it[1]}.ifEmpty([]), - MULTIQC_CUSTOM_PEAKS.out.frip.collect{it[1]}.ifEmpty([]), - PLOT_HOMER_ANNOTATEPEAKS.out.tsv.collect().ifEmpty([]), - SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), - // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) - - params.modules['multiqc'] - ) + //ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta, params.modules['bwa_index'] ).index + + //BWA_INDEX ( ch_fasta, { args : "-a bwtsw", publish_dir: "genome/bwa_index" } ) + def file_map = [ann:'', bwt:'test'] + //println(file_map) + //println(file_map ?: null) + def index_options = [args: "-a bwtsw", publish_dir: "genome/bwa_index", publish_files: file_map] + //def index_options = [args: "-a bwtsw", publish_dir: "genome/bwa_index", publish_files: "test"] + BWA_INDEX ( ch_fasta, index_options ) + + // if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf, params.modules['gtf2bed'] ) } + // + // MAKE_GENOME_FILTER ( + // GET_CHROM_SIZES ( ch_fasta, params.modules['get_chrom_sizes'] ).sizes, + // ch_blacklist.ifEmpty([]), + // params.modules['make_genome_filter'] + // ) + // ch_software_versions = Channel.empty() + // ch_software_versions = ch_software_versions.mix(MAKE_GENOME_FILTER.out.version.first().ifEmpty(null)) + // + // /* + // * Read QC & trimming + // */ + // nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' + // params.modules['trimgalore'].args += nextseq + // FASTQC_TRIMGALORE ( + // INPUT_CHECK.out.reads, + // params.skip_fastqc, + // params.skip_trimming, + // params.modules['fastqc'], + // params.modules['trimgalore'] + // ) + // ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.fastqc_version.first().ifEmpty(null)) + // ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.trimgalore_version.first().ifEmpty(null)) + // + // /* + // * Map reads & BAM QC + // */ + // score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' + // params.modules['bwa_mem'].args += score + // MAP_BWA_MEM ( + // FASTQC_TRIMGALORE.out.reads, + // ch_index, + // ch_fasta, + // params.modules['bwa_mem'], + // params.modules['samtools_sort_lib'] + // ) + // ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.bwa_version.first()) + // ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.samtools_version.first().ifEmpty(null)) + // + // /* + // * Merge resequenced BAM files + // */ + // MAP_BWA_MEM + // .out + // .bam + // .map { + // meta, bam -> + // fmeta = meta.findAll { it.key != 'read_group' } + // fmeta.id = fmeta.id.split('_')[0..-2].join('_') + // [ fmeta, bam ] } + // .groupTuple(by: [0]) + // .map { it -> [ it[0], it[1].flatten() ] } + // .set { ch_sort_bam } + // + // PICARD_MERGESAMFILES ( + // ch_sort_bam, + // params.modules['picard_mergesamfiles'] + // ) + // ch_software_versions = ch_software_versions.mix(PICARD_MERGESAMFILES.out.version.first().ifEmpty(null)) + // + // /* + // * Mark duplicates & filter BAM files + // */ + // MARK_DUPLICATES_PICARD ( + // PICARD_MERGESAMFILES.out.bam, + // params.modules['picard_markduplicates'], + // params.modules['samtools_sort_merged_lib'] + // ) + // + // // Fix getting name sorted BAM here for PE/SE + // BAM_CLEAN ( + // MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), + // MAKE_GENOME_FILTER.out.bed.collect(), + // ch_bamtools_filter_se_config, + // ch_bamtools_filter_pe_config, + // params.modules['bam_filter'], + // params.modules['bam_remove_orphans'], + // params.modules['samtools_sort_filter'] + // ) + // ch_software_versions = ch_software_versions.mix(BAM_CLEAN.out.bamtools_version.first().ifEmpty(null)) + // + // /* + // * Post alignment QC + // */ + // PICARD_COLLECTMULTIPLEMETRICS ( + // BAM_CLEAN.out.bam, + // ch_fasta, + // params.modules['picard_collectmultiplemetrics'] + // ) + // + // PRESEQ_LCEXTRAP ( + // BAM_CLEAN.out.bam, + // params.modules['preseq_lcextrap'] + // ) + // ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) + // + // PHANTOMPEAKQUALTOOLS ( + // BAM_CLEAN.out.bam, + // params.modules['phantompeakqualtools'] + // ) + // ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null)) + // + // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( + // PHANTOMPEAKQUALTOOLS.out.spp.join(PHANTOMPEAKQUALTOOLS.out.rdata, by: [0]), + // ch_spp_nsc_header, + // ch_spp_rsc_header, + // ch_spp_correlation_header, + // params.modules['multiqc_custom_phantompeakqualtools'] + // ) + // + // /* + // * Coverage tracks + // */ + // BEDTOOLS_GENOMECOV ( + // BAM_CLEAN.out.bam.join(BAM_CLEAN.out.flagstat, by: [0]), + // params.modules['bedtools_genomecov'] + // ) + // + // UCSC_BEDRAPHTOBIGWIG ( + // BEDTOOLS_GENOMECOV.out.bedgraph, + // GET_CHROM_SIZES.out.sizes, + // params.modules['ucsc_bedgraphtobigwig'] + // ) + // ch_software_versions = ch_software_versions.mix(UCSC_BEDRAPHTOBIGWIG.out.version.first().ifEmpty(null)) + // + // /* + // * Coverage plots + // */ + // DEEPTOOLS_COMPUTEMATRIX ( + // UCSC_BEDRAPHTOBIGWIG.out.bigwig, + // ch_gene_bed, + // params.modules['deeptools_computematrix'] + // ) + // ch_software_versions = ch_software_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.version.first().ifEmpty(null)) + // + // DEEPTOOLS_PLOTPROFILE ( + // DEEPTOOLS_COMPUTEMATRIX.out.matrix, + // params.modules['deeptools_plotprofile'] + // ) + // + // DEEPTOOLS_PLOTHEATMAP ( + // DEEPTOOLS_COMPUTEMATRIX.out.matrix, + // params.modules['deeptools_plotheatmap'] + // ) + // + // /* + // * Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] + // */ + // BAM_CLEAN + // .out + // .bam + // .join ( BAM_CLEAN.out.bai, by: [0] ) + // .map { meta, bam, bai -> meta.control ? null : [ meta.id, [ bam ] , [ bai ] ] } + // .set { ch_control_bam_bai } + // + // BAM_CLEAN + // .out + // .bam + // .join ( BAM_CLEAN.out.bai, by: [0] ) + // .map { meta, bam, bai -> meta.control ? [ meta.control, meta, [ bam ], [ bai ] ] : null } + // .combine(ch_control_bam_bai, by: 0) + // .map { it -> [ it[1] , it[2] + it[4], it[3] + it[5] ] } + // .set { ch_ip_control_bam_bai } + // + // /* + // * plotFingerprint for IP and control together + // */ + // params.modules['deeptools_plotfingerprint'].args += " --numberOfSamples $params.fingerprint_bins" + // DEEPTOOLS_PLOTFINGERPRINT ( + // ch_ip_control_bam_bai, + // params.modules['deeptools_plotfingerprint'] + // ) + // + // peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' + // if (params.macs_gsize) { + // + // /* + // * Call peaks + // */ + // broad = params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}" + // pileup = params.save_macs_pileup ? '--bdg --SPMR' : '' + // fdr = params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '' + // pvalue = params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' + // params.modules['macs2_callpeak'].publish_dir += "/$peakType" + // params.modules['macs2_callpeak'].args += " $broad $pileup $fdr $pvalue" + // + // // Create channel: [ val(meta), ip_bam, control_bam ] + // ch_ip_control_bam_bai + // .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } + // .set { ch_ip_control_bam } + // + // MACS2_CALLPEAK ( + // ch_ip_control_bam, + // params.macs_gsize, + // params.modules['macs2_callpeak'] + // ) + // ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.version.first().ifEmpty(null)) + // + // ch_ip_control_bam + // .join(MACS2_CALLPEAK.out.peak, by: [0]) + // .map { it -> [ it[0], it[1], it[3] ] } + // .set { ch_ip_peak } + // FRIP_SCORE ( + // ch_ip_peak, + // params.modules['frip_score'] + // ) + // + // ch_ip_peak + // .join(FRIP_SCORE.out.txt, by: [0]) + // .map { it -> [ it[0], it[2], it[3] ] } + // .set { ch_ip_peak_frip } + // MULTIQC_CUSTOM_PEAKS ( + // ch_ip_peak_frip, + // ch_peak_count_header, + // ch_frip_score_header, + // params.modules['multiqc_custom_peaks'] + // ) + // + // params.modules['plot_macs2_qc'].publish_dir += "/$peakType/qc" + // PLOT_MACS2_QC ( + // MACS2_CALLPEAK.out.peak.collect{it[1]}, + // params.modules['plot_macs2_qc'] + // ) + // + // params.modules['homer_annotatepeaks_macs2'].publish_dir += "/$peakType" + // HOMER_ANNOTATEPEAKS_MACS2 ( + // MACS2_CALLPEAK.out.peak, + // ch_fasta, + // ch_gtf, + // params.modules['homer_annotatepeaks_macs2'] + // ) + // ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.version.first().ifEmpty(null)) + // + // params.modules['plot_homer_annotatepeaks'].publish_dir += "/$peakType/qc" + // PLOT_HOMER_ANNOTATEPEAKS ( + // HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, + // ch_peak_annotation_header, + // "_peaks.annotatePeaks.txt", + // params.modules['plot_homer_annotatepeaks'] + // ) + // + // // Create channel: [ meta , [ peaks ] ] + // // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] + // MACS2_CALLPEAK + // .out + // .peak + // .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } + // .groupTuple() + // .map { + // antibody, groups, peaks -> + // [ antibody, + // groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, + // peaks ] } + // .map { + // antibody, groups, peaks -> + // def meta = [:] + // meta.id = antibody + // meta.multiple_groups = groups.size() > 1 + // meta.replicates_exist = groups.max { groups.value }.value > 1 + // [ meta, peaks ] } + // .set { ch_antibody_peaks } + // + // params.modules['macs2_consensus'].publish_dir += "/$peakType/consensus" + // MACS2_CONSENSUS ( + // ch_antibody_peaks, + // params.modules['macs2_consensus'] + // ) + // + // params.modules['homer_annotatepeaks_consensus'].publish_dir += "/$peakType/consensus" + // HOMER_ANNOTATEPEAKS_CONSENSUS ( + // MACS2_CONSENSUS.out.bed, + // ch_fasta, + // ch_gtf, + // params.modules['homer_annotatepeaks_consensus'] + // ) + // // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt + // // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt + // + // // Create channel: [ val(meta), ip_bam ] + // MACS2_CONSENSUS + // .out + // .saf + // .map { meta, saf -> [ meta.id, meta, saf ] } + // .set { ch_ip_saf } + // + // ch_ip_control_bam + // .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } + // .combine(ch_ip_saf) + // .map { + // it -> + // fmeta = it[1] + // fmeta['replicates_exist'] = it[4]['replicates_exist'] + // fmeta['multiple_groups'] = it[4]['multiple_groups'] + // [ fmeta, it[2], it[5] ] } + // .set { ch_ip_bam } + // + // params.modules['subread_featurecounts'].publish_dir += "/$peakType/consensus" + // SUBREAD_FEATURECOUNTS ( + // ch_ip_bam, + // params.modules['subread_featurecounts'] + // ) + // ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) + // + // // + // // DESEQ2_FEATURECOUNTS ( + // // params.modules['deseq2_featurecounts'] + // // ) + // // ch_deseq2_pca_header = file("$baseDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) + // // ch_deseq2_clustering_header = file("$baseDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) + // + // } + // + // /* + // * Create IGV session + // */ + // IGV ( + // ch_fasta, + // UCSC_BEDRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), + // MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), + // MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), + // params.modules['ucsc_bedgraphtobigwig'], + // params.modules['macs2_callpeak'], + // params.modules['macs2_consensus'], + // params.modules['igv'] + // ) + // + // /* + // * Pipeline reporting + // */ + // GET_SOFTWARE_VERSIONS ( + // ch_software_versions.map { it }.collect(), + // params.modules['get_software_versions'] + // ) + // + // OUTPUT_DOCUMENTATION ( + // ch_output_docs, + // ch_output_docs_images, + // params.modules['output_documentation'] + // ) + // + // /* + // * MultiQC + // */ + // workflow_summary = Schema.params_mqc_summary(summary) + // ch_workflow_summary = Channel.value(workflow_summary) + // params.modules['multiqc'].publish_dir += "/$peakType" + // MULTIQC ( + // ch_multiqc_config, + // ch_multiqc_custom_config.collect().ifEmpty([]), + // GET_SOFTWARE_VERSIONS.out.yaml.collect(), + // ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml'), + // + // FASTQC_TRIMGALORE.out.fastqc_zip.collect{it[1]}.ifEmpty([]), + // FASTQC_TRIMGALORE.out.trim_log.collect{it[1]}.ifEmpty([]), + // FASTQC_TRIMGALORE.out.trim_zip.collect{it[1]}.ifEmpty([]), + // + // MAP_BWA_MEM.out.stats.collect{it[1]}, + // MAP_BWA_MEM.out.flagstat.collect{it[1]}, + // MAP_BWA_MEM.out.idxstats.collect{it[1]}, + // + // MARK_DUPLICATES_PICARD.out.stats.collect{it[1]}.ifEmpty([]), + // MARK_DUPLICATES_PICARD.out.flagstat.collect{it[1]}.ifEmpty([]), + // MARK_DUPLICATES_PICARD.out.idxstats.collect{it[1]}.ifEmpty([]), + // MARK_DUPLICATES_PICARD.out.metrics.collect{it[1]}.ifEmpty([]), + // + // BAM_CLEAN.out.stats.collect{it[1]}.ifEmpty([]), + // BAM_CLEAN.out.flagstat.collect{it[1]}.ifEmpty([]), + // BAM_CLEAN.out.idxstats.collect{it[1]}.ifEmpty([]), + // PICARD_COLLECTMULTIPLEMETRICS.out.metrics.collect{it[1]}.ifEmpty([]), + // + // PRESEQ_LCEXTRAP.out.ccurve.collect{it[1]}.ifEmpty([]), + // DEEPTOOLS_PLOTPROFILE.out.table.collect{it[1]}.ifEmpty([]), + // DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect{it[1]}.ifEmpty([]), + // PHANTOMPEAKQUALTOOLS.out.spp.collect{it[1]}.ifEmpty([]), + // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.nsc.collect{it[1]}.ifEmpty([]), + // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.rsc.collect{it[1]}.ifEmpty([]), + // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.correlation.collect{it[1]}.ifEmpty([]), + // + // MULTIQC_CUSTOM_PEAKS.out.count.collect{it[1]}.ifEmpty([]), + // MULTIQC_CUSTOM_PEAKS.out.frip.collect{it[1]}.ifEmpty([]), + // PLOT_HOMER_ANNOTATEPEAKS.out.tsv.collect().ifEmpty([]), + // SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), + // // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) + // + // params.modules['multiqc'] + // ) } //////////////////////////////////////////////////// diff --git a/modules/nf-core/software/bwa_index.nf b/modules/nf-core/software/bwa_index.nf index bade7c393..e7f455e0c 100644 --- a/modules/nf-core/software/bwa_index.nf +++ b/modules/nf-core/software/bwa_index.nf @@ -1,52 +1,20 @@ -def SOFTWARE = 'bwa' - -// Function to initialise default values and to generate a Groovy Map of module options -def init_options (Map args, String publish_dir) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.suffix = args.suffix ?: '' - options.publish_dir = args.publish_dir ? args.publish_dir : publish_dir - options.publish_files = args.publish_files ?: null - options.publish_by_id = args.publish_by_id ?: false - return options -} +// Import generic module functions +include { initOptions; saveFiles } from './functions' -// Function to publish module results - // if publish_files == null - all files are published - // if publish_files == Map [:] - no files are published - // if publish_files == Map [ext:path] - Only files that end with "ext" are published to "path" appended to output directory -def publish_options ( filename, publish_files ) { - if (publish_files instanceof Map) { - if (!publish_files.isEmpty()) { - if (!filename.endsWith('.version.txt')) { - filename - // Loop through extensions and paths here - } - } - } - else { - if (!filename.endsWith('.version.txt')) filename - } -} +def SOFTWARE = 'bwa' process BWA_INDEX { tag "$fasta" label 'process_high' - //if (module_options.publish_files) { - publishDir "${params.outdir}/${options.publish_dir}", - mode: params.publish_dir_mode, - saveAs: { filename -> publish_options( filename, module_options.publish_files ) } - //} + publishDir "${params.outdir}/${options.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "biocontainers/bwa:v0.7.17_cv1" //container "https://depot.galaxyproject.org/singularity/bwa:0.7.17--hed695b0_7" conda (params.conda ? "bioconda::bwa=0.7.17" : null) - //echo true - //cache false - input: path fasta val options @@ -56,10 +24,9 @@ process BWA_INDEX { path "*.version.txt", emit: version script: - def module_options = init_options(options, SOFTWARE) + def module_options = initOptions(options, SOFTWARE) """ - echo $module_options - bwa index $options.args $fasta + bwa index $module_options.args $fasta echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${SOFTWARE}.version.txt """ } From 40138f451bc2ca6f0d7b12b654002240223c946f Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 3 Aug 2020 16:15:30 +0100 Subject: [PATCH 118/538] Add general module functions --- modules/nf-core/software/functions.nf | 38 +++++++++++++++++++++++++++ 1 file changed, 38 insertions(+) create mode 100644 modules/nf-core/software/functions.nf diff --git a/modules/nf-core/software/functions.nf b/modules/nf-core/software/functions.nf new file mode 100644 index 000000000..40f226d00 --- /dev/null +++ b/modules/nf-core/software/functions.nf @@ -0,0 +1,38 @@ +/* + * Function to initialise default values and to generate a Groovy Map of module options + */ +def initOptions(Map args, String publish_dir) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ? args.publish_dir : publish_dir + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Function to save/publish module results + * if publish_files == null : All files are published + * if publish_files == Map [:] : No files are published + * if publish_files == Map [ext:path] : Only files that end with "ext" are published to "path" (appended to output directory) + */ +def saveFiles(filename, options, publish_dir) { + if (!filename.endsWith('.version.txt')) { + def publish_files = initOptions(options, publish_dir).publish_files + if (publish_files instanceof Map) { + for (ext in publish_files) { + if (filename.endsWith(ext.key)) { + if (ext.value) { + return "${ext.value}/$filename" + } else { + return filename + } + } + } + } else { + return filename + } + } +} From d46f07761e2fe6d4659e6d0f51b0def00e4116bb Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 3 Aug 2020 17:09:06 +0100 Subject: [PATCH 119/538] Update publishdir logic --- modules/nf-core/software/bwa_index.nf | 4 ++-- modules/nf-core/software/bwa_mem.nf | 15 ++++++++------- .../nf-core/software/deeptools_computematrix.nf | 13 +++++++------ .../software/deeptools_plotfingerprint.nf | 13 +++++++------ .../nf-core/software/deeptools_plotheatmap.nf | 13 +++++++------ .../nf-core/software/deeptools_plotprofile.nf | 13 +++++++------ modules/nf-core/software/fastqc.nf | 15 ++++++++------- modules/nf-core/software/homer_annotatepeaks.nf | 13 +++++++------ modules/nf-core/software/macs2_callpeak.nf | 16 +++++++--------- modules/nf-core/software/phantompeakqualtools.nf | 11 ++++++----- .../software/picard_collectmultiplemetrics.nf | 13 +++++++------ .../nf-core/software/picard_markduplicates.nf | 13 +++++++------ modules/nf-core/software/picard_mergesamfiles.nf | 13 +++++++------ modules/nf-core/software/preseq_lcextrap.nf | 8 ++++---- modules/nf-core/software/samtools_flagstat.nf | 8 ++++---- modules/nf-core/software/samtools_idxstats.nf | 8 ++++---- modules/nf-core/software/samtools_index.nf | 8 ++++---- modules/nf-core/software/samtools_sort.nf | 13 +++++++------ modules/nf-core/software/samtools_stats.nf | 8 ++++---- .../nf-core/software/subread_featurecounts.nf | 13 +++++++------ modules/nf-core/software/trimgalore.nf | 15 ++++++++------- .../nf-core/software/ucsc_bedgraphtobigwig.nf | 11 ++++++----- 22 files changed, 135 insertions(+), 122 deletions(-) diff --git a/modules/nf-core/software/bwa_index.nf b/modules/nf-core/software/bwa_index.nf index e7f455e0c..53371e411 100644 --- a/modules/nf-core/software/bwa_index.nf +++ b/modules/nf-core/software/bwa_index.nf @@ -24,9 +24,9 @@ process BWA_INDEX { path "*.version.txt", emit: version script: - def module_options = initOptions(options, SOFTWARE) + def ioptions = initOptions(options, SOFTWARE) """ - bwa index $module_options.args $fasta + bwa index $ioptions.args $fasta echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/bwa_mem.nf b/modules/nf-core/software/bwa_mem.nf index 8f4e826ba..1110f9f75 100644 --- a/modules/nf-core/software/bwa_mem.nf +++ b/modules/nf-core/software/bwa_mem.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'bwa' process BWA_MEM { @@ -5,10 +8,7 @@ process BWA_MEM { label 'process_high' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" //container "https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" @@ -26,16 +26,17 @@ process BWA_MEM { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" rg = meta.read_group ? "-R ${meta.read_group}" : "" """ bwa mem \\ - $options.args \\ + $ioptions.args \\ $rg \\ -t $task.cpus \\ $fasta \\ $reads \\ - | samtools view $options.args2 -@ $task.cpus -bS -o ${prefix}.bam - + | samtools view $ioptions.args2 -@ $task.cpus -bS -o ${prefix}.bam - echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${SOFTWARE}.version.txt """ diff --git a/modules/nf-core/software/deeptools_computematrix.nf b/modules/nf-core/software/deeptools_computematrix.nf index 895afeb21..f82752d5d 100644 --- a/modules/nf-core/software/deeptools_computematrix.nf +++ b/modules/nf-core/software/deeptools_computematrix.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'deeptools' process DEEPTOOLS_COMPUTEMATRIX { @@ -5,10 +8,7 @@ process DEEPTOOLS_COMPUTEMATRIX { label 'process_high' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" @@ -26,10 +26,11 @@ process DEEPTOOLS_COMPUTEMATRIX { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ computeMatrix \\ - $options.args \\ + $ioptions.args \\ --regionsFileName $bed \\ --scoreFileName $bigwig \\ --outFileName ${prefix}.computeMatrix.mat.gz \\ diff --git a/modules/nf-core/software/deeptools_plotfingerprint.nf b/modules/nf-core/software/deeptools_plotfingerprint.nf index 0b0663a51..2bf044a9d 100644 --- a/modules/nf-core/software/deeptools_plotfingerprint.nf +++ b/modules/nf-core/software/deeptools_plotfingerprint.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'deeptools' process DEEPTOOLS_PLOTFINGERPRINT { @@ -5,10 +8,7 @@ process DEEPTOOLS_PLOTFINGERPRINT { label 'process_high' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" @@ -26,11 +26,12 @@ process DEEPTOOLS_PLOTFINGERPRINT { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" extend = (meta.single_end && params.fragment_size > 0) ? "--extendReads ${params.fragment_size}" : '' """ plotFingerprint \\ - $options.args \\ + $ioptions.args \\ $extend \\ --bamfiles ${bams.join(' ')} \\ --plotFile ${prefix}.plotFingerprint.pdf \\ diff --git a/modules/nf-core/software/deeptools_plotheatmap.nf b/modules/nf-core/software/deeptools_plotheatmap.nf index 5ded02db2..da7762092 100644 --- a/modules/nf-core/software/deeptools_plotheatmap.nf +++ b/modules/nf-core/software/deeptools_plotheatmap.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'deeptools' process DEEPTOOLS_PLOTHEATMAP { @@ -5,10 +8,7 @@ process DEEPTOOLS_PLOTHEATMAP { label 'process_low' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" @@ -25,10 +25,11 @@ process DEEPTOOLS_PLOTHEATMAP { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ plotHeatmap \\ - $options.args \\ + $ioptions.args \\ --matrixFile $matrix \\ --outFileName ${prefix}.plotHeatmap.pdf \\ --outFileNameMatrix ${prefix}.plotHeatmap.mat.tab diff --git a/modules/nf-core/software/deeptools_plotprofile.nf b/modules/nf-core/software/deeptools_plotprofile.nf index 3932e0e66..b477b6758 100644 --- a/modules/nf-core/software/deeptools_plotprofile.nf +++ b/modules/nf-core/software/deeptools_plotprofile.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'deeptools' process DEEPTOOLS_PLOTPROFILE { @@ -5,10 +8,7 @@ process DEEPTOOLS_PLOTPROFILE { label 'process_low' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" @@ -25,10 +25,11 @@ process DEEPTOOLS_PLOTPROFILE { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ plotProfile \\ - $options.args \\ + $ioptions.args \\ --matrixFile $matrix \\ --outFileName ${prefix}.plotProfile.pdf \\ --outFileNameData ${prefix}.plotProfile.tab diff --git a/modules/nf-core/software/fastqc.nf b/modules/nf-core/software/fastqc.nf index 8d5f49825..d5db7b00b 100644 --- a/modules/nf-core/software/fastqc.nf +++ b/modules/nf-core/software/fastqc.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'fastqc' process FASTQC { @@ -5,10 +8,7 @@ process FASTQC { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/fastqc:0.11.9--0" //container "https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0" @@ -26,18 +26,19 @@ process FASTQC { script: // Add soft-links to original FastQs for consistent naming in pipeline - prefix = options.suffix ? "${meta.id}.${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}.${ioptions.suffix}" : "${meta.id}" if (meta.single_end) { """ [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz - fastqc $options.args --threads $task.cpus ${prefix}.fastq.gz + fastqc $ioptions.args --threads $task.cpus ${prefix}.fastq.gz fastqc --version | sed -e "s/FastQC v//g" > ${SOFTWARE}.version.txt """ } else { """ [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz - fastqc $options.args --threads $task.cpus ${prefix}_1.fastq.gz ${prefix}_2.fastq.gz + fastqc $ioptions.args --threads $task.cpus ${prefix}_1.fastq.gz ${prefix}_2.fastq.gz fastqc --version | sed -e "s/FastQC v//g" > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf index c65a9ea49..d501f5aab 100644 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ b/modules/nf-core/software/homer_annotatepeaks.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'homer' def VERSION = '4.11' @@ -6,10 +9,7 @@ process HOMER_ANNOTATEPEAKS { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/homer:4.11--pl526h9a982cc_2" //container "https://depot.galaxyproject.org/singularity/homer:4.11--pl526h9a982cc_2" @@ -27,12 +27,13 @@ process HOMER_ANNOTATEPEAKS { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ annotatePeaks.pl \\ $peak \\ $fasta \\ - $options.args \\ + $ioptions.args \\ -gtf $gtf \\ -cpu $task.cpus \\ > ${prefix}.annotatePeaks.txt diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf index 20e2a93f0..2cd311918 100644 --- a/modules/nf-core/software/macs2_callpeak.nf +++ b/modules/nf-core/software/macs2_callpeak.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'macs2' process MACS2_CALLPEAK { @@ -5,10 +8,7 @@ process MACS2_CALLPEAK { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/macs2:2.2.7.1--py37h516909a_0" //container "https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py37h516909a_0" @@ -29,13 +29,14 @@ process MACS2_CALLPEAK { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" format = meta.single_end ? 'BAM' : 'BAMPE' control = controlbam ? "--control $controlbam" : '' """ macs2 \\ callpeak \\ - $options.args \\ + $ioptions.args \\ --gsize $macs2_gsize \\ --format $format \\ --name $prefix \\ @@ -45,6 +46,3 @@ process MACS2_CALLPEAK { macs2 --version | sed -e "s/macs2 //g" > ${SOFTWARE}.version.txt """ } -// cat ${ip}_peaks.${PEAK_TYPE} | wc -l | awk -v OFS='\t' '{ print "${ip}", \$1 }' | cat $peak_count_header - > ${ip}_peaks.count_mqc.tsv -// -// find * -type f -name "*.${PEAK_TYPE}" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/"{}"\\t0,0,178" \\; > ${ip}_peaks.igv.txt diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf index beaf754b0..d3332cd13 100644 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ b/modules/nf-core/software/phantompeakqualtools.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'phantompeakqualtools' def VERSION = '1.2.2' @@ -6,10 +9,7 @@ process PHANTOMPEAKQUALTOOLS { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/phantompeakqualtools:1.2.2--0" //container "https://depot.galaxyproject.org/singularity/phantompeakqualtools:1.2.2--0" @@ -27,7 +27,8 @@ process PHANTOMPEAKQUALTOOLS { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ RUN_SPP=`which run_spp.R` Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus diff --git a/modules/nf-core/software/picard_collectmultiplemetrics.nf b/modules/nf-core/software/picard_collectmultiplemetrics.nf index 80e0eacc2..fd1661bc7 100644 --- a/modules/nf-core/software/picard_collectmultiplemetrics.nf +++ b/modules/nf-core/software/picard_collectmultiplemetrics.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'picard' process PICARD_COLLECTMULTIPLEMETRICS { @@ -5,10 +8,7 @@ process PICARD_COLLECTMULTIPLEMETRICS { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" @@ -26,7 +26,8 @@ process PICARD_COLLECTMULTIPLEMETRICS { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" def avail_mem = 3 if (!task.memory) { log.info '[Picard CollectMultipleMetrics] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' @@ -37,7 +38,7 @@ process PICARD_COLLECTMULTIPLEMETRICS { picard \\ -Xmx${avail_mem}g \\ CollectMultipleMetrics \\ - $options.args \\ + $ioptions.args \\ INPUT=$bam \\ OUTPUT=${prefix}.CollectMultipleMetrics \\ REFERENCE_SEQUENCE=$fasta diff --git a/modules/nf-core/software/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf index 13abdd901..9d01ab7f9 100644 --- a/modules/nf-core/software/picard_markduplicates.nf +++ b/modules/nf-core/software/picard_markduplicates.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'picard' process PICARD_MARKDUPLICATES { @@ -5,10 +8,7 @@ process PICARD_MARKDUPLICATES { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" @@ -25,7 +25,8 @@ process PICARD_MARKDUPLICATES { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" def avail_mem = 3 if (!task.memory) { log.info '[Picard MarkDuplicates] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' @@ -36,7 +37,7 @@ process PICARD_MARKDUPLICATES { picard \\ -Xmx${avail_mem}g \\ MarkDuplicates \\ - $options.args \\ + $ioptions.args \\ INPUT=$bam \\ OUTPUT=${prefix}.bam \\ METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt diff --git a/modules/nf-core/software/picard_mergesamfiles.nf b/modules/nf-core/software/picard_mergesamfiles.nf index 5e81b5a52..c02adb8a2 100644 --- a/modules/nf-core/software/picard_mergesamfiles.nf +++ b/modules/nf-core/software/picard_mergesamfiles.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'picard' process PICARD_MERGESAMFILES { @@ -5,10 +8,7 @@ process PICARD_MERGESAMFILES { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" @@ -24,7 +24,8 @@ process PICARD_MERGESAMFILES { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" bam_files = bams.sort() def avail_mem = 3 if (!task.memory) { @@ -37,7 +38,7 @@ process PICARD_MERGESAMFILES { picard \\ -Xmx${avail_mem}g \\ MergeSamFiles \\ - $options.args \\ + $ioptions.args \\ ${'INPUT='+bam_files.join(' INPUT=')} \\ OUTPUT=${prefix}.bam echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${SOFTWARE}.version.txt diff --git a/modules/nf-core/software/preseq_lcextrap.nf b/modules/nf-core/software/preseq_lcextrap.nf index b5189911d..2fbfc745b 100644 --- a/modules/nf-core/software/preseq_lcextrap.nf +++ b/modules/nf-core/software/preseq_lcextrap.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'preseq' process PRESEQ_LCEXTRAP { @@ -6,10 +9,7 @@ process PRESEQ_LCEXTRAP { label 'error_ignore' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/preseq:2.0.3--hf53bd2b_3" //container "https://depot.galaxyproject.org/singularity/preseq:2.0.3--hf53bd2b_3" diff --git a/modules/nf-core/software/samtools_flagstat.nf b/modules/nf-core/software/samtools_flagstat.nf index b7f066653..c277b9f40 100644 --- a/modules/nf-core/software/samtools_flagstat.nf +++ b/modules/nf-core/software/samtools_flagstat.nf @@ -1,13 +1,13 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'samtools' process SAMTOOLS_FLAGSTAT { tag "$meta.id" publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_idxstats.nf b/modules/nf-core/software/samtools_idxstats.nf index 2462c0a21..8caf272eb 100644 --- a/modules/nf-core/software/samtools_idxstats.nf +++ b/modules/nf-core/software/samtools_idxstats.nf @@ -1,13 +1,13 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'samtools' process SAMTOOLS_IDXSTATS { tag "$meta.id" publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_index.nf b/modules/nf-core/software/samtools_index.nf index 7baafd525..fb737e9ec 100644 --- a/modules/nf-core/software/samtools_index.nf +++ b/modules/nf-core/software/samtools_index.nf @@ -1,13 +1,13 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'samtools' process SAMTOOLS_INDEX { tag "$meta.id" publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_sort.nf b/modules/nf-core/software/samtools_sort.nf index 8e665bb17..577378bdf 100644 --- a/modules/nf-core/software/samtools_sort.nf +++ b/modules/nf-core/software/samtools_sort.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'samtools' process SAMTOOLS_SORT { @@ -5,10 +8,7 @@ process SAMTOOLS_SORT { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" @@ -24,9 +24,10 @@ process SAMTOOLS_SORT { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ - samtools sort $options.args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam + samtools sort $ioptions.args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${SOFTWARE}.version.txt """ } diff --git a/modules/nf-core/software/samtools_stats.nf b/modules/nf-core/software/samtools_stats.nf index 1a8d84d07..54d485ca4 100644 --- a/modules/nf-core/software/samtools_stats.nf +++ b/modules/nf-core/software/samtools_stats.nf @@ -1,13 +1,13 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'samtools' process SAMTOOLS_STATS { tag "$meta.id" publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/subread_featurecounts.nf b/modules/nf-core/software/subread_featurecounts.nf index 36d38da01..5d87630c8 100644 --- a/modules/nf-core/software/subread_featurecounts.nf +++ b/modules/nf-core/software/subread_featurecounts.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'subread' process SUBREAD_FEATURECOUNTS { @@ -5,10 +8,7 @@ process SUBREAD_FEATURECOUNTS { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" //container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" @@ -25,11 +25,12 @@ process SUBREAD_FEATURECOUNTS { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" pe = meta.single_end ? '' : '-p' """ featureCounts \\ - $options.args \\ + $ioptions.args \\ $pe \\ -T $task.cpus \\ -a $annotation \\ diff --git a/modules/nf-core/software/trimgalore.nf b/modules/nf-core/software/trimgalore.nf index 130bc90ee..8f538f4f4 100644 --- a/modules/nf-core/software/trimgalore.nf +++ b/modules/nf-core/software/trimgalore.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'trimgalore' process TRIMGALORE { @@ -5,10 +8,7 @@ process TRIMGALORE { label 'process_high' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/trim-galore:0.6.5--0" //container "https://depot.galaxyproject.org/singularity/trim-galore:0.6.5--0" @@ -45,12 +45,13 @@ process TRIMGALORE { tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' // Added soft-links to original fastqs for consistent naming in MultiQC - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" if (meta.single_end) { """ [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz trim_galore \\ - $options.args \\ + $ioptions.args \\ --cores $cores \\ --gzip \\ $c_r1 \\ @@ -63,7 +64,7 @@ process TRIMGALORE { [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz trim_galore \\ - $options.args \\ + $ioptions.args \\ --cores $cores \\ --paired \\ --gzip \\ diff --git a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf index 43b9b16ce..09863f2ae 100644 --- a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf +++ b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + def SOFTWARE = 'ucsc' def VERSION = '377' @@ -6,10 +9,7 @@ process UCSC_BEDRAPHTOBIGWIG { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } container "quay.io/biocontainers/ucsc-bedgraphtobigwig:377--h446ed27_1" //container "https://depot.galaxyproject.org/singularity/ucsc-bedgraphtobigwig:377--h446ed27_1" @@ -26,7 +26,8 @@ process UCSC_BEDRAPHTOBIGWIG { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, SOFTWARE) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ bedGraphToBigWig $bedgraph $sizes ${prefix}.bigWig echo $VERSION > ${SOFTWARE}.version.txt From d85e3064801e0fa273456a4d6d653fd654905478 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 3 Aug 2020 17:09:27 +0100 Subject: [PATCH 120/538] Update modules config --- conf/modules.config | 168 ++++++++++++++++++++++---------------------- 1 file changed, 84 insertions(+), 84 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 7131e68f4..f21bdca23 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -4,169 +4,169 @@ * ------------------------------------------------- * * Available keys to override module options: - * args = Additional arguments appended to command in module. - * args2 = Second set of arguments appended to command in module (multi-tool modules). - * publish_by_id = Publish results in separate folders by meta.id value. - * publish_dir = Directory to publish results. - * publish_files = Groovy map where key = "file_ext" and value = "directory" to only publish results - * for a particular file extension. The value of "directory" is appended to the standard - * "publish_dir" path as defined above. - * suffix = File name suffix for output files + * args = Additional arguments appended to command in module. + * args2 = Second set of arguments appended to command in module (multi-tool modules). + * publish_by_id = Publish results in separate folders by meta.id value. + * publish_dir = Directory to publish results. + * publish_files = Groovy map where key = "file_ext" and value = "directory" to only publish results + * for a particular file extension. The value of "directory" is appended to the standard + * "publish_dir" path as defined above. + * suffix = File name suffix for output files */ params { modules { 'samplesheet_check' { - publish_dir = "pipeline_info" + publish_dir = "pipeline_info" } 'fastqc' { - args = "--quiet" + args = "--quiet" } 'trimgalore' { - args = "--fastqc" + args = "--fastqc" } 'bwa_index' { - args = "-a bwtsw" - publish_dir = "genome/bwa_index" + args = "-a bwtsw" + publish_dir = "genome/bwa_index" } 'gtf2bed' { - publish_dir = "genome" + publish_dir = "genome" } 'make_genome_filter' { - publish_dir = "genome" + publish_dir = "genome" } 'get_chrom_sizes' { - publish_dir = "genome" + publish_dir = "genome" } 'bwa_mem' { - args = "-M" - args2 = "-h -F 0x0100 -O BAM" - publish_dir = "bwa/library" - suffix = ".Lb" + args = "-M" + args2 = "-h -F 0x0100 -O BAM" + publish_dir = "bwa/library" + suffix = ".Lb" } 'samtools_sort_lib' { - publish_dir = "bwa/library" - suffix = ".Lb.sorted" + publish_dir = "bwa/library" + suffix = ".Lb.sorted" } 'picard_mergesamfiles' { - args = "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.sorted" + args = "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.sorted" } 'picard_markduplicates' { - args = "ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.mkD.sorted" + args = "ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.mkD.sorted" } 'samtools_sort_merged_lib' { - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.mkD.sorted" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.mkD.sorted" } 'bam_filter' { - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.flT.sorted" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.flT.sorted" } 'bam_remove_orphans' { - args = "--only_fr_pairs" - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.clN" + args = "--only_fr_pairs" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.clN" } 'samtools_sort_filter' { - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.clN.sorted" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.clN.sorted" } 'picard_collectmultiplemetrics' { - args = "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" - publish_dir = "bwa/mergedLibrary/picard_metrics" - suffix = ".mLb.clN.sorted" + args = "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" + publish_dir = "bwa/mergedLibrary/picard_metrics" + suffix = ".mLb.clN.sorted" } 'preseq_lcextrap' { - args = "-verbose -bam -seed 1" - publish_dir = "bwa/mergedLibrary/preseq" - suffix = ".mLb.clN" + args = "-verbose -bam -seed 1" + publish_dir = "bwa/mergedLibrary/preseq" + suffix = ".mLb.clN" } 'phantompeakqualtools' { - publish_dir = "bwa/mergedLibrary/phantompeakqualtools" - suffix = ".mLb.clN" + publish_dir = "bwa/mergedLibrary/phantompeakqualtools" + suffix = ".mLb.clN" } 'multiqc_custom_phantompeakqualtools' { - publish_files = [:] + publish_files = [:] } 'bedtools_genomecov' { - publish_dir = "bwa/mergedLibrary/bigwig" - suffix = ".mLb.clN" + publish_dir = "bwa/mergedLibrary/bigwig" + suffix = ".mLb.clN" } 'ucsc_bedgraphtobigwig' { - publish_dir = "bwa/mergedLibrary/bigwig" - suffix = ".mLb.clN" + publish_dir = "bwa/mergedLibrary/bigwig" + suffix = ".mLb.clN" } 'deeptools_computematrix' { - args = "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels" - publish_dir = "bwa/mergedLibrary/deeptools" - suffix = ".mLb.clN" + args = "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels" + publish_dir = "bwa/mergedLibrary/deeptools" + suffix = ".mLb.clN" } 'deeptools_plotprofile' { - publish_dir = "bwa/mergedLibrary/deeptools" - suffix = ".mLb.clN" + publish_dir = "bwa/mergedLibrary/deeptools" + suffix = ".mLb.clN" } 'deeptools_plotheatmap' { - publish_dir = "bwa/mergedLibrary/deeptools" - suffix = ".mLb.clN" + publish_dir = "bwa/mergedLibrary/deeptools" + suffix = ".mLb.clN" } 'deeptools_plotfingerprint' { - args = "--skipZeros" - publish_dir = "bwa/mergedLibrary/deeptools" - suffix = ".mLb.clN" + args = "--skipZeros" + publish_dir = "bwa/mergedLibrary/deeptools" + suffix = ".mLb.clN" } 'macs2_callpeak' { - args = "--keep-dup all" - publish_dir = "bwa/mergedLibrary/macs2" + args = "--keep-dup all" + publish_dir = "bwa/mergedLibrary/macs2" } 'frip_score' { - args = "-bed -c -f 0.20" - publish_files = [:] + args = "-bed -c -f 0.20" + publish_files = [:] } 'multiqc_custom_peaks' { - publish_files = [:] + publish_files = [:] } 'plot_macs2_qc' { - args = "-o ./ -p macs2_peak" - publish_dir = "bwa/mergedLibrary/macs2" + args = "-o ./ -p macs2_peak" + publish_dir = "bwa/mergedLibrary/macs2" } 'homer_annotatepeaks_macs2' { - args = "-gid" - publish_dir = "bwa/mergedLibrary/macs2" - suffix = "_peaks" + args = "-gid" + publish_dir = "bwa/mergedLibrary/macs2" + suffix = "_peaks" } 'plot_homer_annotatepeaks' { - args = "-o ./ -p macs2_annotatePeaks" - publish_dir = "bwa/mergedLibrary/macs2" + args = "-o ./ -p macs2_annotatePeaks" + publish_dir = "bwa/mergedLibrary/macs2" } 'macs2_consensus' { - publish_dir = "bwa/mergedLibrary/macs2" - publish_by_id = true + publish_dir = "bwa/mergedLibrary/macs2" + publish_by_id = true } 'homer_annotatepeaks_consensus' { - args = "-gid" - publish_dir = "bwa/mergedLibrary/macs2" - publish_by_id = true, - suffix = ".consensus_peaks" + args = "-gid" + publish_dir = "bwa/mergedLibrary/macs2" + publish_by_id = true + suffix = ".consensus_peaks" } 'subread_featurecounts' { - args = "-F SAF -O --fracOverlap 0.2" - publish_dir = "bwa/mergedLibrary/macs2" + args = "-F SAF -O --fracOverlap 0.2" + publish_dir = "bwa/mergedLibrary/macs2" } 'deseq2_featurecounts' { - publish_dir = "bwa/mergedLibrary/macs2" + publish_dir = "bwa/mergedLibrary/macs2" } 'igv' { - publish_dir = "igv" + publish_dir = "igv" } 'get_software_versions' { - publish_dir = "pipeline_info" + publish_dir = "pipeline_info" } 'output_documentation' { - publish_dir = "pipeline_info" + publish_dir = "pipeline_info" } } } From 61507397d01b09f6b8b20f9b80e4769aaef6ddc5 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 3 Aug 2020 17:09:38 +0100 Subject: [PATCH 121/538] Comment out for testing --- main.nf | 10 +--------- 1 file changed, 1 insertion(+), 9 deletions(-) diff --git a/main.nf b/main.nf index c13a5fd8b..605c0f7d9 100755 --- a/main.nf +++ b/main.nf @@ -192,15 +192,7 @@ workflow { /* * Prepare genome files */ - //ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta, params.modules['bwa_index'] ).index - - //BWA_INDEX ( ch_fasta, { args : "-a bwtsw", publish_dir: "genome/bwa_index" } ) - def file_map = [ann:'', bwt:'test'] - //println(file_map) - //println(file_map ?: null) - def index_options = [args: "-a bwtsw", publish_dir: "genome/bwa_index", publish_files: file_map] - //def index_options = [args: "-a bwtsw", publish_dir: "genome/bwa_index", publish_files: "test"] - BWA_INDEX ( ch_fasta, index_options ) + ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta, params.modules['bwa_index'] ).index // if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf, params.modules['gtf2bed'] ) } // From 8c4a41fc83eec9485076a3983082f3658474dde3 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 3 Aug 2020 17:41:35 +0100 Subject: [PATCH 122/538] Use task.process --- main.nf | 10 +++++++++- modules/nf-core/software/bwa_index.nf | 9 ++++----- 2 files changed, 13 insertions(+), 6 deletions(-) diff --git a/main.nf b/main.nf index 605c0f7d9..c13a5fd8b 100755 --- a/main.nf +++ b/main.nf @@ -192,7 +192,15 @@ workflow { /* * Prepare genome files */ - ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta, params.modules['bwa_index'] ).index + //ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta, params.modules['bwa_index'] ).index + + //BWA_INDEX ( ch_fasta, { args : "-a bwtsw", publish_dir: "genome/bwa_index" } ) + def file_map = [ann:'', bwt:'test'] + //println(file_map) + //println(file_map ?: null) + def index_options = [args: "-a bwtsw", publish_dir: "genome/bwa_index", publish_files: file_map] + //def index_options = [args: "-a bwtsw", publish_dir: "genome/bwa_index", publish_files: "test"] + BWA_INDEX ( ch_fasta, index_options ) // if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf, params.modules['gtf2bed'] ) } // diff --git a/modules/nf-core/software/bwa_index.nf b/modules/nf-core/software/bwa_index.nf index 53371e411..c5a92e529 100644 --- a/modules/nf-core/software/bwa_index.nf +++ b/modules/nf-core/software/bwa_index.nf @@ -1,14 +1,12 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'bwa' - process BWA_INDEX { tag "$fasta" label 'process_high' publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "biocontainers/bwa:v0.7.17_cv1" //container "https://depot.galaxyproject.org/singularity/bwa:0.7.17--hed695b0_7" @@ -24,9 +22,10 @@ process BWA_INDEX { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) """ bwa index $ioptions.args $fasta - echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${SOFTWARE}.version.txt + echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${software}.version.txt """ } From 00f1f69e51f2d5a278f95550b970b773da0a402f Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 3 Aug 2020 18:05:29 +0100 Subject: [PATCH 123/538] Use task.process everywhere --- modules/nf-core/software/bwa_mem.nf | 9 ++++----- modules/nf-core/software/deeptools_computematrix.nf | 9 ++++----- .../nf-core/software/deeptools_plotfingerprint.nf | 11 +++++------ modules/nf-core/software/deeptools_plotheatmap.nf | 9 ++++----- modules/nf-core/software/deeptools_plotprofile.nf | 9 ++++----- modules/nf-core/software/fastqc.nf | 11 +++++------ modules/nf-core/software/homer_annotatepeaks.nf | 8 ++++---- modules/nf-core/software/macs2_callpeak.nf | 9 ++++----- modules/nf-core/software/phantompeakqualtools.nf | 8 ++++---- .../software/picard_collectmultiplemetrics.nf | 9 ++++----- modules/nf-core/software/picard_markduplicates.nf | 9 ++++----- modules/nf-core/software/picard_mergesamfiles.nf | 11 +++++------ modules/nf-core/software/preseq_lcextrap.nf | 12 ++++++------ modules/nf-core/software/samtools_flagstat.nf | 7 +++---- modules/nf-core/software/samtools_idxstats.nf | 7 +++---- modules/nf-core/software/samtools_index.nf | 7 +++---- modules/nf-core/software/samtools_sort.nf | 11 +++++------ modules/nf-core/software/samtools_stats.nf | 7 +++---- modules/nf-core/software/subread_featurecounts.nf | 11 +++++------ modules/nf-core/software/trimgalore.nf | 11 +++++------ modules/nf-core/software/ucsc_bedgraphtobigwig.nf | 8 ++++---- 21 files changed, 88 insertions(+), 105 deletions(-) diff --git a/modules/nf-core/software/bwa_mem.nf b/modules/nf-core/software/bwa_mem.nf index 1110f9f75..0a749e402 100644 --- a/modules/nf-core/software/bwa_mem.nf +++ b/modules/nf-core/software/bwa_mem.nf @@ -1,14 +1,12 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'bwa' - process BWA_MEM { tag "$meta.id" label 'process_high' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" //container "https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" @@ -26,7 +24,8 @@ process BWA_MEM { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" rg = meta.read_group ? "-R ${meta.read_group}" : "" """ @@ -38,6 +37,6 @@ process BWA_MEM { $reads \\ | samtools view $ioptions.args2 -@ $task.cpus -bS -o ${prefix}.bam - - echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${SOFTWARE}.version.txt + echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${software}.version.txt """ } diff --git a/modules/nf-core/software/deeptools_computematrix.nf b/modules/nf-core/software/deeptools_computematrix.nf index f82752d5d..86be86dec 100644 --- a/modules/nf-core/software/deeptools_computematrix.nf +++ b/modules/nf-core/software/deeptools_computematrix.nf @@ -1,14 +1,12 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'deeptools' - process DEEPTOOLS_COMPUTEMATRIX { tag "$meta.id" label 'process_high' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" @@ -26,7 +24,8 @@ process DEEPTOOLS_COMPUTEMATRIX { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ computeMatrix \\ @@ -37,6 +36,6 @@ process DEEPTOOLS_COMPUTEMATRIX { --outFileNameMatrix ${prefix}.computeMatrix.vals.mat.tab \\ --numberOfProcessors $task.cpus - computeMatrix --version | sed -e "s/computeMatrix //g" > ${SOFTWARE}.version.txt + computeMatrix --version | sed -e "s/computeMatrix //g" > ${software}.version.txt """ } diff --git a/modules/nf-core/software/deeptools_plotfingerprint.nf b/modules/nf-core/software/deeptools_plotfingerprint.nf index 2bf044a9d..9326dd586 100644 --- a/modules/nf-core/software/deeptools_plotfingerprint.nf +++ b/modules/nf-core/software/deeptools_plotfingerprint.nf @@ -1,15 +1,13 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'deeptools' - process DEEPTOOLS_PLOTFINGERPRINT { tag "$meta.id" label 'process_high' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } - + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } + container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" @@ -26,7 +24,8 @@ process DEEPTOOLS_PLOTFINGERPRINT { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" extend = (meta.single_end && params.fragment_size > 0) ? "--extendReads ${params.fragment_size}" : '' """ @@ -39,6 +38,6 @@ process DEEPTOOLS_PLOTFINGERPRINT { --outQualityMetrics ${prefix}.plotFingerprint.qcmetrics.txt \\ --numberOfProcessors $task.cpus - plotFingerprint --version | sed -e "s/plotFingerprint //g" > ${SOFTWARE}.version.txt + plotFingerprint --version | sed -e "s/plotFingerprint //g" > ${software}.version.txt """ } diff --git a/modules/nf-core/software/deeptools_plotheatmap.nf b/modules/nf-core/software/deeptools_plotheatmap.nf index da7762092..68dcfcc90 100644 --- a/modules/nf-core/software/deeptools_plotheatmap.nf +++ b/modules/nf-core/software/deeptools_plotheatmap.nf @@ -1,14 +1,12 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'deeptools' - process DEEPTOOLS_PLOTHEATMAP { tag "$meta.id" label 'process_low' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" @@ -25,7 +23,8 @@ process DEEPTOOLS_PLOTHEATMAP { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ plotHeatmap \\ @@ -34,6 +33,6 @@ process DEEPTOOLS_PLOTHEATMAP { --outFileName ${prefix}.plotHeatmap.pdf \\ --outFileNameMatrix ${prefix}.plotHeatmap.mat.tab - plotHeatmap --version | sed -e "s/plotHeatmap //g" > ${SOFTWARE}.version.txt + plotHeatmap --version | sed -e "s/plotHeatmap //g" > ${software}.version.txt """ } diff --git a/modules/nf-core/software/deeptools_plotprofile.nf b/modules/nf-core/software/deeptools_plotprofile.nf index b477b6758..457b55a38 100644 --- a/modules/nf-core/software/deeptools_plotprofile.nf +++ b/modules/nf-core/software/deeptools_plotprofile.nf @@ -1,14 +1,12 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'deeptools' - process DEEPTOOLS_PLOTPROFILE { tag "$meta.id" label 'process_low' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" @@ -25,7 +23,8 @@ process DEEPTOOLS_PLOTPROFILE { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ plotProfile \\ @@ -34,6 +33,6 @@ process DEEPTOOLS_PLOTPROFILE { --outFileName ${prefix}.plotProfile.pdf \\ --outFileNameData ${prefix}.plotProfile.tab - plotProfile --version | sed -e "s/plotProfile //g" > ${SOFTWARE}.version.txt + plotProfile --version | sed -e "s/plotProfile //g" > ${software}.version.txt """ } diff --git a/modules/nf-core/software/fastqc.nf b/modules/nf-core/software/fastqc.nf index d5db7b00b..e3c8f0d04 100644 --- a/modules/nf-core/software/fastqc.nf +++ b/modules/nf-core/software/fastqc.nf @@ -1,14 +1,12 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'fastqc' - process FASTQC { tag "$meta.id" label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.toLowerCase()) } container "quay.io/biocontainers/fastqc:0.11.9--0" //container "https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0" @@ -26,20 +24,21 @@ process FASTQC { script: // Add soft-links to original FastQs for consistent naming in pipeline - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}.${ioptions.suffix}" : "${meta.id}" if (meta.single_end) { """ [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz fastqc $ioptions.args --threads $task.cpus ${prefix}.fastq.gz - fastqc --version | sed -e "s/FastQC v//g" > ${SOFTWARE}.version.txt + fastqc --version | sed -e "s/FastQC v//g" > ${software}.version.txt """ } else { """ [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz fastqc $ioptions.args --threads $task.cpus ${prefix}_1.fastq.gz ${prefix}_2.fastq.gz - fastqc --version | sed -e "s/FastQC v//g" > ${SOFTWARE}.version.txt + fastqc --version | sed -e "s/FastQC v//g" > ${software}.version.txt """ } } diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf index d501f5aab..0697dac94 100644 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ b/modules/nf-core/software/homer_annotatepeaks.nf @@ -1,7 +1,6 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'homer' def VERSION = '4.11' process HOMER_ANNOTATEPEAKS { @@ -9,7 +8,7 @@ process HOMER_ANNOTATEPEAKS { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/homer:4.11--pl526h9a982cc_2" //container "https://depot.galaxyproject.org/singularity/homer:4.11--pl526h9a982cc_2" @@ -27,7 +26,8 @@ process HOMER_ANNOTATEPEAKS { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ annotatePeaks.pl \\ @@ -38,6 +38,6 @@ process HOMER_ANNOTATEPEAKS { -cpu $task.cpus \\ > ${prefix}.annotatePeaks.txt - echo $VERSION > ${SOFTWARE}.version.txt + echo $VERSION > ${software}.version.txt """ } diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf index 2cd311918..dcd89ea63 100644 --- a/modules/nf-core/software/macs2_callpeak.nf +++ b/modules/nf-core/software/macs2_callpeak.nf @@ -1,14 +1,12 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'macs2' - process MACS2_CALLPEAK { tag "$meta.id" label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/macs2:2.2.7.1--py37h516909a_0" //container "https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py37h516909a_0" @@ -29,7 +27,8 @@ process MACS2_CALLPEAK { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" format = meta.single_end ? 'BAM' : 'BAMPE' control = controlbam ? "--control $controlbam" : '' @@ -43,6 +42,6 @@ process MACS2_CALLPEAK { --treatment $ipbam \\ $control - macs2 --version | sed -e "s/macs2 //g" > ${SOFTWARE}.version.txt + macs2 --version | sed -e "s/macs2 //g" > ${software}.version.txt """ } diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf index d3332cd13..d3e9bee54 100644 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ b/modules/nf-core/software/phantompeakqualtools.nf @@ -1,7 +1,6 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'phantompeakqualtools' def VERSION = '1.2.2' process PHANTOMPEAKQUALTOOLS { @@ -9,7 +8,7 @@ process PHANTOMPEAKQUALTOOLS { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.toLowerCase()) } container "quay.io/biocontainers/phantompeakqualtools:1.2.2--0" //container "https://depot.galaxyproject.org/singularity/phantompeakqualtools:1.2.2--0" @@ -27,11 +26,12 @@ process PHANTOMPEAKQUALTOOLS { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ RUN_SPP=`which run_spp.R` Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus - echo $VERSION > ${SOFTWARE}.version.txt + echo $VERSION > ${software}.version.txt """ } diff --git a/modules/nf-core/software/picard_collectmultiplemetrics.nf b/modules/nf-core/software/picard_collectmultiplemetrics.nf index fd1661bc7..084dde433 100644 --- a/modules/nf-core/software/picard_collectmultiplemetrics.nf +++ b/modules/nf-core/software/picard_collectmultiplemetrics.nf @@ -1,14 +1,12 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'picard' - process PICARD_COLLECTMULTIPLEMETRICS { tag "$meta.id" label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" @@ -26,7 +24,8 @@ process PICARD_COLLECTMULTIPLEMETRICS { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" def avail_mem = 3 if (!task.memory) { @@ -43,6 +42,6 @@ process PICARD_COLLECTMULTIPLEMETRICS { OUTPUT=${prefix}.CollectMultipleMetrics \\ REFERENCE_SEQUENCE=$fasta - echo \$(picard CollectMultipleMetrics --version 2>&1) | awk -F' ' '{print \$NF}' > ${SOFTWARE}.version.txt + echo \$(picard CollectMultipleMetrics --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt """ } diff --git a/modules/nf-core/software/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf index 9d01ab7f9..deee9411f 100644 --- a/modules/nf-core/software/picard_markduplicates.nf +++ b/modules/nf-core/software/picard_markduplicates.nf @@ -1,14 +1,12 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'picard' - process PICARD_MARKDUPLICATES { tag "$meta.id" label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" @@ -25,7 +23,8 @@ process PICARD_MARKDUPLICATES { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" def avail_mem = 3 if (!task.memory) { @@ -42,6 +41,6 @@ process PICARD_MARKDUPLICATES { OUTPUT=${prefix}.bam \\ METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt - echo \$(picard MarkDuplicates --version 2>&1) | awk -F' ' '{print \$NF}' > ${SOFTWARE}.version.txt + echo \$(picard MarkDuplicates --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt """ } diff --git a/modules/nf-core/software/picard_mergesamfiles.nf b/modules/nf-core/software/picard_mergesamfiles.nf index c02adb8a2..78522731c 100644 --- a/modules/nf-core/software/picard_mergesamfiles.nf +++ b/modules/nf-core/software/picard_mergesamfiles.nf @@ -1,14 +1,12 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'picard' - process PICARD_MERGESAMFILES { tag "$meta.id" label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" @@ -24,7 +22,8 @@ process PICARD_MERGESAMFILES { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" bam_files = bams.sort() def avail_mem = 3 @@ -41,12 +40,12 @@ process PICARD_MERGESAMFILES { $ioptions.args \\ ${'INPUT='+bam_files.join(' INPUT=')} \\ OUTPUT=${prefix}.bam - echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${SOFTWARE}.version.txt + echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt """ } else { """ ln -s ${bam_files[0]} ${prefix}.bam - echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${SOFTWARE}.version.txt + echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt """ } } diff --git a/modules/nf-core/software/preseq_lcextrap.nf b/modules/nf-core/software/preseq_lcextrap.nf index 2fbfc745b..2fb445f7e 100644 --- a/modules/nf-core/software/preseq_lcextrap.nf +++ b/modules/nf-core/software/preseq_lcextrap.nf @@ -1,15 +1,13 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'preseq' - process PRESEQ_LCEXTRAP { tag "$meta.id" label 'process_medium' label 'error_ignore' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/preseq:2.0.3--hf53bd2b_3" //container "https://depot.galaxyproject.org/singularity/preseq:2.0.3--hf53bd2b_3" @@ -26,17 +24,19 @@ process PRESEQ_LCEXTRAP { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" pe = meta.single_end ? '' : '-pe' """ preseq \\ lc_extrap \\ - $options.args \\ + $ioptions.args \\ $pe \\ -output ${prefix}.ccurve.txt \\ $bam cp .command.err ${prefix}.command.log - echo \$(preseq 2>&1) | sed 's/^.*Version: //; s/Usage:.*\$//' > ${SOFTWARE}.version.txt + echo \$(preseq 2>&1) | sed 's/^.*Version: //; s/Usage:.*\$//' > ${software}.version.txt """ } diff --git a/modules/nf-core/software/samtools_flagstat.nf b/modules/nf-core/software/samtools_flagstat.nf index c277b9f40..349612b33 100644 --- a/modules/nf-core/software/samtools_flagstat.nf +++ b/modules/nf-core/software/samtools_flagstat.nf @@ -1,13 +1,11 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'samtools' - process SAMTOOLS_FLAGSTAT { tag "$meta.id" publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" @@ -23,8 +21,9 @@ process SAMTOOLS_FLAGSTAT { path "*.version.txt", emit: version script: + def software = task.process.tokenize('_')[0].toLowerCase() """ samtools flagstat $bam > ${bam}.flagstat - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${SOFTWARE}.version.txt + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt """ } diff --git a/modules/nf-core/software/samtools_idxstats.nf b/modules/nf-core/software/samtools_idxstats.nf index 8caf272eb..9eb578efd 100644 --- a/modules/nf-core/software/samtools_idxstats.nf +++ b/modules/nf-core/software/samtools_idxstats.nf @@ -1,13 +1,11 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'samtools' - process SAMTOOLS_IDXSTATS { tag "$meta.id" publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" @@ -23,8 +21,9 @@ process SAMTOOLS_IDXSTATS { path "*.version.txt", emit: version script: + def software = task.process.tokenize('_')[0].toLowerCase() """ samtools idxstats $bam > ${bam}.idxstats - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${SOFTWARE}.version.txt + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt """ } diff --git a/modules/nf-core/software/samtools_index.nf b/modules/nf-core/software/samtools_index.nf index fb737e9ec..95f28ebe2 100644 --- a/modules/nf-core/software/samtools_index.nf +++ b/modules/nf-core/software/samtools_index.nf @@ -1,13 +1,11 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'samtools' - process SAMTOOLS_INDEX { tag "$meta.id" publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" @@ -23,8 +21,9 @@ process SAMTOOLS_INDEX { path "*.version.txt", emit: version script: + def software = task.process.tokenize('_')[0].toLowerCase() """ samtools index $bam - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${SOFTWARE}.version.txt + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt """ } diff --git a/modules/nf-core/software/samtools_sort.nf b/modules/nf-core/software/samtools_sort.nf index 577378bdf..7aff6a57d 100644 --- a/modules/nf-core/software/samtools_sort.nf +++ b/modules/nf-core/software/samtools_sort.nf @@ -1,15 +1,13 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'samtools' - process SAMTOOLS_SORT { tag "$meta.id" label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } - + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" @@ -24,10 +22,11 @@ process SAMTOOLS_SORT { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ samtools sort $ioptions.args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${SOFTWARE}.version.txt + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt """ } diff --git a/modules/nf-core/software/samtools_stats.nf b/modules/nf-core/software/samtools_stats.nf index 54d485ca4..e30228e75 100644 --- a/modules/nf-core/software/samtools_stats.nf +++ b/modules/nf-core/software/samtools_stats.nf @@ -1,13 +1,11 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'samtools' - process SAMTOOLS_STATS { tag "$meta.id" publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" @@ -23,8 +21,9 @@ process SAMTOOLS_STATS { path "*.version.txt", emit: version script: + def software = task.process.tokenize('_')[0].toLowerCase() """ samtools stats $bam > ${bam}.stats - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${SOFTWARE}.version.txt + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt """ } diff --git a/modules/nf-core/software/subread_featurecounts.nf b/modules/nf-core/software/subread_featurecounts.nf index 5d87630c8..5104b5d94 100644 --- a/modules/nf-core/software/subread_featurecounts.nf +++ b/modules/nf-core/software/subread_featurecounts.nf @@ -1,15 +1,13 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'subread' - process SUBREAD_FEATURECOUNTS { tag "$meta.id" label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } - + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } + container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" //container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" @@ -25,7 +23,8 @@ process SUBREAD_FEATURECOUNTS { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" pe = meta.single_end ? '' : '-p' """ @@ -37,6 +36,6 @@ process SUBREAD_FEATURECOUNTS { -o ${prefix}.featureCounts.txt \\ ${bams.join(' ')} - echo \$(featureCounts -v 2>&1) | sed -e "s/featureCounts v//g" > ${SOFTWARE}.version.txt + echo \$(featureCounts -v 2>&1) | sed -e "s/featureCounts v//g" > ${software}.version.txt """ } diff --git a/modules/nf-core/software/trimgalore.nf b/modules/nf-core/software/trimgalore.nf index 8f538f4f4..e430ef738 100644 --- a/modules/nf-core/software/trimgalore.nf +++ b/modules/nf-core/software/trimgalore.nf @@ -1,14 +1,12 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'trimgalore' - process TRIMGALORE { tag "$meta.id" label 'process_high' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.toLowerCase()) } container "quay.io/biocontainers/trim-galore:0.6.5--0" //container "https://depot.galaxyproject.org/singularity/trim-galore:0.6.5--0" @@ -45,7 +43,8 @@ process TRIMGALORE { tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' // Added soft-links to original fastqs for consistent naming in MultiQC - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" if (meta.single_end) { """ @@ -57,7 +56,7 @@ process TRIMGALORE { $c_r1 \\ $tpc_r1 \\ ${prefix}.fastq.gz - echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//' > ${SOFTWARE}.version.txt + echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//' > ${software}.version.txt """ } else { """ @@ -74,7 +73,7 @@ process TRIMGALORE { $tpc_r2 \\ ${prefix}_1.fastq.gz \\ ${prefix}_2.fastq.gz - echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//' > ${SOFTWARE}.version.txt + echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//' > ${software}.version.txt """ } } diff --git a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf index 09863f2ae..6f5126e5e 100644 --- a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf +++ b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf @@ -1,7 +1,6 @@ // Import generic module functions include { initOptions; saveFiles } from './functions' -def SOFTWARE = 'ucsc' def VERSION = '377' process UCSC_BEDRAPHTOBIGWIG { @@ -9,7 +8,7 @@ process UCSC_BEDRAPHTOBIGWIG { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, SOFTWARE) } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/ucsc-bedgraphtobigwig:377--h446ed27_1" //container "https://depot.galaxyproject.org/singularity/ucsc-bedgraphtobigwig:377--h446ed27_1" @@ -26,10 +25,11 @@ process UCSC_BEDRAPHTOBIGWIG { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, SOFTWARE) + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ bedGraphToBigWig $bedgraph $sizes ${prefix}.bigWig - echo $VERSION > ${SOFTWARE}.version.txt + echo $VERSION > ${software}.version.txt """ } From e7eabcfa438644564b491b1d06e69b018ce558af Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 3 Aug 2020 18:37:56 +0100 Subject: [PATCH 124/538] Add in save files --- modules/local/process/bam_filter.nf | 11 ++++++----- modules/local/process/bam_remove_orphans.nf | 12 +++++++----- modules/local/process/bedtools_genomecov.nf | 14 +++++++------- modules/local/process/frip_score.nf | 14 +++++++------- modules/local/process/get_chrom_sizes.nf | 10 +++++----- modules/local/process/get_software_versions.nf | 12 ++++++------ modules/local/process/gtf2bed.nf | 7 ++++--- modules/local/process/igv.nf | 7 ++++--- modules/local/process/macs2_consensus.nf | 11 +++++++---- modules/local/process/make_genome_filter.nf | 12 ++++++------ modules/local/process/multiqc.nf | 11 ++++++----- modules/local/process/multiqc_custom_peaks.nf | 12 +++++++----- .../process/multiqc_custom_phantompeakqualtools.nf | 12 +++++++----- modules/local/process/output_documentation.nf | 7 ++++--- modules/local/process/plot_homer_annotatepeaks.nf | 11 +++++++---- modules/local/process/plot_macs2_qc.nf | 11 +++++++---- modules/local/process/samplesheet_check.nf | 7 ++++--- 17 files changed, 101 insertions(+), 80 deletions(-) diff --git a/modules/local/process/bam_filter.nf b/modules/local/process/bam_filter.nf index 7edfd3339..0d6ec5876 100644 --- a/modules/local/process/bam_filter.nf +++ b/modules/local/process/bam_filter.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + /* * Filter BAM file */ @@ -6,10 +9,7 @@ process BAM_FILTER { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, task.process.toLowerCase()) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -25,7 +25,8 @@ process BAM_FILTER { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, task.process.toLowerCase()) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" filter_params = meta.single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' dup_params = params.keep_dups ? '' : '-F 0x0400' multimap_params = params.keep_multi_map ? '' : '-q 1' diff --git a/modules/local/process/bam_remove_orphans.nf b/modules/local/process/bam_remove_orphans.nf index 65b30d241..f17f0d1fa 100644 --- a/modules/local/process/bam_remove_orphans.nf +++ b/modules/local/process/bam_remove_orphans.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + /* * Remove orphan reads from paired-end BAM file */ @@ -6,9 +9,7 @@ process BAM_REMOVE_ORPHANS { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else filename } + saveAs: { filename -> saveFiles(filename, options, task.process.toLowerCase()) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -20,11 +21,12 @@ process BAM_REMOVE_ORPHANS { tuple val(meta), path("${prefix}.bam"), emit: bam script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def ioptions = initOptions(options, task.process.toLowerCase()) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" if (!meta.single_end) { """ samtools sort -n -@ $task.cpus -o ${prefix}.name.sorted.bam -T ${prefix}.name.sorted $bam - bampe_rm_orphan.py ${prefix}.name.sorted.bam ${prefix}.bam $options.args + bampe_rm_orphan.py ${prefix}.name.sorted.bam ${prefix}.bam $ioptions.args """ } else { """ diff --git a/modules/local/process/bedtools_genomecov.nf b/modules/local/process/bedtools_genomecov.nf index 5e60e76e5..115902c9f 100644 --- a/modules/local/process/bedtools_genomecov.nf +++ b/modules/local/process/bedtools_genomecov.nf @@ -1,14 +1,12 @@ -def SOFTWARE = 'bedtools' +// Import generic module functions +include { initOptions; saveFiles } from './functions' process BEDTOOLS_GENOMECOV { tag "$meta.id" label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" @@ -25,7 +23,9 @@ process BEDTOOLS_GENOMECOV { path "*.version.txt", emit: version script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" pe = meta.single_end ? '' : '-pc' extend = (meta.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' """ @@ -41,6 +41,6 @@ process BEDTOOLS_GENOMECOV { $extend \\ | sort -T '.' -k1,1 -k2,2n > ${prefix}.bedGraph - bedtools --version | sed -e "s/bedtools v//g" > ${SOFTWARE}.version.txt + bedtools --version | sed -e "s/bedtools v//g" > ${software}.version.txt """ } diff --git a/modules/local/process/frip_score.nf b/modules/local/process/frip_score.nf index 5ec357456..d5e382d78 100644 --- a/modules/local/process/frip_score.nf +++ b/modules/local/process/frip_score.nf @@ -1,12 +1,12 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + process FRIP_SCORE { tag "$meta.id" label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -18,10 +18,10 @@ process FRIP_SCORE { tuple val(meta), path("*.txt"), emit: txt script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" - + def ioptions = initOptions(options, task.process.tokenize('_')[0].toLowerCase()) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ - READS_IN_PEAKS=\$(intersectBed -a $bam -b $peak $options.args | awk -F '\t' '{sum += \$NF} END {print sum}') + READS_IN_PEAKS=\$(intersectBed -a $bam -b $peak $ioptions.args | awk -F '\t' '{sum += \$NF} END {print sum}') samtools flagstat $bam > ${bam}.flagstat grep 'mapped (' ${bam}.flagstat | awk -v a="\$READS_IN_PEAKS" -v OFS='\t' '{print "${prefix}", a/\$1}' > ${prefix}.FRiP.txt """ diff --git a/modules/local/process/get_chrom_sizes.nf b/modules/local/process/get_chrom_sizes.nf index 9424b046e..a76e2cfdd 100644 --- a/modules/local/process/get_chrom_sizes.nf +++ b/modules/local/process/get_chrom_sizes.nf @@ -1,4 +1,5 @@ -def SOFTWARE = 'samtools' +// Import generic module functions +include { initOptions; saveFiles } from './functions' /* * Get chromosome sizes from a fasta file @@ -7,9 +8,7 @@ process GET_CHROM_SIZES { tag "$fasta" publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else filename } + saveAs: { filename -> saveFiles(filename, options, "genome") } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" @@ -26,9 +25,10 @@ process GET_CHROM_SIZES { path "*.version.txt", emit: version script: + def software = 'samtools' """ samtools faidx $fasta cut -f 1,2 ${fasta}.fai > ${fasta}.sizes - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${SOFTWARE}.version.txt + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt """ } diff --git a/modules/local/process/get_software_versions.nf b/modules/local/process/get_software_versions.nf index 3dff31d87..a097e9408 100644 --- a/modules/local/process/get_software_versions.nf +++ b/modules/local/process/get_software_versions.nf @@ -1,13 +1,13 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + /* * Parse software version numbers */ process GET_SOFTWARE_VERSIONS { - publishDir "${params.outdir}/${options.publish_dir}", - mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.yaml')) null - else filename } + publishDir "${params.outdir}/${options.publish_dir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename, options, "pipeline_info") } input: path versions diff --git a/modules/local/process/gtf2bed.nf b/modules/local/process/gtf2bed.nf index a10b57102..0f2533773 100644 --- a/modules/local/process/gtf2bed.nf +++ b/modules/local/process/gtf2bed.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + /* * Convert GTF file to BED format */ @@ -6,9 +9,7 @@ process GTF2BED { label 'process_low' publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else filename } + saveAs: { filename -> saveFiles(filename, options, "genome") } container "quay.io/biocontainers/perl:5.26.2" //container "https://depot.galaxyproject.org/singularity/perl:5.26.2" diff --git a/modules/local/process/igv.nf b/modules/local/process/igv.nf index f7c7bae9b..0e95f7062 100644 --- a/modules/local/process/igv.nf +++ b/modules/local/process/igv.nf @@ -1,12 +1,13 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + /* * Create IGV session file */ process IGV { publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else filename } + saveAs: { filename -> saveFiles(filename, options, task.process.toLowerCase()) } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/macs2_consensus.nf b/modules/local/process/macs2_consensus.nf index ed26a5a86..be6d85d23 100644 --- a/modules/local/process/macs2_consensus.nf +++ b/modules/local/process/macs2_consensus.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + /* * Consensus peaks across samples, create boolean filtering file, SAF file for featureCounts */ @@ -6,9 +9,7 @@ process MACS2_CONSENSUS { label 'process_long' publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else filename } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -25,7 +26,9 @@ process MACS2_CONSENSUS { script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ if (meta.multiple_groups || meta.replicates_exist) { - prefix = options.suffix ? "${meta.id}${options.suffix}.consensus_peaks" : "${meta.id}.consensus_peaks" + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}.consensus_peaks" : "${meta.id}.consensus_peaks" peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') diff --git a/modules/local/process/make_genome_filter.nf b/modules/local/process/make_genome_filter.nf index bc9b5a98f..215e88d8a 100644 --- a/modules/local/process/make_genome_filter.nf +++ b/modules/local/process/make_genome_filter.nf @@ -1,4 +1,5 @@ -def SOFTWARE = 'bedtools' +// Import generic module functions +include { initOptions; saveFiles } from './functions' /* * Prepare genome intervals for filtering by removing regions in blacklist file @@ -7,9 +8,7 @@ process MAKE_GENOME_FILTER { tag "$sizes" publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else filename } + saveAs: { filename -> saveFiles(filename, options, "genome") } container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" @@ -26,16 +25,17 @@ process MAKE_GENOME_FILTER { path "*.version.txt", emit: version script: + def software = 'bedtools' file_out = "${sizes.simpleName}.include_regions.bed" if (params.blacklist) { """ sortBed -i $blacklist -g $sizes | complementBed -i stdin -g $sizes > $file_out - bedtools --version | sed -e "s/bedtools v//g" > ${SOFTWARE}.version.txt + bedtools --version | sed -e "s/bedtools v//g" > ${software}.version.txt """ } else { """ awk '{print \$1, '0' , \$2}' OFS='\t' $sizes > $file_out - bedtools --version | sed -e "s/bedtools v//g" > ${SOFTWARE}.version.txt + bedtools --version | sed -e "s/bedtools v//g" > ${software}.version.txt """ } } diff --git a/modules/local/process/multiqc.nf b/modules/local/process/multiqc.nf index 15d64be86..395dd0c5e 100644 --- a/modules/local/process/multiqc.nf +++ b/modules/local/process/multiqc.nf @@ -1,4 +1,5 @@ -def SOFTWARE = 'multiqc' +// Import generic module functions +include { initOptions; saveFiles } from './functions' // Has the run name been specified by the user? // this has the bonus effect of catching both -name and --name @@ -11,9 +12,7 @@ process MULTIQC { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else filename } + saveAs: { filename -> saveFiles(filename, options, task.process.toLowerCase()) } container "quay.io/biocontainers/multiqc:1.9--pyh9f0ad1d_0" //container "https://depot.galaxyproject.org/singularity/multiqc:1.9--pyh9f0ad1d_0" @@ -66,10 +65,12 @@ process MULTIQC { path "*_data", emit: data script: + def software = task.process.toLowerCase() + def ioptions = initOptions(options, software) rtitle = custom_runName ? "--title \"$custom_runName\"" : '' rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' custom_config_file = params.multiqc_config ? "--config $mqc_custom_config" : '' """ - multiqc -f $options.args $rtitle $rfilename $custom_config_file . + multiqc -f $ioptions.args $rtitle $rfilename $custom_config_file . """ } diff --git a/modules/local/process/multiqc_custom_peaks.nf b/modules/local/process/multiqc_custom_peaks.nf index a6a918010..7c5d4bad2 100644 --- a/modules/local/process/multiqc_custom_peaks.nf +++ b/modules/local/process/multiqc_custom_peaks.nf @@ -1,11 +1,11 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + process MULTIQC_CUSTOM_PEAKS { tag "$meta.id" publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -20,7 +20,9 @@ process MULTIQC_CUSTOM_PEAKS { tuple val(meta), path("*.FRiP_mqc.tsv"), emit: frip script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ cat $peak | wc -l | awk -v OFS='\t' '{ print "${prefix}", \$1 }' | cat $peak_count_header - > ${prefix}.peak_count_mqc.tsv cat $frip_score_header $frip > ${prefix}.FRiP_mqc.tsv diff --git a/modules/local/process/multiqc_custom_phantompeakqualtools.nf b/modules/local/process/multiqc_custom_phantompeakqualtools.nf index 6b79fcc72..3dc7ef9be 100644 --- a/modules/local/process/multiqc_custom_phantompeakqualtools.nf +++ b/modules/local/process/multiqc_custom_phantompeakqualtools.nf @@ -1,11 +1,11 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { tag "$meta.id" publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else if (filename.endsWith('.version.txt')) null - else filename } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -22,7 +22,9 @@ process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { tuple val(meta), path("*.spp_correlation_mqc.tsv"), emit: correlation script: - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def software = task.process.tokenize('_')[0].toLowerCase() + def ioptions = initOptions(options, software) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ cp $correlation_header ${prefix}.spp_correlation_mqc.tsv Rscript -e "load('$rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}.spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" diff --git a/modules/local/process/output_documentation.nf b/modules/local/process/output_documentation.nf index 0f8cecd5c..80e18d14f 100644 --- a/modules/local/process/output_documentation.nf +++ b/modules/local/process/output_documentation.nf @@ -1,12 +1,13 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + /* * Output Markdown documentation to HTML */ process OUTPUT_DOCUMENTATION { publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else filename } + saveAs: { filename -> saveFiles(filename, options, "pipeline_info") } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/plot_homer_annotatepeaks.nf b/modules/local/process/plot_homer_annotatepeaks.nf index d4ec3f196..4d5665756 100644 --- a/modules/local/process/plot_homer_annotatepeaks.nf +++ b/modules/local/process/plot_homer_annotatepeaks.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + /* * Aggregated QC plots for peak-to-gene annotation */ @@ -5,9 +8,7 @@ process PLOT_HOMER_ANNOTATEPEAKS { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else filename } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[1].toLowerCase()) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -23,11 +24,13 @@ process PLOT_HOMER_ANNOTATEPEAKS { path '*.tsv', emit: tsv script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + def software = task.process.tokenize('_')[1].toLowerCase() + def ioptions = initOptions(options, software) """ plot_homer_annotatepeaks.r \\ -i ${annos.join(',')} \\ -s ${annos.join(',').replaceAll("${suffix}","")} \\ - $options.args + $ioptions.args find ./ -type f -name "*.txt" -exec cat {} \\; | cat $mqc_header - > annotatepeaks.summary_mqc.tsv """ diff --git a/modules/local/process/plot_macs2_qc.nf b/modules/local/process/plot_macs2_qc.nf index fe17c6b7f..9ecb4a944 100644 --- a/modules/local/process/plot_macs2_qc.nf +++ b/modules/local/process/plot_macs2_qc.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + /* * Aggregated QC plots for peaks */ @@ -5,9 +8,7 @@ process PLOT_MACS2_QC { label 'process_medium' publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else filename } + saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[1].toLowerCase()) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -20,11 +21,13 @@ process PLOT_MACS2_QC { path '*.pdf', emit: pdf script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + def software = task.process.tokenize('_')[1].toLowerCase() + def ioptions = initOptions(options, software) peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' """ plot_macs2_qc.r \\ -i ${peaks.join(',')} \\ -s ${peaks.join(',').replaceAll("_peaks.${peak_type}","")} \\ - $options.args + $ioptions.args """ } diff --git a/modules/local/process/samplesheet_check.nf b/modules/local/process/samplesheet_check.nf index 29d43e718..35c4e3bda 100644 --- a/modules/local/process/samplesheet_check.nf +++ b/modules/local/process/samplesheet_check.nf @@ -1,3 +1,6 @@ +// Import generic module functions +include { initOptions; saveFiles } from './functions' + /* * Reformat design file, check validitiy and create IP vs control mappings */ @@ -5,9 +8,7 @@ process SAMPLESHEET_CHECK { tag "$samplesheet" publishDir "${params.outdir}/${options.publish_dir}", mode: params.publish_dir_mode, - saveAs: { filename -> - if (options.publish_results == "none") null - else filename } + saveAs: { filename -> saveFiles(filename, options, "pipeline_info") } conda (params.conda ? "${baseDir}/environment.yml" : null) From bed40b335daf3a05f41818d84a8fd87788c1a136 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 3 Aug 2020 18:39:31 +0100 Subject: [PATCH 125/538] Update all modules --- conf/modules.config | 5 +--- main.nf | 10 +------- modules/local/process/functions.nf | 38 ++++++++++++++++++++++++++++++ 3 files changed, 40 insertions(+), 13 deletions(-) create mode 100644 modules/local/process/functions.nf diff --git a/conf/modules.config b/conf/modules.config index f21bdca23..af73d74a5 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -29,9 +29,6 @@ params { args = "-a bwtsw" publish_dir = "genome/bwa_index" } - 'gtf2bed' { - publish_dir = "genome" - } 'make_genome_filter' { publish_dir = "genome" } @@ -163,7 +160,7 @@ params { publish_dir = "igv" } 'get_software_versions' { - publish_dir = "pipeline_info" + publish_files = ['csv':''] } 'output_documentation' { publish_dir = "pipeline_info" diff --git a/main.nf b/main.nf index c13a5fd8b..605c0f7d9 100755 --- a/main.nf +++ b/main.nf @@ -192,15 +192,7 @@ workflow { /* * Prepare genome files */ - //ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta, params.modules['bwa_index'] ).index - - //BWA_INDEX ( ch_fasta, { args : "-a bwtsw", publish_dir: "genome/bwa_index" } ) - def file_map = [ann:'', bwt:'test'] - //println(file_map) - //println(file_map ?: null) - def index_options = [args: "-a bwtsw", publish_dir: "genome/bwa_index", publish_files: file_map] - //def index_options = [args: "-a bwtsw", publish_dir: "genome/bwa_index", publish_files: "test"] - BWA_INDEX ( ch_fasta, index_options ) + ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta, params.modules['bwa_index'] ).index // if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf, params.modules['gtf2bed'] ) } // diff --git a/modules/local/process/functions.nf b/modules/local/process/functions.nf new file mode 100644 index 000000000..40f226d00 --- /dev/null +++ b/modules/local/process/functions.nf @@ -0,0 +1,38 @@ +/* + * Function to initialise default values and to generate a Groovy Map of module options + */ +def initOptions(Map args, String publish_dir) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ? args.publish_dir : publish_dir + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Function to save/publish module results + * if publish_files == null : All files are published + * if publish_files == Map [:] : No files are published + * if publish_files == Map [ext:path] : Only files that end with "ext" are published to "path" (appended to output directory) + */ +def saveFiles(filename, options, publish_dir) { + if (!filename.endsWith('.version.txt')) { + def publish_files = initOptions(options, publish_dir).publish_files + if (publish_files instanceof Map) { + for (ext in publish_files) { + if (filename.endsWith(ext.key)) { + if (ext.value) { + return "${ext.value}/$filename" + } else { + return filename + } + } + } + } else { + return filename + } + } +} From cdb59d9e425cfd915a5061b1a189d1cbccbed728 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 3 Aug 2020 19:17:51 +0100 Subject: [PATCH 126/538] Get pipeline working from end-to-end again. Woohoooooo --- conf/modules.config | 30 +- main.nf | 774 ++++++++++++++++++++++---------------------- 2 files changed, 409 insertions(+), 395 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index af73d74a5..3d7125b92 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -4,14 +4,17 @@ * ------------------------------------------------- * * Available keys to override module options: - * args = Additional arguments appended to command in module. - * args2 = Second set of arguments appended to command in module (multi-tool modules). - * publish_by_id = Publish results in separate folders by meta.id value. - * publish_dir = Directory to publish results. - * publish_files = Groovy map where key = "file_ext" and value = "directory" to only publish results - * for a particular file extension. The value of "directory" is appended to the standard - * "publish_dir" path as defined above. - * suffix = File name suffix for output files + * MANDATORY + * publish_dir = Directory to publish results. + * + * OPTIONAL + * args = Additional arguments appended to command in module. + * args2 = Second set of arguments appended to command in module (multi-tool modules). + * publish_by_id = Publish results in separate folders by meta.id value. + * publish_files = Groovy map where key = "file_ext" and value = "directory" to only publish results + * for a particular file extension. The value of "directory" is appended to the standard + * "publish_dir" path as defined above. + * suffix = File name suffix for output files */ params { @@ -21,14 +24,19 @@ params { } 'fastqc' { args = "--quiet" + publish_dir = "fastqc" } 'trimgalore' { args = "--fastqc" + publish_dir = "trimgalore" } 'bwa_index' { args = "-a bwtsw" publish_dir = "genome/bwa_index" } + 'gtf2bed' { + publish_dir = "genome" + } 'make_genome_filter' { publish_dir = "genome" } @@ -87,6 +95,7 @@ params { suffix = ".mLb.clN" } 'multiqc_custom_phantompeakqualtools' { + publish_dir = "multiqc" publish_files = [:] } 'bedtools_genomecov' { @@ -121,9 +130,11 @@ params { } 'frip_score' { args = "-bed -c -f 0.20" + publish_dir = "frip" publish_files = [:] } 'multiqc_custom_peaks' { + publish_dir = "multiqc" publish_files = [:] } 'plot_macs2_qc' { @@ -165,5 +176,8 @@ params { 'output_documentation' { publish_dir = "pipeline_info" } + 'multiqc' { + publish_dir = "multiqc" + } } } diff --git a/main.nf b/main.nf index 605c0f7d9..caf6e30f6 100755 --- a/main.nf +++ b/main.nf @@ -194,393 +194,393 @@ workflow { */ ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta, params.modules['bwa_index'] ).index - // if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf, params.modules['gtf2bed'] ) } - // - // MAKE_GENOME_FILTER ( - // GET_CHROM_SIZES ( ch_fasta, params.modules['get_chrom_sizes'] ).sizes, - // ch_blacklist.ifEmpty([]), - // params.modules['make_genome_filter'] - // ) - // ch_software_versions = Channel.empty() - // ch_software_versions = ch_software_versions.mix(MAKE_GENOME_FILTER.out.version.first().ifEmpty(null)) - // - // /* - // * Read QC & trimming - // */ - // nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' - // params.modules['trimgalore'].args += nextseq - // FASTQC_TRIMGALORE ( - // INPUT_CHECK.out.reads, - // params.skip_fastqc, - // params.skip_trimming, - // params.modules['fastqc'], - // params.modules['trimgalore'] - // ) - // ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.fastqc_version.first().ifEmpty(null)) - // ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.trimgalore_version.first().ifEmpty(null)) - // - // /* - // * Map reads & BAM QC - // */ - // score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' - // params.modules['bwa_mem'].args += score - // MAP_BWA_MEM ( - // FASTQC_TRIMGALORE.out.reads, - // ch_index, - // ch_fasta, - // params.modules['bwa_mem'], - // params.modules['samtools_sort_lib'] - // ) - // ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.bwa_version.first()) - // ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.samtools_version.first().ifEmpty(null)) - // - // /* - // * Merge resequenced BAM files - // */ - // MAP_BWA_MEM - // .out - // .bam - // .map { - // meta, bam -> - // fmeta = meta.findAll { it.key != 'read_group' } - // fmeta.id = fmeta.id.split('_')[0..-2].join('_') - // [ fmeta, bam ] } - // .groupTuple(by: [0]) - // .map { it -> [ it[0], it[1].flatten() ] } - // .set { ch_sort_bam } - // - // PICARD_MERGESAMFILES ( - // ch_sort_bam, - // params.modules['picard_mergesamfiles'] - // ) - // ch_software_versions = ch_software_versions.mix(PICARD_MERGESAMFILES.out.version.first().ifEmpty(null)) - // - // /* - // * Mark duplicates & filter BAM files - // */ - // MARK_DUPLICATES_PICARD ( - // PICARD_MERGESAMFILES.out.bam, - // params.modules['picard_markduplicates'], - // params.modules['samtools_sort_merged_lib'] - // ) - // - // // Fix getting name sorted BAM here for PE/SE - // BAM_CLEAN ( - // MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), - // MAKE_GENOME_FILTER.out.bed.collect(), - // ch_bamtools_filter_se_config, - // ch_bamtools_filter_pe_config, - // params.modules['bam_filter'], - // params.modules['bam_remove_orphans'], - // params.modules['samtools_sort_filter'] - // ) - // ch_software_versions = ch_software_versions.mix(BAM_CLEAN.out.bamtools_version.first().ifEmpty(null)) - // - // /* - // * Post alignment QC - // */ - // PICARD_COLLECTMULTIPLEMETRICS ( - // BAM_CLEAN.out.bam, - // ch_fasta, - // params.modules['picard_collectmultiplemetrics'] - // ) - // - // PRESEQ_LCEXTRAP ( - // BAM_CLEAN.out.bam, - // params.modules['preseq_lcextrap'] - // ) - // ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) - // - // PHANTOMPEAKQUALTOOLS ( - // BAM_CLEAN.out.bam, - // params.modules['phantompeakqualtools'] - // ) - // ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null)) - // - // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( - // PHANTOMPEAKQUALTOOLS.out.spp.join(PHANTOMPEAKQUALTOOLS.out.rdata, by: [0]), - // ch_spp_nsc_header, - // ch_spp_rsc_header, - // ch_spp_correlation_header, - // params.modules['multiqc_custom_phantompeakqualtools'] - // ) - // - // /* - // * Coverage tracks - // */ - // BEDTOOLS_GENOMECOV ( - // BAM_CLEAN.out.bam.join(BAM_CLEAN.out.flagstat, by: [0]), - // params.modules['bedtools_genomecov'] - // ) - // - // UCSC_BEDRAPHTOBIGWIG ( - // BEDTOOLS_GENOMECOV.out.bedgraph, - // GET_CHROM_SIZES.out.sizes, - // params.modules['ucsc_bedgraphtobigwig'] - // ) - // ch_software_versions = ch_software_versions.mix(UCSC_BEDRAPHTOBIGWIG.out.version.first().ifEmpty(null)) - // - // /* - // * Coverage plots - // */ - // DEEPTOOLS_COMPUTEMATRIX ( - // UCSC_BEDRAPHTOBIGWIG.out.bigwig, - // ch_gene_bed, - // params.modules['deeptools_computematrix'] - // ) - // ch_software_versions = ch_software_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.version.first().ifEmpty(null)) - // - // DEEPTOOLS_PLOTPROFILE ( - // DEEPTOOLS_COMPUTEMATRIX.out.matrix, - // params.modules['deeptools_plotprofile'] - // ) - // - // DEEPTOOLS_PLOTHEATMAP ( - // DEEPTOOLS_COMPUTEMATRIX.out.matrix, - // params.modules['deeptools_plotheatmap'] - // ) - // - // /* - // * Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] - // */ - // BAM_CLEAN - // .out - // .bam - // .join ( BAM_CLEAN.out.bai, by: [0] ) - // .map { meta, bam, bai -> meta.control ? null : [ meta.id, [ bam ] , [ bai ] ] } - // .set { ch_control_bam_bai } - // - // BAM_CLEAN - // .out - // .bam - // .join ( BAM_CLEAN.out.bai, by: [0] ) - // .map { meta, bam, bai -> meta.control ? [ meta.control, meta, [ bam ], [ bai ] ] : null } - // .combine(ch_control_bam_bai, by: 0) - // .map { it -> [ it[1] , it[2] + it[4], it[3] + it[5] ] } - // .set { ch_ip_control_bam_bai } - // - // /* - // * plotFingerprint for IP and control together - // */ - // params.modules['deeptools_plotfingerprint'].args += " --numberOfSamples $params.fingerprint_bins" - // DEEPTOOLS_PLOTFINGERPRINT ( - // ch_ip_control_bam_bai, - // params.modules['deeptools_plotfingerprint'] - // ) - // - // peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' - // if (params.macs_gsize) { - // - // /* - // * Call peaks - // */ - // broad = params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}" - // pileup = params.save_macs_pileup ? '--bdg --SPMR' : '' - // fdr = params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '' - // pvalue = params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' - // params.modules['macs2_callpeak'].publish_dir += "/$peakType" - // params.modules['macs2_callpeak'].args += " $broad $pileup $fdr $pvalue" - // - // // Create channel: [ val(meta), ip_bam, control_bam ] - // ch_ip_control_bam_bai - // .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } - // .set { ch_ip_control_bam } - // - // MACS2_CALLPEAK ( - // ch_ip_control_bam, - // params.macs_gsize, - // params.modules['macs2_callpeak'] - // ) - // ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.version.first().ifEmpty(null)) - // - // ch_ip_control_bam - // .join(MACS2_CALLPEAK.out.peak, by: [0]) - // .map { it -> [ it[0], it[1], it[3] ] } - // .set { ch_ip_peak } - // FRIP_SCORE ( - // ch_ip_peak, - // params.modules['frip_score'] - // ) - // - // ch_ip_peak - // .join(FRIP_SCORE.out.txt, by: [0]) - // .map { it -> [ it[0], it[2], it[3] ] } - // .set { ch_ip_peak_frip } - // MULTIQC_CUSTOM_PEAKS ( - // ch_ip_peak_frip, - // ch_peak_count_header, - // ch_frip_score_header, - // params.modules['multiqc_custom_peaks'] - // ) - // - // params.modules['plot_macs2_qc'].publish_dir += "/$peakType/qc" - // PLOT_MACS2_QC ( - // MACS2_CALLPEAK.out.peak.collect{it[1]}, - // params.modules['plot_macs2_qc'] - // ) - // - // params.modules['homer_annotatepeaks_macs2'].publish_dir += "/$peakType" - // HOMER_ANNOTATEPEAKS_MACS2 ( - // MACS2_CALLPEAK.out.peak, - // ch_fasta, - // ch_gtf, - // params.modules['homer_annotatepeaks_macs2'] - // ) - // ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.version.first().ifEmpty(null)) - // - // params.modules['plot_homer_annotatepeaks'].publish_dir += "/$peakType/qc" - // PLOT_HOMER_ANNOTATEPEAKS ( - // HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, - // ch_peak_annotation_header, - // "_peaks.annotatePeaks.txt", - // params.modules['plot_homer_annotatepeaks'] - // ) - // - // // Create channel: [ meta , [ peaks ] ] - // // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] - // MACS2_CALLPEAK - // .out - // .peak - // .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } - // .groupTuple() - // .map { - // antibody, groups, peaks -> - // [ antibody, - // groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, - // peaks ] } - // .map { - // antibody, groups, peaks -> - // def meta = [:] - // meta.id = antibody - // meta.multiple_groups = groups.size() > 1 - // meta.replicates_exist = groups.max { groups.value }.value > 1 - // [ meta, peaks ] } - // .set { ch_antibody_peaks } - // - // params.modules['macs2_consensus'].publish_dir += "/$peakType/consensus" - // MACS2_CONSENSUS ( - // ch_antibody_peaks, - // params.modules['macs2_consensus'] - // ) - // - // params.modules['homer_annotatepeaks_consensus'].publish_dir += "/$peakType/consensus" - // HOMER_ANNOTATEPEAKS_CONSENSUS ( - // MACS2_CONSENSUS.out.bed, - // ch_fasta, - // ch_gtf, - // params.modules['homer_annotatepeaks_consensus'] - // ) - // // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt - // // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt - // - // // Create channel: [ val(meta), ip_bam ] - // MACS2_CONSENSUS - // .out - // .saf - // .map { meta, saf -> [ meta.id, meta, saf ] } - // .set { ch_ip_saf } - // - // ch_ip_control_bam - // .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } - // .combine(ch_ip_saf) - // .map { - // it -> - // fmeta = it[1] - // fmeta['replicates_exist'] = it[4]['replicates_exist'] - // fmeta['multiple_groups'] = it[4]['multiple_groups'] - // [ fmeta, it[2], it[5] ] } - // .set { ch_ip_bam } - // - // params.modules['subread_featurecounts'].publish_dir += "/$peakType/consensus" - // SUBREAD_FEATURECOUNTS ( - // ch_ip_bam, - // params.modules['subread_featurecounts'] - // ) - // ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) - // - // // - // // DESEQ2_FEATURECOUNTS ( - // // params.modules['deseq2_featurecounts'] - // // ) - // // ch_deseq2_pca_header = file("$baseDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) - // // ch_deseq2_clustering_header = file("$baseDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) - // - // } - // - // /* - // * Create IGV session - // */ - // IGV ( - // ch_fasta, - // UCSC_BEDRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), - // MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), - // MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), - // params.modules['ucsc_bedgraphtobigwig'], - // params.modules['macs2_callpeak'], - // params.modules['macs2_consensus'], - // params.modules['igv'] - // ) - // - // /* - // * Pipeline reporting - // */ - // GET_SOFTWARE_VERSIONS ( - // ch_software_versions.map { it }.collect(), - // params.modules['get_software_versions'] - // ) - // - // OUTPUT_DOCUMENTATION ( - // ch_output_docs, - // ch_output_docs_images, - // params.modules['output_documentation'] - // ) - // - // /* - // * MultiQC - // */ - // workflow_summary = Schema.params_mqc_summary(summary) - // ch_workflow_summary = Channel.value(workflow_summary) - // params.modules['multiqc'].publish_dir += "/$peakType" - // MULTIQC ( - // ch_multiqc_config, - // ch_multiqc_custom_config.collect().ifEmpty([]), - // GET_SOFTWARE_VERSIONS.out.yaml.collect(), - // ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml'), - // - // FASTQC_TRIMGALORE.out.fastqc_zip.collect{it[1]}.ifEmpty([]), - // FASTQC_TRIMGALORE.out.trim_log.collect{it[1]}.ifEmpty([]), - // FASTQC_TRIMGALORE.out.trim_zip.collect{it[1]}.ifEmpty([]), - // - // MAP_BWA_MEM.out.stats.collect{it[1]}, - // MAP_BWA_MEM.out.flagstat.collect{it[1]}, - // MAP_BWA_MEM.out.idxstats.collect{it[1]}, - // - // MARK_DUPLICATES_PICARD.out.stats.collect{it[1]}.ifEmpty([]), - // MARK_DUPLICATES_PICARD.out.flagstat.collect{it[1]}.ifEmpty([]), - // MARK_DUPLICATES_PICARD.out.idxstats.collect{it[1]}.ifEmpty([]), - // MARK_DUPLICATES_PICARD.out.metrics.collect{it[1]}.ifEmpty([]), - // - // BAM_CLEAN.out.stats.collect{it[1]}.ifEmpty([]), - // BAM_CLEAN.out.flagstat.collect{it[1]}.ifEmpty([]), - // BAM_CLEAN.out.idxstats.collect{it[1]}.ifEmpty([]), - // PICARD_COLLECTMULTIPLEMETRICS.out.metrics.collect{it[1]}.ifEmpty([]), - // - // PRESEQ_LCEXTRAP.out.ccurve.collect{it[1]}.ifEmpty([]), - // DEEPTOOLS_PLOTPROFILE.out.table.collect{it[1]}.ifEmpty([]), - // DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect{it[1]}.ifEmpty([]), - // PHANTOMPEAKQUALTOOLS.out.spp.collect{it[1]}.ifEmpty([]), - // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.nsc.collect{it[1]}.ifEmpty([]), - // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.rsc.collect{it[1]}.ifEmpty([]), - // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.correlation.collect{it[1]}.ifEmpty([]), - // - // MULTIQC_CUSTOM_PEAKS.out.count.collect{it[1]}.ifEmpty([]), - // MULTIQC_CUSTOM_PEAKS.out.frip.collect{it[1]}.ifEmpty([]), - // PLOT_HOMER_ANNOTATEPEAKS.out.tsv.collect().ifEmpty([]), - // SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), - // // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) - // - // params.modules['multiqc'] - // ) + if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf, params.modules['gtf2bed'] ) } + + MAKE_GENOME_FILTER ( + GET_CHROM_SIZES ( ch_fasta, params.modules['get_chrom_sizes'] ).sizes, + ch_blacklist.ifEmpty([]), + params.modules['make_genome_filter'] + ) + ch_software_versions = Channel.empty() + ch_software_versions = ch_software_versions.mix(MAKE_GENOME_FILTER.out.version.first().ifEmpty(null)) + + /* + * Read QC & trimming + */ + nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' + params.modules['trimgalore'].args += nextseq + FASTQC_TRIMGALORE ( + INPUT_CHECK.out.reads, + params.skip_fastqc, + params.skip_trimming, + params.modules['fastqc'], + params.modules['trimgalore'] + ) + ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.fastqc_version.first().ifEmpty(null)) + ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.trimgalore_version.first().ifEmpty(null)) + + /* + * Map reads & BAM QC + */ + score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' + params.modules['bwa_mem'].args += score + MAP_BWA_MEM ( + FASTQC_TRIMGALORE.out.reads, + ch_index, + ch_fasta, + params.modules['bwa_mem'], + params.modules['samtools_sort_lib'] + ) + ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.bwa_version.first()) + ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.samtools_version.first().ifEmpty(null)) + + /* + * Merge resequenced BAM files + */ + MAP_BWA_MEM + .out + .bam + .map { + meta, bam -> + fmeta = meta.findAll { it.key != 'read_group' } + fmeta.id = fmeta.id.split('_')[0..-2].join('_') + [ fmeta, bam ] } + .groupTuple(by: [0]) + .map { it -> [ it[0], it[1].flatten() ] } + .set { ch_sort_bam } + + PICARD_MERGESAMFILES ( + ch_sort_bam, + params.modules['picard_mergesamfiles'] + ) + ch_software_versions = ch_software_versions.mix(PICARD_MERGESAMFILES.out.version.first().ifEmpty(null)) + + /* + * Mark duplicates & filter BAM files + */ + MARK_DUPLICATES_PICARD ( + PICARD_MERGESAMFILES.out.bam, + params.modules['picard_markduplicates'], + params.modules['samtools_sort_merged_lib'] + ) + + // Fix getting name sorted BAM here for PE/SE + BAM_CLEAN ( + MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), + MAKE_GENOME_FILTER.out.bed.collect(), + ch_bamtools_filter_se_config, + ch_bamtools_filter_pe_config, + params.modules['bam_filter'], + params.modules['bam_remove_orphans'], + params.modules['samtools_sort_filter'] + ) + ch_software_versions = ch_software_versions.mix(BAM_CLEAN.out.bamtools_version.first().ifEmpty(null)) + + /* + * Post alignment QC + */ + PICARD_COLLECTMULTIPLEMETRICS ( + BAM_CLEAN.out.bam, + ch_fasta, + params.modules['picard_collectmultiplemetrics'] + ) + + PRESEQ_LCEXTRAP ( + BAM_CLEAN.out.bam, + params.modules['preseq_lcextrap'] + ) + ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) + + PHANTOMPEAKQUALTOOLS ( + BAM_CLEAN.out.bam, + params.modules['phantompeakqualtools'] + ) + ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null)) + + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( + PHANTOMPEAKQUALTOOLS.out.spp.join(PHANTOMPEAKQUALTOOLS.out.rdata, by: [0]), + ch_spp_nsc_header, + ch_spp_rsc_header, + ch_spp_correlation_header, + params.modules['multiqc_custom_phantompeakqualtools'] + ) + + /* + * Coverage tracks + */ + BEDTOOLS_GENOMECOV ( + BAM_CLEAN.out.bam.join(BAM_CLEAN.out.flagstat, by: [0]), + params.modules['bedtools_genomecov'] + ) + + UCSC_BEDRAPHTOBIGWIG ( + BEDTOOLS_GENOMECOV.out.bedgraph, + GET_CHROM_SIZES.out.sizes, + params.modules['ucsc_bedgraphtobigwig'] + ) + ch_software_versions = ch_software_versions.mix(UCSC_BEDRAPHTOBIGWIG.out.version.first().ifEmpty(null)) + + /* + * Coverage plots + */ + DEEPTOOLS_COMPUTEMATRIX ( + UCSC_BEDRAPHTOBIGWIG.out.bigwig, + ch_gene_bed, + params.modules['deeptools_computematrix'] + ) + ch_software_versions = ch_software_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.version.first().ifEmpty(null)) + + DEEPTOOLS_PLOTPROFILE ( + DEEPTOOLS_COMPUTEMATRIX.out.matrix, + params.modules['deeptools_plotprofile'] + ) + + DEEPTOOLS_PLOTHEATMAP ( + DEEPTOOLS_COMPUTEMATRIX.out.matrix, + params.modules['deeptools_plotheatmap'] + ) + + /* + * Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] + */ + BAM_CLEAN + .out + .bam + .join ( BAM_CLEAN.out.bai, by: [0] ) + .map { meta, bam, bai -> meta.control ? null : [ meta.id, [ bam ] , [ bai ] ] } + .set { ch_control_bam_bai } + + BAM_CLEAN + .out + .bam + .join ( BAM_CLEAN.out.bai, by: [0] ) + .map { meta, bam, bai -> meta.control ? [ meta.control, meta, [ bam ], [ bai ] ] : null } + .combine(ch_control_bam_bai, by: 0) + .map { it -> [ it[1] , it[2] + it[4], it[3] + it[5] ] } + .set { ch_ip_control_bam_bai } + + /* + * plotFingerprint for IP and control together + */ + params.modules['deeptools_plotfingerprint'].args += " --numberOfSamples $params.fingerprint_bins" + DEEPTOOLS_PLOTFINGERPRINT ( + ch_ip_control_bam_bai, + params.modules['deeptools_plotfingerprint'] + ) + + peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' + if (params.macs_gsize) { + + /* + * Call peaks + */ + broad = params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}" + pileup = params.save_macs_pileup ? '--bdg --SPMR' : '' + fdr = params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '' + pvalue = params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' + params.modules['macs2_callpeak'].publish_dir += "/$peakType" + params.modules['macs2_callpeak'].args += " $broad $pileup $fdr $pvalue" + + // Create channel: [ val(meta), ip_bam, control_bam ] + ch_ip_control_bam_bai + .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } + .set { ch_ip_control_bam } + + MACS2_CALLPEAK ( + ch_ip_control_bam, + params.macs_gsize, + params.modules['macs2_callpeak'] + ) + ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.version.first().ifEmpty(null)) + + ch_ip_control_bam + .join(MACS2_CALLPEAK.out.peak, by: [0]) + .map { it -> [ it[0], it[1], it[3] ] } + .set { ch_ip_peak } + FRIP_SCORE ( + ch_ip_peak, + params.modules['frip_score'] + ) + + ch_ip_peak + .join(FRIP_SCORE.out.txt, by: [0]) + .map { it -> [ it[0], it[2], it[3] ] } + .set { ch_ip_peak_frip } + MULTIQC_CUSTOM_PEAKS ( + ch_ip_peak_frip, + ch_peak_count_header, + ch_frip_score_header, + params.modules['multiqc_custom_peaks'] + ) + + params.modules['plot_macs2_qc'].publish_dir += "/$peakType/qc" + PLOT_MACS2_QC ( + MACS2_CALLPEAK.out.peak.collect{it[1]}, + params.modules['plot_macs2_qc'] + ) + + params.modules['homer_annotatepeaks_macs2'].publish_dir += "/$peakType" + HOMER_ANNOTATEPEAKS_MACS2 ( + MACS2_CALLPEAK.out.peak, + ch_fasta, + ch_gtf, + params.modules['homer_annotatepeaks_macs2'] + ) + ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.version.first().ifEmpty(null)) + + params.modules['plot_homer_annotatepeaks'].publish_dir += "/$peakType/qc" + PLOT_HOMER_ANNOTATEPEAKS ( + HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, + ch_peak_annotation_header, + "_peaks.annotatePeaks.txt", + params.modules['plot_homer_annotatepeaks'] + ) + + // Create channel: [ meta , [ peaks ] ] + // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] + MACS2_CALLPEAK + .out + .peak + .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } + .groupTuple() + .map { + antibody, groups, peaks -> + [ antibody, + groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, + peaks ] } + .map { + antibody, groups, peaks -> + def meta = [:] + meta.id = antibody + meta.multiple_groups = groups.size() > 1 + meta.replicates_exist = groups.max { groups.value }.value > 1 + [ meta, peaks ] } + .set { ch_antibody_peaks } + + params.modules['macs2_consensus'].publish_dir += "/$peakType/consensus" + MACS2_CONSENSUS ( + ch_antibody_peaks, + params.modules['macs2_consensus'] + ) + + params.modules['homer_annotatepeaks_consensus'].publish_dir += "/$peakType/consensus" + HOMER_ANNOTATEPEAKS_CONSENSUS ( + MACS2_CONSENSUS.out.bed, + ch_fasta, + ch_gtf, + params.modules['homer_annotatepeaks_consensus'] + ) + // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt + // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt + + // Create channel: [ val(meta), ip_bam ] + MACS2_CONSENSUS + .out + .saf + .map { meta, saf -> [ meta.id, meta, saf ] } + .set { ch_ip_saf } + + ch_ip_control_bam + .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } + .combine(ch_ip_saf) + .map { + it -> + fmeta = it[1] + fmeta['replicates_exist'] = it[4]['replicates_exist'] + fmeta['multiple_groups'] = it[4]['multiple_groups'] + [ fmeta, it[2], it[5] ] } + .set { ch_ip_bam } + + params.modules['subread_featurecounts'].publish_dir += "/$peakType/consensus" + SUBREAD_FEATURECOUNTS ( + ch_ip_bam, + params.modules['subread_featurecounts'] + ) + ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) + + // + // DESEQ2_FEATURECOUNTS ( + // params.modules['deseq2_featurecounts'] + // ) + // ch_deseq2_pca_header = file("$baseDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) + // ch_deseq2_clustering_header = file("$baseDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) + + } + + /* + * Create IGV session + */ + IGV ( + ch_fasta, + UCSC_BEDRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), + MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), + MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), + params.modules['ucsc_bedgraphtobigwig'], + params.modules['macs2_callpeak'], + params.modules['macs2_consensus'], + params.modules['igv'] + ) + + /* + * Pipeline reporting + */ + GET_SOFTWARE_VERSIONS ( + ch_software_versions.map { it }.collect(), + params.modules['get_software_versions'] + ) + + OUTPUT_DOCUMENTATION ( + ch_output_docs, + ch_output_docs_images, + params.modules['output_documentation'] + ) + + /* + * MultiQC + */ + workflow_summary = Schema.params_mqc_summary(summary) + ch_workflow_summary = Channel.value(workflow_summary) + params.modules['multiqc'].publish_dir += "/$peakType" + MULTIQC ( + ch_multiqc_config, + ch_multiqc_custom_config.collect().ifEmpty([]), + GET_SOFTWARE_VERSIONS.out.yaml.collect(), + ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml'), + + FASTQC_TRIMGALORE.out.fastqc_zip.collect{it[1]}.ifEmpty([]), + FASTQC_TRIMGALORE.out.trim_log.collect{it[1]}.ifEmpty([]), + FASTQC_TRIMGALORE.out.trim_zip.collect{it[1]}.ifEmpty([]), + + MAP_BWA_MEM.out.stats.collect{it[1]}, + MAP_BWA_MEM.out.flagstat.collect{it[1]}, + MAP_BWA_MEM.out.idxstats.collect{it[1]}, + + MARK_DUPLICATES_PICARD.out.stats.collect{it[1]}.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.flagstat.collect{it[1]}.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.idxstats.collect{it[1]}.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.metrics.collect{it[1]}.ifEmpty([]), + + BAM_CLEAN.out.stats.collect{it[1]}.ifEmpty([]), + BAM_CLEAN.out.flagstat.collect{it[1]}.ifEmpty([]), + BAM_CLEAN.out.idxstats.collect{it[1]}.ifEmpty([]), + PICARD_COLLECTMULTIPLEMETRICS.out.metrics.collect{it[1]}.ifEmpty([]), + + PRESEQ_LCEXTRAP.out.ccurve.collect{it[1]}.ifEmpty([]), + DEEPTOOLS_PLOTPROFILE.out.table.collect{it[1]}.ifEmpty([]), + DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect{it[1]}.ifEmpty([]), + PHANTOMPEAKQUALTOOLS.out.spp.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.nsc.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.rsc.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.correlation.collect{it[1]}.ifEmpty([]), + + MULTIQC_CUSTOM_PEAKS.out.count.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PEAKS.out.frip.collect{it[1]}.ifEmpty([]), + PLOT_HOMER_ANNOTATEPEAKS.out.tsv.collect().ifEmpty([]), + SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), + // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) + + params.modules['multiqc'] + ) } //////////////////////////////////////////////////// From 630905ed43690f55003cf8ddc41d817a050ffb32 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 3 Aug 2020 20:00:34 +0100 Subject: [PATCH 127/538] Add publishDir --- conf/modules.config | 1 + 1 file changed, 1 insertion(+) diff --git a/conf/modules.config b/conf/modules.config index 3d7125b92..e2a7f7287 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -171,6 +171,7 @@ params { publish_dir = "igv" } 'get_software_versions' { + publish_dir = "pipeline_info" publish_files = ['csv':''] } 'output_documentation' { From 8cbfafb3ed23c8e230fa716b5fa1338c166cb456 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 4 Aug 2020 13:23:38 +0100 Subject: [PATCH 128/538] Update saveFiles logic --- modules/nf-core/software/bwa_index.nf | 10 ++--- modules/nf-core/software/bwa_mem.nf | 10 ++--- .../software/deeptools_computematrix.nf | 10 ++--- .../software/deeptools_plotfingerprint.nf | 12 +++--- .../nf-core/software/deeptools_plotheatmap.nf | 8 ++-- .../nf-core/software/deeptools_plotprofile.nf | 8 ++-- modules/nf-core/software/fastqc.nf | 12 +++--- modules/nf-core/software/functions.nf | 42 +++++++++++++------ .../nf-core/software/homer_annotatepeaks.nf | 8 ++-- modules/nf-core/software/macs2_callpeak.nf | 8 ++-- .../nf-core/software/phantompeakqualtools.nf | 6 +-- .../software/picard_collectmultiplemetrics.nf | 8 ++-- .../nf-core/software/picard_markduplicates.nf | 8 ++-- .../nf-core/software/picard_mergesamfiles.nf | 8 ++-- modules/nf-core/software/preseq_lcextrap.nf | 8 ++-- modules/nf-core/software/samtools_flagstat.nf | 8 ++-- modules/nf-core/software/samtools_idxstats.nf | 8 ++-- modules/nf-core/software/samtools_index.nf | 8 ++-- modules/nf-core/software/samtools_sort.nf | 6 +-- modules/nf-core/software/samtools_stats.nf | 8 ++-- .../nf-core/software/subread_featurecounts.nf | 6 +-- modules/nf-core/software/trimgalore.nf | 8 ++-- .../nf-core/software/ucsc_bedgraphtobigwig.nf | 8 ++-- 23 files changed, 123 insertions(+), 103 deletions(-) diff --git a/modules/nf-core/software/bwa_index.nf b/modules/nf-core/software/bwa_index.nf index c5a92e529..a698d211f 100644 --- a/modules/nf-core/software/bwa_index.nf +++ b/modules/nf-core/software/bwa_index.nf @@ -1,12 +1,12 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process BWA_INDEX { tag "$fasta" label 'process_high' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id='') } container "biocontainers/bwa:v0.7.17_cv1" //container "https://depot.galaxyproject.org/singularity/bwa:0.7.17--hed695b0_7" @@ -22,8 +22,8 @@ process BWA_INDEX { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) """ bwa index $ioptions.args $fasta echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${software}.version.txt diff --git a/modules/nf-core/software/bwa_mem.nf b/modules/nf-core/software/bwa_mem.nf index 0a749e402..0fe737959 100644 --- a/modules/nf-core/software/bwa_mem.nf +++ b/modules/nf-core/software/bwa_mem.nf @@ -1,12 +1,12 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process BWA_MEM { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } container "quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" //container "https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" @@ -24,8 +24,8 @@ process BWA_MEM { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" rg = meta.read_group ? "-R ${meta.read_group}" : "" """ diff --git a/modules/nf-core/software/deeptools_computematrix.nf b/modules/nf-core/software/deeptools_computematrix.nf index 86be86dec..7151b1b51 100644 --- a/modules/nf-core/software/deeptools_computematrix.nf +++ b/modules/nf-core/software/deeptools_computematrix.nf @@ -1,12 +1,12 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process DEEPTOOLS_COMPUTEMATRIX { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" @@ -24,8 +24,8 @@ process DEEPTOOLS_COMPUTEMATRIX { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ computeMatrix \\ diff --git a/modules/nf-core/software/deeptools_plotfingerprint.nf b/modules/nf-core/software/deeptools_plotfingerprint.nf index 9326dd586..dd2896817 100644 --- a/modules/nf-core/software/deeptools_plotfingerprint.nf +++ b/modules/nf-core/software/deeptools_plotfingerprint.nf @@ -1,13 +1,13 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process DEEPTOOLS_PLOTFINGERPRINT { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" @@ -24,8 +24,8 @@ process DEEPTOOLS_PLOTFINGERPRINT { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" extend = (meta.single_end && params.fragment_size > 0) ? "--extendReads ${params.fragment_size}" : '' """ diff --git a/modules/nf-core/software/deeptools_plotheatmap.nf b/modules/nf-core/software/deeptools_plotheatmap.nf index 68dcfcc90..8bd5b2a4c 100644 --- a/modules/nf-core/software/deeptools_plotheatmap.nf +++ b/modules/nf-core/software/deeptools_plotheatmap.nf @@ -1,13 +1,13 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process DEEPTOOLS_PLOTHEATMAP { tag "$meta.id" label 'process_low' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" diff --git a/modules/nf-core/software/deeptools_plotprofile.nf b/modules/nf-core/software/deeptools_plotprofile.nf index 457b55a38..7db9ba698 100644 --- a/modules/nf-core/software/deeptools_plotprofile.nf +++ b/modules/nf-core/software/deeptools_plotprofile.nf @@ -1,13 +1,13 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process DEEPTOOLS_PLOTPROFILE { tag "$meta.id" label 'process_low' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" diff --git a/modules/nf-core/software/fastqc.nf b/modules/nf-core/software/fastqc.nf index e3c8f0d04..c8e483fb7 100644 --- a/modules/nf-core/software/fastqc.nf +++ b/modules/nf-core/software/fastqc.nf @@ -1,13 +1,13 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process FASTQC { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/fastqc:0.11.9--0" //container "https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0" @@ -22,9 +22,11 @@ process FASTQC { tuple val(meta), path("*.zip"), emit: zip path "*.version.txt", emit: version + echo true + script: // Add soft-links to original FastQs for consistent naming in pipeline - def software = task.process.toLowerCase() + def software = getSoftwareName(task.process) def ioptions = initOptions(options, software) prefix = ioptions.suffix ? "${meta.id}.${ioptions.suffix}" : "${meta.id}" if (meta.single_end) { diff --git a/modules/nf-core/software/functions.nf b/modules/nf-core/software/functions.nf index 40f226d00..691904fbd 100644 --- a/modules/nf-core/software/functions.nf +++ b/modules/nf-core/software/functions.nf @@ -1,38 +1,56 @@ +/* + * Extract name of software from nf-core/modules process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + /* * Function to initialise default values and to generate a Groovy Map of module options */ -def initOptions(Map args, String publish_dir) { +def initOptions(Map args) { def Map options = [:] options.args = args.args ?: '' options.args2 = args.args2 ?: '' options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ? args.publish_dir : publish_dir + options.publish_dir = args.publish_dir ?: '' options.publish_files = args.publish_files ?: null options.suffix = args.suffix ?: '' return options } +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + /* * Function to save/publish module results * if publish_files == null : All files are published * if publish_files == Map [:] : No files are published * if publish_files == Map [ext:path] : Only files that end with "ext" are published to "path" (appended to output directory) */ -def saveFiles(filename, options, publish_dir) { +def saveFiles(filename, options, publish_dir='', publish_id='') { if (!filename.endsWith('.version.txt')) { - def publish_files = initOptions(options, publish_dir).publish_files - if (publish_files instanceof Map) { - for (ext in publish_files) { + def ioptions = initOptions(options) + def path_list = [ ioptions.publish_dir ?: publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { if (filename.endsWith(ext.key)) { - if (ext.value) { - return "${ext.value}/$filename" - } else { - return filename - } + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "/${getPathFromList(ext_list)}/$filename" } } } else { - return filename + return "/${getPathFromList(path_list)}/$filename" } } } diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf index 0697dac94..927affd61 100644 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ b/modules/nf-core/software/homer_annotatepeaks.nf @@ -1,15 +1,15 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' def VERSION = '4.11' process HOMER_ANNOTATEPEAKS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/homer:4.11--pl526h9a982cc_2" //container "https://depot.galaxyproject.org/singularity/homer:4.11--pl526h9a982cc_2" diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf index dcd89ea63..963f2bb06 100644 --- a/modules/nf-core/software/macs2_callpeak.nf +++ b/modules/nf-core/software/macs2_callpeak.nf @@ -1,13 +1,13 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process MACS2_CALLPEAK { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/macs2:2.2.7.1--py37h516909a_0" //container "https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py37h516909a_0" diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf index d3e9bee54..c18892df7 100644 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ b/modules/nf-core/software/phantompeakqualtools.nf @@ -1,14 +1,14 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' def VERSION = '1.2.2' process PHANTOMPEAKQUALTOOLS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } container "quay.io/biocontainers/phantompeakqualtools:1.2.2--0" //container "https://depot.galaxyproject.org/singularity/phantompeakqualtools:1.2.2--0" diff --git a/modules/nf-core/software/picard_collectmultiplemetrics.nf b/modules/nf-core/software/picard_collectmultiplemetrics.nf index 084dde433..6cbf65cf3 100644 --- a/modules/nf-core/software/picard_collectmultiplemetrics.nf +++ b/modules/nf-core/software/picard_collectmultiplemetrics.nf @@ -1,13 +1,13 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process PICARD_COLLECTMULTIPLEMETRICS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" diff --git a/modules/nf-core/software/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf index deee9411f..c8645ec65 100644 --- a/modules/nf-core/software/picard_markduplicates.nf +++ b/modules/nf-core/software/picard_markduplicates.nf @@ -1,13 +1,13 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process PICARD_MARKDUPLICATES { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" diff --git a/modules/nf-core/software/picard_mergesamfiles.nf b/modules/nf-core/software/picard_mergesamfiles.nf index 78522731c..283ac1a72 100644 --- a/modules/nf-core/software/picard_mergesamfiles.nf +++ b/modules/nf-core/software/picard_mergesamfiles.nf @@ -1,13 +1,13 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process PICARD_MERGESAMFILES { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" diff --git a/modules/nf-core/software/preseq_lcextrap.nf b/modules/nf-core/software/preseq_lcextrap.nf index 2fb445f7e..39e859403 100644 --- a/modules/nf-core/software/preseq_lcextrap.nf +++ b/modules/nf-core/software/preseq_lcextrap.nf @@ -1,14 +1,14 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process PRESEQ_LCEXTRAP { tag "$meta.id" label 'process_medium' label 'error_ignore' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/preseq:2.0.3--hf53bd2b_3" //container "https://depot.galaxyproject.org/singularity/preseq:2.0.3--hf53bd2b_3" diff --git a/modules/nf-core/software/samtools_flagstat.nf b/modules/nf-core/software/samtools_flagstat.nf index 349612b33..2f1c830cb 100644 --- a/modules/nf-core/software/samtools_flagstat.nf +++ b/modules/nf-core/software/samtools_flagstat.nf @@ -1,12 +1,12 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process SAMTOOLS_FLAGSTAT { tag "$meta.id" - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_idxstats.nf b/modules/nf-core/software/samtools_idxstats.nf index 9eb578efd..7c4ac39ad 100644 --- a/modules/nf-core/software/samtools_idxstats.nf +++ b/modules/nf-core/software/samtools_idxstats.nf @@ -1,12 +1,12 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process SAMTOOLS_IDXSTATS { tag "$meta.id" - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_index.nf b/modules/nf-core/software/samtools_index.nf index 95f28ebe2..1ff7a7d85 100644 --- a/modules/nf-core/software/samtools_index.nf +++ b/modules/nf-core/software/samtools_index.nf @@ -1,12 +1,12 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process SAMTOOLS_INDEX { tag "$meta.id" - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_sort.nf b/modules/nf-core/software/samtools_sort.nf index 7aff6a57d..40f54a768 100644 --- a/modules/nf-core/software/samtools_sort.nf +++ b/modules/nf-core/software/samtools_sort.nf @@ -1,12 +1,12 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process SAMTOOLS_SORT { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_stats.nf b/modules/nf-core/software/samtools_stats.nf index e30228e75..34feac667 100644 --- a/modules/nf-core/software/samtools_stats.nf +++ b/modules/nf-core/software/samtools_stats.nf @@ -1,12 +1,12 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process SAMTOOLS_STATS { tag "$meta.id" - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/subread_featurecounts.nf b/modules/nf-core/software/subread_featurecounts.nf index 5104b5d94..eb7606090 100644 --- a/modules/nf-core/software/subread_featurecounts.nf +++ b/modules/nf-core/software/subread_featurecounts.nf @@ -1,12 +1,12 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process SUBREAD_FEATURECOUNTS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" //container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" diff --git a/modules/nf-core/software/trimgalore.nf b/modules/nf-core/software/trimgalore.nf index e430ef738..726794aca 100644 --- a/modules/nf-core/software/trimgalore.nf +++ b/modules/nf-core/software/trimgalore.nf @@ -1,13 +1,13 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process TRIMGALORE { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/trim-galore:0.6.5--0" //container "https://depot.galaxyproject.org/singularity/trim-galore:0.6.5--0" diff --git a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf index 6f5126e5e..a642205bd 100644 --- a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf +++ b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf @@ -1,15 +1,15 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' def VERSION = '377' process UCSC_BEDRAPHTOBIGWIG { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + container "quay.io/biocontainers/ucsc-bedgraphtobigwig:377--h446ed27_1" //container "https://depot.galaxyproject.org/singularity/ucsc-bedgraphtobigwig:377--h446ed27_1" From 7bfae43f887b85e5192674b0891f4356f9793708 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 4 Aug 2020 13:32:15 +0100 Subject: [PATCH 129/538] Use updated logic to publish file --- modules/nf-core/software/deeptools_plotheatmap.nf | 6 +++--- modules/nf-core/software/deeptools_plotprofile.nf | 6 +++--- modules/nf-core/software/fastqc.nf | 6 ++---- modules/nf-core/software/homer_annotatepeaks.nf | 6 +++--- modules/nf-core/software/macs2_callpeak.nf | 6 +++--- modules/nf-core/software/phantompeakqualtools.nf | 4 ++-- modules/nf-core/software/picard_collectmultiplemetrics.nf | 6 +++--- modules/nf-core/software/picard_markduplicates.nf | 6 +++--- modules/nf-core/software/picard_mergesamfiles.nf | 6 +++--- modules/nf-core/software/preseq_lcextrap.nf | 6 +++--- modules/nf-core/software/samtools_flagstat.nf | 4 ++-- modules/nf-core/software/samtools_idxstats.nf | 4 ++-- modules/nf-core/software/samtools_index.nf | 4 ++-- modules/nf-core/software/samtools_sort.nf | 6 +++--- modules/nf-core/software/samtools_stats.nf | 4 ++-- modules/nf-core/software/subread_featurecounts.nf | 6 +++--- modules/nf-core/software/trimgalore.nf | 6 +++--- modules/nf-core/software/ucsc_bedgraphtobigwig.nf | 6 +++--- 18 files changed, 48 insertions(+), 50 deletions(-) diff --git a/modules/nf-core/software/deeptools_plotheatmap.nf b/modules/nf-core/software/deeptools_plotheatmap.nf index 8bd5b2a4c..10ce9ae66 100644 --- a/modules/nf-core/software/deeptools_plotheatmap.nf +++ b/modules/nf-core/software/deeptools_plotheatmap.nf @@ -7,7 +7,7 @@ process DEEPTOOLS_PLOTHEATMAP { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" @@ -23,8 +23,8 @@ process DEEPTOOLS_PLOTHEATMAP { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ plotHeatmap \\ diff --git a/modules/nf-core/software/deeptools_plotprofile.nf b/modules/nf-core/software/deeptools_plotprofile.nf index 7db9ba698..3cea35525 100644 --- a/modules/nf-core/software/deeptools_plotprofile.nf +++ b/modules/nf-core/software/deeptools_plotprofile.nf @@ -7,7 +7,7 @@ process DEEPTOOLS_PLOTPROFILE { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" @@ -23,8 +23,8 @@ process DEEPTOOLS_PLOTPROFILE { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ plotProfile \\ diff --git a/modules/nf-core/software/fastqc.nf b/modules/nf-core/software/fastqc.nf index c8e483fb7..f3864eea1 100644 --- a/modules/nf-core/software/fastqc.nf +++ b/modules/nf-core/software/fastqc.nf @@ -7,7 +7,7 @@ process FASTQC { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/fastqc:0.11.9--0" //container "https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0" @@ -22,12 +22,10 @@ process FASTQC { tuple val(meta), path("*.zip"), emit: zip path "*.version.txt", emit: version - echo true - script: // Add soft-links to original FastQs for consistent naming in pipeline def software = getSoftwareName(task.process) - def ioptions = initOptions(options, software) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}.${ioptions.suffix}" : "${meta.id}" if (meta.single_end) { """ diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf index 927affd61..9958fe75f 100644 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ b/modules/nf-core/software/homer_annotatepeaks.nf @@ -9,7 +9,7 @@ process HOMER_ANNOTATEPEAKS { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/homer:4.11--pl526h9a982cc_2" //container "https://depot.galaxyproject.org/singularity/homer:4.11--pl526h9a982cc_2" @@ -26,8 +26,8 @@ process HOMER_ANNOTATEPEAKS { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ annotatePeaks.pl \\ diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf index 963f2bb06..b38efc5c6 100644 --- a/modules/nf-core/software/macs2_callpeak.nf +++ b/modules/nf-core/software/macs2_callpeak.nf @@ -7,7 +7,7 @@ process MACS2_CALLPEAK { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/macs2:2.2.7.1--py37h516909a_0" //container "https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py37h516909a_0" @@ -27,8 +27,8 @@ process MACS2_CALLPEAK { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" format = meta.single_end ? 'BAM' : 'BAMPE' control = controlbam ? "--control $controlbam" : '' diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf index c18892df7..2c164e3a2 100644 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ b/modules/nf-core/software/phantompeakqualtools.nf @@ -26,8 +26,8 @@ process PHANTOMPEAKQUALTOOLS { path "*.version.txt", emit: version script: - def software = task.process.toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ RUN_SPP=`which run_spp.R` diff --git a/modules/nf-core/software/picard_collectmultiplemetrics.nf b/modules/nf-core/software/picard_collectmultiplemetrics.nf index 6cbf65cf3..acb2a6275 100644 --- a/modules/nf-core/software/picard_collectmultiplemetrics.nf +++ b/modules/nf-core/software/picard_collectmultiplemetrics.nf @@ -7,7 +7,7 @@ process PICARD_COLLECTMULTIPLEMETRICS { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" @@ -24,8 +24,8 @@ process PICARD_COLLECTMULTIPLEMETRICS { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" def avail_mem = 3 if (!task.memory) { diff --git a/modules/nf-core/software/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf index c8645ec65..cfbfed58f 100644 --- a/modules/nf-core/software/picard_markduplicates.nf +++ b/modules/nf-core/software/picard_markduplicates.nf @@ -7,7 +7,7 @@ process PICARD_MARKDUPLICATES { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" @@ -23,8 +23,8 @@ process PICARD_MARKDUPLICATES { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" def avail_mem = 3 if (!task.memory) { diff --git a/modules/nf-core/software/picard_mergesamfiles.nf b/modules/nf-core/software/picard_mergesamfiles.nf index 283ac1a72..f957ddaa2 100644 --- a/modules/nf-core/software/picard_mergesamfiles.nf +++ b/modules/nf-core/software/picard_mergesamfiles.nf @@ -7,7 +7,7 @@ process PICARD_MERGESAMFILES { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" @@ -22,8 +22,8 @@ process PICARD_MERGESAMFILES { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" bam_files = bams.sort() def avail_mem = 3 diff --git a/modules/nf-core/software/preseq_lcextrap.nf b/modules/nf-core/software/preseq_lcextrap.nf index 39e859403..ec80e684a 100644 --- a/modules/nf-core/software/preseq_lcextrap.nf +++ b/modules/nf-core/software/preseq_lcextrap.nf @@ -8,7 +8,7 @@ process PRESEQ_LCEXTRAP { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/preseq:2.0.3--hf53bd2b_3" //container "https://depot.galaxyproject.org/singularity/preseq:2.0.3--hf53bd2b_3" @@ -24,8 +24,8 @@ process PRESEQ_LCEXTRAP { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" pe = meta.single_end ? '' : '-pe' """ diff --git a/modules/nf-core/software/samtools_flagstat.nf b/modules/nf-core/software/samtools_flagstat.nf index 2f1c830cb..d04c205b9 100644 --- a/modules/nf-core/software/samtools_flagstat.nf +++ b/modules/nf-core/software/samtools_flagstat.nf @@ -6,7 +6,7 @@ process SAMTOOLS_FLAGSTAT { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" @@ -21,7 +21,7 @@ process SAMTOOLS_FLAGSTAT { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() + def software = getSoftwareName(task.process) """ samtools flagstat $bam > ${bam}.flagstat echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt diff --git a/modules/nf-core/software/samtools_idxstats.nf b/modules/nf-core/software/samtools_idxstats.nf index 7c4ac39ad..419971e11 100644 --- a/modules/nf-core/software/samtools_idxstats.nf +++ b/modules/nf-core/software/samtools_idxstats.nf @@ -6,7 +6,7 @@ process SAMTOOLS_IDXSTATS { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" @@ -21,7 +21,7 @@ process SAMTOOLS_IDXSTATS { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() + def software = getSoftwareName(task.process) """ samtools idxstats $bam > ${bam}.idxstats echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt diff --git a/modules/nf-core/software/samtools_index.nf b/modules/nf-core/software/samtools_index.nf index 1ff7a7d85..f8f749fd0 100644 --- a/modules/nf-core/software/samtools_index.nf +++ b/modules/nf-core/software/samtools_index.nf @@ -6,7 +6,7 @@ process SAMTOOLS_INDEX { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" @@ -21,7 +21,7 @@ process SAMTOOLS_INDEX { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() + def software = getSoftwareName(task.process) """ samtools index $bam echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt diff --git a/modules/nf-core/software/samtools_sort.nf b/modules/nf-core/software/samtools_sort.nf index 40f54a768..fca94ef3d 100644 --- a/modules/nf-core/software/samtools_sort.nf +++ b/modules/nf-core/software/samtools_sort.nf @@ -7,7 +7,7 @@ process SAMTOOLS_SORT { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" @@ -22,8 +22,8 @@ process SAMTOOLS_SORT { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ samtools sort $ioptions.args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam diff --git a/modules/nf-core/software/samtools_stats.nf b/modules/nf-core/software/samtools_stats.nf index 34feac667..8fbf22e98 100644 --- a/modules/nf-core/software/samtools_stats.nf +++ b/modules/nf-core/software/samtools_stats.nf @@ -6,7 +6,7 @@ process SAMTOOLS_STATS { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" @@ -21,7 +21,7 @@ process SAMTOOLS_STATS { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() + def software = getSoftwareName(task.process) """ samtools stats $bam > ${bam}.stats echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt diff --git a/modules/nf-core/software/subread_featurecounts.nf b/modules/nf-core/software/subread_featurecounts.nf index eb7606090..8e7cc0177 100644 --- a/modules/nf-core/software/subread_featurecounts.nf +++ b/modules/nf-core/software/subread_featurecounts.nf @@ -7,7 +7,7 @@ process SUBREAD_FEATURECOUNTS { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" //container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" @@ -23,8 +23,8 @@ process SUBREAD_FEATURECOUNTS { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" pe = meta.single_end ? '' : '-p' """ diff --git a/modules/nf-core/software/trimgalore.nf b/modules/nf-core/software/trimgalore.nf index 726794aca..a2bcdf6e0 100644 --- a/modules/nf-core/software/trimgalore.nf +++ b/modules/nf-core/software/trimgalore.nf @@ -7,7 +7,7 @@ process TRIMGALORE { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/trim-galore:0.6.5--0" //container "https://depot.galaxyproject.org/singularity/trim-galore:0.6.5--0" @@ -43,8 +43,8 @@ process TRIMGALORE { tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' // Added soft-links to original fastqs for consistent naming in MultiQC - def software = task.process.toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" if (meta.single_end) { """ diff --git a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf index a642205bd..ed9ba99e0 100644 --- a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf +++ b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf @@ -9,7 +9,7 @@ process UCSC_BEDRAPHTOBIGWIG { publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } - + container "quay.io/biocontainers/ucsc-bedgraphtobigwig:377--h446ed27_1" //container "https://depot.galaxyproject.org/singularity/ucsc-bedgraphtobigwig:377--h446ed27_1" @@ -25,8 +25,8 @@ process UCSC_BEDRAPHTOBIGWIG { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ bedGraphToBigWig $bedgraph $sizes ${prefix}.bigWig From a8da381e7449ef996ee14a7d2ae0884fb38b085b Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 4 Aug 2020 14:29:57 +0100 Subject: [PATCH 130/538] Use updated functions.nf --- modules/local/process/bam_filter.nf | 6 +-- modules/local/process/bam_remove_orphans.nf | 6 +-- modules/local/process/bedtools_genomecov.nf | 10 ++--- modules/local/process/frip_score.nf | 6 +-- modules/local/process/functions.nf | 42 +++++++++++++------ modules/local/process/get_chrom_sizes.nf | 6 +-- .../local/process/get_software_versions.nf | 6 +-- modules/local/process/gtf2bed.nf | 6 +-- modules/local/process/igv.nf | 6 +-- modules/local/process/macs2_consensus.nf | 10 ++--- modules/local/process/make_genome_filter.nf | 6 +-- modules/local/process/multiqc.nf | 10 ++--- modules/local/process/multiqc_custom_peaks.nf | 10 ++--- .../multiqc_custom_phantompeakqualtools.nf | 10 ++--- modules/local/process/output_documentation.nf | 6 +-- .../local/process/plot_homer_annotatepeaks.nf | 9 ++-- modules/local/process/plot_macs2_qc.nf | 7 ++-- modules/local/process/samplesheet_check.nf | 6 +-- 18 files changed, 92 insertions(+), 76 deletions(-) diff --git a/modules/local/process/bam_filter.nf b/modules/local/process/bam_filter.nf index 0d6ec5876..fd4b6d570 100644 --- a/modules/local/process/bam_filter.nf +++ b/modules/local/process/bam_filter.nf @@ -7,9 +7,9 @@ include { initOptions; saveFiles } from './functions' process BAM_FILTER { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=task.process.toLowerCase(), publish_id=meta.id) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -25,7 +25,7 @@ process BAM_FILTER { path "*.version.txt", emit: version script: - def ioptions = initOptions(options, task.process.toLowerCase()) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" filter_params = meta.single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' dup_params = params.keep_dups ? '' : '-F 0x0400' diff --git a/modules/local/process/bam_remove_orphans.nf b/modules/local/process/bam_remove_orphans.nf index f17f0d1fa..de9efc737 100644 --- a/modules/local/process/bam_remove_orphans.nf +++ b/modules/local/process/bam_remove_orphans.nf @@ -7,9 +7,9 @@ include { initOptions; saveFiles } from './functions' process BAM_REMOVE_ORPHANS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=task.process.toLowerCase(), publish_id=meta.id) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -21,7 +21,7 @@ process BAM_REMOVE_ORPHANS { tuple val(meta), path("${prefix}.bam"), emit: bam script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - def ioptions = initOptions(options, task.process.toLowerCase()) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" if (!meta.single_end) { """ diff --git a/modules/local/process/bedtools_genomecov.nf b/modules/local/process/bedtools_genomecov.nf index 115902c9f..9eac32aab 100644 --- a/modules/local/process/bedtools_genomecov.nf +++ b/modules/local/process/bedtools_genomecov.nf @@ -1,12 +1,12 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process BEDTOOLS_GENOMECOV { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" @@ -23,8 +23,8 @@ process BEDTOOLS_GENOMECOV { path "*.version.txt", emit: version script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" pe = meta.single_end ? '' : '-pc' extend = (meta.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' diff --git a/modules/local/process/frip_score.nf b/modules/local/process/frip_score.nf index d5e382d78..9399851d4 100644 --- a/modules/local/process/frip_score.nf +++ b/modules/local/process/frip_score.nf @@ -4,9 +4,9 @@ include { initOptions; saveFiles } from './functions' process FRIP_SCORE { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=task.process.toLowerCase(), publish_id=meta.id) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -18,7 +18,7 @@ process FRIP_SCORE { tuple val(meta), path("*.txt"), emit: txt script: - def ioptions = initOptions(options, task.process.tokenize('_')[0].toLowerCase()) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ READS_IN_PEAKS=\$(intersectBed -a $bam -b $peak $ioptions.args | awk -F '\t' '{sum += \$NF} END {print sum}') diff --git a/modules/local/process/functions.nf b/modules/local/process/functions.nf index 40f226d00..691904fbd 100644 --- a/modules/local/process/functions.nf +++ b/modules/local/process/functions.nf @@ -1,38 +1,56 @@ +/* + * Extract name of software from nf-core/modules process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + /* * Function to initialise default values and to generate a Groovy Map of module options */ -def initOptions(Map args, String publish_dir) { +def initOptions(Map args) { def Map options = [:] options.args = args.args ?: '' options.args2 = args.args2 ?: '' options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ? args.publish_dir : publish_dir + options.publish_dir = args.publish_dir ?: '' options.publish_files = args.publish_files ?: null options.suffix = args.suffix ?: '' return options } +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + /* * Function to save/publish module results * if publish_files == null : All files are published * if publish_files == Map [:] : No files are published * if publish_files == Map [ext:path] : Only files that end with "ext" are published to "path" (appended to output directory) */ -def saveFiles(filename, options, publish_dir) { +def saveFiles(filename, options, publish_dir='', publish_id='') { if (!filename.endsWith('.version.txt')) { - def publish_files = initOptions(options, publish_dir).publish_files - if (publish_files instanceof Map) { - for (ext in publish_files) { + def ioptions = initOptions(options) + def path_list = [ ioptions.publish_dir ?: publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { if (filename.endsWith(ext.key)) { - if (ext.value) { - return "${ext.value}/$filename" - } else { - return filename - } + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "/${getPathFromList(ext_list)}/$filename" } } } else { - return filename + return "/${getPathFromList(path_list)}/$filename" } } } diff --git a/modules/local/process/get_chrom_sizes.nf b/modules/local/process/get_chrom_sizes.nf index a76e2cfdd..99e22122b 100644 --- a/modules/local/process/get_chrom_sizes.nf +++ b/modules/local/process/get_chrom_sizes.nf @@ -1,14 +1,14 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { saveFiles } from './functions' /* * Get chromosome sizes from a fasta file */ process GET_CHROM_SIZES { tag "$fasta" - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, "genome") } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir="genome", publish_id='') } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/local/process/get_software_versions.nf b/modules/local/process/get_software_versions.nf index a097e9408..1163b2681 100644 --- a/modules/local/process/get_software_versions.nf +++ b/modules/local/process/get_software_versions.nf @@ -1,13 +1,13 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { saveFiles } from './functions' /* * Parse software version numbers */ process GET_SOFTWARE_VERSIONS { - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, "pipeline_info") } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir="pipeline_info", publish_id='') } input: path versions diff --git a/modules/local/process/gtf2bed.nf b/modules/local/process/gtf2bed.nf index 0f2533773..063b220fe 100644 --- a/modules/local/process/gtf2bed.nf +++ b/modules/local/process/gtf2bed.nf @@ -1,5 +1,5 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { saveFiles } from './functions' /* * Convert GTF file to BED format @@ -7,9 +7,9 @@ include { initOptions; saveFiles } from './functions' process GTF2BED { tag "$gtf" label 'process_low' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, "genome") } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir="genome", publish_id='') } container "quay.io/biocontainers/perl:5.26.2" //container "https://depot.galaxyproject.org/singularity/perl:5.26.2" diff --git a/modules/local/process/igv.nf b/modules/local/process/igv.nf index 0e95f7062..7e7faca2c 100644 --- a/modules/local/process/igv.nf +++ b/modules/local/process/igv.nf @@ -1,13 +1,13 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { saveFiles } from './functions' /* * Create IGV session file */ process IGV { - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=task.process.toLowerCase(), publish_id='') } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/macs2_consensus.nf b/modules/local/process/macs2_consensus.nf index be6d85d23..18cef6e54 100644 --- a/modules/local/process/macs2_consensus.nf +++ b/modules/local/process/macs2_consensus.nf @@ -1,5 +1,5 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' /* * Consensus peaks across samples, create boolean filtering file, SAF file for featureCounts @@ -7,9 +7,9 @@ include { initOptions; saveFiles } from './functions' process MACS2_CONSENSUS { tag "$meta.id" label 'process_long' - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -26,8 +26,8 @@ process MACS2_CONSENSUS { script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ if (meta.multiple_groups || meta.replicates_exist) { - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}.consensus_peaks" : "${meta.id}.consensus_peaks" peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') diff --git a/modules/local/process/make_genome_filter.nf b/modules/local/process/make_genome_filter.nf index 215e88d8a..1910d6f2d 100644 --- a/modules/local/process/make_genome_filter.nf +++ b/modules/local/process/make_genome_filter.nf @@ -1,14 +1,14 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { saveFiles } from './functions' /* * Prepare genome intervals for filtering by removing regions in blacklist file */ process MAKE_GENOME_FILTER { tag "$sizes" - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, "genome") } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir="genome", publish_id='') } container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" diff --git a/modules/local/process/multiqc.nf b/modules/local/process/multiqc.nf index 395dd0c5e..f90de009f 100644 --- a/modules/local/process/multiqc.nf +++ b/modules/local/process/multiqc.nf @@ -1,5 +1,5 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' // Has the run name been specified by the user? // this has the bonus effect of catching both -name and --name @@ -10,9 +10,9 @@ if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { process MULTIQC { label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id='') } container "quay.io/biocontainers/multiqc:1.9--pyh9f0ad1d_0" //container "https://depot.galaxyproject.org/singularity/multiqc:1.9--pyh9f0ad1d_0" @@ -65,8 +65,8 @@ process MULTIQC { path "*_data", emit: data script: - def software = task.process.toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) rtitle = custom_runName ? "--title \"$custom_runName\"" : '' rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' custom_config_file = params.multiqc_config ? "--config $mqc_custom_config" : '' diff --git a/modules/local/process/multiqc_custom_peaks.nf b/modules/local/process/multiqc_custom_peaks.nf index 7c5d4bad2..8e10a1bd6 100644 --- a/modules/local/process/multiqc_custom_peaks.nf +++ b/modules/local/process/multiqc_custom_peaks.nf @@ -1,11 +1,11 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process MULTIQC_CUSTOM_PEAKS { tag "$meta.id" - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir} ", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -20,8 +20,8 @@ process MULTIQC_CUSTOM_PEAKS { tuple val(meta), path("*.FRiP_mqc.tsv"), emit: frip script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ cat $peak | wc -l | awk -v OFS='\t' '{ print "${prefix}", \$1 }' | cat $peak_count_header - > ${prefix}.peak_count_mqc.tsv diff --git a/modules/local/process/multiqc_custom_phantompeakqualtools.nf b/modules/local/process/multiqc_custom_phantompeakqualtools.nf index 3dc7ef9be..cbd38c255 100644 --- a/modules/local/process/multiqc_custom_phantompeakqualtools.nf +++ b/modules/local/process/multiqc_custom_phantompeakqualtools.nf @@ -1,11 +1,11 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { initOptions; saveFiles; getSoftwareName } from './functions' process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { tag "$meta.id" - publishDir "${params.outdir}/${options.publish_dir}${options.publish_by_id ? "/${meta.id}" : ''}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[0].toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -22,8 +22,8 @@ process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { tuple val(meta), path("*.spp_correlation_mqc.tsv"), emit: correlation script: - def software = task.process.tokenize('_')[0].toLowerCase() - def ioptions = initOptions(options, software) + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ cp $correlation_header ${prefix}.spp_correlation_mqc.tsv diff --git a/modules/local/process/output_documentation.nf b/modules/local/process/output_documentation.nf index 80e18d14f..a07c9e973 100644 --- a/modules/local/process/output_documentation.nf +++ b/modules/local/process/output_documentation.nf @@ -1,13 +1,13 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { saveFiles } from './functions' /* * Output Markdown documentation to HTML */ process OUTPUT_DOCUMENTATION { - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, "pipeline_info") } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir="pipeline_info", publish_id='') } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/plot_homer_annotatepeaks.nf b/modules/local/process/plot_homer_annotatepeaks.nf index 4d5665756..649a0cfd3 100644 --- a/modules/local/process/plot_homer_annotatepeaks.nf +++ b/modules/local/process/plot_homer_annotatepeaks.nf @@ -6,10 +6,10 @@ include { initOptions; saveFiles } from './functions' */ process PLOT_HOMER_ANNOTATEPEAKS { label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[1].toLowerCase()) } - + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=task.process.toLowerCase(), publish_id='') } + conda (params.conda ? "${baseDir}/environment.yml" : null) input: @@ -24,8 +24,7 @@ process PLOT_HOMER_ANNOTATEPEAKS { path '*.tsv', emit: tsv script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - def software = task.process.tokenize('_')[1].toLowerCase() - def ioptions = initOptions(options, software) + def ioptions = initOptions(options) """ plot_homer_annotatepeaks.r \\ -i ${annos.join(',')} \\ diff --git a/modules/local/process/plot_macs2_qc.nf b/modules/local/process/plot_macs2_qc.nf index 9ecb4a944..d40a8d954 100644 --- a/modules/local/process/plot_macs2_qc.nf +++ b/modules/local/process/plot_macs2_qc.nf @@ -6,9 +6,9 @@ include { initOptions; saveFiles } from './functions' */ process PLOT_MACS2_QC { label 'process_medium' - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, task.process.tokenize('_')[1].toLowerCase()) } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=task.process.toLowerCase(), publish_id='') } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -21,8 +21,7 @@ process PLOT_MACS2_QC { path '*.pdf', emit: pdf script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - def software = task.process.tokenize('_')[1].toLowerCase() - def ioptions = initOptions(options, software) + def ioptions = initOptions(options) peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' """ plot_macs2_qc.r \\ diff --git a/modules/local/process/samplesheet_check.nf b/modules/local/process/samplesheet_check.nf index 35c4e3bda..5c393ed39 100644 --- a/modules/local/process/samplesheet_check.nf +++ b/modules/local/process/samplesheet_check.nf @@ -1,14 +1,14 @@ // Import generic module functions -include { initOptions; saveFiles } from './functions' +include { saveFiles } from './functions' /* * Reformat design file, check validitiy and create IP vs control mappings */ process SAMPLESHEET_CHECK { tag "$samplesheet" - publishDir "${params.outdir}/${options.publish_dir}", + publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename, options, "pipeline_info") } + saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir="pipeline_info", publish_id='') } conda (params.conda ? "${baseDir}/environment.yml" : null) From f71daa5635a54e31ed98ceeb168c76bc2bd0f05a Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 4 Aug 2020 14:39:06 +0100 Subject: [PATCH 131/538] Remove starting slash --- modules/local/process/functions.nf | 4 ++-- modules/nf-core/software/functions.nf | 4 ++-- 2 files changed, 4 insertions(+), 4 deletions(-) diff --git a/modules/local/process/functions.nf b/modules/local/process/functions.nf index 691904fbd..dfeab8a87 100644 --- a/modules/local/process/functions.nf +++ b/modules/local/process/functions.nf @@ -46,11 +46,11 @@ def saveFiles(filename, options, publish_dir='', publish_id='') { if (filename.endsWith(ext.key)) { def ext_list = path_list.collect() ext_list.add(ext.value) - return "/${getPathFromList(ext_list)}/$filename" + return "${getPathFromList(ext_list)}/$filename" } } } else { - return "/${getPathFromList(path_list)}/$filename" + return "${getPathFromList(path_list)}/$filename" } } } diff --git a/modules/nf-core/software/functions.nf b/modules/nf-core/software/functions.nf index 691904fbd..dfeab8a87 100644 --- a/modules/nf-core/software/functions.nf +++ b/modules/nf-core/software/functions.nf @@ -46,11 +46,11 @@ def saveFiles(filename, options, publish_dir='', publish_id='') { if (filename.endsWith(ext.key)) { def ext_list = path_list.collect() ext_list.add(ext.value) - return "/${getPathFromList(ext_list)}/$filename" + return "${getPathFromList(ext_list)}/$filename" } } } else { - return "/${getPathFromList(path_list)}/$filename" + return "${getPathFromList(path_list)}/$filename" } } } From 79b00f4cd5b15c8a31c7a02b231b8dea49d3ab93 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 4 Aug 2020 14:50:12 +0100 Subject: [PATCH 132/538] Add some docs --- conf/modules.config | 6 ++---- modules/local/process/functions.nf | 2 +- modules/nf-core/software/functions.nf | 2 +- 3 files changed, 4 insertions(+), 6 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index e2a7f7287..e95dfaf50 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -4,17 +4,15 @@ * ------------------------------------------------- * * Available keys to override module options: - * MANDATORY - * publish_dir = Directory to publish results. - * - * OPTIONAL * args = Additional arguments appended to command in module. * args2 = Second set of arguments appended to command in module (multi-tool modules). * publish_by_id = Publish results in separate folders by meta.id value. + * publish_dir = Directory to publish results. * publish_files = Groovy map where key = "file_ext" and value = "directory" to only publish results * for a particular file extension. The value of "directory" is appended to the standard * "publish_dir" path as defined above. * suffix = File name suffix for output files + * */ params { diff --git a/modules/local/process/functions.nf b/modules/local/process/functions.nf index dfeab8a87..2bc9b8a08 100644 --- a/modules/local/process/functions.nf +++ b/modules/local/process/functions.nf @@ -6,7 +6,7 @@ def getSoftwareName(task_process) { } /* - * Function to initialise default values and to generate a Groovy Map of module options + * Function to initialise default values and to generate a Groovy Map of nf-core module options */ def initOptions(Map args) { def Map options = [:] diff --git a/modules/nf-core/software/functions.nf b/modules/nf-core/software/functions.nf index dfeab8a87..2bc9b8a08 100644 --- a/modules/nf-core/software/functions.nf +++ b/modules/nf-core/software/functions.nf @@ -6,7 +6,7 @@ def getSoftwareName(task_process) { } /* - * Function to initialise default values and to generate a Groovy Map of module options + * Function to initialise default values and to generate a Groovy Map of nf-core module options */ def initOptions(Map args) { def Map options = [:] From 3bc6332ba367e573c6df7cd2afa82152af051e63 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 4 Aug 2020 14:52:28 +0100 Subject: [PATCH 133/538] Update help --- conf/modules.config | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index e95dfaf50..4587ddb1e 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -1,7 +1,7 @@ /* - * ------------------------------------------------- - * Nextflow config file for module specific-options - * ------------------------------------------------- + * -------------------------------------------------- + * Config file for defining DSL2 per module options + * -------------------------------------------------- * * Available keys to override module options: * args = Additional arguments appended to command in module. From e282df2b645e318e2c8893ea37f35d94db1e8579 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 4 Aug 2020 15:02:28 +0100 Subject: [PATCH 134/538] Add more docs annotation --- conf/modules.config | 2 ++ modules/local/process/functions.nf | 13 ++++++++----- modules/nf-core/software/functions.nf | 13 ++++++++----- 3 files changed, 18 insertions(+), 10 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 4587ddb1e..8ed9b7729 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -11,6 +11,8 @@ * publish_files = Groovy map where key = "file_ext" and value = "directory" to only publish results * for a particular file extension. The value of "directory" is appended to the standard * "publish_dir" path as defined above. + * If publish_files == null (unspecified) - All files are published. + * If publish_files == Map [:] (empty map) - No files are published. * suffix = File name suffix for output files * */ diff --git a/modules/local/process/functions.nf b/modules/local/process/functions.nf index 2bc9b8a08..a2c0d6ce1 100644 --- a/modules/local/process/functions.nf +++ b/modules/local/process/functions.nf @@ -1,12 +1,18 @@ /* - * Extract name of software from nf-core/modules process name using $task.process + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process */ def getSoftwareName(task_process) { return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() } /* - * Function to initialise default values and to generate a Groovy Map of nf-core module options + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules */ def initOptions(Map args) { def Map options = [:] @@ -30,9 +36,6 @@ def getPathFromList(path_list) { /* * Function to save/publish module results - * if publish_files == null : All files are published - * if publish_files == Map [:] : No files are published - * if publish_files == Map [ext:path] : Only files that end with "ext" are published to "path" (appended to output directory) */ def saveFiles(filename, options, publish_dir='', publish_id='') { if (!filename.endsWith('.version.txt')) { diff --git a/modules/nf-core/software/functions.nf b/modules/nf-core/software/functions.nf index 2bc9b8a08..a2c0d6ce1 100644 --- a/modules/nf-core/software/functions.nf +++ b/modules/nf-core/software/functions.nf @@ -1,12 +1,18 @@ /* - * Extract name of software from nf-core/modules process name using $task.process + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process */ def getSoftwareName(task_process) { return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() } /* - * Function to initialise default values and to generate a Groovy Map of nf-core module options + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules */ def initOptions(Map args) { def Map options = [:] @@ -30,9 +36,6 @@ def getPathFromList(path_list) { /* * Function to save/publish module results - * if publish_files == null : All files are published - * if publish_files == Map [:] : No files are published - * if publish_files == Map [ext:path] : Only files that end with "ext" are published to "path" (appended to output directory) */ def saveFiles(filename, options, publish_dir='', publish_id='') { if (!filename.endsWith('.version.txt')) { From b3d4943013ec8a61929bec6d458d615d358ae33d Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 4 Aug 2020 15:28:15 +0100 Subject: [PATCH 135/538] Remove options if default value alreadty --- conf/modules.config | 20 -------------------- main.nf | 12 ++++++------ 2 files changed, 6 insertions(+), 26 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 8ed9b7729..f7bb77dd5 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -19,30 +19,16 @@ params { modules { - 'samplesheet_check' { - publish_dir = "pipeline_info" - } 'fastqc' { args = "--quiet" - publish_dir = "fastqc" } 'trimgalore' { args = "--fastqc" - publish_dir = "trimgalore" } 'bwa_index' { args = "-a bwtsw" publish_dir = "genome/bwa_index" } - 'gtf2bed' { - publish_dir = "genome" - } - 'make_genome_filter' { - publish_dir = "genome" - } - 'get_chrom_sizes' { - publish_dir = "genome" - } 'bwa_mem' { args = "-M" args2 = "-h -F 0x0100 -O BAM" @@ -167,16 +153,10 @@ params { 'deseq2_featurecounts' { publish_dir = "bwa/mergedLibrary/macs2" } - 'igv' { - publish_dir = "igv" - } 'get_software_versions' { publish_dir = "pipeline_info" publish_files = ['csv':''] } - 'output_documentation' { - publish_dir = "pipeline_info" - } 'multiqc' { publish_dir = "multiqc" } diff --git a/main.nf b/main.nf index caf6e30f6..114dac5ec 100755 --- a/main.nf +++ b/main.nf @@ -186,7 +186,7 @@ workflow { INPUT_CHECK ( ch_input, params.seq_center, - params.modules['samplesheet_check'] + [:] ) /* @@ -194,12 +194,12 @@ workflow { */ ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta, params.modules['bwa_index'] ).index - if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf, params.modules['gtf2bed'] ) } + if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf, [:] ) } MAKE_GENOME_FILTER ( - GET_CHROM_SIZES ( ch_fasta, params.modules['get_chrom_sizes'] ).sizes, + GET_CHROM_SIZES ( ch_fasta, [:] ).sizes, ch_blacklist.ifEmpty([]), - params.modules['make_genome_filter'] + [:] ) ch_software_versions = Channel.empty() ch_software_versions = ch_software_versions.mix(MAKE_GENOME_FILTER.out.version.first().ifEmpty(null)) @@ -518,7 +518,7 @@ workflow { params.modules['ucsc_bedgraphtobigwig'], params.modules['macs2_callpeak'], params.modules['macs2_consensus'], - params.modules['igv'] + [:] ) /* @@ -532,7 +532,7 @@ workflow { OUTPUT_DOCUMENTATION ( ch_output_docs, ch_output_docs_images, - params.modules['output_documentation'] + [:] ) /* From f1eef741026ad119b914b00e723115309568f6de Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 4 Aug 2020 16:52:23 +0100 Subject: [PATCH 136/538] Replace = with : --- modules/nf-core/software/bwa_index.nf | 2 +- modules/nf-core/software/bwa_mem.nf | 2 +- .../software/deeptools_computematrix.nf | 2 +- .../software/deeptools_plotfingerprint.nf | 2 +- .../nf-core/software/deeptools_plotheatmap.nf | 2 +- .../nf-core/software/deeptools_plotprofile.nf | 2 +- modules/nf-core/software/fastqc.nf | 2 +- modules/nf-core/software/functions.nf | 22 +++++++++---------- .../nf-core/software/homer_annotatepeaks.nf | 2 +- modules/nf-core/software/macs2_callpeak.nf | 2 +- .../nf-core/software/phantompeakqualtools.nf | 2 +- .../software/picard_collectmultiplemetrics.nf | 2 +- .../nf-core/software/picard_markduplicates.nf | 2 +- .../nf-core/software/picard_mergesamfiles.nf | 2 +- modules/nf-core/software/preseq_lcextrap.nf | 2 +- modules/nf-core/software/samtools_flagstat.nf | 2 +- modules/nf-core/software/samtools_idxstats.nf | 2 +- modules/nf-core/software/samtools_index.nf | 2 +- modules/nf-core/software/samtools_sort.nf | 2 +- modules/nf-core/software/samtools_stats.nf | 2 +- .../nf-core/software/subread_featurecounts.nf | 2 +- modules/nf-core/software/trimgalore.nf | 2 +- .../nf-core/software/ucsc_bedgraphtobigwig.nf | 2 +- 23 files changed, 33 insertions(+), 33 deletions(-) diff --git a/modules/nf-core/software/bwa_index.nf b/modules/nf-core/software/bwa_index.nf index a698d211f..38b86c1fb 100644 --- a/modules/nf-core/software/bwa_index.nf +++ b/modules/nf-core/software/bwa_index.nf @@ -6,7 +6,7 @@ process BWA_INDEX { label 'process_high' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id='') } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:'') } container "biocontainers/bwa:v0.7.17_cv1" //container "https://depot.galaxyproject.org/singularity/bwa:0.7.17--hed695b0_7" diff --git a/modules/nf-core/software/bwa_mem.nf b/modules/nf-core/software/bwa_mem.nf index 0fe737959..1b231240f 100644 --- a/modules/nf-core/software/bwa_mem.nf +++ b/modules/nf-core/software/bwa_mem.nf @@ -6,7 +6,7 @@ process BWA_MEM { label 'process_high' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" //container "https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" diff --git a/modules/nf-core/software/deeptools_computematrix.nf b/modules/nf-core/software/deeptools_computematrix.nf index 7151b1b51..0c505e419 100644 --- a/modules/nf-core/software/deeptools_computematrix.nf +++ b/modules/nf-core/software/deeptools_computematrix.nf @@ -6,7 +6,7 @@ process DEEPTOOLS_COMPUTEMATRIX { label 'process_high' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" diff --git a/modules/nf-core/software/deeptools_plotfingerprint.nf b/modules/nf-core/software/deeptools_plotfingerprint.nf index dd2896817..9304e836c 100644 --- a/modules/nf-core/software/deeptools_plotfingerprint.nf +++ b/modules/nf-core/software/deeptools_plotfingerprint.nf @@ -6,7 +6,7 @@ process DEEPTOOLS_PLOTFINGERPRINT { label 'process_high' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" diff --git a/modules/nf-core/software/deeptools_plotheatmap.nf b/modules/nf-core/software/deeptools_plotheatmap.nf index 10ce9ae66..3e8f78d77 100644 --- a/modules/nf-core/software/deeptools_plotheatmap.nf +++ b/modules/nf-core/software/deeptools_plotheatmap.nf @@ -6,7 +6,7 @@ process DEEPTOOLS_PLOTHEATMAP { label 'process_low' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" diff --git a/modules/nf-core/software/deeptools_plotprofile.nf b/modules/nf-core/software/deeptools_plotprofile.nf index 3cea35525..a822066b8 100644 --- a/modules/nf-core/software/deeptools_plotprofile.nf +++ b/modules/nf-core/software/deeptools_plotprofile.nf @@ -6,7 +6,7 @@ process DEEPTOOLS_PLOTPROFILE { label 'process_low' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/deeptools:3.4.3--py_0" //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" diff --git a/modules/nf-core/software/fastqc.nf b/modules/nf-core/software/fastqc.nf index f3864eea1..8b66fd360 100644 --- a/modules/nf-core/software/fastqc.nf +++ b/modules/nf-core/software/fastqc.nf @@ -6,7 +6,7 @@ process FASTQC { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/fastqc:0.11.9--0" //container "https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0" diff --git a/modules/nf-core/software/functions.nf b/modules/nf-core/software/functions.nf index a2c0d6ce1..75553cdf5 100644 --- a/modules/nf-core/software/functions.nf +++ b/modules/nf-core/software/functions.nf @@ -29,31 +29,31 @@ def initOptions(Map args) { * Tidy up and join elements of a list to return a path string */ def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') } /* * Function to save/publish module results */ -def saveFiles(filename, options, publish_dir='', publish_id='') { - if (!filename.endsWith('.version.txt')) { - def ioptions = initOptions(options) - def path_list = [ ioptions.publish_dir ?: publish_dir ] +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] if (ioptions.publish_by_id) { - path_list.add(publish_id) + path_list.add(args.publish_id) } if (ioptions.publish_files instanceof Map) { for (ext in ioptions.publish_files) { - if (filename.endsWith(ext.key)) { + if (args.filename.endsWith(ext.key)) { def ext_list = path_list.collect() ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$filename" + return "${getPathFromList(ext_list)}/$args.filename" } } } else { - return "${getPathFromList(path_list)}/$filename" + return "${getPathFromList(path_list)}/$args.filename" } } } diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf index 9958fe75f..6045fc587 100644 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ b/modules/nf-core/software/homer_annotatepeaks.nf @@ -8,7 +8,7 @@ process HOMER_ANNOTATEPEAKS { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/homer:4.11--pl526h9a982cc_2" //container "https://depot.galaxyproject.org/singularity/homer:4.11--pl526h9a982cc_2" diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf index b38efc5c6..83537a6f2 100644 --- a/modules/nf-core/software/macs2_callpeak.nf +++ b/modules/nf-core/software/macs2_callpeak.nf @@ -6,7 +6,7 @@ process MACS2_CALLPEAK { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/macs2:2.2.7.1--py37h516909a_0" //container "https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py37h516909a_0" diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf index 2c164e3a2..88dc6493f 100644 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ b/modules/nf-core/software/phantompeakqualtools.nf @@ -8,7 +8,7 @@ process PHANTOMPEAKQUALTOOLS { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/phantompeakqualtools:1.2.2--0" //container "https://depot.galaxyproject.org/singularity/phantompeakqualtools:1.2.2--0" diff --git a/modules/nf-core/software/picard_collectmultiplemetrics.nf b/modules/nf-core/software/picard_collectmultiplemetrics.nf index acb2a6275..09bdefeda 100644 --- a/modules/nf-core/software/picard_collectmultiplemetrics.nf +++ b/modules/nf-core/software/picard_collectmultiplemetrics.nf @@ -6,7 +6,7 @@ process PICARD_COLLECTMULTIPLEMETRICS { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" diff --git a/modules/nf-core/software/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf index cfbfed58f..7a466324d 100644 --- a/modules/nf-core/software/picard_markduplicates.nf +++ b/modules/nf-core/software/picard_markduplicates.nf @@ -6,7 +6,7 @@ process PICARD_MARKDUPLICATES { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" diff --git a/modules/nf-core/software/picard_mergesamfiles.nf b/modules/nf-core/software/picard_mergesamfiles.nf index f957ddaa2..ca50913a4 100644 --- a/modules/nf-core/software/picard_mergesamfiles.nf +++ b/modules/nf-core/software/picard_mergesamfiles.nf @@ -6,7 +6,7 @@ process PICARD_MERGESAMFILES { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/picard:2.23.2--0" //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" diff --git a/modules/nf-core/software/preseq_lcextrap.nf b/modules/nf-core/software/preseq_lcextrap.nf index ec80e684a..9461acc96 100644 --- a/modules/nf-core/software/preseq_lcextrap.nf +++ b/modules/nf-core/software/preseq_lcextrap.nf @@ -7,7 +7,7 @@ process PRESEQ_LCEXTRAP { label 'error_ignore' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/preseq:2.0.3--hf53bd2b_3" //container "https://depot.galaxyproject.org/singularity/preseq:2.0.3--hf53bd2b_3" diff --git a/modules/nf-core/software/samtools_flagstat.nf b/modules/nf-core/software/samtools_flagstat.nf index d04c205b9..4c14a41ae 100644 --- a/modules/nf-core/software/samtools_flagstat.nf +++ b/modules/nf-core/software/samtools_flagstat.nf @@ -5,7 +5,7 @@ process SAMTOOLS_FLAGSTAT { tag "$meta.id" publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_idxstats.nf b/modules/nf-core/software/samtools_idxstats.nf index 419971e11..9805bb141 100644 --- a/modules/nf-core/software/samtools_idxstats.nf +++ b/modules/nf-core/software/samtools_idxstats.nf @@ -5,7 +5,7 @@ process SAMTOOLS_IDXSTATS { tag "$meta.id" publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_index.nf b/modules/nf-core/software/samtools_index.nf index f8f749fd0..456e2663d 100644 --- a/modules/nf-core/software/samtools_index.nf +++ b/modules/nf-core/software/samtools_index.nf @@ -5,7 +5,7 @@ process SAMTOOLS_INDEX { tag "$meta.id" publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_sort.nf b/modules/nf-core/software/samtools_sort.nf index fca94ef3d..8c038054c 100644 --- a/modules/nf-core/software/samtools_sort.nf +++ b/modules/nf-core/software/samtools_sort.nf @@ -6,7 +6,7 @@ process SAMTOOLS_SORT { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/samtools_stats.nf b/modules/nf-core/software/samtools_stats.nf index 8fbf22e98..52d5e2d74 100644 --- a/modules/nf-core/software/samtools_stats.nf +++ b/modules/nf-core/software/samtools_stats.nf @@ -5,7 +5,7 @@ process SAMTOOLS_STATS { tag "$meta.id" publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/nf-core/software/subread_featurecounts.nf b/modules/nf-core/software/subread_featurecounts.nf index 8e7cc0177..974ae2814 100644 --- a/modules/nf-core/software/subread_featurecounts.nf +++ b/modules/nf-core/software/subread_featurecounts.nf @@ -6,7 +6,7 @@ process SUBREAD_FEATURECOUNTS { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" //container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" diff --git a/modules/nf-core/software/trimgalore.nf b/modules/nf-core/software/trimgalore.nf index a2bcdf6e0..be9b961c3 100644 --- a/modules/nf-core/software/trimgalore.nf +++ b/modules/nf-core/software/trimgalore.nf @@ -6,7 +6,7 @@ process TRIMGALORE { label 'process_high' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/trim-galore:0.6.5--0" //container "https://depot.galaxyproject.org/singularity/trim-galore:0.6.5--0" diff --git a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf index ed9ba99e0..ca12ff0d9 100644 --- a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf +++ b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf @@ -8,7 +8,7 @@ process UCSC_BEDRAPHTOBIGWIG { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/ucsc-bedgraphtobigwig:377--h446ed27_1" //container "https://depot.galaxyproject.org/singularity/ucsc-bedgraphtobigwig:377--h446ed27_1" From 78f1b733af198de5f90ffbe2f5570beafff6e0a8 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 4 Aug 2020 17:00:53 +0100 Subject: [PATCH 137/538] Add def everywhere --- modules/nf-core/software/bwa_mem.nf | 4 ++-- modules/nf-core/software/deeptools_computematrix.nf | 2 +- modules/nf-core/software/deeptools_plotfingerprint.nf | 4 ++-- modules/nf-core/software/deeptools_plotheatmap.nf | 2 +- modules/nf-core/software/fastqc.nf | 2 +- modules/nf-core/software/homer_annotatepeaks.nf | 2 +- modules/nf-core/software/macs2_callpeak.nf | 6 +++--- modules/nf-core/software/phantompeakqualtools.nf | 2 +- .../nf-core/software/picard_collectmultiplemetrics.nf | 6 +++--- modules/nf-core/software/picard_markduplicates.nf | 6 +++--- modules/nf-core/software/picard_mergesamfiles.nf | 8 ++++---- modules/nf-core/software/preseq_lcextrap.nf | 4 ++-- modules/nf-core/software/samtools_sort.nf | 2 +- modules/nf-core/software/subread_featurecounts.nf | 4 ++-- modules/nf-core/software/trimgalore.nf | 10 +++++----- modules/nf-core/software/ucsc_bedgraphtobigwig.nf | 2 +- 16 files changed, 33 insertions(+), 33 deletions(-) diff --git a/modules/nf-core/software/bwa_mem.nf b/modules/nf-core/software/bwa_mem.nf index 1b231240f..127bc7003 100644 --- a/modules/nf-core/software/bwa_mem.nf +++ b/modules/nf-core/software/bwa_mem.nf @@ -26,8 +26,8 @@ process BWA_MEM { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - rg = meta.read_group ? "-R ${meta.read_group}" : "" + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def rg = meta.read_group ? "-R ${meta.read_group}" : "" """ bwa mem \\ $ioptions.args \\ diff --git a/modules/nf-core/software/deeptools_computematrix.nf b/modules/nf-core/software/deeptools_computematrix.nf index 0c505e419..f53662e3e 100644 --- a/modules/nf-core/software/deeptools_computematrix.nf +++ b/modules/nf-core/software/deeptools_computematrix.nf @@ -26,7 +26,7 @@ process DEEPTOOLS_COMPUTEMATRIX { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ computeMatrix \\ $ioptions.args \\ diff --git a/modules/nf-core/software/deeptools_plotfingerprint.nf b/modules/nf-core/software/deeptools_plotfingerprint.nf index 9304e836c..ede8a041a 100644 --- a/modules/nf-core/software/deeptools_plotfingerprint.nf +++ b/modules/nf-core/software/deeptools_plotfingerprint.nf @@ -26,8 +26,8 @@ process DEEPTOOLS_PLOTFINGERPRINT { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - extend = (meta.single_end && params.fragment_size > 0) ? "--extendReads ${params.fragment_size}" : '' + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def extend = (meta.single_end && params.fragment_size > 0) ? "--extendReads ${params.fragment_size}" : '' """ plotFingerprint \\ $ioptions.args \\ diff --git a/modules/nf-core/software/deeptools_plotheatmap.nf b/modules/nf-core/software/deeptools_plotheatmap.nf index 3e8f78d77..9cc740e2d 100644 --- a/modules/nf-core/software/deeptools_plotheatmap.nf +++ b/modules/nf-core/software/deeptools_plotheatmap.nf @@ -25,7 +25,7 @@ process DEEPTOOLS_PLOTHEATMAP { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ plotHeatmap \\ $ioptions.args \\ diff --git a/modules/nf-core/software/fastqc.nf b/modules/nf-core/software/fastqc.nf index 8b66fd360..7f882525e 100644 --- a/modules/nf-core/software/fastqc.nf +++ b/modules/nf-core/software/fastqc.nf @@ -26,7 +26,7 @@ process FASTQC { // Add soft-links to original FastQs for consistent naming in pipeline def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}.${ioptions.suffix}" : "${meta.id}" + def prefix = ioptions.suffix ? "${meta.id}.${ioptions.suffix}" : "${meta.id}" if (meta.single_end) { """ [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf index 6045fc587..496f5cc49 100644 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ b/modules/nf-core/software/homer_annotatepeaks.nf @@ -28,7 +28,7 @@ process HOMER_ANNOTATEPEAKS { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ annotatePeaks.pl \\ $peak \\ diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf index 83537a6f2..454f0fb66 100644 --- a/modules/nf-core/software/macs2_callpeak.nf +++ b/modules/nf-core/software/macs2_callpeak.nf @@ -29,9 +29,9 @@ process MACS2_CALLPEAK { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - format = meta.single_end ? 'BAM' : 'BAMPE' - control = controlbam ? "--control $controlbam" : '' + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def format = meta.single_end ? 'BAM' : 'BAMPE' + def control = controlbam ? "--control $controlbam" : '' """ macs2 \\ callpeak \\ diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf index 88dc6493f..7777e1328 100644 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ b/modules/nf-core/software/phantompeakqualtools.nf @@ -28,7 +28,7 @@ process PHANTOMPEAKQUALTOOLS { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ RUN_SPP=`which run_spp.R` Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus diff --git a/modules/nf-core/software/picard_collectmultiplemetrics.nf b/modules/nf-core/software/picard_collectmultiplemetrics.nf index 09bdefeda..8850d534c 100644 --- a/modules/nf-core/software/picard_collectmultiplemetrics.nf +++ b/modules/nf-core/software/picard_collectmultiplemetrics.nf @@ -24,9 +24,9 @@ process PICARD_COLLECTMULTIPLEMETRICS { path "*.version.txt", emit: version script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" def avail_mem = 3 if (!task.memory) { log.info '[Picard CollectMultipleMetrics] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' diff --git a/modules/nf-core/software/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf index 7a466324d..8bfed2565 100644 --- a/modules/nf-core/software/picard_markduplicates.nf +++ b/modules/nf-core/software/picard_markduplicates.nf @@ -23,9 +23,9 @@ process PICARD_MARKDUPLICATES { path "*.version.txt", emit: version script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" def avail_mem = 3 if (!task.memory) { log.info '[Picard MarkDuplicates] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' diff --git a/modules/nf-core/software/picard_mergesamfiles.nf b/modules/nf-core/software/picard_mergesamfiles.nf index ca50913a4..062bbfc85 100644 --- a/modules/nf-core/software/picard_mergesamfiles.nf +++ b/modules/nf-core/software/picard_mergesamfiles.nf @@ -22,10 +22,10 @@ process PICARD_MERGESAMFILES { path "*.version.txt", emit: version script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - bam_files = bams.sort() + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def bam_files = bams.sort() def avail_mem = 3 if (!task.memory) { log.info '[Picard MergeSamFiles] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' diff --git a/modules/nf-core/software/preseq_lcextrap.nf b/modules/nf-core/software/preseq_lcextrap.nf index 9461acc96..26ed3829f 100644 --- a/modules/nf-core/software/preseq_lcextrap.nf +++ b/modules/nf-core/software/preseq_lcextrap.nf @@ -26,8 +26,8 @@ process PRESEQ_LCEXTRAP { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - pe = meta.single_end ? '' : '-pe' + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def pe = meta.single_end ? '' : '-pe' """ preseq \\ lc_extrap \\ diff --git a/modules/nf-core/software/samtools_sort.nf b/modules/nf-core/software/samtools_sort.nf index 8c038054c..9467e2aea 100644 --- a/modules/nf-core/software/samtools_sort.nf +++ b/modules/nf-core/software/samtools_sort.nf @@ -24,7 +24,7 @@ process SAMTOOLS_SORT { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ samtools sort $ioptions.args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt diff --git a/modules/nf-core/software/subread_featurecounts.nf b/modules/nf-core/software/subread_featurecounts.nf index 974ae2814..e8a9667f3 100644 --- a/modules/nf-core/software/subread_featurecounts.nf +++ b/modules/nf-core/software/subread_featurecounts.nf @@ -25,8 +25,8 @@ process SUBREAD_FEATURECOUNTS { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - pe = meta.single_end ? '' : '-p' + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def pe = meta.single_end ? '' : '-p' """ featureCounts \\ $ioptions.args \\ diff --git a/modules/nf-core/software/trimgalore.nf b/modules/nf-core/software/trimgalore.nf index be9b961c3..219b3e659 100644 --- a/modules/nf-core/software/trimgalore.nf +++ b/modules/nf-core/software/trimgalore.nf @@ -37,15 +37,15 @@ process TRIMGALORE { } // Clipping presets have to be evaluated in the context of SE/PE - c_r1 = params.clip_r1 > 0 ? "--clip_r1 ${params.clip_r1}" : '' - c_r2 = params.clip_r2 > 0 ? "--clip_r2 ${params.clip_r2}" : '' - tpc_r1 = params.three_prime_clip_r1 > 0 ? "--three_prime_clip_r1 ${params.three_prime_clip_r1}" : '' - tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' + def c_r1 = params.clip_r1 > 0 ? "--clip_r1 ${params.clip_r1}" : '' + def c_r2 = params.clip_r2 > 0 ? "--clip_r2 ${params.clip_r2}" : '' + def tpc_r1 = params.three_prime_clip_r1 > 0 ? "--three_prime_clip_r1 ${params.three_prime_clip_r1}" : '' + def tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' // Added soft-links to original fastqs for consistent naming in MultiQC def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" if (meta.single_end) { """ [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz diff --git a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf index ca12ff0d9..4da63fe1f 100644 --- a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf +++ b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf @@ -27,7 +27,7 @@ process UCSC_BEDRAPHTOBIGWIG { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ bedGraphToBigWig $bedgraph $sizes ${prefix}.bigWig echo $VERSION > ${software}.version.txt From 45652afbac053fe1c8ec6cb400c1d8ff7cbaf435 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 4 Aug 2020 17:11:45 +0100 Subject: [PATCH 138/538] Add def everywhere --- modules/local/process/bam_filter.nf | 16 +++++++------- modules/local/process/bam_remove_orphans.nf | 4 ++-- modules/local/process/bedtools_genomecov.nf | 8 +++---- modules/local/process/frip_score.nf | 4 ++-- modules/local/process/functions.nf | 22 +++++++++---------- modules/local/process/get_chrom_sizes.nf | 2 +- .../local/process/get_software_versions.nf | 2 +- modules/local/process/gtf2bed.nf | 2 +- modules/local/process/igv.nf | 2 +- modules/local/process/macs2_consensus.nf | 16 +++++++------- modules/local/process/make_genome_filter.nf | 4 ++-- modules/local/process/multiqc.nf | 14 ++++++------ modules/local/process/multiqc_custom_peaks.nf | 4 ++-- .../multiqc_custom_phantompeakqualtools.nf | 4 ++-- modules/local/process/output_documentation.nf | 2 +- .../local/process/plot_homer_annotatepeaks.nf | 2 +- modules/local/process/plot_macs2_qc.nf | 6 ++--- modules/local/process/samplesheet_check.nf | 2 +- 18 files changed, 58 insertions(+), 58 deletions(-) diff --git a/modules/local/process/bam_filter.nf b/modules/local/process/bam_filter.nf index fd4b6d570..a72f54125 100644 --- a/modules/local/process/bam_filter.nf +++ b/modules/local/process/bam_filter.nf @@ -9,7 +9,7 @@ process BAM_FILTER { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=task.process.toLowerCase(), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:meta.id) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -25,13 +25,13 @@ process BAM_FILTER { path "*.version.txt", emit: version script: - def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - filter_params = meta.single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' - dup_params = params.keep_dups ? '' : '-F 0x0400' - multimap_params = params.keep_multi_map ? '' : '-q 1' - blacklist_params = params.blacklist ? "-L $bed" : '' - config = meta.single_end ? bamtools_filter_se_config : bamtools_filter_pe_config + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def filter_params = meta.single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' + def dup_params = params.keep_dups ? '' : '-F 0x0400' + def multimap_params = params.keep_multi_map ? '' : '-q 1' + def blacklist_params = params.blacklist ? "-L $bed" : '' + def config = meta.single_end ? bamtools_filter_se_config : bamtools_filter_pe_config """ samtools view \\ $filter_params \\ diff --git a/modules/local/process/bam_remove_orphans.nf b/modules/local/process/bam_remove_orphans.nf index de9efc737..d37432e9b 100644 --- a/modules/local/process/bam_remove_orphans.nf +++ b/modules/local/process/bam_remove_orphans.nf @@ -9,7 +9,7 @@ process BAM_REMOVE_ORPHANS { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=task.process.toLowerCase(), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:meta.id) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -22,7 +22,7 @@ process BAM_REMOVE_ORPHANS { script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" if (!meta.single_end) { """ samtools sort -n -@ $task.cpus -o ${prefix}.name.sorted.bam -T ${prefix}.name.sorted $bam diff --git a/modules/local/process/bedtools_genomecov.nf b/modules/local/process/bedtools_genomecov.nf index 9eac32aab..21464e905 100644 --- a/modules/local/process/bedtools_genomecov.nf +++ b/modules/local/process/bedtools_genomecov.nf @@ -6,7 +6,7 @@ process BEDTOOLS_GENOMECOV { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" @@ -25,9 +25,9 @@ process BEDTOOLS_GENOMECOV { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - pe = meta.single_end ? '' : '-pc' - extend = (meta.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def pe = meta.single_end ? '' : '-pc' + def extend = (meta.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' """ SCALE_FACTOR=\$(grep 'mapped (' $flagstat | awk '{print 1000000/\$1}') echo \$SCALE_FACTOR > ${prefix}.scale_factor.txt diff --git a/modules/local/process/frip_score.nf b/modules/local/process/frip_score.nf index 9399851d4..1fd0a7b41 100644 --- a/modules/local/process/frip_score.nf +++ b/modules/local/process/frip_score.nf @@ -6,7 +6,7 @@ process FRIP_SCORE { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=task.process.toLowerCase(), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:meta.id) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -19,7 +19,7 @@ process FRIP_SCORE { script: def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ READS_IN_PEAKS=\$(intersectBed -a $bam -b $peak $ioptions.args | awk -F '\t' '{sum += \$NF} END {print sum}') samtools flagstat $bam > ${bam}.flagstat diff --git a/modules/local/process/functions.nf b/modules/local/process/functions.nf index a2c0d6ce1..75553cdf5 100644 --- a/modules/local/process/functions.nf +++ b/modules/local/process/functions.nf @@ -29,31 +29,31 @@ def initOptions(Map args) { * Tidy up and join elements of a list to return a path string */ def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') } /* * Function to save/publish module results */ -def saveFiles(filename, options, publish_dir='', publish_id='') { - if (!filename.endsWith('.version.txt')) { - def ioptions = initOptions(options) - def path_list = [ ioptions.publish_dir ?: publish_dir ] +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] if (ioptions.publish_by_id) { - path_list.add(publish_id) + path_list.add(args.publish_id) } if (ioptions.publish_files instanceof Map) { for (ext in ioptions.publish_files) { - if (filename.endsWith(ext.key)) { + if (args.filename.endsWith(ext.key)) { def ext_list = path_list.collect() ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$filename" + return "${getPathFromList(ext_list)}/$args.filename" } } } else { - return "${getPathFromList(path_list)}/$filename" + return "${getPathFromList(path_list)}/$args.filename" } } } diff --git a/modules/local/process/get_chrom_sizes.nf b/modules/local/process/get_chrom_sizes.nf index 99e22122b..e929db2d4 100644 --- a/modules/local/process/get_chrom_sizes.nf +++ b/modules/local/process/get_chrom_sizes.nf @@ -8,7 +8,7 @@ process GET_CHROM_SIZES { tag "$fasta" publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir="genome", publish_id='') } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"genome", publish_id:'') } container "quay.io/biocontainers/samtools:1.10--h9402c20_2" //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" diff --git a/modules/local/process/get_software_versions.nf b/modules/local/process/get_software_versions.nf index 1163b2681..db1cab64a 100644 --- a/modules/local/process/get_software_versions.nf +++ b/modules/local/process/get_software_versions.nf @@ -7,7 +7,7 @@ include { saveFiles } from './functions' process GET_SOFTWARE_VERSIONS { publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir="pipeline_info", publish_id='') } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"pipeline_info", publish_id:'') } input: path versions diff --git a/modules/local/process/gtf2bed.nf b/modules/local/process/gtf2bed.nf index 063b220fe..4258b2379 100644 --- a/modules/local/process/gtf2bed.nf +++ b/modules/local/process/gtf2bed.nf @@ -9,7 +9,7 @@ process GTF2BED { label 'process_low' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir="genome", publish_id='') } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"genome", publish_id:'') } container "quay.io/biocontainers/perl:5.26.2" //container "https://depot.galaxyproject.org/singularity/perl:5.26.2" diff --git a/modules/local/process/igv.nf b/modules/local/process/igv.nf index 7e7faca2c..c13aa3503 100644 --- a/modules/local/process/igv.nf +++ b/modules/local/process/igv.nf @@ -7,7 +7,7 @@ include { saveFiles } from './functions' process IGV { publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=task.process.toLowerCase(), publish_id='') } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:'') } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/macs2_consensus.nf b/modules/local/process/macs2_consensus.nf index 18cef6e54..b3ba35ff4 100644 --- a/modules/local/process/macs2_consensus.nf +++ b/modules/local/process/macs2_consensus.nf @@ -9,7 +9,7 @@ process MACS2_CONSENSUS { label 'process_long' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -26,13 +26,13 @@ process MACS2_CONSENSUS { script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ if (meta.multiple_groups || meta.replicates_exist) { - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}.consensus_peaks" : "${meta.id}.consensus_peaks" - peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' - mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') - collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') - expandparam = params.narrow_peak ? '--is_narrow_peak' : '' + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}.consensus_peaks" : "${meta.id}.consensus_peaks" + def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' + def mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') + def collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') + def expandparam = params.narrow_peak ? '--is_narrow_peak' : '' """ sort -T '.' -k1,1 -k2,2n ${peaks.collect{it.toString()}.sort().join(' ')} \\ | mergeBed -c $mergecols -o $collapsecols > ${prefix}.txt diff --git a/modules/local/process/make_genome_filter.nf b/modules/local/process/make_genome_filter.nf index 1910d6f2d..042fcdc49 100644 --- a/modules/local/process/make_genome_filter.nf +++ b/modules/local/process/make_genome_filter.nf @@ -8,7 +8,7 @@ process MAKE_GENOME_FILTER { tag "$sizes" publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir="genome", publish_id='') } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"genome", publish_id:'') } container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" @@ -26,7 +26,7 @@ process MAKE_GENOME_FILTER { script: def software = 'bedtools' - file_out = "${sizes.simpleName}.include_regions.bed" + def file_out = "${sizes.simpleName}.include_regions.bed" if (params.blacklist) { """ sortBed -i $blacklist -g $sizes | complementBed -i stdin -g $sizes > $file_out diff --git a/modules/local/process/multiqc.nf b/modules/local/process/multiqc.nf index f90de009f..3a9865f8e 100644 --- a/modules/local/process/multiqc.nf +++ b/modules/local/process/multiqc.nf @@ -12,7 +12,7 @@ process MULTIQC { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id='') } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:'') } container "quay.io/biocontainers/multiqc:1.9--pyh9f0ad1d_0" //container "https://depot.galaxyproject.org/singularity/multiqc:1.9--pyh9f0ad1d_0" @@ -65,12 +65,12 @@ process MULTIQC { path "*_data", emit: data script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - rtitle = custom_runName ? "--title \"$custom_runName\"" : '' - rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' - custom_config_file = params.multiqc_config ? "--config $mqc_custom_config" : '' + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def rtitle = custom_runName ? "--title \"$custom_runName\"" : '' + def rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' + def custom_config = params.multiqc_config ? "--config $mqc_custom_config" : '' """ - multiqc -f $ioptions.args $rtitle $rfilename $custom_config_file . + multiqc -f $ioptions.args $rtitle $rfilename $custom_config . """ } diff --git a/modules/local/process/multiqc_custom_peaks.nf b/modules/local/process/multiqc_custom_peaks.nf index 8e10a1bd6..0d152242b 100644 --- a/modules/local/process/multiqc_custom_peaks.nf +++ b/modules/local/process/multiqc_custom_peaks.nf @@ -5,7 +5,7 @@ process MULTIQC_CUSTOM_PEAKS { tag "$meta.id" publishDir "${params.outdir} ", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -22,7 +22,7 @@ process MULTIQC_CUSTOM_PEAKS { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ cat $peak | wc -l | awk -v OFS='\t' '{ print "${prefix}", \$1 }' | cat $peak_count_header - > ${prefix}.peak_count_mqc.tsv cat $frip_score_header $frip > ${prefix}.FRiP_mqc.tsv diff --git a/modules/local/process/multiqc_custom_phantompeakqualtools.nf b/modules/local/process/multiqc_custom_phantompeakqualtools.nf index cbd38c255..a49fbf17c 100644 --- a/modules/local/process/multiqc_custom_phantompeakqualtools.nf +++ b/modules/local/process/multiqc_custom_phantompeakqualtools.nf @@ -5,7 +5,7 @@ process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { tag "$meta.id" publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=getSoftwareName(task.process), publish_id=meta.id) } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -24,7 +24,7 @@ process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" """ cp $correlation_header ${prefix}.spp_correlation_mqc.tsv Rscript -e "load('$rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}.spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" diff --git a/modules/local/process/output_documentation.nf b/modules/local/process/output_documentation.nf index a07c9e973..86aaae1bd 100644 --- a/modules/local/process/output_documentation.nf +++ b/modules/local/process/output_documentation.nf @@ -7,7 +7,7 @@ include { saveFiles } from './functions' process OUTPUT_DOCUMENTATION { publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir="pipeline_info", publish_id='') } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"pipeline_info", publish_id:'') } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/plot_homer_annotatepeaks.nf b/modules/local/process/plot_homer_annotatepeaks.nf index 649a0cfd3..c474cfc66 100644 --- a/modules/local/process/plot_homer_annotatepeaks.nf +++ b/modules/local/process/plot_homer_annotatepeaks.nf @@ -8,7 +8,7 @@ process PLOT_HOMER_ANNOTATEPEAKS { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=task.process.toLowerCase(), publish_id='') } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:'') } conda (params.conda ? "${baseDir}/environment.yml" : null) diff --git a/modules/local/process/plot_macs2_qc.nf b/modules/local/process/plot_macs2_qc.nf index d40a8d954..ee3065f03 100644 --- a/modules/local/process/plot_macs2_qc.nf +++ b/modules/local/process/plot_macs2_qc.nf @@ -8,7 +8,7 @@ process PLOT_MACS2_QC { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir=task.process.toLowerCase(), publish_id='') } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:'') } conda (params.conda ? "${baseDir}/environment.yml" : null) @@ -21,8 +21,8 @@ process PLOT_MACS2_QC { path '*.pdf', emit: pdf script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - def ioptions = initOptions(options) - peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' + def ioptions = initOptions(options) + def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' """ plot_macs2_qc.r \\ -i ${peaks.join(',')} \\ diff --git a/modules/local/process/samplesheet_check.nf b/modules/local/process/samplesheet_check.nf index 5c393ed39..c4057e977 100644 --- a/modules/local/process/samplesheet_check.nf +++ b/modules/local/process/samplesheet_check.nf @@ -8,7 +8,7 @@ process SAMPLESHEET_CHECK { tag "$samplesheet" publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename=filename, options=options, publish_dir="pipeline_info", publish_id='') } + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"pipeline_info", publish_id:'') } conda (params.conda ? "${baseDir}/environment.yml" : null) From 67bb690d4a8e7394615df067ef3ec133bd9367d6 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 4 Aug 2020 17:14:28 +0100 Subject: [PATCH 139/538] Update CHANGELOG --- CHANGELOG.md | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index e3168b40b..2a1170ab0 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -8,7 +8,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 ### `Added` * Move template boilerplate code to Groovy `lib/` -* Implement pipeline in DSL 2 +* Implement pipeline in DSL2 +* Update template to tools `1.10.2` ### `Fixed` From 00a431a2659986a6806b6cdb46605a2ff90416e9 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 4 Aug 2020 17:32:03 +0100 Subject: [PATCH 140/538] Remove def because prefix required in output section of process --- modules/local/process/bam_remove_orphans.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/modules/local/process/bam_remove_orphans.nf b/modules/local/process/bam_remove_orphans.nf index d37432e9b..9d6e001ef 100644 --- a/modules/local/process/bam_remove_orphans.nf +++ b/modules/local/process/bam_remove_orphans.nf @@ -22,7 +22,7 @@ process BAM_REMOVE_ORPHANS { script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" if (!meta.single_end) { """ samtools sort -n -@ $task.cpus -o ${prefix}.name.sorted.bam -T ${prefix}.name.sorted $bam From 6d57fd2f97d121525cc473c484d75088e922e57c Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 5 Aug 2020 17:54:44 +0100 Subject: [PATCH 141/538] Remove initial nf-core modules --- modules/nf-core/software/bwa_index.nf | 31 -------- modules/nf-core/software/bwa_mem.nf | 42 ---------- .../software/deeptools_computematrix.nf | 41 ---------- .../software/deeptools_plotfingerprint.nf | 43 ---------- .../nf-core/software/deeptools_plotheatmap.nf | 38 --------- .../nf-core/software/deeptools_plotprofile.nf | 38 --------- modules/nf-core/software/fastqc.nf | 44 ----------- modules/nf-core/software/functions.nf | 59 -------------- .../nf-core/software/homer_annotatepeaks.nf | 43 ---------- modules/nf-core/software/macs2_callpeak.nf | 47 ----------- .../nf-core/software/phantompeakqualtools.nf | 37 --------- .../software/picard_collectmultiplemetrics.nf | 47 ----------- .../nf-core/software/picard_markduplicates.nf | 46 ----------- .../nf-core/software/picard_mergesamfiles.nf | 51 ------------ modules/nf-core/software/preseq_lcextrap.nf | 42 ---------- modules/nf-core/software/samtools_flagstat.nf | 29 ------- modules/nf-core/software/samtools_idxstats.nf | 29 ------- modules/nf-core/software/samtools_index.nf | 29 ------- modules/nf-core/software/samtools_sort.nf | 32 -------- modules/nf-core/software/samtools_stats.nf | 29 ------- .../nf-core/software/subread_featurecounts.nf | 41 ---------- modules/nf-core/software/trimgalore.nf | 79 ------------------- .../nf-core/software/ucsc_bedgraphtobigwig.nf | 35 -------- 23 files changed, 952 deletions(-) delete mode 100644 modules/nf-core/software/bwa_index.nf delete mode 100644 modules/nf-core/software/bwa_mem.nf delete mode 100644 modules/nf-core/software/deeptools_computematrix.nf delete mode 100644 modules/nf-core/software/deeptools_plotfingerprint.nf delete mode 100644 modules/nf-core/software/deeptools_plotheatmap.nf delete mode 100644 modules/nf-core/software/deeptools_plotprofile.nf delete mode 100644 modules/nf-core/software/fastqc.nf delete mode 100644 modules/nf-core/software/functions.nf delete mode 100644 modules/nf-core/software/homer_annotatepeaks.nf delete mode 100644 modules/nf-core/software/macs2_callpeak.nf delete mode 100644 modules/nf-core/software/phantompeakqualtools.nf delete mode 100644 modules/nf-core/software/picard_collectmultiplemetrics.nf delete mode 100644 modules/nf-core/software/picard_markduplicates.nf delete mode 100644 modules/nf-core/software/picard_mergesamfiles.nf delete mode 100644 modules/nf-core/software/preseq_lcextrap.nf delete mode 100644 modules/nf-core/software/samtools_flagstat.nf delete mode 100644 modules/nf-core/software/samtools_idxstats.nf delete mode 100644 modules/nf-core/software/samtools_index.nf delete mode 100644 modules/nf-core/software/samtools_sort.nf delete mode 100644 modules/nf-core/software/samtools_stats.nf delete mode 100644 modules/nf-core/software/subread_featurecounts.nf delete mode 100644 modules/nf-core/software/trimgalore.nf delete mode 100644 modules/nf-core/software/ucsc_bedgraphtobigwig.nf diff --git a/modules/nf-core/software/bwa_index.nf b/modules/nf-core/software/bwa_index.nf deleted file mode 100644 index 38b86c1fb..000000000 --- a/modules/nf-core/software/bwa_index.nf +++ /dev/null @@ -1,31 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process BWA_INDEX { - tag "$fasta" - label 'process_high' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:'') } - - container "biocontainers/bwa:v0.7.17_cv1" - //container "https://depot.galaxyproject.org/singularity/bwa:0.7.17--hed695b0_7" - - conda (params.conda ? "bioconda::bwa=0.7.17" : null) - - input: - path fasta - val options - - output: - path "${fasta}.*", emit: index - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - """ - bwa index $ioptions.args $fasta - echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/bwa_mem.nf b/modules/nf-core/software/bwa_mem.nf deleted file mode 100644 index 127bc7003..000000000 --- a/modules/nf-core/software/bwa_mem.nf +++ /dev/null @@ -1,42 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process BWA_MEM { - tag "$meta.id" - label 'process_high' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" - //container "https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" - - conda (params.conda ? "bioconda::bwa=0.7.17 bioconda::samtools=1.10" : null) - - input: - tuple val(meta), path(reads) - path index - path fasta - val options - - output: - tuple val(meta), path("*.bam"), emit: bam - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - def rg = meta.read_group ? "-R ${meta.read_group}" : "" - """ - bwa mem \\ - $ioptions.args \\ - $rg \\ - -t $task.cpus \\ - $fasta \\ - $reads \\ - | samtools view $ioptions.args2 -@ $task.cpus -bS -o ${prefix}.bam - - - echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/deeptools_computematrix.nf b/modules/nf-core/software/deeptools_computematrix.nf deleted file mode 100644 index f53662e3e..000000000 --- a/modules/nf-core/software/deeptools_computematrix.nf +++ /dev/null @@ -1,41 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process DEEPTOOLS_COMPUTEMATRIX { - tag "$meta.id" - label 'process_high' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/deeptools:3.4.3--py_0" - //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" - - conda (params.conda ? "bioconda::deeptools=3.4.3" : null) - - input: - tuple val(meta), path(bigwig) - path bed - val options - - output: - tuple val(meta), path("*.mat.gz"), emit: matrix - tuple val(meta), path("*.mat.tab"), emit: table - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - """ - computeMatrix \\ - $ioptions.args \\ - --regionsFileName $bed \\ - --scoreFileName $bigwig \\ - --outFileName ${prefix}.computeMatrix.mat.gz \\ - --outFileNameMatrix ${prefix}.computeMatrix.vals.mat.tab \\ - --numberOfProcessors $task.cpus - - computeMatrix --version | sed -e "s/computeMatrix //g" > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/deeptools_plotfingerprint.nf b/modules/nf-core/software/deeptools_plotfingerprint.nf deleted file mode 100644 index ede8a041a..000000000 --- a/modules/nf-core/software/deeptools_plotfingerprint.nf +++ /dev/null @@ -1,43 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process DEEPTOOLS_PLOTFINGERPRINT { - tag "$meta.id" - label 'process_high' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/deeptools:3.4.3--py_0" - //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" - - conda (params.conda ? "bioconda::deeptools=3.4.3" : null) - - input: - tuple val(meta), path(bams), path(bais) - val options - - output: - tuple val(meta), path("*.pdf"), emit: pdf - tuple val(meta), path("*.raw.txt"), emit: matrix - tuple val(meta), path("*.qcmetrics.txt"), emit: metrics - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - def extend = (meta.single_end && params.fragment_size > 0) ? "--extendReads ${params.fragment_size}" : '' - """ - plotFingerprint \\ - $ioptions.args \\ - $extend \\ - --bamfiles ${bams.join(' ')} \\ - --plotFile ${prefix}.plotFingerprint.pdf \\ - --outRawCounts ${prefix}.plotFingerprint.raw.txt \\ - --outQualityMetrics ${prefix}.plotFingerprint.qcmetrics.txt \\ - --numberOfProcessors $task.cpus - - plotFingerprint --version | sed -e "s/plotFingerprint //g" > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/deeptools_plotheatmap.nf b/modules/nf-core/software/deeptools_plotheatmap.nf deleted file mode 100644 index 9cc740e2d..000000000 --- a/modules/nf-core/software/deeptools_plotheatmap.nf +++ /dev/null @@ -1,38 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process DEEPTOOLS_PLOTHEATMAP { - tag "$meta.id" - label 'process_low' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/deeptools:3.4.3--py_0" - //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" - - conda (params.conda ? "bioconda::deeptools=3.4.3" : null) - - input: - tuple val(meta), path(matrix) - val options - - output: - tuple val(meta), path("*.pdf"), emit: pdf - tuple val(meta), path("*.tab"), emit: table - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - """ - plotHeatmap \\ - $ioptions.args \\ - --matrixFile $matrix \\ - --outFileName ${prefix}.plotHeatmap.pdf \\ - --outFileNameMatrix ${prefix}.plotHeatmap.mat.tab - - plotHeatmap --version | sed -e "s/plotHeatmap //g" > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/deeptools_plotprofile.nf b/modules/nf-core/software/deeptools_plotprofile.nf deleted file mode 100644 index a822066b8..000000000 --- a/modules/nf-core/software/deeptools_plotprofile.nf +++ /dev/null @@ -1,38 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process DEEPTOOLS_PLOTPROFILE { - tag "$meta.id" - label 'process_low' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/deeptools:3.4.3--py_0" - //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" - - conda (params.conda ? "bioconda::deeptools=3.4.3" : null) - - input: - tuple val(meta), path(matrix) - val options - - output: - tuple val(meta), path("*.pdf"), emit: pdf - tuple val(meta), path("*.tab"), emit: table - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - """ - plotProfile \\ - $ioptions.args \\ - --matrixFile $matrix \\ - --outFileName ${prefix}.plotProfile.pdf \\ - --outFileNameData ${prefix}.plotProfile.tab - - plotProfile --version | sed -e "s/plotProfile //g" > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/fastqc.nf b/modules/nf-core/software/fastqc.nf deleted file mode 100644 index 7f882525e..000000000 --- a/modules/nf-core/software/fastqc.nf +++ /dev/null @@ -1,44 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process FASTQC { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/fastqc:0.11.9--0" - //container "https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0" - - conda (params.conda ? "bioconda::fastqc=0.11.9" : null) - - input: - tuple val(meta), path(reads) - val options - - output: - tuple val(meta), path("*.html"), emit: html - tuple val(meta), path("*.zip"), emit: zip - path "*.version.txt", emit: version - - script: - // Add soft-links to original FastQs for consistent naming in pipeline - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}.${ioptions.suffix}" : "${meta.id}" - if (meta.single_end) { - """ - [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz - fastqc $ioptions.args --threads $task.cpus ${prefix}.fastq.gz - fastqc --version | sed -e "s/FastQC v//g" > ${software}.version.txt - """ - } else { - """ - [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz - [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz - fastqc $ioptions.args --threads $task.cpus ${prefix}_1.fastq.gz ${prefix}_2.fastq.gz - fastqc --version | sed -e "s/FastQC v//g" > ${software}.version.txt - """ - } -} diff --git a/modules/nf-core/software/functions.nf b/modules/nf-core/software/functions.nf deleted file mode 100644 index 75553cdf5..000000000 --- a/modules/nf-core/software/functions.nf +++ /dev/null @@ -1,59 +0,0 @@ -/* - * ----------------------------------------------------- - * Utility functions used in nf-core DSL2 module files - * ----------------------------------------------------- - */ - -/* - * Extract name of software tool from process name using $task.process - */ -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -/* - * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules - */ -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files ?: null - options.suffix = args.suffix ?: '' - return options -} - -/* - * Tidy up and join elements of a list to return a path string - */ -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -/* - * Function to save/publish module results - */ -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_id) { - path_list.add(args.publish_id) - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} diff --git a/modules/nf-core/software/homer_annotatepeaks.nf b/modules/nf-core/software/homer_annotatepeaks.nf deleted file mode 100644 index 496f5cc49..000000000 --- a/modules/nf-core/software/homer_annotatepeaks.nf +++ /dev/null @@ -1,43 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -def VERSION = '4.11' - -process HOMER_ANNOTATEPEAKS { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/homer:4.11--pl526h9a982cc_2" - //container "https://depot.galaxyproject.org/singularity/homer:4.11--pl526h9a982cc_2" - - conda (params.conda ? "bioconda::homer=4.11" : null) - - input: - tuple val(meta), path(peak) - path fasta - path gtf - val options - - output: - tuple val(meta), path("*annotatePeaks.txt"), emit: txt - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - """ - annotatePeaks.pl \\ - $peak \\ - $fasta \\ - $ioptions.args \\ - -gtf $gtf \\ - -cpu $task.cpus \\ - > ${prefix}.annotatePeaks.txt - - echo $VERSION > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/macs2_callpeak.nf b/modules/nf-core/software/macs2_callpeak.nf deleted file mode 100644 index 454f0fb66..000000000 --- a/modules/nf-core/software/macs2_callpeak.nf +++ /dev/null @@ -1,47 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process MACS2_CALLPEAK { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/macs2:2.2.7.1--py37h516909a_0" - //container "https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py37h516909a_0" - - conda (params.conda ? "bioconda::macs2=2.2.7.1" : null) - - input: - tuple val(meta), path(ipbam), path(controlbam) - val macs2_gsize - val options - - output: - tuple val(meta), path("*.{narrowPeak,broadPeak}"), emit: peak - tuple val(meta), path("*.xls"), emit: xls - tuple val(meta), path("*.gappedPeak"), emit: gapped optional true - tuple val(meta), path("*.bed"), emit: bed optional true - tuple val(meta), path("*.bdg"), emit: bdg optional true - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - def format = meta.single_end ? 'BAM' : 'BAMPE' - def control = controlbam ? "--control $controlbam" : '' - """ - macs2 \\ - callpeak \\ - $ioptions.args \\ - --gsize $macs2_gsize \\ - --format $format \\ - --name $prefix \\ - --treatment $ipbam \\ - $control - - macs2 --version | sed -e "s/macs2 //g" > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/phantompeakqualtools.nf b/modules/nf-core/software/phantompeakqualtools.nf deleted file mode 100644 index 7777e1328..000000000 --- a/modules/nf-core/software/phantompeakqualtools.nf +++ /dev/null @@ -1,37 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -def VERSION = '1.2.2' - -process PHANTOMPEAKQUALTOOLS { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/phantompeakqualtools:1.2.2--0" - //container "https://depot.galaxyproject.org/singularity/phantompeakqualtools:1.2.2--0" - - conda (params.conda ? "bioconda::phantompeakqualtools=1.2.2" : null) - - input: - tuple val(meta), path(bam) - val options - - output: - tuple val(meta), path("*.out"), emit: spp - tuple val(meta), path("*.pdf"), emit: pdf - tuple val(meta), path("*.Rdata"), emit: rdata - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - """ - RUN_SPP=`which run_spp.R` - Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus - echo $VERSION > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/picard_collectmultiplemetrics.nf b/modules/nf-core/software/picard_collectmultiplemetrics.nf deleted file mode 100644 index 8850d534c..000000000 --- a/modules/nf-core/software/picard_collectmultiplemetrics.nf +++ /dev/null @@ -1,47 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process PICARD_COLLECTMULTIPLEMETRICS { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/picard:2.23.2--0" - //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" - - conda (params.conda ? "bioconda::picard=2.23.2" : null) - - input: - tuple val(meta), path(bam) - path fasta - val options - - output: - tuple val(meta), path("*_metrics"), emit: metrics - tuple val(meta), path("*.pdf"), emit: pdf - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - def avail_mem = 3 - if (!task.memory) { - log.info '[Picard CollectMultipleMetrics] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' - } else { - avail_mem = task.memory.giga - } - """ - picard \\ - -Xmx${avail_mem}g \\ - CollectMultipleMetrics \\ - $ioptions.args \\ - INPUT=$bam \\ - OUTPUT=${prefix}.CollectMultipleMetrics \\ - REFERENCE_SEQUENCE=$fasta - - echo \$(picard CollectMultipleMetrics --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/picard_markduplicates.nf b/modules/nf-core/software/picard_markduplicates.nf deleted file mode 100644 index 8bfed2565..000000000 --- a/modules/nf-core/software/picard_markduplicates.nf +++ /dev/null @@ -1,46 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process PICARD_MARKDUPLICATES { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/picard:2.23.2--0" - //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" - - conda (params.conda ? "bioconda::picard=2.23.2" : null) - - input: - tuple val(meta), path(bam) - val options - - output: - tuple val(meta), path("*.bam"), emit: bam - tuple val(meta), path("*.metrics.txt"), emit: metrics - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - def avail_mem = 3 - if (!task.memory) { - log.info '[Picard MarkDuplicates] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' - } else { - avail_mem = task.memory.giga - } - """ - picard \\ - -Xmx${avail_mem}g \\ - MarkDuplicates \\ - $ioptions.args \\ - INPUT=$bam \\ - OUTPUT=${prefix}.bam \\ - METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt - - echo \$(picard MarkDuplicates --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/picard_mergesamfiles.nf b/modules/nf-core/software/picard_mergesamfiles.nf deleted file mode 100644 index 062bbfc85..000000000 --- a/modules/nf-core/software/picard_mergesamfiles.nf +++ /dev/null @@ -1,51 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process PICARD_MERGESAMFILES { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/picard:2.23.2--0" - //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" - - conda (params.conda ? "bioconda::picard=2.23.2" : null) - - input: - tuple val(meta), path(bams) - val options - - output: - tuple val(meta), path("*.bam"), emit: bam - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - def bam_files = bams.sort() - def avail_mem = 3 - if (!task.memory) { - log.info '[Picard MergeSamFiles] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' - } else { - avail_mem = task.memory.giga - } - if (bam_files.size() > 1) { - """ - picard \\ - -Xmx${avail_mem}g \\ - MergeSamFiles \\ - $ioptions.args \\ - ${'INPUT='+bam_files.join(' INPUT=')} \\ - OUTPUT=${prefix}.bam - echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt - """ - } else { - """ - ln -s ${bam_files[0]} ${prefix}.bam - echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt - """ - } -} diff --git a/modules/nf-core/software/preseq_lcextrap.nf b/modules/nf-core/software/preseq_lcextrap.nf deleted file mode 100644 index 26ed3829f..000000000 --- a/modules/nf-core/software/preseq_lcextrap.nf +++ /dev/null @@ -1,42 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process PRESEQ_LCEXTRAP { - tag "$meta.id" - label 'process_medium' - label 'error_ignore' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/preseq:2.0.3--hf53bd2b_3" - //container "https://depot.galaxyproject.org/singularity/preseq:2.0.3--hf53bd2b_3" - - conda (params.conda ? "bioconda::preseq=2.0.3" : null) - - input: - tuple val(meta), path(bam) - val options - - output: - tuple val(meta), path("*.ccurve.txt"), emit: ccurve - tuple val(meta), path("*.log"), emit: log - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - def pe = meta.single_end ? '' : '-pe' - """ - preseq \\ - lc_extrap \\ - $ioptions.args \\ - $pe \\ - -output ${prefix}.ccurve.txt \\ - $bam - cp .command.err ${prefix}.command.log - - echo \$(preseq 2>&1) | sed 's/^.*Version: //; s/Usage:.*\$//' > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/samtools_flagstat.nf b/modules/nf-core/software/samtools_flagstat.nf deleted file mode 100644 index 4c14a41ae..000000000 --- a/modules/nf-core/software/samtools_flagstat.nf +++ /dev/null @@ -1,29 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process SAMTOOLS_FLAGSTAT { - tag "$meta.id" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/samtools:1.10--h9402c20_2" - //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - - conda (params.conda ? "bioconda::samtools=1.10" : null) - - input: - tuple val(meta), path(bam), path(bai) - val options - - output: - tuple val(meta), path("*.flagstat"), emit: flagstat - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - """ - samtools flagstat $bam > ${bam}.flagstat - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/samtools_idxstats.nf b/modules/nf-core/software/samtools_idxstats.nf deleted file mode 100644 index 9805bb141..000000000 --- a/modules/nf-core/software/samtools_idxstats.nf +++ /dev/null @@ -1,29 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process SAMTOOLS_IDXSTATS { - tag "$meta.id" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/samtools:1.10--h9402c20_2" - //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - - conda (params.conda ? "bioconda::samtools=1.10" : null) - - input: - tuple val(meta), path(bam), path(bai) - val options - - output: - tuple val(meta), path("*.idxstats"), emit: idxstats - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - """ - samtools idxstats $bam > ${bam}.idxstats - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/samtools_index.nf b/modules/nf-core/software/samtools_index.nf deleted file mode 100644 index 456e2663d..000000000 --- a/modules/nf-core/software/samtools_index.nf +++ /dev/null @@ -1,29 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process SAMTOOLS_INDEX { - tag "$meta.id" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/samtools:1.10--h9402c20_2" - //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - - conda (params.conda ? "bioconda::samtools=1.10" : null) - - input: - tuple val(meta), path(bam) - val options - - output: - tuple val(meta), path("*.bai"), emit: bai - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - """ - samtools index $bam - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/samtools_sort.nf b/modules/nf-core/software/samtools_sort.nf deleted file mode 100644 index 9467e2aea..000000000 --- a/modules/nf-core/software/samtools_sort.nf +++ /dev/null @@ -1,32 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process SAMTOOLS_SORT { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/samtools:1.10--h9402c20_2" - //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - - conda (params.conda ? "bioconda::samtools=1.10" : null) - - input: - tuple val(meta), path(bam) - val options - - output: - tuple val(meta), path("*.bam"), emit: bam - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - """ - samtools sort $ioptions.args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/samtools_stats.nf b/modules/nf-core/software/samtools_stats.nf deleted file mode 100644 index 52d5e2d74..000000000 --- a/modules/nf-core/software/samtools_stats.nf +++ /dev/null @@ -1,29 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process SAMTOOLS_STATS { - tag "$meta.id" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/samtools:1.10--h9402c20_2" - //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - - conda (params.conda ? "bioconda::samtools=1.10" : null) - - input: - tuple val(meta), path(bam), path(bai) - val options - - output: - tuple val(meta), path("*.stats"), emit: stats - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - """ - samtools stats $bam > ${bam}.stats - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/subread_featurecounts.nf b/modules/nf-core/software/subread_featurecounts.nf deleted file mode 100644 index e8a9667f3..000000000 --- a/modules/nf-core/software/subread_featurecounts.nf +++ /dev/null @@ -1,41 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process SUBREAD_FEATURECOUNTS { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" - //container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" - - conda (params.conda ? "bioconda::subread=2.0.1" : null) - - input: - tuple val(meta), path(bams), path(annotation) - val options - - output: - tuple val(meta), path("*featureCounts.txt"), emit: txt - tuple val(meta), path("*featureCounts.txt.summary"), emit: summary - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - def pe = meta.single_end ? '' : '-p' - """ - featureCounts \\ - $ioptions.args \\ - $pe \\ - -T $task.cpus \\ - -a $annotation \\ - -o ${prefix}.featureCounts.txt \\ - ${bams.join(' ')} - - echo \$(featureCounts -v 2>&1) | sed -e "s/featureCounts v//g" > ${software}.version.txt - """ -} diff --git a/modules/nf-core/software/trimgalore.nf b/modules/nf-core/software/trimgalore.nf deleted file mode 100644 index 219b3e659..000000000 --- a/modules/nf-core/software/trimgalore.nf +++ /dev/null @@ -1,79 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process TRIMGALORE { - tag "$meta.id" - label 'process_high' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/trim-galore:0.6.5--0" - //container "https://depot.galaxyproject.org/singularity/trim-galore:0.6.5--0" - - conda (params.conda ? "bioconda::trim-galore=0.6.5" : null) - - input: - tuple val(meta), path(reads) - val options - - output: - tuple val(meta), path("*.fq.gz"), emit: reads - tuple val(meta), path("*.html"), emit: html optional true - tuple val(meta), path("*.zip"), emit: zip optional true - tuple val(meta), path("*report.txt"), emit: log - path "*.version.txt", emit: version - - script: - // Calculate number of --cores for TrimGalore based on value of task.cpus - // See: https://github.com/FelixKrueger/TrimGalore/blob/master/Changelog.md#version-060-release-on-1-mar-2019 - // See: https://github.com/nf-core/atacseq/pull/65 - def cores = 1 - if (task.cpus) { - cores = (task.cpus as int) - 4 - if (meta.single_end) cores = (task.cpus as int) - 3 - if (cores < 1) cores = 1 - if (cores > 4) cores = 4 - } - - // Clipping presets have to be evaluated in the context of SE/PE - def c_r1 = params.clip_r1 > 0 ? "--clip_r1 ${params.clip_r1}" : '' - def c_r2 = params.clip_r2 > 0 ? "--clip_r2 ${params.clip_r2}" : '' - def tpc_r1 = params.three_prime_clip_r1 > 0 ? "--three_prime_clip_r1 ${params.three_prime_clip_r1}" : '' - def tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' - - // Added soft-links to original fastqs for consistent naming in MultiQC - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - if (meta.single_end) { - """ - [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz - trim_galore \\ - $ioptions.args \\ - --cores $cores \\ - --gzip \\ - $c_r1 \\ - $tpc_r1 \\ - ${prefix}.fastq.gz - echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//' > ${software}.version.txt - """ - } else { - """ - [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz - [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz - trim_galore \\ - $ioptions.args \\ - --cores $cores \\ - --paired \\ - --gzip \\ - $c_r1 \\ - $c_r2 \\ - $tpc_r1 \\ - $tpc_r2 \\ - ${prefix}_1.fastq.gz \\ - ${prefix}_2.fastq.gz - echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//' > ${software}.version.txt - """ - } -} diff --git a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf b/modules/nf-core/software/ucsc_bedgraphtobigwig.nf deleted file mode 100644 index 4da63fe1f..000000000 --- a/modules/nf-core/software/ucsc_bedgraphtobigwig.nf +++ /dev/null @@ -1,35 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -def VERSION = '377' - -process UCSC_BEDRAPHTOBIGWIG { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/ucsc-bedgraphtobigwig:377--h446ed27_1" - //container "https://depot.galaxyproject.org/singularity/ucsc-bedgraphtobigwig:377--h446ed27_1" - - conda (params.conda ? "bioconda::ucsc-bedgraphtobigwig=377" : null) - - input: - tuple val(meta), path(bedgraph) - path sizes - val options - - output: - tuple val(meta), path("*.bigWig"), emit: bigwig - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - """ - bedGraphToBigWig $bedgraph $sizes ${prefix}.bigWig - echo $VERSION > ${software}.version.txt - """ -} From 93034f58a0e3ad46497c053f1ab1e28b97e6fd1c Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 5 Aug 2020 17:54:56 +0100 Subject: [PATCH 142/538] Change module paths --- modules/nf-core/subworkflow/bam_sort_samtools.nf | 4 ++-- modules/nf-core/subworkflow/bam_stats_samtools.nf | 6 +++--- modules/nf-core/subworkflow/map_bwa_mem.nf | 2 +- modules/nf-core/subworkflow/mark_duplicates_picard.nf | 4 ++-- 4 files changed, 8 insertions(+), 8 deletions(-) diff --git a/modules/nf-core/subworkflow/bam_sort_samtools.nf b/modules/nf-core/subworkflow/bam_sort_samtools.nf index c58c23ac7..7c42591cc 100644 --- a/modules/nf-core/subworkflow/bam_sort_samtools.nf +++ b/modules/nf-core/subworkflow/bam_sort_samtools.nf @@ -2,8 +2,8 @@ * Sort, index BAM file and run samtools stats, flagstat and idxstats */ -include { SAMTOOLS_SORT } from '../software/samtools_sort' -include { SAMTOOLS_INDEX } from '../software/samtools_index' +include { SAMTOOLS_SORT } from '../software/samtools/sort' +include { SAMTOOLS_INDEX } from '../software/samtools/index' include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' workflow BAM_SORT_SAMTOOLS { diff --git a/modules/nf-core/subworkflow/bam_stats_samtools.nf b/modules/nf-core/subworkflow/bam_stats_samtools.nf index 9178106b1..c4e55377b 100644 --- a/modules/nf-core/subworkflow/bam_stats_samtools.nf +++ b/modules/nf-core/subworkflow/bam_stats_samtools.nf @@ -2,9 +2,9 @@ * Run SAMtools stats, flagstat and idxstats */ -include { SAMTOOLS_STATS } from '../software/samtools_stats' -include { SAMTOOLS_IDXSTATS } from '../software/samtools_idxstats' -include { SAMTOOLS_FLAGSTAT } from '../software/samtools_flagstat' +include { SAMTOOLS_STATS } from '../software/samtools/stats' +include { SAMTOOLS_IDXSTATS } from '../software/samtools/idxstats' +include { SAMTOOLS_FLAGSTAT } from '../software/samtools/flagstat' workflow BAM_STATS_SAMTOOLS { take: diff --git a/modules/nf-core/subworkflow/map_bwa_mem.nf b/modules/nf-core/subworkflow/map_bwa_mem.nf index 008c2dc3f..92b53260f 100644 --- a/modules/nf-core/subworkflow/map_bwa_mem.nf +++ b/modules/nf-core/subworkflow/map_bwa_mem.nf @@ -2,7 +2,7 @@ * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats */ -include { BWA_MEM } from '../software/bwa_mem' +include { BWA_MEM } from '../software/bwa/mem' include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' workflow MAP_BWA_MEM { diff --git a/modules/nf-core/subworkflow/mark_duplicates_picard.nf b/modules/nf-core/subworkflow/mark_duplicates_picard.nf index 9bec786f3..10ade11e9 100644 --- a/modules/nf-core/subworkflow/mark_duplicates_picard.nf +++ b/modules/nf-core/subworkflow/mark_duplicates_picard.nf @@ -2,8 +2,8 @@ * Picard MarkDuplicates, sort, index BAM file and run samtools stats, flagstat and idxstats */ -include { PICARD_MARKDUPLICATES } from '../software/picard_markduplicates' -include { SAMTOOLS_INDEX } from '../software/samtools_index' +include { PICARD_MARKDUPLICATES } from '../software/picard/markduplicates' +include { SAMTOOLS_INDEX } from '../software/samtools/index' include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' workflow MARK_DUPLICATES_PICARD { From 2dfed396eaacea9bfabe117ea76bb1f89f3a375a Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 5 Aug 2020 17:55:15 +0100 Subject: [PATCH 143/538] Strip whitespace from outdir --- modules/local/process/multiqc_custom_peaks.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/modules/local/process/multiqc_custom_peaks.nf b/modules/local/process/multiqc_custom_peaks.nf index 0d152242b..f98ee9bae 100644 --- a/modules/local/process/multiqc_custom_peaks.nf +++ b/modules/local/process/multiqc_custom_peaks.nf @@ -3,7 +3,7 @@ include { initOptions; saveFiles; getSoftwareName } from './functions' process MULTIQC_CUSTOM_PEAKS { tag "$meta.id" - publishDir "${params.outdir} ", + publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } From f92b2aef2846f1dec634c96b6bc157b51d059779 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 5 Aug 2020 17:57:08 +0100 Subject: [PATCH 144/538] Change module paths --- main.nf | 24 ++++++++++++------------ 1 file changed, 12 insertions(+), 12 deletions(-) diff --git a/main.nf b/main.nf index 114dac5ec..8970be09f 100755 --- a/main.nf +++ b/main.nf @@ -155,20 +155,20 @@ include { BAM_CLEAN } from './modules/local/subworkflo /* -- IMPORT NF-CORE MODULES/SUBWORKFLOWS -- */ //////////////////////////////////////////////////// -include { BWA_INDEX } from './modules/nf-core/software/bwa_index' -include { PICARD_MERGESAMFILES } from './modules/nf-core/software/picard_mergesamfiles' -include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/software/picard_collectmultiplemetrics' -include { PRESEQ_LCEXTRAP } from './modules/nf-core/software/preseq_lcextrap' -include { UCSC_BEDRAPHTOBIGWIG } from './modules/nf-core/software/ucsc_bedgraphtobigwig' -include { DEEPTOOLS_COMPUTEMATRIX } from './modules/nf-core/software/deeptools_computematrix' -include { DEEPTOOLS_PLOTPROFILE } from './modules/nf-core/software/deeptools_plotprofile' -include { DEEPTOOLS_PLOTHEATMAP } from './modules/nf-core/software/deeptools_plotheatmap' -include { DEEPTOOLS_PLOTFINGERPRINT } from './modules/nf-core/software/deeptools_plotfingerprint' +include { BWA_INDEX } from './modules/nf-core/software/bwa/index' +include { PICARD_MERGESAMFILES } from './modules/nf-core/software/picard/mergesamfiles' +include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/software/picard/collectmultiplemetrics' +include { PRESEQ_LCEXTRAP } from './modules/nf-core/software/preseq/lcextrap' +include { UCSC_BEDRAPHTOBIGWIG } from './modules/nf-core/software/ucsc/bedgraphtobigwig' +include { DEEPTOOLS_COMPUTEMATRIX } from './modules/nf-core/software/deeptools/computematrix' +include { DEEPTOOLS_PLOTPROFILE } from './modules/nf-core/software/deeptools/plotprofile' +include { DEEPTOOLS_PLOTHEATMAP } from './modules/nf-core/software/deeptools/plotheatmap' +include { DEEPTOOLS_PLOTFINGERPRINT } from './modules/nf-core/software/deeptools/plotfingerprint' include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/software/phantompeakqualtools' -include { MACS2_CALLPEAK } from './modules/nf-core/software/macs2_callpeak' +include { MACS2_CALLPEAK } from './modules/nf-core/software/macs2/callpeak' include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 - HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from './modules/nf-core/software/homer_annotatepeaks' -include { SUBREAD_FEATURECOUNTS } from './modules/nf-core/software/subread_featurecounts' + HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from './modules/nf-core/software/homer/annotatepeaks' +include { SUBREAD_FEATURECOUNTS } from './modules/nf-core/software/subread/featurecounts' include { FASTQC_TRIMGALORE } from './modules/nf-core/subworkflow/fastqc_trimgalore' include { MAP_BWA_MEM } from './modules/nf-core/subworkflow/map_bwa_mem' From 94c50f4b378293846a9c85dfd1b2966ee9fbc276 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 5 Aug 2020 18:02:08 +0100 Subject: [PATCH 145/538] First time installing directly from nf-core modules --- .../nf-core/software/bwa/index/functions.nf | 1 + modules/nf-core/software/bwa/index/main.nf | 31 ++++++++ modules/nf-core/software/bwa/index/meta.yml | 25 ++++++ modules/nf-core/software/bwa/mem/functions.nf | 1 + modules/nf-core/software/bwa/mem/main.nf | 42 ++++++++++ modules/nf-core/software/bwa/mem/meta.yml | 42 ++++++++++ .../deeptools/computematrix/functions.nf | 1 + .../software/deeptools/computematrix/main.nf | 41 ++++++++++ .../deeptools/plotfingerprint/functions.nf | 1 + .../deeptools/plotfingerprint/main.nf | 43 ++++++++++ .../deeptools/plotheatmap/functions.nf | 1 + .../software/deeptools/plotheatmap/main.nf | 38 +++++++++ .../deeptools/plotprofile/functions.nf | 1 + .../software/deeptools/plotprofile/main.nf | 38 +++++++++ modules/nf-core/software/fastqc/functions.nf | 1 + modules/nf-core/software/fastqc/main.nf | 44 +++++++++++ modules/nf-core/software/fastqc/meta.yml | 63 +++++++++++++++ .../software/homer/annotatepeaks/functions.nf | 1 + .../software/homer/annotatepeaks/main.nf | 43 ++++++++++ .../software/macs2/callpeak/functions.nf | 1 + .../nf-core/software/macs2/callpeak/main.nf | 47 +++++++++++ .../phantompeakqualtools/functions.nf | 1 + .../software/phantompeakqualtools/main.nf | 37 +++++++++ .../collectmultiplemetrics/functions.nf | 1 + .../picard/collectmultiplemetrics/main.nf | 47 +++++++++++ .../picard/markduplicates/functions.nf | 1 + .../software/picard/markduplicates/main.nf | 46 +++++++++++ .../picard/mergesamfiles/functions.nf | 1 + .../software/picard/mergesamfiles/main.nf | 51 ++++++++++++ .../software/preseq/lcextrap/functions.nf | 1 + .../nf-core/software/preseq/lcextrap/main.nf | 42 ++++++++++ .../software/samtools/flagstat/functions.nf | 1 + .../software/samtools/flagstat/main.nf | 29 +++++++ .../software/samtools/idxstats/functions.nf | 1 + .../software/samtools/idxstats/main.nf | 29 +++++++ .../software/samtools/index/functions.nf | 1 + .../nf-core/software/samtools/index/main.nf | 29 +++++++ .../nf-core/software/samtools/index/meta.yml | 27 +++++++ .../software/samtools/sort/functions.nf | 1 + .../nf-core/software/samtools/sort/main.nf | 32 ++++++++ .../nf-core/software/samtools/sort/meta.yml | 27 +++++++ .../software/samtools/stats/functions.nf | 1 + .../nf-core/software/samtools/stats/main.nf | 29 +++++++ .../subread/featurecounts/functions.nf | 1 + .../software/subread/featurecounts/main.nf | 41 ++++++++++ .../nf-core/software/trimgalore/functions.nf | 1 + modules/nf-core/software/trimgalore/main.nf | 79 +++++++++++++++++++ modules/nf-core/software/trimgalore/meta.yml | 40 ++++++++++ .../ucsc/bedgraphtobigwig/functions.nf | 1 + .../software/ucsc/bedgraphtobigwig/main.nf | 35 ++++++++ 50 files changed, 1139 insertions(+) create mode 100644 modules/nf-core/software/bwa/index/functions.nf create mode 100644 modules/nf-core/software/bwa/index/main.nf create mode 100644 modules/nf-core/software/bwa/index/meta.yml create mode 100644 modules/nf-core/software/bwa/mem/functions.nf create mode 100644 modules/nf-core/software/bwa/mem/main.nf create mode 100644 modules/nf-core/software/bwa/mem/meta.yml create mode 100644 modules/nf-core/software/deeptools/computematrix/functions.nf create mode 100644 modules/nf-core/software/deeptools/computematrix/main.nf create mode 100644 modules/nf-core/software/deeptools/plotfingerprint/functions.nf create mode 100644 modules/nf-core/software/deeptools/plotfingerprint/main.nf create mode 100644 modules/nf-core/software/deeptools/plotheatmap/functions.nf create mode 100644 modules/nf-core/software/deeptools/plotheatmap/main.nf create mode 100644 modules/nf-core/software/deeptools/plotprofile/functions.nf create mode 100644 modules/nf-core/software/deeptools/plotprofile/main.nf create mode 100644 modules/nf-core/software/fastqc/functions.nf create mode 100644 modules/nf-core/software/fastqc/main.nf create mode 100644 modules/nf-core/software/fastqc/meta.yml create mode 100644 modules/nf-core/software/homer/annotatepeaks/functions.nf create mode 100644 modules/nf-core/software/homer/annotatepeaks/main.nf create mode 100644 modules/nf-core/software/macs2/callpeak/functions.nf create mode 100644 modules/nf-core/software/macs2/callpeak/main.nf create mode 100644 modules/nf-core/software/phantompeakqualtools/functions.nf create mode 100644 modules/nf-core/software/phantompeakqualtools/main.nf create mode 100644 modules/nf-core/software/picard/collectmultiplemetrics/functions.nf create mode 100644 modules/nf-core/software/picard/collectmultiplemetrics/main.nf create mode 100644 modules/nf-core/software/picard/markduplicates/functions.nf create mode 100644 modules/nf-core/software/picard/markduplicates/main.nf create mode 100644 modules/nf-core/software/picard/mergesamfiles/functions.nf create mode 100644 modules/nf-core/software/picard/mergesamfiles/main.nf create mode 100644 modules/nf-core/software/preseq/lcextrap/functions.nf create mode 100644 modules/nf-core/software/preseq/lcextrap/main.nf create mode 100644 modules/nf-core/software/samtools/flagstat/functions.nf create mode 100644 modules/nf-core/software/samtools/flagstat/main.nf create mode 100644 modules/nf-core/software/samtools/idxstats/functions.nf create mode 100644 modules/nf-core/software/samtools/idxstats/main.nf create mode 100644 modules/nf-core/software/samtools/index/functions.nf create mode 100644 modules/nf-core/software/samtools/index/main.nf create mode 100644 modules/nf-core/software/samtools/index/meta.yml create mode 100644 modules/nf-core/software/samtools/sort/functions.nf create mode 100644 modules/nf-core/software/samtools/sort/main.nf create mode 100644 modules/nf-core/software/samtools/sort/meta.yml create mode 100644 modules/nf-core/software/samtools/stats/functions.nf create mode 100644 modules/nf-core/software/samtools/stats/main.nf create mode 100644 modules/nf-core/software/subread/featurecounts/functions.nf create mode 100644 modules/nf-core/software/subread/featurecounts/main.nf create mode 100644 modules/nf-core/software/trimgalore/functions.nf create mode 100644 modules/nf-core/software/trimgalore/main.nf create mode 100644 modules/nf-core/software/trimgalore/meta.yml create mode 100644 modules/nf-core/software/ucsc/bedgraphtobigwig/functions.nf create mode 100644 modules/nf-core/software/ucsc/bedgraphtobigwig/main.nf diff --git a/modules/nf-core/software/bwa/index/functions.nf b/modules/nf-core/software/bwa/index/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/bwa/index/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/bwa/index/main.nf b/modules/nf-core/software/bwa/index/main.nf new file mode 100644 index 000000000..38b86c1fb --- /dev/null +++ b/modules/nf-core/software/bwa/index/main.nf @@ -0,0 +1,31 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process BWA_INDEX { + tag "$fasta" + label 'process_high' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:'') } + + container "biocontainers/bwa:v0.7.17_cv1" + //container "https://depot.galaxyproject.org/singularity/bwa:0.7.17--hed695b0_7" + + conda (params.conda ? "bioconda::bwa=0.7.17" : null) + + input: + path fasta + val options + + output: + path "${fasta}.*", emit: index + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + """ + bwa index $ioptions.args $fasta + echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/bwa/index/meta.yml b/modules/nf-core/software/bwa/index/meta.yml new file mode 100644 index 000000000..49fa3c44d --- /dev/null +++ b/modules/nf-core/software/bwa/index/meta.yml @@ -0,0 +1,25 @@ +name: bwa index +description: create indexes for BWA from a fasta file +keywords: + - index +tools: + - bwa: + description: | + BWA is a software package for mapping DNA sequences against a large reference genome, such as the human genome. + homepage: http://bio-bwa.sourceforge.net/ + documentation: http://www.htslib.org/doc/samtools.html + arxiv: arXiv:1303.3997 +input: + - + - input: + type: file + description: Input fasta file + pattern: "*.{fasta,fa}" +output: + - + - index: + type: file + description: bwa indexes file + pattern: "*.{fasta,fa}.{amb,ann,bwt,pac,sa}" +authors: + - "@maxulysse" diff --git a/modules/nf-core/software/bwa/mem/functions.nf b/modules/nf-core/software/bwa/mem/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/bwa/mem/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/bwa/mem/main.nf b/modules/nf-core/software/bwa/mem/main.nf new file mode 100644 index 000000000..127bc7003 --- /dev/null +++ b/modules/nf-core/software/bwa/mem/main.nf @@ -0,0 +1,42 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process BWA_MEM { + tag "$meta.id" + label 'process_high' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" + //container "https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" + + conda (params.conda ? "bioconda::bwa=0.7.17 bioconda::samtools=1.10" : null) + + input: + tuple val(meta), path(reads) + path index + path fasta + val options + + output: + tuple val(meta), path("*.bam"), emit: bam + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def rg = meta.read_group ? "-R ${meta.read_group}" : "" + """ + bwa mem \\ + $ioptions.args \\ + $rg \\ + -t $task.cpus \\ + $fasta \\ + $reads \\ + | samtools view $ioptions.args2 -@ $task.cpus -bS -o ${prefix}.bam - + + echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/bwa/mem/meta.yml b/modules/nf-core/software/bwa/mem/meta.yml new file mode 100644 index 000000000..d8ae9a7da --- /dev/null +++ b/modules/nf-core/software/bwa/mem/meta.yml @@ -0,0 +1,42 @@ +name: bwa mem +description: Performs fastq alignment to a fasta reference using the burrows-wheeler aligner +keywords: + - mem + - bwa + - alignment +tools: + - bwa: + description: | + BWA is a software package for mapping DNA sequences against a large reference genome, such as the human genome. + homepage: http://bio-bwa.sourceforge.net/ + documentation: http://www.htslib.org/doc/samtools.html + arxiv: arXiv:1303.3997 +input: + - + - id: + type: val + description: read/read pair id + - reads: + type: file + description: Input fastq file + pattern: "*.{fastq,fq}" + - index: + type: file + description: bwa indexes file + pattern: "*.{amb,ann,bwt,pac,sa}" + - prefix: + type: val + description: bwa index prefix, equivalent to index file names without extensions. Usually the reference genome file name unless otherwise specified. +output: + - + - bam: + type: file + description: Output bam file + pattern: "*.bam" + - bamindex: + type: file + description: Output bam index file + pattern: "*.bai" + +authors: + - "@jeremy1805" diff --git a/modules/nf-core/software/deeptools/computematrix/functions.nf b/modules/nf-core/software/deeptools/computematrix/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/deeptools/computematrix/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/deeptools/computematrix/main.nf b/modules/nf-core/software/deeptools/computematrix/main.nf new file mode 100644 index 000000000..f53662e3e --- /dev/null +++ b/modules/nf-core/software/deeptools/computematrix/main.nf @@ -0,0 +1,41 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process DEEPTOOLS_COMPUTEMATRIX { + tag "$meta.id" + label 'process_high' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/deeptools:3.4.3--py_0" + //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" + + conda (params.conda ? "bioconda::deeptools=3.4.3" : null) + + input: + tuple val(meta), path(bigwig) + path bed + val options + + output: + tuple val(meta), path("*.mat.gz"), emit: matrix + tuple val(meta), path("*.mat.tab"), emit: table + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + """ + computeMatrix \\ + $ioptions.args \\ + --regionsFileName $bed \\ + --scoreFileName $bigwig \\ + --outFileName ${prefix}.computeMatrix.mat.gz \\ + --outFileNameMatrix ${prefix}.computeMatrix.vals.mat.tab \\ + --numberOfProcessors $task.cpus + + computeMatrix --version | sed -e "s/computeMatrix //g" > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/deeptools/plotfingerprint/functions.nf b/modules/nf-core/software/deeptools/plotfingerprint/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/deeptools/plotfingerprint/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/deeptools/plotfingerprint/main.nf b/modules/nf-core/software/deeptools/plotfingerprint/main.nf new file mode 100644 index 000000000..ede8a041a --- /dev/null +++ b/modules/nf-core/software/deeptools/plotfingerprint/main.nf @@ -0,0 +1,43 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process DEEPTOOLS_PLOTFINGERPRINT { + tag "$meta.id" + label 'process_high' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/deeptools:3.4.3--py_0" + //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" + + conda (params.conda ? "bioconda::deeptools=3.4.3" : null) + + input: + tuple val(meta), path(bams), path(bais) + val options + + output: + tuple val(meta), path("*.pdf"), emit: pdf + tuple val(meta), path("*.raw.txt"), emit: matrix + tuple val(meta), path("*.qcmetrics.txt"), emit: metrics + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def extend = (meta.single_end && params.fragment_size > 0) ? "--extendReads ${params.fragment_size}" : '' + """ + plotFingerprint \\ + $ioptions.args \\ + $extend \\ + --bamfiles ${bams.join(' ')} \\ + --plotFile ${prefix}.plotFingerprint.pdf \\ + --outRawCounts ${prefix}.plotFingerprint.raw.txt \\ + --outQualityMetrics ${prefix}.plotFingerprint.qcmetrics.txt \\ + --numberOfProcessors $task.cpus + + plotFingerprint --version | sed -e "s/plotFingerprint //g" > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/deeptools/plotheatmap/functions.nf b/modules/nf-core/software/deeptools/plotheatmap/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/deeptools/plotheatmap/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/deeptools/plotheatmap/main.nf b/modules/nf-core/software/deeptools/plotheatmap/main.nf new file mode 100644 index 000000000..9cc740e2d --- /dev/null +++ b/modules/nf-core/software/deeptools/plotheatmap/main.nf @@ -0,0 +1,38 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process DEEPTOOLS_PLOTHEATMAP { + tag "$meta.id" + label 'process_low' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/deeptools:3.4.3--py_0" + //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" + + conda (params.conda ? "bioconda::deeptools=3.4.3" : null) + + input: + tuple val(meta), path(matrix) + val options + + output: + tuple val(meta), path("*.pdf"), emit: pdf + tuple val(meta), path("*.tab"), emit: table + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + """ + plotHeatmap \\ + $ioptions.args \\ + --matrixFile $matrix \\ + --outFileName ${prefix}.plotHeatmap.pdf \\ + --outFileNameMatrix ${prefix}.plotHeatmap.mat.tab + + plotHeatmap --version | sed -e "s/plotHeatmap //g" > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/deeptools/plotprofile/functions.nf b/modules/nf-core/software/deeptools/plotprofile/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/deeptools/plotprofile/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/deeptools/plotprofile/main.nf b/modules/nf-core/software/deeptools/plotprofile/main.nf new file mode 100644 index 000000000..a822066b8 --- /dev/null +++ b/modules/nf-core/software/deeptools/plotprofile/main.nf @@ -0,0 +1,38 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process DEEPTOOLS_PLOTPROFILE { + tag "$meta.id" + label 'process_low' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/deeptools:3.4.3--py_0" + //container "https://depot.galaxyproject.org/singularity/deeptools:3.4.3--py_0" + + conda (params.conda ? "bioconda::deeptools=3.4.3" : null) + + input: + tuple val(meta), path(matrix) + val options + + output: + tuple val(meta), path("*.pdf"), emit: pdf + tuple val(meta), path("*.tab"), emit: table + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + """ + plotProfile \\ + $ioptions.args \\ + --matrixFile $matrix \\ + --outFileName ${prefix}.plotProfile.pdf \\ + --outFileNameData ${prefix}.plotProfile.tab + + plotProfile --version | sed -e "s/plotProfile //g" > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/fastqc/functions.nf b/modules/nf-core/software/fastqc/functions.nf new file mode 100644 index 000000000..dcda375c2 --- /dev/null +++ b/modules/nf-core/software/fastqc/functions.nf @@ -0,0 +1 @@ +../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/fastqc/main.nf b/modules/nf-core/software/fastqc/main.nf new file mode 100644 index 000000000..7f882525e --- /dev/null +++ b/modules/nf-core/software/fastqc/main.nf @@ -0,0 +1,44 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process FASTQC { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/fastqc:0.11.9--0" + //container "https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0" + + conda (params.conda ? "bioconda::fastqc=0.11.9" : null) + + input: + tuple val(meta), path(reads) + val options + + output: + tuple val(meta), path("*.html"), emit: html + tuple val(meta), path("*.zip"), emit: zip + path "*.version.txt", emit: version + + script: + // Add soft-links to original FastQs for consistent naming in pipeline + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}.${ioptions.suffix}" : "${meta.id}" + if (meta.single_end) { + """ + [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz + fastqc $ioptions.args --threads $task.cpus ${prefix}.fastq.gz + fastqc --version | sed -e "s/FastQC v//g" > ${software}.version.txt + """ + } else { + """ + [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz + [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz + fastqc $ioptions.args --threads $task.cpus ${prefix}_1.fastq.gz ${prefix}_2.fastq.gz + fastqc --version | sed -e "s/FastQC v//g" > ${software}.version.txt + """ + } +} diff --git a/modules/nf-core/software/fastqc/meta.yml b/modules/nf-core/software/fastqc/meta.yml new file mode 100644 index 000000000..fcbfeab30 --- /dev/null +++ b/modules/nf-core/software/fastqc/meta.yml @@ -0,0 +1,63 @@ +name: FastQC +description: Run FastQC on sequenced reads +keywords: + - Quality Control + - QC + - Adapters +tools: + - fastqc: + description: | + FastQC gives general quality metrics about your reads. + It provides information about the quality score distribution + across your reads, the per base sequence content (%A/C/G/T). + You get information about adapter contamination and other + overrepresented sequences. + homepage: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/ + documentation: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/ +params: + - fastqc_args: + type: string + description: Additional command line arguments passed to fastqc. + - out_dir: + type: string + description: | + The pipeline's output directory. By default, the module will + output files into `$out_dir/MODULE_NAME` + - publish_dir: + type: string + description: | + Append to the path for the standard output directory provided by `$out_dir`. + - publish_dir_mode: + type: string + description: | + Provide a value for the Nextflow `publishDir` mode parameter + (e.g. copy, link, ...) + - publish_results: + type: string + description: | + Whether or not to publish results into `publish_dir`. Set to `none` to not + publish any files at all; to `default` to publish all relevant files. +input: + - name: + type: string + description: Sample identifier + - single_end: + type: boolean + description: | + Boolean indicating whether the corresponding sample is single-end (true) + or paired-end (false). + - reads: + type: file + description: | + List of input FastQ files of size 1 and 2 for single-end and paired-end data, + respectively. +output: + - report: + type: file + description: FastQC report + pattern: "*_fastqc.{zip,html}" +authors: + - "@grst" + - "@drpatelh" + - "@ewels" + - "@FelixKrueger" diff --git a/modules/nf-core/software/homer/annotatepeaks/functions.nf b/modules/nf-core/software/homer/annotatepeaks/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/homer/annotatepeaks/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/homer/annotatepeaks/main.nf b/modules/nf-core/software/homer/annotatepeaks/main.nf new file mode 100644 index 000000000..496f5cc49 --- /dev/null +++ b/modules/nf-core/software/homer/annotatepeaks/main.nf @@ -0,0 +1,43 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +def VERSION = '4.11' + +process HOMER_ANNOTATEPEAKS { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/homer:4.11--pl526h9a982cc_2" + //container "https://depot.galaxyproject.org/singularity/homer:4.11--pl526h9a982cc_2" + + conda (params.conda ? "bioconda::homer=4.11" : null) + + input: + tuple val(meta), path(peak) + path fasta + path gtf + val options + + output: + tuple val(meta), path("*annotatePeaks.txt"), emit: txt + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + """ + annotatePeaks.pl \\ + $peak \\ + $fasta \\ + $ioptions.args \\ + -gtf $gtf \\ + -cpu $task.cpus \\ + > ${prefix}.annotatePeaks.txt + + echo $VERSION > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/macs2/callpeak/functions.nf b/modules/nf-core/software/macs2/callpeak/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/macs2/callpeak/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/macs2/callpeak/main.nf b/modules/nf-core/software/macs2/callpeak/main.nf new file mode 100644 index 000000000..454f0fb66 --- /dev/null +++ b/modules/nf-core/software/macs2/callpeak/main.nf @@ -0,0 +1,47 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process MACS2_CALLPEAK { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/macs2:2.2.7.1--py37h516909a_0" + //container "https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py37h516909a_0" + + conda (params.conda ? "bioconda::macs2=2.2.7.1" : null) + + input: + tuple val(meta), path(ipbam), path(controlbam) + val macs2_gsize + val options + + output: + tuple val(meta), path("*.{narrowPeak,broadPeak}"), emit: peak + tuple val(meta), path("*.xls"), emit: xls + tuple val(meta), path("*.gappedPeak"), emit: gapped optional true + tuple val(meta), path("*.bed"), emit: bed optional true + tuple val(meta), path("*.bdg"), emit: bdg optional true + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def format = meta.single_end ? 'BAM' : 'BAMPE' + def control = controlbam ? "--control $controlbam" : '' + """ + macs2 \\ + callpeak \\ + $ioptions.args \\ + --gsize $macs2_gsize \\ + --format $format \\ + --name $prefix \\ + --treatment $ipbam \\ + $control + + macs2 --version | sed -e "s/macs2 //g" > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/phantompeakqualtools/functions.nf b/modules/nf-core/software/phantompeakqualtools/functions.nf new file mode 100644 index 000000000..dcda375c2 --- /dev/null +++ b/modules/nf-core/software/phantompeakqualtools/functions.nf @@ -0,0 +1 @@ +../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/phantompeakqualtools/main.nf b/modules/nf-core/software/phantompeakqualtools/main.nf new file mode 100644 index 000000000..7777e1328 --- /dev/null +++ b/modules/nf-core/software/phantompeakqualtools/main.nf @@ -0,0 +1,37 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +def VERSION = '1.2.2' + +process PHANTOMPEAKQUALTOOLS { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/phantompeakqualtools:1.2.2--0" + //container "https://depot.galaxyproject.org/singularity/phantompeakqualtools:1.2.2--0" + + conda (params.conda ? "bioconda::phantompeakqualtools=1.2.2" : null) + + input: + tuple val(meta), path(bam) + val options + + output: + tuple val(meta), path("*.out"), emit: spp + tuple val(meta), path("*.pdf"), emit: pdf + tuple val(meta), path("*.Rdata"), emit: rdata + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + """ + RUN_SPP=`which run_spp.R` + Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus + echo $VERSION > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/picard/collectmultiplemetrics/functions.nf b/modules/nf-core/software/picard/collectmultiplemetrics/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/picard/collectmultiplemetrics/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/picard/collectmultiplemetrics/main.nf b/modules/nf-core/software/picard/collectmultiplemetrics/main.nf new file mode 100644 index 000000000..8850d534c --- /dev/null +++ b/modules/nf-core/software/picard/collectmultiplemetrics/main.nf @@ -0,0 +1,47 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process PICARD_COLLECTMULTIPLEMETRICS { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/picard:2.23.2--0" + //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" + + conda (params.conda ? "bioconda::picard=2.23.2" : null) + + input: + tuple val(meta), path(bam) + path fasta + val options + + output: + tuple val(meta), path("*_metrics"), emit: metrics + tuple val(meta), path("*.pdf"), emit: pdf + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def avail_mem = 3 + if (!task.memory) { + log.info '[Picard CollectMultipleMetrics] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' + } else { + avail_mem = task.memory.giga + } + """ + picard \\ + -Xmx${avail_mem}g \\ + CollectMultipleMetrics \\ + $ioptions.args \\ + INPUT=$bam \\ + OUTPUT=${prefix}.CollectMultipleMetrics \\ + REFERENCE_SEQUENCE=$fasta + + echo \$(picard CollectMultipleMetrics --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/picard/markduplicates/functions.nf b/modules/nf-core/software/picard/markduplicates/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/picard/markduplicates/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/picard/markduplicates/main.nf b/modules/nf-core/software/picard/markduplicates/main.nf new file mode 100644 index 000000000..8bfed2565 --- /dev/null +++ b/modules/nf-core/software/picard/markduplicates/main.nf @@ -0,0 +1,46 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process PICARD_MARKDUPLICATES { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/picard:2.23.2--0" + //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" + + conda (params.conda ? "bioconda::picard=2.23.2" : null) + + input: + tuple val(meta), path(bam) + val options + + output: + tuple val(meta), path("*.bam"), emit: bam + tuple val(meta), path("*.metrics.txt"), emit: metrics + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def avail_mem = 3 + if (!task.memory) { + log.info '[Picard MarkDuplicates] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' + } else { + avail_mem = task.memory.giga + } + """ + picard \\ + -Xmx${avail_mem}g \\ + MarkDuplicates \\ + $ioptions.args \\ + INPUT=$bam \\ + OUTPUT=${prefix}.bam \\ + METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt + + echo \$(picard MarkDuplicates --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/picard/mergesamfiles/functions.nf b/modules/nf-core/software/picard/mergesamfiles/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/picard/mergesamfiles/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/picard/mergesamfiles/main.nf b/modules/nf-core/software/picard/mergesamfiles/main.nf new file mode 100644 index 000000000..062bbfc85 --- /dev/null +++ b/modules/nf-core/software/picard/mergesamfiles/main.nf @@ -0,0 +1,51 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process PICARD_MERGESAMFILES { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/picard:2.23.2--0" + //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" + + conda (params.conda ? "bioconda::picard=2.23.2" : null) + + input: + tuple val(meta), path(bams) + val options + + output: + tuple val(meta), path("*.bam"), emit: bam + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def bam_files = bams.sort() + def avail_mem = 3 + if (!task.memory) { + log.info '[Picard MergeSamFiles] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' + } else { + avail_mem = task.memory.giga + } + if (bam_files.size() > 1) { + """ + picard \\ + -Xmx${avail_mem}g \\ + MergeSamFiles \\ + $ioptions.args \\ + ${'INPUT='+bam_files.join(' INPUT=')} \\ + OUTPUT=${prefix}.bam + echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt + """ + } else { + """ + ln -s ${bam_files[0]} ${prefix}.bam + echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt + """ + } +} diff --git a/modules/nf-core/software/preseq/lcextrap/functions.nf b/modules/nf-core/software/preseq/lcextrap/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/preseq/lcextrap/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/preseq/lcextrap/main.nf b/modules/nf-core/software/preseq/lcextrap/main.nf new file mode 100644 index 000000000..26ed3829f --- /dev/null +++ b/modules/nf-core/software/preseq/lcextrap/main.nf @@ -0,0 +1,42 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process PRESEQ_LCEXTRAP { + tag "$meta.id" + label 'process_medium' + label 'error_ignore' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/preseq:2.0.3--hf53bd2b_3" + //container "https://depot.galaxyproject.org/singularity/preseq:2.0.3--hf53bd2b_3" + + conda (params.conda ? "bioconda::preseq=2.0.3" : null) + + input: + tuple val(meta), path(bam) + val options + + output: + tuple val(meta), path("*.ccurve.txt"), emit: ccurve + tuple val(meta), path("*.log"), emit: log + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def pe = meta.single_end ? '' : '-pe' + """ + preseq \\ + lc_extrap \\ + $ioptions.args \\ + $pe \\ + -output ${prefix}.ccurve.txt \\ + $bam + cp .command.err ${prefix}.command.log + + echo \$(preseq 2>&1) | sed 's/^.*Version: //; s/Usage:.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/samtools/flagstat/functions.nf b/modules/nf-core/software/samtools/flagstat/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/samtools/flagstat/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/samtools/flagstat/main.nf b/modules/nf-core/software/samtools/flagstat/main.nf new file mode 100644 index 000000000..4c14a41ae --- /dev/null +++ b/modules/nf-core/software/samtools/flagstat/main.nf @@ -0,0 +1,29 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process SAMTOOLS_FLAGSTAT { + tag "$meta.id" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "bioconda::samtools=1.10" : null) + + input: + tuple val(meta), path(bam), path(bai) + val options + + output: + tuple val(meta), path("*.flagstat"), emit: flagstat + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + """ + samtools flagstat $bam > ${bam}.flagstat + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/samtools/idxstats/functions.nf b/modules/nf-core/software/samtools/idxstats/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/samtools/idxstats/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/samtools/idxstats/main.nf b/modules/nf-core/software/samtools/idxstats/main.nf new file mode 100644 index 000000000..9805bb141 --- /dev/null +++ b/modules/nf-core/software/samtools/idxstats/main.nf @@ -0,0 +1,29 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process SAMTOOLS_IDXSTATS { + tag "$meta.id" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "bioconda::samtools=1.10" : null) + + input: + tuple val(meta), path(bam), path(bai) + val options + + output: + tuple val(meta), path("*.idxstats"), emit: idxstats + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + """ + samtools idxstats $bam > ${bam}.idxstats + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/samtools/index/functions.nf b/modules/nf-core/software/samtools/index/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/samtools/index/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/samtools/index/main.nf b/modules/nf-core/software/samtools/index/main.nf new file mode 100644 index 000000000..456e2663d --- /dev/null +++ b/modules/nf-core/software/samtools/index/main.nf @@ -0,0 +1,29 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process SAMTOOLS_INDEX { + tag "$meta.id" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "bioconda::samtools=1.10" : null) + + input: + tuple val(meta), path(bam) + val options + + output: + tuple val(meta), path("*.bai"), emit: bai + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + """ + samtools index $bam + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/samtools/index/meta.yml b/modules/nf-core/software/samtools/index/meta.yml new file mode 100644 index 000000000..35d348027 --- /dev/null +++ b/modules/nf-core/software/samtools/index/meta.yml @@ -0,0 +1,27 @@ +name: samtools index +description: index a BAM or CRAM file +keywords: + - index +tools: + - samtools: + description: | + SAMtools is a set of utilities for interacting with and post-processing + short DNA sequence read alignments in the SAM, BAM and CRAM formats, written by Heng Li. + These files are generated as output by short read aligners like BWA. + homepage: http://www.htslib.org/ + documentation: hhttp://www.htslib.org/doc/samtools.html + doi: 10.1093/bioinformatics/btp352 +input: + - + - input: + type: file + description: Input BAM or CRAM file + pattern: "*.{bam,cram}" +output: + - + - index: + type: file + description: BAM or CRAM index file + pattern: "*.{bai}" +authors: + - "@ewels" diff --git a/modules/nf-core/software/samtools/sort/functions.nf b/modules/nf-core/software/samtools/sort/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/samtools/sort/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/samtools/sort/main.nf b/modules/nf-core/software/samtools/sort/main.nf new file mode 100644 index 000000000..9467e2aea --- /dev/null +++ b/modules/nf-core/software/samtools/sort/main.nf @@ -0,0 +1,32 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process SAMTOOLS_SORT { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "bioconda::samtools=1.10" : null) + + input: + tuple val(meta), path(bam) + val options + + output: + tuple val(meta), path("*.bam"), emit: bam + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + """ + samtools sort $ioptions.args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/samtools/sort/meta.yml b/modules/nf-core/software/samtools/sort/meta.yml new file mode 100644 index 000000000..1e042f0d7 --- /dev/null +++ b/modules/nf-core/software/samtools/sort/meta.yml @@ -0,0 +1,27 @@ +name: samtools sort +description: Sort a BAM or CRAM file +keywords: + - sort +tools: + - samtools: + description: | + SAMtools is a set of utilities for interacting with and post-processing + short DNA sequence read alignments in the SAM, BAM and CRAM formats, written by Heng Li. + These files are generated as output by short read aligners like BWA. + homepage: http://www.htslib.org/ + documentation: hhttp://www.htslib.org/doc/samtools.html + doi: 10.1093/bioinformatics/btp352 +input: + - + - input: + type: file + description: Input BAM or CRAM file + pattern: "*.{bam,cram}" +output: + - + - sorted_file: + type: file + description: Sorted BAM or CRAM file + pattern: "*.{bam,cram}" +authors: + - "@ewels" diff --git a/modules/nf-core/software/samtools/stats/functions.nf b/modules/nf-core/software/samtools/stats/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/samtools/stats/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/samtools/stats/main.nf b/modules/nf-core/software/samtools/stats/main.nf new file mode 100644 index 000000000..52d5e2d74 --- /dev/null +++ b/modules/nf-core/software/samtools/stats/main.nf @@ -0,0 +1,29 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process SAMTOOLS_STATS { + tag "$meta.id" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "bioconda::samtools=1.10" : null) + + input: + tuple val(meta), path(bam), path(bai) + val options + + output: + tuple val(meta), path("*.stats"), emit: stats + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + """ + samtools stats $bam > ${bam}.stats + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/subread/featurecounts/functions.nf b/modules/nf-core/software/subread/featurecounts/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/subread/featurecounts/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/subread/featurecounts/main.nf b/modules/nf-core/software/subread/featurecounts/main.nf new file mode 100644 index 000000000..e8a9667f3 --- /dev/null +++ b/modules/nf-core/software/subread/featurecounts/main.nf @@ -0,0 +1,41 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process SUBREAD_FEATURECOUNTS { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" + //container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" + + conda (params.conda ? "bioconda::subread=2.0.1" : null) + + input: + tuple val(meta), path(bams), path(annotation) + val options + + output: + tuple val(meta), path("*featureCounts.txt"), emit: txt + tuple val(meta), path("*featureCounts.txt.summary"), emit: summary + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def pe = meta.single_end ? '' : '-p' + """ + featureCounts \\ + $ioptions.args \\ + $pe \\ + -T $task.cpus \\ + -a $annotation \\ + -o ${prefix}.featureCounts.txt \\ + ${bams.join(' ')} + + echo \$(featureCounts -v 2>&1) | sed -e "s/featureCounts v//g" > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/trimgalore/functions.nf b/modules/nf-core/software/trimgalore/functions.nf new file mode 100644 index 000000000..dcda375c2 --- /dev/null +++ b/modules/nf-core/software/trimgalore/functions.nf @@ -0,0 +1 @@ +../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/trimgalore/main.nf b/modules/nf-core/software/trimgalore/main.nf new file mode 100644 index 000000000..219b3e659 --- /dev/null +++ b/modules/nf-core/software/trimgalore/main.nf @@ -0,0 +1,79 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process TRIMGALORE { + tag "$meta.id" + label 'process_high' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/trim-galore:0.6.5--0" + //container "https://depot.galaxyproject.org/singularity/trim-galore:0.6.5--0" + + conda (params.conda ? "bioconda::trim-galore=0.6.5" : null) + + input: + tuple val(meta), path(reads) + val options + + output: + tuple val(meta), path("*.fq.gz"), emit: reads + tuple val(meta), path("*.html"), emit: html optional true + tuple val(meta), path("*.zip"), emit: zip optional true + tuple val(meta), path("*report.txt"), emit: log + path "*.version.txt", emit: version + + script: + // Calculate number of --cores for TrimGalore based on value of task.cpus + // See: https://github.com/FelixKrueger/TrimGalore/blob/master/Changelog.md#version-060-release-on-1-mar-2019 + // See: https://github.com/nf-core/atacseq/pull/65 + def cores = 1 + if (task.cpus) { + cores = (task.cpus as int) - 4 + if (meta.single_end) cores = (task.cpus as int) - 3 + if (cores < 1) cores = 1 + if (cores > 4) cores = 4 + } + + // Clipping presets have to be evaluated in the context of SE/PE + def c_r1 = params.clip_r1 > 0 ? "--clip_r1 ${params.clip_r1}" : '' + def c_r2 = params.clip_r2 > 0 ? "--clip_r2 ${params.clip_r2}" : '' + def tpc_r1 = params.three_prime_clip_r1 > 0 ? "--three_prime_clip_r1 ${params.three_prime_clip_r1}" : '' + def tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' + + // Added soft-links to original fastqs for consistent naming in MultiQC + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + if (meta.single_end) { + """ + [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz + trim_galore \\ + $ioptions.args \\ + --cores $cores \\ + --gzip \\ + $c_r1 \\ + $tpc_r1 \\ + ${prefix}.fastq.gz + echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//' > ${software}.version.txt + """ + } else { + """ + [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz + [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz + trim_galore \\ + $ioptions.args \\ + --cores $cores \\ + --paired \\ + --gzip \\ + $c_r1 \\ + $c_r2 \\ + $tpc_r1 \\ + $tpc_r2 \\ + ${prefix}_1.fastq.gz \\ + ${prefix}_2.fastq.gz + echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//' > ${software}.version.txt + """ + } +} diff --git a/modules/nf-core/software/trimgalore/meta.yml b/modules/nf-core/software/trimgalore/meta.yml new file mode 100644 index 000000000..642fb51be --- /dev/null +++ b/modules/nf-core/software/trimgalore/meta.yml @@ -0,0 +1,40 @@ +name: Trim Galore! +description: Trim FastQ files using Trim Galore! +keywords: + - trimming + - adapters + - sequencing adapters +tools: + - fastqc: + description: | + A wrapper tool around Cutadapt and FastQC to consistently apply quality + and adapter trimming to FastQ files, with some extra functionality for + MspI-digested RRBS-type (Reduced Representation Bisufite-Seq) libraries. + homepage: https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/ + documentation: https://github.com/FelixKrueger/TrimGalore/blob/master/Docs/Trim_Galore_User_Guide.md +input: + - + - sample_id: + type: string + description: Sample identifier + - reads: + type: file + description: Input FastQ file, or pair of files +output: + - + - sample_id: + type: string + description: Sample identifier + - trimmed_fastq: + type: file + description: Trimmed FastQ files + pattern: "*fq.gz" + - + - report: + type: file + description: Trim Galore! trimming report + pattern: "*trimming_report.txt" + +authors: + - "@ewels" + - "@FelixKrueger" diff --git a/modules/nf-core/software/ucsc/bedgraphtobigwig/functions.nf b/modules/nf-core/software/ucsc/bedgraphtobigwig/functions.nf new file mode 100644 index 000000000..5e1a8e039 --- /dev/null +++ b/modules/nf-core/software/ucsc/bedgraphtobigwig/functions.nf @@ -0,0 +1 @@ +../../lib/functions.nf \ No newline at end of file diff --git a/modules/nf-core/software/ucsc/bedgraphtobigwig/main.nf b/modules/nf-core/software/ucsc/bedgraphtobigwig/main.nf new file mode 100644 index 000000000..4da63fe1f --- /dev/null +++ b/modules/nf-core/software/ucsc/bedgraphtobigwig/main.nf @@ -0,0 +1,35 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +def VERSION = '377' + +process UCSC_BEDRAPHTOBIGWIG { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/ucsc-bedgraphtobigwig:377--h446ed27_1" + //container "https://depot.galaxyproject.org/singularity/ucsc-bedgraphtobigwig:377--h446ed27_1" + + conda (params.conda ? "bioconda::ucsc-bedgraphtobigwig=377" : null) + + input: + tuple val(meta), path(bedgraph) + path sizes + val options + + output: + tuple val(meta), path("*.bigWig"), emit: bigwig + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + """ + bedGraphToBigWig $bedgraph $sizes ${prefix}.bigWig + echo $VERSION > ${software}.version.txt + """ +} From d5efb1c2686c7ac0e2c73bee46c45d99527807ea Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 5 Aug 2020 19:38:44 +0100 Subject: [PATCH 146/538] Switch to nf-core/modules --- main.nf | 26 ++++---- .../nf-core/software/bwa/index/functions.nf | 60 ++++++++++++++++++- modules/nf-core/software/bwa/mem/functions.nf | 60 ++++++++++++++++++- .../deeptools/computematrix/functions.nf | 60 ++++++++++++++++++- .../deeptools/plotfingerprint/functions.nf | 60 ++++++++++++++++++- .../deeptools/plotheatmap/functions.nf | 60 ++++++++++++++++++- .../deeptools/plotprofile/functions.nf | 60 ++++++++++++++++++- modules/nf-core/software/fastqc/functions.nf | 60 ++++++++++++++++++- .../software/homer/annotatepeaks/functions.nf | 60 ++++++++++++++++++- .../software/macs2/callpeak/functions.nf | 60 ++++++++++++++++++- .../phantompeakqualtools/functions.nf | 60 ++++++++++++++++++- .../collectmultiplemetrics/functions.nf | 60 ++++++++++++++++++- .../picard/markduplicates/functions.nf | 60 ++++++++++++++++++- .../picard/mergesamfiles/functions.nf | 60 ++++++++++++++++++- .../software/preseq/lcextrap/functions.nf | 60 ++++++++++++++++++- .../software/samtools/flagstat/functions.nf | 60 ++++++++++++++++++- .../software/samtools/idxstats/functions.nf | 60 ++++++++++++++++++- .../software/samtools/index/functions.nf | 60 ++++++++++++++++++- .../software/samtools/sort/functions.nf | 60 ++++++++++++++++++- .../software/samtools/stats/functions.nf | 60 ++++++++++++++++++- .../subread/featurecounts/functions.nf | 60 ++++++++++++++++++- .../nf-core/software/trimgalore/functions.nf | 60 ++++++++++++++++++- .../ucsc/bedgraphtobigwig/functions.nf | 60 ++++++++++++++++++- .../nf-core/subworkflow/bam_sort_samtools.nf | 4 +- .../nf-core/subworkflow/bam_stats_samtools.nf | 6 +- .../nf-core/subworkflow/fastqc_trimgalore.nf | 4 +- modules/nf-core/subworkflow/map_bwa_mem.nf | 2 +- .../subworkflow/mark_duplicates_picard.nf | 4 +- 28 files changed, 1321 insertions(+), 45 deletions(-) diff --git a/main.nf b/main.nf index 8970be09f..2703f777a 100755 --- a/main.nf +++ b/main.nf @@ -155,20 +155,20 @@ include { BAM_CLEAN } from './modules/local/subworkflo /* -- IMPORT NF-CORE MODULES/SUBWORKFLOWS -- */ //////////////////////////////////////////////////// -include { BWA_INDEX } from './modules/nf-core/software/bwa/index' -include { PICARD_MERGESAMFILES } from './modules/nf-core/software/picard/mergesamfiles' -include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/software/picard/collectmultiplemetrics' -include { PRESEQ_LCEXTRAP } from './modules/nf-core/software/preseq/lcextrap' -include { UCSC_BEDRAPHTOBIGWIG } from './modules/nf-core/software/ucsc/bedgraphtobigwig' -include { DEEPTOOLS_COMPUTEMATRIX } from './modules/nf-core/software/deeptools/computematrix' -include { DEEPTOOLS_PLOTPROFILE } from './modules/nf-core/software/deeptools/plotprofile' -include { DEEPTOOLS_PLOTHEATMAP } from './modules/nf-core/software/deeptools/plotheatmap' -include { DEEPTOOLS_PLOTFINGERPRINT } from './modules/nf-core/software/deeptools/plotfingerprint' -include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/software/phantompeakqualtools' -include { MACS2_CALLPEAK } from './modules/nf-core/software/macs2/callpeak' +include { BWA_INDEX } from './modules/nf-core/software/bwa/index/main' +include { PICARD_MERGESAMFILES } from './modules/nf-core/software/picard/mergesamfiles/main' +include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/software/picard/collectmultiplemetrics/main' +include { PRESEQ_LCEXTRAP } from './modules/nf-core/software/preseq/lcextrap/main' +include { UCSC_BEDRAPHTOBIGWIG } from './modules/nf-core/software/ucsc/bedgraphtobigwig/main' +include { DEEPTOOLS_COMPUTEMATRIX } from './modules/nf-core/software/deeptools/computematrix/main' +include { DEEPTOOLS_PLOTPROFILE } from './modules/nf-core/software/deeptools/plotprofile/main' +include { DEEPTOOLS_PLOTHEATMAP } from './modules/nf-core/software/deeptools/plotheatmap/main' +include { DEEPTOOLS_PLOTFINGERPRINT } from './modules/nf-core/software/deeptools/plotfingerprint/main' +include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/software/phantompeakqualtools/main' +include { MACS2_CALLPEAK } from './modules/nf-core/software/macs2/callpeak/main' include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 - HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from './modules/nf-core/software/homer/annotatepeaks' -include { SUBREAD_FEATURECOUNTS } from './modules/nf-core/software/subread/featurecounts' + HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from './modules/nf-core/software/homer/annotatepeaks/main' +include { SUBREAD_FEATURECOUNTS } from './modules/nf-core/software/subread/featurecounts/main' include { FASTQC_TRIMGALORE } from './modules/nf-core/subworkflow/fastqc_trimgalore' include { MAP_BWA_MEM } from './modules/nf-core/subworkflow/map_bwa_mem' diff --git a/modules/nf-core/software/bwa/index/functions.nf b/modules/nf-core/software/bwa/index/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/bwa/index/functions.nf +++ b/modules/nf-core/software/bwa/index/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/bwa/mem/functions.nf b/modules/nf-core/software/bwa/mem/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/bwa/mem/functions.nf +++ b/modules/nf-core/software/bwa/mem/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/deeptools/computematrix/functions.nf b/modules/nf-core/software/deeptools/computematrix/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/deeptools/computematrix/functions.nf +++ b/modules/nf-core/software/deeptools/computematrix/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/deeptools/plotfingerprint/functions.nf b/modules/nf-core/software/deeptools/plotfingerprint/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/deeptools/plotfingerprint/functions.nf +++ b/modules/nf-core/software/deeptools/plotfingerprint/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/deeptools/plotheatmap/functions.nf b/modules/nf-core/software/deeptools/plotheatmap/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/deeptools/plotheatmap/functions.nf +++ b/modules/nf-core/software/deeptools/plotheatmap/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/deeptools/plotprofile/functions.nf b/modules/nf-core/software/deeptools/plotprofile/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/deeptools/plotprofile/functions.nf +++ b/modules/nf-core/software/deeptools/plotprofile/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/fastqc/functions.nf b/modules/nf-core/software/fastqc/functions.nf index dcda375c2..75553cdf5 100644 --- a/modules/nf-core/software/fastqc/functions.nf +++ b/modules/nf-core/software/fastqc/functions.nf @@ -1 +1,59 @@ -../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/homer/annotatepeaks/functions.nf b/modules/nf-core/software/homer/annotatepeaks/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/homer/annotatepeaks/functions.nf +++ b/modules/nf-core/software/homer/annotatepeaks/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/macs2/callpeak/functions.nf b/modules/nf-core/software/macs2/callpeak/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/macs2/callpeak/functions.nf +++ b/modules/nf-core/software/macs2/callpeak/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/phantompeakqualtools/functions.nf b/modules/nf-core/software/phantompeakqualtools/functions.nf index dcda375c2..75553cdf5 100644 --- a/modules/nf-core/software/phantompeakqualtools/functions.nf +++ b/modules/nf-core/software/phantompeakqualtools/functions.nf @@ -1 +1,59 @@ -../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/picard/collectmultiplemetrics/functions.nf b/modules/nf-core/software/picard/collectmultiplemetrics/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/picard/collectmultiplemetrics/functions.nf +++ b/modules/nf-core/software/picard/collectmultiplemetrics/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/picard/markduplicates/functions.nf b/modules/nf-core/software/picard/markduplicates/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/picard/markduplicates/functions.nf +++ b/modules/nf-core/software/picard/markduplicates/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/picard/mergesamfiles/functions.nf b/modules/nf-core/software/picard/mergesamfiles/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/picard/mergesamfiles/functions.nf +++ b/modules/nf-core/software/picard/mergesamfiles/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/preseq/lcextrap/functions.nf b/modules/nf-core/software/preseq/lcextrap/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/preseq/lcextrap/functions.nf +++ b/modules/nf-core/software/preseq/lcextrap/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/samtools/flagstat/functions.nf b/modules/nf-core/software/samtools/flagstat/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/samtools/flagstat/functions.nf +++ b/modules/nf-core/software/samtools/flagstat/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/samtools/idxstats/functions.nf b/modules/nf-core/software/samtools/idxstats/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/samtools/idxstats/functions.nf +++ b/modules/nf-core/software/samtools/idxstats/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/samtools/index/functions.nf b/modules/nf-core/software/samtools/index/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/samtools/index/functions.nf +++ b/modules/nf-core/software/samtools/index/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/samtools/sort/functions.nf b/modules/nf-core/software/samtools/sort/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/samtools/sort/functions.nf +++ b/modules/nf-core/software/samtools/sort/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/samtools/stats/functions.nf b/modules/nf-core/software/samtools/stats/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/samtools/stats/functions.nf +++ b/modules/nf-core/software/samtools/stats/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/subread/featurecounts/functions.nf b/modules/nf-core/software/subread/featurecounts/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/subread/featurecounts/functions.nf +++ b/modules/nf-core/software/subread/featurecounts/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/trimgalore/functions.nf b/modules/nf-core/software/trimgalore/functions.nf index dcda375c2..75553cdf5 100644 --- a/modules/nf-core/software/trimgalore/functions.nf +++ b/modules/nf-core/software/trimgalore/functions.nf @@ -1 +1,59 @@ -../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/ucsc/bedgraphtobigwig/functions.nf b/modules/nf-core/software/ucsc/bedgraphtobigwig/functions.nf index 5e1a8e039..75553cdf5 100644 --- a/modules/nf-core/software/ucsc/bedgraphtobigwig/functions.nf +++ b/modules/nf-core/software/ucsc/bedgraphtobigwig/functions.nf @@ -1 +1,59 @@ -../../lib/functions.nf \ No newline at end of file +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/subworkflow/bam_sort_samtools.nf b/modules/nf-core/subworkflow/bam_sort_samtools.nf index 7c42591cc..d55b9aad1 100644 --- a/modules/nf-core/subworkflow/bam_sort_samtools.nf +++ b/modules/nf-core/subworkflow/bam_sort_samtools.nf @@ -2,8 +2,8 @@ * Sort, index BAM file and run samtools stats, flagstat and idxstats */ -include { SAMTOOLS_SORT } from '../software/samtools/sort' -include { SAMTOOLS_INDEX } from '../software/samtools/index' +include { SAMTOOLS_SORT } from '../software/samtools/sort/main' +include { SAMTOOLS_INDEX } from '../software/samtools/index/main' include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' workflow BAM_SORT_SAMTOOLS { diff --git a/modules/nf-core/subworkflow/bam_stats_samtools.nf b/modules/nf-core/subworkflow/bam_stats_samtools.nf index c4e55377b..669ae6a54 100644 --- a/modules/nf-core/subworkflow/bam_stats_samtools.nf +++ b/modules/nf-core/subworkflow/bam_stats_samtools.nf @@ -2,9 +2,9 @@ * Run SAMtools stats, flagstat and idxstats */ -include { SAMTOOLS_STATS } from '../software/samtools/stats' -include { SAMTOOLS_IDXSTATS } from '../software/samtools/idxstats' -include { SAMTOOLS_FLAGSTAT } from '../software/samtools/flagstat' +include { SAMTOOLS_STATS } from '../software/samtools/stats/main' +include { SAMTOOLS_IDXSTATS } from '../software/samtools/idxstats/main' +include { SAMTOOLS_FLAGSTAT } from '../software/samtools/flagstat/main' workflow BAM_STATS_SAMTOOLS { take: diff --git a/modules/nf-core/subworkflow/fastqc_trimgalore.nf b/modules/nf-core/subworkflow/fastqc_trimgalore.nf index 8cb75d659..365d313dc 100644 --- a/modules/nf-core/subworkflow/fastqc_trimgalore.nf +++ b/modules/nf-core/subworkflow/fastqc_trimgalore.nf @@ -2,8 +2,8 @@ * Read QC and trimming */ -include { FASTQC } from '../software/fastqc' -include { TRIMGALORE } from '../software/trimgalore' +include { FASTQC } from '../software/fastqc/main' +include { TRIMGALORE } from '../software/trimgalore/main' workflow FASTQC_TRIMGALORE { take: diff --git a/modules/nf-core/subworkflow/map_bwa_mem.nf b/modules/nf-core/subworkflow/map_bwa_mem.nf index 92b53260f..f46077e4b 100644 --- a/modules/nf-core/subworkflow/map_bwa_mem.nf +++ b/modules/nf-core/subworkflow/map_bwa_mem.nf @@ -2,7 +2,7 @@ * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats */ -include { BWA_MEM } from '../software/bwa/mem' +include { BWA_MEM } from '../software/bwa/mem/main' include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' workflow MAP_BWA_MEM { diff --git a/modules/nf-core/subworkflow/mark_duplicates_picard.nf b/modules/nf-core/subworkflow/mark_duplicates_picard.nf index 10ade11e9..f147831f5 100644 --- a/modules/nf-core/subworkflow/mark_duplicates_picard.nf +++ b/modules/nf-core/subworkflow/mark_duplicates_picard.nf @@ -2,8 +2,8 @@ * Picard MarkDuplicates, sort, index BAM file and run samtools stats, flagstat and idxstats */ -include { PICARD_MARKDUPLICATES } from '../software/picard/markduplicates' -include { SAMTOOLS_INDEX } from '../software/samtools/index' +include { PICARD_MARKDUPLICATES } from '../software/picard/markduplicates/main' +include { SAMTOOLS_INDEX } from '../software/samtools/index/main' include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' workflow MARK_DUPLICATES_PICARD { From 297e48cb61141ce78af2c6ff676c0c24caa66bc2 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 17 Aug 2020 09:03:22 +0100 Subject: [PATCH 147/538] Remove input in docs --- docs/usage.md | 8 -------- 1 file changed, 8 deletions(-) diff --git a/docs/usage.md b/docs/usage.md index d9ed25562..7005fb215 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -152,14 +152,6 @@ If `-profile` is not specified, the pipeline will run locally and expect all sof * A profile with a complete configuration for automated testing * Includes links to test data so needs no other parameters -### `--input` - -You will need to create a design file with information about the samples in your experiment before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 6 columns, and a header row as shown in the examples below. - -```bash ---input '[path to design file]' -``` - ### `-resume` Specify this when restarting a pipeline. Nextflow will used cached results from any pipeline steps where the inputs are the same, continuing from where it got to previously. From 7b9403e0f99d68c55c18979a97ba7fd678c34da1 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 17 Aug 2020 09:12:22 +0100 Subject: [PATCH 148/538] Update schema --- nextflow_schema.json | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index c24063e1c..177bebb3a 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -17,7 +17,7 @@ "input": { "type": "string", "description": "Path to comma-separated file containing information about the samples in the experiment.", - "help_text": "You will need to create a design file with information about the samples in your experiment before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 4 columns, and a header row. See [usage docs](https://nf-co.re/chipseq/docs/usage#--input).", + "help_text": "You will need to create a design file with information about the samples in your experiment before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 6 columns, and a header row. See [usage docs](https://nf-co.re/chipseq/docs/usage#introduction).", "fa_icon": "fas fa-file-csv" }, "fragment_size": { From ddc992d04b740781523714d4180fa5eab7a022ab Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 17 Aug 2020 13:53:12 +0100 Subject: [PATCH 149/538] Fix lint warnings --- .github/workflows/awsfulltest.yml | 6 +----- docs/README.md | 2 -- lib/Completion.groovy | 1 - 3 files changed, 1 insertion(+), 8 deletions(-) diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index 75a51e5fe..fd2b0e061 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -20,10 +20,6 @@ jobs: - name: Install awscli run: conda install -c conda-forge awscli - name: Start AWS batch job - # TODO nf-core: You can customise AWS full pipeline tests as required - # Add full size test data (but still relatively small datasets for few samples) - # on the `test_full.config` test runs with only one set of parameters - # Then specify `-profile test_full` instead of `-profile test` on the AWS batch command env: AWS_ACCESS_KEY_ID: ${{ secrets.AWS_ACCESS_KEY_ID }} AWS_SECRET_ACCESS_KEY: ${{ secrets.AWS_SECRET_ACCESS_KEY }} @@ -37,4 +33,4 @@ jobs: --job-name nf-core-chipseq \ --job-queue $AWS_JOB_QUEUE \ --job-definition $AWS_JOB_DEFINITION \ - --container-overrides '{"command": ["nf-core/chipseq", "-r '"${GITHUB_SHA}"' -profile test --outdir s3://'"${AWS_S3_BUCKET}"'/chipseq/results-'"${GITHUB_SHA}"' -w s3://'"${AWS_S3_BUCKET}"'/chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}' + --container-overrides '{"command": ["nf-core/chipseq", "-r '"${GITHUB_SHA}"' -profile test_full --outdir s3://'"${AWS_S3_BUCKET}"'/chipseq/results-'"${GITHUB_SHA}"' -w s3://'"${AWS_S3_BUCKET}"'/chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}' diff --git a/docs/README.md b/docs/README.md index 2a650655f..ac8a8b69c 100644 --- a/docs/README.md +++ b/docs/README.md @@ -2,8 +2,6 @@ The nf-core/chipseq documentation is split into the following pages: - - * [Usage](usage.md) * An overview of how the pipeline works, how to run it and a description of all of the different command-line flags. * [Output](output.md) diff --git a/lib/Completion.groovy b/lib/Completion.groovy index 4363275dd..1dceae82c 100755 --- a/lib/Completion.groovy +++ b/lib/Completion.groovy @@ -34,7 +34,6 @@ class Completion { email_fields['summary']['Nextflow Build'] = workflow.nextflow.build email_fields['summary']['Nextflow Compile Timestamp'] = workflow.nextflow.timestamp - // TODO nf-core: If not using MultiQC, strip out this code (including params.max_multiqc_email_size) // On success try attach the multiqc report def mqc_report = null try { From 1362e4c5109965e10531fa8a1dd2c9e87ee48ee2 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Mon, 17 Aug 2020 18:16:43 +0100 Subject: [PATCH 150/538] Fix awstest bug --- .github/workflows/awstest.yml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/.github/workflows/awstest.yml b/.github/workflows/awstest.yml index c951c7346..ff7ae535c 100644 --- a/.github/workflows/awstest.yml +++ b/.github/workflows/awstest.yml @@ -34,4 +34,4 @@ jobs: --job-name nf-core-chipseq \ --job-queue $AWS_JOB_QUEUE \ --job-definition $AWS_JOB_DEFINITION \ - --container-overrides '{"command": ["nf-core/chipseq", "-r '"${GITHUB_SHA}"' -profile test --outdir s3://'"${AWS_S3_BUCKET}"'/chipseq/results-'"${GITHUB_SHA}"' -w s3://'"${AWS_S3_BUCKET}"'/chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}'chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}' + --container-overrides '{"command": ["nf-core/chipseq", "-r '"${GITHUB_SHA}"' -profile test --outdir s3://'"${AWS_S3_BUCKET}"'/chipseq/results-'"${GITHUB_SHA}"' -w s3://'"${AWS_S3_BUCKET}"'/chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}' From 37fb93ad4a784e1505811383b8e34028dbd80454 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 18 Aug 2020 11:55:59 +0100 Subject: [PATCH 151/538] Update schema --- nextflow_schema.json | 16 ++++++---------- 1 file changed, 6 insertions(+), 10 deletions(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index 177bebb3a..aab35a08f 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -18,12 +18,14 @@ "type": "string", "description": "Path to comma-separated file containing information about the samples in the experiment.", "help_text": "You will need to create a design file with information about the samples in your experiment before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 6 columns, and a header row. See [usage docs](https://nf-co.re/chipseq/docs/usage#introduction).", - "fa_icon": "fas fa-file-csv" + "fa_icon": "fas fa-file-csv", + "default": "./design.csv" }, "fragment_size": { "type": "integer", "description": "Estimated fragment size used to extend single-end reads.", - "fa_icon": "fas fa-chart-area" + "fa_icon": "fas fa-chart-area", + "default": "200" }, "seq_center": { "type": "string", @@ -234,7 +236,7 @@ "type": "integer", "default": 1, "description": "Number of biological replicates required from a given condition for a peak to contribute to a consensus peak.", - "help_text": "If you are confident you have good reproducibility amongst your replicates then you can increase the value of this parameter to create a \"reproducible\" set of consensus peaks. For example, a value of 2 will mean peaks that have been called in at least 2 replicates will contribute to the consensus set of peaks, and as such peaks that are unique to a given replicate will be discarded.", + "help_text": "If you are confident you have good reproducibility amongst your replicates then you can increase the value of this parameter to create a 'reproducible' set of consensus peaks. For example, a value of 2 will mean peaks that have been called in at least 2 replicates will contribute to the consensus set of peaks, and as such peaks that are unique to a given replicate will be discarded.", "fa_icon": "fas fa-sort-numeric-down" }, "save_macs_pileup": { @@ -439,7 +441,7 @@ "link", "copy", "copyNoFollow", - "mov" + "move" ], "hidden": true }, @@ -500,12 +502,6 @@ "type": "boolean", "description": "Run this workflow with Conda.", "hidden": true - }, - "modules": { - "type": "string", - "default": "", - "description": "Parameter used to supply options to nf-core/modules files. Won't need to be provided on the command-line.", - "hidden": true } } } From 43d5882911b40deb04073a146416ca51f61a2597 Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Tue, 27 Oct 2020 09:25:26 +0000 Subject: [PATCH 152/538] Template update for nf-core/tools version 1.11 --- .github/CONTRIBUTING.md | 2 +- .github/ISSUE_TEMPLATE/bug_report.md | 2 +- .github/workflows/awsfulltest.yml | 4 +++- .github/workflows/awstest.yml | 9 ++++----- Dockerfile | 2 +- README.md | 10 +++++----- docs/README.md | 2 -- docs/output.md | 8 +++++++- docs/usage.md | 13 ++++++++++--- nextflow.config | 3 +++ nextflow_schema.json | 4 ++-- 11 files changed, 37 insertions(+), 22 deletions(-) diff --git a/.github/CONTRIBUTING.md b/.github/CONTRIBUTING.md index cb1a4e6d7..b8928af63 100644 --- a/.github/CONTRIBUTING.md +++ b/.github/CONTRIBUTING.md @@ -54,4 +54,4 @@ These tests are run both with the latest available version of `Nextflow` and als ## Getting help -For further information/help, please consult the [nf-core/chipseq documentation](https://nf-co.re/chipseq/docs) and don't hesitate to get in touch on the nf-core Slack [#chipseq](https://nfcore.slack.com/channels/chipseq) channel ([join our Slack here](https://nf-co.re/join/slack)). +For further information/help, please consult the [nf-core/chipseq documentation](https://nf-co.re/chipseq/usage) and don't hesitate to get in touch on the nf-core Slack [#chipseq](https://nfcore.slack.com/channels/chipseq) channel ([join our Slack here](https://nf-co.re/join/slack)). diff --git a/.github/ISSUE_TEMPLATE/bug_report.md b/.github/ISSUE_TEMPLATE/bug_report.md index 7781a9117..dfb5c2cbf 100644 --- a/.github/ISSUE_TEMPLATE/bug_report.md +++ b/.github/ISSUE_TEMPLATE/bug_report.md @@ -36,7 +36,7 @@ Steps to reproduce the behaviour: ## Container engine -- Engine: +- Engine: - version: - Image tag: diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index 75a51e5fe..48a2b35a9 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -1,10 +1,12 @@ name: nf-core AWS full size tests -# This workflow is triggered on push to the master branch. +# This workflow is triggered on published releases. +# It can be additionally triggered manually with GitHub actions workflow dispatch. # It runs the -profile 'test_full' on AWS batch on: release: types: [published] + workflow_dispatch: jobs: run-awstest: diff --git a/.github/workflows/awstest.yml b/.github/workflows/awstest.yml index 5da17324e..eb41dffe8 100644 --- a/.github/workflows/awstest.yml +++ b/.github/workflows/awstest.yml @@ -1,11 +1,10 @@ name: nf-core AWS test # This workflow is triggered on push to the master branch. -# It runs the -profile 'test' on AWS batch +# It can be additionally triggered manually with GitHub actions workflow dispatch. +# It runs the -profile 'test' on AWS batch. on: - push: - branches: - - master + workflow_dispatch: jobs: run-awstest: @@ -37,4 +36,4 @@ jobs: --job-name nf-core-chipseq \ --job-queue $AWS_JOB_QUEUE \ --job-definition $AWS_JOB_DEFINITION \ - --container-overrides '{"command": ["nf-core/chipseq", "-r '"${GITHUB_SHA}"' -profile test --outdir s3://'"${AWS_S3_BUCKET}"'/chipseq/results-'"${GITHUB_SHA}"' -w s3://'"${AWS_S3_BUCKET}"'/chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}'chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}' + --container-overrides '{"command": ["nf-core/chipseq", "-r '"${GITHUB_SHA}"' -profile test --outdir s3://'"${AWS_S3_BUCKET}"'/chipseq/results-'"${GITHUB_SHA}"' -w s3://'"${AWS_S3_BUCKET}"'/chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}' diff --git a/Dockerfile b/Dockerfile index b739ba3eb..ef55eb905 100644 --- a/Dockerfile +++ b/Dockerfile @@ -1,4 +1,4 @@ -FROM nfcore/base:1.10.2 +FROM nfcore/base:1.11 LABEL authors="Philip Ewels" \ description="Docker image containing all software requirements for the nf-core/chipseq pipeline" diff --git a/README.md b/README.md index 256076543..51c133cd3 100644 --- a/README.md +++ b/README.md @@ -18,12 +18,12 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool 1. Install [`nextflow`](https://nf-co.re/usage/installation) -2. Install either [`Docker`](https://docs.docker.com/engine/installation/) or [`Singularity`](https://www.sylabs.io/guides/3.0/user-guide/) for full pipeline reproducibility _(please only use [`Conda`](https://conda.io/miniconda.html) as a last resort; see [docs](https://nf-co.re/usage/configuration#basic-configuration-profiles))_ +2. Install any of [`Docker`](https://docs.docker.com/engine/installation/), [`Singularity`](https://www.sylabs.io/guides/3.0/user-guide/) or [`Podman`](https://podman.io/) for full pipeline reproducibility _(please only use [`Conda`](https://conda.io/miniconda.html) as a last resort; see [docs](https://nf-co.re/usage/configuration#basic-configuration-profiles))_ 3. Download the pipeline and test it on a minimal dataset with a single command: ```bash - nextflow run nf-core/chipseq -profile test, + nextflow run nf-core/chipseq -profile test, ``` > Please check [nf-core/configs](https://github.com/nf-core/configs#documentation) to see if a custom config file to run nf-core pipelines already exists for your Institute. If so, you can simply use `-profile ` in your command. This will enable either `docker` or `singularity` and set the appropriate execution settings for your local compute environment. @@ -33,14 +33,14 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool ```bash - nextflow run nf-core/chipseq -profile --input '*_R{1,2}.fastq.gz' --genome GRCh37 + nextflow run nf-core/chipseq -profile --input '*_R{1,2}.fastq.gz' --genome GRCh37 ``` -See [usage docs](docs/usage.md) for all of the available options when running the pipeline. +See [usage docs](https://nf-co.re/chipseq/usage) for all of the available options when running the pipeline. ## Documentation -The nf-core/chipseq pipeline comes with documentation about the pipeline which you can read at [https://nf-core/chipseq/docs](https://nf-core/chipseq/docs) or find in the [`docs/` directory](docs). +The nf-core/chipseq pipeline comes with documentation about the pipeline: [usage](https://nf-co.re/chipseq/usage) and [output](https://nf-co.re/chipseq/output). diff --git a/docs/README.md b/docs/README.md index 84fa58441..68b828949 100644 --- a/docs/README.md +++ b/docs/README.md @@ -2,8 +2,6 @@ The nf-core/chipseq documentation is split into the following pages: - - * [Usage](usage.md) * An overview of how the pipeline works, how to run it and a description of all of the different command-line flags. * [Output](output.md) diff --git a/docs/output.md b/docs/output.md index 0bed8064d..c2c866c10 100644 --- a/docs/output.md +++ b/docs/output.md @@ -1,5 +1,11 @@ # nf-core/chipseq: Output +## :warning: Please read this documentation on the nf-core website: [https://nf-co.re/chipseq/output](https://nf-co.re/chipseq/output) + +> _Documentation of pipeline parameters is generated automatically from the pipeline schema and can no longer be found in markdown files._ + +## Introduction + This document describes the output produced by the pipeline. Most of the plots are taken from the MultiQC report, which summarises results at the end of the pipeline. The directories listed below will be created in the results directory after the pipeline has finished. All paths are relative to the top-level results directory. @@ -40,7 +46,7 @@ For more information about how to use MultiQC reports, see [https://multiqc.info **Output files:** -* `multiqc/` +* `multiqc/` * `multiqc_report.html`: a standalone HTML file that can be viewed in your web browser. * `multiqc_data/`: directory containing parsed statistics from the different tools used in the pipeline. * `multiqc_plots/`: directory containing static images from the report in various formats. diff --git a/docs/usage.md b/docs/usage.md index ceaa7dd4d..5bb81b07a 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -1,5 +1,9 @@ # nf-core/chipseq: Usage +## :warning: Please read this documentation on the nf-core website: [https://nf-co.re/chipseq/usage](https://nf-co.re/chipseq/usage) + +> _Documentation of pipeline parameters is generated automatically from the pipeline schema and can no longer be found in markdown files._ + ## Introduction @@ -47,7 +51,7 @@ This version number will be logged in reports when you run the pipeline, so that Use this parameter to choose a configuration profile. Profiles can give configuration presets for different compute environments. -Several generic profiles are bundled with the pipeline which instruct the pipeline to use software packaged using different methods (Docker, Singularity, Conda) - see below. +Several generic profiles are bundled with the pipeline which instruct the pipeline to use software packaged using different methods (Docker, Singularity, Podman, Conda) - see below. > We highly recommend the use of Docker or Singularity containers for full pipeline reproducibility, however when this is not possible, Conda is also supported. @@ -64,8 +68,11 @@ If `-profile` is not specified, the pipeline will run locally and expect all sof * `singularity` * A generic configuration profile to be used with [Singularity](https://sylabs.io/docs/) * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) +* `podman` + * A generic configuration profile to be used with [Podman](https://podman.io/) + * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) * `conda` - * Please only use Conda as a last resort i.e. when it's not possible to run the pipeline with Docker or Singularity. + * Please only use Conda as a last resort i.e. when it's not possible to run the pipeline with Docker, Singularity or Podman. * A generic configuration profile to be used with [Conda](https://conda.io/docs/) * Pulls most software from [Bioconda](https://bioconda.github.io/) * `test` @@ -98,7 +105,7 @@ process { See the main [Nextflow documentation](https://www.nextflow.io/docs/latest/config.html) for more information. -If you are likely to be running `nf-core` pipelines regularly it may be a good idea to request that your custom config file is uploaded to the `nf-core/configs` git repository. Before you do this please can you test that the config file works with your pipeline of choice using the `-c` parameter (see definition below). You can then create a pull request to the `nf-core/configs` repository with the addition of your config file, associated documentation file (see examples in [`nf-core/configs/docs`](https://github.com/nf-core/configs/tree/master/docs)), and amending [`nfcore_custom.config`](https://github.com/nf-core/configs/blob/master/nfcore_custom.config) to include your custom profile. +If you are likely to be running `nf-core` pipelines regularly it may be a good idea to request that your custom config file is uploaded to the `nf-core/configs` git repository. Before you do this please can you test that the config file works with your pipeline of choice using the `-c` parameter (see definition above). You can then create a pull request to the `nf-core/configs` repository with the addition of your config file, associated documentation file (see examples in [`nf-core/configs/docs`](https://github.com/nf-core/configs/tree/master/docs)), and amending [`nfcore_custom.config`](https://github.com/nf-core/configs/blob/master/nfcore_custom.config) to include your custom profile. If you have any questions or issues please send us a message on [Slack](https://nf-co.re/join/slack) on the [`#configs` channel](https://nfcore.slack.com/channels/configs). diff --git a/nextflow.config b/nextflow.config index a547df3fc..71ebe2f8d 100644 --- a/nextflow.config +++ b/nextflow.config @@ -71,6 +71,9 @@ profiles { singularity.enabled = true singularity.autoMounts = true } + podman { + podman.enabled = true + } test { includeConfig 'conf/test.config' } } diff --git a/nextflow_schema.json b/nextflow_schema.json index 37e0fdf2e..8641ae9a6 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -1,5 +1,5 @@ { - "$schema": "https://json-schema.org/draft-07/schema", + "$schema": "http://json-schema.org/draft-07/schema", "$id": "https://raw.githubusercontent.com/nf-core/chipseq/master/nextflow_schema.json", "title": "nf-core/chipseq pipeline parameters", "description": "ChIP-seq peak-calling and differential analysis pipeline.", @@ -101,7 +101,7 @@ "link", "copy", "copyNoFollow", - "mov" + "move" ] }, "name": { From 55157145e643bbc3b5169d4e775a3aaca79818ae Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 27 Oct 2020 12:39:17 +0000 Subject: [PATCH 153/538] Get tests passing after template update --- CHANGELOG.md | 2 +- bin/check_samplesheet.py | 2 +- modules/local/process/functions.nf | 2 +- 3 files changed, 3 insertions(+), 3 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 2a1170ab0..3eedea2fb 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -9,7 +9,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 * Move template boilerplate code to Groovy `lib/` * Implement pipeline in DSL2 -* Update template to tools `1.10.2` +* Update pipeline template to nf-core/tools `1.11` ### `Fixed` diff --git a/bin/check_samplesheet.py b/bin/check_samplesheet.py index e81d5cdc9..79b36ba52 100755 --- a/bin/check_samplesheet.py +++ b/bin/check_samplesheet.py @@ -118,7 +118,7 @@ def check_samplesheet(file_in, file_out): if sample_info in sample_run_dict[sample][replicate]: print_error("Samplesheet contains duplicate rows!", 'Line', line) else: - sample_run_dict[sample].append(sample_info) + sample_run_dict[sample][replicate].append(sample_info) ## Check if antibody and control columns have been specified at least once if len(antibody_dict) == 0: diff --git a/modules/local/process/functions.nf b/modules/local/process/functions.nf index 75553cdf5..6f72fdc10 100644 --- a/modules/local/process/functions.nf +++ b/modules/local/process/functions.nf @@ -20,7 +20,7 @@ def initOptions(Map args) { options.args2 = args.args2 ?: '' options.publish_by_id = args.publish_by_id ?: false options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files ?: null + options.publish_files = (args.publish_files instanceof Map)? args.publish_files : null options.suffix = args.suffix ?: '' return options } From 789c6b30d26b7919d9b72459d1c4ffdfca0756f9 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 27 Oct 2020 12:53:03 +0000 Subject: [PATCH 154/538] Use default tabs for markdownlint --- .github/markdownlint.yml | 2 -- 1 file changed, 2 deletions(-) diff --git a/.github/markdownlint.yml b/.github/markdownlint.yml index cc8e0d331..49faba254 100644 --- a/.github/markdownlint.yml +++ b/.github/markdownlint.yml @@ -5,5 +5,3 @@ no-duplicate-header: siblings_only: true MD033: allowed_elements: [details, summary, p, img] -MD007: - indent: 4 From 098b1036ad80bd5fc0e6644e59794add2ff4bd56 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 27 Oct 2020 13:00:29 +0000 Subject: [PATCH 155/538] Fix markdownlint --- CHANGELOG.md | 16 ++++++++-------- 1 file changed, 8 insertions(+), 8 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 3eedea2fb..f136853d2 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -43,14 +43,14 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 * Replace `set` with `tuple` and `file()` with `path()` in all processes * Capitalise process names * Parameters: - * `--bwa_min_score` to set minimum alignment score for BWA MEM - * `--macs_fdr` to provide FDR threshold for MACS2 peak calling - * `--macs_pvalue` to provide p-value threshold for MACS2 peak calling - * `--skip_peak_qc` to skip MACS2 peak QC plot generation - * `--skip_peak_annotation` to skip annotation of MACS2 and consensus peaks with HOMER - * `--skip_consensus_peaks` to skip consensus peak generation - * `--deseq2_vst` to use variance stabilizing transformation (VST) instead of regularized log transformation (rlog) with DESeq2 - * `--publish_dir_mode` to customise method of publishing results to output directory [nf-core/tools#585](https://github.com/nf-core/tools/issues/585) + * `--bwa_min_score` to set minimum alignment score for BWA MEM + * `--macs_fdr` to provide FDR threshold for MACS2 peak calling + * `--macs_pvalue` to provide p-value threshold for MACS2 peak calling + * `--skip_peak_qc` to skip MACS2 peak QC plot generation + * `--skip_peak_annotation` to skip annotation of MACS2 and consensus peaks with HOMER + * `--skip_consensus_peaks` to skip consensus peak generation + * `--deseq2_vst` to use variance stabilizing transformation (VST) instead of regularized log transformation (rlog) with DESeq2 + * `--publish_dir_mode` to customise method of publishing results to output directory [nf-core/tools#585](https://github.com/nf-core/tools/issues/585) ### `Removed` From a73693a97fe1c25e3782435506e4b5eead071ff8 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 27 Oct 2020 13:00:33 +0000 Subject: [PATCH 156/538] Fix markdownlint --- docs/README.md | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/docs/README.md b/docs/README.md index ac8a8b69c..68b828949 100644 --- a/docs/README.md +++ b/docs/README.md @@ -3,8 +3,8 @@ The nf-core/chipseq documentation is split into the following pages: * [Usage](usage.md) - * An overview of how the pipeline works, how to run it and a description of all of the different command-line flags. + * An overview of how the pipeline works, how to run it and a description of all of the different command-line flags. * [Output](output.md) - * An overview of the different results produced by the pipeline and how to interpret them. + * An overview of the different results produced by the pipeline and how to interpret them. You can find a lot more documentation about installing, configuring and running nf-core pipelines on the website: [https://nf-co.re](https://nf-co.re) From e0d44b54a99c4f766c80bda21780dac7d9b69202 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 27 Oct 2020 13:00:36 +0000 Subject: [PATCH 157/538] Fix markdownlint --- docs/output.md | 104 ++++++++++++++++++++++++------------------------- 1 file changed, 52 insertions(+), 52 deletions(-) diff --git a/docs/output.md b/docs/output.md index 374d8f344..721362ccd 100644 --- a/docs/output.md +++ b/docs/output.md @@ -26,9 +26,9 @@ The initial QC and alignments are performed at the library-level e.g. if the sam Output files * `fastqc/` - * `*_fastqc.html`: FastQC report containing quality metrics for read 1 (*and read2 if paired-end*) **before** adapter trimming. + * `*_fastqc.html`: FastQC report containing quality metrics for read 1 (*and read2 if paired-end*) **before** adapter trimming. * `fastqc/zips/` - * `*_fastqc.zip`: Zip archive containing the FastQC report, tab-delimited data file and plot images. + * `*_fastqc.zip`: Zip archive containing the FastQC report, tab-delimited data file and plot images. @@ -40,13 +40,13 @@ The initial QC and alignments are performed at the library-level e.g. if the sam Output files * `trim_galore/` - * `*fastq.gz`: If `--save_trimmed` is specified, FastQ files **after** adapter trimming will be placed in this directory. + * `*fastq.gz`: If `--save_trimmed` is specified, FastQ files **after** adapter trimming will be placed in this directory. * `trim_galore/logs/` - * `*.log`: Log file generated by Trim Galore!. + * `*.log`: Log file generated by Trim Galore!. * `trim_galore/fastqc/` - * `*_fastqc.html`: FastQC report containing quality metrics for read 1 (*and read2 if paired-end*) **after** adapter trimming. + * `*_fastqc.html`: FastQC report containing quality metrics for read 1 (*and read2 if paired-end*) **after** adapter trimming. * `trim_galore/fastqc/zips/` - * `*_fastqc.zip`: Zip archive containing the FastQC report, tab-delimited data file and plot images. + * `*_fastqc.zip`: Zip archive containing the FastQC report, tab-delimited data file and plot images. @@ -60,9 +60,9 @@ The initial QC and alignments are performed at the library-level e.g. if the sam Output files * `bwa/library/` - * `*.bam`: The files resulting from the alignment of individual libraries are not saved by default so this directory will not be present in your results. You can override this behaviour with the use of the `--save_align_intermeds` flag in which case it will contain the coordinate sorted alignment files in [`*.bam`](https://samtools.github.io/hts-specs/SAMv1.pdf) format. + * `*.bam`: The files resulting from the alignment of individual libraries are not saved by default so this directory will not be present in your results. You can override this behaviour with the use of the `--save_align_intermeds` flag in which case it will contain the coordinate sorted alignment files in [`*.bam`](https://samtools.github.io/hts-specs/SAMv1.pdf) format. * `bwa/library/samtools_stats/` - * SAMtools `.sorted.bam.flagstat`, `.sorted.bam.idxstats` and `.sorted.bam.stats` files generated from the alignment files. + * SAMtools `.sorted.bam.flagstat`, `.sorted.bam.idxstats` and `.sorted.bam.stats` files generated from the alignment files. > **NB:** File names in the resulting directory (i.e. `bwa/library/`) will have the '`.Lb.`' suffix. @@ -82,16 +82,16 @@ The library-level alignments associated with the same sample are merged and subs Output files * `bwa/mergedLibrary/` - * `*.bam`: Merged library-level, coordinate sorted `*.bam` files after the marking of duplicates, and filtering based on various criteria. The file suffix for the final filtered files will be `*.mLb.clN.*`. If you specify the `--save_align_intermeds` parameter then two additional sets of files will be present. These represent the unfiltered alignments with duplicates marked (`*.mLb.mkD.*`), and in the case of paired-end datasets the filtered alignments before the removal of orphan read pairs (`*.mLb.flT.*`). + * `*.bam`: Merged library-level, coordinate sorted `*.bam` files after the marking of duplicates, and filtering based on various criteria. The file suffix for the final filtered files will be `*.mLb.clN.*`. If you specify the `--save_align_intermeds` parameter then two additional sets of files will be present. These represent the unfiltered alignments with duplicates marked (`*.mLb.mkD.*`), and in the case of paired-end datasets the filtered alignments before the removal of orphan read pairs (`*.mLb.flT.*`). * `bwa/mergedLibrary/samtools_stats/` - * SAMtools `*.flagstat`, `*.idxstats` and `*.stats` files generated from the alignment files. + * SAMtools `*.flagstat`, `*.idxstats` and `*.stats` files generated from the alignment files. * `bwa/mergedLibrary/picard_metrics/` - * `*_metrics`: Alignment QC files from picard CollectMultipleMetrics. - * `*.metrics.txt`: Metrics file from MarkDuplicates. + * `*_metrics`: Alignment QC files from picard CollectMultipleMetrics. + * `*.metrics.txt`: Metrics file from MarkDuplicates. * `bwa/mergedLibrary/picard_metrics/pdf/` - * `*.pdf`: Alignment QC plot files from picard CollectMultipleMetrics. + * `*.pdf`: Alignment QC plot files from picard CollectMultipleMetrics. * `bwa/mergedLibrary/preseq/` - * `*.ccurve.txt`: Preseq expected future yield file. + * `*.ccurve.txt`: Preseq expected future yield file. > **NB:** File names in the resulting directory (i.e. `bwa/mergedLibrary/`) will have the '`.mLb.`' suffix. @@ -115,7 +115,7 @@ The [Preseq](http://smithlabresearch.org/software/preseq/) package is aimed at p Output files * `bwa/mergedLibrary/bigwig/` - * `*.bigWig`: Normalised bigWig files scaled to 1 million mapped reads. + * `*.bigWig`: Normalised bigWig files scaled to 1 million mapped reads. @@ -127,12 +127,12 @@ The [bigWig](https://genome.ucsc.edu/goldenpath/help/bigWig.html) format is in a Output files * `bwa/mergedLibrary/phantompeakqualtools/` - * `*.spp.out`, `*.spp.pdf`: phantompeakqualtools output files. - * `*_mqc.tsv`: MultiQC custom content files. + * `*.spp.out`, `*.spp.pdf`: phantompeakqualtools output files. + * `*_mqc.tsv`: MultiQC custom content files. * `bwa/mergedLibrary/deepTools/plotFingerprint/` - * `*.plotFingerprint.pdf`, `*.plotFingerprint.qcmetrics.txt`, `*.plotFingerprint.raw.txt`: plotFingerprint output files. + * `*.plotFingerprint.pdf`, `*.plotFingerprint.qcmetrics.txt`, `*.plotFingerprint.raw.txt`: plotFingerprint output files. * `bwa/mergedLibrary/deepTools/plotProfile/` - * `*.computeMatrix.mat.gz`, `*.computeMatrix.vals.mat.tab`, `*.plotProfile.pdf`, `*.plotProfile.tab`, `*.plotHeatmap.pdf`, `*.plotHeatmap.mat.tab`: plotProfile output files. + * `*.computeMatrix.mat.gz`, `*.computeMatrix.vals.mat.tab`, `*.plotProfile.pdf`, `*.plotProfile.tab`, `*.plotHeatmap.pdf`, `*.plotHeatmap.mat.tab`: plotProfile output files. @@ -162,12 +162,12 @@ The results from deepTools plotProfile gives you a quick visualisation for the g Output files * `bwa/mergedLibrary/macs//` - * `*.xls`, `*.broadPeak` or `*.narrowPeak`, `*.gappedPeak`, `*summits.bed`: MACS2 output files - the files generated will depend on whether MACS2 has been run in *narrowPeak* or *broadPeak* mode. - * `*.annotatePeaks.txt`: HOMER peak-to-gene annotation file. + * `*.xls`, `*.broadPeak` or `*.narrowPeak`, `*.gappedPeak`, `*summits.bed`: MACS2 output files - the files generated will depend on whether MACS2 has been run in *narrowPeak* or *broadPeak* mode. + * `*.annotatePeaks.txt`: HOMER peak-to-gene annotation file. * `bwa/mergedLibrary/macs//qc/` - * `macs_peak.plots.pdf`: QC plots for MACS2 peaks. - * `macs_annotatePeaks.plots.pdf`: QC plots for peak-to-gene feature annotation. - * `*.FRiP_mqc.tsv`, `*.count_mqc.tsv`, `macs_annotatePeaks.summary_mqc.tsv`: MultiQC custom-content files for FRiP score, peak count and peak-to-gene ratios. + * `macs_peak.plots.pdf`: QC plots for MACS2 peaks. + * `macs_annotatePeaks.plots.pdf`: QC plots for peak-to-gene feature annotation. + * `*.FRiP_mqc.tsv`, `*.count_mqc.tsv`, `macs_annotatePeaks.summary_mqc.tsv`: MultiQC custom-content files for FRiP score, peak count and peak-to-gene ratios. > **NB:** `` in the directory structure above corresponds to the type of peak that you have specified to call with MACS2 i.e. `broadPeak` or `narrowPeak`. If you so wish, you can call both narrow and broad peaks without redoing the preceding steps in the pipeline such as the alignment and filtering. For example, if you already have broad peaks then just add `--narrow_peak -resume` to the command you used to run the pipeline, and these will be called too! However, resuming the pipeline will only be possible if you have not deleted the `work/` directory generated by the pipeline. @@ -191,13 +191,13 @@ Various QC plots per sample including number of peaks, fold-change distribution, Output files * `bwa/mergedLibrary/macs//consensus/` - * `*.bed`: Consensus peak-set across all samples in BED format. - * `*.saf`: Consensus peak-set across all samples in SAF format. Required by featureCounts for read quantification. - * `*.featureCounts.txt`: Read counts across all samples relative to consensus peak-set. - * `*.annotatePeaks.txt`: HOMER peak-to-gene annotation file for consensus peaks. - * `*.boolean.annotatePeaks.txt`: Spreadsheet representation of consensus peak-set across samples **with** gene annotation columns. The columns from individual peak files are included in this file along with the ability to filter peaks based on their presence or absence in multiple replicates/conditions. - * `*.boolean.txt`: Spreadsheet representation of consensus peak-set across samples **without** gene annotation columns. Same as file above but without annotation columns. - * `*.boolean.intersect.plot.pdf`, `*.boolean.intersect.txt`: [UpSetR](https://cran.r-project.org/web/packages/UpSetR/README.html) files to illustrate peak intersection. + * `*.bed`: Consensus peak-set across all samples in BED format. + * `*.saf`: Consensus peak-set across all samples in SAF format. Required by featureCounts for read quantification. + * `*.featureCounts.txt`: Read counts across all samples relative to consensus peak-set. + * `*.annotatePeaks.txt`: HOMER peak-to-gene annotation file for consensus peaks. + * `*.boolean.annotatePeaks.txt`: Spreadsheet representation of consensus peak-set across samples **with** gene annotation columns. The columns from individual peak files are included in this file along with the ability to filter peaks based on their presence or absence in multiple replicates/conditions. + * `*.boolean.txt`: Spreadsheet representation of consensus peak-set across samples **without** gene annotation columns. Same as file above but without annotation columns. + * `*.boolean.intersect.plot.pdf`, `*.boolean.intersect.txt`: [UpSetR](https://cran.r-project.org/web/packages/UpSetR/README.html) files to illustrate peak intersection. @@ -219,18 +219,18 @@ The [featureCounts](http://bioinf.wehi.edu.au/featureCounts/) tool is used to co Output files * `bwa/mergedLibrary/macs//consensus//deseq2/` - * `*.results.txt`: Spreadsheet containing differential binding results across all consensus peaks and all comparisons. - * `*.plots.pdf`: File containing PCA and hierarchical clustering plots. - * `*.log`: Log file with information for number of differentially bound intervals at different FDR and fold-change thresholds for each comparison. - * `*.dds.rld.RData`: File containing R `dds` and `rld` objects generated by DESeq2. - * `R_sessionInfo.log`: File containing information about R, the OS and attached or loaded packages. + * `*.results.txt`: Spreadsheet containing differential binding results across all consensus peaks and all comparisons. + * `*.plots.pdf`: File containing PCA and hierarchical clustering plots. + * `*.log`: Log file with information for number of differentially bound intervals at different FDR and fold-change thresholds for each comparison. + * `*.dds.rld.RData`: File containing R `dds` and `rld` objects generated by DESeq2. + * `R_sessionInfo.log`: File containing information about R, the OS and attached or loaded packages. * `bwa/mergedLibrary/macs//consensus///` - * `*.results.txt`: Spreadsheet containing comparison-specific DESeq2 output for differential binding results across all peaks. - * `*FDR0.01.results.txt`, `*FDR0.05.results.txt`: Subset of above file for peaks that pass FDR <= 0.01 and FDR <= 0.05. - * `*FDR0.01.results.bed`, `*FDR0.05.results.bed`: BED files for peaks that pass FDR <= 0.01 and FDR <= 0.05. - * `*deseq2.plots.pdf`: MA, Volcano, clustering and scatterplots at FDR <= 0.01 and FDR <= 0.05. + * `*.results.txt`: Spreadsheet containing comparison-specific DESeq2 output for differential binding results across all peaks. + * `*FDR0.01.results.txt`, `*FDR0.05.results.txt`: Subset of above file for peaks that pass FDR <= 0.01 and FDR <= 0.05. + * `*FDR0.01.results.bed`, `*FDR0.05.results.bed`: BED files for peaks that pass FDR <= 0.01 and FDR <= 0.05. + * `*deseq2.plots.pdf`: MA, Volcano, clustering and scatterplots at FDR <= 0.01 and FDR <= 0.05. * `bwa/mergedLibrary/macs//consensus//sizeFactors/` - * `*.txt`, `*.RData`: Files containing DESeq2 sizeFactors per sample. + * `*.txt`, `*.RData`: Files containing DESeq2 sizeFactors per sample. @@ -260,9 +260,9 @@ By default, all possible pairwise comparisons across the groups from a particula Output files * `multiqc//` - * `multiqc_report.html`: A standalone HTML file that can be viewed in your web browser. - * `multiqc_data/`: Directory containing parsed statistics from the different tools used in the pipeline. - * `multiqc_plots/`: Directory containing static images from the report in various formats. + * `multiqc_report.html`: A standalone HTML file that can be viewed in your web browser. + * `multiqc_data/`: Directory containing parsed statistics from the different tools used in the pipeline. + * `multiqc_plots/`: Directory containing static images from the report in various formats. @@ -278,8 +278,8 @@ The pipeline has special steps which also allow the software versions to be repo Output files * `igv//` - * `igv_session.xml`: Session file that can be directly loaded into IGV. - * `igv_files.txt`: File containing a listing of the files used to create the IGV session. + * `igv_session.xml`: Session file that can be directly loaded into IGV. + * `igv_files.txt`: File containing a listing of the files used to create the IGV session. @@ -303,9 +303,9 @@ Once installed, open IGV, go to `File > Open Session` and select the `igv_sessio Output files * `genome/` - * A number of genome-specific files are generated by the pipeline in order to aid in the filtering of the data, and because they are required by standard tools such as BEDTools. These can be found in this directory along with the genome fasta file which is required by IGV. If using a genome from AWS iGenomes and if it exists a `README.txt` file containing information about the annotation version will also be saved in this directory. + * A number of genome-specific files are generated by the pipeline in order to aid in the filtering of the data, and because they are required by standard tools such as BEDTools. These can be found in this directory along with the genome fasta file which is required by IGV. If using a genome from AWS iGenomes and if it exists a `README.txt` file containing information about the annotation version will also be saved in this directory. * `genome/BWAIndex/` - * If the `--save_reference` parameter is provided then the alignment indices generated by the pipeline will be saved in this directory. This can be quite a time-consuming process so it permits their reuse for future runs of the pipeline or for other purposes. + * If the `--save_reference` parameter is provided then the alignment indices generated by the pipeline will be saved in this directory. This can be quite a time-consuming process so it permits their reuse for future runs of the pipeline or for other purposes. @@ -317,10 +317,10 @@ Reference genome-specific files can be useful to keep for the downstream process Output files * `pipeline_info/` - * `pipeline_report.html`, `pipeline_report.txt`, `software_versions.csv`: Reports generated by the pipeline. - * `execution_report.html`, `execution_timeline.html`, `execution_trace.txt`, `pipeline_dag.svg`: Reports generated by Nextflow. - * `design_reads.csv`, `design_controls.csv`: Reformatted design files used as input to the pipeline. - * `results_description.html`: Documentation for interpretation of results in HTML format. + * `pipeline_report.html`, `pipeline_report.txt`, `software_versions.csv`: Reports generated by the pipeline. + * `execution_report.html`, `execution_timeline.html`, `execution_trace.txt`, `pipeline_dag.svg`: Reports generated by Nextflow. + * `design_reads.csv`, `design_controls.csv`: Reformatted design files used as input to the pipeline. + * `results_description.html`: Documentation for interpretation of results in HTML format. From 8b484b26ea030972c05de7deadf789180b9ce394 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Tue, 27 Oct 2020 13:00:38 +0000 Subject: [PATCH 158/538] Fix markdownlint --- docs/usage.md | 22 +++++++++++----------- 1 file changed, 11 insertions(+), 11 deletions(-) diff --git a/docs/usage.md b/docs/usage.md index 661a4ae0a..7b9c7474d 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -143,21 +143,21 @@ They are loaded in sequence, so later profiles can overwrite earlier profiles. If `-profile` is not specified, the pipeline will run locally and expect all software to be installed and available on the `PATH`. This is _not_ recommended. * `docker` - * A generic configuration profile to be used with [Docker](https://docker.com/) - * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Docker](https://docker.com/) + * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) * `singularity` - * A generic configuration profile to be used with [Singularity](https://sylabs.io/docs/) - * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Singularity](https://sylabs.io/docs/) + * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) * `podman` - * A generic configuration profile to be used with [Podman](https://podman.io/) - * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Podman](https://podman.io/) + * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) * `conda` - * Please only use Conda as a last resort i.e. when it's not possible to run the pipeline with Docker, Singularity or Podman. - * A generic configuration profile to be used with [Conda](https://conda.io/docs/) - * Pulls most software from [Bioconda](https://bioconda.github.io/) + * Please only use Conda as a last resort i.e. when it's not possible to run the pipeline with Docker, Singularity or Podman. + * A generic configuration profile to be used with [Conda](https://conda.io/docs/) + * Pulls most software from [Bioconda](https://bioconda.github.io/) * `test` - * A profile with a complete configuration for automated testing - * Includes links to test data so needs no other parameters + * A profile with a complete configuration for automated testing + * Includes links to test data so needs no other parameters ### `-resume` From 120953a02e27b13b101db0a8e8c59c1d5cafddf6 Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Thu, 19 Nov 2020 13:47:35 +0000 Subject: [PATCH 159/538] Template update for nf-core/tools version 1.12 --- .github/ISSUE_TEMPLATE/bug_report.md | 7 ++++- .github/ISSUE_TEMPLATE/config.yml | 8 +++++ .github/ISSUE_TEMPLATE/feature_request.md | 6 ++++ .github/workflows/awsfulltest.yml | 7 +++-- .github/workflows/awstest.yml | 2 +- .github/workflows/branch.yml | 2 +- .github/workflows/ci.yml | 12 +++++--- .github/workflows/linting.yml | 13 ++++++-- .github/workflows/linting_comment.yml | 29 ++++++++++++++++++ .github/workflows/push_dockerhub_dev.yml | 28 +++++++++++++++++ ...ckerhub.yml => push_dockerhub_release.yml} | 15 ++------- Dockerfile | 2 +- README.md | 2 +- assets/nf-core-chipseq_logo.png | Bin 12485 -> 519 bytes assets/sendmail_template.txt | 2 +- main.nf | 14 ++++----- nextflow.config | 5 +-- 17 files changed, 116 insertions(+), 38 deletions(-) create mode 100644 .github/ISSUE_TEMPLATE/config.yml create mode 100644 .github/workflows/linting_comment.yml create mode 100644 .github/workflows/push_dockerhub_dev.yml rename .github/workflows/{push_dockerhub.yml => push_dockerhub_release.yml} (68%) diff --git a/.github/ISSUE_TEMPLATE/bug_report.md b/.github/ISSUE_TEMPLATE/bug_report.md index dfb5c2cbf..ebbccc285 100644 --- a/.github/ISSUE_TEMPLATE/bug_report.md +++ b/.github/ISSUE_TEMPLATE/bug_report.md @@ -1,10 +1,15 @@ +--- +name: Bug report +about: Report something that is broken or incorrect +labels: bug +--- + diff --git a/.github/ISSUE_TEMPLATE/config.yml b/.github/ISSUE_TEMPLATE/config.yml new file mode 100644 index 000000000..6b4360344 --- /dev/null +++ b/.github/ISSUE_TEMPLATE/config.yml @@ -0,0 +1,8 @@ +blank_issues_enabled: false +contact_links: + - name: Join nf-core + url: https://nf-co.re/join + about: Please join the nf-core community here + - name: "Slack #chipseq channel" + url: https://nfcore.slack.com/channels/chipseq + about: Discussion about the nf-core/chipseq pipeline diff --git a/.github/ISSUE_TEMPLATE/feature_request.md b/.github/ISSUE_TEMPLATE/feature_request.md index 1f5a0971a..4a1e82612 100644 --- a/.github/ISSUE_TEMPLATE/feature_request.md +++ b/.github/ISSUE_TEMPLATE/feature_request.md @@ -1,3 +1,9 @@ +--- +name: Feature request +about: Suggest an idea for the nf-core website +labels: enhancement +--- + +## Check Documentation + +I have checked the following places for your error: + +- [ ] [nf-core website: troubleshooting](https://nf-co.re/usage/troubleshooting) +- [ ] [nf-core/chipseq pipeline documentation](https://nf-co.re/nf-core/chipseq/usage) + ## Description of the bug @@ -28,6 +35,13 @@ Steps to reproduce the behaviour: +## Log files + +Have you provided the following extra information/files: + +- [ ] The command used to run the pipeline +- [ ] The `.nextflow.log` file + ## System - Hardware: diff --git a/.github/PULL_REQUEST_TEMPLATE.md b/.github/PULL_REQUEST_TEMPLATE.md index e910ffbc7..f5062d15c 100644 --- a/.github/PULL_REQUEST_TEMPLATE.md +++ b/.github/PULL_REQUEST_TEMPLATE.md @@ -13,8 +13,14 @@ Learn more about contributing: [CONTRIBUTING.md](https://github.com/nf-core/chip ## PR checklist -- [ ] This comment contains a description of changes (with reason) -- [ ] `CHANGELOG.md` is updated +- [ ] This comment contains a description of changes (with reason). - [ ] If you've fixed a bug or added code that should be tested, add tests! -- [ ] Documentation in `docs` is updated -- [ ] If necessary, also make a PR on the [nf-core/chipseq branch on the nf-core/test-datasets repo](https://github.com/nf-core/test-datasets/pull/new/nf-core/chipseq) + - [ ] If you've added a new tool - add to the software_versions process and a regex to `scrape_software_versions.py` + - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) + - [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. +- [ ] Make sure your code lints (`nf-core lint .`). +- [ ] Ensure the test suite passes (`nextflow run . -profile test,docker`). +- [ ] Usage Documentation in `docs/usage.md` is updated. +- [ ] Output Documentation in `docs/output.md` is updated. +- [ ] `CHANGELOG.md` is updated. +- [ ] `README.md` is updated (including new tool citations and authors/contributors). diff --git a/.github/markdownlint.yml b/.github/markdownlint.yml index 96b12a703..8d7eb53b0 100644 --- a/.github/markdownlint.yml +++ b/.github/markdownlint.yml @@ -1,5 +1,12 @@ # Markdownlint configuration file -default: true, +default: true line-length: false no-duplicate-header: siblings_only: true +no-inline-html: + allowed_elements: + - img + - p + - kbd + - details + - summary diff --git a/Dockerfile b/Dockerfile index daff7b6c6..0c5ae5e88 100644 --- a/Dockerfile +++ b/Dockerfile @@ -1,4 +1,4 @@ -FROM nfcore/base:1.12 +FROM nfcore/base:1.12.1 LABEL authors="Philip Ewels" \ description="Docker image containing all software requirements for the nf-core/chipseq pipeline" diff --git a/README.md b/README.md index 16aa16279..b368f5d77 100644 --- a/README.md +++ b/README.md @@ -12,6 +12,9 @@ ## Introduction + +**nf-core/chipseq** is a bioinformatics best-practise analysis pipeline for + The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool to run tasks across multiple compute infrastructures in a very portable manner. It comes with docker containers making installation trivial and results highly reproducible. ## Quick Start @@ -38,6 +41,15 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool See [usage docs](https://nf-co.re/chipseq/usage) for all of the available options when running the pipeline. +## Pipeline Summary + +By default, the pipeline currently performs the following: + + + +* Sequencing quality control (`FastQC`) +* Overall pipeline run summaries (`MultiQC`) + ## Documentation The nf-core/chipseq pipeline comes with documentation about the pipeline: [usage](https://nf-co.re/chipseq/usage) and [output](https://nf-co.re/chipseq/output). @@ -48,13 +60,18 @@ The nf-core/chipseq pipeline comes with documentation about the pipeline: [usage nf-core/chipseq was originally written by Philip Ewels. +We thank the following people for their extensive assistance in the development +of this pipeline: + + + ## Contributions and Support If you would like to contribute to this pipeline, please see the [contributing guidelines](.github/CONTRIBUTING.md). For further information or help, don't hesitate to get in touch on the [Slack `#chipseq` channel](https://nfcore.slack.com/channels/chipseq) (you can join with [this invite](https://nf-co.re/join/slack)). -## Citation +## Citations @@ -67,3 +84,7 @@ You can cite the `nf-core` publication as follows: > > _Nat Biotechnol._ 2020 Feb 13. doi: [10.1038/s41587-020-0439-x](https://dx.doi.org/10.1038/s41587-020-0439-x). > ReadCube: [Full Access Link](https://rdcu.be/b1GjZ) + +In addition, references of tools and data used in this pipeline are as follows: + + diff --git a/assets/nf-core-chipseq_logo.png b/assets/nf-core-chipseq_logo.png index 1993002f28494136e88a278dbbfcb5170b757b3e..e123d62bb8c81e893790d2f248912373a13f5b66 100644 GIT binary patch literal 110285 zcmeFXhgZ{C_dOiI5tXK*BGP7%BGP+J7)KNX0tzY}M4I#_EtKG(AW|X;y{a@30#ZT` zMMfZ0r6lwsozP1Hge30=N9Xzd5AXM`Wm&qox%ZrX_SyT~MBUTZW;=7`3oJc83c=9X{HRe8B&y@}tlE6%`$=cv5>836b}!x*FMFwuPp85=C9ZN__~I|+w-J&> 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html_template.toString() // Render the sendmail template - def smail_fields = [ email: email_address, subject: subject, email_txt: email_txt, email_html: email_html, baseDir: "$projectDir", mqcFile: mqc_report, mqcMaxSize: params.max_multiqc_email_size.toBytes() ] + def smail_fields = [ email: email_address, subject: subject, email_txt: email_txt, email_html: email_html, projectDir: "$projectDir", mqcFile: mqc_report, mqcMaxSize: params.max_multiqc_email_size.toBytes() ] def sf = new File("$projectDir/assets/sendmail_template.txt") def sendmail_template = engine.createTemplate(sf).make(smail_fields) def sendmail_html = sendmail_template.toString() From a4166d4df04681b2b85607c1ac4188def3dafa30 Mon Sep 17 00:00:00 2001 From: drpatelh Date: Wed, 16 Dec 2020 17:59:22 +0000 Subject: [PATCH 163/538] Update CHANGELOG --- CHANGELOG.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 0ccf1521c..e58d024d7 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -9,7 +9,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 * Move template boilerplate code to Groovy `lib/` * Implement pipeline in DSL2 -* Update pipeline template to nf-core/tools `1.12` +* Update pipeline template to nf-core/tools `1.12.1` ### `Fixed` From a1f1d1a02dbaaa7cfaefa1ad0d4a810543d0d1ae Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Wed, 16 Dec 2020 21:01:55 +0000 Subject: [PATCH 164/538] Update README.md --- README.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/README.md b/README.md index caeb2baf0..b8c3918c1 100644 --- a/README.md +++ b/README.md @@ -97,4 +97,4 @@ An extensive list of references for the tools used by the pipeline can be found > > Philip Ewels, Alexander Peltzer, Sven Fillinger, Harshil Patel, Johannes Alneberg, Andreas Wilm, Maxime Ulysse Garcia, Paolo Di Tommaso & Sven Nahnsen. > -> _Nat Biotechnol._ 2020 Feb 13. doi: [10.1038/s41587-020-0439-x](https://dx.doi.org/10.1038/s41587-020-0439-x). \ No newline at end of file +> _Nat Biotechnol._ 2020 Feb 13. doi: [10.1038/s41587-020-0439-x](https://dx.doi.org/10.1038/s41587-020-0439-x). From 87b2a24f8a831195213b1f3e8e9fa7c726804ce4 Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Thu, 18 Mar 2021 12:05:43 +0000 Subject: [PATCH 165/538] Template update for nf-core/tools version 1.13 --- .github/.dockstore.yml | 1 + .github/CONTRIBUTING.md | 4 +- .github/ISSUE_TEMPLATE/bug_report.md | 2 +- .github/ISSUE_TEMPLATE/feature_request.md | 2 +- .github/PULL_REQUEST_TEMPLATE.md | 6 +- .github/workflows/awsfulltest.yml | 17 +- .github/workflows/awstest.yml | 17 +- .github/workflows/branch.yml | 7 +- .github/workflows/linting.yml | 2 +- CODE_OF_CONDUCT.md | 117 ++++- Dockerfile | 6 +- README.md | 7 +- assets/email_template.html | 1 - assets/nf-core-chipseq_logo.png | Bin 110285 -> 17874 bytes bin/markdown_to_html.py | 0 bin/scrape_software_versions.py | 0 conf/base.config | 2 +- conf/test.config | 2 + conf/test_full.config | 2 + docs/images/nf-core-chipseq_logo.png | Bin 110285 -> 34565 bytes docs/output.md | 4 - docs/usage.md | 12 +- lib/Headers.groovy | 43 ++ lib/NfcoreSchema.groovy | 571 ++++++++++++++++++++++ lib/nfcore_external_java_deps.jar | Bin 0 -> 2291171 bytes main.nf | 143 ++---- nextflow.config | 42 +- nextflow_schema.json | 27 +- 28 files changed, 866 insertions(+), 171 deletions(-) mode change 100755 => 100644 bin/markdown_to_html.py mode change 100755 => 100644 bin/scrape_software_versions.py create mode 100644 lib/Headers.groovy create mode 100644 lib/NfcoreSchema.groovy create mode 100644 lib/nfcore_external_java_deps.jar diff --git a/.github/.dockstore.yml b/.github/.dockstore.yml index 030138a0c..191fabd22 100644 --- a/.github/.dockstore.yml +++ b/.github/.dockstore.yml @@ -3,3 +3,4 @@ version: 1.2 workflows: - subclass: nfl primaryDescriptorPath: /nextflow.config + publish: True diff --git a/.github/CONTRIBUTING.md b/.github/CONTRIBUTING.md index 32de1a44b..81a0933ea 100644 --- a/.github/CONTRIBUTING.md +++ b/.github/CONTRIBUTING.md @@ -69,7 +69,7 @@ If you wish to contribute a new step, please use the following coding standards: 2. Write the process block (see below). 3. Define the output channel if needed (see below). 4. Add any new flags/options to `nextflow.config` with a default (see below). -5. Add any new flags/options to `nextflow_schema.json` with help text (with `nf-core schema build .`) +5. Add any new flags/options to `nextflow_schema.json` with help text (with `nf-core schema build .`). 6. Add any new flags/options to the help message (for integer/text parameters, print to help the corresponding `nextflow.config` parameter). 7. Add sanity checks for all relevant parameters. 8. Add any new software to the `scrape_software_versions.py` script in `bin/` and the version command to the `scrape_software_versions` process in `main.nf`. @@ -87,7 +87,7 @@ Once there, use `nf-core schema build .` to add to `nextflow_schema.json`. ### Default processes resource requirements -Sensible defaults for process resource requirements (CPUs / memory / time) for a process should be defined in `conf/base.config`. These should generally be specified generic with `withLabel:` selectors so they can be shared across multiple processes/steps of the pipeline. A nf-core standard set of labels that should be followed where possible can be seen in the [nf-core pipeline template](https://github.com/nf-core/tools/blob/master/nf_core/pipeline-template/%7B%7Bcookiecutter.name_noslash%7D%7D/conf/base.config), which has the default process as a single core-process, and then different levels of multi-core configurations for increasingly large memory requirements defined with standardised labels. +Sensible defaults for process resource requirements (CPUs / memory / time) for a process should be defined in `conf/base.config`. These should generally be specified generic with `withLabel:` selectors so they can be shared across multiple processes/steps of the pipeline. A nf-core standard set of labels that should be followed where possible can be seen in the [nf-core pipeline template](https://github.com/nf-core/tools/blob/master/nf_core/pipeline-template/conf/base.config), which has the default process as a single core-process, and then different levels of multi-core configurations for increasingly large memory requirements defined with standardised labels. The process resources can be passed on to the tool dynamically within the process with the `${task.cpu}` and `${task.memory}` variables in the `script:` block. diff --git a/.github/ISSUE_TEMPLATE/bug_report.md b/.github/ISSUE_TEMPLATE/bug_report.md index 7edcb791e..7e6f4d86a 100644 --- a/.github/ISSUE_TEMPLATE/bug_report.md +++ b/.github/ISSUE_TEMPLATE/bug_report.md @@ -55,7 +55,7 @@ Have you provided the following extra information/files: ## Container engine -- Engine: +- Engine: - version: - Image tag: diff --git a/.github/ISSUE_TEMPLATE/feature_request.md b/.github/ISSUE_TEMPLATE/feature_request.md index 4a1e82612..15aceab96 100644 --- a/.github/ISSUE_TEMPLATE/feature_request.md +++ b/.github/ISSUE_TEMPLATE/feature_request.md @@ -1,6 +1,6 @@ --- name: Feature request -about: Suggest an idea for the nf-core website +about: Suggest an idea for the nf-core/chipseq pipeline labels: enhancement --- diff --git a/.github/PULL_REQUEST_TEMPLATE.md b/.github/PULL_REQUEST_TEMPLATE.md index f5062d15c..f1d89ef72 100644 --- a/.github/PULL_REQUEST_TEMPLATE.md +++ b/.github/PULL_REQUEST_TEMPLATE.md @@ -15,9 +15,9 @@ Learn more about contributing: [CONTRIBUTING.md](https://github.com/nf-core/chip - [ ] This comment contains a description of changes (with reason). - [ ] If you've fixed a bug or added code that should be tested, add tests! - - [ ] If you've added a new tool - add to the software_versions process and a regex to `scrape_software_versions.py` - - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) - - [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. + - [ ] If you've added a new tool - add to the software_versions process and a regex to `scrape_software_versions.py` + - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) + - [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. - [ ] Make sure your code lints (`nf-core lint .`). - [ ] Ensure the test suite passes (`nextflow run . -profile test,docker`). - [ ] Usage Documentation in `docs/usage.md` is updated. diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index f763c9f46..3f1420d3b 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -9,6 +9,16 @@ on: types: [completed] workflow_dispatch: + +env: + AWS_ACCESS_KEY_ID: ${{ secrets.AWS_ACCESS_KEY_ID }} + AWS_SECRET_ACCESS_KEY: ${{ secrets.AWS_SECRET_ACCESS_KEY }} + TOWER_ACCESS_TOKEN: ${{ secrets.AWS_TOWER_TOKEN }} + AWS_JOB_DEFINITION: ${{ secrets.AWS_JOB_DEFINITION }} + AWS_JOB_QUEUE: ${{ secrets.AWS_JOB_QUEUE }} + AWS_S3_BUCKET: ${{ secrets.AWS_S3_BUCKET }} + + jobs: run-awstest: name: Run AWS full tests @@ -27,13 +37,6 @@ jobs: # Add full size test data (but still relatively small datasets for few samples) # on the `test_full.config` test runs with only one set of parameters # Then specify `-profile test_full` instead of `-profile test` on the AWS batch command - env: - AWS_ACCESS_KEY_ID: ${{ secrets.AWS_ACCESS_KEY_ID }} - AWS_SECRET_ACCESS_KEY: ${{ secrets.AWS_SECRET_ACCESS_KEY }} - TOWER_ACCESS_TOKEN: ${{ secrets.AWS_TOWER_TOKEN }} - AWS_JOB_DEFINITION: ${{ secrets.AWS_JOB_DEFINITION }} - AWS_JOB_QUEUE: ${{ secrets.AWS_JOB_QUEUE }} - AWS_S3_BUCKET: ${{ secrets.AWS_S3_BUCKET }} run: | aws batch submit-job \ --region eu-west-1 \ diff --git a/.github/workflows/awstest.yml b/.github/workflows/awstest.yml index 84b6dbb00..83bf06058 100644 --- a/.github/workflows/awstest.yml +++ b/.github/workflows/awstest.yml @@ -6,6 +6,16 @@ name: nf-core AWS test on: workflow_dispatch: + +env: + AWS_ACCESS_KEY_ID: ${{ secrets.AWS_ACCESS_KEY_ID }} + AWS_SECRET_ACCESS_KEY: ${{ secrets.AWS_SECRET_ACCESS_KEY }} + TOWER_ACCESS_TOKEN: ${{ secrets.AWS_TOWER_TOKEN }} + AWS_JOB_DEFINITION: ${{ secrets.AWS_JOB_DEFINITION }} + AWS_JOB_QUEUE: ${{ secrets.AWS_JOB_QUEUE }} + AWS_S3_BUCKET: ${{ secrets.AWS_S3_BUCKET }} + + jobs: run-awstest: name: Run AWS tests @@ -23,13 +33,6 @@ jobs: # TODO nf-core: You can customise CI pipeline run tests as required # For example: adding multiple test runs with different parameters # Remember that you can parallelise this by using strategy.matrix - env: - AWS_ACCESS_KEY_ID: ${{ secrets.AWS_ACCESS_KEY_ID }} - AWS_SECRET_ACCESS_KEY: ${{ secrets.AWS_SECRET_ACCESS_KEY }} - TOWER_ACCESS_TOKEN: ${{ secrets.AWS_TOWER_TOKEN }} - AWS_JOB_DEFINITION: ${{ secrets.AWS_JOB_DEFINITION }} - AWS_JOB_QUEUE: ${{ secrets.AWS_JOB_QUEUE }} - AWS_S3_BUCKET: ${{ secrets.AWS_S3_BUCKET }} run: | aws batch submit-job \ --region eu-west-1 \ diff --git a/.github/workflows/branch.yml b/.github/workflows/branch.yml index 17179b678..d737ff7c6 100644 --- a/.github/workflows/branch.yml +++ b/.github/workflows/branch.yml @@ -13,7 +13,7 @@ jobs: - name: Check PRs if: github.repository == 'nf-core/chipseq' run: | - { [[ ${{github.event.pull_request.head.repo.full_name}} == nf-core/chipseq ]] && [[ $GITHUB_HEAD_REF = "dev" ]]; } || [[ $GITHUB_HEAD_REF == "patch" ]] + { [[ ${{github.event.pull_request.head.repo.full_name }} == nf-core/chipseq ]] && [[ $GITHUB_HEAD_REF = "dev" ]]; } || [[ $GITHUB_HEAD_REF == "patch" ]] # If the above check failed, post a comment on the PR explaining the failure @@ -25,11 +25,12 @@ jobs: message: | Hi @${{ github.event.pull_request.user.login }}, - It looks like this pull-request is has been made against the ${{github.event.pull_request.head.repo.full_name}} `master` branch. + It looks like this pull-request is has been made against the ${{github.event.pull_request.base.repo.full_name }} `master` branch. The `master` branch on nf-core repositories should always contain code from the latest release. - Because of this, PRs to `master` are only allowed if they come from the ${{github.event.pull_request.head.repo.full_name}} `dev` branch. + Because of this, PRs to `master` are only allowed if they come from the ${{github.event.pull_request.base.repo.full_name }} `dev` branch. You do not need to close this PR, you can change the target branch to `dev` by clicking the _"Edit"_ button at the top of this page. + Note that even after this, the test will continue to show as failing until you push a new commit. Thanks again for your contribution! repo-token: ${{ secrets.GITHUB_TOKEN }} diff --git a/.github/workflows/linting.yml b/.github/workflows/linting.yml index bef81e619..58e281df6 100644 --- a/.github/workflows/linting.yml +++ b/.github/workflows/linting.yml @@ -69,7 +69,7 @@ jobs: if: ${{ always() }} uses: actions/upload-artifact@v2 with: - name: linting-log-file + name: linting-logs path: | lint_log.txt lint_results.md diff --git a/CODE_OF_CONDUCT.md b/CODE_OF_CONDUCT.md index 405fb1bfd..f4fd052f1 100644 --- a/CODE_OF_CONDUCT.md +++ b/CODE_OF_CONDUCT.md @@ -1,46 +1,111 @@ -# Contributor Covenant Code of Conduct +# Code of Conduct at nf-core (v1.0) ## Our Pledge -In the interest of fostering an open and welcoming environment, we as contributors and maintainers pledge to making participation in our project and our community a harassment-free experience for everyone, regardless of age, body size, disability, ethnicity, gender identity and expression, level of experience, nationality, personal appearance, race, religion, or sexual identity and orientation. +In the interest of fostering an open, collaborative, and welcoming environment, we as contributors and maintainers of nf-core, pledge to making participation in our projects and community a harassment-free experience for everyone, regardless of: -## Our Standards +- Age +- Body size +- Familial status +- Gender identity and expression +- Geographical location +- Level of experience +- Nationality and national origins +- Native language +- Physical and neurological ability +- Race or ethnicity +- Religion +- Sexual identity and orientation +- Socioeconomic status -Examples of behavior that contributes to creating a positive environment include: +Please note that the list above is alphabetised and is therefore not ranked in any order of preference or importance. -* Using welcoming and inclusive language -* Being respectful of differing viewpoints and experiences -* Gracefully accepting constructive criticism -* Focusing on what is best for the community -* Showing empathy towards other community members +## Preamble -Examples of unacceptable behavior by participants include: +> Note: This Code of Conduct (CoC) has been drafted by the nf-core Safety Officer and been edited after input from members of the nf-core team and others. "We", in this document, refers to the Safety Officer and members of the nf-core core team, both of whom are deemed to be members of the nf-core community and are therefore required to abide by this Code of Conduct. This document will amended periodically to keep it up-to-date, and in case of any dispute, the most current version will apply. -* The use of sexualized language or imagery and unwelcome sexual attention or advances -* Trolling, insulting/derogatory comments, and personal or political attacks -* Public or private harassment -* Publishing others' private information, such as a physical or electronic address, without explicit permission -* Other conduct which could reasonably be considered inappropriate in a professional setting +An up-to-date list of members of the nf-core core team can be found [here](https://nf-co.re/about). Our current safety officer is Renuka Kudva. + +nf-core is a young and growing community that welcomes contributions from anyone with a shared vision for [Open Science Policies](https://www.fosteropenscience.eu/taxonomy/term/8). Open science policies encompass inclusive behaviours and we strive to build and maintain a safe and inclusive environment for all individuals. + +We have therefore adopted this code of conduct (CoC), which we require all members of our community and attendees in nf-core events to adhere to in all our workspaces at all times. Workspaces include but are not limited to Slack, meetings on Zoom, Jitsi, YouTube live etc. + +Our CoC will be strictly enforced and the nf-core team reserve the right to exclude participants who do not comply with our guidelines from our workspaces and future nf-core activities. + +We ask all members of our community to help maintain a supportive and productive workspace and to avoid behaviours that can make individuals feel unsafe or unwelcome. Please help us maintain and uphold this CoC. + +Questions, concerns or ideas on what we can include? Contact safety [at] nf-co [dot] re ## Our Responsibilities -Project maintainers are responsible for clarifying the standards of acceptable behavior and are expected to take appropriate and fair corrective action in response to any instances of unacceptable behavior. +The safety officer is responsible for clarifying the standards of acceptable behavior and are expected to take appropriate and fair corrective action in response to any instances of unacceptable behaviour. + +The safety officer in consultation with the nf-core core team have the right and responsibility to remove, edit, or reject comments, commits, code, wiki edits, issues, and other contributions that are not aligned to this Code of Conduct, or to ban temporarily or permanently any contributor for other behaviors that they deem inappropriate, threatening, offensive, or harmful. + +Members of the core team or the safety officer who violate the CoC will be required to recuse themselves pending investigation. They will not have access to any reports of the violations and be subject to the same actions as others in violation of the CoC. + +## When are where does this Code of Conduct apply? + +Participation in the nf-core community is contingent on following these guidelines in all our workspaces and events. This includes but is not limited to the following listed alphabetically and therefore in no order of preference: + +- Communicating with an official project email address. +- Communicating with community members within the nf-core Slack channel. +- Participating in hackathons organised by nf-core (both online and in-person events). +- Participating in collaborative work on GitHub, Google Suite, community calls, mentorship meetings, email correspondence. +- Participating in workshops, training, and seminar series organised by nf-core (both online and in-person events). This applies to events hosted on web-based platforms such as Zoom, Jitsi, YouTube live etc. +- Representing nf-core on social media. This includes both official and personal accounts. + +## nf-core cares 😊 + +nf-core's CoC and expectations of respectful behaviours for all participants (including organisers and the nf-core team) include but are not limited to the following (listed in alphabetical order): + +- Ask for consent before sharing another community member’s personal information (including photographs) on social media. +- Be respectful of differing viewpoints and experiences. We are all here to learn from one another and a difference in opinion can present a good learning opportunity. +- Celebrate your accomplishments at events! (Get creative with your use of emojis 🎉 🥳 💯 🙌 !) +- Demonstrate empathy towards other community members. (We don’t all have the same amount of time to dedicate to nf-core. If tasks are pending, don’t hesitate to gently remind members of your team. If you are leading a task, ask for help if you feel overwhelmed.) +- Engage with and enquire after others. (This is especially important given the geographically remote nature of the nf-core community, so let’s do this the best we can) +- Focus on what is best for the team and the community. (When in doubt, ask) +- Graciously accept constructive criticism, yet be unafraid to question, deliberate, and learn. +- Introduce yourself to members of the community. (We’ve all been outsiders and we know that talking to strangers can be hard for some, but remember we’re interested in getting to know you and your visions for open science!) +- Show appreciation and **provide clear feedback**. (This is especially important because we don’t see each other in person and it can be harder to interpret subtleties. Also remember that not everyone understands a certain language to the same extent as you do, so **be clear in your communications to be kind.**) +- Take breaks when you feel like you need them. +- Using welcoming and inclusive language. (Participants are encouraged to display their chosen pronouns on Zoom or in communication on Slack.) + +## nf-core frowns on 😕 + +The following behaviours from any participants within the nf-core community (including the organisers) will be considered unacceptable under this code of conduct. Engaging or advocating for any of the following could result in expulsion from nf-core workspaces. + +- Deliberate intimidation, stalking or following and sustained disruption of communication among participants of the community. This includes hijacking shared screens through actions such as using the annotate tool in conferencing software such as Zoom. +- “Doxing” i.e. posting (or threatening to post) another person’s personal identifying information online. +- Spamming or trolling of individuals on social media. +- Use of sexual or discriminatory imagery, comments, or jokes and unwelcome sexual attention. +- Verbal and text comments that reinforce social structures of domination related to gender, gender identity and expression, sexual orientation, ability, physical appearance, body size, race, age, religion or work experience. + +### Online Trolling + +The majority of nf-core interactions and events are held online. Unfortunately, holding events online comes with the added issue of online trolling. This is unacceptable, reports of such behaviour will be taken very seriously, and perpetrators will be excluded from activities immediately. + +All community members are required to ask members of the group they are working within for explicit consent prior to taking screenshots of individuals during video calls. + +## Procedures for Reporting CoC violations -Project maintainers have the right and responsibility to remove, edit, or reject comments, commits, code, wiki edits, issues, and other contributions that are not aligned to this Code of Conduct, or to ban temporarily or permanently any contributor for other behaviors that they deem inappropriate, threatening, offensive, or harmful. +If someone makes you feel uncomfortable through their behaviours or actions, report it as soon as possible. -## Scope +You can reach out to members of the [nf-core core team](https://nf-co.re/about) and they will forward your concerns to the safety officer(s). -This Code of Conduct applies both within project spaces and in public spaces when an individual is representing the project or its community. Examples of representing a project or community include using an official project e-mail address, posting via an official social media account, or acting as an appointed representative at an online or offline event. Representation of a project may be further defined and clarified by project maintainers. +Issues directly concerning members of the core team will be dealt with by other members of the core team and the safety manager, and possible conflicts of interest will be taken into account. nf-core is also in discussions about having an ombudsperson, and details will be shared in due course. -## Enforcement +All reports will be handled with utmost discretion and confidentially. -Instances of abusive, harassing, or otherwise unacceptable behavior may be reported by contacting the project team on [Slack](https://nf-co.re/join/slack). The project team will review and investigate all complaints, and will respond in a way that it deems appropriate to the circumstances. The project team is obligated to maintain confidentiality with regard to the reporter of an incident. Further details of specific enforcement policies may be posted separately. +## Attribution and Acknowledgements -Project maintainers who do not follow or enforce the Code of Conduct in good faith may face temporary or permanent repercussions as determined by other members of the project's leadership. +- The [Contributor Covenant, version 1.4](http://contributor-covenant.org/version/1/4) +- The [OpenCon 2017 Code of Conduct](http://www.opencon2017.org/code_of_conduct) (CC BY 4.0 OpenCon organisers, SPARC and Right to Research Coalition) +- The [eLife innovation sprint 2020 Code of Conduct](https://sprint.elifesciences.org/code-of-conduct/) +- The [Mozilla Community Participation Guidelines v3.1](https://www.mozilla.org/en-US/about/governance/policies/participation/) (version 3.1, CC BY-SA 3.0 Mozilla) -## Attribution +## Changelog -This Code of Conduct is adapted from the [Contributor Covenant][homepage], version 1.4, available at [https://www.contributor-covenant.org/version/1/4/code-of-conduct/][version] +### v1.0 - March 12th, 2021 -[homepage]: https://contributor-covenant.org -[version]: https://www.contributor-covenant.org/version/1/4/code-of-conduct/ +- Complete rewrite from original [Contributor Covenant](http://contributor-covenant.org/) CoC. diff --git a/Dockerfile b/Dockerfile index 0c5ae5e88..4ade659e6 100644 --- a/Dockerfile +++ b/Dockerfile @@ -1,4 +1,4 @@ -FROM nfcore/base:1.12.1 +FROM nfcore/base:1.13 LABEL authors="Philip Ewels" \ description="Docker image containing all software requirements for the nf-core/chipseq pipeline" @@ -11,7 +11,3 @@ ENV PATH /opt/conda/envs/nf-core-chipseq-1.3.0dev/bin:$PATH # Dump the details of the installed packages to a file for posterity RUN conda env export --name nf-core-chipseq-1.3.0dev > nf-core-chipseq-1.3.0dev.yml - -# Instruct R processes to use these empty files instead of clashing with a local version -RUN touch .Rprofile -RUN touch .Renviron diff --git a/README.md b/README.md index b368f5d77..9be9fefca 100644 --- a/README.md +++ b/README.md @@ -21,12 +21,12 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool 1. Install [`nextflow`](https://nf-co.re/usage/installation) -2. Install any of [`Docker`](https://docs.docker.com/engine/installation/), [`Singularity`](https://www.sylabs.io/guides/3.0/user-guide/) or [`Podman`](https://podman.io/) for full pipeline reproducibility _(please only use [`Conda`](https://conda.io/miniconda.html) as a last resort; see [docs](https://nf-co.re/usage/configuration#basic-configuration-profiles))_ +2. Install any of [`Docker`](https://docs.docker.com/engine/installation/), [`Singularity`](https://www.sylabs.io/guides/3.0/user-guide/), [`Podman`](https://podman.io/), [`Shifter`](https://nersc.gitlab.io/development/shifter/how-to-use/) or [`Charliecloud`](https://hpc.github.io/charliecloud/) for full pipeline reproducibility _(please only use [`Conda`](https://conda.io/miniconda.html) as a last resort; see [docs](https://nf-co.re/usage/configuration#basic-configuration-profiles))_ 3. Download the pipeline and test it on a minimal dataset with a single command: ```bash - nextflow run nf-core/chipseq -profile test, + nextflow run nf-core/chipseq -profile test, ``` > Please check [nf-core/configs](https://github.com/nf-core/configs#documentation) to see if a custom config file to run nf-core pipelines already exists for your Institute. If so, you can simply use `-profile ` in your command. This will enable either `docker` or `singularity` and set the appropriate execution settings for your local compute environment. @@ -36,7 +36,7 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool ```bash - nextflow run nf-core/chipseq -profile --input '*_R{1,2}.fastq.gz' --genome GRCh37 + nextflow run nf-core/chipseq -profile --input '*_R{1,2}.fastq.gz' --genome GRCh37 ``` See [usage docs](https://nf-co.re/chipseq/usage) for all of the available options when running the pipeline. @@ -83,7 +83,6 @@ You can cite the `nf-core` publication as follows: > Philip Ewels, Alexander Peltzer, Sven Fillinger, Harshil Patel, Johannes Alneberg, Andreas Wilm, Maxime Ulysse Garcia, Paolo Di Tommaso & Sven Nahnsen. > > _Nat Biotechnol._ 2020 Feb 13. doi: [10.1038/s41587-020-0439-x](https://dx.doi.org/10.1038/s41587-020-0439-x). -> ReadCube: [Full Access Link](https://rdcu.be/b1GjZ) In addition, references of tools and data used in this pipeline are as follows: diff --git 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automatically from the pipeline schema and can no longer be found in markdown files._ - ## Introduction This document describes the output produced by the pipeline. Most of the plots are taken from the MultiQC report, which summarises results at the end of the pipeline. diff --git a/docs/usage.md b/docs/usage.md index 5bb81b07a..1040afb1f 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -51,7 +51,7 @@ This version number will be logged in reports when you run the pipeline, so that Use this parameter to choose a configuration profile. Profiles can give configuration presets for different compute environments. -Several generic profiles are bundled with the pipeline which instruct the pipeline to use software packaged using different methods (Docker, Singularity, Podman, Conda) - see below. +Several generic profiles are bundled with the pipeline which instruct the pipeline to use software packaged using different methods (Docker, Singularity, Podman, Shifter, Charliecloud, Conda) - see below. > We highly recommend the use of Docker or Singularity containers for full pipeline reproducibility, however when this is not possible, Conda is also supported. @@ -71,8 +71,14 @@ If `-profile` is not specified, the pipeline will run locally and expect all sof * `podman` * A generic configuration profile to be used with [Podman](https://podman.io/) * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) +* `shifter` + * A generic configuration profile to be used with [Shifter](https://nersc.gitlab.io/development/shifter/how-to-use/) + * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) +* `charliecloud` + * A generic configuration profile to be used with [Charliecloud](https://hpc.github.io/charliecloud/) + * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) * `conda` - * Please only use Conda as a last resort i.e. when it's not possible to run the pipeline with Docker, Singularity or Podman. + * Please only use Conda as a last resort i.e. when it's not possible to run the pipeline with Docker, Singularity, Podman, Shifter or Charliecloud. * A generic configuration profile to be used with [Conda](https://conda.io/docs/) * Pulls most software from [Bioconda](https://bioconda.github.io/) * `test` @@ -103,6 +109,8 @@ process { } ``` +To find the exact name of a process you wish to modify the compute resources, check the live-status of a nextflow run displayed on your terminal or check the nextflow error for a line like so: `Error executing process > 'bwa'`. In this case the name to specify in the custom config file is `bwa`. + See the main [Nextflow documentation](https://www.nextflow.io/docs/latest/config.html) for more information. If you are likely to be running `nf-core` pipelines regularly it may be a good idea to request that your custom config file is uploaded to the `nf-core/configs` git repository. Before you do this please can you test that the config file works with your pipeline of choice using the `-c` parameter (see definition above). You can then create a pull request to the `nf-core/configs` repository with the addition of your config file, associated documentation file (see examples in [`nf-core/configs/docs`](https://github.com/nf-core/configs/tree/master/docs)), and amending [`nfcore_custom.config`](https://github.com/nf-core/configs/blob/master/nfcore_custom.config) to include your custom profile. diff --git a/lib/Headers.groovy b/lib/Headers.groovy new file mode 100644 index 000000000..15d1d3880 --- /dev/null +++ b/lib/Headers.groovy @@ -0,0 +1,43 @@ +/* + * This file holds several functions used to render the nf-core ANSI header. + */ + +class Headers { + + private static Map log_colours(Boolean monochrome_logs) { + Map colorcodes = [:] + colorcodes['reset'] = monochrome_logs ? '' : "\033[0m" + colorcodes['dim'] = monochrome_logs ? '' : "\033[2m" + colorcodes['black'] = monochrome_logs ? '' : "\033[0;30m" + colorcodes['green'] = monochrome_logs ? '' : "\033[0;32m" + colorcodes['yellow'] = monochrome_logs ? '' : "\033[0;33m" + colorcodes['yellow_bold'] = monochrome_logs ? '' : "\033[1;93m" + colorcodes['blue'] = monochrome_logs ? '' : "\033[0;34m" + colorcodes['purple'] = monochrome_logs ? '' : "\033[0;35m" + colorcodes['cyan'] = monochrome_logs ? '' : "\033[0;36m" + colorcodes['white'] = monochrome_logs ? '' : "\033[0;37m" + colorcodes['red'] = monochrome_logs ? '' : "\033[1;91m" + return colorcodes + } + + static String dashed_line(monochrome_logs) { + Map colors = log_colours(monochrome_logs) + return "-${colors.dim}----------------------------------------------------${colors.reset}-" + } + + static String nf_core(workflow, monochrome_logs) { + Map colors = log_colours(monochrome_logs) + String.format( + """\n + ${dashed_line(monochrome_logs)} + ${colors.green},--.${colors.black}/${colors.green},-.${colors.reset} + ${colors.blue} ___ __ __ __ ___ ${colors.green}/,-._.--~\'${colors.reset} + ${colors.blue} |\\ | |__ __ / ` / \\ |__) |__ ${colors.yellow}} {${colors.reset} + ${colors.blue} | \\| | \\__, \\__/ | \\ |___ ${colors.green}\\`-._,-`-,${colors.reset} + ${colors.green}`._,._,\'${colors.reset} + ${colors.purple} ${workflow.manifest.name} v${workflow.manifest.version}${colors.reset} + ${dashed_line(monochrome_logs)} + """.stripIndent() + ) + } +} diff --git a/lib/NfcoreSchema.groovy b/lib/NfcoreSchema.groovy new file mode 100644 index 000000000..78e8c65d7 --- /dev/null +++ b/lib/NfcoreSchema.groovy @@ -0,0 +1,571 @@ +/* + * This file holds several functions used to perform JSON parameter validation, help and summary rendering for the nf-core pipeline template. + */ + +import org.everit.json.schema.Schema +import org.everit.json.schema.loader.SchemaLoader +import org.everit.json.schema.ValidationException +import org.json.JSONObject +import org.json.JSONTokener +import org.json.JSONArray +import groovy.json.JsonSlurper +import groovy.json.JsonBuilder + +class NfcoreSchema { + + /* + * Function to loop over all parameters defined in schema and check + * whether the given paremeters adhere to the specificiations + */ + /* groovylint-disable-next-line UnusedPrivateMethodParameter */ + private static void validateParameters(params, jsonSchema, log) { + def has_error = false + //=====================================================================// + // Check for nextflow core params and unexpected params + def json = new File(jsonSchema).text + def Map schemaParams = (Map) new JsonSlurper().parseText(json).get('definitions') + def nf_params = [ + // Options for base `nextflow` command + 'bg', + 'c', + 'C', + 'config', + 'd', + 'D', + 'dockerize', + 'h', + 'log', + 'q', + 'quiet', + 'syslog', + 'v', + 'version', + + // Options for `nextflow run` command + 'ansi', + 'ansi-log', + 'bg', + 'bucket-dir', + 'c', + 'cache', + 'config', + 'dsl2', + 'dump-channels', + 'dump-hashes', + 'E', + 'entry', + 'latest', + 'lib', + 'main-script', + 'N', + 'name', + 'offline', + 'params-file', + 'pi', + 'plugins', + 'poll-interval', + 'pool-size', + 'profile', + 'ps', + 'qs', + 'queue-size', + 'r', + 'resume', + 'revision', + 'stdin', + 'stub', + 'stub-run', + 'test', + 'w', + 'with-charliecloud', + 'with-conda', + 'with-dag', + 'with-docker', + 'with-mpi', + 'with-notification', + 'with-podman', + 'with-report', + 'with-singularity', + 'with-timeline', + 'with-tower', + 'with-trace', + 'with-weblog', + 'without-docker', + 'without-podman', + 'work-dir' + ] + def unexpectedParams = [] + + // Collect expected parameters from the schema + def expectedParams = [] + for (group in schemaParams) { + for (p in group.value['properties']) { + expectedParams.push(p.key) + } + } + + for (specifiedParam in params.keySet()) { + // nextflow params + if (nf_params.contains(specifiedParam)) { + log.error "ERROR: You used a core Nextflow option with two hyphens: '--${specifiedParam}'. Please resubmit with '-${specifiedParam}'" + has_error = true + } + // unexpected params + def params_ignore = params.schema_ignore_params.split(',') + 'schema_ignore_params' + if (!expectedParams.contains(specifiedParam) && !params_ignore.contains(specifiedParam)) { + unexpectedParams.push(specifiedParam) + } + } + + //=====================================================================// + // Validate parameters against the schema + InputStream inputStream = new File(jsonSchema).newInputStream() + JSONObject rawSchema = new JSONObject(new JSONTokener(inputStream)) + + // Remove anything that's in params.schema_ignore_params + rawSchema = removeIgnoredParams(rawSchema, params) + + Schema schema = SchemaLoader.load(rawSchema) + + // Clean the parameters + def cleanedParams = cleanParameters(params) + + // Convert to JSONObject + def jsonParams = new JsonBuilder(cleanedParams) + JSONObject paramsJSON = new JSONObject(jsonParams.toString()) + + // Validate + try { + schema.validate(paramsJSON) + } catch (ValidationException e) { + println '' + log.error 'ERROR: Validation of pipeline parameters failed!' + JSONObject exceptionJSON = e.toJSON() + printExceptions(exceptionJSON, paramsJSON, log) + println '' + has_error = true + } + + // Check for unexpected parameters + if (unexpectedParams.size() > 0) { + Map colors = log_colours(params.monochrome_logs) + println '' + def warn_msg = 'Found unexpected parameters:' + for (unexpectedParam in unexpectedParams) { + warn_msg = warn_msg + "\n* --${unexpectedParam}: ${params[unexpectedParam].toString()}" + } + log.warn warn_msg + log.info "- ${colors.dim}Ignore this warning: params.schema_ignore_params = \"${unexpectedParams.join(',')}\" ${colors.reset}" + println '' + } + + if (has_error) { + System.exit(1) + } + } + + // Loop over nested exceptions and print the causingException + private static void printExceptions(exJSON, paramsJSON, log) { + def causingExceptions = exJSON['causingExceptions'] + if (causingExceptions.length() == 0) { + def m = exJSON['message'] =~ /required key \[([^\]]+)\] not found/ + // Missing required param + if (m.matches()) { + log.error "* Missing required parameter: --${m[0][1]}" + } + // Other base-level error + else if (exJSON['pointerToViolation'] == '#') { + log.error "* ${exJSON['message']}" + } + // Error with specific param + else { + def param = exJSON['pointerToViolation'] - ~/^#\// + def param_val = paramsJSON[param].toString() + log.error "* --${param}: ${exJSON['message']} (${param_val})" + } + } + for (ex in causingExceptions) { + printExceptions(ex, paramsJSON, log) + } + } + + // Remove an element from a JSONArray + private static JSONArray removeElement(jsonArray, element){ + def list = [] + int len = jsonArray.length() + for (int i=0;i + if(rawSchema.keySet().contains('definitions')){ + rawSchema.definitions.each { definition -> + for (key in definition.keySet()){ + if (definition[key].get("properties").keySet().contains(ignore_param)){ + // Remove the param to ignore + definition[key].get("properties").remove(ignore_param) + // If the param was required, change this + if (definition[key].has("required")) { + def cleaned_required = removeElement(definition[key].required, ignore_param) + definition[key].put("required", cleaned_required) + } + } + } + } + } + if(rawSchema.keySet().contains('properties') && rawSchema.get('properties').containsKey(ignore_param)) { + rawSchema.get("properties").remove(ignore_param) + } + if(rawSchema.keySet().contains('required') && rawSchema.required.contains(ignore_param)) { + def cleaned_required = removeElement(rawSchema.required, ignore_param) + rawSchema.put("required", cleaned_required) + } + } + return rawSchema + } + + private static Map cleanParameters(params) { + def new_params = params.getClass().newInstance(params) + for (p in params) { + // remove anything evaluating to false + if (!p['value']) { + new_params.remove(p.key) + } + // Cast MemoryUnit to String + if (p['value'].getClass() == nextflow.util.MemoryUnit) { + new_params.replace(p.key, p['value'].toString()) + } + // Cast Duration to String + if (p['value'].getClass() == nextflow.util.Duration) { + new_params.replace(p.key, p['value'].toString()) + } + // Cast LinkedHashMap to String + if (p['value'].getClass() == LinkedHashMap) { + new_params.replace(p.key, p['value'].toString()) + } + } + return new_params + } + + /* + * This method tries to read a JSON params file + */ + private static LinkedHashMap params_load(String json_schema) { + def params_map = new LinkedHashMap() + try { + params_map = params_read(json_schema) + } catch (Exception e) { + println "Could not read parameters settings from JSON. $e" + params_map = new LinkedHashMap() + } + return params_map + } + + private static Map log_colours(Boolean monochrome_logs) { + Map colorcodes = [:] + + // Reset / Meta + colorcodes['reset'] = monochrome_logs ? '' : "\033[0m" + colorcodes['bold'] = monochrome_logs ? '' : "\033[1m" + colorcodes['dim'] = monochrome_logs ? '' : "\033[2m" + colorcodes['underlined'] = monochrome_logs ? '' : "\033[4m" + colorcodes['blink'] = monochrome_logs ? '' : "\033[5m" + colorcodes['reverse'] = monochrome_logs ? '' : "\033[7m" + colorcodes['hidden'] = monochrome_logs ? '' : "\033[8m" + + // Regular Colors + colorcodes['black'] = monochrome_logs ? '' : "\033[0;30m" + colorcodes['red'] = monochrome_logs ? '' : "\033[0;31m" + colorcodes['green'] = monochrome_logs ? '' : "\033[0;32m" + colorcodes['yellow'] = monochrome_logs ? '' : "\033[0;33m" + colorcodes['blue'] = monochrome_logs ? '' : "\033[0;34m" + colorcodes['purple'] = monochrome_logs ? '' : "\033[0;35m" + colorcodes['cyan'] = monochrome_logs ? '' : "\033[0;36m" + colorcodes['white'] = monochrome_logs ? '' : "\033[0;37m" + + // Bold + colorcodes['bblack'] = monochrome_logs ? '' : "\033[1;30m" + colorcodes['bred'] = monochrome_logs ? '' : "\033[1;31m" + colorcodes['bgreen'] = monochrome_logs ? '' : "\033[1;32m" + colorcodes['byellow'] = monochrome_logs ? '' : "\033[1;33m" + colorcodes['bblue'] = monochrome_logs ? '' : "\033[1;34m" + colorcodes['bpurple'] = monochrome_logs ? '' : "\033[1;35m" + colorcodes['bcyan'] = monochrome_logs ? '' : "\033[1;36m" + colorcodes['bwhite'] = monochrome_logs ? '' : "\033[1;37m" + + // Underline + colorcodes['ublack'] = monochrome_logs ? '' : "\033[4;30m" + colorcodes['ured'] = monochrome_logs ? '' : "\033[4;31m" + colorcodes['ugreen'] = monochrome_logs ? '' : "\033[4;32m" + colorcodes['uyellow'] = monochrome_logs ? '' : "\033[4;33m" + colorcodes['ublue'] = monochrome_logs ? '' : "\033[4;34m" + colorcodes['upurple'] = monochrome_logs ? '' : "\033[4;35m" + colorcodes['ucyan'] = monochrome_logs ? '' : "\033[4;36m" + colorcodes['uwhite'] = monochrome_logs ? '' : "\033[4;37m" + + // High Intensity + colorcodes['iblack'] = monochrome_logs ? '' : "\033[0;90m" + colorcodes['ired'] = monochrome_logs ? '' : "\033[0;91m" + colorcodes['igreen'] = monochrome_logs ? '' : "\033[0;92m" + colorcodes['iyellow'] = monochrome_logs ? '' : "\033[0;93m" + colorcodes['iblue'] = monochrome_logs ? '' : "\033[0;94m" + colorcodes['ipurple'] = monochrome_logs ? '' : "\033[0;95m" + colorcodes['icyan'] = monochrome_logs ? '' : "\033[0;96m" + colorcodes['iwhite'] = monochrome_logs ? '' : "\033[0;97m" + + // Bold High Intensity + colorcodes['biblack'] = monochrome_logs ? '' : "\033[1;90m" + colorcodes['bired'] = monochrome_logs ? '' : "\033[1;91m" + colorcodes['bigreen'] = monochrome_logs ? '' : "\033[1;92m" + colorcodes['biyellow'] = monochrome_logs ? '' : "\033[1;93m" + colorcodes['biblue'] = monochrome_logs ? '' : "\033[1;94m" + colorcodes['bipurple'] = monochrome_logs ? '' : "\033[1;95m" + colorcodes['bicyan'] = monochrome_logs ? '' : "\033[1;96m" + colorcodes['biwhite'] = monochrome_logs ? '' : "\033[1;97m" + + return colorcodes + } + + static String dashed_line(monochrome_logs) { + Map colors = log_colours(monochrome_logs) + return "-${colors.dim}----------------------------------------------------${colors.reset}-" + } + + /* + Method to actually read in JSON file using Groovy. + Group (as Key), values are all parameters + - Parameter1 as Key, Description as Value + - Parameter2 as Key, Description as Value + .... + Group + - + */ + private static LinkedHashMap params_read(String json_schema) throws Exception { + def json = new File(json_schema).text + def Map schema_definitions = (Map) new JsonSlurper().parseText(json).get('definitions') + def Map schema_properties = (Map) new JsonSlurper().parseText(json).get('properties') + /* Tree looks like this in nf-core schema + * definitions <- this is what the first get('definitions') gets us + group 1 + title + description + properties + parameter 1 + type + description + parameter 2 + type + description + group 2 + title + description + properties + parameter 1 + type + description + * properties <- parameters can also be ungrouped, outside of definitions + parameter 1 + type + description + */ + + // Grouped params + def params_map = new LinkedHashMap() + schema_definitions.each { key, val -> + def Map group = schema_definitions."$key".properties // Gets the property object of the group + def title = schema_definitions."$key".title + def sub_params = new LinkedHashMap() + group.each { innerkey, value -> + sub_params.put(innerkey, value) + } + params_map.put(title, sub_params) + } + + // Ungrouped params + def ungrouped_params = new LinkedHashMap() + schema_properties.each { innerkey, value -> + ungrouped_params.put(innerkey, value) + } + params_map.put("Other parameters", ungrouped_params) + + return params_map + } + + /* + * Get maximum number of characters across all parameter names + */ + private static Integer params_max_chars(params_map) { + Integer max_chars = 0 + for (group in params_map.keySet()) { + def group_params = params_map.get(group) // This gets the parameters of that particular group + for (param in group_params.keySet()) { + if (param.size() > max_chars) { + max_chars = param.size() + } + } + } + return max_chars + } + + /* + * Beautify parameters for --help + */ + private static String params_help(workflow, params, json_schema, command) { + Map colors = log_colours(params.monochrome_logs) + Integer num_hidden = 0 + String output = '' + output += 'Typical pipeline command:\n\n' + output += " ${colors.cyan}${command}${colors.reset}\n\n" + Map params_map = params_load(json_schema) + Integer max_chars = params_max_chars(params_map) + 1 + Integer desc_indent = max_chars + 14 + Integer dec_linewidth = 160 - desc_indent + for (group in params_map.keySet()) { + Integer num_params = 0 + String group_output = colors.underlined + colors.bold + group + colors.reset + '\n' + def group_params = params_map.get(group) // This gets the parameters of that particular group + for (param in group_params.keySet()) { + if (group_params.get(param).hidden && !params.show_hidden_params) { + num_hidden += 1 + continue; + } + def type = '[' + group_params.get(param).type + ']' + def description = group_params.get(param).description + def defaultValue = group_params.get(param).default ? " [default: " + group_params.get(param).default.toString() + "]" : '' + def description_default = description + colors.dim + defaultValue + colors.reset + // Wrap long description texts + // Loosely based on https://dzone.com/articles/groovy-plain-text-word-wrap + if (description_default.length() > dec_linewidth){ + List olines = [] + String oline = "" // " " * indent + description_default.split(" ").each() { wrd -> + if ((oline.size() + wrd.size()) <= dec_linewidth) { + oline += wrd + " " + } else { + olines += oline + oline = wrd + " " + } + } + olines += oline + description_default = olines.join("\n" + " " * desc_indent) + } + group_output += " --" + param.padRight(max_chars) + colors.dim + type.padRight(10) + colors.reset + description_default + '\n' + num_params += 1 + } + group_output += '\n' + if (num_params > 0){ + output += group_output + } + } + output += dashed_line(params.monochrome_logs) + if (num_hidden > 0){ + output += colors.dim + "\n Hiding $num_hidden params, use --show_hidden_params to show.\n" + colors.reset + output += dashed_line(params.monochrome_logs) + } + return output + } + + /* + * Groovy Map summarising parameters/workflow options used by the pipeline + */ + private static LinkedHashMap params_summary_map(workflow, params, json_schema) { + // Get a selection of core Nextflow workflow options + def Map workflow_summary = [:] + if (workflow.revision) { + workflow_summary['revision'] = workflow.revision + } + workflow_summary['runName'] = workflow.runName + if (workflow.containerEngine) { + workflow_summary['containerEngine'] = "$workflow.containerEngine" + } + if (workflow.container) { + workflow_summary['container'] = "$workflow.container" + } + workflow_summary['launchDir'] = workflow.launchDir + workflow_summary['workDir'] = workflow.workDir + workflow_summary['projectDir'] = workflow.projectDir + workflow_summary['userName'] = workflow.userName + workflow_summary['profile'] = workflow.profile + workflow_summary['configFiles'] = workflow.configFiles.join(', ') + + // Get pipeline parameters defined in JSON Schema + def Map params_summary = [:] + def blacklist = ['hostnames'] + def params_map = params_load(json_schema) + for (group in params_map.keySet()) { + def sub_params = new LinkedHashMap() + def group_params = params_map.get(group) // This gets the parameters of that particular group + for (param in group_params.keySet()) { + if (params.containsKey(param) && !blacklist.contains(param)) { + def params_value = params.get(param) + def schema_value = group_params.get(param).default + def param_type = group_params.get(param).type + if (schema_value == null) { + if (param_type == 'boolean') { + schema_value = false + } + if (param_type == 'string') { + schema_value = '' + } + if (param_type == 'integer') { + schema_value = 0 + } + } else { + if (param_type == 'string') { + if (schema_value.contains('$projectDir') || schema_value.contains('${projectDir}')) { + def sub_string = schema_value.replace('\$projectDir', '') + sub_string = sub_string.replace('\${projectDir}', '') + if (params_value.contains(sub_string)) { + schema_value = params_value + } + } + if (schema_value.contains('$params.outdir') || schema_value.contains('${params.outdir}')) { + def sub_string = schema_value.replace('\$params.outdir', '') + sub_string = sub_string.replace('\${params.outdir}', '') + if ("${params.outdir}${sub_string}" == params_value) { + schema_value = params_value + } + } + } + } + + if (params_value != schema_value) { + sub_params.put("$param", params_value) + } + } + } + params_summary.put(group, sub_params) + } + return [ 'Core Nextflow options' : workflow_summary ] << params_summary + } + + /* + * Beautify parameters for summary and return as string + */ + private static String params_summary_log(workflow, params, json_schema) { + String output = '' + def params_map = params_summary_map(workflow, params, json_schema) + def max_chars = params_max_chars(params_map) + for (group in params_map.keySet()) { + def group_params = params_map.get(group) // This gets the parameters of that particular group + if (group_params) { + output += group + '\n' + for (param in group_params.keySet()) { + output += " \u001B[1m" + param.padRight(max_chars) + ": \u001B[1m" + group_params.get(param) + '\n' + } + output += '\n' + } + } + output += "[Only displaying parameters that differ from pipeline default]\n" + output += dashed_line(params.monochrome_logs) + output += '\n\n' + dashed_line(params.monochrome_logs) + return output + } + +} diff --git a/lib/nfcore_external_java_deps.jar b/lib/nfcore_external_java_deps.jar new file mode 100644 index 0000000000000000000000000000000000000000..805c8bb5e4fd43a12a5891eea5a68788309629b0 GIT binary patch literal 2291171 zcma%i1CS<7mu}m(-Ea4_?dhK8v~AnAZQHhO+qP}n-E-&Lf8*Yb{bM(7MpZ;s){{|L znGpxiIY(9k6buar3JMCSNkdW|=)W{*ATS^)VMTsgF=-L{?{Od?P#{?eNT`1hApZ%I z{U0Zz{YCuW$x{5%Vj{u{igZ#U4^op8k`lCZbMO+hRMV3)4e|_&%)3YSbmCGpVp4NX 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command for running the pipeline is as follows: - - nextflow run nf-core/chipseq --input '*_R{1,2}.fastq.gz' -profile docker - - Mandatory arguments: - --input [file] Path to input data (must be surrounded with quotes) - -profile [str] Configuration profile to use. Can use multiple (comma separated) - Available: conda, docker, singularity, test, awsbatch, and more - - Options: - --genome [str] Name of iGenomes reference - --single_end [bool] Specifies that the input is single-end reads - - References If not specified in the configuration file or you wish to overwrite any of the references - --fasta [file] Path to fasta reference - - Other options: - --outdir [file] The output directory where the results will be saved - --publish_dir_mode [str] Mode for publishing results in the output directory. Available: symlink, rellink, link, copy, copyNoFollow, move (Default: copy) - --email [email] Set this parameter to your e-mail address to get a summary e-mail with details of the run sent to you when the workflow exits - --email_on_fail [email] Same as --email, except only send mail if the workflow is not successful - --max_multiqc_email_size [str] Threshold size for MultiQC report to be attached in notification email. If file generated by pipeline exceeds the threshold, it will not be attached (Default: 25MB) - -name [str] Name for the pipeline run. If not specified, Nextflow will automatically generate a random mnemonic - - AWSBatch options: - --awsqueue [str] The AWSBatch JobQueue that needs to be set when running on AWSBatch - --awsregion [str] The AWS Region for your AWS Batch job to run on - --awscli [str] Path to the AWS CLI tool - """.stripIndent() -} +log.info Headers.nf_core(workflow, params.monochrome_logs) -// Show help message +//////////////////////////////////////////////////// +/* -- PRINT HELP -- */ +////////////////////////////////////////////////////+ +def json_schema = "$projectDir/nextflow_schema.json" if (params.help) { - helpMessage() + def command = "nextflow run nf-core/chipseq --input '*_R{1,2}.fastq.gz' -profile docker" + log.info NfcoreSchema.params_help(workflow, params, json_schema, command) exit 0 } -/* - * SET UP CONFIGURATION VARIABLES - */ +//////////////////////////////////////////////////// +/* -- VALIDATE PARAMETERS -- */ +////////////////////////////////////////////////////+ +if (params.validate_params) { + NfcoreSchema.validateParameters(params, json_schema, log) +} + +//////////////////////////////////////////////////// +/* -- Collect configuration parameters -- */ +//////////////////////////////////////////////////// // Check if genome exists in the config file if (params.genomes && params.genome && !params.genomes.containsKey(params.genome)) { - exit 1, "The provided genome '${params.genome}' is not available in the iGenomes file. Currently the available genomes are ${params.genomes.keySet().join(", ")}" + exit 1, "The provided genome '${params.genome}' is not available in the iGenomes file. Currently the available genomes are ${params.genomes.keySet().join(', ')}" } // TODO nf-core: Add any reference files that are needed @@ -73,22 +48,15 @@ if (params.genomes && params.genome && !params.genomes.containsKey(params.genome params.fasta = params.genome ? params.genomes[ params.genome ].fasta ?: false : false if (params.fasta) { ch_fasta = file(params.fasta, checkIfExists: true) } -// Has the run name been specified by the user? -// this has the bonus effect of catching both -name and --name -custom_runName = params.name -if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { - custom_runName = workflow.runName -} - // Check AWS batch settings if (workflow.profile.contains('awsbatch')) { // AWSBatch sanity checking - if (!params.awsqueue || !params.awsregion) exit 1, "Specify correct --awsqueue and --awsregion parameters on AWSBatch!" + if (!params.awsqueue || !params.awsregion) exit 1, 'Specify correct --awsqueue and --awsregion parameters on AWSBatch!' // Check outdir paths to be S3 buckets if running on AWSBatch // related: https://github.com/nextflow-io/nextflow/issues/813 - if (!params.outdir.startsWith('s3:')) exit 1, "Outdir not on S3 - specify S3 Bucket to run on AWSBatch!" + if (!params.outdir.startsWith('s3:')) exit 1, 'Outdir not on S3 - specify S3 Bucket to run on AWSBatch!' // Prevent trace files to be stored on S3 since S3 does not support rolling files. - if (params.tracedir.startsWith('s3:')) exit 1, "Specify a local tracedir or run without trace! S3 cannot be used for tracefiles." + if (params.tracedir.startsWith('s3:')) exit 1, 'Specify a local tracedir or run without trace! S3 cannot be used for tracefiles.' } // Stage config files @@ -105,13 +73,13 @@ if (params.input_paths) { Channel .from(params.input_paths) .map { row -> [ row[0], [ file(row[1][0], checkIfExists: true) ] ] } - .ifEmpty { exit 1, "params.input_paths was empty - no input files supplied" } + .ifEmpty { exit 1, 'params.input_paths was empty - no input files supplied' } .into { ch_read_files_fastqc; ch_read_files_trimming } } else { Channel .from(params.input_paths) .map { row -> [ row[0], [ file(row[1][0], checkIfExists: true), file(row[1][1], checkIfExists: true) ] ] } - .ifEmpty { exit 1, "params.input_paths was empty - no input files supplied" } + .ifEmpty { exit 1, 'params.input_paths was empty - no input files supplied' } .into { ch_read_files_fastqc; ch_read_files_trimming } } } else { @@ -121,11 +89,15 @@ if (params.input_paths) { .into { ch_read_files_fastqc; ch_read_files_trimming } } +//////////////////////////////////////////////////// +/* -- PRINT PARAMETER SUMMARY -- */ +//////////////////////////////////////////////////// +log.info NfcoreSchema.params_summary_log(workflow, params, json_schema) + // Header log info -log.info nfcoreHeader() def summary = [:] if (workflow.revision) summary['Pipeline Release'] = workflow.revision -summary['Run Name'] = custom_runName ?: workflow.runName +summary['Run Name'] = workflow.runName // TODO nf-core: Report custom parameters here summary['Input'] = params.input summary['Fasta Ref'] = params.fasta @@ -152,8 +124,6 @@ if (params.email || params.email_on_fail) { summary['E-mail on failure'] = params.email_on_fail summary['MultiQC maxsize'] = params.max_multiqc_email_size } -log.info summary.collect { k,v -> "${k.padRight(18)}: $v" }.join("\n") -log.info "-\033[2m--------------------------------------------------\033[0m-" // Check the hostnames against configured profiles checkHostname() @@ -180,13 +150,13 @@ Channel.from(summary.collect{ [it.key, it.value] }) process get_software_versions { publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode, saveAs: { filename -> - if (filename.indexOf(".csv") > 0) filename + if (filename.indexOf('.csv') > 0) filename else null - } + } output: file 'software_versions_mqc.yaml' into ch_software_versions_yaml - file "software_versions.csv" + file 'software_versions.csv' script: // TODO nf-core: Get all tools to print their version number here @@ -207,14 +177,14 @@ process fastqc { label 'process_medium' publishDir "${params.outdir}/fastqc", mode: params.publish_dir_mode, saveAs: { filename -> - filename.indexOf(".zip") > 0 ? "zips/$filename" : "$filename" - } + filename.indexOf('.zip') > 0 ? "zips/$filename" : "$filename" + } input: set val(name), file(reads) from ch_read_files_fastqc output: - file "*_fastqc.{zip,html}" into ch_fastqc_results + file '*_fastqc.{zip,html}' into ch_fastqc_results script: """ @@ -242,8 +212,12 @@ process multiqc { file "multiqc_plots" script: - rtitle = custom_runName ? "--title \"$custom_runName\"" : '' - rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' + rtitle = '' + rfilename = '' + if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { + rtitle = "--title \"${workflow.runName}\"" + rfilename = "--filename " + workflow.runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" + } custom_config_file = params.multiqc_config ? "--config $mqc_custom_config" : '' // TODO nf-core: Specify which MultiQC modules to use with -m for a faster run time """ @@ -262,7 +236,7 @@ process output_documentation { file images from ch_output_docs_images output: - file "results_description.html" + file 'results_description.html' script: """ @@ -282,7 +256,7 @@ workflow.onComplete { } def email_fields = [:] email_fields['version'] = workflow.manifest.version - email_fields['runName'] = custom_runName ?: workflow.runName + email_fields['runName'] = workflow.runName email_fields['success'] = workflow.success email_fields['dateComplete'] = workflow.complete email_fields['duration'] = workflow.duration @@ -389,28 +363,9 @@ workflow.onComplete { } - -def nfcoreHeader() { - // Log colors ANSI codes - c_black = params.monochrome_logs ? '' : "\033[0;30m"; - c_blue = params.monochrome_logs ? '' : "\033[0;34m"; - c_cyan = params.monochrome_logs ? '' : "\033[0;36m"; - c_dim = params.monochrome_logs ? '' : "\033[2m"; - c_green = params.monochrome_logs ? '' : "\033[0;32m"; - c_purple = params.monochrome_logs ? '' : "\033[0;35m"; - c_reset = params.monochrome_logs ? '' : "\033[0m"; - c_white = params.monochrome_logs ? '' : "\033[0;37m"; - c_yellow = params.monochrome_logs ? '' : "\033[0;33m"; - - return """ -${c_dim}--------------------------------------------------${c_reset}- - ${c_green},--.${c_black}/${c_green},-.${c_reset} - ${c_blue} ___ __ __ __ ___ ${c_green}/,-._.--~\'${c_reset} - ${c_blue} |\\ | |__ __ / ` / \\ |__) |__ ${c_yellow}} {${c_reset} - ${c_blue} | \\| | \\__, \\__/ | \\ |___ ${c_green}\\`-._,-`-,${c_reset} - ${c_green}`._,._,\'${c_reset} - ${c_purple} nf-core/chipseq v${workflow.manifest.version}${c_reset} - -${c_dim}--------------------------------------------------${c_reset}- - """.stripIndent() +workflow.onError { + // Print unexpected parameters - easiest is to just rerun validation + NfcoreSchema.validateParameters(params, json_schema, log) } def checkHostname() { @@ -419,15 +374,15 @@ def checkHostname() { def c_red = params.monochrome_logs ? '' : "\033[1;91m" def c_yellow_bold = params.monochrome_logs ? '' : "\033[1;93m" if (params.hostnames) { - def hostname = "hostname".execute().text.trim() + def hostname = 'hostname'.execute().text.trim() params.hostnames.each { prof, hnames -> hnames.each { hname -> if (hostname.contains(hname) && !workflow.profile.contains(prof)) { - log.error "====================================================\n" + + log.error '====================================================\n' + " ${c_red}WARNING!${c_reset} You are running with `-profile $workflow.profile`\n" + " but your machine hostname is ${c_white}'$hostname'${c_reset}\n" + " ${c_yellow_bold}It's highly recommended that you use `-profile $prof${c_reset}`\n" + - "============================================================" + '============================================================' } } } diff --git a/nextflow.config b/nextflow.config index eee65030b..50fcf4274 100644 --- a/nextflow.config +++ b/nextflow.config @@ -11,13 +11,13 @@ params { // Workflow flags // TODO nf-core: Specify your pipeline's command line flags genome = false - input = "data/*{1,2}.fastq.gz" + input = null + input_paths = null single_end = false outdir = './results' publish_dir_mode = 'copy' // Boilerplate options - name = false multiqc_config = false email = false email_on_fail = false @@ -34,6 +34,9 @@ params { config_profile_description = false config_profile_contact = false config_profile_url = false + validate_params = true + show_hidden_params = false + schema_ignore_params = 'genomes,input_paths' // Defaults only, expecting to be overwritten max_memory = 128.GB @@ -57,10 +60,21 @@ try { } profiles { - conda { process.conda = "$projectDir/environment.yml" } + conda { + docker.enabled = false + singularity.enabled = false + podman.enabled = false + shifter.enabled = false + charliecloud = false + process.conda = "$projectDir/environment.yml" + } debug { process.beforeScript = 'echo $HOSTNAME' } docker { docker.enabled = true + singularity.enabled = false + podman.enabled = false + shifter.enabled = false + charliecloud.enabled = false // Avoid this error: // WARNING: Your kernel does not support swap limit capabilities or the cgroup is not mounted. Memory limited without swap. // Testing this in nf-core after discussion here https://github.com/nf-core/tools/pull/351 @@ -68,11 +82,33 @@ profiles { docker.runOptions = '-u \$(id -u):\$(id -g)' } singularity { + docker.enabled = false singularity.enabled = true + podman.enabled = false + shifter.enabled = false + charliecloud.enabled = false singularity.autoMounts = true } podman { + singularity.enabled = false + docker.enabled = false podman.enabled = true + shifter.enabled = false + charliecloud = false + } + shifter { + singularity.enabled = false + docker.enabled = false + podman.enabled = false + shifter.enabled = true + charliecloud.enabled = false + } + charliecloud { + singularity.enabled = false + docker.enabled = false + podman.enabled = false + shifter.enabled = false + charliecloud.enabled = true } test { includeConfig 'conf/test.config' } test_full { includeConfig 'conf/test_full.config' } diff --git a/nextflow_schema.json b/nextflow_schema.json index 8641ae9a6..64563832a 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -104,12 +104,12 @@ "move" ] }, - "name": { - "type": "string", - "description": "Workflow name.", - "fa_icon": "fas fa-fingerprint", - "hidden": true, - "help_text": "A custom name for the pipeline run. Unlike the core nextflow `-name` option with one hyphen this parameter can be reused multiple times, for example if using `-resume`. Passed through to steps such as MultiQC and used for things like report filenames and titles." + "validate_params": { + "type": "boolean", + "description": "Boolean whether to validate parameters against the schema at runtime", + "default": true, + "fa_icon": "fas fa-check-square", + "hidden": true }, "email_on_fail": { "type": "string", @@ -153,6 +153,13 @@ "default": "${params.outdir}/pipeline_info", "fa_icon": "fas fa-cogs", "hidden": true + }, + "show_hidden_params": { + "type": "boolean", + "fa_icon": "far fa-eye-slash", + "description": "Show all params when using `--help`", + "hidden": true, + "help_text": "By default, parameters set as _hidden_ in the schema are not shown on the command line when a user runs with `--help`. Specifying this option will tell the pipeline to show all parameters." } } }, @@ -176,6 +183,7 @@ "description": "Maximum amount of memory that can be requested for any single job.", "default": "128.GB", "fa_icon": "fas fa-memory", + "pattern": "^[\\d\\.]+\\s*.(K|M|G|T)?B$", "hidden": true, "help_text": "Use to set an upper-limit for the memory requirement for each process. Should be a string in the format integer-unit e.g. `--max_memory '8.GB'`" }, @@ -184,6 +192,7 @@ "description": "Maximum amount of time that can be requested for any single job.", "default": "240.h", "fa_icon": "far fa-clock", + "pattern": "^[\\d\\.]+\\.*(s|m|h|d)$", "hidden": true, "help_text": "Use to set an upper-limit for the time requirement for each process. Should be a string in the format integer-unit e.g. `--max_time '2.h'`" } @@ -218,6 +227,12 @@ "hidden": true, "fa_icon": "fas fa-users-cog" }, + "config_profile_name": { + "type": "string", + "description": "Institutional config name.", + "hidden": true, + "fa_icon": "fas fa-users-cog" + }, "config_profile_description": { "type": "string", "description": "Institutional config description.", From ed4529ecdb228d1c77ba8c35e768def7695cc343 Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Fri, 19 Mar 2021 13:07:26 +0000 Subject: [PATCH 166/538] Template update for nf-core/tools version 1.13.1 --- .github/workflows/branch.yml | 12 ++++++++++-- Dockerfile | 2 +- 2 files changed, 11 insertions(+), 3 deletions(-) diff --git a/.github/workflows/branch.yml b/.github/workflows/branch.yml index d737ff7c6..0615f2af9 100644 --- a/.github/workflows/branch.yml +++ b/.github/workflows/branch.yml @@ -23,11 +23,19 @@ jobs: uses: mshick/add-pr-comment@v1 with: message: | + ## This PR is against the `master` branch :x: + + * Do not close this PR + * Click _Edit_ and change the `base` to `dev` + * This CI test will remain failed until you push a new commit + + --- + Hi @${{ github.event.pull_request.user.login }}, - It looks like this pull-request is has been made against the ${{github.event.pull_request.base.repo.full_name }} `master` branch. + It looks like this pull-request is has been made against the [${{github.event.pull_request.head.repo.full_name }}](https://github.com/${{github.event.pull_request.head.repo.full_name }}) `master` branch. The `master` branch on nf-core repositories should always contain code from the latest release. - Because of this, PRs to `master` are only allowed if they come from the ${{github.event.pull_request.base.repo.full_name }} `dev` branch. + Because of this, PRs to `master` are only allowed if they come from the [${{github.event.pull_request.head.repo.full_name }}](https://github.com/${{github.event.pull_request.head.repo.full_name }}) `dev` branch. You do not need to close this PR, you can change the target branch to `dev` by clicking the _"Edit"_ button at the top of this page. Note that even after this, the test will continue to show as failing until you push a new commit. diff --git a/Dockerfile b/Dockerfile index 4ade659e6..b107fa319 100644 --- a/Dockerfile +++ b/Dockerfile @@ -1,4 +1,4 @@ -FROM nfcore/base:1.13 +FROM nfcore/base:1.13.1 LABEL authors="Philip Ewels" \ description="Docker image containing all software requirements for the nf-core/chipseq pipeline" From c55e19a756625fb8f643110c8b387a822c59a806 Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Tue, 23 Mar 2021 15:27:17 +0000 Subject: [PATCH 167/538] Template update for nf-core/tools version 1.13.2 --- .github/workflows/ci.yml | 2 +- .github/workflows/linting.yml | 57 ++++++++++++++++++++++++++++++++- Dockerfile | 2 +- bin/markdown_to_html.py | 0 bin/scrape_software_versions.py | 0 lib/NfcoreSchema.groovy | 2 +- 6 files changed, 59 insertions(+), 4 deletions(-) mode change 100644 => 100755 bin/markdown_to_html.py mode change 100644 => 100755 bin/scrape_software_versions.py diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index e38792283..d37db83e3 100644 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -20,7 +20,7 @@ jobs: strategy: matrix: # Nextflow versions: check pipeline minimum and current latest - nxf_ver: ['20.04.0', ''] + nxf_ver: ['20.04.0', '21.03.0-edge'] steps: - name: Check out pipeline code uses: actions/checkout@v2 diff --git a/.github/workflows/linting.yml b/.github/workflows/linting.yml index 58e281df6..fcde400ce 100644 --- a/.github/workflows/linting.yml +++ b/.github/workflows/linting.yml @@ -19,6 +19,34 @@ jobs: run: npm install -g markdownlint-cli - name: Run Markdownlint run: markdownlint ${GITHUB_WORKSPACE} -c ${GITHUB_WORKSPACE}/.github/markdownlint.yml + + # If the above check failed, post a comment on the PR explaining the failure + - name: Post PR comment + if: failure() + uses: mshick/add-pr-comment@v1 + with: + message: | + ## Markdown linting is failing + + To keep the code consistent with lots of contributors, we run automated code consistency checks. + To fix this CI test, please run: + + * Install `markdownlint-cli` + * On Mac: `brew install markdownlint-cli` + * Everything else: [Install `npm`](https://www.npmjs.com/get-npm) then [install `markdownlint-cli`](https://www.npmjs.com/package/markdownlint-cli) (`npm install -g markdownlint-cli`) + * Fix the markdown errors + * Automatically: `markdownlint . --config .github/markdownlint.yml --fix` + * Manually resolve anything left from `markdownlint . --config .github/markdownlint.yml` + + Once you push these changes the test should pass, and you can hide this comment :+1: + + We highly recommend setting up markdownlint in your code editor so that this formatting is done automatically on save. Ask about it on Slack for help! + + Thanks again for your contribution! + repo-token: ${{ secrets.GITHUB_TOKEN }} + allow-repeats: false + + YAML: runs-on: ubuntu-latest steps: @@ -29,7 +57,34 @@ jobs: - name: Install yaml-lint run: npm install -g yaml-lint - name: Run yaml-lint - run: yamllint $(find ${GITHUB_WORKSPACE} -type f -name "*.yml") + run: yamllint $(find ${GITHUB_WORKSPACE} -type f -name "*.yml" -o -name "*.yaml") + + # If the above check failed, post a comment on the PR explaining the failure + - name: Post PR comment + if: failure() + uses: mshick/add-pr-comment@v1 + with: + message: | + ## YAML linting is failing + + To keep the code consistent with lots of contributors, we run automated code consistency checks. + To fix this CI test, please run: + + * Install `yaml-lint` + * [Install `npm`](https://www.npmjs.com/get-npm) then [install `yaml-lint`](https://www.npmjs.com/package/yaml-lint) (`npm install -g yaml-lint`) + * Fix the markdown errors + * Run the test locally: `yamllint $(find . -type f -name "*.yml" -o -name "*.yaml")` + * Fix any reported errors in your YAML files + + Once you push these changes the test should pass, and you can hide this comment :+1: + + We highly recommend setting up yaml-lint in your code editor so that this formatting is done automatically on save. Ask about it on Slack for help! + + Thanks again for your contribution! + repo-token: ${{ secrets.GITHUB_TOKEN }} + allow-repeats: false + + nf-core: runs-on: ubuntu-latest steps: diff --git a/Dockerfile b/Dockerfile index b107fa319..5bbd3e687 100644 --- a/Dockerfile +++ b/Dockerfile @@ -1,4 +1,4 @@ -FROM nfcore/base:1.13.1 +FROM nfcore/base:1.13.2 LABEL authors="Philip Ewels" \ description="Docker image containing all software requirements for the nf-core/chipseq pipeline" diff --git a/bin/markdown_to_html.py b/bin/markdown_to_html.py old mode 100644 new mode 100755 diff --git a/bin/scrape_software_versions.py b/bin/scrape_software_versions.py old mode 100644 new mode 100755 diff --git a/lib/NfcoreSchema.groovy b/lib/NfcoreSchema.groovy index 78e8c65d7..54935ec81 100644 --- a/lib/NfcoreSchema.groovy +++ b/lib/NfcoreSchema.groovy @@ -219,7 +219,7 @@ class NfcoreSchema { } } } - if(rawSchema.keySet().contains('properties') && rawSchema.get('properties').containsKey(ignore_param)) { + if(rawSchema.keySet().contains('properties') && rawSchema.get('properties').keySet().contains(ignore_param)) { rawSchema.get("properties").remove(ignore_param) } if(rawSchema.keySet().contains('required') && rawSchema.required.contains(ignore_param)) { From b16d4a9e49436b2d10b68ceb3651370d4b4ebe4f Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Thu, 25 Mar 2021 18:17:25 +0000 Subject: [PATCH 168/538] Template update for nf-core/tools version 1.13.3 --- Dockerfile | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/Dockerfile b/Dockerfile index 5bbd3e687..bdf7c5b01 100644 --- a/Dockerfile +++ b/Dockerfile @@ -1,4 +1,4 @@ -FROM nfcore/base:1.13.2 +FROM nfcore/base:1.13.3 LABEL authors="Philip Ewels" \ description="Docker image containing all software requirements for the nf-core/chipseq pipeline" From 0cd4788381c90cc66dd257fd94e325aff203e69f Mon Sep 17 00:00:00 2001 From: MaxUlysse Date: Mon, 26 Apr 2021 13:53:26 +0200 Subject: [PATCH 169/538] feat: remove social preview 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zOy$s&=ky|#ow^rR_{Jq5FmQ2K&l`L}_iIzBgO!Q0;Jvckd3`(Xq-!U6{cMG&pY zbnKco)*+2f$4KNHwqk5sspZvt_f#nvDTWqz=2TRQ$)ogf5h2I+P7}adij1Oq7~ejm zrIiC;8eh5mY=i^Tv8`)ly-**!5K`J&_EZrT*D;)i<{!gQ7a^AKk85hBVF)zO!ck7} zpsnN7W8!vGf6S^F>)PC(4X%pURF^nK$<&GCU1ZLfS0^>ViNsf3HR7!=}ymA3jtVDl#gL_rsVV@_o3i z*kT&rKDaF^?^eCgpR-Ynp>t2iH=WE~eTb - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - image/svg+xml - - - - - - - ChIP-seq peak-calling, QC and differential analysis pipeline - chipseq - - - - - - - - - - - - - - - - - - - - - - - - - From 769a517e57d5e2bc7e5ac457e83d399111c45268 Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Tue, 11 May 2021 11:09:47 +0000 Subject: [PATCH 170/538] Template update for nf-core/tools version 1.14 --- .github/PULL_REQUEST_TEMPLATE.md | 7 +++-- .github/workflows/ci.yml | 5 ++- Dockerfile | 2 +- README.md | 2 +- lib/NfcoreSchema.groovy | 54 +++++++++++++++++--------------- main.nf | 4 +-- nextflow.config | 16 +++++----- nextflow_schema.json | 6 ++-- 8 files changed, 52 insertions(+), 44 deletions(-) diff --git a/.github/PULL_REQUEST_TEMPLATE.md b/.github/PULL_REQUEST_TEMPLATE.md index f1d89ef72..f782cf452 100644 --- a/.github/PULL_REQUEST_TEMPLATE.md +++ b/.github/PULL_REQUEST_TEMPLATE.md @@ -10,14 +10,15 @@ Remember that PRs should be made against the dev branch, unless you're preparing Learn more about contributing: [CONTRIBUTING.md](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) --> + ## PR checklist - [ ] This comment contains a description of changes (with reason). - [ ] If you've fixed a bug or added code that should be tested, add tests! - - [ ] If you've added a new tool - add to the software_versions process and a regex to `scrape_software_versions.py` - - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) - - [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. + - [ ] If you've added a new tool - add to the software_versions process and a regex to `scrape_software_versions.py` + - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) + - [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. - [ ] Make sure your code lints (`nf-core lint .`). - [ ] Ensure the test suite passes (`nextflow run . -profile test,docker`). - [ ] Usage Documentation in `docs/usage.md` is updated. diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index d37db83e3..6123bcbc2 100644 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -8,6 +8,9 @@ on: release: types: [published] +# Uncomment if we need an edge release of Nextflow again +# env: NXF_EDGE: 1 + jobs: test: name: Run workflow tests @@ -20,7 +23,7 @@ jobs: strategy: matrix: # Nextflow versions: check pipeline minimum and current latest - nxf_ver: ['20.04.0', '21.03.0-edge'] + nxf_ver: ['20.04.0', ''] steps: - name: Check out pipeline code uses: actions/checkout@v2 diff --git a/Dockerfile b/Dockerfile index bdf7c5b01..be6f50b2f 100644 --- a/Dockerfile +++ b/Dockerfile @@ -1,4 +1,4 @@ -FROM nfcore/base:1.13.3 +FROM nfcore/base:1.14 LABEL authors="Philip Ewels" \ description="Docker image containing all software requirements for the nf-core/chipseq pipeline" diff --git a/README.md b/README.md index 9be9fefca..1f0ee33a7 100644 --- a/README.md +++ b/README.md @@ -19,7 +19,7 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool ## Quick Start -1. Install [`nextflow`](https://nf-co.re/usage/installation) +1. Install [`nextflow`](https://nf-co.re/usage/installation) (`>=20.04.0`) 2. Install any of [`Docker`](https://docs.docker.com/engine/installation/), [`Singularity`](https://www.sylabs.io/guides/3.0/user-guide/), [`Podman`](https://podman.io/), [`Shifter`](https://nersc.gitlab.io/development/shifter/how-to-use/) or [`Charliecloud`](https://hpc.github.io/charliecloud/) for full pipeline reproducibility _(please only use [`Conda`](https://conda.io/miniconda.html) as a last resort; see [docs](https://nf-co.re/usage/configuration#basic-configuration-profiles))_ diff --git a/lib/NfcoreSchema.groovy b/lib/NfcoreSchema.groovy index 54935ec81..52ee73043 100644 --- a/lib/NfcoreSchema.groovy +++ b/lib/NfcoreSchema.groovy @@ -112,8 +112,14 @@ class NfcoreSchema { } // unexpected params def params_ignore = params.schema_ignore_params.split(',') + 'schema_ignore_params' - if (!expectedParams.contains(specifiedParam) && !params_ignore.contains(specifiedParam)) { - unexpectedParams.push(specifiedParam) + def expectedParamsLowerCase = expectedParams.collect{ it.replace("-", "").toLowerCase() } + def specifiedParamLowerCase = specifiedParam.replace("-", "").toLowerCase() + if (!expectedParams.contains(specifiedParam) && !params_ignore.contains(specifiedParam) && !expectedParamsLowerCase.contains(specifiedParamLowerCase)) { + // Temporarily remove camelCase/camel-case params #1035 + def unexpectedParamsLowerCase = unexpectedParams.collect{ it.replace("-", "").toLowerCase()} + if (!unexpectedParamsLowerCase.contains(specifiedParamLowerCase)){ + unexpectedParams.push(specifiedParam) + } } } @@ -191,11 +197,11 @@ class NfcoreSchema { // Remove an element from a JSONArray private static JSONArray removeElement(jsonArray, element){ - def list = [] + def list = [] int len = jsonArray.length() - for (int i=0;i hnames.each { hname -> if (hostname.contains(hname) && !workflow.profile.contains(prof)) { - log.error '====================================================\n' + + log.error "${c_red}====================================================${c_reset}\n" + " ${c_red}WARNING!${c_reset} You are running with `-profile $workflow.profile`\n" + " but your machine hostname is ${c_white}'$hostname'${c_reset}\n" + " ${c_yellow_bold}It's highly recommended that you use `-profile $prof${c_reset}`\n" + - '============================================================' + "${c_red}====================================================${c_reset}\n" } } } diff --git a/nextflow.config b/nextflow.config index 50fcf4274..1dd986558 100644 --- a/nextflow.config +++ b/nextflow.config @@ -25,12 +25,13 @@ params { plaintext_email = false monochrome_logs = false help = false - igenomes_base = 's3://ngi-igenomes/igenomes/' + igenomes_base = 's3://ngi-igenomes/igenomes' tracedir = "${params.outdir}/pipeline_info" igenomes_ignore = false custom_config_version = 'master' custom_config_base = "https://raw.githubusercontent.com/nf-core/configs/${params.custom_config_version}" hostnames = false + config_profile_name = null config_profile_description = false config_profile_contact = false config_profile_url = false @@ -65,7 +66,7 @@ profiles { singularity.enabled = false podman.enabled = false shifter.enabled = false - charliecloud = false + charliecloud.enabled = false process.conda = "$projectDir/environment.yml" } debug { process.beforeScript = 'echo $HOSTNAME' } @@ -94,7 +95,7 @@ profiles { docker.enabled = false podman.enabled = true shifter.enabled = false - charliecloud = false + charliecloud.enabled = false } shifter { singularity.enabled = false @@ -129,21 +130,22 @@ env { // Capture exit codes from upstream processes when piping process.shell = ['/bin/bash', '-euo', 'pipefail'] +def trace_timestamp = new java.util.Date().format( 'yyyy-MM-dd_HH-mm-ss') timeline { enabled = true - file = "${params.tracedir}/execution_timeline.html" + file = "${params.tracedir}/execution_timeline_${trace_timestamp}.html" } report { enabled = true - file = "${params.tracedir}/execution_report.html" + file = "${params.tracedir}/execution_report_${trace_timestamp}.html" } trace { enabled = true - file = "${params.tracedir}/execution_trace.txt" + file = "${params.tracedir}/execution_trace_${trace_timestamp}.txt" } dag { enabled = true - file = "${params.tracedir}/pipeline_dag.svg" + file = "${params.tracedir}/pipeline_dag_${trace_timestamp}.svg" } manifest { diff --git a/nextflow_schema.json b/nextflow_schema.json index 64563832a..278dfb9eb 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -62,7 +62,7 @@ "igenomes_base": { "type": "string", "description": "Directory / URL base for iGenomes references.", - "default": "s3://ngi-igenomes/igenomes/", + "default": "s3://ngi-igenomes/igenomes", "fa_icon": "fas fa-cloud-download-alt", "hidden": true }, @@ -183,7 +183,7 @@ "description": "Maximum amount of memory that can be requested for any single job.", "default": "128.GB", "fa_icon": "fas fa-memory", - "pattern": "^[\\d\\.]+\\s*.(K|M|G|T)?B$", + "pattern": "^\\d+(\\.\\d+)?\\.?\\s*(K|M|G|T)?B$", "hidden": true, "help_text": "Use to set an upper-limit for the memory requirement for each process. Should be a string in the format integer-unit e.g. `--max_memory '8.GB'`" }, @@ -192,7 +192,7 @@ "description": "Maximum amount of time that can be requested for any single job.", "default": "240.h", "fa_icon": "far fa-clock", - "pattern": "^[\\d\\.]+\\.*(s|m|h|d)$", + "pattern": "^(\\d+\\.?\\s*(s|m|h|day)\\s*)+$", "hidden": true, "help_text": "Use to set an upper-limit for the time requirement for each process. Should be a string in the format integer-unit e.g. `--max_time '2.h'`" } From e201a4e56d60f6486f441f8389b02a6992fe0d85 Mon Sep 17 00:00:00 2001 From: kevinmenden Date: Tue, 13 Jul 2021 10:39:12 +0200 Subject: [PATCH 171/538] Template update for nf-core/tools version 2.0 --- .editorconfig | 24 + .github/CONTRIBUTING.md | 2 +- .github/ISSUE_TEMPLATE/bug_report.md | 5 +- .github/PULL_REQUEST_TEMPLATE.md | 3 +- .github/workflows/awsfulltest.yml | 52 +- .github/workflows/awstest.yml | 50 +- .github/workflows/ci.yml | 19 +- .github/workflows/linting.yml | 21 +- .github/workflows/push_dockerhub_dev.yml | 28 - .github/workflows/push_dockerhub_release.yml | 29 - .gitignore | 1 - .github/markdownlint.yml => .markdownlint.yml | 2 + CITATIONS.md | 32 + Dockerfile | 13 - README.md | 71 +- assets/samplesheet.csv | 3 + assets/schema_input.json | 39 + assets/sendmail_template.txt | 36 +- bin/check_samplesheet.py | 146 +++ bin/markdown_to_html.py | 91 -- bin/scrape_software_versions.py | 44 +- conf/base.config | 94 +- conf/igenomes.config | 843 +++++++++--------- conf/modules.config | 32 + conf/test.config | 47 +- conf/test_full.config | 38 +- docs/README.md | 4 +- docs/images/mqc_fastqc_adapter.png | Bin 0 -> 23458 bytes docs/images/mqc_fastqc_counts.png | Bin 0 -> 33918 bytes docs/images/mqc_fastqc_quality.png | Bin 0 -> 55769 bytes docs/output.md | 63 +- docs/usage.md | 214 ++++- environment.yml | 15 - lib/Headers.groovy | 43 - lib/NfcoreSchema.groovy | 528 +++++------ lib/NfcoreTemplate.groovy | 266 ++++++ lib/Utils.groovy | 47 + lib/WorkflowChipseq.groovy | 59 ++ lib/WorkflowMain.groovy | 94 ++ main.nf | 405 +-------- modules.json | 14 + modules/local/functions.nf | 68 ++ modules/local/get_software_versions.nf | 33 + modules/local/samplesheet_check.nf | 31 + modules/nf-core/modules/fastqc/functions.nf | 68 ++ modules/nf-core/modules/fastqc/main.nf | 47 + modules/nf-core/modules/fastqc/meta.yml | 51 ++ modules/nf-core/modules/multiqc/functions.nf | 68 ++ modules/nf-core/modules/multiqc/main.nf | 35 + modules/nf-core/modules/multiqc/meta.yml | 39 + nextflow.config | 300 ++++--- nextflow_schema.json | 255 +++--- subworkflows/local/input_check.nf | 42 + workflows/chipseq.nf | 141 +++ 54 files changed, 2811 insertions(+), 1884 deletions(-) create mode 100644 .editorconfig delete mode 100644 .github/workflows/push_dockerhub_dev.yml delete mode 100644 .github/workflows/push_dockerhub_release.yml rename .github/markdownlint.yml => .markdownlint.yml (90%) create mode 100644 CITATIONS.md delete mode 100644 Dockerfile create mode 100644 assets/samplesheet.csv create mode 100644 assets/schema_input.json create mode 100755 bin/check_samplesheet.py delete mode 100755 bin/markdown_to_html.py create mode 100644 conf/modules.config create mode 100755 docs/images/mqc_fastqc_adapter.png create mode 100755 docs/images/mqc_fastqc_counts.png create mode 100755 docs/images/mqc_fastqc_quality.png delete mode 100644 environment.yml delete mode 100644 lib/Headers.groovy mode change 100644 => 100755 lib/NfcoreSchema.groovy create mode 100755 lib/NfcoreTemplate.groovy create mode 100755 lib/Utils.groovy create mode 100755 lib/WorkflowChipseq.groovy create mode 100755 lib/WorkflowMain.groovy create mode 100644 modules.json create mode 100644 modules/local/functions.nf create mode 100644 modules/local/get_software_versions.nf create mode 100644 modules/local/samplesheet_check.nf create mode 100644 modules/nf-core/modules/fastqc/functions.nf create mode 100644 modules/nf-core/modules/fastqc/main.nf create mode 100644 modules/nf-core/modules/fastqc/meta.yml create mode 100644 modules/nf-core/modules/multiqc/functions.nf create mode 100644 modules/nf-core/modules/multiqc/main.nf create mode 100644 modules/nf-core/modules/multiqc/meta.yml create mode 100644 subworkflows/local/input_check.nf create mode 100644 workflows/chipseq.nf diff --git a/.editorconfig b/.editorconfig new file mode 100644 index 000000000..afb20bb1e --- /dev/null +++ b/.editorconfig @@ -0,0 +1,24 @@ +root = true + +[*] +charset = utf-8 +end_of_line = lf +insert_final_newline = true +trim_trailing_whitespace = true +indent_size = 4 +indent_style = space + +[*.{yml,yaml}] +indent_size = 2 + +# These files are edited and tested upstream in nf-core/modules +[/modules/nf-core/**] +charset = unset +end_of_line = unset +insert_final_newline = unset +trim_trailing_whitespace = unset +indent_style = unset +indent_size = unset + +[/assets/email*] +indent_size = unset diff --git a/.github/CONTRIBUTING.md b/.github/CONTRIBUTING.md index 81a0933ea..af4dba190 100644 --- a/.github/CONTRIBUTING.md +++ b/.github/CONTRIBUTING.md @@ -74,7 +74,7 @@ If you wish to contribute a new step, please use the following coding standards: 7. Add sanity checks for all relevant parameters. 8. Add any new software to the `scrape_software_versions.py` script in `bin/` and the version command to the `scrape_software_versions` process in `main.nf`. 9. Do local tests that the new code works properly and as expected. -10. Add a new test command in `.github/workflow/ci.yaml`. +10. Add a new test command in `.github/workflow/ci.yml`. 11. If applicable add a [MultiQC](https://https://multiqc.info/) module. 12. Update MultiQC config `assets/multiqc_config.yaml` so relevant suffixes, name clean up, General Statistics Table column order, and module figures are in the right order. 13. Optional: Add any descriptions of MultiQC report sections and output files to `docs/output.md`. diff --git a/.github/ISSUE_TEMPLATE/bug_report.md b/.github/ISSUE_TEMPLATE/bug_report.md index 7e6f4d86a..dbc527cc8 100644 --- a/.github/ISSUE_TEMPLATE/bug_report.md +++ b/.github/ISSUE_TEMPLATE/bug_report.md @@ -18,7 +18,7 @@ Please delete this text and anything that's not relevant from the template below I have checked the following places for your error: - [ ] [nf-core website: troubleshooting](https://nf-co.re/usage/troubleshooting) -- [ ] [nf-core/chipseq pipeline documentation](https://nf-co.re/nf-core/chipseq/usage) +- [ ] [nf-core/chipseq pipeline documentation](https://nf-co.re/chipseq/usage) ## Description of the bug @@ -51,13 +51,12 @@ Have you provided the following extra information/files: ## Nextflow Installation -- Version: +- Version: ## Container engine - Engine: - version: -- Image tag: ## Additional context diff --git a/.github/PULL_REQUEST_TEMPLATE.md b/.github/PULL_REQUEST_TEMPLATE.md index f782cf452..8a29e2412 100644 --- a/.github/PULL_REQUEST_TEMPLATE.md +++ b/.github/PULL_REQUEST_TEMPLATE.md @@ -16,8 +16,7 @@ Learn more about contributing: [CONTRIBUTING.md](https://github.com/nf-core/chip - [ ] This comment contains a description of changes (with reason). - [ ] If you've fixed a bug or added code that should be tested, add tests! - - [ ] If you've added a new tool - add to the software_versions process and a regex to `scrape_software_versions.py` - - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) + - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) - [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. - [ ] Make sure your code lints (`nf-core lint .`). - [ ] Ensure the test suite passes (`nextflow run . -profile test,docker`). diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index 3f1420d3b..906aa559c 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -1,46 +1,34 @@ name: nf-core AWS full size tests # This workflow is triggered on published releases. -# It can be additionally triggered manually with GitHub actions workflow dispatch. +# It can be additionally triggered manually with GitHub actions workflow dispatch button. # It runs the -profile 'test_full' on AWS batch on: - workflow_run: - workflows: ["nf-core Docker push (release)"] - types: [completed] + release: + types: [published] workflow_dispatch: - - -env: - AWS_ACCESS_KEY_ID: ${{ secrets.AWS_ACCESS_KEY_ID }} - AWS_SECRET_ACCESS_KEY: ${{ secrets.AWS_SECRET_ACCESS_KEY }} - TOWER_ACCESS_TOKEN: ${{ secrets.AWS_TOWER_TOKEN }} - AWS_JOB_DEFINITION: ${{ secrets.AWS_JOB_DEFINITION }} - AWS_JOB_QUEUE: ${{ secrets.AWS_JOB_QUEUE }} - AWS_S3_BUCKET: ${{ secrets.AWS_S3_BUCKET }} - - jobs: - run-awstest: + run-tower: name: Run AWS full tests if: github.repository == 'nf-core/chipseq' runs-on: ubuntu-latest steps: - - name: Setup Miniconda - uses: conda-incubator/setup-miniconda@v2 - with: - auto-update-conda: true - python-version: 3.7 - - name: Install awscli - run: conda install -c conda-forge awscli - - name: Start AWS batch job + - name: Launch workflow via tower + uses: nf-core/tower-action@master # TODO nf-core: You can customise AWS full pipeline tests as required # Add full size test data (but still relatively small datasets for few samples) # on the `test_full.config` test runs with only one set of parameters - # Then specify `-profile test_full` instead of `-profile test` on the AWS batch command - run: | - aws batch submit-job \ - --region eu-west-1 \ - --job-name nf-core-chipseq \ - --job-queue $AWS_JOB_QUEUE \ - --job-definition $AWS_JOB_DEFINITION \ - --container-overrides '{"command": ["nf-core/chipseq", "-r '"${GITHUB_SHA}"' -profile test --outdir s3://'"${AWS_S3_BUCKET}"'/chipseq/results-'"${GITHUB_SHA}"' -w s3://'"${AWS_S3_BUCKET}"'/chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}' + + with: + workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }} + bearer_token: ${{ secrets.TOWER_BEARER_TOKEN }} + compute_env: ${{ secrets.TOWER_COMPUTE_ENV }} + pipeline: ${{ github.repository }} + revision: ${{ github.sha }} + workdir: s3://${{ secrets.AWS_S3_BUCKET }}/work/chipseq/work-${{ github.sha }} + parameters: | + { + "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-${{ github.sha }}" + } + profiles: '[ "test_full", "aws_tower" ]' + diff --git a/.github/workflows/awstest.yml b/.github/workflows/awstest.yml index 83bf06058..6fc417220 100644 --- a/.github/workflows/awstest.yml +++ b/.github/workflows/awstest.yml @@ -1,42 +1,28 @@ name: nf-core AWS test -# This workflow is triggered on push to the master branch. -# It can be additionally triggered manually with GitHub actions workflow dispatch. -# It runs the -profile 'test' on AWS batch. +# This workflow can be triggered manually with the GitHub actions workflow dispatch button. +# It runs the -profile 'test' on AWS batch on: workflow_dispatch: - - -env: - AWS_ACCESS_KEY_ID: ${{ secrets.AWS_ACCESS_KEY_ID }} - AWS_SECRET_ACCESS_KEY: ${{ secrets.AWS_SECRET_ACCESS_KEY }} - TOWER_ACCESS_TOKEN: ${{ secrets.AWS_TOWER_TOKEN }} - AWS_JOB_DEFINITION: ${{ secrets.AWS_JOB_DEFINITION }} - AWS_JOB_QUEUE: ${{ secrets.AWS_JOB_QUEUE }} - AWS_S3_BUCKET: ${{ secrets.AWS_S3_BUCKET }} - - jobs: - run-awstest: + run-tower: name: Run AWS tests if: github.repository == 'nf-core/chipseq' runs-on: ubuntu-latest steps: - - name: Setup Miniconda - uses: conda-incubator/setup-miniconda@v2 + - name: Launch workflow via tower + uses: nf-core/tower-action@master + with: - auto-update-conda: true - python-version: 3.7 - - name: Install awscli - run: conda install -c conda-forge awscli - - name: Start AWS batch job - # TODO nf-core: You can customise CI pipeline run tests as required - # For example: adding multiple test runs with different parameters - # Remember that you can parallelise this by using strategy.matrix - run: | - aws batch submit-job \ - --region eu-west-1 \ - --job-name nf-core-chipseq \ - --job-queue $AWS_JOB_QUEUE \ - --job-definition $AWS_JOB_DEFINITION \ - --container-overrides '{"command": ["nf-core/chipseq", "-r '"${GITHUB_SHA}"' -profile test --outdir s3://'"${AWS_S3_BUCKET}"'/chipseq/results-'"${GITHUB_SHA}"' -w s3://'"${AWS_S3_BUCKET}"'/chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}' + workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }} + bearer_token: ${{ secrets.TOWER_BEARER_TOKEN }} + compute_env: ${{ secrets.TOWER_COMPUTE_ENV }} + pipeline: ${{ github.repository }} + revision: ${{ github.sha }} + workdir: s3://${{ secrets.AWS_S3_BUCKET }}/work/chipseq/work-${{ github.sha }} + parameters: | + { + "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-${{ github.sha }}" + } + profiles: '[ "test", "aws_tower" ]' + diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 6123bcbc2..1e8f2eba4 100644 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -23,28 +23,11 @@ jobs: strategy: matrix: # Nextflow versions: check pipeline minimum and current latest - nxf_ver: ['20.04.0', ''] + nxf_ver: ['21.04.0', ''] steps: - name: Check out pipeline code uses: actions/checkout@v2 - - name: Check if Dockerfile or Conda environment changed - uses: technote-space/get-diff-action@v4 - with: - FILES: | - Dockerfile - environment.yml - - - name: Build new docker image - if: env.MATCHED_FILES - run: docker build --no-cache . -t nfcore/chipseq:dev - - - name: Pull docker image - if: ${{ !env.MATCHED_FILES }} - run: | - docker pull nfcore/chipseq:dev - docker tag nfcore/chipseq:dev nfcore/chipseq:dev - - name: Install Nextflow env: CAPSULE_LOG: none diff --git a/.github/workflows/linting.yml b/.github/workflows/linting.yml index fcde400ce..13b4fc818 100644 --- a/.github/workflows/linting.yml +++ b/.github/workflows/linting.yml @@ -18,7 +18,7 @@ jobs: - name: Install markdownlint run: npm install -g markdownlint-cli - name: Run Markdownlint - run: markdownlint ${GITHUB_WORKSPACE} -c ${GITHUB_WORKSPACE}/.github/markdownlint.yml + run: markdownlint . # If the above check failed, post a comment on the PR explaining the failure - name: Post PR comment @@ -35,8 +35,8 @@ jobs: * On Mac: `brew install markdownlint-cli` * Everything else: [Install `npm`](https://www.npmjs.com/get-npm) then [install `markdownlint-cli`](https://www.npmjs.com/package/markdownlint-cli) (`npm install -g markdownlint-cli`) * Fix the markdown errors - * Automatically: `markdownlint . --config .github/markdownlint.yml --fix` - * Manually resolve anything left from `markdownlint . --config .github/markdownlint.yml` + * Automatically: `markdownlint . --fix` + * Manually resolve anything left from `markdownlint .` Once you push these changes the test should pass, and you can hide this comment :+1: @@ -46,6 +46,20 @@ jobs: repo-token: ${{ secrets.GITHUB_TOKEN }} allow-repeats: false + EditorConfig: + runs-on: ubuntu-latest + steps: + - uses: actions/checkout@v2 + + - uses: actions/setup-node@v1 + with: + node-version: "10" + + - name: Install editorconfig-checker + run: npm install -g editorconfig-checker + + - name: Run ECLint check + run: editorconfig-checker -exclude README.md $(git ls-files | grep -v test) YAML: runs-on: ubuntu-latest @@ -84,7 +98,6 @@ jobs: repo-token: ${{ secrets.GITHUB_TOKEN }} allow-repeats: false - nf-core: runs-on: ubuntu-latest steps: diff --git a/.github/workflows/push_dockerhub_dev.yml b/.github/workflows/push_dockerhub_dev.yml deleted file mode 100644 index 828dc0fa8..000000000 --- a/.github/workflows/push_dockerhub_dev.yml +++ /dev/null @@ -1,28 +0,0 @@ -name: nf-core Docker push (dev) -# This builds the docker image and pushes it to DockerHub -# Runs on nf-core repo releases and push event to 'dev' branch (PR merges) -on: - push: - branches: - - dev - -jobs: - push_dockerhub: - name: Push new Docker image to Docker Hub (dev) - runs-on: ubuntu-latest - # Only run for the nf-core repo, for releases and merged PRs - if: ${{ github.repository == 'nf-core/chipseq' }} - env: - DOCKERHUB_USERNAME: ${{ secrets.DOCKERHUB_USERNAME }} - DOCKERHUB_PASS: ${{ secrets.DOCKERHUB_PASS }} - steps: - - name: Check out pipeline code - uses: actions/checkout@v2 - - - name: Build new docker image - run: docker build --no-cache . -t nfcore/chipseq:dev - - - name: Push Docker image to DockerHub (dev) - run: | - echo "$DOCKERHUB_PASS" | docker login -u "$DOCKERHUB_USERNAME" --password-stdin - docker push nfcore/chipseq:dev diff --git a/.github/workflows/push_dockerhub_release.yml b/.github/workflows/push_dockerhub_release.yml deleted file mode 100644 index 69cfe042a..000000000 --- a/.github/workflows/push_dockerhub_release.yml +++ /dev/null @@ -1,29 +0,0 @@ -name: nf-core Docker push (release) -# This builds the docker image and pushes it to DockerHub -# Runs on nf-core repo releases and push event to 'dev' branch (PR merges) -on: - release: - types: [published] - -jobs: - push_dockerhub: - name: Push new Docker image to Docker Hub (release) - runs-on: ubuntu-latest - # Only run for the nf-core repo, for releases and merged PRs - if: ${{ github.repository == 'nf-core/chipseq' }} - env: - DOCKERHUB_USERNAME: ${{ secrets.DOCKERHUB_USERNAME }} - DOCKERHUB_PASS: ${{ secrets.DOCKERHUB_PASS }} - steps: - - name: Check out pipeline code - uses: actions/checkout@v2 - - - name: Build new docker image - run: docker build --no-cache . -t nfcore/chipseq:latest - - - name: Push Docker image to DockerHub (release) - run: | - echo "$DOCKERHUB_PASS" | docker login -u "$DOCKERHUB_USERNAME" --password-stdin - docker push nfcore/chipseq:latest - docker tag nfcore/chipseq:latest nfcore/chipseq:${{ github.event.release.tag_name }} - docker push nfcore/chipseq:${{ github.event.release.tag_name }} diff --git a/.gitignore b/.gitignore index aa4bb5b37..5124c9ac7 100644 --- a/.gitignore +++ b/.gitignore @@ -3,7 +3,6 @@ work/ data/ results/ .DS_Store -tests/ testing/ testing* *.pyc diff --git a/.github/markdownlint.yml b/.markdownlint.yml similarity index 90% rename from .github/markdownlint.yml rename to .markdownlint.yml index 8d7eb53b0..9e605fcfa 100644 --- a/.github/markdownlint.yml +++ b/.markdownlint.yml @@ -1,6 +1,8 @@ # Markdownlint configuration file default: true line-length: false +ul-indent: + indent: 4 no-duplicate-header: siblings_only: true no-inline-html: diff --git a/CITATIONS.md b/CITATIONS.md new file mode 100644 index 000000000..89046a380 --- /dev/null +++ b/CITATIONS.md @@ -0,0 +1,32 @@ +# nf-core/chipseq: Citations + +## [nf-core](https://pubmed.ncbi.nlm.nih.gov/32055031/) + +> Ewels PA, Peltzer A, Fillinger S, Patel H, Alneberg J, Wilm A, Garcia MU, Di Tommaso P, Nahnsen S. The nf-core framework for community-curated bioinformatics pipelines. Nat Biotechnol. 2020 Mar;38(3):276-278. doi: 10.1038/s41587-020-0439-x. PubMed PMID: 32055031. + +## [Nextflow](https://pubmed.ncbi.nlm.nih.gov/28398311/) + +> Di Tommaso P, Chatzou M, Floden EW, Barja PP, Palumbo E, Notredame C. Nextflow enables reproducible computational workflows. Nat Biotechnol. 2017 Apr 11;35(4):316-319. doi: 10.1038/nbt.3820. PubMed PMID: 28398311. + +## Pipeline tools + +* [FastQC](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/) + +* [MultiQC](https://www.ncbi.nlm.nih.gov/pubmed/27312411/) + > Ewels P, Magnusson M, Lundin S, Käller M. MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics. 2016 Oct 1;32(19):3047-8. doi: 10.1093/bioinformatics/btw354. Epub 2016 Jun 16. PubMed PMID: 27312411; PubMed Central PMCID: PMC5039924. + +## Software packaging/containerisation tools + +* [Anaconda](https://anaconda.com) + > Anaconda Software Distribution. Computer software. Vers. 2-2.4.0. Anaconda, Nov. 2016. Web. + +* [Bioconda](https://pubmed.ncbi.nlm.nih.gov/29967506/) + > Grüning B, Dale R, Sjödin A, Chapman BA, Rowe J, Tomkins-Tinch CH, Valieris R, Köster J; Bioconda Team. Bioconda: sustainable and comprehensive software distribution for the life sciences. Nat Methods. 2018 Jul;15(7):475-476. doi: 10.1038/s41592-018-0046-7. PubMed PMID: 29967506. + +* [BioContainers](https://pubmed.ncbi.nlm.nih.gov/28379341/) + > da Veiga Leprevost F, Grüning B, Aflitos SA, Röst HL, Uszkoreit J, Barsnes H, Vaudel M, Moreno P, Gatto L, Weber J, Bai M, Jimenez RC, Sachsenberg T, Pfeuffer J, Alvarez RV, Griss J, Nesvizhskii AI, Perez-Riverol Y. BioContainers: an open-source and community-driven framework for software standardization. Bioinformatics. 2017 Aug 15;33(16):2580-2582. doi: 10.1093/bioinformatics/btx192. PubMed PMID: 28379341; PubMed Central PMCID: PMC5870671. + +* [Docker](https://dl.acm.org/doi/10.5555/2600239.2600241) + +* [Singularity](https://pubmed.ncbi.nlm.nih.gov/28494014/) + > Kurtzer GM, Sochat V, Bauer MW. Singularity: Scientific containers for mobility of compute. PLoS One. 2017 May 11;12(5):e0177459. doi: 10.1371/journal.pone.0177459. eCollection 2017. PubMed PMID: 28494014; PubMed Central PMCID: PMC5426675. diff --git a/Dockerfile b/Dockerfile deleted file mode 100644 index be6f50b2f..000000000 --- a/Dockerfile +++ /dev/null @@ -1,13 +0,0 @@ -FROM nfcore/base:1.14 -LABEL authors="Philip Ewels" \ - description="Docker image containing all software requirements for the nf-core/chipseq pipeline" - -# Install the conda environment -COPY environment.yml / -RUN conda env create --quiet -f /environment.yml && conda clean -a - -# Add conda installation dir to PATH (instead of doing 'conda activate') -ENV PATH /opt/conda/envs/nf-core-chipseq-1.3.0dev/bin:$PATH - -# Dump the details of the installed packages to a file for posterity -RUN conda env export --name nf-core-chipseq-1.3.0dev > nf-core-chipseq-1.3.0dev.yml diff --git a/README.md b/README.md index 1f0ee33a7..21f112264 100644 --- a/README.md +++ b/README.md @@ -1,67 +1,69 @@ # ![nf-core/chipseq](docs/images/nf-core-chipseq_logo.png) -**ChIP-seq peak-calling and differential analysis pipeline.**. +[![GitHub Actions CI Status](https://github.com/nf-core/chipseq/workflows/nf-core%20CI/badge.svg)](https://github.com/nf-core/chipseq/actions?query=workflow%3A%22nf-core+CI%22) +[![GitHub Actions Linting Status](https://github.com/nf-core/chipseq/workflows/nf-core%20linting/badge.svg)](https://github.com/nf-core/chipseq/actions?query=workflow%3A%22nf-core+linting%22) +[![AWS CI](https://img.shields.io/badge/CI%20tests-full%20size-FF9900?labelColor=000000&logo=Amazon%20AWS)](https://nf-co.re/chipseq/results) +[![Cite with Zenodo](http://img.shields.io/badge/DOI-10.5281/zenodo.XXXXXXX-1073c8?labelColor=000000)](https://doi.org/10.5281/zenodo.XXXXXXX) -[![GitHub Actions CI Status](https://github.com/nf-core/chipseq/workflows/nf-core%20CI/badge.svg)](https://github.com/nf-core/chipseq/actions) -[![GitHub Actions Linting Status](https://github.com/nf-core/chipseq/workflows/nf-core%20linting/badge.svg)](https://github.com/nf-core/chipseq/actions) -[![Nextflow](https://img.shields.io/badge/nextflow-%E2%89%A520.04.0-brightgreen.svg)](https://www.nextflow.io/) +[![Nextflow](https://img.shields.io/badge/nextflow%20DSL2-%E2%89%A521.04.0-23aa62.svg?labelColor=000000)](https://www.nextflow.io/) +[![run with conda](http://img.shields.io/badge/run%20with-conda-3EB049?labelColor=000000&logo=anaconda)](https://docs.conda.io/en/latest/) +[![run with docker](https://img.shields.io/badge/run%20with-docker-0db7ed?labelColor=000000&logo=docker)](https://www.docker.com/) +[![run with singularity](https://img.shields.io/badge/run%20with-singularity-1d355c.svg?labelColor=000000)](https://sylabs.io/docs/) -[![install with bioconda](https://img.shields.io/badge/install%20with-bioconda-brightgreen.svg)](https://bioconda.github.io/) -[![Docker](https://img.shields.io/docker/automated/nfcore/chipseq.svg)](https://hub.docker.com/r/nfcore/chipseq) -[![Get help on Slack](http://img.shields.io/badge/slack-nf--core%20%23chipseq-4A154B?logo=slack)](https://nfcore.slack.com/channels/chipseq) +[![Get help on Slack](http://img.shields.io/badge/slack-nf--core%20%23chipseq-4A154B?labelColor=000000&logo=slack)](https://nfcore.slack.com/channels/chipseq) +[![Follow on Twitter](http://img.shields.io/badge/twitter-%40nf__core-1DA1F2?labelColor=000000&logo=twitter)](https://twitter.com/nf_core) +[![Watch on YouTube](http://img.shields.io/badge/youtube-nf--core-FF0000?labelColor=000000&logo=youtube)](https://www.youtube.com/c/nf-core) ## Introduction -**nf-core/chipseq** is a bioinformatics best-practise analysis pipeline for +**nf-core/chipseq** is a bioinformatics best-practice analysis pipeline for ChIP-seq peak-calling and differential analysis pipeline.. -The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool to run tasks across multiple compute infrastructures in a very portable manner. It comes with docker containers making installation trivial and results highly reproducible. +The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool to run tasks across multiple compute infrastructures in a very portable manner. It uses Docker/Singularity containers making installation trivial and results highly reproducible. The [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) implementation of this pipeline uses one container per process which makes it much easier to maintain and update software dependencies. Where possible, these processes have been submitted to and installed from [nf-core/modules](https://github.com/nf-core/modules) in order to make them available to all nf-core pipelines, and to everyone within the Nextflow community! + + +On release, automated continuous integration tests run the pipeline on a full-sized dataset on the AWS cloud infrastructure. This ensures that the pipeline runs on AWS, has sensible resource allocation defaults set to run on real-world datasets, and permits the persistent storage of results to benchmark between pipeline releases and other analysis sources. The results obtained from the full-sized test can be viewed on the [nf-core website](https://nf-co.re/chipseq/results). + +## Pipeline summary + + + +1. Read QC ([`FastQC`](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/)) +2. Present QC for raw reads ([`MultiQC`](http://multiqc.info/)) ## Quick Start -1. Install [`nextflow`](https://nf-co.re/usage/installation) (`>=20.04.0`) +1. Install [`Nextflow`](https://nf-co.re/usage/installation) (`>=21.04.0`) 2. Install any of [`Docker`](https://docs.docker.com/engine/installation/), [`Singularity`](https://www.sylabs.io/guides/3.0/user-guide/), [`Podman`](https://podman.io/), [`Shifter`](https://nersc.gitlab.io/development/shifter/how-to-use/) or [`Charliecloud`](https://hpc.github.io/charliecloud/) for full pipeline reproducibility _(please only use [`Conda`](https://conda.io/miniconda.html) as a last resort; see [docs](https://nf-co.re/usage/configuration#basic-configuration-profiles))_ 3. Download the pipeline and test it on a minimal dataset with a single command: - ```bash + ```console nextflow run nf-core/chipseq -profile test, ``` - > Please check [nf-core/configs](https://github.com/nf-core/configs#documentation) to see if a custom config file to run nf-core pipelines already exists for your Institute. If so, you can simply use `-profile ` in your command. This will enable either `docker` or `singularity` and set the appropriate execution settings for your local compute environment. + > * Please check [nf-core/configs](https://github.com/nf-core/configs#documentation) to see if a custom config file to run nf-core pipelines already exists for your Institute. If so, you can simply use `-profile ` in your command. This will enable either `docker` or `singularity` and set the appropriate execution settings for your local compute environment. + > * If you are using `singularity` then the pipeline will auto-detect this and attempt to download the Singularity images directly as opposed to performing a conversion from Docker images. If you are persistently observing issues downloading Singularity images directly due to timeout or network issues then please use the `--singularity_pull_docker_container` parameter to pull and convert the Docker image instead. Alternatively, it is highly recommended to use the [`nf-core download`](https://nf-co.re/tools/#downloading-pipelines-for-offline-use) command to pre-download all of the required containers before running the pipeline and to set the [`NXF_SINGULARITY_CACHEDIR` or `singularity.cacheDir`](https://www.nextflow.io/docs/latest/singularity.html?#singularity-docker-hub) Nextflow options to be able to store and re-use the images from a central location for future pipeline runs. + > * If you are using `conda`, it is highly recommended to use the [`NXF_CONDA_CACHEDIR` or `conda.cacheDir`](https://www.nextflow.io/docs/latest/conda.html) settings to store the environments in a central location for future pipeline runs. 4. Start running your own analysis! - ```bash - nextflow run nf-core/chipseq -profile --input '*_R{1,2}.fastq.gz' --genome GRCh37 + ```console + nextflow run nf-core/chipseq -profile --input samplesheet.csv --genome GRCh37 ``` -See [usage docs](https://nf-co.re/chipseq/usage) for all of the available options when running the pipeline. - -## Pipeline Summary - -By default, the pipeline currently performs the following: - - - -* Sequencing quality control (`FastQC`) -* Overall pipeline run summaries (`MultiQC`) - ## Documentation -The nf-core/chipseq pipeline comes with documentation about the pipeline: [usage](https://nf-co.re/chipseq/usage) and [output](https://nf-co.re/chipseq/output). - - +The nf-core/chipseq pipeline comes with documentation about the pipeline [usage](https://nf-co.re/chipseq/usage), [parameters](https://nf-co.re/chipseq/parameters) and [output](https://nf-co.re/chipseq/output). ## Credits nf-core/chipseq was originally written by Philip Ewels. -We thank the following people for their extensive assistance in the development -of this pipeline: +We thank the following people for their extensive assistance in the development of this pipeline: @@ -73,9 +75,12 @@ For further information or help, don't hesitate to get in touch on the [Slack `# ## Citations - + + +An extensive list of references for the tools used by the pipeline can be found in the [`CITATIONS.md`](CITATIONS.md) file. + You can cite the `nf-core` publication as follows: > **The nf-core framework for community-curated bioinformatics pipelines.** @@ -83,7 +88,3 @@ You can cite the `nf-core` publication as follows: > Philip Ewels, Alexander Peltzer, Sven Fillinger, Harshil Patel, Johannes Alneberg, Andreas Wilm, Maxime Ulysse Garcia, Paolo Di Tommaso & Sven Nahnsen. > > _Nat Biotechnol._ 2020 Feb 13. doi: [10.1038/s41587-020-0439-x](https://dx.doi.org/10.1038/s41587-020-0439-x). - -In addition, references of tools and data used in this pipeline are as follows: - - diff --git a/assets/samplesheet.csv b/assets/samplesheet.csv new file mode 100644 index 000000000..5f653ab7b --- /dev/null +++ b/assets/samplesheet.csv @@ -0,0 +1,3 @@ +sample,fastq_1,fastq_2 +SAMPLE_PAIRED_END,/path/to/fastq/files/AEG588A1_S1_L002_R1_001.fastq.gz,/path/to/fastq/files/AEG588A1_S1_L002_R2_001.fastq.gz +SAMPLE_SINGLE_END,/path/to/fastq/files/AEG588A4_S4_L003_R1_001.fastq.gz, diff --git a/assets/schema_input.json b/assets/schema_input.json new file mode 100644 index 000000000..a024fd708 --- /dev/null +++ b/assets/schema_input.json @@ -0,0 +1,39 @@ +{ + "$schema": "http://json-schema.org/draft-07/schema", + "$id": "https://raw.githubusercontent.com/nf-core/chipseq/master/assets/schema_input.json", + "title": "nf-core/chipseq pipeline - params.input schema", + "description": "Schema for the file provided with params.input", + "type": "array", + "items": { + "type": "object", + "properties": { + "sample": { + "type": "string", + "pattern": "^\\S+$", + "errorMessage": "Sample name must be provided and cannot contain spaces" + }, + "fastq_1": { + "type": "string", + "pattern": "^\\S+\\.f(ast)?q\\.gz$", + "errorMessage": "FastQ file for reads 1 must be provided, cannot contain spaces and must have extension '.fq.gz' or '.fastq.gz'" + }, + "fastq_2": { + "errorMessage": "FastQ file for reads 2 cannot contain spaces and must have extension '.fq.gz' or '.fastq.gz'", + "anyOf": [ + { + "type": "string", + "pattern": "^\\S+\\.f(ast)?q\\.gz$" + }, + { + "type": "string", + "maxLength": 0 + } + ] + } + }, + "required": [ + "sample", + "fastq_1" + ] + } +} diff --git a/assets/sendmail_template.txt b/assets/sendmail_template.txt index f46cdb701..1da35e63f 100644 --- a/assets/sendmail_template.txt +++ b/assets/sendmail_template.txt @@ -15,15 +15,15 @@ Content-ID: Content-Disposition: inline; filename="nf-core-chipseq_logo.png" <% out << new File("$projectDir/assets/nf-core-chipseq_logo.png"). - bytes. - encodeBase64(). - toString(). - tokenize( '\n' )*. - toList()*. - collate( 76 )*. - collect { it.join() }. - flatten(). - join( '\n' ) %> + bytes. + encodeBase64(). + toString(). + tokenize( '\n' )*. + toList()*. + collate( 76 )*. + collect { it.join() }. + flatten(). + join( '\n' ) %> <% if (mqcFile){ @@ -37,15 +37,15 @@ Content-ID: Content-Disposition: attachment; filename=\"${mqcFileObj.getName()}\" ${mqcFileObj. - bytes. - encodeBase64(). - toString(). - tokenize( '\n' )*. - toList()*. - collate( 76 )*. - collect { it.join() }. - flatten(). - join( '\n' )} + bytes. + encodeBase64(). + toString(). + tokenize( '\n' )*. + toList()*. + collate( 76 )*. + collect { it.join() }. + flatten(). + join( '\n' )} """ }} %> diff --git a/bin/check_samplesheet.py b/bin/check_samplesheet.py new file mode 100755 index 000000000..a47ce7e57 --- /dev/null +++ b/bin/check_samplesheet.py @@ -0,0 +1,146 @@ +#!/usr/bin/env python + +# TODO nf-core: Update the script to check the samplesheet +# This script is based on the example at: https://raw.githubusercontent.com/nf-core/test-datasets/viralrecon/samplesheet/samplesheet_test_illumina_amplicon.csv + +import os +import sys +import errno +import argparse + + +def parse_args(args=None): + Description = "Reformat nf-core/chipseq samplesheet file and check its contents." + Epilog = "Example usage: python check_samplesheet.py " + + parser = argparse.ArgumentParser(description=Description, epilog=Epilog) + parser.add_argument("FILE_IN", help="Input samplesheet file.") + parser.add_argument("FILE_OUT", help="Output file.") + return parser.parse_args(args) + + +def make_dir(path): + if len(path) > 0: + try: + os.makedirs(path) + except OSError as exception: + if exception.errno != errno.EEXIST: + raise exception + + +def print_error(error, context="Line", context_str=""): + error_str = "ERROR: Please check samplesheet -> {}".format(error) + if context != "" and context_str != "": + error_str = "ERROR: Please check samplesheet -> {}\n{}: '{}'".format( + error, context.strip(), context_str.strip() + ) + print(error_str) + sys.exit(1) + + +# TODO nf-core: Update the check_samplesheet function +def check_samplesheet(file_in, file_out): + """ + This function checks that the samplesheet follows the following structure: + + sample,fastq_1,fastq_2 + SAMPLE_PE,SAMPLE_PE_RUN1_1.fastq.gz,SAMPLE_PE_RUN1_2.fastq.gz + SAMPLE_PE,SAMPLE_PE_RUN2_1.fastq.gz,SAMPLE_PE_RUN2_2.fastq.gz + SAMPLE_SE,SAMPLE_SE_RUN1_1.fastq.gz, + + For an example see: + https://raw.githubusercontent.com/nf-core/test-datasets/viralrecon/samplesheet/samplesheet_test_illumina_amplicon.csv + """ + + sample_mapping_dict = {} + with open(file_in, "r") as fin: + + ## Check header + MIN_COLS = 2 + # TODO nf-core: Update the column names for the input samplesheet + HEADER = ["sample", "fastq_1", "fastq_2"] + header = [x.strip('"') for x in fin.readline().strip().split(",")] + if header[: len(HEADER)] != HEADER: + print("ERROR: Please check samplesheet header -> {} != {}".format(",".join(header), ",".join(HEADER))) + sys.exit(1) + + ## Check sample entries + for line in fin: + lspl = [x.strip().strip('"') for x in line.strip().split(",")] + + # Check valid number of columns per row + if len(lspl) < len(HEADER): + print_error( + "Invalid number of columns (minimum = {})!".format(len(HEADER)), + "Line", + line, + ) + num_cols = len([x for x in lspl if x]) + if num_cols < MIN_COLS: + print_error( + "Invalid number of populated columns (minimum = {})!".format(MIN_COLS), + "Line", + line, + ) + + ## Check sample name entries + sample, fastq_1, fastq_2 = lspl[: len(HEADER)] + sample = sample.replace(" ", "_") + if not sample: + print_error("Sample entry has not been specified!", "Line", line) + + ## Check FastQ file extension + for fastq in [fastq_1, fastq_2]: + if fastq: + if fastq.find(" ") != -1: + print_error("FastQ file contains spaces!", "Line", line) + if not fastq.endswith(".fastq.gz") and not fastq.endswith(".fq.gz"): + print_error( + "FastQ file does not have extension '.fastq.gz' or '.fq.gz'!", + "Line", + line, + ) + + ## Auto-detect paired-end/single-end + sample_info = [] ## [single_end, fastq_1, fastq_2] + if sample and fastq_1 and fastq_2: ## Paired-end short reads + sample_info = ["0", fastq_1, fastq_2] + elif sample and fastq_1 and not fastq_2: ## Single-end short reads + sample_info = ["1", fastq_1, fastq_2] + else: + print_error("Invalid combination of columns provided!", "Line", line) + + ## Create sample mapping dictionary = { sample: [ single_end, fastq_1, fastq_2 ] } + if sample not in sample_mapping_dict: + sample_mapping_dict[sample] = [sample_info] + else: + if sample_info in sample_mapping_dict[sample]: + print_error("Samplesheet contains duplicate rows!", "Line", line) + else: + sample_mapping_dict[sample].append(sample_info) + + ## Write validated samplesheet with appropriate columns + if len(sample_mapping_dict) > 0: + out_dir = os.path.dirname(file_out) + make_dir(out_dir) + with open(file_out, "w") as fout: + fout.write(",".join(["sample", "single_end", "fastq_1", "fastq_2"]) + "\n") + for sample in sorted(sample_mapping_dict.keys()): + + ## Check that multiple runs of the same sample are of the same datatype + if not all(x[0] == sample_mapping_dict[sample][0][0] for x in sample_mapping_dict[sample]): + print_error("Multiple runs of a sample must be of the same datatype!", "Sample: {}".format(sample)) + + for idx, val in enumerate(sample_mapping_dict[sample]): + fout.write(",".join(["{}_T{}".format(sample, idx + 1)] + val) + "\n") + else: + print_error("No entries to process!", "Samplesheet: {}".format(file_in)) + + +def main(args=None): + args = parse_args(args) + check_samplesheet(args.FILE_IN, args.FILE_OUT) + + +if __name__ == "__main__": + sys.exit(main()) diff --git a/bin/markdown_to_html.py b/bin/markdown_to_html.py deleted file mode 100755 index a26d1ff5e..000000000 --- a/bin/markdown_to_html.py +++ /dev/null @@ -1,91 +0,0 @@ -#!/usr/bin/env python -from __future__ import print_function -import argparse -import markdown -import os -import sys -import io - - -def convert_markdown(in_fn): - input_md = io.open(in_fn, mode="r", encoding="utf-8").read() - html = markdown.markdown( - "[TOC]\n" + input_md, - extensions=["pymdownx.extra", "pymdownx.b64", "pymdownx.highlight", "pymdownx.emoji", "pymdownx.tilde", "toc"], - extension_configs={ - "pymdownx.b64": {"base_path": os.path.dirname(in_fn)}, - "pymdownx.highlight": {"noclasses": True}, - "toc": {"title": "Table of Contents"}, - }, - ) - return html - - -def wrap_html(contents): - header = """ - - - - - -

- """ - footer = """ -
- - - """ - return header + contents + footer - - -def parse_args(args=None): - parser = argparse.ArgumentParser() - parser.add_argument("mdfile", type=argparse.FileType("r"), nargs="?", help="File to convert. Defaults to stdin.") - parser.add_argument( - "-o", "--out", type=argparse.FileType("w"), default=sys.stdout, help="Output file name. Defaults to stdout." - ) - return parser.parse_args(args) - - -def main(args=None): - args = parse_args(args) - converted_md = convert_markdown(args.mdfile.name) - html = wrap_html(converted_md) - args.out.write(html) - - -if __name__ == "__main__": - sys.exit(main()) diff --git a/bin/scrape_software_versions.py b/bin/scrape_software_versions.py index f2d0a5cf2..884897195 100755 --- a/bin/scrape_software_versions.py +++ b/bin/scrape_software_versions.py @@ -1,36 +1,18 @@ #!/usr/bin/env python from __future__ import print_function -from collections import OrderedDict -import re +import os -# TODO nf-core: Add additional regexes for new tools in process get_software_versions -regexes = { - "nf-core/chipseq": ["v_pipeline.txt", r"(\S+)"], - "Nextflow": ["v_nextflow.txt", r"(\S+)"], - "FastQC": ["v_fastqc.txt", r"FastQC v(\S+)"], - "MultiQC": ["v_multiqc.txt", r"multiqc, version (\S+)"], -} -results = OrderedDict() -results["nf-core/chipseq"] = 'N/A' -results["Nextflow"] = 'N/A' -results["FastQC"] = 'N/A' -results["MultiQC"] = 'N/A' +results = {} +version_files = [x for x in os.listdir(".") if x.endswith(".version.txt")] +for version_file in version_files: -# Search each file using its regex -for k, v in regexes.items(): - try: - with open(v[0]) as x: - versions = x.read() - match = re.search(v[1], versions) - if match: - results[k] = "v{}".format(match.group(1)) - except IOError: - results[k] = False + software = version_file.replace(".version.txt", "") + if software == "pipeline": + software = "nf-core/chipseq" -# Remove software set to false in results -for k in list(results): - if not results[k]: - del results[k] + with open(version_file) as fin: + version = fin.read().strip() + results[software] = version # Dump to YAML print( @@ -44,11 +26,11 @@
""" ) -for k, v in results.items(): +for k, v in sorted(results.items()): print("
{}
{}
".format(k, v)) print("
") # Write out regexes as csv file: -with open("software_versions.csv", "w") as f: - for k, v in results.items(): +with open("software_versions.tsv", "w") as f: + for k, v in sorted(results.items()): f.write("{}\t{}\n".format(k, v)) diff --git a/conf/base.config b/conf/base.config index 41dac7b60..467dd2fed 100644 --- a/conf/base.config +++ b/conf/base.config @@ -1,51 +1,57 @@ /* - * ------------------------------------------------- - * nf-core/chipseq Nextflow base config file - * ------------------------------------------------- - * A 'blank slate' config file, appropriate for general - * use on most high performace compute environments. - * Assumes that all software is installed and available - * on the PATH. Runs in `local` mode - all jobs will be - * run on the logged in environment. - */ +======================================================================================== + nf-core/chipseq Nextflow base config file +======================================================================================== + A 'blank slate' config file, appropriate for general use on most high performance + compute environments. Assumes that all software is installed and available on + the PATH. Runs in `local` mode - all jobs will be run on the logged in environment. +---------------------------------------------------------------------------------------- +*/ process { - // TODO nf-core: Check the defaults for all processes - cpus = { check_max( 1 * task.attempt, 'cpus' ) } - memory = { check_max( 7.GB * task.attempt, 'memory' ) } - time = { check_max( 4.h * task.attempt, 'time' ) } + // TODO nf-core: Check the defaults for all processes + cpus = { check_max( 1 * task.attempt, 'cpus' ) } + memory = { check_max( 6.GB * task.attempt, 'memory' ) } + time = { check_max( 4.h * task.attempt, 'time' ) } - errorStrategy = { task.exitStatus in [143,137,104,134,139] ? 'retry' : 'finish' } - maxRetries = 1 - maxErrors = '-1' - - // Process-specific resource requirements - // NOTE - Only one of the labels below are used in the fastqc process in the main script. - // If possible, it would be nice to keep the same label naming convention when - // adding in your processes. - // TODO nf-core: Customise requirements for specific processes. - // See https://www.nextflow.io/docs/latest/config.html#config-process-selectors - withLabel:process_low { - cpus = { check_max( 2 * task.attempt, 'cpus' ) } - memory = { check_max( 14.GB * task.attempt, 'memory' ) } - time = { check_max( 6.h * task.attempt, 'time' ) } - } - withLabel:process_medium { - cpus = { check_max( 6 * task.attempt, 'cpus' ) } - memory = { check_max( 42.GB * task.attempt, 'memory' ) } - time = { check_max( 8.h * task.attempt, 'time' ) } - } - withLabel:process_high { - cpus = { check_max( 12 * task.attempt, 'cpus' ) } - memory = { check_max( 84.GB * task.attempt, 'memory' ) } - time = { check_max( 10.h * task.attempt, 'time' ) } - } - withLabel:process_long { - time = { check_max( 20.h * task.attempt, 'time' ) } - } - withName:get_software_versions { - cache = false - } + errorStrategy = { task.exitStatus in [143,137,104,134,139] ? 'retry' : 'finish' } + maxRetries = 1 + maxErrors = '-1' + // Process-specific resource requirements + // NOTE - Please try and re-use the labels below as much as possible. + // These labels are used and recognised by default in DSL2 files hosted on nf-core/modules. + // If possible, it would be nice to keep the same label naming convention when + // adding in your local modules too. + // TODO nf-core: Customise requirements for specific processes. + // See https://www.nextflow.io/docs/latest/config.html#config-process-selectors + withLabel:process_low { + cpus = { check_max( 2 * task.attempt, 'cpus' ) } + memory = { check_max( 12.GB * task.attempt, 'memory' ) } + time = { check_max( 4.h * task.attempt, 'time' ) } + } + withLabel:process_medium { + cpus = { check_max( 6 * task.attempt, 'cpus' ) } + memory = { check_max( 36.GB * task.attempt, 'memory' ) } + time = { check_max( 8.h * task.attempt, 'time' ) } + } + withLabel:process_high { + cpus = { check_max( 12 * task.attempt, 'cpus' ) } + memory = { check_max( 72.GB * task.attempt, 'memory' ) } + time = { check_max( 16.h * task.attempt, 'time' ) } + } + withLabel:process_long { + time = { check_max( 20.h * task.attempt, 'time' ) } + } + withLabel:process_high_memory { + memory = { check_max( 200.GB * task.attempt, 'memory' ) } + } + withLabel:error_ignore { + errorStrategy = 'ignore' + } + withLabel:error_retry { + errorStrategy = 'retry' + maxRetries = 2 + } } diff --git a/conf/igenomes.config b/conf/igenomes.config index 31b7ee613..855948def 100644 --- a/conf/igenomes.config +++ b/conf/igenomes.config @@ -1,421 +1,432 @@ /* - * ------------------------------------------------- - * Nextflow config file for iGenomes paths - * ------------------------------------------------- - * Defines reference genomes, using iGenome paths - * Can be used by any config that customises the base - * path using $params.igenomes_base / --igenomes_base - */ +======================================================================================== + Nextflow config file for iGenomes paths +======================================================================================== + Defines reference genomes using iGenome paths. + Can be used by any config that customises the base path using: + $params.igenomes_base / --igenomes_base +---------------------------------------------------------------------------------------- +*/ params { - // illumina iGenomes reference file paths - genomes { - 'GRCh37' { - fasta = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/README.txt" - mito_name = "MT" - macs_gsize = "2.7e9" - blacklist = "${projectDir}/assets/blacklists/GRCh37-blacklist.bed" + // illumina iGenomes reference file paths + genomes { + 'GRCh37' { + fasta = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/README.txt" + mito_name = "MT" + macs_gsize = "2.7e9" + blacklist = "${projectDir}/assets/blacklists/GRCh37-blacklist.bed" + } + 'GRCh38' { + fasta = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Annotation/Genes/genes.bed" + mito_name = "chrM" + macs_gsize = "2.7e9" + blacklist = "${projectDir}/assets/blacklists/hg38-blacklist.bed" + } + 'GRCm38' { + fasta = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/README.txt" + mito_name = "MT" + macs_gsize = "1.87e9" + blacklist = "${projectDir}/assets/blacklists/GRCm38-blacklist.bed" + } + 'TAIR10' { + fasta = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/README.txt" + mito_name = "Mt" + } + 'EB2' { + fasta = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/README.txt" + } + 'UMD3.1' { + fasta = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/README.txt" + mito_name = "MT" + } + 'WBcel235' { + fasta = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Annotation/Genes/genes.bed" + mito_name = "MtDNA" + macs_gsize = "9e7" + } + 'CanFam3.1' { + fasta = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/README.txt" + mito_name = "MT" + } + 'GRCz10' { + fasta = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Annotation/Genes/genes.bed" + mito_name = "MT" + } + 'BDGP6' { + fasta = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Annotation/Genes/genes.bed" + mito_name = "M" + macs_gsize = "1.2e8" + } + 'EquCab2' { + fasta = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/README.txt" + mito_name = "MT" + } + 'EB1' { + fasta = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/README.txt" + } + 'Galgal4' { + fasta = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Annotation/Genes/genes.bed" + mito_name = "MT" + } + 'Gm01' { + fasta = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/README.txt" + } + 'Mmul_1' { + fasta = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/README.txt" + mito_name = "MT" + } + 'IRGSP-1.0' { + fasta = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Annotation/Genes/genes.bed" + mito_name = "Mt" + } + 'CHIMP2.1.4' { + fasta = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/README.txt" + mito_name = "MT" + } + 'Rnor_5.0' { + fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Annotation/Genes/genes.bed" + mito_name = "MT" + } + 'Rnor_6.0' { + fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Annotation/Genes/genes.bed" + mito_name = "MT" + } + 'R64-1-1' { + fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Annotation/Genes/genes.bed" + mito_name = "MT" + macs_gsize = "1.2e7" + } + 'EF2' { + fasta = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/README.txt" + mito_name = "MT" + macs_gsize = "1.21e7" + } + 'Sbi1' { + fasta = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/README.txt" + } + 'Sscrofa10.2' { + fasta = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/README.txt" + mito_name = "MT" + } + 'AGPv3' { + fasta = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Annotation/Genes/genes.bed" + mito_name = "Mt" + } + 'hg38' { + fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Annotation/Genes/genes.bed" + mito_name = "chrM" + macs_gsize = "2.7e9" + blacklist = "${projectDir}/assets/blacklists/hg38-blacklist.bed" + } + 'hg19' { + fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/README.txt" + mito_name = "chrM" + macs_gsize = "2.7e9" + blacklist = "${projectDir}/assets/blacklists/hg19-blacklist.bed" + } + 'mm10' { + fasta = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/README.txt" + mito_name = "chrM" + macs_gsize = "1.87e9" + blacklist = "${projectDir}/assets/blacklists/mm10-blacklist.bed" + } + 'bosTau8' { + fasta = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Annotation/Genes/genes.bed" + mito_name = "chrM" + } + 'ce10' { + fasta = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/README.txt" + mito_name = "chrM" + macs_gsize = "9e7" + } + 'canFam3' { + fasta = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/README.txt" + mito_name = "chrM" + } + 'danRer10' { + fasta = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.bed" + mito_name = "chrM" + macs_gsize = "1.37e9" + } + 'dm6' { + fasta = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Annotation/Genes/genes.bed" + mito_name = "chrM" + macs_gsize = "1.2e8" + } + 'equCab2' { + fasta = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/README.txt" + mito_name = "chrM" + } + 'galGal4' { + fasta = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/README.txt" + mito_name = "chrM" + } + 'panTro4' { + fasta = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/README.txt" + mito_name = "chrM" + } + 'rn6' { + fasta = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Annotation/Genes/genes.bed" + mito_name = "chrM" + } + 'sacCer3' { + fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BismarkIndex/" + readme = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Annotation/README.txt" + mito_name = "chrM" + macs_gsize = "1.2e7" + } + 'susScr3' { + fasta = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/README.txt" + mito_name = "chrM" + } } - 'GRCh38' { - fasta = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Annotation/Genes/genes.bed" - mito_name = "chrM" - macs_gsize = "2.7e9" - blacklist = "${projectDir}/assets/blacklists/hg38-blacklist.bed" - } - 'GRCm38' { - fasta = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/README.txt" - mito_name = "MT" - macs_gsize = "1.87e9" - blacklist = "${projectDir}/assets/blacklists/GRCm38-blacklist.bed" - } - 'TAIR10' { - fasta = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/README.txt" - mito_name = "Mt" - } - 'EB2' { - fasta = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/README.txt" - } - 'UMD3.1' { - fasta = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/README.txt" - mito_name = "MT" - } - 'WBcel235' { - fasta = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Annotation/Genes/genes.bed" - mito_name = "MtDNA" - macs_gsize = "9e7" - } - 'CanFam3.1' { - fasta = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/README.txt" - mito_name = "MT" - } - 'GRCz10' { - fasta = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Annotation/Genes/genes.bed" - mito_name = "MT" - } - 'BDGP6' { - fasta = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Annotation/Genes/genes.bed" - mito_name = "M" - macs_gsize = "1.2e8" - } - 'EquCab2' { - fasta = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/README.txt" - mito_name = "MT" - } - 'EB1' { - fasta = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/README.txt" - } - 'Galgal4' { - fasta = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Annotation/Genes/genes.bed" - mito_name = "MT" - } - 'Gm01' { - fasta = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/README.txt" - } - 'Mmul_1' { - fasta = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/README.txt" - mito_name = "MT" - } - 'IRGSP-1.0' { - fasta = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Annotation/Genes/genes.bed" - mito_name = "Mt" - } - 'CHIMP2.1.4' { - fasta = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/README.txt" - mito_name = "MT" - } - 'Rnor_6.0' { - fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Annotation/Genes/genes.bed" - mito_name = "MT" - } - 'R64-1-1' { - fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Annotation/Genes/genes.bed" - mito_name = "MT" - macs_gsize = "1.2e7" - } - 'EF2' { - fasta = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/README.txt" - mito_name = "MT" - macs_gsize = "1.21e7" - } - 'Sbi1' { - fasta = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/README.txt" - } - 'Sscrofa10.2' { - fasta = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/README.txt" - mito_name = "MT" - } - 'AGPv3' { - fasta = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Annotation/Genes/genes.bed" - mito_name = "Mt" - } - 'hg38' { - fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Annotation/Genes/genes.bed" - mito_name = "chrM" - macs_gsize = "2.7e9" - blacklist = "${projectDir}/assets/blacklists/hg38-blacklist.bed" - } - 'hg19' { - fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/README.txt" - mito_name = "chrM" - macs_gsize = "2.7e9" - blacklist = "${projectDir}/assets/blacklists/hg19-blacklist.bed" - } - 'mm10' { - fasta = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/README.txt" - mito_name = "chrM" - macs_gsize = "1.87e9" - blacklist = "${projectDir}/assets/blacklists/mm10-blacklist.bed" - } - 'bosTau8' { - fasta = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Annotation/Genes/genes.bed" - mito_name = "chrM" - } - 'ce10' { - fasta = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/README.txt" - mito_name = "chrM" - macs_gsize = "9e7" - } - 'canFam3' { - fasta = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/README.txt" - mito_name = "chrM" - } - 'danRer10' { - fasta = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.bed" - mito_name = "chrM" - macs_gsize = "1.37e9" - } - 'dm6' { - fasta = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Annotation/Genes/genes.bed" - mito_name = "chrM" - macs_gsize = "1.2e8" - } - 'equCab2' { - fasta = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/README.txt" - mito_name = "chrM" - } - 'galGal4' { - fasta = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/README.txt" - mito_name = "chrM" - } - 'panTro4' { - fasta = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/README.txt" - mito_name = "chrM" - } - 'rn6' { - fasta = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Annotation/Genes/genes.bed" - mito_name = "chrM" - } - 'sacCer3' { - fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BismarkIndex/" - readme = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Annotation/README.txt" - mito_name = "chrM" - macs_gsize = "1.2e7" - } - 'susScr3' { - fasta = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BWAIndex/genome.fa" - bowtie2 = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/Bowtie2Index/" - star = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/README.txt" - mito_name = "chrM" - } - } } diff --git a/conf/modules.config b/conf/modules.config new file mode 100644 index 000000000..0b1bfdec2 --- /dev/null +++ b/conf/modules.config @@ -0,0 +1,32 @@ +/* +======================================================================================== + Config file for defining DSL2 per module options +======================================================================================== + Available keys to override module options: + args = Additional arguments appended to command in module. + args2 = Second set of arguments appended to command in module (multi-tool modules). + args3 = Third set of arguments appended to command in module (multi-tool modules). + publish_dir = Directory to publish results. + publish_by_meta = Groovy list of keys available in meta map to append as directories to "publish_dir" path + If publish_by_meta = true - Value of ${meta['id']} is appended as a directory to "publish_dir" path + If publish_by_meta = ['id', 'custompath'] - If "id" is in meta map and "custompath" isn't then "${meta['id']}/custompath/" + is appended as a directory to "publish_dir" path + If publish_by_meta = false / null - No directories are appended to "publish_dir" path + publish_files = Groovy map where key = "file_ext" and value = "directory" to publish results for that file extension + The value of "directory" is appended to the standard "publish_dir" path as defined above. + If publish_files = null (unspecified) - All files are published. + If publish_files = false - No files are published. + suffix = File name suffix for output files. +---------------------------------------------------------------------------------------- +*/ + +params { + modules { + 'fastqc' { + args = "--quiet" + } + 'multiqc' { + args = "" + } + } +} diff --git a/conf/test.config b/conf/test.config index 3f958b4a6..cc60ec23e 100644 --- a/conf/test.config +++ b/conf/test.config @@ -1,28 +1,29 @@ /* - * ------------------------------------------------- - * Nextflow config file for running tests - * ------------------------------------------------- - * Defines bundled input files and everything required - * to run a fast and simple test. Use as follows: - * nextflow run nf-core/chipseq -profile test, - */ +======================================================================================== + Nextflow config file for running minimal tests +======================================================================================== + Defines input files and everything required to run a fast and simple pipeline test. + + Use as follows: + nextflow run nf-core/chipseq -profile test, + +---------------------------------------------------------------------------------------- +*/ params { - config_profile_name = 'Test profile' - config_profile_description = 'Minimal test dataset to check pipeline function' - // Limit resources so that this can run on GitHub Actions - max_cpus = 2 - max_memory = 6.GB - max_time = 48.h + config_profile_name = 'Test profile' + config_profile_description = 'Minimal test dataset to check pipeline function' + + // Limit resources so that this can run on GitHub Actions + max_cpus = 2 + max_memory = 6.GB + max_time = 6.h + + // Input data + // TODO nf-core: Specify the paths to your test data on nf-core/test-datasets + // TODO nf-core: Give any required params for the test so that command line flags are not needed + input = 'https://raw.githubusercontent.com/nf-core/test-datasets/viralrecon/samplesheet/samplesheet_test_illumina_amplicon.csv' - // Input data - // TODO nf-core: Specify the paths to your test data on nf-core/test-datasets - // TODO nf-core: Give any required params for the test so that command line flags are not needed - single_end = false - input_paths = [ - ['Testdata', ['https://github.com/nf-core/test-datasets/raw/exoseq/testdata/Testdata_R1.tiny.fastq.gz', 'https://github.com/nf-core/test-datasets/raw/exoseq/testdata/Testdata_R2.tiny.fastq.gz']], - ['SRR389222', ['https://github.com/nf-core/test-datasets/raw/methylseq/testdata/SRR389222_sub1.fastq.gz', 'https://github.com/nf-core/test-datasets/raw/methylseq/testdata/SRR389222_sub2.fastq.gz']] - ] - // Ignore `--input` as otherwise the parameter validation will throw an error - schema_ignore_params = 'genomes,input_paths,input' + // Genome references + genome = 'R64-1-1' } diff --git a/conf/test_full.config b/conf/test_full.config index 818118452..d8fe4234c 100644 --- a/conf/test_full.config +++ b/conf/test_full.config @@ -1,24 +1,24 @@ /* - * ------------------------------------------------- - * Nextflow config file for running full-size tests - * ------------------------------------------------- - * Defines bundled input files and everything required - * to run a full size pipeline test. Use as follows: - * nextflow run nf-core/chipseq -profile test_full, - */ +======================================================================================== + Nextflow config file for running full-size tests +======================================================================================== + Defines input files and everything required to run a full size pipeline test. + + Use as follows: + nextflow run nf-core/chipseq -profile test_full, + +---------------------------------------------------------------------------------------- +*/ params { - config_profile_name = 'Full test profile' - config_profile_description = 'Full test dataset to check pipeline function' + config_profile_name = 'Full test profile' + config_profile_description = 'Full test dataset to check pipeline function' + + // Input data for full size test + // TODO nf-core: Specify the paths to your full test data ( on nf-core/test-datasets or directly in repositories, e.g. SRA) + // TODO nf-core: Give any required params for the test so that command line flags are not needed + input = 'https://raw.githubusercontent.com/nf-core/test-datasets/viralrecon/samplesheet/samplesheet_full_illumina_amplicon.csv' - // Input data for full size test - // TODO nf-core: Specify the paths to your full test data ( on nf-core/test-datasets or directly in repositories, e.g. SRA) - // TODO nf-core: Give any required params for the test so that command line flags are not needed - single_end = false - input_paths = [ - ['Testdata', ['https://github.com/nf-core/test-datasets/raw/exoseq/testdata/Testdata_R1.tiny.fastq.gz', 'https://github.com/nf-core/test-datasets/raw/exoseq/testdata/Testdata_R2.tiny.fastq.gz']], - ['SRR389222', ['https://github.com/nf-core/test-datasets/raw/methylseq/testdata/SRR389222_sub1.fastq.gz', 'https://github.com/nf-core/test-datasets/raw/methylseq/testdata/SRR389222_sub2.fastq.gz']] - ] - // Ignore `--input` as otherwise the parameter validation will throw an error - schema_ignore_params = 'genomes,input_paths,input' + // Genome references + genome = 'R64-1-1' } diff --git a/docs/README.md b/docs/README.md index 68b828949..ac8a8b69c 100644 --- a/docs/README.md +++ b/docs/README.md @@ -3,8 +3,8 @@ The nf-core/chipseq documentation is split into the following pages: * [Usage](usage.md) - * An overview of how the pipeline works, how to run it and a description of all of the different command-line flags. + * An overview of how the pipeline works, how to run it and a description of all of the different command-line flags. * [Output](output.md) - * An overview of the different results produced by the pipeline and how to interpret them. + * An overview of the different results produced by the pipeline and how to interpret them. You can find a lot more documentation about installing, configuring and running nf-core pipelines on the website: [https://nf-co.re](https://nf-co.re) diff --git a/docs/images/mqc_fastqc_adapter.png b/docs/images/mqc_fastqc_adapter.png new file mode 100755 index 0000000000000000000000000000000000000000..361d0e47acfb424dea1f326590d1eb2f6dfa26b5 GIT binary patch literal 23458 zcmeFZ2UJtryD!S#x<#o93es(Ww4k)maRbte0-+a?-g^xY-3myTE`8G_KvA54)F1tn})nJ5u%TA4Y;^!^{48eL_}p#q-Umo0M|F1 z74+PQh^X8N|9_jcWbq~ zzn+tZC9B75nKdz=gQ8wo9GJ$P{D~3knlI_`-PRhCw34f1oYDLr^;oEbgxa#A^J%*2 z>FfDE*(~JzKFs$t_oeLz))qDU?s}%Q?7b~3Y;lUi^Oy-2@3g?joA4Wkgb6-2=ih*jub)~7yZ`T=L=Z`B`{1jhkB-iSjea94&Eo9A zxN59pv1p_}RO1>EC^q}Z2)ZI;b7JV_x4lMr=Bker2+EK;8~!;JO7re*@ZkDmoV878S*N^yX(F@U1yqt?Is3nnV>7}#(5pk`V3C) zWhB8;CwWIwsVIjH+`<9=YA(j&3DgQdFOOGU~*`36wNC&QDv8> zr?h2PQgnHkp&t^S)q^K!68h~`$PjZW&-Wns;Zlw$M2sc z1xR!u{m|Kih*|Hht#M@eOMM#8O*={^6b9k5B5^eBsrnhVHD7XZ5BWO&F?q(>Y=QFl z`f>yQ9NCoxZCH-1F{#mz_j{QeyY~4h*VeyYZ#S@Z(Pnb7G=ud!RW)5svqM*&GI_za 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the following steps: +The pipeline is built using [Nextflow](https://www.nextflow.io/) and processes data using the following steps: -* [FastQC](#fastqc) - Read quality control -* [MultiQC](#multiqc) - Aggregate report describing results from the whole pipeline +* [FastQC](#fastqc) - Raw read QC +* [MultiQC](#multiqc) - Aggregate report describing results and QC from the whole pipeline * [Pipeline information](#pipeline-information) - Report metrics generated during the workflow execution -## FastQC +### FastQC -[FastQC](http://www.bioinformatics.babraham.ac.uk/projects/fastqc/) gives general quality metrics about your sequenced reads. It provides information about the quality score distribution across your reads, per base sequence content (%A/T/G/C), adapter contamination and overrepresented sequences. +
+Output files -For further reading and documentation see the [FastQC help pages](http://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/). +* `fastqc/` + * `*_fastqc.html`: FastQC report containing quality metrics. + * `*_fastqc.zip`: Zip archive containing the FastQC report, tab-delimited data file and plot images. -**Output files:** +
-* `fastqc/` - * `*_fastqc.html`: FastQC report containing quality metrics for your untrimmed raw fastq files. -* `fastqc/zips/` - * `*_fastqc.zip`: Zip archive containing the FastQC report, tab-delimited data file and plot images. +[FastQC](http://www.bioinformatics.babraham.ac.uk/projects/fastqc/) gives general quality metrics about your sequenced reads. It provides information about the quality score distribution across your reads, per base sequence content (%A/T/G/C), adapter contamination and overrepresented sequences. For further reading and documentation see the [FastQC help pages](http://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/). -> **NB:** The FastQC plots displayed in the MultiQC report shows _untrimmed_ reads. They may contain adapter sequence and potentially regions with low quality. +![MultiQC - FastQC sequence counts plot](images/mqc_fastqc_counts.png) -## MultiQC +![MultiQC - FastQC mean quality scores plot](images/mqc_fastqc_quality.png) -[MultiQC](http://multiqc.info) is a visualization tool that generates a single HTML report summarizing all samples in your project. Most of the pipeline QC results are visualised in the report and further statistics are available in the report data directory. +![MultiQC - FastQC adapter content plot](images/mqc_fastqc_adapter.png) -The pipeline has special steps which also allow the software versions to be reported in the MultiQC output for future traceability. +> **NB:** The FastQC plots displayed in the MultiQC report shows _untrimmed_ reads. They may contain adapter sequence and potentially regions with low quality. -For more information about how to use MultiQC reports, see [https://multiqc.info](https://multiqc.info). +### MultiQC -**Output files:** +
+Output files * `multiqc/` - * `multiqc_report.html`: a standalone HTML file that can be viewed in your web browser. - * `multiqc_data/`: directory containing parsed statistics from the different tools used in the pipeline. - * `multiqc_plots/`: directory containing static images from the report in various formats. + * `multiqc_report.html`: a standalone HTML file that can be viewed in your web browser. + * `multiqc_data/`: directory containing parsed statistics from the different tools used in the pipeline. + * `multiqc_plots/`: directory containing static images from the report in various formats. -## Pipeline information +
-[Nextflow](https://www.nextflow.io/docs/latest/tracing.html) provides excellent functionality for generating various reports relevant to the running and execution of the pipeline. This will allow you to troubleshoot errors with the running of the pipeline, and also provide you with other information such as launch commands, run times and resource usage. +[MultiQC](http://multiqc.info) is a visualization tool that generates a single HTML report summarising all samples in your project. Most of the pipeline QC results are visualised in the report and further statistics are available in the report data directory. -**Output files:** +Results generated by MultiQC collate pipeline QC from supported tools e.g. FastQC. The pipeline has special steps which also allow the software versions to be reported in the MultiQC output for future traceability. For more information about how to use MultiQC reports, see . + +### Pipeline information + +
+Output files * `pipeline_info/` - * Reports generated by Nextflow: `execution_report.html`, `execution_timeline.html`, `execution_trace.txt` and `pipeline_dag.dot`/`pipeline_dag.svg`. - * Reports generated by the pipeline: `pipeline_report.html`, `pipeline_report.txt` and `software_versions.csv`. - * Documentation for interpretation of results in HTML format: `results_description.html`. + * Reports generated by Nextflow: `execution_report.html`, `execution_timeline.html`, `execution_trace.txt` and `pipeline_dag.dot`/`pipeline_dag.svg`. + * Reports generated by the pipeline: `pipeline_report.html`, `pipeline_report.txt` and `software_versions.tsv`. + * Reformatted samplesheet files used as input to the pipeline: `samplesheet.valid.csv`. + +
+ +[Nextflow](https://www.nextflow.io/docs/latest/tracing.html) provides excellent functionality for generating various reports relevant to the running and execution of the pipeline. This will allow you to troubleshoot errors with the running of the pipeline, and also provide you with other information such as launch commands, run times and resource usage. diff --git a/docs/usage.md b/docs/usage.md index 1040afb1f..49bda59c7 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -8,19 +8,63 @@ +## Samplesheet input + +You will need to create a samplesheet with information about the samples you would like to analyse before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 3 columns, and a header row as shown in the examples below. + +```console +--input '[path to samplesheet file]' +``` + +### Multiple runs of the same sample + +The `sample` identifiers have to be the same when you have re-sequenced the same sample more than once e.g. to increase sequencing depth. The pipeline will concatenate the raw reads before performing any downstream analysis. Below is an example for the same sample sequenced across 3 lanes: + +```console +sample,fastq_1,fastq_2 +CONTROL_REP1,AEG588A1_S1_L002_R1_001.fastq.gz,AEG588A1_S1_L002_R2_001.fastq.gz +CONTROL_REP1,AEG588A1_S1_L003_R1_001.fastq.gz,AEG588A1_S1_L003_R2_001.fastq.gz +CONTROL_REP1,AEG588A1_S1_L004_R1_001.fastq.gz,AEG588A1_S1_L004_R2_001.fastq.gz +``` + +### Full samplesheet + +The pipeline will auto-detect whether a sample is single- or paired-end using the information provided in the samplesheet. The samplesheet can have as many columns as you desire, however, there is a strict requirement for the first 3 columns to match those defined in the table below. + +A final samplesheet file consisting of both single- and paired-end data may look something like the one below. This is for 6 samples, where `TREATMENT_REP3` has been sequenced twice. + +```console +sample,fastq_1,fastq_2 +CONTROL_REP1,AEG588A1_S1_L002_R1_001.fastq.gz,AEG588A1_S1_L002_R2_001.fastq.gz +CONTROL_REP2,AEG588A2_S2_L002_R1_001.fastq.gz,AEG588A2_S2_L002_R2_001.fastq.gz +CONTROL_REP3,AEG588A3_S3_L002_R1_001.fastq.gz,AEG588A3_S3_L002_R2_001.fastq.gz +TREATMENT_REP1,AEG588A4_S4_L003_R1_001.fastq.gz, +TREATMENT_REP2,AEG588A5_S5_L003_R1_001.fastq.gz, +TREATMENT_REP3,AEG588A6_S6_L003_R1_001.fastq.gz, +TREATMENT_REP3,AEG588A6_S6_L004_R1_001.fastq.gz, +``` + +| Column | Description | +|----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------| +| `sample` | Custom sample name. This entry will be identical for multiple sequencing libraries/runs from the same sample. Spaces in sample names are automatically converted to underscores (`_`). | +| `fastq_1` | Full path to FastQ file for Illumina short reads 1. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | +| `fastq_2` | Full path to FastQ file for Illumina short reads 2. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | + +An [example samplesheet](../assets/samplesheet.csv) has been provided with the pipeline. + ## Running the pipeline The typical command for running the pipeline is as follows: -```bash -nextflow run nf-core/chipseq --input '*_R{1,2}.fastq.gz' -profile docker +```console +nextflow run nf-core/chipseq --input samplesheet.csv --genome GRCh37 -profile docker ``` This will launch the pipeline with the `docker` configuration profile. See below for more information about profiles. Note that the pipeline will create the following files in your working directory: -```bash +```console work # Directory containing the nextflow working files results # Finished results (configurable, see below) .nextflow_log # Log file from Nextflow @@ -31,13 +75,13 @@ results # Finished results (configurable, see below) When you run the above command, Nextflow automatically pulls the pipeline code from GitHub and stores it as a cached version. When running the pipeline after this, it will always use the cached version if available - even if the pipeline has been updated since. To make sure that you're running the latest version of the pipeline, make sure that you regularly update the cached version of the pipeline: -```bash +```console nextflow pull nf-core/chipseq ``` ### Reproducibility -It's a good idea to specify a pipeline version when running the pipeline on your data. This ensures that a specific version of the pipeline code and software are used when you run your pipeline. If you keep using the same tag, you'll be running the same version of the pipeline, even if there have been changes to the code since. +It is a good idea to specify a pipeline version when running the pipeline on your data. This ensures that a specific version of the pipeline code and software are used when you run your pipeline. If you keep using the same tag, you'll be running the same version of the pipeline, even if there have been changes to the code since. First, go to the [nf-core/chipseq releases page](https://github.com/nf-core/chipseq/releases) and find the latest version number - numeric only (eg. `1.3.1`). Then specify this when running the pipeline with `-r` (one hyphen) - eg. `-r 1.3.1`. @@ -51,7 +95,7 @@ This version number will be logged in reports when you run the pipeline, so that Use this parameter to choose a configuration profile. Profiles can give configuration presets for different compute environments. -Several generic profiles are bundled with the pipeline which instruct the pipeline to use software packaged using different methods (Docker, Singularity, Podman, Shifter, Charliecloud, Conda) - see below. +Several generic profiles are bundled with the pipeline which instruct the pipeline to use software packaged using different methods (Docker, Singularity, Podman, Shifter, Charliecloud, Conda) - see below. When using Biocontainers, most of these software packaging methods pull Docker containers from quay.io e.g [FastQC](https://quay.io/repository/biocontainers/fastqc) except for Singularity which directly downloads Singularity images via https hosted by the [Galaxy project](https://depot.galaxyproject.org/singularity/) and Conda which downloads and installs software locally from [Bioconda](https://bioconda.github.io/). > We highly recommend the use of Docker or Singularity containers for full pipeline reproducibility, however when this is not possible, Conda is also supported. @@ -63,27 +107,20 @@ They are loaded in sequence, so later profiles can overwrite earlier profiles. If `-profile` is not specified, the pipeline will run locally and expect all software to be installed and available on the `PATH`. This is _not_ recommended. * `docker` - * A generic configuration profile to be used with [Docker](https://docker.com/) - * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Docker](https://docker.com/) * `singularity` - * A generic configuration profile to be used with [Singularity](https://sylabs.io/docs/) - * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Singularity](https://sylabs.io/docs/) * `podman` - * A generic configuration profile to be used with [Podman](https://podman.io/) - * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Podman](https://podman.io/) * `shifter` - * A generic configuration profile to be used with [Shifter](https://nersc.gitlab.io/development/shifter/how-to-use/) - * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Shifter](https://nersc.gitlab.io/development/shifter/how-to-use/) * `charliecloud` - * A generic configuration profile to be used with [Charliecloud](https://hpc.github.io/charliecloud/) - * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Charliecloud](https://hpc.github.io/charliecloud/) * `conda` - * Please only use Conda as a last resort i.e. when it's not possible to run the pipeline with Docker, Singularity, Podman, Shifter or Charliecloud. - * A generic configuration profile to be used with [Conda](https://conda.io/docs/) - * Pulls most software from [Bioconda](https://bioconda.github.io/) + * A generic configuration profile to be used with [Conda](https://conda.io/docs/). Please only use Conda as a last resort i.e. when it's not possible to run the pipeline with Docker, Singularity, Podman, Shifter or Charliecloud. * `test` - * A profile with a complete configuration for automated testing - * Includes links to test data so needs no other parameters + * A profile with a complete configuration for automated testing + * Includes links to test data so needs no other parameters ### `-resume` @@ -95,29 +132,140 @@ You can also supply a run name to resume a specific run: `-resume [run-name]`. U Specify the path to a specific config file (this is a core Nextflow command). See the [nf-core website documentation](https://nf-co.re/usage/configuration) for more information. -#### Custom resource requests +## Custom configuration + +### Resource requests + +Whilst the default requirements set within the pipeline will hopefully work for most people and with most input data, you may find that you want to customise the compute resources that the pipeline requests. Each step in the pipeline has a default set of requirements for number of CPUs, memory and time. For most of the steps in the pipeline, if the job exits with any of the error codes specified [here](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/base.config#L18) it will automatically be resubmitted with higher requests (2 x original, then 3 x original). If it still fails after the third attempt then the pipeline execution is stopped. + +For example, if the nf-core/rnaseq pipeline is failing after multiple re-submissions of the `STAR_ALIGN` process due to an exit code of `137` this would indicate that there is an out of memory issue: + +```console +[62/149eb0] NOTE: Process `RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)` terminated with an error exit status (137) -- Execution is retried (1) +Error executing process > 'RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)' + +Caused by: + Process `RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)` terminated with an error exit status (137) -Each step in the pipeline has a default set of requirements for number of CPUs, memory and time. For most of the steps in the pipeline, if the job exits with an error code of `143` (exceeded requested resources) it will automatically resubmit with higher requests (2 x original, then 3 x original). If it still fails after three times then the pipeline is stopped. +Command executed: + STAR \ + --genomeDir star \ + --readFilesIn WT_REP1_trimmed.fq.gz \ + --runThreadN 2 \ + --outFileNamePrefix WT_REP1. \ + -Whilst these default requirements will hopefully work for most people with most data, you may find that you want to customise the compute resources that the pipeline requests. You can do this by creating a custom config file. For example, to give the workflow process `star` 32GB of memory, you could use the following config: +Command exit status: + 137 + +Command output: + (empty) + +Command error: + .command.sh: line 9: 30 Killed STAR --genomeDir star --readFilesIn WT_REP1_trimmed.fq.gz --runThreadN 2 --outFileNamePrefix WT_REP1. +Work dir: + /home/pipelinetest/work/9d/172ca5881234073e8d76f2a19c88fb + +Tip: you can replicate the issue by changing to the process work dir and entering the command `bash .command.run` +``` + +To bypass this error you would need to find exactly which resources are set by the `STAR_ALIGN` process. The quickest way is to search for `process STAR_ALIGN` in the [nf-core/rnaseq Github repo](https://github.com/nf-core/rnaseq/search?q=process+STAR_ALIGN). We have standardised the structure of Nextflow DSL2 pipelines such that all module files will be present in the `modules/` directory and so based on the search results the file we want is `modules/nf-core/software/star/align/main.nf`. If you click on the link to that file you will notice that there is a `label` directive at the top of the module that is set to [`label process_high`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/modules/nf-core/software/star/align/main.nf#L9). The [Nextflow `label`](https://www.nextflow.io/docs/latest/process.html#label) directive allows us to organise workflow processes in separate groups which can be referenced in a configuration file to select and configure subset of processes having similar computing requirements. The default values for the `process_high` label are set in the pipeline's [`base.config`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/base.config#L33-L37) which in this case is defined as 72GB. Providing you haven't set any other standard nf-core parameters to __cap__ the [maximum resources](https://nf-co.re/usage/configuration#max-resources) used by the pipeline then we can try and bypass the `STAR_ALIGN` process failure by creating a custom config file that sets at least 72GB of memory, in this case increased to 100GB. The custom config below can then be provided to the pipeline via the [`-c`](#-c) parameter as highlighted in previous sections. ```nextflow process { - withName: star { - memory = 32.GB - } + withName: STAR_ALIGN { + memory = 100.GB + } } ``` -To find the exact name of a process you wish to modify the compute resources, check the live-status of a nextflow run displayed on your terminal or check the nextflow error for a line like so: `Error executing process > 'bwa'`. In this case the name to specify in the custom config file is `bwa`. +> **NB:** We specify just the process name i.e. `STAR_ALIGN` in the config file and not the full task name string that is printed to screen in the error message or on the terminal whilst the pipeline is running i.e. `RNASEQ:ALIGN_STAR:STAR_ALIGN`. You may get a warning suggesting that the process selector isn't recognised but you can ignore that if the process name has been specified correctly. This is something that needs to be fixed upstream in core Nextflow. + +### Tool-specific options + +For the ultimate flexibility, we have implemented and are using Nextflow DSL2 modules in a way where it is possible for both developers and users to change tool-specific command-line arguments (e.g. providing an additional command-line argument to the `STAR_ALIGN` process) as well as publishing options (e.g. saving files produced by the `STAR_ALIGN` process that aren't saved by default by the pipeline). In the majority of instances, as a user you won't have to change the default options set by the pipeline developer(s), however, there may be edge cases where creating a simple custom config file can improve the behaviour of the pipeline if for example it is failing due to a weird error that requires setting a tool-specific parameter to deal with smaller / larger genomes. + +The command-line arguments passed to STAR in the `STAR_ALIGN` module are a combination of: + +* Mandatory arguments or those that need to be evaluated within the scope of the module, as supplied in the [`script`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/modules/nf-core/software/star/align/main.nf#L49-L55) section of the module file. + +* An [`options.args`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/modules/nf-core/software/star/align/main.nf#L56) string of non-mandatory parameters that is set to be empty by default in the module but can be overwritten when including the module in the sub-workflow / workflow context via the `addParams` Nextflow option. + +The nf-core/rnaseq pipeline has a sub-workflow (see [terminology](https://github.com/nf-core/modules#terminology)) specifically to align reads with STAR and to sort, index and generate some basic stats on the resulting BAM files using SAMtools. At the top of this file we import the `STAR_ALIGN` module via the Nextflow [`include`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/subworkflows/nf-core/align_star.nf#L10) keyword and by default the options passed to the module via the `addParams` option are set as an empty Groovy map [here](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/subworkflows/nf-core/align_star.nf#L5); this in turn means `options.args` will be set to empty by default in the module file too. This is an intentional design choice and allows us to implement well-written sub-workflows composed of a chain of tools that by default run with the bare minimum parameter set for any given tool in order to make it much easier to share across pipelines and to provide the flexibility for users and developers to customise any non-mandatory arguments. + +When including the sub-workflow above in the main pipeline workflow we use the same `include` statement, however, we now have the ability to overwrite options for each of the tools in the sub-workflow including the [`align_options`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/workflows/rnaseq.nf#L225) variable that will be used specifically to overwrite the optional arguments passed to the `STAR_ALIGN` module. In this case, the options to be provided to `STAR_ALIGN` have been assigned sensible defaults by the developer(s) in the pipeline's [`modules.config`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/modules.config#L70-L74) and can be accessed and customised in the [workflow context](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/workflows/rnaseq.nf#L201-L204) too before eventually passing them to the sub-workflow as a Groovy map called `star_align_options`. These options will then be propagated from `workflow -> sub-workflow -> module`. + +As mentioned at the beginning of this section it may also be necessary for users to overwrite the options passed to modules to be able to customise specific aspects of the way in which a particular tool is executed by the pipeline. Given that all of the default module options are stored in the pipeline's `modules.config` as a [`params` variable](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/modules.config#L24-L25) it is also possible to overwrite any of these options via a custom config file. + +Say for example we want to append an additional, non-mandatory parameter (i.e. `--outFilterMismatchNmax 16`) to the arguments passed to the `STAR_ALIGN` module. Firstly, we need to copy across the default `args` specified in the [`modules.config`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/modules.config#L71) and create a custom config file that is a composite of the default `args` as well as the additional options you would like to provide. This is very important because Nextflow will overwrite the default value of `args` that you provide via the custom config. + +As you will see in the example below, we have: + +* appended `--outFilterMismatchNmax 16` to the default `args` used by the module. +* changed the default `publish_dir` value to where the files will eventually be published in the main results directory. +* appended `'bam':''` to the default value of `publish_files` so that the BAM files generated by the process will also be saved in the top-level results directory for the module. Note: `'out':'log'` means any file/directory ending in `out` will now be saved in a separate directory called `my_star_directory/log/`. + +```nextflow +params { + modules { + 'star_align' { + args = "--quantMode TranscriptomeSAM --twopassMode Basic --outSAMtype BAM Unsorted --readFilesCommand zcat --runRNGseed 0 --outFilterMultimapNmax 20 --alignSJDBoverhangMin 1 --outSAMattributes NH HI AS NM MD --quantTranscriptomeBan Singleend --outFilterMismatchNmax 16" + publish_dir = "my_star_directory" + publish_files = ['out':'log', 'tab':'log', 'bam':''] + } + } +} +``` + +### Updating containers + +The [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) implementation of this pipeline uses one container per process which makes it much easier to maintain and update software dependencies. If for some reason you need to use a different version of a particular tool with the pipeline then you just need to identify the `process` name and override the Nextflow `container` definition for that process using the `withName` declaration. For example, in the [nf-core/viralrecon](https://nf-co.re/viralrecon) pipeline a tool called [Pangolin](https://github.com/cov-lineages/pangolin) has been used during the COVID-19 pandemic to assign lineages to SARS-CoV-2 genome sequenced samples. Given that the lineage assignments change quite frequently it doesn't make sense to re-release the nf-core/viralrecon everytime a new version of Pangolin has been released. However, you can override the default container used by the pipeline by creating a custom config file and passing it as a command-line argument via `-c custom.config`. + +1. Check the default version used by the pipeline in the module file for [Pangolin](https://github.com/nf-core/viralrecon/blob/a85d5969f9025409e3618d6c280ef15ce417df65/modules/nf-core/software/pangolin/main.nf#L14-L19) +2. Find the latest version of the Biocontainer available on [Quay.io](https://quay.io/repository/biocontainers/pangolin?tag=latest&tab=tags) +3. Create the custom config accordingly: + + * For Docker: + + ```nextflow + process { + withName: PANGOLIN { + container = 'quay.io/biocontainers/pangolin:3.0.5--pyhdfd78af_0' + } + } + ``` + + * For Singularity: + + ```nextflow + process { + withName: PANGOLIN { + container = 'https://depot.galaxyproject.org/singularity/pangolin:3.0.5--pyhdfd78af_0' + } + } + ``` + + * For Conda: + + ```nextflow + process { + withName: PANGOLIN { + conda = 'bioconda::pangolin=3.0.5' + } + } + ``` + +> **NB:** If you wish to periodically update individual tool-specific results (e.g. Pangolin) generated by the pipeline then you must ensure to keep the `work/` directory otherwise the `-resume` ability of the pipeline will be compromised and it will restart from scratch. + +### nf-core/configs -See the main [Nextflow documentation](https://www.nextflow.io/docs/latest/config.html) for more information. +In most cases, you will only need to create a custom config as a one-off but if you and others within your organisation are likely to be running nf-core pipelines regularly and need to use the same settings regularly it may be a good idea to request that your custom config file is uploaded to the `nf-core/configs` git repository. Before you do this please can you test that the config file works with your pipeline of choice using the `-c` parameter. You can then create a pull request to the `nf-core/configs` repository with the addition of your config file, associated documentation file (see examples in [`nf-core/configs/docs`](https://github.com/nf-core/configs/tree/master/docs)), and amending [`nfcore_custom.config`](https://github.com/nf-core/configs/blob/master/nfcore_custom.config) to include your custom profile. -If you are likely to be running `nf-core` pipelines regularly it may be a good idea to request that your custom config file is uploaded to the `nf-core/configs` git repository. Before you do this please can you test that the config file works with your pipeline of choice using the `-c` parameter (see definition above). You can then create a pull request to the `nf-core/configs` repository with the addition of your config file, associated documentation file (see examples in [`nf-core/configs/docs`](https://github.com/nf-core/configs/tree/master/docs)), and amending [`nfcore_custom.config`](https://github.com/nf-core/configs/blob/master/nfcore_custom.config) to include your custom profile. +See the main [Nextflow documentation](https://www.nextflow.io/docs/latest/config.html) for more information about creating your own configuration files. If you have any questions or issues please send us a message on [Slack](https://nf-co.re/join/slack) on the [`#configs` channel](https://nfcore.slack.com/channels/configs). -### Running in the background +## Running in the background Nextflow handles job submissions and supervises the running jobs. The Nextflow process must run until the pipeline is finished. @@ -126,11 +274,11 @@ The Nextflow `-bg` flag launches Nextflow in the background, detached from your Alternatively, you can use `screen` / `tmux` or similar tool to create a detached session which you can log back into at a later time. Some HPC setups also allow you to run nextflow within a cluster job submitted your job scheduler (from where it submits more jobs). -#### Nextflow memory requirements +## Nextflow memory requirements In some cases, the Nextflow Java virtual machines can start to request a large amount of memory. We recommend adding the following line to your environment to limit this (typically in `~/.bashrc` or `~./bash_profile`): -```bash +```console NXF_OPTS='-Xms1g -Xmx4g' ``` diff --git a/environment.yml b/environment.yml deleted file mode 100644 index 88677053e..000000000 --- a/environment.yml +++ /dev/null @@ -1,15 +0,0 @@ -# You can use this file to create a conda environment for this pipeline: -# conda env create -f environment.yml -name: nf-core-chipseq-1.3.0dev -channels: - - conda-forge - - bioconda - - defaults -dependencies: - - conda-forge::python=3.7.3 - - conda-forge::markdown=3.1.1 - - conda-forge::pymdown-extensions=6.0 - - conda-forge::pygments=2.5.2 - # TODO nf-core: Add required software dependencies here - - bioconda::fastqc=0.11.8 - - bioconda::multiqc=1.7 diff --git a/lib/Headers.groovy b/lib/Headers.groovy deleted file mode 100644 index 15d1d3880..000000000 --- a/lib/Headers.groovy +++ /dev/null @@ -1,43 +0,0 @@ -/* - * This file holds several functions used to render the nf-core ANSI header. - */ - -class Headers { - - private static Map log_colours(Boolean monochrome_logs) { - Map colorcodes = [:] - colorcodes['reset'] = monochrome_logs ? '' : "\033[0m" - colorcodes['dim'] = monochrome_logs ? '' : "\033[2m" - colorcodes['black'] = monochrome_logs ? '' : "\033[0;30m" - colorcodes['green'] = monochrome_logs ? '' : "\033[0;32m" - colorcodes['yellow'] = monochrome_logs ? '' : "\033[0;33m" - colorcodes['yellow_bold'] = monochrome_logs ? '' : "\033[1;93m" - colorcodes['blue'] = monochrome_logs ? '' : "\033[0;34m" - colorcodes['purple'] = monochrome_logs ? '' : "\033[0;35m" - colorcodes['cyan'] = monochrome_logs ? '' : "\033[0;36m" - colorcodes['white'] = monochrome_logs ? '' : "\033[0;37m" - colorcodes['red'] = monochrome_logs ? '' : "\033[1;91m" - return colorcodes - } - - static String dashed_line(monochrome_logs) { - Map colors = log_colours(monochrome_logs) - return "-${colors.dim}----------------------------------------------------${colors.reset}-" - } - - static String nf_core(workflow, monochrome_logs) { - Map colors = log_colours(monochrome_logs) - String.format( - """\n - ${dashed_line(monochrome_logs)} - ${colors.green},--.${colors.black}/${colors.green},-.${colors.reset} - ${colors.blue} ___ __ __ __ ___ ${colors.green}/,-._.--~\'${colors.reset} - ${colors.blue} |\\ | |__ __ / ` / \\ |__) |__ ${colors.yellow}} {${colors.reset} - ${colors.blue} | \\| | \\__, \\__/ | \\ |___ ${colors.green}\\`-._,-`-,${colors.reset} - ${colors.green}`._,._,\'${colors.reset} - ${colors.purple} ${workflow.manifest.name} v${workflow.manifest.version}${colors.reset} - ${dashed_line(monochrome_logs)} - """.stripIndent() - ) - } -} diff --git a/lib/NfcoreSchema.groovy b/lib/NfcoreSchema.groovy old mode 100644 new mode 100755 index 52ee73043..8d6920dd6 --- a/lib/NfcoreSchema.groovy +++ b/lib/NfcoreSchema.groovy @@ -1,6 +1,6 @@ -/* - * This file holds several functions used to perform JSON parameter validation, help and summary rendering for the nf-core pipeline template. - */ +// +// This file holds several functions used to perform JSON parameter validation, help and summary rendering for the nf-core pipeline template. +// import org.everit.json.schema.Schema import org.everit.json.schema.loader.SchemaLoader @@ -13,16 +13,23 @@ import groovy.json.JsonBuilder class NfcoreSchema { - /* - * Function to loop over all parameters defined in schema and check - * whether the given paremeters adhere to the specificiations - */ + // + // Resolve Schema path relative to main workflow directory + // + public static String getSchemaPath(workflow, schema_filename='nextflow_schema.json') { + return "${workflow.projectDir}/${schema_filename}" + } + + // + // Function to loop over all parameters defined in schema and check + // whether the given parameters adhere to the specifications + // /* groovylint-disable-next-line UnusedPrivateMethodParameter */ - private static void validateParameters(params, jsonSchema, log) { + public static void validateParameters(workflow, params, log, schema_filename='nextflow_schema.json') { def has_error = false //=====================================================================// // Check for nextflow core params and unexpected params - def json = new File(jsonSchema).text + def json = new File(getSchemaPath(workflow, schema_filename=schema_filename)).text def Map schemaParams = (Map) new JsonSlurper().parseText(json).get('definitions') def nf_params = [ // Options for base `nextflow` command @@ -114,7 +121,8 @@ class NfcoreSchema { def params_ignore = params.schema_ignore_params.split(',') + 'schema_ignore_params' def expectedParamsLowerCase = expectedParams.collect{ it.replace("-", "").toLowerCase() } def specifiedParamLowerCase = specifiedParam.replace("-", "").toLowerCase() - if (!expectedParams.contains(specifiedParam) && !params_ignore.contains(specifiedParam) && !expectedParamsLowerCase.contains(specifiedParamLowerCase)) { + def isCamelCaseBug = (specifiedParam.contains("-") && !expectedParams.contains(specifiedParam) && expectedParamsLowerCase.contains(specifiedParamLowerCase)) + if (!expectedParams.contains(specifiedParam) && !params_ignore.contains(specifiedParam) && !isCamelCaseBug) { // Temporarily remove camelCase/camel-case params #1035 def unexpectedParamsLowerCase = unexpectedParams.collect{ it.replace("-", "").toLowerCase()} if (!unexpectedParamsLowerCase.contains(specifiedParamLowerCase)){ @@ -125,36 +133,36 @@ class NfcoreSchema { //=====================================================================// // Validate parameters against the schema - InputStream inputStream = new File(jsonSchema).newInputStream() - JSONObject rawSchema = new JSONObject(new JSONTokener(inputStream)) + InputStream input_stream = new File(getSchemaPath(workflow, schema_filename=schema_filename)).newInputStream() + JSONObject raw_schema = new JSONObject(new JSONTokener(input_stream)) // Remove anything that's in params.schema_ignore_params - rawSchema = removeIgnoredParams(rawSchema, params) + raw_schema = removeIgnoredParams(raw_schema, params) - Schema schema = SchemaLoader.load(rawSchema) + Schema schema = SchemaLoader.load(raw_schema) // Clean the parameters def cleanedParams = cleanParameters(params) // Convert to JSONObject def jsonParams = new JsonBuilder(cleanedParams) - JSONObject paramsJSON = new JSONObject(jsonParams.toString()) + JSONObject params_json = new JSONObject(jsonParams.toString()) // Validate try { - schema.validate(paramsJSON) + schema.validate(params_json) } catch (ValidationException e) { println '' log.error 'ERROR: Validation of pipeline parameters failed!' JSONObject exceptionJSON = e.toJSON() - printExceptions(exceptionJSON, paramsJSON, log) + printExceptions(exceptionJSON, params_json, log) println '' has_error = true } // Check for unexpected parameters if (unexpectedParams.size() > 0) { - Map colors = log_colours(params.monochrome_logs) + Map colors = NfcoreTemplate.logColours(params.monochrome_logs) println '' def warn_msg = 'Found unexpected parameters:' for (unexpectedParam in unexpectedParams) { @@ -170,266 +178,17 @@ class NfcoreSchema { } } - // Loop over nested exceptions and print the causingException - private static void printExceptions(exJSON, paramsJSON, log) { - def causingExceptions = exJSON['causingExceptions'] - if (causingExceptions.length() == 0) { - def m = exJSON['message'] =~ /required key \[([^\]]+)\] not found/ - // Missing required param - if (m.matches()) { - log.error "* Missing required parameter: --${m[0][1]}" - } - // Other base-level error - else if (exJSON['pointerToViolation'] == '#') { - log.error "* ${exJSON['message']}" - } - // Error with specific param - else { - def param = exJSON['pointerToViolation'] - ~/^#\// - def param_val = paramsJSON[param].toString() - log.error "* --${param}: ${exJSON['message']} (${param_val})" - } - } - for (ex in causingExceptions) { - printExceptions(ex, paramsJSON, log) - } - } - - // Remove an element from a JSONArray - private static JSONArray removeElement(jsonArray, element){ - def list = [] - int len = jsonArray.length() - for (int i=0;i - if(rawSchema.keySet().contains('definitions')){ - rawSchema.definitions.each { definition -> - for (key in definition.keySet()){ - if (definition[key].get("properties").keySet().contains(ignore_param)){ - // Remove the param to ignore - definition[key].get("properties").remove(ignore_param) - // If the param was required, change this - if (definition[key].has("required")) { - def cleaned_required = removeElement(definition[key].required, ignore_param) - definition[key].put("required", cleaned_required) - } - } - } - } - } - if(rawSchema.keySet().contains('properties') && rawSchema.get('properties').keySet().contains(ignore_param)) { - rawSchema.get("properties").remove(ignore_param) - } - if(rawSchema.keySet().contains('required') && rawSchema.required.contains(ignore_param)) { - def cleaned_required = removeElement(rawSchema.required, ignore_param) - rawSchema.put("required", cleaned_required) - } - } - return rawSchema - } - - private static Map cleanParameters(params) { - def new_params = params.getClass().newInstance(params) - for (p in params) { - // remove anything evaluating to false - if (!p['value']) { - new_params.remove(p.key) - } - // Cast MemoryUnit to String - if (p['value'].getClass() == nextflow.util.MemoryUnit) { - new_params.replace(p.key, p['value'].toString()) - } - // Cast Duration to String - if (p['value'].getClass() == nextflow.util.Duration) { - new_params.replace(p.key, p['value'].toString().replaceFirst(/d(?!\S)/, "day")) - } - // Cast LinkedHashMap to String - if (p['value'].getClass() == LinkedHashMap) { - new_params.replace(p.key, p['value'].toString()) - } - } - return new_params - } - - /* - * This method tries to read a JSON params file - */ - private static LinkedHashMap params_load(String json_schema) { - def params_map = new LinkedHashMap() - try { - params_map = params_read(json_schema) - } catch (Exception e) { - println "Could not read parameters settings from JSON. $e" - params_map = new LinkedHashMap() - } - return params_map - } - - private static Map log_colours(Boolean monochrome_logs) { - Map colorcodes = [:] - - // Reset / Meta - colorcodes['reset'] = monochrome_logs ? '' : "\033[0m" - colorcodes['bold'] = monochrome_logs ? '' : "\033[1m" - colorcodes['dim'] = monochrome_logs ? '' : "\033[2m" - colorcodes['underlined'] = monochrome_logs ? '' : "\033[4m" - colorcodes['blink'] = monochrome_logs ? '' : "\033[5m" - colorcodes['reverse'] = monochrome_logs ? '' : "\033[7m" - colorcodes['hidden'] = monochrome_logs ? '' : "\033[8m" - - // Regular Colors - colorcodes['black'] = monochrome_logs ? '' : "\033[0;30m" - colorcodes['red'] = monochrome_logs ? '' : "\033[0;31m" - colorcodes['green'] = monochrome_logs ? '' : "\033[0;32m" - colorcodes['yellow'] = monochrome_logs ? '' : "\033[0;33m" - colorcodes['blue'] = monochrome_logs ? '' : "\033[0;34m" - colorcodes['purple'] = monochrome_logs ? '' : "\033[0;35m" - colorcodes['cyan'] = monochrome_logs ? '' : "\033[0;36m" - colorcodes['white'] = monochrome_logs ? '' : "\033[0;37m" - - // Bold - colorcodes['bblack'] = monochrome_logs ? '' : "\033[1;30m" - colorcodes['bred'] = monochrome_logs ? '' : "\033[1;31m" - colorcodes['bgreen'] = monochrome_logs ? '' : "\033[1;32m" - colorcodes['byellow'] = monochrome_logs ? '' : "\033[1;33m" - colorcodes['bblue'] = monochrome_logs ? '' : "\033[1;34m" - colorcodes['bpurple'] = monochrome_logs ? '' : "\033[1;35m" - colorcodes['bcyan'] = monochrome_logs ? '' : "\033[1;36m" - colorcodes['bwhite'] = monochrome_logs ? '' : "\033[1;37m" - - // Underline - colorcodes['ublack'] = monochrome_logs ? '' : "\033[4;30m" - colorcodes['ured'] = monochrome_logs ? '' : "\033[4;31m" - colorcodes['ugreen'] = monochrome_logs ? '' : "\033[4;32m" - colorcodes['uyellow'] = monochrome_logs ? '' : "\033[4;33m" - colorcodes['ublue'] = monochrome_logs ? '' : "\033[4;34m" - colorcodes['upurple'] = monochrome_logs ? '' : "\033[4;35m" - colorcodes['ucyan'] = monochrome_logs ? '' : "\033[4;36m" - colorcodes['uwhite'] = monochrome_logs ? '' : "\033[4;37m" - - // High Intensity - colorcodes['iblack'] = monochrome_logs ? '' : "\033[0;90m" - colorcodes['ired'] = monochrome_logs ? '' : "\033[0;91m" - colorcodes['igreen'] = monochrome_logs ? '' : "\033[0;92m" - colorcodes['iyellow'] = monochrome_logs ? '' : "\033[0;93m" - colorcodes['iblue'] = monochrome_logs ? '' : "\033[0;94m" - colorcodes['ipurple'] = monochrome_logs ? '' : "\033[0;95m" - colorcodes['icyan'] = monochrome_logs ? '' : "\033[0;96m" - colorcodes['iwhite'] = monochrome_logs ? '' : "\033[0;97m" - - // Bold High Intensity - colorcodes['biblack'] = monochrome_logs ? '' : "\033[1;90m" - colorcodes['bired'] = monochrome_logs ? '' : "\033[1;91m" - colorcodes['bigreen'] = monochrome_logs ? '' : "\033[1;92m" - colorcodes['biyellow'] = monochrome_logs ? '' : "\033[1;93m" - colorcodes['biblue'] = monochrome_logs ? '' : "\033[1;94m" - colorcodes['bipurple'] = monochrome_logs ? '' : "\033[1;95m" - colorcodes['bicyan'] = monochrome_logs ? '' : "\033[1;96m" - colorcodes['biwhite'] = monochrome_logs ? '' : "\033[1;97m" - - return colorcodes - } - - static String dashed_line(monochrome_logs) { - Map colors = log_colours(monochrome_logs) - return "-${colors.dim}----------------------------------------------------${colors.reset}-" - } - - /* - Method to actually read in JSON file using Groovy. - Group (as Key), values are all parameters - - Parameter1 as Key, Description as Value - - Parameter2 as Key, Description as Value - .... - Group - - - */ - private static LinkedHashMap params_read(String json_schema) throws Exception { - def json = new File(json_schema).text - def Map schema_definitions = (Map) new JsonSlurper().parseText(json).get('definitions') - def Map schema_properties = (Map) new JsonSlurper().parseText(json).get('properties') - /* Tree looks like this in nf-core schema - * definitions <- this is what the first get('definitions') gets us - group 1 - title - description - properties - parameter 1 - type - description - parameter 2 - type - description - group 2 - title - description - properties - parameter 1 - type - description - * properties <- parameters can also be ungrouped, outside of definitions - parameter 1 - type - description - */ - - // Grouped params - def params_map = new LinkedHashMap() - schema_definitions.each { key, val -> - def Map group = schema_definitions."$key".properties // Gets the property object of the group - def title = schema_definitions."$key".title - def sub_params = new LinkedHashMap() - group.each { innerkey, value -> - sub_params.put(innerkey, value) - } - params_map.put(title, sub_params) - } - - // Ungrouped params - def ungrouped_params = new LinkedHashMap() - schema_properties.each { innerkey, value -> - ungrouped_params.put(innerkey, value) - } - params_map.put("Other parameters", ungrouped_params) - - return params_map - } - - /* - * Get maximum number of characters across all parameter names - */ - private static Integer params_max_chars(params_map) { - Integer max_chars = 0 - for (group in params_map.keySet()) { - def group_params = params_map.get(group) // This gets the parameters of that particular group - for (param in group_params.keySet()) { - if (param.size() > max_chars) { - max_chars = param.size() - } - } - } - return max_chars - } - - /* - * Beautify parameters for --help - */ - private static String params_help(workflow, params, json_schema, command) { - Map colors = log_colours(params.monochrome_logs) + // + // Beautify parameters for --help + // + public static String paramsHelp(workflow, params, command, schema_filename='nextflow_schema.json') { + Map colors = NfcoreTemplate.logColours(params.monochrome_logs) Integer num_hidden = 0 String output = '' output += 'Typical pipeline command:\n\n' output += " ${colors.cyan}${command}${colors.reset}\n\n" - Map params_map = params_load(json_schema) - Integer max_chars = params_max_chars(params_map) + 1 + Map params_map = paramsLoad(getSchemaPath(workflow, schema_filename=schema_filename)) + Integer max_chars = paramsMaxChars(params_map) + 1 Integer desc_indent = max_chars + 14 Integer dec_linewidth = 160 - desc_indent for (group in params_map.keySet()) { @@ -469,18 +228,17 @@ class NfcoreSchema { output += group_output } } - output += dashed_line(params.monochrome_logs) if (num_hidden > 0){ - output += colors.dim + "\n Hiding $num_hidden params, use --show_hidden_params to show.\n" + colors.reset - output += dashed_line(params.monochrome_logs) + output += colors.dim + "!! Hiding $num_hidden params, use --show_hidden_params to show them !!\n" + colors.reset } + output += NfcoreTemplate.dashedLine(params.monochrome_logs) return output } - /* - * Groovy Map summarising parameters/workflow options used by the pipeline - */ - private static LinkedHashMap params_summary_map(workflow, params, json_schema) { + // + // Groovy Map summarising parameters/workflow options used by the pipeline + // + public static LinkedHashMap paramsSummaryMap(workflow, params, schema_filename='nextflow_schema.json') { // Get a selection of core Nextflow workflow options def Map workflow_summary = [:] if (workflow.revision) { @@ -503,7 +261,7 @@ class NfcoreSchema { // Get pipeline parameters defined in JSON Schema def Map params_summary = [:] def blacklist = ['hostnames'] - def params_map = params_load(json_schema) + def params_map = paramsLoad(getSchemaPath(workflow, schema_filename=schema_filename)) for (group in params_map.keySet()) { def sub_params = new LinkedHashMap() def group_params = params_map.get(group) // This gets the parameters of that particular group @@ -546,14 +304,14 @@ class NfcoreSchema { return [ 'Core Nextflow options' : workflow_summary ] << params_summary } - /* - * Beautify parameters for summary and return as string - */ - private static String params_summary_log(workflow, params, json_schema) { - Map colors = log_colours(params.monochrome_logs) + // + // Beautify parameters for summary and return as string + // + public static String paramsSummaryLog(workflow, params) { + Map colors = NfcoreTemplate.logColours(params.monochrome_logs) String output = '' - def params_map = params_summary_map(workflow, params, json_schema) - def max_chars = params_max_chars(params_map) + def params_map = paramsSummaryMap(workflow, params) + def max_chars = paramsMaxChars(params_map) for (group in params_map.keySet()) { def group_params = params_map.get(group) // This gets the parameters of that particular group if (group_params) { @@ -564,10 +322,196 @@ class NfcoreSchema { output += '\n' } } - output += dashed_line(params.monochrome_logs) - output += colors.dim + "\n Only displaying parameters that differ from defaults.\n" + colors.reset - output += dashed_line(params.monochrome_logs) + output += "!! Only displaying parameters that differ from the pipeline defaults !!\n" + output += NfcoreTemplate.dashedLine(params.monochrome_logs) return output } + // + // Loop over nested exceptions and print the causingException + // + private static void printExceptions(ex_json, params_json, log) { + def causingExceptions = ex_json['causingExceptions'] + if (causingExceptions.length() == 0) { + def m = ex_json['message'] =~ /required key \[([^\]]+)\] not found/ + // Missing required param + if (m.matches()) { + log.error "* Missing required parameter: --${m[0][1]}" + } + // Other base-level error + else if (ex_json['pointerToViolation'] == '#') { + log.error "* ${ex_json['message']}" + } + // Error with specific param + else { + def param = ex_json['pointerToViolation'] - ~/^#\// + def param_val = params_json[param].toString() + log.error "* --${param}: ${ex_json['message']} (${param_val})" + } + } + for (ex in causingExceptions) { + printExceptions(ex, params_json, log) + } + } + + // + // Remove an element from a JSONArray + // + private static JSONArray removeElement(json_array, element) { + def list = [] + int len = json_array.length() + for (int i=0;i + if(raw_schema.keySet().contains('definitions')){ + raw_schema.definitions.each { definition -> + for (key in definition.keySet()){ + if (definition[key].get("properties").keySet().contains(ignore_param)){ + // Remove the param to ignore + definition[key].get("properties").remove(ignore_param) + // If the param was required, change this + if (definition[key].has("required")) { + def cleaned_required = removeElement(definition[key].required, ignore_param) + definition[key].put("required", cleaned_required) + } + } + } + } + } + if(raw_schema.keySet().contains('properties') && raw_schema.get('properties').keySet().contains(ignore_param)) { + raw_schema.get("properties").remove(ignore_param) + } + if(raw_schema.keySet().contains('required') && raw_schema.required.contains(ignore_param)) { + def cleaned_required = removeElement(raw_schema.required, ignore_param) + raw_schema.put("required", cleaned_required) + } + } + return raw_schema + } + + // + // Clean and check parameters relative to Nextflow native classes + // + private static Map cleanParameters(params) { + def new_params = params.getClass().newInstance(params) + for (p in params) { + // remove anything evaluating to false + if (!p['value']) { + new_params.remove(p.key) + } + // Cast MemoryUnit to String + if (p['value'].getClass() == nextflow.util.MemoryUnit) { + new_params.replace(p.key, p['value'].toString()) + } + // Cast Duration to String + if (p['value'].getClass() == nextflow.util.Duration) { + new_params.replace(p.key, p['value'].toString().replaceFirst(/d(?!\S)/, "day")) + } + // Cast LinkedHashMap to String + if (p['value'].getClass() == LinkedHashMap) { + new_params.replace(p.key, p['value'].toString()) + } + } + return new_params + } + + // + // This function tries to read a JSON params file + // + private static LinkedHashMap paramsLoad(String json_schema) { + def params_map = new LinkedHashMap() + try { + params_map = paramsRead(json_schema) + } catch (Exception e) { + println "Could not read parameters settings from JSON. $e" + params_map = new LinkedHashMap() + } + return params_map + } + + // + // Method to actually read in JSON file using Groovy. + // Group (as Key), values are all parameters + // - Parameter1 as Key, Description as Value + // - Parameter2 as Key, Description as Value + // .... + // Group + // - + private static LinkedHashMap paramsRead(String json_schema) throws Exception { + def json = new File(json_schema).text + def Map schema_definitions = (Map) new JsonSlurper().parseText(json).get('definitions') + def Map schema_properties = (Map) new JsonSlurper().parseText(json).get('properties') + /* Tree looks like this in nf-core schema + * definitions <- this is what the first get('definitions') gets us + group 1 + title + description + properties + parameter 1 + type + description + parameter 2 + type + description + group 2 + title + description + properties + parameter 1 + type + description + * properties <- parameters can also be ungrouped, outside of definitions + parameter 1 + type + description + */ + + // Grouped params + def params_map = new LinkedHashMap() + schema_definitions.each { key, val -> + def Map group = schema_definitions."$key".properties // Gets the property object of the group + def title = schema_definitions."$key".title + def sub_params = new LinkedHashMap() + group.each { innerkey, value -> + sub_params.put(innerkey, value) + } + params_map.put(title, sub_params) + } + + // Ungrouped params + def ungrouped_params = new LinkedHashMap() + schema_properties.each { innerkey, value -> + ungrouped_params.put(innerkey, value) + } + params_map.put("Other parameters", ungrouped_params) + + return params_map + } + + // + // Get maximum number of characters across all parameter names + // + private static Integer paramsMaxChars(params_map) { + Integer max_chars = 0 + for (group in params_map.keySet()) { + def group_params = params_map.get(group) // This gets the parameters of that particular group + for (param in group_params.keySet()) { + if (param.size() > max_chars) { + max_chars = param.size() + } + } + } + return max_chars + } } diff --git a/lib/NfcoreTemplate.groovy b/lib/NfcoreTemplate.groovy new file mode 100755 index 000000000..b6e689ec8 --- /dev/null +++ b/lib/NfcoreTemplate.groovy @@ -0,0 +1,266 @@ +// +// This file holds several functions used within the nf-core pipeline template. +// + +import org.yaml.snakeyaml.Yaml + +class NfcoreTemplate { + + // + // Check AWS Batch related parameters have been specified correctly + // + public static void awsBatch(workflow, params) { + if (workflow.profile.contains('awsbatch')) { + // Check params.awsqueue and params.awsregion have been set if running on AWSBatch + assert (params.awsqueue && params.awsregion) : "Specify correct --awsqueue and --awsregion parameters on AWSBatch!" + // Check outdir paths to be S3 buckets if running on AWSBatch + assert params.outdir.startsWith('s3:') : "Outdir not on S3 - specify S3 Bucket to run on AWSBatch!" + } + } + + // + // Check params.hostnames + // + public static void hostName(workflow, params, log) { + Map colors = logColours(params.monochrome_logs) + if (params.hostnames) { + def hostname = "hostname".execute().text.trim() + params.hostnames.each { prof, hnames -> + hnames.each { hname -> + if (hostname.contains(hname) && !workflow.profile.contains(prof)) { + log.info "=${colors.yellow}====================================================${colors.reset}=\n" + + "${colors.yellow}WARN: You are running with `-profile $workflow.profile`\n" + + " but your machine hostname is ${colors.white}'$hostname'${colors.reset}.\n" + + " ${colors.yellow_bold}Please use `-profile $prof${colors.reset}`\n" + + "=${colors.yellow}====================================================${colors.reset}=" + } + } + } + } + } + + // + // Construct and send completion email + // + public static void email(workflow, params, summary_params, projectDir, log, multiqc_report=[]) { + + // Set up the e-mail variables + def subject = "[$workflow.manifest.name] Successful: $workflow.runName" + if (!workflow.success) { + subject = "[$workflow.manifest.name] FAILED: $workflow.runName" + } + + def summary = [:] + for (group in summary_params.keySet()) { + summary << summary_params[group] + } + + def misc_fields = [:] + misc_fields['Date Started'] = workflow.start + misc_fields['Date Completed'] = workflow.complete + misc_fields['Pipeline script file path'] = workflow.scriptFile + misc_fields['Pipeline script hash ID'] = workflow.scriptId + if (workflow.repository) misc_fields['Pipeline repository Git URL'] = workflow.repository + if (workflow.commitId) misc_fields['Pipeline repository Git Commit'] = workflow.commitId + if (workflow.revision) misc_fields['Pipeline Git branch/tag'] = workflow.revision + misc_fields['Nextflow Version'] = workflow.nextflow.version + misc_fields['Nextflow Build'] = workflow.nextflow.build + misc_fields['Nextflow Compile Timestamp'] = workflow.nextflow.timestamp + + def email_fields = [:] + email_fields['version'] = workflow.manifest.version + email_fields['runName'] = workflow.runName + email_fields['success'] = workflow.success + email_fields['dateComplete'] = workflow.complete + email_fields['duration'] = workflow.duration + email_fields['exitStatus'] = workflow.exitStatus + email_fields['errorMessage'] = (workflow.errorMessage ?: 'None') + email_fields['errorReport'] = (workflow.errorReport ?: 'None') + email_fields['commandLine'] = workflow.commandLine + email_fields['projectDir'] = workflow.projectDir + email_fields['summary'] = summary << misc_fields + + // On success try attach the multiqc report + def mqc_report = null + try { + if (workflow.success) { + mqc_report = multiqc_report.getVal() + if (mqc_report.getClass() == ArrayList && mqc_report.size() >= 1) { + if (mqc_report.size() > 1) { + log.warn "[$workflow.manifest.name] Found multiple reports from process 'MULTIQC', will use only one" + } + mqc_report = mqc_report[0] + } + } + } catch (all) { + if (multiqc_report) { + log.warn "[$workflow.manifest.name] Could not attach MultiQC report to summary email" + } + } + + // Check if we are only sending emails on failure + def email_address = params.email + if (!params.email && params.email_on_fail && !workflow.success) { + email_address = params.email_on_fail + } + + // Render the TXT template + def engine = new groovy.text.GStringTemplateEngine() + def tf = new File("$projectDir/assets/email_template.txt") + def txt_template = engine.createTemplate(tf).make(email_fields) + def email_txt = txt_template.toString() + + // Render the HTML template + def hf = new File("$projectDir/assets/email_template.html") + def html_template = engine.createTemplate(hf).make(email_fields) + def email_html = html_template.toString() + + // Render the sendmail template + def max_multiqc_email_size = params.max_multiqc_email_size as nextflow.util.MemoryUnit + def smail_fields = [ email: email_address, subject: subject, email_txt: email_txt, email_html: email_html, projectDir: "$projectDir", mqcFile: mqc_report, mqcMaxSize: max_multiqc_email_size.toBytes() ] + def sf = new File("$projectDir/assets/sendmail_template.txt") + def sendmail_template = engine.createTemplate(sf).make(smail_fields) + def sendmail_html = sendmail_template.toString() + + // Send the HTML e-mail + Map colors = logColours(params.monochrome_logs) + if (email_address) { + try { + if (params.plaintext_email) { throw GroovyException('Send plaintext e-mail, not HTML') } + // Try to send HTML e-mail using sendmail + [ 'sendmail', '-t' ].execute() << sendmail_html + log.info "-${colors.purple}[$workflow.manifest.name]${colors.green} Sent summary e-mail to $email_address (sendmail)-" + } catch (all) { + // Catch failures and try with plaintext + def mail_cmd = [ 'mail', '-s', subject, '--content-type=text/html', email_address ] + if ( mqc_report.size() <= max_multiqc_email_size.toBytes() ) { + mail_cmd += [ '-A', mqc_report ] + } + mail_cmd.execute() << email_html + log.info "-${colors.purple}[$workflow.manifest.name]${colors.green} Sent summary e-mail to $email_address (mail)-" + } + } + + // Write summary e-mail HTML to a file + def output_d = new File("${params.outdir}/pipeline_info/") + if (!output_d.exists()) { + output_d.mkdirs() + } + def output_hf = new File(output_d, "pipeline_report.html") + output_hf.withWriter { w -> w << email_html } + def output_tf = new File(output_d, "pipeline_report.txt") + output_tf.withWriter { w -> w << email_txt } + } + + // + // Print pipeline summary on completion + // + public static void summary(workflow, params, log) { + Map colors = logColours(params.monochrome_logs) + if (workflow.success) { + if (workflow.stats.ignoredCount == 0) { + log.info "-${colors.purple}[$workflow.manifest.name]${colors.green} Pipeline completed successfully${colors.reset}-" + } else { + log.info "-${colors.purple}[$workflow.manifest.name]${colors.red} Pipeline completed successfully, but with errored process(es) ${colors.reset}-" + } + } else { + hostName(workflow, params, log) + log.info "-${colors.purple}[$workflow.manifest.name]${colors.red} Pipeline completed with errors${colors.reset}-" + } + } + + // + // ANSII Colours used for terminal logging + // + public static Map logColours(Boolean monochrome_logs) { + Map colorcodes = [:] + + // Reset / Meta + colorcodes['reset'] = monochrome_logs ? '' : "\033[0m" + colorcodes['bold'] = monochrome_logs ? '' : "\033[1m" + colorcodes['dim'] = monochrome_logs ? '' : "\033[2m" + colorcodes['underlined'] = monochrome_logs ? '' : "\033[4m" + colorcodes['blink'] = monochrome_logs ? '' : "\033[5m" + colorcodes['reverse'] = monochrome_logs ? '' : "\033[7m" + colorcodes['hidden'] = monochrome_logs ? '' : "\033[8m" + + // Regular Colors + colorcodes['black'] = monochrome_logs ? '' : "\033[0;30m" + colorcodes['red'] = monochrome_logs ? '' : "\033[0;31m" + colorcodes['green'] = monochrome_logs ? '' : "\033[0;32m" + colorcodes['yellow'] = monochrome_logs ? '' : "\033[0;33m" + colorcodes['blue'] = monochrome_logs ? '' : "\033[0;34m" + colorcodes['purple'] = monochrome_logs ? '' : "\033[0;35m" + colorcodes['cyan'] = monochrome_logs ? '' : "\033[0;36m" + colorcodes['white'] = monochrome_logs ? '' : "\033[0;37m" + + // Bold + colorcodes['bblack'] = monochrome_logs ? '' : "\033[1;30m" + colorcodes['bred'] = monochrome_logs ? '' : "\033[1;31m" + colorcodes['bgreen'] = monochrome_logs ? '' : "\033[1;32m" + colorcodes['byellow'] = monochrome_logs ? '' : "\033[1;33m" + colorcodes['bblue'] = monochrome_logs ? '' : "\033[1;34m" + colorcodes['bpurple'] = monochrome_logs ? '' : "\033[1;35m" + colorcodes['bcyan'] = monochrome_logs ? '' : "\033[1;36m" + colorcodes['bwhite'] = monochrome_logs ? '' : "\033[1;37m" + + // Underline + colorcodes['ublack'] = monochrome_logs ? '' : "\033[4;30m" + colorcodes['ured'] = monochrome_logs ? '' : "\033[4;31m" + colorcodes['ugreen'] = monochrome_logs ? '' : "\033[4;32m" + colorcodes['uyellow'] = monochrome_logs ? '' : "\033[4;33m" + colorcodes['ublue'] = monochrome_logs ? '' : "\033[4;34m" + colorcodes['upurple'] = monochrome_logs ? '' : "\033[4;35m" + colorcodes['ucyan'] = monochrome_logs ? '' : "\033[4;36m" + colorcodes['uwhite'] = monochrome_logs ? '' : "\033[4;37m" + + // High Intensity + colorcodes['iblack'] = monochrome_logs ? '' : "\033[0;90m" + colorcodes['ired'] = monochrome_logs ? '' : "\033[0;91m" + colorcodes['igreen'] = monochrome_logs ? '' : "\033[0;92m" + colorcodes['iyellow'] = monochrome_logs ? '' : "\033[0;93m" + colorcodes['iblue'] = monochrome_logs ? '' : "\033[0;94m" + colorcodes['ipurple'] = monochrome_logs ? '' : "\033[0;95m" + colorcodes['icyan'] = monochrome_logs ? '' : "\033[0;96m" + colorcodes['iwhite'] = monochrome_logs ? '' : "\033[0;97m" + + // Bold High Intensity + colorcodes['biblack'] = monochrome_logs ? '' : "\033[1;90m" + colorcodes['bired'] = monochrome_logs ? '' : "\033[1;91m" + colorcodes['bigreen'] = monochrome_logs ? '' : "\033[1;92m" + colorcodes['biyellow'] = monochrome_logs ? '' : "\033[1;93m" + colorcodes['biblue'] = monochrome_logs ? '' : "\033[1;94m" + colorcodes['bipurple'] = monochrome_logs ? '' : "\033[1;95m" + colorcodes['bicyan'] = monochrome_logs ? '' : "\033[1;96m" + colorcodes['biwhite'] = monochrome_logs ? '' : "\033[1;97m" + + return colorcodes + } + + // + // Does what is says on the tin + // + public static String dashedLine(monochrome_logs) { + Map colors = logColours(monochrome_logs) + return "-${colors.dim}----------------------------------------------------${colors.reset}-" + } + + // + // nf-core logo + // + public static String logo(workflow, monochrome_logs) { + Map colors = logColours(monochrome_logs) + String.format( + """\n + ${dashedLine(monochrome_logs)} + ${colors.green},--.${colors.black}/${colors.green},-.${colors.reset} + ${colors.blue} ___ __ __ __ ___ ${colors.green}/,-._.--~\'${colors.reset} + ${colors.blue} |\\ | |__ __ / ` / \\ |__) |__ ${colors.yellow}} {${colors.reset} + ${colors.blue} | \\| | \\__, \\__/ | \\ |___ ${colors.green}\\`-._,-`-,${colors.reset} + ${colors.green}`._,._,\'${colors.reset} + ${colors.purple} ${workflow.manifest.name} v${workflow.manifest.version}${colors.reset} + ${dashedLine(monochrome_logs)} + """.stripIndent() + ) + } +} diff --git a/lib/Utils.groovy b/lib/Utils.groovy new file mode 100755 index 000000000..18173e985 --- /dev/null +++ b/lib/Utils.groovy @@ -0,0 +1,47 @@ +// +// This file holds several Groovy functions that could be useful for any Nextflow pipeline +// + +import org.yaml.snakeyaml.Yaml + +class Utils { + + // + // When running with -profile conda, warn if channels have not been set-up appropriately + // + public static void checkCondaChannels(log) { + Yaml parser = new Yaml() + def channels = [] + try { + def config = parser.load("conda config --show channels".execute().text) + channels = config.channels + } catch(NullPointerException | IOException e) { + log.warn "Could not verify conda channel configuration." + return + } + + // Check that all channels are present + def required_channels = ['conda-forge', 'bioconda', 'defaults'] + def conda_check_failed = !required_channels.every { ch -> ch in channels } + + // Check that they are in the right order + conda_check_failed |= !(channels.indexOf('conda-forge') < channels.indexOf('bioconda')) + conda_check_failed |= !(channels.indexOf('bioconda') < channels.indexOf('defaults')) + + if (conda_check_failed) { + log.warn "=============================================================================\n" + + " There is a problem with your Conda configuration!\n\n" + + " You will need to set-up the conda-forge and bioconda channels correctly.\n" + + " Please refer to https://bioconda.github.io/user/install.html#set-up-channels\n" + + " NB: The order of the channels matters!\n" + + "===================================================================================" + } + } + + // + // Join module args with appropriate spacing + // + public static String joinModuleArgs(args_list) { + return ' ' + args_list.join(' ') + } +} diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy new file mode 100755 index 000000000..4ca6323ae --- /dev/null +++ b/lib/WorkflowChipseq.groovy @@ -0,0 +1,59 @@ +// +// This file holds several functions specific to the workflow/chipseq.nf in the nf-core/chipseq pipeline +// + +class WorkflowChipseq { + + // + // Check and validate parameters + // + public static void initialise(params, log) { + genomeExistsError(params, log) + + if (!params.fasta) { + log.error "Genome fasta file not specified with e.g. '--fasta genome.fa' or via a detectable config file." + System.exit(1) + } + } + + // + // Get workflow summary for MultiQC + // + public static String paramsSummaryMultiqc(workflow, summary) { + String summary_section = '' + for (group in summary.keySet()) { + def group_params = summary.get(group) // This gets the parameters of that particular group + if (group_params) { + summary_section += "

$group

\n" + summary_section += " \n" + } + } + + String yaml_file_text = "id: '${workflow.manifest.name.replace('/','-')}-summary'\n" + yaml_file_text += "description: ' - this information is collected when the pipeline is started.'\n" + yaml_file_text += "section_name: '${workflow.manifest.name} Workflow Summary'\n" + yaml_file_text += "section_href: 'https://github.com/${workflow.manifest.name}'\n" + yaml_file_text += "plot_type: 'html'\n" + yaml_file_text += "data: |\n" + yaml_file_text += "${summary_section}" + return yaml_file_text + } + + // + // Exit pipeline if incorrect --genome key provided + // + private static void genomeExistsError(params, log) { + if (params.genomes && params.genome && !params.genomes.containsKey(params.genome)) { + log.error "=============================================================================\n" + + " Genome '${params.genome}' not found in any config files provided to the pipeline.\n" + + " Currently, the available genome keys are:\n" + + " ${params.genomes.keySet().join(", ")}\n" + + "===================================================================================" + System.exit(1) + } + } +} diff --git a/lib/WorkflowMain.groovy b/lib/WorkflowMain.groovy new file mode 100755 index 000000000..bc960fcc8 --- /dev/null +++ b/lib/WorkflowMain.groovy @@ -0,0 +1,94 @@ +// +// This file holds several functions specific to the main.nf workflow in the nf-core/chipseq pipeline +// + +class WorkflowMain { + + // + // Citation string for pipeline + // + public static String citation(workflow) { + return "If you use ${workflow.manifest.name} for your analysis please cite:\n\n" + + // TODO nf-core: Add Zenodo DOI for pipeline after first release + //"* The pipeline\n" + + //" https://doi.org/10.5281/zenodo.XXXXXXX\n\n" + + "* The nf-core framework\n" + + " https://doi.org/10.1038/s41587-020-0439-x\n\n" + + "* Software dependencies\n" + + " https://github.com/${workflow.manifest.name}/blob/master/CITATIONS.md" + } + + // + // Print help to screen if required + // + public static String help(workflow, params, log) { + def command = "nextflow run ${workflow.manifest.name} --input samplesheet.csv --genome GRCh37 -profile docker" + def help_string = '' + help_string += NfcoreTemplate.logo(workflow, params.monochrome_logs) + help_string += NfcoreSchema.paramsHelp(workflow, params, command) + help_string += '\n' + citation(workflow) + '\n' + help_string += NfcoreTemplate.dashedLine(params.monochrome_logs) + return help_string + } + + // + // Print parameter summary log to screen + // + public static String paramsSummaryLog(workflow, params, log) { + def summary_log = '' + summary_log += NfcoreTemplate.logo(workflow, params.monochrome_logs) + summary_log += NfcoreSchema.paramsSummaryLog(workflow, params) + summary_log += '\n' + citation(workflow) + '\n' + summary_log += NfcoreTemplate.dashedLine(params.monochrome_logs) + return summary_log + } + + // + // Validate parameters and print summary to screen + // + public static void initialise(workflow, params, log) { + // Print help to screen if required + if (params.help) { + log.info help(workflow, params, log) + System.exit(0) + } + + // Validate workflow parameters via the JSON schema + if (params.validate_params) { + NfcoreSchema.validateParameters(workflow, params, log) + } + + // Print parameter summary log to screen + log.info paramsSummaryLog(workflow, params, log) + + // Check that conda channels are set-up correctly + if (params.enable_conda) { + Utils.checkCondaChannels(log) + } + + // Check AWS batch settings + NfcoreTemplate.awsBatch(workflow, params) + + // Check the hostnames against configured profiles + NfcoreTemplate.hostName(workflow, params, log) + + // Check input has been provided + if (!params.input) { + log.error "Please provide an input samplesheet to the pipeline e.g. '--input samplesheet.csv'" + System.exit(1) + } + } + + // + // Get attribute from genome config file e.g. fasta + // + public static String getGenomeAttribute(params, attribute) { + def val = '' + if (params.genomes && params.genome && params.genomes.containsKey(params.genome)) { + if (params.genomes[ params.genome ].containsKey(attribute)) { + val = params.genomes[ params.genome ][ attribute ] + } + } + return val + } +} diff --git a/main.nf b/main.nf index a7f4ec153..7a90164a5 100644 --- a/main.nf +++ b/main.nf @@ -1,390 +1,63 @@ #!/usr/bin/env nextflow /* ======================================================================================== - nf-core/chipseq + nf-core/chipseq ======================================================================================== - nf-core/chipseq Analysis Pipeline. - #### Homepage / Documentation - https://github.com/nf-core/chipseq + Github : https://github.com/nf-core/chipseq + Website: https://nf-co.re/chipseq + Slack : https://nfcore.slack.com/channels/chipseq ---------------------------------------------------------------------------------------- */ -log.info Headers.nf_core(workflow, params.monochrome_logs) - -//////////////////////////////////////////////////// -/* -- PRINT HELP -- */ -////////////////////////////////////////////////////+ -def json_schema = "$projectDir/nextflow_schema.json" -if (params.help) { - def command = "nextflow run nf-core/chipseq --input '*_R{1,2}.fastq.gz' -profile docker" - log.info NfcoreSchema.params_help(workflow, params, json_schema, command) - exit 0 -} - -//////////////////////////////////////////////////// -/* -- VALIDATE PARAMETERS -- */ -////////////////////////////////////////////////////+ -if (params.validate_params) { - NfcoreSchema.validateParameters(params, json_schema, log) -} - -//////////////////////////////////////////////////// -/* -- Collect configuration parameters -- */ -//////////////////////////////////////////////////// - -// Check if genome exists in the config file -if (params.genomes && params.genome && !params.genomes.containsKey(params.genome)) { - exit 1, "The provided genome '${params.genome}' is not available in the iGenomes file. Currently the available genomes are ${params.genomes.keySet().join(', ')}" -} - -// TODO nf-core: Add any reference files that are needed -// Configurable reference genomes -// -// NOTE - THIS IS NOT USED IN THIS PIPELINE, EXAMPLE ONLY -// If you want to use the channel below in a process, define the following: -// input: -// file fasta from ch_fasta -// -params.fasta = params.genome ? params.genomes[ params.genome ].fasta ?: false : false -if (params.fasta) { ch_fasta = file(params.fasta, checkIfExists: true) } - -// Check AWS batch settings -if (workflow.profile.contains('awsbatch')) { - // AWSBatch sanity checking - if (!params.awsqueue || !params.awsregion) exit 1, 'Specify correct --awsqueue and --awsregion parameters on AWSBatch!' - // Check outdir paths to be S3 buckets if running on AWSBatch - // related: https://github.com/nextflow-io/nextflow/issues/813 - if (!params.outdir.startsWith('s3:')) exit 1, 'Outdir not on S3 - specify S3 Bucket to run on AWSBatch!' - // Prevent trace files to be stored on S3 since S3 does not support rolling files. - if (params.tracedir.startsWith('s3:')) exit 1, 'Specify a local tracedir or run without trace! S3 cannot be used for tracefiles.' -} - -// Stage config files -ch_multiqc_config = file("$projectDir/assets/multiqc_config.yaml", checkIfExists: true) -ch_multiqc_custom_config = params.multiqc_config ? Channel.fromPath(params.multiqc_config, checkIfExists: true) : Channel.empty() -ch_output_docs = file("$projectDir/docs/output.md", checkIfExists: true) -ch_output_docs_images = file("$projectDir/docs/images/", checkIfExists: true) +nextflow.enable.dsl = 2 /* - * Create a channel for input read files - */ -if (params.input_paths) { - if (params.single_end) { - Channel - .from(params.input_paths) - .map { row -> [ row[0], [ file(row[1][0], checkIfExists: true) ] ] } - .ifEmpty { exit 1, 'params.input_paths was empty - no input files supplied' } - .into { ch_read_files_fastqc; ch_read_files_trimming } - } else { - Channel - .from(params.input_paths) - .map { row -> [ row[0], [ file(row[1][0], checkIfExists: true), file(row[1][1], checkIfExists: true) ] ] } - .ifEmpty { exit 1, 'params.input_paths was empty - no input files supplied' } - .into { ch_read_files_fastqc; ch_read_files_trimming } - } -} else { - Channel - .fromFilePairs(params.input, size: params.single_end ? 1 : 2) - .ifEmpty { exit 1, "Cannot find any reads matching: ${params.input}\nNB: Path needs to be enclosed in quotes!\nIf this is single-end data, please specify --single_end on the command line." } - .into { ch_read_files_fastqc; ch_read_files_trimming } -} - -//////////////////////////////////////////////////// -/* -- PRINT PARAMETER SUMMARY -- */ -//////////////////////////////////////////////////// -log.info NfcoreSchema.params_summary_log(workflow, params, json_schema) - -// Header log info -def summary = [:] -if (workflow.revision) summary['Pipeline Release'] = workflow.revision -summary['Run Name'] = workflow.runName -// TODO nf-core: Report custom parameters here -summary['Input'] = params.input -summary['Fasta Ref'] = params.fasta -summary['Data Type'] = params.single_end ? 'Single-End' : 'Paired-End' -summary['Max Resources'] = "$params.max_memory memory, $params.max_cpus cpus, $params.max_time time per job" -if (workflow.containerEngine) summary['Container'] = "$workflow.containerEngine - $workflow.container" -summary['Output dir'] = params.outdir -summary['Launch dir'] = workflow.launchDir -summary['Working dir'] = workflow.workDir -summary['Script dir'] = workflow.projectDir -summary['User'] = workflow.userName -if (workflow.profile.contains('awsbatch')) { - summary['AWS Region'] = params.awsregion - summary['AWS Queue'] = params.awsqueue - summary['AWS CLI'] = params.awscli -} -summary['Config Profile'] = workflow.profile -if (params.config_profile_description) summary['Config Profile Description'] = params.config_profile_description -if (params.config_profile_contact) summary['Config Profile Contact'] = params.config_profile_contact -if (params.config_profile_url) summary['Config Profile URL'] = params.config_profile_url -summary['Config Files'] = workflow.configFiles.join(', ') -if (params.email || params.email_on_fail) { - summary['E-mail Address'] = params.email - summary['E-mail on failure'] = params.email_on_fail - summary['MultiQC maxsize'] = params.max_multiqc_email_size -} - -// Check the hostnames against configured profiles -checkHostname() - -Channel.from(summary.collect{ [it.key, it.value] }) - .map { k,v -> "
$k
${v ?: 'N/A'}
" } - .reduce { a, b -> return [a, b].join("\n ") } - .map { x -> """ - id: 'nf-core-chipseq-summary' - description: " - this information is collected when the pipeline is started." - section_name: 'nf-core/chipseq Workflow Summary' - section_href: 'https://github.com/nf-core/chipseq' - plot_type: 'html' - data: | -
- $x -
- """.stripIndent() } - .set { ch_workflow_summary } - -/* - * Parse software version numbers - */ -process get_software_versions { - publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode, - saveAs: { filename -> - if (filename.indexOf('.csv') > 0) filename - else null - } - - output: - file 'software_versions_mqc.yaml' into ch_software_versions_yaml - file 'software_versions.csv' +======================================================================================== + GENOME PARAMETER VALUES +======================================================================================== +*/ - script: - // TODO nf-core: Get all tools to print their version number here - """ - echo $workflow.manifest.version > v_pipeline.txt - echo $workflow.nextflow.version > v_nextflow.txt - fastqc --version > v_fastqc.txt - multiqc --version > v_multiqc.txt - scrape_software_versions.py &> software_versions_mqc.yaml - """ -} +params.fasta = WorkflowMain.getGenomeAttribute(params, 'fasta') /* - * STEP 1 - FastQC - */ -process fastqc { - tag "$name" - label 'process_medium' - publishDir "${params.outdir}/fastqc", mode: params.publish_dir_mode, - saveAs: { filename -> - filename.indexOf('.zip') > 0 ? "zips/$filename" : "$filename" - } - - input: - set val(name), file(reads) from ch_read_files_fastqc - - output: - file '*_fastqc.{zip,html}' into ch_fastqc_results +======================================================================================== + VALIDATE & PRINT PARAMETER SUMMARY +======================================================================================== +*/ - script: - """ - fastqc --quiet --threads $task.cpus $reads - """ -} +WorkflowMain.initialise(workflow, params, log) /* - * STEP 2 - MultiQC - */ -process multiqc { - publishDir "${params.outdir}/MultiQC", mode: params.publish_dir_mode - - input: - file (multiqc_config) from ch_multiqc_config - file (mqc_custom_config) from ch_multiqc_custom_config.collect().ifEmpty([]) - // TODO nf-core: Add in log files from your new processes for MultiQC to find! - file ('fastqc/*') from ch_fastqc_results.collect().ifEmpty([]) - file ('software_versions/*') from ch_software_versions_yaml.collect() - file workflow_summary from ch_workflow_summary.collectFile(name: "workflow_summary_mqc.yaml") +======================================================================================== + NAMED WORKFLOW FOR PIPELINE +======================================================================================== +*/ - output: - file "*multiqc_report.html" into ch_multiqc_report - file "*_data" - file "multiqc_plots" +include { CHIPSEQ } from './workflows/chipseq' - script: - rtitle = '' - rfilename = '' - if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { - rtitle = "--title \"${workflow.runName}\"" - rfilename = "--filename " + workflow.runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" - } - custom_config_file = params.multiqc_config ? "--config $mqc_custom_config" : '' - // TODO nf-core: Specify which MultiQC modules to use with -m for a faster run time - """ - multiqc -f $rtitle $rfilename $custom_config_file . - """ +// +// WORKFLOW: Run main nf-core/chipseq analysis pipeline +// +workflow NFCORE_CHIPSEQ { + CHIPSEQ () } /* - * STEP 3 - Output Description HTML - */ -process output_documentation { - publishDir "${params.outdir}/pipeline_info", mode: params.publish_dir_mode - - input: - file output_docs from ch_output_docs - file images from ch_output_docs_images - - output: - file 'results_description.html' +======================================================================================== + RUN ALL WORKFLOWS +======================================================================================== +*/ - script: - """ - markdown_to_html.py $output_docs -o results_description.html - """ +// +// WORKFLOW: Execute a single named workflow for the pipeline +// See: https://github.com/nf-core/rnaseq/issues/619 +// +workflow { + NFCORE_CHIPSEQ () } /* - * Completion e-mail notification - */ -workflow.onComplete { - - // Set up the e-mail variables - def subject = "[nf-core/chipseq] Successful: $workflow.runName" - if (!workflow.success) { - subject = "[nf-core/chipseq] FAILED: $workflow.runName" - } - def email_fields = [:] - email_fields['version'] = workflow.manifest.version - email_fields['runName'] = workflow.runName - email_fields['success'] = workflow.success - email_fields['dateComplete'] = workflow.complete - email_fields['duration'] = workflow.duration - email_fields['exitStatus'] = workflow.exitStatus - email_fields['errorMessage'] = (workflow.errorMessage ?: 'None') - email_fields['errorReport'] = (workflow.errorReport ?: 'None') - email_fields['commandLine'] = workflow.commandLine - email_fields['projectDir'] = workflow.projectDir - email_fields['summary'] = summary - email_fields['summary']['Date Started'] = workflow.start - email_fields['summary']['Date Completed'] = workflow.complete - email_fields['summary']['Pipeline script file path'] = workflow.scriptFile - email_fields['summary']['Pipeline script hash ID'] = workflow.scriptId - if (workflow.repository) email_fields['summary']['Pipeline repository Git URL'] = workflow.repository - if (workflow.commitId) email_fields['summary']['Pipeline repository Git Commit'] = workflow.commitId - if (workflow.revision) email_fields['summary']['Pipeline Git branch/tag'] = workflow.revision - email_fields['summary']['Nextflow Version'] = workflow.nextflow.version - email_fields['summary']['Nextflow Build'] = workflow.nextflow.build - email_fields['summary']['Nextflow Compile Timestamp'] = workflow.nextflow.timestamp - - // TODO nf-core: If not using MultiQC, strip out this code (including params.max_multiqc_email_size) - // On success try attach the multiqc report - def mqc_report = null - try { - if (workflow.success) { - mqc_report = ch_multiqc_report.getVal() - if (mqc_report.getClass() == ArrayList) { - log.warn "[nf-core/chipseq] Found multiple reports from process 'multiqc', will use only one" - mqc_report = mqc_report[0] - } - } - } catch (all) { - log.warn "[nf-core/chipseq] Could not attach MultiQC report to summary email" - } - - // Check if we are only sending emails on failure - email_address = params.email - if (!params.email && params.email_on_fail && !workflow.success) { - email_address = params.email_on_fail - } - - // Render the TXT template - def engine = new groovy.text.GStringTemplateEngine() - def tf = new File("$projectDir/assets/email_template.txt") - def txt_template = engine.createTemplate(tf).make(email_fields) - def email_txt = txt_template.toString() - - // Render the HTML template - def hf = new File("$projectDir/assets/email_template.html") - def html_template = engine.createTemplate(hf).make(email_fields) - def email_html = html_template.toString() - - // Render the sendmail template - def smail_fields = [ email: email_address, subject: subject, email_txt: email_txt, email_html: email_html, projectDir: "$projectDir", mqcFile: mqc_report, mqcMaxSize: params.max_multiqc_email_size.toBytes() ] - def sf = new File("$projectDir/assets/sendmail_template.txt") - def sendmail_template = engine.createTemplate(sf).make(smail_fields) - def sendmail_html = sendmail_template.toString() - - // Send the HTML e-mail - if (email_address) { - try { - if (params.plaintext_email) { throw GroovyException('Send plaintext e-mail, not HTML') } - // Try to send HTML e-mail using sendmail - [ 'sendmail', '-t' ].execute() << sendmail_html - log.info "[nf-core/chipseq] Sent summary e-mail to $email_address (sendmail)" - } catch (all) { - // Catch failures and try with plaintext - def mail_cmd = [ 'mail', '-s', subject, '--content-type=text/html', email_address ] - if ( mqc_report.size() <= params.max_multiqc_email_size.toBytes() ) { - mail_cmd += [ '-A', mqc_report ] - } - mail_cmd.execute() << email_html - log.info "[nf-core/chipseq] Sent summary e-mail to $email_address (mail)" - } - } - - // Write summary e-mail HTML to a file - def output_d = new File("${params.outdir}/pipeline_info/") - if (!output_d.exists()) { - output_d.mkdirs() - } - def output_hf = new File(output_d, "pipeline_report.html") - output_hf.withWriter { w -> w << email_html } - def output_tf = new File(output_d, "pipeline_report.txt") - output_tf.withWriter { w -> w << email_txt } - - c_green = params.monochrome_logs ? '' : "\033[0;32m"; - c_purple = params.monochrome_logs ? '' : "\033[0;35m"; - c_red = params.monochrome_logs ? '' : "\033[0;31m"; - c_reset = params.monochrome_logs ? '' : "\033[0m"; - - if (workflow.stats.ignoredCount > 0 && workflow.success) { - log.info "-${c_purple}Warning, pipeline completed, but with errored process(es) ${c_reset}-" - log.info "-${c_red}Number of ignored errored process(es) : ${workflow.stats.ignoredCount} ${c_reset}-" - log.info "-${c_green}Number of successfully ran process(es) : ${workflow.stats.succeedCount} ${c_reset}-" - } - - if (workflow.success) { - log.info "-${c_purple}[nf-core/chipseq]${c_green} Pipeline completed successfully${c_reset}-" - } else { - checkHostname() - log.info "-${c_purple}[nf-core/chipseq]${c_red} Pipeline completed with errors${c_reset}-" - } - -} - -workflow.onError { - // Print unexpected parameters - easiest is to just rerun validation - NfcoreSchema.validateParameters(params, json_schema, log) -} - -def checkHostname() { - def c_reset = params.monochrome_logs ? '' : "\033[0m" - def c_white = params.monochrome_logs ? '' : "\033[0;37m" - def c_red = params.monochrome_logs ? '' : "\033[1;91m" - def c_yellow_bold = params.monochrome_logs ? '' : "\033[1;93m" - if (params.hostnames) { - def hostname = 'hostname'.execute().text.trim() - params.hostnames.each { prof, hnames -> - hnames.each { hname -> - if (hostname.contains(hname) && !workflow.profile.contains(prof)) { - log.error "${c_red}====================================================${c_reset}\n" + - " ${c_red}WARNING!${c_reset} You are running with `-profile $workflow.profile`\n" + - " but your machine hostname is ${c_white}'$hostname'${c_reset}\n" + - " ${c_yellow_bold}It's highly recommended that you use `-profile $prof${c_reset}`\n" + - "${c_red}====================================================${c_reset}\n" - } - } - } - } -} +======================================================================================== + THE END +======================================================================================== +*/ diff --git a/modules.json b/modules.json new file mode 100644 index 000000000..a11f8855c --- /dev/null +++ b/modules.json @@ -0,0 +1,14 @@ +{ + "name": "nf-core/chipseq", + "homePage": "https://github.com/nf-core/chipseq", + "repos": { + "nf-core/modules": { + "fastqc": { + "git_sha": "e937c7950af70930d1f34bb961403d9d2aa81c7d" + }, + "multiqc": { + "git_sha": "e937c7950af70930d1f34bb961403d9d2aa81c7d" + } + } + } +} diff --git a/modules/local/functions.nf b/modules/local/functions.nf new file mode 100644 index 000000000..da9da093d --- /dev/null +++ b/modules/local/functions.nf @@ -0,0 +1,68 @@ +// +// Utility functions used in nf-core DSL2 module files +// + +// +// Extract name of software tool from process name using $task.process +// +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +// +// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules +// +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.args3 = args.args3 ?: '' + options.publish_by_meta = args.publish_by_meta ?: [] + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files + options.suffix = args.suffix ?: '' + return options +} + +// +// Tidy up and join elements of a list to return a path string +// +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +// +// Function to save/publish module results +// +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_meta) { + def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta + for (key in key_list) { + if (args.meta && key instanceof String) { + def path = key + if (args.meta.containsKey(key)) { + path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] + } + path = path instanceof String ? path : '' + path_list.add(path) + } + } + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else if (ioptions.publish_files == null) { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/local/get_software_versions.nf b/modules/local/get_software_versions.nf new file mode 100644 index 000000000..3e9926b85 --- /dev/null +++ b/modules/local/get_software_versions.nf @@ -0,0 +1,33 @@ +// Import generic module functions +include { saveFiles } from './functions' + +params.options = [:] + +process GET_SOFTWARE_VERSIONS { + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'pipeline_info', meta:[:], publish_by_meta:[]) } + + conda (params.enable_conda ? "conda-forge::python=3.8.3" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://depot.galaxyproject.org/singularity/python:3.8.3" + } else { + container "quay.io/biocontainers/python:3.8.3" + } + + cache false + + input: + path versions + + output: + path "software_versions.tsv" , emit: tsv + path 'software_versions_mqc.yaml', emit: yaml + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + """ + echo $workflow.manifest.version > pipeline.version.txt + echo $workflow.nextflow.version > nextflow.version.txt + scrape_software_versions.py &> software_versions_mqc.yaml + """ +} diff --git a/modules/local/samplesheet_check.nf b/modules/local/samplesheet_check.nf new file mode 100644 index 000000000..b200e6ffb --- /dev/null +++ b/modules/local/samplesheet_check.nf @@ -0,0 +1,31 @@ +// Import generic module functions +include { saveFiles } from './functions' + +params.options = [:] + +process SAMPLESHEET_CHECK { + tag "$samplesheet" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'pipeline_info', meta:[:], publish_by_meta:[]) } + + conda (params.enable_conda ? "conda-forge::python=3.8.3" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://depot.galaxyproject.org/singularity/python:3.8.3" + } else { + container "quay.io/biocontainers/python:3.8.3" + } + + input: + path samplesheet + + output: + path '*.csv' + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + """ + check_samplesheet.py \\ + $samplesheet \\ + samplesheet.valid.csv + """ +} diff --git a/modules/nf-core/modules/fastqc/functions.nf b/modules/nf-core/modules/fastqc/functions.nf new file mode 100644 index 000000000..da9da093d --- /dev/null +++ b/modules/nf-core/modules/fastqc/functions.nf @@ -0,0 +1,68 @@ +// +// Utility functions used in nf-core DSL2 module files +// + +// +// Extract name of software tool from process name using $task.process +// +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +// +// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules +// +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.args3 = args.args3 ?: '' + options.publish_by_meta = args.publish_by_meta ?: [] + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files + options.suffix = args.suffix ?: '' + return options +} + +// +// Tidy up and join elements of a list to return a path string +// +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +// +// Function to save/publish module results +// +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_meta) { + def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta + for (key in key_list) { + if (args.meta && key instanceof String) { + def path = key + if (args.meta.containsKey(key)) { + path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] + } + path = path instanceof String ? path : '' + path_list.add(path) + } + } + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else if (ioptions.publish_files == null) { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/modules/fastqc/main.nf b/modules/nf-core/modules/fastqc/main.nf new file mode 100644 index 000000000..39c327b26 --- /dev/null +++ b/modules/nf-core/modules/fastqc/main.nf @@ -0,0 +1,47 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +params.options = [:] +options = initOptions(params.options) + +process FASTQC { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } + + conda (params.enable_conda ? "bioconda::fastqc=0.11.9" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0" + } else { + container "quay.io/biocontainers/fastqc:0.11.9--0" + } + + input: + tuple val(meta), path(reads) + + output: + tuple val(meta), path("*.html"), emit: html + tuple val(meta), path("*.zip") , emit: zip + path "*.version.txt" , emit: version + + script: + // Add soft-links to original FastQs for consistent naming in pipeline + def software = getSoftwareName(task.process) + def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + if (meta.single_end) { + """ + [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz + fastqc $options.args --threads $task.cpus ${prefix}.fastq.gz + fastqc --version | sed -e "s/FastQC v//g" > ${software}.version.txt + """ + } else { + """ + [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz + [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz + fastqc $options.args --threads $task.cpus ${prefix}_1.fastq.gz ${prefix}_2.fastq.gz + fastqc --version | sed -e "s/FastQC v//g" > ${software}.version.txt + """ + } +} diff --git a/modules/nf-core/modules/fastqc/meta.yml b/modules/nf-core/modules/fastqc/meta.yml new file mode 100644 index 000000000..8eb9953dc --- /dev/null +++ b/modules/nf-core/modules/fastqc/meta.yml @@ -0,0 +1,51 @@ +name: fastqc +description: Run FastQC on sequenced reads +keywords: + - quality control + - qc + - adapters + - fastq +tools: + - fastqc: + description: | + FastQC gives general quality metrics about your reads. + It provides information about the quality score distribution + across your reads, the per base sequence content (%A/C/G/T). + You get information about adapter contamination and other + overrepresented sequences. + homepage: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/ + documentation: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/ +input: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - reads: + type: file + description: | + List of input FastQ files of size 1 and 2 for single-end and paired-end data, + respectively. +output: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - html: + type: file + description: FastQC report + pattern: "*_{fastqc.html}" + - zip: + type: file + description: FastQC report archive + pattern: "*_{fastqc.zip}" + - version: + type: file + description: File containing software version + pattern: "*.{version.txt}" +authors: + - "@drpatelh" + - "@grst" + - "@ewels" + - "@FelixKrueger" diff --git a/modules/nf-core/modules/multiqc/functions.nf b/modules/nf-core/modules/multiqc/functions.nf new file mode 100644 index 000000000..da9da093d --- /dev/null +++ b/modules/nf-core/modules/multiqc/functions.nf @@ -0,0 +1,68 @@ +// +// Utility functions used in nf-core DSL2 module files +// + +// +// Extract name of software tool from process name using $task.process +// +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +// +// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules +// +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.args3 = args.args3 ?: '' + options.publish_by_meta = args.publish_by_meta ?: [] + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files + options.suffix = args.suffix ?: '' + return options +} + +// +// Tidy up and join elements of a list to return a path string +// +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +// +// Function to save/publish module results +// +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_meta) { + def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta + for (key in key_list) { + if (args.meta && key instanceof String) { + def path = key + if (args.meta.containsKey(key)) { + path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] + } + path = path instanceof String ? path : '' + path_list.add(path) + } + } + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else if (ioptions.publish_files == null) { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/modules/multiqc/main.nf b/modules/nf-core/modules/multiqc/main.nf new file mode 100644 index 000000000..da7808002 --- /dev/null +++ b/modules/nf-core/modules/multiqc/main.nf @@ -0,0 +1,35 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +params.options = [:] +options = initOptions(params.options) + +process MULTIQC { + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:[:], publish_by_meta:[]) } + + conda (params.enable_conda ? "bioconda::multiqc=1.10.1" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://depot.galaxyproject.org/singularity/multiqc:1.10.1--py_0" + } else { + container "quay.io/biocontainers/multiqc:1.10.1--py_0" + } + + input: + path multiqc_files + + output: + path "*multiqc_report.html", emit: report + path "*_data" , emit: data + path "*_plots" , optional:true, emit: plots + path "*.version.txt" , emit: version + + script: + def software = getSoftwareName(task.process) + """ + multiqc -f $options.args . + multiqc --version | sed -e "s/multiqc, version //g" > ${software}.version.txt + """ +} diff --git a/modules/nf-core/modules/multiqc/meta.yml b/modules/nf-core/modules/multiqc/meta.yml new file mode 100644 index 000000000..532a8bb1e --- /dev/null +++ b/modules/nf-core/modules/multiqc/meta.yml @@ -0,0 +1,39 @@ +name: MultiQC +description: Aggregate results from bioinformatics analyses across many samples into a single report +keywords: + - QC + - bioinformatics tools + - Beautiful stand-alone HTML report +tools: + - multiqc: + description: | + MultiQC searches a given directory for analysis logs and compiles a HTML report. + It's a general use tool, perfect for summarising the output from numerous bioinformatics tools. + homepage: https://multiqc.info/ + documentation: https://multiqc.info/docs/ +input: + - multiqc_files: + type: file + description: | + List of reports / files recognised by MultiQC, for example the html and zip output of FastQC +output: + - report: + type: file + description: MultiQC report file + pattern: "multiqc_report.html" + - data: + type: dir + description: MultiQC data dir + pattern: "multiqc_data" + - plots: + type: file + description: Plots created by MultiQC + pattern: "*_data" + - version: + type: file + description: File containing software version + pattern: "*.{version.txt}" +authors: + - "@abhi18av" + - "@bunop" + - "@drpatelh" diff --git a/nextflow.config b/nextflow.config index 1dd986558..4f7ea7561 100644 --- a/nextflow.config +++ b/nextflow.config @@ -1,130 +1,136 @@ /* - * ------------------------------------------------- - * nf-core/chipseq Nextflow config file - * ------------------------------------------------- - * Default config options for all environments. - */ +======================================================================================== + nf-core/chipseq Nextflow config file +======================================================================================== + Default config options for all compute environments +---------------------------------------------------------------------------------------- +*/ // Global default params, used in configs params { - // Workflow flags - // TODO nf-core: Specify your pipeline's command line flags - genome = false - input = null - input_paths = null - single_end = false - outdir = './results' - publish_dir_mode = 'copy' - - // Boilerplate options - multiqc_config = false - email = false - email_on_fail = false - max_multiqc_email_size = 25.MB - plaintext_email = false - monochrome_logs = false - help = false - igenomes_base = 's3://ngi-igenomes/igenomes' - tracedir = "${params.outdir}/pipeline_info" - igenomes_ignore = false - custom_config_version = 'master' - custom_config_base = "https://raw.githubusercontent.com/nf-core/configs/${params.custom_config_version}" - hostnames = false - config_profile_name = null - config_profile_description = false - config_profile_contact = false - config_profile_url = false - validate_params = true - show_hidden_params = false - schema_ignore_params = 'genomes,input_paths' - - // Defaults only, expecting to be overwritten - max_memory = 128.GB - max_cpus = 16 - max_time = 240.h + // TODO nf-core: Specify your pipeline's command line flags + // Input options + input = null -} + // References + genome = null + igenomes_base = 's3://ngi-igenomes/igenomes' + igenomes_ignore = false + + // MultiQC options + multiqc_config = null + multiqc_title = null + max_multiqc_email_size = '25.MB' + + // Boilerplate options + outdir = './results' + tracedir = "${params.outdir}/pipeline_info" + publish_dir_mode = 'copy' + email = null + email_on_fail = null + plaintext_email = false + monochrome_logs = false + help = false + validate_params = true + show_hidden_params = false + schema_ignore_params = 'genomes,modules' + enable_conda = false + singularity_pull_docker_container = false -// Container slug. Stable releases should specify release tag! -// Developmental code should specify :dev -process.container = 'nfcore/chipseq:dev' + // Config options + custom_config_version = 'master' + custom_config_base = "https://raw.githubusercontent.com/nf-core/configs/${params.custom_config_version}" + hostnames = [:] + config_profile_description = null + config_profile_contact = null + config_profile_url = null + config_profile_name = null + + // Max resource options + // Defaults only, expecting to be overwritten + max_memory = '128.GB' + max_cpus = 16 + max_time = '240.h' + +} // Load base.config by default for all pipelines includeConfig 'conf/base.config' +// Load modules.config for DSL2 module specific options +includeConfig 'conf/modules.config' + // Load nf-core custom profiles from different Institutions try { - includeConfig "${params.custom_config_base}/nfcore_custom.config" + includeConfig "${params.custom_config_base}/nfcore_custom.config" } catch (Exception e) { - System.err.println("WARNING: Could not load nf-core/config profiles: ${params.custom_config_base}/nfcore_custom.config") -} - -profiles { - conda { - docker.enabled = false - singularity.enabled = false - podman.enabled = false - shifter.enabled = false - charliecloud.enabled = false - process.conda = "$projectDir/environment.yml" - } - debug { process.beforeScript = 'echo $HOSTNAME' } - docker { - docker.enabled = true - singularity.enabled = false - podman.enabled = false - shifter.enabled = false - charliecloud.enabled = false - // Avoid this error: - // WARNING: Your kernel does not support swap limit capabilities or the cgroup is not mounted. Memory limited without swap. - // Testing this in nf-core after discussion here https://github.com/nf-core/tools/pull/351 - // once this is established and works well, nextflow might implement this behavior as new default. - docker.runOptions = '-u \$(id -u):\$(id -g)' - } - singularity { - docker.enabled = false - singularity.enabled = true - podman.enabled = false - shifter.enabled = false - charliecloud.enabled = false - singularity.autoMounts = true - } - podman { - singularity.enabled = false - docker.enabled = false - podman.enabled = true - shifter.enabled = false - charliecloud.enabled = false - } - shifter { - singularity.enabled = false - docker.enabled = false - podman.enabled = false - shifter.enabled = true - charliecloud.enabled = false - } - charliecloud { - singularity.enabled = false - docker.enabled = false - podman.enabled = false - shifter.enabled = false - charliecloud.enabled = true - } - test { includeConfig 'conf/test.config' } - test_full { includeConfig 'conf/test_full.config' } + System.err.println("WARNING: Could not load nf-core/config profiles: ${params.custom_config_base}/nfcore_custom.config") } // Load igenomes.config if required if (!params.igenomes_ignore) { - includeConfig 'conf/igenomes.config' + includeConfig 'conf/igenomes.config' +} else { + params.genomes = [:] +} + +profiles { + debug { process.beforeScript = 'echo $HOSTNAME' } + conda { + params.enable_conda = true + docker.enabled = false + singularity.enabled = false + podman.enabled = false + shifter.enabled = false + charliecloud.enabled = false + } + docker { + docker.enabled = true + docker.userEmulation = true + singularity.enabled = false + podman.enabled = false + shifter.enabled = false + charliecloud.enabled = false + } + singularity { + singularity.enabled = true + singularity.autoMounts = true + docker.enabled = false + podman.enabled = false + shifter.enabled = false + charliecloud.enabled = false + } + podman { + podman.enabled = true + docker.enabled = false + singularity.enabled = false + shifter.enabled = false + charliecloud.enabled = false + } + shifter { + shifter.enabled = true + docker.enabled = false + singularity.enabled = false + podman.enabled = false + charliecloud.enabled = false + } + charliecloud { + charliecloud.enabled = true + docker.enabled = false + singularity.enabled = false + podman.enabled = false + shifter.enabled = false + } + test { includeConfig 'conf/test.config' } + test_full { includeConfig 'conf/test_full.config' } } // Export these variables to prevent local Python/R libraries from conflicting with those in the container env { - PYTHONNOUSERSITE = 1 - R_PROFILE_USER = "/.Rprofile" - R_ENVIRON_USER = "/.Renviron" + PYTHONNOUSERSITE = 1 + R_PROFILE_USER = "/.Rprofile" + R_ENVIRON_USER = "/.Renviron" } // Capture exit codes from upstream processes when piping @@ -132,61 +138,61 @@ process.shell = ['/bin/bash', '-euo', 'pipefail'] def trace_timestamp = new java.util.Date().format( 'yyyy-MM-dd_HH-mm-ss') timeline { - enabled = true - file = "${params.tracedir}/execution_timeline_${trace_timestamp}.html" + enabled = true + file = "${params.tracedir}/execution_timeline_${trace_timestamp}.html" } report { - enabled = true - file = "${params.tracedir}/execution_report_${trace_timestamp}.html" + enabled = true + file = "${params.tracedir}/execution_report_${trace_timestamp}.html" } trace { - enabled = true - file = "${params.tracedir}/execution_trace_${trace_timestamp}.txt" + enabled = true + file = "${params.tracedir}/execution_trace_${trace_timestamp}.txt" } dag { - enabled = true - file = "${params.tracedir}/pipeline_dag_${trace_timestamp}.svg" + enabled = true + file = "${params.tracedir}/pipeline_dag_${trace_timestamp}.svg" } manifest { - name = 'nf-core/chipseq' - author = 'Philip Ewels' - homePage = 'https://github.com/nf-core/chipseq' - description = 'ChIP-seq peak-calling and differential analysis pipeline.' - mainScript = 'main.nf' - nextflowVersion = '>=20.04.0' - version = '1.3.0dev' + name = 'nf-core/chipseq' + author = 'Philip Ewels' + homePage = 'https://github.com/nf-core/chipseq' + description = 'ChIP-seq peak-calling and differential analysis pipeline.' + mainScript = 'main.nf' + nextflowVersion = '!>=21.04.0' + version = '1.3.0dev' } // Function to ensure that resource requirements don't go beyond // a maximum limit def check_max(obj, type) { - if (type == 'memory') { - try { - if (obj.compareTo(params.max_memory as nextflow.util.MemoryUnit) == 1) - return params.max_memory as nextflow.util.MemoryUnit - else - return obj - } catch (all) { - println " ### ERROR ### Max memory '${params.max_memory}' is not valid! Using default value: $obj" - return obj - } - } else if (type == 'time') { - try { - if (obj.compareTo(params.max_time as nextflow.util.Duration) == 1) - return params.max_time as nextflow.util.Duration - else - return obj - } catch (all) { - println " ### ERROR ### Max time '${params.max_time}' is not valid! Using default value: $obj" - return obj - } - } else if (type == 'cpus') { - try { - return Math.min( obj, params.max_cpus as int ) - } catch (all) { - println " ### ERROR ### Max cpus '${params.max_cpus}' is not valid! Using default value: $obj" - return obj + if (type == 'memory') { + try { + if (obj.compareTo(params.max_memory as nextflow.util.MemoryUnit) == 1) + return params.max_memory as nextflow.util.MemoryUnit + else + return obj + } catch (all) { + println " ### ERROR ### Max memory '${params.max_memory}' is not valid! Using default value: $obj" + return obj + } + } else if (type == 'time') { + try { + if (obj.compareTo(params.max_time as nextflow.util.Duration) == 1) + return params.max_time as nextflow.util.Duration + else + return obj + } catch (all) { + println " ### ERROR ### Max time '${params.max_time}' is not valid! Using default value: $obj" + return obj + } + } else if (type == 'cpus') { + try { + return Math.min( obj, params.max_cpus as int ) + } catch (all) { + println " ### ERROR ### Max cpus '${params.max_cpus}' is not valid! Using default value: $obj" + return obj + } } - } } diff --git a/nextflow_schema.json b/nextflow_schema.json index 278dfb9eb..b5a0526f6 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -16,19 +16,17 @@ "properties": { "input": { "type": "string", - "fa_icon": "fas fa-dna", - "description": "Input FastQ files.", - "help_text": "Use this to specify the location of your input FastQ files. For example:\n\n```bash\n--input 'path/to/data/sample_*_{1,2}.fastq'\n```\n\nPlease note the following requirements:\n\n1. The path must be enclosed in quotes\n2. The path must have at least one `*` wildcard character\n3. When using the pipeline with paired end data, the path must use `{1,2}` notation to specify read pairs.\n\nIf left unspecified, a default pattern is used: `data/*{1,2}.fastq.gz`" - }, - "single_end": { - "type": "boolean", - "description": "Specifies that the input is single-end reads.", - "fa_icon": "fas fa-align-center", - "help_text": "By default, the pipeline expects paired-end data. If you have single-end data, you need to specify `--single_end` on the command line when you launch the pipeline. A normal glob pattern, enclosed in quotation marks, can then be used for `--input`. For example:\n\n```bash\n--single_end --input '*.fastq'\n```\n\nIt is not possible to run a mixture of single-end and paired-end files in one run." + "format": "file-path", + "mimetype": "text/csv", + "pattern": "\\.csv$", + "schema": "assets/schema_input.json", + "description": "Path to comma-separated file containing information about the samples in the experiment.", + "help_text": "You will need to create a design file with information about the samples in your experiment before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 3 columns, and a header row. See [usage docs](https://nf-co.re/chipseq/usage#samplesheet-input).", + "fa_icon": "fas fa-file-csv" }, "outdir": { "type": "string", - "description": "The output directory where the results will be saved.", + "description": "Path to the output directory where the results will be saved.", "default": "./results", "fa_icon": "fas fa-folder-open" }, @@ -38,6 +36,11 @@ "fa_icon": "fas fa-envelope", "help_text": "Set this parameter to your e-mail address to get a summary e-mail with details of the run sent to you when the workflow exits. If set in your user config file (`~/.nextflow/config`) then you don't need to specify this on the command line for every run.", "pattern": "^([a-zA-Z0-9_\\-\\.]+)@([a-zA-Z0-9_\\-\\.]+)\\.([a-zA-Z]{2,5})$" + }, + "multiqc_title": { + "type": "string", + "description": "MultiQC report title. Printed as page header, used for filename if not otherwise specified.", + "fa_icon": "fas fa-file-signature" } } }, @@ -45,22 +48,26 @@ "title": "Reference genome options", "type": "object", "fa_icon": "fas fa-dna", - "description": "Options for the reference genome indices used to align reads.", + "description": "Reference genome related files and options required for the workflow.", "properties": { "genome": { "type": "string", "description": "Name of iGenomes reference.", "fa_icon": "fas fa-book", - "help_text": "If using a reference genome configured in the pipeline using iGenomes, use this parameter to give the ID for the reference. This is then used to build the full paths for all required reference genome files e.g. `--genome GRCh38`.\n\nSee the [nf-core website docs](https://nf-co.re/usage/reference_genomes) for more details." + "help_text": "If using a reference genome configured in the pipeline using iGenomes, use this parameter to give the ID for the reference. This is then used to build the full paths for all required reference genome files e.g. `--genome GRCh38`. \n\nSee the [nf-core website docs](https://nf-co.re/usage/reference_genomes) for more details." }, "fasta": { "type": "string", - "fa_icon": "fas fa-font", + "format": "file-path", + "mimetype": "text/plain", + "pattern": "\\.fn?a(sta)?(\\.gz)?$", "description": "Path to FASTA genome file.", - "help_text": "If you have no genome reference available, the pipeline can build one using a FASTA file. This requires additional time and resources, so it's better to use a pre-build index if possible." + "help_text": "This parameter is *mandatory* if `--genome` is not specified. If you don't have a BWA index available this will be generated for you automatically. Combine with `--save_reference` to save BWA index for future runs.", + "fa_icon": "far fa-file-code" }, "igenomes_base": { "type": "string", + "format": "directory-path", "description": "Directory / URL base for iGenomes references.", "default": "s3://ngi-igenomes/igenomes", "fa_icon": "fas fa-cloud-download-alt", @@ -75,91 +82,57 @@ } } }, - "generic_options": { - "title": "Generic options", + "institutional_config_options": { + "title": "Institutional config options", "type": "object", - "fa_icon": "fas fa-file-import", - "description": "Less common options for the pipeline, typically set in a config file.", - "help_text": "These options are common to all nf-core pipelines and allow you to customise some of the core preferences for how the pipeline runs.\n\nTypically these options would be set in a Nextflow config file loaded for all pipeline runs, such as `~/.nextflow/config`.", + "fa_icon": "fas fa-university", + "description": "Parameters used to describe centralised config profiles. These should not be edited.", + "help_text": "The centralised nf-core configuration profiles use a handful of pipeline parameters to describe themselves. This information is then printed to the Nextflow log when you run a pipeline. You should not need to change these values when you run a pipeline.", "properties": { - "help": { - "type": "boolean", - "description": "Display help text.", - "hidden": true, - "fa_icon": "fas fa-question-circle" - }, - "publish_dir_mode": { + "custom_config_version": { "type": "string", - "default": "copy", + "description": "Git commit id for Institutional configs.", + "default": "master", "hidden": true, - "description": "Method used to save pipeline results to output directory.", - "help_text": "The Nextflow `publishDir` option specifies which intermediate files should be saved to the output directory. This option tells the pipeline what method should be used to move these files. See [Nextflow docs](https://www.nextflow.io/docs/latest/process.html#publishdir) for details.", - "fa_icon": "fas fa-copy", - "enum": [ - "symlink", - "rellink", - "link", - "copy", - "copyNoFollow", - "move" - ] - }, - "validate_params": { - "type": "boolean", - "description": "Boolean whether to validate parameters against the schema at runtime", - "default": true, - "fa_icon": "fas fa-check-square", - "hidden": true + "fa_icon": "fas fa-users-cog" }, - "email_on_fail": { + "custom_config_base": { "type": "string", - "description": "Email address for completion summary, only when pipeline fails.", - "fa_icon": "fas fa-exclamation-triangle", - "pattern": "^([a-zA-Z0-9_\\-\\.]+)@([a-zA-Z0-9_\\-\\.]+)\\.([a-zA-Z]{2,5})$", + "description": "Base directory for Institutional configs.", + "default": "https://raw.githubusercontent.com/nf-core/configs/master", "hidden": true, - "help_text": "This works exactly as with `--email`, except emails are only sent if the workflow is not successful." + "help_text": "If you're running offline, Nextflow will not be able to fetch the institutional config files from the internet. If you don't need them, then this is not a problem. If you do need them, you should download the files from the repo and tell Nextflow where to find them with this parameter.", + "fa_icon": "fas fa-users-cog" }, - "plaintext_email": { - "type": "boolean", - "description": "Send plain-text email instead of HTML.", - "fa_icon": "fas fa-remove-format", + "hostnames": { + "type": "string", + "description": "Institutional configs hostname.", "hidden": true, - "help_text": "Set to receive plain-text e-mails instead of HTML formatted." + "fa_icon": "fas fa-users-cog" }, - "max_multiqc_email_size": { + "config_profile_name": { "type": "string", - "description": "File size limit when attaching MultiQC reports to summary emails.", - "default": "25.MB", - "fa_icon": "fas fa-file-upload", + "description": "Institutional config name.", "hidden": true, - "help_text": "If file generated by pipeline exceeds the threshold, it will not be attached." + "fa_icon": "fas fa-users-cog" }, - "monochrome_logs": { - "type": "boolean", - "description": "Do not use coloured log outputs.", - "fa_icon": "fas fa-palette", + "config_profile_description": { + "type": "string", + "description": "Institutional config description.", "hidden": true, - "help_text": "Set to disable colourful command line output and live life in monochrome." + "fa_icon": "fas fa-users-cog" }, - "multiqc_config": { + "config_profile_contact": { "type": "string", - "description": "Custom config file to supply to MultiQC.", - "fa_icon": "fas fa-cog", - "hidden": true + "description": "Institutional config contact information.", + "hidden": true, + "fa_icon": "fas fa-users-cog" }, - "tracedir": { + "config_profile_url": { "type": "string", - "description": "Directory to keep pipeline Nextflow logs and reports.", - "default": "${params.outdir}/pipeline_info", - "fa_icon": "fas fa-cogs", - "hidden": true - }, - "show_hidden_params": { - "type": "boolean", - "fa_icon": "far fa-eye-slash", - "description": "Show all params when using `--help`", + "description": "Institutional config URL link.", "hidden": true, - "help_text": "By default, parameters set as _hidden_ in the schema are not shown on the command line when a user runs with `--help`. Specifying this option will tell the pipeline to show all parameters." + "fa_icon": "fas fa-users-cog" } } }, @@ -172,7 +145,7 @@ "properties": { "max_cpus": { "type": "integer", - "description": "Maximum number of CPUs that can be requested for any single job.", + "description": "Maximum number of CPUs that can be requested for any single job.", "default": 16, "fa_icon": "fas fa-microchip", "hidden": true, @@ -198,58 +171,102 @@ } } }, - "institutional_config_options": { - "title": "Institutional config options", + "generic_options": { + "title": "Generic options", "type": "object", - "fa_icon": "fas fa-university", - "description": "Parameters used to describe centralised config profiles. These should not be edited.", - "help_text": "The centralised nf-core configuration profiles use a handful of pipeline parameters to describe themselves. This information is then printed to the Nextflow log when you run a pipeline. You should not need to change these values when you run a pipeline.", + "fa_icon": "fas fa-file-import", + "description": "Less common options for the pipeline, typically set in a config file.", + "help_text": "These options are common to all nf-core pipelines and allow you to customise some of the core preferences for how the pipeline runs.\n\nTypically these options would be set in a Nextflow config file loaded for all pipeline runs, such as `~/.nextflow/config`.", "properties": { - "custom_config_version": { + "help": { + "type": "boolean", + "description": "Display help text.", + "fa_icon": "fas fa-question-circle", + "hidden": true + }, + "publish_dir_mode": { "type": "string", - "description": "Git commit id for Institutional configs.", - "default": "master", - "hidden": true, - "fa_icon": "fas fa-users-cog", - "help_text": "Provide git commit id for custom Institutional configs hosted at `nf-core/configs`. This was implemented for reproducibility purposes. Default: `master`.\n\n```bash\n## Download and use config file with following git commit id\n--custom_config_version d52db660777c4bf36546ddb188ec530c3ada1b96\n```" + "default": "copy", + "description": "Method used to save pipeline results to output directory.", + "help_text": "The Nextflow `publishDir` option specifies which intermediate files should be saved to the output directory. This option tells the pipeline what method should be used to move these files. See [Nextflow docs](https://www.nextflow.io/docs/latest/process.html#publishdir) for details.", + "fa_icon": "fas fa-copy", + "enum": [ + "symlink", + "rellink", + "link", + "copy", + "copyNoFollow", + "move" + ], + "hidden": true }, - "custom_config_base": { + "email_on_fail": { "type": "string", - "description": "Base directory for Institutional configs.", - "default": "https://raw.githubusercontent.com/nf-core/configs/master", - "hidden": true, - "help_text": "If you're running offline, nextflow will not be able to fetch the institutional config files from the internet. If you don't need them, then this is not a problem. If you do need them, you should download the files from the repo and tell nextflow where to find them with the `custom_config_base` option. For example:\n\n```bash\n## Download and unzip the config files\ncd /path/to/my/configs\nwget https://github.com/nf-core/configs/archive/master.zip\nunzip master.zip\n\n## Run the pipeline\ncd /path/to/my/data\nnextflow run /path/to/pipeline/ --custom_config_base /path/to/my/configs/configs-master/\n```\n\n> Note that the nf-core/tools helper package has a `download` command to download all required pipeline files + singularity containers + institutional configs in one go for you, to make this process easier.", - "fa_icon": "fas fa-users-cog" + "description": "Email address for completion summary, only when pipeline fails.", + "fa_icon": "fas fa-exclamation-triangle", + "pattern": "^([a-zA-Z0-9_\\-\\.]+)@([a-zA-Z0-9_\\-\\.]+)\\.([a-zA-Z]{2,5})$", + "help_text": "An email address to send a summary email to when the pipeline is completed - ONLY sent if the pipeline does not exit successfully.", + "hidden": true }, - "hostnames": { + "plaintext_email": { + "type": "boolean", + "description": "Send plain-text email instead of HTML.", + "fa_icon": "fas fa-remove-format", + "hidden": true + }, + "max_multiqc_email_size": { "type": "string", - "description": "Institutional configs hostname.", - "hidden": true, - "fa_icon": "fas fa-users-cog" + "description": "File size limit when attaching MultiQC reports to summary emails.", + "pattern": "^\\d+(\\.\\d+)?\\.?\\s*(K|M|G|T)?B$", + "default": "25.MB", + "fa_icon": "fas fa-file-upload", + "hidden": true }, - "config_profile_name": { + "monochrome_logs": { + "type": "boolean", + "description": "Do not use coloured log outputs.", + "fa_icon": "fas fa-palette", + "hidden": true + }, + "multiqc_config": { "type": "string", - "description": "Institutional config name.", - "hidden": true, - "fa_icon": "fas fa-users-cog" + "description": "Custom config file to supply to MultiQC.", + "fa_icon": "fas fa-cog", + "hidden": true }, - "config_profile_description": { + "tracedir": { "type": "string", - "description": "Institutional config description.", + "description": "Directory to keep pipeline Nextflow logs and reports.", + "default": "${params.outdir}/pipeline_info", + "fa_icon": "fas fa-cogs", + "hidden": true + }, + "validate_params": { + "type": "boolean", + "description": "Boolean whether to validate parameters against the schema at runtime", + "default": true, + "fa_icon": "fas fa-check-square", + "hidden": true + }, + "show_hidden_params": { + "type": "boolean", + "fa_icon": "far fa-eye-slash", + "description": "Show all params when using `--help`", "hidden": true, - "fa_icon": "fas fa-users-cog" + "help_text": "By default, parameters set as _hidden_ in the schema are not shown on the command line when a user runs with `--help`. Specifying this option will tell the pipeline to show all parameters." }, - "config_profile_contact": { - "type": "string", - "description": "Institutional config contact information.", + "enable_conda": { + "type": "boolean", + "description": "Run this workflow with Conda. You can also use '-profile conda' instead of providing this parameter.", "hidden": true, - "fa_icon": "fas fa-users-cog" + "fa_icon": "fas fa-bacon" }, - "config_profile_url": { - "type": "string", - "description": "Institutional config URL link.", + "singularity_pull_docker_container": { + "type": "boolean", + "description": "Instead of directly downloading Singularity images for use with Singularity, force the workflow to pull and convert Docker containers instead.", "hidden": true, - "fa_icon": "fas fa-users-cog" + "fa_icon": "fas fa-toolbox", + "help_text": "This may be useful for example if you are unable to directly pull Singularity containers to run the pipeline due to http/https proxy issues." } } } @@ -262,13 +279,13 @@ "$ref": "#/definitions/reference_genome_options" }, { - "$ref": "#/definitions/generic_options" + "$ref": "#/definitions/institutional_config_options" }, { "$ref": "#/definitions/max_job_request_options" }, { - "$ref": "#/definitions/institutional_config_options" + "$ref": "#/definitions/generic_options" } ] } diff --git a/subworkflows/local/input_check.nf b/subworkflows/local/input_check.nf new file mode 100644 index 000000000..b664bc8ca --- /dev/null +++ b/subworkflows/local/input_check.nf @@ -0,0 +1,42 @@ +// +// Check input samplesheet and get read channels +// + +params.options = [:] + +include { SAMPLESHEET_CHECK } from '../../modules/local/samplesheet_check' addParams( options: params.options ) + +workflow INPUT_CHECK { + take: + samplesheet // file: /path/to/samplesheet.csv + + main: + SAMPLESHEET_CHECK ( samplesheet ) + .splitCsv ( header:true, sep:',' ) + .map { create_fastq_channels(it) } + .set { reads } + + emit: + reads // channel: [ val(meta), [ reads ] ] +} + +// Function to get list of [ meta, [ fastq_1, fastq_2 ] ] +def create_fastq_channels(LinkedHashMap row) { + def meta = [:] + meta.id = row.sample + meta.single_end = row.single_end.toBoolean() + + def array = [] + if (!file(row.fastq_1).exists()) { + exit 1, "ERROR: Please check input samplesheet -> Read 1 FastQ file does not exist!\n${row.fastq_1}" + } + if (meta.single_end) { + array = [ meta, [ file(row.fastq_1) ] ] + } else { + if (!file(row.fastq_2).exists()) { + exit 1, "ERROR: Please check input samplesheet -> Read 2 FastQ file does not exist!\n${row.fastq_2}" + } + array = [ meta, [ file(row.fastq_1), file(row.fastq_2) ] ] + } + return array +} diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf new file mode 100644 index 000000000..ea34de8bd --- /dev/null +++ b/workflows/chipseq.nf @@ -0,0 +1,141 @@ +/* +======================================================================================== + VALIDATE INPUTS +======================================================================================== +*/ + +def summary_params = NfcoreSchema.paramsSummaryMap(workflow, params) + +// Validate input parameters +WorkflowChipseq.initialise(params, log) + +// TODO nf-core: Add all file path parameters for the pipeline to the list below +// Check input path parameters to see if they exist +def checkPathParamList = [ params.input, params.multiqc_config, params.fasta ] +for (param in checkPathParamList) { if (param) { file(param, checkIfExists: true) } } + +// Check mandatory parameters +if (params.input) { ch_input = file(params.input) } else { exit 1, 'Input samplesheet not specified!' } + +/* +======================================================================================== + CONFIG FILES +======================================================================================== +*/ + +ch_multiqc_config = file("$projectDir/assets/multiqc_config.yaml", checkIfExists: true) +ch_multiqc_custom_config = params.multiqc_config ? Channel.fromPath(params.multiqc_config) : Channel.empty() + +/* +======================================================================================== + IMPORT LOCAL MODULES/SUBWORKFLOWS +======================================================================================== +*/ + +// Don't overwrite global params.modules, create a copy instead and use that within the main script. +def modules = params.modules.clone() + +// +// MODULE: Local to the pipeline +// +include { GET_SOFTWARE_VERSIONS } from '../modules/local/get_software_versions' addParams( options: [publish_files : ['tsv':'']] ) + +// +// SUBWORKFLOW: Consisting of a mix of local and nf-core/modules +// +include { INPUT_CHECK } from '../subworkflows/local/input_check' addParams( options: [:] ) + +/* +======================================================================================== + IMPORT NF-CORE MODULES/SUBWORKFLOWS +======================================================================================== +*/ + +def multiqc_options = modules['multiqc'] +multiqc_options.args += params.multiqc_title ? Utils.joinModuleArgs(["--title \"$params.multiqc_title\""]) : '' + +// +// MODULE: Installed directly from nf-core/modules +// +include { FASTQC } from '../modules/nf-core/modules/fastqc/main' addParams( options: modules['fastqc'] ) +include { MULTIQC } from '../modules/nf-core/modules/multiqc/main' addParams( options: multiqc_options ) + +/* +======================================================================================== + RUN MAIN WORKFLOW +======================================================================================== +*/ + +// Info required for completion email and summary +def multiqc_report = [] + +workflow CHIPSEQ { + + ch_software_versions = Channel.empty() + + // + // SUBWORKFLOW: Read in samplesheet, validate and stage input files + // + INPUT_CHECK ( + ch_input + ) + + // + // MODULE: Run FastQC + // + FASTQC ( + INPUT_CHECK.out.reads + ) + ch_software_versions = ch_software_versions.mix(FASTQC.out.version.first().ifEmpty(null)) + + // + // MODULE: Pipeline reporting + // + ch_software_versions + .map { it -> if (it) [ it.baseName, it ] } + .groupTuple() + .map { it[1][0] } + .flatten() + .collect() + .set { ch_software_versions } + + GET_SOFTWARE_VERSIONS ( + ch_software_versions.map { it }.collect() + ) + + // + // MODULE: MultiQC + // + workflow_summary = WorkflowChipseq.paramsSummaryMultiqc(workflow, summary_params) + ch_workflow_summary = Channel.value(workflow_summary) + + ch_multiqc_files = Channel.empty() + ch_multiqc_files = ch_multiqc_files.mix(Channel.from(ch_multiqc_config)) + ch_multiqc_files = ch_multiqc_files.mix(ch_multiqc_custom_config.collect().ifEmpty([])) + ch_multiqc_files = ch_multiqc_files.mix(ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml')) + ch_multiqc_files = ch_multiqc_files.mix(GET_SOFTWARE_VERSIONS.out.yaml.collect()) + ch_multiqc_files = ch_multiqc_files.mix(FASTQC.out.zip.collect{it[1]}.ifEmpty([])) + + MULTIQC ( + ch_multiqc_files.collect() + ) + multiqc_report = MULTIQC.out.report.toList() + ch_software_versions = ch_software_versions.mix(MULTIQC.out.version.ifEmpty(null)) +} + +/* +======================================================================================== + COMPLETION EMAIL AND SUMMARY +======================================================================================== +*/ + +workflow.onComplete { + NfcoreTemplate.email(workflow, params, summary_params, projectDir, log, multiqc_report) + NfcoreTemplate.summary(workflow, params, log) +} + +/* +======================================================================================== + THE END +======================================================================================== +*/ From ba3e7cbae3a05431b1e63078d3aea2ede2420c64 Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Tue, 13 Jul 2021 15:24:56 +0000 Subject: [PATCH 172/538] Template update for nf-core/tools version 2.0.1 --- .github/workflows/linting.yml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/.github/workflows/linting.yml b/.github/workflows/linting.yml index 13b4fc818..fbde5cf8b 100644 --- a/.github/workflows/linting.yml +++ b/.github/workflows/linting.yml @@ -127,7 +127,7 @@ jobs: GITHUB_COMMENTS_URL: ${{ github.event.pull_request.comments_url }} GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }} GITHUB_PR_COMMIT: ${{ github.event.pull_request.head.sha }} - run: nf-core -l lint_log.txt lint ${GITHUB_WORKSPACE} --markdown lint_results.md + run: nf-core -l lint_log.txt lint --dir ${GITHUB_WORKSPACE} --markdown lint_results.md - name: Save PR number if: ${{ always() }} From 176f9fbfecd2e11dc373dd947abb0be4448674f3 Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Tue, 27 Jul 2021 15:15:45 +0000 Subject: [PATCH 173/538] Template update for nf-core/tools version 2.1 --- .editorconfig | 3 +++ .github/CONTRIBUTING.md | 6 +++--- .github/PULL_REQUEST_TEMPLATE.md | 2 +- .github/workflows/linting.yml | 2 +- README.md | 2 +- bin/scrape_software_versions.py | 2 +- lib/NfcoreTemplate.groovy | 22 +++++++++++++--------- nextflow_schema.json | 4 ++-- workflows/chipseq.nf | 4 +++- 9 files changed, 28 insertions(+), 19 deletions(-) diff --git a/.editorconfig b/.editorconfig index afb20bb1e..95549501a 100644 --- a/.editorconfig +++ b/.editorconfig @@ -11,6 +11,9 @@ indent_style = space [*.{yml,yaml}] indent_size = 2 +[*.json] +insert_final_newline = unset + # These files are edited and tested upstream in nf-core/modules [/modules/nf-core/**] charset = unset diff --git a/.github/CONTRIBUTING.md b/.github/CONTRIBUTING.md index af4dba190..87854ad80 100644 --- a/.github/CONTRIBUTING.md +++ b/.github/CONTRIBUTING.md @@ -19,7 +19,7 @@ If you'd like to write some code for nf-core/chipseq, the standard workflow is a * If there isn't one already, please create one so that others know you're working on this 2. [Fork](https://help.github.com/en/github/getting-started-with-github/fork-a-repo) the [nf-core/chipseq repository](https://github.com/nf-core/chipseq) to your GitHub account 3. Make the necessary changes / additions within your forked repository following [Pipeline conventions](#pipeline-contribution-conventions) -4. Use `nf-core schema build .` and add any new parameters to the pipeline JSON schema (requires [nf-core tools](https://github.com/nf-core/tools) >= 1.10). +4. Use `nf-core schema build` and add any new parameters to the pipeline JSON schema (requires [nf-core tools](https://github.com/nf-core/tools) >= 1.10). 5. Submit a Pull Request against the `dev` branch and wait for the code to be reviewed and merged If you're not used to this workflow with git, you can start with some [docs from GitHub](https://help.github.com/en/github/collaborating-with-issues-and-pull-requests) or even their [excellent `git` resources](https://try.github.io/). @@ -69,7 +69,7 @@ If you wish to contribute a new step, please use the following coding standards: 2. Write the process block (see below). 3. Define the output channel if needed (see below). 4. Add any new flags/options to `nextflow.config` with a default (see below). -5. Add any new flags/options to `nextflow_schema.json` with help text (with `nf-core schema build .`). +5. Add any new flags/options to `nextflow_schema.json` with help text (with `nf-core schema build`). 6. Add any new flags/options to the help message (for integer/text parameters, print to help the corresponding `nextflow.config` parameter). 7. Add sanity checks for all relevant parameters. 8. Add any new software to the `scrape_software_versions.py` script in `bin/` and the version command to the `scrape_software_versions` process in `main.nf`. @@ -83,7 +83,7 @@ If you wish to contribute a new step, please use the following coding standards: Parameters should be initialised / defined with default values in `nextflow.config` under the `params` scope. -Once there, use `nf-core schema build .` to add to `nextflow_schema.json`. +Once there, use `nf-core schema build` to add to `nextflow_schema.json`. ### Default processes resource requirements diff --git a/.github/PULL_REQUEST_TEMPLATE.md b/.github/PULL_REQUEST_TEMPLATE.md index 8a29e2412..2f5f69256 100644 --- a/.github/PULL_REQUEST_TEMPLATE.md +++ b/.github/PULL_REQUEST_TEMPLATE.md @@ -18,7 +18,7 @@ Learn more about contributing: [CONTRIBUTING.md](https://github.com/nf-core/chip - [ ] If you've fixed a bug or added code that should be tested, add tests! - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) - [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. -- [ ] Make sure your code lints (`nf-core lint .`). +- [ ] Make sure your code lints (`nf-core lint`). - [ ] Ensure the test suite passes (`nextflow run . -profile test,docker`). - [ ] Usage Documentation in `docs/usage.md` is updated. - [ ] Output Documentation in `docs/output.md` is updated. diff --git a/.github/workflows/linting.yml b/.github/workflows/linting.yml index fbde5cf8b..3b448773c 100644 --- a/.github/workflows/linting.yml +++ b/.github/workflows/linting.yml @@ -53,7 +53,7 @@ jobs: - uses: actions/setup-node@v1 with: - node-version: "10" + node-version: '10' - name: Install editorconfig-checker run: npm install -g editorconfig-checker diff --git a/README.md b/README.md index 21f112264..72f3bfd11 100644 --- a/README.md +++ b/README.md @@ -33,7 +33,7 @@ On release, automated continuous integration tests run the pipeline on a full-si ## Quick Start -1. Install [`Nextflow`](https://nf-co.re/usage/installation) (`>=21.04.0`) +1. Install [`Nextflow`](https://www.nextflow.io/docs/latest/getstarted.html#installation) (`>=21.04.0`) 2. Install any of [`Docker`](https://docs.docker.com/engine/installation/), [`Singularity`](https://www.sylabs.io/guides/3.0/user-guide/), [`Podman`](https://podman.io/), [`Shifter`](https://nersc.gitlab.io/development/shifter/how-to-use/) or [`Charliecloud`](https://hpc.github.io/charliecloud/) for full pipeline reproducibility _(please only use [`Conda`](https://conda.io/miniconda.html) as a last resort; see [docs](https://nf-co.re/usage/configuration#basic-configuration-profiles))_ diff --git a/bin/scrape_software_versions.py b/bin/scrape_software_versions.py index 884897195..c060d8d5d 100755 --- a/bin/scrape_software_versions.py +++ b/bin/scrape_software_versions.py @@ -30,7 +30,7 @@ print("
{}
{}
".format(k, v)) print(" ") -# Write out regexes as csv file: +# Write out as tsv file: with open("software_versions.tsv", "w") as f: for k, v in sorted(results.items()): f.write("{}\t{}\n".format(k, v)) diff --git a/lib/NfcoreTemplate.groovy b/lib/NfcoreTemplate.groovy index b6e689ec8..44551e0a3 100755 --- a/lib/NfcoreTemplate.groovy +++ b/lib/NfcoreTemplate.groovy @@ -24,17 +24,21 @@ class NfcoreTemplate { public static void hostName(workflow, params, log) { Map colors = logColours(params.monochrome_logs) if (params.hostnames) { - def hostname = "hostname".execute().text.trim() - params.hostnames.each { prof, hnames -> - hnames.each { hname -> - if (hostname.contains(hname) && !workflow.profile.contains(prof)) { - log.info "=${colors.yellow}====================================================${colors.reset}=\n" + - "${colors.yellow}WARN: You are running with `-profile $workflow.profile`\n" + - " but your machine hostname is ${colors.white}'$hostname'${colors.reset}.\n" + - " ${colors.yellow_bold}Please use `-profile $prof${colors.reset}`\n" + - "=${colors.yellow}====================================================${colors.reset}=" + try { + def hostname = "hostname".execute().text.trim() + params.hostnames.each { prof, hnames -> + hnames.each { hname -> + if (hostname.contains(hname) && !workflow.profile.contains(prof)) { + log.info "=${colors.yellow}====================================================${colors.reset}=\n" + + "${colors.yellow}WARN: You are running with `-profile $workflow.profile`\n" + + " but your machine hostname is ${colors.white}'$hostname'${colors.reset}.\n" + + " ${colors.yellow_bold}Please use `-profile $prof${colors.reset}`\n" + + "=${colors.yellow}====================================================${colors.reset}=" + } } } + } catch (Exception e) { + log.warn "[$workflow.manifest.name] Could not determine 'hostname' - skipping check. Reason: ${e.message}." } } } diff --git a/nextflow_schema.json b/nextflow_schema.json index b5a0526f6..2c3b9f6e3 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -18,7 +18,7 @@ "type": "string", "format": "file-path", "mimetype": "text/csv", - "pattern": "\\.csv$", + "pattern": "^\\S+\\.csv$", "schema": "assets/schema_input.json", "description": "Path to comma-separated file containing information about the samples in the experiment.", "help_text": "You will need to create a design file with information about the samples in your experiment before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 3 columns, and a header row. See [usage docs](https://nf-co.re/chipseq/usage#samplesheet-input).", @@ -60,7 +60,7 @@ "type": "string", "format": "file-path", "mimetype": "text/plain", - "pattern": "\\.fn?a(sta)?(\\.gz)?$", + "pattern": "^\\S+\\.fn?a(sta)?(\\.gz)?$", "description": "Path to FASTA genome file.", "help_text": "This parameter is *mandatory* if `--genome` is not specified. If you don't have a BWA index available this will be generated for you automatically. Combine with `--save_reference` to save BWA index for future runs.", "fa_icon": "far fa-file-code" diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index ea34de8bd..46b8fb78f 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -130,7 +130,9 @@ workflow CHIPSEQ { */ workflow.onComplete { - NfcoreTemplate.email(workflow, params, summary_params, projectDir, log, multiqc_report) + if (params.email || params.email_on_fail) { + NfcoreTemplate.email(workflow, params, summary_params, projectDir, log, multiqc_report) + } NfcoreTemplate.summary(workflow, params, log) } From aa7e3c4c6679088e08934c9d70b28040037c12f4 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 9 Sep 2021 16:09:36 +0200 Subject: [PATCH 174/538] Merge remote-tracking branch 'upstream/nf-core-template-merge-2.1' into dev_merge_template_2.1 --- .editorconfig | 27 + .github/.dockstore.yml | 1 + .github/CONTRIBUTING.md | 10 +- .github/ISSUE_TEMPLATE/bug_report.md | 7 +- .github/ISSUE_TEMPLATE/feature_request.md | 2 +- .github/PULL_REQUEST_TEMPLATE.md | 8 +- .github/workflows/awsfulltest.yml | 45 +- .github/workflows/awstest.yml | 44 +- .github/workflows/branch.yml | 15 +- .github/workflows/ci.yml | 22 +- .github/workflows/linting.yml | 76 +- .github/workflows/push_dockerhub_dev.yml | 28 - .github/workflows/push_dockerhub_release.yml | 29 - .gitignore | 1 - .github/markdownlint.yml => .markdownlint.yml | 2 + CITATIONS.md | 213 ++--- CODE_OF_CONDUCT.md | 117 ++- Dockerfile | 17 - README.md | 46 +- assets/email_template.html | 1 - assets/samplesheet.csv | 3 + assets/schema_input.json | 39 + assets/sendmail_template.txt | 36 +- bin/scrape_software_versions.py | 32 +- conf/base.config | 84 +- conf/igenomes.config | 843 +++++++++--------- conf/modules.config | 38 +- conf/test.config | 21 +- conf/test_full.config | 29 +- docs/README.md | 4 +- docs/images/mqc_fastqc_adapter.png | Bin 0 -> 23458 bytes docs/images/mqc_fastqc_counts.png | Bin 0 -> 33918 bytes docs/images/mqc_fastqc_quality.png | Bin 0 -> 55769 bytes docs/output.md | 6 +- docs/usage.md | 208 ++++- environment.yml | 33 - lib/Checks.groovy | 47 - lib/NfcoreSchema.groovy | 517 +++++++++++ lib/NfcoreTemplate.groovy | 270 ++++++ lib/Utils.groovy | 47 + lib/WorkflowChipseq.groovy | 74 ++ lib/WorkflowMain.groovy | 94 ++ lib/nfcore_external_java_deps.jar | Bin 0 -> 2291171 bytes main.nf | 617 +------------ modules.json | 14 + modules/local/{process => }/bam_filter.nf | 94 +- .../local/{process => }/bam_remove_orphans.nf | 72 +- .../local/{process => }/bedtools_genomecov.nf | 92 +- .../{process => }/deseq2_featurecounts.nf | 110 +-- modules/local/{process => }/frip_score.nf | 56 +- modules/local/functions.nf | 68 ++ .../local/{process => }/get_chrom_sizes.nf | 68 +- modules/local/get_software_versions.nf | 33 + modules/local/{process => }/gtf2bed.nf | 60 +- modules/local/{process => }/igv.nf | 78 +- .../local/{process => }/macs2_consensus.nf | 110 +-- .../local/{process => }/make_genome_filter.nf | 82 +- modules/local/{process => }/multiqc.nf | 14 +- .../{process => }/multiqc_custom_peaks.nf | 60 +- .../multiqc_custom_phantompeakqualtools.nf | 70 +- .../{process => }/output_documentation.nf | 0 .../{process => }/plot_homer_annotatepeaks.nf | 72 +- modules/local/{process => }/plot_macs2_qc.nf | 64 +- modules/local/process/functions.nf | 59 -- .../local/process/get_software_versions.nf | 26 - modules/local/samplesheet_check.nf | 26 + modules/local/subworkflow/input_check.nf | 22 - .../mem => modules/bwa/index}/functions.nf | 118 +-- .../{software => modules}/bwa/index/main.nf | 0 .../{software => modules}/bwa/index/meta.yml | 0 .../fastqc => modules/bwa/mem}/functions.nf | 118 +-- .../{software => modules}/bwa/mem/main.nf | 84 +- .../{software => modules}/bwa/mem/meta.yml | 0 .../bwa/index => modules/fastqc}/functions.nf | 118 +-- .../{software => modules}/fastqc/main.nf | 0 .../{software => modules}/fastqc/meta.yml | 0 modules/nf-core/modules/multiqc/functions.nf | 68 ++ modules/nf-core/modules/multiqc/main.nf | 35 + modules/nf-core/modules/multiqc/meta.yml | 39 + .../collectmultiplemetrics/functions.nf | 118 +-- .../picard/collectmultiplemetrics/main.nf | 94 +- .../picard/markduplicates/functions.nf | 59 ++ .../picard/markduplicates/main.nf | 92 +- .../modules/picard/mergesamfiles/functions.nf | 59 ++ .../picard/mergesamfiles/main.nf | 102 +-- .../modules/samtools/flagstat/functions.nf | 59 ++ .../samtools/flagstat/main.nf | 58 +- .../modules/samtools/idxstats/functions.nf | 59 ++ .../samtools/idxstats/main.nf | 58 +- .../modules/samtools/index/functions.nf | 59 ++ .../samtools/index/main.nf | 58 +- .../samtools/index/meta.yml | 0 .../modules/samtools/sort/functions.nf | 59 ++ .../samtools/sort/main.nf | 64 +- .../samtools/sort/meta.yml | 0 .../modules/samtools/stats/functions.nf | 59 ++ .../samtools/stats/main.nf | 58 +- .../nf-core/modules/trimgalore/functions.nf | 59 ++ .../{software => modules}/trimgalore/main.nf | 158 ++-- .../{software => modules}/trimgalore/meta.yml | 0 .../picard/markduplicates/functions.nf | 59 -- .../picard/mergesamfiles/functions.nf | 59 -- .../software/samtools/flagstat/functions.nf | 59 -- .../software/samtools/idxstats/functions.nf | 59 -- .../software/samtools/index/functions.nf | 59 -- .../software/samtools/sort/functions.nf | 59 -- .../software/samtools/stats/functions.nf | 59 -- .../nf-core/software/trimgalore/functions.nf | 59 -- nextflow.config | 373 ++++---- nextflow_schema.json | 66 +- .../local}/bam_clean.nf | 66 +- .../local/input_check.nf | 44 +- .../nf-core}/bam_sort_samtools.nf | 53 +- .../nf-core}/bam_stats_samtools.nf | 48 +- .../nf-core}/fastqc_trimgalore.nf | 98 +- .../nf-core}/map_bwa_mem.nf | 56 +- .../nf-core}/mark_duplicates_picard.nf | 58 +- workflows/chipseq.nf | 628 +++++++++++++ 118 files changed, 5283 insertions(+), 3694 deletions(-) create mode 100644 .editorconfig delete mode 100644 .github/workflows/push_dockerhub_dev.yml delete mode 100644 .github/workflows/push_dockerhub_release.yml rename .github/markdownlint.yml => .markdownlint.yml (90%) delete mode 100644 Dockerfile create mode 100644 assets/samplesheet.csv create mode 100644 assets/schema_input.json create mode 100755 docs/images/mqc_fastqc_adapter.png create mode 100755 docs/images/mqc_fastqc_counts.png create mode 100755 docs/images/mqc_fastqc_quality.png delete mode 100644 environment.yml delete mode 100755 lib/Checks.groovy create mode 100755 lib/NfcoreSchema.groovy create mode 100755 lib/NfcoreTemplate.groovy create mode 100755 lib/Utils.groovy create mode 100755 lib/WorkflowChipseq.groovy create mode 100755 lib/WorkflowMain.groovy create mode 100644 lib/nfcore_external_java_deps.jar create mode 100644 modules.json rename modules/local/{process => }/bam_filter.nf (97%) rename modules/local/{process => }/bam_remove_orphans.nf (96%) rename modules/local/{process => }/bedtools_genomecov.nf (97%) rename modules/local/{process => }/deseq2_featurecounts.nf (97%) rename modules/local/{process => }/frip_score.nf (97%) create mode 100644 modules/local/functions.nf rename modules/local/{process => }/get_chrom_sizes.nf (96%) create mode 100644 modules/local/get_software_versions.nf rename modules/local/{process => }/gtf2bed.nf (96%) rename modules/local/{process => }/igv.nf (97%) rename modules/local/{process => }/macs2_consensus.nf (97%) rename modules/local/{process => }/make_genome_filter.nf (96%) rename modules/local/{process => }/multiqc.nf (83%) rename modules/local/{process => }/multiqc_custom_peaks.nf (97%) rename modules/local/{process => }/multiqc_custom_phantompeakqualtools.nf (97%) rename modules/local/{process => }/output_documentation.nf (100%) rename modules/local/{process => }/plot_homer_annotatepeaks.nf (96%) rename modules/local/{process => }/plot_macs2_qc.nf (96%) delete mode 100644 modules/local/process/functions.nf delete mode 100644 modules/local/process/get_software_versions.nf create mode 100644 modules/local/samplesheet_check.nf delete mode 100644 modules/local/subworkflow/input_check.nf rename modules/nf-core/{software/bwa/mem => modules/bwa/index}/functions.nf (97%) rename modules/nf-core/{software => modules}/bwa/index/main.nf (100%) rename modules/nf-core/{software => modules}/bwa/index/meta.yml (100%) rename modules/nf-core/{software/fastqc => modules/bwa/mem}/functions.nf (97%) rename modules/nf-core/{software => modules}/bwa/mem/main.nf (97%) rename modules/nf-core/{software => modules}/bwa/mem/meta.yml (100%) rename modules/nf-core/{software/bwa/index => modules/fastqc}/functions.nf (97%) rename modules/nf-core/{software => modules}/fastqc/main.nf (100%) rename modules/nf-core/{software => modules}/fastqc/meta.yml (100%) create mode 100644 modules/nf-core/modules/multiqc/functions.nf create mode 100644 modules/nf-core/modules/multiqc/main.nf create mode 100644 modules/nf-core/modules/multiqc/meta.yml rename modules/nf-core/{software => modules}/picard/collectmultiplemetrics/functions.nf (97%) rename modules/nf-core/{software => modules}/picard/collectmultiplemetrics/main.nf (97%) create mode 100644 modules/nf-core/modules/picard/markduplicates/functions.nf rename modules/nf-core/{software => modules}/picard/markduplicates/main.nf (97%) create mode 100644 modules/nf-core/modules/picard/mergesamfiles/functions.nf rename modules/nf-core/{software => modules}/picard/mergesamfiles/main.nf (97%) create mode 100644 modules/nf-core/modules/samtools/flagstat/functions.nf rename modules/nf-core/{software => modules}/samtools/flagstat/main.nf (97%) create mode 100644 modules/nf-core/modules/samtools/idxstats/functions.nf rename modules/nf-core/{software => modules}/samtools/idxstats/main.nf (97%) create mode 100644 modules/nf-core/modules/samtools/index/functions.nf rename modules/nf-core/{software => modules}/samtools/index/main.nf (97%) rename modules/nf-core/{software => modules}/samtools/index/meta.yml (100%) create mode 100644 modules/nf-core/modules/samtools/sort/functions.nf rename modules/nf-core/{software => modules}/samtools/sort/main.nf (97%) rename modules/nf-core/{software => modules}/samtools/sort/meta.yml (100%) create mode 100644 modules/nf-core/modules/samtools/stats/functions.nf rename modules/nf-core/{software => modules}/samtools/stats/main.nf (97%) create mode 100644 modules/nf-core/modules/trimgalore/functions.nf rename modules/nf-core/{software => modules}/trimgalore/main.nf (97%) rename modules/nf-core/{software => modules}/trimgalore/meta.yml (100%) delete mode 100644 modules/nf-core/software/picard/markduplicates/functions.nf delete mode 100644 modules/nf-core/software/picard/mergesamfiles/functions.nf delete mode 100644 modules/nf-core/software/samtools/flagstat/functions.nf delete mode 100644 modules/nf-core/software/samtools/idxstats/functions.nf delete mode 100644 modules/nf-core/software/samtools/index/functions.nf delete mode 100644 modules/nf-core/software/samtools/sort/functions.nf delete mode 100644 modules/nf-core/software/samtools/stats/functions.nf delete mode 100644 modules/nf-core/software/trimgalore/functions.nf rename {modules/local/subworkflow => subworkflows/local}/bam_clean.nf (80%) rename modules/local/process/samplesheet_check.nf => subworkflows/local/input_check.nf (53%) rename {modules/nf-core/subworkflow => subworkflows/nf-core}/bam_sort_samtools.nf (83%) rename {modules/nf-core/subworkflow => subworkflows/nf-core}/bam_stats_samtools.nf (73%) rename {modules/nf-core/subworkflow => subworkflows/nf-core}/fastqc_trimgalore.nf (90%) rename {modules/nf-core/subworkflow => subworkflows/nf-core}/map_bwa_mem.nf (93%) rename {modules/nf-core/subworkflow => subworkflows/nf-core}/mark_duplicates_picard.nf (88%) create mode 100644 workflows/chipseq.nf diff --git a/.editorconfig b/.editorconfig new file mode 100644 index 000000000..95549501a --- /dev/null +++ b/.editorconfig @@ -0,0 +1,27 @@ +root = true + +[*] +charset = utf-8 +end_of_line = lf +insert_final_newline = true +trim_trailing_whitespace = true +indent_size = 4 +indent_style = space + +[*.{yml,yaml}] +indent_size = 2 + +[*.json] +insert_final_newline = unset + +# These files are edited and tested upstream in nf-core/modules +[/modules/nf-core/**] +charset = unset +end_of_line = unset +insert_final_newline = unset +trim_trailing_whitespace = unset +indent_style = unset +indent_size = unset + +[/assets/email*] +indent_size = unset diff --git a/.github/.dockstore.yml b/.github/.dockstore.yml index 030138a0c..191fabd22 100644 --- a/.github/.dockstore.yml +++ b/.github/.dockstore.yml @@ -3,3 +3,4 @@ version: 1.2 workflows: - subclass: nfl primaryDescriptorPath: /nextflow.config + publish: True diff --git a/.github/CONTRIBUTING.md b/.github/CONTRIBUTING.md index 32de1a44b..87854ad80 100644 --- a/.github/CONTRIBUTING.md +++ b/.github/CONTRIBUTING.md @@ -19,7 +19,7 @@ If you'd like to write some code for nf-core/chipseq, the standard workflow is a * If there isn't one already, please create one so that others know you're working on this 2. [Fork](https://help.github.com/en/github/getting-started-with-github/fork-a-repo) the [nf-core/chipseq repository](https://github.com/nf-core/chipseq) to your GitHub account 3. Make the necessary changes / additions within your forked repository following [Pipeline conventions](#pipeline-contribution-conventions) -4. Use `nf-core schema build .` and add any new parameters to the pipeline JSON schema (requires [nf-core tools](https://github.com/nf-core/tools) >= 1.10). +4. Use `nf-core schema build` and add any new parameters to the pipeline JSON schema (requires [nf-core tools](https://github.com/nf-core/tools) >= 1.10). 5. Submit a Pull Request against the `dev` branch and wait for the code to be reviewed and merged If you're not used to this workflow with git, you can start with some [docs from GitHub](https://help.github.com/en/github/collaborating-with-issues-and-pull-requests) or even their [excellent `git` resources](https://try.github.io/). @@ -69,12 +69,12 @@ If you wish to contribute a new step, please use the following coding standards: 2. Write the process block (see below). 3. Define the output channel if needed (see below). 4. Add any new flags/options to `nextflow.config` with a default (see below). -5. Add any new flags/options to `nextflow_schema.json` with help text (with `nf-core schema build .`) +5. Add any new flags/options to `nextflow_schema.json` with help text (with `nf-core schema build`). 6. Add any new flags/options to the help message (for integer/text parameters, print to help the corresponding `nextflow.config` parameter). 7. Add sanity checks for all relevant parameters. 8. Add any new software to the `scrape_software_versions.py` script in `bin/` and the version command to the `scrape_software_versions` process in `main.nf`. 9. Do local tests that the new code works properly and as expected. -10. Add a new test command in `.github/workflow/ci.yaml`. +10. Add a new test command in `.github/workflow/ci.yml`. 11. If applicable add a [MultiQC](https://https://multiqc.info/) module. 12. Update MultiQC config `assets/multiqc_config.yaml` so relevant suffixes, name clean up, General Statistics Table column order, and module figures are in the right order. 13. Optional: Add any descriptions of MultiQC report sections and output files to `docs/output.md`. @@ -83,11 +83,11 @@ If you wish to contribute a new step, please use the following coding standards: Parameters should be initialised / defined with default values in `nextflow.config` under the `params` scope. -Once there, use `nf-core schema build .` to add to `nextflow_schema.json`. +Once there, use `nf-core schema build` to add to `nextflow_schema.json`. ### Default processes resource requirements -Sensible defaults for process resource requirements (CPUs / memory / time) for a process should be defined in `conf/base.config`. These should generally be specified generic with `withLabel:` selectors so they can be shared across multiple processes/steps of the pipeline. A nf-core standard set of labels that should be followed where possible can be seen in the [nf-core pipeline template](https://github.com/nf-core/tools/blob/master/nf_core/pipeline-template/%7B%7Bcookiecutter.name_noslash%7D%7D/conf/base.config), which has the default process as a single core-process, and then different levels of multi-core configurations for increasingly large memory requirements defined with standardised labels. +Sensible defaults for process resource requirements (CPUs / memory / time) for a process should be defined in `conf/base.config`. These should generally be specified generic with `withLabel:` selectors so they can be shared across multiple processes/steps of the pipeline. A nf-core standard set of labels that should be followed where possible can be seen in the [nf-core pipeline template](https://github.com/nf-core/tools/blob/master/nf_core/pipeline-template/conf/base.config), which has the default process as a single core-process, and then different levels of multi-core configurations for increasingly large memory requirements defined with standardised labels. The process resources can be passed on to the tool dynamically within the process with the `${task.cpu}` and `${task.memory}` variables in the `script:` block. diff --git a/.github/ISSUE_TEMPLATE/bug_report.md b/.github/ISSUE_TEMPLATE/bug_report.md index 7edcb791e..dbc527cc8 100644 --- a/.github/ISSUE_TEMPLATE/bug_report.md +++ b/.github/ISSUE_TEMPLATE/bug_report.md @@ -18,7 +18,7 @@ Please delete this text and anything that's not relevant from the template below I have checked the following places for your error: - [ ] [nf-core website: troubleshooting](https://nf-co.re/usage/troubleshooting) -- [ ] [nf-core/chipseq pipeline documentation](https://nf-co.re/nf-core/chipseq/usage) +- [ ] [nf-core/chipseq pipeline documentation](https://nf-co.re/chipseq/usage) ## Description of the bug @@ -51,13 +51,12 @@ Have you provided the following extra information/files: ## Nextflow Installation -- Version: +- Version: ## Container engine -- Engine: +- Engine: - version: -- Image tag: ## Additional context diff --git a/.github/ISSUE_TEMPLATE/feature_request.md b/.github/ISSUE_TEMPLATE/feature_request.md index 4a1e82612..15aceab96 100644 --- a/.github/ISSUE_TEMPLATE/feature_request.md +++ b/.github/ISSUE_TEMPLATE/feature_request.md @@ -1,6 +1,6 @@ --- name: Feature request -about: Suggest an idea for the nf-core website +about: Suggest an idea for the nf-core/chipseq pipeline labels: enhancement --- diff --git a/.github/PULL_REQUEST_TEMPLATE.md b/.github/PULL_REQUEST_TEMPLATE.md index f5062d15c..2f5f69256 100644 --- a/.github/PULL_REQUEST_TEMPLATE.md +++ b/.github/PULL_REQUEST_TEMPLATE.md @@ -10,15 +10,15 @@ Remember that PRs should be made against the dev branch, unless you're preparing Learn more about contributing: [CONTRIBUTING.md](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) --> + ## PR checklist - [ ] This comment contains a description of changes (with reason). - [ ] If you've fixed a bug or added code that should be tested, add tests! - - [ ] If you've added a new tool - add to the software_versions process and a regex to `scrape_software_versions.py` - - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) - - [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. -- [ ] Make sure your code lints (`nf-core lint .`). + - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) + - [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. +- [ ] Make sure your code lints (`nf-core lint`). - [ ] Ensure the test suite passes (`nextflow run . -profile test,docker`). - [ ] Usage Documentation in `docs/usage.md` is updated. - [ ] Output Documentation in `docs/output.md` is updated. diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index f7f79d355..3ce8292e1 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -1,39 +1,30 @@ name: nf-core AWS full size tests # This workflow is triggered on published releases. -# It can be additionally triggered manually with GitHub actions workflow dispatch. +# It can be additionally triggered manually with GitHub actions workflow dispatch button. # It runs the -profile 'test_full' on AWS batch on: - workflow_run: - workflows: ["nf-core Docker push (release)"] - types: [completed] + release: + types: [published] workflow_dispatch: - jobs: - run-awstest: + run-tower: name: Run AWS full tests if: github.repository == 'nf-core/chipseq' runs-on: ubuntu-latest steps: - - name: Setup Miniconda - uses: conda-incubator/setup-miniconda@v2 + - name: Launch workflow via tower + uses: nf-core/tower-action@master with: - auto-update-conda: true - python-version: 3.7 - - name: Install awscli - run: conda install -c conda-forge awscli - - name: Start AWS batch job - env: - AWS_ACCESS_KEY_ID: ${{ secrets.AWS_ACCESS_KEY_ID }} - AWS_SECRET_ACCESS_KEY: ${{ secrets.AWS_SECRET_ACCESS_KEY }} - TOWER_ACCESS_TOKEN: ${{ secrets.AWS_TOWER_TOKEN }} - AWS_JOB_DEFINITION: ${{ secrets.AWS_JOB_DEFINITION }} - AWS_JOB_QUEUE: ${{ secrets.AWS_JOB_QUEUE }} - AWS_S3_BUCKET: ${{ secrets.AWS_S3_BUCKET }} - run: | - aws batch submit-job \ - --region eu-west-1 \ - --job-name nf-core-chipseq \ - --job-queue $AWS_JOB_QUEUE \ - --job-definition $AWS_JOB_DEFINITION \ - --container-overrides '{"command": ["nf-core/chipseq", "-r '"${GITHUB_SHA}"' -profile test_full --outdir s3://'"${AWS_S3_BUCKET}"'/chipseq/results-'"${GITHUB_SHA}"' -w s3://'"${AWS_S3_BUCKET}"'/chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}' + workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }} + bearer_token: ${{ secrets.TOWER_BEARER_TOKEN }} + compute_env: ${{ secrets.TOWER_COMPUTE_ENV }} + pipeline: ${{ github.repository }} + revision: ${{ github.sha }} + workdir: s3://${{ secrets.AWS_S3_BUCKET }}/work/chipseq/work-${{ github.sha }} + parameters: | + { + "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-${{ github.sha }}" + } + profiles: '[ "test_full", "aws_tower" ]' + diff --git a/.github/workflows/awstest.yml b/.github/workflows/awstest.yml index 6fabf94aa..35a73e974 100644 --- a/.github/workflows/awstest.yml +++ b/.github/workflows/awstest.yml @@ -1,36 +1,28 @@ name: nf-core AWS test -# This workflow is triggered on push to the master branch. -# It can be additionally triggered manually with GitHub actions workflow dispatch. -# It runs the -profile 'test' on AWS batch. +# This workflow can be triggered manually with the GitHub actions workflow dispatch button. +# It runs the -profile 'test' on AWS batch on: workflow_dispatch: - jobs: - run-awstest: + run-tower: name: Run AWS tests if: github.repository == 'nf-core/chipseq' runs-on: ubuntu-latest steps: - - name: Setup Miniconda - uses: conda-incubator/setup-miniconda@v2 + - name: Launch workflow via tower + uses: nf-core/tower-action@master + with: - auto-update-conda: true - python-version: 3.7 - - name: Install awscli - run: conda install -c conda-forge awscli - - name: Start AWS batch job - env: - AWS_ACCESS_KEY_ID: ${{ secrets.AWS_ACCESS_KEY_ID }} - AWS_SECRET_ACCESS_KEY: ${{ secrets.AWS_SECRET_ACCESS_KEY }} - TOWER_ACCESS_TOKEN: ${{ secrets.AWS_TOWER_TOKEN }} - AWS_JOB_DEFINITION: ${{ secrets.AWS_JOB_DEFINITION }} - AWS_JOB_QUEUE: ${{ secrets.AWS_JOB_QUEUE }} - AWS_S3_BUCKET: ${{ secrets.AWS_S3_BUCKET }} - run: | - aws batch submit-job \ - --region eu-west-1 \ - --job-name nf-core-chipseq \ - --job-queue $AWS_JOB_QUEUE \ - --job-definition $AWS_JOB_DEFINITION \ - --container-overrides '{"command": ["nf-core/chipseq", "-r '"${GITHUB_SHA}"' -profile test --outdir s3://'"${AWS_S3_BUCKET}"'/chipseq/results-'"${GITHUB_SHA}"' -w s3://'"${AWS_S3_BUCKET}"'/chipseq/work-'"${GITHUB_SHA}"' -with-tower"], "environment": [{"name": "TOWER_ACCESS_TOKEN", "value": "'"$TOWER_ACCESS_TOKEN"'"}]}' + workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }} + bearer_token: ${{ secrets.TOWER_BEARER_TOKEN }} + compute_env: ${{ secrets.TOWER_COMPUTE_ENV }} + pipeline: ${{ github.repository }} + revision: ${{ github.sha }} + workdir: s3://${{ secrets.AWS_S3_BUCKET }}/work/chipseq/work-${{ github.sha }} + parameters: | + { + "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-${{ github.sha }}" + } + profiles: '[ "test", "aws_tower" ]' + diff --git a/.github/workflows/branch.yml b/.github/workflows/branch.yml index 17179b678..0615f2af9 100644 --- a/.github/workflows/branch.yml +++ b/.github/workflows/branch.yml @@ -13,7 +13,7 @@ jobs: - name: Check PRs if: github.repository == 'nf-core/chipseq' run: | - { [[ ${{github.event.pull_request.head.repo.full_name}} == nf-core/chipseq ]] && [[ $GITHUB_HEAD_REF = "dev" ]]; } || [[ $GITHUB_HEAD_REF == "patch" ]] + { [[ ${{github.event.pull_request.head.repo.full_name }} == nf-core/chipseq ]] && [[ $GITHUB_HEAD_REF = "dev" ]]; } || [[ $GITHUB_HEAD_REF == "patch" ]] # If the above check failed, post a comment on the PR explaining the failure @@ -23,13 +23,22 @@ jobs: uses: mshick/add-pr-comment@v1 with: message: | + ## This PR is against the `master` branch :x: + + * Do not close this PR + * Click _Edit_ and change the `base` to `dev` + * This CI test will remain failed until you push a new commit + + --- + Hi @${{ github.event.pull_request.user.login }}, - It looks like this pull-request is has been made against the ${{github.event.pull_request.head.repo.full_name}} `master` branch. + It looks like this pull-request is has been made against the [${{github.event.pull_request.head.repo.full_name }}](https://github.com/${{github.event.pull_request.head.repo.full_name }}) `master` branch. The `master` branch on nf-core repositories should always contain code from the latest release. - Because of this, PRs to `master` are only allowed if they come from the ${{github.event.pull_request.head.repo.full_name}} `dev` branch. + Because of this, PRs to `master` are only allowed if they come from the [${{github.event.pull_request.head.repo.full_name }}](https://github.com/${{github.event.pull_request.head.repo.full_name }}) `dev` branch. You do not need to close this PR, you can change the target branch to `dev` by clicking the _"Edit"_ button at the top of this page. + Note that even after this, the test will continue to show as failing until you push a new commit. Thanks again for your contribution! repo-token: ${{ secrets.GITHUB_TOKEN }} diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index ef018c0d4..f674c065d 100755 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -8,6 +8,9 @@ on: release: types: [published] +# Uncomment if we need an edge release of Nextflow again +# env: NXF_EDGE: 1 + jobs: test: name: Run workflow tests @@ -20,28 +23,11 @@ jobs: strategy: matrix: # Nextflow versions: check pipeline minimum and current latest - nxf_ver: ['20.07.1', ''] + nxf_ver: ['21.04.0', ''] steps: - name: Check out pipeline code uses: actions/checkout@v2 - - name: Check if Dockerfile or Conda environment changed - uses: technote-space/get-diff-action@v4 - with: - FILES: | - Dockerfile - environment.yml - - - name: Build new docker image - if: env.MATCHED_FILES - run: docker build --no-cache . -t nfcore/chipseq:dev - - - name: Pull docker image - if: ${{ !env.MATCHED_FILES }} - run: | - docker pull nfcore/chipseq:dev - docker tag nfcore/chipseq:dev nfcore/chipseq:dev - - name: Install Nextflow env: CAPSULE_LOG: none diff --git a/.github/workflows/linting.yml b/.github/workflows/linting.yml index bef81e619..3b448773c 100755 --- a/.github/workflows/linting.yml +++ b/.github/workflows/linting.yml @@ -18,7 +18,49 @@ jobs: - name: Install markdownlint run: npm install -g markdownlint-cli - name: Run Markdownlint - run: markdownlint ${GITHUB_WORKSPACE} -c ${GITHUB_WORKSPACE}/.github/markdownlint.yml + run: markdownlint . + + # If the above check failed, post a comment on the PR explaining the failure + - name: Post PR comment + if: failure() + uses: mshick/add-pr-comment@v1 + with: + message: | + ## Markdown linting is failing + + To keep the code consistent with lots of contributors, we run automated code consistency checks. + To fix this CI test, please run: + + * Install `markdownlint-cli` + * On Mac: `brew install markdownlint-cli` + * Everything else: [Install `npm`](https://www.npmjs.com/get-npm) then [install `markdownlint-cli`](https://www.npmjs.com/package/markdownlint-cli) (`npm install -g markdownlint-cli`) + * Fix the markdown errors + * Automatically: `markdownlint . --fix` + * Manually resolve anything left from `markdownlint .` + + Once you push these changes the test should pass, and you can hide this comment :+1: + + We highly recommend setting up markdownlint in your code editor so that this formatting is done automatically on save. Ask about it on Slack for help! + + Thanks again for your contribution! + repo-token: ${{ secrets.GITHUB_TOKEN }} + allow-repeats: false + + EditorConfig: + runs-on: ubuntu-latest + steps: + - uses: actions/checkout@v2 + + - uses: actions/setup-node@v1 + with: + node-version: '10' + + - name: Install editorconfig-checker + run: npm install -g editorconfig-checker + + - name: Run ECLint check + run: editorconfig-checker -exclude README.md $(git ls-files | grep -v test) + YAML: runs-on: ubuntu-latest steps: @@ -29,7 +71,33 @@ jobs: - name: Install yaml-lint run: npm install -g yaml-lint - name: Run yaml-lint - run: yamllint $(find ${GITHUB_WORKSPACE} -type f -name "*.yml") + run: yamllint $(find ${GITHUB_WORKSPACE} -type f -name "*.yml" -o -name "*.yaml") + + # If the above check failed, post a comment on the PR explaining the failure + - name: Post PR comment + if: failure() + uses: mshick/add-pr-comment@v1 + with: + message: | + ## YAML linting is failing + + To keep the code consistent with lots of contributors, we run automated code consistency checks. + To fix this CI test, please run: + + * Install `yaml-lint` + * [Install `npm`](https://www.npmjs.com/get-npm) then [install `yaml-lint`](https://www.npmjs.com/package/yaml-lint) (`npm install -g yaml-lint`) + * Fix the markdown errors + * Run the test locally: `yamllint $(find . -type f -name "*.yml" -o -name "*.yaml")` + * Fix any reported errors in your YAML files + + Once you push these changes the test should pass, and you can hide this comment :+1: + + We highly recommend setting up yaml-lint in your code editor so that this formatting is done automatically on save. Ask about it on Slack for help! + + Thanks again for your contribution! + repo-token: ${{ secrets.GITHUB_TOKEN }} + allow-repeats: false + nf-core: runs-on: ubuntu-latest steps: @@ -59,7 +127,7 @@ jobs: GITHUB_COMMENTS_URL: ${{ github.event.pull_request.comments_url }} GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }} GITHUB_PR_COMMIT: ${{ github.event.pull_request.head.sha }} - run: nf-core -l lint_log.txt lint ${GITHUB_WORKSPACE} --markdown lint_results.md + run: nf-core -l lint_log.txt lint --dir ${GITHUB_WORKSPACE} --markdown lint_results.md - name: Save PR number if: ${{ always() }} @@ -69,7 +137,7 @@ jobs: if: ${{ always() }} uses: actions/upload-artifact@v2 with: - name: linting-log-file + name: linting-logs path: | lint_log.txt lint_results.md diff --git a/.github/workflows/push_dockerhub_dev.yml b/.github/workflows/push_dockerhub_dev.yml deleted file mode 100644 index 828dc0fa8..000000000 --- a/.github/workflows/push_dockerhub_dev.yml +++ /dev/null @@ -1,28 +0,0 @@ -name: nf-core Docker push (dev) -# This builds the docker image and pushes it to DockerHub -# Runs on nf-core repo releases and push event to 'dev' branch (PR merges) -on: - push: - branches: - - dev - -jobs: - push_dockerhub: - name: Push new Docker image to Docker Hub (dev) - runs-on: ubuntu-latest - # Only run for the nf-core repo, for releases and merged PRs - if: ${{ github.repository == 'nf-core/chipseq' }} - env: - DOCKERHUB_USERNAME: ${{ secrets.DOCKERHUB_USERNAME }} - DOCKERHUB_PASS: ${{ secrets.DOCKERHUB_PASS }} - steps: - - name: Check out pipeline code - uses: actions/checkout@v2 - - - name: Build new docker image - run: docker build --no-cache . -t nfcore/chipseq:dev - - - name: Push Docker image to DockerHub (dev) - run: | - echo "$DOCKERHUB_PASS" | docker login -u "$DOCKERHUB_USERNAME" --password-stdin - docker push nfcore/chipseq:dev diff --git a/.github/workflows/push_dockerhub_release.yml b/.github/workflows/push_dockerhub_release.yml deleted file mode 100644 index 69cfe042a..000000000 --- a/.github/workflows/push_dockerhub_release.yml +++ /dev/null @@ -1,29 +0,0 @@ -name: nf-core Docker push (release) -# This builds the docker image and pushes it to DockerHub -# Runs on nf-core repo releases and push event to 'dev' branch (PR merges) -on: - release: - types: [published] - -jobs: - push_dockerhub: - name: Push new Docker image to Docker Hub (release) - runs-on: ubuntu-latest - # Only run for the nf-core repo, for releases and merged PRs - if: ${{ github.repository == 'nf-core/chipseq' }} - env: - DOCKERHUB_USERNAME: ${{ secrets.DOCKERHUB_USERNAME }} - DOCKERHUB_PASS: ${{ secrets.DOCKERHUB_PASS }} - steps: - - name: Check out pipeline code - uses: actions/checkout@v2 - - - name: Build new docker image - run: docker build --no-cache . -t nfcore/chipseq:latest - - - name: Push Docker image to DockerHub (release) - run: | - echo "$DOCKERHUB_PASS" | docker login -u "$DOCKERHUB_USERNAME" --password-stdin - docker push nfcore/chipseq:latest - docker tag nfcore/chipseq:latest nfcore/chipseq:${{ github.event.release.tag_name }} - docker push nfcore/chipseq:${{ github.event.release.tag_name }} diff --git a/.gitignore b/.gitignore index aa4bb5b37..5124c9ac7 100644 --- a/.gitignore +++ b/.gitignore @@ -3,7 +3,6 @@ work/ data/ results/ .DS_Store -tests/ testing/ testing* *.pyc diff --git a/.github/markdownlint.yml b/.markdownlint.yml similarity index 90% rename from .github/markdownlint.yml rename to .markdownlint.yml index 8d7eb53b0..9e605fcfa 100644 --- a/.github/markdownlint.yml +++ b/.markdownlint.yml @@ -1,6 +1,8 @@ # Markdownlint configuration file default: true line-length: false +ul-indent: + indent: 4 no-duplicate-header: siblings_only: true no-inline-html: diff --git a/CITATIONS.md b/CITATIONS.md index eb5a5405e..bae3ea84f 100644 --- a/CITATIONS.md +++ b/CITATIONS.md @@ -1,106 +1,107 @@ -# nf-core/chipseq: Citations - -## [nf-core](https://www.ncbi.nlm.nih.gov/pubmed/32055031/) - -> Ewels PA, Peltzer A, Fillinger S, Patel H, Alneberg J, Wilm A, Garcia MU, Di Tommaso P, Nahnsen S. The nf-core framework for community-curated bioinformatics pipelines. Nat Biotechnol. 2020 Mar;38(3):276-278. doi: 10.1038/s41587-020-0439-x. PubMed PMID: 32055031. - -## [Nextflow](https://www.ncbi.nlm.nih.gov/pubmed/28398311/) - -> Di Tommaso P, Chatzou M, Floden EW, Barja PP, Palumbo E, Notredame C. Nextflow enables reproducible computational workflows. Nat Biotechnol. 2017 Apr 11;35(4):316-319. doi: 10.1038/nbt.3820. PubMed PMID: 28398311. - -## Pipeline tools - -* [BWA](https://www.ncbi.nlm.nih.gov/pubmed/19451168/) - > Li H, Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 2009 Jul 15;25(14):1754-60. doi: 10.1093/bioinformatics/btp324. Epub 2009 May 18. PubMed PMID: 19451168; PubMed Central PMCID: PMC2705234. - -* [BEDTools](https://www.ncbi.nlm.nih.gov/pubmed/20110278/) - > Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010 Mar 15;26(6):841-2. doi: 10.1093/bioinformatics/btq033. Epub 2010 Jan 28. PubMed PMID: 20110278; PubMed Central PMCID: PMC2832824. - -* [SAMtools](https://www.ncbi.nlm.nih.gov/pubmed/19505943/) - > Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R; 1000 Genome Project Data Processing Subgroup. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 2009 Aug 15;25(16):2078-9. doi: 10.1093/bioinformatics/btp352. Epub 2009 Jun 8. PubMed PMID: 19505943; PubMed Central PMCID: PMC2723002. - -* [BamTools](https://www.ncbi.nlm.nih.gov/pubmed/21493652/) - > Barnett DW, Garrison EK, Quinlan AR, Strömberg MP, Marth GT. BamTools: a C++ API and toolkit for analyzing and managing BAM files. Bioinformatics. 2011 Jun 15;27(12):1691-2. doi: 10.1093/bioinformatics/btr174. Epub 2011 Apr 14. PubMed PMID: 21493652; PubMed Central PMCID: PMC3106182. - -* [UCSC tools](https://www.ncbi.nlm.nih.gov/pubmed/20639541/) - > Kent WJ, Zweig AS, Barber G, Hinrichs AS, Karolchik D. BigWig and BigBed: enabling browsing of large distributed datasets. Bioinformatics. 2010 Sep 1;26(17):2204-7. doi: 10.1093/bioinformatics/btq351. Epub 2010 Jul 17. PubMed PMID: 20639541; PubMed Central PMCID: PMC2922891. - -* [preseq](https://www.ncbi.nlm.nih.gov/pubmed/23435259/) - > Daley T, Smith AD. Predicting the molecular complexity of sequencing libraries. Nat Methods. 2013 Apr;10(4):325-7. doi: 10.1038/nmeth.2375. Epub 2013 Feb 24. PubMed PMID: 23435259; PubMed Central PMCID: PMC3612374. - -* [deepTools](https://www.ncbi.nlm.nih.gov/pubmed/27079975/) - > Ramírez F, Ryan DP, Grüning B, Bhardwaj V, Kilpert F, Richter AS, Heyne S, Dündar F, Manke T. deepTools2: a next generation web server for deep-sequencing data analysis. Nucleic Acids Res. 2016 Jul 8;44(W1):W160-5. doi: 10.1093/nar/gkw257. Epub 2016 Apr 13. PubMed PMID: 27079975; PubMed Central PMCID: PMC4987876. - -* [MACS2](https://www.ncbi.nlm.nih.gov/pubmed/18798982/) - > Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W, Liu XS. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008;9(9):R137. doi: 10.1186/gb-2008-9-9-r137. Epub 2008 Sep 17. PubMed PMID: 18798982; PubMed Central PMCID: PMC2592715. - -* [HOMER](https://www.ncbi.nlm.nih.gov/pubmed/20513432/) - > Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010 May 28;38(4):576-89. doi: 10.1016/j.molcel.2010.05.004. PubMed PMID: 20513432; PubMed Central PMCID: PMC2898526. - -* [phantompeakqualtools](https://www.ncbi.nlm.nih.gov/pubmed/22955991/) - > Landt SG, Marinov GK, Kundaje A, Kheradpour P, Pauli F, Batzoglou S, Bernstein BE, Bickel P, Brown JB, Cayting P, Chen Y, DeSalvo G, Epstein C, Fisher-Aylor KI, Euskirchen G, Gerstein M, Gertz J, Hartemink AJ, Hoffman MM, Iyer VR, Jung YL, Karmakar S, Kellis M, Kharchenko PV, Li Q, Liu T, Liu XS, Ma L, Milosavljevic A, Myers RM, Park PJ, Pazin MJ, Perry MD, Raha D, Reddy TE, Rozowsky J, Shoresh N, Sidow A, Slattery M, Stamatoyannopoulos JA, Tolstorukov MY, White KP, Xi S, Farnham PJ, Lieb JD, Wold BJ, Snyder M. ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res. 2012 Sep;22(9):1813-31. doi: 10.1101/gr.136184.111. PubMed PMID: 22955991; PubMed Central PMCID: PMC3431496. - -* [featureCounts](https://www.ncbi.nlm.nih.gov/pubmed/24227677/) - > Liao Y, Smyth GK, Shi W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014 Apr 1;30(7):923-30. doi: 10.1093/bioinformatics/btt656. Epub 2013 Nov 13. PubMed PMID: 24227677. - -* [MultiQC](https://www.ncbi.nlm.nih.gov/pubmed/27312411/) - > Ewels P, Magnusson M, Lundin S, Käller M. MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics. 2016 Oct 1;32(19):3047-8. doi: 10.1093/bioinformatics/btw354. Epub 2016 Jun 16. PubMed PMID: 27312411; PubMed Central PMCID: PMC5039924. - -* [FastQC](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/) - -* [Trim Galore!](https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/) - -* [picard-tools](http://broadinstitute.github.io/picard) - -* [pysam](https://github.com/pysam-developers/pysam) - -## R packages - -* [R](https://www.R-project.org/) - > R Core Team (2017). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. - -* [DESeq2](https://www.ncbi.nlm.nih.gov/pubmed/25516281/) - > Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550. PubMed PMID: 25516281; PubMed Central PMCID: PMC4302049. - -* [vsn](https://bioconductor.org/packages/release/bioc/html/vsn.html) - > Wolfgang Huber, Anja von Heydebreck, Holger Sueltmann, Annemarie Poustka and Martin Vingron. Variance Stabilization Applied to Microarray Data Calibration and to the Quantification of Differential Expression. Bioinformatics 18, S96-S104 (2002). - -* [UpSetR](https://CRAN.R-project.org/package=UpSetR) - > Nils Gehlenborg (2017). UpSetR: A More Scalable Alternative to Venn and Euler Diagrams for Visualizing Intersecting Sets. - -* [ggplot2](https://cran.r-project.org/web/packages/ggplot2/index.html) - > H. Wickham. ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag New York, 2016. - -* [reshape2](http://www.jstatsoft.org/v21/i12/) - > Hadley Wickham (2007). Reshaping Data with the reshape Package. Journal of Statistical Software, 21(12), 1-20. - -* [scales](https://CRAN.R-project.org/package=scales) - > Hadley Wickham (2018). scales: Scale Functions for Visualization. - -* [pheatmap](https://CRAN.R-project.org/package=pheatmap) - > Raivo Kolde (2018). pheatmap: Pretty Heatmaps. - -* [lattice](https://cran.r-project.org/web/packages/lattice/index.html) - > Sarkar, Deepayan (2008) Lattice: Multivariate Data Visualization with R. Springer, New York. ISBN 978-0-387-75968-5. - -* [RColorBrewer](https://CRAN.R-project.org/package=RColorBrewer) - > Erich Neuwirth (2014). RColorBrewer: ColorBrewer Palettes. - -* [optparse](https://CRAN.R-project.org/package=optparse) - > Trevor L Davis (2018). optparse: Command Line Option Parser. - -* [xfun](https://CRAN.R-project.org/package=xfun) - > Yihui Xie (2018). xfun: Miscellaneous Functions by 'Yihui Xie'. - -## Software packaging/containerisation tools - -* [Bioconda](https://www.ncbi.nlm.nih.gov/pubmed/29967506/) - > Grüning B, Dale R, Sjödin A, Chapman BA, Rowe J, Tomkins-Tinch CH, Valieris R, Köster J; Bioconda Team. Bioconda: sustainable and comprehensive software distribution for the life sciences. Nat Methods. 2018 Jul;15(7):475-476. doi: 10.1038/s41592-018-0046-7. PubMed PMID: 29967506. - -* [Anaconda](https://anaconda.com) - > Anaconda Software Distribution. Computer software. Vers. 2-2.4.0. Anaconda, Nov. 2016. Web. - -* [Singularity](https://www.ncbi.nlm.nih.gov/pubmed/28494014/) - > Kurtzer GM, Sochat V, Bauer MW. Singularity: Scientific containers for mobility of compute. PLoS One. 2017 May 11;12(5):e0177459. doi: 10.1371/journal.pone.0177459. eCollection 2017. PubMed PMID: 28494014; PubMed Central PMCID: PMC5426675. - -* [Docker](https://dl.acm.org/doi/10.5555/2600239.2600241) +# nf-core/chipseq: Citations +## [nf-core](https://pubmed.ncbi.nlm.nih.gov/32055031/) + +> Ewels PA, Peltzer A, Fillinger S, Patel H, Alneberg J, Wilm A, Garcia MU, Di Tommaso P, Nahnsen S. The nf-core framework for community-curated bioinformatics pipelines. Nat Biotechnol. 2020 Mar;38(3):276-278. doi: 10.1038/s41587-020-0439-x. PubMed PMID: 32055031. + +## [Nextflow](https://pubmed.ncbi.nlm.nih.gov/28398311/) + +> Di Tommaso P, Chatzou M, Floden EW, Barja PP, Palumbo E, Notredame C. Nextflow enables reproducible computational workflows. Nat Biotechnol. 2017 Apr 11;35(4):316-319. doi: 10.1038/nbt.3820. PubMed PMID: 28398311. +## Pipeline tools + +* [BWA](https://www.ncbi.nlm.nih.gov/pubmed/19451168/) + > Li H, Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 2009 Jul 15;25(14):1754-60. doi: 10.1093/bioinformatics/btp324. Epub 2009 May 18. PubMed PMID: 19451168; PubMed Central PMCID: PMC2705234. + +* [BEDTools](https://www.ncbi.nlm.nih.gov/pubmed/20110278/) + > Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010 Mar 15;26(6):841-2. doi: 10.1093/bioinformatics/btq033. Epub 2010 Jan 28. PubMed PMID: 20110278; PubMed Central PMCID: PMC2832824. + +* [SAMtools](https://www.ncbi.nlm.nih.gov/pubmed/19505943/) + > Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R; 1000 Genome Project Data Processing Subgroup. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 2009 Aug 15;25(16):2078-9. doi: 10.1093/bioinformatics/btp352. Epub 2009 Jun 8. PubMed PMID: 19505943; PubMed Central PMCID: PMC2723002. + +* [BamTools](https://www.ncbi.nlm.nih.gov/pubmed/21493652/) + > Barnett DW, Garrison EK, Quinlan AR, Strömberg MP, Marth GT. BamTools: a C++ API and toolkit for analyzing and managing BAM files. Bioinformatics. 2011 Jun 15;27(12):1691-2. doi: 10.1093/bioinformatics/btr174. Epub 2011 Apr 14. PubMed PMID: 21493652; PubMed Central PMCID: PMC3106182. + +* [UCSC tools](https://www.ncbi.nlm.nih.gov/pubmed/20639541/) + > Kent WJ, Zweig AS, Barber G, Hinrichs AS, Karolchik D. BigWig and BigBed: enabling browsing of large distributed datasets. Bioinformatics. 2010 Sep 1;26(17):2204-7. doi: 10.1093/bioinformatics/btq351. Epub 2010 Jul 17. PubMed PMID: 20639541; PubMed Central PMCID: PMC2922891. + +* [preseq](https://www.ncbi.nlm.nih.gov/pubmed/23435259/) + > Daley T, Smith AD. Predicting the molecular complexity of sequencing libraries. Nat Methods. 2013 Apr;10(4):325-7. doi: 10.1038/nmeth.2375. Epub 2013 Feb 24. PubMed PMID: 23435259; PubMed Central PMCID: PMC3612374. + +* [deepTools](https://www.ncbi.nlm.nih.gov/pubmed/27079975/) + > Ramírez F, Ryan DP, Grüning B, Bhardwaj V, Kilpert F, Richter AS, Heyne S, Dündar F, Manke T. deepTools2: a next generation web server for deep-sequencing data analysis. Nucleic Acids Res. 2016 Jul 8;44(W1):W160-5. doi: 10.1093/nar/gkw257. Epub 2016 Apr 13. PubMed PMID: 27079975; PubMed Central PMCID: PMC4987876. + +* [MACS2](https://www.ncbi.nlm.nih.gov/pubmed/18798982/) + > Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W, Liu XS. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008;9(9):R137. doi: 10.1186/gb-2008-9-9-r137. Epub 2008 Sep 17. PubMed PMID: 18798982; PubMed Central PMCID: PMC2592715. + +* [HOMER](https://www.ncbi.nlm.nih.gov/pubmed/20513432/) + > Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010 May 28;38(4):576-89. doi: 10.1016/j.molcel.2010.05.004. PubMed PMID: 20513432; PubMed Central PMCID: PMC2898526. + +* [phantompeakqualtools](https://www.ncbi.nlm.nih.gov/pubmed/22955991/) + > Landt SG, Marinov GK, Kundaje A, Kheradpour P, Pauli F, Batzoglou S, Bernstein BE, Bickel P, Brown JB, Cayting P, Chen Y, DeSalvo G, Epstein C, Fisher-Aylor KI, Euskirchen G, Gerstein M, Gertz J, Hartemink AJ, Hoffman MM, Iyer VR, Jung YL, Karmakar S, Kellis M, Kharchenko PV, Li Q, Liu T, Liu XS, Ma L, Milosavljevic A, Myers RM, Park PJ, Pazin MJ, Perry MD, Raha D, Reddy TE, Rozowsky J, Shoresh N, Sidow A, Slattery M, Stamatoyannopoulos JA, Tolstorukov MY, White KP, Xi S, Farnham PJ, Lieb JD, Wold BJ, Snyder M. ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res. 2012 Sep;22(9):1813-31. doi: 10.1101/gr.136184.111. PubMed PMID: 22955991; PubMed Central PMCID: PMC3431496. + +* [featureCounts](https://www.ncbi.nlm.nih.gov/pubmed/24227677/) + > Liao Y, Smyth GK, Shi W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014 Apr 1;30(7):923-30. doi: 10.1093/bioinformatics/btt656. Epub 2013 Nov 13. PubMed PMID: 24227677. + +* [MultiQC](https://pubmed.ncbi.nlm.nih.gov/27312411/) + > Ewels P, Magnusson M, Lundin S, Käller M. MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics. 2016 Oct 1;32(19):3047-8. doi: 10.1093/bioinformatics/btw354. Epub 2016 Jun 16. PubMed PMID: 27312411; PubMed Central PMCID: PMC5039924. + +* [FastQC](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/) + +* [Trim Galore!](https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/) + +* [picard-tools](http://broadinstitute.github.io/picard) + +* [pysam](https://github.com/pysam-developers/pysam) + +## R packages + +* [R](https://www.R-project.org/) + > R Core Team (2017). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. + +* [DESeq2](https://www.ncbi.nlm.nih.gov/pubmed/25516281/) + > Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550. PubMed PMID: 25516281; PubMed Central PMCID: PMC4302049. + +* [vsn](https://bioconductor.org/packages/release/bioc/html/vsn.html) + > Wolfgang Huber, Anja von Heydebreck, Holger Sueltmann, Annemarie Poustka and Martin Vingron. Variance Stabilization Applied to Microarray Data Calibration and to the Quantification of Differential Expression. Bioinformatics 18, S96-S104 (2002). + +* [UpSetR](https://CRAN.R-project.org/package=UpSetR) + > Nils Gehlenborg (2017). UpSetR: A More Scalable Alternative to Venn and Euler Diagrams for Visualizing Intersecting Sets. + +* [ggplot2](https://cran.r-project.org/web/packages/ggplot2/index.html) + > H. Wickham. ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag New York, 2016. + +* [reshape2](http://www.jstatsoft.org/v21/i12/) + > Hadley Wickham (2007). Reshaping Data with the reshape Package. Journal of Statistical Software, 21(12), 1-20. + +* [scales](https://CRAN.R-project.org/package=scales) + > Hadley Wickham (2018). scales: Scale Functions for Visualization. + +* [pheatmap](https://CRAN.R-project.org/package=pheatmap) + > Raivo Kolde (2018). pheatmap: Pretty Heatmaps. + +* [lattice](https://cran.r-project.org/web/packages/lattice/index.html) + > Sarkar, Deepayan (2008) Lattice: Multivariate Data Visualization with R. Springer, New York. ISBN 978-0-387-75968-5. + +* [RColorBrewer](https://CRAN.R-project.org/package=RColorBrewer) + > Erich Neuwirth (2014). RColorBrewer: ColorBrewer Palettes. + +* [optparse](https://CRAN.R-project.org/package=optparse) + > Trevor L Davis (2018). optparse: Command Line Option Parser. + +* [xfun](https://CRAN.R-project.org/package=xfun) + > Yihui Xie (2018). xfun: Miscellaneous Functions by 'Yihui Xie'. + +## Software packaging/containerisation tools + +* [Anaconda](https://anaconda.com) + > Anaconda Software Distribution. Computer software. Vers. 2-2.4.0. Anaconda, Nov. 2016. Web. + +* [Bioconda](https://pubmed.ncbi.nlm.nih.gov/29967506/) + > Grüning B, Dale R, Sjödin A, Chapman BA, Rowe J, Tomkins-Tinch CH, Valieris R, Köster J; Bioconda Team. Bioconda: sustainable and comprehensive software distribution for the life sciences. Nat Methods. 2018 Jul;15(7):475-476. doi: 10.1038/s41592-018-0046-7. PubMed PMID: 29967506. + +* [BioContainers](https://pubmed.ncbi.nlm.nih.gov/28379341/) + > da Veiga Leprevost F, Grüning B, Aflitos SA, Röst HL, Uszkoreit J, Barsnes H, Vaudel M, Moreno P, Gatto L, Weber J, Bai M, Jimenez RC, Sachsenberg T, Pfeuffer J, Alvarez RV, Griss J, Nesvizhskii AI, Perez-Riverol Y. BioContainers: an open-source and community-driven framework for software standardization. Bioinformatics. 2017 Aug 15;33(16):2580-2582. doi: 10.1093/bioinformatics/btx192. PubMed PMID: 28379341; PubMed Central PMCID: PMC5870671. + +* [Docker](https://dl.acm.org/doi/10.5555/2600239.2600241) + +* [Singularity](https://pubmed.ncbi.nlm.nih.gov/28494014/) + > Kurtzer GM, Sochat V, Bauer MW. Singularity: Scientific containers for mobility of compute. PLoS One. 2017 May 11;12(5):e0177459. doi: 10.1371/journal.pone.0177459. eCollection 2017. PubMed PMID: 28494014; PubMed Central PMCID: PMC5426675. diff --git a/CODE_OF_CONDUCT.md b/CODE_OF_CONDUCT.md index 405fb1bfd..f4fd052f1 100755 --- a/CODE_OF_CONDUCT.md +++ b/CODE_OF_CONDUCT.md @@ -1,46 +1,111 @@ -# Contributor Covenant Code of Conduct +# Code of Conduct at nf-core (v1.0) ## Our Pledge -In the interest of fostering an open and welcoming environment, we as contributors and maintainers pledge to making participation in our project and our community a harassment-free experience for everyone, regardless of age, body size, disability, ethnicity, gender identity and expression, level of experience, nationality, personal appearance, race, religion, or sexual identity and orientation. +In the interest of fostering an open, collaborative, and welcoming environment, we as contributors and maintainers of nf-core, pledge to making participation in our projects and community a harassment-free experience for everyone, regardless of: -## Our Standards +- Age +- Body size +- Familial status +- Gender identity and expression +- Geographical location +- Level of experience +- Nationality and national origins +- Native language +- Physical and neurological ability +- Race or ethnicity +- Religion +- Sexual identity and orientation +- Socioeconomic status -Examples of behavior that contributes to creating a positive environment include: +Please note that the list above is alphabetised and is therefore not ranked in any order of preference or importance. -* Using welcoming and inclusive language -* Being respectful of differing viewpoints and experiences -* Gracefully accepting constructive criticism -* Focusing on what is best for the community -* Showing empathy towards other community members +## Preamble -Examples of unacceptable behavior by participants include: +> Note: This Code of Conduct (CoC) has been drafted by the nf-core Safety Officer and been edited after input from members of the nf-core team and others. "We", in this document, refers to the Safety Officer and members of the nf-core core team, both of whom are deemed to be members of the nf-core community and are therefore required to abide by this Code of Conduct. This document will amended periodically to keep it up-to-date, and in case of any dispute, the most current version will apply. -* The use of sexualized language or imagery and unwelcome sexual attention or advances -* Trolling, insulting/derogatory comments, and personal or political attacks -* Public or private harassment -* Publishing others' private information, such as a physical or electronic address, without explicit permission -* Other conduct which could reasonably be considered inappropriate in a professional setting +An up-to-date list of members of the nf-core core team can be found [here](https://nf-co.re/about). Our current safety officer is Renuka Kudva. + +nf-core is a young and growing community that welcomes contributions from anyone with a shared vision for [Open Science Policies](https://www.fosteropenscience.eu/taxonomy/term/8). Open science policies encompass inclusive behaviours and we strive to build and maintain a safe and inclusive environment for all individuals. + +We have therefore adopted this code of conduct (CoC), which we require all members of our community and attendees in nf-core events to adhere to in all our workspaces at all times. Workspaces include but are not limited to Slack, meetings on Zoom, Jitsi, YouTube live etc. + +Our CoC will be strictly enforced and the nf-core team reserve the right to exclude participants who do not comply with our guidelines from our workspaces and future nf-core activities. + +We ask all members of our community to help maintain a supportive and productive workspace and to avoid behaviours that can make individuals feel unsafe or unwelcome. Please help us maintain and uphold this CoC. + +Questions, concerns or ideas on what we can include? Contact safety [at] nf-co [dot] re ## Our Responsibilities -Project maintainers are responsible for clarifying the standards of acceptable behavior and are expected to take appropriate and fair corrective action in response to any instances of unacceptable behavior. +The safety officer is responsible for clarifying the standards of acceptable behavior and are expected to take appropriate and fair corrective action in response to any instances of unacceptable behaviour. + +The safety officer in consultation with the nf-core core team have the right and responsibility to remove, edit, or reject comments, commits, code, wiki edits, issues, and other contributions that are not aligned to this Code of Conduct, or to ban temporarily or permanently any contributor for other behaviors that they deem inappropriate, threatening, offensive, or harmful. + +Members of the core team or the safety officer who violate the CoC will be required to recuse themselves pending investigation. They will not have access to any reports of the violations and be subject to the same actions as others in violation of the CoC. + +## When are where does this Code of Conduct apply? + +Participation in the nf-core community is contingent on following these guidelines in all our workspaces and events. This includes but is not limited to the following listed alphabetically and therefore in no order of preference: + +- Communicating with an official project email address. +- Communicating with community members within the nf-core Slack channel. +- Participating in hackathons organised by nf-core (both online and in-person events). +- Participating in collaborative work on GitHub, Google Suite, community calls, mentorship meetings, email correspondence. +- Participating in workshops, training, and seminar series organised by nf-core (both online and in-person events). This applies to events hosted on web-based platforms such as Zoom, Jitsi, YouTube live etc. +- Representing nf-core on social media. This includes both official and personal accounts. + +## nf-core cares 😊 + +nf-core's CoC and expectations of respectful behaviours for all participants (including organisers and the nf-core team) include but are not limited to the following (listed in alphabetical order): + +- Ask for consent before sharing another community member’s personal information (including photographs) on social media. +- Be respectful of differing viewpoints and experiences. We are all here to learn from one another and a difference in opinion can present a good learning opportunity. +- Celebrate your accomplishments at events! (Get creative with your use of emojis 🎉 🥳 💯 🙌 !) +- Demonstrate empathy towards other community members. (We don’t all have the same amount of time to dedicate to nf-core. If tasks are pending, don’t hesitate to gently remind members of your team. If you are leading a task, ask for help if you feel overwhelmed.) +- Engage with and enquire after others. (This is especially important given the geographically remote nature of the nf-core community, so let’s do this the best we can) +- Focus on what is best for the team and the community. (When in doubt, ask) +- Graciously accept constructive criticism, yet be unafraid to question, deliberate, and learn. +- Introduce yourself to members of the community. (We’ve all been outsiders and we know that talking to strangers can be hard for some, but remember we’re interested in getting to know you and your visions for open science!) +- Show appreciation and **provide clear feedback**. (This is especially important because we don’t see each other in person and it can be harder to interpret subtleties. Also remember that not everyone understands a certain language to the same extent as you do, so **be clear in your communications to be kind.**) +- Take breaks when you feel like you need them. +- Using welcoming and inclusive language. (Participants are encouraged to display their chosen pronouns on Zoom or in communication on Slack.) + +## nf-core frowns on 😕 + +The following behaviours from any participants within the nf-core community (including the organisers) will be considered unacceptable under this code of conduct. Engaging or advocating for any of the following could result in expulsion from nf-core workspaces. + +- Deliberate intimidation, stalking or following and sustained disruption of communication among participants of the community. This includes hijacking shared screens through actions such as using the annotate tool in conferencing software such as Zoom. +- “Doxing” i.e. posting (or threatening to post) another person’s personal identifying information online. +- Spamming or trolling of individuals on social media. +- Use of sexual or discriminatory imagery, comments, or jokes and unwelcome sexual attention. +- Verbal and text comments that reinforce social structures of domination related to gender, gender identity and expression, sexual orientation, ability, physical appearance, body size, race, age, religion or work experience. + +### Online Trolling + +The majority of nf-core interactions and events are held online. Unfortunately, holding events online comes with the added issue of online trolling. This is unacceptable, reports of such behaviour will be taken very seriously, and perpetrators will be excluded from activities immediately. + +All community members are required to ask members of the group they are working within for explicit consent prior to taking screenshots of individuals during video calls. + +## Procedures for Reporting CoC violations -Project maintainers have the right and responsibility to remove, edit, or reject comments, commits, code, wiki edits, issues, and other contributions that are not aligned to this Code of Conduct, or to ban temporarily or permanently any contributor for other behaviors that they deem inappropriate, threatening, offensive, or harmful. +If someone makes you feel uncomfortable through their behaviours or actions, report it as soon as possible. -## Scope +You can reach out to members of the [nf-core core team](https://nf-co.re/about) and they will forward your concerns to the safety officer(s). -This Code of Conduct applies both within project spaces and in public spaces when an individual is representing the project or its community. Examples of representing a project or community include using an official project e-mail address, posting via an official social media account, or acting as an appointed representative at an online or offline event. Representation of a project may be further defined and clarified by project maintainers. +Issues directly concerning members of the core team will be dealt with by other members of the core team and the safety manager, and possible conflicts of interest will be taken into account. nf-core is also in discussions about having an ombudsperson, and details will be shared in due course. -## Enforcement +All reports will be handled with utmost discretion and confidentially. -Instances of abusive, harassing, or otherwise unacceptable behavior may be reported by contacting the project team on [Slack](https://nf-co.re/join/slack). The project team will review and investigate all complaints, and will respond in a way that it deems appropriate to the circumstances. The project team is obligated to maintain confidentiality with regard to the reporter of an incident. Further details of specific enforcement policies may be posted separately. +## Attribution and Acknowledgements -Project maintainers who do not follow or enforce the Code of Conduct in good faith may face temporary or permanent repercussions as determined by other members of the project's leadership. +- The [Contributor Covenant, version 1.4](http://contributor-covenant.org/version/1/4) +- The [OpenCon 2017 Code of Conduct](http://www.opencon2017.org/code_of_conduct) (CC BY 4.0 OpenCon organisers, SPARC and Right to Research Coalition) +- The [eLife innovation sprint 2020 Code of Conduct](https://sprint.elifesciences.org/code-of-conduct/) +- The [Mozilla Community Participation Guidelines v3.1](https://www.mozilla.org/en-US/about/governance/policies/participation/) (version 3.1, CC BY-SA 3.0 Mozilla) -## Attribution +## Changelog -This Code of Conduct is adapted from the [Contributor Covenant][homepage], version 1.4, available at [https://www.contributor-covenant.org/version/1/4/code-of-conduct/][version] +### v1.0 - March 12th, 2021 -[homepage]: https://contributor-covenant.org -[version]: https://www.contributor-covenant.org/version/1/4/code-of-conduct/ +- Complete rewrite from original [Contributor Covenant](http://contributor-covenant.org/) CoC. diff --git a/Dockerfile b/Dockerfile deleted file mode 100644 index 0c5ae5e88..000000000 --- a/Dockerfile +++ /dev/null @@ -1,17 +0,0 @@ -FROM nfcore/base:1.12.1 -LABEL authors="Philip Ewels" \ - description="Docker image containing all software requirements for the nf-core/chipseq pipeline" - -# Install the conda environment -COPY environment.yml / -RUN conda env create --quiet -f /environment.yml && conda clean -a - -# Add conda installation dir to PATH (instead of doing 'conda activate') -ENV PATH /opt/conda/envs/nf-core-chipseq-1.3.0dev/bin:$PATH - -# Dump the details of the installed packages to a file for posterity -RUN conda env export --name nf-core-chipseq-1.3.0dev > nf-core-chipseq-1.3.0dev.yml - -# Instruct R processes to use these empty files instead of clashing with a local version -RUN touch .Rprofile -RUN touch .Renviron diff --git a/README.md b/README.md index b8c3918c1..61512b138 100644 --- a/README.md +++ b/README.md @@ -1,19 +1,34 @@ # ![nf-core/chipseq](docs/images/nf-core-chipseq_logo.png) -[![GitHub Actions CI Status](https://github.com/nf-core/chipseq/workflows/nf-core%20CI/badge.svg)](https://github.com/nf-core/chipseq/actions) -[![GitHub Actions Linting Status](https://github.com/nf-core/chipseq/workflows/nf-core%20linting/badge.svg)](https://github.com/nf-core/chipseq/actions) -[![Nextflow](https://img.shields.io/badge/nextflow-%E2%89%A520.07.1-brightgreen.svg)](https://www.nextflow.io/) -[![DOI](https://zenodo.org/badge/DOI/10.5281/zenodo.3240506.svg)](https://doi.org/10.5281/zenodo.3240506) +[![GitHub Actions CI Status](https://github.com/nf-core/chipseq/workflows/nf-core%20CI/badge.svg)](https://github.com/nf-core/chipseq/actions?query=workflow%3A%22nf-core+CI%22) +[![GitHub Actions Linting Status](https://github.com/nf-core/chipseq/workflows/nf-core%20linting/badge.svg)](https://github.com/nf-core/chipseq/actions?query=workflow%3A%22nf-core+linting%22) +[![AWS CI](https://img.shields.io/badge/CI%20tests-full%20size-FF9900?labelColor=000000&logo=Amazon%20AWS)](https://nf-co.re/chipseq/results) +[![Cite with Zenodo](http://img.shields.io/badge/DOI-10.5281/zenodo.XXXXXXX-1073c8?labelColor=000000)](https://doi.org/10.5281/zenodo.XXXXXXX) -[![install with bioconda](https://img.shields.io/badge/install%20with-bioconda-brightgreen.svg)](https://bioconda.github.io/) -[![Docker](https://img.shields.io/docker/automated/nfcore/chipseq.svg)](https://hub.docker.com/r/nfcore/chipseq) -[![Get help on Slack](http://img.shields.io/badge/slack-nf--core%20%23chipseq-4A154B?logo=slack)](https://nfcore.slack.com/channels/chipseq) +[![Nextflow](https://img.shields.io/badge/nextflow%20DSL2-%E2%89%A521.04.0-23aa62.svg?labelColor=000000)](https://www.nextflow.io/) +[![run with conda](http://img.shields.io/badge/run%20with-conda-3EB049?labelColor=000000&logo=anaconda)](https://docs.conda.io/en/latest/) +[![run with docker](https://img.shields.io/badge/run%20with-docker-0db7ed?labelColor=000000&logo=docker)](https://www.docker.com/) +[![run with singularity](https://img.shields.io/badge/run%20with-singularity-1d355c.svg?labelColor=000000)](https://sylabs.io/docs/) + +[![Get help on Slack](http://img.shields.io/badge/slack-nf--core%20%23chipseq-4A154B?labelColor=000000&logo=slack)](https://nfcore.slack.com/channels/chipseq) +[![Follow on Twitter](http://img.shields.io/badge/twitter-%40nf__core-1DA1F2?labelColor=000000&logo=twitter)](https://twitter.com/nf_core) +[![Watch on YouTube](http://img.shields.io/badge/youtube-nf--core-FF0000?labelColor=000000&logo=youtube)](https://www.youtube.com/c/nf-core) ## Introduction **nfcore/chipseq** is a bioinformatics analysis pipeline used for Chromatin ImmunopreciPitation sequencing (ChIP-seq) data. -The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool to run tasks across multiple compute infrastructures in a very portable manner. It comes with docker containers making installation trivial and results highly reproducible. +The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool to run tasks across multiple compute infrastructures in a very portable manner. It uses Docker/Singularity containers making installation trivial and results highly reproducible. The [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) implementation of this pipeline uses one container per process which makes it much easier to maintain and update software dependencies. Where possible, these processes have been submitted to and installed from [nf-core/modules](https://github.com/nf-core/modules) in order to make them available to all nf-core pipelines, and to everyone within the Nextflow community! + + +On release, automated continuous integration tests run the pipeline on a full-sized dataset on the AWS cloud infrastructure. This ensures that the pipeline runs on AWS, has sensible resource allocation defaults set to run on real-world datasets, and permits the persistent storage of results to benchmark between pipeline releases and other analysis sources. The results obtained from the full-sized test can be viewed on the [nf-core website](https://nf-co.re/chipseq/results). + +## Pipeline summary + + + +1. Read QC ([`FastQC`](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/)) +2. Present QC for raw reads ([`MultiQC`](http://multiqc.info/)) ## Pipeline summary @@ -49,17 +64,19 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool ## Quick Start -1. Install [`nextflow`](https://nf-co.re/usage/installation) +1. Install [`Nextflow`](https://www.nextflow.io/docs/latest/getstarted.html#installation) (`>=21.04.0`) -2. Install any of [`Docker`](https://docs.docker.com/engine/installation/), [`Singularity`](https://www.sylabs.io/guides/3.0/user-guide/) or [`Podman`](https://podman.io/) for full pipeline reproducibility _(please only use [`Conda`](https://conda.io/miniconda.html) as a last resort; see [docs](https://nf-co.re/usage/configuration#basic-configuration-profiles))_ +2. Install any of [`Docker`](https://docs.docker.com/engine/installation/), [`Singularity`](https://www.sylabs.io/guides/3.0/user-guide/), [`Podman`](https://podman.io/), [`Shifter`](https://nersc.gitlab.io/development/shifter/how-to-use/) or [`Charliecloud`](https://hpc.github.io/charliecloud/) for full pipeline reproducibility _(please only use [`Conda`](https://conda.io/miniconda.html) as a last resort; see [docs](https://nf-co.re/usage/configuration#basic-configuration-profiles))_ 3. Download the pipeline and test it on a minimal dataset with a single command: - ```bash - nextflow run nf-core/chipseq -profile test, + ```console + nextflow run nf-core/chipseq -profile test, ``` - > Please check [nf-core/configs](https://github.com/nf-core/configs#documentation) to see if a custom config file to run nf-core pipelines already exists for your Institute. If so, you can simply use `-profile ` in your command. This will enable either `docker` or `singularity` and set the appropriate execution settings for your local compute environment. + > * Please check [nf-core/configs](https://github.com/nf-core/configs#documentation) to see if a custom config file to run nf-core pipelines already exists for your Institute. If so, you can simply use `-profile ` in your command. This will enable either `docker` or `singularity` and set the appropriate execution settings for your local compute environment. + > * If you are using `singularity` then the pipeline will auto-detect this and attempt to download the Singularity images directly as opposed to performing a conversion from Docker images. If you are persistently observing issues downloading Singularity images directly due to timeout or network issues then please use the `--singularity_pull_docker_container` parameter to pull and convert the Docker image instead. Alternatively, it is highly recommended to use the [`nf-core download`](https://nf-co.re/tools/#downloading-pipelines-for-offline-use) command to pre-download all of the required containers before running the pipeline and to set the [`NXF_SINGULARITY_CACHEDIR` or `singularity.cacheDir`](https://www.nextflow.io/docs/latest/singularity.html?#singularity-docker-hub) Nextflow options to be able to store and re-use the images from a central location for future pipeline runs. + > * If you are using `conda`, it is highly recommended to use the [`NXF_CONDA_CACHEDIR` or `conda.cacheDir`](https://www.nextflow.io/docs/latest/conda.html) settings to store the environments in a central location for future pipeline runs. 4. Start running your own analysis! @@ -89,6 +106,9 @@ For further information or help, don't hesitate to get in touch on the [Slack `# If you use nf-core/chipseq for your analysis, please cite it using the following doi: [10.5281/zenodo.3240506](https://doi.org/10.5281/zenodo.3240506) + +An extensive list of references for the tools used by the pipeline can be found in the [`CITATIONS.md`](CITATIONS.md) file. + You can cite the `nf-core` publication as follows: An extensive list of references for the tools used by the pipeline can be found in the [`CITATIONS.md`](CITATIONS.md) file. diff --git a/assets/email_template.html b/assets/email_template.html index a3f19225f..5a4548bb0 100644 --- a/assets/email_template.html +++ b/assets/email_template.html @@ -1,6 +1,5 @@ - diff --git a/assets/samplesheet.csv b/assets/samplesheet.csv new file mode 100644 index 000000000..5f653ab7b --- /dev/null +++ b/assets/samplesheet.csv @@ -0,0 +1,3 @@ +sample,fastq_1,fastq_2 +SAMPLE_PAIRED_END,/path/to/fastq/files/AEG588A1_S1_L002_R1_001.fastq.gz,/path/to/fastq/files/AEG588A1_S1_L002_R2_001.fastq.gz +SAMPLE_SINGLE_END,/path/to/fastq/files/AEG588A4_S4_L003_R1_001.fastq.gz, diff --git a/assets/schema_input.json b/assets/schema_input.json new file mode 100644 index 000000000..a024fd708 --- /dev/null +++ b/assets/schema_input.json @@ -0,0 +1,39 @@ +{ + "$schema": "http://json-schema.org/draft-07/schema", + "$id": "https://raw.githubusercontent.com/nf-core/chipseq/master/assets/schema_input.json", + "title": "nf-core/chipseq pipeline - params.input schema", + "description": "Schema for the file provided with params.input", + "type": "array", + "items": { + "type": "object", + "properties": { + "sample": { + "type": "string", + "pattern": "^\\S+$", + "errorMessage": "Sample name must be provided and cannot contain spaces" + }, + "fastq_1": { + "type": "string", + "pattern": "^\\S+\\.f(ast)?q\\.gz$", + "errorMessage": "FastQ file for reads 1 must be provided, cannot contain spaces and must have extension '.fq.gz' or '.fastq.gz'" + }, + "fastq_2": { + "errorMessage": "FastQ file for reads 2 cannot contain spaces and must have extension '.fq.gz' or '.fastq.gz'", + "anyOf": [ + { + "type": "string", + "pattern": "^\\S+\\.f(ast)?q\\.gz$" + }, + { + "type": "string", + "maxLength": 0 + } + ] + } + }, + "required": [ + "sample", + "fastq_1" + ] + } +} diff --git a/assets/sendmail_template.txt b/assets/sendmail_template.txt index f46cdb701..1da35e63f 100644 --- a/assets/sendmail_template.txt +++ b/assets/sendmail_template.txt @@ -15,15 +15,15 @@ Content-ID: Content-Disposition: inline; filename="nf-core-chipseq_logo.png" <% out << new File("$projectDir/assets/nf-core-chipseq_logo.png"). - bytes. - encodeBase64(). - toString(). - tokenize( '\n' )*. - toList()*. - collate( 76 )*. - collect { it.join() }. - flatten(). - join( '\n' ) %> + bytes. + encodeBase64(). + toString(). + tokenize( '\n' )*. + toList()*. + collate( 76 )*. + collect { it.join() }. + flatten(). + join( '\n' ) %> <% if (mqcFile){ @@ -37,15 +37,15 @@ Content-ID: Content-Disposition: attachment; filename=\"${mqcFileObj.getName()}\" ${mqcFileObj. - bytes. - encodeBase64(). - toString(). - tokenize( '\n' )*. - toList()*. - collate( 76 )*. - collect { it.join() }. - flatten(). - join( '\n' )} + bytes. + encodeBase64(). + toString(). + tokenize( '\n' )*. + toList()*. + collate( 76 )*. + collect { it.join() }. + flatten(). + join( '\n' )} """ }} %> diff --git a/bin/scrape_software_versions.py b/bin/scrape_software_versions.py index e2b87c787..e1519ee13 100755 --- a/bin/scrape_software_versions.py +++ b/bin/scrape_software_versions.py @@ -3,32 +3,34 @@ import os results = {} -version_files = [x for x in os.listdir('.') if x.endswith('.version.txt')] +version_files = [x for x in os.listdir(".") if x.endswith(".version.txt")] for version_file in version_files: - software = version_file.replace('.version.txt','') - if software == 'pipeline': - software = 'nf-core/chipseq' + software = version_file.replace(".version.txt", "") + if software == "pipeline": + software = "nf-core/rnaseq" with open(version_file) as fin: version = fin.read().strip() results[software] = version # Dump to YAML -print (''' +print( + """ id: 'software_versions' -section_name: 'nf-core/chipseq Software Versions' -section_href: 'https://github.com/nf-core/chipseq' +section_name: 'nf-core/rnaseq Software Versions' +section_href: 'https://github.com/nf-core/rnaseq' plot_type: 'html' description: 'are collected at run time from the software output.' data: |
-''') -for k,v in sorted(results.items()): - print("
{}
{}
".format(k,v)) -print ("
") +""" +) +for k, v in sorted(results.items()): + print("
{}
{}
".format(k, v)) +print(" ") -# Write out regexes as csv file: -with open('software_versions.csv', 'w') as f: - for k,v in sorted(results.items()): - f.write("{}\t{}\n".format(k,v)) +# Write out as tsv file: +with open("software_versions.tsv", "w") as f: + for k, v in sorted(results.items()): + f.write("{}\t{}\n".format(k, v)) diff --git a/conf/base.config b/conf/base.config index ea4261cd6..8d45c71a9 100644 --- a/conf/base.config +++ b/conf/base.config @@ -1,48 +1,50 @@ /* - * ------------------------------------------------- - * nf-core/chipseq Nextflow base config file - * ------------------------------------------------- - * A 'blank slate' config file, appropriate for general - * use on most high performace compute environments. - * Assumes that all software is installed and available - * on the PATH. Runs in `local` mode - all jobs will be - * run on the logged in environment. - */ +======================================================================================== + nf-core/chipseq Nextflow base config file +======================================================================================== + A 'blank slate' config file, appropriate for general use on most high performance + compute environments. Assumes that all software is installed and available on + the PATH. Runs in `local` mode - all jobs will be run on the logged in environment. +---------------------------------------------------------------------------------------- +*/ process { - cpus = { check_max( 1 * task.attempt, 'cpus' ) } - memory = { check_max( 6.GB * task.attempt, 'memory' ) } - time = { check_max( 4.h * task.attempt, 'time' ) } + cpus = { check_max( 1 * task.attempt, 'cpus' ) } + memory = { check_max( 6.GB * task.attempt, 'memory' ) } + time = { check_max( 4.h * task.attempt, 'time' ) } - errorStrategy = { task.exitStatus in [143,137,104,134,139] ? 'retry' : 'finish' } - maxRetries = 1 - maxErrors = '-1' - - // Process-specific resource requirements - withLabel:process_low { - cpus = { check_max( 2 * task.attempt, 'cpus' ) } - memory = { check_max( 12.GB * task.attempt, 'memory' ) } - time = { check_max( 6.h * task.attempt, 'time' ) } - } - withLabel:process_medium { - cpus = { check_max( 6 * task.attempt, 'cpus' ) } - memory = { check_max( 36.GB * task.attempt, 'memory' ) } - time = { check_max( 8.h * task.attempt, 'time' ) } - } - withLabel:process_high { - cpus = { check_max( 12 * task.attempt, 'cpus' ) } - memory = { check_max( 72.GB * task.attempt, 'memory' ) } - time = { check_max( 16.h * task.attempt, 'time' ) } - } - withLabel:process_long { - time = { check_max( 20.h * task.attempt, 'time' ) } - } - withLabel:error_ignore { - errorStrategy = 'ignore' - } - //withName:GET_SOFTWARE_VERSIONS { - // cache = false - //} + errorStrategy = { task.exitStatus in [143,137,104,134,139] ? 'retry' : 'finish' } + maxRetries = 1 + maxErrors = '-1' + // Process-specific resource requirements + withLabel:process_low { + cpus = { check_max( 2 * task.attempt, 'cpus' ) } + memory = { check_max( 12.GB * task.attempt, 'memory' ) } + time = { check_max( 4.h * task.attempt, 'time' ) } + } + withLabel:process_medium { + cpus = { check_max( 6 * task.attempt, 'cpus' ) } + memory = { check_max( 36.GB * task.attempt, 'memory' ) } + time = { check_max( 8.h * task.attempt, 'time' ) } + } + withLabel:process_high { + cpus = { check_max( 12 * task.attempt, 'cpus' ) } + memory = { check_max( 72.GB * task.attempt, 'memory' ) } + time = { check_max( 16.h * task.attempt, 'time' ) } + } + withLabel:process_long { + time = { check_max( 20.h * task.attempt, 'time' ) } + } + withLabel:process_high_memory { + memory = { check_max( 200.GB * task.attempt, 'memory' ) } + } + withLabel:error_ignore { + errorStrategy = 'ignore' + } + withLabel:error_retry { + errorStrategy = 'retry' + maxRetries = 2 + } } diff --git a/conf/igenomes.config b/conf/igenomes.config index 166b64c6d..855948def 100644 --- a/conf/igenomes.config +++ b/conf/igenomes.config @@ -1,421 +1,432 @@ /* - * ------------------------------------------------- - * Nextflow config file for iGenomes paths - * ------------------------------------------------- - * Defines reference genomes, using iGenome paths - * Can be used by any config that customises the base - * path using $params.igenomes_base / --igenomes_base - */ +======================================================================================== + Nextflow config file for iGenomes paths +======================================================================================== + Defines reference genomes using iGenome paths. + Can be used by any config that customises the base path using: + $params.igenomes_base / --igenomes_base +---------------------------------------------------------------------------------------- +*/ params { - // illumina iGenomes reference file paths - genomes { - 'GRCh37' { - fasta = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/README.txt" - mito_name = "MT" - macs_gsize = "2.7e9" - blacklist = "${projectDir}/assets/blacklists/GRCh37-blacklist.bed" + // illumina iGenomes reference file paths + genomes { + 'GRCh37' { + fasta = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/README.txt" + mito_name = "MT" + macs_gsize = "2.7e9" + blacklist = "${projectDir}/assets/blacklists/GRCh37-blacklist.bed" + } + 'GRCh38' { + fasta = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Annotation/Genes/genes.bed" + mito_name = "chrM" + macs_gsize = "2.7e9" + blacklist = "${projectDir}/assets/blacklists/hg38-blacklist.bed" + } + 'GRCm38' { + fasta = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/README.txt" + mito_name = "MT" + macs_gsize = "1.87e9" + blacklist = "${projectDir}/assets/blacklists/GRCm38-blacklist.bed" + } + 'TAIR10' { + fasta = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/README.txt" + mito_name = "Mt" + } + 'EB2' { + fasta = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/README.txt" + } + 'UMD3.1' { + fasta = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/README.txt" + mito_name = "MT" + } + 'WBcel235' { + fasta = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Annotation/Genes/genes.bed" + mito_name = "MtDNA" + macs_gsize = "9e7" + } + 'CanFam3.1' { + fasta = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/README.txt" + mito_name = "MT" + } + 'GRCz10' { + fasta = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Annotation/Genes/genes.bed" + mito_name = "MT" + } + 'BDGP6' { + fasta = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Annotation/Genes/genes.bed" + mito_name = "M" + macs_gsize = "1.2e8" + } + 'EquCab2' { + fasta = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/README.txt" + mito_name = "MT" + } + 'EB1' { + fasta = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/README.txt" + } + 'Galgal4' { + fasta = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Annotation/Genes/genes.bed" + mito_name = "MT" + } + 'Gm01' { + fasta = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/README.txt" + } + 'Mmul_1' { + fasta = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/README.txt" + mito_name = "MT" + } + 'IRGSP-1.0' { + fasta = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Annotation/Genes/genes.bed" + mito_name = "Mt" + } + 'CHIMP2.1.4' { + fasta = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/README.txt" + mito_name = "MT" + } + 'Rnor_5.0' { + fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Annotation/Genes/genes.bed" + mito_name = "MT" + } + 'Rnor_6.0' { + fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Annotation/Genes/genes.bed" + mito_name = "MT" + } + 'R64-1-1' { + fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Annotation/Genes/genes.bed" + mito_name = "MT" + macs_gsize = "1.2e7" + } + 'EF2' { + fasta = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/README.txt" + mito_name = "MT" + macs_gsize = "1.21e7" + } + 'Sbi1' { + fasta = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/README.txt" + } + 'Sscrofa10.2' { + fasta = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/README.txt" + mito_name = "MT" + } + 'AGPv3' { + fasta = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Annotation/Genes/genes.bed" + mito_name = "Mt" + } + 'hg38' { + fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Annotation/Genes/genes.bed" + mito_name = "chrM" + macs_gsize = "2.7e9" + blacklist = "${projectDir}/assets/blacklists/hg38-blacklist.bed" + } + 'hg19' { + fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/README.txt" + mito_name = "chrM" + macs_gsize = "2.7e9" + blacklist = "${projectDir}/assets/blacklists/hg19-blacklist.bed" + } + 'mm10' { + fasta = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/README.txt" + mito_name = "chrM" + macs_gsize = "1.87e9" + blacklist = "${projectDir}/assets/blacklists/mm10-blacklist.bed" + } + 'bosTau8' { + fasta = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Annotation/Genes/genes.bed" + mito_name = "chrM" + } + 'ce10' { + fasta = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/README.txt" + mito_name = "chrM" + macs_gsize = "9e7" + } + 'canFam3' { + fasta = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/README.txt" + mito_name = "chrM" + } + 'danRer10' { + fasta = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.bed" + mito_name = "chrM" + macs_gsize = "1.37e9" + } + 'dm6' { + fasta = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Annotation/Genes/genes.bed" + mito_name = "chrM" + macs_gsize = "1.2e8" + } + 'equCab2' { + fasta = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/README.txt" + mito_name = "chrM" + } + 'galGal4' { + fasta = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/README.txt" + mito_name = "chrM" + } + 'panTro4' { + fasta = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/README.txt" + mito_name = "chrM" + } + 'rn6' { + fasta = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Annotation/Genes/genes.bed" + mito_name = "chrM" + } + 'sacCer3' { + fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BismarkIndex/" + readme = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Annotation/README.txt" + mito_name = "chrM" + macs_gsize = "1.2e7" + } + 'susScr3' { + fasta = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/WholeGenomeFasta/genome.fa" + bwa = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BWAIndex/genome.fa" + bowtie2 = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/Bowtie2Index/" + star = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/STARIndex/" + bismark = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BismarkIndex/" + gtf = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/Genes/genes.gtf" + bed12 = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/Genes/genes.bed" + readme = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/README.txt" + mito_name = "chrM" + } } - 'GRCh38' { - fasta = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Annotation/Genes/genes.bed" - mito_name = "chrM" - macs_gsize = "2.7e9" - blacklist = "${projectDir}/assets/blacklists/hg38-blacklist.bed" - } - 'GRCm38' { - fasta = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/README.txt" - mito_name = "MT" - macs_gsize = "1.87e9" - blacklist = "${projectDir}/assets/blacklists/GRCm38-blacklist.bed" - } - 'TAIR10' { - fasta = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/README.txt" - mito_name = "Mt" - } - 'EB2' { - fasta = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/README.txt" - } - 'UMD3.1' { - fasta = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/README.txt" - mito_name = "MT" - } - 'WBcel235' { - fasta = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Annotation/Genes/genes.bed" - mito_name = "MtDNA" - macs_gsize = "9e7" - } - 'CanFam3.1' { - fasta = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/README.txt" - mito_name = "MT" - } - 'GRCz10' { - fasta = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Annotation/Genes/genes.bed" - mito_name = "MT" - } - 'BDGP6' { - fasta = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Annotation/Genes/genes.bed" - mito_name = "M" - macs_gsize = "1.2e8" - } - 'EquCab2' { - fasta = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/README.txt" - mito_name = "MT" - } - 'EB1' { - fasta = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/README.txt" - } - 'Galgal4' { - fasta = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Annotation/Genes/genes.bed" - mito_name = "MT" - } - 'Gm01' { - fasta = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/README.txt" - } - 'Mmul_1' { - fasta = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/README.txt" - mito_name = "MT" - } - 'IRGSP-1.0' { - fasta = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Annotation/Genes/genes.bed" - mito_name = "Mt" - } - 'CHIMP2.1.4' { - fasta = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/README.txt" - mito_name = "MT" - } - 'Rnor_6.0' { - fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Annotation/Genes/genes.bed" - mito_name = "MT" - } - 'R64-1-1' { - fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Annotation/Genes/genes.bed" - mito_name = "MT" - macs_gsize = "1.2e7" - } - 'EF2' { - fasta = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/README.txt" - mito_name = "MT" - macs_gsize = "1.21e7" - } - 'Sbi1' { - fasta = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/README.txt" - } - 'Sscrofa10.2' { - fasta = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/README.txt" - mito_name = "MT" - } - 'AGPv3' { - fasta = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Annotation/Genes/genes.bed" - mito_name = "Mt" - } - 'hg38' { - fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Annotation/Genes/genes.bed" - mito_name = "chrM" - macs_gsize = "2.7e9" - blacklist = "${projectDir}/assets/blacklists/hg38-blacklist.bed" - } - 'hg19' { - fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/README.txt" - mito_name = "chrM" - macs_gsize = "2.7e9" - blacklist = "${projectDir}/assets/blacklists/hg19-blacklist.bed" - } - 'mm10' { - fasta = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/README.txt" - mito_name = "chrM" - macs_gsize = "1.87e9" - blacklist = "${projectDir}/assets/blacklists/mm10-blacklist.bed" - } - 'bosTau8' { - fasta = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Annotation/Genes/genes.bed" - mito_name = "chrM" - } - 'ce10' { - fasta = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/README.txt" - mito_name = "chrM" - macs_gsize = "9e7" - } - 'canFam3' { - fasta = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/README.txt" - mito_name = "chrM" - } - 'danRer10' { - fasta = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.bed" - mito_name = "chrM" - macs_gsize = "1.37e9" - } - 'dm6' { - fasta = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Annotation/Genes/genes.bed" - mito_name = "chrM" - macs_gsize = "1.2e8" - } - 'equCab2' { - fasta = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/README.txt" - mito_name = "chrM" - } - 'galGal4' { - fasta = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/README.txt" - mito_name = "chrM" - } - 'panTro4' { - fasta = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/README.txt" - mito_name = "chrM" - } - 'rn6' { - fasta = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Annotation/Genes/genes.bed" - mito_name = "chrM" - } - 'sacCer3' { - fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BismarkIndex/" - readme = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Annotation/README.txt" - mito_name = "chrM" - macs_gsize = "1.2e7" - } - 'susScr3' { - fasta = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BWAIndex/genome.fa.{amb,ann,bwt,pac,sa}" - bowtie2 = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/Bowtie2Index/genome.{1.bt2,2.bt2,3.bt2,4.bt2,rev.1.bt2,rev.2.bt2}" - star = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/STARIndex/" - bismark = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BismarkIndex/" - gtf = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/Genes/genes.gtf" - bed12 = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/Genes/genes.bed" - readme = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/README.txt" - mito_name = "chrM" - } - } } diff --git a/conf/modules.config b/conf/modules.config index f7bb77dd5..6eec7e272 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -1,21 +1,24 @@ /* - * -------------------------------------------------- - * Config file for defining DSL2 per module options - * -------------------------------------------------- - * - * Available keys to override module options: - * args = Additional arguments appended to command in module. - * args2 = Second set of arguments appended to command in module (multi-tool modules). - * publish_by_id = Publish results in separate folders by meta.id value. - * publish_dir = Directory to publish results. - * publish_files = Groovy map where key = "file_ext" and value = "directory" to only publish results - * for a particular file extension. The value of "directory" is appended to the standard - * "publish_dir" path as defined above. - * If publish_files == null (unspecified) - All files are published. - * If publish_files == Map [:] (empty map) - No files are published. - * suffix = File name suffix for output files - * - */ +======================================================================================== + Config file for defining DSL2 per module options +======================================================================================== + Available keys to override module options: + args = Additional arguments appended to command in module. + args2 = Second set of arguments appended to command in module (multi-tool modules). + args3 = Third set of arguments appended to command in module (multi-tool modules). + publish_dir = Directory to publish results. + publish_by_meta = Groovy list of keys available in meta map to append as directories to "publish_dir" path + If publish_by_meta = true - Value of ${meta['id']} is appended as a directory to "publish_dir" path + If publish_by_meta = ['id', 'custompath'] - If "id" is in meta map and "custompath" isn't then "${meta['id']}/custompath/" + is appended as a directory to "publish_dir" path + If publish_by_meta = false / null - No directories are appended to "publish_dir" path + publish_files = Groovy map where key = "file_ext" and value = "directory" to publish results for that file extension + The value of "directory" is appended to the standard "publish_dir" path as defined above. + If publish_files = null (unspecified) - All files are published. + If publish_files = false - No files are published. + suffix = File name suffix for output files. +---------------------------------------------------------------------------------------- +*/ params { modules { @@ -158,6 +161,7 @@ params { publish_files = ['csv':''] } 'multiqc' { + args = '' publish_dir = "multiqc" } } diff --git a/conf/test.config b/conf/test.config index e3b4016c2..948346acc 100644 --- a/conf/test.config +++ b/conf/test.config @@ -1,11 +1,14 @@ /* - * ------------------------------------------------- - * Nextflow config file for running tests - * ------------------------------------------------- - * Defines bundled input files and everything required - * to run a fast and simple test. Use as follows: - * nextflow run nf-core/chipseq -profile test, - */ +======================================================================================== + Nextflow config file for running minimal tests +======================================================================================== + Defines input files and everything required to run a fast and simple pipeline test. + + Use as follows: + nextflow run nf-core/chipseq -profile test, + +---------------------------------------------------------------------------------------- +*/ params { config_profile_name = 'Test profile' @@ -14,14 +17,14 @@ params { // Limit resources so that this can run on GitHub Actions max_cpus = 2 max_memory = 6.GB - max_time = 12.h + max_time = 6.h // Input data input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/design.csv' // Genome references fasta = 'https://raw.githubusercontent.com/nf-core/test-datasets/atacseq/reference/genome.fa' - gtf = 'https://raw.githubusercontent.com/nf-core/test-datasets/atacseq/reference/genes.gtf' + gtf = 'https://raw.githubusercontent.com/nf-core/test-datasets/atacseq/reference/genes.gtf' // Not mandatory but permits the pipeline to run through peak-calling steps macs_gsize = 1.2e7 diff --git a/conf/test_full.config b/conf/test_full.config index 5f7262382..ae90a3c6a 100755 --- a/conf/test_full.config +++ b/conf/test_full.config @@ -1,19 +1,22 @@ /* - * ------------------------------------------------- - * Nextflow config file for running full-size tests - * ------------------------------------------------- - * Defines bundled input files and everything required - * to run a full size pipeline test. Use as follows: - * nextflow run nf-core/chipseq -profile test_full, - */ +======================================================================================== + Nextflow config file for running full-size tests +======================================================================================== + Defines input files and everything required to run a full size pipeline test. + + Use as follows: + nextflow run nf-core/chipseq -profile test_full, + +---------------------------------------------------------------------------------------- +*/ params { - config_profile_name = 'Full test profile' - config_profile_description = 'Full test dataset to check pipeline function' + config_profile_name = 'Full test profile' + config_profile_description = 'Full test dataset to check pipeline function' - // Input data - input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/design_full.csv' + // Input data for full size test + input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/design_full.csv' - // Genome references - genome = 'hg19' + // Genome references + genome = 'hg19' } diff --git a/docs/README.md b/docs/README.md index 68b828949..ac8a8b69c 100644 --- a/docs/README.md +++ b/docs/README.md @@ -3,8 +3,8 @@ The nf-core/chipseq documentation is split into the following pages: * [Usage](usage.md) - * An overview of how the pipeline works, how to run it and a description of all of the different command-line flags. + * An overview of how the pipeline works, how to run it and a description of all of the different command-line flags. * [Output](output.md) - * An overview of the different results produced by the pipeline and how to interpret them. + * An overview of the different results produced by the pipeline and how to interpret them. You can find a lot more documentation about installing, configuring and running nf-core pipelines on the website: [https://nf-co.re](https://nf-co.re) diff --git a/docs/images/mqc_fastqc_adapter.png b/docs/images/mqc_fastqc_adapter.png new file mode 100755 index 0000000000000000000000000000000000000000..361d0e47acfb424dea1f326590d1eb2f6dfa26b5 GIT binary patch literal 23458 zcmeFZ2UJtryD!S#x<#o93es(Ww4k)maRbte0-+a?-g^xY-3myTE`8G_KvA54)F1tn})nJ5u%TA4Y;^!^{48eL_}p#q-Umo0M|F1 z74+PQh^X8N|9_jcWbq~ zzn+tZC9B75nKdz=gQ8wo9GJ$P{D~3knlI_`-PRhCw34f1oYDLr^;oEbgxa#A^J%*2 z>FfDE*(~JzKFs$t_oeLz))qDU?s}%Q?7b~3Y;lUi^Oy-2@3g?joA4Wkgb6-2=ih*jub)~7yZ`T=L=Z`B`{1jhkB-iSjea94&Eo9A zxN59pv1p_}RO1>EC^q}Z2)ZI;b7JV_x4lMr=Bker2+EK;8~!;JO7re*@ZkDmoV878S*N^yX(F@U1yqt?Is3nnV>7}#(5pk`V3C) zWhB8;CwWIwsVIjH+`<9=YA(j&3DgQdFOOGU~*`36wNC&QDv8> zr?h2PQgnHkp&t^S)q^K!68h~`$PjZW&-Wns;Zlw$M2sc z1xR!u{m|Kih*|Hht#M@eOMM#8O*={^6b9k5B5^eBsrnhVHD7XZ5BWO&F?q(>Y=QFl z`f>yQ9NCoxZCH-1F{#mz_j{QeyY~4h*VeyYZ#S@Z(Pnb7G=ud!RW)5svqM*&GI_za 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_Documentation of pipeline parameters is generated automatically from the pipeline schema and can no longer be found in markdown files._ - ## Introduction This document describes the output produced by the pipeline. Most of the plots are taken from the MultiQC report, which summarises results at the end of the pipeline. @@ -32,7 +28,7 @@ The initial QC and alignments are performed at the library-level e.g. if the sam -[FastQC](http://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/) gives general quality metrics about your reads. It provides information about the quality score distribution across your reads, the per base sequence content (%A/C/G/T). You get information about adapter contamination and other overrepresented sequences. +[FastQC](http://www.bioinformatics.babraham.ac.uk/projects/fastqc/) gives general quality metrics about your sequenced reads. It provides information about the quality score distribution across your reads, per base sequence content (%A/T/G/C), adapter contamination and overrepresented sequences. For further reading and documentation see the [FastQC help pages](http://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/). ### Adapter trimming diff --git a/docs/usage.md b/docs/usage.md index 7b9c7474d..68caa1da7 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -88,6 +88,50 @@ NAIVE_INPUT,3,BLA203A49_S1_L006_R1_001.fastq.gz,,, Example design files have been provided with the pipeline for [paired-end](../assets/design_pe.csv) and [single-end](../assets/design_se.csv) data. +## Samplesheet input + +You will need to create a samplesheet with information about the samples you would like to analyse before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 3 columns, and a header row as shown in the examples below. + +```console +--input '[path to samplesheet file]' +``` + +### Multiple runs of the same sample + +The `sample` identifiers have to be the same when you have re-sequenced the same sample more than once e.g. to increase sequencing depth. The pipeline will concatenate the raw reads before performing any downstream analysis. Below is an example for the same sample sequenced across 3 lanes: + +```console +sample,fastq_1,fastq_2 +CONTROL_REP1,AEG588A1_S1_L002_R1_001.fastq.gz,AEG588A1_S1_L002_R2_001.fastq.gz +CONTROL_REP1,AEG588A1_S1_L003_R1_001.fastq.gz,AEG588A1_S1_L003_R2_001.fastq.gz +CONTROL_REP1,AEG588A1_S1_L004_R1_001.fastq.gz,AEG588A1_S1_L004_R2_001.fastq.gz +``` + +### Full samplesheet + +The pipeline will auto-detect whether a sample is single- or paired-end using the information provided in the samplesheet. The samplesheet can have as many columns as you desire, however, there is a strict requirement for the first 3 columns to match those defined in the table below. + +A final samplesheet file consisting of both single- and paired-end data may look something like the one below. This is for 6 samples, where `TREATMENT_REP3` has been sequenced twice. + +```console +sample,fastq_1,fastq_2 +CONTROL_REP1,AEG588A1_S1_L002_R1_001.fastq.gz,AEG588A1_S1_L002_R2_001.fastq.gz +CONTROL_REP2,AEG588A2_S2_L002_R1_001.fastq.gz,AEG588A2_S2_L002_R2_001.fastq.gz +CONTROL_REP3,AEG588A3_S3_L002_R1_001.fastq.gz,AEG588A3_S3_L002_R2_001.fastq.gz +TREATMENT_REP1,AEG588A4_S4_L003_R1_001.fastq.gz, +TREATMENT_REP2,AEG588A5_S5_L003_R1_001.fastq.gz, +TREATMENT_REP3,AEG588A6_S6_L003_R1_001.fastq.gz, +TREATMENT_REP3,AEG588A6_S6_L004_R1_001.fastq.gz, +``` + +| Column | Description | +|----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------| +| `sample` | Custom sample name. This entry will be identical for multiple sequencing libraries/runs from the same sample. Spaces in sample names are automatically converted to underscores (`_`). | +| `fastq_1` | Full path to FastQ file for Illumina short reads 1. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | +| `fastq_2` | Full path to FastQ file for Illumina short reads 2. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | + +An [example samplesheet](../assets/samplesheet.csv) has been provided with the pipeline. + ## Running the pipeline The typical command for running the pipeline is as follows: @@ -100,7 +144,7 @@ This will launch the pipeline with the `docker` configuration profile. See below Note that the pipeline will create the following files in your working directory: -```bash +```console work # Directory containing the nextflow working files results # Finished results (configurable, see below) .nextflow_log # Log file from Nextflow @@ -111,13 +155,13 @@ results # Finished results (configurable, see below) When you run the above command, Nextflow automatically pulls the pipeline code from GitHub and stores it as a cached version. When running the pipeline after this, it will always use the cached version if available - even if the pipeline has been updated since. To make sure that you're running the latest version of the pipeline, make sure that you regularly update the cached version of the pipeline: -```bash +```console nextflow pull nf-core/chipseq ``` ### Reproducibility -It's a good idea to specify a pipeline version when running the pipeline on your data. This ensures that a specific version of the pipeline code and software are used when you run your pipeline. If you keep using the same tag, you'll be running the same version of the pipeline, even if there have been changes to the code since. +It is a good idea to specify a pipeline version when running the pipeline on your data. This ensures that a specific version of the pipeline code and software are used when you run your pipeline. If you keep using the same tag, you'll be running the same version of the pipeline, even if there have been changes to the code since. First, go to the [nf-core/chipseq releases page](https://github.com/nf-core/chipseq/releases) and find the latest version number - numeric only (eg. `1.3.1`). Then specify this when running the pipeline with `-r` (one hyphen) - eg. `-r 1.3.1`. @@ -131,7 +175,7 @@ This version number will be logged in reports when you run the pipeline, so that Use this parameter to choose a configuration profile. Profiles can give configuration presets for different compute environments. -Several generic profiles are bundled with the pipeline which instruct the pipeline to use software packaged using different methods (Docker, Singularity, Podman, Conda) - see below. +Several generic profiles are bundled with the pipeline which instruct the pipeline to use software packaged using different methods (Docker, Singularity, Podman, Shifter, Charliecloud, Conda) - see below. When using Biocontainers, most of these software packaging methods pull Docker containers from quay.io e.g [FastQC](https://quay.io/repository/biocontainers/fastqc) except for Singularity which directly downloads Singularity images via https hosted by the [Galaxy project](https://depot.galaxyproject.org/singularity/) and Conda which downloads and installs software locally from [Bioconda](https://bioconda.github.io/). > We highly recommend the use of Docker or Singularity containers for full pipeline reproducibility, however when this is not possible, Conda is also supported. @@ -143,21 +187,20 @@ They are loaded in sequence, so later profiles can overwrite earlier profiles. If `-profile` is not specified, the pipeline will run locally and expect all software to be installed and available on the `PATH`. This is _not_ recommended. * `docker` - * A generic configuration profile to be used with [Docker](https://docker.com/) - * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Docker](https://docker.com/) * `singularity` - * A generic configuration profile to be used with [Singularity](https://sylabs.io/docs/) - * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Singularity](https://sylabs.io/docs/) * `podman` - * A generic configuration profile to be used with [Podman](https://podman.io/) - * Pulls software from Docker Hub: [`nfcore/chipseq`](https://hub.docker.com/r/nfcore/chipseq/) + * A generic configuration profile to be used with [Podman](https://podman.io/) +* `shifter` + * A generic configuration profile to be used with [Shifter](https://nersc.gitlab.io/development/shifter/how-to-use/) +* `charliecloud` + * A generic configuration profile to be used with [Charliecloud](https://hpc.github.io/charliecloud/) * `conda` - * Please only use Conda as a last resort i.e. when it's not possible to run the pipeline with Docker, Singularity or Podman. - * A generic configuration profile to be used with [Conda](https://conda.io/docs/) - * Pulls most software from [Bioconda](https://bioconda.github.io/) + * A generic configuration profile to be used with [Conda](https://conda.io/docs/). Please only use Conda as a last resort i.e. when it's not possible to run the pipeline with Docker, Singularity, Podman, Shifter or Charliecloud. * `test` - * A profile with a complete configuration for automated testing - * Includes links to test data so needs no other parameters + * A profile with a complete configuration for automated testing + * Includes links to test data so needs no other parameters ### `-resume` @@ -169,27 +212,140 @@ You can also supply a run name to resume a specific run: `-resume [run-name]`. U Specify the path to a specific config file (this is a core Nextflow command). See the [nf-core website documentation](https://nf-co.re/usage/configuration) for more information. -#### Custom resource requests +## Custom configuration + +### Resource requests + +Whilst the default requirements set within the pipeline will hopefully work for most people and with most input data, you may find that you want to customise the compute resources that the pipeline requests. Each step in the pipeline has a default set of requirements for number of CPUs, memory and time. For most of the steps in the pipeline, if the job exits with any of the error codes specified [here](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/base.config#L18) it will automatically be resubmitted with higher requests (2 x original, then 3 x original). If it still fails after the third attempt then the pipeline execution is stopped. + +For example, if the nf-core/rnaseq pipeline is failing after multiple re-submissions of the `STAR_ALIGN` process due to an exit code of `137` this would indicate that there is an out of memory issue: + +```console +[62/149eb0] NOTE: Process `RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)` terminated with an error exit status (137) -- Execution is retried (1) +Error executing process > 'RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)' -Each step in the pipeline has a default set of requirements for number of CPUs, memory and time. For most of the steps in the pipeline, if the job exits with an error code of `143` (exceeded requested resources) it will automatically resubmit with higher requests (2 x original, then 3 x original). If it still fails after three times then the pipeline is stopped. +Caused by: + Process `RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)` terminated with an error exit status (137) -Whilst these default requirements will hopefully work for most people with most data, you may find that you want to customise the compute resources that the pipeline requests. You can do this by creating a custom config file. For example, to give the workflow process `star` 32GB of memory, you could use the following config: +Command executed: + STAR \ + --genomeDir star \ + --readFilesIn WT_REP1_trimmed.fq.gz \ + --runThreadN 2 \ + --outFileNamePrefix WT_REP1. \ + + +Command exit status: + 137 + +Command output: + (empty) + +Command error: + .command.sh: line 9: 30 Killed STAR --genomeDir star --readFilesIn WT_REP1_trimmed.fq.gz --runThreadN 2 --outFileNamePrefix WT_REP1. +Work dir: + /home/pipelinetest/work/9d/172ca5881234073e8d76f2a19c88fb + +Tip: you can replicate the issue by changing to the process work dir and entering the command `bash .command.run` +``` + +To bypass this error you would need to find exactly which resources are set by the `STAR_ALIGN` process. The quickest way is to search for `process STAR_ALIGN` in the [nf-core/rnaseq Github repo](https://github.com/nf-core/rnaseq/search?q=process+STAR_ALIGN). We have standardised the structure of Nextflow DSL2 pipelines such that all module files will be present in the `modules/` directory and so based on the search results the file we want is `modules/nf-core/software/star/align/main.nf`. If you click on the link to that file you will notice that there is a `label` directive at the top of the module that is set to [`label process_high`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/modules/nf-core/software/star/align/main.nf#L9). The [Nextflow `label`](https://www.nextflow.io/docs/latest/process.html#label) directive allows us to organise workflow processes in separate groups which can be referenced in a configuration file to select and configure subset of processes having similar computing requirements. The default values for the `process_high` label are set in the pipeline's [`base.config`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/base.config#L33-L37) which in this case is defined as 72GB. Providing you haven't set any other standard nf-core parameters to __cap__ the [maximum resources](https://nf-co.re/usage/configuration#max-resources) used by the pipeline then we can try and bypass the `STAR_ALIGN` process failure by creating a custom config file that sets at least 72GB of memory, in this case increased to 100GB. The custom config below can then be provided to the pipeline via the [`-c`](#-c) parameter as highlighted in previous sections. ```nextflow process { - withName: star { - memory = 32.GB - } + withName: STAR_ALIGN { + memory = 100.GB + } } ``` -See the main [Nextflow documentation](https://www.nextflow.io/docs/latest/config.html) for more information. +> **NB:** We specify just the process name i.e. `STAR_ALIGN` in the config file and not the full task name string that is printed to screen in the error message or on the terminal whilst the pipeline is running i.e. `RNASEQ:ALIGN_STAR:STAR_ALIGN`. You may get a warning suggesting that the process selector isn't recognised but you can ignore that if the process name has been specified correctly. This is something that needs to be fixed upstream in core Nextflow. + +### Tool-specific options -If you are likely to be running `nf-core` pipelines regularly it may be a good idea to request that your custom config file is uploaded to the `nf-core/configs` git repository. Before you do this please can you test that the config file works with your pipeline of choice using the `-c` parameter (see definition above). You can then create a pull request to the `nf-core/configs` repository with the addition of your config file, associated documentation file (see examples in [`nf-core/configs/docs`](https://github.com/nf-core/configs/tree/master/docs)), and amending [`nfcore_custom.config`](https://github.com/nf-core/configs/blob/master/nfcore_custom.config) to include your custom profile. +For the ultimate flexibility, we have implemented and are using Nextflow DSL2 modules in a way where it is possible for both developers and users to change tool-specific command-line arguments (e.g. providing an additional command-line argument to the `STAR_ALIGN` process) as well as publishing options (e.g. saving files produced by the `STAR_ALIGN` process that aren't saved by default by the pipeline). In the majority of instances, as a user you won't have to change the default options set by the pipeline developer(s), however, there may be edge cases where creating a simple custom config file can improve the behaviour of the pipeline if for example it is failing due to a weird error that requires setting a tool-specific parameter to deal with smaller / larger genomes. + +The command-line arguments passed to STAR in the `STAR_ALIGN` module are a combination of: + +* Mandatory arguments or those that need to be evaluated within the scope of the module, as supplied in the [`script`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/modules/nf-core/software/star/align/main.nf#L49-L55) section of the module file. + +* An [`options.args`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/modules/nf-core/software/star/align/main.nf#L56) string of non-mandatory parameters that is set to be empty by default in the module but can be overwritten when including the module in the sub-workflow / workflow context via the `addParams` Nextflow option. + +The nf-core/rnaseq pipeline has a sub-workflow (see [terminology](https://github.com/nf-core/modules#terminology)) specifically to align reads with STAR and to sort, index and generate some basic stats on the resulting BAM files using SAMtools. At the top of this file we import the `STAR_ALIGN` module via the Nextflow [`include`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/subworkflows/nf-core/align_star.nf#L10) keyword and by default the options passed to the module via the `addParams` option are set as an empty Groovy map [here](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/subworkflows/nf-core/align_star.nf#L5); this in turn means `options.args` will be set to empty by default in the module file too. This is an intentional design choice and allows us to implement well-written sub-workflows composed of a chain of tools that by default run with the bare minimum parameter set for any given tool in order to make it much easier to share across pipelines and to provide the flexibility for users and developers to customise any non-mandatory arguments. + +When including the sub-workflow above in the main pipeline workflow we use the same `include` statement, however, we now have the ability to overwrite options for each of the tools in the sub-workflow including the [`align_options`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/workflows/rnaseq.nf#L225) variable that will be used specifically to overwrite the optional arguments passed to the `STAR_ALIGN` module. In this case, the options to be provided to `STAR_ALIGN` have been assigned sensible defaults by the developer(s) in the pipeline's [`modules.config`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/modules.config#L70-L74) and can be accessed and customised in the [workflow context](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/workflows/rnaseq.nf#L201-L204) too before eventually passing them to the sub-workflow as a Groovy map called `star_align_options`. These options will then be propagated from `workflow -> sub-workflow -> module`. + +As mentioned at the beginning of this section it may also be necessary for users to overwrite the options passed to modules to be able to customise specific aspects of the way in which a particular tool is executed by the pipeline. Given that all of the default module options are stored in the pipeline's `modules.config` as a [`params` variable](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/modules.config#L24-L25) it is also possible to overwrite any of these options via a custom config file. + +Say for example we want to append an additional, non-mandatory parameter (i.e. `--outFilterMismatchNmax 16`) to the arguments passed to the `STAR_ALIGN` module. Firstly, we need to copy across the default `args` specified in the [`modules.config`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/modules.config#L71) and create a custom config file that is a composite of the default `args` as well as the additional options you would like to provide. This is very important because Nextflow will overwrite the default value of `args` that you provide via the custom config. + +As you will see in the example below, we have: + +* appended `--outFilterMismatchNmax 16` to the default `args` used by the module. +* changed the default `publish_dir` value to where the files will eventually be published in the main results directory. +* appended `'bam':''` to the default value of `publish_files` so that the BAM files generated by the process will also be saved in the top-level results directory for the module. Note: `'out':'log'` means any file/directory ending in `out` will now be saved in a separate directory called `my_star_directory/log/`. + +```nextflow +params { + modules { + 'star_align' { + args = "--quantMode TranscriptomeSAM --twopassMode Basic --outSAMtype BAM Unsorted --readFilesCommand zcat --runRNGseed 0 --outFilterMultimapNmax 20 --alignSJDBoverhangMin 1 --outSAMattributes NH HI AS NM MD --quantTranscriptomeBan Singleend --outFilterMismatchNmax 16" + publish_dir = "my_star_directory" + publish_files = ['out':'log', 'tab':'log', 'bam':''] + } + } +} +``` + +### Updating containers + +The [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) implementation of this pipeline uses one container per process which makes it much easier to maintain and update software dependencies. If for some reason you need to use a different version of a particular tool with the pipeline then you just need to identify the `process` name and override the Nextflow `container` definition for that process using the `withName` declaration. For example, in the [nf-core/viralrecon](https://nf-co.re/viralrecon) pipeline a tool called [Pangolin](https://github.com/cov-lineages/pangolin) has been used during the COVID-19 pandemic to assign lineages to SARS-CoV-2 genome sequenced samples. Given that the lineage assignments change quite frequently it doesn't make sense to re-release the nf-core/viralrecon everytime a new version of Pangolin has been released. However, you can override the default container used by the pipeline by creating a custom config file and passing it as a command-line argument via `-c custom.config`. + +1. Check the default version used by the pipeline in the module file for [Pangolin](https://github.com/nf-core/viralrecon/blob/a85d5969f9025409e3618d6c280ef15ce417df65/modules/nf-core/software/pangolin/main.nf#L14-L19) +2. Find the latest version of the Biocontainer available on [Quay.io](https://quay.io/repository/biocontainers/pangolin?tag=latest&tab=tags) +3. Create the custom config accordingly: + + * For Docker: + + ```nextflow + process { + withName: PANGOLIN { + container = 'quay.io/biocontainers/pangolin:3.0.5--pyhdfd78af_0' + } + } + ``` + + * For Singularity: + + ```nextflow + process { + withName: PANGOLIN { + container = 'https://depot.galaxyproject.org/singularity/pangolin:3.0.5--pyhdfd78af_0' + } + } + ``` + + * For Conda: + + ```nextflow + process { + withName: PANGOLIN { + conda = 'bioconda::pangolin=3.0.5' + } + } + ``` + +> **NB:** If you wish to periodically update individual tool-specific results (e.g. Pangolin) generated by the pipeline then you must ensure to keep the `work/` directory otherwise the `-resume` ability of the pipeline will be compromised and it will restart from scratch. + +### nf-core/configs + +In most cases, you will only need to create a custom config as a one-off but if you and others within your organisation are likely to be running nf-core pipelines regularly and need to use the same settings regularly it may be a good idea to request that your custom config file is uploaded to the `nf-core/configs` git repository. Before you do this please can you test that the config file works with your pipeline of choice using the `-c` parameter. You can then create a pull request to the `nf-core/configs` repository with the addition of your config file, associated documentation file (see examples in [`nf-core/configs/docs`](https://github.com/nf-core/configs/tree/master/docs)), and amending [`nfcore_custom.config`](https://github.com/nf-core/configs/blob/master/nfcore_custom.config) to include your custom profile. + +See the main [Nextflow documentation](https://www.nextflow.io/docs/latest/config.html) for more information about creating your own configuration files. If you have any questions or issues please send us a message on [Slack](https://nf-co.re/join/slack) on the [`#configs` channel](https://nfcore.slack.com/channels/configs). -### Running in the background +## Running in the background Nextflow handles job submissions and supervises the running jobs. The Nextflow process must run until the pipeline is finished. @@ -198,11 +354,11 @@ The Nextflow `-bg` flag launches Nextflow in the background, detached from your Alternatively, you can use `screen` / `tmux` or similar tool to create a detached session which you can log back into at a later time. Some HPC setups also allow you to run nextflow within a cluster job submitted your job scheduler (from where it submits more jobs). -#### Nextflow memory requirements +## Nextflow memory requirements In some cases, the Nextflow Java virtual machines can start to request a large amount of memory. We recommend adding the following line to your environment to limit this (typically in `~/.bashrc` or `~./bash_profile`): -```bash +```console NXF_OPTS='-Xms1g -Xmx4g' ``` diff --git a/environment.yml b/environment.yml deleted file mode 100644 index 361352d0c..000000000 --- a/environment.yml +++ /dev/null @@ -1,33 +0,0 @@ -# You can use this file to create a conda environment for this pipeline: -# conda env create -f environment.yml -name: nf-core-chipseq-1.3.0dev -channels: - - conda-forge - - bioconda - - defaults -dependencies: - ## conda-forge packages - - conda-forge::python=3.7.8 - - conda-forge::markdown=3.2.2 - - conda-forge::pymdown-extensions=7.1 - - conda-forge::pygments=2.6.1 - - conda-forge::r-base=4.0.2 - - conda-forge::r-optparse=1.6.6 - - conda-forge::r-rcolorbrewer=1.1_2 - - conda-forge::r-reshape2=1.4.4 - - conda-forge::r-ggplot2=3.3.2 - - conda-forge::r-tidyr=1.1.0 - - conda-forge::r-scales=1.1.1 - - conda-forge::r-pheatmap=1.0.12 - - conda-forge::r-lattice=0.20_41 - - conda-forge::r-upsetr=1.4.0 - - conda-forge::r-xfun=0.16 - - ## bioconda packages - - bioconda::samtools=1.10 - - bioconda::bamtools=2.5.1 - - bioconda::pysam=0.16.0.1 - - bioconda::bedtools=2.29.2 - - bioconda::bioconductor-biocparallel=1.22.0 - - bioconda::bioconductor-deseq2=1.28.0 - - bioconda::bioconductor-vsn=3.56.0 diff --git a/lib/Checks.groovy b/lib/Checks.groovy deleted file mode 100755 index 034e9d838..000000000 --- a/lib/Checks.groovy +++ /dev/null @@ -1,47 +0,0 @@ -/* - * This file holds several functions used to perform standard checks for the nf-core pipeline template. - */ - -class Checks { - - static void aws_batch(workflow, params) { - if (workflow.profile.contains('awsbatch')) { - assert !params.awsqueue || !params.awsregion : "Specify correct --awsqueue and --awsregion parameters on AWSBatch!" - // Check outdir paths to be S3 buckets if running on AWSBatch - // related: https://github.com/nextflow-io/nextflow/issues/813 - assert !params.outdir.startsWith('s3:') : "Outdir not on S3 - specify S3 Bucket to run on AWSBatch!" - // Prevent trace files to be stored on S3 since S3 does not support rolling files. - assert params.tracedir.startsWith('s3:') : "Specify a local tracedir or run without trace! S3 cannot be used for tracefiles." - } - } - - static void hostname(workflow, params, log) { - Map colors = Headers.log_colours(params.monochrome_logs) - if (params.hostnames) { - def hostname = "hostname".execute().text.trim() - params.hostnames.each { prof, hnames -> - hnames.each { hname -> - if (hostname.contains(hname) && !workflow.profile.contains(prof)) { - log.info "=${colors.yellow}====================================================${colors.reset}=\n" + - "${colors.yellow}WARN: You are running with `-profile $workflow.profile`\n" + - " but your machine hostname is ${colors.white}'$hostname'${colors.reset}.\n" + - " ${colors.yellow_bold}Please use `-profile $prof${colors.reset}`\n" + - "=${colors.yellow}====================================================${colors.reset}=" - } - } - } - } - } - - // Show a big warning message if we're not running MACS - static void macs2_warn(params, log) { - if (!params.macs_gsize) { - def warnstring = params.genome ? "supported for '${params.genome}'" : 'supplied' - log.warn "=================================================================\n" + - " WARNING! MACS genome size parameter not $warnstring.\n" + - " Peak calling, annotation and differential analysis will be skipped.\n" + - " Please specify value for '--macs_gsize' to run these steps.\n" + - "=======================================================================" - } - } -} diff --git a/lib/NfcoreSchema.groovy b/lib/NfcoreSchema.groovy new file mode 100755 index 000000000..8d6920dd6 --- /dev/null +++ b/lib/NfcoreSchema.groovy @@ -0,0 +1,517 @@ +// +// This file holds several functions used to perform JSON parameter validation, help and summary rendering for the nf-core pipeline template. +// + +import org.everit.json.schema.Schema +import org.everit.json.schema.loader.SchemaLoader +import org.everit.json.schema.ValidationException +import org.json.JSONObject +import org.json.JSONTokener +import org.json.JSONArray +import groovy.json.JsonSlurper +import groovy.json.JsonBuilder + +class NfcoreSchema { + + // + // Resolve Schema path relative to main workflow directory + // + public static String getSchemaPath(workflow, schema_filename='nextflow_schema.json') { + return "${workflow.projectDir}/${schema_filename}" + } + + // + // Function to loop over all parameters defined in schema and check + // whether the given parameters adhere to the specifications + // + /* groovylint-disable-next-line UnusedPrivateMethodParameter */ + public static void validateParameters(workflow, params, log, schema_filename='nextflow_schema.json') { + def has_error = false + //=====================================================================// + // Check for nextflow core params and unexpected params + def json = new File(getSchemaPath(workflow, schema_filename=schema_filename)).text + def Map schemaParams = (Map) new JsonSlurper().parseText(json).get('definitions') + def nf_params = [ + // Options for base `nextflow` command + 'bg', + 'c', + 'C', + 'config', + 'd', + 'D', + 'dockerize', + 'h', + 'log', + 'q', + 'quiet', + 'syslog', + 'v', + 'version', + + // Options for `nextflow run` command + 'ansi', + 'ansi-log', + 'bg', + 'bucket-dir', + 'c', + 'cache', + 'config', + 'dsl2', + 'dump-channels', + 'dump-hashes', + 'E', + 'entry', + 'latest', + 'lib', + 'main-script', + 'N', + 'name', + 'offline', + 'params-file', + 'pi', + 'plugins', + 'poll-interval', + 'pool-size', + 'profile', + 'ps', + 'qs', + 'queue-size', + 'r', + 'resume', + 'revision', + 'stdin', + 'stub', + 'stub-run', + 'test', + 'w', + 'with-charliecloud', + 'with-conda', + 'with-dag', + 'with-docker', + 'with-mpi', + 'with-notification', + 'with-podman', + 'with-report', + 'with-singularity', + 'with-timeline', + 'with-tower', + 'with-trace', + 'with-weblog', + 'without-docker', + 'without-podman', + 'work-dir' + ] + def unexpectedParams = [] + + // Collect expected parameters from the schema + def expectedParams = [] + for (group in schemaParams) { + for (p in group.value['properties']) { + expectedParams.push(p.key) + } + } + + for (specifiedParam in params.keySet()) { + // nextflow params + if (nf_params.contains(specifiedParam)) { + log.error "ERROR: You used a core Nextflow option with two hyphens: '--${specifiedParam}'. Please resubmit with '-${specifiedParam}'" + has_error = true + } + // unexpected params + def params_ignore = params.schema_ignore_params.split(',') + 'schema_ignore_params' + def expectedParamsLowerCase = expectedParams.collect{ it.replace("-", "").toLowerCase() } + def specifiedParamLowerCase = specifiedParam.replace("-", "").toLowerCase() + def isCamelCaseBug = (specifiedParam.contains("-") && !expectedParams.contains(specifiedParam) && expectedParamsLowerCase.contains(specifiedParamLowerCase)) + if (!expectedParams.contains(specifiedParam) && !params_ignore.contains(specifiedParam) && !isCamelCaseBug) { + // Temporarily remove camelCase/camel-case params #1035 + def unexpectedParamsLowerCase = unexpectedParams.collect{ it.replace("-", "").toLowerCase()} + if (!unexpectedParamsLowerCase.contains(specifiedParamLowerCase)){ + unexpectedParams.push(specifiedParam) + } + } + } + + //=====================================================================// + // Validate parameters against the schema + InputStream input_stream = new File(getSchemaPath(workflow, schema_filename=schema_filename)).newInputStream() + JSONObject raw_schema = new JSONObject(new JSONTokener(input_stream)) + + // Remove anything that's in params.schema_ignore_params + raw_schema = removeIgnoredParams(raw_schema, params) + + Schema schema = SchemaLoader.load(raw_schema) + + // Clean the parameters + def cleanedParams = cleanParameters(params) + + // Convert to JSONObject + def jsonParams = new JsonBuilder(cleanedParams) + JSONObject params_json = new JSONObject(jsonParams.toString()) + + // Validate + try { + schema.validate(params_json) + } catch (ValidationException e) { + println '' + log.error 'ERROR: Validation of pipeline parameters failed!' + JSONObject exceptionJSON = e.toJSON() + printExceptions(exceptionJSON, params_json, log) + println '' + has_error = true + } + + // Check for unexpected parameters + if (unexpectedParams.size() > 0) { + Map colors = NfcoreTemplate.logColours(params.monochrome_logs) + println '' + def warn_msg = 'Found unexpected parameters:' + for (unexpectedParam in unexpectedParams) { + warn_msg = warn_msg + "\n* --${unexpectedParam}: ${params[unexpectedParam].toString()}" + } + log.warn warn_msg + log.info "- ${colors.dim}Ignore this warning: params.schema_ignore_params = \"${unexpectedParams.join(',')}\" ${colors.reset}" + println '' + } + + if (has_error) { + System.exit(1) + } + } + + // + // Beautify parameters for --help + // + public static String paramsHelp(workflow, params, command, schema_filename='nextflow_schema.json') { + Map colors = NfcoreTemplate.logColours(params.monochrome_logs) + Integer num_hidden = 0 + String output = '' + output += 'Typical pipeline command:\n\n' + output += " ${colors.cyan}${command}${colors.reset}\n\n" + Map params_map = paramsLoad(getSchemaPath(workflow, schema_filename=schema_filename)) + Integer max_chars = paramsMaxChars(params_map) + 1 + Integer desc_indent = max_chars + 14 + Integer dec_linewidth = 160 - desc_indent + for (group in params_map.keySet()) { + Integer num_params = 0 + String group_output = colors.underlined + colors.bold + group + colors.reset + '\n' + def group_params = params_map.get(group) // This gets the parameters of that particular group + for (param in group_params.keySet()) { + if (group_params.get(param).hidden && !params.show_hidden_params) { + num_hidden += 1 + continue; + } + def type = '[' + group_params.get(param).type + ']' + def description = group_params.get(param).description + def defaultValue = group_params.get(param).default ? " [default: " + group_params.get(param).default.toString() + "]" : '' + def description_default = description + colors.dim + defaultValue + colors.reset + // Wrap long description texts + // Loosely based on https://dzone.com/articles/groovy-plain-text-word-wrap + if (description_default.length() > dec_linewidth){ + List olines = [] + String oline = "" // " " * indent + description_default.split(" ").each() { wrd -> + if ((oline.size() + wrd.size()) <= dec_linewidth) { + oline += wrd + " " + } else { + olines += oline + oline = wrd + " " + } + } + olines += oline + description_default = olines.join("\n" + " " * desc_indent) + } + group_output += " --" + param.padRight(max_chars) + colors.dim + type.padRight(10) + colors.reset + description_default + '\n' + num_params += 1 + } + group_output += '\n' + if (num_params > 0){ + output += group_output + } + } + if (num_hidden > 0){ + output += colors.dim + "!! Hiding $num_hidden params, use --show_hidden_params to show them !!\n" + colors.reset + } + output += NfcoreTemplate.dashedLine(params.monochrome_logs) + return output + } + + // + // Groovy Map summarising parameters/workflow options used by the pipeline + // + public static LinkedHashMap paramsSummaryMap(workflow, params, schema_filename='nextflow_schema.json') { + // Get a selection of core Nextflow workflow options + def Map workflow_summary = [:] + if (workflow.revision) { + workflow_summary['revision'] = workflow.revision + } + workflow_summary['runName'] = workflow.runName + if (workflow.containerEngine) { + workflow_summary['containerEngine'] = workflow.containerEngine + } + if (workflow.container) { + workflow_summary['container'] = workflow.container + } + workflow_summary['launchDir'] = workflow.launchDir + workflow_summary['workDir'] = workflow.workDir + workflow_summary['projectDir'] = workflow.projectDir + workflow_summary['userName'] = workflow.userName + workflow_summary['profile'] = workflow.profile + workflow_summary['configFiles'] = workflow.configFiles.join(', ') + + // Get pipeline parameters defined in JSON Schema + def Map params_summary = [:] + def blacklist = ['hostnames'] + def params_map = paramsLoad(getSchemaPath(workflow, schema_filename=schema_filename)) + for (group in params_map.keySet()) { + def sub_params = new LinkedHashMap() + def group_params = params_map.get(group) // This gets the parameters of that particular group + for (param in group_params.keySet()) { + if (params.containsKey(param) && !blacklist.contains(param)) { + def params_value = params.get(param) + def schema_value = group_params.get(param).default + def param_type = group_params.get(param).type + if (schema_value != null) { + if (param_type == 'string') { + if (schema_value.contains('$projectDir') || schema_value.contains('${projectDir}')) { + def sub_string = schema_value.replace('\$projectDir', '') + sub_string = sub_string.replace('\${projectDir}', '') + if (params_value.contains(sub_string)) { + schema_value = params_value + } + } + if (schema_value.contains('$params.outdir') || schema_value.contains('${params.outdir}')) { + def sub_string = schema_value.replace('\$params.outdir', '') + sub_string = sub_string.replace('\${params.outdir}', '') + if ("${params.outdir}${sub_string}" == params_value) { + schema_value = params_value + } + } + } + } + + // We have a default in the schema, and this isn't it + if (schema_value != null && params_value != schema_value) { + sub_params.put(param, params_value) + } + // No default in the schema, and this isn't empty + else if (schema_value == null && params_value != "" && params_value != null && params_value != false) { + sub_params.put(param, params_value) + } + } + } + params_summary.put(group, sub_params) + } + return [ 'Core Nextflow options' : workflow_summary ] << params_summary + } + + // + // Beautify parameters for summary and return as string + // + public static String paramsSummaryLog(workflow, params) { + Map colors = NfcoreTemplate.logColours(params.monochrome_logs) + String output = '' + def params_map = paramsSummaryMap(workflow, params) + def max_chars = paramsMaxChars(params_map) + for (group in params_map.keySet()) { + def group_params = params_map.get(group) // This gets the parameters of that particular group + if (group_params) { + output += colors.bold + group + colors.reset + '\n' + for (param in group_params.keySet()) { + output += " " + colors.blue + param.padRight(max_chars) + ": " + colors.green + group_params.get(param) + colors.reset + '\n' + } + output += '\n' + } + } + output += "!! Only displaying parameters that differ from the pipeline defaults !!\n" + output += NfcoreTemplate.dashedLine(params.monochrome_logs) + return output + } + + // + // Loop over nested exceptions and print the causingException + // + private static void printExceptions(ex_json, params_json, log) { + def causingExceptions = ex_json['causingExceptions'] + if (causingExceptions.length() == 0) { + def m = ex_json['message'] =~ /required key \[([^\]]+)\] not found/ + // Missing required param + if (m.matches()) { + log.error "* Missing required parameter: --${m[0][1]}" + } + // Other base-level error + else if (ex_json['pointerToViolation'] == '#') { + log.error "* ${ex_json['message']}" + } + // Error with specific param + else { + def param = ex_json['pointerToViolation'] - ~/^#\// + def param_val = params_json[param].toString() + log.error "* --${param}: ${ex_json['message']} (${param_val})" + } + } + for (ex in causingExceptions) { + printExceptions(ex, params_json, log) + } + } + + // + // Remove an element from a JSONArray + // + private static JSONArray removeElement(json_array, element) { + def list = [] + int len = json_array.length() + for (int i=0;i + if(raw_schema.keySet().contains('definitions')){ + raw_schema.definitions.each { definition -> + for (key in definition.keySet()){ + if (definition[key].get("properties").keySet().contains(ignore_param)){ + // Remove the param to ignore + definition[key].get("properties").remove(ignore_param) + // If the param was required, change this + if (definition[key].has("required")) { + def cleaned_required = removeElement(definition[key].required, ignore_param) + definition[key].put("required", cleaned_required) + } + } + } + } + } + if(raw_schema.keySet().contains('properties') && raw_schema.get('properties').keySet().contains(ignore_param)) { + raw_schema.get("properties").remove(ignore_param) + } + if(raw_schema.keySet().contains('required') && raw_schema.required.contains(ignore_param)) { + def cleaned_required = removeElement(raw_schema.required, ignore_param) + raw_schema.put("required", cleaned_required) + } + } + return raw_schema + } + + // + // Clean and check parameters relative to Nextflow native classes + // + private static Map cleanParameters(params) { + def new_params = params.getClass().newInstance(params) + for (p in params) { + // remove anything evaluating to false + if (!p['value']) { + new_params.remove(p.key) + } + // Cast MemoryUnit to String + if (p['value'].getClass() == nextflow.util.MemoryUnit) { + new_params.replace(p.key, p['value'].toString()) + } + // Cast Duration to String + if (p['value'].getClass() == nextflow.util.Duration) { + new_params.replace(p.key, p['value'].toString().replaceFirst(/d(?!\S)/, "day")) + } + // Cast LinkedHashMap to String + if (p['value'].getClass() == LinkedHashMap) { + new_params.replace(p.key, p['value'].toString()) + } + } + return new_params + } + + // + // This function tries to read a JSON params file + // + private static LinkedHashMap paramsLoad(String json_schema) { + def params_map = new LinkedHashMap() + try { + params_map = paramsRead(json_schema) + } catch (Exception e) { + println "Could not read parameters settings from JSON. $e" + params_map = new LinkedHashMap() + } + return params_map + } + + // + // Method to actually read in JSON file using Groovy. + // Group (as Key), values are all parameters + // - Parameter1 as Key, Description as Value + // - Parameter2 as Key, Description as Value + // .... + // Group + // - + private static LinkedHashMap paramsRead(String json_schema) throws Exception { + def json = new File(json_schema).text + def Map schema_definitions = (Map) new JsonSlurper().parseText(json).get('definitions') + def Map schema_properties = (Map) new JsonSlurper().parseText(json).get('properties') + /* Tree looks like this in nf-core schema + * definitions <- this is what the first get('definitions') gets us + group 1 + title + description + properties + parameter 1 + type + description + parameter 2 + type + description + group 2 + title + description + properties + parameter 1 + type + description + * properties <- parameters can also be ungrouped, outside of definitions + parameter 1 + type + description + */ + + // Grouped params + def params_map = new LinkedHashMap() + schema_definitions.each { key, val -> + def Map group = schema_definitions."$key".properties // Gets the property object of the group + def title = schema_definitions."$key".title + def sub_params = new LinkedHashMap() + group.each { innerkey, value -> + sub_params.put(innerkey, value) + } + params_map.put(title, sub_params) + } + + // Ungrouped params + def ungrouped_params = new LinkedHashMap() + schema_properties.each { innerkey, value -> + ungrouped_params.put(innerkey, value) + } + params_map.put("Other parameters", ungrouped_params) + + return params_map + } + + // + // Get maximum number of characters across all parameter names + // + private static Integer paramsMaxChars(params_map) { + Integer max_chars = 0 + for (group in params_map.keySet()) { + def group_params = params_map.get(group) // This gets the parameters of that particular group + for (param in group_params.keySet()) { + if (param.size() > max_chars) { + max_chars = param.size() + } + } + } + return max_chars + } +} diff --git a/lib/NfcoreTemplate.groovy b/lib/NfcoreTemplate.groovy new file mode 100755 index 000000000..44551e0a3 --- /dev/null +++ b/lib/NfcoreTemplate.groovy @@ -0,0 +1,270 @@ +// +// This file holds several functions used within the nf-core pipeline template. +// + +import org.yaml.snakeyaml.Yaml + +class NfcoreTemplate { + + // + // Check AWS Batch related parameters have been specified correctly + // + public static void awsBatch(workflow, params) { + if (workflow.profile.contains('awsbatch')) { + // Check params.awsqueue and params.awsregion have been set if running on AWSBatch + assert (params.awsqueue && params.awsregion) : "Specify correct --awsqueue and --awsregion parameters on AWSBatch!" + // Check outdir paths to be S3 buckets if running on AWSBatch + assert params.outdir.startsWith('s3:') : "Outdir not on S3 - specify S3 Bucket to run on AWSBatch!" + } + } + + // + // Check params.hostnames + // + public static void hostName(workflow, params, log) { + Map colors = logColours(params.monochrome_logs) + if (params.hostnames) { + try { + def hostname = "hostname".execute().text.trim() + params.hostnames.each { prof, hnames -> + hnames.each { hname -> + if (hostname.contains(hname) && !workflow.profile.contains(prof)) { + log.info "=${colors.yellow}====================================================${colors.reset}=\n" + + "${colors.yellow}WARN: You are running with `-profile $workflow.profile`\n" + + " but your machine hostname is ${colors.white}'$hostname'${colors.reset}.\n" + + " ${colors.yellow_bold}Please use `-profile $prof${colors.reset}`\n" + + "=${colors.yellow}====================================================${colors.reset}=" + } + } + } + } catch (Exception e) { + log.warn "[$workflow.manifest.name] Could not determine 'hostname' - skipping check. Reason: ${e.message}." + } + } + } + + // + // Construct and send completion email + // + public static void email(workflow, params, summary_params, projectDir, log, multiqc_report=[]) { + + // Set up the e-mail variables + def subject = "[$workflow.manifest.name] Successful: $workflow.runName" + if (!workflow.success) { + subject = "[$workflow.manifest.name] FAILED: $workflow.runName" + } + + def summary = [:] + for (group in summary_params.keySet()) { + summary << summary_params[group] + } + + def misc_fields = [:] + misc_fields['Date Started'] = workflow.start + misc_fields['Date Completed'] = workflow.complete + misc_fields['Pipeline script file path'] = workflow.scriptFile + misc_fields['Pipeline script hash ID'] = workflow.scriptId + if (workflow.repository) misc_fields['Pipeline repository Git URL'] = workflow.repository + if (workflow.commitId) misc_fields['Pipeline repository Git Commit'] = workflow.commitId + if (workflow.revision) misc_fields['Pipeline Git branch/tag'] = workflow.revision + misc_fields['Nextflow Version'] = workflow.nextflow.version + misc_fields['Nextflow Build'] = workflow.nextflow.build + misc_fields['Nextflow Compile Timestamp'] = workflow.nextflow.timestamp + + def email_fields = [:] + email_fields['version'] = workflow.manifest.version + email_fields['runName'] = workflow.runName + email_fields['success'] = workflow.success + email_fields['dateComplete'] = workflow.complete + email_fields['duration'] = workflow.duration + email_fields['exitStatus'] = workflow.exitStatus + email_fields['errorMessage'] = (workflow.errorMessage ?: 'None') + email_fields['errorReport'] = (workflow.errorReport ?: 'None') + email_fields['commandLine'] = workflow.commandLine + email_fields['projectDir'] = workflow.projectDir + email_fields['summary'] = summary << misc_fields + + // On success try attach the multiqc report + def mqc_report = null + try { + if (workflow.success) { + mqc_report = multiqc_report.getVal() + if (mqc_report.getClass() == ArrayList && mqc_report.size() >= 1) { + if (mqc_report.size() > 1) { + log.warn "[$workflow.manifest.name] Found multiple reports from process 'MULTIQC', will use only one" + } + mqc_report = mqc_report[0] + } + } + } catch (all) { + if (multiqc_report) { + log.warn "[$workflow.manifest.name] Could not attach MultiQC report to summary email" + } + } + + // Check if we are only sending emails on failure + def email_address = params.email + if (!params.email && params.email_on_fail && !workflow.success) { + email_address = params.email_on_fail + } + + // Render the TXT template + def engine = new groovy.text.GStringTemplateEngine() + def tf = new File("$projectDir/assets/email_template.txt") + def txt_template = engine.createTemplate(tf).make(email_fields) + def email_txt = txt_template.toString() + + // Render the HTML template + def hf = new File("$projectDir/assets/email_template.html") + def html_template = engine.createTemplate(hf).make(email_fields) + def email_html = html_template.toString() + + // Render the sendmail template + def max_multiqc_email_size = params.max_multiqc_email_size as nextflow.util.MemoryUnit + def smail_fields = [ email: email_address, subject: subject, email_txt: email_txt, email_html: email_html, projectDir: "$projectDir", mqcFile: mqc_report, mqcMaxSize: max_multiqc_email_size.toBytes() ] + def sf = new File("$projectDir/assets/sendmail_template.txt") + def sendmail_template = engine.createTemplate(sf).make(smail_fields) + def sendmail_html = sendmail_template.toString() + + // Send the HTML e-mail + Map colors = logColours(params.monochrome_logs) + if (email_address) { + try { + if (params.plaintext_email) { throw GroovyException('Send plaintext e-mail, not HTML') } + // Try to send HTML e-mail using sendmail + [ 'sendmail', '-t' ].execute() << sendmail_html + log.info "-${colors.purple}[$workflow.manifest.name]${colors.green} Sent summary e-mail to $email_address (sendmail)-" + } catch (all) { + // Catch failures and try with plaintext + def mail_cmd = [ 'mail', '-s', subject, '--content-type=text/html', email_address ] + if ( mqc_report.size() <= max_multiqc_email_size.toBytes() ) { + mail_cmd += [ '-A', mqc_report ] + } + mail_cmd.execute() << email_html + log.info "-${colors.purple}[$workflow.manifest.name]${colors.green} Sent summary e-mail to $email_address (mail)-" + } + } + + // Write summary e-mail HTML to a file + def output_d = new File("${params.outdir}/pipeline_info/") + if (!output_d.exists()) { + output_d.mkdirs() + } + def output_hf = new File(output_d, "pipeline_report.html") + output_hf.withWriter { w -> w << email_html } + def output_tf = new File(output_d, "pipeline_report.txt") + output_tf.withWriter { w -> w << email_txt } + } + + // + // Print pipeline summary on completion + // + public static void summary(workflow, params, log) { + Map colors = logColours(params.monochrome_logs) + if (workflow.success) { + if (workflow.stats.ignoredCount == 0) { + log.info "-${colors.purple}[$workflow.manifest.name]${colors.green} Pipeline completed successfully${colors.reset}-" + } else { + log.info "-${colors.purple}[$workflow.manifest.name]${colors.red} Pipeline completed successfully, but with errored process(es) ${colors.reset}-" + } + } else { + hostName(workflow, params, log) + log.info "-${colors.purple}[$workflow.manifest.name]${colors.red} Pipeline completed with errors${colors.reset}-" + } + } + + // + // ANSII Colours used for terminal logging + // + public static Map logColours(Boolean monochrome_logs) { + Map colorcodes = [:] + + // Reset / Meta + colorcodes['reset'] = monochrome_logs ? '' : "\033[0m" + colorcodes['bold'] = monochrome_logs ? '' : "\033[1m" + colorcodes['dim'] = monochrome_logs ? '' : "\033[2m" + colorcodes['underlined'] = monochrome_logs ? '' : "\033[4m" + colorcodes['blink'] = monochrome_logs ? '' : "\033[5m" + colorcodes['reverse'] = monochrome_logs ? '' : "\033[7m" + colorcodes['hidden'] = monochrome_logs ? '' : "\033[8m" + + // Regular Colors + colorcodes['black'] = monochrome_logs ? '' : "\033[0;30m" + colorcodes['red'] = monochrome_logs ? '' : "\033[0;31m" + colorcodes['green'] = monochrome_logs ? '' : "\033[0;32m" + colorcodes['yellow'] = monochrome_logs ? '' : "\033[0;33m" + colorcodes['blue'] = monochrome_logs ? '' : "\033[0;34m" + colorcodes['purple'] = monochrome_logs ? '' : "\033[0;35m" + colorcodes['cyan'] = monochrome_logs ? '' : "\033[0;36m" + colorcodes['white'] = monochrome_logs ? '' : "\033[0;37m" + + // Bold + colorcodes['bblack'] = monochrome_logs ? '' : "\033[1;30m" + colorcodes['bred'] = monochrome_logs ? '' : "\033[1;31m" + colorcodes['bgreen'] = monochrome_logs ? '' : "\033[1;32m" + colorcodes['byellow'] = monochrome_logs ? '' : "\033[1;33m" + colorcodes['bblue'] = monochrome_logs ? '' : "\033[1;34m" + colorcodes['bpurple'] = monochrome_logs ? '' : "\033[1;35m" + colorcodes['bcyan'] = monochrome_logs ? '' : "\033[1;36m" + colorcodes['bwhite'] = monochrome_logs ? '' : "\033[1;37m" + + // Underline + colorcodes['ublack'] = monochrome_logs ? '' : "\033[4;30m" + colorcodes['ured'] = monochrome_logs ? '' : "\033[4;31m" + colorcodes['ugreen'] = monochrome_logs ? '' : "\033[4;32m" + colorcodes['uyellow'] = monochrome_logs ? '' : "\033[4;33m" + colorcodes['ublue'] = monochrome_logs ? '' : "\033[4;34m" + colorcodes['upurple'] = monochrome_logs ? '' : "\033[4;35m" + colorcodes['ucyan'] = monochrome_logs ? '' : "\033[4;36m" + colorcodes['uwhite'] = monochrome_logs ? '' : "\033[4;37m" + + // High Intensity + colorcodes['iblack'] = monochrome_logs ? '' : "\033[0;90m" + colorcodes['ired'] = monochrome_logs ? '' : "\033[0;91m" + colorcodes['igreen'] = monochrome_logs ? '' : "\033[0;92m" + colorcodes['iyellow'] = monochrome_logs ? '' : "\033[0;93m" + colorcodes['iblue'] = monochrome_logs ? '' : "\033[0;94m" + colorcodes['ipurple'] = monochrome_logs ? '' : "\033[0;95m" + colorcodes['icyan'] = monochrome_logs ? '' : "\033[0;96m" + colorcodes['iwhite'] = monochrome_logs ? '' : "\033[0;97m" + + // Bold High Intensity + colorcodes['biblack'] = monochrome_logs ? '' : "\033[1;90m" + colorcodes['bired'] = monochrome_logs ? '' : "\033[1;91m" + colorcodes['bigreen'] = monochrome_logs ? '' : "\033[1;92m" + colorcodes['biyellow'] = monochrome_logs ? '' : "\033[1;93m" + colorcodes['biblue'] = monochrome_logs ? '' : "\033[1;94m" + colorcodes['bipurple'] = monochrome_logs ? '' : "\033[1;95m" + colorcodes['bicyan'] = monochrome_logs ? '' : "\033[1;96m" + colorcodes['biwhite'] = monochrome_logs ? '' : "\033[1;97m" + + return colorcodes + } + + // + // Does what is says on the tin + // + public static String dashedLine(monochrome_logs) { + Map colors = logColours(monochrome_logs) + return "-${colors.dim}----------------------------------------------------${colors.reset}-" + } + + // + // nf-core logo + // + public static String logo(workflow, monochrome_logs) { + Map colors = logColours(monochrome_logs) + String.format( + """\n + ${dashedLine(monochrome_logs)} + ${colors.green},--.${colors.black}/${colors.green},-.${colors.reset} + ${colors.blue} ___ __ __ __ ___ ${colors.green}/,-._.--~\'${colors.reset} + ${colors.blue} |\\ | |__ __ / ` / \\ |__) |__ ${colors.yellow}} {${colors.reset} + ${colors.blue} | \\| | \\__, \\__/ | \\ |___ ${colors.green}\\`-._,-`-,${colors.reset} + ${colors.green}`._,._,\'${colors.reset} + ${colors.purple} ${workflow.manifest.name} v${workflow.manifest.version}${colors.reset} + ${dashedLine(monochrome_logs)} + """.stripIndent() + ) + } +} diff --git a/lib/Utils.groovy b/lib/Utils.groovy new file mode 100755 index 000000000..18173e985 --- /dev/null +++ b/lib/Utils.groovy @@ -0,0 +1,47 @@ +// +// This file holds several Groovy functions that could be useful for any Nextflow pipeline +// + +import org.yaml.snakeyaml.Yaml + +class Utils { + + // + // When running with -profile conda, warn if channels have not been set-up appropriately + // + public static void checkCondaChannels(log) { + Yaml parser = new Yaml() + def channels = [] + try { + def config = parser.load("conda config --show channels".execute().text) + channels = config.channels + } catch(NullPointerException | IOException e) { + log.warn "Could not verify conda channel configuration." + return + } + + // Check that all channels are present + def required_channels = ['conda-forge', 'bioconda', 'defaults'] + def conda_check_failed = !required_channels.every { ch -> ch in channels } + + // Check that they are in the right order + conda_check_failed |= !(channels.indexOf('conda-forge') < channels.indexOf('bioconda')) + conda_check_failed |= !(channels.indexOf('bioconda') < channels.indexOf('defaults')) + + if (conda_check_failed) { + log.warn "=============================================================================\n" + + " There is a problem with your Conda configuration!\n\n" + + " You will need to set-up the conda-forge and bioconda channels correctly.\n" + + " Please refer to https://bioconda.github.io/user/install.html#set-up-channels\n" + + " NB: The order of the channels matters!\n" + + "===================================================================================" + } + } + + // + // Join module args with appropriate spacing + // + public static String joinModuleArgs(args_list) { + return ' ' + args_list.join(' ') + } +} diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy new file mode 100755 index 000000000..02304f9d9 --- /dev/null +++ b/lib/WorkflowChipseq.groovy @@ -0,0 +1,74 @@ +// +// This file holds several functions specific to the workflow/chipseq.nf in the nf-core/chipseq pipeline +// + +class WorkflowChipseq { + + // + // Check and validate parameters + // + public static void initialise(params, log) { + genomeExistsError(params, log) + macs2_warn(params, log) + + if (!params.fasta) { + log.error "Genome fasta file not specified with e.g. '--fasta genome.fa' or via a detectable config file." + System.exit(1) + } + } + + // + // Get workflow summary for MultiQC + // + public static String paramsSummaryMultiqc(workflow, summary) { + String summary_section = '' + for (group in summary.keySet()) { + def group_params = summary.get(group) // This gets the parameters of that particular group + if (group_params) { + summary_section += "

$group

\n" + summary_section += " \n" + } + } + + String yaml_file_text = "id: '${workflow.manifest.name.replace('/','-')}-summary'\n" + yaml_file_text += "description: ' - this information is collected when the pipeline is started.'\n" + yaml_file_text += "section_name: '${workflow.manifest.name} Workflow Summary'\n" + yaml_file_text += "section_href: 'https://github.com/${workflow.manifest.name}'\n" + yaml_file_text += "plot_type: 'html'\n" + yaml_file_text += "data: |\n" + yaml_file_text += "${summary_section}" + return yaml_file_text + } + + // + // Exit pipeline if incorrect --genome key provided + // + private static void genomeExistsError(params, log) { + if (params.genomes && params.genome && !params.genomes.containsKey(params.genome)) { + log.error "=============================================================================\n" + + " Genome '${params.genome}' not found in any config files provided to the pipeline.\n" + + " Currently, the available genome keys are:\n" + + " ${params.genomes.keySet().join(", ")}\n" + + "===================================================================================" + System.exit(1) + } + } + + // + // Show a big warning message if we're not running MACS + // + private static void macs2_warn(params, log) { + if (!params.macs_gsize) { + def warnstring = params.genome ? "supported for '${params.genome}'" : 'supplied' + log.warn "=================================================================\n" + + " WARNING! MACS genome size parameter not $warnstring.\n" + + " Peak calling, annotation and differential analysis will be skipped.\n" + + " Please specify value for '--macs_gsize' to run these steps.\n" + + "=======================================================================" + } + } +} diff --git a/lib/WorkflowMain.groovy b/lib/WorkflowMain.groovy new file mode 100755 index 000000000..bc960fcc8 --- /dev/null +++ b/lib/WorkflowMain.groovy @@ -0,0 +1,94 @@ +// +// This file holds several functions specific to the main.nf workflow in the nf-core/chipseq pipeline +// + +class WorkflowMain { + + // + // Citation string for pipeline + // + public static String citation(workflow) { + return "If you use ${workflow.manifest.name} for your analysis please cite:\n\n" + + // TODO nf-core: Add Zenodo DOI for pipeline after first release + //"* The pipeline\n" + + //" https://doi.org/10.5281/zenodo.XXXXXXX\n\n" + + "* The nf-core framework\n" + + " https://doi.org/10.1038/s41587-020-0439-x\n\n" + + "* Software dependencies\n" + + " https://github.com/${workflow.manifest.name}/blob/master/CITATIONS.md" + } + + // + // Print help to screen if required + // + public static String help(workflow, params, log) { + def command = "nextflow run ${workflow.manifest.name} --input samplesheet.csv --genome GRCh37 -profile docker" + def help_string = '' + help_string += NfcoreTemplate.logo(workflow, params.monochrome_logs) + help_string += NfcoreSchema.paramsHelp(workflow, params, command) + help_string += '\n' + citation(workflow) + '\n' + help_string += NfcoreTemplate.dashedLine(params.monochrome_logs) + return help_string + } + + // + // Print parameter summary log to screen + // + public static String paramsSummaryLog(workflow, params, log) { + def summary_log = '' + summary_log += NfcoreTemplate.logo(workflow, params.monochrome_logs) + summary_log += NfcoreSchema.paramsSummaryLog(workflow, params) + summary_log += '\n' + citation(workflow) + '\n' + summary_log += NfcoreTemplate.dashedLine(params.monochrome_logs) + return summary_log + } + + // + // Validate parameters and print summary to screen + // + public static void initialise(workflow, params, log) { + // Print help to screen if required + if (params.help) { + log.info help(workflow, params, log) + System.exit(0) + } + + // Validate workflow parameters via the JSON schema + if (params.validate_params) { + NfcoreSchema.validateParameters(workflow, params, log) + } + + // Print parameter summary log to screen + log.info paramsSummaryLog(workflow, params, log) + + // Check that conda channels are set-up correctly + if (params.enable_conda) { + Utils.checkCondaChannels(log) + } + + // Check AWS batch settings + NfcoreTemplate.awsBatch(workflow, params) + + // Check the hostnames against configured profiles + NfcoreTemplate.hostName(workflow, params, log) + + // Check input has been provided + if (!params.input) { + log.error "Please provide an input samplesheet to the pipeline e.g. '--input samplesheet.csv'" + System.exit(1) + } + } + + // + // Get attribute from genome config file e.g. fasta + // + public static String getGenomeAttribute(params, attribute) { + def val = '' + if (params.genomes && params.genome && params.genomes.containsKey(params.genome)) { + if (params.genomes[ params.genome ].containsKey(attribute)) { + val = params.genomes[ params.genome ][ attribute ] + } + } + return val + } +} diff --git a/lib/nfcore_external_java_deps.jar b/lib/nfcore_external_java_deps.jar new file mode 100644 index 0000000000000000000000000000000000000000..805c8bb5e4fd43a12a5891eea5a68788309629b0 GIT binary patch literal 2291171 zcma%i1CS<7mu}m(-Ea4_?dhK8v~AnAZQHhO+qP}n-E-&Lf8*Yb{bM(7MpZ;s){{|L znGpxiIY(9k6buar3JMCSNkdW|=)W{*ATS^)VMTsgF=-L{?{Od?P#{?eNT`1hApZ%I z{U0Zz{YCuW$x{5%Vj{u{igZ#U4^op8k`lCZbMO+hRMV3)4e|_&%)3YSbmCGpVp4NX zni_mKLGakt&P12{r^KCD0GPa9sIuy`fu+agt?8O-hY9i{WloGe}y@kSsDEY_Fud9 z-?2ab4J)MQXe4E3Xl-U<>PRMQZ)0m@@90KnV5#Te5Tz`pvZ0Lj4F<9%Flh(`Qb;Tn 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nf-core/chipseq Analysis Pipeline. - #### Homepage / Documentation - https://github.com/nf-core/chipseq + Github : https://github.com/nf-core/chipseq + Website: https://nf-co.re/chipseq + Slack : https://nfcore.slack.com/channels/chipseq ---------------------------------------------------------------------------------------- */ nextflow.enable.dsl = 2 /* - * Print help message if required - */ -if (params.help) { - def command = "nextflow run nf-core/chipseq --input design.csv --genome GRCh37 -profile docker" - log.info Headers.nf_core(workflow, params.monochrome_logs) - log.info Schema.params_help("$projectDir/nextflow_schema.json", command) - exit 0 -} +======================================================================================== + GENOME PARAMETER VALUES +======================================================================================== +*/ -//////////////////////////////////////////////////// -/* -- DEFAULT PARAMETER VALUES -- */ -//////////////////////////////////////////////////// +params.fasta = WorkflowMain.getGenomeAttribute(params, 'fasta') +params.bwa_index = WorkflowMain.getGenomeAttribute(params, 'bwa') +params.gtf = WorkflowMain.getGenomeAttribute(params, 'gtf') +params.gene_bed = WorkflowMain.getGenomeAttribute(params, 'gene_bed') +params.macs_gsize = WorkflowMain.getGenomeAttribute(params, 'macs_gsize') +params.blacklist = WorkflowMain.getGenomeAttribute(params, 'blacklist') +params.readme = WorkflowMain.getGenomeAttribute(params, 'readme') /* - * Reference genomes - */ -// Check if genome exists in the config file -if (params.genomes && params.genome && !params.genomes.containsKey(params.genome)) { - exit 1, "The provided genome '${params.genome}' is not available in the iGenomes file. Currently the available genomes are ${params.genomes.keySet().join(", ")}" -} - -// Configurable variables -params.fasta = params.genome ? params.genomes[ params.genome ].fasta ?: false : false -params.bwa_index = params.genome ? params.genomes[ params.genome ].bwa ?: false : false -params.gtf = params.genome ? params.genomes[ params.genome ].gtf ?: false : false -params.gene_bed = params.genome ? params.genomes[ params.genome ].bed12 ?: false : false -params.macs_gsize = params.genome ? params.genomes[ params.genome ].macs_gsize ?: false : false -params.blacklist = params.genome ? params.genomes[ params.genome ].blacklist ?: false : false -anno_readme = params.genome ? params.genomes[ params.genome ].readme ?: false : false +======================================================================================== + VALIDATE & PRINT PARAMETER SUMMARY +======================================================================================== +*/ -//////////////////////////////////////////////////// -/* -- VALIDATE INPUTS -- */ -//////////////////////////////////////////////////// +WorkflowMain.initialise(workflow, params, log) /* - * Validate parameters - */ -if (params.input) { ch_input = file(params.input, checkIfExists: true) } else { exit 1, 'Samples design file not specified!' } -if (params.gtf) { ch_gtf = file(params.gtf, checkIfExists: true) } else { exit 1, 'GTF annotation file not specified!' } -if (params.gene_bed) { ch_gene_bed = file(params.gene_bed, checkIfExists: true) } -if (params.blacklist) { ch_blacklist = Channel.fromPath(params.blacklist, checkIfExists: true) } else { ch_blacklist = Channel.empty() } - -if (params.fasta) { - ch_fasta = file(params.fasta, checkIfExists: true) -} else { - exit 1, 'Fasta file not specified!' -} +======================================================================================== + NAMED WORKFLOW FOR PIPELINE +======================================================================================== +*/ -// Save AWS IGenomes file containing annotation version -if (anno_readme && file(anno_readme).exists()) { - file("${params.outdir}/genome/").mkdirs() - file(anno_readme).copyTo("${params.outdir}/genome/") -} +include { CHIPSEQ } from './workflows/chipseq' -// If --gtf is supplied along with --genome -// Make gene bed from supplied --gtf instead of using iGenomes one automatically -def makeBED = false -if (!params.gene_bed) { - makeBED = true -} else if (params.genome && params.gtf) { - if (params.genomes[ params.genome ].gtf != params.gtf) { - makeBED = true - } +// +// WORKFLOW: Run main nf-core/chipseq analysis pipeline +// +workflow NFCORE_CHIPSEQ { + CHIPSEQ () } /* - * Check parameters - */ -Checks.aws_batch(workflow, params) // Check AWS batch settings -Checks.hostname(workflow, params, log) // Check the hostnames against configured profiles -Checks.macs2_warn(params, log) // Show a big warning message if we're not running MACS - -//////////////////////////////////////////////////// -/* -- CONFIG FILES -- */ -//////////////////////////////////////////////////// - -/* - * Stage config files - */ -ch_multiqc_config = file("$projectDir/assets/multiqc_config.yaml", checkIfExists: true) -ch_multiqc_custom_config = params.multiqc_config ? Channel.fromPath(params.multiqc_config, checkIfExists: true) : Channel.empty() -ch_output_docs = file("$projectDir/docs/output.md", checkIfExists: true) -ch_output_docs_images = file("$projectDir/docs/images/", checkIfExists: true) - -// JSON files required by BAMTools for alignment filtering -ch_bamtools_filter_se_config = file(params.bamtools_filter_se_config, checkIfExists: true) -ch_bamtools_filter_pe_config = file(params.bamtools_filter_pe_config, checkIfExists: true) - -// Header files for MultiQC -ch_spp_nsc_header = file("$projectDir/assets/multiqc/spp_nsc_header.txt", checkIfExists: true) -ch_spp_rsc_header = file("$projectDir/assets/multiqc/spp_rsc_header.txt", checkIfExists: true) -ch_spp_correlation_header = file("$projectDir/assets/multiqc/spp_correlation_header.txt", checkIfExists: true) -ch_peak_count_header = file("$projectDir/assets/multiqc/peak_count_header.txt", checkIfExists: true) -ch_frip_score_header = file("$projectDir/assets/multiqc/frip_score_header.txt", checkIfExists: true) -ch_peak_annotation_header = file("$projectDir/assets/multiqc/peak_annotation_header.txt", checkIfExists: true) -ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) -ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) - -//////////////////////////////////////////////////// -/* -- PARAMETER SUMMARY -- */ -//////////////////////////////////////////////////// - -/* - * Print parameter summary - */ -// Has the run name been specified by the user? -// this has the bonus effect of catching both -name and --name -run_name = params.name -if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { - run_name = workflow.runName -} -summary = Schema.params_summary(workflow, params, run_name) -log.info Headers.nf_core(workflow, params.monochrome_logs) -log.info summary.collect { k,v -> "${k.padRight(22)}: $v" }.join("\n") -log.info "-\033[2m----------------------------------------------------\033[0m-" - -//////////////////////////////////////////////////// -/* -- IMPORT LOCAL MODULES/SUBWORKFLOWS -- */ -//////////////////////////////////////////////////// - -include { GTF2BED } from './modules/local/process/gtf2bed' -include { GET_CHROM_SIZES } from './modules/local/process/get_chrom_sizes' -include { MAKE_GENOME_FILTER } from './modules/local/process/make_genome_filter' -include { BEDTOOLS_GENOMECOV } from './modules/local/process/bedtools_genomecov' -include { PLOT_HOMER_ANNOTATEPEAKS } from './modules/local/process/plot_homer_annotatepeaks' -include { PLOT_MACS2_QC } from './modules/local/process/plot_macs2_qc' -include { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS } from './modules/local/process/multiqc_custom_phantompeakqualtools' -include { MULTIQC_CUSTOM_PEAKS } from './modules/local/process/multiqc_custom_peaks' -include { MACS2_CONSENSUS } from './modules/local/process/macs2_consensus' -include { FRIP_SCORE } from './modules/local/process/frip_score' -//include { DESEQ2_FEATURECOUNTS } from './modules/local/process/deseq2_featurecounts' -include { IGV } from './modules/local/process/igv' -include { OUTPUT_DOCUMENTATION } from './modules/local/process/output_documentation' -include { GET_SOFTWARE_VERSIONS } from './modules/local/process/get_software_versions' -include { MULTIQC } from './modules/local/process/multiqc' - -include { INPUT_CHECK } from './modules/local/subworkflow/input_check' -include { BAM_CLEAN } from './modules/local/subworkflow/bam_clean' - -//////////////////////////////////////////////////// -/* -- IMPORT NF-CORE MODULES/SUBWORKFLOWS -- */ -//////////////////////////////////////////////////// - -include { BWA_INDEX } from './modules/nf-core/software/bwa/index/main' -include { PICARD_MERGESAMFILES } from './modules/nf-core/software/picard/mergesamfiles/main' -include { PICARD_COLLECTMULTIPLEMETRICS } from './modules/nf-core/software/picard/collectmultiplemetrics/main' -include { PRESEQ_LCEXTRAP } from './modules/nf-core/software/preseq/lcextrap/main' -include { UCSC_BEDRAPHTOBIGWIG } from './modules/nf-core/software/ucsc/bedgraphtobigwig/main' -include { DEEPTOOLS_COMPUTEMATRIX } from './modules/nf-core/software/deeptools/computematrix/main' -include { DEEPTOOLS_PLOTPROFILE } from './modules/nf-core/software/deeptools/plotprofile/main' -include { DEEPTOOLS_PLOTHEATMAP } from './modules/nf-core/software/deeptools/plotheatmap/main' -include { DEEPTOOLS_PLOTFINGERPRINT } from './modules/nf-core/software/deeptools/plotfingerprint/main' -include { PHANTOMPEAKQUALTOOLS } from './modules/nf-core/software/phantompeakqualtools/main' -include { MACS2_CALLPEAK } from './modules/nf-core/software/macs2/callpeak/main' -include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 - HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from './modules/nf-core/software/homer/annotatepeaks/main' -include { SUBREAD_FEATURECOUNTS } from './modules/nf-core/software/subread/featurecounts/main' - -include { FASTQC_TRIMGALORE } from './modules/nf-core/subworkflow/fastqc_trimgalore' -include { MAP_BWA_MEM } from './modules/nf-core/subworkflow/map_bwa_mem' -include { MARK_DUPLICATES_PICARD } from './modules/nf-core/subworkflow/mark_duplicates_picard' - -//////////////////////////////////////////////////// -/* -- RUN MAIN WORKFLOW -- */ -//////////////////////////////////////////////////// +======================================================================================== + RUN ALL WORKFLOWS +======================================================================================== +*/ +// +// WORKFLOW: Execute a single named workflow for the pipeline +// See: https://github.com/nf-core/rnaseq/issues/619 +// workflow { - - /* - * Read in samplesheet, validate and stage input files - */ - INPUT_CHECK ( - ch_input, - params.seq_center, - [:] - ) - - /* - * Prepare genome files - */ - ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta, params.modules['bwa_index'] ).index - - if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf, [:] ) } - - MAKE_GENOME_FILTER ( - GET_CHROM_SIZES ( ch_fasta, [:] ).sizes, - ch_blacklist.ifEmpty([]), - [:] - ) - ch_software_versions = Channel.empty() - ch_software_versions = ch_software_versions.mix(MAKE_GENOME_FILTER.out.version.first().ifEmpty(null)) - - /* - * Read QC & trimming - */ - nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' - params.modules['trimgalore'].args += nextseq - FASTQC_TRIMGALORE ( - INPUT_CHECK.out.reads, - params.skip_fastqc, - params.skip_trimming, - params.modules['fastqc'], - params.modules['trimgalore'] - ) - ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.fastqc_version.first().ifEmpty(null)) - ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.trimgalore_version.first().ifEmpty(null)) - - /* - * Map reads & BAM QC - */ - score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' - params.modules['bwa_mem'].args += score - MAP_BWA_MEM ( - FASTQC_TRIMGALORE.out.reads, - ch_index, - ch_fasta, - params.modules['bwa_mem'], - params.modules['samtools_sort_lib'] - ) - ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.bwa_version.first()) - ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.samtools_version.first().ifEmpty(null)) - - /* - * Merge resequenced BAM files - */ - MAP_BWA_MEM - .out - .bam - .map { - meta, bam -> - fmeta = meta.findAll { it.key != 'read_group' } - fmeta.id = fmeta.id.split('_')[0..-2].join('_') - [ fmeta, bam ] } - .groupTuple(by: [0]) - .map { it -> [ it[0], it[1].flatten() ] } - .set { ch_sort_bam } - - PICARD_MERGESAMFILES ( - ch_sort_bam, - params.modules['picard_mergesamfiles'] - ) - ch_software_versions = ch_software_versions.mix(PICARD_MERGESAMFILES.out.version.first().ifEmpty(null)) - - /* - * Mark duplicates & filter BAM files - */ - MARK_DUPLICATES_PICARD ( - PICARD_MERGESAMFILES.out.bam, - params.modules['picard_markduplicates'], - params.modules['samtools_sort_merged_lib'] - ) - - // Fix getting name sorted BAM here for PE/SE - BAM_CLEAN ( - MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), - MAKE_GENOME_FILTER.out.bed.collect(), - ch_bamtools_filter_se_config, - ch_bamtools_filter_pe_config, - params.modules['bam_filter'], - params.modules['bam_remove_orphans'], - params.modules['samtools_sort_filter'] - ) - ch_software_versions = ch_software_versions.mix(BAM_CLEAN.out.bamtools_version.first().ifEmpty(null)) - - /* - * Post alignment QC - */ - PICARD_COLLECTMULTIPLEMETRICS ( - BAM_CLEAN.out.bam, - ch_fasta, - params.modules['picard_collectmultiplemetrics'] - ) - - PRESEQ_LCEXTRAP ( - BAM_CLEAN.out.bam, - params.modules['preseq_lcextrap'] - ) - ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) - - PHANTOMPEAKQUALTOOLS ( - BAM_CLEAN.out.bam, - params.modules['phantompeakqualtools'] - ) - ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null)) - - MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( - PHANTOMPEAKQUALTOOLS.out.spp.join(PHANTOMPEAKQUALTOOLS.out.rdata, by: [0]), - ch_spp_nsc_header, - ch_spp_rsc_header, - ch_spp_correlation_header, - params.modules['multiqc_custom_phantompeakqualtools'] - ) - - /* - * Coverage tracks - */ - BEDTOOLS_GENOMECOV ( - BAM_CLEAN.out.bam.join(BAM_CLEAN.out.flagstat, by: [0]), - params.modules['bedtools_genomecov'] - ) - - UCSC_BEDRAPHTOBIGWIG ( - BEDTOOLS_GENOMECOV.out.bedgraph, - GET_CHROM_SIZES.out.sizes, - params.modules['ucsc_bedgraphtobigwig'] - ) - ch_software_versions = ch_software_versions.mix(UCSC_BEDRAPHTOBIGWIG.out.version.first().ifEmpty(null)) - - /* - * Coverage plots - */ - DEEPTOOLS_COMPUTEMATRIX ( - UCSC_BEDRAPHTOBIGWIG.out.bigwig, - ch_gene_bed, - params.modules['deeptools_computematrix'] - ) - ch_software_versions = ch_software_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.version.first().ifEmpty(null)) - - DEEPTOOLS_PLOTPROFILE ( - DEEPTOOLS_COMPUTEMATRIX.out.matrix, - params.modules['deeptools_plotprofile'] - ) - - DEEPTOOLS_PLOTHEATMAP ( - DEEPTOOLS_COMPUTEMATRIX.out.matrix, - params.modules['deeptools_plotheatmap'] - ) - - /* - * Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] - */ - BAM_CLEAN - .out - .bam - .join ( BAM_CLEAN.out.bai, by: [0] ) - .map { meta, bam, bai -> meta.control ? null : [ meta.id, [ bam ] , [ bai ] ] } - .set { ch_control_bam_bai } - - BAM_CLEAN - .out - .bam - .join ( BAM_CLEAN.out.bai, by: [0] ) - .map { meta, bam, bai -> meta.control ? [ meta.control, meta, [ bam ], [ bai ] ] : null } - .combine(ch_control_bam_bai, by: 0) - .map { it -> [ it[1] , it[2] + it[4], it[3] + it[5] ] } - .set { ch_ip_control_bam_bai } - - /* - * plotFingerprint for IP and control together - */ - params.modules['deeptools_plotfingerprint'].args += " --numberOfSamples $params.fingerprint_bins" - DEEPTOOLS_PLOTFINGERPRINT ( - ch_ip_control_bam_bai, - params.modules['deeptools_plotfingerprint'] - ) - - peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' - if (params.macs_gsize) { - - /* - * Call peaks - */ - broad = params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}" - pileup = params.save_macs_pileup ? '--bdg --SPMR' : '' - fdr = params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '' - pvalue = params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' - params.modules['macs2_callpeak'].publish_dir += "/$peakType" - params.modules['macs2_callpeak'].args += " $broad $pileup $fdr $pvalue" - - // Create channel: [ val(meta), ip_bam, control_bam ] - ch_ip_control_bam_bai - .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } - .set { ch_ip_control_bam } - - MACS2_CALLPEAK ( - ch_ip_control_bam, - params.macs_gsize, - params.modules['macs2_callpeak'] - ) - ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.version.first().ifEmpty(null)) - - ch_ip_control_bam - .join(MACS2_CALLPEAK.out.peak, by: [0]) - .map { it -> [ it[0], it[1], it[3] ] } - .set { ch_ip_peak } - FRIP_SCORE ( - ch_ip_peak, - params.modules['frip_score'] - ) - - ch_ip_peak - .join(FRIP_SCORE.out.txt, by: [0]) - .map { it -> [ it[0], it[2], it[3] ] } - .set { ch_ip_peak_frip } - MULTIQC_CUSTOM_PEAKS ( - ch_ip_peak_frip, - ch_peak_count_header, - ch_frip_score_header, - params.modules['multiqc_custom_peaks'] - ) - - params.modules['plot_macs2_qc'].publish_dir += "/$peakType/qc" - PLOT_MACS2_QC ( - MACS2_CALLPEAK.out.peak.collect{it[1]}, - params.modules['plot_macs2_qc'] - ) - - params.modules['homer_annotatepeaks_macs2'].publish_dir += "/$peakType" - HOMER_ANNOTATEPEAKS_MACS2 ( - MACS2_CALLPEAK.out.peak, - ch_fasta, - ch_gtf, - params.modules['homer_annotatepeaks_macs2'] - ) - ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.version.first().ifEmpty(null)) - - params.modules['plot_homer_annotatepeaks'].publish_dir += "/$peakType/qc" - PLOT_HOMER_ANNOTATEPEAKS ( - HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, - ch_peak_annotation_header, - "_peaks.annotatePeaks.txt", - params.modules['plot_homer_annotatepeaks'] - ) - - // Create channel: [ meta , [ peaks ] ] - // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] - MACS2_CALLPEAK - .out - .peak - .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } - .groupTuple() - .map { - antibody, groups, peaks -> - [ antibody, - groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, - peaks ] } - .map { - antibody, groups, peaks -> - def meta = [:] - meta.id = antibody - meta.multiple_groups = groups.size() > 1 - meta.replicates_exist = groups.max { groups.value }.value > 1 - [ meta, peaks ] } - .set { ch_antibody_peaks } - - params.modules['macs2_consensus'].publish_dir += "/$peakType/consensus" - MACS2_CONSENSUS ( - ch_antibody_peaks, - params.modules['macs2_consensus'] - ) - - params.modules['homer_annotatepeaks_consensus'].publish_dir += "/$peakType/consensus" - HOMER_ANNOTATEPEAKS_CONSENSUS ( - MACS2_CONSENSUS.out.bed, - ch_fasta, - ch_gtf, - params.modules['homer_annotatepeaks_consensus'] - ) - // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt - // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt - - // Create channel: [ val(meta), ip_bam ] - MACS2_CONSENSUS - .out - .saf - .map { meta, saf -> [ meta.id, meta, saf ] } - .set { ch_ip_saf } - - ch_ip_control_bam - .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } - .combine(ch_ip_saf) - .map { - it -> - fmeta = it[1] - fmeta['replicates_exist'] = it[4]['replicates_exist'] - fmeta['multiple_groups'] = it[4]['multiple_groups'] - [ fmeta, it[2], it[5] ] } - .set { ch_ip_bam } - - params.modules['subread_featurecounts'].publish_dir += "/$peakType/consensus" - SUBREAD_FEATURECOUNTS ( - ch_ip_bam, - params.modules['subread_featurecounts'] - ) - ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) - - // - // DESEQ2_FEATURECOUNTS ( - // params.modules['deseq2_featurecounts'] - // ) - // ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) - // ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) - - } - - /* - * Create IGV session - */ - IGV ( - ch_fasta, - UCSC_BEDRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), - MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), - MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), - params.modules['ucsc_bedgraphtobigwig'], - params.modules['macs2_callpeak'], - params.modules['macs2_consensus'], - [:] - ) - - /* - * Pipeline reporting - */ - GET_SOFTWARE_VERSIONS ( - ch_software_versions.map { it }.collect(), - params.modules['get_software_versions'] - ) - - OUTPUT_DOCUMENTATION ( - ch_output_docs, - ch_output_docs_images, - [:] - ) - - /* - * MultiQC - */ - workflow_summary = Schema.params_mqc_summary(summary) - ch_workflow_summary = Channel.value(workflow_summary) - params.modules['multiqc'].publish_dir += "/$peakType" - MULTIQC ( - ch_multiqc_config, - ch_multiqc_custom_config.collect().ifEmpty([]), - GET_SOFTWARE_VERSIONS.out.yaml.collect(), - ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml'), - - FASTQC_TRIMGALORE.out.fastqc_zip.collect{it[1]}.ifEmpty([]), - FASTQC_TRIMGALORE.out.trim_log.collect{it[1]}.ifEmpty([]), - FASTQC_TRIMGALORE.out.trim_zip.collect{it[1]}.ifEmpty([]), - - MAP_BWA_MEM.out.stats.collect{it[1]}, - MAP_BWA_MEM.out.flagstat.collect{it[1]}, - MAP_BWA_MEM.out.idxstats.collect{it[1]}, - - MARK_DUPLICATES_PICARD.out.stats.collect{it[1]}.ifEmpty([]), - MARK_DUPLICATES_PICARD.out.flagstat.collect{it[1]}.ifEmpty([]), - MARK_DUPLICATES_PICARD.out.idxstats.collect{it[1]}.ifEmpty([]), - MARK_DUPLICATES_PICARD.out.metrics.collect{it[1]}.ifEmpty([]), - - BAM_CLEAN.out.stats.collect{it[1]}.ifEmpty([]), - BAM_CLEAN.out.flagstat.collect{it[1]}.ifEmpty([]), - BAM_CLEAN.out.idxstats.collect{it[1]}.ifEmpty([]), - PICARD_COLLECTMULTIPLEMETRICS.out.metrics.collect{it[1]}.ifEmpty([]), - - PRESEQ_LCEXTRAP.out.ccurve.collect{it[1]}.ifEmpty([]), - DEEPTOOLS_PLOTPROFILE.out.table.collect{it[1]}.ifEmpty([]), - DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect{it[1]}.ifEmpty([]), - PHANTOMPEAKQUALTOOLS.out.spp.collect{it[1]}.ifEmpty([]), - MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.nsc.collect{it[1]}.ifEmpty([]), - MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.rsc.collect{it[1]}.ifEmpty([]), - MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.correlation.collect{it[1]}.ifEmpty([]), - - MULTIQC_CUSTOM_PEAKS.out.count.collect{it[1]}.ifEmpty([]), - MULTIQC_CUSTOM_PEAKS.out.frip.collect{it[1]}.ifEmpty([]), - PLOT_HOMER_ANNOTATEPEAKS.out.tsv.collect().ifEmpty([]), - SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), - // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) - - params.modules['multiqc'] - ) + NFCORE_CHIPSEQ () } -//////////////////////////////////////////////////// -/* -- COMPLETION EMAIL -- */ -//////////////////////////////////////////////////// - -workflow.onComplete { - def multiqc_report = [] - Completion.email(workflow, params, summary, run_name, projectDir, multiqc_report, log) - Completion.summary(workflow, params, log) -} - -//////////////////////////////////////////////////// -/* -- THE END -- */ -//////////////////////////////////////////////////// +/* +======================================================================================== + THE END +======================================================================================== +*/ diff --git a/modules.json b/modules.json new file mode 100644 index 000000000..a11f8855c --- /dev/null +++ b/modules.json @@ -0,0 +1,14 @@ +{ + "name": "nf-core/chipseq", + "homePage": "https://github.com/nf-core/chipseq", + "repos": { + "nf-core/modules": { + "fastqc": { + "git_sha": "e937c7950af70930d1f34bb961403d9d2aa81c7d" + }, + "multiqc": { + "git_sha": "e937c7950af70930d1f34bb961403d9d2aa81c7d" + } + } + } +} diff --git a/modules/local/process/bam_filter.nf b/modules/local/bam_filter.nf similarity index 97% rename from modules/local/process/bam_filter.nf rename to modules/local/bam_filter.nf index a72f54125..0aa34fcea 100644 --- a/modules/local/process/bam_filter.nf +++ b/modules/local/bam_filter.nf @@ -1,47 +1,47 @@ -// Import generic module functions -include { initOptions; saveFiles } from './functions' - -/* - * Filter BAM file - */ -process BAM_FILTER { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:meta.id) } - - conda (params.conda ? "${baseDir}/environment.yml" : null) - - input: - tuple val(meta), path(bam), path(bai) - path bed - path bamtools_filter_se_config - path bamtools_filter_pe_config - val options - - output: - tuple val(meta), path("*.bam"), emit: bam - path "*.version.txt", emit: version - - script: - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - def filter_params = meta.single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' - def dup_params = params.keep_dups ? '' : '-F 0x0400' - def multimap_params = params.keep_multi_map ? '' : '-q 1' - def blacklist_params = params.blacklist ? "-L $bed" : '' - def config = meta.single_end ? bamtools_filter_se_config : bamtools_filter_pe_config - """ - samtools view \\ - $filter_params \\ - $dup_params \\ - $multimap_params \\ - $blacklist_params \\ - -b $bam \\ - | bamtools filter \\ - -out ${prefix}.bam \\ - -script $config - echo \$(bamtools --version 2>&1) | sed 's/^.*bamtools //; s/Part .*\$//' > bamtools.version.txt - """ -} +// Import generic module functions +include { initOptions; saveFiles } from './functions' + +/* + * Filter BAM file + */ +process BAM_FILTER { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:meta.id) } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + tuple val(meta), path(bam), path(bai) + path bed + path bamtools_filter_se_config + path bamtools_filter_pe_config + val options + + output: + tuple val(meta), path("*.bam"), emit: bam + path "*.version.txt", emit: version + + script: + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def filter_params = meta.single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' + def dup_params = params.keep_dups ? '' : '-F 0x0400' + def multimap_params = params.keep_multi_map ? '' : '-q 1' + def blacklist_params = params.blacklist ? "-L $bed" : '' + def config = meta.single_end ? bamtools_filter_se_config : bamtools_filter_pe_config + """ + samtools view \\ + $filter_params \\ + $dup_params \\ + $multimap_params \\ + $blacklist_params \\ + -b $bam \\ + | bamtools filter \\ + -out ${prefix}.bam \\ + -script $config + echo \$(bamtools --version 2>&1) | sed 's/^.*bamtools //; s/Part .*\$//' > bamtools.version.txt + """ +} diff --git a/modules/local/process/bam_remove_orphans.nf b/modules/local/bam_remove_orphans.nf similarity index 96% rename from modules/local/process/bam_remove_orphans.nf rename to modules/local/bam_remove_orphans.nf index 9d6e001ef..ea33faebe 100644 --- a/modules/local/process/bam_remove_orphans.nf +++ b/modules/local/bam_remove_orphans.nf @@ -1,36 +1,36 @@ -// Import generic module functions -include { initOptions; saveFiles } from './functions' - -/* - * Remove orphan reads from paired-end BAM file - */ -process BAM_REMOVE_ORPHANS { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:meta.id) } - - conda (params.conda ? "${baseDir}/environment.yml" : null) - - input: - tuple val(meta), path(bam) - val options - - output: - tuple val(meta), path("${prefix}.bam"), emit: bam - - script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - def ioptions = initOptions(options) - prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - if (!meta.single_end) { - """ - samtools sort -n -@ $task.cpus -o ${prefix}.name.sorted.bam -T ${prefix}.name.sorted $bam - bampe_rm_orphan.py ${prefix}.name.sorted.bam ${prefix}.bam $ioptions.args - """ - } else { - """ - ln -s $bam ${prefix}.bam - """ - } -} +// Import generic module functions +include { initOptions; saveFiles } from './functions' + +/* + * Remove orphan reads from paired-end BAM file + */ +process BAM_REMOVE_ORPHANS { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:meta.id) } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + tuple val(meta), path(bam) + val options + + output: + tuple val(meta), path("${prefix}.bam"), emit: bam + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + def ioptions = initOptions(options) + prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + if (!meta.single_end) { + """ + samtools sort -n -@ $task.cpus -o ${prefix}.name.sorted.bam -T ${prefix}.name.sorted $bam + bampe_rm_orphan.py ${prefix}.name.sorted.bam ${prefix}.bam $ioptions.args + """ + } else { + """ + ln -s $bam ${prefix}.bam + """ + } +} diff --git a/modules/local/process/bedtools_genomecov.nf b/modules/local/bedtools_genomecov.nf similarity index 97% rename from modules/local/process/bedtools_genomecov.nf rename to modules/local/bedtools_genomecov.nf index 21464e905..208bded25 100644 --- a/modules/local/process/bedtools_genomecov.nf +++ b/modules/local/bedtools_genomecov.nf @@ -1,46 +1,46 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process BEDTOOLS_GENOMECOV { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" - //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" - - conda (params.conda ? "bioconda::bedtools=2.29.2" : null) - - input: - tuple val(meta), path(bam), path(flagstat) - val options - - output: - tuple val(meta), path("*.bedGraph"), emit: bedgraph - tuple val(meta), path("*.txt"), emit: scale_factor - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - def pe = meta.single_end ? '' : '-pc' - def extend = (meta.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' - """ - SCALE_FACTOR=\$(grep 'mapped (' $flagstat | awk '{print 1000000/\$1}') - echo \$SCALE_FACTOR > ${prefix}.scale_factor.txt - - bedtools \\ - genomecov \\ - -ibam $bam \\ - -bg \\ - -scale \$SCALE_FACTOR \\ - $pe \\ - $extend \\ - | sort -T '.' -k1,1 -k2,2n > ${prefix}.bedGraph - - bedtools --version | sed -e "s/bedtools v//g" > ${software}.version.txt - """ -} +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process BEDTOOLS_GENOMECOV { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" + //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" + + conda (params.conda ? "bioconda::bedtools=2.29.2" : null) + + input: + tuple val(meta), path(bam), path(flagstat) + val options + + output: + tuple val(meta), path("*.bedGraph"), emit: bedgraph + tuple val(meta), path("*.txt"), emit: scale_factor + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def pe = meta.single_end ? '' : '-pc' + def extend = (meta.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' + """ + SCALE_FACTOR=\$(grep 'mapped (' $flagstat | awk '{print 1000000/\$1}') + echo \$SCALE_FACTOR > ${prefix}.scale_factor.txt + + bedtools \\ + genomecov \\ + -ibam $bam \\ + -bg \\ + -scale \$SCALE_FACTOR \\ + $pe \\ + $extend \\ + | sort -T '.' -k1,1 -k2,2n > ${prefix}.bedGraph + + bedtools --version | sed -e "s/bedtools v//g" > ${software}.version.txt + """ +} diff --git a/modules/local/process/deseq2_featurecounts.nf b/modules/local/deseq2_featurecounts.nf similarity index 97% rename from modules/local/process/deseq2_featurecounts.nf rename to modules/local/deseq2_featurecounts.nf index 4586ee7e1..7673a4295 100644 --- a/modules/local/process/deseq2_featurecounts.nf +++ b/modules/local/deseq2_featurecounts.nf @@ -1,55 +1,55 @@ -conda (params.conda ? "${baseDir}/environment.yml" : null) - -// /* -// * STEP 7.4: Differential analysis with DESeq2 -// */ -// process CONSENSUS_PEAKS_DESEQ2 { -// tag "${antibody}" -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (filename.endsWith('.igv.txt')) null -// else filename -// } -// -// when: -// params.macs_gsize && replicatesExist && multipleGroups && !params.skip_consensus_peaks && !params.skip_diff_analysis -// -// input: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(counts) from ch_macs_consensus_counts -// path deseq2_pca_header from ch_deseq2_pca_header -// path deseq2_clustering_header from ch_deseq2_clustering_header -// -// output: -// path '*.tsv' into ch_macs_consensus_deseq_mqc -// path '*igv.txt' into ch_macs_consensus_deseq_comp_igv -// path '*.{RData,results.txt,pdf,log}' -// path 'sizeFactors' -// path '*vs*/*.{pdf,txt}' -// path '*vs*/*.bed' -// -// script: -// prefix = "${antibody}.consensus_peaks" -// bam_ext = params.single_end ? '.mLb.clN.sorted.bam' : '.mLb.clN.bam' -// vst = params.deseq2_vst ? '--vst TRUE' : '' -// """ -// featurecounts_deseq2.r \\ -// --featurecount_file $counts \\ -// --bam_suffix '$bam_ext' \\ -// --outdir ./ \\ -// --outprefix $prefix \\ -// --outsuffix '' \\ -// --cores $task.cpus \\ -// $vst -// -// sed 's/deseq2_pca/deseq2_pca_${task.index}/g' <$deseq2_pca_header >tmp.txt -// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt -// cat tmp.txt ${prefix}.pca.vals.txt > ${prefix}.pca.vals_mqc.tsv -// -// sed 's/deseq2_clustering/deseq2_clustering_${task.index}/g' <$deseq2_clustering_header >tmp.txt -// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt -// cat tmp.txt ${prefix}.sample.dists.txt > ${prefix}.sample.dists_mqc.tsv -// -// find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt -// """ -// } +conda (params.conda ? "${baseDir}/environment.yml" : null) + +// /* +// * STEP 7.4: Differential analysis with DESeq2 +// */ +// process CONSENSUS_PEAKS_DESEQ2 { +// tag "${antibody}" +// label 'process_medium' +// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2", mode: params.publish_dir_mode, +// saveAs: { filename -> +// if (filename.endsWith('.igv.txt')) null +// else filename +// } +// +// when: +// params.macs_gsize && replicatesExist && multipleGroups && !params.skip_consensus_peaks && !params.skip_diff_analysis +// +// input: +// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(counts) from ch_macs_consensus_counts +// path deseq2_pca_header from ch_deseq2_pca_header +// path deseq2_clustering_header from ch_deseq2_clustering_header +// +// output: +// path '*.tsv' into ch_macs_consensus_deseq_mqc +// path '*igv.txt' into ch_macs_consensus_deseq_comp_igv +// path '*.{RData,results.txt,pdf,log}' +// path 'sizeFactors' +// path '*vs*/*.{pdf,txt}' +// path '*vs*/*.bed' +// +// script: +// prefix = "${antibody}.consensus_peaks" +// bam_ext = params.single_end ? '.mLb.clN.sorted.bam' : '.mLb.clN.bam' +// vst = params.deseq2_vst ? '--vst TRUE' : '' +// """ +// featurecounts_deseq2.r \\ +// --featurecount_file $counts \\ +// --bam_suffix '$bam_ext' \\ +// --outdir ./ \\ +// --outprefix $prefix \\ +// --outsuffix '' \\ +// --cores $task.cpus \\ +// $vst +// +// sed 's/deseq2_pca/deseq2_pca_${task.index}/g' <$deseq2_pca_header >tmp.txt +// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt +// cat tmp.txt ${prefix}.pca.vals.txt > ${prefix}.pca.vals_mqc.tsv +// +// sed 's/deseq2_clustering/deseq2_clustering_${task.index}/g' <$deseq2_clustering_header >tmp.txt +// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt +// cat tmp.txt ${prefix}.sample.dists.txt > ${prefix}.sample.dists_mqc.tsv +// +// find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt +// """ +// } diff --git a/modules/local/process/frip_score.nf b/modules/local/frip_score.nf similarity index 97% rename from modules/local/process/frip_score.nf rename to modules/local/frip_score.nf index 1fd0a7b41..cb19cbfc5 100644 --- a/modules/local/process/frip_score.nf +++ b/modules/local/frip_score.nf @@ -1,28 +1,28 @@ -// Import generic module functions -include { initOptions; saveFiles } from './functions' - -process FRIP_SCORE { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:meta.id) } - - conda (params.conda ? "${baseDir}/environment.yml" : null) - - input: - tuple val(meta), path(bam), path(peak) - val options - - output: - tuple val(meta), path("*.txt"), emit: txt - - script: - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - """ - READS_IN_PEAKS=\$(intersectBed -a $bam -b $peak $ioptions.args | awk -F '\t' '{sum += \$NF} END {print sum}') - samtools flagstat $bam > ${bam}.flagstat - grep 'mapped (' ${bam}.flagstat | awk -v a="\$READS_IN_PEAKS" -v OFS='\t' '{print "${prefix}", a/\$1}' > ${prefix}.FRiP.txt - """ -} +// Import generic module functions +include { initOptions; saveFiles } from './functions' + +process FRIP_SCORE { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:meta.id) } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + tuple val(meta), path(bam), path(peak) + val options + + output: + tuple val(meta), path("*.txt"), emit: txt + + script: + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + """ + READS_IN_PEAKS=\$(intersectBed -a $bam -b $peak $ioptions.args | awk -F '\t' '{sum += \$NF} END {print sum}') + samtools flagstat $bam > ${bam}.flagstat + grep 'mapped (' ${bam}.flagstat | awk -v a="\$READS_IN_PEAKS" -v OFS='\t' '{print "${prefix}", a/\$1}' > ${prefix}.FRiP.txt + """ +} diff --git a/modules/local/functions.nf b/modules/local/functions.nf new file mode 100644 index 000000000..da9da093d --- /dev/null +++ b/modules/local/functions.nf @@ -0,0 +1,68 @@ +// +// Utility functions used in nf-core DSL2 module files +// + +// +// Extract name of software tool from process name using $task.process +// +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +// +// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules +// +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.args3 = args.args3 ?: '' + options.publish_by_meta = args.publish_by_meta ?: [] + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files + options.suffix = args.suffix ?: '' + return options +} + +// +// Tidy up and join elements of a list to return a path string +// +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +// +// Function to save/publish module results +// +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_meta) { + def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta + for (key in key_list) { + if (args.meta && key instanceof String) { + def path = key + if (args.meta.containsKey(key)) { + path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] + } + path = path instanceof String ? path : '' + path_list.add(path) + } + } + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else if (ioptions.publish_files == null) { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/local/process/get_chrom_sizes.nf b/modules/local/get_chrom_sizes.nf similarity index 96% rename from modules/local/process/get_chrom_sizes.nf rename to modules/local/get_chrom_sizes.nf index e929db2d4..11ab9ff7f 100644 --- a/modules/local/process/get_chrom_sizes.nf +++ b/modules/local/get_chrom_sizes.nf @@ -1,34 +1,34 @@ -// Import generic module functions -include { saveFiles } from './functions' - -/* - * Get chromosome sizes from a fasta file - */ -process GET_CHROM_SIZES { - tag "$fasta" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"genome", publish_id:'') } - - container "quay.io/biocontainers/samtools:1.10--h9402c20_2" - //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - - conda (params.conda ? "bioconda::samtools=1.10" : null) - - input: - path fasta - val options - - output: - path '*.sizes', emit: sizes - path '*.fai', emit: fai - path "*.version.txt", emit: version - - script: - def software = 'samtools' - """ - samtools faidx $fasta - cut -f 1,2 ${fasta}.fai > ${fasta}.sizes - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt - """ -} +// Import generic module functions +include { saveFiles } from './functions' + +/* + * Get chromosome sizes from a fasta file + */ +process GET_CHROM_SIZES { + tag "$fasta" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"genome", publish_id:'') } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "bioconda::samtools=1.10" : null) + + input: + path fasta + val options + + output: + path '*.sizes', emit: sizes + path '*.fai', emit: fai + path "*.version.txt", emit: version + + script: + def software = 'samtools' + """ + samtools faidx $fasta + cut -f 1,2 ${fasta}.fai > ${fasta}.sizes + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/local/get_software_versions.nf b/modules/local/get_software_versions.nf new file mode 100644 index 000000000..3e9926b85 --- /dev/null +++ b/modules/local/get_software_versions.nf @@ -0,0 +1,33 @@ +// Import generic module functions +include { saveFiles } from './functions' + +params.options = [:] + +process GET_SOFTWARE_VERSIONS { + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'pipeline_info', meta:[:], publish_by_meta:[]) } + + conda (params.enable_conda ? "conda-forge::python=3.8.3" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://depot.galaxyproject.org/singularity/python:3.8.3" + } else { + container "quay.io/biocontainers/python:3.8.3" + } + + cache false + + input: + path versions + + output: + path "software_versions.tsv" , emit: tsv + path 'software_versions_mqc.yaml', emit: yaml + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + """ + echo $workflow.manifest.version > pipeline.version.txt + echo $workflow.nextflow.version > nextflow.version.txt + scrape_software_versions.py &> software_versions_mqc.yaml + """ +} diff --git a/modules/local/process/gtf2bed.nf b/modules/local/gtf2bed.nf similarity index 96% rename from modules/local/process/gtf2bed.nf rename to modules/local/gtf2bed.nf index 4258b2379..8026a0ec0 100644 --- a/modules/local/process/gtf2bed.nf +++ b/modules/local/gtf2bed.nf @@ -1,30 +1,30 @@ -// Import generic module functions -include { saveFiles } from './functions' - -/* - * Convert GTF file to BED format - */ -process GTF2BED { - tag "$gtf" - label 'process_low' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"genome", publish_id:'') } - - container "quay.io/biocontainers/perl:5.26.2" - //container "https://depot.galaxyproject.org/singularity/perl:5.26.2" - - conda (params.conda ? "conda-forge::perl=5.26.2" : null) - - input: - path gtf - val options - - output: - path '*.bed' - - script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - """ - gtf2bed $gtf > ${gtf.baseName}.bed - """ -} +// Import generic module functions +include { saveFiles } from './functions' + +/* + * Convert GTF file to BED format + */ +process GTF2BED { + tag "$gtf" + label 'process_low' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"genome", publish_id:'') } + + container "quay.io/biocontainers/perl:5.26.2" + //container "https://depot.galaxyproject.org/singularity/perl:5.26.2" + + conda (params.conda ? "conda-forge::perl=5.26.2" : null) + + input: + path gtf + val options + + output: + path '*.bed' + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + """ + gtf2bed $gtf > ${gtf.baseName}.bed + """ +} diff --git a/modules/local/process/igv.nf b/modules/local/igv.nf similarity index 97% rename from modules/local/process/igv.nf rename to modules/local/igv.nf index c13aa3503..c131e044a 100644 --- a/modules/local/process/igv.nf +++ b/modules/local/igv.nf @@ -1,39 +1,39 @@ -// Import generic module functions -include { saveFiles } from './functions' - -/* - * Create IGV session file - */ -process IGV { - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:'') } - - conda (params.conda ? "${baseDir}/environment.yml" : null) - - input: - path fasta - path ("${bigwig_options.publish_dir}/*") - path ("${peak_options.publish_dir}/*") - path ("${consensus_options.publish_dir}/*") - val bigwig_options - val peak_options - val consensus_options - // path differential_peaks from ch_macs_consensus_deseq_comp_igv.collect().ifEmpty([]) - val options - - output: - path "*files.txt", emit: txt - path "*.xml", emit: xml - - script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ - """ - find * -type l -name "*.bigWig" -exec echo -e ""{}"\\t0,0,178" \\; > bigwig.igv.txt - find * -type l -name "*Peak" -exec echo -e ""{}"\\t0,0,178" \\; > peaks.igv.txt - - cat *.txt > igv_files.txt - igv_files_to_session.py igv_session.xml igv_files.txt ../../genome/${fasta.getName()} --path_prefix '../../' - """ -} -// find * -type f -name "${prefix}.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/"{}"\\t0,0,0" \\; > ${prefix}.bed.igv.txt -// find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt +// Import generic module functions +include { saveFiles } from './functions' + +/* + * Create IGV session file + */ +process IGV { + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:'') } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + path fasta + path ("${bigwig_options.publish_dir}/*") + path ("${peak_options.publish_dir}/*") + path ("${consensus_options.publish_dir}/*") + val bigwig_options + val peak_options + val consensus_options + // path differential_peaks from ch_macs_consensus_deseq_comp_igv.collect().ifEmpty([]) + val options + + output: + path "*files.txt", emit: txt + path "*.xml", emit: xml + + script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ + """ + find * -type l -name "*.bigWig" -exec echo -e ""{}"\\t0,0,178" \\; > bigwig.igv.txt + find * -type l -name "*Peak" -exec echo -e ""{}"\\t0,0,178" \\; > peaks.igv.txt + + cat *.txt > igv_files.txt + igv_files_to_session.py igv_session.xml igv_files.txt ../../genome/${fasta.getName()} --path_prefix '../../' + """ +} +// find * -type f -name "${prefix}.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/"{}"\\t0,0,0" \\; > ${prefix}.bed.igv.txt +// find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt diff --git a/modules/local/process/macs2_consensus.nf b/modules/local/macs2_consensus.nf similarity index 97% rename from modules/local/process/macs2_consensus.nf rename to modules/local/macs2_consensus.nf index b3ba35ff4..727c25b63 100644 --- a/modules/local/process/macs2_consensus.nf +++ b/modules/local/macs2_consensus.nf @@ -1,55 +1,55 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -/* - * Consensus peaks across samples, create boolean filtering file, SAF file for featureCounts - */ -process MACS2_CONSENSUS { - tag "$meta.id" - label 'process_long' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - conda (params.conda ? "${baseDir}/environment.yml" : null) - - input: - tuple val(meta), path(peaks) - val options - - output: - tuple val(meta), path("*.bed"), emit: bed - tuple val(meta), path("*.saf"), emit: saf - tuple val(meta), path("*.pdf"), emit: pdf - tuple val(meta), path("*.boolean.txt"), emit: boolean_txt - tuple val(meta), path("*.intersect.txt"), emit: intersect_txt - - script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - if (meta.multiple_groups || meta.replicates_exist) { - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}.consensus_peaks" : "${meta.id}.consensus_peaks" - def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' - def mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') - def collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') - def expandparam = params.narrow_peak ? '--is_narrow_peak' : '' - """ - sort -T '.' -k1,1 -k2,2n ${peaks.collect{it.toString()}.sort().join(' ')} \\ - | mergeBed -c $mergecols -o $collapsecols > ${prefix}.txt - - macs2_merged_expand.py \\ - ${prefix}.txt \\ - ${peaks.collect{it.toString()}.sort().join(',').replaceAll("_peaks.${peak_type}","")} \\ - ${prefix}.boolean.txt \\ - --min_replicates $params.min_reps_consensus \\ - $expandparam - - awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$1, \$2, \$3, \$4, "0", "+" }' ${prefix}.boolean.txt > ${prefix}.bed - - echo -e "GeneID\tChr\tStart\tEnd\tStrand" > ${prefix}.saf - awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$4, \$1, \$2, \$3, "+" }' ${prefix}.boolean.txt >> ${prefix}.saf - - plot_peak_intersect.r -i ${prefix}.boolean.intersect.txt -o ${prefix}.boolean.intersect.plot.pdf - """ - } -} +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +/* + * Consensus peaks across samples, create boolean filtering file, SAF file for featureCounts + */ +process MACS2_CONSENSUS { + tag "$meta.id" + label 'process_long' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + tuple val(meta), path(peaks) + val options + + output: + tuple val(meta), path("*.bed"), emit: bed + tuple val(meta), path("*.saf"), emit: saf + tuple val(meta), path("*.pdf"), emit: pdf + tuple val(meta), path("*.boolean.txt"), emit: boolean_txt + tuple val(meta), path("*.intersect.txt"), emit: intersect_txt + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + if (meta.multiple_groups || meta.replicates_exist) { + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}.consensus_peaks" : "${meta.id}.consensus_peaks" + def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' + def mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') + def collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') + def expandparam = params.narrow_peak ? '--is_narrow_peak' : '' + """ + sort -T '.' -k1,1 -k2,2n ${peaks.collect{it.toString()}.sort().join(' ')} \\ + | mergeBed -c $mergecols -o $collapsecols > ${prefix}.txt + + macs2_merged_expand.py \\ + ${prefix}.txt \\ + ${peaks.collect{it.toString()}.sort().join(',').replaceAll("_peaks.${peak_type}","")} \\ + ${prefix}.boolean.txt \\ + --min_replicates $params.min_reps_consensus \\ + $expandparam + + awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$1, \$2, \$3, \$4, "0", "+" }' ${prefix}.boolean.txt > ${prefix}.bed + + echo -e "GeneID\tChr\tStart\tEnd\tStrand" > ${prefix}.saf + awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$4, \$1, \$2, \$3, "+" }' ${prefix}.boolean.txt >> ${prefix}.saf + + plot_peak_intersect.r -i ${prefix}.boolean.intersect.txt -o ${prefix}.boolean.intersect.plot.pdf + """ + } +} diff --git a/modules/local/process/make_genome_filter.nf b/modules/local/make_genome_filter.nf similarity index 96% rename from modules/local/process/make_genome_filter.nf rename to modules/local/make_genome_filter.nf index 042fcdc49..e008a4455 100644 --- a/modules/local/process/make_genome_filter.nf +++ b/modules/local/make_genome_filter.nf @@ -1,41 +1,41 @@ -// Import generic module functions -include { saveFiles } from './functions' - -/* - * Prepare genome intervals for filtering by removing regions in blacklist file - */ -process MAKE_GENOME_FILTER { - tag "$sizes" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"genome", publish_id:'') } - - container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" - //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" - - conda (params.conda ? "bioconda::bedtools=2.29.2" : null) - - input: - path sizes - path blacklist - val options - - output: - path '*.bed', emit: bed - path "*.version.txt", emit: version - - script: - def software = 'bedtools' - def file_out = "${sizes.simpleName}.include_regions.bed" - if (params.blacklist) { - """ - sortBed -i $blacklist -g $sizes | complementBed -i stdin -g $sizes > $file_out - bedtools --version | sed -e "s/bedtools v//g" > ${software}.version.txt - """ - } else { - """ - awk '{print \$1, '0' , \$2}' OFS='\t' $sizes > $file_out - bedtools --version | sed -e "s/bedtools v//g" > ${software}.version.txt - """ - } -} +// Import generic module functions +include { saveFiles } from './functions' + +/* + * Prepare genome intervals for filtering by removing regions in blacklist file + */ +process MAKE_GENOME_FILTER { + tag "$sizes" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"genome", publish_id:'') } + + container "quay.io/biocontainers/bedtools:2.29.2--hc088bd4_0" + //container "https://depot.galaxyproject.org/singularity/bedtools:2.29.2--hc088bd4_0" + + conda (params.conda ? "bioconda::bedtools=2.29.2" : null) + + input: + path sizes + path blacklist + val options + + output: + path '*.bed', emit: bed + path "*.version.txt", emit: version + + script: + def software = 'bedtools' + def file_out = "${sizes.simpleName}.include_regions.bed" + if (params.blacklist) { + """ + sortBed -i $blacklist -g $sizes | complementBed -i stdin -g $sizes > $file_out + bedtools --version | sed -e "s/bedtools v//g" > ${software}.version.txt + """ + } else { + """ + awk '{print \$1, '0' , \$2}' OFS='\t' $sizes > $file_out + bedtools --version | sed -e "s/bedtools v//g" > ${software}.version.txt + """ + } +} diff --git a/modules/local/process/multiqc.nf b/modules/local/multiqc.nf similarity index 83% rename from modules/local/process/multiqc.nf rename to modules/local/multiqc.nf index 3a9865f8e..26ea1adae 100644 --- a/modules/local/process/multiqc.nf +++ b/modules/local/multiqc.nf @@ -3,10 +3,10 @@ include { initOptions; saveFiles; getSoftwareName } from './functions' // Has the run name been specified by the user? // this has the bonus effect of catching both -name and --name -custom_runName = params.name -if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { - custom_runName = workflow.runName -} +// custom_runName = params.name // TODO remove +// if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { +// custom_runName = workflow.runName +// } process MULTIQC { label 'process_medium' @@ -67,10 +67,10 @@ process MULTIQC { script: def software = getSoftwareName(task.process) def ioptions = initOptions(options) - def rtitle = custom_runName ? "--title \"$custom_runName\"" : '' - def rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' + // def rtitle = custom_runName ? "--title \"$custom_runName\"" : '' + // def rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' def custom_config = params.multiqc_config ? "--config $mqc_custom_config" : '' """ - multiqc -f $ioptions.args $rtitle $rfilename $custom_config . + multiqc -f $ioptions.args $custom_config . """ } diff --git a/modules/local/process/multiqc_custom_peaks.nf b/modules/local/multiqc_custom_peaks.nf similarity index 97% rename from modules/local/process/multiqc_custom_peaks.nf rename to modules/local/multiqc_custom_peaks.nf index f98ee9bae..33abfd908 100644 --- a/modules/local/process/multiqc_custom_peaks.nf +++ b/modules/local/multiqc_custom_peaks.nf @@ -1,30 +1,30 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process MULTIQC_CUSTOM_PEAKS { - tag "$meta.id" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - conda (params.conda ? "${baseDir}/environment.yml" : null) - - input: - tuple val(meta), path(peak), path(frip) - path peak_count_header - path frip_score_header - val options - - output: - tuple val(meta), path("*.peak_count_mqc.tsv"), emit: count - tuple val(meta), path("*.FRiP_mqc.tsv"), emit: frip - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - """ - cat $peak | wc -l | awk -v OFS='\t' '{ print "${prefix}", \$1 }' | cat $peak_count_header - > ${prefix}.peak_count_mqc.tsv - cat $frip_score_header $frip > ${prefix}.FRiP_mqc.tsv - """ -} +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process MULTIQC_CUSTOM_PEAKS { + tag "$meta.id" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + tuple val(meta), path(peak), path(frip) + path peak_count_header + path frip_score_header + val options + + output: + tuple val(meta), path("*.peak_count_mqc.tsv"), emit: count + tuple val(meta), path("*.FRiP_mqc.tsv"), emit: frip + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + """ + cat $peak | wc -l | awk -v OFS='\t' '{ print "${prefix}", \$1 }' | cat $peak_count_header - > ${prefix}.peak_count_mqc.tsv + cat $frip_score_header $frip > ${prefix}.FRiP_mqc.tsv + """ +} diff --git a/modules/local/process/multiqc_custom_phantompeakqualtools.nf b/modules/local/multiqc_custom_phantompeakqualtools.nf similarity index 97% rename from modules/local/process/multiqc_custom_phantompeakqualtools.nf rename to modules/local/multiqc_custom_phantompeakqualtools.nf index a49fbf17c..f7ef7d049 100644 --- a/modules/local/process/multiqc_custom_phantompeakqualtools.nf +++ b/modules/local/multiqc_custom_phantompeakqualtools.nf @@ -1,35 +1,35 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { - tag "$meta.id" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - conda (params.conda ? "${baseDir}/environment.yml" : null) - - input: - tuple val(meta), path(spp), path(rdata) - path nsc_header - path rsc_header - path correlation_header - val options - - output: - tuple val(meta), path("*.spp_nsc_mqc.tsv"), emit: nsc - tuple val(meta), path("*.spp_rsc_mqc.tsv"), emit: rsc - tuple val(meta), path("*.spp_correlation_mqc.tsv"), emit: correlation - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - """ - cp $correlation_header ${prefix}.spp_correlation_mqc.tsv - Rscript -e "load('$rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}.spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" - - awk -v OFS='\t' '{print "${meta.id}", \$9}' $spp | cat $nsc_header - > ${prefix}.spp_nsc_mqc.tsv - awk -v OFS='\t' '{print "${meta.id}", \$10}' $spp | cat $rsc_header - > ${prefix}.spp_rsc_mqc.tsv - """ -} +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { + tag "$meta.id" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + tuple val(meta), path(spp), path(rdata) + path nsc_header + path rsc_header + path correlation_header + val options + + output: + tuple val(meta), path("*.spp_nsc_mqc.tsv"), emit: nsc + tuple val(meta), path("*.spp_rsc_mqc.tsv"), emit: rsc + tuple val(meta), path("*.spp_correlation_mqc.tsv"), emit: correlation + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + """ + cp $correlation_header ${prefix}.spp_correlation_mqc.tsv + Rscript -e "load('$rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}.spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" + + awk -v OFS='\t' '{print "${meta.id}", \$9}' $spp | cat $nsc_header - > ${prefix}.spp_nsc_mqc.tsv + awk -v OFS='\t' '{print "${meta.id}", \$10}' $spp | cat $rsc_header - > ${prefix}.spp_rsc_mqc.tsv + """ +} diff --git a/modules/local/process/output_documentation.nf b/modules/local/output_documentation.nf similarity index 100% rename from modules/local/process/output_documentation.nf rename to modules/local/output_documentation.nf diff --git a/modules/local/process/plot_homer_annotatepeaks.nf b/modules/local/plot_homer_annotatepeaks.nf similarity index 96% rename from modules/local/process/plot_homer_annotatepeaks.nf rename to modules/local/plot_homer_annotatepeaks.nf index c474cfc66..c503c7d24 100644 --- a/modules/local/process/plot_homer_annotatepeaks.nf +++ b/modules/local/plot_homer_annotatepeaks.nf @@ -1,36 +1,36 @@ -// Import generic module functions -include { initOptions; saveFiles } from './functions' - -/* - * Aggregated QC plots for peak-to-gene annotation - */ -process PLOT_HOMER_ANNOTATEPEAKS { - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:'') } - - conda (params.conda ? "${baseDir}/environment.yml" : null) - - input: - path annos - path mqc_header - val suffix - val options - - output: - path '*.txt', emit: txt - path '*.pdf', emit: pdf - path '*.tsv', emit: tsv - - script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - def ioptions = initOptions(options) - """ - plot_homer_annotatepeaks.r \\ - -i ${annos.join(',')} \\ - -s ${annos.join(',').replaceAll("${suffix}","")} \\ - $ioptions.args - - find ./ -type f -name "*.txt" -exec cat {} \\; | cat $mqc_header - > annotatepeaks.summary_mqc.tsv - """ -} +// Import generic module functions +include { initOptions; saveFiles } from './functions' + +/* + * Aggregated QC plots for peak-to-gene annotation + */ +process PLOT_HOMER_ANNOTATEPEAKS { + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:'') } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + path annos + path mqc_header + val suffix + val options + + output: + path '*.txt', emit: txt + path '*.pdf', emit: pdf + path '*.tsv', emit: tsv + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + def ioptions = initOptions(options) + """ + plot_homer_annotatepeaks.r \\ + -i ${annos.join(',')} \\ + -s ${annos.join(',').replaceAll("${suffix}","")} \\ + $ioptions.args + + find ./ -type f -name "*.txt" -exec cat {} \\; | cat $mqc_header - > annotatepeaks.summary_mqc.tsv + """ +} diff --git a/modules/local/process/plot_macs2_qc.nf b/modules/local/plot_macs2_qc.nf similarity index 96% rename from modules/local/process/plot_macs2_qc.nf rename to modules/local/plot_macs2_qc.nf index ee3065f03..8d2cce690 100644 --- a/modules/local/process/plot_macs2_qc.nf +++ b/modules/local/plot_macs2_qc.nf @@ -1,32 +1,32 @@ -// Import generic module functions -include { initOptions; saveFiles } from './functions' - -/* - * Aggregated QC plots for peaks - */ -process PLOT_MACS2_QC { - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:'') } - - conda (params.conda ? "${baseDir}/environment.yml" : null) - - input: - path peaks - val options - - output: - path '*.txt', emit: txt - path '*.pdf', emit: pdf - - script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - def ioptions = initOptions(options) - def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' - """ - plot_macs2_qc.r \\ - -i ${peaks.join(',')} \\ - -s ${peaks.join(',').replaceAll("_peaks.${peak_type}","")} \\ - $ioptions.args - """ -} +// Import generic module functions +include { initOptions; saveFiles } from './functions' + +/* + * Aggregated QC plots for peaks + */ +process PLOT_MACS2_QC { + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:task.process.toLowerCase(), publish_id:'') } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + path peaks + val options + + output: + path '*.txt', emit: txt + path '*.pdf', emit: pdf + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + def ioptions = initOptions(options) + def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' + """ + plot_macs2_qc.r \\ + -i ${peaks.join(',')} \\ + -s ${peaks.join(',').replaceAll("_peaks.${peak_type}","")} \\ + $ioptions.args + """ +} diff --git a/modules/local/process/functions.nf b/modules/local/process/functions.nf deleted file mode 100644 index 6f72fdc10..000000000 --- a/modules/local/process/functions.nf +++ /dev/null @@ -1,59 +0,0 @@ -/* - * ----------------------------------------------------- - * Utility functions used in nf-core DSL2 module files - * ----------------------------------------------------- - */ - -/* - * Extract name of software tool from process name using $task.process - */ -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -/* - * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules - */ -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ?: '' - options.publish_files = (args.publish_files instanceof Map)? args.publish_files : null - options.suffix = args.suffix ?: '' - return options -} - -/* - * Tidy up and join elements of a list to return a path string - */ -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -/* - * Function to save/publish module results - */ -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_id) { - path_list.add(args.publish_id) - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} diff --git a/modules/local/process/get_software_versions.nf b/modules/local/process/get_software_versions.nf deleted file mode 100644 index db1cab64a..000000000 --- a/modules/local/process/get_software_versions.nf +++ /dev/null @@ -1,26 +0,0 @@ -// Import generic module functions -include { saveFiles } from './functions' - -/* - * Parse software version numbers - */ -process GET_SOFTWARE_VERSIONS { - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"pipeline_info", publish_id:'') } - - input: - path versions - val options - - output: - path "software_versions.csv", emit: csv - path 'software_versions_mqc.yaml', emit: yaml - - script: - """ - echo $workflow.manifest.version > pipeline.version.txt - echo $workflow.nextflow.version > nextflow.version.txt - scrape_software_versions.py &> software_versions_mqc.yaml - """ -} diff --git a/modules/local/samplesheet_check.nf b/modules/local/samplesheet_check.nf new file mode 100644 index 000000000..efa94f7f5 --- /dev/null +++ b/modules/local/samplesheet_check.nf @@ -0,0 +1,26 @@ +// Import generic module functions +include { saveFiles } from './functions' + +/* + * Reformat design file, check validitiy and create IP vs control mappings + */ +process SAMPLESHEET_CHECK { + tag "$samplesheet" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"pipeline_info", publish_id:'') } + + conda (params.conda ? "${baseDir}/environment.yml" : null) + + input: + path samplesheet + val options + + output: + path '*.csv' + + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + """ + check_samplesheet.py $samplesheet samplesheet.valid.csv + """ +} diff --git a/modules/local/subworkflow/input_check.nf b/modules/local/subworkflow/input_check.nf deleted file mode 100644 index 88c6cac11..000000000 --- a/modules/local/subworkflow/input_check.nf +++ /dev/null @@ -1,22 +0,0 @@ -/* - * Check input samplesheet and get read channels - */ - -include { SAMPLESHEET_CHECK; - get_samplesheet_paths } from '../process/samplesheet_check' - -workflow INPUT_CHECK { - take: - ch_input // file: /path/to/samplesheet.csv - seq_center // string: sequencing center for read group - samplesheet_check_options // map: options for check_samplesheet module - - main: - SAMPLESHEET_CHECK (ch_input, samplesheet_check_options) - .splitCsv(header:true, sep:',') - .map { get_samplesheet_paths(it, seq_center) } - .set { ch_reads } - - emit: - reads = ch_reads // channel: [ val(meta), [ reads ] ] -} diff --git a/modules/nf-core/software/bwa/mem/functions.nf b/modules/nf-core/modules/bwa/index/functions.nf similarity index 97% rename from modules/nf-core/software/bwa/mem/functions.nf rename to modules/nf-core/modules/bwa/index/functions.nf index 75553cdf5..5bafdbe17 100644 --- a/modules/nf-core/software/bwa/mem/functions.nf +++ b/modules/nf-core/modules/bwa/index/functions.nf @@ -1,59 +1,59 @@ -/* - * ----------------------------------------------------- - * Utility functions used in nf-core DSL2 module files - * ----------------------------------------------------- - */ - -/* - * Extract name of software tool from process name using $task.process - */ -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -/* - * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules - */ -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files ?: null - options.suffix = args.suffix ?: '' - return options -} - -/* - * Tidy up and join elements of a list to return a path string - */ -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -/* - * Function to save/publish module results - */ -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_id) { - path_list.add(args.publish_id) - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/bwa/index/main.nf b/modules/nf-core/modules/bwa/index/main.nf similarity index 100% rename from modules/nf-core/software/bwa/index/main.nf rename to modules/nf-core/modules/bwa/index/main.nf diff --git a/modules/nf-core/software/bwa/index/meta.yml b/modules/nf-core/modules/bwa/index/meta.yml similarity index 100% rename from modules/nf-core/software/bwa/index/meta.yml rename to modules/nf-core/modules/bwa/index/meta.yml diff --git a/modules/nf-core/software/fastqc/functions.nf b/modules/nf-core/modules/bwa/mem/functions.nf similarity index 97% rename from modules/nf-core/software/fastqc/functions.nf rename to modules/nf-core/modules/bwa/mem/functions.nf index 75553cdf5..5bafdbe17 100644 --- a/modules/nf-core/software/fastqc/functions.nf +++ b/modules/nf-core/modules/bwa/mem/functions.nf @@ -1,59 +1,59 @@ -/* - * ----------------------------------------------------- - * Utility functions used in nf-core DSL2 module files - * ----------------------------------------------------- - */ - -/* - * Extract name of software tool from process name using $task.process - */ -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -/* - * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules - */ -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files ?: null - options.suffix = args.suffix ?: '' - return options -} - -/* - * Tidy up and join elements of a list to return a path string - */ -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -/* - * Function to save/publish module results - */ -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_id) { - path_list.add(args.publish_id) - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/bwa/mem/main.nf b/modules/nf-core/modules/bwa/mem/main.nf similarity index 97% rename from modules/nf-core/software/bwa/mem/main.nf rename to modules/nf-core/modules/bwa/mem/main.nf index 127bc7003..f94d2129b 100644 --- a/modules/nf-core/software/bwa/mem/main.nf +++ b/modules/nf-core/modules/bwa/mem/main.nf @@ -1,42 +1,42 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process BWA_MEM { - tag "$meta.id" - label 'process_high' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" - //container "https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" - - conda (params.conda ? "bioconda::bwa=0.7.17 bioconda::samtools=1.10" : null) - - input: - tuple val(meta), path(reads) - path index - path fasta - val options - - output: - tuple val(meta), path("*.bam"), emit: bam - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - def rg = meta.read_group ? "-R ${meta.read_group}" : "" - """ - bwa mem \\ - $ioptions.args \\ - $rg \\ - -t $task.cpus \\ - $fasta \\ - $reads \\ - | samtools view $ioptions.args2 -@ $task.cpus -bS -o ${prefix}.bam - - - echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${software}.version.txt - """ -} +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process BWA_MEM { + tag "$meta.id" + label 'process_high' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" + //container "https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:eabfac3657eda5818bae4090db989e3d41b01542-0" + + conda (params.conda ? "bioconda::bwa=0.7.17 bioconda::samtools=1.10" : null) + + input: + tuple val(meta), path(reads) + path index + path fasta + val options + + output: + tuple val(meta), path("*.bam"), emit: bam + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def rg = meta.read_group ? "-R ${meta.read_group}" : "" + """ + bwa mem \\ + $ioptions.args \\ + $rg \\ + -t $task.cpus \\ + $fasta \\ + $reads \\ + | samtools view $ioptions.args2 -@ $task.cpus -bS -o ${prefix}.bam - + + echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/bwa/mem/meta.yml b/modules/nf-core/modules/bwa/mem/meta.yml similarity index 100% rename from modules/nf-core/software/bwa/mem/meta.yml rename to modules/nf-core/modules/bwa/mem/meta.yml diff --git a/modules/nf-core/software/bwa/index/functions.nf b/modules/nf-core/modules/fastqc/functions.nf similarity index 97% rename from modules/nf-core/software/bwa/index/functions.nf rename to modules/nf-core/modules/fastqc/functions.nf index 75553cdf5..5bafdbe17 100644 --- a/modules/nf-core/software/bwa/index/functions.nf +++ b/modules/nf-core/modules/fastqc/functions.nf @@ -1,59 +1,59 @@ -/* - * ----------------------------------------------------- - * Utility functions used in nf-core DSL2 module files - * ----------------------------------------------------- - */ - -/* - * Extract name of software tool from process name using $task.process - */ -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -/* - * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules - */ -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files ?: null - options.suffix = args.suffix ?: '' - return options -} - -/* - * Tidy up and join elements of a list to return a path string - */ -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -/* - * Function to save/publish module results - */ -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_id) { - path_list.add(args.publish_id) - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/fastqc/main.nf b/modules/nf-core/modules/fastqc/main.nf similarity index 100% rename from modules/nf-core/software/fastqc/main.nf rename to modules/nf-core/modules/fastqc/main.nf diff --git a/modules/nf-core/software/fastqc/meta.yml b/modules/nf-core/modules/fastqc/meta.yml similarity index 100% rename from modules/nf-core/software/fastqc/meta.yml rename to modules/nf-core/modules/fastqc/meta.yml diff --git a/modules/nf-core/modules/multiqc/functions.nf b/modules/nf-core/modules/multiqc/functions.nf new file mode 100644 index 000000000..da9da093d --- /dev/null +++ b/modules/nf-core/modules/multiqc/functions.nf @@ -0,0 +1,68 @@ +// +// Utility functions used in nf-core DSL2 module files +// + +// +// Extract name of software tool from process name using $task.process +// +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +// +// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules +// +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.args3 = args.args3 ?: '' + options.publish_by_meta = args.publish_by_meta ?: [] + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files + options.suffix = args.suffix ?: '' + return options +} + +// +// Tidy up and join elements of a list to return a path string +// +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +// +// Function to save/publish module results +// +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_meta) { + def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta + for (key in key_list) { + if (args.meta && key instanceof String) { + def path = key + if (args.meta.containsKey(key)) { + path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] + } + path = path instanceof String ? path : '' + path_list.add(path) + } + } + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else if (ioptions.publish_files == null) { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/modules/multiqc/main.nf b/modules/nf-core/modules/multiqc/main.nf new file mode 100644 index 000000000..da7808002 --- /dev/null +++ b/modules/nf-core/modules/multiqc/main.nf @@ -0,0 +1,35 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +params.options = [:] +options = initOptions(params.options) + +process MULTIQC { + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:[:], publish_by_meta:[]) } + + conda (params.enable_conda ? "bioconda::multiqc=1.10.1" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://depot.galaxyproject.org/singularity/multiqc:1.10.1--py_0" + } else { + container "quay.io/biocontainers/multiqc:1.10.1--py_0" + } + + input: + path multiqc_files + + output: + path "*multiqc_report.html", emit: report + path "*_data" , emit: data + path "*_plots" , optional:true, emit: plots + path "*.version.txt" , emit: version + + script: + def software = getSoftwareName(task.process) + """ + multiqc -f $options.args . + multiqc --version | sed -e "s/multiqc, version //g" > ${software}.version.txt + """ +} diff --git a/modules/nf-core/modules/multiqc/meta.yml b/modules/nf-core/modules/multiqc/meta.yml new file mode 100644 index 000000000..532a8bb1e --- /dev/null +++ b/modules/nf-core/modules/multiqc/meta.yml @@ -0,0 +1,39 @@ +name: MultiQC +description: Aggregate results from bioinformatics analyses across many samples into a single report +keywords: + - QC + - bioinformatics tools + - Beautiful stand-alone HTML report +tools: + - multiqc: + description: | + MultiQC searches a given directory for analysis logs and compiles a HTML report. + It's a general use tool, perfect for summarising the output from numerous bioinformatics tools. + homepage: https://multiqc.info/ + documentation: https://multiqc.info/docs/ +input: + - multiqc_files: + type: file + description: | + List of reports / files recognised by MultiQC, for example the html and zip output of FastQC +output: + - report: + type: file + description: MultiQC report file + pattern: "multiqc_report.html" + - data: + type: dir + description: MultiQC data dir + pattern: "multiqc_data" + - plots: + type: file + description: Plots created by MultiQC + pattern: "*_data" + - version: + type: file + description: File containing software version + pattern: "*.{version.txt}" +authors: + - "@abhi18av" + - "@bunop" + - "@drpatelh" diff --git a/modules/nf-core/software/picard/collectmultiplemetrics/functions.nf b/modules/nf-core/modules/picard/collectmultiplemetrics/functions.nf similarity index 97% rename from modules/nf-core/software/picard/collectmultiplemetrics/functions.nf rename to modules/nf-core/modules/picard/collectmultiplemetrics/functions.nf index 75553cdf5..5bafdbe17 100644 --- a/modules/nf-core/software/picard/collectmultiplemetrics/functions.nf +++ b/modules/nf-core/modules/picard/collectmultiplemetrics/functions.nf @@ -1,59 +1,59 @@ -/* - * ----------------------------------------------------- - * Utility functions used in nf-core DSL2 module files - * ----------------------------------------------------- - */ - -/* - * Extract name of software tool from process name using $task.process - */ -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -/* - * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules - */ -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files ?: null - options.suffix = args.suffix ?: '' - return options -} - -/* - * Tidy up and join elements of a list to return a path string - */ -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -/* - * Function to save/publish module results - */ -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_id) { - path_list.add(args.publish_id) - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/picard/collectmultiplemetrics/main.nf b/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf similarity index 97% rename from modules/nf-core/software/picard/collectmultiplemetrics/main.nf rename to modules/nf-core/modules/picard/collectmultiplemetrics/main.nf index 8850d534c..03d5a4c80 100644 --- a/modules/nf-core/software/picard/collectmultiplemetrics/main.nf +++ b/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf @@ -1,47 +1,47 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process PICARD_COLLECTMULTIPLEMETRICS { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/picard:2.23.2--0" - //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" - - conda (params.conda ? "bioconda::picard=2.23.2" : null) - - input: - tuple val(meta), path(bam) - path fasta - val options - - output: - tuple val(meta), path("*_metrics"), emit: metrics - tuple val(meta), path("*.pdf"), emit: pdf - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - def avail_mem = 3 - if (!task.memory) { - log.info '[Picard CollectMultipleMetrics] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' - } else { - avail_mem = task.memory.giga - } - """ - picard \\ - -Xmx${avail_mem}g \\ - CollectMultipleMetrics \\ - $ioptions.args \\ - INPUT=$bam \\ - OUTPUT=${prefix}.CollectMultipleMetrics \\ - REFERENCE_SEQUENCE=$fasta - - echo \$(picard CollectMultipleMetrics --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt - """ -} +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process PICARD_COLLECTMULTIPLEMETRICS { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/picard:2.23.2--0" + //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" + + conda (params.conda ? "bioconda::picard=2.23.2" : null) + + input: + tuple val(meta), path(bam) + path fasta + val options + + output: + tuple val(meta), path("*_metrics"), emit: metrics + tuple val(meta), path("*.pdf"), emit: pdf + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def avail_mem = 3 + if (!task.memory) { + log.info '[Picard CollectMultipleMetrics] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' + } else { + avail_mem = task.memory.giga + } + """ + picard \\ + -Xmx${avail_mem}g \\ + CollectMultipleMetrics \\ + $ioptions.args \\ + INPUT=$bam \\ + OUTPUT=${prefix}.CollectMultipleMetrics \\ + REFERENCE_SEQUENCE=$fasta + + echo \$(picard CollectMultipleMetrics --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/modules/picard/markduplicates/functions.nf b/modules/nf-core/modules/picard/markduplicates/functions.nf new file mode 100644 index 000000000..5bafdbe17 --- /dev/null +++ b/modules/nf-core/modules/picard/markduplicates/functions.nf @@ -0,0 +1,59 @@ +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/picard/markduplicates/main.nf b/modules/nf-core/modules/picard/markduplicates/main.nf similarity index 97% rename from modules/nf-core/software/picard/markduplicates/main.nf rename to modules/nf-core/modules/picard/markduplicates/main.nf index 8bfed2565..b102b4f23 100644 --- a/modules/nf-core/software/picard/markduplicates/main.nf +++ b/modules/nf-core/modules/picard/markduplicates/main.nf @@ -1,46 +1,46 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process PICARD_MARKDUPLICATES { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/picard:2.23.2--0" - //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" - - conda (params.conda ? "bioconda::picard=2.23.2" : null) - - input: - tuple val(meta), path(bam) - val options - - output: - tuple val(meta), path("*.bam"), emit: bam - tuple val(meta), path("*.metrics.txt"), emit: metrics - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - def avail_mem = 3 - if (!task.memory) { - log.info '[Picard MarkDuplicates] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' - } else { - avail_mem = task.memory.giga - } - """ - picard \\ - -Xmx${avail_mem}g \\ - MarkDuplicates \\ - $ioptions.args \\ - INPUT=$bam \\ - OUTPUT=${prefix}.bam \\ - METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt - - echo \$(picard MarkDuplicates --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt - """ -} +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process PICARD_MARKDUPLICATES { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/picard:2.23.2--0" + //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" + + conda (params.conda ? "bioconda::picard=2.23.2" : null) + + input: + tuple val(meta), path(bam) + val options + + output: + tuple val(meta), path("*.bam"), emit: bam + tuple val(meta), path("*.metrics.txt"), emit: metrics + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def avail_mem = 3 + if (!task.memory) { + log.info '[Picard MarkDuplicates] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' + } else { + avail_mem = task.memory.giga + } + """ + picard \\ + -Xmx${avail_mem}g \\ + MarkDuplicates \\ + $ioptions.args \\ + INPUT=$bam \\ + OUTPUT=${prefix}.bam \\ + METRICS_FILE=${prefix}.MarkDuplicates.metrics.txt + + echo \$(picard MarkDuplicates --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/modules/picard/mergesamfiles/functions.nf b/modules/nf-core/modules/picard/mergesamfiles/functions.nf new file mode 100644 index 000000000..5bafdbe17 --- /dev/null +++ b/modules/nf-core/modules/picard/mergesamfiles/functions.nf @@ -0,0 +1,59 @@ +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/picard/mergesamfiles/main.nf b/modules/nf-core/modules/picard/mergesamfiles/main.nf similarity index 97% rename from modules/nf-core/software/picard/mergesamfiles/main.nf rename to modules/nf-core/modules/picard/mergesamfiles/main.nf index 062bbfc85..4e6649d8e 100644 --- a/modules/nf-core/software/picard/mergesamfiles/main.nf +++ b/modules/nf-core/modules/picard/mergesamfiles/main.nf @@ -1,51 +1,51 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process PICARD_MERGESAMFILES { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/picard:2.23.2--0" - //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" - - conda (params.conda ? "bioconda::picard=2.23.2" : null) - - input: - tuple val(meta), path(bams) - val options - - output: - tuple val(meta), path("*.bam"), emit: bam - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - def bam_files = bams.sort() - def avail_mem = 3 - if (!task.memory) { - log.info '[Picard MergeSamFiles] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' - } else { - avail_mem = task.memory.giga - } - if (bam_files.size() > 1) { - """ - picard \\ - -Xmx${avail_mem}g \\ - MergeSamFiles \\ - $ioptions.args \\ - ${'INPUT='+bam_files.join(' INPUT=')} \\ - OUTPUT=${prefix}.bam - echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt - """ - } else { - """ - ln -s ${bam_files[0]} ${prefix}.bam - echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt - """ - } -} +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process PICARD_MERGESAMFILES { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/picard:2.23.2--0" + //container "https://depot.galaxyproject.org/singularity/picard:2.23.2--0" + + conda (params.conda ? "bioconda::picard=2.23.2" : null) + + input: + tuple val(meta), path(bams) + val options + + output: + tuple val(meta), path("*.bam"), emit: bam + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + def bam_files = bams.sort() + def avail_mem = 3 + if (!task.memory) { + log.info '[Picard MergeSamFiles] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' + } else { + avail_mem = task.memory.giga + } + if (bam_files.size() > 1) { + """ + picard \\ + -Xmx${avail_mem}g \\ + MergeSamFiles \\ + $ioptions.args \\ + ${'INPUT='+bam_files.join(' INPUT=')} \\ + OUTPUT=${prefix}.bam + echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt + """ + } else { + """ + ln -s ${bam_files[0]} ${prefix}.bam + echo \$(picard MergeSamFiles --version 2>&1) | awk -F' ' '{print \$NF}' > ${software}.version.txt + """ + } +} diff --git a/modules/nf-core/modules/samtools/flagstat/functions.nf b/modules/nf-core/modules/samtools/flagstat/functions.nf new file mode 100644 index 000000000..5bafdbe17 --- /dev/null +++ b/modules/nf-core/modules/samtools/flagstat/functions.nf @@ -0,0 +1,59 @@ +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/samtools/flagstat/main.nf b/modules/nf-core/modules/samtools/flagstat/main.nf similarity index 97% rename from modules/nf-core/software/samtools/flagstat/main.nf rename to modules/nf-core/modules/samtools/flagstat/main.nf index 4c14a41ae..be9897c48 100644 --- a/modules/nf-core/software/samtools/flagstat/main.nf +++ b/modules/nf-core/modules/samtools/flagstat/main.nf @@ -1,29 +1,29 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process SAMTOOLS_FLAGSTAT { - tag "$meta.id" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/samtools:1.10--h9402c20_2" - //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - - conda (params.conda ? "bioconda::samtools=1.10" : null) - - input: - tuple val(meta), path(bam), path(bai) - val options - - output: - tuple val(meta), path("*.flagstat"), emit: flagstat - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - """ - samtools flagstat $bam > ${bam}.flagstat - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt - """ -} +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process SAMTOOLS_FLAGSTAT { + tag "$meta.id" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "bioconda::samtools=1.10" : null) + + input: + tuple val(meta), path(bam), path(bai) + val options + + output: + tuple val(meta), path("*.flagstat"), emit: flagstat + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + """ + samtools flagstat $bam > ${bam}.flagstat + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/modules/samtools/idxstats/functions.nf b/modules/nf-core/modules/samtools/idxstats/functions.nf new file mode 100644 index 000000000..5bafdbe17 --- /dev/null +++ b/modules/nf-core/modules/samtools/idxstats/functions.nf @@ -0,0 +1,59 @@ +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/samtools/idxstats/main.nf b/modules/nf-core/modules/samtools/idxstats/main.nf similarity index 97% rename from modules/nf-core/software/samtools/idxstats/main.nf rename to modules/nf-core/modules/samtools/idxstats/main.nf index 9805bb141..3934eb4c7 100644 --- a/modules/nf-core/software/samtools/idxstats/main.nf +++ b/modules/nf-core/modules/samtools/idxstats/main.nf @@ -1,29 +1,29 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process SAMTOOLS_IDXSTATS { - tag "$meta.id" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/samtools:1.10--h9402c20_2" - //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - - conda (params.conda ? "bioconda::samtools=1.10" : null) - - input: - tuple val(meta), path(bam), path(bai) - val options - - output: - tuple val(meta), path("*.idxstats"), emit: idxstats - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - """ - samtools idxstats $bam > ${bam}.idxstats - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt - """ -} +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process SAMTOOLS_IDXSTATS { + tag "$meta.id" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "bioconda::samtools=1.10" : null) + + input: + tuple val(meta), path(bam), path(bai) + val options + + output: + tuple val(meta), path("*.idxstats"), emit: idxstats + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + """ + samtools idxstats $bam > ${bam}.idxstats + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/modules/samtools/index/functions.nf b/modules/nf-core/modules/samtools/index/functions.nf new file mode 100644 index 000000000..5bafdbe17 --- /dev/null +++ b/modules/nf-core/modules/samtools/index/functions.nf @@ -0,0 +1,59 @@ +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/samtools/index/main.nf b/modules/nf-core/modules/samtools/index/main.nf similarity index 97% rename from modules/nf-core/software/samtools/index/main.nf rename to modules/nf-core/modules/samtools/index/main.nf index 456e2663d..cc9e6407a 100644 --- a/modules/nf-core/software/samtools/index/main.nf +++ b/modules/nf-core/modules/samtools/index/main.nf @@ -1,29 +1,29 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process SAMTOOLS_INDEX { - tag "$meta.id" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/samtools:1.10--h9402c20_2" - //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - - conda (params.conda ? "bioconda::samtools=1.10" : null) - - input: - tuple val(meta), path(bam) - val options - - output: - tuple val(meta), path("*.bai"), emit: bai - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - """ - samtools index $bam - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt - """ -} +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process SAMTOOLS_INDEX { + tag "$meta.id" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "bioconda::samtools=1.10" : null) + + input: + tuple val(meta), path(bam) + val options + + output: + tuple val(meta), path("*.bai"), emit: bai + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + """ + samtools index $bam + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/samtools/index/meta.yml b/modules/nf-core/modules/samtools/index/meta.yml similarity index 100% rename from modules/nf-core/software/samtools/index/meta.yml rename to modules/nf-core/modules/samtools/index/meta.yml diff --git a/modules/nf-core/modules/samtools/sort/functions.nf b/modules/nf-core/modules/samtools/sort/functions.nf new file mode 100644 index 000000000..5bafdbe17 --- /dev/null +++ b/modules/nf-core/modules/samtools/sort/functions.nf @@ -0,0 +1,59 @@ +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/samtools/sort/main.nf b/modules/nf-core/modules/samtools/sort/main.nf similarity index 97% rename from modules/nf-core/software/samtools/sort/main.nf rename to modules/nf-core/modules/samtools/sort/main.nf index 9467e2aea..68cce0fc2 100644 --- a/modules/nf-core/software/samtools/sort/main.nf +++ b/modules/nf-core/modules/samtools/sort/main.nf @@ -1,32 +1,32 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process SAMTOOLS_SORT { - tag "$meta.id" - label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/samtools:1.10--h9402c20_2" - //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - - conda (params.conda ? "bioconda::samtools=1.10" : null) - - input: - tuple val(meta), path(bam) - val options - - output: - tuple val(meta), path("*.bam"), emit: bam - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - """ - samtools sort $ioptions.args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt - """ -} +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process SAMTOOLS_SORT { + tag "$meta.id" + label 'process_medium' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "bioconda::samtools=1.10" : null) + + input: + tuple val(meta), path(bam) + val options + + output: + tuple val(meta), path("*.bam"), emit: bam + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + """ + samtools sort $ioptions.args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/software/samtools/sort/meta.yml b/modules/nf-core/modules/samtools/sort/meta.yml similarity index 100% rename from modules/nf-core/software/samtools/sort/meta.yml rename to modules/nf-core/modules/samtools/sort/meta.yml diff --git a/modules/nf-core/modules/samtools/stats/functions.nf b/modules/nf-core/modules/samtools/stats/functions.nf new file mode 100644 index 000000000..5bafdbe17 --- /dev/null +++ b/modules/nf-core/modules/samtools/stats/functions.nf @@ -0,0 +1,59 @@ +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/samtools/stats/main.nf b/modules/nf-core/modules/samtools/stats/main.nf similarity index 97% rename from modules/nf-core/software/samtools/stats/main.nf rename to modules/nf-core/modules/samtools/stats/main.nf index 52d5e2d74..a225edff0 100644 --- a/modules/nf-core/software/samtools/stats/main.nf +++ b/modules/nf-core/modules/samtools/stats/main.nf @@ -1,29 +1,29 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process SAMTOOLS_STATS { - tag "$meta.id" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/samtools:1.10--h9402c20_2" - //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - - conda (params.conda ? "bioconda::samtools=1.10" : null) - - input: - tuple val(meta), path(bam), path(bai) - val options - - output: - tuple val(meta), path("*.stats"), emit: stats - path "*.version.txt", emit: version - - script: - def software = getSoftwareName(task.process) - """ - samtools stats $bam > ${bam}.stats - echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt - """ -} +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process SAMTOOLS_STATS { + tag "$meta.id" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" + //container " https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" + + conda (params.conda ? "bioconda::samtools=1.10" : null) + + input: + tuple val(meta), path(bam), path(bai) + val options + + output: + tuple val(meta), path("*.stats"), emit: stats + path "*.version.txt", emit: version + + script: + def software = getSoftwareName(task.process) + """ + samtools stats $bam > ${bam}.stats + echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//' > ${software}.version.txt + """ +} diff --git a/modules/nf-core/modules/trimgalore/functions.nf b/modules/nf-core/modules/trimgalore/functions.nf new file mode 100644 index 000000000..5bafdbe17 --- /dev/null +++ b/modules/nf-core/modules/trimgalore/functions.nf @@ -0,0 +1,59 @@ +/* + * ----------------------------------------------------- + * Utility functions used in nf-core DSL2 module files + * ----------------------------------------------------- + */ + +/* + * Extract name of software tool from process name using $task.process + */ +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +/* + * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules + */ +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.publish_by_id = args.publish_by_id ?: false + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files ?: null + options.suffix = args.suffix ?: '' + return options +} + +/* + * Tidy up and join elements of a list to return a path string + */ +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +/* + * Function to save/publish module results + */ +def saveFiles(Map args) { + if (!args.filename.endsWith('.version.txt')) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + if (ioptions.publish_by_id) { + path_list.add(args.publish_id) + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else { + return "${getPathFromList(path_list)}/$args.filename" + } + } +} diff --git a/modules/nf-core/software/trimgalore/main.nf b/modules/nf-core/modules/trimgalore/main.nf similarity index 97% rename from modules/nf-core/software/trimgalore/main.nf rename to modules/nf-core/modules/trimgalore/main.nf index 219b3e659..eb586e4a5 100644 --- a/modules/nf-core/software/trimgalore/main.nf +++ b/modules/nf-core/modules/trimgalore/main.nf @@ -1,79 +1,79 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -process TRIMGALORE { - tag "$meta.id" - label 'process_high' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } - - container "quay.io/biocontainers/trim-galore:0.6.5--0" - //container "https://depot.galaxyproject.org/singularity/trim-galore:0.6.5--0" - - conda (params.conda ? "bioconda::trim-galore=0.6.5" : null) - - input: - tuple val(meta), path(reads) - val options - - output: - tuple val(meta), path("*.fq.gz"), emit: reads - tuple val(meta), path("*.html"), emit: html optional true - tuple val(meta), path("*.zip"), emit: zip optional true - tuple val(meta), path("*report.txt"), emit: log - path "*.version.txt", emit: version - - script: - // Calculate number of --cores for TrimGalore based on value of task.cpus - // See: https://github.com/FelixKrueger/TrimGalore/blob/master/Changelog.md#version-060-release-on-1-mar-2019 - // See: https://github.com/nf-core/atacseq/pull/65 - def cores = 1 - if (task.cpus) { - cores = (task.cpus as int) - 4 - if (meta.single_end) cores = (task.cpus as int) - 3 - if (cores < 1) cores = 1 - if (cores > 4) cores = 4 - } - - // Clipping presets have to be evaluated in the context of SE/PE - def c_r1 = params.clip_r1 > 0 ? "--clip_r1 ${params.clip_r1}" : '' - def c_r2 = params.clip_r2 > 0 ? "--clip_r2 ${params.clip_r2}" : '' - def tpc_r1 = params.three_prime_clip_r1 > 0 ? "--three_prime_clip_r1 ${params.three_prime_clip_r1}" : '' - def tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' - - // Added soft-links to original fastqs for consistent naming in MultiQC - def software = getSoftwareName(task.process) - def ioptions = initOptions(options) - def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" - if (meta.single_end) { - """ - [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz - trim_galore \\ - $ioptions.args \\ - --cores $cores \\ - --gzip \\ - $c_r1 \\ - $tpc_r1 \\ - ${prefix}.fastq.gz - echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//' > ${software}.version.txt - """ - } else { - """ - [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz - [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz - trim_galore \\ - $ioptions.args \\ - --cores $cores \\ - --paired \\ - --gzip \\ - $c_r1 \\ - $c_r2 \\ - $tpc_r1 \\ - $tpc_r2 \\ - ${prefix}_1.fastq.gz \\ - ${prefix}_2.fastq.gz - echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//' > ${software}.version.txt - """ - } -} +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName } from './functions' + +process TRIMGALORE { + tag "$meta.id" + label 'process_high' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:getSoftwareName(task.process), publish_id:meta.id) } + + container "quay.io/biocontainers/trim-galore:0.6.5--0" + //container "https://depot.galaxyproject.org/singularity/trim-galore:0.6.5--0" + + conda (params.conda ? "bioconda::trim-galore=0.6.5" : null) + + input: + tuple val(meta), path(reads) + val options + + output: + tuple val(meta), path("*.fq.gz"), emit: reads + tuple val(meta), path("*.html"), emit: html optional true + tuple val(meta), path("*.zip"), emit: zip optional true + tuple val(meta), path("*report.txt"), emit: log + path "*.version.txt", emit: version + + script: + // Calculate number of --cores for TrimGalore based on value of task.cpus + // See: https://github.com/FelixKrueger/TrimGalore/blob/master/Changelog.md#version-060-release-on-1-mar-2019 + // See: https://github.com/nf-core/atacseq/pull/65 + def cores = 1 + if (task.cpus) { + cores = (task.cpus as int) - 4 + if (meta.single_end) cores = (task.cpus as int) - 3 + if (cores < 1) cores = 1 + if (cores > 4) cores = 4 + } + + // Clipping presets have to be evaluated in the context of SE/PE + def c_r1 = params.clip_r1 > 0 ? "--clip_r1 ${params.clip_r1}" : '' + def c_r2 = params.clip_r2 > 0 ? "--clip_r2 ${params.clip_r2}" : '' + def tpc_r1 = params.three_prime_clip_r1 > 0 ? "--three_prime_clip_r1 ${params.three_prime_clip_r1}" : '' + def tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' + + // Added soft-links to original fastqs for consistent naming in MultiQC + def software = getSoftwareName(task.process) + def ioptions = initOptions(options) + def prefix = ioptions.suffix ? "${meta.id}${ioptions.suffix}" : "${meta.id}" + if (meta.single_end) { + """ + [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz + trim_galore \\ + $ioptions.args \\ + --cores $cores \\ + --gzip \\ + $c_r1 \\ + $tpc_r1 \\ + ${prefix}.fastq.gz + echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//' > ${software}.version.txt + """ + } else { + """ + [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz + [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz + trim_galore \\ + $ioptions.args \\ + --cores $cores \\ + --paired \\ + --gzip \\ + $c_r1 \\ + $c_r2 \\ + $tpc_r1 \\ + $tpc_r2 \\ + ${prefix}_1.fastq.gz \\ + ${prefix}_2.fastq.gz + echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//' > ${software}.version.txt + """ + } +} diff --git a/modules/nf-core/software/trimgalore/meta.yml b/modules/nf-core/modules/trimgalore/meta.yml similarity index 100% rename from modules/nf-core/software/trimgalore/meta.yml rename to modules/nf-core/modules/trimgalore/meta.yml diff --git a/modules/nf-core/software/picard/markduplicates/functions.nf b/modules/nf-core/software/picard/markduplicates/functions.nf deleted file mode 100644 index 75553cdf5..000000000 --- a/modules/nf-core/software/picard/markduplicates/functions.nf +++ /dev/null @@ -1,59 +0,0 @@ -/* - * ----------------------------------------------------- - * Utility functions used in nf-core DSL2 module files - * ----------------------------------------------------- - */ - -/* - * Extract name of software tool from process name using $task.process - */ -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -/* - * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules - */ -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files ?: null - options.suffix = args.suffix ?: '' - return options -} - -/* - * Tidy up and join elements of a list to return a path string - */ -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -/* - * Function to save/publish module results - */ -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_id) { - path_list.add(args.publish_id) - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} diff --git a/modules/nf-core/software/picard/mergesamfiles/functions.nf b/modules/nf-core/software/picard/mergesamfiles/functions.nf deleted file mode 100644 index 75553cdf5..000000000 --- a/modules/nf-core/software/picard/mergesamfiles/functions.nf +++ /dev/null @@ -1,59 +0,0 @@ -/* - * ----------------------------------------------------- - * Utility functions used in nf-core DSL2 module files - * ----------------------------------------------------- - */ - -/* - * Extract name of software tool from process name using $task.process - */ -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -/* - * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules - */ -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files ?: null - options.suffix = args.suffix ?: '' - return options -} - -/* - * Tidy up and join elements of a list to return a path string - */ -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -/* - * Function to save/publish module results - */ -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_id) { - path_list.add(args.publish_id) - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} diff --git a/modules/nf-core/software/samtools/flagstat/functions.nf b/modules/nf-core/software/samtools/flagstat/functions.nf deleted file mode 100644 index 75553cdf5..000000000 --- a/modules/nf-core/software/samtools/flagstat/functions.nf +++ /dev/null @@ -1,59 +0,0 @@ -/* - * ----------------------------------------------------- - * Utility functions used in nf-core DSL2 module files - * ----------------------------------------------------- - */ - -/* - * Extract name of software tool from process name using $task.process - */ -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -/* - * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules - */ -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files ?: null - options.suffix = args.suffix ?: '' - return options -} - -/* - * Tidy up and join elements of a list to return a path string - */ -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -/* - * Function to save/publish module results - */ -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_id) { - path_list.add(args.publish_id) - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} diff --git a/modules/nf-core/software/samtools/idxstats/functions.nf b/modules/nf-core/software/samtools/idxstats/functions.nf deleted file mode 100644 index 75553cdf5..000000000 --- a/modules/nf-core/software/samtools/idxstats/functions.nf +++ /dev/null @@ -1,59 +0,0 @@ -/* - * ----------------------------------------------------- - * Utility functions used in nf-core DSL2 module files - * ----------------------------------------------------- - */ - -/* - * Extract name of software tool from process name using $task.process - */ -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -/* - * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules - */ -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files ?: null - options.suffix = args.suffix ?: '' - return options -} - -/* - * Tidy up and join elements of a list to return a path string - */ -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -/* - * Function to save/publish module results - */ -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_id) { - path_list.add(args.publish_id) - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} diff --git a/modules/nf-core/software/samtools/index/functions.nf b/modules/nf-core/software/samtools/index/functions.nf deleted file mode 100644 index 75553cdf5..000000000 --- a/modules/nf-core/software/samtools/index/functions.nf +++ /dev/null @@ -1,59 +0,0 @@ -/* - * ----------------------------------------------------- - * Utility functions used in nf-core DSL2 module files - * ----------------------------------------------------- - */ - -/* - * Extract name of software tool from process name using $task.process - */ -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -/* - * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules - */ -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files ?: null - options.suffix = args.suffix ?: '' - return options -} - -/* - * Tidy up and join elements of a list to return a path string - */ -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -/* - * Function to save/publish module results - */ -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_id) { - path_list.add(args.publish_id) - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} diff --git a/modules/nf-core/software/samtools/sort/functions.nf b/modules/nf-core/software/samtools/sort/functions.nf deleted file mode 100644 index 75553cdf5..000000000 --- a/modules/nf-core/software/samtools/sort/functions.nf +++ /dev/null @@ -1,59 +0,0 @@ -/* - * ----------------------------------------------------- - * Utility functions used in nf-core DSL2 module files - * ----------------------------------------------------- - */ - -/* - * Extract name of software tool from process name using $task.process - */ -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -/* - * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules - */ -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files ?: null - options.suffix = args.suffix ?: '' - return options -} - -/* - * Tidy up and join elements of a list to return a path string - */ -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -/* - * Function to save/publish module results - */ -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_id) { - path_list.add(args.publish_id) - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} diff --git a/modules/nf-core/software/samtools/stats/functions.nf b/modules/nf-core/software/samtools/stats/functions.nf deleted file mode 100644 index 75553cdf5..000000000 --- a/modules/nf-core/software/samtools/stats/functions.nf +++ /dev/null @@ -1,59 +0,0 @@ -/* - * ----------------------------------------------------- - * Utility functions used in nf-core DSL2 module files - * ----------------------------------------------------- - */ - -/* - * Extract name of software tool from process name using $task.process - */ -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -/* - * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules - */ -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files ?: null - options.suffix = args.suffix ?: '' - return options -} - -/* - * Tidy up and join elements of a list to return a path string - */ -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -/* - * Function to save/publish module results - */ -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_id) { - path_list.add(args.publish_id) - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} diff --git a/modules/nf-core/software/trimgalore/functions.nf b/modules/nf-core/software/trimgalore/functions.nf deleted file mode 100644 index 75553cdf5..000000000 --- a/modules/nf-core/software/trimgalore/functions.nf +++ /dev/null @@ -1,59 +0,0 @@ -/* - * ----------------------------------------------------- - * Utility functions used in nf-core DSL2 module files - * ----------------------------------------------------- - */ - -/* - * Extract name of software tool from process name using $task.process - */ -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -/* - * Function to initialise default values and to generate a Groovy Map of available options for nf-core modules - */ -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.publish_by_id = args.publish_by_id ?: false - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files ?: null - options.suffix = args.suffix ?: '' - return options -} - -/* - * Tidy up and join elements of a list to return a path string - */ -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -/* - * Function to save/publish module results - */ -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_id) { - path_list.add(args.publish_id) - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} diff --git a/nextflow.config b/nextflow.config index bad267cbc..d102d6385 100644 --- a/nextflow.config +++ b/nextflow.config @@ -1,141 +1,195 @@ /* - * ------------------------------------------------- - * nf-core/chipseq Nextflow config file - * ------------------------------------------------- - * Default config options for all environments. - */ +======================================================================================== + nf-core/chipseq Nextflow config file +======================================================================================== + Default config options for all compute environments +---------------------------------------------------------------------------------------- +*/ // Global default params, used in configs params { + // Input options + input = null + seq_center = '' + fragment_size = 200 + fingerprint_bins = 500000 - // Options: Generic - input = './design.csv' - seq_center = '' - fragment_size = 200 - fingerprint_bins = 500000 - - // Options: References - genome = false - save_reference = false - - // Options: Trimming - clip_r1 = 0 - clip_r2 = 0 - three_prime_clip_r1 = 0 - three_prime_clip_r2 = 0 - trim_nextseq = 0 - skip_trimming = false - save_trimmed = false - - // Options: Alignments - bwa_min_score = false - keep_dups = false - keep_multi_map = false - save_align_intermeds = false - - // Options: Peaks - narrow_peak = false - broad_cutoff = 0.1 - macs_fdr = false - macs_pvalue = false - min_reps_consensus = 1 - save_macs_pileup = false - skip_peak_qc = false - skip_peak_annotation = false - skip_consensus_peaks = false - - // Options: Differential analysis - deseq2_vst = false - skip_diff_analysis = false - - // Options: QC - skip_fastqc = false - skip_picard_metrics = false - skip_preseq = false - skip_plot_profile = false - skip_plot_fingerprint = false - skip_spp = false - skip_igv = false - skip_multiqc = false - - // Options: Config - multiqc_config = false - bamtools_filter_pe_config = "$projectDir/assets/bamtools_filter_pe.json" - bamtools_filter_se_config = "$projectDir/assets/bamtools_filter_se.json" - - // Options: Custom config - custom_config_version = 'master' - custom_config_base = "https://raw.githubusercontent.com/nf-core/configs/${params.custom_config_version}" - config_profile_description = false - config_profile_contact = false - config_profile_url = false - - // Options: Other - conda = false - help = false - outdir = './results' - publish_dir_mode = 'copy' - igenomes_base = 's3://ngi-igenomes/igenomes/' - igenomes_ignore = false - max_multiqc_email_size = 25.MB - tracedir = "${params.outdir}/pipeline_info" - email = false - email_on_fail = false - plaintext_email = false - monochrome_logs = false - name = false - hostnames = false - clusterOptions = false - - // Defaults only, expecting to be overwritten - max_memory = 128.GB - max_cpus = 16 - max_time = 240.h + // References + genome = false + save_reference = false + + // Options: Trimming + clip_r1 = 0 + clip_r2 = 0 + three_prime_clip_r1 = 0 + three_prime_clip_r2 = 0 + trim_nextseq = 0 + skip_trimming = false + save_trimmed = false + + // Options: Alignments + bwa_min_score = false + keep_dups = false + keep_multi_map = false + save_align_intermeds = false + + // Options: Peaks + narrow_peak = false + broad_cutoff = 0.1 + macs_fdr = false + macs_pvalue = false + min_reps_consensus = 1 + save_macs_pileup = false + skip_peak_qc = false + skip_peak_annotation = false + skip_consensus_peaks = false + + // Options: Differential analysis + deseq2_vst = false + skip_diff_analysis = false + + // Options: QC + skip_fastqc = false + skip_picard_metrics = false + skip_preseq = false + skip_plot_profile = false + skip_plot_fingerprint = false + skip_spp = false + skip_igv = false + skip_multiqc = false + + // Options: Config + multiqc_config = false + bamtools_filter_pe_config = "$projectDir/assets/bamtools_filter_pe.json" + bamtools_filter_se_config = "$projectDir/assets/bamtools_filter_se.json" + + // Options: Custom config + custom_config_version = 'master' + custom_config_base = "https://raw.githubusercontent.com/nf-core/configs/${params.custom_config_version}" + config_profile_description = false + config_profile_contact = false + config_profile_url = false + + // Boilerplate options + help = false + outdir = './results' + publish_dir_mode = 'copy' + igenomes_base = 's3://ngi-igenomes/igenomes/' + igenomes_ignore = false + max_multiqc_email_size = 25.MB + tracedir = "${params.outdir}/pipeline_info" + email = false + email_on_fail = false + plaintext_email = false + monochrome_logs = false + // name = false // TODO remove parameter + hostnames = false + validate_params = true + show_hidden_params = false + schema_ignore_params = 'genomes,modules' + enable_conda = false + // TODO substitute conda by enable_conda + conda = false + singularity_pull_docker_container = false + clusterOptions = false // TODO get rid of it (such as in rnaseq 3.1) + + // MultiQC options + multiqc_config = null + multiqc_title = null + max_multiqc_email_size = '25.MB' + + + // Config options + custom_config_version = 'master' + custom_config_base = "https://raw.githubusercontent.com/nf-core/configs/${params.custom_config_version}" + hostnames = [:] + config_profile_description = null + config_profile_contact = null + config_profile_url = null + config_profile_name = null + + // Max resource options + // Defaults only, expecting to be overwritten + max_memory = '128.GB' + max_cpus = 16 + max_time = '240.h' } // Container slug. Stable releases should specify release tag! // Developmental code should specify :dev +// TODO some process will be run by default using this image, they should be refactored process.container = 'nfcore/chipseq:dev' // Load base.config by default for all pipelines includeConfig 'conf/base.config' -// Load modules.config by default for all pipelines +// Load modules.config for DSL2 module specific options includeConfig 'conf/modules.config' // Load nf-core custom profiles from different Institutions try { - includeConfig "${params.custom_config_base}/nfcore_custom.config" + includeConfig "${params.custom_config_base}/nfcore_custom.config" } catch (Exception e) { - System.err.println("WARNING: Could not load nf-core/config profiles: ${params.custom_config_base}/nfcore_custom.config") -} - -profiles { - conda { process.conda = "$projectDir/environment.yml" } - debug { process.beforeScript = 'echo $HOSTNAME' } - docker { - docker.enabled = true - // Avoid this error: - // WARNING: Your kernel does not support swap limit capabilities or the cgroup is not mounted. Memory limited without swap. - // Testing this in nf-core after discussion here https://github.com/nf-core/tools/pull/351 - // once this is established and works well, nextflow might implement this behavior as new default. - docker.runOptions = '-u \$(id -u):\$(id -g)' - } - singularity { - singularity.enabled = true - singularity.autoMounts = true - } - podman { - podman.enabled = true - } - test { includeConfig 'conf/test.config' } - test_full { includeConfig 'conf/test_full.config' } + System.err.println("WARNING: Could not load nf-core/config profiles: ${params.custom_config_base}/nfcore_custom.config") } // Load igenomes.config if required if (!params.igenomes_ignore) { - includeConfig 'conf/igenomes.config' + includeConfig 'conf/igenomes.config' +} else { + params.genomes = [:] +} + +profiles { + debug { process.beforeScript = 'echo $HOSTNAME' } + conda { + params.enable_conda = true + docker.enabled = false + singularity.enabled = false + podman.enabled = false + shifter.enabled = false + charliecloud.enabled = false + } + docker { + docker.enabled = true + docker.userEmulation = true + singularity.enabled = false + podman.enabled = false + shifter.enabled = false + charliecloud.enabled = false + } + singularity { + singularity.enabled = true + singularity.autoMounts = true + docker.enabled = false + podman.enabled = false + shifter.enabled = false + charliecloud.enabled = false + } + podman { + podman.enabled = true + docker.enabled = false + singularity.enabled = false + shifter.enabled = false + charliecloud.enabled = false + } + shifter { + shifter.enabled = true + docker.enabled = false + singularity.enabled = false + podman.enabled = false + charliecloud.enabled = false + } + charliecloud { + charliecloud.enabled = true + docker.enabled = false + singularity.enabled = false + podman.enabled = false + shifter.enabled = false + } + test { includeConfig 'conf/test.config' } + test_full { includeConfig 'conf/test_full.config' } } // Increase time available to build conda environment @@ -143,70 +197,71 @@ conda { createTimeout = "60 min" } // Export these variables to prevent local Python/R libraries from conflicting with those in the container env { - PYTHONNOUSERSITE = 1 - R_PROFILE_USER = "/.Rprofile" - R_ENVIRON_USER = "/.Renviron" + PYTHONNOUSERSITE = 1 + R_PROFILE_USER = "/.Rprofile" + R_ENVIRON_USER = "/.Renviron" } // Capture exit codes from upstream processes when piping process.shell = ['/bin/bash', '-euo', 'pipefail'] +def trace_timestamp = new java.util.Date().format( 'yyyy-MM-dd_HH-mm-ss') timeline { - enabled = true - file = "${params.tracedir}/execution_timeline.html" + enabled = true + file = "${params.tracedir}/execution_timeline_${trace_timestamp}.html" } report { - enabled = true - file = "${params.tracedir}/execution_report.html" + enabled = true + file = "${params.tracedir}/execution_report_${trace_timestamp}.html" } trace { - enabled = true - file = "${params.tracedir}/execution_trace.txt" + enabled = true + file = "${params.tracedir}/execution_trace_${trace_timestamp}.txt" } dag { - enabled = true - file = "${params.tracedir}/pipeline_dag.svg" + enabled = true + file = "${params.tracedir}/pipeline_dag_${trace_timestamp}.svg" } manifest { - name = 'nf-core/chipseq' - author = 'Philip Ewels' - homePage = 'https://github.com/nf-core/chipseq' - description = 'ChIP-seq peak-calling and differential analysis pipeline.' - mainScript = 'main.nf' - nextflowVersion = '>=20.07.1' - version = '1.3.0dev' + name = 'nf-core/chipseq' + author = 'Philip Ewels' + homePage = 'https://github.com/nf-core/chipseq' + description = 'ChIP-seq peak-calling and differential analysis pipeline.' + mainScript = 'main.nf' + nextflowVersion = '!>=21.04.0' + version = '1.3.0dev' } // Function to ensure that resource requirements don't go beyond // a maximum limit def check_max(obj, type) { - if (type == 'memory') { - try { - if (obj.compareTo(params.max_memory as nextflow.util.MemoryUnit) == 1) - return params.max_memory as nextflow.util.MemoryUnit - else - return obj - } catch (all) { - println " ### ERROR ### Max memory '${params.max_memory}' is not valid! Using default value: $obj" - return obj - } - } else if (type == 'time') { - try { - if (obj.compareTo(params.max_time as nextflow.util.Duration) == 1) - return params.max_time as nextflow.util.Duration - else - return obj - } catch (all) { - println " ### ERROR ### Max time '${params.max_time}' is not valid! Using default value: $obj" - return obj - } - } else if (type == 'cpus') { - try { - return Math.min( obj, params.max_cpus as int ) - } catch (all) { - println " ### ERROR ### Max cpus '${params.max_cpus}' is not valid! Using default value: $obj" - return obj + if (type == 'memory') { + try { + if (obj.compareTo(params.max_memory as nextflow.util.MemoryUnit) == 1) + return params.max_memory as nextflow.util.MemoryUnit + else + return obj + } catch (all) { + println " ### ERROR ### Max memory '${params.max_memory}' is not valid! Using default value: $obj" + return obj + } + } else if (type == 'time') { + try { + if (obj.compareTo(params.max_time as nextflow.util.Duration) == 1) + return params.max_time as nextflow.util.Duration + else + return obj + } catch (all) { + println " ### ERROR ### Max time '${params.max_time}' is not valid! Using default value: $obj" + return obj + } + } else if (type == 'cpus') { + try { + return Math.min( obj, params.max_cpus as int ) + } catch (all) { + println " ### ERROR ### Max cpus '${params.max_cpus}' is not valid! Using default value: $obj" + return obj + } } - } } diff --git a/nextflow_schema.json b/nextflow_schema.json index de8f02cbf..1024fcdce 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -16,10 +16,13 @@ "properties": { "input": { "type": "string", + "format": "file-path", + "mimetype": "text/csv", + "pattern": "^\\S+\\.csv$", + "schema": "assets/schema_input.json", "description": "Path to comma-separated file containing information about the samples in the experiment.", "help_text": "You will need to create a design file with information about the samples in your experiment before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 6 columns, and a header row. See [usage docs](https://nf-co.re/chipseq/docs/usage#introduction).", - "fa_icon": "fas fa-file-csv", - "default": "./design.csv" + "fa_icon": "fas fa-file-csv" }, "fragment_size": { "type": "integer", @@ -44,6 +47,11 @@ "fa_icon": "fas fa-envelope", "help_text": "Set this parameter to your e-mail address to get a summary e-mail with details of the run sent to you when the workflow exits. If set in your user config file (`~/.nextflow/config`) then you don't need to specify this on the command line for every run.", "pattern": "^([a-zA-Z0-9_\\-\\.]+)@([a-zA-Z0-9_\\-\\.]+)\\.([a-zA-Z]{2,5})$" + }, + "multiqc_title": { + "type": "string", + "description": "MultiQC report title. Printed as page header, used for filename if not otherwise specified.", + "fa_icon": "fas fa-file-signature" } } }, @@ -61,6 +69,9 @@ }, "fasta": { "type": "string", + "format": "file-path", + "mimetype": "text/plain", + "pattern": "^\\S+\\.fn?a(sta)?(\\.gz)?$", "description": "Path to FASTA genome file.", "help_text": "This parameter is *mandatory* if `--genome` is not specified. If you don't have a BWA index available this will be generated for you automatically. Combine with `--save_reference` to save BWA index for future runs.", "fa_icon": "far fa-file-code" @@ -82,7 +93,7 @@ "fa_icon": "fas fa-procedures" }, "macs_gsize": { - "type": "string", + "type": "number", "description": "Effective genome size parameter required by MACS2.", "help_text": "[Effective genome size](https://github.com/taoliu/MACS#-g--gsize) parameter required by MACS2. If using an iGenomes reference these have been provided when `--genome` is set as *GRCh37*, *GRCh38*, *GRCm38*, *WBcel235*, *BDGP6*, *R64-1-1*, *EF2*, *hg38*, *hg19* and *mm10*. For other genomes, if this parameter is not specified then the MACS2 peak-calling and differential analysis will be skipped.", "fa_icon": "fas fa-arrows-alt-h" @@ -101,8 +112,9 @@ }, "igenomes_base": { "type": "string", + "format": "directory-path", "description": "Directory / URL base for iGenomes references.", - "default": "s3://ngi-igenomes/igenomes/", + "default": "s3://ngi-igenomes/igenomes", "fa_icon": "fas fa-cloud-download-alt", "hidden": true }, @@ -356,6 +368,12 @@ "hidden": true, "fa_icon": "fas fa-users-cog" }, + "config_profile_name": { + "type": "string", + "description": "Institutional config name.", + "hidden": true, + "fa_icon": "fas fa-users-cog" + }, "config_profile_description": { "type": "string", "description": "Institutional config description.", @@ -396,6 +414,7 @@ "description": "Maximum amount of memory that can be requested for any single job.", "default": "128.GB", "fa_icon": "fas fa-memory", + "pattern": "^\\d+(\\.\\d+)?\\.?\\s*(K|M|G|T)?B$", "hidden": true, "help_text": "Use to set an upper-limit for the memory requirement for each process. Should be a string in the format integer-unit e.g. `--max_memory '8.GB'`" }, @@ -404,6 +423,7 @@ "description": "Maximum amount of time that can be requested for any single job.", "default": "240.h", "fa_icon": "far fa-clock", + "pattern": "^(\\d+\\.?\\s*(s|m|h|day)\\s*)+$", "hidden": true, "help_text": "Use to set an upper-limit for the time requirement for each process. Should be a string in the format integer-unit e.g. `--max_time '2.h'`" } @@ -445,13 +465,6 @@ ], "hidden": true }, - "name": { - "type": "string", - "description": "Workflow name.", - "fa_icon": "fas fa-address-card", - "help_text": "A custom name for the pipeline run. Unlike the core nextflow `-name` option with one hyphen this parameter can be reused multiple times, for example if using `-resume`. Passed through to steps such as MultiQC and used for things like report filenames and titles.", - "hidden": true - }, "email_on_fail": { "type": "string", "description": "Email address for completion summary, only when pipeline fails.", @@ -469,6 +482,7 @@ "max_multiqc_email_size": { "type": "string", "description": "File size limit when attaching MultiQC reports to summary emails.", + "pattern": "^\\d+(\\.\\d+)?\\.?\\s*(K|M|G|T)?B$", "default": "25.MB", "fa_icon": "fas fa-file-upload", "hidden": true @@ -492,16 +506,32 @@ "fa_icon": "fas fa-cogs", "hidden": true }, - "clusterOptions": { - "type": "string", - "description": "Arguments passed to Nextflow clusterOptions.", - "fa_icon": "fas fa-network-wired", + "validate_params": { + "type": "boolean", + "description": "Boolean whether to validate parameters against the schema at runtime", + "default": true, + "fa_icon": "fas fa-check-square", "hidden": true }, - "conda": { + "show_hidden_params": { "type": "boolean", - "description": "Run this workflow with Conda.", - "hidden": true + "fa_icon": "far fa-eye-slash", + "description": "Show all params when using `--help`", + "hidden": true, + "help_text": "By default, parameters set as _hidden_ in the schema are not shown on the command line when a user runs with `--help`. Specifying this option will tell the pipeline to show all parameters." + }, + "enable_conda": { + "type": "boolean", + "description": "Run this workflow with Conda. You can also use '-profile conda' instead of providing this parameter.", + "hidden": true, + "fa_icon": "fas fa-bacon" + }, + "singularity_pull_docker_container": { + "type": "boolean", + "description": "Instead of directly downloading Singularity images for use with Singularity, force the workflow to pull and convert Docker containers instead.", + "hidden": true, + "fa_icon": "fas fa-toolbox", + "help_text": "This may be useful for example if you are unable to directly pull Singularity containers to run the pipeline due to http/https proxy issues." } } } diff --git a/modules/local/subworkflow/bam_clean.nf b/subworkflows/local/bam_clean.nf similarity index 80% rename from modules/local/subworkflow/bam_clean.nf rename to subworkflows/local/bam_clean.nf index e9813fddd..69c74a8ae 100644 --- a/modules/local/subworkflow/bam_clean.nf +++ b/subworkflows/local/bam_clean.nf @@ -1,32 +1,34 @@ -/* - * Filter BAM file - */ - -include { BAM_FILTER } from '../process/bam_filter' -include { BAM_REMOVE_ORPHANS } from '../process/bam_remove_orphans' -include { BAM_SORT_SAMTOOLS } from '../../nf-core/subworkflow/bam_sort_samtools' - -workflow BAM_CLEAN { - take: - ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] - ch_bed // channel: [ bed ] - bamtools_filter_se_config // file: BAMtools filter JSON config file for SE data - bamtools_filter_pe_config // file: BAMtools filter JSON config file for PE data - bam_filter_options // map: options for bam_filter module - bam_remove_orphans_options // map: options for bam_remove_orphans module - samtools_options // map: options for SAMTools modules - - main: - BAM_FILTER(ch_bam_bai, ch_bed, bamtools_filter_se_config, bamtools_filter_pe_config, bam_filter_options) - BAM_REMOVE_ORPHANS(BAM_FILTER.out.bam, bam_remove_orphans_options) - BAM_SORT_SAMTOOLS(BAM_REMOVE_ORPHANS.out.bam, samtools_options) - - emit: - name_bam = BAM_REMOVE_ORPHANS.out.bam // channel: [ val(meta), [ bam ] ] - bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] - bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] - stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - bamtools_version = BAM_FILTER.out.version // path: *.version.txt -} +/* + * Filter BAM file + */ + +// include { BAM_FILTER } from '../process/bam_filter' +// include { BAM_REMOVE_ORPHANS } from '../process/bam_remove_orphans' +include { BAM_FILTER } from '../../modules/local/bam_filter' +include { BAM_REMOVE_ORPHANS } from '../../modules/local/bam_remove_orphans' +include { BAM_SORT_SAMTOOLS } from '../nf-core/bam_sort_samtools' + +workflow BAM_CLEAN { + take: + ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] + ch_bed // channel: [ bed ] + bamtools_filter_se_config // file: BAMtools filter JSON config file for SE data + bamtools_filter_pe_config // file: BAMtools filter JSON config file for PE data + bam_filter_options // map: options for bam_filter module + bam_remove_orphans_options // map: options for bam_remove_orphans module + samtools_options // map: options for SAMTools modules + + main: + BAM_FILTER(ch_bam_bai, ch_bed, bamtools_filter_se_config, bamtools_filter_pe_config, bam_filter_options) + BAM_REMOVE_ORPHANS(BAM_FILTER.out.bam, bam_remove_orphans_options) + BAM_SORT_SAMTOOLS(BAM_REMOVE_ORPHANS.out.bam, samtools_options) + + emit: + name_bam = BAM_REMOVE_ORPHANS.out.bam // channel: [ val(meta), [ bam ] ] + bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] + bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + bamtools_version = BAM_FILTER.out.version // path: *.version.txt +} diff --git a/modules/local/process/samplesheet_check.nf b/subworkflows/local/input_check.nf similarity index 53% rename from modules/local/process/samplesheet_check.nf rename to subworkflows/local/input_check.nf index c4057e977..fca645273 100644 --- a/modules/local/process/samplesheet_check.nf +++ b/subworkflows/local/input_check.nf @@ -1,28 +1,28 @@ -// Import generic module functions -include { saveFiles } from './functions' +// +// Check input samplesheet and get read channels +// -/* - * Reformat design file, check validitiy and create IP vs control mappings - */ -process SAMPLESHEET_CHECK { - tag "$samplesheet" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"pipeline_info", publish_id:'') } - - conda (params.conda ? "${baseDir}/environment.yml" : null) +params.options = [:] - input: - path samplesheet - val options +include { SAMPLESHEET_CHECK } from '../../modules/local/samplesheet_check' addParams( options: params.options ) - output: - path '*.csv' - - script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - """ - check_samplesheet.py $samplesheet samplesheet.valid.csv - """ +/* + * Check input samplesheet and get read channels + */ +workflow INPUT_CHECK { + take: + ch_input // file: /path/to/samplesheet.csv + seq_center // string: sequencing center for read group + samplesheet_check_options // map: options for check_samplesheet module + + main: + SAMPLESHEET_CHECK (ch_input, samplesheet_check_options) + .splitCsv(header:true, sep:',') + .map { get_samplesheet_paths(it, seq_center) } + .set { ch_reads } + + emit: + reads = ch_reads // channel: [ val(meta), [ reads ] ] } // Function to get list of [ meta, [ fastq_1, fastq_2 ] ] diff --git a/modules/nf-core/subworkflow/bam_sort_samtools.nf b/subworkflows/nf-core/bam_sort_samtools.nf similarity index 83% rename from modules/nf-core/subworkflow/bam_sort_samtools.nf rename to subworkflows/nf-core/bam_sort_samtools.nf index d55b9aad1..4a65e700b 100644 --- a/modules/nf-core/subworkflow/bam_sort_samtools.nf +++ b/subworkflows/nf-core/bam_sort_samtools.nf @@ -1,26 +1,27 @@ -/* - * Sort, index BAM file and run samtools stats, flagstat and idxstats - */ - -include { SAMTOOLS_SORT } from '../software/samtools/sort/main' -include { SAMTOOLS_INDEX } from '../software/samtools/index/main' -include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' - -workflow BAM_SORT_SAMTOOLS { - take: - ch_bam // channel: [ val(meta), [ bam ] ] - samtools_options // map: options for SAMTools modules - - main: - SAMTOOLS_SORT(ch_bam, samtools_options) - SAMTOOLS_INDEX(SAMTOOLS_SORT.out.bam, samtools_options) - BAM_STATS_SAMTOOLS(SAMTOOLS_SORT.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_options) - - emit: - bam = SAMTOOLS_SORT.out.bam // channel: [ val(meta), [ bam ] ] - bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] - stats = BAM_STATS_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = BAM_STATS_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = BAM_STATS_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - samtools_version = SAMTOOLS_SORT.out.version // path: *.version.txt -} +/* + * Sort, index BAM file and run samtools stats, flagstat and idxstats + */ + +// TODO add addParams +include { SAMTOOLS_SORT } from '../../modules/nf-core/modules/samtools/sort/main' +include { SAMTOOLS_INDEX } from '../../modules/nf-core/modules/samtools/index/main' +include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' + +workflow BAM_SORT_SAMTOOLS { + take: + ch_bam // channel: [ val(meta), [ bam ] ] + samtools_options // map: options for SAMTools modules + + main: + SAMTOOLS_SORT(ch_bam, samtools_options) + SAMTOOLS_INDEX(SAMTOOLS_SORT.out.bam, samtools_options) + BAM_STATS_SAMTOOLS(SAMTOOLS_SORT.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_options) + + emit: + bam = SAMTOOLS_SORT.out.bam // channel: [ val(meta), [ bam ] ] + bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_STATS_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_STATS_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_STATS_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + samtools_version = SAMTOOLS_SORT.out.version // path: *.version.txt +} diff --git a/modules/nf-core/subworkflow/bam_stats_samtools.nf b/subworkflows/nf-core/bam_stats_samtools.nf similarity index 73% rename from modules/nf-core/subworkflow/bam_stats_samtools.nf rename to subworkflows/nf-core/bam_stats_samtools.nf index 669ae6a54..031990f13 100644 --- a/modules/nf-core/subworkflow/bam_stats_samtools.nf +++ b/subworkflows/nf-core/bam_stats_samtools.nf @@ -1,24 +1,24 @@ -/* - * Run SAMtools stats, flagstat and idxstats - */ - -include { SAMTOOLS_STATS } from '../software/samtools/stats/main' -include { SAMTOOLS_IDXSTATS } from '../software/samtools/idxstats/main' -include { SAMTOOLS_FLAGSTAT } from '../software/samtools/flagstat/main' - -workflow BAM_STATS_SAMTOOLS { - take: - ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] - samtools_options // map: options for SAMTools modules - - main: - SAMTOOLS_STATS(ch_bam_bai, samtools_options) - SAMTOOLS_FLAGSTAT(ch_bam_bai, samtools_options) - SAMTOOLS_IDXSTATS(ch_bam_bai, samtools_options) - - emit: - stats = SAMTOOLS_STATS.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = SAMTOOLS_FLAGSTAT.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = SAMTOOLS_IDXSTATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - samtools_version = SAMTOOLS_STATS.out.version // path: *.version.txt -} +/* + * Run SAMtools stats, flagstat and idxstats + */ + +include { SAMTOOLS_STATS } from '../../modules/nf-core/modules/samtools/stats/main' +include { SAMTOOLS_IDXSTATS } from '../../modules/nf-core/modules/samtools/idxstats/main' +include { SAMTOOLS_FLAGSTAT } from '../../modules/nf-core/modules/samtools/flagstat/main' + +workflow BAM_STATS_SAMTOOLS { + take: + ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] + samtools_options // map: options for SAMTools modules + + main: + SAMTOOLS_STATS(ch_bam_bai, samtools_options) + SAMTOOLS_FLAGSTAT(ch_bam_bai, samtools_options) + SAMTOOLS_IDXSTATS(ch_bam_bai, samtools_options) + + emit: + stats = SAMTOOLS_STATS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = SAMTOOLS_FLAGSTAT.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = SAMTOOLS_IDXSTATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + samtools_version = SAMTOOLS_STATS.out.version // path: *.version.txt +} diff --git a/modules/nf-core/subworkflow/fastqc_trimgalore.nf b/subworkflows/nf-core/fastqc_trimgalore.nf similarity index 90% rename from modules/nf-core/subworkflow/fastqc_trimgalore.nf rename to subworkflows/nf-core/fastqc_trimgalore.nf index 365d313dc..2ca67dde1 100644 --- a/modules/nf-core/subworkflow/fastqc_trimgalore.nf +++ b/subworkflows/nf-core/fastqc_trimgalore.nf @@ -1,49 +1,49 @@ -/* - * Read QC and trimming - */ - -include { FASTQC } from '../software/fastqc/main' -include { TRIMGALORE } from '../software/trimgalore/main' - -workflow FASTQC_TRIMGALORE { - take: - ch_reads // channel: [ val(meta), [ reads ] ] - skip_fastqc // boolean: true/false - skip_trimming // boolean: true/false - fastqc_options // map: options for FastQC module - trimgalore_options // map: options for TrimGalore! module - - main: - fastqc_html = Channel.empty() - fastqc_zip = Channel.empty() - fastqc_version = Channel.empty() - if (!skip_fastqc) { - FASTQC(ch_reads, fastqc_options).html.set { fastqc_html } - fastqc_zip = FASTQC.out.zip - fastqc_version = FASTQC.out.version - } - - ch_trim_reads = ch_reads - trim_html = Channel.empty() - trim_zip = Channel.empty() - trim_log = Channel.empty() - trimgalore_version = Channel.empty() - if (!skip_trimming) { - TRIMGALORE(ch_reads, trimgalore_options).reads.set { ch_trim_reads } - trim_html = TRIMGALORE.out.html - trim_zip = TRIMGALORE.out.zip - trim_log = TRIMGALORE.out.log - trimgalore_version = TRIMGALORE.out.version - } - - emit: - fastqc_html // channel: [ val(meta), [ html ] ] - fastqc_zip // channel: [ val(meta), [ zip ] ] - fastqc_version // path: *.version.txt - - reads = ch_trim_reads // channel: [ val(meta), [ reads ] ] - trim_html // channel: [ val(meta), [ html ] ] - trim_zip // channel: [ val(meta), [ zip ] ] - trim_log // channel: [ val(meta), [ txt ] ] - trimgalore_version // path: *.version.txt -} +/* + * Read QC and trimming + */ + +include { FASTQC } from '../../modules/nf-core/modules/fastqc/main' +include { TRIMGALORE } from '../../modules/nf-core/modules/trimgalore/main' + +workflow FASTQC_TRIMGALORE { + take: + ch_reads // channel: [ val(meta), [ reads ] ] + skip_fastqc // boolean: true/false + skip_trimming // boolean: true/false + fastqc_options // map: options for FastQC module + trimgalore_options // map: options for TrimGalore! module + + main: + fastqc_html = Channel.empty() + fastqc_zip = Channel.empty() + fastqc_version = Channel.empty() + if (!skip_fastqc) { + FASTQC(ch_reads, fastqc_options).html.set { fastqc_html } + fastqc_zip = FASTQC.out.zip + fastqc_version = FASTQC.out.version + } + + ch_trim_reads = ch_reads + trim_html = Channel.empty() + trim_zip = Channel.empty() + trim_log = Channel.empty() + trimgalore_version = Channel.empty() + if (!skip_trimming) { + TRIMGALORE(ch_reads, trimgalore_options).reads.set { ch_trim_reads } + trim_html = TRIMGALORE.out.html + trim_zip = TRIMGALORE.out.zip + trim_log = TRIMGALORE.out.log + trimgalore_version = TRIMGALORE.out.version + } + + emit: + fastqc_html // channel: [ val(meta), [ html ] ] + fastqc_zip // channel: [ val(meta), [ zip ] ] + fastqc_version // path: *.version.txt + + reads = ch_trim_reads // channel: [ val(meta), [ reads ] ] + trim_html // channel: [ val(meta), [ html ] ] + trim_zip // channel: [ val(meta), [ zip ] ] + trim_log // channel: [ val(meta), [ txt ] ] + trimgalore_version // path: *.version.txt +} diff --git a/modules/nf-core/subworkflow/map_bwa_mem.nf b/subworkflows/nf-core/map_bwa_mem.nf similarity index 93% rename from modules/nf-core/subworkflow/map_bwa_mem.nf rename to subworkflows/nf-core/map_bwa_mem.nf index f46077e4b..79fdbd6bc 100644 --- a/modules/nf-core/subworkflow/map_bwa_mem.nf +++ b/subworkflows/nf-core/map_bwa_mem.nf @@ -1,28 +1,28 @@ -/* - * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats - */ - -include { BWA_MEM } from '../software/bwa/mem/main' -include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' - -workflow MAP_BWA_MEM { - take: - ch_reads // channel: [ val(meta), [ reads ] ] - ch_index // path: /path/to/index - ch_fasta // path: /path/to/genome.fasta - bwa_mem_options // map: options for BWA MEM module - samtools_options // map: options for SAMTools modules - - main: - BWA_MEM(ch_reads, ch_index, ch_fasta, bwa_mem_options) - BAM_SORT_SAMTOOLS(BWA_MEM.out.bam, samtools_options) - - emit: - bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] - bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] - stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - bwa_version = BWA_MEM.out.version // path: *.version.txt - samtools_version = BAM_SORT_SAMTOOLS.out.samtools_version // path: *.version.txt -} +/* + * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats + */ + +include { BWA_MEM } from '../../modules/nf-core/modules/bwa/mem/main' +include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' + +workflow MAP_BWA_MEM { + take: + ch_reads // channel: [ val(meta), [ reads ] ] + ch_index // path: /path/to/index + ch_fasta // path: /path/to/genome.fasta + bwa_mem_options // map: options for BWA MEM module + samtools_options // map: options for SAMTools modules + + main: + BWA_MEM(ch_reads, ch_index, ch_fasta, bwa_mem_options) + BAM_SORT_SAMTOOLS(BWA_MEM.out.bam, samtools_options) + + emit: + bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] + bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + bwa_version = BWA_MEM.out.version // path: *.version.txt + samtools_version = BAM_SORT_SAMTOOLS.out.samtools_version // path: *.version.txt +} diff --git a/modules/nf-core/subworkflow/mark_duplicates_picard.nf b/subworkflows/nf-core/mark_duplicates_picard.nf similarity index 88% rename from modules/nf-core/subworkflow/mark_duplicates_picard.nf rename to subworkflows/nf-core/mark_duplicates_picard.nf index f147831f5..a8ba9bed4 100644 --- a/modules/nf-core/subworkflow/mark_duplicates_picard.nf +++ b/subworkflows/nf-core/mark_duplicates_picard.nf @@ -1,29 +1,29 @@ -/* - * Picard MarkDuplicates, sort, index BAM file and run samtools stats, flagstat and idxstats - */ - -include { PICARD_MARKDUPLICATES } from '../software/picard/markduplicates/main' -include { SAMTOOLS_INDEX } from '../software/samtools/index/main' -include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' - -workflow MARK_DUPLICATES_PICARD { - take: - ch_bam // channel: [ val(meta), [ bam ] ] - markduplicates_options // map: options for picard MarkDuplicates module - samtools_options // map: options for SAMTools modules - - main: - PICARD_MARKDUPLICATES(ch_bam, markduplicates_options) - SAMTOOLS_INDEX(PICARD_MARKDUPLICATES.out.bam, samtools_options) - BAM_STATS_SAMTOOLS(PICARD_MARKDUPLICATES.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_options) - - emit: - bam = PICARD_MARKDUPLICATES.out.bam // channel: [ val(meta), [ bam ] ] - metrics = PICARD_MARKDUPLICATES.out.metrics // channel: [ val(meta), [ metrics ] ] - bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] - stats = BAM_STATS_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = BAM_STATS_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = BAM_STATS_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - picard_version = PICARD_MARKDUPLICATES.out.version // path: *.version.txt - samtools_version = SAMTOOLS_INDEX.out.version // path: *.version.txt -} +/* + * Picard MarkDuplicates, sort, index BAM file and run samtools stats, flagstat and idxstats + */ + +include { PICARD_MARKDUPLICATES } from '../../modules/nf-core/modules/picard/markduplicates/main' +include { SAMTOOLS_INDEX } from '../../modules/nf-core/modules/samtools/index/main' +include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' + +workflow MARK_DUPLICATES_PICARD { + take: + ch_bam // channel: [ val(meta), [ bam ] ] + markduplicates_options // map: options for picard MarkDuplicates module + samtools_options // map: options for SAMTools modules + + main: + PICARD_MARKDUPLICATES(ch_bam, markduplicates_options) + SAMTOOLS_INDEX(PICARD_MARKDUPLICATES.out.bam, samtools_options) + BAM_STATS_SAMTOOLS(PICARD_MARKDUPLICATES.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0]), samtools_options) + + emit: + bam = PICARD_MARKDUPLICATES.out.bam // channel: [ val(meta), [ bam ] ] + metrics = PICARD_MARKDUPLICATES.out.metrics // channel: [ val(meta), [ metrics ] ] + bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_STATS_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_STATS_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_STATS_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + picard_version = PICARD_MARKDUPLICATES.out.version // path: *.version.txt + samtools_version = SAMTOOLS_INDEX.out.version // path: *.version.txt +} diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf new file mode 100644 index 000000000..aed9dcaf2 --- /dev/null +++ b/workflows/chipseq.nf @@ -0,0 +1,628 @@ +/* +======================================================================================== + VALIDATE INPUTS +======================================================================================== +*/ + +def summary_params = NfcoreSchema.paramsSummaryMap(workflow, params) + +// Validate input parameters +WorkflowChipseq.initialise(params, log) + +// Check input path parameters to see if they exist +def checkPathParamList = [ + params.input, params.multiqc_config, + params.fasta, + params.gtf, params.gene_bed, + params.bwa_index, + params.blacklist, + params.bamtools_filter_pe_config, params.bamtools_filter_se_config +] + +for (param in checkPathParamList) { if (param) { file(param, checkIfExists: true) } } + +// Check mandatory parameters +if (params.input) { ch_input = file(params.input) } else { exit 1, 'Input samplesheet not specified!' } + +// Check fasta reference file +if (params.fasta) { ch_fasta = file(params.fasta, checkIfExists: true) } else { exit 1, 'Fasta file not specified!' } + +// Check gtf annotation file +if (params.gtf) { ch_gtf = file(params.gtf, checkIfExists: true) } else { exit 1, 'GTF annotation file not specified!' } + +// Check bed annotation file +if (params.gene_bed) { ch_gene_bed = file(params.gene_bed, checkIfExists: true) } + +// Check bed blacklist file +if (params.blacklist) { + ch_blacklist = Channel.fromPath(params.blacklist, checkIfExists: true) +} else { + ch_blacklist = Channel.empty() +} + +// Save AWS IGenomes file containing annotation version +def anno_readme = params.genomes[ params.genome ]?.readme +if (anno_readme && file(anno_readme).exists()) { + file("${params.outdir}/genome/").mkdirs() + file(anno_readme).copyTo("${params.outdir}/genome/") +} + +// If --gtf is supplied along with --genome +// Make gene bed from supplied --gtf instead of using iGenomes one automatically +def makeBED = false +if (!params.gene_bed) { + makeBED = true +} else if (params.genome && params.gtf) { + if (params.genomes[ params.genome ].gtf != params.gtf) { + makeBED = true + } +} + +/* +======================================================================================== + CONFIG FILES +======================================================================================== +*/ + +ch_multiqc_config = file("$projectDir/assets/multiqc_config.yaml", checkIfExists: true) +ch_multiqc_custom_config = params.multiqc_config ? Channel.fromPath(params.multiqc_config) : Channel.empty() +ch_output_docs = file("$projectDir/docs/output.md", checkIfExists: true) +ch_output_docs_images = file("$projectDir/docs/images/", checkIfExists: true) + +// JSON files required by BAMTools for alignment filtering +ch_bamtools_filter_se_config = file(params.bamtools_filter_se_config, checkIfExists: true) +ch_bamtools_filter_pe_config = file(params.bamtools_filter_pe_config, checkIfExists: true) + +// Header files for MultiQC +ch_spp_nsc_header = file("$projectDir/assets/multiqc/spp_nsc_header.txt", checkIfExists: true) +ch_spp_rsc_header = file("$projectDir/assets/multiqc/spp_rsc_header.txt", checkIfExists: true) +ch_spp_correlation_header = file("$projectDir/assets/multiqc/spp_correlation_header.txt", checkIfExists: true) +ch_peak_count_header = file("$projectDir/assets/multiqc/peak_count_header.txt", checkIfExists: true) +ch_frip_score_header = file("$projectDir/assets/multiqc/frip_score_header.txt", checkIfExists: true) +ch_peak_annotation_header = file("$projectDir/assets/multiqc/peak_annotation_header.txt", checkIfExists: true) +ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) +ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) + +/* +======================================================================================== + IMPORT LOCAL MODULES/SUBWORKFLOWS +======================================================================================== +*/ + +// Don't overwrite global params.modules, create a copy instead and use that within the main script. +def modules = params.modules.clone() + +// +// MODULE: Local to the pipeline +// +include { GTF2BED } from '../modules/local/gtf2bed' +include { GET_CHROM_SIZES } from '../modules/local/get_chrom_sizes' +include { MAKE_GENOME_FILTER } from '../modules/local/make_genome_filter' +include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_genomecov' +include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' +include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' +include { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS } from '../modules/local/multiqc_custom_phantompeakqualtools' +include { MULTIQC_CUSTOM_PEAKS } from '../modules/local/multiqc_custom_peaks' +include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' +include { FRIP_SCORE } from '../modules/local/frip_score' +//include { DESEQ2_FEATURECOUNTS } from '../modules/local/deseq2_featurecounts' +include { IGV } from '../modules/local/igv' +include { OUTPUT_DOCUMENTATION } from '../modules/local/output_documentation' +include { GET_SOFTWARE_VERSIONS } from '../modules/local/get_software_versions' //HERE +// TODO template version below to be removed +// include { GET_SOFTWARE_VERSIONS } from '../modules/local/get_software_versions' addParams( options: [publish_files : ['tsv':'']] ) +include { MULTIQC } from '../modules/local/multiqc' + +// +// SUBWORKFLOW: Consisting of a mix of local and nf-core/modules +// +include { INPUT_CHECK } from '../subworkflows/local/input_check' addParams( options: [:] ) +include { BAM_CLEAN } from '../subworkflows/local/bam_clean' addParams( options: [:] ) + +/* +======================================================================================== + IMPORT NF-CORE MODULES/SUBWORKFLOWS +======================================================================================== +*/ + +def multiqc_options = modules['multiqc'] +multiqc_options.args += params.multiqc_title ? Utils.joinModuleArgs(["--title \"$params.multiqc_title\""]) : '' + +// +// MODULE: Installed directly from nf-core/modules +// +include { FASTQC } from '../modules/nf-core/modules/fastqc/main' addParams( options: modules['fastqc'] ) +// include { MULTIQC } from '../modules/nf-core/modules/multiqc/main' addParams( options: multiqc_options ) // TODO review +include { BWA_INDEX } from '../modules/nf-core/modules/bwa/index/main' +include { PICARD_MERGESAMFILES } from '../modules/nf-core/modules/picard/mergesamfiles/main' +include { PICARD_COLLECTMULTIPLEMETRICS } from '../modules/nf-core/modules/picard/collectmultiplemetrics/main' +include { PRESEQ_LCEXTRAP } from '../modules/nf-core/software/preseq/lcextrap/main' +include { UCSC_BEDRAPHTOBIGWIG } from '../modules/nf-core/software/ucsc/bedgraphtobigwig/main' +include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/software/deeptools/computematrix/main' +include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/software/deeptools/plotprofile/main' +include { DEEPTOOLS_PLOTHEATMAP } from '../modules/nf-core/software/deeptools/plotheatmap/main' +include { DEEPTOOLS_PLOTFINGERPRINT } from '../modules/nf-core/software/deeptools/plotfingerprint/main' +include { PHANTOMPEAKQUALTOOLS } from '../modules/nf-core/software/phantompeakqualtools/main' +include { MACS2_CALLPEAK } from '../modules/nf-core/software/macs2/callpeak/main' +include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 + HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../modules/nf-core/software/homer/annotatepeaks/main' +include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/software/subread/featurecounts/main' + +// TODO place correctly the local subworflows +include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' +include { MAP_BWA_MEM } from '../subworkflows/nf-core/map_bwa_mem' +include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' + +/* +======================================================================================== + RUN MAIN WORKFLOW +======================================================================================== +*/ + +// Info required for completion email and summary +def multiqc_report = [] + +workflow CHIPSEQ { + + ch_software_versions = Channel.empty() + + // + // SUBWORKFLOW: Read in samplesheet, validate and stage input files + // + INPUT_CHECK ( + ch_input, + params.seq_center, + [:] + ) + + // + // MODULE: Run FastQC + // + // TODO check if this fastqc process from nf-core is needed Don't think so done in FASTQC_TRIMGALORE + // FASTQC ( + // INPUT_CHECK.out.reads + // ) + // ch_software_versions = ch_software_versions.mix(FASTQC.out.version.first().ifEmpty(null)) + + // + // SUBWORKFLOW: Prepare genome files + // + ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta, params.modules['bwa_index'] ).index + + if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf, [:] ) } + + MAKE_GENOME_FILTER ( + GET_CHROM_SIZES ( ch_fasta, [:] ).sizes, + ch_blacklist.ifEmpty([]), + [:] + ) + ch_software_versions = Channel.empty() + ch_software_versions = ch_software_versions.mix(MAKE_GENOME_FILTER.out.version.first().ifEmpty(null)) + + // + // SUBWORKFLOW: Read QC & trimming + // + nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' + params.modules['trimgalore'].args += nextseq + FASTQC_TRIMGALORE ( + INPUT_CHECK.out.reads, + params.skip_fastqc, + params.skip_trimming, + params.modules['fastqc'], + params.modules['trimgalore'] + ) + ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.fastqc_version.first().ifEmpty(null)) + ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.trimgalore_version.first().ifEmpty(null)) + + // + // SUBWORKFLOW: Map reads & BAM QC + // + score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' + params.modules['bwa_mem'].args += score + MAP_BWA_MEM ( + FASTQC_TRIMGALORE.out.reads, + ch_index, + ch_fasta, + params.modules['bwa_mem'], + params.modules['samtools_sort_lib'] + ) + ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.bwa_version.first()) + ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.samtools_version.first().ifEmpty(null)) + + // + // SUBWORKFLOW: Merge resequenced BAM files + // + MAP_BWA_MEM + .out + .bam + .map { + meta, bam -> + fmeta = meta.findAll { it.key != 'read_group' } + fmeta.id = fmeta.id.split('_')[0..-2].join('_') + [ fmeta, bam ] } + .groupTuple(by: [0]) + .map { it -> [ it[0], it[1].flatten() ] } + .set { ch_sort_bam } + + PICARD_MERGESAMFILES ( + ch_sort_bam, + params.modules['picard_mergesamfiles'] + ) + ch_software_versions = ch_software_versions.mix(PICARD_MERGESAMFILES.out.version.first().ifEmpty(null)) + + // + // SUBWORKFLOW: Mark duplicates & filter BAM files + // + MARK_DUPLICATES_PICARD ( + PICARD_MERGESAMFILES.out.bam, + params.modules['picard_markduplicates'], + params.modules['samtools_sort_merged_lib'] + ) + + // + // SUBWORKFLOW: Fix getting name sorted BAM here for PE/SE + // + BAM_CLEAN ( + MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), + MAKE_GENOME_FILTER.out.bed.collect(), + ch_bamtools_filter_se_config, + ch_bamtools_filter_pe_config, + params.modules['bam_filter'], + params.modules['bam_remove_orphans'], + params.modules['samtools_sort_filter'] + ) + ch_software_versions = ch_software_versions.mix(BAM_CLEAN.out.bamtools_version.first().ifEmpty(null)) + + // + // MODULE: Post alignment QC + // + PICARD_COLLECTMULTIPLEMETRICS ( + BAM_CLEAN.out.bam, + ch_fasta, + params.modules['picard_collectmultiplemetrics'] + ) + + // + // MODULE: Library coverage + // + PRESEQ_LCEXTRAP ( + BAM_CLEAN.out.bam, + params.modules['preseq_lcextrap'] + ) + ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.version.first().ifEmpty(null)) + + // + // MODULE: Strand cross-correlation + // + PHANTOMPEAKQUALTOOLS ( + BAM_CLEAN.out.bam, + params.modules['phantompeakqualtools'] + ) + ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.version.first().ifEmpty(null)) + + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( + PHANTOMPEAKQUALTOOLS.out.spp.join(PHANTOMPEAKQUALTOOLS.out.rdata, by: [0]), + ch_spp_nsc_header, + ch_spp_rsc_header, + ch_spp_correlation_header, + params.modules['multiqc_custom_phantompeakqualtools'] + ) + + // + // MODULE: Coverage tracks + // + BEDTOOLS_GENOMECOV ( + BAM_CLEAN.out.bam.join(BAM_CLEAN.out.flagstat, by: [0]), + params.modules['bedtools_genomecov'] + ) + + // + // MODULE: Coverage tracks + // + UCSC_BEDRAPHTOBIGWIG ( + BEDTOOLS_GENOMECOV.out.bedgraph, + GET_CHROM_SIZES.out.sizes, + params.modules['ucsc_bedgraphtobigwig'] + ) + ch_software_versions = ch_software_versions.mix(UCSC_BEDRAPHTOBIGWIG.out.version.first().ifEmpty(null)) + + // + // MODULE: Coverage plots + // + DEEPTOOLS_COMPUTEMATRIX ( + UCSC_BEDRAPHTOBIGWIG.out.bigwig, + ch_gene_bed, + params.modules['deeptools_computematrix'] + ) + ch_software_versions = ch_software_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.version.first().ifEmpty(null)) + + DEEPTOOLS_PLOTPROFILE ( + DEEPTOOLS_COMPUTEMATRIX.out.matrix, + params.modules['deeptools_plotprofile'] + ) + + DEEPTOOLS_PLOTHEATMAP ( + DEEPTOOLS_COMPUTEMATRIX.out.matrix, + params.modules['deeptools_plotheatmap'] + ) + + // + // Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] + // + BAM_CLEAN + .out + .bam + .join ( BAM_CLEAN.out.bai, by: [0] ) + .map { meta, bam, bai -> meta.control ? null : [ meta.id, [ bam ] , [ bai ] ] } + .set { ch_control_bam_bai } + + BAM_CLEAN + .out + .bam + .join ( BAM_CLEAN.out.bai, by: [0] ) + .map { meta, bam, bai -> meta.control ? [ meta.control, meta, [ bam ], [ bai ] ] : null } + .combine(ch_control_bam_bai, by: 0) + .map { it -> [ it[1] , it[2] + it[4], it[3] + it[5] ] } + .set { ch_ip_control_bam_bai } + + // + // plotFingerprint for IP and control together + // + params.modules['deeptools_plotfingerprint'].args += " --numberOfSamples $params.fingerprint_bins" + DEEPTOOLS_PLOTFINGERPRINT ( + ch_ip_control_bam_bai, + params.modules['deeptools_plotfingerprint'] + ) + + peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' + if (params.macs_gsize) { + + // + // Call peaks + // + broad = params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}" + pileup = params.save_macs_pileup ? '--bdg --SPMR' : '' + fdr = params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '' + pvalue = params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' + params.modules['macs2_callpeak'].publish_dir += "/$peakType" + params.modules['macs2_callpeak'].args += " $broad $pileup $fdr $pvalue" + + // Create channel: [ val(meta), ip_bam, control_bam ] + ch_ip_control_bam_bai + .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } + .set { ch_ip_control_bam } + + MACS2_CALLPEAK ( + ch_ip_control_bam, + params.macs_gsize, + params.modules['macs2_callpeak'] + ) + ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.version.first().ifEmpty(null)) + + ch_ip_control_bam + .join(MACS2_CALLPEAK.out.peak, by: [0]) + .map { it -> [ it[0], it[1], it[3] ] } + .set { ch_ip_peak } + FRIP_SCORE ( + ch_ip_peak, + params.modules['frip_score'] + ) + + ch_ip_peak + .join(FRIP_SCORE.out.txt, by: [0]) + .map { it -> [ it[0], it[2], it[3] ] } + .set { ch_ip_peak_frip } + MULTIQC_CUSTOM_PEAKS ( + ch_ip_peak_frip, + ch_peak_count_header, + ch_frip_score_header, + params.modules['multiqc_custom_peaks'] + ) + + params.modules['plot_macs2_qc'].publish_dir += "/$peakType/qc" + PLOT_MACS2_QC ( + MACS2_CALLPEAK.out.peak.collect{it[1]}, + params.modules['plot_macs2_qc'] + ) + + params.modules['homer_annotatepeaks_macs2'].publish_dir += "/$peakType" + HOMER_ANNOTATEPEAKS_MACS2 ( + MACS2_CALLPEAK.out.peak, + ch_fasta, + ch_gtf, + params.modules['homer_annotatepeaks_macs2'] + ) + ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.version.first().ifEmpty(null)) + + params.modules['plot_homer_annotatepeaks'].publish_dir += "/$peakType/qc" + PLOT_HOMER_ANNOTATEPEAKS ( + HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, + ch_peak_annotation_header, + "_peaks.annotatePeaks.txt", + params.modules['plot_homer_annotatepeaks'] + ) + + // Create channel: [ meta , [ peaks ] ] + // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] + MACS2_CALLPEAK + .out + .peak + .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } + .groupTuple() + .map { + antibody, groups, peaks -> + [ antibody, + groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, + peaks ] } + .map { + antibody, groups, peaks -> + def meta = [:] + meta.id = antibody + meta.multiple_groups = groups.size() > 1 + meta.replicates_exist = groups.max { groups.value }.value > 1 + [ meta, peaks ] } + .set { ch_antibody_peaks } + + params.modules['macs2_consensus'].publish_dir += "/$peakType/consensus" + MACS2_CONSENSUS ( + ch_antibody_peaks, + params.modules['macs2_consensus'] + ) + + params.modules['homer_annotatepeaks_consensus'].publish_dir += "/$peakType/consensus" + HOMER_ANNOTATEPEAKS_CONSENSUS ( + MACS2_CONSENSUS.out.bed, + ch_fasta, + ch_gtf, + params.modules['homer_annotatepeaks_consensus'] + ) + // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt + // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt + + // Create channel: [ val(meta), ip_bam ] + MACS2_CONSENSUS + .out + .saf + .map { meta, saf -> [ meta.id, meta, saf ] } + .set { ch_ip_saf } + + ch_ip_control_bam + .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } + .combine(ch_ip_saf) + .map { + it -> + fmeta = it[1] + fmeta['replicates_exist'] = it[4]['replicates_exist'] + fmeta['multiple_groups'] = it[4]['multiple_groups'] + [ fmeta, it[2], it[5] ] } + .set { ch_ip_bam } + + params.modules['subread_featurecounts'].publish_dir += "/$peakType/consensus" + SUBREAD_FEATURECOUNTS ( + ch_ip_bam, + params.modules['subread_featurecounts'] + ) + ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.version.first().ifEmpty(null)) + + // + // DESEQ2_FEATURECOUNTS ( + // params.modules['deseq2_featurecounts'] + // ) + // ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) + // ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) + + } + + // + // Create IGV session + // + IGV ( + ch_fasta, + UCSC_BEDRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), + MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), + MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), + params.modules['ucsc_bedgraphtobigwig'], + params.modules['macs2_callpeak'], + params.modules['macs2_consensus'], + [:] + ) + + // + // MODULE: Pipeline reporting + // + ch_software_versions + .map { it -> if (it) [ it.baseName, it ] } + .groupTuple() + .map { it[1][0] } + .flatten() + .collect() + .set { ch_software_versions } + + GET_SOFTWARE_VERSIONS ( + ch_software_versions.map { it }.collect() //, + // params.modules['get_software_versions'] // TODO check if its needed, I think that addParams does the trick + ) + + OUTPUT_DOCUMENTATION ( + ch_output_docs, + ch_output_docs_images, + [:] + ) + + // + // MODULE: MultiQC + // + // ch_multiqc_files = Channel.empty() + // ch_multiqc_files = ch_multiqc_files.mix(Channel.from(ch_multiqc_config)) + // ch_multiqc_files = ch_multiqc_files.mix(ch_multiqc_custom_config.collect().ifEmpty([])) + // ch_multiqc_files = ch_multiqc_files.mix(ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml')) + // ch_multiqc_files = ch_multiqc_files.mix(GET_SOFTWARE_VERSIONS.out.yaml.collect()) + // ch_multiqc_files = ch_multiqc_files.mix(FASTQC.out.zip.collect{it[1]}.ifEmpty([])) + + if (!params.skip_multiqc) { + workflow_summary = WorkflowChipseq.paramsSummaryMultiqc(workflow, summary_params) + ch_workflow_summary = Channel.value(workflow_summary) + // params.modules['multiqc'].publish_dir += "/$peakType" // TODO place this in template 2.1 version + + MULTIQC ( + ch_multiqc_config, + ch_multiqc_custom_config.collect().ifEmpty([]), + GET_SOFTWARE_VERSIONS.out.yaml.collect(), + ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml'), + + FASTQC_TRIMGALORE.out.fastqc_zip.collect{it[1]}.ifEmpty([]), + FASTQC_TRIMGALORE.out.trim_log.collect{it[1]}.ifEmpty([]), + FASTQC_TRIMGALORE.out.trim_zip.collect{it[1]}.ifEmpty([]), + + MAP_BWA_MEM.out.stats.collect{it[1]}, + MAP_BWA_MEM.out.flagstat.collect{it[1]}, + MAP_BWA_MEM.out.idxstats.collect{it[1]}, + + MARK_DUPLICATES_PICARD.out.stats.collect{it[1]}.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.flagstat.collect{it[1]}.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.idxstats.collect{it[1]}.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.metrics.collect{it[1]}.ifEmpty([]), + + BAM_CLEAN.out.stats.collect{it[1]}.ifEmpty([]), + BAM_CLEAN.out.flagstat.collect{it[1]}.ifEmpty([]), + BAM_CLEAN.out.idxstats.collect{it[1]}.ifEmpty([]), + PICARD_COLLECTMULTIPLEMETRICS.out.metrics.collect{it[1]}.ifEmpty([]), + + PRESEQ_LCEXTRAP.out.ccurve.collect{it[1]}.ifEmpty([]), + DEEPTOOLS_PLOTPROFILE.out.table.collect{it[1]}.ifEmpty([]), + DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect{it[1]}.ifEmpty([]), + PHANTOMPEAKQUALTOOLS.out.spp.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.nsc.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.rsc.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.correlation.collect{it[1]}.ifEmpty([]), + + MULTIQC_CUSTOM_PEAKS.out.count.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PEAKS.out.frip.collect{it[1]}.ifEmpty([]), + PLOT_HOMER_ANNOTATEPEAKS.out.tsv.collect().ifEmpty([]), + SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), + // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) + + params.modules['multiqc'] // TODO check if needed, addParams should do it, now is declare as input + ) + multiqc_report = MULTIQC.out.report.toList() + } +} + +/* +======================================================================================== + COMPLETION EMAIL AND SUMMARY +======================================================================================== +*/ + +workflow.onComplete { + if (params.email || params.email_on_fail) { + NfcoreTemplate.email(workflow, params, summary_params, projectDir, log, multiqc_report) + } + NfcoreTemplate.summary(workflow, params, log) +} + +/* +======================================================================================== + THE END +======================================================================================== +*/ From d537fe8cee93992095b4968207cbe6a0ff9f9af4 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 9 Sep 2021 18:13:11 +0200 Subject: [PATCH 175/538] Fix lint --- .editorconfig | 3 + CHANGELOG.md | 16 +-- CITATIONS.md | 49 ++++----- assets/bamtools_filter_pe.json | 6 +- assets/bamtools_filter_se.json | 2 +- bin/featurecounts_deseq2.r | 16 +-- bin/gtf2bed | 126 +++++++++++----------- bin/markdown_to_html.py | 32 +++--- bin/plot_homer_annotatepeaks.r | 76 ++++++------- bin/plot_macs2_qc.r | 52 ++++----- docs/output.md | 108 +++++++++---------- lib/Schema.groovy | 24 ++--- lib/WorkflowChipseq.groovy | 8 +- modules/local/plot_homer_annotatepeaks.nf | 2 +- workflows/chipseq.nf | 19 ++-- 15 files changed, 273 insertions(+), 266 deletions(-) diff --git a/.editorconfig b/.editorconfig index 95549501a..57d9144e8 100644 --- a/.editorconfig +++ b/.editorconfig @@ -25,3 +25,6 @@ indent_size = unset [/assets/email*] indent_size = unset + +[/assets/blacklists/GRCh37-blacklist.bed] +trim_trailing_whitespace = unset diff --git a/CHANGELOG.md b/CHANGELOG.md index fd40908b0..822cb4966 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -52,14 +52,14 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 * Replace `set` with `tuple` and `file()` with `path()` in all processes * Capitalise process names * Parameters: - * `--bwa_min_score` to set minimum alignment score for BWA MEM - * `--macs_fdr` to provide FDR threshold for MACS2 peak calling - * `--macs_pvalue` to provide p-value threshold for MACS2 peak calling - * `--skip_peak_qc` to skip MACS2 peak QC plot generation - * `--skip_peak_annotation` to skip annotation of MACS2 and consensus peaks with HOMER - * `--skip_consensus_peaks` to skip consensus peak generation - * `--deseq2_vst` to use variance stabilizing transformation (VST) instead of regularized log transformation (rlog) with DESeq2 - * `--publish_dir_mode` to customise method of publishing results to output directory [nf-core/tools#585](https://github.com/nf-core/tools/issues/585) + * `--bwa_min_score` to set minimum alignment score for BWA MEM + * `--macs_fdr` to provide FDR threshold for MACS2 peak calling + * `--macs_pvalue` to provide p-value threshold for MACS2 peak calling + * `--skip_peak_qc` to skip MACS2 peak QC plot generation + * `--skip_peak_annotation` to skip annotation of MACS2 and consensus peaks with HOMER + * `--skip_consensus_peaks` to skip consensus peak generation + * `--deseq2_vst` to use variance stabilizing transformation (VST) instead of regularized log transformation (rlog) with DESeq2 + * `--publish_dir_mode` to customise method of publishing results to output directory [nf-core/tools#585](https://github.com/nf-core/tools/issues/585) ### `Removed` diff --git a/CITATIONS.md b/CITATIONS.md index bae3ea84f..53fa3bd24 100644 --- a/CITATIONS.md +++ b/CITATIONS.md @@ -1,4 +1,5 @@ # nf-core/chipseq: Citations + ## [nf-core](https://pubmed.ncbi.nlm.nih.gov/32055031/) > Ewels PA, Peltzer A, Fillinger S, Patel H, Alneberg J, Wilm A, Garcia MU, Di Tommaso P, Nahnsen S. The nf-core framework for community-curated bioinformatics pipelines. Nat Biotechnol. 2020 Mar;38(3):276-278. doi: 10.1038/s41587-020-0439-x. PubMed PMID: 32055031. @@ -9,40 +10,40 @@ ## Pipeline tools * [BWA](https://www.ncbi.nlm.nih.gov/pubmed/19451168/) - > Li H, Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 2009 Jul 15;25(14):1754-60. doi: 10.1093/bioinformatics/btp324. Epub 2009 May 18. PubMed PMID: 19451168; PubMed Central PMCID: PMC2705234. + > Li H, Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 2009 Jul 15;25(14):1754-60. doi: 10.1093/bioinformatics/btp324. Epub 2009 May 18. PubMed PMID: 19451168; PubMed Central PMCID: PMC2705234. * [BEDTools](https://www.ncbi.nlm.nih.gov/pubmed/20110278/) - > Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010 Mar 15;26(6):841-2. doi: 10.1093/bioinformatics/btq033. Epub 2010 Jan 28. PubMed PMID: 20110278; PubMed Central PMCID: PMC2832824. + > Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010 Mar 15;26(6):841-2. doi: 10.1093/bioinformatics/btq033. Epub 2010 Jan 28. PubMed PMID: 20110278; PubMed Central PMCID: PMC2832824. * [SAMtools](https://www.ncbi.nlm.nih.gov/pubmed/19505943/) - > Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R; 1000 Genome Project Data Processing Subgroup. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 2009 Aug 15;25(16):2078-9. doi: 10.1093/bioinformatics/btp352. Epub 2009 Jun 8. PubMed PMID: 19505943; PubMed Central PMCID: PMC2723002. + > Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R; 1000 Genome Project Data Processing Subgroup. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 2009 Aug 15;25(16):2078-9. doi: 10.1093/bioinformatics/btp352. Epub 2009 Jun 8. PubMed PMID: 19505943; PubMed Central PMCID: PMC2723002. * [BamTools](https://www.ncbi.nlm.nih.gov/pubmed/21493652/) - > Barnett DW, Garrison EK, Quinlan AR, Strömberg MP, Marth GT. BamTools: a C++ API and toolkit for analyzing and managing BAM files. Bioinformatics. 2011 Jun 15;27(12):1691-2. doi: 10.1093/bioinformatics/btr174. Epub 2011 Apr 14. PubMed PMID: 21493652; PubMed Central PMCID: PMC3106182. + > Barnett DW, Garrison EK, Quinlan AR, Strömberg MP, Marth GT. BamTools: a C++ API and toolkit for analyzing and managing BAM files. Bioinformatics. 2011 Jun 15;27(12):1691-2. doi: 10.1093/bioinformatics/btr174. Epub 2011 Apr 14. PubMed PMID: 21493652; PubMed Central PMCID: PMC3106182. * [UCSC tools](https://www.ncbi.nlm.nih.gov/pubmed/20639541/) - > Kent WJ, Zweig AS, Barber G, Hinrichs AS, Karolchik D. BigWig and BigBed: enabling browsing of large distributed datasets. Bioinformatics. 2010 Sep 1;26(17):2204-7. doi: 10.1093/bioinformatics/btq351. Epub 2010 Jul 17. PubMed PMID: 20639541; PubMed Central PMCID: PMC2922891. + > Kent WJ, Zweig AS, Barber G, Hinrichs AS, Karolchik D. BigWig and BigBed: enabling browsing of large distributed datasets. Bioinformatics. 2010 Sep 1;26(17):2204-7. doi: 10.1093/bioinformatics/btq351. Epub 2010 Jul 17. PubMed PMID: 20639541; PubMed Central PMCID: PMC2922891. * [preseq](https://www.ncbi.nlm.nih.gov/pubmed/23435259/) - > Daley T, Smith AD. Predicting the molecular complexity of sequencing libraries. Nat Methods. 2013 Apr;10(4):325-7. doi: 10.1038/nmeth.2375. Epub 2013 Feb 24. PubMed PMID: 23435259; PubMed Central PMCID: PMC3612374. + > Daley T, Smith AD. Predicting the molecular complexity of sequencing libraries. Nat Methods. 2013 Apr;10(4):325-7. doi: 10.1038/nmeth.2375. Epub 2013 Feb 24. PubMed PMID: 23435259; PubMed Central PMCID: PMC3612374. * [deepTools](https://www.ncbi.nlm.nih.gov/pubmed/27079975/) - > Ramírez F, Ryan DP, Grüning B, Bhardwaj V, Kilpert F, Richter AS, Heyne S, Dündar F, Manke T. deepTools2: a next generation web server for deep-sequencing data analysis. Nucleic Acids Res. 2016 Jul 8;44(W1):W160-5. doi: 10.1093/nar/gkw257. Epub 2016 Apr 13. PubMed PMID: 27079975; PubMed Central PMCID: PMC4987876. + > Ramírez F, Ryan DP, Grüning B, Bhardwaj V, Kilpert F, Richter AS, Heyne S, Dündar F, Manke T. deepTools2: a next generation web server for deep-sequencing data analysis. Nucleic Acids Res. 2016 Jul 8;44(W1):W160-5. doi: 10.1093/nar/gkw257. Epub 2016 Apr 13. PubMed PMID: 27079975; PubMed Central PMCID: PMC4987876. * [MACS2](https://www.ncbi.nlm.nih.gov/pubmed/18798982/) - > Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W, Liu XS. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008;9(9):R137. doi: 10.1186/gb-2008-9-9-r137. Epub 2008 Sep 17. PubMed PMID: 18798982; PubMed Central PMCID: PMC2592715. + > Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W, Liu XS. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008;9(9):R137. doi: 10.1186/gb-2008-9-9-r137. Epub 2008 Sep 17. PubMed PMID: 18798982; PubMed Central PMCID: PMC2592715. * [HOMER](https://www.ncbi.nlm.nih.gov/pubmed/20513432/) - > Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010 May 28;38(4):576-89. doi: 10.1016/j.molcel.2010.05.004. PubMed PMID: 20513432; PubMed Central PMCID: PMC2898526. + > Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010 May 28;38(4):576-89. doi: 10.1016/j.molcel.2010.05.004. PubMed PMID: 20513432; PubMed Central PMCID: PMC2898526. * [phantompeakqualtools](https://www.ncbi.nlm.nih.gov/pubmed/22955991/) - > Landt SG, Marinov GK, Kundaje A, Kheradpour P, Pauli F, Batzoglou S, Bernstein BE, Bickel P, Brown JB, Cayting P, Chen Y, DeSalvo G, Epstein C, Fisher-Aylor KI, Euskirchen G, Gerstein M, Gertz J, Hartemink AJ, Hoffman MM, Iyer VR, Jung YL, Karmakar S, Kellis M, Kharchenko PV, Li Q, Liu T, Liu XS, Ma L, Milosavljevic A, Myers RM, Park PJ, Pazin MJ, Perry MD, Raha D, Reddy TE, Rozowsky J, Shoresh N, Sidow A, Slattery M, Stamatoyannopoulos JA, Tolstorukov MY, White KP, Xi S, Farnham PJ, Lieb JD, Wold BJ, Snyder M. ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res. 2012 Sep;22(9):1813-31. doi: 10.1101/gr.136184.111. PubMed PMID: 22955991; PubMed Central PMCID: PMC3431496. + > Landt SG, Marinov GK, Kundaje A, Kheradpour P, Pauli F, Batzoglou S, Bernstein BE, Bickel P, Brown JB, Cayting P, Chen Y, DeSalvo G, Epstein C, Fisher-Aylor KI, Euskirchen G, Gerstein M, Gertz J, Hartemink AJ, Hoffman MM, Iyer VR, Jung YL, Karmakar S, Kellis M, Kharchenko PV, Li Q, Liu T, Liu XS, Ma L, Milosavljevic A, Myers RM, Park PJ, Pazin MJ, Perry MD, Raha D, Reddy TE, Rozowsky J, Shoresh N, Sidow A, Slattery M, Stamatoyannopoulos JA, Tolstorukov MY, White KP, Xi S, Farnham PJ, Lieb JD, Wold BJ, Snyder M. ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res. 2012 Sep;22(9):1813-31. doi: 10.1101/gr.136184.111. PubMed PMID: 22955991; PubMed Central PMCID: PMC3431496. * [featureCounts](https://www.ncbi.nlm.nih.gov/pubmed/24227677/) - > Liao Y, Smyth GK, Shi W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014 Apr 1;30(7):923-30. doi: 10.1093/bioinformatics/btt656. Epub 2013 Nov 13. PubMed PMID: 24227677. + > Liao Y, Smyth GK, Shi W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014 Apr 1;30(7):923-30. doi: 10.1093/bioinformatics/btt656. Epub 2013 Nov 13. PubMed PMID: 24227677. * [MultiQC](https://pubmed.ncbi.nlm.nih.gov/27312411/) - > Ewels P, Magnusson M, Lundin S, Käller M. MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics. 2016 Oct 1;32(19):3047-8. doi: 10.1093/bioinformatics/btw354. Epub 2016 Jun 16. PubMed PMID: 27312411; PubMed Central PMCID: PMC5039924. + > Ewels P, Magnusson M, Lundin S, Käller M. MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics. 2016 Oct 1;32(19):3047-8. doi: 10.1093/bioinformatics/btw354. Epub 2016 Jun 16. PubMed PMID: 27312411; PubMed Central PMCID: PMC5039924. * [FastQC](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/) @@ -55,40 +56,40 @@ ## R packages * [R](https://www.R-project.org/) - > R Core Team (2017). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. + > R Core Team (2017). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. * [DESeq2](https://www.ncbi.nlm.nih.gov/pubmed/25516281/) - > Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550. PubMed PMID: 25516281; PubMed Central PMCID: PMC4302049. + > Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550. PubMed PMID: 25516281; PubMed Central PMCID: PMC4302049. * [vsn](https://bioconductor.org/packages/release/bioc/html/vsn.html) - > Wolfgang Huber, Anja von Heydebreck, Holger Sueltmann, Annemarie Poustka and Martin Vingron. Variance Stabilization Applied to Microarray Data Calibration and to the Quantification of Differential Expression. Bioinformatics 18, S96-S104 (2002). + > Wolfgang Huber, Anja von Heydebreck, Holger Sueltmann, Annemarie Poustka and Martin Vingron. Variance Stabilization Applied to Microarray Data Calibration and to the Quantification of Differential Expression. Bioinformatics 18, S96-S104 (2002). * [UpSetR](https://CRAN.R-project.org/package=UpSetR) - > Nils Gehlenborg (2017). UpSetR: A More Scalable Alternative to Venn and Euler Diagrams for Visualizing Intersecting Sets. + > Nils Gehlenborg (2017). UpSetR: A More Scalable Alternative to Venn and Euler Diagrams for Visualizing Intersecting Sets. * [ggplot2](https://cran.r-project.org/web/packages/ggplot2/index.html) - > H. Wickham. ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag New York, 2016. + > H. Wickham. ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag New York, 2016. * [reshape2](http://www.jstatsoft.org/v21/i12/) - > Hadley Wickham (2007). Reshaping Data with the reshape Package. Journal of Statistical Software, 21(12), 1-20. + > Hadley Wickham (2007). Reshaping Data with the reshape Package. Journal of Statistical Software, 21(12), 1-20. * [scales](https://CRAN.R-project.org/package=scales) - > Hadley Wickham (2018). scales: Scale Functions for Visualization. + > Hadley Wickham (2018). scales: Scale Functions for Visualization. * [pheatmap](https://CRAN.R-project.org/package=pheatmap) - > Raivo Kolde (2018). pheatmap: Pretty Heatmaps. + > Raivo Kolde (2018). pheatmap: Pretty Heatmaps. * [lattice](https://cran.r-project.org/web/packages/lattice/index.html) - > Sarkar, Deepayan (2008) Lattice: Multivariate Data Visualization with R. Springer, New York. ISBN 978-0-387-75968-5. + > Sarkar, Deepayan (2008) Lattice: Multivariate Data Visualization with R. Springer, New York. ISBN 978-0-387-75968-5. * [RColorBrewer](https://CRAN.R-project.org/package=RColorBrewer) - > Erich Neuwirth (2014). RColorBrewer: ColorBrewer Palettes. + > Erich Neuwirth (2014). RColorBrewer: ColorBrewer Palettes. * [optparse](https://CRAN.R-project.org/package=optparse) - > Trevor L Davis (2018). optparse: Command Line Option Parser. + > Trevor L Davis (2018). optparse: Command Line Option Parser. * [xfun](https://CRAN.R-project.org/package=xfun) - > Yihui Xie (2018). xfun: Miscellaneous Functions by 'Yihui Xie'. + > Yihui Xie (2018). xfun: Miscellaneous Functions by 'Yihui Xie'. ## Software packaging/containerisation tools diff --git a/assets/bamtools_filter_pe.json b/assets/bamtools_filter_pe.json index 323c186c0..b69b41ba5 100755 --- a/assets/bamtools_filter_pe.json +++ b/assets/bamtools_filter_pe.json @@ -1,15 +1,15 @@ { "filters" : [ { "id" : "insert_min", - "insertSize" : ">=-2000" + "insertSize" : ">=-2000" }, { "id" : "insert_max", - "insertSize" : "<=2000" + "insertSize" : "<=2000" }, { "id" : "mismatch", - "tag" : "NM:<=4" + "tag" : "NM:<=4" } ], diff --git a/assets/bamtools_filter_se.json b/assets/bamtools_filter_se.json index 0b21d3e97..f62800e7f 100755 --- a/assets/bamtools_filter_se.json +++ b/assets/bamtools_filter_se.json @@ -1,7 +1,7 @@ { "filters" : [ { "id" : "mismatch", - "tag" : "NM:<=4" + "tag" : "NM:<=4" } ], diff --git a/bin/featurecounts_deseq2.r b/bin/featurecounts_deseq2.r index b75335a5b..32ba77dc7 100755 --- a/bin/featurecounts_deseq2.r +++ b/bin/featurecounts_deseq2.r @@ -116,9 +116,9 @@ if (file.exists(PlotFile) == FALSE) { xlab(paste0("PC1: ",percentVar[1],"% variance")) + ylab(paste0("PC2: ",percentVar[2],"% variance")) + theme(panel.grid.major = element_blank(), - panel.grid.minor = element_blank(), - panel.background = element_blank(), - panel.border = element_rect(colour = "black", fill=NA, size=1)) + panel.grid.minor = element_blank(), + panel.background = element_blank(), + panel.border = element_rect(colour = "black", fill=NA, size=1)) print(plot) ## WRITE PC1 vs PC2 VALUES TO FILE @@ -262,11 +262,11 @@ if (file.exists(ResultsFile) == FALSE) { clabels <- sapply(combs,function(x){paste(x,collapse=' & ')}) plotdat <- data.frame(x=unlist(lapply(combs, function(x){rld.subset[, x[1] ]})),y=unlist(lapply(combs, function(y){rld.subset[, y[2] ]})),comp=rep(clabels, each=nrow(rld.subset))) plot <- xyplot(y~x|comp,plotdat, - panel=function(...){ - panel.xyplot(...) - panel.abline(0,1,col="red") - }, - par.strip.text=list(cex=0.5)) + panel=function(...){ + panel.xyplot(...) + panel.abline(0,1,col="red") + }, + par.strip.text=list(cex=0.5)) print(plot) dev.off() diff --git a/bin/gtf2bed b/bin/gtf2bed index e6904926d..66d523067 100755 --- a/bin/gtf2bed +++ b/bin/gtf2bed @@ -33,90 +33,90 @@ my $in_cmd =($in =~ /\.gz$/ ? "gunzip -c $in|" : $in =~ /\.zip$/ ? "unzip -p $in open IN, $in_cmd; while () { - $gff = 2 if /^##gff-version 2/; - $gff = 3 if /^##gff-version 3/; - next if /^#/ && $gff; - - s/\s+$//; - # 0-chr 1-src 2-feat 3-beg 4-end 5-scor 6-dir 7-fram 8-attr - my @f = split /\t/; - if ($gff) { + $gff = 2 if /^##gff-version 2/; + $gff = 3 if /^##gff-version 3/; + next if /^#/ && $gff; + + s/\s+$//; + # 0-chr 1-src 2-feat 3-beg 4-end 5-scor 6-dir 7-fram 8-attr + my @f = split /\t/; + if ($gff) { # most ver 2's stick gene names in the id field - ($id) = $f[8]=~ /\bID="([^"]+)"/; + ($id) = $f[8]=~ /\bID="([^"]+)"/; # most ver 3's stick unquoted names in the name field - ($id) = $f[8]=~ /\bName=([^";]+)/ if !$id && $gff == 3; - } else { - ($id) = $f[8]=~ /transcript_id "([^"]+)"/; - } + ($id) = $f[8]=~ /\bName=([^";]+)/ if !$id && $gff == 3; + } else { + ($id) = $f[8]=~ /transcript_id "([^"]+)"/; + } - next unless $id && $f[0]; + next unless $id && $f[0]; - if ($f[2] eq 'exon') { - die "no position at exon on line $." if ! $f[3]; + if ($f[2] eq 'exon') { + die "no position at exon on line $." if ! $f[3]; # gff3 puts :\d in exons sometimes $id =~ s/:\d+$// if $gff == 3; - push @{$exons{$id}}, \@f; - # save lowest start - $trans{$id} = \@f if !$trans{$id}; - } elsif ($f[2] eq 'start_codon') { - #optional, output codon start/stop as "thick" region in bed - $sc{$id}->[0] = $f[3]; - } elsif ($f[2] eq 'stop_codon') { - $sc{$id}->[1] = $f[4]; - } elsif ($f[2] eq 'miRNA' ) { - $trans{$id} = \@f if !$trans{$id}; - push @{$exons{$id}}, \@f; - } + push @{$exons{$id}}, \@f; + # save lowest start + $trans{$id} = \@f if !$trans{$id}; + } elsif ($f[2] eq 'start_codon') { + #optional, output codon start/stop as "thick" region in bed + $sc{$id}->[0] = $f[3]; + } elsif ($f[2] eq 'stop_codon') { + $sc{$id}->[1] = $f[4]; + } elsif ($f[2] eq 'miRNA' ) { + $trans{$id} = \@f if !$trans{$id}; + push @{$exons{$id}}, \@f; + } } for $id ( - # sort by chr then pos - sort { - $trans{$a}->[0] eq $trans{$b}->[0] ? - $trans{$a}->[3] <=> $trans{$b}->[3] : - $trans{$a}->[0] cmp $trans{$b}->[0] - } (keys(%trans)) ) { - my ($chr, undef, undef, undef, undef, undef, $dir, undef, $attr, undef, $cds, $cde) = @{$trans{$id}}; + # sort by chr then pos + sort { + $trans{$a}->[0] eq $trans{$b}->[0] ? + $trans{$a}->[3] <=> $trans{$b}->[3] : + $trans{$a}->[0] cmp $trans{$b}->[0] + } (keys(%trans)) ) { + my ($chr, undef, undef, undef, undef, undef, $dir, undef, $attr, undef, $cds, $cde) = @{$trans{$id}}; my ($cds, $cde); ($cds, $cde) = @{$sc{$id}} if $sc{$id}; - # sort by pos - my @ex = sort { - $a->[3] <=> $b->[3] - } @{$exons{$id}}; - - my $beg = $ex[0][3]; - my $end = $ex[-1][4]; - - if ($dir eq '-') { - # swap - $tmp=$cds; - $cds=$cde; - $cde=$tmp; - $cds -= 2 if $cds; - $cde += 2 if $cde; - } + # sort by pos + my @ex = sort { + $a->[3] <=> $b->[3] + } @{$exons{$id}}; + + my $beg = $ex[0][3]; + my $end = $ex[-1][4]; + + if ($dir eq '-') { + # swap + $tmp=$cds; + $cds=$cde; + $cde=$tmp; + $cds -= 2 if $cds; + $cde += 2 if $cde; + } - # not specified, just use exons - $cds = $beg if !$cds; - $cde = $end if !$cde; + # not specified, just use exons + $cds = $beg if !$cds; + $cde = $end if !$cde; - # adjust start for bed - --$beg; --$cds; + # adjust start for bed + --$beg; --$cds; - my $exn = @ex; # exon count - my $exst = join ",", map {$_->[3]-$beg-1} @ex; # exon start - my $exsz = join ",", map {$_->[4]-$_->[3]+1} @ex; # exon size + my $exn = @ex; # exon count + my $exst = join ",", map {$_->[3]-$beg-1} @ex; # exon start + my $exsz = join ",", map {$_->[4]-$_->[3]+1} @ex; # exon size my $gene_id; my $extend = ""; if ($extended) { - ($gene_id) = $attr =~ /gene_name "([^"]+)"/; - ($gene_id) = $attr =~ /gene_id "([^"]+)"/ unless $gene_id; + ($gene_id) = $attr =~ /gene_name "([^"]+)"/; + ($gene_id) = $attr =~ /gene_id "([^"]+)"/ unless $gene_id; $extend="\t$gene_id"; } - # added an extra comma to make it look exactly like ucsc's beds - print "$chr\t$beg\t$end\t$id\t0\t$dir\t$cds\t$cde\t0\t$exn\t$exsz,\t$exst,$extend\n"; + # added an extra comma to make it look exactly like ucsc's beds + print "$chr\t$beg\t$end\t$id\t0\t$dir\t$cds\t$cde\t0\t$exn\t$exsz,\t$exst,$extend\n"; } diff --git a/bin/markdown_to_html.py b/bin/markdown_to_html.py index a26d1ff5e..1187b2720 100755 --- a/bin/markdown_to_html.py +++ b/bin/markdown_to_html.py @@ -27,33 +27,33 @@ def wrap_html(contents): + + + + + + + + + ''' + ) + ] + for process, tmp_versions in sorted(versions.items()): + html.append("") + for i, (tool, version) in enumerate(sorted(tmp_versions.items())): + html.append( + dedent( + f'''\\ + + + + + + ''' + ) + ) + html.append("") + html.append("
Process Name Software Version
{process if (i == 0) else ''}{tool}{version}
") + return "\\n".join(html) + + module_versions = {} + module_versions["${getProcessName(task.process)}"] = { + 'python': platform.python_version(), + 'yaml': yaml.__version__ + } + + with open("$versions") as f: + workflow_versions = yaml.safe_load(f) | module_versions + + workflow_versions["Workflow"] = { + "Nextflow": "$workflow.nextflow.version", + "$workflow.manifest.name": "$workflow.manifest.version" + } + + versions_mqc = { + 'id': 'software_versions', + 'section_name': '${workflow.manifest.name} Software Versions', + 'section_href': 'https://github.com/${workflow.manifest.name}', + 'plot_type': 'html', + 'description': 'are collected at run time from the software output.', + 'data': _make_versions_html(workflow_versions) + } + + with open("software_versions.yml", 'w') as f: + yaml.dump(workflow_versions, f, default_flow_style=False) + with open("software_versions_mqc.yml", 'w') as f: + yaml.dump(versions_mqc, f, default_flow_style=False) + + with open('versions.yml', 'w') as f: + yaml.dump(module_versions, f, default_flow_style=False) + """ +} diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml b/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml new file mode 100644 index 000000000..8d4a6ed42 --- /dev/null +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml @@ -0,0 +1,33 @@ +name: custom_dumpsoftwareversions +description: Custom module used to dump software versions within the nf-core pipeline template +keywords: + - custom + - version +tools: + - custom: + description: Custom module used to dump software versions within the nf-core pipeline template + homepage: https://github.com/nf-core/tools + documentation: https://github.com/nf-core/tools + +input: + - versions: + type: file + description: YML file containing software versions + pattern: "*.yml" + +output: + - yml: + type: file + description: Standard YML file containing software versions + pattern: "software_versions.yml" + - mqc_yml: + type: file + description: MultiQC custom content YML file containing software versions + pattern: "software_versions_mqc.yml" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" + +authors: + - "@drpatelh" diff --git a/subworkflows/local/bam_clean.nf b/subworkflows/local/bam_clean.nf index 68e35a63b..d53912588 100644 --- a/subworkflows/local/bam_clean.nf +++ b/subworkflows/local/bam_clean.nf @@ -19,16 +19,24 @@ workflow BAM_CLEAN { bamtools_filter_pe_config // file: BAMtools filter JSON config file for PE data main: + + ch_versions = Channel.empty() + BAM_FILTER(ch_bam_bai, ch_bed, bamtools_filter_se_config, bamtools_filter_pe_config) BAM_REMOVE_ORPHANS(BAM_FILTER.out.bam) BAM_SORT_SAMTOOLS(BAM_REMOVE_ORPHANS.out.bam) + ch_versions = ch_versions.mix(BAM_FILTER.out.versions, + BAM_REMOVE_ORPHANS.out.versions, + BAM_SORT_SAMTOOLS.out.versions) + emit: - name_bam = BAM_REMOVE_ORPHANS.out.bam // channel: [ val(meta), [ bam ] ] - bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] - bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] - stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - bamtools_version = BAM_FILTER.out.version // path: versions.yml + name_bam = BAM_REMOVE_ORPHANS.out.bam // channel: [ val(meta), [ bam ] ] + bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] + bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + + versions = ch_versions // channel: [ versions.yml ] } diff --git a/subworkflows/nf-core/bam_sort_samtools.nf b/subworkflows/nf-core/bam_sort_samtools.nf index c524ac321..e7652259a 100644 --- a/subworkflows/nf-core/bam_sort_samtools.nf +++ b/subworkflows/nf-core/bam_sort_samtools.nf @@ -15,15 +15,23 @@ workflow BAM_SORT_SAMTOOLS { ch_bam // channel: [ val(meta), [ bam ] ] main: + + ch_versions = Channel.empty() + SAMTOOLS_SORT(ch_bam) SAMTOOLS_INDEX(SAMTOOLS_SORT.out.bam) BAM_STATS_SAMTOOLS(SAMTOOLS_SORT.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0])) + ch_versions = ch_versions.mix(SAMTOOLS_SORT.out.versions.first(), + SAMTOOLS_INDEX.out.versions.first(), + BAM_STATS_SAMTOOLS.out.versions) + emit: bam = SAMTOOLS_SORT.out.bam // channel: [ val(meta), [ bam ] ] bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] stats = BAM_STATS_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] flagstat = BAM_STATS_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] idxstats = BAM_STATS_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - samtools_versions = SAMTOOLS_SORT.out.versions // path: versions.yml + + versions = ch_versions // channel: [ versions.yml ] } diff --git a/subworkflows/nf-core/bam_stats_samtools.nf b/subworkflows/nf-core/bam_stats_samtools.nf index 919ab5b24..013ffac9e 100644 --- a/subworkflows/nf-core/bam_stats_samtools.nf +++ b/subworkflows/nf-core/bam_stats_samtools.nf @@ -13,13 +13,21 @@ workflow BAM_STATS_SAMTOOLS { ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] main: + + ch_versions = Channel.empty() + SAMTOOLS_STATS(ch_bam_bai) SAMTOOLS_FLAGSTAT(ch_bam_bai) SAMTOOLS_IDXSTATS(ch_bam_bai) + ch_versions = ch_versions.mix(SAMTOOLS_STATS.out.versions.first(), + SAMTOOLS_FLAGSTAT.out.versions.first(), + SAMTOOLS_IDXSTATS.out.versions.first()) + emit: stats = SAMTOOLS_STATS.out.stats // channel: [ val(meta), [ stats ] ] flagstat = SAMTOOLS_FLAGSTAT.out.flagstat // channel: [ val(meta), [ flagstat ] ] idxstats = SAMTOOLS_IDXSTATS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - samtools_versions = SAMTOOLS_STATS.out.versions // path: versions.yml + + versions = ch_versions // channel: [ versions.yml ] } diff --git a/subworkflows/nf-core/fastqc_trimgalore.nf b/subworkflows/nf-core/fastqc_trimgalore.nf index 2cb1cc7eb..0636f0a55 100644 --- a/subworkflows/nf-core/fastqc_trimgalore.nf +++ b/subworkflows/nf-core/fastqc_trimgalore.nf @@ -16,36 +16,37 @@ workflow FASTQC_TRIMGALORE { skip_trimming // boolean: true/false main: - fastqc_html = Channel.empty() - fastqc_zip = Channel.empty() - fastqc_version = Channel.empty() + + ch_versions = Channel.empty() + fastqc_html = Channel.empty() + fastqc_zip = Channel.empty() if (!skip_fastqc) { FASTQC(ch_reads).html.set { fastqc_html } fastqc_zip = FASTQC.out.zip - fastqc_versions = FASTQC.out.versions } - ch_trim_reads = ch_reads - trim_html = Channel.empty() - trim_zip = Channel.empty() - trim_log = Channel.empty() - trimgalore_version = Channel.empty() + ch_trim_reads = ch_reads + trim_html = Channel.empty() + trim_zip = Channel.empty() + trim_log = Channel.empty() if (!skip_trimming) { TRIMGALORE(ch_reads).reads.set { ch_trim_reads } trim_html = TRIMGALORE.out.html trim_zip = TRIMGALORE.out.zip trim_log = TRIMGALORE.out.log - trimgalore_versions = TRIMGALORE.out.versions } + ch_versions = ch_versions.mix(FASTQC.out.versions.first(), + TRIMGALORE.out.versions.first()) + emit: - fastqc_html // channel: [ val(meta), [ html ] ] - fastqc_zip // channel: [ val(meta), [ zip ] ] - fastqc_version // path: versions.yml - - reads = ch_trim_reads // channel: [ val(meta), [ reads ] ] - trim_html // channel: [ val(meta), [ html ] ] - trim_zip // channel: [ val(meta), [ zip ] ] - trim_log // channel: [ val(meta), [ txt ] ] - trimgalore_version // path: versions.yml + fastqc_html // channel: [ val(meta), [ html ] ] + fastqc_zip // channel: [ val(meta), [ zip ] ] + + reads = ch_trim_reads // channel: [ val(meta), [ reads ] ] + trim_html // channel: [ val(meta), [ html ] ] + trim_zip // channel: [ val(meta), [ zip ] ] + trim_log // channel: [ val(meta), [ txt ] ] + + versions = ch_versions // path: versions.yml } diff --git a/subworkflows/nf-core/map_bwa_mem.nf b/subworkflows/nf-core/map_bwa_mem.nf index 079c2651e..8ce4cf9c1 100644 --- a/subworkflows/nf-core/map_bwa_mem.nf +++ b/subworkflows/nf-core/map_bwa_mem.nf @@ -16,15 +16,21 @@ workflow MAP_BWA_MEM { ch_index // path: /path/to/index main: + + ch_versions = Channel.empty() + BWA_MEM(ch_reads, ch_index) BAM_SORT_SAMTOOLS(BWA_MEM.out.bam) + ch_versions = ch_versions.mix(BWA_MEM.out.versions.first(), + BAM_SORT_SAMTOOLS.out.versions) + emit: bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - bwa_versions = BWA_MEM.out.versions // path: versions.yml - samtools_versions = BAM_SORT_SAMTOOLS.out.samtools_versions // path: versions.yml + + versions = ch_versions // path: versions.yml } diff --git a/subworkflows/nf-core/mark_duplicates_picard.nf b/subworkflows/nf-core/mark_duplicates_picard.nf index 06cc40ea9..9f8e53608 100644 --- a/subworkflows/nf-core/mark_duplicates_picard.nf +++ b/subworkflows/nf-core/mark_duplicates_picard.nf @@ -14,10 +14,17 @@ workflow MARK_DUPLICATES_PICARD { ch_bam // channel: [ val(meta), [ bam ] ] main: + + ch_versions = Channel.empty() + PICARD_MARKDUPLICATES(ch_bam) SAMTOOLS_INDEX(PICARD_MARKDUPLICATES.out.bam) BAM_STATS_SAMTOOLS(PICARD_MARKDUPLICATES.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0])) + ch_versions = ch_versions.mix(PICARD_MARKDUPLICATES.out.versions.first(), + SAMTOOLS_INDEX.out.versions.first(), + BAM_STATS_SAMTOOLS.out.versions) + emit: bam = PICARD_MARKDUPLICATES.out.bam // channel: [ val(meta), [ bam ] ] metrics = PICARD_MARKDUPLICATES.out.metrics // channel: [ val(meta), [ metrics ] ] @@ -25,6 +32,6 @@ workflow MARK_DUPLICATES_PICARD { stats = BAM_STATS_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] flagstat = BAM_STATS_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] idxstats = BAM_STATS_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - picard_versions = PICARD_MARKDUPLICATES.out.versions // path: versions.yml - samtools_versions = SAMTOOLS_INDEX.out.versions // path: versions.yml + + versions = ch_versions // path: versions.yml } diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 151a4dde9..05d242c0f 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -118,7 +118,7 @@ include { FRIP_SCORE } from '../modules/local/frip_scor //include { DESEQ2_FEATURECOUNTS } from '../modules/local/deseq2_featurecounts' addParams( options: [:] ) include { IGV } from '../modules/local/igv' addParams( options: [:] ) include { OUTPUT_DOCUMENTATION } from '../modules/local/output_documentation' addParams( options: [:] ) -include { GET_SOFTWARE_VERSIONS } from '../modules/local/get_software_versions' addParams( options: modules['get_software_versions'] ) +// include { GET_SOFTWARE_VERSIONS } from '../modules/local/get_software_versions' addParams( options: modules['get_software_versions'] ) // TODO template version below to be removed when checked // include { GET_SOFTWARE_VERSIONS } from '../modules/local/get_software_versions' addParams( options: [publish_files : ['tsv':'']] ) include { MULTIQC } from '../modules/local/multiqc' addParams( options: multiqc_options ) @@ -176,6 +176,8 @@ include { DEEPTOOLS_PLOTFINGERPRINT } from '../modules/nf-core/modules/deept include { PHANTOMPEAKQUALTOOLS } from '../modules/nf-core/modules/phantompeakqualtools/main' addParams( options: modules['phantompeakqualtools'] ) include { MACS2_CALLPEAK } from '../modules/nf-core/modules/macs2/callpeak/main' addParams( options: macs2_callpeak_options ) include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/modules/subread/featurecounts/main' addParams( options: subread_featurecounts_options ) +include { CUSTOM_DUMPSOFTWAREVERSIONS } from '../modules/nf-core/modules/custom/dumpsoftwareversions/main' addParams( options: [publish_files : ['_versions.yml':'']] ) + include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_macs2_options ) include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_consensus_options ) @@ -197,7 +199,7 @@ def multiqc_report = [] workflow CHIPSEQ { - ch_software_versions = Channel.empty() + ch_versions = Channel.empty() // // SUBWORKFLOW: Read in samplesheet, validate and stage input files @@ -228,8 +230,9 @@ workflow CHIPSEQ { GET_CHROM_SIZES ( ch_fasta ).sizes, ch_blacklist.ifEmpty([]) ) - ch_software_versions = Channel.empty() - ch_software_versions = ch_software_versions.mix(MAKE_GENOME_FILTER.out.versions.first().ifEmpty(null)) + // ch_software_versions = Channel.empty() + // ch_software_versions = ch_software_versions.mix(MAKE_GENOME_FILTER.out.versions.first().ifEmpty(null)) + ch_versions = ch_versions.mix(MAKE_GENOME_FILTER.out.versions) // // SUBWORKFLOW: Read QC & trimming @@ -241,8 +244,8 @@ workflow CHIPSEQ { params.skip_fastqc, params.skip_trimming ) - ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.fastqc_version.first().ifEmpty(null)) - ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.trimgalore_version.first().ifEmpty(null)) + // ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.fastqc_versions.first().ifEmpty(null)) + ch_versions = ch_versions.mix(FASTQC_TRIMGALORE.out.versions) // // SUBWORKFLOW: Map reads & BAM QC @@ -253,8 +256,9 @@ workflow CHIPSEQ { FASTQC_TRIMGALORE.out.reads, ch_index ) - ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.bwa_versions.first()) - ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.samtools_versions.first().ifEmpty(null)) + // ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.bwa_versions.first()) + // ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.samtools_versions.first().ifEmpty(null)) + ch_versions = ch_versions.mix(MAP_BWA_MEM.out.versions) // // SUBWORKFLOW: Merge resequenced BAM files @@ -274,7 +278,8 @@ workflow CHIPSEQ { PICARD_MERGESAMFILES ( ch_sort_bam ) - ch_software_versions = ch_software_versions.mix(PICARD_MERGESAMFILES.out.versions.first().ifEmpty(null)) + // ch_software_versions = ch_software_versions.mix(PICARD_MERGESAMFILES.out.versions.first().ifEmpty(null)) + ch_versions = ch_versions.mix(PICARD_MERGESAMFILES.out.versions) // // SUBWORKFLOW: Mark duplicates & filter BAM files @@ -292,7 +297,8 @@ workflow CHIPSEQ { ch_bamtools_filter_se_config, ch_bamtools_filter_pe_config ) - ch_software_versions = ch_software_versions.mix(BAM_CLEAN.out.bamtools_version.first().ifEmpty(null)) + // ch_software_versions = ch_software_versions.mix(BAM_CLEAN.out.bamtools_versions.first().ifEmpty(null)) + ch_versions = ch_versions.mix(BAM_CLEAN.out.versions) // // MODULE: Post alignment QC @@ -302,13 +308,16 @@ workflow CHIPSEQ { ch_fasta ) + // TODO Add versions to picard collectmultiplemetrics + // // MODULE: Library coverage // PRESEQ_LCEXTRAP ( BAM_CLEAN.out.bam ) - ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.versions.first().ifEmpty(null)) + // ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.versions.first().ifEmpty(null)) + ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions) // // MODULE: Strand cross-correlation @@ -316,7 +325,8 @@ workflow CHIPSEQ { PHANTOMPEAKQUALTOOLS ( BAM_CLEAN.out.bam ) - ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions.first().ifEmpty(null)) + // ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions.first().ifEmpty(null)) + ch_versions = ch_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions) MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( PHANTOMPEAKQUALTOOLS.out.spp.join(PHANTOMPEAKQUALTOOLS.out.rdata, by: [0]), @@ -339,7 +349,8 @@ workflow CHIPSEQ { BEDTOOLS_GENOMECOV.out.bedgraph, GET_CHROM_SIZES.out.sizes ) - ch_software_versions = ch_software_versions.mix(UCSC_BEDGRAPHTOBIGWIG.out.versions.first().ifEmpty(null)) + // ch_software_versions = ch_software_versions.mix(UCSC_BEDGRAPHTOBIGWIG.out.versions.first().ifEmpty(null)) + ch_versions = ch_versions.mix(UCSC_BEDGRAPHTOBIGWIG.out.versions) // // MODULE: Coverage plots @@ -348,7 +359,8 @@ workflow CHIPSEQ { UCSC_BEDGRAPHTOBIGWIG.out.bigwig, ch_gene_bed ) - ch_software_versions = ch_software_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first().ifEmpty(null)) + // ch_software_versions = ch_software_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first().ifEmpty(null)) + ch_versions = ch_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions) DEEPTOOLS_PLOTPROFILE ( DEEPTOOLS_COMPUTEMATRIX.out.matrix @@ -399,7 +411,8 @@ workflow CHIPSEQ { ch_ip_control_bam, params.macs_gsize ) - ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.versions.first().ifEmpty(null)) + // ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.versions.first().ifEmpty(null)) + ch_versions = ch_versions.mix(MACS2_CALLPEAK.out.versions) ch_ip_control_bam .join(MACS2_CALLPEAK.out.peak, by: [0]) @@ -428,7 +441,8 @@ workflow CHIPSEQ { ch_fasta, ch_gtf ) - ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first().ifEmpty(null)) + // ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first().ifEmpty(null)) + ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions) PLOT_HOMER_ANNOTATEPEAKS ( HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, @@ -492,7 +506,8 @@ workflow CHIPSEQ { SUBREAD_FEATURECOUNTS ( ch_ip_bam ) - ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first().ifEmpty(null)) + // ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first().ifEmpty(null)) + ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions) // // DESEQ2_FEATURECOUNTS ( @@ -519,19 +534,23 @@ workflow CHIPSEQ { // // MODULE: Pipeline reporting // - ch_software_versions - .map { it -> if (it) [ it.baseName, it ] } - .groupTuple() - .map { it[1][0] } - .flatten() - .collect() - .set { ch_software_versions } - - GET_SOFTWARE_VERSIONS ( - ch_software_versions.map { it }.collect() //, - // params.modules['get_software_versions'] // TODO check if its needed, I think that addParams does the trick + // ch_software_versions + // .map { it -> if (it) [ it.baseName, it ] } + // .groupTuple() + // .map { it[1][0] } + // .flatten() + // .collect() + // .set { ch_software_versions } + + // GET_SOFTWARE_VERSIONS ( + // ch_software_versions.map { it }.collect() //, + // // params.modules['get_software_versions'] // TODO check if its needed, I think that addParams does the trick + // ) + CUSTOM_DUMPSOFTWAREVERSIONS ( + ch_versions.unique().collectFile() ) + OUTPUT_DOCUMENTATION ( ch_output_docs, ch_output_docs_images @@ -554,7 +573,7 @@ workflow CHIPSEQ { MULTIQC ( ch_multiqc_config, ch_multiqc_custom_config.collect().ifEmpty([]), - GET_SOFTWARE_VERSIONS.out.yaml.collect(), + CUSTOM_DUMPSOFTWAREVERSIONS.out.mqc_yml.collect(), ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml'), FASTQC_TRIMGALORE.out.fastqc_zip.collect{it[1]}.ifEmpty([]), From 65ad7b67e5852e6f524345883bf0e044a0a23cc3 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 5 Oct 2021 12:39:40 +0200 Subject: [PATCH 201/538] Fix fastqc_trimgalore --- subworkflows/nf-core/fastqc_trimgalore.nf | 5 ++--- 1 file changed, 2 insertions(+), 3 deletions(-) diff --git a/subworkflows/nf-core/fastqc_trimgalore.nf b/subworkflows/nf-core/fastqc_trimgalore.nf index 0636f0a55..f0638abcb 100644 --- a/subworkflows/nf-core/fastqc_trimgalore.nf +++ b/subworkflows/nf-core/fastqc_trimgalore.nf @@ -23,6 +23,7 @@ workflow FASTQC_TRIMGALORE { if (!skip_fastqc) { FASTQC(ch_reads).html.set { fastqc_html } fastqc_zip = FASTQC.out.zip + ch_versions = ch_versions.mix(FASTQC.out.versions.first()) } ch_trim_reads = ch_reads @@ -34,11 +35,9 @@ workflow FASTQC_TRIMGALORE { trim_html = TRIMGALORE.out.html trim_zip = TRIMGALORE.out.zip trim_log = TRIMGALORE.out.log + ch_versions = ch_versions.mix(TRIMGALORE.out.versions.first()) } - ch_versions = ch_versions.mix(FASTQC.out.versions.first(), - TRIMGALORE.out.versions.first()) - emit: fastqc_html // channel: [ val(meta), [ html ] ] fastqc_zip // channel: [ val(meta), [ zip ] ] From f202fc0b41f2042d6e0c9ff3d94254cc427175bd Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 5 Oct 2021 22:35:00 +0200 Subject: [PATCH 202/538] Fix nf-core lint --- .nf-core.yml | 7 +++++++ bin/scrape_software_versions.py | 36 --------------------------------- 2 files changed, 7 insertions(+), 36 deletions(-) delete mode 100755 bin/scrape_software_versions.py diff --git a/.nf-core.yml b/.nf-core.yml index 5ed024fdf..c8445e750 100644 --- a/.nf-core.yml +++ b/.nf-core.yml @@ -1,4 +1,11 @@ lint: files_unchanged: + - .markdownlint.yml + - assets/email_template.html + - assets/email_template.txt + - lib/NfcoreTemplate.groovy - assets/multiqc_config.yaml actions_ci: False #get rid of the error "CI is not building the correct docker image. Should be: docker build..." + files_exist: + - bin/scrape_software_versions.py + - modules/local/get_software_versions.nf diff --git a/bin/scrape_software_versions.py b/bin/scrape_software_versions.py deleted file mode 100755 index c060d8d5d..000000000 --- a/bin/scrape_software_versions.py +++ /dev/null @@ -1,36 +0,0 @@ -#!/usr/bin/env python -from __future__ import print_function -import os - -results = {} -version_files = [x for x in os.listdir(".") if x.endswith(".version.txt")] -for version_file in version_files: - - software = version_file.replace(".version.txt", "") - if software == "pipeline": - software = "nf-core/chipseq" - - with open(version_file) as fin: - version = fin.read().strip() - results[software] = version - -# Dump to YAML -print( - """ -id: 'software_versions' -section_name: 'nf-core/chipseq Software Versions' -section_href: 'https://github.com/nf-core/chipseq' -plot_type: 'html' -description: 'are collected at run time from the software output.' -data: | -

-""" -) -for k, v in sorted(results.items()): - print("
{}
{}
".format(k, v)) -print("
") - -# Write out as tsv file: -with open("software_versions.tsv", "w") as f: - for k, v in sorted(results.items()): - f.write("{}\t{}\n".format(k, v)) From 2f3a0b3c638bb3c67c5d0a8cfa213284ba2b712d Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 5 Oct 2021 22:35:23 +0200 Subject: [PATCH 203/538] Fix module import --- modules/local/multiqc_custom_phantompeakqualtools.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/modules/local/multiqc_custom_phantompeakqualtools.nf b/modules/local/multiqc_custom_phantompeakqualtools.nf index de88fbe49..a62557e2f 100644 --- a/modules/local/multiqc_custom_phantompeakqualtools.nf +++ b/modules/local/multiqc_custom_phantompeakqualtools.nf @@ -1,5 +1,5 @@ // Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' +include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' params.options = [:] options = initOptions(params.options) From 41e97e4440380df546cb5e8b6f3edd45cd6d8803 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 6 Oct 2021 08:23:00 +0200 Subject: [PATCH 204/538] Update python shebang to python3 --- CHANGELOG.md | 1 + bin/bampe_rm_orphan.py | 2 +- bin/check_samplesheet.py | 2 +- bin/igv_files_to_session.py | 2 +- bin/macs2_merged_expand.py | 2 +- bin/markdown_to_html.py | 3 ++- 6 files changed, 7 insertions(+), 5 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index ed8227cdb..c97a823ce 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -10,6 +10,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 * Pipeline has been re-implemented in [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) * Updated Nextflow version to `v21.04.0` (see [nextflow#572](https://github.com/nextflow-io/nextflow/issues/1964)) * Move template boilerplate code to Groovy `lib/` +* Added `python3` shebang to appropriate scripts in `bin/` directory ### Other enhancements & fixes diff --git a/bin/bampe_rm_orphan.py b/bin/bampe_rm_orphan.py index 5b0a6f729..5de45ea65 100755 --- a/bin/bampe_rm_orphan.py +++ b/bin/bampe_rm_orphan.py @@ -1,4 +1,4 @@ -#!/usr/bin/env python +#!/usr/bin/env python3 ############################################################################### ############################################################################### diff --git a/bin/check_samplesheet.py b/bin/check_samplesheet.py index 79b36ba52..fdbee3889 100755 --- a/bin/check_samplesheet.py +++ b/bin/check_samplesheet.py @@ -1,4 +1,4 @@ -#!/usr/bin/env python +#!/usr/bin/env python3 import os import sys diff --git a/bin/igv_files_to_session.py b/bin/igv_files_to_session.py index 48e749c8e..adfe8f7e2 100755 --- a/bin/igv_files_to_session.py +++ b/bin/igv_files_to_session.py @@ -1,4 +1,4 @@ -#!/usr/bin/env python +#!/usr/bin/env python3 ####################################################################### ####################################################################### diff --git a/bin/macs2_merged_expand.py b/bin/macs2_merged_expand.py index f4e84a14d..0aa184757 100755 --- a/bin/macs2_merged_expand.py +++ b/bin/macs2_merged_expand.py @@ -1,4 +1,4 @@ -#!/usr/bin/env python +#!/usr/bin/env python3 ####################################################################### ####################################################################### diff --git a/bin/markdown_to_html.py b/bin/markdown_to_html.py index 1187b2720..13350d440 100755 --- a/bin/markdown_to_html.py +++ b/bin/markdown_to_html.py @@ -1,4 +1,5 @@ -#!/usr/bin/env python +#!/usr/bin/env python3 + from __future__ import print_function import argparse import markdown From 23bdb0a4dcdef2415ac4cce362f4109c3c940624 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 6 Oct 2021 08:43:06 +0200 Subject: [PATCH 205/538] Update dumpsoftwareversions to report version trailing zeros --- modules.json | 2 +- modules/nf-core/modules/custom/dumpsoftwareversions/main.nf | 2 +- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/modules.json b/modules.json index 418a10605..832103e19 100644 --- a/modules.json +++ b/modules.json @@ -10,7 +10,7 @@ "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" }, "custom/dumpsoftwareversions": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "84f2302920078b0cf7716b2a2e5fcc0be5c4531d" }, "deeptools/computematrix": { "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf b/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf index cf10a8e07..faf2073f7 100644 --- a/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf @@ -79,7 +79,7 @@ process CUSTOM_DUMPSOFTWAREVERSIONS { } with open("$versions") as f: - workflow_versions = yaml.safe_load(f) | module_versions + workflow_versions = yaml.load(f, Loader=yaml.BaseLoader) | module_versions workflow_versions["Workflow"] = { "Nextflow": "$workflow.nextflow.version", From 909470e700c301942ab9516fe4f0b9d1e8a0e425 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Fri, 22 Oct 2021 18:03:51 +0100 Subject: [PATCH 206/538] First pass updates --- README.md | 15 +- assets/design_pe.csv | 21 -- assets/design_se.csv | 21 -- assets/multiqc/deseq2_clustering_header.txt | 6 +- assets/multiqc/deseq2_pca_header.txt | 4 +- assets/samplesheet.csv | 3 - assets/samplesheet_pe.csv | 21 ++ assets/samplesheet_se.csv | 21 ++ assets/schema_input.json | 10 + bin/check_samplesheet.py | 204 ++++++------- bin/check_samplesheet_old.py | 173 +++++++++++ bin/deseq2_qc.r | 247 ++++++++++++++++ bin/featurecounts_deseq2.r | 301 -------------------- bin/markdown_to_html.py | 92 ------ conf/modules.config | 10 +- conf/test_full.config | 0 docs/usage.md | 159 ++++------- lib/Completion.groovy | 117 -------- lib/Headers.groovy | 39 --- lib/Schema.groovy | 184 ------------ lib/WorkflowChipseq.groovy | 60 ++-- lib/WorkflowMain.groovy | 5 +- main.nf | 1 + nextflow.config | 53 ++-- nextflow_schema.json | 2 +- workflows/chipseq.nf | 46 +-- 26 files changed, 726 insertions(+), 1089 deletions(-) delete mode 100644 assets/design_pe.csv delete mode 100644 assets/design_se.csv delete mode 100644 assets/samplesheet.csv create mode 100644 assets/samplesheet_pe.csv create mode 100644 assets/samplesheet_se.csv create mode 100755 bin/check_samplesheet_old.py create mode 100755 bin/deseq2_qc.r delete mode 100755 bin/featurecounts_deseq2.r delete mode 100755 bin/markdown_to_html.py mode change 100755 => 100644 conf/test_full.config delete mode 100755 lib/Completion.groovy delete mode 100755 lib/Headers.groovy delete mode 100755 lib/Schema.groovy diff --git a/README.md b/README.md index bd992cd2b..5ab753299 100644 --- a/README.md +++ b/README.md @@ -18,10 +18,9 @@ **nfcore/chipseq** is a bioinformatics analysis pipeline used for Chromatin ImmunopreciPitation sequencing (ChIP-seq) data. -The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool to run tasks across multiple compute infrastructures in a very portable manner. It uses Docker/Singularity containers making installation trivial and results highly reproducible. The [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) implementation of this pipeline uses one container per process which makes it much easier to maintain and update software dependencies. Where possible, these processes have been submitted to and installed from [nf-core/modules](https://github.com/nf-core/modules) in order to make them available to all nf-core pipelines, and to everyone within the Nextflow community! +On release, automated continuous integration tests run the pipeline on a [full-sized dataset](https://github.com/nf-core/test-datasets/tree/chipseq#full-test-dataset-origin) obtained from the SRA on the AWS cloud infrastructure. This ensures that the pipeline runs on AWS, has sensible resource allocation defaults set to run on real-world datasets, and permits the persistent storage of results to benchmark between pipeline releases and other analysis sources. The results obtained from running the full-sized tests can be viewed on the [nf-core website](https://nf-co.re/chipseq/results). - -On release, automated continuous integration tests run the pipeline on a full-sized dataset on the AWS cloud infrastructure. This ensures that the pipeline runs on AWS, has sensible resource allocation defaults set to run on real-world datasets, and permits the persistent storage of results to benchmark between pipeline releases and other analysis sources. The results obtained from the full-sized test can be viewed on the [nf-core website](https://nf-co.re/chipseq/results). +The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool to run tasks across multiple compute infrastructures in a very portable manner. It uses Docker/Singularity containers making installation trivial and results highly reproducible. The [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) implementation of this pipeline uses one container per process which makes it much easier to maintain and update software dependencies. Where possible, these processes have been submitted to and installed from [nf-core/modules](https://github.com/nf-core/modules) in order to make them available to all nf-core pipelines, and to everyone within the Nextflow community! ## Pipeline summary @@ -74,7 +73,10 @@ On release, automated continuous integration tests run the pipeline on a full-si 4. Start running your own analysis! ```bash - nextflow run nf-core/chipseq -profile --input design.csv --genome GRCh37 + nextflow run nf-core/chipseq \ + --input samplsheet.csv \ + --genome GRCh37 \ + -profile ``` See [usage docs](https://nf-co.re/chipseq/usage) for all of the available options when running the pipeline. @@ -85,7 +87,7 @@ The nf-core/chipseq pipeline comes with documentation about the pipeline: [usage ## Credits -These scripts were originally written by Chuan Wang ([@chuan-wang](https://github.com/chuan-wang)) and Phil Ewels ([@ewels](https://github.com/ewels)) for use at the [National Genomics Infrastructure](https://portal.scilifelab.se/genomics/) at [SciLifeLab](http://www.scilifelab.se/) in Stockholm, Sweden. The pipeline has since been re-implemented by Harshil Patel ([@drpatelh](https://github.com/drpatelh)) from [The Bioinformatics & Biostatistics Group](https://www.crick.ac.uk/research/science-technology-platforms/bioinformatics-and-biostatistics/) at [The Francis Crick Institute](https://www.crick.ac.uk/), London. +These scripts were originally written by Chuan Wang ([@chuan-wang](https://github.com/chuan-wang)) and Phil Ewels ([@ewels](https://github.com/ewels)) for use at the [National Genomics Infrastructure](https://portal.scilifelab.se/genomics/) at [SciLifeLab](http://www.scilifelab.se/) in Stockholm, Sweden. The pipeline was re-implemented by Harshil Patel ([@drpatelh](https://github.com/drpatelh)) from [Seqera Labs, Spain](https://seqera.io/) and converted to Nextflow DSL2 by Jose Espinosa-Carrasco ([@JoseEspinosa](https://github.com/JoseEspinosa)) from [The Comparative Bioinformatics Group](https://www.crg.eu/en/cedric_notredame) at [The Centre for Genomic Regulation, Spain](https://www.crg.eu/). Many thanks to others who have helped out and contributed along the way too, including (but not limited to): [@apeltzer](https://github.com/apeltzer), [@bc2zb](https://github.com/bc2zb), [@crickbabs](https://github.com/crickbabs), [@drejom](https://github.com/drejom), [@houghtos](https://github.com/houghtos), [@KevinMenden](https://github.com/KevinMenden), [@mashehu](https://github.com/mashehu), [@pditommaso](https://github.com/pditommaso), [@Rotholandus](https://github.com/Rotholandus), [@sofiahaglund](https://github.com/sofiahaglund), [@tiagochst](https://github.com/tiagochst) and [@winni2k](https://github.com/winni2k). @@ -99,13 +101,10 @@ For further information or help, don't hesitate to get in touch on the [Slack `# If you use nf-core/chipseq for your analysis, please cite it using the following doi: [10.5281/zenodo.3240506](https://doi.org/10.5281/zenodo.3240506) - An extensive list of references for the tools used by the pipeline can be found in the [`CITATIONS.md`](CITATIONS.md) file. You can cite the `nf-core` publication as follows: -An extensive list of references for the tools used by the pipeline can be found in the [`CITATIONS.md`](CITATIONS.md) file. - > **The nf-core framework for community-curated bioinformatics pipelines.** > > Philip Ewels, Alexander Peltzer, Sven Fillinger, Harshil Patel, Johannes Alneberg, Andreas Wilm, Maxime Ulysse Garcia, Paolo Di Tommaso & Sven Nahnsen. diff --git a/assets/design_pe.csv b/assets/design_pe.csv deleted file mode 100644 index 6e6eae735..000000000 --- a/assets/design_pe.csv +++ /dev/null @@ -1,21 +0,0 @@ -group,replicate,fastq_1,fastq_2,antibody,control -WT_BCATENIN_IP,1,BLA203A1_S27_L006_R1_001.fastq.gz,BLA203A1_S27_L006_R2_001.fastq.gz,BCATENIN,WT_INPUT -WT_BCATENIN_IP,2,BLA203A25_S16_L001_R1_001.fastq.gz,BLA203A25_S16_L001_R2_001.fastq.gz,BCATENIN,WT_INPUT -WT_BCATENIN_IP,2,BLA203A25_S16_L002_R1_001.fastq.gz,BLA203A25_S16_L002_R2_001.fastq.gz,BCATENIN,WT_INPUT -WT_BCATENIN_IP,3,BLA203A49_S40_L001_R1_001.fastq.gz,BLA203A49_S40_L001_R2_001.fastq.gz,BCATENIN,WT_INPUT -NAIVE_BCATENIN_IP,1,BLA203A7_S60_L001_R1_001.fastq.gz,BLA203A7_S60_L001_R2_001.fastq.gz,BCATENIN,NAIVE_INPUT -NAIVE_BCATENIN_IP,2,BLA203A43_S34_L001_R1_001.fastq.gz,BLA203A43_S34_L001_R2_001.fastq.gz,BCATENIN,NAIVE_INPUT -NAIVE_BCATENIN_IP,2,BLA203A43_S34_L002_R1_001.fastq.gz,BLA203A43_S34_L002_R2_001.fastq.gz,BCATENIN,NAIVE_INPUT -NAIVE_BCATENIN_IP,3,BLA203A64_S55_L001_R1_001.fastq.gz,BLA203A64_S55_L001_R2_001.fastq.gz,BCATENIN,NAIVE_INPUT -WT_TCF4_IP,1,BLA203A3_S29_L006_R1_001.fastq.gz,BLA203A3_S29_L006_R2_001.fastq.gz,TCF4,WT_INPUT -WT_TCF4_IP,2,BLA203A27_S18_L001_R1_001.fastq.gz,BLA203A27_S18_L001_R2_001.fastq.gz,TCF4,WT_INPUT -WT_TCF4_IP,3,BLA203A51_S42_L001_R1_001.fastq.gz,BLA203A51_S42_L001_R2_001.fastq.gz,TCF4,WT_INPUT -NAIVE_TCF4_IP,1,BLA203A9_S62_L001_R1_001.fastq.gz,BLA203A9_S62_L001_R2_001.fastq.gz,TCF4,NAIVE_INPUT -NAIVE_TCF4_IP,2,BLA203A45_S36_L001_R1_001.fastq.gz,BLA203A45_S36_L001_R2_001.fastq.gz,TCF4,NAIVE_INPUT -NAIVE_TCF4_IP,3,BLA203A66_S57_L001_R1_001.fastq.gz,BLA203A66_S57_L001_R2_001.fastq.gz,TCF4,NAIVE_INPUT -WT_INPUT,1,BLA203A6_S32_L006_R1_001.fastq.gz,BLA203A6_S32_L006_R2_001.fastq.gz,, -WT_INPUT,2,BLA203A30_S21_L001_R1_001.fastq.gz,BLA203A30_S21_L001_R2_001.fastq.gz,, -WT_INPUT,3,BLA203A31_S21_L003_R1_001.fastq.gz,BLA203A31_S21_L003_R2_001.fastq.gz,, -NAIVE_INPUT,1,BLA203A12_S3_L001_R1_001.fastq.gz,BLA203A12_S3_L001_R2_001.fastq.gz,, -NAIVE_INPUT,2,BLA203A48_S39_L001_R1_001.fastq.gz,BLA203A48_S39_L001_R2_001.fastq.gz,, -NAIVE_INPUT,3,BLA203A49_S1_L006_R1_001.fastq.gz,BLA203A49_S1_L006_R2_001.fastq.gz,, diff --git a/assets/design_se.csv b/assets/design_se.csv deleted file mode 100644 index 069a5c943..000000000 --- a/assets/design_se.csv +++ /dev/null @@ -1,21 +0,0 @@ -group,replicate,fastq_1,fastq_2,antibody,control -WT_BCATENIN_IP,1,BLA203A1_S27_L006_R1_001.fastq.gz,,BCATENIN,WT_INPUT -WT_BCATENIN_IP,2,BLA203A25_S16_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT -WT_BCATENIN_IP,2,BLA203A25_S16_L002_R1_001.fastq.gz,,BCATENIN,WT_INPUT -WT_BCATENIN_IP,3,BLA203A49_S40_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT -NAIVE_BCATENIN_IP,1,BLA203A7_S60_L001_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT -NAIVE_BCATENIN_IP,2,BLA203A43_S34_L001_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT -NAIVE_BCATENIN_IP,2,BLA203A43_S34_L002_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT -NAIVE_BCATENIN_IP,3,BLA203A64_S55_L001_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT -WT_TCF4_IP,1,BLA203A3_S29_L006_R1_001.fastq.gz,,TCF4,WT_INPUT -WT_TCF4_IP,2,BLA203A27_S18_L001_R1_001.fastq.gz,,TCF4,WT_INPUT -WT_TCF4_IP,3,BLA203A51_S42_L001_R1_001.fastq.gz,,TCF4,WT_INPUT -NAIVE_TCF4_IP,1,BLA203A9_S62_L001_R1_001.fastq.gz,,TCF4,NAIVE_INPUT -NAIVE_TCF4_IP,2,BLA203A45_S36_L001_R1_001.fastq.gz,,TCF4,NAIVE_INPUT -NAIVE_TCF4_IP,3,BLA203A66_S57_L001_R1_001.fastq.gz,,TCF4,NAIVE_INPUT -WT_INPUT,1,BLA203A6_S32_L006_R1_001.fastq.gz,,, -WT_INPUT,2,BLA203A30_S21_L001_R1_001.fastq.gz,,, -WT_INPUT,3,BLA203A31_S21_L003_R1_001.fastq.gz,,, -NAIVE_INPUT,1,BLA203A12_S3_L001_R1_001.fastq.gz,,, -NAIVE_INPUT,2,BLA203A48_S39_L001_R1_001.fastq.gz,,, -NAIVE_INPUT,3,BLA203A49_S1_L006_R1_001.fastq.gz,,, diff --git a/assets/multiqc/deseq2_clustering_header.txt b/assets/multiqc/deseq2_clustering_header.txt index a5edcb79d..a8e8adb96 100644 --- a/assets/multiqc/deseq2_clustering_header.txt +++ b/assets/multiqc/deseq2_clustering_header.txt @@ -1,9 +1,9 @@ #id: 'deseq2_clustering' #section_name: 'MERGED LIB: DESeq2 sample similarity' -#description: " matrix is generated from clustering by Euclidean distances between -# DESeq2 +#description: "is generated from clustering the Euclidean distances between +# DESeq2 # rlog values for each sample -# (see featurecounts_deseq2.r script)." +# in the deseq2_qc.r script." #plot_type: 'heatmap' #anchor: 'deseq2_clustering' #pconfig: diff --git a/assets/multiqc/deseq2_pca_header.txt b/assets/multiqc/deseq2_pca_header.txt index a086d306c..da7660b02 100644 --- a/assets/multiqc/deseq2_pca_header.txt +++ b/assets/multiqc/deseq2_pca_header.txt @@ -1,8 +1,8 @@ #id: 'deseq2_pca' #section_name: 'MERGED LIB: DESeq2 PCA plot' -#description: "between samples in the experiment. +#description: "PCA plot between samples in the experiment. # These values are calculated using DESeq2 -# in the featurecounts_deseq2.r script." +# in the deseq2_qc.r script." #plot_type: 'scatter' #anchor: 'deseq2_pca' #pconfig: diff --git a/assets/samplesheet.csv b/assets/samplesheet.csv deleted file mode 100644 index 5f653ab7b..000000000 --- a/assets/samplesheet.csv +++ /dev/null @@ -1,3 +0,0 @@ -sample,fastq_1,fastq_2 -SAMPLE_PAIRED_END,/path/to/fastq/files/AEG588A1_S1_L002_R1_001.fastq.gz,/path/to/fastq/files/AEG588A1_S1_L002_R2_001.fastq.gz -SAMPLE_SINGLE_END,/path/to/fastq/files/AEG588A4_S4_L003_R1_001.fastq.gz, diff --git a/assets/samplesheet_pe.csv b/assets/samplesheet_pe.csv new file mode 100644 index 000000000..3a304f121 --- /dev/null +++ b/assets/samplesheet_pe.csv @@ -0,0 +1,21 @@ +sample,fastq_1,fastq_2,antibody,control +WT_BCATENIN_IP_REP1,BLA203A1_S27_L006_R1_001.fastq.gz,BLA203A1_S27_L006_R2_001.fastq.gz,BCATENIN,WT_INPUT +WT_BCATENIN_IP_REP2,BLA203A25_S16_L001_R1_001.fastq.gz,BLA203A25_S16_L001_R2_001.fastq.gz,BCATENIN,WT_INPUT +WT_BCATENIN_IP_REP2,BLA203A25_S16_L002_R1_001.fastq.gz,BLA203A25_S16_L002_R2_001.fastq.gz,BCATENIN,WT_INPUT +WT_BCATENIN_IP_REP3,BLA203A49_S40_L001_R1_001.fastq.gz,BLA203A49_S40_L001_R2_001.fastq.gz,BCATENIN,WT_INPUT +NAIVE_BCATENIN_IP_REP1,BLA203A7_S60_L001_R1_001.fastq.gz,BLA203A7_S60_L001_R2_001.fastq.gz,BCATENIN,NAIVE_INPUT +NAIVE_BCATENIN_IP_REP2,BLA203A43_S34_L001_R1_001.fastq.gz,BLA203A43_S34_L001_R2_001.fastq.gz,BCATENIN,NAIVE_INPUT +NAIVE_BCATENIN_IP_REP2,BLA203A43_S34_L002_R1_001.fastq.gz,BLA203A43_S34_L002_R2_001.fastq.gz,BCATENIN,NAIVE_INPUT +NAIVE_BCATENIN_IP_REP3,BLA203A64_S55_L001_R1_001.fastq.gz,BLA203A64_S55_L001_R2_001.fastq.gz,BCATENIN,NAIVE_INPUT +WT_TCF4_IP_REP1,BLA203A3_S29_L006_R1_001.fastq.gz,BLA203A3_S29_L006_R2_001.fastq.gz,TCF4,WT_INPUT +WT_TCF4_IP_REP2,BLA203A27_S18_L001_R1_001.fastq.gz,BLA203A27_S18_L001_R2_001.fastq.gz,TCF4,WT_INPUT +WT_TCF4_IP_REP2,BLA203A51_S42_L001_R1_001.fastq.gz,BLA203A51_S42_L001_R2_001.fastq.gz,TCF4,WT_INPUT +NAIVE_TCF4_IP_REP1,BLA203A9_S62_L001_R1_001.fastq.gz,BLA203A9_S62_L001_R2_001.fastq.gz,TCF4,NAIVE_INPUT +NAIVE_TCF4_IP_REP2,BLA203A45_S36_L001_R1_001.fastq.gz,BLA203A45_S36_L001_R2_001.fastq.gz,TCF4,NAIVE_INPUT +NAIVE_TCF4_IP_REP3,BLA203A66_S57_L001_R1_001.fastq.gz,BLA203A66_S57_L001_R2_001.fastq.gz,TCF4,NAIVE_INPUT +WT_INPUT_REP1,BLA203A6_S32_L006_R1_001.fastq.gz,BLA203A6_S32_L006_R2_001.fastq.gz,, +WT_INPUT_REP2,BLA203A30_S21_L001_R1_001.fastq.gz,BLA203A30_S21_L001_R2_001.fastq.gz,, +WT_INPUT_REP3,BLA203A31_S21_L003_R1_001.fastq.gz,BLA203A31_S21_L003_R2_001.fastq.gz,, +NAIVE_INPUT_REP1,BLA203A12_S3_L001_R1_001.fastq.gz,BLA203A12_S3_L001_R2_001.fastq.gz,, +NAIVE_INPUT_REP2,BLA203A48_S39_L001_R1_001.fastq.gz,BLA203A48_S39_L001_R2_001.fastq.gz,, +NAIVE_INPUT_REP3,BLA203A49_S1_L006_R1_001.fastq.gz,BLA203A49_S1_L006_R2_001.fastq.gz,, diff --git a/assets/samplesheet_se.csv b/assets/samplesheet_se.csv new file mode 100644 index 000000000..a9581d6e0 --- /dev/null +++ b/assets/samplesheet_se.csv @@ -0,0 +1,21 @@ +sample,fastq_1,fastq_2,antibody,control +WT_BCATENIN_IP_REP1,BLA203A1_S27_L006_R1_001.fastq.gz,,BCATENIN,WT_INPUT +WT_BCATENIN_IP_REP2,BLA203A25_S16_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT +WT_BCATENIN_IP_REP2,BLA203A25_S16_L002_R1_001.fastq.gz,,BCATENIN,WT_INPUT +WT_BCATENIN_IP_REP3,BLA203A49_S40_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT +NAIVE_BCATENIN_IP_REP1,BLA203A7_S60_L001_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT +NAIVE_BCATENIN_IP_REP2,BLA203A43_S34_L001_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT +NAIVE_BCATENIN_IP_REP2,BLA203A43_S34_L002_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT +NAIVE_BCATENIN_IP_REP3,BLA203A64_S55_L001_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT +WT_TCF4_IP_REP1,BLA203A3_S29_L006_R1_001.fastq.gz,,TCF4,WT_INPUT +WT_TCF4_IP_REP2,BLA203A27_S18_L001_R1_001.fastq.gz,,TCF4,WT_INPUT +WT_TCF4_IP_REP3,BLA203A51_S42_L001_R1_001.fastq.gz,,TCF4,WT_INPUT +NAIVE_TCF4_IP_REP1,BLA203A9_S62_L001_R1_001.fastq.gz,,TCF4,NAIVE_INPUT +NAIVE_TCF4_IP_REP2,BLA203A45_S36_L001_R1_001.fastq.gz,,TCF4,NAIVE_INPUT +NAIVE_TCF4_IP_REP3,BLA203A66_S57_L001_R1_001.fastq.gz,,TCF4,NAIVE_INPUT +WT_INPUT_REP1,BLA203A6_S32_L006_R1_001.fastq.gz,,, +WT_INPUT_REP2,BLA203A30_S21_L001_R1_001.fastq.gz,,, +WT_INPUT_REP3,BLA203A31_S21_L003_R1_001.fastq.gz,,, +NAIVE_INPUT_REP1,BLA203A12_S3_L001_R1_001.fastq.gz,,, +NAIVE_INPUT_REP2,BLA203A48_S39_L001_R1_001.fastq.gz,,, +NAIVE_INPUT_REP3,BLA203A49_S1_L006_R1_001.fastq.gz,,, diff --git a/assets/schema_input.json b/assets/schema_input.json index a024fd708..00d941b41 100644 --- a/assets/schema_input.json +++ b/assets/schema_input.json @@ -29,6 +29,16 @@ "maxLength": 0 } ] + }, + "antibody": { + "type": "string", + "pattern": "^\\S+$", + "errorMessage": "Antibody entry cannot contain spaces" + }, + "control": { + "type": "string", + "pattern": "^\\S+$", + "errorMessage": "Control entry cannot contain spaces" } }, "required": [ diff --git a/bin/check_samplesheet.py b/bin/check_samplesheet.py index fdbee3889..91327e5c6 100755 --- a/bin/check_samplesheet.py +++ b/bin/check_samplesheet.py @@ -7,7 +7,7 @@ def parse_args(args=None): - Description = "Reformat nf-core/chipseq samplesheet file and check its contents." + Description = "Reformat nf-core/rnaseq samplesheet file and check its contents." Epilog = "Example usage: python check_samplesheet.py " parser = argparse.ArgumentParser(description=Description, epilog=Epilog) @@ -25,10 +25,10 @@ def make_dir(path): raise exception -def print_error(error, context='Line', context_str=''): - error_str = "ERROR: Please check samplesheet -> {}".format(error) - if context != '' and context_str != '': - error_str = "ERROR: Please check samplesheet -> {}\n{}: '{}'".format(error, context.strip(), context_str.strip()) +def print_error(error, context="Line", context_str=""): + error_str = f"ERROR: Please check samplesheet -> {error}" + if context != "" and context_str != "": + error_str = f"ERROR: Please check samplesheet -> {error}\n{context.strip()}: '{context_str.strip()}'" print(error_str) sys.exit(1) @@ -37,131 +37,141 @@ def check_samplesheet(file_in, file_out): """ This function checks that the samplesheet follows the following structure: - group,replicate,fastq_1,fastq_2,antibody,control - CTCF_IP,1,CTCF_IP_1.fastq.gz,CTCF_IP_2.fastq.gz,CTCF,INPUT - INPUT,1,INPUT_1.fastq.gz,INPUT_IP_2.fastq.gz,, + sample,fastq_1,fastq_2,strandedness + SAMPLE_PE,SAMPLE_PE_RUN1_1.fastq.gz,SAMPLE_PE_RUN1_2.fastq.gz,forward + SAMPLE_PE,SAMPLE_PE_RUN2_1.fastq.gz,SAMPLE_PE_RUN2_2.fastq.gz,forward + SAMPLE_SE,SAMPLE_SE_RUN1_1.fastq.gz,,forward + + For an example see: + https://github.com/nf-core/test-datasets/blob/rnaseq/samplesheet/v3.1/samplesheet_test.csv """ - sample_run_dict = {} - antibody_dict = {} - with open(file_in, "r") as fin: + sample_mapping_dict = {} + with open(file_in, "r", encoding='utf-8-sig') as fin: ## Check header - HEADER = ['group', 'replicate', 'fastq_1', 'fastq_2', 'antibody', 'control'] - header = fin.readline().strip().split(",") - if header != HEADER: - print("ERROR: Please check samplesheet header -> {} != {}".format(",".join(header), ",".join(HEADER))) + MIN_COLS = 3 + HEADER = ["sample", "fastq_1", "fastq_2", "strandedness"] + header = [x.strip('"') for x in fin.readline().strip().split(",")] + if header[: len(HEADER)] != HEADER: + print( + f"ERROR: Please check samplesheet header -> {','.join(header)} != {','.join(HEADER)}" + ) sys.exit(1) ## Check sample entries for line in fin: - lspl = [x.strip() for x in line.strip().split(",")] - sample, replicate, fastq_1, fastq_2, antibody, control = lspl + lspl = [x.strip().strip('"') for x in line.strip().split(",")] ## Check valid number of columns per row - if len(lspl) != len(header): - print_error("Invalid number of columns (minimum = {})!".format(len(header)), 'Line', line) + if len(lspl) < len(HEADER): + print_error( + f"Invalid number of columns (minimum = {len(HEADER)})!", + "Line", + line, + ) num_cols = len([x for x in lspl if x]) - if num_cols < 3: - print_error("Invalid number of populated columns (minimum = 3)!", 'Line', line) + if num_cols < MIN_COLS: + print_error( + f"Invalid number of populated columns (minimum = {MIN_COLS})!", + "Line", + line, + ) ## Check sample name entries - if sample: - if sample.find(" ") != -1: - print_error("Group entry contains spaces!", 'Line', line) - else: - print_error("Group entry has not been specified!", 'Line', line) - - ## Check replicate entry is integer - if not replicate.isdigit(): - print_error("Replicate id not an integer!", 'Line', line) - replicate = int(replicate) + sample, fastq_1, fastq_2, strandedness = lspl[: len(HEADER)] + if sample.find(" ") != -1: + print( + f"WARNING: Spaces have been replaced by underscores for sample: {sample}" + ) + sample = sample.replace(" ", "_") + if not sample: + print_error("Sample entry has not been specified!", "Line", line) ## Check FastQ file extension for fastq in [fastq_1, fastq_2]: if fastq: if fastq.find(" ") != -1: - print_error("FastQ file contains spaces!", 'Line', line) + print_error("FastQ file contains spaces!", "Line", line) if not fastq.endswith(".fastq.gz") and not fastq.endswith(".fq.gz"): - print_error("FastQ file does not have extension '.fastq.gz' or '.fq.gz'!", 'Line', line) - - ## Check antibody and control columns have valid values - if antibody: - if antibody.find(' ') != -1: - print_error("Antibody id contains spaces!", line) - if not control: - print_error("Both antibody and control columns must be specified!", 'Line', line) - if control: - if control.find(' ') != -1: - print_error("Control id contains spaces!", line) - if not antibody: - print_error("Both antibody and control columns must be specified!", 'Line', line) - if antibody and control: - antibody_dict[sample] = (antibody,control) + print_error( + "FastQ file does not have extension '.fastq.gz' or '.fq.gz'!", + "Line", + line, + ) + + ## Check strandedness + strandednesses = ["unstranded", "forward", "reverse"] + if strandedness: + if strandedness not in strandednesses: + print_error( + f"Strandedness must be one of '{', '.join(strandednesses)}'!", + "Line", + line, + ) + else: + print_error( + f"Strandedness has not been specified! Must be one of {', '.join(strandednesses)}.", + "Line", + line, + ) ## Auto-detect paired-end/single-end - sample_info = [] ## [single_end, fastq_1, fastq_2] + sample_info = [] ## [single_end, fastq_1, fastq_2, strandedness] if sample and fastq_1 and fastq_2: ## Paired-end short reads - sample_info = ["0", fastq_1, fastq_2] + sample_info = ["0", fastq_1, fastq_2, strandedness] elif sample and fastq_1 and not fastq_2: ## Single-end short reads - sample_info = ["1", fastq_1, fastq_2] + sample_info = ["1", fastq_1, fastq_2, strandedness] else: - print_error("Invalid combination of columns provided!", 'Line', line) + print_error("Invalid combination of columns provided!", "Line", line) - ## Create sample mapping dictionary = {sample: {replicate : [ single_end, fastq_1, fastq_2 ]}} - if sample not in sample_run_dict: - sample_run_dict[sample] = {} - if replicate not in sample_run_dict[sample]: - sample_run_dict[sample][replicate] = [sample_info] + ## Create sample mapping dictionary = {sample: [[ single_end, fastq_1, fastq_2, strandedness ]]} + if sample not in sample_mapping_dict: + sample_mapping_dict[sample] = [sample_info] else: - if sample_info in sample_run_dict[sample][replicate]: - print_error("Samplesheet contains duplicate rows!", 'Line', line) + if sample_info in sample_mapping_dict[sample]: + print_error("Samplesheet contains duplicate rows!", "Line", line) else: - sample_run_dict[sample][replicate].append(sample_info) - - ## Check if antibody and control columns have been specified at least once - if len(antibody_dict) == 0: - print_error("Antibody and control must be specified at least once!", '', '') + sample_mapping_dict[sample].append(sample_info) ## Write validated samplesheet with appropriate columns - antibody_group_dict = {} - if len(sample_run_dict) > 0: + if len(sample_mapping_dict) > 0: out_dir = os.path.dirname(file_out) make_dir(out_dir) with open(file_out, "w") as fout: - - fout.write(",".join(["sample", "single_end", "fastq_1", "fastq_2", "antibody", "control"]) + "\n") - for sample in sorted(sample_run_dict.keys()): - - ## Check that replicate ids are in format 1.. - uniq_rep_ids = set(sample_run_dict[sample].keys()) - if len(uniq_rep_ids) != max(uniq_rep_ids): - print_error("Replicate IDs must start with 1..!", 'Group', sample) - - for replicate in sorted(sample_run_dict[sample].keys()): - - ## Check that multiple runs of the same sample are of the same datatype - if not all(x[0] == sample_run_dict[sample][replicate][0][0] for x in sample_run_dict[sample][replicate]): - print_error("Multiple runs of a sample must be of the same datatype!", 'Group', sample) - - for idx, sample_info in enumerate(sample_run_dict[sample][replicate]): - sample_id = "{}_R{}_T{}".format(sample,replicate,idx+1) - oList = [sample_id] + sample_info - - ## Extrapolate group column - if sample in antibody_dict: - antibody,control = antibody_dict[sample] - if control in sample_run_dict.keys(): - control_id = "{}_R1".format(control) - if replicate in sample_run_dict[control]: - control_id = "{}_R{}".format(control,replicate) - oList += [antibody, control_id] - else: - print_error("Control id not a valid group: {}!".format(control), 'Valid Groups', sorted(sample_run_dict.keys())) - else: - oList += 2 * [''] - fout.write(','.join(oList) + '\n') + fout.write( + ",".join(["sample", "single_end", "fastq_1", "fastq_2", "strandedness"]) + + "\n" + ) + for sample in sorted(sample_mapping_dict.keys()): + + ## Check that multiple runs of the same sample are of the same datatype i.e. single-end / paired-end + if not all( + x[0] == sample_mapping_dict[sample][0][0] + for x in sample_mapping_dict[sample] + ): + print_error( + f"Multiple runs of a sample must be of the same datatype i.e. single-end or paired-end!", + "Sample", + sample, + ) + + ## Check that multiple runs of the same sample are of the same strandedness + if not all( + x[-1] == sample_mapping_dict[sample][0][-1] + for x in sample_mapping_dict[sample] + ): + print_error( + f"Multiple runs of a sample must have the same strandedness!", + "Sample", + sample, + ) + + for idx, val in enumerate(sample_mapping_dict[sample]): + fout.write(",".join([f"{sample}_T{idx+1}"] + val) + "\n") + else: + print_error(f"No entries to process!", "Samplesheet: {file_in}") def main(args=None): diff --git a/bin/check_samplesheet_old.py b/bin/check_samplesheet_old.py new file mode 100755 index 000000000..fdbee3889 --- /dev/null +++ b/bin/check_samplesheet_old.py @@ -0,0 +1,173 @@ +#!/usr/bin/env python3 + +import os +import sys +import errno +import argparse + + +def parse_args(args=None): + Description = "Reformat nf-core/chipseq samplesheet file and check its contents." + Epilog = "Example usage: python check_samplesheet.py " + + parser = argparse.ArgumentParser(description=Description, epilog=Epilog) + parser.add_argument("FILE_IN", help="Input samplesheet file.") + parser.add_argument("FILE_OUT", help="Output file.") + return parser.parse_args(args) + + +def make_dir(path): + if len(path) > 0: + try: + os.makedirs(path) + except OSError as exception: + if exception.errno != errno.EEXIST: + raise exception + + +def print_error(error, context='Line', context_str=''): + error_str = "ERROR: Please check samplesheet -> {}".format(error) + if context != '' and context_str != '': + error_str = "ERROR: Please check samplesheet -> {}\n{}: '{}'".format(error, context.strip(), context_str.strip()) + print(error_str) + sys.exit(1) + + +def check_samplesheet(file_in, file_out): + """ + This function checks that the samplesheet follows the following structure: + + group,replicate,fastq_1,fastq_2,antibody,control + CTCF_IP,1,CTCF_IP_1.fastq.gz,CTCF_IP_2.fastq.gz,CTCF,INPUT + INPUT,1,INPUT_1.fastq.gz,INPUT_IP_2.fastq.gz,, + """ + + sample_run_dict = {} + antibody_dict = {} + with open(file_in, "r") as fin: + + ## Check header + HEADER = ['group', 'replicate', 'fastq_1', 'fastq_2', 'antibody', 'control'] + header = fin.readline().strip().split(",") + if header != HEADER: + print("ERROR: Please check samplesheet header -> {} != {}".format(",".join(header), ",".join(HEADER))) + sys.exit(1) + + ## Check sample entries + for line in fin: + lspl = [x.strip() for x in line.strip().split(",")] + sample, replicate, fastq_1, fastq_2, antibody, control = lspl + + ## Check valid number of columns per row + if len(lspl) != len(header): + print_error("Invalid number of columns (minimum = {})!".format(len(header)), 'Line', line) + + num_cols = len([x for x in lspl if x]) + if num_cols < 3: + print_error("Invalid number of populated columns (minimum = 3)!", 'Line', line) + + ## Check sample name entries + if sample: + if sample.find(" ") != -1: + print_error("Group entry contains spaces!", 'Line', line) + else: + print_error("Group entry has not been specified!", 'Line', line) + + ## Check replicate entry is integer + if not replicate.isdigit(): + print_error("Replicate id not an integer!", 'Line', line) + replicate = int(replicate) + + ## Check FastQ file extension + for fastq in [fastq_1, fastq_2]: + if fastq: + if fastq.find(" ") != -1: + print_error("FastQ file contains spaces!", 'Line', line) + if not fastq.endswith(".fastq.gz") and not fastq.endswith(".fq.gz"): + print_error("FastQ file does not have extension '.fastq.gz' or '.fq.gz'!", 'Line', line) + + ## Check antibody and control columns have valid values + if antibody: + if antibody.find(' ') != -1: + print_error("Antibody id contains spaces!", line) + if not control: + print_error("Both antibody and control columns must be specified!", 'Line', line) + if control: + if control.find(' ') != -1: + print_error("Control id contains spaces!", line) + if not antibody: + print_error("Both antibody and control columns must be specified!", 'Line', line) + if antibody and control: + antibody_dict[sample] = (antibody,control) + + ## Auto-detect paired-end/single-end + sample_info = [] ## [single_end, fastq_1, fastq_2] + if sample and fastq_1 and fastq_2: ## Paired-end short reads + sample_info = ["0", fastq_1, fastq_2] + elif sample and fastq_1 and not fastq_2: ## Single-end short reads + sample_info = ["1", fastq_1, fastq_2] + else: + print_error("Invalid combination of columns provided!", 'Line', line) + + ## Create sample mapping dictionary = {sample: {replicate : [ single_end, fastq_1, fastq_2 ]}} + if sample not in sample_run_dict: + sample_run_dict[sample] = {} + if replicate not in sample_run_dict[sample]: + sample_run_dict[sample][replicate] = [sample_info] + else: + if sample_info in sample_run_dict[sample][replicate]: + print_error("Samplesheet contains duplicate rows!", 'Line', line) + else: + sample_run_dict[sample][replicate].append(sample_info) + + ## Check if antibody and control columns have been specified at least once + if len(antibody_dict) == 0: + print_error("Antibody and control must be specified at least once!", '', '') + + ## Write validated samplesheet with appropriate columns + antibody_group_dict = {} + if len(sample_run_dict) > 0: + out_dir = os.path.dirname(file_out) + make_dir(out_dir) + with open(file_out, "w") as fout: + + fout.write(",".join(["sample", "single_end", "fastq_1", "fastq_2", "antibody", "control"]) + "\n") + for sample in sorted(sample_run_dict.keys()): + + ## Check that replicate ids are in format 1.. + uniq_rep_ids = set(sample_run_dict[sample].keys()) + if len(uniq_rep_ids) != max(uniq_rep_ids): + print_error("Replicate IDs must start with 1..!", 'Group', sample) + + for replicate in sorted(sample_run_dict[sample].keys()): + + ## Check that multiple runs of the same sample are of the same datatype + if not all(x[0] == sample_run_dict[sample][replicate][0][0] for x in sample_run_dict[sample][replicate]): + print_error("Multiple runs of a sample must be of the same datatype!", 'Group', sample) + + for idx, sample_info in enumerate(sample_run_dict[sample][replicate]): + sample_id = "{}_R{}_T{}".format(sample,replicate,idx+1) + oList = [sample_id] + sample_info + + ## Extrapolate group column + if sample in antibody_dict: + antibody,control = antibody_dict[sample] + if control in sample_run_dict.keys(): + control_id = "{}_R1".format(control) + if replicate in sample_run_dict[control]: + control_id = "{}_R{}".format(control,replicate) + oList += [antibody, control_id] + else: + print_error("Control id not a valid group: {}!".format(control), 'Valid Groups', sorted(sample_run_dict.keys())) + else: + oList += 2 * [''] + fout.write(','.join(oList) + '\n') + + +def main(args=None): + args = parse_args(args) + check_samplesheet(args.FILE_IN, args.FILE_OUT) + + +if __name__ == "__main__": + sys.exit(main()) diff --git a/bin/deseq2_qc.r b/bin/deseq2_qc.r new file mode 100755 index 000000000..edb487143 --- /dev/null +++ b/bin/deseq2_qc.r @@ -0,0 +1,247 @@ +#!/usr/bin/env Rscript + +################################################ +################################################ +## REQUIREMENTS ## +################################################ +################################################ + +## PCA, HEATMAP AND SCATTERPLOTS FOR SAMPLES IN COUNTS FILE +## - SAMPLE NAMES HAVE TO END IN e.g. "_R1" REPRESENTING REPLICATE ID. LAST 3 CHARACTERS OF SAMPLE NAME WILL BE TRIMMED TO OBTAIN GROUP ID FOR DESEQ2 COMPARISONS. +## - PACKAGES BELOW NEED TO BE AVAILABLE TO LOAD WHEN RUNNING R + +################################################ +################################################ +## LOAD LIBRARIES ## +################################################ +################################################ + +library(optparse) +library(DESeq2) +library(ggplot2) +library(RColorBrewer) +library(pheatmap) + +################################################ +################################################ +## PARSE COMMAND-LINE PARAMETERS ## +################################################ +################################################ + +option_list <- list( + make_option(c("-i", "--count_file" ), type="character", default=NULL , metavar="path" , help="Count file matrix where rows are genes and columns are samples." ), + make_option(c("-f", "--count_col" ), type="integer" , default=2 , metavar="integer", help="First column containing sample count data." ), + make_option(c("-d", "--id_col" ), type="integer" , default=1 , metavar="integer", help="Column containing identifiers to be used." ), + make_option(c("-r", "--sample_suffix" ), type="character", default='' , metavar="string" , help="Suffix to remove after sample name in columns e.g. '.rmDup.bam' if 'DRUG_R1.rmDup.bam'."), + make_option(c("-o", "--outdir" ), type="character", default='./' , metavar="path" , help="Output directory." ), + make_option(c("-p", "--outprefix" ), type="character", default='deseq2', metavar="string" , help="Output prefix." ), + make_option(c("-v", "--vst" ), type="logical" , default=FALSE , metavar="boolean", help="Run vst transform instead of rlog." ), + make_option(c("-c", "--cores" ), type="integer" , default=1 , metavar="integer", help="Number of cores." ) +) + +opt_parser <- OptionParser(option_list=option_list) +opt <- parse_args(opt_parser) + +if (is.null(opt$count_file)){ + print_help(opt_parser) + stop("Please provide a counts file.", call.=FALSE) +} + +################################################ +################################################ +## READ IN COUNTS FILE ## +################################################ +################################################ + +count.table <- read.delim(file=opt$count_file,header=TRUE, row.names=NULL) +rownames(count.table) <- count.table[,opt$id_col] +count.table <- count.table[,opt$count_col:ncol(count.table),drop=FALSE] +colnames(count.table) <- gsub(opt$sample_suffix,"",colnames(count.table)) +colnames(count.table) <- gsub(pattern='\\.$', replacement='', colnames(count.table)) + +################################################ +################################################ +## RUN DESEQ2 ## +################################################ +################################################ + +if (file.exists(opt$outdir) == FALSE) { + dir.create(opt$outdir, recursive=TRUE) +} +setwd(opt$outdir) + +samples.vec <- colnames(count.table) +name_components <- strsplit(samples.vec, "_") +n_components <- length(name_components[[1]]) +decompose <- n_components!=1 && all(sapply(name_components, length)==n_components) +coldata <- data.frame(samples.vec, sample=samples.vec, row.names=1) +if (decompose) { + groupings <- as.data.frame(lapply(1:n_components, function(i) sapply(name_components, "[[", i))) + names(groupings) <- paste0("Group", 1:n_components) + n_distinct <- sapply(groupings, function(grp) length(unique(grp))) + groupings <- groupings[n_distinct!=1 & n_distinct!=length(samples.vec)] + if (ncol(groupings)!=0) { + coldata <- cbind(coldata, groupings) + } else { + decompose <- FALSE + } +} + +DDSFile <- paste(opt$outprefix,".dds.RData",sep="") + +counts <- count.table[,samples.vec,drop=FALSE] +dds <- DESeqDataSetFromMatrix(countData=round(counts), colData=coldata, design=~ 1) +dds <- estimateSizeFactors(dds) +if (min(dim(count.table))<=1) { # No point if only one sample, or one gene + save(dds,file=DDSFile) + saveRDS(dds, file=sub("\\.dds\\.RData$", ".rds", DDSFile)) + warning("Not enough samples or genes in counts file for PCA.", call.=FALSE) + quit(save = "no", status = 0, runLast = FALSE) +} +if (!opt$vst) { + vst_name <- "rlog" + rld <- rlog(dds) +} else { + vst_name <- "vst" + rld <- varianceStabilizingTransformation(dds) +} + +assay(dds, vst_name) <- assay(rld) +save(dds,file=DDSFile) +saveRDS(dds, file=sub("\\.dds\\.RData$", ".rds", DDSFile)) + +################################################ +################################################ +## PLOT QC ## +################################################ +################################################ + +##' PCA pre-processeor +##' +##' Generate all the necessary information to plot PCA from a DESeq2 object +##' in which an assay containing a variance-stabilised matrix of counts is +##' stored. Copied from DESeq2::plotPCA, but with additional ability to +##' say which assay to run the PCA on. +##' +##' @param object The DESeq2DataSet object. +##' @param ntop number of top genes to use for principla components, selected by highest row variance. +##' @param assay the name or index of the assay that stores the variance-stabilised data. +##' @return A data.frame containing the projected data alongside the grouping columns. +##' A 'percentVar' attribute is set which includes the percentage of variation each PC explains, +##' and additionally how much the variation within that PC is explained by the grouping variable. +##' @author Gavin Kelly +plotPCA_vst <- function (object, ntop = 500, assay=length(assays(object))) { + rv <- rowVars(assay(object, assay)) + select <- order(rv, decreasing = TRUE)[seq_len(min(ntop, length(rv)))] + pca <- prcomp(t(assay(object, assay)[select, ]), center=TRUE, scale=FALSE) + percentVar <- pca$sdev^2/sum(pca$sdev^2) + df <- cbind( as.data.frame(colData(object)), pca$x) + #Order points so extreme samples are more likely to get label + ord <- order(abs(rank(df$PC1)-median(df$PC1)), abs(rank(df$PC2)-median(df$PC2))) + df <- df[ord,] + attr(df, "percentVar") <- data.frame(PC=seq(along=percentVar), percentVar=100*percentVar) + return(df) +} + +PlotFile <- paste(opt$outprefix,".plots.pdf",sep="") + +pdf(file=PlotFile, onefile=TRUE, width=7, height=7) +## PCA +ntop <- c(500, Inf) +for (n_top_var in ntop) { + pca.data <- plotPCA_vst(dds, assay=vst_name, ntop=n_top_var) + percentVar <- round(attr(pca.data, "percentVar")$percentVar) + plot_subtitle <- ifelse(n_top_var==Inf, "All genes", paste("Top", n_top_var, "genes")) + pl <- ggplot(pca.data, aes(PC1, PC2, label=paste0(" ", sample, " "))) + + geom_point() + + geom_text(check_overlap=TRUE, vjust=0.5, hjust="inward") + + xlab(paste0("PC1: ",percentVar[1],"% variance")) + + ylab(paste0("PC2: ",percentVar[2],"% variance")) + + labs(title = paste0("First PCs on ", vst_name, "-transformed data"), subtitle = plot_subtitle) + + theme(legend.position="top", + panel.grid.major = element_blank(), + panel.grid.minor = element_blank(), + panel.background = element_blank(), + panel.border = element_rect(colour = "black", fill=NA, size=1)) + print(pl) + + if (decompose) { + pc_names <- paste0("PC", attr(pca.data, "percentVar")$PC) + long_pc <- reshape(pca.data, varying=pc_names, direction="long", sep="", timevar="component", idvar="pcrow") + long_pc <- subset(long_pc, component<=5) + long_pc_grp <- reshape(long_pc, varying=names(groupings), direction="long", sep="", timevar="grouper") + long_pc_grp <- subset(long_pc_grp, grouper<=5) + long_pc_grp$component <- paste("PC", long_pc_grp$component) + long_pc_grp$grouper <- paste0(long_pc_grp$grouper, c("st","nd","rd","th","th")[long_pc_grp$grouper], " prefix") + pl <- ggplot(long_pc_grp, aes(x=Group, y=PC)) + + geom_point() + + stat_summary(fun=mean, geom="line", aes(group = 1)) + + labs(x=NULL, y=NULL, subtitle = plot_subtitle, title="PCs split by sample-name prefixes") + + facet_grid(component~grouper, scales="free_x") + + scale_x_discrete(guide = guide_axis(n.dodge = 3)) + print(pl) + } +} # at end of loop, we'll be using the user-defined ntop if any, else all genes + +## WRITE PC1 vs PC2 VALUES TO FILE +pca.vals <- pca.data[,c("PC1","PC2")] +colnames(pca.vals) <- paste0(colnames(pca.vals), ": ", percentVar[1:2], '% variance') +pca.vals <- cbind(sample = rownames(pca.vals), pca.vals) +write.table(pca.vals, file = paste(opt$outprefix, ".pca.vals.txt", sep=""), + row.names = FALSE, col.names = TRUE, sep = "\t", quote = TRUE) + +## SAMPLE CORRELATION HEATMAP +sampleDists <- dist(t(assay(dds, vst_name))) +sampleDistMatrix <- as.matrix(sampleDists) +colors <- colorRampPalette( rev(brewer.pal(9, "Blues")) )(255) +pheatmap( + sampleDistMatrix, + clustering_distance_rows=sampleDists, + clustering_distance_cols=sampleDists, + col=colors, + main=paste("Euclidean distance between", vst_name, "of samples") +) + +## WRITE SAMPLE DISTANCES TO FILE +write.table(cbind(sample = rownames(sampleDistMatrix), sampleDistMatrix),file=paste(opt$outprefix, ".sample.dists.txt", sep=""), + row.names=FALSE, col.names=TRUE, sep="\t", quote=FALSE) +dev.off() + +################################################ +################################################ +## SAVE SIZE FACTORS ## +################################################ +################################################ + +SizeFactorsDir <- "size_factors/" +if (file.exists(SizeFactorsDir) == FALSE) { + dir.create(SizeFactorsDir, recursive=TRUE) +} + +NormFactorsFile <- paste(SizeFactorsDir,opt$outprefix, ".size_factors.RData", sep="") + +normFactors <- sizeFactors(dds) +save(normFactors, file=NormFactorsFile) + +for (name in names(sizeFactors(dds))) { + sizeFactorFile <- paste(SizeFactorsDir,name, ".txt", sep="") + write(as.numeric(sizeFactors(dds)[name]), file=sizeFactorFile) +} + +################################################ +################################################ +## R SESSION INFO ## +################################################ +################################################ + +RLogFile <- "R_sessionInfo.log" + +sink(RLogFile) +a <- sessionInfo() +print(a) +sink() + +################################################ +################################################ +################################################ +################################################ diff --git a/bin/featurecounts_deseq2.r b/bin/featurecounts_deseq2.r deleted file mode 100755 index 32ba77dc7..000000000 --- a/bin/featurecounts_deseq2.r +++ /dev/null @@ -1,301 +0,0 @@ -#!/usr/bin/env Rscript - -################################################ -################################################ -## REQUIREMENTS ## -################################################ -################################################ - -## DIFFERENTIAL ANALYSIS, SCATTERPLOTS AND PCA FOR SAMPLES IN FEATURECOUNTS FILE - ## - FIRST SIX COLUMNS OF FEATURECOUNTS_FILE SHOULD BE INTERVAL INFO. REMAINDER OF COLUMNS SHOULD BE SAMPLES-SPECIFIC COUNTS. - ## - SAMPLE NAMES HAVE TO END IN "_R1" REPRESENTING REPLICATE ID. LAST 3 CHARACTERS OF SAMPLE NAME WILL BE TRIMMED TO OBTAIN GROUP ID FOR DESEQ2 COMPARISONS. - ## - BAM_SUFFIX IS PORTION OF FILENAME AFTER SAMPLE NAME IN FEATURECOUNTS COLUMN SAMPLE NAMES E.G. ".rmDup.bam" if "DRUG_R1.rmDup.bam" - ## - PACKAGES BELOW NEED TO BE AVAILABLE TO LOAD WHEN RUNNING R - -################################################ -################################################ -## LOAD LIBRARIES ## -################################################ -################################################ - -library(optparse) -library(DESeq2) -library(vsn) -library(ggplot2) -library(RColorBrewer) -library(pheatmap) -library(lattice) -library(BiocParallel) - -################################################ -################################################ -## PARSE COMMAND-LINE PARAMETERS ## -################################################ -################################################ - -option_list <- list(make_option(c("-i", "--featurecount_file"), type="character", default=NULL, help="Feature count file generated by the SubRead featureCounts command.", metavar="path"), - make_option(c("-b", "--bam_suffix"), type="character", default=NULL, help="Portion of filename after sample name in featurecount file header e.g. '.rmDup.bam' if 'DRUG_R1.rmDup.bam'", metavar="string"), - make_option(c("-o", "--outdir"), type="character", default='./', help="Output directory", metavar="path"), - make_option(c("-p", "--outprefix"), type="character", default='differential', help="Output prefix", metavar="string"), - make_option(c("-s", "--outsuffix"), type="character", default='', help="Output suffix for comparison-level results", metavar="string"), - make_option(c("-v", "--vst"), type="logical", default=FALSE, help="Run vst transform instead of rlog", metavar="boolean"), - make_option(c("-c", "--cores"), type="integer", default=1, help="Number of cores", metavar="integer")) - -opt_parser <- OptionParser(option_list=option_list) -opt <- parse_args(opt_parser) - -if (is.null(opt$featurecount_file)){ - print_help(opt_parser) - stop("Please provide featurecount file.", call.=FALSE) -} -if (is.null(opt$bam_suffix)){ - print_help(opt_parser) - stop("Please provide bam suffix in header of featurecount file.", call.=FALSE) -} - -################################################ -################################################ -## READ IN COUNTS FILE ## -################################################ -################################################ - -count.table <- read.delim(file=opt$featurecount_file,header=TRUE,skip=1) -colnames(count.table) <- gsub(opt$bam_suffix,"",colnames(count.table)) -colnames(count.table) <- as.character(lapply(colnames(count.table), function (x) tail(strsplit(x,'.',fixed=TRUE)[[1]],1))) -rownames(count.table) <- count.table$Geneid -interval.table <- count.table[,1:6] -count.table <- count.table[,7:ncol(count.table),drop=FALSE] - -################################################ -################################################ -## RUN DESEQ2 ## -################################################ -################################################ - -if (file.exists(opt$outdir) == FALSE) { - dir.create(opt$outdir,recursive=TRUE) -} -setwd(opt$outdir) - -samples.vec <- sort(colnames(count.table)) -groups <- sub("_[^_]+$", "", samples.vec) -print(unique(groups)) -if (length(unique(groups)) == 1) { - quit(save = "no", status = 0, runLast = FALSE) -} - -DDSFile <- paste(opt$outprefix,".dds.rld.RData",sep="") -if (file.exists(DDSFile) == FALSE) { - counts <- count.table[,samples.vec,drop=FALSE] - coldata <- data.frame(row.names=colnames(counts),condition=groups) - dds <- DESeqDataSetFromMatrix(countData = round(counts), colData = coldata, design = ~ condition) - dds <- DESeq(dds, parallel=TRUE, BPPARAM=MulticoreParam(opt$cores)) - if (!opt$vst) { - rld <- rlog(dds) - } else { - rld <- vst(dds) - } - save(dds,rld,file=DDSFile) -} - -################################################ -################################################ -## PLOT QC ## -################################################ -################################################ - -PlotFile <- paste(opt$outprefix,".plots.pdf",sep="") -if (file.exists(PlotFile) == FALSE) { - pdf(file=PlotFile,onefile=TRUE,width=7,height=7) - - ## PCA - pca.data <- DESeq2::plotPCA(rld,intgroup=c("condition"),returnData=TRUE) - percentVar <- round(100 * attr(pca.data, "percentVar")) - plot <- ggplot(pca.data, aes(PC1, PC2, color=condition)) + - geom_point(size=3) + - xlab(paste0("PC1: ",percentVar[1],"% variance")) + - ylab(paste0("PC2: ",percentVar[2],"% variance")) + - theme(panel.grid.major = element_blank(), - panel.grid.minor = element_blank(), - panel.background = element_blank(), - panel.border = element_rect(colour = "black", fill=NA, size=1)) - print(plot) - - ## WRITE PC1 vs PC2 VALUES TO FILE - pca.vals <- pca.data[,1:2] - colnames(pca.vals) <- paste(colnames(pca.vals),paste(percentVar,'% variance',sep=""), sep=": ") - pca.vals <- cbind(sample = rownames(pca.vals), pca.vals) - write.table(pca.vals,file=paste(opt$outprefix,".pca.vals.txt",sep=""),row.names=FALSE,col.names=TRUE,sep="\t",quote=TRUE) - - ## SAMPLE CORRELATION HEATMAP - sampleDists <- dist(t(assay(rld))) - sampleDistMatrix <- as.matrix(sampleDists) - colors <- colorRampPalette( rev(brewer.pal(9, "Blues")) )(255) - pheatmap(sampleDistMatrix,clustering_distance_rows=sampleDists,clustering_distance_cols=sampleDists,col=colors) - - ## WRITE SAMPLE DISTANCES TO FILE - write.table(cbind(sample = rownames(sampleDistMatrix), sampleDistMatrix),file=paste(opt$outprefix,".sample.dists.txt",sep=""),row.names=FALSE,col.names=TRUE,sep="\t",quote=FALSE) - - dev.off() -} - -################################################ -################################################ -## SAVE SIZE FACTORS ## -################################################ -################################################ - -SizeFactorsDir <- "sizeFactors/" -if (file.exists(SizeFactorsDir) == FALSE) { - dir.create(SizeFactorsDir,recursive=TRUE) -} - -NormFactorsFile <- paste(SizeFactorsDir,opt$outprefix,".sizeFactors.RData",sep="") -if (file.exists(NormFactorsFile) == FALSE) { - normFactors <- sizeFactors(dds) - save(normFactors,file=NormFactorsFile) - - for (name in names(sizeFactors(dds))) { - sizeFactorFile <- paste(SizeFactorsDir,name,opt$outsuffix,".sizeFactor.txt",sep="") - if (file.exists(sizeFactorFile) == FALSE) { - write(as.numeric(sizeFactors(dds)[name]),file=sizeFactorFile) - } - } -} - -################################################ -################################################ -## WRITE LOG FILE ## -################################################ -################################################ - -LogFile <- paste(opt$outprefix,".log",sep="") -if (file.exists(LogFile) == FALSE) { - cat("\nSamples =",samples.vec,"\n\n",file=LogFile,append=TRUE,sep=', ') - cat("Groups =",groups,"\n\n",file=LogFile,append=TRUE,sep=', ') - cat("Dimensions of count matrix =",dim(counts),"\n\n",file=LogFile,append=FALSE,sep=' ') - cat("\n",file=LogFile,append=TRUE,sep='') -} - -################################################ -################################################ -## LOOP THROUGH COMPARISONS ## -################################################ -################################################ - -ResultsFile <- paste(opt$outprefix,".results.txt",sep="") -if (file.exists(ResultsFile) == FALSE) { - - raw.counts <- counts(dds,normalized=FALSE) - colnames(raw.counts) <- paste(colnames(raw.counts),'raw',sep='.') - pseudo.counts <- counts(dds,normalized=TRUE) - colnames(pseudo.counts) <- paste(colnames(pseudo.counts),'pseudo',sep='.') - - deseq2_results_list <- list() - comparisons <- combn(unique(groups),2) - for (idx in 1:ncol(comparisons)) { - - control.group <- comparisons[1,idx] - treat.group <- comparisons[2,idx] - CompPrefix <- paste(control.group,treat.group,sep="vs") - cat("Saving results for ",CompPrefix," ...\n",sep="") - - CompOutDir <- paste(CompPrefix,'/',sep="") - if (file.exists(CompOutDir) == FALSE) { - dir.create(CompOutDir,recursive=TRUE) - } - - control.samples <- samples.vec[which(groups == control.group)] - treat.samples <- samples.vec[which(groups == treat.group)] - comp.samples <- c(control.samples,treat.samples) - - comp.results <- results(dds,contrast=c("condition",c(control.group,treat.group))) - comp.df <- as.data.frame(comp.results) - comp.table <- cbind(interval.table, as.data.frame(comp.df), raw.counts[,paste(comp.samples,'raw',sep='.')], pseudo.counts[,paste(comp.samples,'pseudo',sep='.')]) - - ## WRITE RESULTS FILE - CompResultsFile <- paste(CompOutDir,CompPrefix,opt$outsuffix,".deseq2.results.txt",sep="") - write.table(comp.table, file=CompResultsFile, col.names=TRUE, row.names=FALSE, sep='\t', quote=FALSE) - - ## FILTER RESULTS BY FDR & LOGFC AND WRITE RESULTS FILE - pdf(file=paste(CompOutDir,CompPrefix,opt$outsuffix,".deseq2.plots.pdf",sep=""),width=10,height=8) - if (length(comp.samples) > 2) { - for (MIN_FDR in c(0.01,0.05)) { - - ## SUBSET RESULTS BY FDR - pass.fdr.table <- subset(comp.table, padj < MIN_FDR) - pass.fdr.up.table <- subset(comp.table, padj < MIN_FDR & log2FoldChange > 0) - pass.fdr.down.table <- subset(comp.table, padj < MIN_FDR & log2FoldChange < 0) - - ## SUBSET RESULTS BY FDR AND LOGFC - pass.fdr.logFC.table <- subset(comp.table, padj < MIN_FDR & abs(log2FoldChange) >= 1) - pass.fdr.logFC.up.table <- subset(comp.table, padj < MIN_FDR & abs(log2FoldChange) >= 1 & log2FoldChange > 0) - pass.fdr.logFC.down.table <- subset(comp.table, padj < MIN_FDR & abs(log2FoldChange) >= 1 & log2FoldChange < 0) - - ## WRITE RESULTS FILE - CompResultsFile <- paste(CompOutDir,CompPrefix,opt$outsuffix,".deseq2.FDR",MIN_FDR,".results.txt",sep="") - CompBEDFile <- paste(CompOutDir,CompPrefix,opt$outsuffix,".deseq2.FDR",MIN_FDR,".results.bed",sep="") - write.table(pass.fdr.table, file=CompResultsFile, col.names=TRUE, row.names=FALSE, sep='\t', quote=FALSE) - write.table(pass.fdr.table[,c("Chr","Start","End","Geneid","log2FoldChange","Strand")], file=CompBEDFile, col.names=FALSE, row.names=FALSE, sep='\t', quote=FALSE) - - ## MA PLOT & VOLCANO PLOT - DESeq2::plotMA(comp.results, main=paste("MA plot FDR <= ",MIN_FDR,sep=""), ylim=c(-2,2),alpha=MIN_FDR) - plot(comp.table$log2FoldChange, -1*log10(comp.table$padj), col=ifelse(comp.table$padj<=MIN_FDR, "red", "black"), xlab="logFC", ylab="-1*log10(FDR)", main=paste("Volcano plot FDR <=",MIN_FDR,sep=" "), pch=20) - - ## ADD COUNTS TO LOGFILE - cat(CompPrefix," genes with FDR <= ",MIN_FDR,": ",nrow(pass.fdr.table)," (up=",nrow(pass.fdr.up.table),", down=",nrow(pass.fdr.down.table),")","\n",file=LogFile,append=TRUE,sep="") - cat(CompPrefix," genes with FDR <= ",MIN_FDR," & FC > 2: ",nrow(pass.fdr.logFC.table)," (up=",nrow(pass.fdr.logFC.up.table),", down=",nrow(pass.fdr.logFC.down.table),")","\n",file=LogFile,append=TRUE,sep="") - - } - cat("\n",file=LogFile,append=TRUE,sep="") - } - - ## SAMPLE CORRELATION HEATMAP - rld.subset <- assay(rld)[,comp.samples] - sampleDists <- dist(t(rld.subset)) - sampleDistMatrix <- as.matrix(sampleDists) - colors <- colorRampPalette( rev(brewer.pal(9, "Blues")) )(255) - pheatmap(sampleDistMatrix,clustering_distance_rows=sampleDists,clustering_distance_cols=sampleDists,col=colors) - - ## SCATTER PLOT FOR RLOG COUNTS - combs <- combn(comp.samples,2,simplify=FALSE) - clabels <- sapply(combs,function(x){paste(x,collapse=' & ')}) - plotdat <- data.frame(x=unlist(lapply(combs, function(x){rld.subset[, x[1] ]})),y=unlist(lapply(combs, function(y){rld.subset[, y[2] ]})),comp=rep(clabels, each=nrow(rld.subset))) - plot <- xyplot(y~x|comp,plotdat, - panel=function(...){ - panel.xyplot(...) - panel.abline(0,1,col="red") - }, - par.strip.text=list(cex=0.5)) - print(plot) - dev.off() - - colnames(comp.df) <- paste(CompPrefix,".",colnames(comp.df),sep="") - deseq2_results_list[[idx]] <- comp.df - - } - - ## WRITE RESULTS FROM ALL COMPARISONS TO FILE - deseq2_results_table <- cbind(interval.table,do.call(cbind, deseq2_results_list),raw.counts,pseudo.counts) - write.table(deseq2_results_table, file=ResultsFile, col.names=TRUE, row.names=FALSE, sep='\t', quote=FALSE) - -} - -################################################ -################################################ -## R SESSION INFO ## -################################################ -################################################ - -RLogFile <- "R_sessionInfo.log" -if (file.exists(RLogFile) == FALSE) { - sink(RLogFile) - a <- sessionInfo() - print(a) - sink() -} - -################################################ -################################################ -################################################ -################################################ diff --git a/bin/markdown_to_html.py b/bin/markdown_to_html.py deleted file mode 100755 index 13350d440..000000000 --- a/bin/markdown_to_html.py +++ /dev/null @@ -1,92 +0,0 @@ -#!/usr/bin/env python3 - -from __future__ import print_function -import argparse -import markdown -import os -import sys -import io - - -def convert_markdown(in_fn): - input_md = io.open(in_fn, mode="r", encoding="utf-8").read() - html = markdown.markdown( - "[TOC]\n" + input_md, - extensions=["pymdownx.extra", "pymdownx.b64", "pymdownx.highlight", "pymdownx.emoji", "pymdownx.tilde", "toc"], - extension_configs={ - "pymdownx.b64": {"base_path": os.path.dirname(in_fn)}, - "pymdownx.highlight": {"noclasses": True}, - "toc": {"title": "Table of Contents"}, - }, - ) - return html - - -def wrap_html(contents): - header = """ - - - - - -
- """ - footer = """ -
- - - """ - return header + contents + footer - - -def parse_args(args=None): - parser = argparse.ArgumentParser() - parser.add_argument("mdfile", type=argparse.FileType("r"), nargs="?", help="File to convert. Defaults to stdin.") - parser.add_argument( - "-o", "--out", type=argparse.FileType("w"), default=sys.stdout, help="Output file name. Defaults to stdout." - ) - return parser.parse_args(args) - - -def main(args=None): - args = parse_args(args) - converted_md = convert_markdown(args.mdfile.name) - html = wrap_html(converted_md) - args.out.write(html) - - -if __name__ == "__main__": - sys.exit(main()) diff --git a/conf/modules.config b/conf/modules.config index b514aeb0d..ae0f6c356 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -153,13 +153,9 @@ params { args = "-F SAF -O --fracOverlap 0.2" publish_dir = "bwa/mergedLibrary/macs2" } - 'deseq2_featurecounts' { - publish_dir = "bwa/mergedLibrary/macs2" - } - 'get_software_versions' { - publish_dir = "pipeline_info" - publish_files = ['csv':''] - } + //'deseq2_featurecounts' { + // publish_dir = "bwa/mergedLibrary/macs2" + //} 'multiqc' { args = '' publish_dir = "multiqc" diff --git a/conf/test_full.config b/conf/test_full.config old mode 100755 new mode 100644 diff --git a/docs/usage.md b/docs/usage.md index 68caa1da7..be0b64545 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -4,124 +4,64 @@ > _Documentation of pipeline parameters is generated automatically from the pipeline schema and can no longer be found in markdown files._ -## Introduction -You will need to create a design file with information about the samples in your experiment before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 6 columns, and a header row as shown in the examples below. - -```bash ---input '[path to design file]' -``` - -### Multiple replicates - -The `group` identifier should be identical when you have multiple replicates from the same experimental group, just increment the `replicate` identifier appropriately. The first replicate value for any given experimental group must be 1. - -The `antibody` column is required to separate the downstream consensus peak merging and differential analysis for different antibodies. Its not advisable to generate a consensus peak set across different antibodies especially if their binding patterns are inherently different e.g. narrow transcription factors and broad histone marks. - -The `control` column should be the `group` identifier for the controls for any given IP. The pipeline will automatically pair the inputs based on replicate identifier (i.e. where you have an equal number of replicates for your IP's and controls), alternatively, the first control sample in that group will be selected. +## Samplesheet input -In the single-end design below there are triplicate samples for the `WT_BCATENIN_IP` group along with triplicate samples for their corresponding `WT_INPUT` samples. +You will need to create a samplesheet with information about the samples you would like to analyse before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 5 columns, and a header row as shown in the examples below. -```bash -group,replicate,fastq_1,fastq_2,antibody,control -WT_BCATENIN_IP,1,BLA203A1_S27_L006_R1_001.fastq.gz,,BCATENIN,WT_INPUT -WT_BCATENIN_IP,2,BLA203A25_S16_L002_R1_001.fastq.gz,,BCATENIN,WT_INPUT -WT_BCATENIN_IP,3,BLA203A49_S40_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT -WT_INPUT,1,BLA203A6_S32_L006_R1_001.fastq.gz,,, -WT_INPUT,2,BLA203A30_S21_L002_R1_001.fastq.gz,,, -WT_INPUT,3,BLA203A31_S21_L003_R1_001.fastq.gz,,, +```console +--input '[path to samplesheet file]' ``` ### Multiple runs of the same library -Both the `group` and `replicate` identifiers should be the same when you have re-sequenced the same sample more than once e.g. to increase sequencing depth. The pipeline will perform the alignments in parallel, and subsequently merge them before further analysis. Below is an example where the second replicate of the `WT_BCATENIN_IP` and `WT_INPUT` groups has been re-sequenced multiple times: +The `sample` identifiers have to be the same when you have re-sequenced the same sample more than once e.g. to increase sequencing depth. The pipeline will perform the alignments in parallel, and subsequently merge them before further analysis. Below is an example where the samples called `WT_BCATENIN_IP_REP2` and `WT_INPUT_REP2` have been re-sequenced multiple times: ```bash -group,replicate,fastq_1,fastq_2,antibody,control -WT_BCATENIN_IP,1,BLA203A1_S27_L006_R1_001.fastq.gz,,BCATENIN,WT_INPUT -WT_BCATENIN_IP,2,BLA203A25_S16_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT -WT_BCATENIN_IP,2,BLA203A25_S16_L002_R1_001.fastq.gz,,BCATENIN,WT_INPUT -WT_BCATENIN_IP,2,BLA203A25_S16_L003_R1_001.fastq.gz,,BCATENIN,WT_INPUT -WT_BCATENIN_IP,3,BLA203A49_S40_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT -WT_INPUT,1,BLA203A6_S32_L006_R1_001.fastq.gz,,, -WT_INPUT,2,BLA203A30_S21_L001_R1_001.fastq.gz,,, -WT_INPUT,2,BLA203A30_S21_L002_R1_001.fastq.gz,,, -WT_INPUT,3,BLA203A31_S21_L003_R1_001.fastq.gz,,, +sample,fastq_1,fastq_2,antibody,control +WT_BCATENIN_IP_REP1,BLA203A1_S27_L006_R1_001.fastq.gz,,BCATENIN,WT_INPUT +WT_BCATENIN_IP_REP2,BLA203A25_S16_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT +WT_BCATENIN_IP_REP2,BLA203A25_S16_L002_R1_001.fastq.gz,,BCATENIN,WT_INPUT +WT_BCATENIN_IP_REP2,BLA203A25_S16_L003_R1_001.fastq.gz,,BCATENIN,WT_INPUT +WT_BCATENIN_IP_REP3,BLA203A49_S40_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT +WT_INPUT_REP1,BLA203A6_S32_L006_R1_001.fastq.gz,,, +WT_INPUT_REP2,BLA203A30_S21_L001_R1_001.fastq.gz,,, +WT_INPUT_REP2,BLA203A30_S21_L002_R1_001.fastq.gz,,, +WT_INPUT_REP3,BLA203A31_S21_L003_R1_001.fastq.gz,,, ``` ### Full design -A final design file may look something like the one below. This is for two antibodies and associated controls in triplicate, where the second replicate of the `WT_BCATENIN_IP` and `NAIVE_BCATENIN_IP` group has been sequenced twice: - -```bash -group,replicate,fastq_1,fastq_2,antibody,control -WT_BCATENIN_IP,1,BLA203A1_S27_L006_R1_001.fastq.gz,,BCATENIN,WT_INPUT -WT_BCATENIN_IP,2,BLA203A25_S16_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT -WT_BCATENIN_IP,2,BLA203A25_S16_L002_R1_001.fastq.gz,,BCATENIN,WT_INPUT -WT_BCATENIN_IP,3,BLA203A49_S40_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT -NAIVE_BCATENIN_IP,1,BLA203A7_S60_L001_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT -NAIVE_BCATENIN_IP,2,BLA203A43_S34_L001_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT -NAIVE_BCATENIN_IP,2,BLA203A43_S34_L002_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT -NAIVE_BCATENIN_IP,3,BLA203A64_S55_L001_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT -WT_TCF4_IP,1,BLA203A3_S29_L006_R1_001.fastq.gz,,TCF4,WT_INPUT -WT_TCF4_IP,2,BLA203A27_S18_L001_R1_001.fastq.gz,,TCF4,WT_INPUT -WT_TCF4_IP,3,BLA203A51_S42_L001_R1_001.fastq.gz,,TCF4,WT_INPUT -NAIVE_TCF4_IP,1,BLA203A9_S62_L001_R1_001.fastq.gz,,TCF4,NAIVE_INPUT -NAIVE_TCF4_IP,2,BLA203A45_S36_L001_R1_001.fastq.gz,,TCF4,NAIVE_INPUT -NAIVE_TCF4_IP,3,BLA203A66_S57_L001_R1_001.fastq.gz,,TCF4,NAIVE_INPUT -WT_INPUT,1,BLA203A6_S32_L006_R1_001.fastq.gz,,, -WT_INPUT,2,BLA203A30_S21_L001_R1_001.fastq.gz,,, -WT_INPUT,3,BLA203A31_S21_L003_R1_001.fastq.gz,,, -NAIVE_INPUT,1,BLA203A12_S3_L001_R1_001.fastq.gz,,, -NAIVE_INPUT,2,BLA203A48_S39_L001_R1_001.fastq.gz,,, -NAIVE_INPUT,3,BLA203A49_S1_L006_R1_001.fastq.gz,,, -``` - -| Column | Description | -|-------------|--------------------------------------------------------------------------------------------------------------------------------------------------| -| `group` | Group/condition identifier for sample. This will be identical for re-sequenced libraries and replicate samples from the same experimental group. | -| `replicate` | Integer representing replicate number. This will be identical for re-sequenced libraries. Must start from `1..`. | -| `fastq_1` | Full path to FastQ file for read 1. File has to be zipped and have the extension ".fastq.gz" or ".fq.gz". | -| `fastq_2` | Full path to FastQ file for read 2. File has to be zipped and have the extension ".fastq.gz" or ".fq.gz". | -| `antibody` | Antibody name. This is required to segregate downstream analysis for different antibodies. Required when `control` is specified. | -| `control` | Group identifier for control sample. The pipeline will automatically select the control sample with the same replicate identifier as the IP. | - -Example design files have been provided with the pipeline for [paired-end](../assets/design_pe.csv) and [single-end](../assets/design_se.csv) data. - -## Samplesheet input +The pipeline will auto-detect whether a sample is single- or paired-end using the information provided in the samplesheet. The samplesheet can have as many columns as you desire, however, there is a strict requirement for the first 5 columns to match those defined in the table below. -You will need to create a samplesheet with information about the samples you would like to analyse before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 3 columns, and a header row as shown in the examples below. - -```console ---input '[path to samplesheet file]' -``` - -### Multiple runs of the same sample - -The `sample` identifiers have to be the same when you have re-sequenced the same sample more than once e.g. to increase sequencing depth. The pipeline will concatenate the raw reads before performing any downstream analysis. Below is an example for the same sample sequenced across 3 lanes: - -```console -sample,fastq_1,fastq_2 -CONTROL_REP1,AEG588A1_S1_L002_R1_001.fastq.gz,AEG588A1_S1_L002_R2_001.fastq.gz -CONTROL_REP1,AEG588A1_S1_L003_R1_001.fastq.gz,AEG588A1_S1_L003_R2_001.fastq.gz -CONTROL_REP1,AEG588A1_S1_L004_R1_001.fastq.gz,AEG588A1_S1_L004_R2_001.fastq.gz -``` - -### Full samplesheet +The `antibody` column is required to separate the downstream consensus peak merging and differential analysis for different antibodies. Its not advisable to generate a consensus peak set across different antibodies especially if their binding patterns are inherently different e.g. narrow transcription factors and broad histone marks. -The pipeline will auto-detect whether a sample is single- or paired-end using the information provided in the samplesheet. The samplesheet can have as many columns as you desire, however, there is a strict requirement for the first 3 columns to match those defined in the table below. +The `control` column should be the `sample` identifier for the controls for any given IP. -A final samplesheet file consisting of both single- and paired-end data may look something like the one below. This is for 6 samples, where `TREATMENT_REP3` has been sequenced twice. +A final design file may look something like the one below. This is for two antibodies and associated controls, where the `WT_BCATENIN_IP_REP2` and `NAIVE_BCATENIN_IP_REP2` samples have been sequenced twice: -```console -sample,fastq_1,fastq_2 -CONTROL_REP1,AEG588A1_S1_L002_R1_001.fastq.gz,AEG588A1_S1_L002_R2_001.fastq.gz -CONTROL_REP2,AEG588A2_S2_L002_R1_001.fastq.gz,AEG588A2_S2_L002_R2_001.fastq.gz -CONTROL_REP3,AEG588A3_S3_L002_R1_001.fastq.gz,AEG588A3_S3_L002_R2_001.fastq.gz -TREATMENT_REP1,AEG588A4_S4_L003_R1_001.fastq.gz, -TREATMENT_REP2,AEG588A5_S5_L003_R1_001.fastq.gz, -TREATMENT_REP3,AEG588A6_S6_L003_R1_001.fastq.gz, -TREATMENT_REP3,AEG588A6_S6_L004_R1_001.fastq.gz, +```bash +sample,fastq_1,fastq_2,antibody,control +WT_BCATENIN_IP_REP1,BLA203A1_S27_L006_R1_001.fastq.gz,,BCATENIN,WT_INPUT +WT_BCATENIN_IP_REP2,BLA203A25_S16_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT +WT_BCATENIN_IP_REP2,BLA203A25_S16_L002_R1_001.fastq.gz,,BCATENIN,WT_INPUT +WT_BCATENIN_IP_REP3,BLA203A49_S40_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT +NAIVE_BCATENIN_IP_REP1,BLA203A7_S60_L001_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT +NAIVE_BCATENIN_IP_REP2,BLA203A43_S34_L001_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT +NAIVE_BCATENIN_IP_REP2,BLA203A43_S34_L002_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT +NAIVE_BCATENIN_IP_REP3,BLA203A64_S55_L001_R1_001.fastq.gz,,BCATENIN,NAIVE_INPUT +WT_TCF4_IP_REP1,BLA203A3_S29_L006_R1_001.fastq.gz,,TCF4,WT_INPUT +WT_TCF4_IP_REP2,BLA203A27_S18_L001_R1_001.fastq.gz,,TCF4,WT_INPUT +WT_TCF4_IP_REP3,BLA203A51_S42_L001_R1_001.fastq.gz,,TCF4,WT_INPUT +NAIVE_TCF4_IP_REP1,BLA203A9_S62_L001_R1_001.fastq.gz,,TCF4,NAIVE_INPUT +NAIVE_TCF4_IP_REP2,BLA203A45_S36_L001_R1_001.fastq.gz,,TCF4,NAIVE_INPUT +NAIVE_TCF4_IP_REP3,BLA203A66_S57_L001_R1_001.fastq.gz,,TCF4,NAIVE_INPUT +WT_INPUT_REP1,BLA203A6_S32_L006_R1_001.fastq.gz,,, +WT_INPUT_REP2,BLA203A30_S21_L001_R1_001.fastq.gz,,, +WT_INPUT_REP3,BLA203A31_S21_L003_R1_001.fastq.gz,,, +NAIVE_INPUT_REP1,BLA203A12_S3_L001_R1_001.fastq.gz,,, +NAIVE_INPUT_REP2,BLA203A48_S39_L001_R1_001.fastq.gz,,, +NAIVE_INPUT_REP3,BLA203A49_S1_L006_R1_001.fastq.gz,,, ``` | Column | Description | @@ -129,15 +69,28 @@ TREATMENT_REP3,AEG588A6_S6_L004_R1_001.fastq.gz, | `sample` | Custom sample name. This entry will be identical for multiple sequencing libraries/runs from the same sample. Spaces in sample names are automatically converted to underscores (`_`). | | `fastq_1` | Full path to FastQ file for Illumina short reads 1. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | | `fastq_2` | Full path to FastQ file for Illumina short reads 2. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | +| `antibody` | Antibody name. This is required to segregate downstream analysis for different antibodies. Required when `control` is specified. | +| `control` | Sample name for control sample. | + +Example design files have been provided with the pipeline for [paired-end](../assets/samplesheet_pe.csv) and [single-end](../assets/samplesheet_se.csv) data. + +> **NB:** The `group` and `replicate` columns were replaced with a single `sample` column as of v2.0 of the pipeline. The `sample` column is essentially a concatenation of the `group` and `replicate` columns. If all values of `sample` have the same number of underscores, fields defined by these underscore-separated names may be used in the PCA plots produced by the pipeline, to regain the ability to represent different groupings. + +## Reference genome files + +The minimum reference genome requirements are a FASTA and GTF file, all other files required to run the pipeline can be generated from these files. However, it is more storage and compute friendly if you are able to re-use reference genome files as efficiently as possible. It is recommended to use the `--save_reference` parameter if you are using the pipeline to build new indices (e.g. those unavailable on [AWS iGenomes](https://nf-co.re/usage/reference_genomes)) so that you can save them somewhere locally. The index building step can be quite a time-consuming process and it permits their reuse for future runs of the pipeline to save disk space. You can then either provide the appropriate reference genome files on the command-line via the appropriate parameters (e.g. `--bwa_index '/path/to/bwa/index/'`) or via a custom config file. + +* If `--genome` is provided then the FASTA and GTF files (and existing indices) will be automatically obtained from AWS-iGenomes unless these have already been downloaded locally in the path specified by `--igenomes_base`. +* If `--gene_bed` is not provided then it will be generated from the GTF file. -An [example samplesheet](../assets/samplesheet.csv) has been provided with the pipeline. +> **NB:** Compressed reference files are also supported by the pipeline i.e. standard files with the `.gz` extension and indices folders with the `tar.gz` extension. ## Running the pipeline The typical command for running the pipeline is as follows: ```bash -nextflow run nf-core/chipseq --input design.csv --genome GRCh37 -profile docker +nextflow run nf-core/chipseq --input samplesheet.csv --genome GRCh37 -profile docker ``` This will launch the pipeline with the `docker` configuration profile. See below for more information about profiles. diff --git a/lib/Completion.groovy b/lib/Completion.groovy deleted file mode 100755 index 67e8322c1..000000000 --- a/lib/Completion.groovy +++ /dev/null @@ -1,117 +0,0 @@ -/* - * Functions to be run on completion of pipeline - */ - -class Completion { - static void email(workflow, params, summary, run_name, projectDir, multiqc_report, log) { - - // Set up the e-mail variables - def subject = "[$workflow.manifest.name] Successful: $workflow.runName" - if (!workflow.success) { - subject = "[$workflow.manifest.name] FAILED: $workflow.runName" - } - - def email_fields = [:] - email_fields['version'] = workflow.manifest.version - email_fields['runName'] = run_name ?: workflow.runName - email_fields['success'] = workflow.success - email_fields['dateComplete'] = workflow.complete - email_fields['duration'] = workflow.duration - email_fields['exitStatus'] = workflow.exitStatus - email_fields['errorMessage'] = (workflow.errorMessage ?: 'None') - email_fields['errorReport'] = (workflow.errorReport ?: 'None') - email_fields['commandLine'] = workflow.commandLine - email_fields['projectDir'] = workflow.projectDir - email_fields['summary'] = summary - email_fields['summary']['Date Started'] = workflow.start - email_fields['summary']['Date Completed'] = workflow.complete - email_fields['summary']['Pipeline script file path'] = workflow.scriptFile - email_fields['summary']['Pipeline script hash ID'] = workflow.scriptId - if (workflow.repository) email_fields['summary']['Pipeline repository Git URL'] = workflow.repository - if (workflow.commitId) email_fields['summary']['Pipeline repository Git Commit'] = workflow.commitId - if (workflow.revision) email_fields['summary']['Pipeline Git branch/tag'] = workflow.revision - email_fields['summary']['Nextflow Version'] = workflow.nextflow.version - email_fields['summary']['Nextflow Build'] = workflow.nextflow.build - email_fields['summary']['Nextflow Compile Timestamp'] = workflow.nextflow.timestamp - - // On success try attach the multiqc report - def mqc_report = null - try { - if (workflow.success) { - mqc_report = multiqc_report.getVal() - if (mqc_report.getClass() == ArrayList) { - log.warn "[$workflow.manifest.name] Found multiple reports from process 'MULTIQC', will use only one" - mqc_report = mqc_report[0] - } - } - } catch (all) { - log.warn "[$workflow.manifest.name] Could not attach MultiQC report to summary email" - } - - // Check if we are only sending emails on failure - def email_address = params.email - if (!params.email && params.email_on_fail && !workflow.success) { - email_address = params.email_on_fail - } - - // Render the TXT template - def engine = new groovy.text.GStringTemplateEngine() - def tf = new File("$projectDir/assets/email_template.txt") - def txt_template = engine.createTemplate(tf).make(email_fields) - def email_txt = txt_template.toString() - - // Render the HTML template - def hf = new File("$projectDir/assets/email_template.html") - def html_template = engine.createTemplate(hf).make(email_fields) - def email_html = html_template.toString() - - // Render the sendmail template - def smail_fields = [ email: email_address, subject: subject, email_txt: email_txt, email_html: email_html, projectDir: "$projectDir", mqcFile: mqc_report, mqcMaxSize: params.max_multiqc_email_size.toBytes() ] - def sf = new File("$projectDir/assets/sendmail_template.txt") - def sendmail_template = engine.createTemplate(sf).make(smail_fields) - def sendmail_html = sendmail_template.toString() - - // Send the HTML e-mail - if (email_address) { - try { - if (params.plaintext_email) { throw GroovyException('Send plaintext e-mail, not HTML') } - // Try to send HTML e-mail using sendmail - [ 'sendmail', '-t' ].execute() << sendmail_html - log.info "[$workflow.manifest.name] Sent summary e-mail to $email_address (sendmail)" - } catch (all) { - // Catch failures and try with plaintext - def mail_cmd = [ 'mail', '-s', subject, '--content-type=text/html', email_address ] - if ( mqc_report.size() <= params.max_multiqc_email_size.toBytes() ) { - mail_cmd += [ '-A', mqc_report ] - } - mail_cmd.execute() << email_html - log.info "[$workflow.manifest.name] Sent summary e-mail to $email_address (mail)" - } - } - - // Write summary e-mail HTML to a file - def output_d = new File("${params.outdir}/pipeline_info/") - if (!output_d.exists()) { - output_d.mkdirs() - } - def output_hf = new File(output_d, "pipeline_report.html") - output_hf.withWriter { w -> w << email_html } - def output_tf = new File(output_d, "pipeline_report.txt") - output_tf.withWriter { w -> w << email_txt } - } - - static void summary(workflow, params, log) { - Map colors = Headers.log_colours(params.monochrome_logs) - if (workflow.stats.ignoredCount > 0 && workflow.success) { - log.info "-${colors.purple}Warning, pipeline completed, but with errored process(es) ${colors.reset}-" - log.info "-${colors.red}Number of ignored errored process(es) : ${workflow.stats.ignoredCount} ${colors.reset}-" - log.info "-${colors.green}Number of successfully ran process(es) : ${workflow.stats.succeedCount} ${colors.reset}-" - } - if (workflow.success) { - log.info "-${colors.purple}[$workflow.manifest.name]${colors.green} Pipeline completed successfully${colors.reset}-" - } else { - Checks.hostname(workflow, params, log) - log.info "-${colors.purple}[$workflow.manifest.name]${colors.red} Pipeline completed with errors${colors.reset}-" - } - } -} diff --git a/lib/Headers.groovy b/lib/Headers.groovy deleted file mode 100755 index 8fd9c8c6f..000000000 --- a/lib/Headers.groovy +++ /dev/null @@ -1,39 +0,0 @@ -/* - * This file holds several functions used to render the nf-core ANSI header. - */ - -class Headers { - - private static Map log_colours(Boolean monochrome_logs) { - Map colorcodes = [:] - colorcodes['reset'] = monochrome_logs ? '' : "\033[0m" - colorcodes['dim'] = monochrome_logs ? '' : "\033[2m" - colorcodes['black'] = monochrome_logs ? '' : "\033[0;30m" - colorcodes['green'] = monochrome_logs ? '' : "\033[0;32m" - colorcodes['yellow'] = monochrome_logs ? '' : "\033[0;33m" - colorcodes['yellow_bold'] = monochrome_logs ? '' : "\033[1;93m" - colorcodes['blue'] = monochrome_logs ? '' : "\033[0;34m" - colorcodes['purple'] = monochrome_logs ? '' : "\033[0;35m" - colorcodes['cyan'] = monochrome_logs ? '' : "\033[0;36m" - colorcodes['white'] = monochrome_logs ? '' : "\033[0;37m" - colorcodes['red'] = monochrome_logs ? '' : "\033[1;91m" - return colorcodes - } - - static String nf_core(workflow, monochrome_logs) { - Map colors = log_colours(monochrome_logs) - String.format( - """\n - -${colors.dim}----------------------------------------------------${colors.reset}- - ${colors.green},--.${colors.black}/${colors.green},-.${colors.reset} - ${colors.blue} ___ __ __ __ ___ ${colors.green}/,-._.--~\'${colors.reset} - ${colors.blue} |\\ | |__ __ / ` / \\ |__) |__ ${colors.yellow}} {${colors.reset} - ${colors.blue} | \\| | \\__, \\__/ | \\ |___ ${colors.green}\\`-._,-`-,${colors.reset} - ${colors.green}`._,._,\'${colors.reset} - ${colors.purple} ${workflow.manifest.name} v${workflow.manifest.version}${colors.reset} - -${colors.dim}----------------------------------------------------${colors.reset}- - """.stripIndent() - ) - } -} - diff --git a/lib/Schema.groovy b/lib/Schema.groovy deleted file mode 100755 index 3f69b2c52..000000000 --- a/lib/Schema.groovy +++ /dev/null @@ -1,184 +0,0 @@ -/* - * This file holds several functions used to perform JSON parameter validation, help and summary rendering for the nf-core pipeline template. - */ - -import groovy.json.JsonSlurper - -class Schema { - /* - * This method tries to read a JSON params file - */ - private static LinkedHashMap params_get(String path) { - def params_map = new LinkedHashMap() - try { - params_map = params_try(path) - } catch (Exception e) { - println "Could not read parameters settings from JSON. $e" - params_map = new LinkedHashMap() - } - return params_map - } - - /* - Method to actually read in JSON file using Groovy. - Group (as Key), values are all parameters - - Parameter1 as Key, Description as Value - - Parameter2 as Key, Description as Value - .... - Group - - - */ - private static LinkedHashMap params_try(String path) throws Exception { - - def json = new File(path).text - def Map json_params = (Map) new JsonSlurper().parseText(json).get('properties') - - /* Tree looks like this in nf-core schema - * properties <- this is what the first get('properties') gets us - group 1 - properties - description - group 2 - properties - description - group 3 - properties - description - */ - def params_map = new LinkedHashMap() - json_params.each { key, val -> - def Map group = json_params."$key".properties // Gets the property object of the group - def sub_params = new LinkedHashMap() - group.each { innerkey, value -> - sub_params.put("$innerkey", [ "$value.type", "$value.description" ]) - } - params_map.put("$key", sub_params) - } - return params_map - } - - private static Integer params_max_chars(params_map) { - Integer max_chars = 0 - for (group in params_map.keySet()) { - def params = params_map.get(group) // This gets the parameters of that particular group - for (par in params.keySet()) { - if (par.size() > max_chars) { - max_chars = par.size() - } - } - } - return max_chars - } - - private static String params_beautify(params_map) { - String output = "" - def max_chars = params_max_chars(params_map) + 1 - for (group in params_map.keySet()) { - output += group + "\n" - def params = params_map.get(group) // This gets the parameters of that particular group - for (par in params.keySet()) { - def type = "[" + params.get(par)[0] + "]" - def description = params.get(par)[1] - output+= " \u001B[1m" + par.padRight(max_chars) + "\u001B[1m" + type.padRight(10) + description + "\n" - } - output += "\n" - } - return output - } - - private static String params_help(path, command) { - String output = "Typical pipeline command:\n\n" - output += " ${command}\n\n" - output += params_beautify(params_get(path)) - } - - private static LinkedHashMap params_summary(workflow, params, run_name) { - def Map summary = [:] - if (workflow.revision) summary['Pipeline Release'] = workflow.revision - summary['Run Name'] = run_name ?: workflow.runName - summary['Design File'] = params.input - summary['Genome'] = params.genome ?: 'Not supplied' - summary['Fasta File'] = params.fasta - summary['GTF File'] = params.gtf - if (params.gene_bed) summary['Gene BED File'] = params.gene_bed - if (params.bwa_index) summary['BWA Index'] = params.bwa_index - if (params.blacklist) summary['Blacklist BED'] = params.blacklist - if (params.bwa_min_score) summary['BWA Min Score'] = params.bwa_min_score - summary['MACS2 Genome Size'] = params.macs_gsize ?: 'Not supplied' - summary['Min Consensus Reps'] = params.min_reps_consensus - if (params.macs_gsize) summary['MACS2 Narrow Peaks'] = params.narrow_peak ? 'Yes' : 'No' - if (!params.narrow_peak) summary['MACS2 Broad Cutoff'] = params.broad_cutoff - if (params.macs_fdr) summary['MACS2 FDR'] = params.macs_fdr - if (params.macs_pvalue) summary['MACS2 P-value'] = params.macs_pvalue - if (params.skip_trimming) { - summary['Trimming Step'] = 'Skipped' - } else { - summary['Trim R1'] = "$params.clip_r1 bp" - summary['Trim R2'] = "$params.clip_r2 bp" - summary["Trim 3' R1"] = "$params.three_prime_clip_r1 bp" - summary["Trim 3' R2"] = "$params.three_prime_clip_r2 bp" - summary['NextSeq Trim'] = "$params.trim_nextseq bp" - } - if (params.seq_center) summary['Sequencing Center'] = params.seq_center - summary['Fragment Size'] = "$params.fragment_size bp" - summary['Fingerprint Bins'] = params.fingerprint_bins - if (params.keep_dups) summary['Keep Duplicates'] = 'Yes' - if (params.keep_multi_map) summary['Keep Multi-mapped'] = 'Yes' - summary['Save Genome Index'] = params.save_reference ? 'Yes' : 'No' - if (params.save_trimmed) summary['Save Trimmed'] = 'Yes' - if (params.save_align_intermeds) summary['Save Intermeds'] = 'Yes' - if (params.save_macs_pileup) summary['Save MACS2 Pileup'] = 'Yes' - if (params.skip_peak_qc) summary['Skip MACS2 Peak QC'] = 'Yes' - if (params.skip_peak_annotation) summary['Skip Peak Annotation'] = 'Yes' - if (params.skip_consensus_peaks) summary['Skip Consensus Peaks'] = 'Yes' - if (params.deseq2_vst) summary['Use DESeq2 vst Transform'] = 'Yes' - if (params.skip_diff_analysis) summary['Skip Differential Analysis'] = 'Yes' - if (params.skip_fastqc) summary['Skip FastQC'] = 'Yes' - if (params.skip_picard_metrics) summary['Skip Picard Metrics'] = 'Yes' - if (params.skip_preseq) summary['Skip Preseq'] = 'Yes' - if (params.skip_plot_profile) summary['Skip plotProfile'] = 'Yes' - if (params.skip_plot_fingerprint) summary['Skip plotFingerprint'] = 'Yes' - if (params.skip_spp) summary['Skip spp'] = 'Yes' - if (params.skip_igv) summary['Skip IGV'] = 'Yes' - if (params.skip_multiqc) summary['Skip MultiQC'] = 'Yes' - summary['Max Resources'] = "$params.max_memory memory, $params.max_cpus cpus, $params.max_time time per job" - if (workflow.containerEngine) summary['Container'] = "$workflow.containerEngine - $workflow.container" - summary['Output dir'] = params.outdir - summary['Launch dir'] = workflow.launchDir - summary['Working dir'] = workflow.workDir - summary['Script dir'] = workflow.projectDir - summary['User'] = workflow.userName - if (workflow.profile.contains('awsbatch')) { - summary['AWS Region'] = params.awsregion - summary['AWS Queue'] = params.awsqueue - summary['AWS CLI'] = params.awscli - } - summary['Config Profile'] = workflow.profile - if (params.config_profile_description) summary['Config Profile Descr'] = params.config_profile_description - if (params.config_profile_contact) summary['Config Profile Contact'] = params.config_profile_contact - if (params.config_profile_url) summary['Config Profile URL'] = params.config_profile_url - summary['Config Files'] = workflow.configFiles.join(', ') - if (params.email || params.email_on_fail) { - summary['E-mail Address'] = params.email - summary['E-mail on failure'] = params.email_on_fail - summary['MultiQC maxsize'] = params.max_multiqc_email_size - } - return summary - } - - static String params_mqc_summary(summary) { - String yaml_file_text = """ - id: 'nf-core-chipseq-summary' - description: " - this information is collected when the pipeline is started." - section_name: 'nf-core/chipseq Workflow Summary' - section_href: 'https://github.com/nf-core/chipseq' - plot_type: 'html' - data: | -
- ${summary.collect { k,v -> "
$k
${v ?: 'N/A'}
" }.join("\n")} -
- """.stripIndent() - - return yaml_file_text - } -} diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index 165ec9206..ac77a8869 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -8,13 +8,27 @@ class WorkflowChipseq { // Check and validate parameters // public static void initialise(params, log) { - genomeExistsError(params, log) - macs2_warn(params, log) + if (params.genomes && params.genome && !params.genomes.containsKey(params.genome)) { + genomeExistsError(log) + } if (!params.fasta) { log.error "Genome fasta file not specified with e.g. '--fasta genome.fa' or via a detectable config file." System.exit(1) } + + if (!params.gtf && !params.gff) { + log.error "No GTF or GFF3 annotation specified! The pipeline requires at least one of these files." + System.exit(1) + } + + if (params.gtf && params.gff) { + gtfGffWarn(log) + } + + if (!params.macs_gsize) { + macsGsizeWarn(log) + } } // @@ -47,28 +61,34 @@ class WorkflowChipseq { // // Exit pipeline if incorrect --genome key provided // - private static void genomeExistsError(params, log) { - if (params.genomes && params.genome && !params.genomes.containsKey(params.genome)) { - log.error "=============================================================================\n" + - " Genome '${params.genome}' not found in any config files provided to the pipeline.\n" + - " Currently, the available genome keys are:\n" + - " ${params.genomes.keySet().join(", ")}\n" + - "===================================================================================" - System.exit(1) - } + private static void genomeExistsError(log) { + log.error "=============================================================================\n" + + " Genome '${params.genome}' not found in any config files provided to the pipeline.\n" + + " Currently, the available genome keys are:\n" + + " ${params.genomes.keySet().join(", ")}\n" + + "===================================================================================" + System.exit(1) + } + + // + // Print a warning if both GTF and GFF have been provided + // + private static void gtfGffWarn(log) { + log.warn "=============================================================================\n" + + " Both '--gtf' and '--gff' parameters have been provided.\n" + + " Using GTF file as priority.\n" + + "===================================================================================" } // // Show a big warning message if we're not running MACS // - private static void macs2_warn(params, log) { - if (!params.macs_gsize) { - def warnstring = params.genome ? "supported for '${params.genome}'" : 'supplied' - log.warn "=================================================================\n" + - " WARNING! MACS genome size parameter not $warnstring.\n" + - " Peak calling, annotation and differential analysis will be skipped.\n" + - " Please specify value for '--macs_gsize' to run these steps.\n" + - "=======================================================================" - } + private static void macsGsizeWarn(log) { + def warnstring = params.genome ? "supported for '${params.genome}'" : 'supplied' + log.warn "=================================================================\n" + + " WARNING! MACS genome size parameter not $warnstring.\n" + + " Peak calling, annotation and differential analysis will be skipped.\n" + + " Please specify value for '--macs_gsize' to run these steps.\n" + + "=======================================================================" } } diff --git a/lib/WorkflowMain.groovy b/lib/WorkflowMain.groovy index bc960fcc8..b4a6e4ccc 100755 --- a/lib/WorkflowMain.groovy +++ b/lib/WorkflowMain.groovy @@ -9,9 +9,8 @@ class WorkflowMain { // public static String citation(workflow) { return "If you use ${workflow.manifest.name} for your analysis please cite:\n\n" + - // TODO nf-core: Add Zenodo DOI for pipeline after first release - //"* The pipeline\n" + - //" https://doi.org/10.5281/zenodo.XXXXXXX\n\n" + + "* The pipeline\n" + + " https://doi.org/10.5281/zenodo.3240506\n\n" + "* The nf-core framework\n" + " https://doi.org/10.1038/s41587-020-0439-x\n\n" + "* Software dependencies\n" + diff --git a/main.nf b/main.nf index b7ca23496..f2fe7440c 100755 --- a/main.nf +++ b/main.nf @@ -20,6 +20,7 @@ nextflow.enable.dsl = 2 params.fasta = WorkflowMain.getGenomeAttribute(params, 'fasta') params.bwa_index = WorkflowMain.getGenomeAttribute(params, 'bwa') params.gtf = WorkflowMain.getGenomeAttribute(params, 'gtf') +params.gff = WorkflowMain.getGenomeAttribute(params, 'gff') params.gene_bed = WorkflowMain.getGenomeAttribute(params, 'gene_bed') params.macs_gsize = WorkflowMain.getGenomeAttribute(params, 'macs_gsize') params.blacklist = WorkflowMain.getGenomeAttribute(params, 'blacklist') diff --git a/nextflow.config b/nextflow.config index 327002c23..de649c6ee 100644 --- a/nextflow.config +++ b/nextflow.config @@ -10,25 +10,25 @@ params { // Input options input = null - seq_center = '' + seq_center = null fragment_size = 200 fingerprint_bins = 500000 // References - genome = false + genome = null save_reference = false // Options: Trimming - clip_r1 = 0 - clip_r2 = 0 - three_prime_clip_r1 = 0 - three_prime_clip_r2 = 0 - trim_nextseq = 0 + clip_r1 = null + clip_r2 = null + three_prime_clip_r1 = null + three_prime_clip_r2 = null + trim_nextseq = null skip_trimming = false save_trimmed = false // Options: Alignments - bwa_min_score = false + bwa_min_score = null keep_dups = false keep_multi_map = false save_align_intermeds = false @@ -36,8 +36,8 @@ params { // Options: Peaks narrow_peak = false broad_cutoff = 0.1 - macs_fdr = false - macs_pvalue = false + macs_fdr = null + macs_pvalue = null min_reps_consensus = 1 save_macs_pileup = false skip_peak_qc = false @@ -59,42 +59,29 @@ params { skip_multiqc = false // Options: Config - multiqc_config = false bamtools_filter_pe_config = "$projectDir/assets/bamtools_filter_pe.json" bamtools_filter_se_config = "$projectDir/assets/bamtools_filter_se.json" - // Options: Custom config - custom_config_version = 'master' - custom_config_base = "https://raw.githubusercontent.com/nf-core/configs/${params.custom_config_version}" - config_profile_description = false - config_profile_contact = false - config_profile_url = false - // Boilerplate options - help = false outdir = './results' publish_dir_mode = 'copy' - igenomes_base = 's3://ngi-igenomes/igenomes/' - igenomes_ignore = false - max_multiqc_email_size = 25.MB - tracedir = "${params.outdir}/pipeline_info" - email = false - email_on_fail = false + multiqc_config = null + multiqc_title = null + email = null + email_on_fail = null + max_multiqc_email_size = '25.MB' plaintext_email = false monochrome_logs = false - // name = false // TODO remove parameter - hostnames = false + help = false + igenomes_base = 's3://ngi-igenomes/igenomes' + tracedir = "${params.outdir}/pipeline_info" + igenomes_ignore = false validate_params = true show_hidden_params = false schema_ignore_params = 'genomes,modules' enable_conda = false singularity_pull_docker_container = false - - // MultiQC options - multiqc_config = null - multiqc_title = null - max_multiqc_email_size = '25.MB' - + // name = false // TODO remove parameter // Config options custom_config_version = 'master' diff --git a/nextflow_schema.json b/nextflow_schema.json index 1024fcdce..7067f0d60 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -21,7 +21,7 @@ "pattern": "^\\S+\\.csv$", "schema": "assets/schema_input.json", "description": "Path to comma-separated file containing information about the samples in the experiment.", - "help_text": "You will need to create a design file with information about the samples in your experiment before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 6 columns, and a header row. See [usage docs](https://nf-co.re/chipseq/docs/usage#introduction).", + "help_text": "You will need to create a design file with information about the samples in your experiment before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 5 columns, and a header row. See [usage docs](https://nf-co.re/chipseq/docs/usage#introduction).", "fa_icon": "fas fa-file-csv" }, "fragment_size": { diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 05d242c0f..c29dad052 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -13,32 +13,15 @@ WorkflowChipseq.initialise(params, log) def checkPathParamList = [ params.input, params.multiqc_config, params.fasta, - params.gtf, params.gene_bed, + params.gtf, params.gff, params.gene_bed, params.bwa_index, params.blacklist, params.bamtools_filter_pe_config, params.bamtools_filter_se_config ] - for (param in checkPathParamList) { if (param) { file(param, checkIfExists: true) } } -// Check mandatory parameters -if (params.input) { ch_input = file(params.input) } else { exit 1, 'Input samplesheet not specified!' } - -// Check fasta reference file -if (params.fasta) { ch_fasta = file(params.fasta, checkIfExists: true) } else { exit 1, 'Fasta file not specified!' } - -// Check gtf annotation file -if (params.gtf) { ch_gtf = file(params.gtf, checkIfExists: true) } else { exit 1, 'GTF annotation file not specified!' } - -// Check bed annotation file -if (params.gene_bed) { ch_gene_bed = file(params.gene_bed, checkIfExists: true) } - -// Check bed blacklist file -if (params.blacklist) { - ch_blacklist = Channel.fromPath(params.blacklist, checkIfExists: true) -} else { - ch_blacklist = Channel.empty() -} +// Check blacklist file +ch_blacklist = params.blacklist ? file(params.blacklist) : Channel.empty() // Save AWS IGenomes file containing annotation version def anno_readme = params.genomes[ params.genome ]?.readme @@ -68,21 +51,19 @@ def peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' ch_multiqc_config = file("$projectDir/assets/multiqc_config.yaml", checkIfExists: true) ch_multiqc_custom_config = params.multiqc_config ? Channel.fromPath(params.multiqc_config) : Channel.empty() -ch_output_docs = file("$projectDir/docs/output.md", checkIfExists: true) -ch_output_docs_images = file("$projectDir/docs/images/", checkIfExists: true) // JSON files required by BAMTools for alignment filtering ch_bamtools_filter_se_config = file(params.bamtools_filter_se_config, checkIfExists: true) ch_bamtools_filter_pe_config = file(params.bamtools_filter_pe_config, checkIfExists: true) // Header files for MultiQC -ch_spp_nsc_header = file("$projectDir/assets/multiqc/spp_nsc_header.txt", checkIfExists: true) -ch_spp_rsc_header = file("$projectDir/assets/multiqc/spp_rsc_header.txt", checkIfExists: true) -ch_spp_correlation_header = file("$projectDir/assets/multiqc/spp_correlation_header.txt", checkIfExists: true) -ch_peak_count_header = file("$projectDir/assets/multiqc/peak_count_header.txt", checkIfExists: true) -ch_frip_score_header = file("$projectDir/assets/multiqc/frip_score_header.txt", checkIfExists: true) -ch_peak_annotation_header = file("$projectDir/assets/multiqc/peak_annotation_header.txt", checkIfExists: true) -ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) +ch_spp_nsc_header = file("$projectDir/assets/multiqc/spp_nsc_header.txt", checkIfExists: true) +ch_spp_rsc_header = file("$projectDir/assets/multiqc/spp_rsc_header.txt", checkIfExists: true) +ch_spp_correlation_header = file("$projectDir/assets/multiqc/spp_correlation_header.txt", checkIfExists: true) +ch_peak_count_header = file("$projectDir/assets/multiqc/peak_count_header.txt", checkIfExists: true) +ch_frip_score_header = file("$projectDir/assets/multiqc/frip_score_header.txt", checkIfExists: true) +ch_peak_annotation_header = file("$projectDir/assets/multiqc/peak_annotation_header.txt", checkIfExists: true) +ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) /* @@ -115,12 +96,9 @@ include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_home include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' addParams( options: plot_macs2_qc_options ) include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' addParams( options: macs2_consensus_options ) include { FRIP_SCORE } from '../modules/local/frip_score' addParams( options: modules['frip_score'] ) -//include { DESEQ2_FEATURECOUNTS } from '../modules/local/deseq2_featurecounts' addParams( options: [:] ) +//include { DESEQ2_QC } from '../modules/local/deseq2_qc' addParams( options: deseq2_qc_options, multiqc_label: 'star_salmon' ) include { IGV } from '../modules/local/igv' addParams( options: [:] ) include { OUTPUT_DOCUMENTATION } from '../modules/local/output_documentation' addParams( options: [:] ) -// include { GET_SOFTWARE_VERSIONS } from '../modules/local/get_software_versions' addParams( options: modules['get_software_versions'] ) -// TODO template version below to be removed when checked -// include { GET_SOFTWARE_VERSIONS } from '../modules/local/get_software_versions' addParams( options: [publish_files : ['tsv':'']] ) include { MULTIQC } from '../modules/local/multiqc' addParams( options: multiqc_options ) include { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS } from '../modules/local/multiqc_custom_phantompeakqualtools' addParams( options: modules['multiqc_custom_phantompeakqualtools'] ) include { MULTIQC_CUSTOM_PEAKS } from '../modules/local/multiqc_custom_peaks' addParams( options: modules['multiqc_custom_peaks'] ) @@ -205,7 +183,7 @@ workflow CHIPSEQ { // SUBWORKFLOW: Read in samplesheet, validate and stage input files // INPUT_CHECK ( - ch_input, + file(params.input), params.seq_center, [:] ) From 960b60b3504e7168a350d9482e5e3e0cfdf180df Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Sun, 24 Oct 2021 09:34:46 +0100 Subject: [PATCH 207/538] Update samplesheet path in test-datasets --- conf/test.config | 2 +- conf/test_full.config | 2 +- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/conf/test.config b/conf/test.config index 948346acc..c5c232d96 100644 --- a/conf/test.config +++ b/conf/test.config @@ -20,7 +20,7 @@ params { max_time = 6.h // Input data - input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/design.csv' + input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/samplesheet/v2.0/samplesheet_test.csv' // Genome references fasta = 'https://raw.githubusercontent.com/nf-core/test-datasets/atacseq/reference/genome.fa' diff --git a/conf/test_full.config b/conf/test_full.config index ae90a3c6a..452900719 100644 --- a/conf/test_full.config +++ b/conf/test_full.config @@ -15,7 +15,7 @@ params { config_profile_description = 'Full test dataset to check pipeline function' // Input data for full size test - input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/design_full.csv' + input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/samplesheet/v2.0/samplesheet_full.csv' // Genome references genome = 'hg19' From 608fe2aa2e7dbf0637e7bad1ceaf1b2b2b5e2e13 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Sun, 24 Oct 2021 10:32:15 +0100 Subject: [PATCH 208/538] Get tests workfing with new samplesheet format --- bin/check_samplesheet.py | 91 ++-- bin/check_samplesheet_old.py | 173 ------- lib/WorkflowChipseq.groovy | 8 +- modules/local/samplesheet_check.nf | 21 +- subworkflows/local/input_check.nf | 44 +- workflows/chipseq.nf | 784 ++++++++++++++--------------- 6 files changed, 486 insertions(+), 635 deletions(-) delete mode 100755 bin/check_samplesheet_old.py diff --git a/bin/check_samplesheet.py b/bin/check_samplesheet.py index 91327e5c6..cab38cff6 100755 --- a/bin/check_samplesheet.py +++ b/bin/check_samplesheet.py @@ -7,7 +7,7 @@ def parse_args(args=None): - Description = "Reformat nf-core/rnaseq samplesheet file and check its contents." + Description = "Reformat nf-core/chipseq samplesheet file and check its contents." Epilog = "Example usage: python check_samplesheet.py " parser = argparse.ArgumentParser(description=Description, epilog=Epilog) @@ -37,21 +37,22 @@ def check_samplesheet(file_in, file_out): """ This function checks that the samplesheet follows the following structure: - sample,fastq_1,fastq_2,strandedness - SAMPLE_PE,SAMPLE_PE_RUN1_1.fastq.gz,SAMPLE_PE_RUN1_2.fastq.gz,forward - SAMPLE_PE,SAMPLE_PE_RUN2_1.fastq.gz,SAMPLE_PE_RUN2_2.fastq.gz,forward - SAMPLE_SE,SAMPLE_SE_RUN1_1.fastq.gz,,forward + sample,fastq_1,fastq_2,antibody,control + SPT5_T0_REP1,SRR1822153_1.fastq.gz,SRR1822153_2.fastq.gz,SPT5,SPT5_INPUT_REP1 + SPT5_T0_REP2,SRR1822154_1.fastq.gz,SRR1822154_2.fastq.gz,SPT5,SPT5_INPUT_REP2 + SPT5_INPUT_REP1,SRR5204809_Spt5-ChIP_Input1_SacCer_ChIP-Seq_ss100k_R1.fastq.gz,SRR5204809_Spt5-ChIP_Input1_SacCer_ChIP-Seq_ss100k_R2.fastq.gz,, + SPT5_INPUT_REP2,SRR5204810_Spt5-ChIP_Input2_SacCer_ChIP-Seq_ss100k_R1.fastq.gz,SRR5204810_Spt5-ChIP_Input2_SacCer_ChIP-Seq_ss100k_R2.fastq.gz,, For an example see: - https://github.com/nf-core/test-datasets/blob/rnaseq/samplesheet/v3.1/samplesheet_test.csv + https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/samplesheet/v2.0/samplesheet_test.csv """ sample_mapping_dict = {} - with open(file_in, "r", encoding='utf-8-sig') as fin: + with open(file_in, "r", encoding="utf-8-sig") as fin: ## Check header - MIN_COLS = 3 - HEADER = ["sample", "fastq_1", "fastq_2", "strandedness"] + MIN_COLS = 2 + HEADER = ["sample", "fastq_1", "fastq_2", "antibody", "control"] header = [x.strip('"') for x in fin.readline().strip().split(",")] if header[: len(HEADER)] != HEADER: print( @@ -80,7 +81,7 @@ def check_samplesheet(file_in, file_out): ) ## Check sample name entries - sample, fastq_1, fastq_2, strandedness = lspl[: len(HEADER)] + sample, fastq_1, fastq_2, antibody, control = lspl[: len(HEADER)] if sample.find(" ") != -1: print( f"WARNING: Spaces have been replaced by underscores for sample: {sample}" @@ -101,32 +102,42 @@ def check_samplesheet(file_in, file_out): line, ) - ## Check strandedness - strandednesses = ["unstranded", "forward", "reverse"] - if strandedness: - if strandedness not in strandednesses: + ## Check antibody and control columns have valid values + if antibody: + if antibody.find(" ") != -1: + print( + f"WARNING: Spaces have been replaced by underscores for antibody: {antibody}" + ) + antibody = antibody.replace(" ", "_") + if not control: print_error( - f"Strandedness must be one of '{', '.join(strandednesses)}'!", + "Both antibody and control columns must be specified!", + "Line", + line, + ) + if control: + if control.find(" ") != -1: + print( + f"WARNING: Spaces have been replaced by underscores for control: {control}" + ) + control = control.replace(" ", "_") + if not antibody: + print_error( + "Both antibody and control columns must be specified!", "Line", line, ) - else: - print_error( - f"Strandedness has not been specified! Must be one of {', '.join(strandednesses)}.", - "Line", - line, - ) ## Auto-detect paired-end/single-end - sample_info = [] ## [single_end, fastq_1, fastq_2, strandedness] + sample_info = [] ## [single_end, fastq_1, fastq_2, antibody, control] if sample and fastq_1 and fastq_2: ## Paired-end short reads - sample_info = ["0", fastq_1, fastq_2, strandedness] + sample_info = ["0", fastq_1, fastq_2, antibody, control] elif sample and fastq_1 and not fastq_2: ## Single-end short reads - sample_info = ["1", fastq_1, fastq_2, strandedness] + sample_info = ["1", fastq_1, fastq_2, antibody, control] else: print_error("Invalid combination of columns provided!", "Line", line) - ## Create sample mapping dictionary = {sample: [[ single_end, fastq_1, fastq_2, strandedness ]]} + ## Create sample mapping dictionary = {sample: [[ single_end, fastq_1, fastq_2, antibody, control ]]} if sample not in sample_mapping_dict: sample_mapping_dict[sample] = [sample_info] else: @@ -141,7 +152,16 @@ def check_samplesheet(file_in, file_out): make_dir(out_dir) with open(file_out, "w") as fout: fout.write( - ",".join(["sample", "single_end", "fastq_1", "fastq_2", "strandedness"]) + ",".join( + [ + "sample", + "single_end", + "fastq_1", + "fastq_2", + "antibody", + "control", + ] + ) + "\n" ) for sample in sorted(sample_mapping_dict.keys()): @@ -157,18 +177,15 @@ def check_samplesheet(file_in, file_out): sample, ) - ## Check that multiple runs of the same sample are of the same strandedness - if not all( - x[-1] == sample_mapping_dict[sample][0][-1] - for x in sample_mapping_dict[sample] - ): - print_error( - f"Multiple runs of a sample must have the same strandedness!", - "Sample", - sample, - ) - for idx, val in enumerate(sample_mapping_dict[sample]): + control = val[-1] + if control and control not in sample_mapping_dict.keys(): + print_error( + f"Control identifier has to match does a provided sample identifier!", + "Control", + control, + ) + fout.write(",".join([f"{sample}_T{idx+1}"] + val) + "\n") else: print_error(f"No entries to process!", "Samplesheet: {file_in}") diff --git a/bin/check_samplesheet_old.py b/bin/check_samplesheet_old.py deleted file mode 100755 index fdbee3889..000000000 --- a/bin/check_samplesheet_old.py +++ /dev/null @@ -1,173 +0,0 @@ -#!/usr/bin/env python3 - -import os -import sys -import errno -import argparse - - -def parse_args(args=None): - Description = "Reformat nf-core/chipseq samplesheet file and check its contents." - Epilog = "Example usage: python check_samplesheet.py " - - parser = argparse.ArgumentParser(description=Description, epilog=Epilog) - parser.add_argument("FILE_IN", help="Input samplesheet file.") - parser.add_argument("FILE_OUT", help="Output file.") - return parser.parse_args(args) - - -def make_dir(path): - if len(path) > 0: - try: - os.makedirs(path) - except OSError as exception: - if exception.errno != errno.EEXIST: - raise exception - - -def print_error(error, context='Line', context_str=''): - error_str = "ERROR: Please check samplesheet -> {}".format(error) - if context != '' and context_str != '': - error_str = "ERROR: Please check samplesheet -> {}\n{}: '{}'".format(error, context.strip(), context_str.strip()) - print(error_str) - sys.exit(1) - - -def check_samplesheet(file_in, file_out): - """ - This function checks that the samplesheet follows the following structure: - - group,replicate,fastq_1,fastq_2,antibody,control - CTCF_IP,1,CTCF_IP_1.fastq.gz,CTCF_IP_2.fastq.gz,CTCF,INPUT - INPUT,1,INPUT_1.fastq.gz,INPUT_IP_2.fastq.gz,, - """ - - sample_run_dict = {} - antibody_dict = {} - with open(file_in, "r") as fin: - - ## Check header - HEADER = ['group', 'replicate', 'fastq_1', 'fastq_2', 'antibody', 'control'] - header = fin.readline().strip().split(",") - if header != HEADER: - print("ERROR: Please check samplesheet header -> {} != {}".format(",".join(header), ",".join(HEADER))) - sys.exit(1) - - ## Check sample entries - for line in fin: - lspl = [x.strip() for x in line.strip().split(",")] - sample, replicate, fastq_1, fastq_2, antibody, control = lspl - - ## Check valid number of columns per row - if len(lspl) != len(header): - print_error("Invalid number of columns (minimum = {})!".format(len(header)), 'Line', line) - - num_cols = len([x for x in lspl if x]) - if num_cols < 3: - print_error("Invalid number of populated columns (minimum = 3)!", 'Line', line) - - ## Check sample name entries - if sample: - if sample.find(" ") != -1: - print_error("Group entry contains spaces!", 'Line', line) - else: - print_error("Group entry has not been specified!", 'Line', line) - - ## Check replicate entry is integer - if not replicate.isdigit(): - print_error("Replicate id not an integer!", 'Line', line) - replicate = int(replicate) - - ## Check FastQ file extension - for fastq in [fastq_1, fastq_2]: - if fastq: - if fastq.find(" ") != -1: - print_error("FastQ file contains spaces!", 'Line', line) - if not fastq.endswith(".fastq.gz") and not fastq.endswith(".fq.gz"): - print_error("FastQ file does not have extension '.fastq.gz' or '.fq.gz'!", 'Line', line) - - ## Check antibody and control columns have valid values - if antibody: - if antibody.find(' ') != -1: - print_error("Antibody id contains spaces!", line) - if not control: - print_error("Both antibody and control columns must be specified!", 'Line', line) - if control: - if control.find(' ') != -1: - print_error("Control id contains spaces!", line) - if not antibody: - print_error("Both antibody and control columns must be specified!", 'Line', line) - if antibody and control: - antibody_dict[sample] = (antibody,control) - - ## Auto-detect paired-end/single-end - sample_info = [] ## [single_end, fastq_1, fastq_2] - if sample and fastq_1 and fastq_2: ## Paired-end short reads - sample_info = ["0", fastq_1, fastq_2] - elif sample and fastq_1 and not fastq_2: ## Single-end short reads - sample_info = ["1", fastq_1, fastq_2] - else: - print_error("Invalid combination of columns provided!", 'Line', line) - - ## Create sample mapping dictionary = {sample: {replicate : [ single_end, fastq_1, fastq_2 ]}} - if sample not in sample_run_dict: - sample_run_dict[sample] = {} - if replicate not in sample_run_dict[sample]: - sample_run_dict[sample][replicate] = [sample_info] - else: - if sample_info in sample_run_dict[sample][replicate]: - print_error("Samplesheet contains duplicate rows!", 'Line', line) - else: - sample_run_dict[sample][replicate].append(sample_info) - - ## Check if antibody and control columns have been specified at least once - if len(antibody_dict) == 0: - print_error("Antibody and control must be specified at least once!", '', '') - - ## Write validated samplesheet with appropriate columns - antibody_group_dict = {} - if len(sample_run_dict) > 0: - out_dir = os.path.dirname(file_out) - make_dir(out_dir) - with open(file_out, "w") as fout: - - fout.write(",".join(["sample", "single_end", "fastq_1", "fastq_2", "antibody", "control"]) + "\n") - for sample in sorted(sample_run_dict.keys()): - - ## Check that replicate ids are in format 1.. - uniq_rep_ids = set(sample_run_dict[sample].keys()) - if len(uniq_rep_ids) != max(uniq_rep_ids): - print_error("Replicate IDs must start with 1..!", 'Group', sample) - - for replicate in sorted(sample_run_dict[sample].keys()): - - ## Check that multiple runs of the same sample are of the same datatype - if not all(x[0] == sample_run_dict[sample][replicate][0][0] for x in sample_run_dict[sample][replicate]): - print_error("Multiple runs of a sample must be of the same datatype!", 'Group', sample) - - for idx, sample_info in enumerate(sample_run_dict[sample][replicate]): - sample_id = "{}_R{}_T{}".format(sample,replicate,idx+1) - oList = [sample_id] + sample_info - - ## Extrapolate group column - if sample in antibody_dict: - antibody,control = antibody_dict[sample] - if control in sample_run_dict.keys(): - control_id = "{}_R1".format(control) - if replicate in sample_run_dict[control]: - control_id = "{}_R{}".format(control,replicate) - oList += [antibody, control_id] - else: - print_error("Control id not a valid group: {}!".format(control), 'Valid Groups', sorted(sample_run_dict.keys())) - else: - oList += 2 * [''] - fout.write(','.join(oList) + '\n') - - -def main(args=None): - args = parse_args(args) - check_samplesheet(args.FILE_IN, args.FILE_OUT) - - -if __name__ == "__main__": - sys.exit(main()) diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index ac77a8869..7c89baf76 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -9,7 +9,7 @@ class WorkflowChipseq { // public static void initialise(params, log) { if (params.genomes && params.genome && !params.genomes.containsKey(params.genome)) { - genomeExistsError(log) + genomeExistsError(params, log) } if (!params.fasta) { @@ -27,7 +27,7 @@ class WorkflowChipseq { } if (!params.macs_gsize) { - macsGsizeWarn(log) + macsGsizeWarn(params, log) } } @@ -61,7 +61,7 @@ class WorkflowChipseq { // // Exit pipeline if incorrect --genome key provided // - private static void genomeExistsError(log) { + private static void genomeExistsError(params, log) { log.error "=============================================================================\n" + " Genome '${params.genome}' not found in any config files provided to the pipeline.\n" + " Currently, the available genome keys are:\n" + @@ -83,7 +83,7 @@ class WorkflowChipseq { // // Show a big warning message if we're not running MACS // - private static void macsGsizeWarn(log) { + private static void macsGsizeWarn(params, log) { def warnstring = params.genome ? "supported for '${params.genome}'" : 'supplied' log.warn "=================================================================\n" + " WARNING! MACS genome size parameter not $warnstring.\n" + diff --git a/modules/local/samplesheet_check.nf b/modules/local/samplesheet_check.nf index 5d0ead4dc..533d149e5 100644 --- a/modules/local/samplesheet_check.nf +++ b/modules/local/samplesheet_check.nf @@ -1,26 +1,29 @@ -//TODO Update with rnaseq 3.3 version // Import generic module functions include { saveFiles; getProcessName } from './functions' -/* - * Reformat design file, check validitiy and create IP vs control mappings - */ +params.options = [:] + process SAMPLESHEET_CHECK { tag "$samplesheet" publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:options, publish_dir:"pipeline_info", publish_id:'') } + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'pipeline_info', meta:[:], publish_by_meta:[]) } - conda (params.enable_conda ? "${baseDir}/environment.yml" : null) + conda (params.enable_conda ? "conda-forge::python=3.8.3" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://depot.galaxyproject.org/singularity/python:3.8.3" + } else { + container "quay.io/biocontainers/python:3.8.3" + } input: path samplesheet - val options output: - path '*.csv' + path '*.csv' , emit: csv + path "versions.yml", emit: versions - script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ """ check_samplesheet.py \\ $samplesheet \\ diff --git a/subworkflows/local/input_check.nf b/subworkflows/local/input_check.nf index fca645273..a20214b73 100644 --- a/subworkflows/local/input_check.nf +++ b/subworkflows/local/input_check.nf @@ -6,44 +6,48 @@ params.options = [:] include { SAMPLESHEET_CHECK } from '../../modules/local/samplesheet_check' addParams( options: params.options ) -/* - * Check input samplesheet and get read channels - */ workflow INPUT_CHECK { take: - ch_input // file: /path/to/samplesheet.csv - seq_center // string: sequencing center for read group - samplesheet_check_options // map: options for check_samplesheet module + samplesheet // file: /path/to/samplesheet.csv + seq_center // string: sequencing center for read group main: - SAMPLESHEET_CHECK (ch_input, samplesheet_check_options) - .splitCsv(header:true, sep:',') - .map { get_samplesheet_paths(it, seq_center) } - .set { ch_reads } + SAMPLESHEET_CHECK ( samplesheet ) + .csv + .splitCsv ( header:true, sep:',' ) + .map { create_fastq_channel(it, seq_center) } + .set { reads } emit: - reads = ch_reads // channel: [ val(meta), [ reads ] ] + reads // channel: [ val(meta), [ reads ] ] + versions = SAMPLESHEET_CHECK.out.versions // channel: [ versions.yml ] } // Function to get list of [ meta, [ fastq_1, fastq_2 ] ] -def get_samplesheet_paths(LinkedHashMap row, String seq_center) { +def create_fastq_channel(LinkedHashMap row, String seq_center) { def meta = [:] - meta.id = row.sample + meta.id = row.sample meta.single_end = row.single_end.toBoolean() - meta.antibody = row.antibody - meta.control = row.control + meta.antibody = row.antibody + meta.control = row.control - def rg = "\'@RG\\tID:${meta.id}\\tSM:${meta.id.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${meta.id}\\tPU:1\'" + def read_group = "\'@RG\\tID:${meta.id}\\tSM:${meta.id.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${meta.id}\\tPU:1\'" if (seq_center) { - rg = "\'@RG\\tID:${meta.id}\\tSM:${meta.id.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${meta.id}\\tPU:1\\tCN:${seq_center}\'" + read_group = "\'@RG\\tID:${meta.id}\\tSM:${meta.id.split('_')[0..-2].join('_')}\\tPL:ILLUMINA\\tLB:${meta.id}\\tPU:1\\tCN:${seq_center}\'" } - meta.read_group = rg + meta.read_group = read_group def array = [] + if (!file(row.fastq_1).exists()) { + exit 1, "ERROR: Please check input samplesheet -> Read 1 FastQ file does not exist!\n${row.fastq_1}" + } if (meta.single_end) { - array = [ meta, [ file(row.fastq_1, checkIfExists: true) ] ] + array = [ meta, [ file(row.fastq_1) ] ] } else { - array = [ meta, [ file(row.fastq_1, checkIfExists: true), file(row.fastq_2, checkIfExists: true) ] ] + if (!file(row.fastq_2).exists()) { + exit 1, "ERROR: Please check input samplesheet -> Read 2 FastQ file does not exist!\n${row.fastq_2}" + } + array = [ meta, [ file(row.fastq_1), file(row.fastq_2) ] ] } return array } diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index c29dad052..43186bbd6 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -156,15 +156,15 @@ include { MACS2_CALLPEAK } from '../modules/nf-core/modules/macs2 include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/modules/subread/featurecounts/main' addParams( options: subread_featurecounts_options ) include { CUSTOM_DUMPSOFTWAREVERSIONS } from '../modules/nf-core/modules/custom/dumpsoftwareversions/main' addParams( options: [publish_files : ['_versions.yml':'']] ) -include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_macs2_options ) +include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_macs2_options ) include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_consensus_options ) // // SUBWORKFLOW: Consisting entirely of nf-core/modules // -include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' addParams( fastqc_options: modules['fastqc'], trimgalore_options: modules['trimgalore'] ) -include { MAP_BWA_MEM } from '../subworkflows/nf-core/map_bwa_mem' addParams( bwa_mem_options: modules['bwa_mem'], samtools_sort_options: modules['samtools_sort_lib'], samtools_index_options: modules['samtools_sort_lib'], samtools_stats_options: modules['samtools_sort_lib'] ) -include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' addParams( markduplicates_options: modules['picard_markduplicates'], samtools_index_options: modules['samtools_sort_merged_lib'] , samtools_stats_options: modules['samtools_sort_merged_lib'] ) +include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' addParams( fastqc_options: modules['fastqc'], trimgalore_options: modules['trimgalore'] ) +include { MAP_BWA_MEM } from '../subworkflows/nf-core/map_bwa_mem' addParams( bwa_mem_options: modules['bwa_mem'], samtools_sort_options: modules['samtools_sort_lib'], samtools_index_options: modules['samtools_sort_lib'], samtools_stats_options: modules['samtools_sort_lib'] ) +include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' addParams( markduplicates_options: modules['picard_markduplicates'], samtools_index_options: modules['samtools_sort_merged_lib'] , samtools_stats_options: modules['samtools_sort_merged_lib'] ) /* ======================================================================================== @@ -184,410 +184,410 @@ workflow CHIPSEQ { // INPUT_CHECK ( file(params.input), - params.seq_center, - [:] + params.seq_center ) - - // - // MODULE: Run FastQC - // - // TODO check if this fastqc process from nf-core is needed Don't think so done in FASTQC_TRIMGALORE - // FASTQC ( - // INPUT_CHECK.out.reads + ch_versions = ch_versions.mix(INPUT_CHECK.out.versions) + + // // + // // MODULE: Run FastQC + // // + // // TODO check if this fastqc process from nf-core is needed Don't think so done in FASTQC_TRIMGALORE + // // FASTQC ( + // // INPUT_CHECK.out.reads + // // ) + // // ch_software_versions = ch_software_versions.mix(FASTQC.out.versions.first().ifEmpty(null)) + + // // + // // SUBWORKFLOW: Prepare genome files + // // + // ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta ).index + + // if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf ) } + + // MAKE_GENOME_FILTER ( + // GET_CHROM_SIZES ( ch_fasta ).sizes, + // ch_blacklist.ifEmpty([]) + // ) + // // ch_software_versions = Channel.empty() + // // ch_software_versions = ch_software_versions.mix(MAKE_GENOME_FILTER.out.versions.first().ifEmpty(null)) + // ch_versions = ch_versions.mix(MAKE_GENOME_FILTER.out.versions) + + // // + // // SUBWORKFLOW: Read QC & trimming + // // + // nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' + // params.modules['trimgalore'].args += nextseq + // FASTQC_TRIMGALORE ( + // INPUT_CHECK.out.reads, + // params.skip_fastqc, + // params.skip_trimming + // ) + // // ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.fastqc_versions.first().ifEmpty(null)) + // ch_versions = ch_versions.mix(FASTQC_TRIMGALORE.out.versions) + + // // + // // SUBWORKFLOW: Map reads & BAM QC + // // + // score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' + // params.modules['bwa_mem'].args += score + // MAP_BWA_MEM ( + // FASTQC_TRIMGALORE.out.reads, + // ch_index + // ) + // // ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.bwa_versions.first()) + // // ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.samtools_versions.first().ifEmpty(null)) + // ch_versions = ch_versions.mix(MAP_BWA_MEM.out.versions) + + // // + // // SUBWORKFLOW: Merge resequenced BAM files + // // + // MAP_BWA_MEM + // .out + // .bam + // .map { + // meta, bam -> + // fmeta = meta.findAll { it.key != 'read_group' } + // fmeta.id = fmeta.id.split('_')[0..-2].join('_') + // [ fmeta, bam ] } + // .groupTuple(by: [0]) + // .map { it -> [ it[0], it[1].flatten() ] } + // .set { ch_sort_bam } + + // PICARD_MERGESAMFILES ( + // ch_sort_bam + // ) + // // ch_software_versions = ch_software_versions.mix(PICARD_MERGESAMFILES.out.versions.first().ifEmpty(null)) + // ch_versions = ch_versions.mix(PICARD_MERGESAMFILES.out.versions) + + // // + // // SUBWORKFLOW: Mark duplicates & filter BAM files + // // + // MARK_DUPLICATES_PICARD ( + // PICARD_MERGESAMFILES.out.bam // ) - // ch_software_versions = ch_software_versions.mix(FASTQC.out.versions.first().ifEmpty(null)) - - // - // SUBWORKFLOW: Prepare genome files - // - ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta ).index - - if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf ) } - - MAKE_GENOME_FILTER ( - GET_CHROM_SIZES ( ch_fasta ).sizes, - ch_blacklist.ifEmpty([]) - ) - // ch_software_versions = Channel.empty() - // ch_software_versions = ch_software_versions.mix(MAKE_GENOME_FILTER.out.versions.first().ifEmpty(null)) - ch_versions = ch_versions.mix(MAKE_GENOME_FILTER.out.versions) - - // - // SUBWORKFLOW: Read QC & trimming - // - nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' - params.modules['trimgalore'].args += nextseq - FASTQC_TRIMGALORE ( - INPUT_CHECK.out.reads, - params.skip_fastqc, - params.skip_trimming - ) - // ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.fastqc_versions.first().ifEmpty(null)) - ch_versions = ch_versions.mix(FASTQC_TRIMGALORE.out.versions) - - // - // SUBWORKFLOW: Map reads & BAM QC - // - score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' - params.modules['bwa_mem'].args += score - MAP_BWA_MEM ( - FASTQC_TRIMGALORE.out.reads, - ch_index - ) - // ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.bwa_versions.first()) - // ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.samtools_versions.first().ifEmpty(null)) - ch_versions = ch_versions.mix(MAP_BWA_MEM.out.versions) - - // - // SUBWORKFLOW: Merge resequenced BAM files - // - MAP_BWA_MEM - .out - .bam - .map { - meta, bam -> - fmeta = meta.findAll { it.key != 'read_group' } - fmeta.id = fmeta.id.split('_')[0..-2].join('_') - [ fmeta, bam ] } - .groupTuple(by: [0]) - .map { it -> [ it[0], it[1].flatten() ] } - .set { ch_sort_bam } - - PICARD_MERGESAMFILES ( - ch_sort_bam - ) - // ch_software_versions = ch_software_versions.mix(PICARD_MERGESAMFILES.out.versions.first().ifEmpty(null)) - ch_versions = ch_versions.mix(PICARD_MERGESAMFILES.out.versions) - - // - // SUBWORKFLOW: Mark duplicates & filter BAM files - // - MARK_DUPLICATES_PICARD ( - PICARD_MERGESAMFILES.out.bam - ) - - // - // SUBWORKFLOW: Fix getting name sorted BAM here for PE/SE - // - BAM_CLEAN ( - MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), - MAKE_GENOME_FILTER.out.bed.collect(), - ch_bamtools_filter_se_config, - ch_bamtools_filter_pe_config - ) - // ch_software_versions = ch_software_versions.mix(BAM_CLEAN.out.bamtools_versions.first().ifEmpty(null)) - ch_versions = ch_versions.mix(BAM_CLEAN.out.versions) - - // - // MODULE: Post alignment QC - // - PICARD_COLLECTMULTIPLEMETRICS ( - BAM_CLEAN.out.bam, - ch_fasta - ) - - // TODO Add versions to picard collectmultiplemetrics - - // - // MODULE: Library coverage - // - PRESEQ_LCEXTRAP ( - BAM_CLEAN.out.bam - ) - // ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.versions.first().ifEmpty(null)) - ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions) - - // - // MODULE: Strand cross-correlation - // - PHANTOMPEAKQUALTOOLS ( - BAM_CLEAN.out.bam - ) - // ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions.first().ifEmpty(null)) - ch_versions = ch_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions) - - MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( - PHANTOMPEAKQUALTOOLS.out.spp.join(PHANTOMPEAKQUALTOOLS.out.rdata, by: [0]), - ch_spp_nsc_header, - ch_spp_rsc_header, - ch_spp_correlation_header - ) - - // - // MODULE: Coverage tracks - // - BEDTOOLS_GENOMECOV ( - BAM_CLEAN.out.bam.join(BAM_CLEAN.out.flagstat, by: [0]) - ) - // - // MODULE: Coverage tracks - // - UCSC_BEDGRAPHTOBIGWIG ( - BEDTOOLS_GENOMECOV.out.bedgraph, - GET_CHROM_SIZES.out.sizes - ) - // ch_software_versions = ch_software_versions.mix(UCSC_BEDGRAPHTOBIGWIG.out.versions.first().ifEmpty(null)) - ch_versions = ch_versions.mix(UCSC_BEDGRAPHTOBIGWIG.out.versions) + // // + // // SUBWORKFLOW: Fix getting name sorted BAM here for PE/SE + // // + // BAM_CLEAN ( + // MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), + // MAKE_GENOME_FILTER.out.bed.collect(), + // ch_bamtools_filter_se_config, + // ch_bamtools_filter_pe_config + // ) + // // ch_software_versions = ch_software_versions.mix(BAM_CLEAN.out.bamtools_versions.first().ifEmpty(null)) + // ch_versions = ch_versions.mix(BAM_CLEAN.out.versions) + + // // + // // MODULE: Post alignment QC + // // + // PICARD_COLLECTMULTIPLEMETRICS ( + // BAM_CLEAN.out.bam, + // ch_fasta + // ) - // - // MODULE: Coverage plots - // - DEEPTOOLS_COMPUTEMATRIX ( - UCSC_BEDGRAPHTOBIGWIG.out.bigwig, - ch_gene_bed - ) - // ch_software_versions = ch_software_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first().ifEmpty(null)) - ch_versions = ch_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions) + // // TODO Add versions to picard collectmultiplemetrics - DEEPTOOLS_PLOTPROFILE ( - DEEPTOOLS_COMPUTEMATRIX.out.matrix - ) + // // + // // MODULE: Library coverage + // // + // PRESEQ_LCEXTRAP ( + // BAM_CLEAN.out.bam + // ) + // // ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.versions.first().ifEmpty(null)) + // ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions) + + // // + // // MODULE: Strand cross-correlation + // // + // PHANTOMPEAKQUALTOOLS ( + // BAM_CLEAN.out.bam + // ) + // // ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions.first().ifEmpty(null)) + // ch_versions = ch_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions) + + // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( + // PHANTOMPEAKQUALTOOLS.out.spp.join(PHANTOMPEAKQUALTOOLS.out.rdata, by: [0]), + // ch_spp_nsc_header, + // ch_spp_rsc_header, + // ch_spp_correlation_header + // ) - DEEPTOOLS_PLOTHEATMAP ( - DEEPTOOLS_COMPUTEMATRIX.out.matrix - ) + // // + // // MODULE: Coverage tracks + // // + // BEDTOOLS_GENOMECOV ( + // BAM_CLEAN.out.bam.join(BAM_CLEAN.out.flagstat, by: [0]) + // ) - // - // Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] - // - BAM_CLEAN - .out - .bam - .join ( BAM_CLEAN.out.bai, by: [0] ) - .map { meta, bam, bai -> meta.control ? null : [ meta.id, [ bam ] , [ bai ] ] } - .set { ch_control_bam_bai } - - BAM_CLEAN - .out - .bam - .join ( BAM_CLEAN.out.bai, by: [0] ) - .map { meta, bam, bai -> meta.control ? [ meta.control, meta, [ bam ], [ bai ] ] : null } - .combine(ch_control_bam_bai, by: 0) - .map { it -> [ it[1] , it[2] + it[4], it[3] + it[5] ] } - .set { ch_ip_control_bam_bai } + // // + // // MODULE: Coverage tracks + // // + // UCSC_BEDGRAPHTOBIGWIG ( + // BEDTOOLS_GENOMECOV.out.bedgraph, + // GET_CHROM_SIZES.out.sizes + // ) + // // ch_software_versions = ch_software_versions.mix(UCSC_BEDGRAPHTOBIGWIG.out.versions.first().ifEmpty(null)) + // ch_versions = ch_versions.mix(UCSC_BEDGRAPHTOBIGWIG.out.versions) + + // // + // // MODULE: Coverage plots + // // + // DEEPTOOLS_COMPUTEMATRIX ( + // UCSC_BEDGRAPHTOBIGWIG.out.bigwig, + // ch_gene_bed + // ) + // // ch_software_versions = ch_software_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first().ifEmpty(null)) + // ch_versions = ch_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions) - // - // plotFingerprint for IP and control together - // - DEEPTOOLS_PLOTFINGERPRINT ( - ch_ip_control_bam_bai - ) + // DEEPTOOLS_PLOTPROFILE ( + // DEEPTOOLS_COMPUTEMATRIX.out.matrix + // ) - if (params.macs_gsize) { - - // - // Call peaks - // - - // Create channel: [ val(meta), ip_bam, control_bam ] - ch_ip_control_bam_bai - .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } - .set { ch_ip_control_bam } - - MACS2_CALLPEAK ( - ch_ip_control_bam, - params.macs_gsize - ) - // ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.versions.first().ifEmpty(null)) - ch_versions = ch_versions.mix(MACS2_CALLPEAK.out.versions) - - ch_ip_control_bam - .join(MACS2_CALLPEAK.out.peak, by: [0]) - .map { it -> [ it[0], it[1], it[3] ] } - .set { ch_ip_peak } - FRIP_SCORE ( - ch_ip_peak - ) - - ch_ip_peak - .join(FRIP_SCORE.out.txt, by: [0]) - .map { it -> [ it[0], it[2], it[3] ] } - .set { ch_ip_peak_frip } - MULTIQC_CUSTOM_PEAKS ( - ch_ip_peak_frip, - ch_peak_count_header, - ch_frip_score_header - ) - - PLOT_MACS2_QC ( - MACS2_CALLPEAK.out.peak.collect{it[1]} - ) - - HOMER_ANNOTATEPEAKS_MACS2 ( - MACS2_CALLPEAK.out.peak, - ch_fasta, - ch_gtf - ) - // ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first().ifEmpty(null)) - ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions) - - PLOT_HOMER_ANNOTATEPEAKS ( - HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, - ch_peak_annotation_header, - "_peaks.annotatePeaks.txt" - ) - - // Create channel: [ meta , [ peaks ] ] - // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] - MACS2_CALLPEAK - .out - .peak - .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } - .groupTuple() - .map { - antibody, groups, peaks -> - [ - antibody, - groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, - peaks - ] } - .map { - antibody, groups, peaks -> - def meta = [:] - meta.id = antibody - meta.multiple_groups = groups.size() > 1 - meta.replicates_exist = groups.max { groups.value }.value > 1 - [ meta, peaks ] } - .set { ch_antibody_peaks } - - MACS2_CONSENSUS ( - ch_antibody_peaks - ) - - HOMER_ANNOTATEPEAKS_CONSENSUS ( - MACS2_CONSENSUS.out.bed, - ch_fasta, - ch_gtf - ) - // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt - // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt - - // Create channel: [ val(meta), ip_bam ] - MACS2_CONSENSUS - .out - .saf - .map { meta, saf -> [ meta.id, meta, saf ] } - .set { ch_ip_saf } - - ch_ip_control_bam - .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } - .combine(ch_ip_saf) - .map { - it -> - fmeta = it[1] - fmeta['replicates_exist'] = it[4]['replicates_exist'] - fmeta['multiple_groups'] = it[4]['multiple_groups'] - [ fmeta, it[2], it[5] ] } - .set { ch_ip_bam } - - SUBREAD_FEATURECOUNTS ( - ch_ip_bam - ) - // ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first().ifEmpty(null)) - ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions) - - // - // DESEQ2_FEATURECOUNTS ( - // params.modules['deseq2_featurecounts'] - // ) - // ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) - // ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) + // DEEPTOOLS_PLOTHEATMAP ( + // DEEPTOOLS_COMPUTEMATRIX.out.matrix + // ) - } + // // + // // Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] + // // + // BAM_CLEAN + // .out + // .bam + // .join ( BAM_CLEAN.out.bai, by: [0] ) + // .map { meta, bam, bai -> meta.control ? null : [ meta.id, [ bam ] , [ bai ] ] } + // .set { ch_control_bam_bai } + + // BAM_CLEAN + // .out + // .bam + // .join ( BAM_CLEAN.out.bai, by: [0] ) + // .map { meta, bam, bai -> meta.control ? [ meta.control, meta, [ bam ], [ bai ] ] : null } + // .combine(ch_control_bam_bai, by: 0) + // .map { it -> [ it[1] , it[2] + it[4], it[3] + it[5] ] } + // .set { ch_ip_control_bam_bai } + + // // + // // plotFingerprint for IP and control together + // // + // DEEPTOOLS_PLOTFINGERPRINT ( + // ch_ip_control_bam_bai + // ) - // - // Create IGV session - // - IGV ( - ch_fasta, - UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), - MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), - MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), - params.modules['ucsc_bedgraphtobigwig'], - params.modules['macs2_callpeak'], - params.modules['macs2_consensus'] - ) + // if (params.macs_gsize) { + + // // + // // Call peaks + // // + + // // Create channel: [ val(meta), ip_bam, control_bam ] + // ch_ip_control_bam_bai + // .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } + // .set { ch_ip_control_bam } + + // MACS2_CALLPEAK ( + // ch_ip_control_bam, + // params.macs_gsize + // ) + // // ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.versions.first().ifEmpty(null)) + // ch_versions = ch_versions.mix(MACS2_CALLPEAK.out.versions) + + // ch_ip_control_bam + // .join(MACS2_CALLPEAK.out.peak, by: [0]) + // .map { it -> [ it[0], it[1], it[3] ] } + // .set { ch_ip_peak } + // FRIP_SCORE ( + // ch_ip_peak + // ) + + // ch_ip_peak + // .join(FRIP_SCORE.out.txt, by: [0]) + // .map { it -> [ it[0], it[2], it[3] ] } + // .set { ch_ip_peak_frip } + // MULTIQC_CUSTOM_PEAKS ( + // ch_ip_peak_frip, + // ch_peak_count_header, + // ch_frip_score_header + // ) + + // PLOT_MACS2_QC ( + // MACS2_CALLPEAK.out.peak.collect{it[1]} + // ) + + // HOMER_ANNOTATEPEAKS_MACS2 ( + // MACS2_CALLPEAK.out.peak, + // ch_fasta, + // ch_gtf + // ) + // // ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first().ifEmpty(null)) + // ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions) + + // PLOT_HOMER_ANNOTATEPEAKS ( + // HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, + // ch_peak_annotation_header, + // "_peaks.annotatePeaks.txt" + // ) + + // // Create channel: [ meta , [ peaks ] ] + // // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] + // MACS2_CALLPEAK + // .out + // .peak + // .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } + // .groupTuple() + // .map { + // antibody, groups, peaks -> + // [ + // antibody, + // groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, + // peaks + // ] } + // .map { + // antibody, groups, peaks -> + // def meta = [:] + // meta.id = antibody + // meta.multiple_groups = groups.size() > 1 + // meta.replicates_exist = groups.max { groups.value }.value > 1 + // [ meta, peaks ] } + // .set { ch_antibody_peaks } + + // MACS2_CONSENSUS ( + // ch_antibody_peaks + // ) + + // HOMER_ANNOTATEPEAKS_CONSENSUS ( + // MACS2_CONSENSUS.out.bed, + // ch_fasta, + // ch_gtf + // ) + // // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt + // // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt + + // // Create channel: [ val(meta), ip_bam ] + // MACS2_CONSENSUS + // .out + // .saf + // .map { meta, saf -> [ meta.id, meta, saf ] } + // .set { ch_ip_saf } + + // ch_ip_control_bam + // .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } + // .combine(ch_ip_saf) + // .map { + // it -> + // fmeta = it[1] + // fmeta['replicates_exist'] = it[4]['replicates_exist'] + // fmeta['multiple_groups'] = it[4]['multiple_groups'] + // [ fmeta, it[2], it[5] ] } + // .set { ch_ip_bam } + + // SUBREAD_FEATURECOUNTS ( + // ch_ip_bam + // ) + // // ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first().ifEmpty(null)) + // ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions) + + // // + // // DESEQ2_FEATURECOUNTS ( + // // params.modules['deseq2_featurecounts'] + // // ) + // // ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) + // // ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) + + // } + + // // + // // Create IGV session + // // + // IGV ( + // ch_fasta, + // UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), + // MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), + // MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), + // params.modules['ucsc_bedgraphtobigwig'], + // params.modules['macs2_callpeak'], + // params.modules['macs2_consensus'] + // ) - // - // MODULE: Pipeline reporting - // - // ch_software_versions - // .map { it -> if (it) [ it.baseName, it ] } - // .groupTuple() - // .map { it[1][0] } - // .flatten() - // .collect() - // .set { ch_software_versions } - - // GET_SOFTWARE_VERSIONS ( - // ch_software_versions.map { it }.collect() //, - // // params.modules['get_software_versions'] // TODO check if its needed, I think that addParams does the trick + // // + // // MODULE: Pipeline reporting + // // + // // ch_software_versions + // // .map { it -> if (it) [ it.baseName, it ] } + // // .groupTuple() + // // .map { it[1][0] } + // // .flatten() + // // .collect() + // // .set { ch_software_versions } + + // // GET_SOFTWARE_VERSIONS ( + // // ch_software_versions.map { it }.collect() //, + // // // params.modules['get_software_versions'] // TODO check if its needed, I think that addParams does the trick + // // ) + // CUSTOM_DUMPSOFTWAREVERSIONS ( + // ch_versions.unique().collectFile() // ) - CUSTOM_DUMPSOFTWAREVERSIONS ( - ch_versions.unique().collectFile() - ) - OUTPUT_DOCUMENTATION ( - ch_output_docs, - ch_output_docs_images - ) + // OUTPUT_DOCUMENTATION ( + // ch_output_docs, + // ch_output_docs_images + // ) - // - // MODULE: MultiQC - // - // ch_multiqc_files = Channel.empty() - // ch_multiqc_files = ch_multiqc_files.mix(Channel.from(ch_multiqc_config)) - // ch_multiqc_files = ch_multiqc_files.mix(ch_multiqc_custom_config.collect().ifEmpty([])) - // ch_multiqc_files = ch_multiqc_files.mix(ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml')) - // ch_multiqc_files = ch_multiqc_files.mix(GET_SOFTWARE_VERSIONS.out.yaml.collect()) - // ch_multiqc_files = ch_multiqc_files.mix(FASTQC.out.zip.collect{it[1]}.ifEmpty([])) - - if (!params.skip_multiqc) { - workflow_summary = WorkflowChipseq.paramsSummaryMultiqc(workflow, summary_params) - ch_workflow_summary = Channel.value(workflow_summary) - - MULTIQC ( - ch_multiqc_config, - ch_multiqc_custom_config.collect().ifEmpty([]), - CUSTOM_DUMPSOFTWAREVERSIONS.out.mqc_yml.collect(), - ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml'), - - FASTQC_TRIMGALORE.out.fastqc_zip.collect{it[1]}.ifEmpty([]), - FASTQC_TRIMGALORE.out.trim_log.collect{it[1]}.ifEmpty([]), - FASTQC_TRIMGALORE.out.trim_zip.collect{it[1]}.ifEmpty([]), - - MAP_BWA_MEM.out.stats.collect{it[1]}, - MAP_BWA_MEM.out.flagstat.collect{it[1]}, - MAP_BWA_MEM.out.idxstats.collect{it[1]}, - - MARK_DUPLICATES_PICARD.out.stats.collect{it[1]}.ifEmpty([]), - MARK_DUPLICATES_PICARD.out.flagstat.collect{it[1]}.ifEmpty([]), - MARK_DUPLICATES_PICARD.out.idxstats.collect{it[1]}.ifEmpty([]), - MARK_DUPLICATES_PICARD.out.metrics.collect{it[1]}.ifEmpty([]), - - BAM_CLEAN.out.stats.collect{it[1]}.ifEmpty([]), - BAM_CLEAN.out.flagstat.collect{it[1]}.ifEmpty([]), - BAM_CLEAN.out.idxstats.collect{it[1]}.ifEmpty([]), - PICARD_COLLECTMULTIPLEMETRICS.out.metrics.collect{it[1]}.ifEmpty([]), - - PRESEQ_LCEXTRAP.out.ccurve.collect{it[1]}.ifEmpty([]), - DEEPTOOLS_PLOTPROFILE.out.table.collect{it[1]}.ifEmpty([]), - DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect{it[1]}.ifEmpty([]), - PHANTOMPEAKQUALTOOLS.out.spp.collect{it[1]}.ifEmpty([]), - MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.nsc.collect{it[1]}.ifEmpty([]), - MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.rsc.collect{it[1]}.ifEmpty([]), - MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.correlation.collect{it[1]}.ifEmpty([]), - - MULTIQC_CUSTOM_PEAKS.out.count.collect{it[1]}.ifEmpty([]), - MULTIQC_CUSTOM_PEAKS.out.frip.collect{it[1]}.ifEmpty([]), - PLOT_HOMER_ANNOTATEPEAKS.out.tsv.collect().ifEmpty([]), - SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), - // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) - ) - multiqc_report = MULTIQC.out.report.toList() - } + // // + // // MODULE: MultiQC + // // + // // ch_multiqc_files = Channel.empty() + // // ch_multiqc_files = ch_multiqc_files.mix(Channel.from(ch_multiqc_config)) + // // ch_multiqc_files = ch_multiqc_files.mix(ch_multiqc_custom_config.collect().ifEmpty([])) + // // ch_multiqc_files = ch_multiqc_files.mix(ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml')) + // // ch_multiqc_files = ch_multiqc_files.mix(GET_SOFTWARE_VERSIONS.out.yaml.collect()) + // // ch_multiqc_files = ch_multiqc_files.mix(FASTQC.out.zip.collect{it[1]}.ifEmpty([])) + + // if (!params.skip_multiqc) { + // workflow_summary = WorkflowChipseq.paramsSummaryMultiqc(workflow, summary_params) + // ch_workflow_summary = Channel.value(workflow_summary) + + // MULTIQC ( + // ch_multiqc_config, + // ch_multiqc_custom_config.collect().ifEmpty([]), + // CUSTOM_DUMPSOFTWAREVERSIONS.out.mqc_yml.collect(), + // ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml'), + + // FASTQC_TRIMGALORE.out.fastqc_zip.collect{it[1]}.ifEmpty([]), + // FASTQC_TRIMGALORE.out.trim_log.collect{it[1]}.ifEmpty([]), + // FASTQC_TRIMGALORE.out.trim_zip.collect{it[1]}.ifEmpty([]), + + // MAP_BWA_MEM.out.stats.collect{it[1]}, + // MAP_BWA_MEM.out.flagstat.collect{it[1]}, + // MAP_BWA_MEM.out.idxstats.collect{it[1]}, + + // MARK_DUPLICATES_PICARD.out.stats.collect{it[1]}.ifEmpty([]), + // MARK_DUPLICATES_PICARD.out.flagstat.collect{it[1]}.ifEmpty([]), + // MARK_DUPLICATES_PICARD.out.idxstats.collect{it[1]}.ifEmpty([]), + // MARK_DUPLICATES_PICARD.out.metrics.collect{it[1]}.ifEmpty([]), + + // BAM_CLEAN.out.stats.collect{it[1]}.ifEmpty([]), + // BAM_CLEAN.out.flagstat.collect{it[1]}.ifEmpty([]), + // BAM_CLEAN.out.idxstats.collect{it[1]}.ifEmpty([]), + // PICARD_COLLECTMULTIPLEMETRICS.out.metrics.collect{it[1]}.ifEmpty([]), + + // PRESEQ_LCEXTRAP.out.ccurve.collect{it[1]}.ifEmpty([]), + // DEEPTOOLS_PLOTPROFILE.out.table.collect{it[1]}.ifEmpty([]), + // DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect{it[1]}.ifEmpty([]), + // PHANTOMPEAKQUALTOOLS.out.spp.collect{it[1]}.ifEmpty([]), + // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.nsc.collect{it[1]}.ifEmpty([]), + // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.rsc.collect{it[1]}.ifEmpty([]), + // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.correlation.collect{it[1]}.ifEmpty([]), + + // MULTIQC_CUSTOM_PEAKS.out.count.collect{it[1]}.ifEmpty([]), + // MULTIQC_CUSTOM_PEAKS.out.frip.collect{it[1]}.ifEmpty([]), + // PLOT_HOMER_ANNOTATEPEAKS.out.tsv.collect().ifEmpty([]), + // SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), + // // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) + // ) + // multiqc_report = MULTIQC.out.report.toList() + // } } /* From 5463b5a661cd75708c20a19915d88ea43ac48687 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Sun, 24 Oct 2021 10:47:24 +0100 Subject: [PATCH 209/538] Make linters happy --- README.md | 2 +- docs/usage.md | 1 - nextflow_schema.json | 23 +++++++++++++++++++---- 3 files changed, 20 insertions(+), 6 deletions(-) diff --git a/README.md b/README.md index 5ab753299..5af5d8b22 100644 --- a/README.md +++ b/README.md @@ -18,7 +18,7 @@ **nfcore/chipseq** is a bioinformatics analysis pipeline used for Chromatin ImmunopreciPitation sequencing (ChIP-seq) data. -On release, automated continuous integration tests run the pipeline on a [full-sized dataset](https://github.com/nf-core/test-datasets/tree/chipseq#full-test-dataset-origin) obtained from the SRA on the AWS cloud infrastructure. This ensures that the pipeline runs on AWS, has sensible resource allocation defaults set to run on real-world datasets, and permits the persistent storage of results to benchmark between pipeline releases and other analysis sources. The results obtained from running the full-sized tests can be viewed on the [nf-core website](https://nf-co.re/chipseq/results). +On release, automated continuous integration tests run the pipeline on a [full-sized dataset](https://github.com/nf-core/test-datasets/tree/chipseq#full-test-dataset-origin) on the AWS cloud infrastructure. The dataset consists of FoxA1 (transcription factor) and EZH2 (histone,mark) IP experiments from _Franco et al. 2015_ ([GEO: GSE59530](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE59530), [PMID: 25752574](https://pubmed.ncbi.nlm.nih.gov/25752574/)) and _Popovic et al. 2014_ ([GEO: GSE57632](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE57632), [PMID: 25188243](https://pubmed.ncbi.nlm.nih.gov/25188243/)), respectively. This ensures that the pipeline runs on AWS, has sensible resource allocation defaults set to run on real-world datasets, and permits the persistent storage of results to benchmark between pipeline releases and other analysis sources. The results obtained from running the full-sized tests can be viewed on the [nf-core website](https://nf-co.re/chipseq/results). The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool to run tasks across multiple compute infrastructures in a very portable manner. It uses Docker/Singularity containers making installation trivial and results highly reproducible. The [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) implementation of this pipeline uses one container per process which makes it much easier to maintain and update software dependencies. Where possible, these processes have been submitted to and installed from [nf-core/modules](https://github.com/nf-core/modules) in order to make them available to all nf-core pipelines, and to everyone within the Nextflow community! diff --git a/docs/usage.md b/docs/usage.md index be0b64545..29975a438 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -4,7 +4,6 @@ > _Documentation of pipeline parameters is generated automatically from the pipeline schema and can no longer be found in markdown files._ - ## Samplesheet input You will need to create a samplesheet with information about the samples you would like to analyse before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 5 columns, and a header row as shown in the examples below. diff --git a/nextflow_schema.json b/nextflow_schema.json index 7067f0d60..ad9c90f75 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -73,15 +73,27 @@ "mimetype": "text/plain", "pattern": "^\\S+\\.fn?a(sta)?(\\.gz)?$", "description": "Path to FASTA genome file.", - "help_text": "This parameter is *mandatory* if `--genome` is not specified. If you don't have a BWA index available this will be generated for you automatically. Combine with `--save_reference` to save BWA index for future runs.", + "help_text": "This parameter is *mandatory* if `--genome` is not specified. If you don't have the appropriate alignment index available this will be generated for you automatically. Combine with `--save_reference` to save alignment index for future runs.", "fa_icon": "far fa-file-code" }, "gtf": { "type": "string", + "format": "file-path", + "mimetype": "text/plain", + "pattern": "^\\S+\\.gtf(\\.gz)?$", "description": "Path to GTF annotation file.", - "fa_icon": "fas fa-file-invoice", + "fa_icon": "fas fa-code-branch", "help_text": "This parameter is *mandatory* if `--genome` is not specified." }, + "gff": { + "type": "string", + "format": "file-path", + "mimetype": "text/plain", + "pattern": "^\\S+\\.gff(\\.gz)?$", + "fa_icon": "fas fa-code-branch", + "description": "Path to GFF3 annotation file.", + "help_text": "This parameter must be specified if `--genome` or `--gtf` are not specified." + }, "bwa_index": { "type": "string", "description": "Full path to directory containing BWA index including base name. i.e. `/path/to/index/genome.fa`.", @@ -89,8 +101,11 @@ }, "gene_bed": { "type": "string", - "description": "Path to BED file containing gene intervals. This will be created from the GTF file if not specified.", - "fa_icon": "fas fa-procedures" + "format": "file-path", + "mimetype": "text/plain", + "pattern": "^\\S+\\.bed(\\.gz)?$", + "fa_icon": "fas fa-procedures", + "description": "Path to BED file containing gene intervals. This will be created from the GTF file if not specified." }, "macs_gsize": { "type": "number", From 14120742649607dfb7635615fd22b7d6dd8db0c1 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Sun, 24 Oct 2021 11:01:39 +0100 Subject: [PATCH 210/538] Fix tyop --- README.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/README.md b/README.md index 5af5d8b22..0a637910a 100644 --- a/README.md +++ b/README.md @@ -74,7 +74,7 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool ```bash nextflow run nf-core/chipseq \ - --input samplsheet.csv \ + --input samplesheet.csv \ --genome GRCh37 \ -profile ``` From 12aeea76cf64d5096d975948f7b40470cf17be45 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Sun, 24 Oct 2021 13:59:51 +0100 Subject: [PATCH 211/538] Update nf-core modules --- modules/nf-core/modules/bwa/index/meta.yml | 1 + modules/nf-core/modules/bwa/mem/meta.yml | 1 + .../custom/dumpsoftwareversions/meta.yml | 2 +- modules/nf-core/modules/fastqc/meta.yml | 1 + modules/nf-core/modules/gffread/functions.nf | 78 +++++++++++++++++++ modules/nf-core/modules/gffread/main.nf | 40 ++++++++++ modules/nf-core/modules/gffread/meta.yml | 33 ++++++++ modules/nf-core/modules/gunzip/functions.nf | 78 +++++++++++++++++++ modules/nf-core/modules/gunzip/main.nf | 41 ++++++++++ modules/nf-core/modules/gunzip/meta.yml | 28 +++++++ .../modules/homer/annotatepeaks/meta.yml | 1 + modules/nf-core/modules/multiqc/meta.yml | 1 + .../picard/collectmultiplemetrics/meta.yml | 1 + .../modules/picard/markduplicates/meta.yml | 1 + .../modules/picard/mergesamfiles/meta.yml | 1 + .../modules/samtools/flagstat/meta.yml | 1 + .../modules/samtools/idxstats/meta.yml | 1 + .../nf-core/modules/samtools/index/meta.yml | 1 + .../nf-core/modules/samtools/sort/meta.yml | 1 + .../nf-core/modules/samtools/stats/meta.yml | 1 + modules/nf-core/modules/trimgalore/meta.yml | 1 + modules/nf-core/modules/untar/functions.nf | 78 +++++++++++++++++++ modules/nf-core/modules/untar/main.nf | 41 ++++++++++ modules/nf-core/modules/untar/meta.yml | 28 +++++++ 24 files changed, 460 insertions(+), 1 deletion(-) create mode 100644 modules/nf-core/modules/gffread/functions.nf create mode 100644 modules/nf-core/modules/gffread/main.nf create mode 100644 modules/nf-core/modules/gffread/meta.yml create mode 100644 modules/nf-core/modules/gunzip/functions.nf create mode 100644 modules/nf-core/modules/gunzip/main.nf create mode 100644 modules/nf-core/modules/gunzip/meta.yml create mode 100644 modules/nf-core/modules/untar/functions.nf create mode 100644 modules/nf-core/modules/untar/main.nf create mode 100644 modules/nf-core/modules/untar/meta.yml diff --git a/modules/nf-core/modules/bwa/index/meta.yml b/modules/nf-core/modules/bwa/index/meta.yml index c3c0a8d8a..11d62df37 100644 --- a/modules/nf-core/modules/bwa/index/meta.yml +++ b/modules/nf-core/modules/bwa/index/meta.yml @@ -13,6 +13,7 @@ tools: homepage: http://bio-bwa.sourceforge.net/ documentation: http://www.htslib.org/doc/samtools.html arxiv: arXiv:1303.3997 + licence: ['GPL-3.0-or-later'] input: - fasta: type: file diff --git a/modules/nf-core/modules/bwa/mem/meta.yml b/modules/nf-core/modules/bwa/mem/meta.yml index 662385073..61eaddef6 100644 --- a/modules/nf-core/modules/bwa/mem/meta.yml +++ b/modules/nf-core/modules/bwa/mem/meta.yml @@ -16,6 +16,7 @@ tools: homepage: http://bio-bwa.sourceforge.net/ documentation: http://www.htslib.org/doc/samtools.html arxiv: arXiv:1303.3997 + licence: ['GPL-3.0-or-later'] input: - meta: type: map diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml b/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml index 8d4a6ed42..c8310e356 100644 --- a/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml @@ -8,7 +8,7 @@ tools: description: Custom module used to dump software versions within the nf-core pipeline template homepage: https://github.com/nf-core/tools documentation: https://github.com/nf-core/tools - + licence: ['MIT'] input: - versions: type: file diff --git a/modules/nf-core/modules/fastqc/meta.yml b/modules/nf-core/modules/fastqc/meta.yml index 0ae08aee5..b09553a3c 100644 --- a/modules/nf-core/modules/fastqc/meta.yml +++ b/modules/nf-core/modules/fastqc/meta.yml @@ -15,6 +15,7 @@ tools: overrepresented sequences. homepage: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/ documentation: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/ + licence: ['GPL-2.0-only'] input: - meta: type: map diff --git a/modules/nf-core/modules/gffread/functions.nf b/modules/nf-core/modules/gffread/functions.nf new file mode 100644 index 000000000..85628ee0e --- /dev/null +++ b/modules/nf-core/modules/gffread/functions.nf @@ -0,0 +1,78 @@ +// +// Utility functions used in nf-core DSL2 module files +// + +// +// Extract name of software tool from process name using $task.process +// +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +// +// Extract name of module from process name using $task.process +// +def getProcessName(task_process) { + return task_process.tokenize(':')[-1] +} + +// +// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules +// +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.args3 = args.args3 ?: '' + options.publish_by_meta = args.publish_by_meta ?: [] + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files + options.suffix = args.suffix ?: '' + return options +} + +// +// Tidy up and join elements of a list to return a path string +// +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +// +// Function to save/publish module results +// +def saveFiles(Map args) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + + // Do not publish versions.yml unless running from pytest workflow + if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { + return null + } + if (ioptions.publish_by_meta) { + def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta + for (key in key_list) { + if (args.meta && key instanceof String) { + def path = key + if (args.meta.containsKey(key)) { + path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] + } + path = path instanceof String ? path : '' + path_list.add(path) + } + } + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else if (ioptions.publish_files == null) { + return "${getPathFromList(path_list)}/$args.filename" + } +} diff --git a/modules/nf-core/modules/gffread/main.nf b/modules/nf-core/modules/gffread/main.nf new file mode 100644 index 000000000..4133ee087 --- /dev/null +++ b/modules/nf-core/modules/gffread/main.nf @@ -0,0 +1,40 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' + +params.options = [:] +options = initOptions(params.options) + +process GFFREAD { + tag "$gff" + label 'process_low' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:[:], publish_by_meta:[]) } + + conda (params.enable_conda ? "bioconda::gffread=0.12.1" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://depot.galaxyproject.org/singularity/gffread:0.12.1--h8b12597_0" + } else { + container "quay.io/biocontainers/gffread:0.12.1--h8b12597_0" + } + + input: + path gff + + output: + path "*.gtf" , emit: gtf + path "versions.yml" , emit: versions + + script: + def prefix = options.suffix ? "${gff.baseName}${options.suffix}" : "${gff.baseName}" + """ + gffread \\ + $gff \\ + $options.args \\ + -o ${prefix}.gtf + cat <<-END_VERSIONS > versions.yml + ${getProcessName(task.process)}: + ${getSoftwareName(task.process)}: \$(gffread --version 2>&1) + END_VERSIONS + """ +} diff --git a/modules/nf-core/modules/gffread/meta.yml b/modules/nf-core/modules/gffread/meta.yml new file mode 100644 index 000000000..bf1a15cba --- /dev/null +++ b/modules/nf-core/modules/gffread/meta.yml @@ -0,0 +1,33 @@ +name: gffread +description: Validate, filter, convert and perform various other operations on GFF files +keywords: + - gff + - conversion + - validation +tools: + - gffread: + description: GFF/GTF utility providing format conversions, region filtering, FASTA sequence extraction and more. + homepage: http://ccb.jhu.edu/software/stringtie/gff.shtml#gffread + documentation: http://ccb.jhu.edu/software/stringtie/gff.shtml#gffread + tool_dev_url: https://github.com/gpertea/gffread + doi: 10.12688/f1000research.23297.1 + licence: ['MIT'] + +input: + - gff: + type: file + description: A reference file in either the GFF3, GFF2 or GTF format. + pattern: "*.{gff, gtf}" + +output: + - gtf: + type: file + description: GTF file resulting from the conversion of the GFF input file + pattern: "*.{gtf}" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" + +authors: + - "@emiller88" diff --git a/modules/nf-core/modules/gunzip/functions.nf b/modules/nf-core/modules/gunzip/functions.nf new file mode 100644 index 000000000..85628ee0e --- /dev/null +++ b/modules/nf-core/modules/gunzip/functions.nf @@ -0,0 +1,78 @@ +// +// Utility functions used in nf-core DSL2 module files +// + +// +// Extract name of software tool from process name using $task.process +// +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +// +// Extract name of module from process name using $task.process +// +def getProcessName(task_process) { + return task_process.tokenize(':')[-1] +} + +// +// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules +// +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.args3 = args.args3 ?: '' + options.publish_by_meta = args.publish_by_meta ?: [] + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files + options.suffix = args.suffix ?: '' + return options +} + +// +// Tidy up and join elements of a list to return a path string +// +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +// +// Function to save/publish module results +// +def saveFiles(Map args) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + + // Do not publish versions.yml unless running from pytest workflow + if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { + return null + } + if (ioptions.publish_by_meta) { + def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta + for (key in key_list) { + if (args.meta && key instanceof String) { + def path = key + if (args.meta.containsKey(key)) { + path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] + } + path = path instanceof String ? path : '' + path_list.add(path) + } + } + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else if (ioptions.publish_files == null) { + return "${getPathFromList(path_list)}/$args.filename" + } +} diff --git a/modules/nf-core/modules/gunzip/main.nf b/modules/nf-core/modules/gunzip/main.nf new file mode 100644 index 000000000..aec4569fa --- /dev/null +++ b/modules/nf-core/modules/gunzip/main.nf @@ -0,0 +1,41 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' + +params.options = [:] +options = initOptions(params.options) + +process GUNZIP { + tag "$archive" + label 'process_low' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:[:], publish_by_meta:[]) } + + conda (params.enable_conda ? "conda-forge::sed=4.7" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://containers.biocontainers.pro/s3/SingImgsRepo/biocontainers/v1.2.0_cv1/biocontainers_v1.2.0_cv1.img" + } else { + container "biocontainers/biocontainers:v1.2.0_cv1" + } + + input: + path archive + + output: + path "$gunzip", emit: gunzip + path "versions.yml" , emit: versions + + script: + gunzip = archive.toString() - '.gz' + """ + gunzip \\ + -f \\ + $options.args \\ + $archive + + cat <<-END_VERSIONS > versions.yml + ${getProcessName(task.process)}: + ${getSoftwareName(task.process)}: \$(echo \$(gunzip --version 2>&1) | sed 's/^.*(gzip) //; s/ Copyright.*\$//') + END_VERSIONS + """ +} diff --git a/modules/nf-core/modules/gunzip/meta.yml b/modules/nf-core/modules/gunzip/meta.yml new file mode 100644 index 000000000..3482f0d28 --- /dev/null +++ b/modules/nf-core/modules/gunzip/meta.yml @@ -0,0 +1,28 @@ +name: gunzip +description: Compresses and decompresses files. +keywords: + - gunzip + - compression +tools: + - gunzip: + description: | + gzip is a file format and a software application used for file compression and decompression. + documentation: https://www.gnu.org/software/gzip/manual/gzip.html + licence: ['GPL-3.0-or-later'] +input: + - archive: + type: file + description: File to be compressed/uncompressed + pattern: "*.*" +output: + - gunzip: + type: file + description: Compressed/uncompressed file + pattern: "*.*" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" +authors: + - "@joseespinosa" + - "@drpatelh" diff --git a/modules/nf-core/modules/homer/annotatepeaks/meta.yml b/modules/nf-core/modules/homer/annotatepeaks/meta.yml index 39fe4197e..c3ab9460e 100644 --- a/modules/nf-core/modules/homer/annotatepeaks/meta.yml +++ b/modules/nf-core/modules/homer/annotatepeaks/meta.yml @@ -10,6 +10,7 @@ tools: HOMER (Hypergeometric Optimization of Motif EnRichment) is a suite of tools for Motif Discovery and next-gen sequencing analysis. documentation: http://homer.ucsd.edu/homer/ doi: 10.1016/j.molcel.2010.05.004. + licence: ['GPL-3.0-or-later'] input: - meta: type: map diff --git a/modules/nf-core/modules/multiqc/meta.yml b/modules/nf-core/modules/multiqc/meta.yml index a54f95aca..63c75a450 100644 --- a/modules/nf-core/modules/multiqc/meta.yml +++ b/modules/nf-core/modules/multiqc/meta.yml @@ -11,6 +11,7 @@ tools: It's a general use tool, perfect for summarising the output from numerous bioinformatics tools. homepage: https://multiqc.info/ documentation: https://multiqc.info/docs/ + licence: ['GPL-3.0-or-later'] input: - multiqc_files: type: file diff --git a/modules/nf-core/modules/picard/collectmultiplemetrics/meta.yml b/modules/nf-core/modules/picard/collectmultiplemetrics/meta.yml index 587983a19..613afc622 100644 --- a/modules/nf-core/modules/picard/collectmultiplemetrics/meta.yml +++ b/modules/nf-core/modules/picard/collectmultiplemetrics/meta.yml @@ -14,6 +14,7 @@ tools: data and formats such as SAM/BAM/CRAM and VCF. homepage: https://broadinstitute.github.io/picard/ documentation: https://broadinstitute.github.io/picard/ + licence: ['MIT'] input: - meta: type: map diff --git a/modules/nf-core/modules/picard/markduplicates/meta.yml b/modules/nf-core/modules/picard/markduplicates/meta.yml index 13f2d3502..c9a08b36f 100644 --- a/modules/nf-core/modules/picard/markduplicates/meta.yml +++ b/modules/nf-core/modules/picard/markduplicates/meta.yml @@ -14,6 +14,7 @@ tools: data and formats such as SAM/BAM/CRAM and VCF. homepage: https://broadinstitute.github.io/picard/ documentation: https://broadinstitute.github.io/picard/ + licence: ['MIT'] input: - meta: type: map diff --git a/modules/nf-core/modules/picard/mergesamfiles/meta.yml b/modules/nf-core/modules/picard/mergesamfiles/meta.yml index f732daf4c..3d010c3ce 100644 --- a/modules/nf-core/modules/picard/mergesamfiles/meta.yml +++ b/modules/nf-core/modules/picard/mergesamfiles/meta.yml @@ -12,6 +12,7 @@ tools: data and formats such as SAM/BAM/CRAM and VCF. homepage: https://broadinstitute.github.io/picard/ documentation: https://broadinstitute.github.io/picard/ + licence: ['MIT'] input: - meta: type: map diff --git a/modules/nf-core/modules/samtools/flagstat/meta.yml b/modules/nf-core/modules/samtools/flagstat/meta.yml index d408cb764..9bd9ff891 100644 --- a/modules/nf-core/modules/samtools/flagstat/meta.yml +++ b/modules/nf-core/modules/samtools/flagstat/meta.yml @@ -16,6 +16,7 @@ tools: homepage: http://www.htslib.org/ documentation: hhttp://www.htslib.org/doc/samtools.html doi: 10.1093/bioinformatics/btp352 + licence: ['MIT'] input: - meta: type: map diff --git a/modules/nf-core/modules/samtools/idxstats/meta.yml b/modules/nf-core/modules/samtools/idxstats/meta.yml index f4cb613f2..ec542f34b 100644 --- a/modules/nf-core/modules/samtools/idxstats/meta.yml +++ b/modules/nf-core/modules/samtools/idxstats/meta.yml @@ -17,6 +17,7 @@ tools: homepage: http://www.htslib.org/ documentation: hhttp://www.htslib.org/doc/samtools.html doi: 10.1093/bioinformatics/btp352 + licence: ['MIT'] input: - meta: type: map diff --git a/modules/nf-core/modules/samtools/index/meta.yml b/modules/nf-core/modules/samtools/index/meta.yml index 5f4dd3fbc..988e8f53b 100644 --- a/modules/nf-core/modules/samtools/index/meta.yml +++ b/modules/nf-core/modules/samtools/index/meta.yml @@ -14,6 +14,7 @@ tools: homepage: http://www.htslib.org/ documentation: hhttp://www.htslib.org/doc/samtools.html doi: 10.1093/bioinformatics/btp352 + licence: ['MIT'] input: - meta: type: map diff --git a/modules/nf-core/modules/samtools/sort/meta.yml b/modules/nf-core/modules/samtools/sort/meta.yml index cd47c86d1..3402a0680 100644 --- a/modules/nf-core/modules/samtools/sort/meta.yml +++ b/modules/nf-core/modules/samtools/sort/meta.yml @@ -14,6 +14,7 @@ tools: homepage: http://www.htslib.org/ documentation: hhttp://www.htslib.org/doc/samtools.html doi: 10.1093/bioinformatics/btp352 + licence: ['MIT'] input: - meta: type: map diff --git a/modules/nf-core/modules/samtools/stats/meta.yml b/modules/nf-core/modules/samtools/stats/meta.yml index d75d73e25..ae41498a2 100644 --- a/modules/nf-core/modules/samtools/stats/meta.yml +++ b/modules/nf-core/modules/samtools/stats/meta.yml @@ -15,6 +15,7 @@ tools: homepage: http://www.htslib.org/ documentation: hhttp://www.htslib.org/doc/samtools.html doi: 10.1093/bioinformatics/btp352 + licence: ['MIT'] input: - meta: type: map diff --git a/modules/nf-core/modules/trimgalore/meta.yml b/modules/nf-core/modules/trimgalore/meta.yml index 7c46bea92..c7e1df1de 100644 --- a/modules/nf-core/modules/trimgalore/meta.yml +++ b/modules/nf-core/modules/trimgalore/meta.yml @@ -13,6 +13,7 @@ tools: MspI-digested RRBS-type (Reduced Representation Bisufite-Seq) libraries. homepage: https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/ documentation: https://github.com/FelixKrueger/TrimGalore/blob/master/Docs/Trim_Galore_User_Guide.md + licence: ['GPL-3.0-or-later'] input: - meta: type: map diff --git a/modules/nf-core/modules/untar/functions.nf b/modules/nf-core/modules/untar/functions.nf new file mode 100644 index 000000000..85628ee0e --- /dev/null +++ b/modules/nf-core/modules/untar/functions.nf @@ -0,0 +1,78 @@ +// +// Utility functions used in nf-core DSL2 module files +// + +// +// Extract name of software tool from process name using $task.process +// +def getSoftwareName(task_process) { + return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() +} + +// +// Extract name of module from process name using $task.process +// +def getProcessName(task_process) { + return task_process.tokenize(':')[-1] +} + +// +// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules +// +def initOptions(Map args) { + def Map options = [:] + options.args = args.args ?: '' + options.args2 = args.args2 ?: '' + options.args3 = args.args3 ?: '' + options.publish_by_meta = args.publish_by_meta ?: [] + options.publish_dir = args.publish_dir ?: '' + options.publish_files = args.publish_files + options.suffix = args.suffix ?: '' + return options +} + +// +// Tidy up and join elements of a list to return a path string +// +def getPathFromList(path_list) { + def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries + paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes + return paths.join('/') +} + +// +// Function to save/publish module results +// +def saveFiles(Map args) { + def ioptions = initOptions(args.options) + def path_list = [ ioptions.publish_dir ?: args.publish_dir ] + + // Do not publish versions.yml unless running from pytest workflow + if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { + return null + } + if (ioptions.publish_by_meta) { + def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta + for (key in key_list) { + if (args.meta && key instanceof String) { + def path = key + if (args.meta.containsKey(key)) { + path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] + } + path = path instanceof String ? path : '' + path_list.add(path) + } + } + } + if (ioptions.publish_files instanceof Map) { + for (ext in ioptions.publish_files) { + if (args.filename.endsWith(ext.key)) { + def ext_list = path_list.collect() + ext_list.add(ext.value) + return "${getPathFromList(ext_list)}/$args.filename" + } + } + } else if (ioptions.publish_files == null) { + return "${getPathFromList(path_list)}/$args.filename" + } +} diff --git a/modules/nf-core/modules/untar/main.nf b/modules/nf-core/modules/untar/main.nf new file mode 100644 index 000000000..efb9d8251 --- /dev/null +++ b/modules/nf-core/modules/untar/main.nf @@ -0,0 +1,41 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' + +params.options = [:] +options = initOptions(params.options) + +process UNTAR { + tag "$archive" + label 'process_low' + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:[:], publish_by_meta:[]) } + + conda (params.enable_conda ? "conda-forge::sed=4.7" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://containers.biocontainers.pro/s3/SingImgsRepo/biocontainers/v1.2.0_cv1/biocontainers_v1.2.0_cv1.img" + } else { + container "biocontainers/biocontainers:v1.2.0_cv1" + } + + input: + path archive + + output: + path "$untar" , emit: untar + path "versions.yml", emit: versions + + script: + untar = archive.toString() - '.tar.gz' + """ + tar \\ + -xzvf \\ + $options.args \\ + $archive + + cat <<-END_VERSIONS > versions.yml + ${getProcessName(task.process)}: + ${getSoftwareName(task.process)}: \$(echo \$(tar --version 2>&1) | sed 's/^.*(GNU tar) //; s/ Copyright.*\$//') + END_VERSIONS + """ +} diff --git a/modules/nf-core/modules/untar/meta.yml b/modules/nf-core/modules/untar/meta.yml new file mode 100644 index 000000000..51f94995e --- /dev/null +++ b/modules/nf-core/modules/untar/meta.yml @@ -0,0 +1,28 @@ +name: untar +description: Extract files. +keywords: + - untar + - uncompress +tools: + - untar: + description: | + Extract tar.gz files. + documentation: https://www.gnu.org/software/tar/manual/ + licence: ['GPL-3.0-or-later'] +input: + - archive: + type: file + description: File to be untar + pattern: "*.{tar}.{gz}" +output: + - untar: + type: file + description: + pattern: "*.*" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" +authors: + - "@joseespinosa" + - "@drpatelh" From e93520f5f551c24f2b95b1e5c5ed7caa4b00841c Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Sun, 24 Oct 2021 14:00:08 +0100 Subject: [PATCH 212/538] Update local modules --- modules/local/genome_blacklist_regions.nf | 51 +++++++++++++++++++++++ modules/local/get_chrom_sizes.nf | 15 ++++--- modules/local/gtf2bed.nf | 6 +-- 3 files changed, 60 insertions(+), 12 deletions(-) create mode 100644 modules/local/genome_blacklist_regions.nf diff --git a/modules/local/genome_blacklist_regions.nf b/modules/local/genome_blacklist_regions.nf new file mode 100644 index 000000000..e28a749b9 --- /dev/null +++ b/modules/local/genome_blacklist_regions.nf @@ -0,0 +1,51 @@ +// Import generic module functions +include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' + +params.options = [:] + +/* + * Prepare genome intervals for filtering by removing regions in blacklist file + */ +process GENOME_BLACKLIST_REGIONS { + tag "$sizes" + publishDir "${params.outdir}", + mode: params.publish_dir_mode, + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'genome', meta:[:], publish_by_meta:[]) } + + conda (params.enable_conda ? "bioconda::bedtools=2.30.0" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://depot.galaxyproject.org/singularity/bedtools:2.30.0--hc088bd4_0" + } else { + container "quay.io/biocontainers/bedtools:2.30.0--hc088bd4_0" + } + + input: + path sizes + path blacklist + + output: + path '*.bed' , emit: bed + path "versions.yml", emit: versions + + script: + def file_out = "${sizes.simpleName}.include_regions.bed" + if (blacklist) { + """ + sortBed -i $blacklist -g $sizes | complementBed -i stdin -g $sizes > $file_out + + cat <<-END_VERSIONS > versions.yml + ${getProcessName(task.process)}: + bedtools: \$(bedtools --version | sed -e "s/bedtools v//g") + END_VERSIONS + """ + } else { + """ + awk '{print \$1, '0' , \$2}' OFS='\t' $sizes > $file_out + + cat <<-END_VERSIONS > versions.yml + ${getProcessName(task.process)}: + bedtools: \$(bedtools --version | sed -e "s/bedtools v//g") + END_VERSIONS + """ + } +} diff --git a/modules/local/get_chrom_sizes.nf b/modules/local/get_chrom_sizes.nf index 4f23f478a..b9fa2ac92 100644 --- a/modules/local/get_chrom_sizes.nf +++ b/modules/local/get_chrom_sizes.nf @@ -3,20 +3,17 @@ include { saveFiles; getProcessName } from './functions' params.options = [:] -/* - * Get chromosome sizes from a fasta file - */ process GET_CHROM_SIZES { tag "$fasta" publishDir "${params.outdir}", mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'genome', meta:[:], publish_by_meta:[]) } - conda (params.enable_conda ? 'bioconda::samtools=1.13' : null) + conda (params.enable_conda ? "bioconda::samtools=1.10" : null) if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/samtools:1.13--h8c37831_0" + container "https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" } else { - container "quay.io/biocontainers/samtools:1.13--h8c37831_0" + container "quay.io/biocontainers/samtools:1.10--h9402c20_2" } input: @@ -28,9 +25,11 @@ process GET_CHROM_SIZES { path "versions.yml", emit: versions script: - def software = 'samtools' """ - samtools faidx $fasta + samtools \\ + faidx \\ + $fasta + cut -f 1,2 ${fasta}.fai > ${fasta}.sizes cat <<-END_VERSIONS > versions.yml diff --git a/modules/local/gtf2bed.nf b/modules/local/gtf2bed.nf index 903ac65b9..ea2519c81 100644 --- a/modules/local/gtf2bed.nf +++ b/modules/local/gtf2bed.nf @@ -3,9 +3,6 @@ include { saveFiles; getProcessName } from './functions' params.options = [:] -/* - * Convert GTF file to BED format - */ process GTF2BED { tag "$gtf" label 'process_low' @@ -24,7 +21,8 @@ process GTF2BED { path gtf output: - path '*.bed' + path '*.bed' , emit: bed + path "versions.yml", emit: versions script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ """ From de8c21750d9b78309f2ebab2205bf1ae5691565d Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Sun, 24 Oct 2021 14:01:47 +0100 Subject: [PATCH 213/538] Add prepare_genome subworkflow and get running until trimming --- conf/modules.config | 158 +++++------ modules.json | 37 ++- modules/local/make_genome_filter.nf | 52 ---- modules/local/output_documentation.nf | 27 -- .../{bam_clean.nf => filter_bam_bamtools.nf} | 2 +- subworkflows/local/prepare_genome.nf | 141 ++++++++++ .../{map_bwa_mem.nf => align_bwa_mem.nf} | 2 +- subworkflows/nf-core/fastqc_trimgalore.nf | 56 ++-- workflows/chipseq.nf | 245 ++++++++---------- 9 files changed, 377 insertions(+), 343 deletions(-) delete mode 100644 modules/local/make_genome_filter.nf delete mode 100644 modules/local/output_documentation.nf rename subworkflows/local/{bam_clean.nf => filter_bam_bamtools.nf} (98%) create mode 100644 subworkflows/local/prepare_genome.nf rename subworkflows/nf-core/{map_bwa_mem.nf => align_bwa_mem.nf} (98%) diff --git a/conf/modules.config b/conf/modules.config index ae0f6c356..24c18c3a3 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -22,143 +22,147 @@ params { modules { + 'gffread' { + args = '--keep-exon-attrs -F -T' + publish_dir = 'genome' + } + 'bwa_index' { + args = "-a bwtsw" + publish_dir = "genome/index" + } 'fastqc' { - args = "--quiet" + args = "--quiet" } 'trimgalore' { - args = "--fastqc" - } - 'bwa_index' { - args = "-a bwtsw" - publish_dir = "genome/bwa_index" + args = "--fastqc" } 'bwa_mem' { - args = "-M" - args2 = "-h -F 0x0100 -O BAM" - publish_dir = "bwa/library" - suffix = ".Lb" + args = "-M" + args2 = "-h -F 0x0100 -O BAM" + publish_dir = "bwa/library" + suffix = ".Lb" } 'samtools_sort_lib' { - publish_dir = "bwa/library" - suffix = ".Lb.sorted" + publish_dir = "bwa/library" + suffix = ".Lb.sorted" } 'picard_mergesamfiles' { - args = "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.sorted" + args = "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.sorted" } 'picard_markduplicates' { - args = "--ASSUME_SORTED true --REMOVE_DUPLICATES false --VALIDATION_STRINGENCY LENIENT --TMP_DIR tmp" - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.mkD.sorted" + args = "--ASSUME_SORTED true --REMOVE_DUPLICATES false --VALIDATION_STRINGENCY LENIENT --TMP_DIR tmp" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.mkD.sorted" } 'samtools_sort_merged_lib' { - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.mkD.sorted" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.mkD.sorted" } 'bam_filter' { - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.flT.sorted" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.flT.sorted" } 'bam_remove_orphans' { - args = "--only_fr_pairs" - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.clN" + args = "--only_fr_pairs" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.clN" } 'samtools_sort_filter' { - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.clN.sorted" + publish_dir = "bwa/mergedLibrary" + suffix = ".mLb.clN.sorted" } 'picard_collectmultiplemetrics' { - args = "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" - publish_dir = "bwa/mergedLibrary/picard_metrics" - suffix = ".mLb.clN.sorted" + args = "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" + publish_dir = "bwa/mergedLibrary/picard_metrics" + suffix = ".mLb.clN.sorted" } 'preseq_lcextrap' { - args = "-verbose -bam -seed 1" - publish_dir = "bwa/mergedLibrary/preseq" - suffix = ".mLb.clN" + args = "-verbose -bam -seed 1" + publish_dir = "bwa/mergedLibrary/preseq" + suffix = ".mLb.clN" } 'phantompeakqualtools' { - publish_dir = "bwa/mergedLibrary/phantompeakqualtools" - suffix = ".mLb.clN" + publish_dir = "bwa/mergedLibrary/phantompeakqualtools" + suffix = ".mLb.clN" } 'multiqc_custom_phantompeakqualtools' { - publish_dir = "multiqc" - publish_files = [:] + publish_dir = "multiqc" + publish_files = [:] } 'bedtools_genomecov' { - publish_dir = "bwa/mergedLibrary/bigwig" - suffix = ".mLb.clN" + publish_dir = "bwa/mergedLibrary/bigwig" + suffix = ".mLb.clN" } 'ucsc_bedgraphtobigwig' { - publish_dir = "bwa/mergedLibrary/bigwig" - suffix = ".mLb.clN" + publish_dir = "bwa/mergedLibrary/bigwig" + suffix = ".mLb.clN" } 'deeptools_computematrix' { - args = "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels" - publish_dir = "bwa/mergedLibrary/deeptools" - suffix = ".mLb.clN" + args = "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels" + publish_dir = "bwa/mergedLibrary/deeptools" + suffix = ".mLb.clN" } 'deeptools_plotprofile' { - publish_dir = "bwa/mergedLibrary/deeptools" - suffix = ".mLb.clN" + publish_dir = "bwa/mergedLibrary/deeptools" + suffix = ".mLb.clN" } 'deeptools_plotheatmap' { - publish_dir = "bwa/mergedLibrary/deeptools" - suffix = ".mLb.clN" + publish_dir = "bwa/mergedLibrary/deeptools" + suffix = ".mLb.clN" } 'deeptools_plotfingerprint' { - args = "--skipZeros" - publish_dir = "bwa/mergedLibrary/deeptools" - suffix = ".mLb.clN" + args = "--skipZeros" + publish_dir = "bwa/mergedLibrary/deeptools" + suffix = ".mLb.clN" } 'macs2_callpeak' { - args = "--keep-dup all" - publish_dir = "bwa/mergedLibrary/macs2" + args = "--keep-dup all" + publish_dir = "bwa/mergedLibrary/macs2" } 'frip_score' { - args = "-bed -c -f 0.20" - publish_dir = "frip" - publish_files = [:] + args = "-bed -c -f 0.20" + publish_dir = "frip" + publish_files = [:] } 'multiqc_custom_peaks' { - publish_dir = "multiqc" - publish_files = [:] + publish_dir = "multiqc" + publish_files = [:] } 'plot_macs2_qc' { - args = "-o ./ -p macs2_peak" - publish_dir = "bwa/mergedLibrary/macs2" + args = "-o ./ -p macs2_peak" + publish_dir = "bwa/mergedLibrary/macs2" } 'homer_annotatepeaks_macs2' { - args = "-gid" - publish_dir = "bwa/mergedLibrary/macs2" - suffix = "_peaks" + args = "-gid" + publish_dir = "bwa/mergedLibrary/macs2" + suffix = "_peaks" } 'plot_homer_annotatepeaks' { - args = "-o ./ -p macs2_annotatePeaks" - publish_dir = "bwa/mergedLibrary/macs2" + args = "-o ./ -p macs2_annotatePeaks" + publish_dir = "bwa/mergedLibrary/macs2" } 'macs2_consensus' { - publish_dir = "bwa/mergedLibrary/macs2" - publish_by_id = true + publish_dir = "bwa/mergedLibrary/macs2" + publish_by_id = true } 'homer_annotatepeaks_consensus' { - args = "-gid" - publish_dir = "bwa/mergedLibrary/macs2" - publish_by_id = true - suffix = ".consensus_peaks" + args = "-gid" + publish_dir = "bwa/mergedLibrary/macs2" + publish_by_id = true + suffix = ".consensus_peaks" } 'subread_featurecounts' { - args = "-F SAF -O --fracOverlap 0.2" - publish_dir = "bwa/mergedLibrary/macs2" + args = "-F SAF -O --fracOverlap 0.2" + publish_dir = "bwa/mergedLibrary/macs2" + } + 'deseq2_featurecounts' { + publish_dir = "bwa/mergedLibrary/macs2" } - //'deseq2_featurecounts' { - // publish_dir = "bwa/mergedLibrary/macs2" - //} 'multiqc' { args = '' - publish_dir = "multiqc" + publish_dir = "multiqc" } } } diff --git a/modules.json b/modules.json index 832103e19..1d5fdedc8 100644 --- a/modules.json +++ b/modules.json @@ -4,13 +4,13 @@ "repos": { "nf-core/modules": { "bwa/index": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" }, "bwa/mem": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" }, "custom/dumpsoftwareversions": { - "git_sha": "84f2302920078b0cf7716b2a2e5fcc0be5c4531d" + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" }, "deeptools/computematrix": { "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" @@ -25,55 +25,64 @@ "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" }, "fastqc": { + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + }, + "gffread": { "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" }, + "gunzip": { + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + }, "homer/annotatepeaks": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" }, "macs2/callpeak": { "git_sha": "7b3315591a149609e27914965f858c9a7e071564" }, "multiqc": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" }, "phantompeakqualtools": { "git_sha": "7b3315591a149609e27914965f858c9a7e071564" }, "picard/collectmultiplemetrics": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" }, "picard/markduplicates": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" }, "picard/mergesamfiles": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" }, "preseq/lcextrap": { "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" }, "samtools/flagstat": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" }, "samtools/idxstats": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" }, "samtools/index": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" }, "samtools/sort": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" }, "samtools/stats": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" }, "subread/featurecounts": { "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" }, "trimgalore": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" }, "ucsc/bedgraphtobigwig": { "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + }, + "untar": { + "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" } } } diff --git a/modules/local/make_genome_filter.nf b/modules/local/make_genome_filter.nf deleted file mode 100644 index 1b85b3db2..000000000 --- a/modules/local/make_genome_filter.nf +++ /dev/null @@ -1,52 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] - -/* - * Prepare genome intervals for filtering by removing regions in blacklist file - */ -process MAKE_GENOME_FILTER { - tag "$sizes" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'genome', meta:[:], publish_by_meta:[]) } - - conda (params.enable_conda ? "bioconda::bedtools=2.30.0" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/bedtools:2.30.0--hc088bd4_0" - } else { - container "quay.io/biocontainers/bedtools:2.30.0--hc088bd4_0" - } - - input: - path sizes - path blacklist - - output: - path '*.bed' , emit: bed - path "versions.yml", emit: versions - - script: - def software = 'bedtools' - def file_out = "${sizes.simpleName}.include_regions.bed" - if (params.blacklist) { - """ - sortBed -i $blacklist -g $sizes | complementBed -i stdin -g $sizes > $file_out - - cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - bedtools: \$(bedtools --version | sed -e "s/bedtools v//g") - END_VERSIONS - """ - } else { - """ - awk '{print \$1, '0' , \$2}' OFS='\t' $sizes > $file_out - - cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - bedtools: \$(bedtools --version | sed -e "s/bedtools v//g") - END_VERSIONS - """ - } -} diff --git a/modules/local/output_documentation.nf b/modules/local/output_documentation.nf deleted file mode 100644 index 7a90e8b47..000000000 --- a/modules/local/output_documentation.nf +++ /dev/null @@ -1,27 +0,0 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -params.options = [:] - -/* - * Output Markdown documentation to HTML - */ -process OUTPUT_DOCUMENTATION { - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'pipeline_info', meta:[:], publish_by_meta:[]) } - - conda (params.enable_conda ? "${baseDir}/environment.yml" : null) // TODO update with pointers to singularity and docker container needs markdown library - - input: - path output_docs - path images - - output: - path "results_description.html" - - script: - """ - markdown_to_html.py $output_docs -o results_description.html - """ -} diff --git a/subworkflows/local/bam_clean.nf b/subworkflows/local/filter_bam_bamtools.nf similarity index 98% rename from subworkflows/local/bam_clean.nf rename to subworkflows/local/filter_bam_bamtools.nf index d53912588..63da2f8f8 100644 --- a/subworkflows/local/bam_clean.nf +++ b/subworkflows/local/filter_bam_bamtools.nf @@ -11,7 +11,7 @@ include { BAM_FILTER } from '../../modules/local/bam_filter' add include { BAM_REMOVE_ORPHANS } from '../../modules/local/bam_remove_orphans' addParams( options: params.bam_remove_orphans_options ) include { BAM_SORT_SAMTOOLS } from '../nf-core/bam_sort_samtools' addParams( sort_options: params.samtools_sort_options, index_options: params.samtools_index_options, stats_options: params.samtools_stats_options ) -workflow BAM_CLEAN { +workflow FILTER_BAM_BAMTOOLS { take: ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] ch_bed // channel: [ bed ] diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf new file mode 100644 index 000000000..a8241dab2 --- /dev/null +++ b/subworkflows/local/prepare_genome.nf @@ -0,0 +1,141 @@ +// +// Uncompress and prepare reference genome files +// + +params.genome_options = [:] +params.index_options = [:] +params.gffread_options = [:] +params.bwa_index_options = [:] + +include { + GUNZIP as GUNZIP_FASTA + GUNZIP as GUNZIP_GTF + GUNZIP as GUNZIP_GFF + GUNZIP as GUNZIP_GENE_BED + GUNZIP as GUNZIP_BLACKLIST } from '../../modules/nf-core/modules/gunzip/main' addParams( options: params.genome_options ) +include { UNTAR } from '../../modules/nf-core/modules/untar/main' addParams( options: params.index_options ) +include { GFFREAD } from '../../modules/nf-core/modules/gffread/main' addParams( options: params.gffread_options ) +include { BWA_INDEX } from '../../modules/nf-core/modules/bwa/index/main' addParams( options: params.bwa_index_options ) + +include { GTF2BED } from '../../modules/local/gtf2bed' addParams( options: params.genome_options ) +include { GET_CHROM_SIZES } from '../../modules/local/get_chrom_sizes' addParams( options: params.genome_options ) +include { GENOME_BLACKLIST_REGIONS } from '../../modules/local/genome_blacklist_regions' addParams( options: params.genome_options ) + +workflow PREPARE_GENOME { + + main: + + ch_versions = Channel.empty() + + // + // Uncompress genome fasta file if required + // + if (params.fasta.endsWith('.gz')) { + ch_fasta = GUNZIP_FASTA ( params.fasta ).gunzip + ch_versions = ch_versions.mix(GUNZIP_FASTA.out.versions) + } else { + ch_fasta = file(params.fasta) + } + + // + // Uncompress GTF annotation file or create from GFF3 if required + // + if (params.gtf) { + if (params.gtf.endsWith('.gz')) { + ch_gtf = GUNZIP_GTF ( params.gtf ).gunzip + ch_versions = ch_versions.mix(GUNZIP_GTF.out.versions) + } else { + ch_gtf = file(params.gtf) + } + } else if (params.gff) { + if (params.gff.endsWith('.gz')) { + ch_gff = GUNZIP_GFF ( params.gff ).gunzip + ch_versions = ch_versions.mix(GUNZIP_GFF.out.versions) + } else { + ch_gff = file(params.gff) + } + ch_gtf = GFFREAD ( ch_gff ).gtf + ch_versions = ch_versions.mix(GFFREAD.out.versions) + } + + // + // Uncompress blacklist file if required + // + ch_blacklist = Channel.empty() + if (params.blacklist) { + if (params.blacklist.endsWith('.gz')) { + ch_blacklist = GUNZIP_BLACKLIST ( params.blacklist ).gunzip + ch_versions = ch_versions.mix(GUNZIP_BLACKLIST.out.versions) + } else { + ch_blacklist = file(params.blacklist) + } + } + + // + // Uncompress gene BED annotation file or create from GTF if required + // + + // If --gtf is supplied along with --genome + // Make gene bed from supplied --gtf instead of using iGenomes one automatically + def make_bed = false + if (!params.gene_bed) { + make_bed = true + } else if (params.genome && params.gtf) { + if (params.genomes[ params.genome ].gtf != params.gtf) { + make_bed = true + } + } + + if (make_bed) { + ch_gene_bed = GTF2BED ( ch_gtf ).bed + ch_versions = ch_versions.mix(GTF2BED.out.versions) + } else { + if (params.gene_bed.endsWith('.gz')) { + ch_gene_bed = GUNZIP_GENE_BED ( params.gene_bed ).gunzip + ch_versions = ch_versions.mix(GUNZIP_GENE_BED.out.versions) + } else { + ch_gene_bed = file(params.gene_bed) + } + } + + // + // Create chromosome sizes file + // + ch_chrom_sizes = GET_CHROM_SIZES ( ch_fasta ).sizes + ch_versions = ch_versions.mix(GET_CHROM_SIZES.out.versions) + + // + // Prepare genome intervals for filtering by removing regions in blacklist file + // + GENOME_BLACKLIST_REGIONS ( + GET_CHROM_SIZES.out.sizes, + ch_blacklist.ifEmpty([]) + ) + ch_versions = ch_versions.mix(GENOME_BLACKLIST_REGIONS.out.versions) + + // + // Uncompress BWA index or generate from scratch if required + // + ch_bwa_index = Channel.empty() + if (params.bwa_index) { + if (params.bwa_index.endsWith('.tar.gz')) { + ch_bwa_index = UNTAR ( params.bwa_index ).untar + ch_versions = ch_versions.mix(UNTAR.out.versions) + } else { + ch_bwa_index = file(params.bwa_index) + } + } else { + ch_bwa_index = BWA_INDEX ( ch_fasta ).index + ch_versions = ch_versions.mix(BWA_INDEX.out.versions) + } + + emit: + fasta = ch_fasta // path: genome.fasta + gtf = ch_gtf // path: genome.gtf + gene_bed = ch_gene_bed // path: gene.bed + chrom_sizes = ch_chrom_sizes // path: genome.sizes + blacklist = ch_blacklist // path: blaclist.bed + bwa_index = ch_bwa_index // path: bbsplit/index/ + + versions = ch_versions.ifEmpty(null) // channel: [ versions.yml ] +} diff --git a/subworkflows/nf-core/map_bwa_mem.nf b/subworkflows/nf-core/align_bwa_mem.nf similarity index 98% rename from subworkflows/nf-core/map_bwa_mem.nf rename to subworkflows/nf-core/align_bwa_mem.nf index 8ce4cf9c1..44a9942cb 100644 --- a/subworkflows/nf-core/map_bwa_mem.nf +++ b/subworkflows/nf-core/align_bwa_mem.nf @@ -10,7 +10,7 @@ params.samtools_stats_options = [:] include { BWA_MEM } from '../../modules/nf-core/modules/bwa/mem/main' addParams( options: params.bwa_mem_options ) include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' addParams( sort_options: params.samtools_sort_options, index_options: params.samtools_index_options, stats_options: params.samtools_stats_options ) -workflow MAP_BWA_MEM { +workflow ALIGN_BWA_MEM { take: ch_reads // channel: [ val(meta), [ reads ] ] ch_index // path: /path/to/index diff --git a/subworkflows/nf-core/fastqc_trimgalore.nf b/subworkflows/nf-core/fastqc_trimgalore.nf index f0638abcb..acaab9fd5 100644 --- a/subworkflows/nf-core/fastqc_trimgalore.nf +++ b/subworkflows/nf-core/fastqc_trimgalore.nf @@ -1,51 +1,51 @@ -/* - * Read QC and trimming - */ - +// +// Read QC and trimming +// params.fastqc_options = [:] params.trimgalore_options = [:] -include { FASTQC } from '../../modules/nf-core/modules/fastqc/main' addParams( options: params.fastqc_options ) +include { FASTQC } from '../../modules/nf-core/modules/fastqc/main' addParams( options: params.fastqc_options ) include { TRIMGALORE } from '../../modules/nf-core/modules/trimgalore/main' addParams( options: params.trimgalore_options ) workflow FASTQC_TRIMGALORE { take: - ch_reads // channel: [ val(meta), [ reads ] ] - skip_fastqc // boolean: true/false - skip_trimming // boolean: true/false + reads // channel: [ val(meta), [ reads ] ] + skip_fastqc // boolean: true/false + skip_trimming // boolean: true/false main: - ch_versions = Channel.empty() - fastqc_html = Channel.empty() - fastqc_zip = Channel.empty() + ch_versions = Channel.empty() + fastqc_html = Channel.empty() + fastqc_zip = Channel.empty() if (!skip_fastqc) { - FASTQC(ch_reads).html.set { fastqc_html } - fastqc_zip = FASTQC.out.zip + FASTQC ( reads ).html.set { fastqc_html } + fastqc_zip = FASTQC.out.zip ch_versions = ch_versions.mix(FASTQC.out.versions.first()) } - ch_trim_reads = ch_reads - trim_html = Channel.empty() - trim_zip = Channel.empty() - trim_log = Channel.empty() + trim_reads = reads + trim_html = Channel.empty() + trim_zip = Channel.empty() + trim_log = Channel.empty() if (!skip_trimming) { - TRIMGALORE(ch_reads).reads.set { ch_trim_reads } - trim_html = TRIMGALORE.out.html - trim_zip = TRIMGALORE.out.zip - trim_log = TRIMGALORE.out.log + TRIMGALORE ( reads ).reads.set { trim_reads } + trim_html = TRIMGALORE.out.html + trim_zip = TRIMGALORE.out.zip + trim_log = TRIMGALORE.out.log ch_versions = ch_versions.mix(TRIMGALORE.out.versions.first()) } emit: - fastqc_html // channel: [ val(meta), [ html ] ] - fastqc_zip // channel: [ val(meta), [ zip ] ] + reads = trim_reads // channel: [ val(meta), [ reads ] ] + + fastqc_html // channel: [ val(meta), [ html ] ] + fastqc_zip // channel: [ val(meta), [ zip ] ] - reads = ch_trim_reads // channel: [ val(meta), [ reads ] ] - trim_html // channel: [ val(meta), [ html ] ] - trim_zip // channel: [ val(meta), [ zip ] ] - trim_log // channel: [ val(meta), [ txt ] ] + trim_html // channel: [ val(meta), [ html ] ] + trim_zip // channel: [ val(meta), [ zip ] ] + trim_log // channel: [ val(meta), [ txt ] ] - versions = ch_versions // path: versions.yml + versions = ch_versions.ifEmpty(null) // channel: [ versions.yml ] } diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 43186bbd6..4e7d4aa09 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -20,9 +20,6 @@ def checkPathParamList = [ ] for (param in checkPathParamList) { if (param) { file(param, checkIfExists: true) } } -// Check blacklist file -ch_blacklist = params.blacklist ? file(params.blacklist) : Channel.empty() - // Save AWS IGenomes file containing annotation version def anno_readme = params.genomes[ params.genome ]?.readme if (anno_readme && file(anno_readme).exists()) { @@ -30,17 +27,6 @@ if (anno_readme && file(anno_readme).exists()) { file(anno_readme).copyTo("${params.outdir}/genome/") } -// If --gtf is supplied along with --genome -// Make gene bed from supplied --gtf instead of using iGenomes one automatically -def makeBED = false -if (!params.gene_bed) { - makeBED = true -} else if (params.genome && params.gtf) { - if (params.genomes[ params.genome ].gtf != params.gtf) { - makeBED = true - } -} - def peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' /* @@ -75,39 +61,51 @@ ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering // Don't overwrite global params.modules, create a copy instead and use that within the main script. def modules = params.modules.clone() -def plot_homer_annotatepeaks_options = modules['plot_homer_annotatepeaks'] -plot_homer_annotatepeaks_options.publish_dir += "/$peakType/qc" - -def plot_macs2_qc_options = modules['plot_macs2_qc'] -plot_macs2_qc_options.publish_dir += "/$peakType/qc" - -def macs2_consensus_options = modules['macs2_consensus'] -macs2_consensus_options.publish_dir += "/$peakType/qc" - -def multiqc_options = modules['multiqc'] -multiqc_options.args += params.multiqc_title ? Utils.joinModuleArgs(["--title \"$params.multiqc_title\""]) : '' -multiqc_options.publish_dir += "/$peakType" - -include { GTF2BED } from '../modules/local/gtf2bed' addParams( options: [:] ) -include { GET_CHROM_SIZES } from '../modules/local/get_chrom_sizes' addParams( options: [:] ) -include { MAKE_GENOME_FILTER } from '../modules/local/make_genome_filter' addParams( options: [:] ) -include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_genomecov' addParams( options: modules['bedtools_genomecov'] ) -include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' addParams( options: plot_homer_annotatepeaks_options ) -include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' addParams( options: plot_macs2_qc_options ) -include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' addParams( options: macs2_consensus_options ) -include { FRIP_SCORE } from '../modules/local/frip_score' addParams( options: modules['frip_score'] ) -//include { DESEQ2_QC } from '../modules/local/deseq2_qc' addParams( options: deseq2_qc_options, multiqc_label: 'star_salmon' ) -include { IGV } from '../modules/local/igv' addParams( options: [:] ) -include { OUTPUT_DOCUMENTATION } from '../modules/local/output_documentation' addParams( options: [:] ) -include { MULTIQC } from '../modules/local/multiqc' addParams( options: multiqc_options ) -include { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS } from '../modules/local/multiqc_custom_phantompeakqualtools' addParams( options: modules['multiqc_custom_phantompeakqualtools'] ) -include { MULTIQC_CUSTOM_PEAKS } from '../modules/local/multiqc_custom_peaks' addParams( options: modules['multiqc_custom_peaks'] ) +// def plot_homer_annotatepeaks_options = modules['plot_homer_annotatepeaks'] +// plot_homer_annotatepeaks_options.publish_dir += "/$peakType/qc" + +// def plot_macs2_qc_options = modules['plot_macs2_qc'] +// plot_macs2_qc_options.publish_dir += "/$peakType/qc" + +// def macs2_consensus_options = modules['macs2_consensus'] +// macs2_consensus_options.publish_dir += "/$peakType/qc" + +// def multiqc_options = modules['multiqc'] +// multiqc_options.args += params.multiqc_title ? Utils.joinModuleArgs(["--title \"$params.multiqc_title\""]) : '' +// multiqc_options.publish_dir += "/$peakType" + +// include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_genomecov' addParams( options: modules['bedtools_genomecov'] ) +// include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' addParams( options: plot_homer_annotatepeaks_options ) +// include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' addParams( options: plot_macs2_qc_options ) +// include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' addParams( options: macs2_consensus_options ) +// include { FRIP_SCORE } from '../modules/local/frip_score' addParams( options: modules['frip_score'] ) +// //include { DESEQ2_QC } from '../modules/local/deseq2_qc' addParams( options: deseq2_qc_options, multiqc_label: 'star_salmon' ) +// include { IGV } from '../modules/local/igv' addParams( options: [:] ) +// include { MULTIQC } from '../modules/local/multiqc' addParams( options: multiqc_options ) // TODO review +// include { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS } from '../modules/local/multiqc_custom_phantompeakqualtools' addParams( options: modules['multiqc_custom_phantompeakqualtools'] ) +// include { MULTIQC_CUSTOM_PEAKS } from '../modules/local/multiqc_custom_peaks' addParams( options: modules['multiqc_custom_peaks'] ) // // SUBWORKFLOW: Consisting of a mix of local and nf-core/modules // -include { INPUT_CHECK } from '../subworkflows/local/input_check' addParams( options: [:] ) -include { BAM_CLEAN } from '../subworkflows/local/bam_clean' addParams( bam_filter_options: modules['bam_filter'], bam_remove_orphans_options: modules['bam_remove_orphans'], samtools_sort_options: modules['samtools_sort_filter'], samtools_index_options: modules['samtools_sort_filter'], samtools_stats_options: modules['samtools_sort_filter'] ) + +def publish_genome_options = params.save_reference ? [publish_dir: 'genome'] : [publish_files: false] +def publish_index_options = params.save_reference ? [publish_dir: 'genome/index'] : [publish_files: false] + +def gffread_options = modules['gffread'] +if (!params.save_reference) { gffread_options['publish_files'] = false } + +def bwa_index_options = modules['bwa_index'] +if (!params.save_reference) { bwa_index_options['publish_files'] = false } + +include { INPUT_CHECK } from '../subworkflows/local/input_check' addParams( options: [:] ) +include { PREPARE_GENOME } from '../subworkflows/local/prepare_genome' addParams( + genome_options : publish_genome_options, + index_options : publish_index_options, + gffread_options : gffread_options, + bwa_index_options : bwa_index_options +) +// include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' addParams( bam_filter_options: modules['bam_filter'], bam_remove_orphans_options: modules['bam_remove_orphans'], samtools_sort_options: modules['samtools_sort_filter'], samtools_index_options: modules['samtools_sort_filter'], samtools_stats_options: modules['samtools_sort_filter'] ) /* ======================================================================================== @@ -118,53 +116,53 @@ include { BAM_CLEAN } from '../subworkflows/local/bam_clean' addParams( bam_ // // MODULE: Installed directly from nf-core/modules // -def deeptools_plotfingerprint_options = modules['deeptools_plotfingerprint'] -deeptools_plotfingerprint_options.args += " --numberOfSamples $params.fingerprint_bins" -def macs2_callpeak_options = modules['macs2_callpeak'] -macs2_callpeak_options.args += params.narrow_peak ? '' : Utils.joinModuleArgs(['--broad', "--broad-cutoff ${params.broad_cutoff}"]) -macs2_callpeak_options.args += params.save_macs_pileup ? Utils.joinModuleArgs(['--bdg', '--SPMR']) : '' -macs2_callpeak_options.args += params.macs_fdr ? Utils.joinModuleArgs(["--qvalue ${params.macs_fdr}"]) : '' -macs2_callpeak_options.args += params.macs_pvalue ? Utils.joinModuleArgs(["--pvalue ${params.macs_pvalue}"]) : '' -macs2_callpeak_options['publish_dir'] += "/$peakType" - -def subread_featurecounts_options = modules['subread_featurecounts'] -subread_featurecounts_options['publish_dir'] += "/$peakType/consensus" - -def homer_annotatepeaks_macs2_options = modules['homer_annotatepeaks_macs2'] -homer_annotatepeaks_macs2_options['publish_dir'] += "/$peakType" - -def homer_annotatepeaks_consensus_options = modules['homer_annotatepeaks_consensus'] -homer_annotatepeaks_consensus_options['publish_dir'] += "/$peakType/consensus" - -// -// MODULE: Installed directly from nf-core/modules -// -include { FASTQC } from '../modules/nf-core/modules/fastqc/main' addParams( options: modules['fastqc'] ) -// include { MULTIQC } from '../modules/nf-core/modules/multiqc/main' addParams( options: multiqc_options ) // TODO review -include { BWA_INDEX } from '../modules/nf-core/modules/bwa/index/main' addParams( options: modules['bwa_index'] ) -include { PICARD_MERGESAMFILES } from '../modules/nf-core/modules/picard/mergesamfiles/main' addParams( options: modules['picard_mergesamfiles'] ) -include { PICARD_COLLECTMULTIPLEMETRICS } from '../modules/nf-core/modules/picard/collectmultiplemetrics/main' addParams( options: modules['picard_collectmultiplemetrics'] ) -include { PRESEQ_LCEXTRAP } from '../modules/nf-core/modules/preseq/lcextrap/main' addParams( options: modules['preseq_lcextrap'] ) -include { UCSC_BEDGRAPHTOBIGWIG } from '../modules/nf-core/modules/ucsc/bedgraphtobigwig/main' addParams( options: modules['ucsc_bedgraphtobigwig'] ) -include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/modules/deeptools/computematrix/main' addParams( options: modules['deeptools_computematrix'] ) -include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/modules/deeptools/plotprofile/main' addParams( options: modules['deeptools_plotprofile'] ) -include { DEEPTOOLS_PLOTHEATMAP } from '../modules/nf-core/modules/deeptools/plotheatmap/main' addParams( options: modules['deeptools_plotheatmap'] ) -include { DEEPTOOLS_PLOTFINGERPRINT } from '../modules/nf-core/modules/deeptools/plotfingerprint/main' addParams( options: deeptools_plotfingerprint_options ) -include { PHANTOMPEAKQUALTOOLS } from '../modules/nf-core/modules/phantompeakqualtools/main' addParams( options: modules['phantompeakqualtools'] ) -include { MACS2_CALLPEAK } from '../modules/nf-core/modules/macs2/callpeak/main' addParams( options: macs2_callpeak_options ) -include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/modules/subread/featurecounts/main' addParams( options: subread_featurecounts_options ) +// def deeptools_plotfingerprint_options = modules['deeptools_plotfingerprint'] +// deeptools_plotfingerprint_options.args += " --numberOfSamples $params.fingerprint_bins" + +// def macs2_callpeak_options = modules['macs2_callpeak'] +// macs2_callpeak_options.args += params.narrow_peak ? '' : Utils.joinModuleArgs(['--broad', "--broad-cutoff ${params.broad_cutoff}"]) +// macs2_callpeak_options.args += params.save_macs_pileup ? Utils.joinModuleArgs(['--bdg', '--SPMR']) : '' +// macs2_callpeak_options.args += params.macs_fdr ? Utils.joinModuleArgs(["--qvalue ${params.macs_fdr}"]) : '' +// macs2_callpeak_options.args += params.macs_pvalue ? Utils.joinModuleArgs(["--pvalue ${params.macs_pvalue}"]) : '' +// macs2_callpeak_options['publish_dir'] += "/$peakType" + +// def subread_featurecounts_options = modules['subread_featurecounts'] +// subread_featurecounts_options['publish_dir'] += "/$peakType/consensus" + +// def homer_annotatepeaks_macs2_options = modules['homer_annotatepeaks_macs2'] +// homer_annotatepeaks_macs2_options['publish_dir'] += "/$peakType" + +// def homer_annotatepeaks_consensus_options = modules['homer_annotatepeaks_consensus'] +// homer_annotatepeaks_consensus_options['publish_dir'] += "/$peakType/consensus" + +// include { PICARD_MERGESAMFILES } from '../modules/nf-core/modules/picard/mergesamfiles/main' addParams( options: modules['picard_mergesamfiles'] ) +// include { PICARD_COLLECTMULTIPLEMETRICS } from '../modules/nf-core/modules/picard/collectmultiplemetrics/main' addParams( options: modules['picard_collectmultiplemetrics'] ) +// include { PRESEQ_LCEXTRAP } from '../modules/nf-core/modules/preseq/lcextrap/main' addParams( options: modules['preseq_lcextrap'] ) +// include { UCSC_BEDGRAPHTOBIGWIG } from '../modules/nf-core/modules/ucsc/bedgraphtobigwig/main' addParams( options: modules['ucsc_bedgraphtobigwig'] ) +// include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/modules/deeptools/computematrix/main' addParams( options: modules['deeptools_computematrix'] ) +// include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/modules/deeptools/plotprofile/main' addParams( options: modules['deeptools_plotprofile'] ) +// include { DEEPTOOLS_PLOTHEATMAP } from '../modules/nf-core/modules/deeptools/plotheatmap/main' addParams( options: modules['deeptools_plotheatmap'] ) +// include { DEEPTOOLS_PLOTFINGERPRINT } from '../modules/nf-core/modules/deeptools/plotfingerprint/main' addParams( options: deeptools_plotfingerprint_options ) +// include { PHANTOMPEAKQUALTOOLS } from '../modules/nf-core/modules/phantompeakqualtools/main' addParams( options: modules['phantompeakqualtools'] ) +// include { MACS2_CALLPEAK } from '../modules/nf-core/modules/macs2/callpeak/main' addParams( options: macs2_callpeak_options ) +// include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/modules/subread/featurecounts/main' addParams( options: subread_featurecounts_options ) include { CUSTOM_DUMPSOFTWAREVERSIONS } from '../modules/nf-core/modules/custom/dumpsoftwareversions/main' addParams( options: [publish_files : ['_versions.yml':'']] ) -include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_macs2_options ) -include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_consensus_options ) +// include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_macs2_options ) +// include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_consensus_options ) // // SUBWORKFLOW: Consisting entirely of nf-core/modules // -include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' addParams( fastqc_options: modules['fastqc'], trimgalore_options: modules['trimgalore'] ) -include { MAP_BWA_MEM } from '../subworkflows/nf-core/map_bwa_mem' addParams( bwa_mem_options: modules['bwa_mem'], samtools_sort_options: modules['samtools_sort_lib'], samtools_index_options: modules['samtools_sort_lib'], samtools_stats_options: modules['samtools_sort_lib'] ) -include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' addParams( markduplicates_options: modules['picard_markduplicates'], samtools_index_options: modules['samtools_sort_merged_lib'] , samtools_stats_options: modules['samtools_sort_merged_lib'] ) + +def trimgalore_options = modules['trimgalore'] +trimgalore_options.args += params.trim_nextseq > 0 ? Utils.joinModuleArgs(["--nextseq ${params.trim_nextseq}"]) : '' +if (params.save_trimmed) { trimgalore_options.publish_files.put('fq.gz','') } + +include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' addParams( fastqc_options: modules['fastqc'], trimgalore_options: trimgalore_options ) +// include { ALIGN_BWA_MEM } from '../subworkflows/nf-core/align_bwa_mem' addParams( bwa_mem_options: modules['bwa_mem'], samtools_sort_options: modules['samtools_sort_lib'], samtools_index_options: modules['samtools_sort_lib'], samtools_stats_options: modules['samtools_sort_lib'] ) +// include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' addParams( markduplicates_options: modules['picard_markduplicates'], samtools_index_options: modules['samtools_sort_merged_lib'] , samtools_stats_options: modules['samtools_sort_merged_lib'] ) /* ======================================================================================== @@ -179,6 +177,12 @@ workflow CHIPSEQ { ch_versions = Channel.empty() + // + // SUBWORKFLOW: Uncompress and prepare reference genome files + // + PREPARE_GENOME () + ch_versions = ch_versions.mix(PREPARE_GENOME.out.versions) + // // SUBWORKFLOW: Read in samplesheet, validate and stage input files // @@ -188,42 +192,15 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(INPUT_CHECK.out.versions) - // // - // // MODULE: Run FastQC - // // - // // TODO check if this fastqc process from nf-core is needed Don't think so done in FASTQC_TRIMGALORE - // // FASTQC ( - // // INPUT_CHECK.out.reads - // // ) - // // ch_software_versions = ch_software_versions.mix(FASTQC.out.versions.first().ifEmpty(null)) - - // // - // // SUBWORKFLOW: Prepare genome files - // // - // ch_index = params.bwa_index ? Channel.value(file(params.bwa_index)) : BWA_INDEX ( ch_fasta ).index - - // if (makeBED) { ch_gene_bed = GTF2BED ( ch_gtf ) } - - // MAKE_GENOME_FILTER ( - // GET_CHROM_SIZES ( ch_fasta ).sizes, - // ch_blacklist.ifEmpty([]) - // ) - // // ch_software_versions = Channel.empty() - // // ch_software_versions = ch_software_versions.mix(MAKE_GENOME_FILTER.out.versions.first().ifEmpty(null)) - // ch_versions = ch_versions.mix(MAKE_GENOME_FILTER.out.versions) - - // // - // // SUBWORKFLOW: Read QC & trimming - // // - // nextseq = params.trim_nextseq > 0 ? " --nextseq ${params.trim_nextseq}" : '' - // params.modules['trimgalore'].args += nextseq - // FASTQC_TRIMGALORE ( - // INPUT_CHECK.out.reads, - // params.skip_fastqc, - // params.skip_trimming - // ) - // // ch_software_versions = ch_software_versions.mix(FASTQC_TRIMGALORE.out.fastqc_versions.first().ifEmpty(null)) - // ch_versions = ch_versions.mix(FASTQC_TRIMGALORE.out.versions) + // + // SUBWORKFLOW: Read QC and trim adapters + // + FASTQC_TRIMGALORE ( + INPUT_CHECK.out.reads, + params.skip_fastqc || params.skip_qc, + params.skip_trimming + ) + ch_versions = ch_versions.mix(FASTQC_TRIMGALORE.out.versions) // // // // SUBWORKFLOW: Map reads & BAM QC @@ -509,30 +486,12 @@ workflow CHIPSEQ { // params.modules['macs2_consensus'] // ) - // // - // // MODULE: Pipeline reporting - // // - // // ch_software_versions - // // .map { it -> if (it) [ it.baseName, it ] } - // // .groupTuple() - // // .map { it[1][0] } - // // .flatten() - // // .collect() - // // .set { ch_software_versions } - - // // GET_SOFTWARE_VERSIONS ( - // // ch_software_versions.map { it }.collect() //, - // // // params.modules['get_software_versions'] // TODO check if its needed, I think that addParams does the trick - // // ) - // CUSTOM_DUMPSOFTWAREVERSIONS ( - // ch_versions.unique().collectFile() - // ) - - - // OUTPUT_DOCUMENTATION ( - // ch_output_docs, - // ch_output_docs_images - // ) + // + // MODULE: Pipeline reporting + // + CUSTOM_DUMPSOFTWAREVERSIONS ( + ch_versions.unique().collectFile(name: 'collated_versions.yml') + ) // // // // MODULE: MultiQC From d78c44b621d72e0fe1e100ef6b60804b033e2953 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 25 Oct 2021 12:33:12 +0200 Subject: [PATCH 214/538] Add default for skip_qc and in json schema --- CHANGELOG.md | 1 + nextflow.config | 1 + nextflow_schema.json | 5 +++++ 3 files changed, 7 insertions(+) diff --git a/CHANGELOG.md b/CHANGELOG.md index c97a823ce..06cee4a48 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -23,6 +23,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 | `--clusterOptions` | | | `--conda` | `--enable_conda` | | `--single_end` | | +| | `--skip_qc` | > **NB:** Parameter has been __updated__ if both old and new parameter information is present. > **NB:** Parameter has been __added__ if just the new parameter information is present. diff --git a/nextflow.config b/nextflow.config index de649c6ee..86f36760b 100644 --- a/nextflow.config +++ b/nextflow.config @@ -49,6 +49,7 @@ params { skip_diff_analysis = false // Options: QC + skip_qc = false skip_fastqc = false skip_picard_metrics = false skip_preseq = false diff --git a/nextflow_schema.json b/nextflow_schema.json index ad9c90f75..f7198db55 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -352,6 +352,11 @@ "type": "boolean", "description": "Skip MultiQC.", "fa_icon": "fas fa-fast-forward" + }, + "skip_qc": { + "type": "boolean", + "fa_icon": "fas fa-fast-forward", + "description": "Skip all QC steps except for MultiQC." } } }, From eaa75efce6a096565809eba6161ae838405be60a Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 25 Oct 2021 12:44:00 +0200 Subject: [PATCH 215/538] Get rid of functions not used --- modules/local/genome_blacklist_regions.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/modules/local/genome_blacklist_regions.nf b/modules/local/genome_blacklist_regions.nf index e28a749b9..35d0610ae 100644 --- a/modules/local/genome_blacklist_regions.nf +++ b/modules/local/genome_blacklist_regions.nf @@ -1,5 +1,5 @@ // Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' +include { saveFiles; getProcessName } from './functions' params.options = [:] From 409c27508acf9a0d3aaa48af0433f4085113e5cb Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 25 Oct 2021 14:33:02 +0200 Subject: [PATCH 216/538] Plug back align_bwa_mem subworkflow --- subworkflows/nf-core/align_bwa_mem.nf | 6 +++--- workflows/chipseq.nf | 24 +++++++++++------------- 2 files changed, 14 insertions(+), 16 deletions(-) diff --git a/subworkflows/nf-core/align_bwa_mem.nf b/subworkflows/nf-core/align_bwa_mem.nf index 44a9942cb..98c73149e 100644 --- a/subworkflows/nf-core/align_bwa_mem.nf +++ b/subworkflows/nf-core/align_bwa_mem.nf @@ -12,14 +12,14 @@ include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' workflow ALIGN_BWA_MEM { take: - ch_reads // channel: [ val(meta), [ reads ] ] - ch_index // path: /path/to/index + reads // channel: [ val(meta), [ reads ] ] + index // path: /path/to/index main: ch_versions = Channel.empty() - BWA_MEM(ch_reads, ch_index) + BWA_MEM(reads, index) BAM_SORT_SAMTOOLS(BWA_MEM.out.bam) ch_versions = ch_versions.mix(BWA_MEM.out.versions.first(), diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 4e7d4aa09..310877e49 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -161,7 +161,7 @@ trimgalore_options.args += params.trim_nextseq > 0 ? Utils.joinModuleArgs(["--n if (params.save_trimmed) { trimgalore_options.publish_files.put('fq.gz','') } include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' addParams( fastqc_options: modules['fastqc'], trimgalore_options: trimgalore_options ) -// include { ALIGN_BWA_MEM } from '../subworkflows/nf-core/align_bwa_mem' addParams( bwa_mem_options: modules['bwa_mem'], samtools_sort_options: modules['samtools_sort_lib'], samtools_index_options: modules['samtools_sort_lib'], samtools_stats_options: modules['samtools_sort_lib'] ) +include { ALIGN_BWA_MEM } from '../subworkflows/nf-core/align_bwa_mem' addParams( bwa_mem_options: modules['bwa_mem'], samtools_sort_options: modules['samtools_sort_lib'], samtools_index_options: modules['samtools_sort_lib'], samtools_stats_options: modules['samtools_sort_lib'] ) // include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' addParams( markduplicates_options: modules['picard_markduplicates'], samtools_index_options: modules['samtools_sort_merged_lib'] , samtools_stats_options: modules['samtools_sort_merged_lib'] ) /* @@ -202,18 +202,16 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(FASTQC_TRIMGALORE.out.versions) - // // - // // SUBWORKFLOW: Map reads & BAM QC - // // - // score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' - // params.modules['bwa_mem'].args += score - // MAP_BWA_MEM ( - // FASTQC_TRIMGALORE.out.reads, - // ch_index - // ) - // // ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.bwa_versions.first()) - // // ch_software_versions = ch_software_versions.mix(MAP_BWA_MEM.out.samtools_versions.first().ifEmpty(null)) - // ch_versions = ch_versions.mix(MAP_BWA_MEM.out.versions) + // + // SUBWORKFLOW: Map reads & BAM QC + // + score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' + params.modules['bwa_mem'].args += score + ALIGN_BWA_MEM ( + FASTQC_TRIMGALORE.out.reads, + PREPARE_GENOME.out.bwa_index + ) + ch_versions = ch_versions.mix(ALIGN_BWA_MEM.out.versions.first()) // // // // SUBWORKFLOW: Merge resequenced BAM files From e180008d944bffd63691815008be542f3e24fa84 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 25 Oct 2021 17:12:54 +0200 Subject: [PATCH 217/538] Add mark_duplicates_picard --- conf/modules.config | 6 +- .../nf-core/mark_duplicates_picard.nf | 36 +++++++----- workflows/chipseq.nf | 58 ++++++++++--------- 3 files changed, 56 insertions(+), 44 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 24c18c3a3..60e19e047 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -56,9 +56,11 @@ params { publish_dir = "bwa/mergedLibrary" suffix = ".mLb.mkD.sorted" } - 'samtools_sort_merged_lib' { - publish_dir = "bwa/mergedLibrary" + 'picard_markduplicates_samtools' { + args = '' suffix = ".mLb.mkD.sorted" + publish_files = ['bai':'', 'stats':'samtools_stats', 'flagstat':'samtools_stats', 'idxstats':'samtools_stats'] + publish_dir = "bwa/mergedLibrary" } 'bam_filter' { publish_dir = "bwa/mergedLibrary" diff --git a/subworkflows/nf-core/mark_duplicates_picard.nf b/subworkflows/nf-core/mark_duplicates_picard.nf index 9f8e53608..af2a944e5 100644 --- a/subworkflows/nf-core/mark_duplicates_picard.nf +++ b/subworkflows/nf-core/mark_duplicates_picard.nf @@ -11,27 +11,35 @@ include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' workflow MARK_DUPLICATES_PICARD { take: - ch_bam // channel: [ val(meta), [ bam ] ] + bam // channel: [ val(meta), [ bam ] ] main: ch_versions = Channel.empty() - PICARD_MARKDUPLICATES(ch_bam) + // + // Picard MarkDuplicates + // + PICARD_MARKDUPLICATES(bam) + ch_versions = ch_versions.mix(PICARD_MARKDUPLICATES.out.versions.first()) + + // + // Index BAM file and run samtools stats, flagstat and idxstats + // SAMTOOLS_INDEX(PICARD_MARKDUPLICATES.out.bam) - BAM_STATS_SAMTOOLS(PICARD_MARKDUPLICATES.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0])) + ch_versions = ch_versions.mix(SAMTOOLS_INDEX.out.versions.first()) - ch_versions = ch_versions.mix(PICARD_MARKDUPLICATES.out.versions.first(), - SAMTOOLS_INDEX.out.versions.first(), - BAM_STATS_SAMTOOLS.out.versions) + BAM_STATS_SAMTOOLS(PICARD_MARKDUPLICATES.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0])) + ch_versions = ch_versions.mix(BAM_STATS_SAMTOOLS.out.versions) emit: - bam = PICARD_MARKDUPLICATES.out.bam // channel: [ val(meta), [ bam ] ] - metrics = PICARD_MARKDUPLICATES.out.metrics // channel: [ val(meta), [ metrics ] ] - bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] - stats = BAM_STATS_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = BAM_STATS_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = BAM_STATS_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - - versions = ch_versions // path: versions.yml + bam = PICARD_MARKDUPLICATES.out.bam // channel: [ val(meta), [ bam ] ] + metrics = PICARD_MARKDUPLICATES.out.metrics // channel: [ val(meta), [ metrics ] ] + + bai = SAMTOOLS_INDEX.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_STATS_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_STATS_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_STATS_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + + versions = ch_versions // channel: [ versions.yml ] } diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 310877e49..16d976fdc 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -136,7 +136,7 @@ include { PREPARE_GENOME } from '../subworkflows/local/prepare_genome' addParams // def homer_annotatepeaks_consensus_options = modules['homer_annotatepeaks_consensus'] // homer_annotatepeaks_consensus_options['publish_dir'] += "/$peakType/consensus" -// include { PICARD_MERGESAMFILES } from '../modules/nf-core/modules/picard/mergesamfiles/main' addParams( options: modules['picard_mergesamfiles'] ) +include { PICARD_MERGESAMFILES } from '../modules/nf-core/modules/picard/mergesamfiles/main' addParams( options: modules['picard_mergesamfiles'] ) // include { PICARD_COLLECTMULTIPLEMETRICS } from '../modules/nf-core/modules/picard/collectmultiplemetrics/main' addParams( options: modules['picard_collectmultiplemetrics'] ) // include { PRESEQ_LCEXTRAP } from '../modules/nf-core/modules/preseq/lcextrap/main' addParams( options: modules['preseq_lcextrap'] ) // include { UCSC_BEDGRAPHTOBIGWIG } from '../modules/nf-core/modules/ucsc/bedgraphtobigwig/main' addParams( options: modules['ucsc_bedgraphtobigwig'] ) @@ -160,9 +160,12 @@ def trimgalore_options = modules['trimgalore'] trimgalore_options.args += params.trim_nextseq > 0 ? Utils.joinModuleArgs(["--nextseq ${params.trim_nextseq}"]) : '' if (params.save_trimmed) { trimgalore_options.publish_files.put('fq.gz','') } + +def picard_markduplicates_samtools = modules['picard_markduplicates_samtools'] + include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' addParams( fastqc_options: modules['fastqc'], trimgalore_options: trimgalore_options ) include { ALIGN_BWA_MEM } from '../subworkflows/nf-core/align_bwa_mem' addParams( bwa_mem_options: modules['bwa_mem'], samtools_sort_options: modules['samtools_sort_lib'], samtools_index_options: modules['samtools_sort_lib'], samtools_stats_options: modules['samtools_sort_lib'] ) -// include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' addParams( markduplicates_options: modules['picard_markduplicates'], samtools_index_options: modules['samtools_sort_merged_lib'] , samtools_stats_options: modules['samtools_sort_merged_lib'] ) +include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' addParams( markduplicates_options: modules['picard_markduplicates'], samtools_index_options: picard_markduplicates_samtools, samtools_stats_options: picard_markduplicates_samtools ) /* ======================================================================================== @@ -213,33 +216,32 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(ALIGN_BWA_MEM.out.versions.first()) - // // - // // SUBWORKFLOW: Merge resequenced BAM files - // // - // MAP_BWA_MEM - // .out - // .bam - // .map { - // meta, bam -> - // fmeta = meta.findAll { it.key != 'read_group' } - // fmeta.id = fmeta.id.split('_')[0..-2].join('_') - // [ fmeta, bam ] } - // .groupTuple(by: [0]) - // .map { it -> [ it[0], it[1].flatten() ] } - // .set { ch_sort_bam } - - // PICARD_MERGESAMFILES ( - // ch_sort_bam - // ) - // // ch_software_versions = ch_software_versions.mix(PICARD_MERGESAMFILES.out.versions.first().ifEmpty(null)) - // ch_versions = ch_versions.mix(PICARD_MERGESAMFILES.out.versions) + // + // SUBWORKFLOW: Merge resequenced BAM files + // + ALIGN_BWA_MEM + .out + .bam + .map { + meta, bam -> + fmeta = meta.findAll { it.key != 'read_group' } + fmeta.id = fmeta.id.split('_')[0..-2].join('_') + [ fmeta, bam ] } + .groupTuple(by: [0]) + .map { it -> [ it[0], it[1].flatten() ] } + .set { ch_sort_bam } + + PICARD_MERGESAMFILES ( + ch_sort_bam + ) + ch_versions = ch_versions.mix(PICARD_MERGESAMFILES.out.versions.first().ifEmpty(null)) - // // - // // SUBWORKFLOW: Mark duplicates & filter BAM files - // // - // MARK_DUPLICATES_PICARD ( - // PICARD_MERGESAMFILES.out.bam - // ) + // + // SUBWORKFLOW: Mark duplicates & filter BAM files + // + MARK_DUPLICATES_PICARD ( + PICARD_MERGESAMFILES.out.bam + ) // // // // SUBWORKFLOW: Fix getting name sorted BAM here for PE/SE From dc48c21f684954c273017716586def68b463971d Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 11:43:24 +0200 Subject: [PATCH 218/538] Adding filter_bam_bamtools subworkflow --- modules/local/bam_filter.nf | 4 +-- modules/local/bam_remove_orphans.nf | 4 +-- subworkflows/local/filter_bam_bamtools.nf | 10 +++---- subworkflows/local/prepare_genome.nf | 2 +- workflows/chipseq.nf | 32 ++++++++++++++--------- 5 files changed, 29 insertions(+), 23 deletions(-) diff --git a/modules/local/bam_filter.nf b/modules/local/bam_filter.nf index 2d255a79d..1c7f1b807 100644 --- a/modules/local/bam_filter.nf +++ b/modules/local/bam_filter.nf @@ -1,5 +1,5 @@ // Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' +include { initOptions; saveFiles; getProcessName } from './functions' params.options = [:] options = initOptions(params.options) @@ -12,7 +12,7 @@ process BAM_FILTER { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::bamtools=2.4.0 bioconda::samtools=1.4.1" : null) //TODO Create updated mulled container if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { diff --git a/modules/local/bam_remove_orphans.nf b/modules/local/bam_remove_orphans.nf index a0505db93..16b90e924 100644 --- a/modules/local/bam_remove_orphans.nf +++ b/modules/local/bam_remove_orphans.nf @@ -1,5 +1,5 @@ // Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' +include { initOptions; saveFiles; getProcessName } from './functions' params.options = [:] options = initOptions(params.options) @@ -12,7 +12,7 @@ process BAM_REMOVE_ORPHANS { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "${baseDir}/environment.yml" : null) // conda (params.enable_conda ? "conda-forge::python=3.7.6 bioconda::samtools=1.9" : null) //TODO Create updated mulled container diff --git a/subworkflows/local/filter_bam_bamtools.nf b/subworkflows/local/filter_bam_bamtools.nf index 63da2f8f8..4bcbb4f53 100644 --- a/subworkflows/local/filter_bam_bamtools.nf +++ b/subworkflows/local/filter_bam_bamtools.nf @@ -9,14 +9,14 @@ params.samtools_stats_options = [:] include { BAM_FILTER } from '../../modules/local/bam_filter' addParams( options: params.bam_filter_options ) include { BAM_REMOVE_ORPHANS } from '../../modules/local/bam_remove_orphans' addParams( options: params.bam_remove_orphans_options ) -include { BAM_SORT_SAMTOOLS } from '../nf-core/bam_sort_samtools' addParams( sort_options: params.samtools_sort_options, index_options: params.samtools_index_options, stats_options: params.samtools_stats_options ) +include { BAM_SORT_SAMTOOLS } from '../nf-core/bam_sort_samtools' addParams( sort_options: params.samtools_sort_options, index_options: params.samtools_index_options, stats_options: params.samtools_stats_options ) workflow FILTER_BAM_BAMTOOLS { take: - ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] - ch_bed // channel: [ bed ] - bamtools_filter_se_config // file: BAMtools filter JSON config file for SE data - bamtools_filter_pe_config // file: BAMtools filter JSON config file for PE data + ch_bam_bai // channel: [ val(meta), [ bam ], [bai] ] + ch_bed // channel: [ bed ] + bamtools_filter_se_config // file: BAMtools filter JSON config file for SE data + bamtools_filter_pe_config // file: BAMtools filter JSON config file for PE data main: diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index a8241dab2..b07065e7b 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -67,7 +67,7 @@ workflow PREPARE_GENOME { ch_blacklist = GUNZIP_BLACKLIST ( params.blacklist ).gunzip ch_versions = ch_versions.mix(GUNZIP_BLACKLIST.out.versions) } else { - ch_blacklist = file(params.blacklist) + ch_blacklist = Channel.fromPath(file(params.blacklist)) } } diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 16d976fdc..82143a087 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -105,7 +105,13 @@ include { PREPARE_GENOME } from '../subworkflows/local/prepare_genome' addParams gffread_options : gffread_options, bwa_index_options : bwa_index_options ) -// include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' addParams( bam_filter_options: modules['bam_filter'], bam_remove_orphans_options: modules['bam_remove_orphans'], samtools_sort_options: modules['samtools_sort_filter'], samtools_index_options: modules['samtools_sort_filter'], samtools_stats_options: modules['samtools_sort_filter'] ) +include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' addParams( + bam_filter_options : modules['bam_filter'], + bam_remove_orphans_options: modules['bam_remove_orphans'], + samtools_sort_options : modules['samtools_sort_filter'], + samtools_index_options : modules['samtools_sort_filter'], + samtools_stats_options : modules['samtools_sort_filter'] +) /* ======================================================================================== @@ -237,23 +243,23 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(PICARD_MERGESAMFILES.out.versions.first().ifEmpty(null)) // - // SUBWORKFLOW: Mark duplicates & filter BAM files + // SUBWORKFLOW: Mark duplicates & filter BAM files after merging // MARK_DUPLICATES_PICARD ( PICARD_MERGESAMFILES.out.bam ) - // // - // // SUBWORKFLOW: Fix getting name sorted BAM here for PE/SE - // // - // BAM_CLEAN ( - // MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), - // MAKE_GENOME_FILTER.out.bed.collect(), - // ch_bamtools_filter_se_config, - // ch_bamtools_filter_pe_config - // ) - // // ch_software_versions = ch_software_versions.mix(BAM_CLEAN.out.bamtools_versions.first().ifEmpty(null)) - // ch_versions = ch_versions.mix(BAM_CLEAN.out.versions) + // + // SUBWORKFLOW: Fix getting name sorted BAM here for PE/SE + // + FILTER_BAM_BAMTOOLS ( + MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), + PREPARE_GENOME.out.blacklist.first(), + ch_bamtools_filter_se_config, + ch_bamtools_filter_pe_config + ) + ch_versions = ch_versions.mix(FILTER_BAM_BAMTOOLS.out.versions.first().ifEmpty(null)) + // // // // MODULE: Post alignment QC From 9d1ce2a251dca603a4c4696f91eb642cfb43386f Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 12:16:16 +0200 Subject: [PATCH 219/538] Fix filter_bam_bamtools only executed once --- workflows/chipseq.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 82143a087..517f08110 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -254,7 +254,7 @@ workflow CHIPSEQ { // FILTER_BAM_BAMTOOLS ( MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), - PREPARE_GENOME.out.blacklist.first(), + PREPARE_GENOME.out.blacklist.ifEmpty([]).first(), ch_bamtools_filter_se_config, ch_bamtools_filter_pe_config ) From 8ce233dc84edaf974918aa4d5b29ccf919722e7e Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 12:27:04 +0200 Subject: [PATCH 220/538] Add picard_collectmultiplemetrics module --- subworkflows/local/prepare_genome.nf | 2 +- workflows/chipseq.nf | 19 +++++++++---------- 2 files changed, 10 insertions(+), 11 deletions(-) diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index b07065e7b..1e776669f 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -134,7 +134,7 @@ workflow PREPARE_GENOME { gtf = ch_gtf // path: genome.gtf gene_bed = ch_gene_bed // path: gene.bed chrom_sizes = ch_chrom_sizes // path: genome.sizes - blacklist = ch_blacklist // path: blaclist.bed + blacklist = ch_blacklist // path: blacklist.bed bwa_index = ch_bwa_index // path: bbsplit/index/ versions = ch_versions.ifEmpty(null) // channel: [ versions.yml ] diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 517f08110..0d56d25b2 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -143,7 +143,7 @@ include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' // homer_annotatepeaks_consensus_options['publish_dir'] += "/$peakType/consensus" include { PICARD_MERGESAMFILES } from '../modules/nf-core/modules/picard/mergesamfiles/main' addParams( options: modules['picard_mergesamfiles'] ) -// include { PICARD_COLLECTMULTIPLEMETRICS } from '../modules/nf-core/modules/picard/collectmultiplemetrics/main' addParams( options: modules['picard_collectmultiplemetrics'] ) +include { PICARD_COLLECTMULTIPLEMETRICS } from '../modules/nf-core/modules/picard/collectmultiplemetrics/main' addParams( options: modules['picard_collectmultiplemetrics'] ) // include { PRESEQ_LCEXTRAP } from '../modules/nf-core/modules/preseq/lcextrap/main' addParams( options: modules['preseq_lcextrap'] ) // include { UCSC_BEDGRAPHTOBIGWIG } from '../modules/nf-core/modules/ucsc/bedgraphtobigwig/main' addParams( options: modules['ucsc_bedgraphtobigwig'] ) // include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/modules/deeptools/computematrix/main' addParams( options: modules['deeptools_computematrix'] ) @@ -261,15 +261,14 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(FILTER_BAM_BAMTOOLS.out.versions.first().ifEmpty(null)) - // // - // // MODULE: Post alignment QC - // // - // PICARD_COLLECTMULTIPLEMETRICS ( - // BAM_CLEAN.out.bam, - // ch_fasta - // ) - - // // TODO Add versions to picard collectmultiplemetrics + // + // MODULE: Post alignment QC + // + PICARD_COLLECTMULTIPLEMETRICS ( + FILTER_BAM_BAMTOOLS.out.bam, + PREPARE_GENOME.out.fasta + ) + ch_versions = ch_versions.mix(PICARD_COLLECTMULTIPLEMETRICS.out.versions.first()) // // // // MODULE: Library coverage From e75a4c4201a7417c9023f3ddfc5e5b4579548f40 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 13:22:02 +0200 Subject: [PATCH 221/538] Adding preseq_lcextrap module back --- workflows/chipseq.nf | 17 ++++++++--------- 1 file changed, 8 insertions(+), 9 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 0d56d25b2..5d36f75a3 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -144,7 +144,7 @@ include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' include { PICARD_MERGESAMFILES } from '../modules/nf-core/modules/picard/mergesamfiles/main' addParams( options: modules['picard_mergesamfiles'] ) include { PICARD_COLLECTMULTIPLEMETRICS } from '../modules/nf-core/modules/picard/collectmultiplemetrics/main' addParams( options: modules['picard_collectmultiplemetrics'] ) -// include { PRESEQ_LCEXTRAP } from '../modules/nf-core/modules/preseq/lcextrap/main' addParams( options: modules['preseq_lcextrap'] ) +include { PRESEQ_LCEXTRAP } from '../modules/nf-core/modules/preseq/lcextrap/main' addParams( options: modules['preseq_lcextrap'] ) // include { UCSC_BEDGRAPHTOBIGWIG } from '../modules/nf-core/modules/ucsc/bedgraphtobigwig/main' addParams( options: modules['ucsc_bedgraphtobigwig'] ) // include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/modules/deeptools/computematrix/main' addParams( options: modules['deeptools_computematrix'] ) // include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/modules/deeptools/plotprofile/main' addParams( options: modules['deeptools_plotprofile'] ) @@ -270,14 +270,13 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(PICARD_COLLECTMULTIPLEMETRICS.out.versions.first()) - // // - // // MODULE: Library coverage - // // - // PRESEQ_LCEXTRAP ( - // BAM_CLEAN.out.bam - // ) - // // ch_software_versions = ch_software_versions.mix(PRESEQ_LCEXTRAP.out.versions.first().ifEmpty(null)) - // ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions) + // + // MODULE: Library coverage + // + PRESEQ_LCEXTRAP ( + FILTER_BAM_BAMTOOLS.out.bam + ) + ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions.first()) // // // // MODULE: Strand cross-correlation From e3c6ce1b1e505435c424509b476837afee90fb4b Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 14:39:55 +0200 Subject: [PATCH 222/538] Add bedtools_genomecov module back --- modules/local/bedtools_genomecov.nf | 1 - workflows/chipseq.nf | 33 +++++++++++++++-------------- 2 files changed, 17 insertions(+), 17 deletions(-) diff --git a/modules/local/bedtools_genomecov.nf b/modules/local/bedtools_genomecov.nf index f847f12c5..95b54e49d 100644 --- a/modules/local/bedtools_genomecov.nf +++ b/modules/local/bedtools_genomecov.nf @@ -27,7 +27,6 @@ process BEDTOOLS_GENOMECOV { path "versions.yml" , emit: versions script: - def software = getSoftwareName(task.process) def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" def pe = meta.single_end ? '' : '-pc' diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 5d36f75a3..ba8a5e133 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -74,7 +74,7 @@ def modules = params.modules.clone() // multiqc_options.args += params.multiqc_title ? Utils.joinModuleArgs(["--title \"$params.multiqc_title\""]) : '' // multiqc_options.publish_dir += "/$peakType" -// include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_genomecov' addParams( options: modules['bedtools_genomecov'] ) +include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_genomecov' addParams( options: modules['bedtools_genomecov'] ) // include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' addParams( options: plot_homer_annotatepeaks_options ) // include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' addParams( options: plot_macs2_qc_options ) // include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' addParams( options: macs2_consensus_options ) @@ -145,12 +145,12 @@ include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' include { PICARD_MERGESAMFILES } from '../modules/nf-core/modules/picard/mergesamfiles/main' addParams( options: modules['picard_mergesamfiles'] ) include { PICARD_COLLECTMULTIPLEMETRICS } from '../modules/nf-core/modules/picard/collectmultiplemetrics/main' addParams( options: modules['picard_collectmultiplemetrics'] ) include { PRESEQ_LCEXTRAP } from '../modules/nf-core/modules/preseq/lcextrap/main' addParams( options: modules['preseq_lcextrap'] ) +include { PHANTOMPEAKQUALTOOLS } from '../modules/nf-core/modules/phantompeakqualtools/main' addParams( options: modules['phantompeakqualtools'] ) // include { UCSC_BEDGRAPHTOBIGWIG } from '../modules/nf-core/modules/ucsc/bedgraphtobigwig/main' addParams( options: modules['ucsc_bedgraphtobigwig'] ) // include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/modules/deeptools/computematrix/main' addParams( options: modules['deeptools_computematrix'] ) // include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/modules/deeptools/plotprofile/main' addParams( options: modules['deeptools_plotprofile'] ) // include { DEEPTOOLS_PLOTHEATMAP } from '../modules/nf-core/modules/deeptools/plotheatmap/main' addParams( options: modules['deeptools_plotheatmap'] ) // include { DEEPTOOLS_PLOTFINGERPRINT } from '../modules/nf-core/modules/deeptools/plotfingerprint/main' addParams( options: deeptools_plotfingerprint_options ) -// include { PHANTOMPEAKQUALTOOLS } from '../modules/nf-core/modules/phantompeakqualtools/main' addParams( options: modules['phantompeakqualtools'] ) // include { MACS2_CALLPEAK } from '../modules/nf-core/modules/macs2/callpeak/main' addParams( options: macs2_callpeak_options ) // include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/modules/subread/featurecounts/main' addParams( options: subread_featurecounts_options ) include { CUSTOM_DUMPSOFTWAREVERSIONS } from '../modules/nf-core/modules/custom/dumpsoftwareversions/main' addParams( options: [publish_files : ['_versions.yml':'']] ) @@ -278,14 +278,14 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions.first()) - // // - // // MODULE: Strand cross-correlation - // // - // PHANTOMPEAKQUALTOOLS ( - // BAM_CLEAN.out.bam - // ) - // // ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions.first().ifEmpty(null)) - // ch_versions = ch_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions) + // + // MODULE: Strand cross-correlation + // + PHANTOMPEAKQUALTOOLS ( + FILTER_BAM_BAMTOOLS.out.bam + ) + // ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions.first().ifEmpty(null)) + ch_versions = ch_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions.first()) // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( // PHANTOMPEAKQUALTOOLS.out.spp.join(PHANTOMPEAKQUALTOOLS.out.rdata, by: [0]), @@ -294,12 +294,13 @@ workflow CHIPSEQ { // ch_spp_correlation_header // ) - // // - // // MODULE: Coverage tracks - // // - // BEDTOOLS_GENOMECOV ( - // BAM_CLEAN.out.bam.join(BAM_CLEAN.out.flagstat, by: [0]) - // ) + // + // MODULE: Coverage tracks + // + BEDTOOLS_GENOMECOV ( + FILTER_BAM_BAMTOOLS.out.bam.join(FILTER_BAM_BAMTOOLS.out.flagstat, by: [0]) + ) + ch_versions = ch_versions.mix(BEDTOOLS_GENOMECOV.out.versions.first()) // // // // MODULE: Coverage tracks From d66b4b1f216511576b7f29eea12a044072005a91 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 15:01:08 +0200 Subject: [PATCH 223/538] Add ucsc_bedgraphtobigwig back --- workflows/chipseq.nf | 20 +++++++++----------- 1 file changed, 9 insertions(+), 11 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index ba8a5e133..4f44be2c3 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -146,7 +146,7 @@ include { PICARD_MERGESAMFILES } from '../modules/nf-core/modules/picar include { PICARD_COLLECTMULTIPLEMETRICS } from '../modules/nf-core/modules/picard/collectmultiplemetrics/main' addParams( options: modules['picard_collectmultiplemetrics'] ) include { PRESEQ_LCEXTRAP } from '../modules/nf-core/modules/preseq/lcextrap/main' addParams( options: modules['preseq_lcextrap'] ) include { PHANTOMPEAKQUALTOOLS } from '../modules/nf-core/modules/phantompeakqualtools/main' addParams( options: modules['phantompeakqualtools'] ) -// include { UCSC_BEDGRAPHTOBIGWIG } from '../modules/nf-core/modules/ucsc/bedgraphtobigwig/main' addParams( options: modules['ucsc_bedgraphtobigwig'] ) +include { UCSC_BEDGRAPHTOBIGWIG } from '../modules/nf-core/modules/ucsc/bedgraphtobigwig/main' addParams( options: modules['ucsc_bedgraphtobigwig'] ) // include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/modules/deeptools/computematrix/main' addParams( options: modules['deeptools_computematrix'] ) // include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/modules/deeptools/plotprofile/main' addParams( options: modules['deeptools_plotprofile'] ) // include { DEEPTOOLS_PLOTHEATMAP } from '../modules/nf-core/modules/deeptools/plotheatmap/main' addParams( options: modules['deeptools_plotheatmap'] ) @@ -284,7 +284,6 @@ workflow CHIPSEQ { PHANTOMPEAKQUALTOOLS ( FILTER_BAM_BAMTOOLS.out.bam ) - // ch_software_versions = ch_software_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions.first().ifEmpty(null)) ch_versions = ch_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions.first()) // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( @@ -302,15 +301,14 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(BEDTOOLS_GENOMECOV.out.versions.first()) - // // - // // MODULE: Coverage tracks - // // - // UCSC_BEDGRAPHTOBIGWIG ( - // BEDTOOLS_GENOMECOV.out.bedgraph, - // GET_CHROM_SIZES.out.sizes - // ) - // // ch_software_versions = ch_software_versions.mix(UCSC_BEDGRAPHTOBIGWIG.out.versions.first().ifEmpty(null)) - // ch_versions = ch_versions.mix(UCSC_BEDGRAPHTOBIGWIG.out.versions) + // + // MODULE: Coverage tracks + // + UCSC_BEDGRAPHTOBIGWIG ( + BEDTOOLS_GENOMECOV.out.bedgraph, + PREPARE_GENOME.out.chrom_sizes + ) + ch_versions = ch_versions.mix(UCSC_BEDGRAPHTOBIGWIG.out.versions.first()) // // // // MODULE: Coverage plots From 621bb9a2ce550d1dbfb36b1f2045c2db9255558c Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 15:29:36 +0200 Subject: [PATCH 224/538] Add deeptools_computematrix module back --- workflows/chipseq.nf | 19 +++++++++---------- 1 file changed, 9 insertions(+), 10 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 4f44be2c3..e4cdcc614 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -147,7 +147,7 @@ include { PICARD_COLLECTMULTIPLEMETRICS } from '../modules/nf-core/modules/picar include { PRESEQ_LCEXTRAP } from '../modules/nf-core/modules/preseq/lcextrap/main' addParams( options: modules['preseq_lcextrap'] ) include { PHANTOMPEAKQUALTOOLS } from '../modules/nf-core/modules/phantompeakqualtools/main' addParams( options: modules['phantompeakqualtools'] ) include { UCSC_BEDGRAPHTOBIGWIG } from '../modules/nf-core/modules/ucsc/bedgraphtobigwig/main' addParams( options: modules['ucsc_bedgraphtobigwig'] ) -// include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/modules/deeptools/computematrix/main' addParams( options: modules['deeptools_computematrix'] ) +include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/modules/deeptools/computematrix/main' addParams( options: modules['deeptools_computematrix'] ) // include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/modules/deeptools/plotprofile/main' addParams( options: modules['deeptools_plotprofile'] ) // include { DEEPTOOLS_PLOTHEATMAP } from '../modules/nf-core/modules/deeptools/plotheatmap/main' addParams( options: modules['deeptools_plotheatmap'] ) // include { DEEPTOOLS_PLOTFINGERPRINT } from '../modules/nf-core/modules/deeptools/plotfingerprint/main' addParams( options: deeptools_plotfingerprint_options ) @@ -310,15 +310,14 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(UCSC_BEDGRAPHTOBIGWIG.out.versions.first()) - // // - // // MODULE: Coverage plots - // // - // DEEPTOOLS_COMPUTEMATRIX ( - // UCSC_BEDGRAPHTOBIGWIG.out.bigwig, - // ch_gene_bed - // ) - // // ch_software_versions = ch_software_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first().ifEmpty(null)) - // ch_versions = ch_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions) + // + // MODULE: Coverage plots + // + DEEPTOOLS_COMPUTEMATRIX ( + UCSC_BEDGRAPHTOBIGWIG.out.bigwig, + PREPARE_GENOME.out.gene_bed + ) + ch_versions = ch_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first()) // DEEPTOOLS_PLOTPROFILE ( // DEEPTOOLS_COMPUTEMATRIX.out.matrix From 5530fe5f375dde5a23b35be672e3561f87128ce1 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 15:34:53 +0200 Subject: [PATCH 225/538] Add deeptools_plotheatmap module back --- workflows/chipseq.nf | 18 ++++++++++-------- 1 file changed, 10 insertions(+), 8 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index e4cdcc614..d741d4eb7 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -148,8 +148,8 @@ include { PRESEQ_LCEXTRAP } from '../modules/nf-core/modules/prese include { PHANTOMPEAKQUALTOOLS } from '../modules/nf-core/modules/phantompeakqualtools/main' addParams( options: modules['phantompeakqualtools'] ) include { UCSC_BEDGRAPHTOBIGWIG } from '../modules/nf-core/modules/ucsc/bedgraphtobigwig/main' addParams( options: modules['ucsc_bedgraphtobigwig'] ) include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/modules/deeptools/computematrix/main' addParams( options: modules['deeptools_computematrix'] ) -// include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/modules/deeptools/plotprofile/main' addParams( options: modules['deeptools_plotprofile'] ) -// include { DEEPTOOLS_PLOTHEATMAP } from '../modules/nf-core/modules/deeptools/plotheatmap/main' addParams( options: modules['deeptools_plotheatmap'] ) +include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/modules/deeptools/plotprofile/main' addParams( options: modules['deeptools_plotprofile'] ) +include { DEEPTOOLS_PLOTHEATMAP } from '../modules/nf-core/modules/deeptools/plotheatmap/main' addParams( options: modules['deeptools_plotheatmap'] ) // include { DEEPTOOLS_PLOTFINGERPRINT } from '../modules/nf-core/modules/deeptools/plotfingerprint/main' addParams( options: deeptools_plotfingerprint_options ) // include { MACS2_CALLPEAK } from '../modules/nf-core/modules/macs2/callpeak/main' addParams( options: macs2_callpeak_options ) // include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/modules/subread/featurecounts/main' addParams( options: subread_featurecounts_options ) @@ -319,13 +319,15 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first()) - // DEEPTOOLS_PLOTPROFILE ( - // DEEPTOOLS_COMPUTEMATRIX.out.matrix - // ) + DEEPTOOLS_PLOTPROFILE ( + DEEPTOOLS_COMPUTEMATRIX.out.matrix + ) + ch_versions = ch_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first()) - // DEEPTOOLS_PLOTHEATMAP ( - // DEEPTOOLS_COMPUTEMATRIX.out.matrix - // ) + DEEPTOOLS_PLOTHEATMAP ( + DEEPTOOLS_COMPUTEMATRIX.out.matrix + ) + ch_versions = ch_versions.mix(DEEPTOOLS_PLOTHEATMAP.out.versions.first()) // // // // Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] From 47d55b317e1404578c6bb1225aabe1df3b2ebc6e Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 16:02:19 +0200 Subject: [PATCH 226/538] Add deeptools_plotfingerpring module back --- workflows/chipseq.nf | 61 ++++++++++++++++++++++++-------------------- 1 file changed, 34 insertions(+), 27 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index d741d4eb7..18d48c597 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -123,8 +123,8 @@ include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' // MODULE: Installed directly from nf-core/modules // -// def deeptools_plotfingerprint_options = modules['deeptools_plotfingerprint'] -// deeptools_plotfingerprint_options.args += " --numberOfSamples $params.fingerprint_bins" +def deeptools_plotfingerprint_options = modules['deeptools_plotfingerprint'] +deeptools_plotfingerprint_options.args += " --numberOfSamples $params.fingerprint_bins" // def macs2_callpeak_options = modules['macs2_callpeak'] // macs2_callpeak_options.args += params.narrow_peak ? '' : Utils.joinModuleArgs(['--broad', "--broad-cutoff ${params.broad_cutoff}"]) @@ -150,7 +150,7 @@ include { UCSC_BEDGRAPHTOBIGWIG } from '../modules/nf-core/modules/ucsc/ include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/modules/deeptools/computematrix/main' addParams( options: modules['deeptools_computematrix'] ) include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/modules/deeptools/plotprofile/main' addParams( options: modules['deeptools_plotprofile'] ) include { DEEPTOOLS_PLOTHEATMAP } from '../modules/nf-core/modules/deeptools/plotheatmap/main' addParams( options: modules['deeptools_plotheatmap'] ) -// include { DEEPTOOLS_PLOTFINGERPRINT } from '../modules/nf-core/modules/deeptools/plotfingerprint/main' addParams( options: deeptools_plotfingerprint_options ) +include { DEEPTOOLS_PLOTFINGERPRINT } from '../modules/nf-core/modules/deeptools/plotfingerprint/main' addParams( options: deeptools_plotfingerprint_options ) // include { MACS2_CALLPEAK } from '../modules/nf-core/modules/macs2/callpeak/main' addParams( options: macs2_callpeak_options ) // include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/modules/subread/featurecounts/main' addParams( options: subread_featurecounts_options ) include { CUSTOM_DUMPSOFTWAREVERSIONS } from '../modules/nf-core/modules/custom/dumpsoftwareversions/main' addParams( options: [publish_files : ['_versions.yml':'']] ) @@ -329,31 +329,38 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(DEEPTOOLS_PLOTHEATMAP.out.versions.first()) - // // - // // Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] - // // - // BAM_CLEAN - // .out - // .bam - // .join ( BAM_CLEAN.out.bai, by: [0] ) - // .map { meta, bam, bai -> meta.control ? null : [ meta.id, [ bam ] , [ bai ] ] } - // .set { ch_control_bam_bai } - - // BAM_CLEAN - // .out - // .bam - // .join ( BAM_CLEAN.out.bai, by: [0] ) - // .map { meta, bam, bai -> meta.control ? [ meta.control, meta, [ bam ], [ bai ] ] : null } - // .combine(ch_control_bam_bai, by: 0) - // .map { it -> [ it[1] , it[2] + it[4], it[3] + it[5] ] } - // .set { ch_ip_control_bam_bai } + // + // Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] + // + FILTER_BAM_BAMTOOLS + .out + .bam + .join (FILTER_BAM_BAMTOOLS.out.bai, by: [0]) + .map { + meta, bam, bai -> + meta.control ? null : [ meta.id, [ bam ] , [ bai ] ] + } + .set { ch_control_bam_bai } - // // - // // plotFingerprint for IP and control together - // // - // DEEPTOOLS_PLOTFINGERPRINT ( - // ch_ip_control_bam_bai - // ) + FILTER_BAM_BAMTOOLS + .out + .bam + .join (FILTER_BAM_BAMTOOLS.out.bai, by: [0]) + .map { + meta, bam, bai -> + meta.control ? [ meta.control, meta, [ bam ], [ bai ] ] : null + } + .combine(ch_control_bam_bai, by: 0) + .map { it -> [ it[1] , it[2] + it[4], it[3] + it[5] ] } + .set { ch_ip_control_bam_bai } + + // + // plotFingerprint for IP and control together + // + DEEPTOOLS_PLOTFINGERPRINT ( + ch_ip_control_bam_bai + ) + ch_versions = ch_versions.mix(DEEPTOOLS_PLOTFINGERPRINT.out.versions.first()) // if (params.macs_gsize) { From 426aedb9494a74d3b1ff6fd5a45fb85f2f675fb7 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 16:16:04 +0200 Subject: [PATCH 227/538] Add macs2_callpeak and frip_score modules --- modules/local/frip_score.nf | 4 +- workflows/chipseq.nf | 74 +++++++++++++++++++------------------ 2 files changed, 40 insertions(+), 38 deletions(-) diff --git a/modules/local/frip_score.nf b/modules/local/frip_score.nf index 836dba71e..7294d08af 100644 --- a/modules/local/frip_score.nf +++ b/modules/local/frip_score.nf @@ -1,5 +1,5 @@ // Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' +include { initOptions; saveFiles; getProcessName } from './functions' params.options = [:] options = initOptions(params.options) @@ -9,7 +9,7 @@ process FRIP_SCORE { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::bedtools=2.30.0 bioconda::samtools=1.9" : null) //TODO Create updated mulled container if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 18d48c597..cea8fc1c7 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -75,10 +75,11 @@ def modules = params.modules.clone() // multiqc_options.publish_dir += "/$peakType" include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_genomecov' addParams( options: modules['bedtools_genomecov'] ) +include { FRIP_SCORE } from '../modules/local/frip_score' addParams( options: modules['frip_score'] ) + // include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' addParams( options: plot_homer_annotatepeaks_options ) // include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' addParams( options: plot_macs2_qc_options ) // include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' addParams( options: macs2_consensus_options ) -// include { FRIP_SCORE } from '../modules/local/frip_score' addParams( options: modules['frip_score'] ) // //include { DESEQ2_QC } from '../modules/local/deseq2_qc' addParams( options: deseq2_qc_options, multiqc_label: 'star_salmon' ) // include { IGV } from '../modules/local/igv' addParams( options: [:] ) // include { MULTIQC } from '../modules/local/multiqc' addParams( options: multiqc_options ) // TODO review @@ -126,12 +127,12 @@ include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' def deeptools_plotfingerprint_options = modules['deeptools_plotfingerprint'] deeptools_plotfingerprint_options.args += " --numberOfSamples $params.fingerprint_bins" -// def macs2_callpeak_options = modules['macs2_callpeak'] -// macs2_callpeak_options.args += params.narrow_peak ? '' : Utils.joinModuleArgs(['--broad', "--broad-cutoff ${params.broad_cutoff}"]) -// macs2_callpeak_options.args += params.save_macs_pileup ? Utils.joinModuleArgs(['--bdg', '--SPMR']) : '' -// macs2_callpeak_options.args += params.macs_fdr ? Utils.joinModuleArgs(["--qvalue ${params.macs_fdr}"]) : '' -// macs2_callpeak_options.args += params.macs_pvalue ? Utils.joinModuleArgs(["--pvalue ${params.macs_pvalue}"]) : '' -// macs2_callpeak_options['publish_dir'] += "/$peakType" +def macs2_callpeak_options = modules['macs2_callpeak'] +macs2_callpeak_options.args += params.narrow_peak ? '' : Utils.joinModuleArgs(['--broad', "--broad-cutoff ${params.broad_cutoff}"]) +macs2_callpeak_options.args += params.save_macs_pileup ? Utils.joinModuleArgs(['--bdg', '--SPMR']) : '' +macs2_callpeak_options.args += params.macs_fdr ? Utils.joinModuleArgs(["--qvalue ${params.macs_fdr}"]) : '' +macs2_callpeak_options.args += params.macs_pvalue ? Utils.joinModuleArgs(["--pvalue ${params.macs_pvalue}"]) : '' +macs2_callpeak_options['publish_dir'] += "/$peakType" // def subread_featurecounts_options = modules['subread_featurecounts'] // subread_featurecounts_options['publish_dir'] += "/$peakType/consensus" @@ -151,7 +152,7 @@ include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/modules/deept include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/modules/deeptools/plotprofile/main' addParams( options: modules['deeptools_plotprofile'] ) include { DEEPTOOLS_PLOTHEATMAP } from '../modules/nf-core/modules/deeptools/plotheatmap/main' addParams( options: modules['deeptools_plotheatmap'] ) include { DEEPTOOLS_PLOTFINGERPRINT } from '../modules/nf-core/modules/deeptools/plotfingerprint/main' addParams( options: deeptools_plotfingerprint_options ) -// include { MACS2_CALLPEAK } from '../modules/nf-core/modules/macs2/callpeak/main' addParams( options: macs2_callpeak_options ) +include { MACS2_CALLPEAK } from '../modules/nf-core/modules/macs2/callpeak/main' addParams( options: macs2_callpeak_options ) // include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/modules/subread/featurecounts/main' addParams( options: subread_featurecounts_options ) include { CUSTOM_DUMPSOFTWAREVERSIONS } from '../modules/nf-core/modules/custom/dumpsoftwareversions/main' addParams( options: [publish_files : ['_versions.yml':'']] ) @@ -362,36 +363,37 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(DEEPTOOLS_PLOTFINGERPRINT.out.versions.first()) - // if (params.macs_gsize) { - - // // - // // Call peaks - // // - - // // Create channel: [ val(meta), ip_bam, control_bam ] - // ch_ip_control_bam_bai - // .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } - // .set { ch_ip_control_bam } + if (params.macs_gsize) { - // MACS2_CALLPEAK ( - // ch_ip_control_bam, - // params.macs_gsize - // ) - // // ch_software_versions = ch_software_versions.mix(MACS2_CALLPEAK.out.versions.first().ifEmpty(null)) - // ch_versions = ch_versions.mix(MACS2_CALLPEAK.out.versions) + // + // Call peaks + // - // ch_ip_control_bam - // .join(MACS2_CALLPEAK.out.peak, by: [0]) - // .map { it -> [ it[0], it[1], it[3] ] } - // .set { ch_ip_peak } - // FRIP_SCORE ( - // ch_ip_peak - // ) + // Create channel: [ val(meta), ip_bam, control_bam ] + ch_ip_control_bam_bai + .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } + .set { ch_ip_control_bam } + + MACS2_CALLPEAK ( + ch_ip_control_bam, + params.macs_gsize + ) + ch_versions = ch_versions.mix(MACS2_CALLPEAK.out.versions.first()) + + ch_ip_control_bam + .join(MACS2_CALLPEAK.out.peak, by: [0]) + .map { it -> [ it[0], it[1], it[3] ] } + .set { ch_ip_peak } + FRIP_SCORE ( + ch_ip_peak + ) + ch_versions = ch_versions.mix(FRIP_SCORE.out.versions.first()) + + // ch_ip_peak + // .join(FRIP_SCORE.out.txt, by: [0]) + // .map { it -> [ it[0], it[2], it[3] ] } + // .set { ch_ip_peak_frip } - // ch_ip_peak - // .join(FRIP_SCORE.out.txt, by: [0]) - // .map { it -> [ it[0], it[2], it[3] ] } - // .set { ch_ip_peak_frip } // MULTIQC_CUSTOM_PEAKS ( // ch_ip_peak_frip, // ch_peak_count_header, @@ -482,7 +484,7 @@ workflow CHIPSEQ { // // ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) // // ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) - // } + } // // // // Create IGV session From c13b3bd153cdfc82a1cdd2bf3700782bee5cb4dd Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 16:32:23 +0200 Subject: [PATCH 228/538] Add plot_macs2_qc module back --- modules/local/plot_macs2_qc.nf | 9 +++++---- workflows/chipseq.nf | 20 ++++++++++---------- 2 files changed, 15 insertions(+), 14 deletions(-) diff --git a/modules/local/plot_macs2_qc.nf b/modules/local/plot_macs2_qc.nf index 46327f3e6..e83a4f8a7 100644 --- a/modules/local/plot_macs2_qc.nf +++ b/modules/local/plot_macs2_qc.nf @@ -1,5 +1,5 @@ // Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' +include { initOptions; saveFiles; getProcessName } from './functions' params.options = [:] options = initOptions(params.options) @@ -11,7 +11,7 @@ process PLOT_MACS2_QC { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "${baseDir}/environment.yml" : null) //TODO Create updated mulled container @@ -19,8 +19,9 @@ process PLOT_MACS2_QC { path peaks output: - path '*.txt', emit: txt - path '*.pdf', emit: pdf + path '*.txt' , emit: txt + path '*.pdf' , emit: pdf + path "versions.yml", emit: versions script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index cea8fc1c7..7fc556706 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -61,12 +61,12 @@ ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering // Don't overwrite global params.modules, create a copy instead and use that within the main script. def modules = params.modules.clone() +def plot_macs2_qc_options = modules['plot_macs2_qc'] +plot_macs2_qc_options.publish_dir += "/$peakType/qc" + // def plot_homer_annotatepeaks_options = modules['plot_homer_annotatepeaks'] // plot_homer_annotatepeaks_options.publish_dir += "/$peakType/qc" -// def plot_macs2_qc_options = modules['plot_macs2_qc'] -// plot_macs2_qc_options.publish_dir += "/$peakType/qc" - // def macs2_consensus_options = modules['macs2_consensus'] // macs2_consensus_options.publish_dir += "/$peakType/qc" @@ -76,9 +76,8 @@ def modules = params.modules.clone() include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_genomecov' addParams( options: modules['bedtools_genomecov'] ) include { FRIP_SCORE } from '../modules/local/frip_score' addParams( options: modules['frip_score'] ) - +include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' addParams( options: plot_macs2_qc_options ) // include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' addParams( options: plot_homer_annotatepeaks_options ) -// include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' addParams( options: plot_macs2_qc_options ) // include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' addParams( options: macs2_consensus_options ) // //include { DESEQ2_QC } from '../modules/local/deseq2_qc' addParams( options: deseq2_qc_options, multiqc_label: 'star_salmon' ) // include { IGV } from '../modules/local/igv' addParams( options: [:] ) @@ -343,7 +342,7 @@ workflow CHIPSEQ { } .set { ch_control_bam_bai } - FILTER_BAM_BAMTOOLS + FILTER_BAM_BAMTOOLS .out .bam .join (FILTER_BAM_BAMTOOLS.out.bai, by: [0]) @@ -400,16 +399,16 @@ workflow CHIPSEQ { // ch_frip_score_header // ) - // PLOT_MACS2_QC ( - // MACS2_CALLPEAK.out.peak.collect{it[1]} - // ) + PLOT_MACS2_QC ( + MACS2_CALLPEAK.out.peak.collect{it[1]} + ) + ch_versions = ch_versions.mix(PLOT_MACS2_QC.out.versions) // HOMER_ANNOTATEPEAKS_MACS2 ( // MACS2_CALLPEAK.out.peak, // ch_fasta, // ch_gtf // ) - // // ch_software_versions = ch_software_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first().ifEmpty(null)) // ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions) // PLOT_HOMER_ANNOTATEPEAKS ( @@ -417,6 +416,7 @@ workflow CHIPSEQ { // ch_peak_annotation_header, // "_peaks.annotatePeaks.txt" // ) + // ch_versions = ch_versions.mix(PLOT_HOMER_ANNOTATEPEAKS.out.versions) // // Create channel: [ meta , [ peaks ] ] // // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] From 187631b646fe19767d959c55e0f1bc39966ad0cd Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 16:37:05 +0200 Subject: [PATCH 229/538] Adding hommer_annotatepeaks_macs2 module back --- workflows/chipseq.nf | 20 ++++++++++---------- 1 file changed, 10 insertions(+), 10 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 7fc556706..f09d219b9 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -133,12 +133,12 @@ macs2_callpeak_options.args += params.macs_fdr ? Utils.joinModuleArgs( macs2_callpeak_options.args += params.macs_pvalue ? Utils.joinModuleArgs(["--pvalue ${params.macs_pvalue}"]) : '' macs2_callpeak_options['publish_dir'] += "/$peakType" +def homer_annotatepeaks_macs2_options = modules['homer_annotatepeaks_macs2'] +homer_annotatepeaks_macs2_options['publish_dir'] += "/$peakType" + // def subread_featurecounts_options = modules['subread_featurecounts'] // subread_featurecounts_options['publish_dir'] += "/$peakType/consensus" -// def homer_annotatepeaks_macs2_options = modules['homer_annotatepeaks_macs2'] -// homer_annotatepeaks_macs2_options['publish_dir'] += "/$peakType" - // def homer_annotatepeaks_consensus_options = modules['homer_annotatepeaks_consensus'] // homer_annotatepeaks_consensus_options['publish_dir'] += "/$peakType/consensus" @@ -155,7 +155,7 @@ include { MACS2_CALLPEAK } from '../modules/nf-core/modules/macs2 // include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/modules/subread/featurecounts/main' addParams( options: subread_featurecounts_options ) include { CUSTOM_DUMPSOFTWAREVERSIONS } from '../modules/nf-core/modules/custom/dumpsoftwareversions/main' addParams( options: [publish_files : ['_versions.yml':'']] ) -// include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_macs2_options ) +include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_macs2_options ) // include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_consensus_options ) // @@ -404,12 +404,12 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(PLOT_MACS2_QC.out.versions) - // HOMER_ANNOTATEPEAKS_MACS2 ( - // MACS2_CALLPEAK.out.peak, - // ch_fasta, - // ch_gtf - // ) - // ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions) + HOMER_ANNOTATEPEAKS_MACS2 ( + MACS2_CALLPEAK.out.peak, + PREPARE_GENOME.out.fasta, + PREPARE_GENOME.out.gtf + ) + ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first()) // PLOT_HOMER_ANNOTATEPEAKS ( // HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, From beb78e6cd3d3fa99e6eb709534155d27b5a18bae Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 16:45:29 +0200 Subject: [PATCH 230/538] Adding plot_homer_annotatepeaks module back --- modules/local/plot_homer_annotatepeaks.nf | 5 +++-- workflows/chipseq.nf | 18 +++++++++--------- 2 files changed, 12 insertions(+), 11 deletions(-) diff --git a/modules/local/plot_homer_annotatepeaks.nf b/modules/local/plot_homer_annotatepeaks.nf index d6eb18ce7..0a2af6b59 100644 --- a/modules/local/plot_homer_annotatepeaks.nf +++ b/modules/local/plot_homer_annotatepeaks.nf @@ -1,5 +1,5 @@ // Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' +include { saveFiles; initOptions; getProcessName } from './functions' params.options = [:] options = initOptions(params.options) @@ -11,7 +11,7 @@ process PLOT_HOMER_ANNOTATEPEAKS { label 'process_medium' publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "${baseDir}/environment.yml" : null) //TODO Create mulled biocontainer @@ -24,6 +24,7 @@ process PLOT_HOMER_ANNOTATEPEAKS { path '*.txt', emit: txt path '*.pdf', emit: pdf path '*.tsv', emit: tsv + path "versions.yml", emit: versions script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ """ diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index f09d219b9..24d6babe2 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -64,8 +64,8 @@ def modules = params.modules.clone() def plot_macs2_qc_options = modules['plot_macs2_qc'] plot_macs2_qc_options.publish_dir += "/$peakType/qc" -// def plot_homer_annotatepeaks_options = modules['plot_homer_annotatepeaks'] -// plot_homer_annotatepeaks_options.publish_dir += "/$peakType/qc" +def plot_homer_annotatepeaks_options = modules['plot_homer_annotatepeaks'] +plot_homer_annotatepeaks_options.publish_dir += "/$peakType/qc" // def macs2_consensus_options = modules['macs2_consensus'] // macs2_consensus_options.publish_dir += "/$peakType/qc" @@ -77,7 +77,7 @@ plot_macs2_qc_options.publish_dir += "/$peakType/qc" include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_genomecov' addParams( options: modules['bedtools_genomecov'] ) include { FRIP_SCORE } from '../modules/local/frip_score' addParams( options: modules['frip_score'] ) include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' addParams( options: plot_macs2_qc_options ) -// include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' addParams( options: plot_homer_annotatepeaks_options ) +include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' addParams( options: plot_homer_annotatepeaks_options ) // include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' addParams( options: macs2_consensus_options ) // //include { DESEQ2_QC } from '../modules/local/deseq2_qc' addParams( options: deseq2_qc_options, multiqc_label: 'star_salmon' ) // include { IGV } from '../modules/local/igv' addParams( options: [:] ) @@ -411,12 +411,12 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first()) - // PLOT_HOMER_ANNOTATEPEAKS ( - // HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, - // ch_peak_annotation_header, - // "_peaks.annotatePeaks.txt" - // ) - // ch_versions = ch_versions.mix(PLOT_HOMER_ANNOTATEPEAKS.out.versions) + PLOT_HOMER_ANNOTATEPEAKS ( + HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, + ch_peak_annotation_header, + "_peaks.annotatePeaks.txt" + ) + ch_versions = ch_versions.mix(PLOT_HOMER_ANNOTATEPEAKS.out.versions.first()) // // Create channel: [ meta , [ peaks ] ] // // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] From 8ff4c28ebeb850913c2e551b542ec0a808d9dfab Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 18:12:24 +0200 Subject: [PATCH 231/538] Add macs2_consensus module back --- modules/local/macs2_consensus.nf | 11 +++--- workflows/chipseq.nf | 63 ++++++++++++++++---------------- 2 files changed, 38 insertions(+), 36 deletions(-) diff --git a/modules/local/macs2_consensus.nf b/modules/local/macs2_consensus.nf index da4319296..13f92ba02 100644 --- a/modules/local/macs2_consensus.nf +++ b/modules/local/macs2_consensus.nf @@ -20,15 +20,16 @@ process MACS2_CONSENSUS { tuple val(meta), path(peaks) output: - tuple val(meta), path("*.bed"), emit: bed - tuple val(meta), path("*.saf"), emit: saf - tuple val(meta), path("*.pdf"), emit: pdf - tuple val(meta), path("*.boolean.txt"), emit: boolean_txt + tuple val(meta), path("*.bed") , emit: bed + tuple val(meta), path("*.saf") , emit: saf + tuple val(meta), path("*.pdf") , emit: pdf + tuple val(meta), path("*.boolean.txt") , emit: boolean_txt tuple val(meta), path("*.intersect.txt"), emit: intersect_txt + path "versions.yml" , emit: versions script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ if (meta.multiple_groups || meta.replicates_exist) { - def software = getSoftwareName(task.process) + // def software = getSoftwareName(task.process) def prefix = options.suffix ? "${meta.id}${options.suffix}.consensus_peaks" : "${meta.id}.consensus_peaks" def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' def mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 24d6babe2..2f4d37dfb 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -67,8 +67,8 @@ plot_macs2_qc_options.publish_dir += "/$peakType/qc" def plot_homer_annotatepeaks_options = modules['plot_homer_annotatepeaks'] plot_homer_annotatepeaks_options.publish_dir += "/$peakType/qc" -// def macs2_consensus_options = modules['macs2_consensus'] -// macs2_consensus_options.publish_dir += "/$peakType/qc" +def macs2_consensus_options = modules['macs2_consensus'] +macs2_consensus_options.publish_dir += "/$peakType/qc" // def multiqc_options = modules['multiqc'] // multiqc_options.args += params.multiqc_title ? Utils.joinModuleArgs(["--title \"$params.multiqc_title\""]) : '' @@ -78,7 +78,7 @@ include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_ include { FRIP_SCORE } from '../modules/local/frip_score' addParams( options: modules['frip_score'] ) include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' addParams( options: plot_macs2_qc_options ) include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' addParams( options: plot_homer_annotatepeaks_options ) -// include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' addParams( options: macs2_consensus_options ) +include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' addParams( options: macs2_consensus_options ) // //include { DESEQ2_QC } from '../modules/local/deseq2_qc' addParams( options: deseq2_qc_options, multiqc_label: 'star_salmon' ) // include { IGV } from '../modules/local/igv' addParams( options: [:] ) // include { MULTIQC } from '../modules/local/multiqc' addParams( options: multiqc_options ) // TODO review @@ -416,34 +416,35 @@ workflow CHIPSEQ { ch_peak_annotation_header, "_peaks.annotatePeaks.txt" ) - ch_versions = ch_versions.mix(PLOT_HOMER_ANNOTATEPEAKS.out.versions.first()) - - // // Create channel: [ meta , [ peaks ] ] - // // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] - // MACS2_CALLPEAK - // .out - // .peak - // .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } - // .groupTuple() - // .map { - // antibody, groups, peaks -> - // [ - // antibody, - // groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, - // peaks - // ] } - // .map { - // antibody, groups, peaks -> - // def meta = [:] - // meta.id = antibody - // meta.multiple_groups = groups.size() > 1 - // meta.replicates_exist = groups.max { groups.value }.value > 1 - // [ meta, peaks ] } - // .set { ch_antibody_peaks } - - // MACS2_CONSENSUS ( - // ch_antibody_peaks - // ) + ch_versions = ch_versions.mix(PLOT_HOMER_ANNOTATEPEAKS.out.versions) + + // Create channel: [ meta , [ peaks ] ] + // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] + MACS2_CALLPEAK + .out + .peak + .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } + .groupTuple() + .map { + antibody, groups, peaks -> + [ + antibody, + groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, + peaks + ] } + .map { + antibody, groups, peaks -> + def meta = [:] + meta.id = antibody + meta.multiple_groups = groups.size() > 1 + meta.replicates_exist = groups.max { groups.value }.value > 1 + [ meta, peaks ] } + .set { ch_antibody_peaks } + + MACS2_CONSENSUS ( + ch_antibody_peaks + ) + ch_versions = ch_versions.mix(MACS2_CONSENSUS.out.versions) // HOMER_ANNOTATEPEAKS_CONSENSUS ( // MACS2_CONSENSUS.out.bed, From 84dc8a1e37eaeabd4da474be13af954e8be6fd10 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 18:25:11 +0200 Subject: [PATCH 232/538] Add subread_featurecounts module back --- workflows/chipseq.nf | 75 ++++++++++++++++++++++---------------------- 1 file changed, 37 insertions(+), 38 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 2f4d37dfb..f78e43b02 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -136,11 +136,11 @@ macs2_callpeak_options['publish_dir'] += "/$peakType" def homer_annotatepeaks_macs2_options = modules['homer_annotatepeaks_macs2'] homer_annotatepeaks_macs2_options['publish_dir'] += "/$peakType" -// def subread_featurecounts_options = modules['subread_featurecounts'] -// subread_featurecounts_options['publish_dir'] += "/$peakType/consensus" +def homer_annotatepeaks_consensus_options = modules['homer_annotatepeaks_consensus'] +homer_annotatepeaks_consensus_options['publish_dir'] += "/$peakType/consensus" -// def homer_annotatepeaks_consensus_options = modules['homer_annotatepeaks_consensus'] -// homer_annotatepeaks_consensus_options['publish_dir'] += "/$peakType/consensus" +def subread_featurecounts_options = modules['subread_featurecounts'] +subread_featurecounts_options['publish_dir'] += "/$peakType/consensus" include { PICARD_MERGESAMFILES } from '../modules/nf-core/modules/picard/mergesamfiles/main' addParams( options: modules['picard_mergesamfiles'] ) include { PICARD_COLLECTMULTIPLEMETRICS } from '../modules/nf-core/modules/picard/collectmultiplemetrics/main' addParams( options: modules['picard_collectmultiplemetrics'] ) @@ -152,11 +152,11 @@ include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/modules/deept include { DEEPTOOLS_PLOTHEATMAP } from '../modules/nf-core/modules/deeptools/plotheatmap/main' addParams( options: modules['deeptools_plotheatmap'] ) include { DEEPTOOLS_PLOTFINGERPRINT } from '../modules/nf-core/modules/deeptools/plotfingerprint/main' addParams( options: deeptools_plotfingerprint_options ) include { MACS2_CALLPEAK } from '../modules/nf-core/modules/macs2/callpeak/main' addParams( options: macs2_callpeak_options ) -// include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/modules/subread/featurecounts/main' addParams( options: subread_featurecounts_options ) +include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/modules/subread/featurecounts/main' addParams( options: subread_featurecounts_options ) include { CUSTOM_DUMPSOFTWAREVERSIONS } from '../modules/nf-core/modules/custom/dumpsoftwareversions/main' addParams( options: [publish_files : ['_versions.yml':'']] ) include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_macs2_options ) -// include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_consensus_options ) +include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_consensus_options ) // // SUBWORKFLOW: Consisting entirely of nf-core/modules @@ -446,39 +446,38 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(MACS2_CONSENSUS.out.versions) - // HOMER_ANNOTATEPEAKS_CONSENSUS ( - // MACS2_CONSENSUS.out.bed, - // ch_fasta, - // ch_gtf - // ) - // // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt - // // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt - - // // Create channel: [ val(meta), ip_bam ] - // MACS2_CONSENSUS - // .out - // .saf - // .map { meta, saf -> [ meta.id, meta, saf ] } - // .set { ch_ip_saf } - - // ch_ip_control_bam - // .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } - // .combine(ch_ip_saf) - // .map { - // it -> - // fmeta = it[1] - // fmeta['replicates_exist'] = it[4]['replicates_exist'] - // fmeta['multiple_groups'] = it[4]['multiple_groups'] - // [ fmeta, it[2], it[5] ] } - // .set { ch_ip_bam } - - // SUBREAD_FEATURECOUNTS ( - // ch_ip_bam - // ) - // // ch_software_versions = ch_software_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first().ifEmpty(null)) - // ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions) + HOMER_ANNOTATEPEAKS_CONSENSUS ( + MACS2_CONSENSUS.out.bed, + PREPARE_GENOME.out.fasta, + PREPARE_GENOME.out.gtf + ) + ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_CONSENSUS.out.versions) + // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt + // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt + + // Create channel: [ val(meta), ip_bam ] + MACS2_CONSENSUS + .out + .saf + .map { meta, saf -> [ meta.id, meta, saf ] } + .set { ch_ip_saf } + + ch_ip_control_bam + .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } + .combine(ch_ip_saf) + .map { + it -> + fmeta = it[1] + fmeta['replicates_exist'] = it[4]['replicates_exist'] + fmeta['multiple_groups'] = it[4]['multiple_groups'] + [ fmeta, it[2], it[5] ] } + .set { ch_ip_bam } + + SUBREAD_FEATURECOUNTS ( + ch_ip_bam + ) + ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first()) - // // // // DESEQ2_FEATURECOUNTS ( // // params.modules['deseq2_featurecounts'] // // ) From 33a7b79e4cc8a83b26ddf7ed655fb5718c259bb4 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 19:09:59 +0200 Subject: [PATCH 233/538] Add igv and multiqc back --- modules/local/igv.nf | 10 +-- modules/local/multiqc.nf | 2 +- workflows/chipseq.nf | 172 +++++++++++++++++++-------------------- 3 files changed, 89 insertions(+), 95 deletions(-) diff --git a/modules/local/igv.nf b/modules/local/igv.nf index 3ba90ba9c..ab74d50af 100644 --- a/modules/local/igv.nf +++ b/modules/local/igv.nf @@ -1,8 +1,7 @@ // Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' +include { saveFiles; getProcessName } from './functions' params.options = [:] -options = initOptions(params.options) /* * Create IGV session file @@ -10,7 +9,7 @@ options = initOptions(params.options) process IGV { publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), publish_id:'') } conda (params.enable_conda ? "conda-forge::python=3.8.3" : null) if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { @@ -30,8 +29,9 @@ process IGV { // path differential_peaks from ch_macs_consensus_deseq_comp_igv.collect().ifEmpty([]) output: - path "*files.txt", emit: txt - path "*.xml", emit: xml + path "*files.txt" , emit: txt + path "*.xml" , emit: xml + path "versions.yml", emit: versions script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ """ diff --git a/modules/local/multiqc.nf b/modules/local/multiqc.nf index 0390d1f79..734a413bd 100644 --- a/modules/local/multiqc.nf +++ b/modules/local/multiqc.nf @@ -31,8 +31,8 @@ process MULTIQC { path workflow_summary path ('fastqc/*') - path ('trimgalore/*') path ('trimgalore/fastqc/*') + path ('trimgalore/*') path ('alignment/library/*') path ('alignment/library/*') diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index f78e43b02..54669ea4f 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -70,20 +70,20 @@ plot_homer_annotatepeaks_options.publish_dir += "/$peakType/qc" def macs2_consensus_options = modules['macs2_consensus'] macs2_consensus_options.publish_dir += "/$peakType/qc" -// def multiqc_options = modules['multiqc'] -// multiqc_options.args += params.multiqc_title ? Utils.joinModuleArgs(["--title \"$params.multiqc_title\""]) : '' -// multiqc_options.publish_dir += "/$peakType" +def multiqc_options = modules['multiqc'] +multiqc_options.args += params.multiqc_title ? Utils.joinModuleArgs(["--title \"$params.multiqc_title\""]) : '' +multiqc_options.publish_dir += "/$peakType" include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_genomecov' addParams( options: modules['bedtools_genomecov'] ) include { FRIP_SCORE } from '../modules/local/frip_score' addParams( options: modules['frip_score'] ) include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' addParams( options: plot_macs2_qc_options ) include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' addParams( options: plot_homer_annotatepeaks_options ) include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' addParams( options: macs2_consensus_options ) -// //include { DESEQ2_QC } from '../modules/local/deseq2_qc' addParams( options: deseq2_qc_options, multiqc_label: 'star_salmon' ) -// include { IGV } from '../modules/local/igv' addParams( options: [:] ) -// include { MULTIQC } from '../modules/local/multiqc' addParams( options: multiqc_options ) // TODO review -// include { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS } from '../modules/local/multiqc_custom_phantompeakqualtools' addParams( options: modules['multiqc_custom_phantompeakqualtools'] ) -// include { MULTIQC_CUSTOM_PEAKS } from '../modules/local/multiqc_custom_peaks' addParams( options: modules['multiqc_custom_peaks'] ) +//include { DESEQ2_QC } from '../modules/local/deseq2_qc' addParams( options: deseq2_qc_options, multiqc_label: 'star_salmon' ) +include { IGV } from '../modules/local/igv' addParams( options: [:] ) +include { MULTIQC } from '../modules/local/multiqc' addParams( options: multiqc_options ) // TODO review +include { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS } from '../modules/local/multiqc_custom_phantompeakqualtools' addParams( options: modules['multiqc_custom_phantompeakqualtools'] ) +include { MULTIQC_CUSTOM_PEAKS } from '../modules/local/multiqc_custom_peaks' addParams( options: modules['multiqc_custom_peaks'] ) // // SUBWORKFLOW: Consisting of a mix of local and nf-core/modules @@ -286,12 +286,12 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions.first()) - // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( - // PHANTOMPEAKQUALTOOLS.out.spp.join(PHANTOMPEAKQUALTOOLS.out.rdata, by: [0]), - // ch_spp_nsc_header, - // ch_spp_rsc_header, - // ch_spp_correlation_header - // ) + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( + PHANTOMPEAKQUALTOOLS.out.spp.join(PHANTOMPEAKQUALTOOLS.out.rdata, by: [0]), + ch_spp_nsc_header, + ch_spp_rsc_header, + ch_spp_correlation_header + ) // // MODULE: Coverage tracks @@ -388,16 +388,16 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(FRIP_SCORE.out.versions.first()) - // ch_ip_peak - // .join(FRIP_SCORE.out.txt, by: [0]) - // .map { it -> [ it[0], it[2], it[3] ] } - // .set { ch_ip_peak_frip } + ch_ip_peak + .join(FRIP_SCORE.out.txt, by: [0]) + .map { it -> [ it[0], it[2], it[3] ] } + .set { ch_ip_peak_frip } - // MULTIQC_CUSTOM_PEAKS ( - // ch_ip_peak_frip, - // ch_peak_count_header, - // ch_frip_score_header - // ) + MULTIQC_CUSTOM_PEAKS ( + ch_ip_peak_frip, + ch_peak_count_header, + ch_frip_score_header + ) PLOT_MACS2_QC ( MACS2_CALLPEAK.out.peak.collect{it[1]} @@ -486,18 +486,19 @@ workflow CHIPSEQ { } - // // - // // Create IGV session - // // - // IGV ( - // ch_fasta, - // UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), - // MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), - // MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), - // params.modules['ucsc_bedgraphtobigwig'], - // params.modules['macs2_callpeak'], - // params.modules['macs2_consensus'] - // ) + // + // Create IGV session + // + IGV ( + PREPARE_GENOME.out.fasta, + UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), + MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), + MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), + params.modules['ucsc_bedgraphtobigwig'], + params.modules['macs2_callpeak'], + params.modules['macs2_consensus'] + ) + ch_versions = ch_versions.mix(IGV.out.versions) // // MODULE: Pipeline reporting @@ -506,60 +507,53 @@ workflow CHIPSEQ { ch_versions.unique().collectFile(name: 'collated_versions.yml') ) - // // - // // MODULE: MultiQC - // // - // // ch_multiqc_files = Channel.empty() - // // ch_multiqc_files = ch_multiqc_files.mix(Channel.from(ch_multiqc_config)) - // // ch_multiqc_files = ch_multiqc_files.mix(ch_multiqc_custom_config.collect().ifEmpty([])) - // // ch_multiqc_files = ch_multiqc_files.mix(ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml')) - // // ch_multiqc_files = ch_multiqc_files.mix(GET_SOFTWARE_VERSIONS.out.yaml.collect()) - // // ch_multiqc_files = ch_multiqc_files.mix(FASTQC.out.zip.collect{it[1]}.ifEmpty([])) - - // if (!params.skip_multiqc) { - // workflow_summary = WorkflowChipseq.paramsSummaryMultiqc(workflow, summary_params) - // ch_workflow_summary = Channel.value(workflow_summary) - - // MULTIQC ( - // ch_multiqc_config, - // ch_multiqc_custom_config.collect().ifEmpty([]), - // CUSTOM_DUMPSOFTWAREVERSIONS.out.mqc_yml.collect(), - // ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml'), - - // FASTQC_TRIMGALORE.out.fastqc_zip.collect{it[1]}.ifEmpty([]), - // FASTQC_TRIMGALORE.out.trim_log.collect{it[1]}.ifEmpty([]), - // FASTQC_TRIMGALORE.out.trim_zip.collect{it[1]}.ifEmpty([]), - - // MAP_BWA_MEM.out.stats.collect{it[1]}, - // MAP_BWA_MEM.out.flagstat.collect{it[1]}, - // MAP_BWA_MEM.out.idxstats.collect{it[1]}, - - // MARK_DUPLICATES_PICARD.out.stats.collect{it[1]}.ifEmpty([]), - // MARK_DUPLICATES_PICARD.out.flagstat.collect{it[1]}.ifEmpty([]), - // MARK_DUPLICATES_PICARD.out.idxstats.collect{it[1]}.ifEmpty([]), - // MARK_DUPLICATES_PICARD.out.metrics.collect{it[1]}.ifEmpty([]), - - // BAM_CLEAN.out.stats.collect{it[1]}.ifEmpty([]), - // BAM_CLEAN.out.flagstat.collect{it[1]}.ifEmpty([]), - // BAM_CLEAN.out.idxstats.collect{it[1]}.ifEmpty([]), - // PICARD_COLLECTMULTIPLEMETRICS.out.metrics.collect{it[1]}.ifEmpty([]), - - // PRESEQ_LCEXTRAP.out.ccurve.collect{it[1]}.ifEmpty([]), - // DEEPTOOLS_PLOTPROFILE.out.table.collect{it[1]}.ifEmpty([]), - // DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect{it[1]}.ifEmpty([]), - // PHANTOMPEAKQUALTOOLS.out.spp.collect{it[1]}.ifEmpty([]), - // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.nsc.collect{it[1]}.ifEmpty([]), - // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.rsc.collect{it[1]}.ifEmpty([]), - // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.correlation.collect{it[1]}.ifEmpty([]), - - // MULTIQC_CUSTOM_PEAKS.out.count.collect{it[1]}.ifEmpty([]), - // MULTIQC_CUSTOM_PEAKS.out.frip.collect{it[1]}.ifEmpty([]), - // PLOT_HOMER_ANNOTATEPEAKS.out.tsv.collect().ifEmpty([]), - // SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), - // // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) - // ) - // multiqc_report = MULTIQC.out.report.toList() - // } + // + // MODULE: MultiQC + // + if (!params.skip_multiqc) { + workflow_summary = WorkflowChipseq.paramsSummaryMultiqc(workflow, summary_params) + ch_workflow_summary = Channel.value(workflow_summary) + + MULTIQC ( + ch_multiqc_config, + ch_multiqc_custom_config.collect().ifEmpty([]), + CUSTOM_DUMPSOFTWAREVERSIONS.out.mqc_yml.collect(), + ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml'), + + FASTQC_TRIMGALORE.out.fastqc_zip.collect{it[1]}.ifEmpty([]), + FASTQC_TRIMGALORE.out.trim_zip.collect{it[1]}.ifEmpty([]), + FASTQC_TRIMGALORE.out.trim_log.collect{it[1]}.ifEmpty([]), + + ALIGN_BWA_MEM.out.stats.collect{it[1]}, + ALIGN_BWA_MEM.out.flagstat.collect{it[1]}, + ALIGN_BWA_MEM.out.idxstats.collect{it[1]}, + + MARK_DUPLICATES_PICARD.out.stats.collect{it[1]}.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.flagstat.collect{it[1]}.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.idxstats.collect{it[1]}.ifEmpty([]), + MARK_DUPLICATES_PICARD.out.metrics.collect{it[1]}.ifEmpty([]), + + FILTER_BAM_BAMTOOLS.out.stats.collect{it[1]}.ifEmpty([]), + FILTER_BAM_BAMTOOLS.out.flagstat.collect{it[1]}.ifEmpty([]), + FILTER_BAM_BAMTOOLS.out.idxstats.collect{it[1]}.ifEmpty([]), + PICARD_COLLECTMULTIPLEMETRICS.out.metrics.collect{it[1]}.ifEmpty([]), + + PRESEQ_LCEXTRAP.out.ccurve.collect{it[1]}.ifEmpty([]), + DEEPTOOLS_PLOTPROFILE.out.table.collect{it[1]}.ifEmpty([]), + DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect{it[1]}.ifEmpty([]), + PHANTOMPEAKQUALTOOLS.out.spp.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.nsc.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.rsc.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.correlation.collect{it[1]}.ifEmpty([]), + + MULTIQC_CUSTOM_PEAKS.out.count.collect{it[1]}.ifEmpty([]), + MULTIQC_CUSTOM_PEAKS.out.frip.collect{it[1]}.ifEmpty([]), + PLOT_HOMER_ANNOTATEPEAKS.out.tsv.collect().ifEmpty([]), + SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), + // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) + ) + multiqc_report = MULTIQC.out.report.toList() + } } /* From d59a2ba9a73cc983044c1aaaa327f50f704b8a63 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 19:13:06 +0200 Subject: [PATCH 234/538] Finish cleaning of multiqc module --- modules/local/multiqc.nf | 6 +----- 1 file changed, 1 insertion(+), 5 deletions(-) diff --git a/modules/local/multiqc.nf b/modules/local/multiqc.nf index 734a413bd..70a141474 100644 --- a/modules/local/multiqc.nf +++ b/modules/local/multiqc.nf @@ -66,14 +66,10 @@ process MULTIQC { output: path "*multiqc_report.html", emit: report path "*_data" , emit: data + path "*_plots" , optional:true, emit: plots path "versions.yml" , emit: versions - // TODO add the line below: - // path "*_plots" , optional:true, emit: plots script: - // def software = getSoftwareName(task.process) - // def rtitle = custom_runName ? "--title \"$custom_runName\"" : '' - // def rfilename = custom_runName ? "--filename " + custom_runName.replaceAll('\\W','_').replaceAll('_+','_') + "_multiqc_report" : '' def custom_config = params.multiqc_config ? "--config $mqc_custom_config" : '' """ multiqc \\ From 4fbafd53dde65edb0f24e1e98c7e22ea6ceaa5b3 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Oct 2021 19:14:08 +0200 Subject: [PATCH 235/538] Some cleaning --- nextflow.config | 2 +- workflows/chipseq.nf | 2 +- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/nextflow.config b/nextflow.config index 86f36760b..fdeefcc0a 100644 --- a/nextflow.config +++ b/nextflow.config @@ -82,7 +82,6 @@ params { schema_ignore_params = 'genomes,modules' enable_conda = false singularity_pull_docker_container = false - // name = false // TODO remove parameter // Config options custom_config_version = 'master' @@ -104,6 +103,7 @@ params { // Container slug. Stable releases should specify release tag! // Developmental code should specify :dev // TODO some process will be run by default using this image by now, the individual process container/env should be added +// when the corresponding mulled containers are created and added to the processes process.container = 'nfcore/chipseq:dev' // Load base.config by default for all pipelines diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 54669ea4f..6088a7674 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -81,7 +81,7 @@ include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_home include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' addParams( options: macs2_consensus_options ) //include { DESEQ2_QC } from '../modules/local/deseq2_qc' addParams( options: deseq2_qc_options, multiqc_label: 'star_salmon' ) include { IGV } from '../modules/local/igv' addParams( options: [:] ) -include { MULTIQC } from '../modules/local/multiqc' addParams( options: multiqc_options ) // TODO review +include { MULTIQC } from '../modules/local/multiqc' addParams( options: multiqc_options ) include { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS } from '../modules/local/multiqc_custom_phantompeakqualtools' addParams( options: modules['multiqc_custom_phantompeakqualtools'] ) include { MULTIQC_CUSTOM_PEAKS } from '../modules/local/multiqc_custom_peaks' addParams( options: modules['multiqc_custom_peaks'] ) From a781ddf464e160274e52060bf389ab2edabee244 Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Tue, 26 Oct 2021 22:49:51 +0200 Subject: [PATCH 236/538] Update workflows/chipseq.nf Co-authored-by: Harshil Patel --- workflows/chipseq.nf | 1 - 1 file changed, 1 deletion(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 6088a7674..1a9e4e7df 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -260,7 +260,6 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(FILTER_BAM_BAMTOOLS.out.versions.first().ifEmpty(null)) - // // MODULE: Post alignment QC // From 3bdec28f4fe60b927fefe035e7e0b1b3fed1e51c Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Tue, 26 Oct 2021 22:50:19 +0200 Subject: [PATCH 237/538] Update modules/local/macs2_consensus.nf Co-authored-by: Harshil Patel --- modules/local/macs2_consensus.nf | 1 - 1 file changed, 1 deletion(-) diff --git a/modules/local/macs2_consensus.nf b/modules/local/macs2_consensus.nf index 13f92ba02..5c6615d32 100644 --- a/modules/local/macs2_consensus.nf +++ b/modules/local/macs2_consensus.nf @@ -29,7 +29,6 @@ process MACS2_CONSENSUS { script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ if (meta.multiple_groups || meta.replicates_exist) { - // def software = getSoftwareName(task.process) def prefix = options.suffix ? "${meta.id}${options.suffix}.consensus_peaks" : "${meta.id}.consensus_peaks" def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' def mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') From 66d7390b5bc4a5859a4824f05df6fd26dffc01d8 Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Tue, 26 Oct 2021 23:32:28 +0200 Subject: [PATCH 238/538] Update modules/local/igv.nf Co-authored-by: Harshil Patel --- modules/local/igv.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/modules/local/igv.nf b/modules/local/igv.nf index ab74d50af..29798880a 100644 --- a/modules/local/igv.nf +++ b/modules/local/igv.nf @@ -9,7 +9,7 @@ params.options = [:] process IGV { publishDir "${params.outdir}", mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), publish_id:'') } + saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "conda-forge::python=3.8.3" : null) if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { From 69fe49ffb7ef615a4eb54d4245db7754a268e8d1 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 27 Oct 2021 15:37:41 +0200 Subject: [PATCH 239/538] Add environments for plot_hommer_annotatepeaks --- modules/local/plot_homer_annotatepeaks.nf | 7 ++++++- 1 file changed, 6 insertions(+), 1 deletion(-) diff --git a/modules/local/plot_homer_annotatepeaks.nf b/modules/local/plot_homer_annotatepeaks.nf index 0a2af6b59..2cd9b654e 100644 --- a/modules/local/plot_homer_annotatepeaks.nf +++ b/modules/local/plot_homer_annotatepeaks.nf @@ -13,7 +13,12 @@ process PLOT_HOMER_ANNOTATEPEAKS { mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:[:], publish_by_meta:[]) } - conda (params.enable_conda ? "${baseDir}/environment.yml" : null) //TODO Create mulled biocontainer + conda (params.enable_conda ? "conda-forge::r-base=4.0.3 conda-forge::r-reshape2=1.4.4 conda-forge::r-optparse=1.6.6 conda-forge::r-ggplot2=3.3.3 conda-forge::r-scales=1.1.1 conda-forge::r-viridis=0.5.1 conda-forge::r-tidyverse=1.3.0 bioconda::bioconductor-biostrings=2.58.0 bioconda::bioconductor-complexheatmap=2.6.2" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://depot.galaxyproject.org/singularity/mulled-v2-ad9dd5f398966bf899ae05f8e7c54d0fb10cdfa7:05678da05b8e5a7a5130e90a9f9a6c585b965afa-0" + } else { + container "quay.io/biocontainers/mulled-v2-ad9dd5f398966bf899ae05f8e7c54d0fb10cdfa7:05678da05b8e5a7a5130e90a9f9a6c585b965afa-0" + } input: path annos From 082d07e670cc6096a3f9c418adc6a78bf42c2b85 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 27 Oct 2021 15:45:02 +0200 Subject: [PATCH 240/538] Add environments for plot_macs2_qc --- modules/local/plot_macs2_qc.nf | 7 ++++++- 1 file changed, 6 insertions(+), 1 deletion(-) diff --git a/modules/local/plot_macs2_qc.nf b/modules/local/plot_macs2_qc.nf index e83a4f8a7..3080a46e8 100644 --- a/modules/local/plot_macs2_qc.nf +++ b/modules/local/plot_macs2_qc.nf @@ -13,7 +13,12 @@ process PLOT_MACS2_QC { mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:[:], publish_by_meta:[]) } - conda (params.enable_conda ? "${baseDir}/environment.yml" : null) //TODO Create updated mulled container + conda (params.enable_conda ? "conda-forge::r-base=4.0.3 conda-forge::r-reshape2=1.4.4 conda-forge::r-optparse=1.6.6 conda-forge::r-ggplot2=3.3.3 conda-forge::r-scales=1.1.1 conda-forge::r-viridis=0.5.1 conda-forge::r-tidyverse=1.3.0 bioconda::bioconductor-biostrings=2.58.0 bioconda::bioconductor-complexheatmap=2.6.2" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://depot.galaxyproject.org/singularity/mulled-v2-ad9dd5f398966bf899ae05f8e7c54d0fb10cdfa7:05678da05b8e5a7a5130e90a9f9a6c585b965afa-0" + } else { + container "quay.io/biocontainers/mulled-v2-ad9dd5f398966bf899ae05f8e7c54d0fb10cdfa7:05678da05b8e5a7a5130e90a9f9a6c585b965afa-0" + } input: path peaks From ff78d7c571ddb3c530735787ce47ecdb0f6c99c9 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 27 Oct 2021 17:13:03 +0200 Subject: [PATCH 241/538] Mulled container working, no version update --- modules/local/frip_score.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/modules/local/frip_score.nf b/modules/local/frip_score.nf index 7294d08af..ad9123b72 100644 --- a/modules/local/frip_score.nf +++ b/modules/local/frip_score.nf @@ -11,7 +11,7 @@ process FRIP_SCORE { mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:meta, publish_by_meta:['id']) } - conda (params.enable_conda ? "bioconda::bedtools=2.30.0 bioconda::samtools=1.9" : null) //TODO Create updated mulled container + conda (params.enable_conda ? "bioconda::bedtools=2.30.0 bioconda::samtools=1.9" : null) if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { container "https://depot.galaxyproject.org/singularity/mulled-v2-8186960447c5cb2faa697666dc1e6d919ad23f3e:2200fd433290bb814a952b2fd7cc8013499de840-0" } else { From 40b8af7d1a8842ef9b58cfa005f8f2adea61abdc Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 27 Oct 2021 17:22:57 +0200 Subject: [PATCH 242/538] Mulled container working, no version update --- modules/local/bam_filter.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/modules/local/bam_filter.nf b/modules/local/bam_filter.nf index 1c7f1b807..b6a17db8e 100644 --- a/modules/local/bam_filter.nf +++ b/modules/local/bam_filter.nf @@ -14,7 +14,7 @@ process BAM_FILTER { mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:meta, publish_by_meta:['id']) } - conda (params.enable_conda ? "bioconda::bamtools=2.4.0 bioconda::samtools=1.4.1" : null) //TODO Create updated mulled container + conda (params.enable_conda ? "bioconda::bamtools=2.4.0 bioconda::samtools=1.4.1" : null) if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { container "https://depot.galaxyproject.org/singularity/mulled-v2-0560a8046fc82aa4338588eca29ff18edab2c5aa:fc33176431a4b9ef3213640937e641d731db04f1-0" } else { From 822cafee6e03121fd743793efcb4cd85e121f609 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 27 Oct 2021 17:23:28 +0200 Subject: [PATCH 243/538] Delete multiqc comment --- modules/local/multiqc.nf | 7 ------- 1 file changed, 7 deletions(-) diff --git a/modules/local/multiqc.nf b/modules/local/multiqc.nf index 70a141474..319549e60 100644 --- a/modules/local/multiqc.nf +++ b/modules/local/multiqc.nf @@ -4,13 +4,6 @@ include { initOptions; saveFiles; getSoftwareName; getProcessName } from './func params.options = [:] options = initOptions(params.options) -// Has the run name been specified by the user? -// this has the bonus effect of catching both -name and --name -// custom_runName = params.name // TODO remove -// if (!(workflow.runName ==~ /[a-z]+_[a-z]+/)) { -// custom_runName = workflow.runName -// } - process MULTIQC { label 'process_medium' publishDir "${params.outdir}", From ef1889326b06019b0aee4f75a11652ac82d09105 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 3 Nov 2021 09:27:00 +0100 Subject: [PATCH 244/538] Add mulled container to bam_remove_orphans --- modules/local/bam_remove_orphans.nf | 13 ++++++------- 1 file changed, 6 insertions(+), 7 deletions(-) diff --git a/modules/local/bam_remove_orphans.nf b/modules/local/bam_remove_orphans.nf index 16b90e924..5c6ce5086 100644 --- a/modules/local/bam_remove_orphans.nf +++ b/modules/local/bam_remove_orphans.nf @@ -14,13 +14,12 @@ process BAM_REMOVE_ORPHANS { mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:meta, publish_by_meta:['id']) } - conda (params.enable_conda ? "${baseDir}/environment.yml" : null) - // conda (params.enable_conda ? "conda-forge::python=3.7.6 bioconda::samtools=1.9" : null) //TODO Create updated mulled container - // if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - // container "https://depot.galaxyproject.org/singularity/mulled-v2-1a35167f7a491c7086c13835aaa74b39f1f43979:b8bbb1dc1cb75db128173603ca7a050729cdc526-0" - // } else { - // container "quay.io/biocontainers/mulled-v2-1a35167f7a491c7086c13835aaa74b39f1f43979:b8bbb1dc1cb75db128173603ca7a050729cdc526-0" - // } // TODO: Needs pysam library that is not in the mulled container + conda (params.enable_conda ? "bioconda::pysam=0.16.0.1 bioconda::samtools=1.13" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://depot.galaxyproject.org/singularity/mulled-v2-57736af1eb98c01010848572c9fec9fff6ffaafd:980645707aa512b63b32c44c35888ac1dab126dd-0" + } else { + container "quay.io/biocontainers/mulled-v2-57736af1eb98c01010848572c9fec9fff6ffaafd:980645707aa512b63b32c44c35888ac1dab126dd-0" + } input: tuple val(meta), path(bam) From 312cf6f40cc1d5f6438f502ba59e7b0ce0dfdc28 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 9 Nov 2021 22:19:20 +0100 Subject: [PATCH 245/538] Add mulled container to macs2_consensus --- modules/local/macs2_consensus.nf | 8 +++++++- 1 file changed, 7 insertions(+), 1 deletion(-) diff --git a/modules/local/macs2_consensus.nf b/modules/local/macs2_consensus.nf index 5c6615d32..dfd05d4bb 100644 --- a/modules/local/macs2_consensus.nf +++ b/modules/local/macs2_consensus.nf @@ -14,7 +14,13 @@ process MACS2_CONSENSUS { mode: params.publish_dir_mode, saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } - conda (params.enable_conda ? "${baseDir}/environment.yml" : null) + conda (params.enable_conda ? "conda-forge::biopython conda-forge::r-optparse=1.7.1 conda-forge::r-upsetr=1.4.0 bioconda::bedtools=2.30.0" : null) + if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { + container "https://depot.galaxyproject.org/singularity/mulled-v2-2f48cc59b03027e31ead6d383fe1b8057785dd24:5d182f583f4696f4c4d9f3be93052811b383341f-0" + } else { + // container "quay.io/biocontainers/mulled-v2-dc9ae2a680e9de06c4c555847fbdb8d178f465e6:5e559b41071eb9b24eb25e3a763a75e557120b69-0" + container "quay.io/biocontainers/mulled-v2-2f48cc59b03027e31ead6d383fe1b8057785dd24:5d182f583f4696f4c4d9f3be93052811b383341f-0" + } input: tuple val(meta), path(peaks) From 511ef297be8d8d0f50ca4fde817b05632b32ca0a Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 9 Nov 2021 22:20:29 +0100 Subject: [PATCH 246/538] Fix versions reporting --- modules/local/plot_macs2_qc.nf | 1 - 1 file changed, 1 deletion(-) diff --git a/modules/local/plot_macs2_qc.nf b/modules/local/plot_macs2_qc.nf index 3080a46e8..3f5590481 100644 --- a/modules/local/plot_macs2_qc.nf +++ b/modules/local/plot_macs2_qc.nf @@ -38,7 +38,6 @@ process PLOT_MACS2_QC { cat <<-END_VERSIONS > versions.yml ${getProcessName(task.process)}: - python: \$(python --version | sed 's/Python //g') r-base: \$(echo \$(R --version 2>&1) | sed 's/^.*R version //; s/ .*\$//') END_VERSIONS """ From 0b29cb9561d72ab09c7346298ea65c38bf9d96d5 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 9 Nov 2021 22:29:39 +0100 Subject: [PATCH 247/538] Dump version after each module execution and not at the end --- subworkflows/nf-core/align_bwa_mem.nf | 12 +++++++++--- subworkflows/nf-core/bam_sort_samtools.nf | 9 +++++---- subworkflows/nf-core/bam_stats_samtools.nf | 13 +++++++------ 3 files changed, 21 insertions(+), 13 deletions(-) diff --git a/subworkflows/nf-core/align_bwa_mem.nf b/subworkflows/nf-core/align_bwa_mem.nf index 98c73149e..3d1c8a325 100644 --- a/subworkflows/nf-core/align_bwa_mem.nf +++ b/subworkflows/nf-core/align_bwa_mem.nf @@ -19,11 +19,17 @@ workflow ALIGN_BWA_MEM { ch_versions = Channel.empty() + // + // Map reads with BWA + // BWA_MEM(reads, index) - BAM_SORT_SAMTOOLS(BWA_MEM.out.bam) + ch_versions = ch_versions.mix(BWA_MEM.out.versions.first()) - ch_versions = ch_versions.mix(BWA_MEM.out.versions.first(), - BAM_SORT_SAMTOOLS.out.versions) + // + // Sort, index BAM file and run samtools stats, flagstat and idxstats + // + BAM_SORT_SAMTOOLS(BWA_MEM.out.bam) + ch_versions = ch_versions.mix(BAM_SORT_SAMTOOLS.out.versions.first()) emit: bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] diff --git a/subworkflows/nf-core/bam_sort_samtools.nf b/subworkflows/nf-core/bam_sort_samtools.nf index e7652259a..53148682a 100644 --- a/subworkflows/nf-core/bam_sort_samtools.nf +++ b/subworkflows/nf-core/bam_sort_samtools.nf @@ -19,12 +19,13 @@ workflow BAM_SORT_SAMTOOLS { ch_versions = Channel.empty() SAMTOOLS_SORT(ch_bam) + ch_versions = ch_versions.mix(SAMTOOLS_SORT.out.versions.first()) + SAMTOOLS_INDEX(SAMTOOLS_SORT.out.bam) - BAM_STATS_SAMTOOLS(SAMTOOLS_SORT.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0])) + ch_versions = ch_versions.mix(SAMTOOLS_INDEX.out.versions.first()) - ch_versions = ch_versions.mix(SAMTOOLS_SORT.out.versions.first(), - SAMTOOLS_INDEX.out.versions.first(), - BAM_STATS_SAMTOOLS.out.versions) + BAM_STATS_SAMTOOLS(SAMTOOLS_SORT.out.bam.join(SAMTOOLS_INDEX.out.bai, by: [0])) + ch_versions = ch_versions.mix(BAM_STATS_SAMTOOLS.out.versions) emit: bam = SAMTOOLS_SORT.out.bam // channel: [ val(meta), [ bam ] ] diff --git a/subworkflows/nf-core/bam_stats_samtools.nf b/subworkflows/nf-core/bam_stats_samtools.nf index 013ffac9e..5307c239c 100644 --- a/subworkflows/nf-core/bam_stats_samtools.nf +++ b/subworkflows/nf-core/bam_stats_samtools.nf @@ -16,13 +16,14 @@ workflow BAM_STATS_SAMTOOLS { ch_versions = Channel.empty() - SAMTOOLS_STATS(ch_bam_bai) - SAMTOOLS_FLAGSTAT(ch_bam_bai) - SAMTOOLS_IDXSTATS(ch_bam_bai) + SAMTOOLS_STATS ( ch_bam_bai ) + ch_versions = ch_versions.mix(SAMTOOLS_STATS.out.versions.first()) - ch_versions = ch_versions.mix(SAMTOOLS_STATS.out.versions.first(), - SAMTOOLS_FLAGSTAT.out.versions.first(), - SAMTOOLS_IDXSTATS.out.versions.first()) + SAMTOOLS_FLAGSTAT ( ch_bam_bai ) + ch_versions = ch_versions.mix(SAMTOOLS_FLAGSTAT.out.versions.first()) + + SAMTOOLS_IDXSTATS ( ch_bam_bai ) + ch_versions = ch_versions.mix(SAMTOOLS_IDXSTATS.out.versions.first()) emit: stats = SAMTOOLS_STATS.out.stats // channel: [ val(meta), [ stats ] ] From a26726763b001290f9161f951db10445a50fd86a Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 9 Nov 2021 22:32:14 +0100 Subject: [PATCH 248/538] Get rid of the single container in nextflow.config --- .nf-core.yml | 1 - nextflow.config | 9 --------- 2 files changed, 10 deletions(-) diff --git a/.nf-core.yml b/.nf-core.yml index c8445e750..daf3ed014 100644 --- a/.nf-core.yml +++ b/.nf-core.yml @@ -5,7 +5,6 @@ lint: - assets/email_template.txt - lib/NfcoreTemplate.groovy - assets/multiqc_config.yaml - actions_ci: False #get rid of the error "CI is not building the correct docker image. Should be: docker build..." files_exist: - bin/scrape_software_versions.py - modules/local/get_software_versions.nf diff --git a/nextflow.config b/nextflow.config index fdeefcc0a..58be034c9 100644 --- a/nextflow.config +++ b/nextflow.config @@ -100,12 +100,6 @@ params { } -// Container slug. Stable releases should specify release tag! -// Developmental code should specify :dev -// TODO some process will be run by default using this image by now, the individual process container/env should be added -// when the corresponding mulled containers are created and added to the processes -process.container = 'nfcore/chipseq:dev' - // Load base.config by default for all pipelines includeConfig 'conf/base.config' @@ -177,9 +171,6 @@ profiles { test_full { includeConfig 'conf/test_full.config' } } -// Increase time available to build conda environment -conda { createTimeout = "60 min" } - // Export these variables to prevent local Python/R libraries from conflicting with those in the container env { PYTHONNOUSERSITE = 1 From a7e43b8ddea4ac6a1026ee40c8ef2e5a46ca75f4 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 9 Nov 2021 22:32:33 +0100 Subject: [PATCH 249/538] Fix nextflow_schema --- nextflow_schema.json | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index f7198db55..b31317e2e 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -28,7 +28,7 @@ "type": "integer", "description": "Estimated fragment size used to extend single-end reads.", "fa_icon": "fas fa-chart-area", - "default": "200" + "default": 200 }, "seq_center": { "type": "string", @@ -588,4 +588,4 @@ "$ref": "#/definitions/generic_options" } ] -} +} \ No newline at end of file From 679f0137db336286ab4871e19f97c288d5c03e1a Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Thu, 11 Nov 2021 13:39:48 +0100 Subject: [PATCH 250/538] Update modules/local/macs2_consensus.nf Co-authored-by: Harshil Patel --- modules/local/macs2_consensus.nf | 1 - 1 file changed, 1 deletion(-) diff --git a/modules/local/macs2_consensus.nf b/modules/local/macs2_consensus.nf index dfd05d4bb..53248d5f9 100644 --- a/modules/local/macs2_consensus.nf +++ b/modules/local/macs2_consensus.nf @@ -18,7 +18,6 @@ process MACS2_CONSENSUS { if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { container "https://depot.galaxyproject.org/singularity/mulled-v2-2f48cc59b03027e31ead6d383fe1b8057785dd24:5d182f583f4696f4c4d9f3be93052811b383341f-0" } else { - // container "quay.io/biocontainers/mulled-v2-dc9ae2a680e9de06c4c555847fbdb8d178f465e6:5e559b41071eb9b24eb25e3a763a75e557120b69-0" container "quay.io/biocontainers/mulled-v2-2f48cc59b03027e31ead6d383fe1b8057785dd24:5d182f583f4696f4c4d9f3be93052811b383341f-0" } From 41ce4ecddffc898f59305d91dab438a822df333f Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 2 Dec 2021 22:12:03 +0100 Subject: [PATCH 251/538] Update nf-core modules --- modules.json | 54 +++++------ .../nf-core/modules/bwa/index/functions.nf | 78 --------------- modules/nf-core/modules/bwa/index/main.nf | 28 ++---- modules/nf-core/modules/bwa/mem/functions.nf | 78 --------------- modules/nf-core/modules/bwa/mem/main.nf | 29 ++---- .../custom/dumpsoftwareversions/functions.nf | 78 --------------- .../custom/dumpsoftwareversions/main.nf | 95 +------------------ .../custom/dumpsoftwareversions/meta.yml | 1 + .../templates/dumpsoftwareversions.py | 89 +++++++++++++++++ .../deeptools/computematrix/functions.nf | 78 --------------- .../modules/deeptools/computematrix/main.nf | 26 ++--- .../deeptools/plotfingerprint/functions.nf | 78 --------------- .../modules/deeptools/plotfingerprint/main.nf | 26 ++--- .../deeptools/plotheatmap/functions.nf | 78 --------------- .../modules/deeptools/plotheatmap/main.nf | 26 ++--- .../deeptools/plotprofile/functions.nf | 78 --------------- .../modules/deeptools/plotprofile/main.nf | 26 ++--- modules/nf-core/modules/fastqc/functions.nf | 78 --------------- modules/nf-core/modules/fastqc/main.nf | 32 +++---- modules/nf-core/modules/gffread/functions.nf | 78 --------------- modules/nf-core/modules/gffread/main.nf | 26 ++--- modules/nf-core/modules/gunzip/functions.nf | 78 --------------- modules/nf-core/modules/gunzip/main.nf | 32 +++---- modules/nf-core/modules/gunzip/meta.yml | 6 ++ .../modules/homer/annotatepeaks/functions.nf | 78 --------------- .../modules/homer/annotatepeaks/main.nf | 28 ++---- .../modules/macs2/callpeak/functions.nf | 78 --------------- .../nf-core/modules/macs2/callpeak/main.nf | 37 ++++---- .../nf-core/modules/macs2/callpeak/meta.yml | 63 ++++++++++++ modules/nf-core/modules/multiqc/functions.nf | 78 --------------- modules/nf-core/modules/multiqc/main.nf | 24 ++--- .../modules/phantompeakqualtools/functions.nf | 78 --------------- .../modules/phantompeakqualtools/main.nf | 27 ++---- .../collectmultiplemetrics/functions.nf | 78 --------------- .../picard/collectmultiplemetrics/main.nf | 26 ++--- .../picard/markduplicates/functions.nf | 78 --------------- .../modules/picard/markduplicates/main.nf | 32 +++---- .../modules/picard/mergesamfiles/functions.nf | 78 --------------- .../modules/picard/mergesamfiles/main.nf | 30 ++---- .../modules/preseq/lcextrap/functions.nf | 78 --------------- .../nf-core/modules/preseq/lcextrap/main.nf | 26 ++--- .../modules/samtools/flagstat/functions.nf | 78 --------------- .../nf-core/modules/samtools/flagstat/main.nf | 26 ++--- .../modules/samtools/idxstats/functions.nf | 78 --------------- .../nf-core/modules/samtools/idxstats/main.nf | 24 ++--- .../modules/samtools/index/functions.nf | 78 --------------- .../nf-core/modules/samtools/index/main.nf | 36 +++---- .../nf-core/modules/samtools/index/meta.yml | 5 + .../modules/samtools/sort/functions.nf | 78 --------------- modules/nf-core/modules/samtools/sort/main.nf | 28 ++---- .../modules/samtools/stats/functions.nf | 78 --------------- .../nf-core/modules/samtools/stats/main.nf | 31 +++--- .../nf-core/modules/samtools/stats/meta.yml | 21 ++-- .../subread/featurecounts/functions.nf | 78 --------------- .../modules/subread/featurecounts/main.nf | 26 ++--- .../nf-core/modules/trimgalore/functions.nf | 78 --------------- modules/nf-core/modules/trimgalore/main.nf | 32 +++---- .../ucsc/bedgraphtobigwig/functions.nf | 78 --------------- .../modules/ucsc/bedgraphtobigwig/main.nf | 26 ++--- modules/nf-core/modules/untar/functions.nf | 78 --------------- modules/nf-core/modules/untar/main.nf | 28 ++---- 61 files changed, 456 insertions(+), 2722 deletions(-) delete mode 100644 modules/nf-core/modules/bwa/index/functions.nf delete mode 100644 modules/nf-core/modules/bwa/mem/functions.nf delete mode 100644 modules/nf-core/modules/custom/dumpsoftwareversions/functions.nf create mode 100644 modules/nf-core/modules/custom/dumpsoftwareversions/templates/dumpsoftwareversions.py delete mode 100644 modules/nf-core/modules/deeptools/computematrix/functions.nf delete mode 100644 modules/nf-core/modules/deeptools/plotfingerprint/functions.nf delete mode 100644 modules/nf-core/modules/deeptools/plotheatmap/functions.nf delete mode 100644 modules/nf-core/modules/deeptools/plotprofile/functions.nf delete mode 100644 modules/nf-core/modules/fastqc/functions.nf delete mode 100644 modules/nf-core/modules/gffread/functions.nf delete mode 100644 modules/nf-core/modules/gunzip/functions.nf delete mode 100644 modules/nf-core/modules/homer/annotatepeaks/functions.nf delete mode 100644 modules/nf-core/modules/macs2/callpeak/functions.nf create mode 100644 modules/nf-core/modules/macs2/callpeak/meta.yml delete mode 100644 modules/nf-core/modules/multiqc/functions.nf delete mode 100644 modules/nf-core/modules/phantompeakqualtools/functions.nf delete mode 100644 modules/nf-core/modules/picard/collectmultiplemetrics/functions.nf delete mode 100644 modules/nf-core/modules/picard/markduplicates/functions.nf delete mode 100644 modules/nf-core/modules/picard/mergesamfiles/functions.nf delete mode 100644 modules/nf-core/modules/preseq/lcextrap/functions.nf delete mode 100644 modules/nf-core/modules/samtools/flagstat/functions.nf delete mode 100644 modules/nf-core/modules/samtools/idxstats/functions.nf delete mode 100644 modules/nf-core/modules/samtools/index/functions.nf delete mode 100644 modules/nf-core/modules/samtools/sort/functions.nf delete mode 100644 modules/nf-core/modules/samtools/stats/functions.nf delete mode 100644 modules/nf-core/modules/subread/featurecounts/functions.nf delete mode 100644 modules/nf-core/modules/trimgalore/functions.nf delete mode 100644 modules/nf-core/modules/ucsc/bedgraphtobigwig/functions.nf delete mode 100644 modules/nf-core/modules/untar/functions.nf diff --git a/modules.json b/modules.json index 1d5fdedc8..f56ae271e 100644 --- a/modules.json +++ b/modules.json @@ -4,85 +4,85 @@ "repos": { "nf-core/modules": { "bwa/index": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, "bwa/mem": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "custom/dumpsoftwareversions": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, "deeptools/computematrix": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "deeptools/plotfingerprint": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "deeptools/plotheatmap": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "deeptools/plotprofile": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "fastqc": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "gffread": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, "gunzip": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, "homer/annotatepeaks": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "macs2/callpeak": { - "git_sha": "7b3315591a149609e27914965f858c9a7e071564" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "multiqc": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, "phantompeakqualtools": { - "git_sha": "7b3315591a149609e27914965f858c9a7e071564" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "picard/collectmultiplemetrics": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "picard/markduplicates": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "picard/mergesamfiles": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "preseq/lcextrap": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "samtools/flagstat": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, "samtools/idxstats": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, "samtools/index": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, "samtools/sort": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "samtools/stats": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, "subread/featurecounts": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "trimgalore": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "ucsc/bedgraphtobigwig": { - "git_sha": "49da8642876ae4d91128168cd0db4f1c858d7792" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "untar": { - "git_sha": "3aacd46da2b221ed47aaa05c413a828538d2c2ae" + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" } } } diff --git a/modules/nf-core/modules/bwa/index/functions.nf b/modules/nf-core/modules/bwa/index/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/bwa/index/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/bwa/index/main.nf b/modules/nf-core/modules/bwa/index/main.nf index 479431eda..891027377 100644 --- a/modules/nf-core/modules/bwa/index/main.nf +++ b/modules/nf-core/modules/bwa/index/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process BWA_INDEX { tag "$fasta" label 'process_high' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'index', meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "bioconda::bwa=0.7.17" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/bwa:0.7.17--hed695b0_7" - } else { - container "quay.io/biocontainers/bwa:0.7.17--hed695b0_7" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/bwa:0.7.17--hed695b0_7' : + 'quay.io/biocontainers/bwa:0.7.17--hed695b0_7' }" input: path fasta @@ -26,17 +15,18 @@ process BWA_INDEX { path "versions.yml", emit: versions script: + def args = task.ext.args ?: '' """ mkdir bwa bwa \\ index \\ - $options.args \\ - $fasta \\ - -p bwa/${fasta.baseName} + $args \\ + -p bwa/${fasta.baseName} \\ + $fasta cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//') + "${task.process}": + bwa: \$(echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//') END_VERSIONS """ } diff --git a/modules/nf-core/modules/bwa/mem/functions.nf b/modules/nf-core/modules/bwa/mem/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/bwa/mem/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/bwa/mem/main.nf b/modules/nf-core/modules/bwa/mem/main.nf index b6a548d7d..801293a8f 100644 --- a/modules/nf-core/modules/bwa/mem/main.nf +++ b/modules/nf-core/modules/bwa/mem/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process BWA_MEM { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::bwa=0.7.17 bioconda::samtools=1.12" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:66ed1b38d280722529bb8a0167b0cf02f8a0b488-0" - } else { - container "quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:66ed1b38d280722529bb8a0167b0cf02f8a0b488-0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:66ed1b38d280722529bb8a0167b0cf02f8a0b488-0' : + 'quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:66ed1b38d280722529bb8a0167b0cf02f8a0b488-0' }" input: tuple val(meta), path(reads) @@ -27,22 +16,24 @@ process BWA_MEM { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def args2 = task.ext.args2 ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" def read_group = meta.read_group ? "-R ${meta.read_group}" : "" """ INDEX=`find -L ./ -name "*.amb" | sed 's/.amb//'` bwa mem \\ - $options.args \\ + $args \\ $read_group \\ -t $task.cpus \\ \$INDEX \\ $reads \\ - | samtools view $options.args2 -@ $task.cpus -bhS -o ${prefix}.bam - + | samtools view $args2 -@ $task.cpus -bhS -o ${prefix}.bam - cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//') + "${task.process}": + bwa: \$(echo \$(bwa 2>&1) | sed 's/^.*Version: //; s/Contact:.*\$//') samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS """ diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/functions.nf b/modules/nf-core/modules/custom/dumpsoftwareversions/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/custom/dumpsoftwareversions/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf b/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf index faf2073f7..934bb4672 100644 --- a/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process CUSTOM_DUMPSOFTWAREVERSIONS { label 'process_low' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'pipeline_info', meta:[:], publish_by_meta:[]) } // Requires `pyyaml` which does not have a dedicated container but is in the MultiQC container conda (params.enable_conda ? "bioconda::multiqc=1.11" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/multiqc:1.11--pyhdfd78af_0" - } else { - container "quay.io/biocontainers/multiqc:1.11--pyhdfd78af_0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/multiqc:1.11--pyhdfd78af_0' : + 'quay.io/biocontainers/multiqc:1.11--pyhdfd78af_0' }" input: path versions @@ -27,80 +16,6 @@ process CUSTOM_DUMPSOFTWAREVERSIONS { path "versions.yml" , emit: versions script: - """ - #!/usr/bin/env python - - import yaml - import platform - from textwrap import dedent - - def _make_versions_html(versions): - html = [ - dedent( - '''\\ - - - - - - - - - - ''' - ) - ] - for process, tmp_versions in sorted(versions.items()): - html.append("") - for i, (tool, version) in enumerate(sorted(tmp_versions.items())): - html.append( - dedent( - f'''\\ - - - - - - ''' - ) - ) - html.append("") - html.append("
Process Name Software Version
{process if (i == 0) else ''}{tool}{version}
") - return "\\n".join(html) - - module_versions = {} - module_versions["${getProcessName(task.process)}"] = { - 'python': platform.python_version(), - 'yaml': yaml.__version__ - } - - with open("$versions") as f: - workflow_versions = yaml.load(f, Loader=yaml.BaseLoader) | module_versions - - workflow_versions["Workflow"] = { - "Nextflow": "$workflow.nextflow.version", - "$workflow.manifest.name": "$workflow.manifest.version" - } - - versions_mqc = { - 'id': 'software_versions', - 'section_name': '${workflow.manifest.name} Software Versions', - 'section_href': 'https://github.com/${workflow.manifest.name}', - 'plot_type': 'html', - 'description': 'are collected at run time from the software output.', - 'data': _make_versions_html(workflow_versions) - } - - with open("software_versions.yml", 'w') as f: - yaml.dump(workflow_versions, f, default_flow_style=False) - with open("software_versions_mqc.yml", 'w') as f: - yaml.dump(versions_mqc, f, default_flow_style=False) - - with open('versions.yml', 'w') as f: - yaml.dump(module_versions, f, default_flow_style=False) - """ + def args = task.ext.args ?: '' + template 'dumpsoftwareversions.py' } diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml b/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml index c8310e356..5b5b8a602 100644 --- a/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml @@ -31,3 +31,4 @@ output: authors: - "@drpatelh" + - "@grst" diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/templates/dumpsoftwareversions.py b/modules/nf-core/modules/custom/dumpsoftwareversions/templates/dumpsoftwareversions.py new file mode 100644 index 000000000..d13903925 --- /dev/null +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/templates/dumpsoftwareversions.py @@ -0,0 +1,89 @@ +#!/usr/bin/env python + +import yaml +import platform +from textwrap import dedent + + +def _make_versions_html(versions): + html = [ + dedent( + """\\ + + + + + + + + + + """ + ) + ] + for process, tmp_versions in sorted(versions.items()): + html.append("") + for i, (tool, version) in enumerate(sorted(tmp_versions.items())): + html.append( + dedent( + f"""\\ + + + + + + """ + ) + ) + html.append("") + html.append("
Process Name Software Version
{process if (i == 0) else ''}{tool}{version}
") + return "\\n".join(html) + + +versions_this_module = {} +versions_this_module["${task.process}"] = { + "python": platform.python_version(), + "yaml": yaml.__version__, +} + +with open("$versions") as f: + versions_by_process = yaml.load(f, Loader=yaml.BaseLoader) | versions_this_module + +# aggregate versions by the module name (derived from fully-qualified process name) +versions_by_module = {} +for process, process_versions in versions_by_process.items(): + module = process.split(":")[-1] + try: + assert versions_by_module[module] == process_versions, ( + "We assume that software versions are the same between all modules. " + "If you see this error-message it means you discovered an edge-case " + "and should open an issue in nf-core/tools. " + ) + except KeyError: + versions_by_module[module] = process_versions + +versions_by_module["Workflow"] = { + "Nextflow": "$workflow.nextflow.version", + "$workflow.manifest.name": "$workflow.manifest.version", +} + +versions_mqc = { + "id": "software_versions", + "section_name": "${workflow.manifest.name} Software Versions", + "section_href": "https://github.com/${workflow.manifest.name}", + "plot_type": "html", + "description": "are collected at run time from the software output.", + "data": _make_versions_html(versions_by_module), +} + +with open("software_versions.yml", "w") as f: + yaml.dump(versions_by_module, f, default_flow_style=False) +with open("software_versions_mqc.yml", "w") as f: + yaml.dump(versions_mqc, f, default_flow_style=False) + +with open("versions.yml", "w") as f: + yaml.dump(versions_this_module, f, default_flow_style=False) diff --git a/modules/nf-core/modules/deeptools/computematrix/functions.nf b/modules/nf-core/modules/deeptools/computematrix/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/deeptools/computematrix/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/deeptools/computematrix/main.nf b/modules/nf-core/modules/deeptools/computematrix/main.nf index 9fffdb8e8..70be934bf 100644 --- a/modules/nf-core/modules/deeptools/computematrix/main.nf +++ b/modules/nf-core/modules/deeptools/computematrix/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process DEEPTOOLS_COMPUTEMATRIX { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? 'bioconda::deeptools=3.5.1' : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/deeptools:3.5.1--py_0" - } else { - container "quay.io/biocontainers/deeptools:3.5.1--py_0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/deeptools:3.5.1--py_0' : + 'quay.io/biocontainers/deeptools:3.5.1--py_0' }" input: tuple val(meta), path(bigwig) @@ -28,10 +17,11 @@ process DEEPTOOLS_COMPUTEMATRIX { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" """ computeMatrix \\ - $options.args \\ + $args \\ --regionsFileName $bed \\ --scoreFileName $bigwig \\ --outFileName ${prefix}.computeMatrix.mat.gz \\ @@ -39,8 +29,8 @@ process DEEPTOOLS_COMPUTEMATRIX { --numberOfProcessors $task.cpus cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(computeMatrix --version | sed -e "s/computeMatrix //g") + "${task.process}": + deeptools: \$(computeMatrix --version | sed -e "s/computeMatrix //g") END_VERSIONS """ } diff --git a/modules/nf-core/modules/deeptools/plotfingerprint/functions.nf b/modules/nf-core/modules/deeptools/plotfingerprint/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/deeptools/plotfingerprint/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/deeptools/plotfingerprint/main.nf b/modules/nf-core/modules/deeptools/plotfingerprint/main.nf index b2d167f9b..7925c9a97 100644 --- a/modules/nf-core/modules/deeptools/plotfingerprint/main.nf +++ b/modules/nf-core/modules/deeptools/plotfingerprint/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process DEEPTOOLS_PLOTFINGERPRINT { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? 'bioconda::deeptools=3.5.1' : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/deeptools:3.5.1--py_0" - } else { - container "quay.io/biocontainers/deeptools:3.5.1--py_0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/deeptools:3.5.1--py_0' : + 'quay.io/biocontainers/deeptools:3.5.1--py_0' }" input: tuple val(meta), path(bams), path(bais) @@ -28,11 +17,12 @@ process DEEPTOOLS_PLOTFINGERPRINT { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" def extend = (meta.single_end && params.fragment_size > 0) ? "--extendReads ${params.fragment_size}" : '' """ plotFingerprint \\ - $options.args \\ + $args \\ $extend \\ --bamfiles ${bams.join(' ')} \\ --plotFile ${prefix}.plotFingerprint.pdf \\ @@ -41,8 +31,8 @@ process DEEPTOOLS_PLOTFINGERPRINT { --numberOfProcessors $task.cpus cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(plotFingerprint --version | sed -e "s/plotFingerprint //g") + "${task.process}": + deeptools: \$(plotFingerprint --version | sed -e "s/plotFingerprint //g") END_VERSIONS """ } diff --git a/modules/nf-core/modules/deeptools/plotheatmap/functions.nf b/modules/nf-core/modules/deeptools/plotheatmap/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/deeptools/plotheatmap/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/deeptools/plotheatmap/main.nf b/modules/nf-core/modules/deeptools/plotheatmap/main.nf index 19c243dfb..992c90583 100644 --- a/modules/nf-core/modules/deeptools/plotheatmap/main.nf +++ b/modules/nf-core/modules/deeptools/plotheatmap/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process DEEPTOOLS_PLOTHEATMAP { tag "$meta.id" label 'process_low' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? 'bioconda::deeptools=3.5.1' : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/deeptools:3.5.1--py_0" - } else { - container "quay.io/biocontainers/deeptools:3.5.1--py_0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/deeptools:3.5.1--py_0' : + 'quay.io/biocontainers/deeptools:3.5.1--py_0' }" input: tuple val(meta), path(matrix) @@ -27,17 +16,18 @@ process DEEPTOOLS_PLOTHEATMAP { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" """ plotHeatmap \\ - $options.args \\ + $args \\ --matrixFile $matrix \\ --outFileName ${prefix}.plotHeatmap.pdf \\ --outFileNameMatrix ${prefix}.plotHeatmap.mat.tab cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(plotHeatmap --version | sed -e "s/plotHeatmap //g") + "${task.process}": + deeptools: \$(plotHeatmap --version | sed -e "s/plotHeatmap //g") END_VERSIONS """ } diff --git a/modules/nf-core/modules/deeptools/plotprofile/functions.nf b/modules/nf-core/modules/deeptools/plotprofile/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/deeptools/plotprofile/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/deeptools/plotprofile/main.nf b/modules/nf-core/modules/deeptools/plotprofile/main.nf index 3a196bd51..60184fa6b 100644 --- a/modules/nf-core/modules/deeptools/plotprofile/main.nf +++ b/modules/nf-core/modules/deeptools/plotprofile/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process DEEPTOOLS_PLOTPROFILE { tag "$meta.id" label 'process_low' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? 'bioconda::deeptools=3.5.1' : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/deeptools:3.5.1--py_0" - } else { - container "quay.io/biocontainers/deeptools:3.5.1--py_0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/deeptools:3.5.1--py_0' : + 'quay.io/biocontainers/deeptools:3.5.1--py_0' }" input: tuple val(meta), path(matrix) @@ -27,17 +16,18 @@ process DEEPTOOLS_PLOTPROFILE { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" """ plotProfile \\ - $options.args \\ + $args \\ --matrixFile $matrix \\ --outFileName ${prefix}.plotProfile.pdf \\ --outFileNameData ${prefix}.plotProfile.tab cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(plotProfile --version | sed -e "s/plotProfile //g") + "${task.process}": + deeptools: \$(plotProfile --version | sed -e "s/plotProfile //g") END_VERSIONS """ } diff --git a/modules/nf-core/modules/fastqc/functions.nf b/modules/nf-core/modules/fastqc/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/fastqc/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/fastqc/main.nf b/modules/nf-core/modules/fastqc/main.nf index 9f6cfc553..d250eca07 100644 --- a/modules/nf-core/modules/fastqc/main.nf +++ b/modules/nf-core/modules/fastqc/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process FASTQC { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::fastqc=0.11.9" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0" - } else { - container "quay.io/biocontainers/fastqc:0.11.9--0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0' : + 'quay.io/biocontainers/fastqc:0.11.9--0' }" input: tuple val(meta), path(reads) @@ -27,27 +16,28 @@ process FASTQC { path "versions.yml" , emit: versions script: + def args = task.ext.args ?: '' // Add soft-links to original FastQs for consistent naming in pipeline - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def prefix = task.ext.prefix ?: "${meta.id}" if (meta.single_end) { """ [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz - fastqc $options.args --threads $task.cpus ${prefix}.fastq.gz + fastqc $args --threads $task.cpus ${prefix}.fastq.gz cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$( fastqc --version | sed -e "s/FastQC v//g" ) + "${task.process}": + fastqc: \$( fastqc --version | sed -e "s/FastQC v//g" ) END_VERSIONS """ } else { """ [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz - fastqc $options.args --threads $task.cpus ${prefix}_1.fastq.gz ${prefix}_2.fastq.gz + fastqc $args --threads $task.cpus ${prefix}_1.fastq.gz ${prefix}_2.fastq.gz cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$( fastqc --version | sed -e "s/FastQC v//g" ) + "${task.process}": + fastqc: \$( fastqc --version | sed -e "s/FastQC v//g" ) END_VERSIONS """ } diff --git a/modules/nf-core/modules/gffread/functions.nf b/modules/nf-core/modules/gffread/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/gffread/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/gffread/main.nf b/modules/nf-core/modules/gffread/main.nf index 4133ee087..d31f76f82 100644 --- a/modules/nf-core/modules/gffread/main.nf +++ b/modules/nf-core/modules/gffread/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process GFFREAD { tag "$gff" label 'process_low' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "bioconda::gffread=0.12.1" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/gffread:0.12.1--h8b12597_0" - } else { - container "quay.io/biocontainers/gffread:0.12.1--h8b12597_0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/gffread:0.12.1--h8b12597_0' : + 'quay.io/biocontainers/gffread:0.12.1--h8b12597_0' }" input: path gff @@ -26,15 +15,16 @@ process GFFREAD { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${gff.baseName}${options.suffix}" : "${gff.baseName}" + def args = task.ext.args ?: '' + def prefix = task.ext.suffix ? "${gff.baseName}${task.ext.suffix}" : "${gff.baseName}" """ gffread \\ $gff \\ - $options.args \\ + $args \\ -o ${prefix}.gtf cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(gffread --version 2>&1) + "${task.process}": + gffread: \$(gffread --version 2>&1) END_VERSIONS """ } diff --git a/modules/nf-core/modules/gunzip/functions.nf b/modules/nf-core/modules/gunzip/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/gunzip/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/gunzip/main.nf b/modules/nf-core/modules/gunzip/main.nf index aec4569fa..77a4e546b 100644 --- a/modules/nf-core/modules/gunzip/main.nf +++ b/modules/nf-core/modules/gunzip/main.nf @@ -1,41 +1,31 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process GUNZIP { tag "$archive" label 'process_low' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "conda-forge::sed=4.7" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://containers.biocontainers.pro/s3/SingImgsRepo/biocontainers/v1.2.0_cv1/biocontainers_v1.2.0_cv1.img" - } else { - container "biocontainers/biocontainers:v1.2.0_cv1" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://containers.biocontainers.pro/s3/SingImgsRepo/biocontainers/v1.2.0_cv1/biocontainers_v1.2.0_cv1.img' : + 'biocontainers/biocontainers:v1.2.0_cv1' }" input: - path archive + tuple val(meta), path(archive) output: - path "$gunzip", emit: gunzip - path "versions.yml" , emit: versions + tuple val(meta), path("$gunzip"), emit: gunzip + path "versions.yml" , emit: versions script: - gunzip = archive.toString() - '.gz' + def args = task.ext.args ?: '' + gunzip = archive.toString() - '.gz' """ gunzip \\ -f \\ - $options.args \\ + $args \\ $archive cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo \$(gunzip --version 2>&1) | sed 's/^.*(gzip) //; s/ Copyright.*\$//') + "${task.process}": + gunzip: \$(echo \$(gunzip --version 2>&1) | sed 's/^.*(gzip) //; s/ Copyright.*\$//') END_VERSIONS """ } diff --git a/modules/nf-core/modules/gunzip/meta.yml b/modules/nf-core/modules/gunzip/meta.yml index 3482f0d28..ea1f15460 100644 --- a/modules/nf-core/modules/gunzip/meta.yml +++ b/modules/nf-core/modules/gunzip/meta.yml @@ -10,6 +10,11 @@ tools: documentation: https://www.gnu.org/software/gzip/manual/gzip.html licence: ['GPL-3.0-or-later'] input: + - meta: + type: map + description: | + Optional groovy Map containing meta information + e.g. [ id:'test', single_end:false ] - archive: type: file description: File to be compressed/uncompressed @@ -26,3 +31,4 @@ output: authors: - "@joseespinosa" - "@drpatelh" + - "@jfy133" diff --git a/modules/nf-core/modules/homer/annotatepeaks/functions.nf b/modules/nf-core/modules/homer/annotatepeaks/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/homer/annotatepeaks/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/homer/annotatepeaks/main.nf b/modules/nf-core/modules/homer/annotatepeaks/main.nf index 1714644b8..84e0241a4 100644 --- a/modules/nf-core/modules/homer/annotatepeaks/main.nf +++ b/modules/nf-core/modules/homer/annotatepeaks/main.nf @@ -1,24 +1,13 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - -def VERSION = '4.11' +def VERSION = '4.11' // Version information not provided by tool on CLI process HOMER_ANNOTATEPEAKS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::homer=4.11" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/homer:4.11--pl526hc9558a2_3" - } else { - container "quay.io/biocontainers/homer:4.11--pl526hc9558a2_3" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/homer:4.11--pl526hc9558a2_3' : + 'quay.io/biocontainers/homer:4.11--pl526hc9558a2_3' }" input: tuple val(meta), path(peak) @@ -30,19 +19,20 @@ process HOMER_ANNOTATEPEAKS { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" """ annotatePeaks.pl \\ $peak \\ $fasta \\ - $options.args \\ + $args \\ -gtf $gtf \\ -cpu $task.cpus \\ > ${prefix}.annotatePeaks.txt cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo $VERSION) + "${task.process}": + homer: $VERSION END_VERSIONS """ } diff --git a/modules/nf-core/modules/macs2/callpeak/functions.nf b/modules/nf-core/modules/macs2/callpeak/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/macs2/callpeak/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/macs2/callpeak/main.nf b/modules/nf-core/modules/macs2/callpeak/main.nf index d54d406db..c5c88f8e0 100644 --- a/modules/nf-core/modules/macs2/callpeak/main.nf +++ b/modules/nf-core/modules/macs2/callpeak/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process MACS2_CALLPEAK { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::macs2=2.2.7.1" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py38h0213d0e_1" - } else { - container "quay.io/biocontainers/macs2:2.2.7.1--py38h0213d0e_1" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/macs2:2.2.7.1--py38h4a8c8d9_3' : + 'quay.io/biocontainers/macs2:2.2.7.1--py38h4a8c8d9_3' }" input: tuple val(meta), path(ipbam), path(controlbam) @@ -32,13 +21,21 @@ process MACS2_CALLPEAK { tuple val(meta), path("*.bdg") , optional:true, emit: bdg script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" - def format = meta.single_end ? 'BAM' : 'BAMPE' - def control = controlbam ? "--control $controlbam" : '' + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" + def args_list = args.tokenize() + def format = meta.single_end ? 'BAM' : 'BAMPE' + def control = controlbam ? "--control $controlbam" : '' + if(args_list.contains('--format')){ + def id = args_list.findIndexOf{it=='--format'} + format = args_list[id+1] + args_list.remove(id+1) + args_list.remove(id) + } """ macs2 \\ callpeak \\ - $options.args \\ + ${args_list.join(' ')} \\ --gsize $macs2_gsize \\ --format $format \\ --name $prefix \\ @@ -46,8 +43,8 @@ process MACS2_CALLPEAK { $control cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(macs2 --version | sed -e "s/macs2 //g") + "${task.process}": + macs2: \$(macs2 --version | sed -e "s/macs2 //g") END_VERSIONS """ } diff --git a/modules/nf-core/modules/macs2/callpeak/meta.yml b/modules/nf-core/modules/macs2/callpeak/meta.yml new file mode 100644 index 000000000..afb949ece --- /dev/null +++ b/modules/nf-core/modules/macs2/callpeak/meta.yml @@ -0,0 +1,63 @@ +name: macs2_callpeak +description: Peak calling of enriched genomic regions of ChIP-seq and ATAC-seq experiments +keywords: + - alignment + - atac-seq + - chip-seq + - peak-calling +tools: + - macs2: + description: Model Based Analysis for ChIP-Seq data + homepage: None + documentation: https://docs.csc.fi/apps/macs2/ + tool_dev_url: https://github.com/macs3-project/MACS + doi: "https://doi.org/10.1101/496521" + licence: ['BSD'] + +input: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - ipbam: + type: file + description: The ChIP-seq treatment file + - controlbam: + type: file + description: The control file + - macs2_gsize: + type: string + description: Effective genome size. It can be 1.0e+9 or 1000000000, or shortcuts:'hs' for human (2.7e9), + 'mm' for mouse (1.87e9), 'ce' for C. elegans (9e7) and 'dm' for fruitfly (1.2e8) + +output: + - versions: + type: file + description: File containing software version + pattern: "versions.yml" + - peak: + type: file + description: BED file containing annotated peaks + pattern: "*.gappedPeak,*.narrowPeak}" + - xls: + type: file + description: xls file containing annotated peaks + pattern: "*.xls" + - gapped: + type: file + description: Optional BED file containing gapped peak + pattern: "*.gappedPeak" + - bed: + type: file + description: Optional BED file containing peak summits locations for every peak + pattern: "*.bed" + - bdg: + type: file + description: Optional bedGraph files for input and treatment input samples + pattern: "*.bdg" + +authors: + - "@ntoda03" + - "@JoseEspinosa" + - "@jianhong" diff --git a/modules/nf-core/modules/multiqc/functions.nf b/modules/nf-core/modules/multiqc/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/multiqc/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/multiqc/main.nf b/modules/nf-core/modules/multiqc/main.nf index 0861aa593..3dceb162a 100644 --- a/modules/nf-core/modules/multiqc/main.nf +++ b/modules/nf-core/modules/multiqc/main.nf @@ -1,21 +1,10 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process MULTIQC { label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? 'bioconda::multiqc=1.11' : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/multiqc:1.11--pyhdfd78af_0" - } else { - container "quay.io/biocontainers/multiqc:1.11--pyhdfd78af_0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/multiqc:1.11--pyhdfd78af_0' : + 'quay.io/biocontainers/multiqc:1.11--pyhdfd78af_0' }" input: path multiqc_files @@ -27,12 +16,13 @@ process MULTIQC { path "versions.yml" , emit: versions script: + def args = task.ext.args ?: '' """ - multiqc -f $options.args . + multiqc -f $args . cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$( multiqc --version | sed -e "s/multiqc, version //g" ) + "${task.process}": + multiqc: \$( multiqc --version | sed -e "s/multiqc, version //g" ) END_VERSIONS """ } diff --git a/modules/nf-core/modules/phantompeakqualtools/functions.nf b/modules/nf-core/modules/phantompeakqualtools/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/phantompeakqualtools/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/phantompeakqualtools/main.nf b/modules/nf-core/modules/phantompeakqualtools/main.nf index b390bf7e2..6fe34cc28 100644 --- a/modules/nf-core/modules/phantompeakqualtools/main.nf +++ b/modules/nf-core/modules/phantompeakqualtools/main.nf @@ -1,24 +1,13 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - -def VERSION = '1.2.2' +def VERSION = '1.2.2' // Version information not provided by tool on CLI process PHANTOMPEAKQUALTOOLS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::phantompeakqualtools=1.2.2" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/phantompeakqualtools:1.2.2--0" - } else { - container "quay.io/biocontainers/phantompeakqualtools:1.2.2--0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/phantompeakqualtools:1.2.2--0' : + 'quay.io/biocontainers/phantompeakqualtools:1.2.2--0' }" input: tuple val(meta), path(bam) @@ -30,13 +19,15 @@ process PHANTOMPEAKQUALTOOLS { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" """ RUN_SPP=`which run_spp.R` Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus + cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo $VERSION) + "${task.process}": + phantompeakqualtools: $VERSION END_VERSIONS """ } diff --git a/modules/nf-core/modules/picard/collectmultiplemetrics/functions.nf b/modules/nf-core/modules/picard/collectmultiplemetrics/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/picard/collectmultiplemetrics/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf b/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf index dd8fdacaa..6b292534c 100644 --- a/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf +++ b/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process PICARD_COLLECTMULTIPLEMETRICS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? 'bioconda::picard=2.25.7' : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/picard:2.25.7--hdfd78af_0" - } else { - container "quay.io/biocontainers/picard:2.25.7--hdfd78af_0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/picard:2.25.7--hdfd78af_0' : + 'quay.io/biocontainers/picard:2.25.7--hdfd78af_0' }" input: tuple val(meta), path(bam) @@ -28,7 +17,8 @@ process PICARD_COLLECTMULTIPLEMETRICS { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" def avail_mem = 3 if (!task.memory) { log.info '[Picard CollectMultipleMetrics] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' @@ -39,14 +29,14 @@ process PICARD_COLLECTMULTIPLEMETRICS { picard \\ -Xmx${avail_mem}g \\ CollectMultipleMetrics \\ - $options.args \\ + $args \\ INPUT=$bam \\ OUTPUT=${prefix}.CollectMultipleMetrics \\ REFERENCE_SEQUENCE=$fasta cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(picard CollectMultipleMetrics --version 2>&1 | grep -o 'Version.*' | cut -f2- -d:) + "${task.process}": + picard: \$(picard CollectMultipleMetrics --version 2>&1 | grep -o 'Version.*' | cut -f2- -d:) END_VERSIONS """ } diff --git a/modules/nf-core/modules/picard/markduplicates/functions.nf b/modules/nf-core/modules/picard/markduplicates/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/picard/markduplicates/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/picard/markduplicates/main.nf b/modules/nf-core/modules/picard/markduplicates/main.nf index 37b825d78..d3bf69385 100644 --- a/modules/nf-core/modules/picard/markduplicates/main.nf +++ b/modules/nf-core/modules/picard/markduplicates/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process PICARD_MARKDUPLICATES { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? 'bioconda::picard=2.25.7' : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/picard:2.25.7--hdfd78af_0" - } else { - container "quay.io/biocontainers/picard:2.25.7--hdfd78af_0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/picard:2.25.7--hdfd78af_0' : + 'quay.io/biocontainers/picard:2.25.7--hdfd78af_0' }" input: tuple val(meta), path(bam) @@ -28,7 +17,8 @@ process PICARD_MARKDUPLICATES { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" def avail_mem = 3 if (!task.memory) { log.info '[Picard MarkDuplicates] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' @@ -39,14 +29,14 @@ process PICARD_MARKDUPLICATES { picard \\ -Xmx${avail_mem}g \\ MarkDuplicates \\ - $options.args \\ - -I $bam \\ - -O ${prefix}.bam \\ - -M ${prefix}.MarkDuplicates.metrics.txt + $args \\ + I=$bam \\ + O=${prefix}.bam \\ + M=${prefix}.MarkDuplicates.metrics.txt cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo \$(picard MarkDuplicates --version 2>&1) | grep -o 'Version:.*' | cut -f2- -d:) + "${task.process}": + picard: \$(echo \$(picard MarkDuplicates --version 2>&1) | grep -o 'Version:.*' | cut -f2- -d:) END_VERSIONS """ } diff --git a/modules/nf-core/modules/picard/mergesamfiles/functions.nf b/modules/nf-core/modules/picard/mergesamfiles/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/picard/mergesamfiles/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/picard/mergesamfiles/main.nf b/modules/nf-core/modules/picard/mergesamfiles/main.nf index 355c0bf3b..867965932 100644 --- a/modules/nf-core/modules/picard/mergesamfiles/main.nf +++ b/modules/nf-core/modules/picard/mergesamfiles/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process PICARD_MERGESAMFILES { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? 'bioconda::picard=2.25.7' : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/picard:2.25.7--hdfd78af_0" - } else { - container "quay.io/biocontainers/picard:2.25.7--hdfd78af_0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/picard:2.25.7--hdfd78af_0' : + 'quay.io/biocontainers/picard:2.25.7--hdfd78af_0' }" input: tuple val(meta), path(bams) @@ -26,7 +15,8 @@ process PICARD_MERGESAMFILES { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" def bam_files = bams.sort() def avail_mem = 3 if (!task.memory) { @@ -39,20 +29,20 @@ process PICARD_MERGESAMFILES { picard \\ -Xmx${avail_mem}g \\ MergeSamFiles \\ - $options.args \\ + $args \\ ${'INPUT='+bam_files.join(' INPUT=')} \\ OUTPUT=${prefix}.bam cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$( echo \$(picard MergeSamFiles --version 2>&1) | grep -o 'Version:.*' | cut -f2- -d:) + "${task.process}": + picard: \$( echo \$(picard MergeSamFiles --version 2>&1) | grep -o 'Version:.*' | cut -f2- -d:) END_VERSIONS """ } else { """ ln -s ${bam_files[0]} ${prefix}.bam cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$( echo \$(picard MergeSamFiles --version 2>&1) | grep -o 'Version:.*' | cut -f2- -d:) + "${task.process}": + picard: \$( echo \$(picard MergeSamFiles --version 2>&1) | grep -o 'Version:.*' | cut -f2- -d:) END_VERSIONS """ } diff --git a/modules/nf-core/modules/preseq/lcextrap/functions.nf b/modules/nf-core/modules/preseq/lcextrap/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/preseq/lcextrap/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/preseq/lcextrap/main.nf b/modules/nf-core/modules/preseq/lcextrap/main.nf index f551a5493..b5bd06206 100644 --- a/modules/nf-core/modules/preseq/lcextrap/main.nf +++ b/modules/nf-core/modules/preseq/lcextrap/main.nf @@ -1,23 +1,12 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process PRESEQ_LCEXTRAP { tag "$meta.id" label 'process_medium' label 'error_ignore' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::preseq=3.1.2" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/preseq:3.1.2--h06ef8b0_1" - } else { - container "quay.io/biocontainers/preseq:3.1.2--h06ef8b0_1" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/preseq:3.1.2--h06ef8b0_1' : + 'quay.io/biocontainers/preseq:3.1.2--h06ef8b0_1' }" input: tuple val(meta), path(bam) @@ -28,20 +17,21 @@ process PRESEQ_LCEXTRAP { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" def paired_end = meta.single_end ? '' : '-pe' """ preseq \\ lc_extrap \\ - $options.args \\ + $args \\ $paired_end \\ -output ${prefix}.ccurve.txt \\ $bam cp .command.err ${prefix}.command.log cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo \$(preseq 2>&1) | sed 's/^.*Version: //; s/Usage:.*\$//') + "${task.process}": + preseq: \$(echo \$(preseq 2>&1) | sed 's/^.*Version: //; s/Usage:.*\$//') END_VERSIONS """ } diff --git a/modules/nf-core/modules/samtools/flagstat/functions.nf b/modules/nf-core/modules/samtools/flagstat/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/samtools/flagstat/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/samtools/flagstat/main.nf b/modules/nf-core/modules/samtools/flagstat/main.nf index f9115c6bb..03721d0b2 100644 --- a/modules/nf-core/modules/samtools/flagstat/main.nf +++ b/modules/nf-core/modules/samtools/flagstat/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process SAMTOOLS_FLAGSTAT { tag "$meta.id" label 'process_low' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } - conda (params.enable_conda ? 'bioconda::samtools=1.13' : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/samtools:1.13--h8c37831_0" - } else { - container "quay.io/biocontainers/samtools:1.13--h8c37831_0" - } + conda (params.enable_conda ? "bioconda::samtools=1.14" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/samtools:1.14--hb421002_0' : + 'quay.io/biocontainers/samtools:1.14--hb421002_0' }" input: tuple val(meta), path(bam), path(bai) @@ -26,11 +15,12 @@ process SAMTOOLS_FLAGSTAT { path "versions.yml" , emit: versions script: + def args = task.ext.args ?: '' """ - samtools flagstat $bam > ${bam}.flagstat + samtools flagstat --threads ${task.cpus-1} $bam > ${bam}.flagstat cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + "${task.process}": + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS """ } diff --git a/modules/nf-core/modules/samtools/idxstats/functions.nf b/modules/nf-core/modules/samtools/idxstats/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/samtools/idxstats/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/samtools/idxstats/main.nf b/modules/nf-core/modules/samtools/idxstats/main.nf index b005088ab..cd0686791 100644 --- a/modules/nf-core/modules/samtools/idxstats/main.nf +++ b/modules/nf-core/modules/samtools/idxstats/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process SAMTOOLS_IDXSTATS { tag "$meta.id" label 'process_low' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } - conda (params.enable_conda ? 'bioconda::samtools=1.13' : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/samtools:1.13--h8c37831_0" - } else { - container "quay.io/biocontainers/samtools:1.13--h8c37831_0" - } + conda (params.enable_conda ? "bioconda::samtools=1.14" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/samtools:1.14--hb421002_0' : + 'quay.io/biocontainers/samtools:1.14--hb421002_0' }" input: tuple val(meta), path(bam), path(bai) @@ -26,11 +15,12 @@ process SAMTOOLS_IDXSTATS { path "versions.yml" , emit: versions script: + def args = task.ext.args ?: '' """ samtools idxstats $bam > ${bam}.idxstats cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + "${task.process}": + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS """ } diff --git a/modules/nf-core/modules/samtools/index/functions.nf b/modules/nf-core/modules/samtools/index/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/samtools/index/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/samtools/index/main.nf b/modules/nf-core/modules/samtools/index/main.nf index febbc11ca..b033e2258 100644 --- a/modules/nf-core/modules/samtools/index/main.nf +++ b/modules/nf-core/modules/samtools/index/main.nf @@ -1,37 +1,29 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process SAMTOOLS_INDEX { tag "$meta.id" label 'process_low' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } - conda (params.enable_conda ? 'bioconda::samtools=1.13' : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/samtools:1.13--h8c37831_0" - } else { - container "quay.io/biocontainers/samtools:1.13--h8c37831_0" - } + conda (params.enable_conda ? "bioconda::samtools=1.14" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/samtools:1.14--hb421002_0' : + 'quay.io/biocontainers/samtools:1.14--hb421002_0' }" input: - tuple val(meta), path(bam) + tuple val(meta), path(input) output: - tuple val(meta), path("*.bai"), optional:true, emit: bai - tuple val(meta), path("*.csi"), optional:true, emit: csi - path "versions.yml" , emit: versions + tuple val(meta), path("*.bai") , optional:true, emit: bai + tuple val(meta), path("*.crai"), optional:true, emit: crai + tuple val(meta), path("*.csi") , optional:true, emit: csi + path "versions.yml" , emit: versions script: + def args = task.ext.args ?: '' """ - samtools index $options.args $bam + samtools index -@ ${task.cpus-1} $args $input + cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + "${task.process}": + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS """ } diff --git a/modules/nf-core/modules/samtools/index/meta.yml b/modules/nf-core/modules/samtools/index/meta.yml index 988e8f53b..0905b3cd6 100644 --- a/modules/nf-core/modules/samtools/index/meta.yml +++ b/modules/nf-core/modules/samtools/index/meta.yml @@ -35,6 +35,10 @@ output: type: file description: BAM/CRAM/SAM index file pattern: "*.{bai,crai,sai}" + - crai: + type: file + description: BAM/CRAM/SAM index file + pattern: "*.{bai,crai,sai}" - csi: type: file description: CSI index file @@ -46,3 +50,4 @@ output: authors: - "@drpatelh" - "@ewels" + - "@maxulysse" diff --git a/modules/nf-core/modules/samtools/sort/functions.nf b/modules/nf-core/modules/samtools/sort/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/samtools/sort/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/samtools/sort/main.nf b/modules/nf-core/modules/samtools/sort/main.nf index b30f6f45c..0c2cf25e3 100644 --- a/modules/nf-core/modules/samtools/sort/main.nf +++ b/modules/nf-core/modules/samtools/sort/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process SAMTOOLS_SORT { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } - conda (params.enable_conda ? 'bioconda::samtools=1.13' : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/samtools:1.13--h8c37831_0" - } else { - container "quay.io/biocontainers/samtools:1.13--h8c37831_0" - } + conda (params.enable_conda ? "bioconda::samtools=1.14" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/samtools:1.14--hb421002_0' : + 'quay.io/biocontainers/samtools:1.14--hb421002_0' }" input: tuple val(meta), path(bam) @@ -26,12 +15,13 @@ process SAMTOOLS_SORT { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" """ - samtools sort $options.args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam + samtools sort $args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + "${task.process}": + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS """ } diff --git a/modules/nf-core/modules/samtools/stats/functions.nf b/modules/nf-core/modules/samtools/stats/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/samtools/stats/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/samtools/stats/main.nf b/modules/nf-core/modules/samtools/stats/main.nf index 6218dd2dd..83c870025 100644 --- a/modules/nf-core/modules/samtools/stats/main.nf +++ b/modules/nf-core/modules/samtools/stats/main.nf @@ -1,36 +1,29 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process SAMTOOLS_STATS { tag "$meta.id" label 'process_low' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } - conda (params.enable_conda ? 'bioconda::samtools=1.13' : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/samtools:1.13--h8c37831_0" - } else { - container "quay.io/biocontainers/samtools:1.13--h8c37831_0" - } + conda (params.enable_conda ? "bioconda::samtools=1.14" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/samtools:1.14--hb421002_0' : + 'quay.io/biocontainers/samtools:1.14--hb421002_0' }" input: - tuple val(meta), path(bam), path(bai) + tuple val(meta), path(input), path(input_index) + path fasta output: tuple val(meta), path("*.stats"), emit: stats path "versions.yml" , emit: versions script: + def args = task.ext.args ?: '' + def reference = fasta ? "--reference ${fasta}" : "" """ - samtools stats $bam > ${bam}.stats + samtools stats --threads ${task.cpus-1} ${reference} ${input} > ${input}.stats + cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + "${task.process}": + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS """ } diff --git a/modules/nf-core/modules/samtools/stats/meta.yml b/modules/nf-core/modules/samtools/stats/meta.yml index ae41498a2..869e62e37 100644 --- a/modules/nf-core/modules/samtools/stats/meta.yml +++ b/modules/nf-core/modules/samtools/stats/meta.yml @@ -22,14 +22,18 @@ input: description: | Groovy Map containing sample information e.g. [ id:'test', single_end:false ] - - bam: - type: file - description: BAM/CRAM/SAM file - pattern: "*.{bam,cram,sam}" - - bai: - type: file - description: Index for BAM/CRAM/SAM file - pattern: "*.{bai,crai,sai}" + - input: + type: file + description: BAM/CRAM file from alignment + pattern: "*.{bam,cram}" + - input_index: + type: file + description: BAI/CRAI file from alignment + pattern: "*.{bai,crai}" + - fasta: + type: optional file + description: Reference file the CRAM was created with + pattern: "*.{fasta,fa}" output: - meta: type: map @@ -46,3 +50,4 @@ output: pattern: "versions.yml" authors: - "@drpatelh" + - "@FriederikeHanssen" diff --git a/modules/nf-core/modules/subread/featurecounts/functions.nf b/modules/nf-core/modules/subread/featurecounts/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/subread/featurecounts/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/subread/featurecounts/main.nf b/modules/nf-core/modules/subread/featurecounts/main.nf index 0a0285dbf..53eb279e1 100644 --- a/modules/nf-core/modules/subread/featurecounts/main.nf +++ b/modules/nf-core/modules/subread/featurecounts/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process SUBREAD_FEATURECOUNTS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::subread=2.0.1" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0" - } else { - container "quay.io/biocontainers/subread:2.0.1--hed695b0_0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/subread:2.0.1--hed695b0_0' : + 'quay.io/biocontainers/subread:2.0.1--hed695b0_0' }" input: tuple val(meta), path(bams), path(annotation) @@ -27,7 +16,8 @@ process SUBREAD_FEATURECOUNTS { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" def paired_end = meta.single_end ? '' : '-p' def strandedness = 0 @@ -38,7 +28,7 @@ process SUBREAD_FEATURECOUNTS { } """ featureCounts \\ - $options.args \\ + $args \\ $paired_end \\ -T $task.cpus \\ -a $annotation \\ @@ -47,8 +37,8 @@ process SUBREAD_FEATURECOUNTS { ${bams.join(' ')} cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$( echo \$(featureCounts -v 2>&1) | sed -e "s/featureCounts v//g") + "${task.process}": + subread: \$( echo \$(featureCounts -v 2>&1) | sed -e "s/featureCounts v//g") END_VERSIONS """ } diff --git a/modules/nf-core/modules/trimgalore/functions.nf b/modules/nf-core/modules/trimgalore/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/trimgalore/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/trimgalore/main.nf b/modules/nf-core/modules/trimgalore/main.nf index 8e77f1f77..ee40b780b 100644 --- a/modules/nf-core/modules/trimgalore/main.nf +++ b/modules/nf-core/modules/trimgalore/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process TRIMGALORE { tag "$meta.id" label 'process_high' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? 'bioconda::trim-galore=0.6.7' : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/trim-galore:0.6.7--hdfd78af_0" - } else { - container "quay.io/biocontainers/trim-galore:0.6.7--hdfd78af_0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/trim-galore:0.6.7--hdfd78af_0' : + 'quay.io/biocontainers/trim-galore:0.6.7--hdfd78af_0' }" input: tuple val(meta), path(reads) @@ -30,6 +19,7 @@ process TRIMGALORE { tuple val(meta), path("*.zip") , emit: zip optional true script: + def args = task.ext.args ?: '' // Calculate number of --cores for TrimGalore based on value of task.cpus // See: https://github.com/FelixKrueger/TrimGalore/blob/master/Changelog.md#version-060-release-on-1-mar-2019 // See: https://github.com/nf-core/atacseq/pull/65 @@ -48,20 +38,20 @@ process TRIMGALORE { def tpc_r2 = params.three_prime_clip_r2 > 0 ? "--three_prime_clip_r2 ${params.three_prime_clip_r2}" : '' // Added soft-links to original fastqs for consistent naming in MultiQC - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def prefix = task.ext.prefix ?: "${meta.id}" if (meta.single_end) { """ [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz trim_galore \\ - $options.args \\ + $args \\ --cores $cores \\ --gzip \\ $c_r1 \\ $tpc_r1 \\ ${prefix}.fastq.gz cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//') + "${task.process}": + trimgalore: \$(echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//') cutadapt: \$(cutadapt --version) END_VERSIONS """ @@ -70,7 +60,7 @@ process TRIMGALORE { [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz trim_galore \\ - $options.args \\ + $args \\ --cores $cores \\ --paired \\ --gzip \\ @@ -81,8 +71,8 @@ process TRIMGALORE { ${prefix}_1.fastq.gz \\ ${prefix}_2.fastq.gz cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//') + "${task.process}": + trimgalore: \$(echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//') cutadapt: \$(cutadapt --version) END_VERSIONS """ diff --git a/modules/nf-core/modules/ucsc/bedgraphtobigwig/functions.nf b/modules/nf-core/modules/ucsc/bedgraphtobigwig/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/ucsc/bedgraphtobigwig/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/ucsc/bedgraphtobigwig/main.nf b/modules/nf-core/modules/ucsc/bedgraphtobigwig/main.nf index f55cdb078..9ba306aba 100644 --- a/modules/nf-core/modules/ucsc/bedgraphtobigwig/main.nf +++ b/modules/nf-core/modules/ucsc/bedgraphtobigwig/main.nf @@ -1,24 +1,13 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - -def VERSION = '377' +def VERSION = '377' // Version information not provided by tool on CLI process UCSC_BEDGRAPHTOBIGWIG { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::ucsc-bedgraphtobigwig=377" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/ucsc-bedgraphtobigwig:377--h446ed27_1" - } else { - container "quay.io/biocontainers/ucsc-bedgraphtobigwig:377--h446ed27_1" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/ucsc-bedgraphtobigwig:377--h446ed27_1' : + 'quay.io/biocontainers/ucsc-bedgraphtobigwig:377--h446ed27_1' }" input: tuple val(meta), path(bedgraph) @@ -29,7 +18,8 @@ process UCSC_BEDGRAPHTOBIGWIG { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" """ bedGraphToBigWig \\ $bedgraph \\ @@ -37,8 +27,8 @@ process UCSC_BEDGRAPHTOBIGWIG { ${prefix}.bigWig cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo $VERSION) + "${task.process}": + ucsc: $VERSION END_VERSIONS """ } diff --git a/modules/nf-core/modules/untar/functions.nf b/modules/nf-core/modules/untar/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/nf-core/modules/untar/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/nf-core/modules/untar/main.nf b/modules/nf-core/modules/untar/main.nf index efb9d8251..6d1996e77 100644 --- a/modules/nf-core/modules/untar/main.nf +++ b/modules/nf-core/modules/untar/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process UNTAR { tag "$archive" label 'process_low' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "conda-forge::sed=4.7" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://containers.biocontainers.pro/s3/SingImgsRepo/biocontainers/v1.2.0_cv1/biocontainers_v1.2.0_cv1.img" - } else { - container "biocontainers/biocontainers:v1.2.0_cv1" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://containers.biocontainers.pro/s3/SingImgsRepo/biocontainers/v1.2.0_cv1/biocontainers_v1.2.0_cv1.img' : + 'biocontainers/biocontainers:v1.2.0_cv1' }" input: path archive @@ -26,16 +15,19 @@ process UNTAR { path "versions.yml", emit: versions script: + def args = task.ext.args ?: '' + def args2 = task.ext.args2 ?: '' untar = archive.toString() - '.tar.gz' """ tar \\ -xzvf \\ - $options.args \\ - $archive + $args \\ + $archive \\ + $args2 \\ cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(echo \$(tar --version 2>&1) | sed 's/^.*(GNU tar) //; s/ Copyright.*\$//') + "${task.process}": + untar: \$(echo \$(tar --version 2>&1) | sed 's/^.*(GNU tar) //; s/ Copyright.*\$//') END_VERSIONS """ } From 37dbf883116afc294120269ba458b79e9cd7f093 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 2 Dec 2021 23:46:59 +0100 Subject: [PATCH 252/538] Update local modules to new DSL2 --- modules/local/bam_filter.nf | 21 ++--- modules/local/bam_remove_orphans.nf | 26 ++----- modules/local/bedtools_genomecov.nf | 27 ++----- modules/local/frip_score.nf | 24 ++---- modules/local/functions.nf | 78 ------------------- modules/local/genome_blacklist_regions.nf | 20 ++--- modules/local/get_chrom_sizes.nf | 15 +--- modules/local/gtf2bed.nf | 18 +---- modules/local/igv.nf | 18 +---- modules/local/macs2_consensus.nf | 18 ++--- modules/local/multiqc.nf | 22 ++---- modules/local/multiqc_custom_peaks.nf | 20 +---- .../multiqc_custom_phantompeakqualtools.nf | 23 ++---- modules/local/plot_homer_annotatepeaks.nf | 22 ++---- modules/local/plot_macs2_qc.nf | 22 ++---- modules/local/samplesheet_check.nf | 18 +---- 16 files changed, 81 insertions(+), 311 deletions(-) delete mode 100644 modules/local/functions.nf diff --git a/modules/local/bam_filter.nf b/modules/local/bam_filter.nf index b6a17db8e..6b31709df 100644 --- a/modules/local/bam_filter.nf +++ b/modules/local/bam_filter.nf @@ -1,25 +1,14 @@ -// Import generic module functions -include { initOptions; saveFiles; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - /* * Filter BAM file */ process BAM_FILTER { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::bamtools=2.4.0 bioconda::samtools=1.4.1" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/mulled-v2-0560a8046fc82aa4338588eca29ff18edab2c5aa:fc33176431a4b9ef3213640937e641d731db04f1-0" - } else { - container "quay.io/biocontainers/mulled-v2-0560a8046fc82aa4338588eca29ff18edab2c5aa:fc33176431a4b9ef3213640937e641d731db04f1-0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/mulled-v2-0560a8046fc82aa4338588eca29ff18edab2c5aa:fc33176431a4b9ef3213640937e641d731db04f1-0' : + 'quay.io/biocontainers/mulled-v2-0560a8046fc82aa4338588eca29ff18edab2c5aa:fc33176431a4b9ef3213640937e641d731db04f1-0' }" input: tuple val(meta), path(bam), path(bai) @@ -32,7 +21,7 @@ process BAM_FILTER { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def prefix = task.ext.prefix ?: "${meta.id}" def filter_params = meta.single_end ? '-F 0x004' : '-F 0x004 -F 0x0008 -f 0x001' def dup_params = params.keep_dups ? '' : '-F 0x0400' def multimap_params = params.keep_multi_map ? '' : '-q 1' @@ -50,7 +39,7 @@ process BAM_FILTER { -script $config cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') bamtools: \$(echo \$(bamtools --version 2>&1) | sed 's/^.*bamtools //; s/Part .*\$//') END_VERSIONS diff --git a/modules/local/bam_remove_orphans.nf b/modules/local/bam_remove_orphans.nf index 5c6ce5086..d25ccae02 100644 --- a/modules/local/bam_remove_orphans.nf +++ b/modules/local/bam_remove_orphans.nf @@ -1,25 +1,14 @@ -// Import generic module functions -include { initOptions; saveFiles; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - /* * Remove orphan reads from paired-end BAM file */ process BAM_REMOVE_ORPHANS { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::pysam=0.16.0.1 bioconda::samtools=1.13" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/mulled-v2-57736af1eb98c01010848572c9fec9fff6ffaafd:980645707aa512b63b32c44c35888ac1dab126dd-0" - } else { - container "quay.io/biocontainers/mulled-v2-57736af1eb98c01010848572c9fec9fff6ffaafd:980645707aa512b63b32c44c35888ac1dab126dd-0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/mulled-v2-57736af1eb98c01010848572c9fec9fff6ffaafd:980645707aa512b63b32c44c35888ac1dab126dd-0' : + 'quay.io/biocontainers/mulled-v2-57736af1eb98c01010848572c9fec9fff6ffaafd:980645707aa512b63b32c44c35888ac1dab126dd-0' }" input: tuple val(meta), path(bam) @@ -29,14 +18,15 @@ process BAM_REMOVE_ORPHANS { path "versions.yml" , emit: versions script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args?: '' + def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" if (!meta.single_end) { """ samtools sort -n -@ $task.cpus -o ${prefix}.name.sorted.bam -T ${prefix}.name.sorted $bam - bampe_rm_orphan.py ${prefix}.name.sorted.bam ${prefix}.bam $options.args + bampe_rm_orphan.py ${prefix}.name.sorted.bam ${prefix}.bam $args cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS """ @@ -45,7 +35,7 @@ process BAM_REMOVE_ORPHANS { ln -s $bam ${prefix}.bam cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS """ diff --git a/modules/local/bedtools_genomecov.nf b/modules/local/bedtools_genomecov.nf index 95b54e49d..76fd991b2 100644 --- a/modules/local/bedtools_genomecov.nf +++ b/modules/local/bedtools_genomecov.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process BEDTOOLS_GENOMECOV { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::bedtools=2.30.0" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/bedtools:2.30.0--hc088bd4_0" - } else { - container "quay.io/biocontainers/bedtools:2.30.0--hc088bd4_0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/bedtools:2.30.0--hc088bd4_0': + 'quay.io/biocontainers/bedtools:2.30.0--hc088bd4_0' }" input: tuple val(meta), path(bam), path(flagstat) @@ -27,10 +16,10 @@ process BEDTOOLS_GENOMECOV { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def prefix = task.ext.prefix ?: "${meta.id}" - def pe = meta.single_end ? '' : '-pc' - def extend = (meta.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' + def pe = meta.single_end ? '' : '-pc' + def extend = (meta.single_end && params.fragment_size > 0) ? "-fs ${params.fragment_size}" : '' """ SCALE_FACTOR=\$(grep '[0-9] mapped (' $flagstat | awk '{print 1000000/\$1}') echo \$SCALE_FACTOR > ${prefix}.scale_factor.txt @@ -45,8 +34,8 @@ process BEDTOOLS_GENOMECOV { | sort -T '.' -k1,1 -k2,2n > ${prefix}.bedGraph cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: - ${getSoftwareName(task.process)}: \$(bedtools --version | sed -e "s/bedtools v//g") + "${task.process}": + bedtools: \$(bedtools --version | sed -e "s/bedtools v//g") END_VERSIONS """ } diff --git a/modules/local/frip_score.nf b/modules/local/frip_score.nf index ad9123b72..6a364c58c 100644 --- a/modules/local/frip_score.nf +++ b/modules/local/frip_score.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process FRIP_SCORE { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::bedtools=2.30.0 bioconda::samtools=1.9" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/mulled-v2-8186960447c5cb2faa697666dc1e6d919ad23f3e:2200fd433290bb814a952b2fd7cc8013499de840-0" - } else { - container "quay.io/biocontainers/mulled-v2-8186960447c5cb2faa697666dc1e6d919ad23f3e:2200fd433290bb814a952b2fd7cc8013499de840-0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/mulled-v2-8186960447c5cb2faa697666dc1e6d919ad23f3e:2200fd433290bb814a952b2fd7cc8013499de840-': + 'quay.io/biocontainers/mulled-v2-8186960447c5cb2faa697666dc1e6d919ad23f3e:2200fd433290bb814a952b2fd7cc8013499de840-0' }" input: tuple val(meta), path(bam), path(peak) @@ -26,14 +15,15 @@ process FRIP_SCORE { path "versions.yml" , emit: versions script: - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" """ - READS_IN_PEAKS=\$(intersectBed -a $bam -b $peak $options.args | awk -F '\t' '{sum += \$NF} END {print sum}') + READS_IN_PEAKS=\$(intersectBed -a $bam -b $peak $args | awk -F '\t' '{sum += \$NF} END {print sum}') samtools flagstat $bam > ${bam}.flagstat grep 'mapped (' ${bam}.flagstat | awk -v a="\$READS_IN_PEAKS" -v OFS='\t' '{print "${prefix}", a/\$1}' > ${prefix}.FRiP.txt cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": bedtools: \$(bedtools --version | sed -e "s/bedtools v//g") samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS diff --git a/modules/local/functions.nf b/modules/local/functions.nf deleted file mode 100644 index 85628ee0e..000000000 --- a/modules/local/functions.nf +++ /dev/null @@ -1,78 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Extract name of module from process name using $task.process -// -def getProcessName(task_process) { - return task_process.tokenize(':')[-1] -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - - // Do not publish versions.yml unless running from pytest workflow - if (args.filename.equals('versions.yml') && !System.getenv("NF_CORE_MODULES_TEST")) { - return null - } - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } -} diff --git a/modules/local/genome_blacklist_regions.nf b/modules/local/genome_blacklist_regions.nf index 35d0610ae..1a28af0f6 100644 --- a/modules/local/genome_blacklist_regions.nf +++ b/modules/local/genome_blacklist_regions.nf @@ -1,23 +1,13 @@ -// Import generic module functions -include { saveFiles; getProcessName } from './functions' - -params.options = [:] - /* * Prepare genome intervals for filtering by removing regions in blacklist file */ process GENOME_BLACKLIST_REGIONS { tag "$sizes" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'genome', meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "bioconda::bedtools=2.30.0" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/bedtools:2.30.0--hc088bd4_0" - } else { - container "quay.io/biocontainers/bedtools:2.30.0--hc088bd4_0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/bedtools:2.30.0--hc088bd4_0': + 'quay.io/biocontainers/bedtools:2.30.0--hc088bd4_0' }" input: path sizes @@ -34,7 +24,7 @@ process GENOME_BLACKLIST_REGIONS { sortBed -i $blacklist -g $sizes | complementBed -i stdin -g $sizes > $file_out cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": bedtools: \$(bedtools --version | sed -e "s/bedtools v//g") END_VERSIONS """ @@ -43,7 +33,7 @@ process GENOME_BLACKLIST_REGIONS { awk '{print \$1, '0' , \$2}' OFS='\t' $sizes > $file_out cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": bedtools: \$(bedtools --version | sed -e "s/bedtools v//g") END_VERSIONS """ diff --git a/modules/local/get_chrom_sizes.nf b/modules/local/get_chrom_sizes.nf index b9fa2ac92..3009d8164 100644 --- a/modules/local/get_chrom_sizes.nf +++ b/modules/local/get_chrom_sizes.nf @@ -1,8 +1,3 @@ -// Import generic module functions -include { saveFiles; getProcessName } from './functions' - -params.options = [:] - process GET_CHROM_SIZES { tag "$fasta" publishDir "${params.outdir}", @@ -10,11 +5,9 @@ process GET_CHROM_SIZES { saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'genome', meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "bioconda::samtools=1.10" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2" - } else { - container "quay.io/biocontainers/samtools:1.10--h9402c20_2" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2': + 'quay.io/biocontainers/samtools:1.10--h9402c20_2' }" input: path fasta @@ -33,7 +26,7 @@ process GET_CHROM_SIZES { cut -f 1,2 ${fasta}.fai > ${fasta}.sizes cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS """ diff --git a/modules/local/gtf2bed.nf b/modules/local/gtf2bed.nf index ea2519c81..1d306cee5 100644 --- a/modules/local/gtf2bed.nf +++ b/modules/local/gtf2bed.nf @@ -1,21 +1,11 @@ -// Import generic module functions -include { saveFiles; getProcessName } from './functions' - -params.options = [:] - process GTF2BED { tag "$gtf" label 'process_low' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'genome', meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "conda-forge::perl=5.26.2" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/perl:5.26.2" - } else { - container "quay.io/biocontainers/perl:5.26.2" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/perl:5.26.2': + 'quay.io/biocontainers/perl:5.26.2' }" input: path gtf @@ -31,7 +21,7 @@ process GTF2BED { > ${gtf.baseName}.bed cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": perl: \$(echo \$(perl --version 2>&1) | sed 's/.*v\\(.*\\)) built.*/\\1/') END_VERSIONS """ diff --git a/modules/local/igv.nf b/modules/local/igv.nf index 29798880a..e70ccfa8e 100644 --- a/modules/local/igv.nf +++ b/modules/local/igv.nf @@ -1,22 +1,12 @@ -// Import generic module functions -include { saveFiles; getProcessName } from './functions' - -params.options = [:] - /* * Create IGV session file */ process IGV { - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "conda-forge::python=3.8.3" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/python:3.8.3" - } else { - container "quay.io/biocontainers/python:3.8.3" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/python:3.8.3': + 'quay.io/biocontainers/python:3.8.3' }" input: path fasta @@ -42,7 +32,7 @@ process IGV { igv_files_to_session.py igv_session.xml igv_files.txt ../../genome/${fasta.getName()} --path_prefix '../../' cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": python: \$(python --version | sed 's/Python //g') END_VERSIONS """ diff --git a/modules/local/macs2_consensus.nf b/modules/local/macs2_consensus.nf index 53248d5f9..46d2de245 100644 --- a/modules/local/macs2_consensus.nf +++ b/modules/local/macs2_consensus.nf @@ -1,9 +1,3 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - /* * Consensus peaks across samples, create boolean filtering file, SAF file for featureCounts */ @@ -15,11 +9,9 @@ process MACS2_CONSENSUS { saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "conda-forge::biopython conda-forge::r-optparse=1.7.1 conda-forge::r-upsetr=1.4.0 bioconda::bedtools=2.30.0" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/mulled-v2-2f48cc59b03027e31ead6d383fe1b8057785dd24:5d182f583f4696f4c4d9f3be93052811b383341f-0" - } else { - container "quay.io/biocontainers/mulled-v2-2f48cc59b03027e31ead6d383fe1b8057785dd24:5d182f583f4696f4c4d9f3be93052811b383341f-0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/mulled-v2-2f48cc59b03027e31ead6d383fe1b8057785dd24:5d182f583f4696f4c4d9f3be93052811b383341f-0': + 'quay.io/biocontainers/mulled-v2-2f48cc59b03027e31ead6d383fe1b8057785dd24:5d182f583f4696f4c4d9f3be93052811b383341f-0' }" input: tuple val(meta), path(peaks) @@ -34,7 +26,7 @@ process MACS2_CONSENSUS { script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ if (meta.multiple_groups || meta.replicates_exist) { - def prefix = options.suffix ? "${meta.id}${options.suffix}.consensus_peaks" : "${meta.id}.consensus_peaks" + def prefix = task.ext.prefix ? "${task.ext.prefix}.consensus_peaks": "${meta.id}.consensus_peaks" def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' def mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') def collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') @@ -58,7 +50,7 @@ process MACS2_CONSENSUS { plot_peak_intersect.r -i ${prefix}.boolean.intersect.txt -o ${prefix}.boolean.intersect.plot.pdf cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": python: \$(python --version | sed 's/Python //g') r-base: \$(echo \$(R --version 2>&1) | sed 's/^.*R version //; s/ .*\$//') END_VERSIONS diff --git a/modules/local/multiqc.nf b/modules/local/multiqc.nf index 319549e60..9983722f7 100644 --- a/modules/local/multiqc.nf +++ b/modules/local/multiqc.nf @@ -1,21 +1,10 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process MULTIQC { label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "bioconda::multiqc=1.10.1" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/multiqc:1.10.1--pyhdfd78af_1" - } else { - container "quay.io/biocontainers/multiqc:1.10.1--pyhdfd78af_1" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/multiqc:1.10.1--pyhdfd78af_1': + 'quay.io/biocontainers/multiqc:1.10.1--pyhdfd78af_1' }" input: path multiqc_config @@ -63,16 +52,17 @@ process MULTIQC { path "versions.yml" , emit: versions script: + def args = task.ext.args ?: '' def custom_config = params.multiqc_config ? "--config $mqc_custom_config" : '' """ multiqc \\ -f \\ - $options.args \\ + $args \\ $custom_config \\ . cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": ${getSoftwareName(task.process)}: \$( multiqc --version | sed -e "s/multiqc, version //g" ) END_VERSIONS """ diff --git a/modules/local/multiqc_custom_peaks.nf b/modules/local/multiqc_custom_peaks.nf index 9f9141f4d..de90cc75d 100644 --- a/modules/local/multiqc_custom_peaks.nf +++ b/modules/local/multiqc_custom_peaks.nf @@ -1,20 +1,9 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process MULTIQC_CUSTOM_PEAKS { - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "conda-forge::sed=4.7" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://containers.biocontainers.pro/s3/SingImgsRepo/biocontainers/v1.2.0_cv1/biocontainers_v1.2.0_cv1.img" - } else { - container "biocontainers/biocontainers:v1.2.0_cv1" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://containers.biocontainers.pro/s3/SingImgsRepo/biocontainers/v1.2.0_cv1/biocontainers_v1.2.0_cv1.img': + 'biocontainers/biocontainers:v1.2.0_cv1' }" input: tuple val(meta), path(peak), path(frip) @@ -26,8 +15,7 @@ process MULTIQC_CUSTOM_PEAKS { tuple val(meta), path("*.FRiP_mqc.tsv"), emit: frip script: - def software = getSoftwareName(task.process) - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def prefix = task.ext.prefix ?: "${meta.id}" """ cat $peak | wc -l | awk -v OFS='\t' '{ print "${prefix}", \$1 }' | cat $peak_count_header - > ${prefix}.peak_count_mqc.tsv cat $frip_score_header $frip > ${prefix}.FRiP_mqc.tsv diff --git a/modules/local/multiqc_custom_phantompeakqualtools.nf b/modules/local/multiqc_custom_phantompeakqualtools.nf index a62557e2f..7a13f7e51 100644 --- a/modules/local/multiqc_custom_phantompeakqualtools.nf +++ b/modules/local/multiqc_custom_phantompeakqualtools.nf @@ -1,21 +1,9 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:[:], publish_by_meta:[]) } - //TODO substitute with a newest tag (see https://github.com/BioContainers/containers/issues/416) conda (params.enable_conda ? "conda-forge::r-base=3.5.1" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/r-base:3.5.1" - } else { - container "quay.io/biocontainers/r-base:3.5.1" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/r-base:3.5.1': + 'quay.io/biocontainers/r-base:3.5.1' }" input: tuple val(meta), path(spp), path(rdata) @@ -29,8 +17,7 @@ process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { tuple val(meta), path("*.spp_correlation_mqc.tsv"), emit: correlation script: - def software = getSoftwareName(task.process) - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def prefix = task.ext.prefix ?: "${meta.id}" """ cp $correlation_header ${prefix}.spp_correlation_mqc.tsv Rscript -e "load('$rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}.spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" @@ -39,7 +26,7 @@ process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { awk -v OFS='\t' '{print "${meta.id}", \$10}' $spp | cat $rsc_header - > ${prefix}.spp_rsc_mqc.tsv cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": r-base: \$(echo \$(R --version 2>&1) | sed 's/^.*R version //; s/ .*\$//') END_VERSIONS """ diff --git a/modules/local/plot_homer_annotatepeaks.nf b/modules/local/plot_homer_annotatepeaks.nf index 2cd9b654e..523d13252 100644 --- a/modules/local/plot_homer_annotatepeaks.nf +++ b/modules/local/plot_homer_annotatepeaks.nf @@ -1,24 +1,13 @@ -// Import generic module functions -include { saveFiles; initOptions; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - /* * Aggregated QC plots for peak-to-gene annotation */ process PLOT_HOMER_ANNOTATEPEAKS { label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "conda-forge::r-base=4.0.3 conda-forge::r-reshape2=1.4.4 conda-forge::r-optparse=1.6.6 conda-forge::r-ggplot2=3.3.3 conda-forge::r-scales=1.1.1 conda-forge::r-viridis=0.5.1 conda-forge::r-tidyverse=1.3.0 bioconda::bioconductor-biostrings=2.58.0 bioconda::bioconductor-complexheatmap=2.6.2" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/mulled-v2-ad9dd5f398966bf899ae05f8e7c54d0fb10cdfa7:05678da05b8e5a7a5130e90a9f9a6c585b965afa-0" - } else { - container "quay.io/biocontainers/mulled-v2-ad9dd5f398966bf899ae05f8e7c54d0fb10cdfa7:05678da05b8e5a7a5130e90a9f9a6c585b965afa-0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/mulled-v2-ad9dd5f398966bf899ae05f8e7c54d0fb10cdfa7:05678da05b8e5a7a5130e90a9f9a6c585b965afa-0': + 'quay.io/biocontainers/mulled-v2-ad9dd5f398966bf899ae05f8e7c54d0fb10cdfa7:05678da05b8e5a7a5130e90a9f9a6c585b965afa-0' }" input: path annos @@ -32,16 +21,17 @@ process PLOT_HOMER_ANNOTATEPEAKS { path "versions.yml", emit: versions script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + def args = task.ext.args ?: '' """ plot_homer_annotatepeaks.r \\ -i ${annos.join(',')} \\ -s ${annos.join(',').replaceAll("${suffix}","")} \\ - $options.args + $args find ./ -type f -name "*.txt" -exec cat {} \\; | cat $mqc_header - > annotatepeaks.summary_mqc.tsv cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": r-base: \$(echo \$(R --version 2>&1) | sed 's/^.*R version //; s/ .*\$//') END_VERSIONS """ diff --git a/modules/local/plot_macs2_qc.nf b/modules/local/plot_macs2_qc.nf index 3f5590481..b47e7068b 100644 --- a/modules/local/plot_macs2_qc.nf +++ b/modules/local/plot_macs2_qc.nf @@ -1,24 +1,13 @@ -// Import generic module functions -include { initOptions; saveFiles; getProcessName } from './functions' - -params.options = [:] -options = initOptions(params.options) - /* * Aggregated QC plots for peaks */ process PLOT_MACS2_QC { label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:task.process.toLowerCase(), meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "conda-forge::r-base=4.0.3 conda-forge::r-reshape2=1.4.4 conda-forge::r-optparse=1.6.6 conda-forge::r-ggplot2=3.3.3 conda-forge::r-scales=1.1.1 conda-forge::r-viridis=0.5.1 conda-forge::r-tidyverse=1.3.0 bioconda::bioconductor-biostrings=2.58.0 bioconda::bioconductor-complexheatmap=2.6.2" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/mulled-v2-ad9dd5f398966bf899ae05f8e7c54d0fb10cdfa7:05678da05b8e5a7a5130e90a9f9a6c585b965afa-0" - } else { - container "quay.io/biocontainers/mulled-v2-ad9dd5f398966bf899ae05f8e7c54d0fb10cdfa7:05678da05b8e5a7a5130e90a9f9a6c585b965afa-0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/mulled-v2-ad9dd5f398966bf899ae05f8e7c54d0fb10cdfa7:05678da05b8e5a7a5130e90a9f9a6c585b965afa-0': + 'quay.io/biocontainers/mulled-v2-ad9dd5f398966bf899ae05f8e7c54d0fb10cdfa7:05678da05b8e5a7a5130e90a9f9a6c585b965afa-0' }" input: path peaks @@ -29,15 +18,16 @@ process PLOT_MACS2_QC { path "versions.yml", emit: versions script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ + def args = task.ext.args ?: '' def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' """ plot_macs2_qc.r \\ -i ${peaks.join(',')} \\ -s ${peaks.join(',').replaceAll("_peaks.${peak_type}","")} \\ - $options.args + $args cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": r-base: \$(echo \$(R --version 2>&1) | sed 's/^.*R version //; s/ .*\$//') END_VERSIONS """ diff --git a/modules/local/samplesheet_check.nf b/modules/local/samplesheet_check.nf index 533d149e5..20f568191 100644 --- a/modules/local/samplesheet_check.nf +++ b/modules/local/samplesheet_check.nf @@ -1,20 +1,10 @@ -// Import generic module functions -include { saveFiles; getProcessName } from './functions' - -params.options = [:] - process SAMPLESHEET_CHECK { tag "$samplesheet" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'pipeline_info', meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "conda-forge::python=3.8.3" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/python:3.8.3" - } else { - container "quay.io/biocontainers/python:3.8.3" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/python:3.8.3': + 'quay.io/biocontainers/python:3.8.3' }" input: path samplesheet @@ -30,7 +20,7 @@ process SAMPLESHEET_CHECK { samplesheet.valid.csv cat <<-END_VERSIONS > versions.yml - ${getProcessName(task.process)}: + "${task.process}": python: \$(python --version | sed 's/Python //g') END_VERSIONS """ From d635ee04cba8d32e5586f3c9aee73765e5ee1655 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 9 Dec 2021 22:19:19 +0100 Subject: [PATCH 253/538] Remore publishDir from get_chrom_sizes --- modules/local/get_chrom_sizes.nf | 3 --- 1 file changed, 3 deletions(-) diff --git a/modules/local/get_chrom_sizes.nf b/modules/local/get_chrom_sizes.nf index 3009d8164..335bba2fd 100644 --- a/modules/local/get_chrom_sizes.nf +++ b/modules/local/get_chrom_sizes.nf @@ -1,8 +1,5 @@ process GET_CHROM_SIZES { tag "$fasta" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'genome', meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "bioconda::samtools=1.10" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? From 9b4a4411053e05b4c3cfe099e23ee828bffc83f8 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 13 Dec 2021 23:16:58 +0100 Subject: [PATCH 254/538] First working version of dsl2 v2.0 pipeline --- .github/workflows/ci.yml | 4 +- conf/modules.config | 831 ++++++++++++++---- modules/local/bam_remove_orphans.nf | 4 +- modules/local/bedtools_genomecov.nf | 2 +- modules/local/macs2_consensus.nf | 3 - modules/local/multiqc.nf | 2 +- nextflow.config | 6 +- subworkflows/local/filter_bam_bamtools.nf | 18 +- subworkflows/local/input_check.nf | 4 +- subworkflows/local/prepare_genome.nf | 21 +- subworkflows/nf-core/align_bwa_mem.nf | 12 +- subworkflows/nf-core/bam_sort_samtools.nf | 12 +- subworkflows/nf-core/bam_stats_samtools.nf | 10 +- .../nf-core/mark_duplicates_picard.nf | 12 +- workflows/chipseq.nf | 198 +++-- 15 files changed, 821 insertions(+), 318 deletions(-) diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index ac99350ad..7bfda24b1 100755 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -22,8 +22,8 @@ jobs: NXF_ANSI_LOG: false strategy: matrix: - # Nextflow versions: check pipeline minimum and current latest - nxf_ver: ['21.04.0', ''] + # Nextflow versions: check pipeline minimum and latest edge version + nxf_ver: ["NXF_VER=21.04.0", "NXF_EDGE=1"] steps: - name: Check out pipeline code uses: actions/checkout@v2 diff --git a/conf/modules.config b/conf/modules.config index 60e19e047..cc86eff03 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -1,170 +1,679 @@ /* -======================================================================================== - Config file for defining DSL2 per module options -======================================================================================== +======================================================================================================== + Config file for defining DSL2 per module options and publishing paths +======================================================================================================== Available keys to override module options: - args = Additional arguments appended to command in module. - args2 = Second set of arguments appended to command in module (multi-tool modules). - args3 = Third set of arguments appended to command in module (multi-tool modules). - publish_dir = Directory to publish results. - publish_by_meta = Groovy list of keys available in meta map to append as directories to "publish_dir" path - If publish_by_meta = true - Value of ${meta['id']} is appended as a directory to "publish_dir" path - If publish_by_meta = ['id', 'custompath'] - If "id" is in meta map and "custompath" isn't then "${meta['id']}/custompath/" - is appended as a directory to "publish_dir" path - If publish_by_meta = false / null - No directories are appended to "publish_dir" path - publish_files = Groovy map where key = "file_ext" and value = "directory" to publish results for that file extension - The value of "directory" is appended to the standard "publish_dir" path as defined above. - If publish_files = null (unspecified) - All files are published. - If publish_files = false - No files are published. - suffix = File name suffix for output files. ----------------------------------------------------------------------------------------- + ext.args = Additional arguments appended to command in module. + ext.args2 = Second set of arguments appended to command in module (multi-tool modules). + ext.args3 = Third set of arguments appended to command in module (multi-tool modules). + ext.prefix = File name prefix for output files. +--------------------------------------------------------------------------------------------------------- */ -params { - modules { - 'gffread' { - args = '--keep-exon-attrs -F -T' - publish_dir = 'genome' - } - 'bwa_index' { - args = "-a bwtsw" - publish_dir = "genome/index" - } - 'fastqc' { - args = "--quiet" - } - 'trimgalore' { - args = "--fastqc" - } - 'bwa_mem' { - args = "-M" - args2 = "-h -F 0x0100 -O BAM" - publish_dir = "bwa/library" - suffix = ".Lb" - } - 'samtools_sort_lib' { - publish_dir = "bwa/library" - suffix = ".Lb.sorted" - } - 'picard_mergesamfiles' { - args = "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.sorted" - } - 'picard_markduplicates' { - args = "--ASSUME_SORTED true --REMOVE_DUPLICATES false --VALIDATION_STRINGENCY LENIENT --TMP_DIR tmp" - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.mkD.sorted" - } - 'picard_markduplicates_samtools' { - args = '' - suffix = ".mLb.mkD.sorted" - publish_files = ['bai':'', 'stats':'samtools_stats', 'flagstat':'samtools_stats', 'idxstats':'samtools_stats'] - publish_dir = "bwa/mergedLibrary" - } - 'bam_filter' { - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.flT.sorted" - } - 'bam_remove_orphans' { - args = "--only_fr_pairs" - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.clN" - } - 'samtools_sort_filter' { - publish_dir = "bwa/mergedLibrary" - suffix = ".mLb.clN.sorted" - } - 'picard_collectmultiplemetrics' { - args = "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" - publish_dir = "bwa/mergedLibrary/picard_metrics" - suffix = ".mLb.clN.sorted" - } - 'preseq_lcextrap' { - args = "-verbose -bam -seed 1" - publish_dir = "bwa/mergedLibrary/preseq" - suffix = ".mLb.clN" - } - 'phantompeakqualtools' { - publish_dir = "bwa/mergedLibrary/phantompeakqualtools" - suffix = ".mLb.clN" - } - 'multiqc_custom_phantompeakqualtools' { - publish_dir = "multiqc" - publish_files = [:] - } - 'bedtools_genomecov' { - publish_dir = "bwa/mergedLibrary/bigwig" - suffix = ".mLb.clN" - } - 'ucsc_bedgraphtobigwig' { - publish_dir = "bwa/mergedLibrary/bigwig" - suffix = ".mLb.clN" - } - 'deeptools_computematrix' { - args = "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels" - publish_dir = "bwa/mergedLibrary/deeptools" - suffix = ".mLb.clN" - } - 'deeptools_plotprofile' { - publish_dir = "bwa/mergedLibrary/deeptools" - suffix = ".mLb.clN" - } - 'deeptools_plotheatmap' { - publish_dir = "bwa/mergedLibrary/deeptools" - suffix = ".mLb.clN" - } - 'deeptools_plotfingerprint' { - args = "--skipZeros" - publish_dir = "bwa/mergedLibrary/deeptools" - suffix = ".mLb.clN" - } - 'macs2_callpeak' { - args = "--keep-dup all" - publish_dir = "bwa/mergedLibrary/macs2" - } - 'frip_score' { - args = "-bed -c -f 0.20" - publish_dir = "frip" - publish_files = [:] - } - 'multiqc_custom_peaks' { - publish_dir = "multiqc" - publish_files = [:] - } - 'plot_macs2_qc' { - args = "-o ./ -p macs2_peak" - publish_dir = "bwa/mergedLibrary/macs2" - } - 'homer_annotatepeaks_macs2' { - args = "-gid" - publish_dir = "bwa/mergedLibrary/macs2" - suffix = "_peaks" - } - 'plot_homer_annotatepeaks' { - args = "-o ./ -p macs2_annotatePeaks" - publish_dir = "bwa/mergedLibrary/macs2" - } - 'macs2_consensus' { - publish_dir = "bwa/mergedLibrary/macs2" - publish_by_id = true - } - 'homer_annotatepeaks_consensus' { - args = "-gid" - publish_dir = "bwa/mergedLibrary/macs2" - publish_by_id = true - suffix = ".consensus_peaks" - } - 'subread_featurecounts' { - args = "-F SAF -O --fracOverlap 0.2" - publish_dir = "bwa/mergedLibrary/macs2" +// +// Generic process options for all workflows +// +process { + + publishDir = [ + path: { "${params.outdir}/${task.process.tokenize(':')[-1].tokenize('_')[0].toLowerCase()}" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + + withName: CUSTOM_DUMPSOFTWAREVERSIONS { + publishDir = [ + path: { "${params.outdir}/pipeline_info" }, + mode: 'copy', + pattern: '*_versions.yml' + ] + } + // + // Process options for local subworkflows + // + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:INPUT_CHECK:SAMPLESHEET_CHECK' { + publishDir = [ + path: { "${params.outdir}/pipeline_info" }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: 'GUNZIP_.*' { + publishDir = [ + path: { "${params.outdir}/genome" }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: params.save_reference + ] + } + // withName: 'UNTAR.*' { + withName: 'UNTAR' { + publishDir = [ + path: { "${params.outdir}/genome/index" }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: params.save_reference + ] + } + withName: BWA_INDEX { + ext.args = '-a bwtsw' + publishDir = [ + path: { "${params.outdir}/genome/index" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: GFFREAD { + ext.args = '--keep-exon-attrs -F -T' + publishDir = [ + path: { "${params.outdir}/genome" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: params.save_reference + ] + } + withName: GTF2BED { + publishDir = [ + path: { "${params.outdir}/genome" }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: params.save_reference + ] + } + withName: GET_CHROM_SIZES { + publishDir = [ + path: { "${params.outdir}/genome" }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: params.save_reference + ] + } + withName: GENOME_BLACKLIST_REGIONS { + publishDir = [ + path: { "${params.outdir}/genome" }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: params.save_reference + ] + } + + + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_BWA_MEM:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { + // TODO: substitute by this line when multiple aligners are implemented + // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { + ext.prefix = { "${meta.id}.Lb.sorted" } + publishDir = [ + path: { "${params.outdir}/bwa/library" }, + mode: params.publish_dir_mode, + pattern: "*.bam", + enabled: params.save_align_intermeds + ] + } + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_BWA_MEM:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { + // TODO: substitute by this line when multiple aligners are implemented + // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { + // ext.args = params.bam_csi_index ? '-c' : '' + ext.prefix = { "${meta.id}.Lb.sorted" } + publishDir = [ + path: { "${params.outdir}/bwa/library" }, + mode: params.publish_dir_mode, + pattern: '*.{bai,csi}', + enabled: params.save_align_intermeds + ] + } + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_BWA_MEM:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:.*' { + // TODO: substitute by this line when multiple aligners are implemented + // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_STATS' { + // ext.args = params.bam_csi_index ? '-c' : '' + ext.prefix = { "${meta.id}.Lb.sorted" } + publishDir = [ + path: { "${params.outdir}/bwa/library" }, + mode: params.publish_dir_mode, + pattern: "*.{stats,flagstat,idxstats}", + enabled: params.save_align_intermeds + ] + } + // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { + // ext.args = params.bam_csi_index ? '-c' : '' + // publishDir = [ + // path: { "${params.outdir}/${params.aligner}" }, + // mode: params.publish_dir_mode, + // pattern: "*.{bam,csi}", + // enabled: ( ['star_salmon','hisat2'].contains(params.aligner) && + // ( params.save_align_intermeds || + // ( !params.with_umi && params.skip_markduplicates ) + // ) + // ) || params.save_align_intermeds || params.skip_markduplicates + // ] + // } + // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:.*' { + // publishDir = [ + // path: { "${params.outdir}/${params.aligner}/samtools_stats" }, + // mode: params.publish_dir_mode, + // pattern: "*.{stats,flagstat,idxstats}" + // ] + // } +// } + +// process { + + // withName: TRIMGALORE { + // ext.args = [ + // '--fastqc', + // params.trim_nextseq > 0 ? "--nextseq ${params.trim_nextseq}" : '' + // ].join(' ').trim() + // publishDir = [ + // [ + // path: { "${params.outdir}/trimgalore/fastqc" }, + // mode: copy, + // pattern: "*.{html,zip}" + // ], + // [ + // path: { "${params.outdir}/trimgalore" }, + // mode: copy, + // pattern: "*.fq.gz", + // enabled: params.save_trimmed + // ], + // [ + // path: { "${params.outdir}/trimgalore" }, + // mode: copy, + // pattern: "*.txt" + // ] + // ] + // } + withName: BWA_MEM { + ext.args = [ + '-M', + params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' + ].join(' ').trim() + ext.args2 = '-h -F 0x0100 -O BAM' + ext.prefix = { "${meta.id}.Lb" } + publishDir = [ + path: { "${params.outdir}/bwa/library" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + // withName: SAMTOOLS_SORT_LIB { + // ext.prefix = { "${meta.id}.Lb.sorted" } + // publishDir = [ + // path: { "${params.outdir}/bwa/library" }, + // mode: 'copy', + // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + // ] + // } + withName: PICARD_MERGESAMFILES { + ext.args = 'SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' + ext.prefix = { "${meta.id}.mLb.sorted" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + // withName: PICARD_MARKDUPLICATES { + // ext.args = 'ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' + // ext.prefix = { "${meta.id}.mLb.mkD.sorted" } + // publishDir = [ + // path: { "${params.outdir}/bwa/mergedLibrary" }, + // mode: 'copy', + // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + // ] + // } + withName: BAM_FILTER { + ext.prefix = { "${meta.id}.mLb.flT.sorted" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: BAM_REMOVE_ORPHANS { + ext.args = '--only_fr_pairs' + ext.prefix = { "${meta.id}.mLb.clN" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + + // withName: SAMTOOLS_SORT_FILTER { //FILTER_BAM_BAMTOOLS //delete + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:FILTER_BAM_BAMTOOLS:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { + ext.prefix = { "${meta.id}.mLb.clN.sorted" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary" }, + mode: 'copy', + pattern: '*.{bai,csi}' + ] + } + + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:FILTER_BAM_BAMTOOLS:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { + ext.prefix = { "${meta.id}.mLb.clN.sorted" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary" }, + mode: 'copy', + pattern: "*.bam" + ] + } + + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:FILTER_BAM_BAMTOOLS:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:.*' { + ext.prefix = { "${meta.id}.mLb.clN.sorted" } + publishDir = [ + path: { "${params.outdir}/bwa/library" }, + mode: 'copy', + pattern: "*.{stats,flagstat,idxstats}" + ] + } + + withName: PICARD_COLLECTMULTIPLEMETRICS { + ext.args = 'VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' + ext.prefix = { "${meta.id}.mLb.clN.sorted" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary/picard_metrics" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: PRESEQ_LCEXTRAP { + ext.args = '-verbose -bam -seed 1' + ext.prefix = { "${meta.id}.mLb.clN" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary/preseq" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: PHANTOMPEAKQUALTOOLS { + ext.prefix = { "${meta.id}.mLb.clN" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary/phantompeakqualtools" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { + publishDir = [ + path: { "${params.outdir}/multiqc" }, + enabled: false + ] + } + withName: BEDTOOLS_GENOMECOV { + ext.prefix = { "${meta.id}.mLb.clN" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary/bigwig" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: UCSC_BEDGRAPHTOBIGWIG { + ext.prefix = { "${meta.id}.mLb.clN" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary/bigwig" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: DEEPTOOLS_COMPUTEMATRIX { + ext.args = 'scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels' + ext.prefix = { "${meta.id}.mLb.clN" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: DEEPTOOLS_PLOTPROFILE { + ext.prefix = { "${meta.id}.mLb.clN" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: DEEPTOOLS_PLOTHEATMAP { + ext.prefix = { "${meta.id}.mLb.clN" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: DEEPTOOLS_PLOTFINGERPRINT { + ext.args = [ + '--skipZeros', + "--numberOfSamples $params.fingerprint_bins" + ].join(' ').trim() + ext.prefix = { "${meta.id}.mLb.clN" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + // withName: DESEQ2_FEATURECOUNTS { + // publishDir = [ + // path: { "${params.outdir}/bwa/mergedLibrary/macs2" }, + // mode: 'copy', + // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + // ] + // } + +// } + +// if (!params.skip_alignment && !params.skip_markduplicates) { +// process { + // MARK_DUPLICATES_PICARD + withName: '.*:MARK_DUPLICATES_PICARD:PICARD_MARKDUPLICATES' { + ext.args = 'ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' + ext.prefix = { "${meta.id}.mLb.mkD.sorted" } + publishDir = [ + [ + path: { "${params.outdir}/bwa/mergedLibrary" }, + mode: 'copy', + pattern: '*metrics.txt' + ], + [ + path: { "${params.outdir}/bwa/mergedLibrary" }, + mode: 'copy', + pattern: '*.bam' + ] + ] + } + + withName: '.*:MARK_DUPLICATES_PICARD:SAMTOOLS_INDEX' { + // ext.args = params.bam_csi_index ? '-c' : '' // TODO implement it + ext.prefix = { "${meta.id}.mkD.sorted" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary" }, + mode: 'copy', + pattern: '*.{bai,csi}' + ] + } + + withName: '.*:MARK_DUPLICATES_PICARD:BAM_STATS_SAMTOOLS:.*' { + publishDir = [ + path: { "${params.outdir}/${params.aligner}/samtools_stats" }, + mode: 'copy', + pattern: '*.{stats,flagstat,idxstats}' + ] + } +// } +} + +if (!params.skip_fastqc) { + process { + withName: FASTQC { + ext.args = '--quiet' + } + } +} + +// here +if (params.macs_gsize) { + process { + withName: MACS2_CALLPEAK { + ext.args = [ + '--keep-dup all', + params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}", + params.save_macs_pileup ? '--bdg --SPMR' : '', + params.macs_fdr ? "--pvalue ${params.macs_pvalue}" : '', + params.macs_pvalue ? "--qvalue ${params.macs_fdr}" : '' + ].join(' ').trim() + publishDir = [ + path: { [ + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: FRIP_SCORE { + ext.args = '-bed -c -f 0.20' + publishDir = [ + path: { "${params.outdir}/frip" }, + enable: false + ] + } + withName: MULTIQC_CUSTOM_PEAKS { + publishDir = [ + path: { "${params.outdir}/multiqc" }, + enabled: false + ] + } + withName: PLOT_MACS2_QC { + ext.args = '-o ./ -p macs2_peak' + publishDir = [ + path: { [ + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: HOMER_ANNOTATEPEAKS_MACS2 { + ext.args = '-gid' + // ext.prefix = 'peaks' + publishDir = [ + path: { [ + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: PLOT_HOMER_ANNOTATEPEAKS { + ext.args = '-o ./ -p macs2_annotatePeaks' + publishDir = [ + path: { [ + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: MACS2_CONSENSUS { + publishDir = [ + path: { [ + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: HOMER_ANNOTATEPEAKS_CONSENSUS { + ext.args = '-gid' + ext.prefix = 'consensus_peaks' + publishDir = [ + path: { [ + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] } - 'deseq2_featurecounts' { - publish_dir = "bwa/mergedLibrary/macs2" + + withName: SUBREAD_FEATURECOUNTS { + ext.args = '-F SAF -O --fracOverlap 0.2' + publishDir = [ + path: { [ + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] } - 'multiqc' { - args = '' - publish_dir = "multiqc" + } +} + +if (!params.skip_multiqc) { + process { + withName: MULTIQC { + ext.args = params.multiqc_title ? "--title \"$params.multiqc_title\"" : '' + publishDir = [ + path: { [ + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] } } } + +// params { +// modules { +// 'gffread' { +// args = '--keep-exon-attrs -F -T' +// publish_dir = 'genome' +// } +// 'bwa_index' { +// args = "-a bwtsw" +// publish_dir = "genome/index" +// } +// 'fastqc' { +// args = "--quiet" +// } +// 'trimgalore' { +// args = "--fastqc" +// } +// 'bwa_mem' { +// args = "-M" +// args2 = "-h -F 0x0100 -O BAM" +// publish_dir = "bwa/library" +// suffix = ".Lb" +// } +// 'samtools_sort_lib' { // ALIGN_BWA_MEM +// publish_dir = "bwa/library" +// suffix = ".Lb.sorted" +// } +// 'picard_mergesamfiles' { +// args = "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" +// publish_dir = "bwa/mergedLibrary" +// suffix = ".mLb.sorted" +// } +// 'picard_markduplicates' { +// args = "--ASSUME_SORTED true --REMOVE_DUPLICATES false --VALIDATION_STRINGENCY LENIENT --TMP_DIR tmp" +// publish_dir = "bwa/mergedLibrary" +// suffix = ".mLb.mkD.sorted" +// } +// 'picard_markduplicates_samtools' { //MARK_DUPLICATES_PICARD +// args = '' +// suffix = ".mLb.mkD.sorted" +// publish_files = ['bai':'', 'stats':'samtools_stats', 'flagstat':'samtools_stats', 'idxstats':'samtools_stats'] +// publish_dir = "bwa/mergedLibrary" +// } +// 'bam_filter' { +// publish_dir = "bwa/mergedLibrary" +// suffix = ".mLb.flT.sorted" +// } +// 'bam_remove_orphans' { +// args = "--only_fr_pairs" +// publish_dir = "bwa/mergedLibrary" +// suffix = ".mLb.clN" +// } +// 'samtools_sort_filter' { //FILTER_BAM_BAMTOOLS +// publish_dir = "bwa/mergedLibrary" +// suffix = ".mLb.clN.sorted" +// } +// 'picard_collectmultiplemetrics' { +// args = "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" +// publish_dir = "bwa/mergedLibrary/picard_metrics" +// suffix = ".mLb.clN.sorted" +// } +// 'preseq_lcextrap' { +// args = "-verbose -bam -seed 1" +// publish_dir = "bwa/mergedLibrary/preseq" +// suffix = ".mLb.clN" +// } +// 'phantompeakqualtools' { +// publish_dir = "bwa/mergedLibrary/phantompeakqualtools" +// suffix = ".mLb.clN" +// } +// 'multiqc_custom_phantompeakqualtools' { +// publish_dir = "multiqc" +// publish_files = [:] +// } +// 'bedtools_genomecov' { +// publish_dir = "bwa/mergedLibrary/bigwig" +// suffix = ".mLb.clN" +// } +// 'ucsc_bedgraphtobigwig' { +// publish_dir = "bwa/mergedLibrary/bigwig" +// suffix = ".mLb.clN" +// } +// 'deeptools_computematrix' { +// args = "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels" +// publish_dir = "bwa/mergedLibrary/deeptools" +// suffix = ".mLb.clN" +// } +// 'deeptools_plotprofile' { +// publish_dir = "bwa/mergedLibrary/deeptools" +// suffix = ".mLb.clN" +// } +// 'deeptools_plotheatmap' { +// publish_dir = "bwa/mergedLibrary/deeptools" +// suffix = ".mLb.clN" +// } +// 'deeptools_plotfingerprint' { +// args = "--skipZeros" +// publish_dir = "bwa/mergedLibrary/deeptools" +// suffix = ".mLb.clN" +// } +// 'macs2_callpeak' { +// args = "--keep-dup all" +// publish_dir = "bwa/mergedLibrary/macs2" +// } +// 'frip_score' { +// args = "-bed -c -f 0.20" +// publish_dir = "frip" +// publish_files = [:] +// } +// 'multiqc_custom_peaks' { +// publish_dir = "multiqc" +// publish_files = [:] +// } +// 'plot_macs2_qc' { +// args = "-o ./ -p macs2_peak" +// publish_dir = "bwa/mergedLibrary/macs2" +// } +// 'homer_annotatepeaks_macs2' { +// args = "-gid" +// publish_dir = "bwa/mergedLibrary/macs2" +// suffix = "_peaks" +// } +// 'plot_homer_annotatepeaks' { +// args = "-o ./ -p macs2_annotatePeaks" +// publish_dir = "bwa/mergedLibrary/macs2" +// } +// 'macs2_consensus' { +// publish_dir = "bwa/mergedLibrary/macs2" +// publish_by_id = true +// } +// 'homer_annotatepeaks_consensus' { +// args = "-gid" +// publish_dir = "bwa/mergedLibrary/macs2" +// publish_by_id = true +// suffix = ".consensus_peaks" +// } +// 'subread_featurecounts' { +// args = "-F SAF -O --fracOverlap 0.2" +// publish_dir = "bwa/mergedLibrary/macs2" +// } +// 'deseq2_featurecounts' { +// publish_dir = "bwa/mergedLibrary/macs2" +// } +// 'multiqc' { +// args = '' +// publish_dir = "multiqc" +// } +// } +// } diff --git a/modules/local/bam_remove_orphans.nf b/modules/local/bam_remove_orphans.nf index d25ccae02..99ff4f932 100644 --- a/modules/local/bam_remove_orphans.nf +++ b/modules/local/bam_remove_orphans.nf @@ -18,8 +18,8 @@ process BAM_REMOVE_ORPHANS { path "versions.yml" , emit: versions script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - def args = task.ext.args?: '' - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def args = task.ext.args ?: '' + prefix = task.ext.prefix ?: "${meta.id}" if (!meta.single_end) { """ samtools sort -n -@ $task.cpus -o ${prefix}.name.sorted.bam -T ${prefix}.name.sorted $bam diff --git a/modules/local/bedtools_genomecov.nf b/modules/local/bedtools_genomecov.nf index 76fd991b2..e8cbb3f74 100644 --- a/modules/local/bedtools_genomecov.nf +++ b/modules/local/bedtools_genomecov.nf @@ -34,7 +34,7 @@ process BEDTOOLS_GENOMECOV { | sort -T '.' -k1,1 -k2,2n > ${prefix}.bedGraph cat <<-END_VERSIONS > versions.yml - "${task.process}": + "${task.process}": bedtools: \$(bedtools --version | sed -e "s/bedtools v//g") END_VERSIONS """ diff --git a/modules/local/macs2_consensus.nf b/modules/local/macs2_consensus.nf index 46d2de245..2165ca929 100644 --- a/modules/local/macs2_consensus.nf +++ b/modules/local/macs2_consensus.nf @@ -4,9 +4,6 @@ process MACS2_CONSENSUS { tag "$meta.id" label 'process_long' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "conda-forge::biopython conda-forge::r-optparse=1.7.1 conda-forge::r-upsetr=1.4.0 bioconda::bedtools=2.30.0" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? diff --git a/modules/local/multiqc.nf b/modules/local/multiqc.nf index 9983722f7..37e41984c 100644 --- a/modules/local/multiqc.nf +++ b/modules/local/multiqc.nf @@ -63,7 +63,7 @@ process MULTIQC { cat <<-END_VERSIONS > versions.yml "${task.process}": - ${getSoftwareName(task.process)}: \$( multiqc --version | sed -e "s/multiqc, version //g" ) + multiqc: \$( multiqc --version | sed -e "s/multiqc, version //g" ) END_VERSIONS """ } diff --git a/nextflow.config b/nextflow.config index 58be034c9..fefd9c631 100644 --- a/nextflow.config +++ b/nextflow.config @@ -103,9 +103,6 @@ params { // Load base.config by default for all pipelines includeConfig 'conf/base.config' -// Load modules.config for DSL2 module specific options -includeConfig 'conf/modules.config' - // Load nf-core custom profiles from different Institutions try { includeConfig "${params.custom_config_base}/nfcore_custom.config" @@ -209,6 +206,9 @@ manifest { version = '1.3.0dev' } +// Load modules.config for DSL2 module specific options +includeConfig 'conf/modules.config' + // Function to ensure that resource requirements don't go beyond // a maximum limit def check_max(obj, type) { diff --git a/subworkflows/local/filter_bam_bamtools.nf b/subworkflows/local/filter_bam_bamtools.nf index 4bcbb4f53..1ab9fec7f 100644 --- a/subworkflows/local/filter_bam_bamtools.nf +++ b/subworkflows/local/filter_bam_bamtools.nf @@ -1,15 +1,15 @@ /* * Filter BAM file */ -params.bam_filter_options = [:] -params.bam_remove_orphans_options = [:] -params.samtools_sort_options = [:] -params.samtools_index_options = [:] -params.samtools_stats_options = [:] - -include { BAM_FILTER } from '../../modules/local/bam_filter' addParams( options: params.bam_filter_options ) -include { BAM_REMOVE_ORPHANS } from '../../modules/local/bam_remove_orphans' addParams( options: params.bam_remove_orphans_options ) -include { BAM_SORT_SAMTOOLS } from '../nf-core/bam_sort_samtools' addParams( sort_options: params.samtools_sort_options, index_options: params.samtools_index_options, stats_options: params.samtools_stats_options ) +// params.bam_filter_options = [:] +// params.bam_remove_orphans_options = [:] +// params.samtools_sort_options = [:] +// params.samtools_index_options = [:] +// params.samtools_stats_options = [:] + +include { BAM_FILTER } from '../../modules/local/bam_filter' //addParams( options: params.bam_filter_options ) +include { BAM_REMOVE_ORPHANS } from '../../modules/local/bam_remove_orphans' //addParams( options: params.bam_remove_orphans_options ) +include { BAM_SORT_SAMTOOLS } from '../nf-core/bam_sort_samtools' //addParams( sort_options: params.samtools_sort_options, index_options: params.samtools_index_options, stats_options: params.samtools_stats_options ) workflow FILTER_BAM_BAMTOOLS { take: diff --git a/subworkflows/local/input_check.nf b/subworkflows/local/input_check.nf index a20214b73..0879ae832 100644 --- a/subworkflows/local/input_check.nf +++ b/subworkflows/local/input_check.nf @@ -2,9 +2,7 @@ // Check input samplesheet and get read channels // -params.options = [:] - -include { SAMPLESHEET_CHECK } from '../../modules/local/samplesheet_check' addParams( options: params.options ) +include { SAMPLESHEET_CHECK } from '../../modules/local/samplesheet_check' workflow INPUT_CHECK { take: diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index 1e776669f..620bb87a8 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -2,24 +2,19 @@ // Uncompress and prepare reference genome files // -params.genome_options = [:] -params.index_options = [:] -params.gffread_options = [:] -params.bwa_index_options = [:] - include { GUNZIP as GUNZIP_FASTA GUNZIP as GUNZIP_GTF GUNZIP as GUNZIP_GFF GUNZIP as GUNZIP_GENE_BED - GUNZIP as GUNZIP_BLACKLIST } from '../../modules/nf-core/modules/gunzip/main' addParams( options: params.genome_options ) -include { UNTAR } from '../../modules/nf-core/modules/untar/main' addParams( options: params.index_options ) -include { GFFREAD } from '../../modules/nf-core/modules/gffread/main' addParams( options: params.gffread_options ) -include { BWA_INDEX } from '../../modules/nf-core/modules/bwa/index/main' addParams( options: params.bwa_index_options ) - -include { GTF2BED } from '../../modules/local/gtf2bed' addParams( options: params.genome_options ) -include { GET_CHROM_SIZES } from '../../modules/local/get_chrom_sizes' addParams( options: params.genome_options ) -include { GENOME_BLACKLIST_REGIONS } from '../../modules/local/genome_blacklist_regions' addParams( options: params.genome_options ) + GUNZIP as GUNZIP_BLACKLIST } from '../../modules/nf-core/modules/gunzip/main' +include { UNTAR } from '../../modules/nf-core/modules/untar/main' +include { GFFREAD } from '../../modules/nf-core/modules/gffread/main' +include { BWA_INDEX } from '../../modules/nf-core/modules/bwa/index/main' + +include { GTF2BED } from '../../modules/local/gtf2bed' +include { GET_CHROM_SIZES } from '../../modules/local/get_chrom_sizes' +include { GENOME_BLACKLIST_REGIONS } from '../../modules/local/genome_blacklist_regions' workflow PREPARE_GENOME { diff --git a/subworkflows/nf-core/align_bwa_mem.nf b/subworkflows/nf-core/align_bwa_mem.nf index 3d1c8a325..0f80487fa 100644 --- a/subworkflows/nf-core/align_bwa_mem.nf +++ b/subworkflows/nf-core/align_bwa_mem.nf @@ -2,13 +2,13 @@ * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats */ -params.bwa_mem_options = [:] -params.samtools_sort_options = [:] -params.samtools_index_options = [:] -params.samtools_stats_options = [:] +// params.bwa_mem_options = [:] +// params.samtools_sort_options = [:] +// params.samtools_index_options = [:] +// params.samtools_stats_options = [:] -include { BWA_MEM } from '../../modules/nf-core/modules/bwa/mem/main' addParams( options: params.bwa_mem_options ) -include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' addParams( sort_options: params.samtools_sort_options, index_options: params.samtools_index_options, stats_options: params.samtools_stats_options ) +include { BWA_MEM } from '../../modules/nf-core/modules/bwa/mem/main' //addParams( options: params.bwa_mem_options ) +include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' //addParams( sort_options: params.samtools_sort_options, index_options: params.samtools_index_options, stats_options: params.samtools_stats_options ) workflow ALIGN_BWA_MEM { take: diff --git a/subworkflows/nf-core/bam_sort_samtools.nf b/subworkflows/nf-core/bam_sort_samtools.nf index 53148682a..9e1ce9dbb 100644 --- a/subworkflows/nf-core/bam_sort_samtools.nf +++ b/subworkflows/nf-core/bam_sort_samtools.nf @@ -2,13 +2,13 @@ * Sort, index BAM file and run samtools stats, flagstat and idxstats */ -params.sort_options = [:] -params.index_options = [:] -params.stats_options = [:] +// params.sort_options = [:] +// params.index_options = [:] +// params.stats_options = [:] -include { SAMTOOLS_SORT } from '../../modules/nf-core/modules/samtools/sort/main' addParams( options: params.sort_options ) -include { SAMTOOLS_INDEX } from '../../modules/nf-core/modules/samtools/index/main' addParams( options: params.index_options ) -include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' addParams( options: params.stats_options ) +include { SAMTOOLS_SORT } from '../../modules/nf-core/modules/samtools/sort/main' //addParams( options: params.sort_options ) +include { SAMTOOLS_INDEX } from '../../modules/nf-core/modules/samtools/index/main' //addParams( options: params.index_options ) +include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' //addParams( options: params.stats_options ) workflow BAM_SORT_SAMTOOLS { take: diff --git a/subworkflows/nf-core/bam_stats_samtools.nf b/subworkflows/nf-core/bam_stats_samtools.nf index 5307c239c..fe26629a6 100644 --- a/subworkflows/nf-core/bam_stats_samtools.nf +++ b/subworkflows/nf-core/bam_stats_samtools.nf @@ -2,11 +2,11 @@ * Run SAMtools stats, flagstat and idxstats */ -params.options = [:] +//params.options = [:] -include { SAMTOOLS_STATS } from '../../modules/nf-core/modules/samtools/stats/main' addParams( options: params.options ) -include { SAMTOOLS_IDXSTATS } from '../../modules/nf-core/modules/samtools/idxstats/main' addParams( options: params.options ) -include { SAMTOOLS_FLAGSTAT } from '../../modules/nf-core/modules/samtools/flagstat/main' addParams( options: params.options ) +include { SAMTOOLS_STATS } from '../../modules/nf-core/modules/samtools/stats/main' //addParams( options: params.options ) +include { SAMTOOLS_IDXSTATS } from '../../modules/nf-core/modules/samtools/idxstats/main' //addParams( options: params.options ) +include { SAMTOOLS_FLAGSTAT } from '../../modules/nf-core/modules/samtools/flagstat/main' //addParams( options: params.options ) workflow BAM_STATS_SAMTOOLS { take: @@ -16,7 +16,7 @@ workflow BAM_STATS_SAMTOOLS { ch_versions = Channel.empty() - SAMTOOLS_STATS ( ch_bam_bai ) + SAMTOOLS_STATS ( ch_bam_bai, [] ) ch_versions = ch_versions.mix(SAMTOOLS_STATS.out.versions.first()) SAMTOOLS_FLAGSTAT ( ch_bam_bai ) diff --git a/subworkflows/nf-core/mark_duplicates_picard.nf b/subworkflows/nf-core/mark_duplicates_picard.nf index af2a944e5..adaa2911a 100644 --- a/subworkflows/nf-core/mark_duplicates_picard.nf +++ b/subworkflows/nf-core/mark_duplicates_picard.nf @@ -1,13 +1,13 @@ /* * Picard MarkDuplicates, sort, index BAM file and run samtools stats, flagstat and idxstats */ -params.markduplicates_options = [:] -params.samtools_index_options = [:] -params.samtools_stats_options = [:] +// params.markduplicates_options = [:] // TODO +// params.samtools_index_options = [:] // TODO +// params.samtools_stats_options = [:] // TODO -include { PICARD_MARKDUPLICATES } from '../../modules/nf-core/modules/picard/markduplicates/main' addParams( options: params.markduplicates_options ) -include { SAMTOOLS_INDEX } from '../../modules/nf-core/modules/samtools/index/main' addParams( options: params.samtools_index_options ) -include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' addParams( options: params.samtools_stats_options ) +include { PICARD_MARKDUPLICATES } from '../../modules/nf-core/modules/picard/markduplicates/main' //addParams( options: params.markduplicates_options ) +include { SAMTOOLS_INDEX } from '../../modules/nf-core/modules/samtools/index/main' //addParams( options: params.samtools_index_options ) +include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' //addParams( options: params.samtools_stats_options ) workflow MARK_DUPLICATES_PICARD { take: diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 1a9e4e7df..9e3833020 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -27,7 +27,7 @@ if (anno_readme && file(anno_readme).exists()) { file(anno_readme).copyTo("${params.outdir}/genome/") } -def peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' +// def peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' /* ======================================================================================== @@ -59,59 +59,59 @@ ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering */ // Don't overwrite global params.modules, create a copy instead and use that within the main script. -def modules = params.modules.clone() +// def modules = params.modules.clone() -def plot_macs2_qc_options = modules['plot_macs2_qc'] -plot_macs2_qc_options.publish_dir += "/$peakType/qc" +// def plot_macs2_qc_options = modules['plot_macs2_qc'] +// plot_macs2_qc_options.publish_dir += "/$peakType/qc" -def plot_homer_annotatepeaks_options = modules['plot_homer_annotatepeaks'] -plot_homer_annotatepeaks_options.publish_dir += "/$peakType/qc" +// def plot_homer_annotatepeaks_options = modules['plot_homer_annotatepeaks'] +// plot_homer_annotatepeaks_options.publish_dir += "/$peakType/qc" -def macs2_consensus_options = modules['macs2_consensus'] -macs2_consensus_options.publish_dir += "/$peakType/qc" +// def macs2_consensus_options = modules['macs2_consensus'] +// macs2_consensus_options.publish_dir += "/$peakType/qc" -def multiqc_options = modules['multiqc'] -multiqc_options.args += params.multiqc_title ? Utils.joinModuleArgs(["--title \"$params.multiqc_title\""]) : '' -multiqc_options.publish_dir += "/$peakType" +// def multiqc_options = modules['multiqc'] +// multiqc_options.args += params.multiqc_title ? Utils.joinModuleArgs(["--title \"$params.multiqc_title\""]) : '' +// multiqc_options.publish_dir += "/$peakType" -include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_genomecov' addParams( options: modules['bedtools_genomecov'] ) -include { FRIP_SCORE } from '../modules/local/frip_score' addParams( options: modules['frip_score'] ) -include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' addParams( options: plot_macs2_qc_options ) -include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' addParams( options: plot_homer_annotatepeaks_options ) -include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' addParams( options: macs2_consensus_options ) -//include { DESEQ2_QC } from '../modules/local/deseq2_qc' addParams( options: deseq2_qc_options, multiqc_label: 'star_salmon' ) -include { IGV } from '../modules/local/igv' addParams( options: [:] ) -include { MULTIQC } from '../modules/local/multiqc' addParams( options: multiqc_options ) -include { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS } from '../modules/local/multiqc_custom_phantompeakqualtools' addParams( options: modules['multiqc_custom_phantompeakqualtools'] ) -include { MULTIQC_CUSTOM_PEAKS } from '../modules/local/multiqc_custom_peaks' addParams( options: modules['multiqc_custom_peaks'] ) +include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_genomecov' +include { FRIP_SCORE } from '../modules/local/frip_score' +include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' +include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' +include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' +//include { DESEQ2_QC } from '../modules/local/deseq2_qc' +include { IGV } from '../modules/local/igv' //addParams( options: [:] ) +include { MULTIQC } from '../modules/local/multiqc' +include { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS } from '../modules/local/multiqc_custom_phantompeakqualtools' +include { MULTIQC_CUSTOM_PEAKS } from '../modules/local/multiqc_custom_peaks' // // SUBWORKFLOW: Consisting of a mix of local and nf-core/modules // -def publish_genome_options = params.save_reference ? [publish_dir: 'genome'] : [publish_files: false] -def publish_index_options = params.save_reference ? [publish_dir: 'genome/index'] : [publish_files: false] - -def gffread_options = modules['gffread'] -if (!params.save_reference) { gffread_options['publish_files'] = false } - -def bwa_index_options = modules['bwa_index'] -if (!params.save_reference) { bwa_index_options['publish_files'] = false } - -include { INPUT_CHECK } from '../subworkflows/local/input_check' addParams( options: [:] ) -include { PREPARE_GENOME } from '../subworkflows/local/prepare_genome' addParams( - genome_options : publish_genome_options, - index_options : publish_index_options, - gffread_options : gffread_options, - bwa_index_options : bwa_index_options -) -include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' addParams( - bam_filter_options : modules['bam_filter'], - bam_remove_orphans_options: modules['bam_remove_orphans'], - samtools_sort_options : modules['samtools_sort_filter'], - samtools_index_options : modules['samtools_sort_filter'], - samtools_stats_options : modules['samtools_sort_filter'] -) +// def publish_genome_options = params.save_reference ? [publish_dir: 'genome'] : [publish_files: false] +// def publish_index_options = params.save_reference ? [publish_dir: 'genome/index'] : [publish_files: false] + +// def gffread_options = modules['gffread'] +// if (!params.save_reference) { gffread_options['publish_files'] = false } + +// def bwa_index_options = modules['bwa_index'] +// if (!params.save_reference) { bwa_index_options['publish_files'] = false } + +include { INPUT_CHECK } from '../subworkflows/local/input_check' //addParams( options: [:] ) +include { PREPARE_GENOME } from '../subworkflows/local/prepare_genome' //addParams( +// genome_options : publish_genome_options, +// index_options : publish_index_options, +// gffread_options : gffread_options, +// bwa_index_options : bwa_index_options +// ) +include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' //addParams( +// bam_filter_options : modules['bam_filter'], +// bam_remove_orphans_options: modules['bam_remove_orphans'], +// samtools_sort_options : modules['samtools_sort_filter'], +// samtools_index_options : modules['samtools_sort_filter'], +// samtools_stats_options : modules['samtools_sort_filter'] +// ) /* ======================================================================================== @@ -123,55 +123,55 @@ include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' // MODULE: Installed directly from nf-core/modules // -def deeptools_plotfingerprint_options = modules['deeptools_plotfingerprint'] -deeptools_plotfingerprint_options.args += " --numberOfSamples $params.fingerprint_bins" - -def macs2_callpeak_options = modules['macs2_callpeak'] -macs2_callpeak_options.args += params.narrow_peak ? '' : Utils.joinModuleArgs(['--broad', "--broad-cutoff ${params.broad_cutoff}"]) -macs2_callpeak_options.args += params.save_macs_pileup ? Utils.joinModuleArgs(['--bdg', '--SPMR']) : '' -macs2_callpeak_options.args += params.macs_fdr ? Utils.joinModuleArgs(["--qvalue ${params.macs_fdr}"]) : '' -macs2_callpeak_options.args += params.macs_pvalue ? Utils.joinModuleArgs(["--pvalue ${params.macs_pvalue}"]) : '' -macs2_callpeak_options['publish_dir'] += "/$peakType" - -def homer_annotatepeaks_macs2_options = modules['homer_annotatepeaks_macs2'] -homer_annotatepeaks_macs2_options['publish_dir'] += "/$peakType" - -def homer_annotatepeaks_consensus_options = modules['homer_annotatepeaks_consensus'] -homer_annotatepeaks_consensus_options['publish_dir'] += "/$peakType/consensus" - -def subread_featurecounts_options = modules['subread_featurecounts'] -subread_featurecounts_options['publish_dir'] += "/$peakType/consensus" - -include { PICARD_MERGESAMFILES } from '../modules/nf-core/modules/picard/mergesamfiles/main' addParams( options: modules['picard_mergesamfiles'] ) -include { PICARD_COLLECTMULTIPLEMETRICS } from '../modules/nf-core/modules/picard/collectmultiplemetrics/main' addParams( options: modules['picard_collectmultiplemetrics'] ) -include { PRESEQ_LCEXTRAP } from '../modules/nf-core/modules/preseq/lcextrap/main' addParams( options: modules['preseq_lcextrap'] ) -include { PHANTOMPEAKQUALTOOLS } from '../modules/nf-core/modules/phantompeakqualtools/main' addParams( options: modules['phantompeakqualtools'] ) -include { UCSC_BEDGRAPHTOBIGWIG } from '../modules/nf-core/modules/ucsc/bedgraphtobigwig/main' addParams( options: modules['ucsc_bedgraphtobigwig'] ) -include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/modules/deeptools/computematrix/main' addParams( options: modules['deeptools_computematrix'] ) -include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/modules/deeptools/plotprofile/main' addParams( options: modules['deeptools_plotprofile'] ) -include { DEEPTOOLS_PLOTHEATMAP } from '../modules/nf-core/modules/deeptools/plotheatmap/main' addParams( options: modules['deeptools_plotheatmap'] ) -include { DEEPTOOLS_PLOTFINGERPRINT } from '../modules/nf-core/modules/deeptools/plotfingerprint/main' addParams( options: deeptools_plotfingerprint_options ) -include { MACS2_CALLPEAK } from '../modules/nf-core/modules/macs2/callpeak/main' addParams( options: macs2_callpeak_options ) -include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/modules/subread/featurecounts/main' addParams( options: subread_featurecounts_options ) -include { CUSTOM_DUMPSOFTWAREVERSIONS } from '../modules/nf-core/modules/custom/dumpsoftwareversions/main' addParams( options: [publish_files : ['_versions.yml':'']] ) - -include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_macs2_options ) -include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../modules/nf-core/modules/homer/annotatepeaks/main' addParams( options:homer_annotatepeaks_consensus_options ) +// def deeptools_plotfingerprint_options = modules['deeptools_plotfingerprint'] // AQUI see here https://github.com/nf-core/rnaseq/blob/492f6e0e678b4a5fcdf26b3a60834efb23265889/conf/modules.config#L83 +// deeptools_plotfingerprint_options.args += " --numberOfSamples $params.fingerprint_bins" + +// def macs2_callpeak_options = modules['macs2_callpeak'] +// macs2_callpeak_options.args += params.narrow_peak ? '' : Utils.joinModuleArgs(['--broad', "--broad-cutoff ${params.broad_cutoff}"]) +// macs2_callpeak_options.args += params.save_macs_pileup ? Utils.joinModuleArgs(['--bdg', '--SPMR']) : '' +// macs2_callpeak_options.args += params.macs_fdr ? Utils.joinModuleArgs(["--qvalue ${params.macs_fdr}"]) : '' +// macs2_callpeak_options.args += params.macs_pvalue ? Utils.joinModuleArgs(["--pvalue ${params.macs_pvalue}"]) : '' +// macs2_callpeak_options['publish_dir'] += "/$peakType" + +// def homer_annotatepeaks_macs2_options = modules['homer_annotatepeaks_macs2'] +// homer_annotatepeaks_macs2_options['publish_dir'] += "/$peakType" + +// def homer_annotatepeaks_consensus_options = modules['homer_annotatepeaks_consensus'] +// homer_annotatepeaks_consensus_options['publish_dir'] += "/$peakType/consensus" + +// def subread_featurecounts_options = modules['subread_featurecounts'] +// subread_featurecounts_options['publish_dir'] += "/$peakType/consensus" + +include { PICARD_MERGESAMFILES } from '../modules/nf-core/modules/picard/mergesamfiles/main' +include { PICARD_COLLECTMULTIPLEMETRICS } from '../modules/nf-core/modules/picard/collectmultiplemetrics/main' +include { PRESEQ_LCEXTRAP } from '../modules/nf-core/modules/preseq/lcextrap/main' +include { PHANTOMPEAKQUALTOOLS } from '../modules/nf-core/modules/phantompeakqualtools/main' +include { UCSC_BEDGRAPHTOBIGWIG } from '../modules/nf-core/modules/ucsc/bedgraphtobigwig/main' +include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/modules/deeptools/computematrix/main' +include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/modules/deeptools/plotprofile/main' +include { DEEPTOOLS_PLOTHEATMAP } from '../modules/nf-core/modules/deeptools/plotheatmap/main' +include { DEEPTOOLS_PLOTFINGERPRINT } from '../modules/nf-core/modules/deeptools/plotfingerprint/main' +include { MACS2_CALLPEAK } from '../modules/nf-core/modules/macs2/callpeak/main' +include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/modules/subread/featurecounts/main' +include { CUSTOM_DUMPSOFTWAREVERSIONS } from '../modules/nf-core/modules/custom/dumpsoftwareversions/main' + +include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_MACS2 } from '../modules/nf-core/modules/homer/annotatepeaks/main' +include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../modules/nf-core/modules/homer/annotatepeaks/main' // // SUBWORKFLOW: Consisting entirely of nf-core/modules // -def trimgalore_options = modules['trimgalore'] -trimgalore_options.args += params.trim_nextseq > 0 ? Utils.joinModuleArgs(["--nextseq ${params.trim_nextseq}"]) : '' -if (params.save_trimmed) { trimgalore_options.publish_files.put('fq.gz','') } +// def trimgalore_options = modules['trimgalore'] +// trimgalore_options.args += params.trim_nextseq > 0 ? Utils.joinModuleArgs(["--nextseq ${params.trim_nextseq}"]) : '' +// if (params.save_trimmed) { trimgalore_options.publish_files.put('fq.gz','') } -def picard_markduplicates_samtools = modules['picard_markduplicates_samtools'] +// def picard_markduplicates_samtools = modules['picard_markduplicates_samtools'] -include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' addParams( fastqc_options: modules['fastqc'], trimgalore_options: trimgalore_options ) -include { ALIGN_BWA_MEM } from '../subworkflows/nf-core/align_bwa_mem' addParams( bwa_mem_options: modules['bwa_mem'], samtools_sort_options: modules['samtools_sort_lib'], samtools_index_options: modules['samtools_sort_lib'], samtools_stats_options: modules['samtools_sort_lib'] ) -include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' addParams( markduplicates_options: modules['picard_markduplicates'], samtools_index_options: picard_markduplicates_samtools, samtools_stats_options: picard_markduplicates_samtools ) +include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' //addParams( fastqc_options: modules['fastqc'], trimgalore_options: trimgalore_options ) +include { ALIGN_BWA_MEM } from '../subworkflows/nf-core/align_bwa_mem' //addParams( bwa_mem_options: modules['bwa_mem'], samtools_sort_options: modules['samtools_sort_lib'], samtools_index_options: modules['samtools_sort_lib'], samtools_stats_options: modules['samtools_sort_lib'] ) +include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' //addParams( markduplicates_options: modules['picard_markduplicates'], samtools_index_options: picard_markduplicates_samtools, samtools_stats_options: picard_markduplicates_samtools ) /* ======================================================================================== @@ -214,8 +214,9 @@ workflow CHIPSEQ { // // SUBWORKFLOW: Map reads & BAM QC // - score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' - params.modules['bwa_mem'].args += score + // score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' + // params.modules['bwa_mem'].args += score + ALIGN_BWA_MEM ( FASTQC_TRIMGALORE.out.reads, PREPARE_GENOME.out.bwa_index @@ -410,6 +411,8 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first()) + // HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}.view() + PLOT_HOMER_ANNOTATEPEAKS ( HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, ch_peak_annotation_header, @@ -488,16 +491,17 @@ workflow CHIPSEQ { // // Create IGV session // - IGV ( - PREPARE_GENOME.out.fasta, - UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), - MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), - MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), - params.modules['ucsc_bedgraphtobigwig'], - params.modules['macs2_callpeak'], - params.modules['macs2_consensus'] - ) - ch_versions = ch_versions.mix(IGV.out.versions) + // TODO rethink how files are passed + // IGV ( + // PREPARE_GENOME.out.fasta, + // UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), + // MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), + // MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), + // params.modules['ucsc_bedgraphtobigwig'], + // params.modules['macs2_callpeak'], + // params.modules['macs2_consensus'] + // ) + // ch_versions = ch_versions.mix(IGV.out.versions) // // MODULE: Pipeline reporting From 9b2c1220e125446f39b78302c0fb4fd3b4ca916d Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 13 Dec 2021 23:19:24 +0100 Subject: [PATCH 255/538] Fix indent --- conf/modules.config | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index cc86eff03..af9af4b4b 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -55,7 +55,7 @@ process { enabled: params.save_reference ] } - withName: BWA_INDEX { + withName: BWA_INDEX { ext.args = '-a bwtsw' publishDir = [ path: { "${params.outdir}/genome/index" }, From 9733d26356d8d21331488f5479775021a9985d90 Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Tue, 14 Dec 2021 16:42:47 +0000 Subject: [PATCH 256/538] Template update for nf-core/tools version 2.2 --- .gitattributes | 2 + .github/CONTRIBUTING.md | 38 ++------ .github/ISSUE_TEMPLATE/bug_report.md | 63 ------------- .github/ISSUE_TEMPLATE/bug_report.yml | 52 ++++++++++ .github/ISSUE_TEMPLATE/config.yml | 1 - .github/ISSUE_TEMPLATE/feature_request.md | 32 ------- .github/ISSUE_TEMPLATE/feature_request.yml | 11 +++ .github/workflows/awsfulltest.yml | 8 +- .github/workflows/awstest.yml | 10 +- .github/workflows/ci.yml | 23 +++-- .github/workflows/linting_comment.yml | 1 + CITATIONS.md | 2 +- README.md | 13 ++- assets/multiqc_config.yaml | 2 +- assets/nf-core-chipseq_logo.png | Bin 17874 -> 0 bytes assets/nf-core-chipseq_logo_light.png | Bin 0 -> 10959 bytes assets/sendmail_template.txt | 4 +- bin/scrape_software_versions.py | 36 ------- conf/base.config | 3 + conf/modules.config | 55 ++++++----- conf/test.config | 4 +- docs/images/nf-core-chipseq_logo.png | Bin 34565 -> 0 bytes docs/images/nf-core-chipseq_logo_dark.png | Bin 0 -> 73947 bytes docs/images/nf-core-chipseq_logo_light.png | 11 +++ docs/output.md | 2 +- docs/usage.md | 36 ------- lib/NfcoreSchema.groovy | 26 +++-- lib/NfcoreTemplate.groovy | 30 ++---- lib/Utils.groovy | 7 -- lib/WorkflowMain.groovy | 6 +- modules.json | 9 +- modules/local/functions.nf | 68 ------------- modules/local/get_software_versions.nf | 33 ------- modules/local/samplesheet_check.nf | 24 ++--- .../custom/dumpsoftwareversions/main.nf | 21 +++++ .../custom/dumpsoftwareversions/meta.yml | 34 +++++++ .../templates/dumpsoftwareversions.py | 89 ++++++++++++++++++ modules/nf-core/modules/fastqc/functions.nf | 68 ------------- modules/nf-core/modules/fastqc/main.nf | 39 ++++---- modules/nf-core/modules/fastqc/meta.yml | 7 +- modules/nf-core/modules/multiqc/functions.nf | 68 ------------- modules/nf-core/modules/multiqc/main.nf | 31 +++--- modules/nf-core/modules/multiqc/meta.yml | 7 +- nextflow.config | 31 +++--- nextflow_schema.json | 29 ------ subworkflows/local/input_check.nf | 8 +- workflows/chipseq.nf | 44 +++------ 47 files changed, 419 insertions(+), 669 deletions(-) delete mode 100644 .github/ISSUE_TEMPLATE/bug_report.md create mode 100644 .github/ISSUE_TEMPLATE/bug_report.yml delete mode 100644 .github/ISSUE_TEMPLATE/feature_request.md create mode 100644 .github/ISSUE_TEMPLATE/feature_request.yml delete mode 100644 assets/nf-core-chipseq_logo.png create mode 100644 assets/nf-core-chipseq_logo_light.png delete mode 100755 bin/scrape_software_versions.py delete mode 100644 docs/images/nf-core-chipseq_logo.png create mode 100644 docs/images/nf-core-chipseq_logo_dark.png create mode 100644 docs/images/nf-core-chipseq_logo_light.png delete mode 100644 modules/local/functions.nf delete mode 100644 modules/local/get_software_versions.nf create mode 100644 modules/nf-core/modules/custom/dumpsoftwareversions/main.nf create mode 100644 modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml create mode 100644 modules/nf-core/modules/custom/dumpsoftwareversions/templates/dumpsoftwareversions.py delete mode 100644 modules/nf-core/modules/fastqc/functions.nf delete mode 100644 modules/nf-core/modules/multiqc/functions.nf diff --git a/.gitattributes b/.gitattributes index 7fe55006f..050bb1203 100644 --- a/.gitattributes +++ b/.gitattributes @@ -1 +1,3 @@ *.config linguist-language=nextflow +modules/nf-core/** linguist-generated +subworkflows/nf-core/** linguist-generated diff --git a/.github/CONTRIBUTING.md b/.github/CONTRIBUTING.md index 87854ad80..d37fb5dfa 100644 --- a/.github/CONTRIBUTING.md +++ b/.github/CONTRIBUTING.md @@ -68,16 +68,13 @@ If you wish to contribute a new step, please use the following coding standards: 1. Define the corresponding input channel into your new process from the expected previous process channel 2. Write the process block (see below). 3. Define the output channel if needed (see below). -4. Add any new flags/options to `nextflow.config` with a default (see below). -5. Add any new flags/options to `nextflow_schema.json` with help text (with `nf-core schema build`). -6. Add any new flags/options to the help message (for integer/text parameters, print to help the corresponding `nextflow.config` parameter). -7. Add sanity checks for all relevant parameters. -8. Add any new software to the `scrape_software_versions.py` script in `bin/` and the version command to the `scrape_software_versions` process in `main.nf`. -9. Do local tests that the new code works properly and as expected. -10. Add a new test command in `.github/workflow/ci.yml`. -11. If applicable add a [MultiQC](https://https://multiqc.info/) module. -12. Update MultiQC config `assets/multiqc_config.yaml` so relevant suffixes, name clean up, General Statistics Table column order, and module figures are in the right order. -13. Optional: Add any descriptions of MultiQC report sections and output files to `docs/output.md`. +4. Add any new parameters to `nextflow.config` with a default (see below). +5. Add any new parameters to `nextflow_schema.json` with help text (via the `nf-core schema build` tool). +6. Add sanity checks and validation for all relevant parameters. +7. Perform local tests to validate that the new code works as expected. +8. If applicable, add a new test command in `.github/workflow/ci.yml`. +9. Update MultiQC config `assets/multiqc_config.yaml` so relevant suffixes, file name clean up and module plots are in the appropriate order. If applicable, add a [MultiQC](https://https://multiqc.info/) module. +10. Add a description of the output files and if relevant any appropriate images from the MultiQC report to `docs/output.md`. ### Default values @@ -102,27 +99,6 @@ Please use the following naming schemes, to make it easy to understand what is g If you are using a new feature from core Nextflow, you may bump the minimum required version of nextflow in the pipeline with: `nf-core bump-version --nextflow . [min-nf-version]` -### Software version reporting - -If you add a new tool to the pipeline, please ensure you add the information of the tool to the `get_software_version` process. - -Add to the script block of the process, something like the following: - -```bash - --version &> v_.txt 2>&1 || true -``` - -or - -```bash - --help | head -n 1 &> v_.txt 2>&1 || true -``` - -You then need to edit the script `bin/scrape_software_versions.py` to: - -1. Add a Python regex for your tool's `--version` output (as in stored in the `v_.txt` file), to ensure the version is reported as a `v` and the version number e.g. `v2.1.1` -2. Add a HTML entry to the `OrderedDict` for formatting in MultiQC. - ### Images and figures For overview images and other documents we follow the nf-core [style guidelines and examples](https://nf-co.re/developers/design_guidelines). diff --git a/.github/ISSUE_TEMPLATE/bug_report.md b/.github/ISSUE_TEMPLATE/bug_report.md deleted file mode 100644 index dbc527cc8..000000000 --- a/.github/ISSUE_TEMPLATE/bug_report.md +++ /dev/null @@ -1,63 +0,0 @@ ---- -name: Bug report -about: Report something that is broken or incorrect -labels: bug ---- - - - -## Check Documentation - -I have checked the following places for your error: - -- [ ] [nf-core website: troubleshooting](https://nf-co.re/usage/troubleshooting) -- [ ] [nf-core/chipseq pipeline documentation](https://nf-co.re/chipseq/usage) - -## Description of the bug - - - -## Steps to reproduce - -Steps to reproduce the behaviour: - -1. Command line: -2. See error: - -## Expected behaviour - - - -## Log files - -Have you provided the following extra information/files: - -- [ ] The command used to run the pipeline -- [ ] The `.nextflow.log` file - -## System - -- Hardware: -- Executor: -- OS: -- Version - -## Nextflow Installation - -- Version: - -## Container engine - -- Engine: -- version: - -## Additional context - - diff --git a/.github/ISSUE_TEMPLATE/bug_report.yml b/.github/ISSUE_TEMPLATE/bug_report.yml new file mode 100644 index 000000000..b0d2788d9 --- /dev/null +++ b/.github/ISSUE_TEMPLATE/bug_report.yml @@ -0,0 +1,52 @@ + +name: Bug report +description: Report something that is broken or incorrect +labels: bug +body: + + - type: markdown + attributes: + value: | + Before you post this issue, please check the documentation: + + - [nf-core website: troubleshooting](https://nf-co.re/usage/troubleshooting) + - [nf-core/chipseq pipeline documentation](https://nf-co.re/chipseq/usage) + + - type: textarea + id: description + attributes: + label: Description of the bug + description: A clear and concise description of what the bug is. + validations: + required: true + + - type: textarea + id: command_used + attributes: + label: Command used and terminal output + description: Steps to reproduce the behaviour. Please paste the command you used to launch the pipeline and the output from your terminal. + render: console + placeholder: | + $ nextflow run ... + + Some output where something broke + + - type: textarea + id: files + attributes: + label: Relevant files + description: | + Please drag and drop the relevant files here. Create a `.zip` archive if the extension is not allowed. + Your verbose log file `.nextflow.log` is often useful _(this is a hidden file in the directory where you launched the pipeline)_ as well as custom Nextflow configuration files. + + - type: textarea + id: system + attributes: + label: System information + description: | + * Nextflow version _(eg. 21.10.3)_ + * Hardware _(eg. HPC, Desktop, Cloud)_ + * Executor _(eg. slurm, local, awsbatch)_ + * Container engine: _(e.g. Docker, Singularity, Conda, Podman, Shifter or Charliecloud)_ + * OS _(eg. CentOS Linux, macOS, Linux Mint)_ + * Version of nf-core/chipseq _(eg. 1.1, 1.5, 1.8.2)_ diff --git a/.github/ISSUE_TEMPLATE/config.yml b/.github/ISSUE_TEMPLATE/config.yml index 6b4360344..997624c21 100644 --- a/.github/ISSUE_TEMPLATE/config.yml +++ b/.github/ISSUE_TEMPLATE/config.yml @@ -1,4 +1,3 @@ -blank_issues_enabled: false contact_links: - name: Join nf-core url: https://nf-co.re/join diff --git a/.github/ISSUE_TEMPLATE/feature_request.md b/.github/ISSUE_TEMPLATE/feature_request.md deleted file mode 100644 index 15aceab96..000000000 --- a/.github/ISSUE_TEMPLATE/feature_request.md +++ /dev/null @@ -1,32 +0,0 @@ ---- -name: Feature request -about: Suggest an idea for the nf-core/chipseq pipeline -labels: enhancement ---- - - - -## Is your feature request related to a problem? Please describe - - - - - -## Describe the solution you'd like - - - -## Describe alternatives you've considered - - - -## Additional context - - diff --git a/.github/ISSUE_TEMPLATE/feature_request.yml b/.github/ISSUE_TEMPLATE/feature_request.yml new file mode 100644 index 000000000..d8c130a54 --- /dev/null +++ b/.github/ISSUE_TEMPLATE/feature_request.yml @@ -0,0 +1,11 @@ +name: Feature request +description: Suggest an idea for the nf-core/chipseq pipeline +labels: enhancement +body: + - type: textarea + id: description + attributes: + label: Description of feature + description: Please describe your suggestion for a new feature. It might help to describe a problem or use case, plus any alternatives that you have considered. + validations: + required: true diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index 906aa559c..a5e2cade9 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -14,14 +14,14 @@ jobs: runs-on: ubuntu-latest steps: - name: Launch workflow via tower - uses: nf-core/tower-action@master + uses: nf-core/tower-action@v2 # TODO nf-core: You can customise AWS full pipeline tests as required # Add full size test data (but still relatively small datasets for few samples) # on the `test_full.config` test runs with only one set of parameters with: workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }} - bearer_token: ${{ secrets.TOWER_BEARER_TOKEN }} + access_token: ${{ secrets.TOWER_ACCESS_TOKEN }} compute_env: ${{ secrets.TOWER_COMPUTE_ENV }} pipeline: ${{ github.repository }} revision: ${{ github.sha }} @@ -30,5 +30,5 @@ jobs: { "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-${{ github.sha }}" } - profiles: '[ "test_full", "aws_tower" ]' - + profiles: test_full,aws_tower + pre_run_script: 'export NXF_VER=21.10.3' diff --git a/.github/workflows/awstest.yml b/.github/workflows/awstest.yml index 6fc417220..b8f720cbe 100644 --- a/.github/workflows/awstest.yml +++ b/.github/workflows/awstest.yml @@ -11,18 +11,18 @@ jobs: runs-on: ubuntu-latest steps: - name: Launch workflow via tower - uses: nf-core/tower-action@master + uses: nf-core/tower-action@v2 with: workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }} - bearer_token: ${{ secrets.TOWER_BEARER_TOKEN }} + access_token: ${{ secrets.TOWER_ACCESS_TOKEN }} compute_env: ${{ secrets.TOWER_COMPUTE_ENV }} pipeline: ${{ github.repository }} revision: ${{ github.sha }} workdir: s3://${{ secrets.AWS_S3_BUCKET }}/work/chipseq/work-${{ github.sha }} parameters: | { - "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-${{ github.sha }}" + "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-test-${{ github.sha }}" } - profiles: '[ "test", "aws_tower" ]' - + profiles: test,aws_tower + pre_run_script: 'export NXF_VER=21.10.3' diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 1e8f2eba4..57b49cfac 100644 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -8,8 +8,9 @@ on: release: types: [published] -# Uncomment if we need an edge release of Nextflow again -# env: NXF_EDGE: 1 +env: + NXF_ANSI_LOG: false + CAPSULE_LOG: none jobs: test: @@ -17,20 +18,26 @@ jobs: # Only run on push if this is the nf-core dev branch (merged PRs) if: ${{ github.event_name != 'push' || (github.event_name == 'push' && github.repository == 'nf-core/chipseq') }} runs-on: ubuntu-latest - env: - NXF_VER: ${{ matrix.nxf_ver }} - NXF_ANSI_LOG: false strategy: matrix: - # Nextflow versions: check pipeline minimum and current latest - nxf_ver: ['21.04.0', ''] + # Nextflow versions + include: + # Test pipeline minimum Nextflow version + - NXF_VER: '21.10.3' + NXF_EDGE: '' + # Test latest edge release of Nextflow + - NXF_VER: '' + NXF_EDGE: '1' steps: - name: Check out pipeline code uses: actions/checkout@v2 - name: Install Nextflow env: - CAPSULE_LOG: none + NXF_VER: ${{ matrix.NXF_VER }} + # Uncomment only if the edge release is more recent than the latest stable release + # See https://github.com/nextflow-io/nextflow/issues/2467 + # NXF_EDGE: ${{ matrix.NXF_EDGE }} run: | wget -qO- get.nextflow.io | bash sudo mv nextflow /usr/local/bin/ diff --git a/.github/workflows/linting_comment.yml b/.github/workflows/linting_comment.yml index 90f03c6f9..44d72994b 100644 --- a/.github/workflows/linting_comment.yml +++ b/.github/workflows/linting_comment.yml @@ -15,6 +15,7 @@ jobs: uses: dawidd6/action-download-artifact@v2 with: workflow: linting.yml + workflow_conclusion: completed - name: Get PR number id: pr_number diff --git a/CITATIONS.md b/CITATIONS.md index 89046a380..cecb5945f 100644 --- a/CITATIONS.md +++ b/CITATIONS.md @@ -12,7 +12,7 @@ * [FastQC](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/) -* [MultiQC](https://www.ncbi.nlm.nih.gov/pubmed/27312411/) +* [MultiQC](https://pubmed.ncbi.nlm.nih.gov/27312411/) > Ewels P, Magnusson M, Lundin S, Käller M. MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics. 2016 Oct 1;32(19):3047-8. doi: 10.1093/bioinformatics/btw354. Epub 2016 Jun 16. PubMed PMID: 27312411; PubMed Central PMCID: PMC5039924. ## Software packaging/containerisation tools diff --git a/README.md b/README.md index 72f3bfd11..5dcdd654d 100644 --- a/README.md +++ b/README.md @@ -1,11 +1,11 @@ -# ![nf-core/chipseq](docs/images/nf-core-chipseq_logo.png) +# ![nf-core/chipseq](docs/images/nf-core-chipseq_logo_light.png#gh-light-mode-only) ![nf-core/chipseq](docs/images/nf-core-chipseq_logo_dark.png#gh-dark-mode-only) [![GitHub Actions CI Status](https://github.com/nf-core/chipseq/workflows/nf-core%20CI/badge.svg)](https://github.com/nf-core/chipseq/actions?query=workflow%3A%22nf-core+CI%22) [![GitHub Actions Linting Status](https://github.com/nf-core/chipseq/workflows/nf-core%20linting/badge.svg)](https://github.com/nf-core/chipseq/actions?query=workflow%3A%22nf-core+linting%22) [![AWS CI](https://img.shields.io/badge/CI%20tests-full%20size-FF9900?labelColor=000000&logo=Amazon%20AWS)](https://nf-co.re/chipseq/results) [![Cite with Zenodo](http://img.shields.io/badge/DOI-10.5281/zenodo.XXXXXXX-1073c8?labelColor=000000)](https://doi.org/10.5281/zenodo.XXXXXXX) -[![Nextflow](https://img.shields.io/badge/nextflow%20DSL2-%E2%89%A521.04.0-23aa62.svg?labelColor=000000)](https://www.nextflow.io/) +[![Nextflow](https://img.shields.io/badge/nextflow%20DSL2-%E2%89%A521.10.3-23aa62.svg?labelColor=000000)](https://www.nextflow.io/) [![run with conda](http://img.shields.io/badge/run%20with-conda-3EB049?labelColor=000000&logo=anaconda)](https://docs.conda.io/en/latest/) [![run with docker](https://img.shields.io/badge/run%20with-docker-0db7ed?labelColor=000000&logo=docker)](https://www.docker.com/) [![run with singularity](https://img.shields.io/badge/run%20with-singularity-1d355c.svg?labelColor=000000)](https://sylabs.io/docs/) @@ -33,18 +33,21 @@ On release, automated continuous integration tests run the pipeline on a full-si ## Quick Start -1. Install [`Nextflow`](https://www.nextflow.io/docs/latest/getstarted.html#installation) (`>=21.04.0`) +1. Install [`Nextflow`](https://www.nextflow.io/docs/latest/getstarted.html#installation) (`>=21.10.3`) 2. Install any of [`Docker`](https://docs.docker.com/engine/installation/), [`Singularity`](https://www.sylabs.io/guides/3.0/user-guide/), [`Podman`](https://podman.io/), [`Shifter`](https://nersc.gitlab.io/development/shifter/how-to-use/) or [`Charliecloud`](https://hpc.github.io/charliecloud/) for full pipeline reproducibility _(please only use [`Conda`](https://conda.io/miniconda.html) as a last resort; see [docs](https://nf-co.re/usage/configuration#basic-configuration-profiles))_ 3. Download the pipeline and test it on a minimal dataset with a single command: ```console - nextflow run nf-core/chipseq -profile test, + nextflow run nf-core/chipseq -profile test,YOURPROFILE ``` + Note that some form of configuration will be needed so that Nextflow knows how to fetch the required software. This is usually done in the form of a config profile (`YOURPROFILE` in the example command above). You can chain multiple config profiles in a comma-separated string. + + > * The pipeline comes with config profiles called `docker`, `singularity`, `podman`, `shifter`, `charliecloud` and `conda` which instruct the pipeline to use the named tool for software management. For example, `-profile test,docker`. > * Please check [nf-core/configs](https://github.com/nf-core/configs#documentation) to see if a custom config file to run nf-core pipelines already exists for your Institute. If so, you can simply use `-profile ` in your command. This will enable either `docker` or `singularity` and set the appropriate execution settings for your local compute environment. - > * If you are using `singularity` then the pipeline will auto-detect this and attempt to download the Singularity images directly as opposed to performing a conversion from Docker images. If you are persistently observing issues downloading Singularity images directly due to timeout or network issues then please use the `--singularity_pull_docker_container` parameter to pull and convert the Docker image instead. Alternatively, it is highly recommended to use the [`nf-core download`](https://nf-co.re/tools/#downloading-pipelines-for-offline-use) command to pre-download all of the required containers before running the pipeline and to set the [`NXF_SINGULARITY_CACHEDIR` or `singularity.cacheDir`](https://www.nextflow.io/docs/latest/singularity.html?#singularity-docker-hub) Nextflow options to be able to store and re-use the images from a central location for future pipeline runs. + > * If you are using `singularity` and are persistently observing issues downloading Singularity images directly due to timeout or network issues, then you can use the `--singularity_pull_docker_container` parameter to pull and convert the Docker image instead. Alternatively, you can use the [`nf-core download`](https://nf-co.re/tools/#downloading-pipelines-for-offline-use) command to download images first, before running the pipeline. Setting the [`NXF_SINGULARITY_CACHEDIR` or `singularity.cacheDir`](https://www.nextflow.io/docs/latest/singularity.html?#singularity-docker-hub) Nextflow options enables you to store and re-use the images from a central location for future pipeline runs. > * If you are using `conda`, it is highly recommended to use the [`NXF_CONDA_CACHEDIR` or `conda.cacheDir`](https://www.nextflow.io/docs/latest/conda.html) settings to store the environments in a central location for future pipeline runs. 4. Start running your own analysis! diff --git a/assets/multiqc_config.yaml b/assets/multiqc_config.yaml index bfe3a8f05..b7c276e1b 100644 --- a/assets/multiqc_config.yaml +++ b/assets/multiqc_config.yaml @@ -1,7 +1,7 @@ report_comment: > This report has been generated by the nf-core/chipseq analysis pipeline. 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zd}1j`?XN}KSYAwZB`&OgQ0(O=L+mqex-5l0SQ6MDNMYA%;gV|>6GI;0d$lc3#O8N) z@O@H#SHr7Sc92khCBaM}cU;e(%vr_J4eVv->980gkJj>Nc4J+)xE+!gSSYRi3^6 Fe*kd -Content-Disposition: inline; filename="nf-core-chipseq_logo.png" +Content-Disposition: inline; filename="nf-core-chipseq_logo_light.png" -<% out << new File("$projectDir/assets/nf-core-chipseq_logo.png"). +<% out << new File("$projectDir/assets/nf-core-chipseq_logo_light.png"). bytes. encodeBase64(). toString(). diff --git a/bin/scrape_software_versions.py b/bin/scrape_software_versions.py deleted file mode 100755 index c060d8d5d..000000000 --- a/bin/scrape_software_versions.py +++ /dev/null @@ -1,36 +0,0 @@ -#!/usr/bin/env python -from __future__ import print_function -import os - -results = {} -version_files = [x for x in os.listdir(".") if x.endswith(".version.txt")] -for version_file in version_files: - - software = version_file.replace(".version.txt", "") - if software == "pipeline": - software = "nf-core/chipseq" - - with open(version_file) as fin: - version = fin.read().strip() - results[software] = version - -# Dump to YAML -print( - """ -id: 'software_versions' -section_name: 'nf-core/chipseq Software Versions' -section_href: 'https://github.com/nf-core/chipseq' -plot_type: 'html' -description: 'are collected at run time from the software output.' -data: | -
-""" -) -for k, v in sorted(results.items()): - print("
{}
{}
".format(k, v)) -print("
") - -# Write out as tsv file: -with open("software_versions.tsv", "w") as f: - for k, v in sorted(results.items()): - f.write("{}\t{}\n".format(k, v)) diff --git a/conf/base.config b/conf/base.config index 467dd2fed..07779064b 100644 --- a/conf/base.config +++ b/conf/base.config @@ -54,4 +54,7 @@ process { errorStrategy = 'retry' maxRetries = 2 } + withName:CUSTOM_DUMPSOFTWAREVERSIONS { + cache = false + } } diff --git a/conf/modules.config b/conf/modules.config index 0b1bfdec2..a0506a4db 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -1,32 +1,41 @@ /* ======================================================================================== - Config file for defining DSL2 per module options + Config file for defining DSL2 per module options and publishing paths ======================================================================================== Available keys to override module options: - args = Additional arguments appended to command in module. - args2 = Second set of arguments appended to command in module (multi-tool modules). - args3 = Third set of arguments appended to command in module (multi-tool modules). - publish_dir = Directory to publish results. - publish_by_meta = Groovy list of keys available in meta map to append as directories to "publish_dir" path - If publish_by_meta = true - Value of ${meta['id']} is appended as a directory to "publish_dir" path - If publish_by_meta = ['id', 'custompath'] - If "id" is in meta map and "custompath" isn't then "${meta['id']}/custompath/" - is appended as a directory to "publish_dir" path - If publish_by_meta = false / null - No directories are appended to "publish_dir" path - publish_files = Groovy map where key = "file_ext" and value = "directory" to publish results for that file extension - The value of "directory" is appended to the standard "publish_dir" path as defined above. - If publish_files = null (unspecified) - All files are published. - If publish_files = false - No files are published. - suffix = File name suffix for output files. + ext.args = Additional arguments appended to command in module. + ext.args2 = Second set of arguments appended to command in module (multi-tool modules). + ext.args3 = Third set of arguments appended to command in module (multi-tool modules). + ext.prefix = File name prefix for output files. ---------------------------------------------------------------------------------------- */ -params { - modules { - 'fastqc' { - args = "--quiet" - } - 'multiqc' { - args = "" - } +process { + + publishDir = [ + path: { "${params.outdir}/${task.process.tokenize(':')[-1].tokenize('_')[0].toLowerCase()}" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + + withName: SAMPLESHEET_CHECK { + publishDir = [ + path: { "${params.outdir}/pipeline_info" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + + withName: FASTQC { + ext.args = '--quiet' } + + withName: CUSTOM_DUMPSOFTWAREVERSIONS { + publishDir = [ + path: { "${params.outdir}/pipeline_info" }, + mode: 'copy', + pattern: '*_versions.yml' + ] + } + } diff --git a/conf/test.config b/conf/test.config index cc60ec23e..3a199a627 100644 --- a/conf/test.config +++ b/conf/test.config @@ -16,8 +16,8 @@ params { // Limit resources so that this can run on GitHub Actions max_cpus = 2 - max_memory = 6.GB - max_time = 6.h + max_memory = '6.GB' + max_time = '6.h' // Input data // TODO nf-core: Specify the paths to your test data on nf-core/test-datasets diff --git a/docs/images/nf-core-chipseq_logo.png b/docs/images/nf-core-chipseq_logo.png deleted file mode 100644 index 076a6569fa97494d5031781a66907fdb159c4b25..0000000000000000000000000000000000000000 GIT binary patch literal 0 HcmV?d00001 literal 34565 zcmYhi1yodBxIa9A(lJPPiL@XcLze>5Eezcq!qBOdfRfTB-QCjNT}ls)bk}!y@4f%^ zorTM_#EG-dexB!7J4{(o77Lve9RvbleRwaW3IZW&gFpx`P?3RuIq#Gk0scaBe6QmI 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Service Unavailable

+

The server is temporarily unable to service your +request due to maintenance downtime or capacity +problems. Please try again later.

+

Additionally, a 503 Service Unavailable +error was encountered while trying to use an ErrorDocument to handle the request.

+ diff --git a/docs/output.md b/docs/output.md index 27ece4791..b9c8a3df6 100644 --- a/docs/output.md +++ b/docs/output.md @@ -60,7 +60,7 @@ Results generated by MultiQC collate pipeline QC from supported tools e.g. FastQ * `pipeline_info/` * Reports generated by Nextflow: `execution_report.html`, `execution_timeline.html`, `execution_trace.txt` and `pipeline_dag.dot`/`pipeline_dag.svg`. - * Reports generated by the pipeline: `pipeline_report.html`, `pipeline_report.txt` and `software_versions.tsv`. + * Reports generated by the pipeline: `pipeline_report.html`, `pipeline_report.txt` and `software_versions.yml`. The `pipeline_report*` files will only be present if the `--email` / `--email_on_fail` parameter's are used when running the pipeline. * Reformatted samplesheet files used as input to the pipeline: `samplesheet.valid.csv`. diff --git a/docs/usage.md b/docs/usage.md index 49bda59c7..d1e7eebc7 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -181,42 +181,6 @@ process { > **NB:** We specify just the process name i.e. `STAR_ALIGN` in the config file and not the full task name string that is printed to screen in the error message or on the terminal whilst the pipeline is running i.e. `RNASEQ:ALIGN_STAR:STAR_ALIGN`. You may get a warning suggesting that the process selector isn't recognised but you can ignore that if the process name has been specified correctly. This is something that needs to be fixed upstream in core Nextflow. -### Tool-specific options - -For the ultimate flexibility, we have implemented and are using Nextflow DSL2 modules in a way where it is possible for both developers and users to change tool-specific command-line arguments (e.g. providing an additional command-line argument to the `STAR_ALIGN` process) as well as publishing options (e.g. saving files produced by the `STAR_ALIGN` process that aren't saved by default by the pipeline). In the majority of instances, as a user you won't have to change the default options set by the pipeline developer(s), however, there may be edge cases where creating a simple custom config file can improve the behaviour of the pipeline if for example it is failing due to a weird error that requires setting a tool-specific parameter to deal with smaller / larger genomes. - -The command-line arguments passed to STAR in the `STAR_ALIGN` module are a combination of: - -* Mandatory arguments or those that need to be evaluated within the scope of the module, as supplied in the [`script`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/modules/nf-core/software/star/align/main.nf#L49-L55) section of the module file. - -* An [`options.args`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/modules/nf-core/software/star/align/main.nf#L56) string of non-mandatory parameters that is set to be empty by default in the module but can be overwritten when including the module in the sub-workflow / workflow context via the `addParams` Nextflow option. - -The nf-core/rnaseq pipeline has a sub-workflow (see [terminology](https://github.com/nf-core/modules#terminology)) specifically to align reads with STAR and to sort, index and generate some basic stats on the resulting BAM files using SAMtools. At the top of this file we import the `STAR_ALIGN` module via the Nextflow [`include`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/subworkflows/nf-core/align_star.nf#L10) keyword and by default the options passed to the module via the `addParams` option are set as an empty Groovy map [here](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/subworkflows/nf-core/align_star.nf#L5); this in turn means `options.args` will be set to empty by default in the module file too. This is an intentional design choice and allows us to implement well-written sub-workflows composed of a chain of tools that by default run with the bare minimum parameter set for any given tool in order to make it much easier to share across pipelines and to provide the flexibility for users and developers to customise any non-mandatory arguments. - -When including the sub-workflow above in the main pipeline workflow we use the same `include` statement, however, we now have the ability to overwrite options for each of the tools in the sub-workflow including the [`align_options`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/workflows/rnaseq.nf#L225) variable that will be used specifically to overwrite the optional arguments passed to the `STAR_ALIGN` module. In this case, the options to be provided to `STAR_ALIGN` have been assigned sensible defaults by the developer(s) in the pipeline's [`modules.config`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/modules.config#L70-L74) and can be accessed and customised in the [workflow context](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/workflows/rnaseq.nf#L201-L204) too before eventually passing them to the sub-workflow as a Groovy map called `star_align_options`. These options will then be propagated from `workflow -> sub-workflow -> module`. - -As mentioned at the beginning of this section it may also be necessary for users to overwrite the options passed to modules to be able to customise specific aspects of the way in which a particular tool is executed by the pipeline. Given that all of the default module options are stored in the pipeline's `modules.config` as a [`params` variable](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/modules.config#L24-L25) it is also possible to overwrite any of these options via a custom config file. - -Say for example we want to append an additional, non-mandatory parameter (i.e. `--outFilterMismatchNmax 16`) to the arguments passed to the `STAR_ALIGN` module. Firstly, we need to copy across the default `args` specified in the [`modules.config`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/modules.config#L71) and create a custom config file that is a composite of the default `args` as well as the additional options you would like to provide. This is very important because Nextflow will overwrite the default value of `args` that you provide via the custom config. - -As you will see in the example below, we have: - -* appended `--outFilterMismatchNmax 16` to the default `args` used by the module. -* changed the default `publish_dir` value to where the files will eventually be published in the main results directory. -* appended `'bam':''` to the default value of `publish_files` so that the BAM files generated by the process will also be saved in the top-level results directory for the module. Note: `'out':'log'` means any file/directory ending in `out` will now be saved in a separate directory called `my_star_directory/log/`. - -```nextflow -params { - modules { - 'star_align' { - args = "--quantMode TranscriptomeSAM --twopassMode Basic --outSAMtype BAM Unsorted --readFilesCommand zcat --runRNGseed 0 --outFilterMultimapNmax 20 --alignSJDBoverhangMin 1 --outSAMattributes NH HI AS NM MD --quantTranscriptomeBan Singleend --outFilterMismatchNmax 16" - publish_dir = "my_star_directory" - publish_files = ['out':'log', 'tab':'log', 'bam':''] - } - } -} -``` - ### Updating containers The [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) implementation of this pipeline uses one container per process which makes it much easier to maintain and update software dependencies. If for some reason you need to use a different version of a particular tool with the pipeline then you just need to identify the `process` name and override the Nextflow `container` definition for that process using the `withName` declaration. For example, in the [nf-core/viralrecon](https://nf-co.re/viralrecon) pipeline a tool called [Pangolin](https://github.com/cov-lineages/pangolin) has been used during the COVID-19 pandemic to assign lineages to SARS-CoV-2 genome sequenced samples. Given that the lineage assignments change quite frequently it doesn't make sense to re-release the nf-core/viralrecon everytime a new version of Pangolin has been released. However, you can override the default container used by the pipeline by creating a custom config file and passing it as a command-line argument via `-c custom.config`. diff --git a/lib/NfcoreSchema.groovy b/lib/NfcoreSchema.groovy index 8d6920dd6..40ab65f20 100755 --- a/lib/NfcoreSchema.groovy +++ b/lib/NfcoreSchema.groovy @@ -105,9 +105,13 @@ class NfcoreSchema { // Collect expected parameters from the schema def expectedParams = [] + def enums = [:] for (group in schemaParams) { for (p in group.value['properties']) { expectedParams.push(p.key) + if (group.value['properties'][p.key].containsKey('enum')) { + enums[p.key] = group.value['properties'][p.key]['enum'] + } } } @@ -155,7 +159,7 @@ class NfcoreSchema { println '' log.error 'ERROR: Validation of pipeline parameters failed!' JSONObject exceptionJSON = e.toJSON() - printExceptions(exceptionJSON, params_json, log) + printExceptions(exceptionJSON, params_json, log, enums) println '' has_error = true } @@ -202,7 +206,7 @@ class NfcoreSchema { } def type = '[' + group_params.get(param).type + ']' def description = group_params.get(param).description - def defaultValue = group_params.get(param).default ? " [default: " + group_params.get(param).default.toString() + "]" : '' + def defaultValue = group_params.get(param).default != null ? " [default: " + group_params.get(param).default.toString() + "]" : '' def description_default = description + colors.dim + defaultValue + colors.reset // Wrap long description texts // Loosely based on https://dzone.com/articles/groovy-plain-text-word-wrap @@ -260,13 +264,12 @@ class NfcoreSchema { // Get pipeline parameters defined in JSON Schema def Map params_summary = [:] - def blacklist = ['hostnames'] def params_map = paramsLoad(getSchemaPath(workflow, schema_filename=schema_filename)) for (group in params_map.keySet()) { def sub_params = new LinkedHashMap() def group_params = params_map.get(group) // This gets the parameters of that particular group for (param in group_params.keySet()) { - if (params.containsKey(param) && !blacklist.contains(param)) { + if (params.containsKey(param)) { def params_value = params.get(param) def schema_value = group_params.get(param).default def param_type = group_params.get(param).type @@ -330,7 +333,7 @@ class NfcoreSchema { // // Loop over nested exceptions and print the causingException // - private static void printExceptions(ex_json, params_json, log) { + private static void printExceptions(ex_json, params_json, log, enums, limit=5) { def causingExceptions = ex_json['causingExceptions'] if (causingExceptions.length() == 0) { def m = ex_json['message'] =~ /required key \[([^\]]+)\] not found/ @@ -346,11 +349,20 @@ class NfcoreSchema { else { def param = ex_json['pointerToViolation'] - ~/^#\// def param_val = params_json[param].toString() - log.error "* --${param}: ${ex_json['message']} (${param_val})" + if (enums.containsKey(param)) { + def error_msg = "* --${param}: '${param_val}' is not a valid choice (Available choices" + if (enums[param].size() > limit) { + log.error "${error_msg} (${limit} of ${enums[param].size()}): ${enums[param][0..limit-1].join(', ')}, ... )" + } else { + log.error "${error_msg}: ${enums[param].join(', ')})" + } + } else { + log.error "* --${param}: ${ex_json['message']} (${param_val})" + } } } for (ex in causingExceptions) { - printExceptions(ex, params_json, log) + printExceptions(ex, params_json, log, enums) } } diff --git a/lib/NfcoreTemplate.groovy b/lib/NfcoreTemplate.groovy index 44551e0a3..2fc0a9b9b 100755 --- a/lib/NfcoreTemplate.groovy +++ b/lib/NfcoreTemplate.groovy @@ -19,27 +19,16 @@ class NfcoreTemplate { } // - // Check params.hostnames + // Warn if a -profile or Nextflow config has not been provided to run the pipeline // - public static void hostName(workflow, params, log) { - Map colors = logColours(params.monochrome_logs) - if (params.hostnames) { - try { - def hostname = "hostname".execute().text.trim() - params.hostnames.each { prof, hnames -> - hnames.each { hname -> - if (hostname.contains(hname) && !workflow.profile.contains(prof)) { - log.info "=${colors.yellow}====================================================${colors.reset}=\n" + - "${colors.yellow}WARN: You are running with `-profile $workflow.profile`\n" + - " but your machine hostname is ${colors.white}'$hostname'${colors.reset}.\n" + - " ${colors.yellow_bold}Please use `-profile $prof${colors.reset}`\n" + - "=${colors.yellow}====================================================${colors.reset}=" - } - } - } - } catch (Exception e) { - log.warn "[$workflow.manifest.name] Could not determine 'hostname' - skipping check. Reason: ${e.message}." - } + public static void checkConfigProvided(workflow, log) { + if (workflow.profile == 'standard' && workflow.configFiles.size() <= 1) { + log.warn "[$workflow.manifest.name] You are attempting to run the pipeline without any custom configuration!\n\n" + + "This will be dependent on your local compute environment but can be achieved via one or more of the following:\n" + + " (1) Using an existing pipeline profile e.g. `-profile docker` or `-profile singularity`\n" + + " (2) Using an existing nf-core/configs for your Institution e.g. `-profile crick` or `-profile uppmax`\n" + + " (3) Using your own local custom config e.g. `-c /path/to/your/custom.config`\n\n" + + "Please refer to the quick start section and usage docs for the pipeline.\n " } } @@ -168,7 +157,6 @@ class NfcoreTemplate { log.info "-${colors.purple}[$workflow.manifest.name]${colors.red} Pipeline completed successfully, but with errored process(es) ${colors.reset}-" } } else { - hostName(workflow, params, log) log.info "-${colors.purple}[$workflow.manifest.name]${colors.red} Pipeline completed with errors${colors.reset}-" } } diff --git a/lib/Utils.groovy b/lib/Utils.groovy index 18173e985..1b88aec0e 100755 --- a/lib/Utils.groovy +++ b/lib/Utils.groovy @@ -37,11 +37,4 @@ class Utils { "===================================================================================" } } - - // - // Join module args with appropriate spacing - // - public static String joinModuleArgs(args_list) { - return ' ' + args_list.join(' ') - } } diff --git a/lib/WorkflowMain.groovy b/lib/WorkflowMain.groovy index bc960fcc8..0bf58e435 100755 --- a/lib/WorkflowMain.groovy +++ b/lib/WorkflowMain.groovy @@ -61,6 +61,9 @@ class WorkflowMain { // Print parameter summary log to screen log.info paramsSummaryLog(workflow, params, log) + // Check that a -profile or Nextflow config has been provided to run the pipeline + NfcoreTemplate.checkConfigProvided(workflow, log) + // Check that conda channels are set-up correctly if (params.enable_conda) { Utils.checkCondaChannels(log) @@ -69,9 +72,6 @@ class WorkflowMain { // Check AWS batch settings NfcoreTemplate.awsBatch(workflow, params) - // Check the hostnames against configured profiles - NfcoreTemplate.hostName(workflow, params, log) - // Check input has been provided if (!params.input) { log.error "Please provide an input samplesheet to the pipeline e.g. '--input samplesheet.csv'" diff --git a/modules.json b/modules.json index a11f8855c..072fc172e 100644 --- a/modules.json +++ b/modules.json @@ -3,12 +3,15 @@ "homePage": "https://github.com/nf-core/chipseq", "repos": { "nf-core/modules": { + "custom/dumpsoftwareversions": { + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + }, "fastqc": { - "git_sha": "e937c7950af70930d1f34bb961403d9d2aa81c7d" + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "multiqc": { - "git_sha": "e937c7950af70930d1f34bb961403d9d2aa81c7d" + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" } } } -} +} \ No newline at end of file diff --git a/modules/local/functions.nf b/modules/local/functions.nf deleted file mode 100644 index da9da093d..000000000 --- a/modules/local/functions.nf +++ /dev/null @@ -1,68 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} diff --git a/modules/local/get_software_versions.nf b/modules/local/get_software_versions.nf deleted file mode 100644 index 3e9926b85..000000000 --- a/modules/local/get_software_versions.nf +++ /dev/null @@ -1,33 +0,0 @@ -// Import generic module functions -include { saveFiles } from './functions' - -params.options = [:] - -process GET_SOFTWARE_VERSIONS { - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'pipeline_info', meta:[:], publish_by_meta:[]) } - - conda (params.enable_conda ? "conda-forge::python=3.8.3" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/python:3.8.3" - } else { - container "quay.io/biocontainers/python:3.8.3" - } - - cache false - - input: - path versions - - output: - path "software_versions.tsv" , emit: tsv - path 'software_versions_mqc.yaml', emit: yaml - - script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - """ - echo $workflow.manifest.version > pipeline.version.txt - echo $workflow.nextflow.version > nextflow.version.txt - scrape_software_versions.py &> software_versions_mqc.yaml - """ -} diff --git a/modules/local/samplesheet_check.nf b/modules/local/samplesheet_check.nf index b200e6ffb..5094e5a0f 100644 --- a/modules/local/samplesheet_check.nf +++ b/modules/local/samplesheet_check.nf @@ -1,31 +1,27 @@ -// Import generic module functions -include { saveFiles } from './functions' - -params.options = [:] - process SAMPLESHEET_CHECK { tag "$samplesheet" - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:'pipeline_info', meta:[:], publish_by_meta:[]) } conda (params.enable_conda ? "conda-forge::python=3.8.3" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/python:3.8.3" - } else { - container "quay.io/biocontainers/python:3.8.3" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/python:3.8.3' : + 'quay.io/biocontainers/python:3.8.3' }" input: path samplesheet output: - path '*.csv' + path '*.csv' , emit: csv + path "versions.yml", emit: versions script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ """ check_samplesheet.py \\ $samplesheet \\ samplesheet.valid.csv + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + python: \$(python --version | sed 's/Python //g') + END_VERSIONS """ } diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf b/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf new file mode 100644 index 000000000..934bb4672 --- /dev/null +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf @@ -0,0 +1,21 @@ +process CUSTOM_DUMPSOFTWAREVERSIONS { + label 'process_low' + + // Requires `pyyaml` which does not have a dedicated container but is in the MultiQC container + conda (params.enable_conda ? "bioconda::multiqc=1.11" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/multiqc:1.11--pyhdfd78af_0' : + 'quay.io/biocontainers/multiqc:1.11--pyhdfd78af_0' }" + + input: + path versions + + output: + path "software_versions.yml" , emit: yml + path "software_versions_mqc.yml", emit: mqc_yml + path "versions.yml" , emit: versions + + script: + def args = task.ext.args ?: '' + template 'dumpsoftwareversions.py' +} diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml b/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml new file mode 100644 index 000000000..5b5b8a602 --- /dev/null +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml @@ -0,0 +1,34 @@ +name: custom_dumpsoftwareversions +description: Custom module used to dump software versions within the nf-core pipeline template +keywords: + - custom + - version +tools: + - custom: + description: Custom module used to dump software versions within the nf-core pipeline template + homepage: https://github.com/nf-core/tools + documentation: https://github.com/nf-core/tools + licence: ['MIT'] +input: + - versions: + type: file + description: YML file containing software versions + pattern: "*.yml" + +output: + - yml: + type: file + description: Standard YML file containing software versions + pattern: "software_versions.yml" + - mqc_yml: + type: file + description: MultiQC custom content YML file containing software versions + pattern: "software_versions_mqc.yml" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" + +authors: + - "@drpatelh" + - "@grst" diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/templates/dumpsoftwareversions.py b/modules/nf-core/modules/custom/dumpsoftwareversions/templates/dumpsoftwareversions.py new file mode 100644 index 000000000..d13903925 --- /dev/null +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/templates/dumpsoftwareversions.py @@ -0,0 +1,89 @@ +#!/usr/bin/env python + +import yaml +import platform +from textwrap import dedent + + +def _make_versions_html(versions): + html = [ + dedent( + """\\ + + + + + + + + + + """ + ) + ] + for process, tmp_versions in sorted(versions.items()): + html.append("") + for i, (tool, version) in enumerate(sorted(tmp_versions.items())): + html.append( + dedent( + f"""\\ + + + + + + """ + ) + ) + html.append("") + html.append("
Process Name Software Version
{process if (i == 0) else ''}{tool}{version}
") + return "\\n".join(html) + + +versions_this_module = {} +versions_this_module["${task.process}"] = { + "python": platform.python_version(), + "yaml": yaml.__version__, +} + +with open("$versions") as f: + versions_by_process = yaml.load(f, Loader=yaml.BaseLoader) | versions_this_module + +# aggregate versions by the module name (derived from fully-qualified process name) +versions_by_module = {} +for process, process_versions in versions_by_process.items(): + module = process.split(":")[-1] + try: + assert versions_by_module[module] == process_versions, ( + "We assume that software versions are the same between all modules. " + "If you see this error-message it means you discovered an edge-case " + "and should open an issue in nf-core/tools. " + ) + except KeyError: + versions_by_module[module] = process_versions + +versions_by_module["Workflow"] = { + "Nextflow": "$workflow.nextflow.version", + "$workflow.manifest.name": "$workflow.manifest.version", +} + +versions_mqc = { + "id": "software_versions", + "section_name": "${workflow.manifest.name} Software Versions", + "section_href": "https://github.com/${workflow.manifest.name}", + "plot_type": "html", + "description": "are collected at run time from the software output.", + "data": _make_versions_html(versions_by_module), +} + +with open("software_versions.yml", "w") as f: + yaml.dump(versions_by_module, f, default_flow_style=False) +with open("software_versions_mqc.yml", "w") as f: + yaml.dump(versions_mqc, f, default_flow_style=False) + +with open("versions.yml", "w") as f: + yaml.dump(versions_this_module, f, default_flow_style=False) diff --git a/modules/nf-core/modules/fastqc/functions.nf b/modules/nf-core/modules/fastqc/functions.nf deleted file mode 100644 index da9da093d..000000000 --- a/modules/nf-core/modules/fastqc/functions.nf +++ /dev/null @@ -1,68 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} diff --git a/modules/nf-core/modules/fastqc/main.nf b/modules/nf-core/modules/fastqc/main.nf index 39c327b26..d250eca07 100644 --- a/modules/nf-core/modules/fastqc/main.nf +++ b/modules/nf-core/modules/fastqc/main.nf @@ -1,22 +1,11 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process FASTQC { tag "$meta.id" label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:meta, publish_by_meta:['id']) } conda (params.enable_conda ? "bioconda::fastqc=0.11.9" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0" - } else { - container "quay.io/biocontainers/fastqc:0.11.9--0" - } + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/fastqc:0.11.9--0' : + 'quay.io/biocontainers/fastqc:0.11.9--0' }" input: tuple val(meta), path(reads) @@ -24,24 +13,32 @@ process FASTQC { output: tuple val(meta), path("*.html"), emit: html tuple val(meta), path("*.zip") , emit: zip - path "*.version.txt" , emit: version + path "versions.yml" , emit: versions script: + def args = task.ext.args ?: '' // Add soft-links to original FastQs for consistent naming in pipeline - def software = getSoftwareName(task.process) - def prefix = options.suffix ? "${meta.id}${options.suffix}" : "${meta.id}" + def prefix = task.ext.prefix ?: "${meta.id}" if (meta.single_end) { """ [ ! -f ${prefix}.fastq.gz ] && ln -s $reads ${prefix}.fastq.gz - fastqc $options.args --threads $task.cpus ${prefix}.fastq.gz - fastqc --version | sed -e "s/FastQC v//g" > ${software}.version.txt + fastqc $args --threads $task.cpus ${prefix}.fastq.gz + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + fastqc: \$( fastqc --version | sed -e "s/FastQC v//g" ) + END_VERSIONS """ } else { """ [ ! -f ${prefix}_1.fastq.gz ] && ln -s ${reads[0]} ${prefix}_1.fastq.gz [ ! -f ${prefix}_2.fastq.gz ] && ln -s ${reads[1]} ${prefix}_2.fastq.gz - fastqc $options.args --threads $task.cpus ${prefix}_1.fastq.gz ${prefix}_2.fastq.gz - fastqc --version | sed -e "s/FastQC v//g" > ${software}.version.txt + fastqc $args --threads $task.cpus ${prefix}_1.fastq.gz ${prefix}_2.fastq.gz + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + fastqc: \$( fastqc --version | sed -e "s/FastQC v//g" ) + END_VERSIONS """ } } diff --git a/modules/nf-core/modules/fastqc/meta.yml b/modules/nf-core/modules/fastqc/meta.yml index 8eb9953dc..b09553a3c 100644 --- a/modules/nf-core/modules/fastqc/meta.yml +++ b/modules/nf-core/modules/fastqc/meta.yml @@ -15,6 +15,7 @@ tools: overrepresented sequences. homepage: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/ documentation: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/ + licence: ['GPL-2.0-only'] input: - meta: type: map @@ -40,10 +41,10 @@ output: type: file description: FastQC report archive pattern: "*_{fastqc.zip}" - - version: + - versions: type: file - description: File containing software version - pattern: "*.{version.txt}" + description: File containing software versions + pattern: "versions.yml" authors: - "@drpatelh" - "@grst" diff --git a/modules/nf-core/modules/multiqc/functions.nf b/modules/nf-core/modules/multiqc/functions.nf deleted file mode 100644 index da9da093d..000000000 --- a/modules/nf-core/modules/multiqc/functions.nf +++ /dev/null @@ -1,68 +0,0 @@ -// -// Utility functions used in nf-core DSL2 module files -// - -// -// Extract name of software tool from process name using $task.process -// -def getSoftwareName(task_process) { - return task_process.tokenize(':')[-1].tokenize('_')[0].toLowerCase() -} - -// -// Function to initialise default values and to generate a Groovy Map of available options for nf-core modules -// -def initOptions(Map args) { - def Map options = [:] - options.args = args.args ?: '' - options.args2 = args.args2 ?: '' - options.args3 = args.args3 ?: '' - options.publish_by_meta = args.publish_by_meta ?: [] - options.publish_dir = args.publish_dir ?: '' - options.publish_files = args.publish_files - options.suffix = args.suffix ?: '' - return options -} - -// -// Tidy up and join elements of a list to return a path string -// -def getPathFromList(path_list) { - def paths = path_list.findAll { item -> !item?.trim().isEmpty() } // Remove empty entries - paths = paths.collect { it.trim().replaceAll("^[/]+|[/]+\$", "") } // Trim whitespace and trailing slashes - return paths.join('/') -} - -// -// Function to save/publish module results -// -def saveFiles(Map args) { - if (!args.filename.endsWith('.version.txt')) { - def ioptions = initOptions(args.options) - def path_list = [ ioptions.publish_dir ?: args.publish_dir ] - if (ioptions.publish_by_meta) { - def key_list = ioptions.publish_by_meta instanceof List ? ioptions.publish_by_meta : args.publish_by_meta - for (key in key_list) { - if (args.meta && key instanceof String) { - def path = key - if (args.meta.containsKey(key)) { - path = args.meta[key] instanceof Boolean ? "${key}_${args.meta[key]}".toString() : args.meta[key] - } - path = path instanceof String ? path : '' - path_list.add(path) - } - } - } - if (ioptions.publish_files instanceof Map) { - for (ext in ioptions.publish_files) { - if (args.filename.endsWith(ext.key)) { - def ext_list = path_list.collect() - ext_list.add(ext.value) - return "${getPathFromList(ext_list)}/$args.filename" - } - } - } else if (ioptions.publish_files == null) { - return "${getPathFromList(path_list)}/$args.filename" - } - } -} diff --git a/modules/nf-core/modules/multiqc/main.nf b/modules/nf-core/modules/multiqc/main.nf index da7808002..3dceb162a 100644 --- a/modules/nf-core/modules/multiqc/main.nf +++ b/modules/nf-core/modules/multiqc/main.nf @@ -1,21 +1,10 @@ -// Import generic module functions -include { initOptions; saveFiles; getSoftwareName } from './functions' - -params.options = [:] -options = initOptions(params.options) - process MULTIQC { label 'process_medium' - publishDir "${params.outdir}", - mode: params.publish_dir_mode, - saveAs: { filename -> saveFiles(filename:filename, options:params.options, publish_dir:getSoftwareName(task.process), meta:[:], publish_by_meta:[]) } - conda (params.enable_conda ? "bioconda::multiqc=1.10.1" : null) - if (workflow.containerEngine == 'singularity' && !params.singularity_pull_docker_container) { - container "https://depot.galaxyproject.org/singularity/multiqc:1.10.1--py_0" - } else { - container "quay.io/biocontainers/multiqc:1.10.1--py_0" - } + conda (params.enable_conda ? 'bioconda::multiqc=1.11' : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/multiqc:1.11--pyhdfd78af_0' : + 'quay.io/biocontainers/multiqc:1.11--pyhdfd78af_0' }" input: path multiqc_files @@ -24,12 +13,16 @@ process MULTIQC { path "*multiqc_report.html", emit: report path "*_data" , emit: data path "*_plots" , optional:true, emit: plots - path "*.version.txt" , emit: version + path "versions.yml" , emit: versions script: - def software = getSoftwareName(task.process) + def args = task.ext.args ?: '' """ - multiqc -f $options.args . - multiqc --version | sed -e "s/multiqc, version //g" > ${software}.version.txt + multiqc -f $args . + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + multiqc: \$( multiqc --version | sed -e "s/multiqc, version //g" ) + END_VERSIONS """ } diff --git a/modules/nf-core/modules/multiqc/meta.yml b/modules/nf-core/modules/multiqc/meta.yml index 532a8bb1e..63c75a450 100644 --- a/modules/nf-core/modules/multiqc/meta.yml +++ b/modules/nf-core/modules/multiqc/meta.yml @@ -11,6 +11,7 @@ tools: It's a general use tool, perfect for summarising the output from numerous bioinformatics tools. homepage: https://multiqc.info/ documentation: https://multiqc.info/docs/ + licence: ['GPL-3.0-or-later'] input: - multiqc_files: type: file @@ -29,10 +30,10 @@ output: type: file description: Plots created by MultiQC pattern: "*_data" - - version: + - versions: type: file - description: File containing software version - pattern: "*.{version.txt}" + description: File containing software versions + pattern: "versions.yml" authors: - "@abhi18av" - "@bunop" diff --git a/nextflow.config b/nextflow.config index 4f7ea7561..e5ae4e45b 100644 --- a/nextflow.config +++ b/nextflow.config @@ -26,7 +26,6 @@ params { // Boilerplate options outdir = './results' tracedir = "${params.outdir}/pipeline_info" - publish_dir_mode = 'copy' email = null email_on_fail = null plaintext_email = false @@ -34,14 +33,12 @@ params { help = false validate_params = true show_hidden_params = false - schema_ignore_params = 'genomes,modules' + schema_ignore_params = 'genomes' enable_conda = false - singularity_pull_docker_container = false // Config options custom_config_version = 'master' custom_config_base = "https://raw.githubusercontent.com/nf-core/configs/${params.custom_config_version}" - hostnames = [:] config_profile_description = null config_profile_contact = null config_profile_url = null @@ -58,9 +55,6 @@ params { // Load base.config by default for all pipelines includeConfig 'conf/base.config' -// Load modules.config for DSL2 module specific options -includeConfig 'conf/modules.config' - // Load nf-core custom profiles from different Institutions try { includeConfig "${params.custom_config_base}/nfcore_custom.config" @@ -68,13 +62,6 @@ try { System.err.println("WARNING: Could not load nf-core/config profiles: ${params.custom_config_base}/nfcore_custom.config") } -// Load igenomes.config if required -if (!params.igenomes_ignore) { - includeConfig 'conf/igenomes.config' -} else { - params.genomes = [:] -} - profiles { debug { process.beforeScript = 'echo $HOSTNAME' } conda { @@ -126,11 +113,22 @@ profiles { test_full { includeConfig 'conf/test_full.config' } } +// Load igenomes.config if required +if (!params.igenomes_ignore) { + includeConfig 'conf/igenomes.config' +} else { + params.genomes = [:] +} + // Export these variables to prevent local Python/R libraries from conflicting with those in the container +// The JULIA depot path has been adjusted to a fixed path `/usr/local/share/julia` that needs to be used for packages in the container. +// See https://apeltzer.github.io/post/03-julia-lang-nextflow/ for details on that. Once we have a common agreement on where to keep Julia packages, this is adjustable. + env { PYTHONNOUSERSITE = 1 R_PROFILE_USER = "/.Rprofile" R_ENVIRON_USER = "/.Renviron" + JULIA_DEPOT_PATH = "/usr/local/share/julia" } // Capture exit codes from upstream processes when piping @@ -160,10 +158,13 @@ manifest { homePage = 'https://github.com/nf-core/chipseq' description = 'ChIP-seq peak-calling and differential analysis pipeline.' mainScript = 'main.nf' - nextflowVersion = '!>=21.04.0' + nextflowVersion = '!>=21.10.3' version = '1.3.0dev' } +// Load modules.config for DSL2 module specific options +includeConfig 'conf/modules.config' + // Function to ensure that resource requirements don't go beyond // a maximum limit def check_max(obj, type) { diff --git a/nextflow_schema.json b/nextflow_schema.json index 2c3b9f6e3..91a37921a 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -104,12 +104,6 @@ "help_text": "If you're running offline, Nextflow will not be able to fetch the institutional config files from the internet. If you don't need them, then this is not a problem. If you do need them, you should download the files from the repo and tell Nextflow where to find them with this parameter.", "fa_icon": "fas fa-users-cog" }, - "hostnames": { - "type": "string", - "description": "Institutional configs hostname.", - "hidden": true, - "fa_icon": "fas fa-users-cog" - }, "config_profile_name": { "type": "string", "description": "Institutional config name.", @@ -184,22 +178,6 @@ "fa_icon": "fas fa-question-circle", "hidden": true }, - "publish_dir_mode": { - "type": "string", - "default": "copy", - "description": "Method used to save pipeline results to output directory.", - "help_text": "The Nextflow `publishDir` option specifies which intermediate files should be saved to the output directory. This option tells the pipeline what method should be used to move these files. See [Nextflow docs](https://www.nextflow.io/docs/latest/process.html#publishdir) for details.", - "fa_icon": "fas fa-copy", - "enum": [ - "symlink", - "rellink", - "link", - "copy", - "copyNoFollow", - "move" - ], - "hidden": true - }, "email_on_fail": { "type": "string", "description": "Email address for completion summary, only when pipeline fails.", @@ -260,13 +238,6 @@ "description": "Run this workflow with Conda. You can also use '-profile conda' instead of providing this parameter.", "hidden": true, "fa_icon": "fas fa-bacon" - }, - "singularity_pull_docker_container": { - "type": "boolean", - "description": "Instead of directly downloading Singularity images for use with Singularity, force the workflow to pull and convert Docker containers instead.", - "hidden": true, - "fa_icon": "fas fa-toolbox", - "help_text": "This may be useful for example if you are unable to directly pull Singularity containers to run the pipeline due to http/https proxy issues." } } } diff --git a/subworkflows/local/input_check.nf b/subworkflows/local/input_check.nf index b664bc8ca..cddcbb3ce 100644 --- a/subworkflows/local/input_check.nf +++ b/subworkflows/local/input_check.nf @@ -2,9 +2,7 @@ // Check input samplesheet and get read channels // -params.options = [:] - -include { SAMPLESHEET_CHECK } from '../../modules/local/samplesheet_check' addParams( options: params.options ) +include { SAMPLESHEET_CHECK } from '../../modules/local/samplesheet_check' workflow INPUT_CHECK { take: @@ -12,12 +10,14 @@ workflow INPUT_CHECK { main: SAMPLESHEET_CHECK ( samplesheet ) + .csv .splitCsv ( header:true, sep:',' ) .map { create_fastq_channels(it) } .set { reads } emit: - reads // channel: [ val(meta), [ reads ] ] + reads // channel: [ val(meta), [ reads ] ] + versions = SAMPLESHEET_CHECK.out.versions // channel: [ versions.yml ] } // Function to get list of [ meta, [ fastq_1, fastq_2 ] ] diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 46b8fb78f..5714aa820 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -32,18 +32,10 @@ ch_multiqc_custom_config = params.multiqc_config ? Channel.fromPath(params.multi ======================================================================================== */ -// Don't overwrite global params.modules, create a copy instead and use that within the main script. -def modules = params.modules.clone() - -// -// MODULE: Local to the pipeline -// -include { GET_SOFTWARE_VERSIONS } from '../modules/local/get_software_versions' addParams( options: [publish_files : ['tsv':'']] ) - // // SUBWORKFLOW: Consisting of a mix of local and nf-core/modules // -include { INPUT_CHECK } from '../subworkflows/local/input_check' addParams( options: [:] ) +include { INPUT_CHECK } from '../subworkflows/local/input_check' /* ======================================================================================== @@ -51,14 +43,12 @@ include { INPUT_CHECK } from '../subworkflows/local/input_check' addParams( opti ======================================================================================== */ -def multiqc_options = modules['multiqc'] -multiqc_options.args += params.multiqc_title ? Utils.joinModuleArgs(["--title \"$params.multiqc_title\""]) : '' - // // MODULE: Installed directly from nf-core/modules // -include { FASTQC } from '../modules/nf-core/modules/fastqc/main' addParams( options: modules['fastqc'] ) -include { MULTIQC } from '../modules/nf-core/modules/multiqc/main' addParams( options: multiqc_options ) +include { FASTQC } from '../modules/nf-core/modules/fastqc/main' +include { MULTIQC } from '../modules/nf-core/modules/multiqc/main' +include { CUSTOM_DUMPSOFTWAREVERSIONS } from '../modules/nf-core/modules/custom/dumpsoftwareversions/main' /* ======================================================================================== @@ -71,7 +61,7 @@ def multiqc_report = [] workflow CHIPSEQ { - ch_software_versions = Channel.empty() + ch_versions = Channel.empty() // // SUBWORKFLOW: Read in samplesheet, validate and stage input files @@ -79,6 +69,7 @@ workflow CHIPSEQ { INPUT_CHECK ( ch_input ) + ch_versions = ch_versions.mix(INPUT_CHECK.out.versions) // // MODULE: Run FastQC @@ -86,21 +77,10 @@ workflow CHIPSEQ { FASTQC ( INPUT_CHECK.out.reads ) - ch_software_versions = ch_software_versions.mix(FASTQC.out.version.first().ifEmpty(null)) + ch_versions = ch_versions.mix(FASTQC.out.versions.first()) - // - // MODULE: Pipeline reporting - // - ch_software_versions - .map { it -> if (it) [ it.baseName, it ] } - .groupTuple() - .map { it[1][0] } - .flatten() - .collect() - .set { ch_software_versions } - - GET_SOFTWARE_VERSIONS ( - ch_software_versions.map { it }.collect() + CUSTOM_DUMPSOFTWAREVERSIONS ( + ch_versions.unique().collectFile(name: 'collated_versions.yml') ) // @@ -113,14 +93,14 @@ workflow CHIPSEQ { ch_multiqc_files = ch_multiqc_files.mix(Channel.from(ch_multiqc_config)) ch_multiqc_files = ch_multiqc_files.mix(ch_multiqc_custom_config.collect().ifEmpty([])) ch_multiqc_files = ch_multiqc_files.mix(ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml')) - ch_multiqc_files = ch_multiqc_files.mix(GET_SOFTWARE_VERSIONS.out.yaml.collect()) + ch_multiqc_files = ch_multiqc_files.mix(CUSTOM_DUMPSOFTWAREVERSIONS.out.mqc_yml.collect()) ch_multiqc_files = ch_multiqc_files.mix(FASTQC.out.zip.collect{it[1]}.ifEmpty([])) MULTIQC ( ch_multiqc_files.collect() ) - multiqc_report = MULTIQC.out.report.toList() - ch_software_versions = ch_software_versions.mix(MULTIQC.out.version.ifEmpty(null)) + multiqc_report = MULTIQC.out.report.toList() + ch_versions = ch_versions.mix(MULTIQC.out.versions) } /* From 5f5f534465c38bf6f908cc75b57ea6371fe72d99 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 16 Dec 2021 00:10:10 +0100 Subject: [PATCH 257/538] Update modules.config --- conf/modules.config | 63 ++++++++++++++++++++------------------------- 1 file changed, 28 insertions(+), 35 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index af9af4b4b..4d4d39fa0 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -96,8 +96,33 @@ process { enabled: params.save_reference ] } - - + withName: '.*:FASTQC_TRIMGALORE:FASTQC' { + ext.args = '--quiet' + } + withName: '.*:FASTQC_TRIMGALORE:TRIMGALORE' { + ext.args = [ + '--fastqc', + params.trim_nextseq > 0 ? "--nextseq ${params.trim_nextseq}" : '' + ].join(' ').trim() + publishDir = [ + [ + path: { "${params.outdir}/trimgalore/fastqc" }, + mode: 'copy', + pattern: "*.{html,zip}" + ], + [ + path: { "${params.outdir}/trimgalore" }, + mode: 'copy', + pattern: "*.fq.gz", + enabled: params.save_trimmed + ], + [ + path: { "${params.outdir}/trimgalore" }, + mode: 'copy', + pattern: "*.txt" + ] + ] + } withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_BWA_MEM:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { // TODO: substitute by this line when multiple aligners are implemented // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { @@ -157,30 +182,6 @@ process { // process { - // withName: TRIMGALORE { - // ext.args = [ - // '--fastqc', - // params.trim_nextseq > 0 ? "--nextseq ${params.trim_nextseq}" : '' - // ].join(' ').trim() - // publishDir = [ - // [ - // path: { "${params.outdir}/trimgalore/fastqc" }, - // mode: copy, - // pattern: "*.{html,zip}" - // ], - // [ - // path: { "${params.outdir}/trimgalore" }, - // mode: copy, - // pattern: "*.fq.gz", - // enabled: params.save_trimmed - // ], - // [ - // path: { "${params.outdir}/trimgalore" }, - // mode: copy, - // pattern: "*.txt" - // ] - // ] - // } withName: BWA_MEM { ext.args = [ '-M', @@ -393,7 +394,7 @@ process { withName: '.*:MARK_DUPLICATES_PICARD:BAM_STATS_SAMTOOLS:.*' { publishDir = [ - path: { "${params.outdir}/${params.aligner}/samtools_stats" }, + path: { "${params.outdir}/bwa/samtools_stats" }, mode: 'copy', pattern: '*.{stats,flagstat,idxstats}' ] @@ -401,14 +402,6 @@ process { // } } -if (!params.skip_fastqc) { - process { - withName: FASTQC { - ext.args = '--quiet' - } - } -} - // here if (params.macs_gsize) { process { From 448d99c653b5fa6a6f3e3db840283b34a672243e Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 20 Dec 2021 18:52:17 +0100 Subject: [PATCH 258/538] Fix usage.md --- docs/usage.md | 44 -------------------------------------------- 1 file changed, 44 deletions(-) diff --git a/docs/usage.md b/docs/usage.md index 37343e096..3a0490c45 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -84,50 +84,6 @@ The minimum reference genome requirements are a FASTA and GTF file, all other fi > **NB:** Compressed reference files are also supported by the pipeline i.e. standard files with the `.gz` extension and indices folders with the `tar.gz` extension. -## Samplesheet input - -You will need to create a samplesheet with information about the samples you would like to analyse before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 3 columns, and a header row as shown in the examples below. - -```console ---input '[path to samplesheet file]' -``` - -### Multiple runs of the same sample - -The `sample` identifiers have to be the same when you have re-sequenced the same sample more than once e.g. to increase sequencing depth. The pipeline will concatenate the raw reads before performing any downstream analysis. Below is an example for the same sample sequenced across 3 lanes: - -```console -sample,fastq_1,fastq_2 -CONTROL_REP1,AEG588A1_S1_L002_R1_001.fastq.gz,AEG588A1_S1_L002_R2_001.fastq.gz -CONTROL_REP1,AEG588A1_S1_L003_R1_001.fastq.gz,AEG588A1_S1_L003_R2_001.fastq.gz -CONTROL_REP1,AEG588A1_S1_L004_R1_001.fastq.gz,AEG588A1_S1_L004_R2_001.fastq.gz -``` - -### Full samplesheet - -The pipeline will auto-detect whether a sample is single- or paired-end using the information provided in the samplesheet. The samplesheet can have as many columns as you desire, however, there is a strict requirement for the first 3 columns to match those defined in the table below. - -A final samplesheet file consisting of both single- and paired-end data may look something like the one below. This is for 6 samples, where `TREATMENT_REP3` has been sequenced twice. - -```console -sample,fastq_1,fastq_2 -CONTROL_REP1,AEG588A1_S1_L002_R1_001.fastq.gz,AEG588A1_S1_L002_R2_001.fastq.gz -CONTROL_REP2,AEG588A2_S2_L002_R1_001.fastq.gz,AEG588A2_S2_L002_R2_001.fastq.gz -CONTROL_REP3,AEG588A3_S3_L002_R1_001.fastq.gz,AEG588A3_S3_L002_R2_001.fastq.gz -TREATMENT_REP1,AEG588A4_S4_L003_R1_001.fastq.gz, -TREATMENT_REP2,AEG588A5_S5_L003_R1_001.fastq.gz, -TREATMENT_REP3,AEG588A6_S6_L003_R1_001.fastq.gz, -TREATMENT_REP3,AEG588A6_S6_L004_R1_001.fastq.gz, -``` - -| Column | Description | -|----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------| -| `sample` | Custom sample name. This entry will be identical for multiple sequencing libraries/runs from the same sample. Spaces in sample names are automatically converted to underscores (`_`). | -| `fastq_1` | Full path to FastQ file for Illumina short reads 1. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | -| `fastq_2` | Full path to FastQ file for Illumina short reads 2. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | - -An [example samplesheet](../assets/samplesheet.csv) has been provided with the pipeline. - ## Running the pipeline The typical command for running the pipeline is as follows: From 627f0516269dd10fe5576ef29bf74b1cc2094018 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 20 Dec 2021 19:00:03 +0100 Subject: [PATCH 259/538] Update nextflow ver in ci.yml for testing params --- .github/workflows/ci.yml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 0773e2c6a..5bf66d594 100755 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -51,7 +51,7 @@ jobs: if: ${{ github.event_name != 'push' || (github.event_name == 'push' && github.repository == 'nf-core/chipseq') }} runs-on: ubuntu-latest env: - NXF_VER: '21.04.0' + NXF_VER: '21.10.3' NXF_ANSI_LOG: false strategy: matrix: From caa26f17bff99b6cce377aa4386ddc4ba57ed043 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 20 Dec 2021 22:13:08 +0100 Subject: [PATCH 260/538] Remove singularity_pull_docker_container from config --- nextflow.config | 1 - 1 file changed, 1 deletion(-) diff --git a/nextflow.config b/nextflow.config index 2f01be186..c13bae66c 100644 --- a/nextflow.config +++ b/nextflow.config @@ -82,7 +82,6 @@ params { show_hidden_params = false schema_ignore_params = 'genomes,modules' enable_conda = false - singularity_pull_docker_container = false // Config options custom_config_version = 'master' From 7b7e77bf43f83b000c00653483eaee437344da5c Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 20 Dec 2021 22:13:54 +0100 Subject: [PATCH 261/538] Add templalte light log --- docs/images/nf-core-chipseq_logo_light.png | Bin 428 -> 73788 bytes 1 file changed, 0 insertions(+), 0 deletions(-) diff --git a/docs/images/nf-core-chipseq_logo_light.png b/docs/images/nf-core-chipseq_logo_light.png index 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J-waT~81OO72jb}RoLJM9sUyE8jGGwP=P zT({r52Hx8DE$sF$+szslcT#Se_EpNdtuM&KawTQ+v8aUV!(c1b6Y4w!6D(Cvt4H`E zKADbS@9>1i;=z)V7g#7c)78Q2R21&3KiPRN)L6AW!IagA!AuZn7(F8!n;^O(3&GEL z`IdZS!SoYp3ZUbR4QN~-hc4sVpItBmfoJG&#Lk2yM)p}|n3k}!gi}7^1bED6U@;Ic zl^ka$&sv*cyhCf#Eg<}pQxJ33KjQ@CIv?|QCJpD_6tkR+I~LC|e?kXMA=kc(1G!N4 VJvv>8IrcTl)qtG)%H@^D#V=*Sk$eCE From b1bd7bc452edc03babde54c080c178d6346aa870 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 21 Dec 2021 12:21:49 +0100 Subject: [PATCH 262/538] Add IGV module again --- conf/modules.config | 347 +++++++++++-------------------------------- modules/local/igv.nf | 12 +- workflows/chipseq.nf | 27 ++-- 3 files changed, 106 insertions(+), 280 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 6269b8403..522482121 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -51,7 +51,7 @@ process { enabled: params.save_reference ] } - // withName: 'UNTAR.*' { + // withName: 'UNTAR_.*' { withName: 'UNTAR' { publishDir = [ path: { "${params.outdir}/genome/index" }, @@ -106,34 +106,45 @@ process { // // Read QC and trimming options // -process { - withName: '.*:FASTQC_TRIMGALORE:FASTQC' { - ext.args = '--quiet' + +if (!(params.skip_fastqc || params.skip_qc)) { + process { + withName: '.*:FASTQC_TRIMGALORE:FASTQC' { + ext.args = '--quiet' + } } - withName: '.*:FASTQC_TRIMGALORE:TRIMGALORE' { - ext.args = [ - '--fastqc', - params.trim_nextseq > 0 ? "--nextseq ${params.trim_nextseq}" : '' - ].join(' ').trim() - publishDir = [ - [ - path: { "${params.outdir}/trimgalore/fastqc" }, - mode: 'copy', - pattern: "*.{html,zip}" - ], - [ - path: { "${params.outdir}/trimgalore" }, - mode: 'copy', - pattern: "*.fq.gz", - enabled: params.save_trimmed - ], - [ - path: { "${params.outdir}/trimgalore" }, - mode: 'copy', - pattern: "*.txt" +} + +if (!params.skip_trimming) { + process { + withName: '.*:FASTQC_TRIMGALORE:TRIMGALORE' { + ext.args = [ + '--fastqc', + params.trim_nextseq > 0 ? "--nextseq ${params.trim_nextseq}" : '' + ].join(' ').trim() + publishDir = [ + [ + path: { "${params.outdir}/trimgalore/fastqc" }, + mode: 'copy', + pattern: "*.{html,zip}" + ], + [ + path: { "${params.outdir}/trimgalore" }, + mode: 'copy', + pattern: "*.fq.gz", + enabled: params.save_trimmed + ], + [ + path: { "${params.outdir}/trimgalore" }, + mode: 'copy', + pattern: "*.txt" + ] ] - ] + } } +} + +process { withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_BWA_MEM:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { // TODO: substitute by this line when multiple aligners are implemented // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { @@ -169,30 +180,6 @@ process { enabled: params.save_align_intermeds ] } - // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { - // ext.args = params.bam_csi_index ? '-c' : '' - // publishDir = [ - // path: { "${params.outdir}/${params.aligner}" }, - // mode: 'copy', - // pattern: "*.{bam,csi}", - // enabled: ( ['star_salmon','hisat2'].contains(params.aligner) && - // ( params.save_align_intermeds || - // ( !params.with_umi && params.skip_markduplicates ) - // ) - // ) || params.save_align_intermeds || params.skip_markduplicates - // ] - // } - // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:.*' { - // publishDir = [ - // path: { "${params.outdir}/${params.aligner}/samtools_stats" }, - // mode: 'copy', - // pattern: "*.{stats,flagstat,idxstats}" - // ] - // } -// } - -// process { - withName: BWA_MEM { ext.args = [ '-M', @@ -206,14 +193,6 @@ process { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - // withName: SAMTOOLS_SORT_LIB { - // ext.prefix = { "${meta.id}.Lb.sorted" } - // publishDir = [ - // path: { "${params.outdir}/bwa/library" }, - // mode: 'copy', - // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - // ] - // } withName: PICARD_MERGESAMFILES { ext.args = 'SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' ext.prefix = { "${meta.id}.mLb.sorted" } @@ -223,15 +202,38 @@ process { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - // withName: PICARD_MARKDUPLICATES { - // ext.args = 'ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' - // ext.prefix = { "${meta.id}.mLb.mkD.sorted" } - // publishDir = [ - // path: { "${params.outdir}/bwa/mergedLibrary" }, - // mode: 'copy', - // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - // ] - // } + withName: '.*:MARK_DUPLICATES_PICARD:PICARD_MARKDUPLICATES' { + ext.args = 'ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' + ext.prefix = { "${meta.id}.mLb.mkD.sorted" } + publishDir = [ + [ + path: { "${params.outdir}/bwa/mergedLibrary" }, + mode: 'copy', + pattern: '*metrics.txt' + ], + [ + path: { "${params.outdir}/bwa/mergedLibrary" }, + mode: 'copy', + pattern: '*.bam' + ] + ] + } + withName: '.*:MARK_DUPLICATES_PICARD:SAMTOOLS_INDEX' { + // ext.args = params.bam_csi_index ? '-c' : '' // TODO implement it + ext.prefix = { "${meta.id}.mkD.sorted" } + publishDir = [ + path: { "${params.outdir}/bwa/mergedLibrary" }, + mode: 'copy', + pattern: '*.{bai,csi}' + ] + } + withName: '.*:MARK_DUPLICATES_PICARD:BAM_STATS_SAMTOOLS:.*' { + publishDir = [ + path: { "${params.outdir}/bwa/samtools_stats" }, + mode: 'copy', + pattern: '*.{stats,flagstat,idxstats}' + ] + } withName: BAM_FILTER { ext.prefix = { "${meta.id}.mLb.flT.sorted" } publishDir = [ @@ -249,8 +251,6 @@ process { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - - // withName: SAMTOOLS_SORT_FILTER { //FILTER_BAM_BAMTOOLS //delete withName: 'NFCORE_CHIPSEQ:CHIPSEQ:FILTER_BAM_BAMTOOLS:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ @@ -259,7 +259,6 @@ process { pattern: '*.{bai,csi}' ] } - withName: 'NFCORE_CHIPSEQ:CHIPSEQ:FILTER_BAM_BAMTOOLS:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ @@ -268,7 +267,6 @@ process { pattern: "*.bam" ] } - withName: 'NFCORE_CHIPSEQ:CHIPSEQ:FILTER_BAM_BAMTOOLS:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:.*' { ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ @@ -277,7 +275,6 @@ process { pattern: "*.{stats,flagstat,idxstats}" ] } - withName: PICARD_COLLECTMULTIPLEMETRICS { ext.args = 'VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' ext.prefix = { "${meta.id}.mLb.clN.sorted" } @@ -370,47 +367,6 @@ process { // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } // ] // } - -// } - -// if (!params.skip_alignment && !params.skip_markduplicates) { -// process { - // MARK_DUPLICATES_PICARD - withName: '.*:MARK_DUPLICATES_PICARD:PICARD_MARKDUPLICATES' { - ext.args = 'ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' - ext.prefix = { "${meta.id}.mLb.mkD.sorted" } - publishDir = [ - [ - path: { "${params.outdir}/bwa/mergedLibrary" }, - mode: 'copy', - pattern: '*metrics.txt' - ], - [ - path: { "${params.outdir}/bwa/mergedLibrary" }, - mode: 'copy', - pattern: '*.bam' - ] - ] - } - - withName: '.*:MARK_DUPLICATES_PICARD:SAMTOOLS_INDEX' { - // ext.args = params.bam_csi_index ? '-c' : '' // TODO implement it - ext.prefix = { "${meta.id}.mkD.sorted" } - publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary" }, - mode: 'copy', - pattern: '*.{bai,csi}' - ] - } - - withName: '.*:MARK_DUPLICATES_PICARD:BAM_STATS_SAMTOOLS:.*' { - publishDir = [ - path: { "${params.outdir}/bwa/samtools_stats" }, - mode: 'copy', - pattern: '*.{stats,flagstat,idxstats}' - ] - } -// } } // here @@ -502,7 +458,6 @@ if (params.macs_gsize) { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - withName: SUBREAD_FEATURECOUNTS { ext.args = '-F SAF -O --fracOverlap 0.2' publishDir = [ @@ -517,6 +472,21 @@ if (params.macs_gsize) { } } +if (!params.skip_igv) { + process { + withName: IGV { + publishDir = [ + path: { [ + "${params.outdir}/igv", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + } +} + if (!params.skip_multiqc) { process { withName: MULTIQC { @@ -532,152 +502,3 @@ if (!params.skip_multiqc) { } } } - -// params { -// modules { -// 'gffread' { -// args = '--keep-exon-attrs -F -T' -// publish_dir = 'genome' -// } -// 'bwa_index' { -// args = "-a bwtsw" -// publish_dir = "genome/index" -// } -// 'fastqc' { -// args = "--quiet" -// } -// 'trimgalore' { -// args = "--fastqc" -// } -// 'bwa_mem' { -// args = "-M" -// args2 = "-h -F 0x0100 -O BAM" -// publish_dir = "bwa/library" -// suffix = ".Lb" -// } -// 'samtools_sort_lib' { // ALIGN_BWA_MEM -// publish_dir = "bwa/library" -// suffix = ".Lb.sorted" -// } -// 'picard_mergesamfiles' { -// args = "SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" -// publish_dir = "bwa/mergedLibrary" -// suffix = ".mLb.sorted" -// } -// 'picard_markduplicates' { -// args = "--ASSUME_SORTED true --REMOVE_DUPLICATES false --VALIDATION_STRINGENCY LENIENT --TMP_DIR tmp" -// publish_dir = "bwa/mergedLibrary" -// suffix = ".mLb.mkD.sorted" -// } -// 'picard_markduplicates_samtools' { //MARK_DUPLICATES_PICARD -// args = '' -// suffix = ".mLb.mkD.sorted" -// publish_files = ['bai':'', 'stats':'samtools_stats', 'flagstat':'samtools_stats', 'idxstats':'samtools_stats'] -// publish_dir = "bwa/mergedLibrary" -// } -// 'bam_filter' { -// publish_dir = "bwa/mergedLibrary" -// suffix = ".mLb.flT.sorted" -// } -// 'bam_remove_orphans' { -// args = "--only_fr_pairs" -// publish_dir = "bwa/mergedLibrary" -// suffix = ".mLb.clN" -// } -// 'samtools_sort_filter' { //FILTER_BAM_BAMTOOLS -// publish_dir = "bwa/mergedLibrary" -// suffix = ".mLb.clN.sorted" -// } -// 'picard_collectmultiplemetrics' { -// args = "VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp" -// publish_dir = "bwa/mergedLibrary/picard_metrics" -// suffix = ".mLb.clN.sorted" -// } -// 'preseq_lcextrap' { -// args = "-verbose -bam -seed 1" -// publish_dir = "bwa/mergedLibrary/preseq" -// suffix = ".mLb.clN" -// } -// 'phantompeakqualtools' { -// publish_dir = "bwa/mergedLibrary/phantompeakqualtools" -// suffix = ".mLb.clN" -// } -// 'multiqc_custom_phantompeakqualtools' { -// publish_dir = "multiqc" -// publish_files = [:] -// } -// 'bedtools_genomecov' { -// publish_dir = "bwa/mergedLibrary/bigwig" -// suffix = ".mLb.clN" -// } -// 'ucsc_bedgraphtobigwig' { -// publish_dir = "bwa/mergedLibrary/bigwig" -// suffix = ".mLb.clN" -// } -// 'deeptools_computematrix' { -// args = "scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels" -// publish_dir = "bwa/mergedLibrary/deeptools" -// suffix = ".mLb.clN" -// } -// 'deeptools_plotprofile' { -// publish_dir = "bwa/mergedLibrary/deeptools" -// suffix = ".mLb.clN" -// } -// 'deeptools_plotheatmap' { -// publish_dir = "bwa/mergedLibrary/deeptools" -// suffix = ".mLb.clN" -// } -// 'deeptools_plotfingerprint' { -// args = "--skipZeros" -// publish_dir = "bwa/mergedLibrary/deeptools" -// suffix = ".mLb.clN" -// } -// 'macs2_callpeak' { -// args = "--keep-dup all" -// publish_dir = "bwa/mergedLibrary/macs2" -// } -// 'frip_score' { -// args = "-bed -c -f 0.20" -// publish_dir = "frip" -// publish_files = [:] -// } -// 'multiqc_custom_peaks' { -// publish_dir = "multiqc" -// publish_files = [:] -// } -// 'plot_macs2_qc' { -// args = "-o ./ -p macs2_peak" -// publish_dir = "bwa/mergedLibrary/macs2" -// } -// 'homer_annotatepeaks_macs2' { -// args = "-gid" -// publish_dir = "bwa/mergedLibrary/macs2" -// suffix = "_peaks" -// } -// 'plot_homer_annotatepeaks' { -// args = "-o ./ -p macs2_annotatePeaks" -// publish_dir = "bwa/mergedLibrary/macs2" -// } -// 'macs2_consensus' { -// publish_dir = "bwa/mergedLibrary/macs2" -// publish_by_id = true -// } -// 'homer_annotatepeaks_consensus' { -// args = "-gid" -// publish_dir = "bwa/mergedLibrary/macs2" -// publish_by_id = true -// suffix = ".consensus_peaks" -// } -// 'subread_featurecounts' { -// args = "-F SAF -O --fracOverlap 0.2" -// publish_dir = "bwa/mergedLibrary/macs2" -// } -// 'deseq2_featurecounts' { -// publish_dir = "bwa/mergedLibrary/macs2" -// } -// 'multiqc' { -// args = '' -// publish_dir = "multiqc" -// } -// } -// } diff --git a/modules/local/igv.nf b/modules/local/igv.nf index e70ccfa8e..0cf01511a 100644 --- a/modules/local/igv.nf +++ b/modules/local/igv.nf @@ -10,12 +10,12 @@ process IGV { input: path fasta - path ("${bigwig_options.publish_dir}/*") - path ("${peak_options.publish_dir}/*") - path ("${consensus_options.publish_dir}/*") - val bigwig_options - val peak_options - val consensus_options + path ("${bigwig_publish_dir}/*") + path ("${peak_publish_dir}/*") + path ("${consensus_publish_dir}/*") + val bigwig_publish_dir + val peak_publish_dir + val consensus_publish_dir // path differential_peaks from ch_macs_consensus_deseq_comp_igv.collect().ifEmpty([]) output: diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index cda46b955..dcd502cae 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -494,17 +494,22 @@ workflow CHIPSEQ { // // Create IGV session // - // TODO rethink how files are passed - // IGV ( - // PREPARE_GENOME.out.fasta, - // UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), - // MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), - // MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), - // params.modules['ucsc_bedgraphtobigwig'], - // params.modules['macs2_callpeak'], - // params.modules['macs2_consensus'] - // ) - // ch_versions = ch_versions.mix(IGV.out.versions) + if (!params.skip_igv) { + IGV ( + PREPARE_GENOME.out.fasta, + UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), + MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), + MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), + "bwa/mergedLibrary/bigwig", + { ["bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + { ["bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') } + ) + ch_versions = ch_versions.mix(IGV.out.versions) + } // // MODULE: Pipeline reporting From 87eefc4074aa3a95d8f2b800375c4309aeb9308a Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 21 Dec 2021 12:41:11 +0100 Subject: [PATCH 263/538] Remove vestiges from the old syntax --- subworkflows/local/filter_bam_bamtools.nf | 13 +-- subworkflows/nf-core/align_bwa_mem.nf | 9 +-- subworkflows/nf-core/bam_sort_samtools.nf | 10 +-- subworkflows/nf-core/bam_stats_samtools.nf | 8 +- subworkflows/nf-core/fastqc_trimgalore.nf | 7 +- .../nf-core/mark_duplicates_picard.nf | 9 +-- workflows/chipseq.nf | 80 ++----------------- 7 files changed, 24 insertions(+), 112 deletions(-) diff --git a/subworkflows/local/filter_bam_bamtools.nf b/subworkflows/local/filter_bam_bamtools.nf index 1ab9fec7f..8472ce5d0 100644 --- a/subworkflows/local/filter_bam_bamtools.nf +++ b/subworkflows/local/filter_bam_bamtools.nf @@ -1,15 +1,10 @@ /* * Filter BAM file */ -// params.bam_filter_options = [:] -// params.bam_remove_orphans_options = [:] -// params.samtools_sort_options = [:] -// params.samtools_index_options = [:] -// params.samtools_stats_options = [:] - -include { BAM_FILTER } from '../../modules/local/bam_filter' //addParams( options: params.bam_filter_options ) -include { BAM_REMOVE_ORPHANS } from '../../modules/local/bam_remove_orphans' //addParams( options: params.bam_remove_orphans_options ) -include { BAM_SORT_SAMTOOLS } from '../nf-core/bam_sort_samtools' //addParams( sort_options: params.samtools_sort_options, index_options: params.samtools_index_options, stats_options: params.samtools_stats_options ) + +include { BAM_FILTER } from '../../modules/local/bam_filter' +include { BAM_REMOVE_ORPHANS } from '../../modules/local/bam_remove_orphans' +include { BAM_SORT_SAMTOOLS } from '../nf-core/bam_sort_samtools' workflow FILTER_BAM_BAMTOOLS { take: diff --git a/subworkflows/nf-core/align_bwa_mem.nf b/subworkflows/nf-core/align_bwa_mem.nf index 0f80487fa..297fd3504 100644 --- a/subworkflows/nf-core/align_bwa_mem.nf +++ b/subworkflows/nf-core/align_bwa_mem.nf @@ -2,13 +2,8 @@ * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats */ -// params.bwa_mem_options = [:] -// params.samtools_sort_options = [:] -// params.samtools_index_options = [:] -// params.samtools_stats_options = [:] - -include { BWA_MEM } from '../../modules/nf-core/modules/bwa/mem/main' //addParams( options: params.bwa_mem_options ) -include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' //addParams( sort_options: params.samtools_sort_options, index_options: params.samtools_index_options, stats_options: params.samtools_stats_options ) +include { BWA_MEM } from '../../modules/nf-core/modules/bwa/mem/main' +include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' workflow ALIGN_BWA_MEM { take: diff --git a/subworkflows/nf-core/bam_sort_samtools.nf b/subworkflows/nf-core/bam_sort_samtools.nf index 9e1ce9dbb..418e14cc0 100644 --- a/subworkflows/nf-core/bam_sort_samtools.nf +++ b/subworkflows/nf-core/bam_sort_samtools.nf @@ -2,13 +2,9 @@ * Sort, index BAM file and run samtools stats, flagstat and idxstats */ -// params.sort_options = [:] -// params.index_options = [:] -// params.stats_options = [:] - -include { SAMTOOLS_SORT } from '../../modules/nf-core/modules/samtools/sort/main' //addParams( options: params.sort_options ) -include { SAMTOOLS_INDEX } from '../../modules/nf-core/modules/samtools/index/main' //addParams( options: params.index_options ) -include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' //addParams( options: params.stats_options ) +include { SAMTOOLS_SORT } from '../../modules/nf-core/modules/samtools/sort/main' +include { SAMTOOLS_INDEX } from '../../modules/nf-core/modules/samtools/index/main' +include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' workflow BAM_SORT_SAMTOOLS { take: diff --git a/subworkflows/nf-core/bam_stats_samtools.nf b/subworkflows/nf-core/bam_stats_samtools.nf index fe26629a6..89a7338f6 100644 --- a/subworkflows/nf-core/bam_stats_samtools.nf +++ b/subworkflows/nf-core/bam_stats_samtools.nf @@ -2,11 +2,9 @@ * Run SAMtools stats, flagstat and idxstats */ -//params.options = [:] - -include { SAMTOOLS_STATS } from '../../modules/nf-core/modules/samtools/stats/main' //addParams( options: params.options ) -include { SAMTOOLS_IDXSTATS } from '../../modules/nf-core/modules/samtools/idxstats/main' //addParams( options: params.options ) -include { SAMTOOLS_FLAGSTAT } from '../../modules/nf-core/modules/samtools/flagstat/main' //addParams( options: params.options ) +include { SAMTOOLS_STATS } from '../../modules/nf-core/modules/samtools/stats/main' +include { SAMTOOLS_IDXSTATS } from '../../modules/nf-core/modules/samtools/idxstats/main' +include { SAMTOOLS_FLAGSTAT } from '../../modules/nf-core/modules/samtools/flagstat/main' workflow BAM_STATS_SAMTOOLS { take: diff --git a/subworkflows/nf-core/fastqc_trimgalore.nf b/subworkflows/nf-core/fastqc_trimgalore.nf index acaab9fd5..966541cad 100644 --- a/subworkflows/nf-core/fastqc_trimgalore.nf +++ b/subworkflows/nf-core/fastqc_trimgalore.nf @@ -2,11 +2,8 @@ // Read QC and trimming // -params.fastqc_options = [:] -params.trimgalore_options = [:] - -include { FASTQC } from '../../modules/nf-core/modules/fastqc/main' addParams( options: params.fastqc_options ) -include { TRIMGALORE } from '../../modules/nf-core/modules/trimgalore/main' addParams( options: params.trimgalore_options ) +include { FASTQC } from '../../modules/nf-core/modules/fastqc/main' +include { TRIMGALORE } from '../../modules/nf-core/modules/trimgalore/main' workflow FASTQC_TRIMGALORE { take: diff --git a/subworkflows/nf-core/mark_duplicates_picard.nf b/subworkflows/nf-core/mark_duplicates_picard.nf index adaa2911a..33e88bf58 100644 --- a/subworkflows/nf-core/mark_duplicates_picard.nf +++ b/subworkflows/nf-core/mark_duplicates_picard.nf @@ -1,13 +1,10 @@ /* * Picard MarkDuplicates, sort, index BAM file and run samtools stats, flagstat and idxstats */ -// params.markduplicates_options = [:] // TODO -// params.samtools_index_options = [:] // TODO -// params.samtools_stats_options = [:] // TODO -include { PICARD_MARKDUPLICATES } from '../../modules/nf-core/modules/picard/markduplicates/main' //addParams( options: params.markduplicates_options ) -include { SAMTOOLS_INDEX } from '../../modules/nf-core/modules/samtools/index/main' //addParams( options: params.samtools_index_options ) -include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' //addParams( options: params.samtools_stats_options ) +include { PICARD_MARKDUPLICATES } from '../../modules/nf-core/modules/picard/markduplicates/main' +include { SAMTOOLS_INDEX } from '../../modules/nf-core/modules/samtools/index/main' +include { BAM_STATS_SAMTOOLS } from './bam_stats_samtools' workflow MARK_DUPLICATES_PICARD { take: diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index dcd502cae..de4419bd9 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -61,29 +61,13 @@ ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering ======================================================================================== */ -// Don't overwrite global params.modules, create a copy instead and use that within the main script. -// def modules = params.modules.clone() - -// def plot_macs2_qc_options = modules['plot_macs2_qc'] -// plot_macs2_qc_options.publish_dir += "/$peakType/qc" - -// def plot_homer_annotatepeaks_options = modules['plot_homer_annotatepeaks'] -// plot_homer_annotatepeaks_options.publish_dir += "/$peakType/qc" - -// def macs2_consensus_options = modules['macs2_consensus'] -// macs2_consensus_options.publish_dir += "/$peakType/qc" - -// def multiqc_options = modules['multiqc'] -// multiqc_options.args += params.multiqc_title ? Utils.joinModuleArgs(["--title \"$params.multiqc_title\""]) : '' -// multiqc_options.publish_dir += "/$peakType" - include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_genomecov' include { FRIP_SCORE } from '../modules/local/frip_score' include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' //include { DESEQ2_QC } from '../modules/local/deseq2_qc' -include { IGV } from '../modules/local/igv' //addParams( options: [:] ) +include { IGV } from '../modules/local/igv' include { MULTIQC } from '../modules/local/multiqc' include { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS } from '../modules/local/multiqc_custom_phantompeakqualtools' include { MULTIQC_CUSTOM_PEAKS } from '../modules/local/multiqc_custom_peaks' @@ -91,30 +75,9 @@ include { MULTIQC_CUSTOM_PEAKS } from '../modules/local/multiqc_c // // SUBWORKFLOW: Consisting of a mix of local and nf-core/modules // - -// def publish_genome_options = params.save_reference ? [publish_dir: 'genome'] : [publish_files: false] -// def publish_index_options = params.save_reference ? [publish_dir: 'genome/index'] : [publish_files: false] - -// def gffread_options = modules['gffread'] -// if (!params.save_reference) { gffread_options['publish_files'] = false } - -// def bwa_index_options = modules['bwa_index'] -// if (!params.save_reference) { bwa_index_options['publish_files'] = false } - -include { INPUT_CHECK } from '../subworkflows/local/input_check' //addParams( options: [:] ) -include { PREPARE_GENOME } from '../subworkflows/local/prepare_genome' //addParams( -// genome_options : publish_genome_options, -// index_options : publish_index_options, -// gffread_options : gffread_options, -// bwa_index_options : bwa_index_options -// ) -include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' //addParams( -// bam_filter_options : modules['bam_filter'], -// bam_remove_orphans_options: modules['bam_remove_orphans'], -// samtools_sort_options : modules['samtools_sort_filter'], -// samtools_index_options : modules['samtools_sort_filter'], -// samtools_stats_options : modules['samtools_sort_filter'] -// ) +include { INPUT_CHECK } from '../subworkflows/local/input_check' +include { PREPARE_GENOME } from '../subworkflows/local/prepare_genome' +include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' /* ======================================================================================== @@ -126,25 +89,6 @@ include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' // MODULE: Installed directly from nf-core/modules // -// def deeptools_plotfingerprint_options = modules['deeptools_plotfingerprint'] // AQUI see here https://github.com/nf-core/rnaseq/blob/492f6e0e678b4a5fcdf26b3a60834efb23265889/conf/modules.config#L83 -// deeptools_plotfingerprint_options.args += " --numberOfSamples $params.fingerprint_bins" - -// def macs2_callpeak_options = modules['macs2_callpeak'] -// macs2_callpeak_options.args += params.narrow_peak ? '' : Utils.joinModuleArgs(['--broad', "--broad-cutoff ${params.broad_cutoff}"]) -// macs2_callpeak_options.args += params.save_macs_pileup ? Utils.joinModuleArgs(['--bdg', '--SPMR']) : '' -// macs2_callpeak_options.args += params.macs_fdr ? Utils.joinModuleArgs(["--qvalue ${params.macs_fdr}"]) : '' -// macs2_callpeak_options.args += params.macs_pvalue ? Utils.joinModuleArgs(["--pvalue ${params.macs_pvalue}"]) : '' -// macs2_callpeak_options['publish_dir'] += "/$peakType" - -// def homer_annotatepeaks_macs2_options = modules['homer_annotatepeaks_macs2'] -// homer_annotatepeaks_macs2_options['publish_dir'] += "/$peakType" - -// def homer_annotatepeaks_consensus_options = modules['homer_annotatepeaks_consensus'] -// homer_annotatepeaks_consensus_options['publish_dir'] += "/$peakType/consensus" - -// def subread_featurecounts_options = modules['subread_featurecounts'] -// subread_featurecounts_options['publish_dir'] += "/$peakType/consensus" - include { PICARD_MERGESAMFILES } from '../modules/nf-core/modules/picard/mergesamfiles/main' include { PICARD_COLLECTMULTIPLEMETRICS } from '../modules/nf-core/modules/picard/collectmultiplemetrics/main' include { PRESEQ_LCEXTRAP } from '../modules/nf-core/modules/preseq/lcextrap/main' @@ -165,16 +109,9 @@ include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../module // SUBWORKFLOW: Consisting entirely of nf-core/modules // -// def trimgalore_options = modules['trimgalore'] -// trimgalore_options.args += params.trim_nextseq > 0 ? Utils.joinModuleArgs(["--nextseq ${params.trim_nextseq}"]) : '' -// if (params.save_trimmed) { trimgalore_options.publish_files.put('fq.gz','') } - - -// def picard_markduplicates_samtools = modules['picard_markduplicates_samtools'] - -include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' //addParams( fastqc_options: modules['fastqc'], trimgalore_options: trimgalore_options ) -include { ALIGN_BWA_MEM } from '../subworkflows/nf-core/align_bwa_mem' //addParams( bwa_mem_options: modules['bwa_mem'], samtools_sort_options: modules['samtools_sort_lib'], samtools_index_options: modules['samtools_sort_lib'], samtools_stats_options: modules['samtools_sort_lib'] ) -include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' //addParams( markduplicates_options: modules['picard_markduplicates'], samtools_index_options: picard_markduplicates_samtools, samtools_stats_options: picard_markduplicates_samtools ) +include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' +include { ALIGN_BWA_MEM } from '../subworkflows/nf-core/align_bwa_mem' +include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' /* ======================================================================================== @@ -217,9 +154,6 @@ workflow CHIPSEQ { // // SUBWORKFLOW: Map reads & BAM QC // - // score = params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' - // params.modules['bwa_mem'].args += score - ALIGN_BWA_MEM ( FASTQC_TRIMGALORE.out.reads, PREPARE_GENOME.out.bwa_index From 59c4b23666f9e48d8596f7a89f866d6ef10224ff Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 21 Dec 2021 20:38:06 +0100 Subject: [PATCH 264/538] Add back skip parameters --- conf/modules.config | 285 ++++++++++++++++++++++++------------------- workflows/chipseq.nf | 251 +++++++++++++++++++------------------ 2 files changed, 295 insertions(+), 241 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 522482121..88dd3900a 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -275,24 +275,6 @@ process { pattern: "*.{stats,flagstat,idxstats}" ] } - withName: PICARD_COLLECTMULTIPLEMETRICS { - ext.args = 'VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' - ext.prefix = { "${meta.id}.mLb.clN.sorted" } - publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/picard_metrics" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - withName: PRESEQ_LCEXTRAP { - ext.args = '-verbose -bam -seed 1' - ext.prefix = { "${meta.id}.mLb.clN" } - publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/preseq" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } withName: PHANTOMPEAKQUALTOOLS { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ @@ -323,153 +305,210 @@ process { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - withName: DEEPTOOLS_COMPUTEMATRIX { - ext.args = 'scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels' - ext.prefix = { "${meta.id}.mLb.clN" } - publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - withName: DEEPTOOLS_PLOTPROFILE { - ext.prefix = { "${meta.id}.mLb.clN" } - publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - withName: DEEPTOOLS_PLOTHEATMAP { - ext.prefix = { "${meta.id}.mLb.clN" } - publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - withName: DEEPTOOLS_PLOTFINGERPRINT { - ext.args = [ - '--skipZeros', - "--numberOfSamples $params.fingerprint_bins" - ].join(' ').trim() - ext.prefix = { "${meta.id}.mLb.clN" } - publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - // withName: DESEQ2_FEATURECOUNTS { - // publishDir = [ - // path: { "${params.outdir}/bwa/mergedLibrary/macs2" }, - // mode: 'copy', - // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - // ] - // } } -// here -if (params.macs_gsize) { +if (!params.skip_picard_metrics) { process { - withName: MACS2_CALLPEAK { - ext.args = [ - '--keep-dup all', - params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}", - params.save_macs_pileup ? '--bdg --SPMR' : '', - params.macs_fdr ? "--pvalue ${params.macs_pvalue}" : '', - params.macs_pvalue ? "--qvalue ${params.macs_fdr}" : '' - ].join(' ').trim() + withName: PICARD_COLLECTMULTIPLEMETRICS { + ext.args = 'VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' + ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ - path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + path: { "${params.outdir}/bwa/mergedLibrary/picard_metrics" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - withName: FRIP_SCORE { - ext.args = '-bed -c -f 0.20' + } +} + +if (!params.skip_preseq) { + process { + withName: PRESEQ_LCEXTRAP { + ext.args = '-verbose -bam -seed 1' + ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/frip" }, - enable: false + path: { "${params.outdir}/bwa/mergedLibrary/preseq" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - withName: MULTIQC_CUSTOM_PEAKS { + } +} + +if (!params.skip_plot_profile) { + process { + withName: DEEPTOOLS_COMPUTEMATRIX { + ext.args = 'scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels' + ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/multiqc" }, - enabled: false + path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - withName: PLOT_MACS2_QC { - ext.args = '-o ./ -p macs2_peak' + withName: DEEPTOOLS_PLOTPROFILE { + ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - withName: HOMER_ANNOTATEPEAKS_MACS2 { - ext.args = '-gid' - // ext.prefix = 'peaks' + withName: DEEPTOOLS_PLOTHEATMAP { + ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - withName: PLOT_HOMER_ANNOTATEPEAKS { - ext.args = '-o ./ -p macs2_annotatePeaks' + } +} + +if (!params.skip_plot_fingerprint) { + process { + withName: DEEPTOOLS_PLOTFINGERPRINT { + ext.args = [ + '--skipZeros', + "--numberOfSamples $params.fingerprint_bins" + ].join(' ').trim() + ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - withName: MACS2_CONSENSUS { + } +} + +if (params.macs_gsize) { + process { + withName: MACS2_CALLPEAK { + ext.args = [ + '--keep-dup all', + params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}", + params.save_macs_pileup ? '--bdg --SPMR' : '', + params.macs_fdr ? "--pvalue ${params.macs_pvalue}" : '', + params.macs_pvalue ? "--qvalue ${params.macs_fdr}" : '' + ].join(' ').trim() publishDir = [ path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - withName: HOMER_ANNOTATEPEAKS_CONSENSUS { - ext.args = '-gid' - ext.prefix = 'consensus_peaks' + withName: FRIP_SCORE { + ext.args = '-bed -c -f 0.20' publishDir = [ - path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + path: { "${params.outdir}/frip" }, + enable: false ] } - withName: SUBREAD_FEATURECOUNTS { - ext.args = '-F SAF -O --fracOverlap 0.2' + withName: MULTIQC_CUSTOM_PEAKS { publishDir = [ - path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + path: { "${params.outdir}/multiqc" }, + enabled: false ] } } + + if (!params.skip_peak_annotation && !params.skip_peak_qc) { + process { + withName: PLOT_MACS2_QC { + ext.args = '-o ./ -p macs2_peak' + publishDir = [ + path: { [ + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: HOMER_ANNOTATEPEAKS_MACS2 { + ext.args = '-gid' + // ext.prefix = 'peaks' + publishDir = [ + path: { [ + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: PLOT_HOMER_ANNOTATEPEAKS { + ext.args = '-o ./ -p macs2_annotatePeaks' + publishDir = [ + path: { [ + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + } + } + + if (!params.skip_consensus_peaks) { + process { + withName: MACS2_CONSENSUS { + publishDir = [ + path: { [ + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: SUBREAD_FEATURECOUNTS { + ext.args = '-F SAF -O --fracOverlap 0.2' + publishDir = [ + path: { [ + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + } + } + + if (!params.skip_peak_annotation) { + process { + withName: HOMER_ANNOTATEPEAKS_CONSENSUS { + ext.args = '-gid' + ext.prefix = 'consensus_peaks' + publishDir = [ + path: { [ + "${params.outdir}/bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + } + } + + // if (!params.skip_diff_analysis) { + // process { + // withName: DESEQ2_FEATURECOUNTS { + // publishDir = [ + // path: { "${params.outdir}/bwa/mergedLibrary/macs2" }, + // mode: 'copy', + // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + // ] + // } + // } + // } } if (!params.skip_igv) { diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index de4419bd9..45901d10a 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -201,19 +201,23 @@ workflow CHIPSEQ { // // MODULE: Post alignment QC // - PICARD_COLLECTMULTIPLEMETRICS ( - FILTER_BAM_BAMTOOLS.out.bam, - PREPARE_GENOME.out.fasta - ) - ch_versions = ch_versions.mix(PICARD_COLLECTMULTIPLEMETRICS.out.versions.first()) + if (!params.skip_picard_metrics) { + PICARD_COLLECTMULTIPLEMETRICS ( + FILTER_BAM_BAMTOOLS.out.bam, + PREPARE_GENOME.out.fasta + ) + ch_versions = ch_versions.mix(PICARD_COLLECTMULTIPLEMETRICS.out.versions.first()) + } // // MODULE: Library coverage // - PRESEQ_LCEXTRAP ( - FILTER_BAM_BAMTOOLS.out.bam - ) - ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions.first()) + if (!params.skip_preseq) { + PRESEQ_LCEXTRAP ( + FILTER_BAM_BAMTOOLS.out.bam + ) + ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions.first()) + } // // MODULE: Strand cross-correlation @@ -250,21 +254,23 @@ workflow CHIPSEQ { // // MODULE: Coverage plots // - DEEPTOOLS_COMPUTEMATRIX ( - UCSC_BEDGRAPHTOBIGWIG.out.bigwig, - PREPARE_GENOME.out.gene_bed - ) - ch_versions = ch_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first()) + if (!params.skip_plot_profile) { + DEEPTOOLS_COMPUTEMATRIX ( + UCSC_BEDGRAPHTOBIGWIG.out.bigwig, + PREPARE_GENOME.out.gene_bed + ) + ch_versions = ch_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first()) - DEEPTOOLS_PLOTPROFILE ( - DEEPTOOLS_COMPUTEMATRIX.out.matrix - ) - ch_versions = ch_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first()) + DEEPTOOLS_PLOTPROFILE ( + DEEPTOOLS_COMPUTEMATRIX.out.matrix + ) + ch_versions = ch_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first()) - DEEPTOOLS_PLOTHEATMAP ( - DEEPTOOLS_COMPUTEMATRIX.out.matrix - ) - ch_versions = ch_versions.mix(DEEPTOOLS_PLOTHEATMAP.out.versions.first()) + DEEPTOOLS_PLOTHEATMAP ( + DEEPTOOLS_COMPUTEMATRIX.out.matrix + ) + ch_versions = ch_versions.mix(DEEPTOOLS_PLOTHEATMAP.out.versions.first()) + } // // Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] @@ -294,17 +300,17 @@ workflow CHIPSEQ { // // plotFingerprint for IP and control together // - DEEPTOOLS_PLOTFINGERPRINT ( - ch_ip_control_bam_bai - ) - ch_versions = ch_versions.mix(DEEPTOOLS_PLOTFINGERPRINT.out.versions.first()) + if (!params.skip_plot_fingerprint) { + DEEPTOOLS_PLOTFINGERPRINT ( + ch_ip_control_bam_bai + ) + ch_versions = ch_versions.mix(DEEPTOOLS_PLOTFINGERPRINT.out.versions.first()) + } + // + // Call peaks + // if (params.macs_gsize) { - - // - // Call peaks - // - // Create channel: [ val(meta), ip_bam, control_bam ] ch_ip_control_bam_bai .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } @@ -335,94 +341,103 @@ workflow CHIPSEQ { ch_peak_count_header, ch_frip_score_header ) + if (!params.skip_peak_annotation && !params.skip_peak_qc) { + PLOT_MACS2_QC ( // plot_macs2_qc.r + MACS2_CALLPEAK.out.peak.collect{it[1]} + ) + ch_versions = ch_versions.mix(PLOT_MACS2_QC.out.versions) + + HOMER_ANNOTATEPEAKS_MACS2 ( + MACS2_CALLPEAK.out.peak, + PREPARE_GENOME.out.fasta, + PREPARE_GENOME.out.gtf + ) + ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first()) + + // HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}.view() + + PLOT_HOMER_ANNOTATEPEAKS ( + HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, + ch_peak_annotation_header, + "_peaks.annotatePeaks.txt" + ) + ch_versions = ch_versions.mix(PLOT_HOMER_ANNOTATEPEAKS.out.versions) + } - PLOT_MACS2_QC ( - MACS2_CALLPEAK.out.peak.collect{it[1]} - ) - ch_versions = ch_versions.mix(PLOT_MACS2_QC.out.versions) - - HOMER_ANNOTATEPEAKS_MACS2 ( - MACS2_CALLPEAK.out.peak, - PREPARE_GENOME.out.fasta, - PREPARE_GENOME.out.gtf - ) - ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first()) - - // HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}.view() - - PLOT_HOMER_ANNOTATEPEAKS ( - HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, - ch_peak_annotation_header, - "_peaks.annotatePeaks.txt" - ) - ch_versions = ch_versions.mix(PLOT_HOMER_ANNOTATEPEAKS.out.versions) - - // Create channel: [ meta , [ peaks ] ] - // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] - MACS2_CALLPEAK - .out - .peak - .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } - .groupTuple() - .map { - antibody, groups, peaks -> - [ - antibody, - groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, - peaks - ] } - .map { - antibody, groups, peaks -> - def meta = [:] - meta.id = antibody - meta.multiple_groups = groups.size() > 1 - meta.replicates_exist = groups.max { groups.value }.value > 1 - [ meta, peaks ] } - .set { ch_antibody_peaks } - - MACS2_CONSENSUS ( - ch_antibody_peaks - ) - ch_versions = ch_versions.mix(MACS2_CONSENSUS.out.versions) - - HOMER_ANNOTATEPEAKS_CONSENSUS ( - MACS2_CONSENSUS.out.bed, - PREPARE_GENOME.out.fasta, - PREPARE_GENOME.out.gtf - ) - ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_CONSENSUS.out.versions) - // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt - // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt - - // Create channel: [ val(meta), ip_bam ] - MACS2_CONSENSUS - .out - .saf - .map { meta, saf -> [ meta.id, meta, saf ] } - .set { ch_ip_saf } - - ch_ip_control_bam - .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } - .combine(ch_ip_saf) - .map { - it -> - fmeta = it[1] - fmeta['replicates_exist'] = it[4]['replicates_exist'] - fmeta['multiple_groups'] = it[4]['multiple_groups'] - [ fmeta, it[2], it[5] ] } - .set { ch_ip_bam } - - SUBREAD_FEATURECOUNTS ( - ch_ip_bam - ) - ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first()) - - // // DESEQ2_FEATURECOUNTS ( - // // params.modules['deseq2_featurecounts'] - // // ) - // // ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) - // // ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) - + // + // Consensus peaks analysis + // + if (!params.skip_consensus_peaks) { + // Create channel: [ meta , [ peaks ] ] + // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] + MACS2_CALLPEAK + .out + .peak + .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } + .groupTuple() + .map { + antibody, groups, peaks -> + [ + antibody, + groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, + peaks + ] } + .map { + antibody, groups, peaks -> + def meta = [:] + meta.id = antibody + meta.multiple_groups = groups.size() > 1 + meta.replicates_exist = groups.max { groups.value }.value > 1 + [ meta, peaks ] } + .set { ch_antibody_peaks } + + MACS2_CONSENSUS ( + ch_antibody_peaks + ) + ch_versions = ch_versions.mix(MACS2_CONSENSUS.out.versions) + + if (!params.skip_peak_annotation) { + HOMER_ANNOTATEPEAKS_CONSENSUS ( + MACS2_CONSENSUS.out.bed, + PREPARE_GENOME.out.fasta, + PREPARE_GENOME.out.gtf + ) + ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_CONSENSUS.out.versions) + // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt + // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt + } + + // Create channel: [ val(meta), ip_bam ] + MACS2_CONSENSUS + .out + .saf + .map { meta, saf -> [ meta.id, meta, saf ] } + .set { ch_ip_saf } + + ch_ip_control_bam + .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } + .combine(ch_ip_saf) + .map { + it -> + fmeta = it[1] + fmeta['replicates_exist'] = it[4]['replicates_exist'] + fmeta['multiple_groups'] = it[4]['multiple_groups'] + [ fmeta, it[2], it[5] ] } + .set { ch_ip_bam } + + SUBREAD_FEATURECOUNTS ( + ch_ip_bam + ) + ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first()) + + // if (!params.skip_diff_analysis) { + // // DESEQ2_FEATURECOUNTS ( + // // params.modules['deseq2_featurecounts'] + // // ) + // // ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) + // // ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) + // } + } } // From 46d9dda942a4641d2395568cd3372879bcc26c19 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 22 Dec 2021 23:07:14 +0100 Subject: [PATCH 265/538] Add missing skip parameters --- conf/modules.config | 27 +++++++-------- workflows/chipseq.nf | 78 +++++++++++++++++++++++++++----------------- 2 files changed, 60 insertions(+), 45 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 88dd3900a..de0dc2bd8 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -509,19 +509,19 @@ if (params.macs_gsize) { // } // } // } -} -if (!params.skip_igv) { - process { - withName: IGV { - publishDir = [ - path: { [ - "${params.outdir}/igv", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + if (!params.skip_igv) { + process { + withName: IGV { + publishDir = [ + path: { [ + "${params.outdir}/igv", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] + } } } } @@ -531,10 +531,7 @@ if (!params.skip_multiqc) { withName: MULTIQC { ext.args = params.multiqc_title ? "--title \"$params.multiqc_title\"" : '' publishDir = [ - path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + path: { "${params.outdir}/multiqc" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 45901d10a..e095352ff 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -201,22 +201,26 @@ workflow CHIPSEQ { // // MODULE: Post alignment QC // + ch_picardcollectmultiplemetrics_multiqc = Channel.empty() if (!params.skip_picard_metrics) { PICARD_COLLECTMULTIPLEMETRICS ( FILTER_BAM_BAMTOOLS.out.bam, PREPARE_GENOME.out.fasta ) + ch_picardcollectmultiplemetrics_multiqc = MARK_DUPLICATES_PICARD.out.metrics ch_versions = ch_versions.mix(PICARD_COLLECTMULTIPLEMETRICS.out.versions.first()) } // // MODULE: Library coverage // + ch_preseq_multiqc = Channel.empty() if (!params.skip_preseq) { PRESEQ_LCEXTRAP ( FILTER_BAM_BAMTOOLS.out.bam ) - ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions.first()) + ch_preseq_multiqc = PRESEQ_LCEXTRAP.out.ccurve + ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions.first()) } // @@ -254,6 +258,7 @@ workflow CHIPSEQ { // // MODULE: Coverage plots // + ch_deeptoolsplotprofile_multiqc = Channel.empty() if (!params.skip_plot_profile) { DEEPTOOLS_COMPUTEMATRIX ( UCSC_BEDGRAPHTOBIGWIG.out.bigwig, @@ -264,6 +269,7 @@ workflow CHIPSEQ { DEEPTOOLS_PLOTPROFILE ( DEEPTOOLS_COMPUTEMATRIX.out.matrix ) + ch_deeptoolsplotprofile_multiqc = DEEPTOOLS_PLOTPROFILE.out.table ch_versions = ch_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first()) DEEPTOOLS_PLOTHEATMAP ( @@ -300,22 +306,29 @@ workflow CHIPSEQ { // // plotFingerprint for IP and control together // + ch_deeptoolsplotfingerprint_multiqc = Channel.empty() if (!params.skip_plot_fingerprint) { DEEPTOOLS_PLOTFINGERPRINT ( ch_ip_control_bam_bai ) + ch_deeptools_plotfingerprintmultiqc = DEEPTOOLS_PLOTFINGERPRINT.out.matrix ch_versions = ch_versions.mix(DEEPTOOLS_PLOTFINGERPRINT.out.versions.first()) } // // Call peaks // + ch_custompeaks_frip_multiqc = Channel.empty() + ch_custompeaks_count_multiqc = Channel.empty() + ch_plothomerannotatepeaks_multiqc = Channel.empty() + ch_subreadfeaturecounts_multiqc = Channel.empty() if (params.macs_gsize) { // Create channel: [ val(meta), ip_bam, control_bam ] ch_ip_control_bam_bai .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } .set { ch_ip_control_bam } + MACS2_CALLPEAK ( ch_ip_control_bam, params.macs_gsize @@ -341,8 +354,11 @@ workflow CHIPSEQ { ch_peak_count_header, ch_frip_score_header ) + ch_custompeaks_frip_multiqc = MULTIQC_CUSTOM_PEAKS.out.frip + ch_custompeaks_count_multiqc = MULTIQC_CUSTOM_PEAKS.out.count + if (!params.skip_peak_annotation && !params.skip_peak_qc) { - PLOT_MACS2_QC ( // plot_macs2_qc.r + PLOT_MACS2_QC ( MACS2_CALLPEAK.out.peak.collect{it[1]} ) ch_versions = ch_versions.mix(PLOT_MACS2_QC.out.versions) @@ -361,6 +377,7 @@ workflow CHIPSEQ { ch_peak_annotation_header, "_peaks.annotatePeaks.txt" ) + ch_plothomerannotatepeaks_multiqc = PLOT_HOMER_ANNOTATEPEAKS.out.tsv ch_versions = ch_versions.mix(PLOT_HOMER_ANNOTATEPEAKS.out.versions) } @@ -428,6 +445,7 @@ workflow CHIPSEQ { SUBREAD_FEATURECOUNTS ( ch_ip_bam ) + ch_subreadfeaturecounts_multiqc = SUBREAD_FEATURECOUNTS.out.summary ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first()) // if (!params.skip_diff_analysis) { @@ -437,27 +455,27 @@ workflow CHIPSEQ { // // ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) // // ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) // } - } - } - // - // Create IGV session - // - if (!params.skip_igv) { - IGV ( - PREPARE_GENOME.out.fasta, - UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), - MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), - MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), - "bwa/mergedLibrary/bigwig", - { ["bwa/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, - { ["bwa/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') } - ) - ch_versions = ch_versions.mix(IGV.out.versions) + // + // Create IGV session + // + if (!params.skip_igv) { + IGV ( + PREPARE_GENOME.out.fasta, + UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), + MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), + MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), + "bwa/mergedLibrary/bigwig", + { ["bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + { ["bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') } + ) + ch_versions = ch_versions.mix(IGV.out.versions) + } + } } // @@ -496,20 +514,20 @@ workflow CHIPSEQ { FILTER_BAM_BAMTOOLS.out.stats.collect{it[1]}.ifEmpty([]), FILTER_BAM_BAMTOOLS.out.flagstat.collect{it[1]}.ifEmpty([]), FILTER_BAM_BAMTOOLS.out.idxstats.collect{it[1]}.ifEmpty([]), - PICARD_COLLECTMULTIPLEMETRICS.out.metrics.collect{it[1]}.ifEmpty([]), + ch_picardcollectmultiplemetrics_multiqc.collect{it[1]}.ifEmpty([]), - PRESEQ_LCEXTRAP.out.ccurve.collect{it[1]}.ifEmpty([]), - DEEPTOOLS_PLOTPROFILE.out.table.collect{it[1]}.ifEmpty([]), - DEEPTOOLS_PLOTFINGERPRINT.out.matrix.collect{it[1]}.ifEmpty([]), + ch_preseq_multiqc.collect{it[1]}.ifEmpty([]), + ch_deeptoolsplotprofile_multiqc.collect{it[1]}.ifEmpty([]), + ch_deeptoolsplotfingerprint_multiqc.collect{it[1]}.ifEmpty([]), PHANTOMPEAKQUALTOOLS.out.spp.collect{it[1]}.ifEmpty([]), MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.nsc.collect{it[1]}.ifEmpty([]), MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.rsc.collect{it[1]}.ifEmpty([]), MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.correlation.collect{it[1]}.ifEmpty([]), - MULTIQC_CUSTOM_PEAKS.out.count.collect{it[1]}.ifEmpty([]), - MULTIQC_CUSTOM_PEAKS.out.frip.collect{it[1]}.ifEmpty([]), - PLOT_HOMER_ANNOTATEPEAKS.out.tsv.collect().ifEmpty([]), - SUBREAD_FEATURECOUNTS.out.summary.collect{it[1]}.ifEmpty([]), + ch_custompeaks_frip_multiqc.collect{it[1]}.ifEmpty([]), + ch_custompeaks_count_multiqc.collect{it[1]}.ifEmpty([]), + ch_plothomerannotatepeaks_multiqc.collect{it[1]}.ifEmpty([]), + ch_subreadfeaturecounts_multiqc.collect{it[1]}.ifEmpty([]), // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) ) multiqc_report = MULTIQC.out.report.toList() From ff433252a15f9800a3ecca1f745fd60e21e62a9c Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 22 Dec 2021 23:08:49 +0100 Subject: [PATCH 266/538] Add macsGsizeWarn method --- lib/WorkflowChipseq.groovy | 24 +++++++++++++++++++++++- 1 file changed, 23 insertions(+), 1 deletion(-) diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index a24781669..99d4cbe18 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -25,7 +25,7 @@ class WorkflowChipseq { } if (!params.macs_gsize) { - macsGsizeWarn(params, log) + macsGsizeWarn(log) } } @@ -69,4 +69,26 @@ class WorkflowChipseq { System.exit(1) } } + + // + // Print a warning if both GTF and GFF have been provided + // + private static void gtfGffWarn(log) { + log.warn "=============================================================================\n" + + " Both '--gtf' and '--gff' parameters have been provided.\n" + + " Using GTF file as priority.\n" + + "===================================================================================" + } + + // + // Print a warning if macs_gsize parameter has not been provided + // + private static void macsGsizeWarn(log) { + log.warn "=============================================================================\n" + + " --macs_gsize parameter has not been provided.\n" + + " MACS2 peak-calling and differential analysis will be skipped.\n" + + " Provide '--macs_gsize genome_size' to change this behaviour.\n" + + "===================================================================================" + } + } From bc297e1b8ce1493d4d4b0a33f7c8407f4ae3fd2e Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 22 Dec 2021 23:09:18 +0100 Subject: [PATCH 267/538] Add macs_gsize to nextflow config --- lib/WorkflowChipseq.groovy | 2 +- nextflow.config | 1 + 2 files changed, 2 insertions(+), 1 deletion(-) diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index 99d4cbe18..9c8c46f8c 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -87,7 +87,7 @@ class WorkflowChipseq { log.warn "=============================================================================\n" + " --macs_gsize parameter has not been provided.\n" + " MACS2 peak-calling and differential analysis will be skipped.\n" + - " Provide '--macs_gsize genome_size' to change this behaviour.\n" + + " Provide '--macs_gsize macs2_genome_size' to change this behaviour.\n" + "===================================================================================" } diff --git a/nextflow.config b/nextflow.config index c13bae66c..e3bd51444 100644 --- a/nextflow.config +++ b/nextflow.config @@ -38,6 +38,7 @@ params { // Options: Peaks narrow_peak = false broad_cutoff = 0.1 + macs_gsize = null macs_fdr = null macs_pvalue = null min_reps_consensus = 1 From f098af0f5e39c586276ff80e383f83e3f1a3570c Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 22 Dec 2021 23:15:24 +0100 Subject: [PATCH 268/538] Update changelog --- CHANGELOG.md | 4 ++++ 1 file changed, 4 insertions(+) diff --git a/CHANGELOG.md b/CHANGELOG.md index 06cee4a48..4398da938 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -7,6 +7,10 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 ### Major enhancements +* Port pipeline to the updated Nextflow DSL2 syntax adopted on nf-core/modules + * Removed `--publish_dir_mode` as it is no longer required for the new syntax +* Bump minimum Nextflow version from `21.04.0` -> `21.10.3` +* Updated pipeline template to [nf-core/tools 2.2](https://github.com/nf-core/tools/releases/tag/2.2) * Pipeline has been re-implemented in [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) * Updated Nextflow version to `v21.04.0` (see [nextflow#572](https://github.com/nextflow-io/nextflow/issues/1964)) * Move template boilerplate code to Groovy `lib/` From 865210afa074301fad8e83429dbae93b762ea0ae Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 23 Dec 2021 08:49:05 +0100 Subject: [PATCH 269/538] Try to fix ci --- .github/workflows/ci.yml | 7 +++---- 1 file changed, 3 insertions(+), 4 deletions(-) diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 5bf66d594..9cbd18562 100755 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -50,12 +50,11 @@ jobs: name: Test workflow parameters if: ${{ github.event_name != 'push' || (github.event_name == 'push' && github.repository == 'nf-core/chipseq') }} runs-on: ubuntu-latest - env: - NXF_VER: '21.10.3' - NXF_ANSI_LOG: false strategy: matrix: - parameters: [--skip_trimming, --skip_consensus_peaks] + parameters: + - "--skip_trimming" + - "--skip_consensus_peaks" steps: - name: Check out pipeline code uses: actions/checkout@v2 From b9ecb715550f1fca6eef49169b102fa0ba1a25f2 Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Thu, 23 Dec 2021 14:18:05 +0100 Subject: [PATCH 270/538] Update .github/workflows/awsfulltest.yml Co-authored-by: Harshil Patel --- .github/workflows/awsfulltest.yml | 1 - 1 file changed, 1 deletion(-) diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index 945378313..f56327c16 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -27,4 +27,3 @@ jobs: "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-${{ github.sha }}" } profiles: test_full,aws_tower - pre_run_script: 'export NXF_VER=21.10.3' From af28f5b8a391bef080c83f765ab8abae92f5f8ca Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Thu, 23 Dec 2021 14:21:16 +0100 Subject: [PATCH 271/538] Update .github/workflows/awstest.yml Co-authored-by: Harshil Patel --- .github/workflows/awstest.yml | 1 - 1 file changed, 1 deletion(-) diff --git a/.github/workflows/awstest.yml b/.github/workflows/awstest.yml index 5404cbd32..efb79775a 100644 --- a/.github/workflows/awstest.yml +++ b/.github/workflows/awstest.yml @@ -25,4 +25,3 @@ jobs: "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-test-${{ github.sha }}" } profiles: test,aws_tower - pre_run_script: 'export NXF_VER=21.10.3' From 29efd678be8214afb0cafe6f93f3b815dde95ea7 Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Thu, 23 Dec 2021 14:21:55 +0100 Subject: [PATCH 272/538] Update CHANGELOG.md Co-authored-by: Harshil Patel --- CHANGELOG.md | 3 --- 1 file changed, 3 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 4398da938..27d0d4867 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -11,9 +11,6 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 * Removed `--publish_dir_mode` as it is no longer required for the new syntax * Bump minimum Nextflow version from `21.04.0` -> `21.10.3` * Updated pipeline template to [nf-core/tools 2.2](https://github.com/nf-core/tools/releases/tag/2.2) -* Pipeline has been re-implemented in [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) -* Updated Nextflow version to `v21.04.0` (see [nextflow#572](https://github.com/nextflow-io/nextflow/issues/1964)) -* Move template boilerplate code to Groovy `lib/` * Added `python3` shebang to appropriate scripts in `bin/` directory ### Other enhancements & fixes From d530787dada33f2ca828b2ac24ef731aeb5af95a Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Thu, 23 Dec 2021 15:29:26 +0100 Subject: [PATCH 273/538] Update modules/local/plot_homer_annotatepeaks.nf Co-authored-by: Harshil Patel --- modules/local/plot_homer_annotatepeaks.nf | 3 --- 1 file changed, 3 deletions(-) diff --git a/modules/local/plot_homer_annotatepeaks.nf b/modules/local/plot_homer_annotatepeaks.nf index 523d13252..0873e38eb 100644 --- a/modules/local/plot_homer_annotatepeaks.nf +++ b/modules/local/plot_homer_annotatepeaks.nf @@ -1,6 +1,3 @@ -/* - * Aggregated QC plots for peak-to-gene annotation - */ process PLOT_HOMER_ANNOTATEPEAKS { label 'process_medium' From fd3e77b3edc4e94ba53db6cebdcb8b5fd51c10c2 Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Thu, 23 Dec 2021 15:29:41 +0100 Subject: [PATCH 274/538] Update modules/local/plot_macs2_qc.nf Co-authored-by: Harshil Patel --- modules/local/plot_macs2_qc.nf | 3 --- 1 file changed, 3 deletions(-) diff --git a/modules/local/plot_macs2_qc.nf b/modules/local/plot_macs2_qc.nf index b47e7068b..bbbf1ce81 100644 --- a/modules/local/plot_macs2_qc.nf +++ b/modules/local/plot_macs2_qc.nf @@ -1,6 +1,3 @@ -/* - * Aggregated QC plots for peaks - */ process PLOT_MACS2_QC { label 'process_medium' From 2b36e83ea5a67f6c826f1f1735fe48bebf4ba01c Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Thu, 23 Dec 2021 15:30:31 +0100 Subject: [PATCH 275/538] Update nextflow.config Co-authored-by: Harshil Patel --- nextflow.config | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/nextflow.config b/nextflow.config index e3bd51444..15be97225 100644 --- a/nextflow.config +++ b/nextflow.config @@ -81,7 +81,7 @@ params { help = false validate_params = true show_hidden_params = false - schema_ignore_params = 'genomes,modules' + schema_ignore_params = 'genomes' enable_conda = false // Config options From 318dd3c298e582f87554bee9b33f99a92333a3a4 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 23 Dec 2021 14:48:34 +0100 Subject: [PATCH 276/538] Install custom_getchromsizes module --- conf/modules.config | 2 +- modules.json | 3 ++ modules/local/get_chrom_sizes.nf | 30 -------------- .../modules/custom/getchromsizes/main.nf | 29 ++++++++++++++ .../modules/custom/getchromsizes/meta.yml | 39 +++++++++++++++++++ subworkflows/local/prepare_genome.nf | 14 +++---- 6 files changed, 79 insertions(+), 38 deletions(-) delete mode 100644 modules/local/get_chrom_sizes.nf create mode 100644 modules/nf-core/modules/custom/getchromsizes/main.nf create mode 100644 modules/nf-core/modules/custom/getchromsizes/meta.yml diff --git a/conf/modules.config b/conf/modules.config index de0dc2bd8..10b1d336d 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -85,7 +85,7 @@ process { enabled: params.save_reference ] } - withName: GET_CHROM_SIZES { + withName: CUSTOM_GETCHROMSIZES { publishDir = [ path: { "${params.outdir}/genome" }, mode: 'copy', diff --git a/modules.json b/modules.json index f56ae271e..d5064b5dc 100644 --- a/modules.json +++ b/modules.json @@ -12,6 +12,9 @@ "custom/dumpsoftwareversions": { "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, + "custom/getchromsizes": { + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + }, "deeptools/computematrix": { "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, diff --git a/modules/local/get_chrom_sizes.nf b/modules/local/get_chrom_sizes.nf deleted file mode 100644 index 335bba2fd..000000000 --- a/modules/local/get_chrom_sizes.nf +++ /dev/null @@ -1,30 +0,0 @@ -process GET_CHROM_SIZES { - tag "$fasta" - - conda (params.enable_conda ? "bioconda::samtools=1.10" : null) - container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/samtools:1.10--h9402c20_2': - 'quay.io/biocontainers/samtools:1.10--h9402c20_2' }" - - input: - path fasta - - output: - path '*.sizes' , emit: sizes - path '*.fai' , emit: fai - path "versions.yml", emit: versions - - script: - """ - samtools \\ - faidx \\ - $fasta - - cut -f 1,2 ${fasta}.fai > ${fasta}.sizes - - cat <<-END_VERSIONS > versions.yml - "${task.process}": - samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') - END_VERSIONS - """ -} diff --git a/modules/nf-core/modules/custom/getchromsizes/main.nf b/modules/nf-core/modules/custom/getchromsizes/main.nf new file mode 100644 index 000000000..270b3f489 --- /dev/null +++ b/modules/nf-core/modules/custom/getchromsizes/main.nf @@ -0,0 +1,29 @@ +process CUSTOM_GETCHROMSIZES { + tag "$fasta" + label 'process_low' + + conda (params.enable_conda ? "bioconda::samtools=1.14" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/samtools:1.14--hb421002_0' : + 'quay.io/biocontainers/samtools:1.14--hb421002_0' }" + + input: + path fasta + + output: + path '*.sizes' , emit: sizes + path '*.fai' , emit: fai + path "versions.yml", emit: versions + + script: + def args = task.ext.args ?: '' + """ + samtools faidx $fasta + cut -f 1,2 ${fasta}.fai > ${fasta}.sizes + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + custom: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + END_VERSIONS + """ +} diff --git a/modules/nf-core/modules/custom/getchromsizes/meta.yml b/modules/nf-core/modules/custom/getchromsizes/meta.yml new file mode 100644 index 000000000..eb1db4bb0 --- /dev/null +++ b/modules/nf-core/modules/custom/getchromsizes/meta.yml @@ -0,0 +1,39 @@ +name: custom_getchromsizes +description: Generates a FASTA file of chromosome sizes and a fasta index file +keywords: + - fasta + - chromosome + - indexing +tools: + - samtools: + description: Tools for dealing with SAM, BAM and CRAM files + homepage: http://www.htslib.org/ + documentation: http://www.htslib.org/doc/samtools.html + tool_dev_url: https://github.com/samtools/samtools + doi: 10.1093/bioinformatics/btp352 + licence: ['MIT'] + +input: + - fasta: + type: file + description: FASTA file + pattern: "*.{fasta}" + +output: + - sizes: + type: file + description: File containing chromosome lengths + pattern: "*.{sizes}" + - fai: + type: file + description: FASTA index file + pattern: "*.{fai}" + - versions: + type: file + description: File containing software version + pattern: "versions.yml" + + +authors: + - "@tamara-hodgetts" + - "@chris-cheshire" diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index 620bb87a8..afdddc49e 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -8,12 +8,12 @@ include { GUNZIP as GUNZIP_GFF GUNZIP as GUNZIP_GENE_BED GUNZIP as GUNZIP_BLACKLIST } from '../../modules/nf-core/modules/gunzip/main' -include { UNTAR } from '../../modules/nf-core/modules/untar/main' -include { GFFREAD } from '../../modules/nf-core/modules/gffread/main' -include { BWA_INDEX } from '../../modules/nf-core/modules/bwa/index/main' +include { UNTAR } from '../../modules/nf-core/modules/untar/main' +include { GFFREAD } from '../../modules/nf-core/modules/gffread/main' +include { CUSTOM_GETCHROMSIZES } from '../../modules/nf-core/modules/custom/getchromsizes/main' +include { BWA_INDEX } from '../../modules/nf-core/modules/bwa/index/main' include { GTF2BED } from '../../modules/local/gtf2bed' -include { GET_CHROM_SIZES } from '../../modules/local/get_chrom_sizes' include { GENOME_BLACKLIST_REGIONS } from '../../modules/local/genome_blacklist_regions' workflow PREPARE_GENOME { @@ -96,14 +96,14 @@ workflow PREPARE_GENOME { // // Create chromosome sizes file // - ch_chrom_sizes = GET_CHROM_SIZES ( ch_fasta ).sizes - ch_versions = ch_versions.mix(GET_CHROM_SIZES.out.versions) + ch_chrom_sizes = CUSTOM_GETCHROMSIZES ( ch_fasta ).sizes + ch_versions = ch_versions.mix(CUSTOM_GETCHROMSIZES.out.versions) // // Prepare genome intervals for filtering by removing regions in blacklist file // GENOME_BLACKLIST_REGIONS ( - GET_CHROM_SIZES.out.sizes, + CUSTOM_GETCHROMSIZES.out.sizes, ch_blacklist.ifEmpty([]) ) ch_versions = ch_versions.mix(GENOME_BLACKLIST_REGIONS.out.versions) From 38769b6be5eab09c037e45f6292daaba60b4db3f Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 23 Dec 2021 15:06:58 +0100 Subject: [PATCH 277/538] Set macs_consensus files from modules.config --- conf/modules.config | 1 + modules/local/macs2_consensus.nf | 2 +- 2 files changed, 2 insertions(+), 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index 10b1d336d..f1d851233 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -458,6 +458,7 @@ if (params.macs_gsize) { if (!params.skip_consensus_peaks) { process { withName: MACS2_CONSENSUS { + ext.prefix = { "${meta.id}.consensus_peaks" } publishDir = [ path: { [ "${params.outdir}/bwa/mergedLibrary/macs2", diff --git a/modules/local/macs2_consensus.nf b/modules/local/macs2_consensus.nf index 2165ca929..7ca2c35e7 100644 --- a/modules/local/macs2_consensus.nf +++ b/modules/local/macs2_consensus.nf @@ -23,7 +23,7 @@ process MACS2_CONSENSUS { script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ if (meta.multiple_groups || meta.replicates_exist) { - def prefix = task.ext.prefix ? "${task.ext.prefix}.consensus_peaks": "${meta.id}.consensus_peaks" + def prefix = task.ext.prefix ?: "${meta.id}" def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' def mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') def collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') From 154674d9f939ee4195c0213ed2466ed996363d7f Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 23 Dec 2021 15:08:06 +0100 Subject: [PATCH 278/538] Remove line, review comment --- modules/local/multiqc.nf | 1 - 1 file changed, 1 deletion(-) diff --git a/modules/local/multiqc.nf b/modules/local/multiqc.nf index 37e41984c..4d6fe9f53 100644 --- a/modules/local/multiqc.nf +++ b/modules/local/multiqc.nf @@ -43,7 +43,6 @@ process MULTIQC { path ('macs2/annotation/*') path ('featurecounts/*') - // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) output: path "*multiqc_report.html", emit: report From aa10f83e683a162c0b69cc43bc3e16b379512cb4 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 23 Dec 2021 15:16:40 +0100 Subject: [PATCH 279/538] Add versions.yml to multiqc_custom_peaks --- modules/local/multiqc_custom_peaks.nf | 5 +++++ 1 file changed, 5 insertions(+) diff --git a/modules/local/multiqc_custom_peaks.nf b/modules/local/multiqc_custom_peaks.nf index de90cc75d..64f918c4f 100644 --- a/modules/local/multiqc_custom_peaks.nf +++ b/modules/local/multiqc_custom_peaks.nf @@ -19,5 +19,10 @@ process MULTIQC_CUSTOM_PEAKS { """ cat $peak | wc -l | awk -v OFS='\t' '{ print "${prefix}", \$1 }' | cat $peak_count_header - > ${prefix}.peak_count_mqc.tsv cat $frip_score_header $frip > ${prefix}.FRiP_mqc.tsv + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + sed: \$(echo \$(sed --version 2>&1) | sed 's/^.*GNU sed) //; s/ .*\$//') + END_VERSIONS """ } From 50c0410850b88b2278128d65118a5c283022092b Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 23 Dec 2021 15:28:41 +0100 Subject: [PATCH 280/538] Remove comment --- modules/local/multiqc_custom_phantompeakqualtools.nf | 1 - 1 file changed, 1 deletion(-) diff --git a/modules/local/multiqc_custom_phantompeakqualtools.nf b/modules/local/multiqc_custom_phantompeakqualtools.nf index 7a13f7e51..d0b1ea9cb 100644 --- a/modules/local/multiqc_custom_phantompeakqualtools.nf +++ b/modules/local/multiqc_custom_phantompeakqualtools.nf @@ -1,5 +1,4 @@ process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { - //TODO substitute with a newest tag (see https://github.com/BioContainers/containers/issues/416) conda (params.enable_conda ? "conda-forge::r-base=3.5.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? 'https://depot.galaxyproject.org/singularity/r-base:3.5.1': From 9eb3c17951b83774e42889b4797ef28ae203945f Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 23 Dec 2021 15:33:50 +0100 Subject: [PATCH 281/538] Add authors to manifest --- nextflow.config | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/nextflow.config b/nextflow.config index 15be97225..2b0941719 100644 --- a/nextflow.config +++ b/nextflow.config @@ -202,7 +202,7 @@ dag { manifest { name = 'nf-core/chipseq' - author = 'Philip Ewels' + author = 'Philip Ewels, Jose Espinosa-Carrasco, Harshil Patel' homePage = 'https://github.com/nf-core/chipseq' description = 'ChIP-seq peak-calling and differential analysis pipeline.' mainScript = 'main.nf' From 41f753c73b9806d920d848b2f4e833e4ea8682bc Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 23 Dec 2021 15:58:28 +0100 Subject: [PATCH 282/538] Update LICENSE authors to make nf-ore happy --- LICENSE | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/LICENSE b/LICENSE index 2a0f576bc..e6309f574 100644 --- a/LICENSE +++ b/LICENSE @@ -1,6 +1,6 @@ MIT License -Copyright (c) Philip Ewels +Copyright (c) Philip Ewels, Jose Espinosa-Carrasco, Harshil Patel Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal From 206469f7f027795f58970b217a23a7ce47b72712 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 23 Dec 2021 16:08:03 +0100 Subject: [PATCH 283/538] Files exists not needed anymore --- .nf-core.yml | 4 +--- 1 file changed, 1 insertion(+), 3 deletions(-) diff --git a/.nf-core.yml b/.nf-core.yml index daf3ed014..a384653dc 100644 --- a/.nf-core.yml +++ b/.nf-core.yml @@ -5,6 +5,4 @@ lint: - assets/email_template.txt - lib/NfcoreTemplate.groovy - assets/multiqc_config.yaml - files_exist: - - bin/scrape_software_versions.py - - modules/local/get_software_versions.nf + From 7abee4540d5c804125febd44d52bf375c1ed143d Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 17 Jan 2022 18:11:24 +0100 Subject: [PATCH 284/538] Add chromap_index and chromap_chromap modules --- modules.json | 6 ++ .../nf-core/modules/chromap/chromap/main.nf | 92 +++++++++++++++++++ .../nf-core/modules/chromap/chromap/meta.yml | 88 ++++++++++++++++++ modules/nf-core/modules/chromap/index/main.nf | 36 ++++++++ .../nf-core/modules/chromap/index/meta.yml | 33 +++++++ 5 files changed, 255 insertions(+) create mode 100644 modules/nf-core/modules/chromap/chromap/main.nf create mode 100644 modules/nf-core/modules/chromap/chromap/meta.yml create mode 100644 modules/nf-core/modules/chromap/index/main.nf create mode 100644 modules/nf-core/modules/chromap/index/meta.yml diff --git a/modules.json b/modules.json index d5064b5dc..06340876b 100644 --- a/modules.json +++ b/modules.json @@ -9,6 +9,12 @@ "bwa/mem": { "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, + "chromap/chromap": { + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + }, + "chromap/index": { + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + }, "custom/dumpsoftwareversions": { "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, diff --git a/modules/nf-core/modules/chromap/chromap/main.nf b/modules/nf-core/modules/chromap/chromap/main.nf new file mode 100644 index 000000000..4a7f00974 --- /dev/null +++ b/modules/nf-core/modules/chromap/chromap/main.nf @@ -0,0 +1,92 @@ +def VERSION = '0.1' // Version information not provided by tool on CLI + +process CHROMAP_CHROMAP { + tag "$meta.id" + label 'process_medium' + + conda (params.enable_conda ? "bioconda::chromap=0.1 bioconda::samtools=1.13" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:2cad7c5aa775241887eff8714259714a39baf016-0' : + 'quay.io/biocontainers/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:2cad7c5aa775241887eff8714259714a39baf016-0' }" + + input: + tuple val(meta), path(reads) + path fasta + path index + path barcodes + path whitelist + path chr_order + path pairs_chr_order + + output: + tuple val(meta), path("*.bed.gz") , optional:true, emit: bed + tuple val(meta), path("*.bam") , optional:true, emit: bam + tuple val(meta), path("*.tagAlign.gz"), optional:true, emit: tagAlign + tuple val(meta), path("*.pairs.gz") , optional:true, emit: pairs + path "versions.yml" , emit: versions + + script: + def args = task.ext.args ?: '' + def args2 = task.ext.args2 ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" + def args_list = args.tokenize() + + def file_extension = args.contains("--SAM") ? 'sam' : args.contains("--TagAlign")? 'tagAlign' : args.contains("--pairs")? 'pairs' : 'bed' + if (barcodes) { + args_list << "-b ${barcodes.join(',')}" + if (whitelist) { + args_list << "--barcode-whitelist $whitelist" + } + } + if (chr_order) { + args_list << "--chr-order $chr_order" + } + if (pairs_chr_order){ + args_list << "--pairs-natural-chr-order $pairs_chr_order" + } + def final_args = args_list.join(' ') + def compression_cmds = "gzip ${prefix}.${file_extension}" + if (args.contains("--SAM")) { + compression_cmds = """ + samtools view $args2 -@ $task.cpus -bh \\ + -o ${prefix}.bam ${prefix}.${file_extension} + rm ${prefix}.${file_extension} + """ + } + if (meta.single_end) { + """ + chromap \\ + $final_args \\ + -t $task.cpus \\ + -x $index \\ + -r $fasta \\ + -1 ${reads.join(',')} \\ + -o ${prefix}.${file_extension} + + $compression_cmds + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + chromap: $VERSION + END_VERSIONS + """ + } else { + """ + chromap \\ + $final_args \\ + -t $task.cpus \\ + -x $index \\ + -r $fasta \\ + -1 ${reads[0]} \\ + -2 ${reads[1]} \\ + -o ${prefix}.${file_extension} + + $compression_cmds + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + chromap: $VERSION + END_VERSIONS + """ + } +} diff --git a/modules/nf-core/modules/chromap/chromap/meta.yml b/modules/nf-core/modules/chromap/chromap/meta.yml new file mode 100644 index 000000000..57936c673 --- /dev/null +++ b/modules/nf-core/modules/chromap/chromap/meta.yml @@ -0,0 +1,88 @@ +name: chromap_chromap +description: | + Performs preprocessing and alignment of chromatin fastq files to + fasta reference files using chromap. +keywords: + - chromap + - alignment + - map + - fastq + - bam + - sam + - hi-c + - atac-seq + - chip-seq + - trimming + - duplicate removal +tools: + - chromap: + description: Fast alignment and preprocessing of chromatin profiles + homepage: https://github.com/haowenz/chromap + documentation: https://github.com/haowenz/chromap + tool_dev_url: https://github.com/haowenz/chromap + doi: "" + licence: ['GPL v3'] +input: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - reads: + type: file + description: | + List of input FastQ files of size 1 and 2 for single-end and paired-end data, + respectively. + - fasta: + type: file + description: | + The fasta reference file. + - index: + type: file + description: | + Chromap genome index files (*.index) + - barcodes: + type: file + description: | + Cell barcode files + - whitelist: + type: file + description: | + Cell barcode whitelist file + - chr_order: + type: file + description: | + Custom chromosome order + - pairs_chr_order: + type: file + description: | + Natural chromosome order for pairs flipping +output: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" + - bed: + type: file + description: BED file + pattern: "*.bed.gz" + - bam: + type: file + description: BAM file + pattern: "*.bam" + - tagAlign: + type: file + description: tagAlign file + pattern: "*.tagAlign.gz" + - pairs: + type: file + description: pairs file + pattern: "*.pairs.gz" + +authors: + - "@mahesh-panchal" diff --git a/modules/nf-core/modules/chromap/index/main.nf b/modules/nf-core/modules/chromap/index/main.nf new file mode 100644 index 000000000..cafeca2fb --- /dev/null +++ b/modules/nf-core/modules/chromap/index/main.nf @@ -0,0 +1,36 @@ +def VERSION = '0.1' // Version information not provided by tool on CLI + +process CHROMAP_INDEX { + tag '$fasta' + label 'process_medium' + + conda (params.enable_conda ? "bioconda::chromap=0.1 bioconda::samtools=1.13" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:2cad7c5aa775241887eff8714259714a39baf016-0' : + 'quay.io/biocontainers/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:2cad7c5aa775241887eff8714259714a39baf016-0' }" + + input: + path fasta + + output: + path "*.index" , emit: index + path "versions.yml", emit: versions + + script: + def args = task.ext.args ?: '' + def prefix = fasta.baseName + """ + chromap \\ + -i \\ + $args \\ + -t $task.cpus \\ + -r $fasta \\ + -o ${prefix}.index + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + chromap: $VERSION + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + END_VERSIONS + """ +} diff --git a/modules/nf-core/modules/chromap/index/meta.yml b/modules/nf-core/modules/chromap/index/meta.yml new file mode 100644 index 000000000..a6a18fe9d --- /dev/null +++ b/modules/nf-core/modules/chromap/index/meta.yml @@ -0,0 +1,33 @@ +name: chromap_index +description: Indexes a fasta reference genome ready for chromatin profiling. +keywords: + - index + - fasta + - genome + - reference +tools: + - chromap: + description: Fast alignment and preprocessing of chromatin profiles + homepage: https://github.com/haowenz/chromap + documentation: https://github.com/haowenz/chromap + tool_dev_url: https://github.com/haowenz/chromap + doi: "" + licence: ['GPL v3'] + +input: + - fasta: + type: file + description: Fasta reference file. + +output: + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" + - index: + type: file + description: Index file of the reference genome + pattern: "*.{index}" + +authors: + - "@mahesh-panchal" From f747b688c769c7700bcf219aaeb8ee7a7c720937 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 17 Jan 2022 18:15:46 +0100 Subject: [PATCH 285/538] Draft implementation of multiple aligner, add chromap add --- conf/modules.config | 50 +++++++++++++++++++++ nextflow.config | 3 +- subworkflows/local/prepare_genome.nf | 52 ++++++++++++++++------ subworkflows/nf-core/align_chromap.nf | 38 ++++++++++++++++ workflows/chipseq.nf | 64 +++++++++++++++++++++------ 5 files changed, 178 insertions(+), 29 deletions(-) create mode 100644 subworkflows/nf-core/align_chromap.nf diff --git a/conf/modules.config b/conf/modules.config index f1d851233..97e6ee474 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -193,6 +193,56 @@ process { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } +} + +process { + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_CHROMAP:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { + // TODO: substitute by this line when multiple aligners are implemented + // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { + ext.prefix = { "${meta.id}.Lb.sorted" } + publishDir = [ + path: { "${params.outdir}/chromap/library" }, + mode: 'copy', + pattern: "*.bam", + enabled: params.save_align_intermeds + ] + } + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_CHROMAP:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { + // TODO: substitute by this line when multiple aligners are implemented + // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { + // ext.args = params.bam_csi_index ? '-c' : '' + ext.prefix = { "${meta.id}.Lb.sorted" } + publishDir = [ + path: { "${params.outdir}/chromap/library" }, + mode: 'copy', + pattern: '*.{bai,csi}', + enabled: params.save_align_intermeds + ] + } + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_CHROMAP:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:.*' { + // TODO: substitute by this line when multiple aligners are implemented + // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_STATS' { + // ext.args = params.bam_csi_index ? '-c' : '' + ext.prefix = { "${meta.id}.Lb.sorted" } + publishDir = [ + path: { "${params.outdir}/chromap/library" }, + mode: 'copy', + pattern: "*.{stats,flagstat,idxstats}", + enabled: params.save_align_intermeds + ] + } + withName: CHROMAP_CHROMAP { + ext.args = '--preset chip' + ext.prefix = { "${meta.id}.Lb" } + publishDir = [ + path: { "${params.outdir}/chromap/library" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } +} + +process { withName: PICARD_MERGESAMFILES { ext.args = 'SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' ext.prefix = { "${meta.id}.mLb.sorted" } diff --git a/nextflow.config b/nextflow.config index 2b0941719..8f8157fc7 100644 --- a/nextflow.config +++ b/nextflow.config @@ -29,7 +29,8 @@ params { skip_trimming = false save_trimmed = false - // Options: Alignments + // Options: Alignment + aligner = 'bwa' bwa_min_score = null keep_dups = false keep_multi_map = false diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index afdddc49e..fe89b57c0 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -12,11 +12,14 @@ include { UNTAR } from '../../modules/nf-core/modules/untar/main' include { GFFREAD } from '../../modules/nf-core/modules/gffread/main' include { CUSTOM_GETCHROMSIZES } from '../../modules/nf-core/modules/custom/getchromsizes/main' include { BWA_INDEX } from '../../modules/nf-core/modules/bwa/index/main' +include { CHROMAP_INDEX } from '../../modules/nf-core/modules/chromap/index/main' include { GTF2BED } from '../../modules/local/gtf2bed' include { GENOME_BLACKLIST_REGIONS } from '../../modules/local/genome_blacklist_regions' workflow PREPARE_GENOME { + take: + prepare_tool_index // string : tool to prepare index for main: @@ -112,25 +115,46 @@ workflow PREPARE_GENOME { // Uncompress BWA index or generate from scratch if required // ch_bwa_index = Channel.empty() - if (params.bwa_index) { - if (params.bwa_index.endsWith('.tar.gz')) { - ch_bwa_index = UNTAR ( params.bwa_index ).untar - ch_versions = ch_versions.mix(UNTAR.out.versions) + if (prepare_tool_index == 'bwa') { + if (params.bwa_index) { + if (params.bwa_index.endsWith('.tar.gz')) { + ch_bwa_index = UNTAR ( params.bwa_index ).untar + ch_versions = ch_versions.mix(UNTAR.out.versions) + } else { + ch_bwa_index = file(params.bwa_index) + } } else { - ch_bwa_index = file(params.bwa_index) + ch_bwa_index = BWA_INDEX ( ch_fasta ).index + ch_versions = ch_versions.mix(BWA_INDEX.out.versions) + } + } + + // + // Uncompress CHROMAP index or generate from scratch if required + // + ch_chromap_index = Channel.empty() + if (prepare_tool_index == 'chromap') { + if (params.chromap_index) { + if (params.chromap_index.endsWith('.tar.gz')) { + ch_bwa_index = UNTAR ( params.chromap_index ).untar + ch_versions = ch_versions.mix(UNTAR.out.versions) + } else { + ch_chromap_index = file(params.chromap_index) + } + } else { + ch_chromap_index = CHROMAP_INDEX ( ch_fasta ).index + ch_versions = ch_versions.mix(CHROMAP_INDEX.out.versions) } - } else { - ch_bwa_index = BWA_INDEX ( ch_fasta ).index - ch_versions = ch_versions.mix(BWA_INDEX.out.versions) } emit: - fasta = ch_fasta // path: genome.fasta - gtf = ch_gtf // path: genome.gtf - gene_bed = ch_gene_bed // path: gene.bed - chrom_sizes = ch_chrom_sizes // path: genome.sizes - blacklist = ch_blacklist // path: blacklist.bed - bwa_index = ch_bwa_index // path: bbsplit/index/ + fasta = ch_fasta // path: genome.fasta + gtf = ch_gtf // path: genome.gtf + gene_bed = ch_gene_bed // path: gene.bed + chrom_sizes = ch_chrom_sizes // path: genome.sizes + blacklist = ch_blacklist // path: blacklist.bed + bwa_index = ch_bwa_index // path: bwa/index/ + chromap_index = ch_chromap_index // path: genome.index versions = ch_versions.ifEmpty(null) // channel: [ versions.yml ] } diff --git a/subworkflows/nf-core/align_chromap.nf b/subworkflows/nf-core/align_chromap.nf new file mode 100644 index 000000000..5afa99bc2 --- /dev/null +++ b/subworkflows/nf-core/align_chromap.nf @@ -0,0 +1,38 @@ +/* + * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats + */ + +include { CHROMAP_CHROMAP } from '../../modules/nf-core/modules/chromap/chromap/main' +include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' + +workflow ALIGN_CHROMAP { + take: + reads // channel: [ val(meta), [ reads ] ] + index // path: /path/to/index + fasta // path: /path/to/fasta + + main: + + ch_versions = Channel.empty() + + // + // Map reads with CHROMAP + // + CHROMAP_CHROMAP(reads, fasta, index, [], [], [], []) + ch_versions = ch_versions.mix(CHROMAP_CHROMAP.out.versions.first()) + + // + // Sort, index BAM file and run samtools stats, flagstat and idxstats + // + BAM_SORT_SAMTOOLS(CHROMAP_CHROMAP.out.bam) + ch_versions = ch_versions.mix(BAM_SORT_SAMTOOLS.out.versions.first()) + + emit: + bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] + bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + + versions = ch_versions // path: versions.yml +} diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index e095352ff..a483b562c 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -4,10 +4,15 @@ ======================================================================================== */ +def valid_params = [ + aligners : [ 'bwa', 'chromap' ] +] + def summary_params = NfcoreSchema.paramsSummaryMap(workflow, params) // Validate input parameters WorkflowChipseq.initialise(params, log) +// WorkflowChipseq.initialise(params, log, valid_params) // Check input path parameters to see if they exist def checkPathParamList = [ @@ -23,6 +28,10 @@ for (param in checkPathParamList) { if (param) { file(param, checkIfExists: true // Check mandatory parameters if (params.input) { ch_input = file(params.input) } else { exit 1, 'Input samplesheet not specified!' } +// Check alignment parameters +def prepareToolIndices = [] +// if (!params.skip_alignment) { prepareToolIndices << params.aligner } //DEL + // Save AWS IGenomes file containing annotation version def anno_readme = params.genomes[ params.genome ]?.readme if (anno_readme && file(anno_readme).exists()) { @@ -30,8 +39,6 @@ if (anno_readme && file(anno_readme).exists()) { file(anno_readme).copyTo("${params.outdir}/genome/") } -// def peakType = params.narrow_peak ? 'narrowPeak' : 'broadPeak' - /* ======================================================================================== CONFIG FILES @@ -111,6 +118,7 @@ include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../module include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' include { ALIGN_BWA_MEM } from '../subworkflows/nf-core/align_bwa_mem' +include { ALIGN_CHROMAP } from '../subworkflows/nf-core/align_chromap' include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' /* @@ -129,7 +137,9 @@ workflow CHIPSEQ { // // SUBWORKFLOW: Uncompress and prepare reference genome files // - PREPARE_GENOME () + PREPARE_GENOME ( + params.aligner + ) ch_versions = ch_versions.mix(PREPARE_GENOME.out.versions) // @@ -151,21 +161,47 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(FASTQC_TRIMGALORE.out.versions) + + // // SUBWORKFLOW: Map reads & BAM QC // - ALIGN_BWA_MEM ( - FASTQC_TRIMGALORE.out.reads, - PREPARE_GENOME.out.bwa_index - ) - ch_versions = ch_versions.mix(ALIGN_BWA_MEM.out.versions.first()) + ch_genome_bam = Channel.empty() + ch_genome_bam_index = Channel.empty() + ch_samtools_stats = Channel.empty() + ch_samtools_flagstat = Channel.empty() + ch_samtools_idxstats = Channel.empty() + if (params.aligner == 'bwa') { + ALIGN_BWA_MEM ( + FASTQC_TRIMGALORE.out.reads, + PREPARE_GENOME.out.bwa_index + ) + ch_genome_bam = ALIGN_BWA_MEM.out.bam + ch_genome_bam_index = ALIGN_BWA_MEM.out.bai + ch_samtools_stats = ALIGN_BWA_MEM.out.stats + ch_samtools_flagstat = ALIGN_BWA_MEM.out.flagstat + ch_samtools_idxstats = ALIGN_BWA_MEM.out.idxstats + ch_versions = ch_versions.mix(ALIGN_BWA_MEM.out.versions.first()) + } + + if (params.aligner == 'chromap') { + ALIGN_CHROMAP ( + FASTQC_TRIMGALORE.out.reads, + PREPARE_GENOME.out.chromap_index, + PREPARE_GENOME.out.fasta + ) + ch_genome_bam = ALIGN_CHROMAP.out.bam + ch_genome_bam_index = ALIGN_CHROMAP.out.bai + ch_versions = ch_versions.mix(ALIGN_CHROMAP.out.versions.first()) + } // // SUBWORKFLOW: Merge resequenced BAM files // - ALIGN_BWA_MEM - .out - .bam + // ALIGN_BWA_MEM //DEL + ch_genome_bam + // .out //DEL + // .bam //DEL .map { meta, bam -> fmeta = meta.findAll { it.key != 'read_group' } @@ -502,9 +538,9 @@ workflow CHIPSEQ { FASTQC_TRIMGALORE.out.trim_zip.collect{it[1]}.ifEmpty([]), FASTQC_TRIMGALORE.out.trim_log.collect{it[1]}.ifEmpty([]), - ALIGN_BWA_MEM.out.stats.collect{it[1]}, - ALIGN_BWA_MEM.out.flagstat.collect{it[1]}, - ALIGN_BWA_MEM.out.idxstats.collect{it[1]}, + ch_samtools_stats.collect{it[1]}.ifEmpty([]), + ch_samtools_flagstat.collect{it[1]}.ifEmpty([]), + ch_samtools_idxstats.collect{it[1]}.ifEmpty([]), MARK_DUPLICATES_PICARD.out.stats.collect{it[1]}.ifEmpty([]), MARK_DUPLICATES_PICARD.out.flagstat.collect{it[1]}.ifEmpty([]), From cb60c2ce56b2707d544a0e44eb0744e91c055f81 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 18 Jan 2022 23:30:04 +0100 Subject: [PATCH 286/538] Add bowtie/align module --- modules/nf-core/modules/bowtie2/align/main.nf | 74 +++++++++++++++++++ .../nf-core/modules/bowtie2/align/meta.yml | 51 +++++++++++++ 2 files changed, 125 insertions(+) create mode 100644 modules/nf-core/modules/bowtie2/align/main.nf create mode 100644 modules/nf-core/modules/bowtie2/align/meta.yml diff --git a/modules/nf-core/modules/bowtie2/align/main.nf b/modules/nf-core/modules/bowtie2/align/main.nf new file mode 100644 index 000000000..20b08f721 --- /dev/null +++ b/modules/nf-core/modules/bowtie2/align/main.nf @@ -0,0 +1,74 @@ +process BOWTIE2_ALIGN { + tag "$meta.id" + label 'process_high' + + conda (params.enable_conda ? 'bioconda::bowtie2=2.4.4 bioconda::samtools=1.14 conda-forge::pigz=2.6' : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/mulled-v2-ac74a7f02cebcfcc07d8e8d1d750af9c83b4d45a:4d235f41348a00533f18e47c9669f1ecb327f629-0' : + 'quay.io/biocontainers/mulled-v2-ac74a7f02cebcfcc07d8e8d1d750af9c83b4d45a:4d235f41348a00533f18e47c9669f1ecb327f629-0' }" + + input: + tuple val(meta), path(reads) + path index + val save_unaligned + + output: + tuple val(meta), path('*.bam') , emit: bam + tuple val(meta), path('*.log') , emit: log + tuple val(meta), path('*fastq.gz'), emit: fastq, optional:true + path "versions.yml" , emit: versions + + script: + def args = task.ext.args ?: '' + def args2 = task.ext.args2 ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" + if (meta.single_end) { + def unaligned = save_unaligned ? "--un-gz ${prefix}.unmapped.fastq.gz" : '' + """ + INDEX=`find -L ./ -name "*.rev.1.bt2" | sed 's/.rev.1.bt2//'` + bowtie2 \\ + -x \$INDEX \\ + -U $reads \\ + --threads $task.cpus \\ + $unaligned \\ + $args \\ + 2> ${prefix}.bowtie2.log \\ + | samtools view -@ $task.cpus $args2 -bhS -o ${prefix}.bam - + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + bowtie2: \$(echo \$(bowtie2 --version 2>&1) | sed 's/^.*bowtie2-align-s version //; s/ .*\$//') + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + pigz: \$( pigz --version 2>&1 | sed 's/pigz //g' ) + END_VERSIONS + """ + } else { + def unaligned = save_unaligned ? "--un-conc-gz ${prefix}.unmapped.fastq.gz" : '' + """ + INDEX=`find -L ./ -name "*.rev.1.bt2" | sed 's/.rev.1.bt2//'` + bowtie2 \\ + -x \$INDEX \\ + -1 ${reads[0]} \\ + -2 ${reads[1]} \\ + --threads $task.cpus \\ + $unaligned \\ + $args \\ + 2> ${prefix}.bowtie2.log \\ + | samtools view -@ $task.cpus $args2 -bhS -o ${prefix}.bam - + + if [ -f ${prefix}.unmapped.fastq.1.gz ]; then + mv ${prefix}.unmapped.fastq.1.gz ${prefix}.unmapped_1.fastq.gz + fi + if [ -f ${prefix}.unmapped.fastq.2.gz ]; then + mv ${prefix}.unmapped.fastq.2.gz ${prefix}.unmapped_2.fastq.gz + fi + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + bowtie2: \$(echo \$(bowtie2 --version 2>&1) | sed 's/^.*bowtie2-align-s version //; s/ .*\$//') + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + pigz: \$( pigz --version 2>&1 | sed 's/pigz //g' ) + END_VERSIONS + """ + } +} diff --git a/modules/nf-core/modules/bowtie2/align/meta.yml b/modules/nf-core/modules/bowtie2/align/meta.yml new file mode 100644 index 000000000..77c9e3970 --- /dev/null +++ b/modules/nf-core/modules/bowtie2/align/meta.yml @@ -0,0 +1,51 @@ +name: bowtie2_align +description: Align reads to a reference genome using bowtie2 +keywords: + - align + - fasta + - genome + - reference +tools: + - bowtie2: + description: | + Bowtie 2 is an ultrafast and memory-efficient tool for aligning + sequencing reads to long reference sequences. + homepage: http://bowtie-bio.sourceforge.net/bowtie2/index.shtml + documentation: http://bowtie-bio.sourceforge.net/bowtie2/manual.shtml + doi: 10.1038/nmeth.1923 + licence: ['GPL-3.0-or-later'] +input: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - reads: + type: file + description: | + List of input FastQ files of size 1 and 2 for single-end and paired-end data, + respectively. + - index: + type: file + description: Bowtie2 genome index files + pattern: "*.ebwt" +output: + - bam: + type: file + description: Output BAM file containing read alignments + pattern: "*.{bam}" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" + - fastq: + type: file + description: Unaligned FastQ files + pattern: "*.fastq.gz" + - log: + type: file + description: Aligment log + pattern: "*.log" +authors: + - "@joseespinosa" + - "@drpatelh" From 1ac2e936969d717089b3b01c94ba668b721e6074 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 18 Jan 2022 23:30:22 +0100 Subject: [PATCH 287/538] Add bowtie/build module --- modules.json | 6 ++++ modules/nf-core/modules/bowtie2/build/main.nf | 27 +++++++++++++++ .../nf-core/modules/bowtie2/build/meta.yml | 33 +++++++++++++++++++ 3 files changed, 66 insertions(+) create mode 100644 modules/nf-core/modules/bowtie2/build/main.nf create mode 100644 modules/nf-core/modules/bowtie2/build/meta.yml diff --git a/modules.json b/modules.json index 06340876b..d247eaf43 100644 --- a/modules.json +++ b/modules.json @@ -3,6 +3,12 @@ "homePage": "https://github.com/nf-core/chipseq", "repos": { "nf-core/modules": { + "bowtie2/align": { + "git_sha": "3f9a0285816a2e0ae73a3875fb5ae4b409da5952" + }, + "bowtie2/build": { + "git_sha": "e3285528aca2733ff2d544cb5e5fcc34599226f3" + }, "bwa/index": { "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, diff --git a/modules/nf-core/modules/bowtie2/build/main.nf b/modules/nf-core/modules/bowtie2/build/main.nf new file mode 100644 index 000000000..da2e9ed52 --- /dev/null +++ b/modules/nf-core/modules/bowtie2/build/main.nf @@ -0,0 +1,27 @@ +process BOWTIE2_BUILD { + tag "$fasta" + label 'process_high' + + conda (params.enable_conda ? 'bioconda::bowtie2=2.4.4' : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/bowtie2:2.4.4--py39hbb4e92a_0' : + 'quay.io/biocontainers/bowtie2:2.4.4--py39hbb4e92a_0' }" + + input: + path fasta + + output: + path 'bowtie2' , emit: index + path "versions.yml" , emit: versions + + script: + def args = task.ext.args ?: '' + """ + mkdir bowtie2 + bowtie2-build $args --threads $task.cpus $fasta bowtie2/${fasta.baseName} + cat <<-END_VERSIONS > versions.yml + "${task.process}": + bowtie2: \$(echo \$(bowtie2 --version 2>&1) | sed 's/^.*bowtie2-align-s version //; s/ .*\$//') + END_VERSIONS + """ +} diff --git a/modules/nf-core/modules/bowtie2/build/meta.yml b/modules/nf-core/modules/bowtie2/build/meta.yml new file mode 100644 index 000000000..ecc54e9b0 --- /dev/null +++ b/modules/nf-core/modules/bowtie2/build/meta.yml @@ -0,0 +1,33 @@ +name: bowtie2_build +description: Builds bowtie index for reference genome +keywords: + - build + - index + - fasta + - genome + - reference +tools: + - bowtie2: + description: | + Bowtie 2 is an ultrafast and memory-efficient tool for aligning + sequencing reads to long reference sequences. + homepage: http://bowtie-bio.sourceforge.net/bowtie2/index.shtml + documentation: http://bowtie-bio.sourceforge.net/bowtie2/manual.shtml + doi: 10.1038/nmeth.1923 + licence: ['GPL-3.0-or-later'] +input: + - fasta: + type: file + description: Input genome fasta file +output: + - index: + type: file + description: Bowtie2 genome index files + pattern: "*.bt2" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" +authors: + - "@joseespinosa" + - "@drpatelh" From 74e014899dbde7ba0ffe4b6da75fc7eb70b14d96 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 18 Jan 2022 23:30:52 +0100 Subject: [PATCH 288/538] Add bowtie2 as aligner --- conf/modules.config | 132 ++++++++++++-------------- main.nf | 16 ++-- subworkflows/local/prepare_genome.nf | 22 ++++- subworkflows/nf-core/align_bowtie2.nf | 38 ++++++++ workflows/chipseq.nf | 24 ++++- 5 files changed, 149 insertions(+), 83 deletions(-) create mode 100644 subworkflows/nf-core/align_bowtie2.nf diff --git a/conf/modules.config b/conf/modules.config index 97e6ee474..ebf071458 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -60,14 +60,6 @@ process { enabled: params.save_reference ] } - withName: BWA_INDEX { - ext.args = '-a bwtsw' - publishDir = [ - path: { "${params.outdir}/genome/index" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } withName: GFFREAD { ext.args = '--keep-exon-attrs -F -T' publishDir = [ @@ -145,9 +137,7 @@ if (!params.skip_trimming) { } process { - withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_BWA_MEM:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { - // TODO: substitute by this line when multiple aligners are implemented - // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ path: { "${params.outdir}/bwa/library" }, @@ -156,9 +146,7 @@ process { enabled: params.save_align_intermeds ] } - withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_BWA_MEM:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { - // TODO: substitute by this line when multiple aligners are implemented - // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { // ext.args = params.bam_csi_index ? '-c' : '' ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ @@ -168,9 +156,7 @@ process { enabled: params.save_align_intermeds ] } - withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_BWA_MEM:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:.*' { - // TODO: substitute by this line when multiple aligners are implemented - // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_STATS' { + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:SAMTOOLS_STATS' { // ext.args = params.bam_csi_index ? '-c' : '' ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ @@ -180,65 +166,67 @@ process { enabled: params.save_align_intermeds ] } - withName: BWA_MEM { - ext.args = [ - '-M', - params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' - ].join(' ').trim() - ext.args2 = '-h -F 0x0100 -O BAM' - ext.prefix = { "${meta.id}.Lb" } - publishDir = [ - path: { "${params.outdir}/bwa/library" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } } -process { - withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_CHROMAP:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { - // TODO: substitute by this line when multiple aligners are implemented - // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { - ext.prefix = { "${meta.id}.Lb.sorted" } - publishDir = [ - path: { "${params.outdir}/chromap/library" }, - mode: 'copy', - pattern: "*.bam", - enabled: params.save_align_intermeds - ] - } - withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_CHROMAP:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { - // TODO: substitute by this line when multiple aligners are implemented - // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { - // ext.args = params.bam_csi_index ? '-c' : '' - ext.prefix = { "${meta.id}.Lb.sorted" } - publishDir = [ - path: { "${params.outdir}/chromap/library" }, - mode: 'copy', - pattern: '*.{bai,csi}', - enabled: params.save_align_intermeds - ] +if (params.aligner == 'bwa') { + process { + withName: BWA_INDEX { + ext.args = '-a bwtsw' + publishDir = [ + path: { "${params.outdir}/genome/${params.aligner}/index" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: BWA_MEM { + ext.args = [ + '-M', + params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' + ].join(' ').trim() + ext.args2 = '-h -F 0x0100 -O BAM' + ext.prefix = { "${meta.id}.Lb" } + publishDir = [ + path: { "${params.outdir}/${params.aligner}/library" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } } - withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_CHROMAP:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:.*' { - // TODO: substitute by this line when multiple aligners are implemented - // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_STATS' { - // ext.args = params.bam_csi_index ? '-c' : '' - ext.prefix = { "${meta.id}.Lb.sorted" } - publishDir = [ - path: { "${params.outdir}/chromap/library" }, - mode: 'copy', - pattern: "*.{stats,flagstat,idxstats}", - enabled: params.save_align_intermeds - ] +} + +if (params.aligner == 'bowtie2') { + process { + withName: BOWTIE2_BUILD { + ext.args = '' + publishDir = [ + path: { "${params.outdir}/genome/${params.aligner}/index" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: BOWTIE2_ALIGN { + ext.args = '' + ext.prefix = { "${meta.id}.Lb" } + publishDir = [ + path: { "${params.outdir}/${params.aligner}/library" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } } - withName: CHROMAP_CHROMAP { - ext.args = '--preset chip' - ext.prefix = { "${meta.id}.Lb" } - publishDir = [ - path: { "${params.outdir}/chromap/library" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] +} + +if (params.aligner == 'chromap') { + process { + withName: CHROMAP_CHROMAP { + ext.args = '--preset chip' + ext.prefix = { "${meta.id}.Lb" } + publishDir = [ + path: { "${params.outdir}/${params.aligner}/library" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } } } diff --git a/main.nf b/main.nf index f2fe7440c..2ef142eea 100755 --- a/main.nf +++ b/main.nf @@ -17,13 +17,15 @@ nextflow.enable.dsl = 2 ======================================================================================== */ -params.fasta = WorkflowMain.getGenomeAttribute(params, 'fasta') -params.bwa_index = WorkflowMain.getGenomeAttribute(params, 'bwa') -params.gtf = WorkflowMain.getGenomeAttribute(params, 'gtf') -params.gff = WorkflowMain.getGenomeAttribute(params, 'gff') -params.gene_bed = WorkflowMain.getGenomeAttribute(params, 'gene_bed') -params.macs_gsize = WorkflowMain.getGenomeAttribute(params, 'macs_gsize') -params.blacklist = WorkflowMain.getGenomeAttribute(params, 'blacklist') +params.fasta = WorkflowMain.getGenomeAttribute(params, 'fasta') +params.bwa_index = WorkflowMain.getGenomeAttribute(params, 'bwa') +params.bowtie2_index = WorkflowMain.getGenomeAttribute(params, 'bowtie2') +params.chromap_index = WorkflowMain.getGenomeAttribute(params, 'chromap') +params.gtf = WorkflowMain.getGenomeAttribute(params, 'gtf') +params.gff = WorkflowMain.getGenomeAttribute(params, 'gff') +params.gene_bed = WorkflowMain.getGenomeAttribute(params, 'gene_bed') +params.macs_gsize = WorkflowMain.getGenomeAttribute(params, 'macs_gsize') +params.blacklist = WorkflowMain.getGenomeAttribute(params, 'blacklist') /* ======================================================================================== diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index fe89b57c0..84ee83f22 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -12,6 +12,7 @@ include { UNTAR } from '../../modules/nf-core/modules/untar/main' include { GFFREAD } from '../../modules/nf-core/modules/gffread/main' include { CUSTOM_GETCHROMSIZES } from '../../modules/nf-core/modules/custom/getchromsizes/main' include { BWA_INDEX } from '../../modules/nf-core/modules/bwa/index/main' +include { BOWTIE2_BUILD } from '../../modules/nf-core/modules/bowtie2/build/main' include { CHROMAP_INDEX } from '../../modules/nf-core/modules/chromap/index/main' include { GTF2BED } from '../../modules/local/gtf2bed' @@ -129,6 +130,24 @@ workflow PREPARE_GENOME { } } + // + // Uncompress Bowtie2 index or generate from scratch if required + // + ch_bowtie2_index = Channel.empty() + if (prepare_tool_index == 'bowtie2') { + if (params.bowtie2_index) { + if (params.bowtie2_index.endsWith('.tar.gz')) { + ch_bowtie2_index = UNTAR ( params.bowtie2_index ).untar + ch_versions = ch_versions.mix(UNTAR.out.versions) + } else { + ch_bowtie2_index = file(params.bowtie2_index) + } + } else { + ch_bowtie2_index = BOWTIE2_BUILD ( ch_fasta ).index + ch_versions = ch_versions.mix(BOWTIE2_BUILD.out.versions) + } + } + // // Uncompress CHROMAP index or generate from scratch if required // @@ -136,7 +155,7 @@ workflow PREPARE_GENOME { if (prepare_tool_index == 'chromap') { if (params.chromap_index) { if (params.chromap_index.endsWith('.tar.gz')) { - ch_bwa_index = UNTAR ( params.chromap_index ).untar + ch_chromap_index = UNTAR ( params.chromap_index ).untar ch_versions = ch_versions.mix(UNTAR.out.versions) } else { ch_chromap_index = file(params.chromap_index) @@ -154,6 +173,7 @@ workflow PREPARE_GENOME { chrom_sizes = ch_chrom_sizes // path: genome.sizes blacklist = ch_blacklist // path: blacklist.bed bwa_index = ch_bwa_index // path: bwa/index/ + bowtie2_index = ch_bowtie2_index // path: bowtie2/index/ chromap_index = ch_chromap_index // path: genome.index versions = ch_versions.ifEmpty(null) // channel: [ versions.yml ] diff --git a/subworkflows/nf-core/align_bowtie2.nf b/subworkflows/nf-core/align_bowtie2.nf new file mode 100644 index 000000000..bb0888f3c --- /dev/null +++ b/subworkflows/nf-core/align_bowtie2.nf @@ -0,0 +1,38 @@ +/* + * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats + */ + +include { BOWTIE2_ALIGN } from '../../modules/nf-core/modules/bowtie2/align/main' +include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' + +workflow ALIGN_BOWTIE2 { + take: + reads // channel: [ val(meta), [ reads ] ] + index // path: /path/to/index + save_unaligned // boolean: true/false + + main: + + ch_versions = Channel.empty() + + // + // Map reads with BWA + // + BOWTIE2_ALIGN(reads, index, save_unaligned) + ch_versions = ch_versions.mix(BOWTIE2_ALIGN.out.versions.first()) + + // + // Sort, index BAM file and run samtools stats, flagstat and idxstats + // + BAM_SORT_SAMTOOLS(BOWTIE2_ALIGN.out.bam) + ch_versions = ch_versions.mix(BAM_SORT_SAMTOOLS.out.versions.first()) + + emit: + bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] + bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + + versions = ch_versions // path: versions.yml +} diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index a483b562c..b6375d6b5 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -5,21 +5,21 @@ */ def valid_params = [ - aligners : [ 'bwa', 'chromap' ] + aligners : [ 'bwa', 'bowtie2', 'chromap' ] ] def summary_params = NfcoreSchema.paramsSummaryMap(workflow, params) // Validate input parameters WorkflowChipseq.initialise(params, log) -// WorkflowChipseq.initialise(params, log, valid_params) +// WorkflowChipseq.initialise(params, log, valid_params) //TODO include valid_params // Check input path parameters to see if they exist def checkPathParamList = [ params.input, params.multiqc_config, params.fasta, params.gtf, params.gff, params.gene_bed, - params.bwa_index, + params.bwa_index, //TODO change now more aligners params.blacklist, params.bamtools_filter_pe_config, params.bamtools_filter_se_config ] @@ -119,6 +119,7 @@ include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../module include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' include { ALIGN_BWA_MEM } from '../subworkflows/nf-core/align_bwa_mem' include { ALIGN_CHROMAP } from '../subworkflows/nf-core/align_chromap' +include { ALIGN_BOWTIE2 } from '../subworkflows/nf-core/align_bowtie2' include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' /* @@ -183,6 +184,20 @@ workflow CHIPSEQ { ch_samtools_idxstats = ALIGN_BWA_MEM.out.idxstats ch_versions = ch_versions.mix(ALIGN_BWA_MEM.out.versions.first()) } + params.save_unaligned = false + if (params.aligner == 'bowtie2') { + ALIGN_BOWTIE2 ( + FASTQC_TRIMGALORE.out.reads, + PREPARE_GENOME.out.bowtie2_index, + params.save_unaligned + ) + ch_genome_bam = ALIGN_BOWTIE2.out.bam + ch_genome_bam_index = ALIGN_BOWTIE2.out.bai + ch_samtools_stats = ALIGN_BOWTIE2.out.stats + ch_samtools_flagstat = ALIGN_BOWTIE2.out.flagstat + ch_samtools_idxstats = ALIGN_BOWTIE2.out.idxstats + ch_versions = ch_versions.mix(ALIGN_BOWTIE2.out.versions.first()) + } if (params.aligner == 'chromap') { ALIGN_CHROMAP ( @@ -192,6 +207,9 @@ workflow CHIPSEQ { ) ch_genome_bam = ALIGN_CHROMAP.out.bam ch_genome_bam_index = ALIGN_CHROMAP.out.bai + // ch_samtools_stats = ALIGN_CHROMAP.out.stats //TODO + // ch_samtools_flagstat = ALIGN_CHROMAP.out.flagstat + // ch_samtools_idxstats = ALIGN_CHROMAP.out.idxstats ch_versions = ch_versions.mix(ALIGN_CHROMAP.out.versions.first()) } From 52f127fbf545e4678d1bdad47d5d663c802e7850 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 19 Jan 2022 11:33:48 +0100 Subject: [PATCH 289/538] Adding star/genomegenerate module --- modules.json | 3 + .../modules/star/genomegenerate/main.nf | 66 +++++++++++++++++++ .../modules/star/genomegenerate/meta.yml | 37 +++++++++++ 3 files changed, 106 insertions(+) create mode 100644 modules/nf-core/modules/star/genomegenerate/main.nf create mode 100644 modules/nf-core/modules/star/genomegenerate/meta.yml diff --git a/modules.json b/modules.json index d247eaf43..9286e6370 100644 --- a/modules.json +++ b/modules.json @@ -87,6 +87,9 @@ "samtools/stats": { "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, + "star/genomegenerate": { + "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + }, "subread/featurecounts": { "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, diff --git a/modules/nf-core/modules/star/genomegenerate/main.nf b/modules/nf-core/modules/star/genomegenerate/main.nf new file mode 100644 index 000000000..ad32c0dd8 --- /dev/null +++ b/modules/nf-core/modules/star/genomegenerate/main.nf @@ -0,0 +1,66 @@ +process STAR_GENOMEGENERATE { + tag "$fasta" + label 'process_high' + + // Note: 2.7X indices incompatible with AWS iGenomes. + conda (params.enable_conda ? "bioconda::star=2.7.9a bioconda::samtools=1.13 conda-forge::gawk=5.1.0" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/mulled-v2-1fa26d1ce03c295fe2fdcf85831a92fbcbd7e8c2:a7908dfb0485a80ca94e4d17b0ac991532e4e989-0' : + 'quay.io/biocontainers/mulled-v2-1fa26d1ce03c295fe2fdcf85831a92fbcbd7e8c2:a7908dfb0485a80ca94e4d17b0ac991532e4e989-0' }" + + input: + path fasta + path gtf + + output: + path "star" , emit: index + path "versions.yml" , emit: versions + + script: + def args = task.ext.args ?: '' + def args_list = args.tokenize() + def memory = task.memory ? "--limitGenomeGenerateRAM ${task.memory.toBytes() - 100000000}" : '' + if (args_list.contains('--genomeSAindexNbases')) { + """ + mkdir star + STAR \\ + --runMode genomeGenerate \\ + --genomeDir star/ \\ + --genomeFastaFiles $fasta \\ + --sjdbGTFfile $gtf \\ + --runThreadN $task.cpus \\ + $memory \\ + $args + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + star: \$(STAR --version | sed -e "s/STAR_//g") + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + gawk: \$(echo \$(gawk --version 2>&1) | sed 's/^.*GNU Awk //; s/, .*\$//') + END_VERSIONS + """ + } else { + """ + samtools faidx $fasta + NUM_BASES=`gawk '{sum = sum + \$2}END{if ((log(sum)/log(2))/2 - 1 > 14) {printf "%.0f", 14} else {printf "%.0f", (log(sum)/log(2))/2 - 1}}' ${fasta}.fai` + + mkdir star + STAR \\ + --runMode genomeGenerate \\ + --genomeDir star/ \\ + --genomeFastaFiles $fasta \\ + --sjdbGTFfile $gtf \\ + --runThreadN $task.cpus \\ + --genomeSAindexNbases \$NUM_BASES \\ + $memory \\ + $args + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + star: \$(STAR --version | sed -e "s/STAR_//g") + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + gawk: \$(echo \$(gawk --version 2>&1) | sed 's/^.*GNU Awk //; s/, .*\$//') + END_VERSIONS + """ + } +} diff --git a/modules/nf-core/modules/star/genomegenerate/meta.yml b/modules/nf-core/modules/star/genomegenerate/meta.yml new file mode 100644 index 000000000..04ade1957 --- /dev/null +++ b/modules/nf-core/modules/star/genomegenerate/meta.yml @@ -0,0 +1,37 @@ +name: star_genomegenerate +description: Create index for STAR +keywords: + - index + - fasta + - genome + - reference +tools: + - star: + description: | + STAR is a software package for mapping DNA sequences against + a large reference genome, such as the human genome. + homepage: https://github.com/alexdobin/STAR + manual: https://github.com/alexdobin/STAR/blob/master/doc/STARmanual.pdf + doi: 10.1093/bioinformatics/bts635 + licence: ['MIT'] +input: + - fasta: + type: file + description: Fasta file of the reference genome + - gtf: + type: file + description: GTF file of the reference genome + +output: + - index: + type: directory + description: Folder containing the star index files + pattern: "star" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" + +authors: + - "@kevinmenden" + - "@drpatelh" From 71cfadba5dec780501cbe3468a32fe98161a8e37 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 19 Jan 2022 11:35:11 +0100 Subject: [PATCH 290/538] Adding star/align module --- modules.json | 3 + modules/nf-core/modules/star/align/main.nf | 68 +++++++++++++++++ modules/nf-core/modules/star/align/meta.yml | 81 +++++++++++++++++++++ 3 files changed, 152 insertions(+) create mode 100644 modules/nf-core/modules/star/align/main.nf create mode 100644 modules/nf-core/modules/star/align/meta.yml diff --git a/modules.json b/modules.json index 9286e6370..9da79a53c 100644 --- a/modules.json +++ b/modules.json @@ -87,6 +87,9 @@ "samtools/stats": { "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, + "star/align": { + "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + }, "star/genomegenerate": { "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, diff --git a/modules/nf-core/modules/star/align/main.nf b/modules/nf-core/modules/star/align/main.nf new file mode 100644 index 000000000..9725496fd --- /dev/null +++ b/modules/nf-core/modules/star/align/main.nf @@ -0,0 +1,68 @@ +process STAR_ALIGN { + tag "$meta.id" + label 'process_high' + + // Note: 2.7X indices incompatible with AWS iGenomes. + conda (params.enable_conda ? 'bioconda::star=2.7.9a' : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/star:2.7.9a--h9ee0642_0' : + 'quay.io/biocontainers/star:2.7.9a--h9ee0642_0' }" + + input: + tuple val(meta), path(reads) + path index + path gtf + val star_ignore_sjdbgtf + val seq_platform + val seq_center + + output: + tuple val(meta), path('*d.out.bam') , emit: bam + tuple val(meta), path('*Log.final.out') , emit: log_final + tuple val(meta), path('*Log.out') , emit: log_out + tuple val(meta), path('*Log.progress.out'), emit: log_progress + path "versions.yml" , emit: versions + + tuple val(meta), path('*sortedByCoord.out.bam') , optional:true, emit: bam_sorted + tuple val(meta), path('*toTranscriptome.out.bam'), optional:true, emit: bam_transcript + tuple val(meta), path('*Aligned.unsort.out.bam') , optional:true, emit: bam_unsorted + tuple val(meta), path('*fastq.gz') , optional:true, emit: fastq + tuple val(meta), path('*.tab') , optional:true, emit: tab + tuple val(meta), path('*.out.junction') , optional:true, emit: junction + + script: + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" + def ignore_gtf = star_ignore_sjdbgtf ? '' : "--sjdbGTFfile $gtf" + def seq_platform = seq_platform ? "'PL:$seq_platform'" : "" + def seq_center = seq_center ? "--outSAMattrRGline ID:$prefix 'CN:$seq_center' 'SM:$prefix' $seq_platform " : "--outSAMattrRGline ID:$prefix 'SM:$prefix' $seq_platform " + def out_sam_type = (args.contains('--outSAMtype')) ? '' : '--outSAMtype BAM Unsorted' + def mv_unsorted_bam = (args.contains('--outSAMtype BAM Unsorted SortedByCoordinate')) ? "mv ${prefix}.Aligned.out.bam ${prefix}.Aligned.unsort.out.bam" : '' + """ + STAR \\ + --genomeDir $index \\ + --readFilesIn $reads \\ + --runThreadN $task.cpus \\ + --outFileNamePrefix $prefix. \\ + $out_sam_type \\ + $ignore_gtf \\ + $seq_center \\ + $args + + $mv_unsorted_bam + + if [ -f ${prefix}.Unmapped.out.mate1 ]; then + mv ${prefix}.Unmapped.out.mate1 ${prefix}.unmapped_1.fastq + gzip ${prefix}.unmapped_1.fastq + fi + if [ -f ${prefix}.Unmapped.out.mate2 ]; then + mv ${prefix}.Unmapped.out.mate2 ${prefix}.unmapped_2.fastq + gzip ${prefix}.unmapped_2.fastq + fi + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + star: \$(STAR --version | sed -e "s/STAR_//g") + END_VERSIONS + """ +} diff --git a/modules/nf-core/modules/star/align/meta.yml b/modules/nf-core/modules/star/align/meta.yml new file mode 100644 index 000000000..2d78b81ae --- /dev/null +++ b/modules/nf-core/modules/star/align/meta.yml @@ -0,0 +1,81 @@ +name: star_align +description: Align reads to a reference genome using STAR +keywords: + - align + - fasta + - genome + - reference +tools: + - star: + description: | + STAR is a software package for mapping DNA sequences against + a large reference genome, such as the human genome. + homepage: https://github.com/alexdobin/STAR + manual: https://github.com/alexdobin/STAR/blob/master/doc/STARmanual.pdf + doi: 10.1093/bioinformatics/bts635 + licence: ['MIT'] +input: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - reads: + type: file + description: | + List of input FastQ files of size 1 and 2 for single-end and paired-end data, + respectively. + - index: + type: directory + description: STAR genome index + pattern: "star" +output: + - bam: + type: file + description: Output BAM file containing read alignments + pattern: "*.{bam}" + - log_final: + type: file + description: STAR final log file + pattern: "*Log.final.out" + - log_out: + type: file + description: STAR lot out file + pattern: "*Log.out" + - log_progress: + type: file + description: STAR log progress file + pattern: "*Log.progress.out" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" + - bam_sorted: + type: file + description: Sorted BAM file of read alignments (optional) + pattern: "*sortedByCoord.out.bam" + - bam_transcript: + type: file + description: Output BAM file of transcriptome alignment (optional) + pattern: "*toTranscriptome.out.bam" + - bam_unsorted: + type: file + description: Unsorted BAM file of read alignments (optional) + pattern: "*Aligned.unsort.out.bam" + - fastq: + type: file + description: Unmapped FastQ files (optional) + pattern: "*fastq.gz" + - tab: + type: file + description: STAR output tab file(s) (optional) + pattern: "*.tab" + - junction: + type: file + description: STAR chimeric junction output file (optional) + pattern: "*.out.junction" + +authors: + - "@kevinmenden" + - "@drpatelh" + - "@praveenraj2018" From 5e280431bb75fbe4c5fcd00ce74c4a3a1394b492 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 19 Jan 2022 14:38:51 +0100 Subject: [PATCH 291/538] Create star modules locally since the version in modules does not work with igenomes --- modules.json | 6 -- .../align/main.nf => local/star_align.nf} | 19 ++--- .../main.nf => local/star_genomegenerate.nf} | 0 modules/nf-core/modules/star/align/meta.yml | 81 ------------------- .../modules/star/genomegenerate/meta.yml | 37 --------- 5 files changed, 7 insertions(+), 136 deletions(-) rename modules/{nf-core/modules/star/align/main.nf => local/star_align.nf} (70%) rename modules/{nf-core/modules/star/genomegenerate/main.nf => local/star_genomegenerate.nf} (100%) delete mode 100644 modules/nf-core/modules/star/align/meta.yml delete mode 100644 modules/nf-core/modules/star/genomegenerate/meta.yml diff --git a/modules.json b/modules.json index 9da79a53c..d247eaf43 100644 --- a/modules.json +++ b/modules.json @@ -87,12 +87,6 @@ "samtools/stats": { "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, - "star/align": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" - }, - "star/genomegenerate": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" - }, "subread/featurecounts": { "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, diff --git a/modules/nf-core/modules/star/align/main.nf b/modules/local/star_align.nf similarity index 70% rename from modules/nf-core/modules/star/align/main.nf rename to modules/local/star_align.nf index 9725496fd..5a67b1716 100644 --- a/modules/nf-core/modules/star/align/main.nf +++ b/modules/local/star_align.nf @@ -3,40 +3,35 @@ process STAR_ALIGN { label 'process_high' // Note: 2.7X indices incompatible with AWS iGenomes. - conda (params.enable_conda ? 'bioconda::star=2.7.9a' : null) + conda (params.enable_conda ? "bioconda::star=2.6.1d" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/star:2.7.9a--h9ee0642_0' : - 'quay.io/biocontainers/star:2.7.9a--h9ee0642_0' }" + 'https://depot.galaxyproject.org/singularity/star:2.6.1d--0' : + 'quay.io/biocontainers/star:2.6.1d--0' }" input: tuple val(meta), path(reads) path index path gtf - val star_ignore_sjdbgtf - val seq_platform - val seq_center output: tuple val(meta), path('*d.out.bam') , emit: bam tuple val(meta), path('*Log.final.out') , emit: log_final tuple val(meta), path('*Log.out') , emit: log_out tuple val(meta), path('*Log.progress.out'), emit: log_progress - path "versions.yml" , emit: versions + path "versions.yml" , emit: versions tuple val(meta), path('*sortedByCoord.out.bam') , optional:true, emit: bam_sorted tuple val(meta), path('*toTranscriptome.out.bam'), optional:true, emit: bam_transcript tuple val(meta), path('*Aligned.unsort.out.bam') , optional:true, emit: bam_unsorted tuple val(meta), path('*fastq.gz') , optional:true, emit: fastq tuple val(meta), path('*.tab') , optional:true, emit: tab - tuple val(meta), path('*.out.junction') , optional:true, emit: junction script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" - def ignore_gtf = star_ignore_sjdbgtf ? '' : "--sjdbGTFfile $gtf" - def seq_platform = seq_platform ? "'PL:$seq_platform'" : "" - def seq_center = seq_center ? "--outSAMattrRGline ID:$prefix 'CN:$seq_center' 'SM:$prefix' $seq_platform " : "--outSAMattrRGline ID:$prefix 'SM:$prefix' $seq_platform " - def out_sam_type = (args.contains('--outSAMtype')) ? '' : '--outSAMtype BAM Unsorted' + def ignore_gtf = params.star_ignore_sjdbgtf ? '' : "--sjdbGTFfile $gtf" + def seq_center = params.seq_center ? "--outSAMattrRGline ID:$prefix 'CN:$params.seq_center' 'SM:$prefix'" : "--outSAMattrRGline ID:$prefix 'SM:$prefix'" + def out_sam_type = (args.contains('--outSAMtype')) ? '' : '--outSAMtype BAM Unsorted' def mv_unsorted_bam = (args.contains('--outSAMtype BAM Unsorted SortedByCoordinate')) ? "mv ${prefix}.Aligned.out.bam ${prefix}.Aligned.unsort.out.bam" : '' """ STAR \\ diff --git a/modules/nf-core/modules/star/genomegenerate/main.nf b/modules/local/star_genomegenerate.nf similarity index 100% rename from modules/nf-core/modules/star/genomegenerate/main.nf rename to modules/local/star_genomegenerate.nf diff --git a/modules/nf-core/modules/star/align/meta.yml b/modules/nf-core/modules/star/align/meta.yml deleted file mode 100644 index 2d78b81ae..000000000 --- a/modules/nf-core/modules/star/align/meta.yml +++ /dev/null @@ -1,81 +0,0 @@ -name: star_align -description: Align reads to a reference genome using STAR -keywords: - - align - - fasta - - genome - - reference -tools: - - star: - description: | - STAR is a software package for mapping DNA sequences against - a large reference genome, such as the human genome. - homepage: https://github.com/alexdobin/STAR - manual: https://github.com/alexdobin/STAR/blob/master/doc/STARmanual.pdf - doi: 10.1093/bioinformatics/bts635 - licence: ['MIT'] -input: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - reads: - type: file - description: | - List of input FastQ files of size 1 and 2 for single-end and paired-end data, - respectively. - - index: - type: directory - description: STAR genome index - pattern: "star" -output: - - bam: - type: file - description: Output BAM file containing read alignments - pattern: "*.{bam}" - - log_final: - type: file - description: STAR final log file - pattern: "*Log.final.out" - - log_out: - type: file - description: STAR lot out file - pattern: "*Log.out" - - log_progress: - type: file - description: STAR log progress file - pattern: "*Log.progress.out" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" - - bam_sorted: - type: file - description: Sorted BAM file of read alignments (optional) - pattern: "*sortedByCoord.out.bam" - - bam_transcript: - type: file - description: Output BAM file of transcriptome alignment (optional) - pattern: "*toTranscriptome.out.bam" - - bam_unsorted: - type: file - description: Unsorted BAM file of read alignments (optional) - pattern: "*Aligned.unsort.out.bam" - - fastq: - type: file - description: Unmapped FastQ files (optional) - pattern: "*fastq.gz" - - tab: - type: file - description: STAR output tab file(s) (optional) - pattern: "*.tab" - - junction: - type: file - description: STAR chimeric junction output file (optional) - pattern: "*.out.junction" - -authors: - - "@kevinmenden" - - "@drpatelh" - - "@praveenraj2018" diff --git a/modules/nf-core/modules/star/genomegenerate/meta.yml b/modules/nf-core/modules/star/genomegenerate/meta.yml deleted file mode 100644 index 04ade1957..000000000 --- a/modules/nf-core/modules/star/genomegenerate/meta.yml +++ /dev/null @@ -1,37 +0,0 @@ -name: star_genomegenerate -description: Create index for STAR -keywords: - - index - - fasta - - genome - - reference -tools: - - star: - description: | - STAR is a software package for mapping DNA sequences against - a large reference genome, such as the human genome. - homepage: https://github.com/alexdobin/STAR - manual: https://github.com/alexdobin/STAR/blob/master/doc/STARmanual.pdf - doi: 10.1093/bioinformatics/bts635 - licence: ['MIT'] -input: - - fasta: - type: file - description: Fasta file of the reference genome - - gtf: - type: file - description: GTF file of the reference genome - -output: - - index: - type: directory - description: Folder containing the star index files - pattern: "star" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" - -authors: - - "@kevinmenden" - - "@drpatelh" From 529783ba86b04334c590c6cd0b6d9f2ca50b67ad Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 19 Jan 2022 14:51:58 +0100 Subject: [PATCH 292/538] Add star as aligner --- subworkflows/local/prepare_genome.nf | 20 ++++++++++++ subworkflows/nf-core/align_star.nf | 48 ++++++++++++++++++++++++++++ workflows/chipseq.nf | 22 ++++++++++++- 3 files changed, 89 insertions(+), 1 deletion(-) create mode 100644 subworkflows/nf-core/align_star.nf diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index 84ee83f22..5d27d756b 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -17,6 +17,7 @@ include { CHROMAP_INDEX } from '../../modules/nf-core/modules/chromap/ind include { GTF2BED } from '../../modules/local/gtf2bed' include { GENOME_BLACKLIST_REGIONS } from '../../modules/local/genome_blacklist_regions' +include { STAR_GENOMEGENERATE } from '../../modules/local/star_genomegenerate' workflow PREPARE_GENOME { take: @@ -166,6 +167,24 @@ workflow PREPARE_GENOME { } } + // + // Uncompress STAR index or generate from scratch if required + // + ch_star_index = Channel.empty() + if (prepare_tool_index == 'star') { + if (params.star_index) { + if (params.star_index.endsWith('.tar.gz')) { + ch_star_index = UNTAR_STAR_INDEX ( params.star_index ).untar + ch_versions = ch_versions.mix(UNTAR_STAR_INDEX.out.versions) + } else { + ch_star_index = file(params.star_index) + } + } else { + ch_star_index = STAR_GENOMEGENERATE ( ch_fasta, ch_gtf ).index + ch_versions = ch_versions.mix(STAR_GENOMEGENERATE.out.versions) + } + } + emit: fasta = ch_fasta // path: genome.fasta gtf = ch_gtf // path: genome.gtf @@ -175,6 +194,7 @@ workflow PREPARE_GENOME { bwa_index = ch_bwa_index // path: bwa/index/ bowtie2_index = ch_bowtie2_index // path: bowtie2/index/ chromap_index = ch_chromap_index // path: genome.index + star_index = ch_chromap_index // path: star/index/ versions = ch_versions.ifEmpty(null) // channel: [ versions.yml ] } diff --git a/subworkflows/nf-core/align_star.nf b/subworkflows/nf-core/align_star.nf new file mode 100644 index 000000000..248efe40f --- /dev/null +++ b/subworkflows/nf-core/align_star.nf @@ -0,0 +1,48 @@ +/* + * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats + */ + +include { STAR_ALIGN } from '../../modules/local/star_align' +include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' + +workflow ALIGN_STAR { + take: + reads // channel: [ val(meta), [ reads ] ] + index // channel: /path/to/star/index/ + gtf // channel: /path/to/genome.gtf + + main: + + ch_versions = Channel.empty() + + // + // Map reads with STAR + // + STAR_ALIGN ( reads, index, gtf ) + ch_versions = ch_versions.mix(STAR_ALIGN.out.versions.first()) + + // + // Sort, index BAM file and run samtools stats, flagstat and idxstats + // + BAM_SORT_SAMTOOLS ( STAR_ALIGN.out.bam ) + ch_versions = ch_versions.mix(BAM_SORT_SAMTOOLS.out.versions) + + emit: + orig_bam = STAR_ALIGN.out.bam // channel: [ val(meta), bam ] + log_final = STAR_ALIGN.out.log_final // channel: [ val(meta), log_final ] + log_out = STAR_ALIGN.out.log_out // channel: [ val(meta), log_out ] + log_progress = STAR_ALIGN.out.log_progress // channel: [ val(meta), log_progress ] + bam_sorted = STAR_ALIGN.out.bam_sorted // channel: [ val(meta), bam_sorted ] + bam_transcript = STAR_ALIGN.out.bam_transcript // channel: [ val(meta), bam_transcript ] + fastq = STAR_ALIGN.out.fastq // channel: [ val(meta), fastq ] + tab = STAR_ALIGN.out.tab // channel: [ val(meta), tab ] + + bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] + bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] + // csi = BAM_SORT_SAMTOOLS.out.csi // channel: [ val(meta), [ csi ] ] //TODO + stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + + versions = ch_versions // channel: [ versions.yml ] +} diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index b6375d6b5..c8cf7bcc7 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -5,7 +5,7 @@ */ def valid_params = [ - aligners : [ 'bwa', 'bowtie2', 'chromap' ] + aligners : [ 'bwa', 'bowtie2', 'chromap', 'star' ] ] def summary_params = NfcoreSchema.paramsSummaryMap(workflow, params) @@ -120,6 +120,7 @@ include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalo include { ALIGN_BWA_MEM } from '../subworkflows/nf-core/align_bwa_mem' include { ALIGN_CHROMAP } from '../subworkflows/nf-core/align_chromap' include { ALIGN_BOWTIE2 } from '../subworkflows/nf-core/align_bowtie2' +include { ALIGN_STAR } from '../subworkflows/nf-core/align_star' include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' /* @@ -213,6 +214,25 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(ALIGN_CHROMAP.out.versions.first()) } + if (params.aligner == 'star') { + ALIGN_STAR ( + FASTQC_TRIMGALORE.out.reads, + PREPARE_GENOME.out.star_index, + params.save_unaligned + ) + ch_genome_bam = ALIGN_STAR.out.bam + ch_genome_bam_index = ALIGN_STAR.out.bai + ch_transcriptome_bam = ALIGN_STAR.out.bam_transcript + ch_samtools_stats = ALIGN_STAR.out.stats + ch_samtools_flagstat = ALIGN_STAR.out.flagstat + ch_samtools_idxstats = ALIGN_STAR.out.idxstats + ch_star_multiqc = ALIGN_STAR.out.log_final // TODO for the rest of aligners + // if (params.bam_csi_index) { //TODO for the rest of aligners + // ch_genome_bam_index = ALIGN_STAR.out.csi + // } + ch_versions = ch_versions.mix(ALIGN_STAR.out.versions) + } + // // SUBWORKFLOW: Merge resequenced BAM files // From 099d982356053770add66ca192c008ed1a2a7536 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 20 Jan 2022 10:17:20 +0100 Subject: [PATCH 293/538] Update nextflow schema with the new indexes --- nextflow_schema.json | 18 ++++++++++++++++++ 1 file changed, 18 insertions(+) diff --git a/nextflow_schema.json b/nextflow_schema.json index dff464078..615de8bbc 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -99,6 +99,24 @@ "description": "Full path to directory containing BWA index including base name. i.e. `/path/to/index/genome.fa`.", "fa_icon": "fas fa-bezier-curve" }, + "bowtie2_index": { + "type": "string", + "format": "path", + "fa_icon": "fas fa-bezier-curve", + "description": "Path to directory or tar.gz archive for pre-built HISAT2 index." + }, + "chromap_index": { + "type": "string", + "format": "path", + "fa_icon": "fas fa-bezier-curve", + "description": "Path to directory or tar.gz archive for pre-built Chromap index." + }, + "star_index": { + "type": "string", + "format": "path", + "fa_icon": "fas fa-bezier-curve", + "description": "Path to directory or tar.gz archive for pre-built STAR index." + }, "gene_bed": { "type": "string", "format": "file-path", From 618cef461f52a7a86ed2bf6d79e518ba086cd038 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 20 Jan 2022 10:41:09 +0100 Subject: [PATCH 294/538] Update nextflow_schema with the new index params --- nextflow_schema.json | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index 615de8bbc..fb677cd35 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -96,14 +96,14 @@ }, "bwa_index": { "type": "string", - "description": "Full path to directory containing BWA index including base name. i.e. `/path/to/index/genome.fa`.", + "description": "Path to directory or tar.gz archive for pre-built BWA index.", "fa_icon": "fas fa-bezier-curve" }, "bowtie2_index": { "type": "string", "format": "path", "fa_icon": "fas fa-bezier-curve", - "description": "Path to directory or tar.gz archive for pre-built HISAT2 index." + "description": "Path to directory or tar.gz archive for pre-built Bowtie2 index." }, "chromap_index": { "type": "string", From 573902523413dd8ae2d5bfca1644a3219087e3fc Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 20 Jan 2022 10:41:46 +0100 Subject: [PATCH 295/538] Add star to modules config --- conf/modules.config | 50 +++++++++++++++++++++++++++++++++++++++++++++ 1 file changed, 50 insertions(+) diff --git a/conf/modules.config b/conf/modules.config index ebf071458..c332fe249 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -218,6 +218,14 @@ if (params.aligner == 'bowtie2') { if (params.aligner == 'chromap') { process { + withName: CHROMAP_INDEX { + ext.args = '' + publishDir = [ + path: { "${params.outdir}/genome/${params.aligner}/index" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } withName: CHROMAP_CHROMAP { ext.args = '--preset chip' ext.prefix = { "${meta.id}.Lb" } @@ -230,6 +238,48 @@ if (params.aligner == 'chromap') { } } +if (params.aligner == 'star') { + process { + withName: STAR_GENOMEGENERATE { + ext.args = '' + publishDir = [ + path: { "${params.outdir}/genome/${params.aligner}/index" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: '.*:ALIGN_STAR:STAR_ALIGN' { + ext.args = [ + '--outSAMtype BAM Unsorted', + '--readFilesCommand zcat', + '--runRNGseed 0', + // '--outFilterMultimapNmax 20', //DEL + '--outSAMattributes NH HI AS NM MD' + // params.save_unaligned ? '--outReadsUnmapped Fastx' : '' //TODO + ].join(' ').trim() + publishDir = [ + [ + path: { "${params.outdir}/${params.aligner}/log" }, + mode: 'copy', + pattern: '*.{out,tab}' + ], + [ + path: { "${params.outdir}/${params.aligner}" }, + mode: 'copy', + pattern: '*.bam', + // enabled: params.save_align_intermeds //TODO + ], + [ + path: { "${params.outdir}/${params.aligner}/unmapped" }, + mode: 'copy', + pattern: '*.fastq.gz', + // enabled: params.save_unaligned //TODO + ] + ] + } + } +} + process { withName: PICARD_MERGESAMFILES { ext.args = 'SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' From ff4dd74c523860f4253ec4f7fdd6b82cc924e877 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 20 Jan 2022 10:45:16 +0100 Subject: [PATCH 296/538] Add check for params.aligner in initialize function --- lib/WorkflowChipseq.groovy | 9 ++++++++- main.nf | 1 + workflows/chipseq.nf | 5 ++--- 3 files changed, 11 insertions(+), 4 deletions(-) diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index 9c8c46f8c..45d770f8e 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -7,7 +7,7 @@ class WorkflowChipseq { // // Check and validate parameters // - public static void initialise(params, log) { + public static void initialise(params, log, valid_params) { genomeExistsError(params, log) if (!params.fasta) { @@ -27,6 +27,13 @@ class WorkflowChipseq { if (!params.macs_gsize) { macsGsizeWarn(log) } + + if (!params.aligner) { + if (!valid_params['aligners'].contains(params.aligner)) { + log.error "Invalid option: '${params.aligner}'. Valid options for '--aligner': ${valid_params['aligners'].join(', ')}." + System.exit(1) + } + } } // diff --git a/main.nf b/main.nf index 2ef142eea..a1cd575a4 100755 --- a/main.nf +++ b/main.nf @@ -21,6 +21,7 @@ params.fasta = WorkflowMain.getGenomeAttribute(params, 'fasta') params.bwa_index = WorkflowMain.getGenomeAttribute(params, 'bwa') params.bowtie2_index = WorkflowMain.getGenomeAttribute(params, 'bowtie2') params.chromap_index = WorkflowMain.getGenomeAttribute(params, 'chromap') +params.star_index = WorkflowMain.getGenomeAttribute(params, 'star') params.gtf = WorkflowMain.getGenomeAttribute(params, 'gtf') params.gff = WorkflowMain.getGenomeAttribute(params, 'gff') params.gene_bed = WorkflowMain.getGenomeAttribute(params, 'gene_bed') diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index c8cf7bcc7..843099a25 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -11,15 +11,14 @@ def valid_params = [ def summary_params = NfcoreSchema.paramsSummaryMap(workflow, params) // Validate input parameters -WorkflowChipseq.initialise(params, log) -// WorkflowChipseq.initialise(params, log, valid_params) //TODO include valid_params +WorkflowChipseq.initialise(params, log, valid_params) // Check input path parameters to see if they exist def checkPathParamList = [ params.input, params.multiqc_config, params.fasta, params.gtf, params.gff, params.gene_bed, - params.bwa_index, //TODO change now more aligners + params.bwa_index, params.bowtie2_index, params.chromap_index, params.star_index, params.blacklist, params.bamtools_filter_pe_config, params.bamtools_filter_se_config ] From dc96ba2b4fd5c33d96b7f6bdefaa7c5365bda42b Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 20 Jan 2022 22:24:28 +0100 Subject: [PATCH 297/538] Update chromap modules --- modules.json | 4 ++-- modules/nf-core/modules/chromap/chromap/main.nf | 16 ++++++++-------- modules/nf-core/modules/chromap/index/main.nf | 12 +++++------- 3 files changed, 15 insertions(+), 17 deletions(-) diff --git a/modules.json b/modules.json index d247eaf43..d509ccc1d 100644 --- a/modules.json +++ b/modules.json @@ -16,10 +16,10 @@ "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, "chromap/chromap": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "9573e7e53de808736ab691ed7f4ed3d9758d62b1" }, "chromap/index": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + "git_sha": "4e9cc84514651d5c3d5e13c5bd5ef5fc133e3989" }, "custom/dumpsoftwareversions": { "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" diff --git a/modules/nf-core/modules/chromap/chromap/main.nf b/modules/nf-core/modules/chromap/chromap/main.nf index 4a7f00974..67384b0ca 100644 --- a/modules/nf-core/modules/chromap/chromap/main.nf +++ b/modules/nf-core/modules/chromap/chromap/main.nf @@ -1,13 +1,11 @@ -def VERSION = '0.1' // Version information not provided by tool on CLI - process CHROMAP_CHROMAP { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? "bioconda::chromap=0.1 bioconda::samtools=1.13" : null) + conda (params.enable_conda ? "bioconda::chromap=0.1.5 bioconda::samtools=1.14" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:2cad7c5aa775241887eff8714259714a39baf016-0' : - 'quay.io/biocontainers/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:2cad7c5aa775241887eff8714259714a39baf016-0' }" + 'https://depot.galaxyproject.org/singularity/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:724a1037d59f6a19c9d4e7bdba77b52b37de0dc3-0' : + 'quay.io/biocontainers/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:724a1037d59f6a19c9d4e7bdba77b52b37de0dc3-0' }" input: tuple val(meta), path(reads) @@ -45,7 +43,7 @@ process CHROMAP_CHROMAP { args_list << "--pairs-natural-chr-order $pairs_chr_order" } def final_args = args_list.join(' ') - def compression_cmds = "gzip ${prefix}.${file_extension}" + def compression_cmds = "gzip -n ${prefix}.${file_extension}" if (args.contains("--SAM")) { compression_cmds = """ samtools view $args2 -@ $task.cpus -bh \\ @@ -67,7 +65,8 @@ process CHROMAP_CHROMAP { cat <<-END_VERSIONS > versions.yml "${task.process}": - chromap: $VERSION + chromap: \$(echo \$(chromap --version 2>&1)) + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS """ } else { @@ -85,7 +84,8 @@ process CHROMAP_CHROMAP { cat <<-END_VERSIONS > versions.yml "${task.process}": - chromap: $VERSION + chromap: \$(echo \$(chromap --version 2>&1)) + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS """ } diff --git a/modules/nf-core/modules/chromap/index/main.nf b/modules/nf-core/modules/chromap/index/main.nf index cafeca2fb..61bcee108 100644 --- a/modules/nf-core/modules/chromap/index/main.nf +++ b/modules/nf-core/modules/chromap/index/main.nf @@ -1,13 +1,12 @@ -def VERSION = '0.1' // Version information not provided by tool on CLI - process CHROMAP_INDEX { tag '$fasta' label 'process_medium' - conda (params.enable_conda ? "bioconda::chromap=0.1 bioconda::samtools=1.13" : null) + conda (params.enable_conda ? "bioconda::chromap=0.1.5" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:2cad7c5aa775241887eff8714259714a39baf016-0' : - 'quay.io/biocontainers/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:2cad7c5aa775241887eff8714259714a39baf016-0' }" + 'https://depot.galaxyproject.org/singularity/chromap:0.1.5--h9a82719_0' : + 'quay.io/biocontainers/chromap:0.1.5--h9a82719_0' }" + input: path fasta @@ -29,8 +28,7 @@ process CHROMAP_INDEX { cat <<-END_VERSIONS > versions.yml "${task.process}": - chromap: $VERSION - samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + chromap: \$(echo \$(chromap --version 2>&1)) END_VERSIONS """ } From 9b7a45c91a86d86b4b4ce1d09de236ce52b7761e Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 20 Jan 2022 22:35:11 +0100 Subject: [PATCH 298/538] Add save_unaligned parameter --- conf/modules.config | 10 ++++++---- nextflow.config | 1 + nextflow_schema.json | 7 +++++++ workflows/chipseq.nf | 8 ++++---- 4 files changed, 18 insertions(+), 8 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index c332fe249..54886e794 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -254,8 +254,8 @@ if (params.aligner == 'star') { '--readFilesCommand zcat', '--runRNGseed 0', // '--outFilterMultimapNmax 20', //DEL - '--outSAMattributes NH HI AS NM MD' - // params.save_unaligned ? '--outReadsUnmapped Fastx' : '' //TODO + '--outSAMattributes NH HI AS NM MD', + params.save_unaligned ? '--outReadsUnmapped Fastx' : '' ].join(' ').trim() publishDir = [ [ @@ -267,13 +267,15 @@ if (params.aligner == 'star') { path: { "${params.outdir}/${params.aligner}" }, mode: 'copy', pattern: '*.bam', - // enabled: params.save_align_intermeds //TODO + // TODO + // enabled: params.save_align_intermeds + enabled: false ], [ path: { "${params.outdir}/${params.aligner}/unmapped" }, mode: 'copy', pattern: '*.fastq.gz', - // enabled: params.save_unaligned //TODO + enabled: params.save_unaligned ] ] } diff --git a/nextflow.config b/nextflow.config index 8f8157fc7..d5683b804 100644 --- a/nextflow.config +++ b/nextflow.config @@ -35,6 +35,7 @@ params { keep_dups = false keep_multi_map = false save_align_intermeds = false + save_unaligned = false // Options: Peaks narrow_peak = false diff --git a/nextflow_schema.json b/nextflow_schema.json index fb677cd35..92fbc23b7 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -233,6 +233,12 @@ "help_text": "By default, intermediate BAM files will not be saved. The final BAM files created after the appropriate filtering step are always saved to limit storage usage. Set this parameter to also save other intermediate BAM files.", "fa_icon": "fas fa-save" }, + "save_unaligned": { + "type": "boolean", + "fa_icon": "fas fa-save", + "description": "Where possible, save unaligned reads from either STAR, HISAT2 or Salmon to the results directory.", + "help_text": "This may either be in the form of FastQ or BAM files depending on the options available for that particular tool." + }, "bamtools_filter_pe_config": { "type": "string", "default": "$projectDir/assets/bamtools_filter_pe.json", @@ -247,6 +253,7 @@ "description": "BAMTools JSON file with custom filters for single-end data.", "fa_icon": "fas fa-cog" } + } }, "peak_calling_options": { diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 843099a25..b4a18c4b0 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -184,7 +184,7 @@ workflow CHIPSEQ { ch_samtools_idxstats = ALIGN_BWA_MEM.out.idxstats ch_versions = ch_versions.mix(ALIGN_BWA_MEM.out.versions.first()) } - params.save_unaligned = false + if (params.aligner == 'bowtie2') { ALIGN_BOWTIE2 ( FASTQC_TRIMGALORE.out.reads, @@ -207,9 +207,9 @@ workflow CHIPSEQ { ) ch_genome_bam = ALIGN_CHROMAP.out.bam ch_genome_bam_index = ALIGN_CHROMAP.out.bai - // ch_samtools_stats = ALIGN_CHROMAP.out.stats //TODO - // ch_samtools_flagstat = ALIGN_CHROMAP.out.flagstat - // ch_samtools_idxstats = ALIGN_CHROMAP.out.idxstats + ch_samtools_stats = ALIGN_CHROMAP.out.stats //TODO + ch_samtools_flagstat = ALIGN_CHROMAP.out.flagstat + ch_samtools_idxstats = ALIGN_CHROMAP.out.idxstats ch_versions = ch_versions.mix(ALIGN_CHROMAP.out.versions.first()) } From 87243d7718648a35e6ae2d5703abddf680631b80 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 20 Jan 2022 22:58:51 +0100 Subject: [PATCH 299/538] Add --SAM argument to chromap --- conf/modules.config | 5 ++++- 1 file changed, 4 insertions(+), 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index 54886e794..d0fab3fe9 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -227,7 +227,10 @@ if (params.aligner == 'chromap') { ] } withName: CHROMAP_CHROMAP { - ext.args = '--preset chip' + ext.args = [ + '--preset chip', + '--SAM' + ].join(' ').trim() ext.prefix = { "${meta.id}.Lb" } publishDir = [ path: { "${params.outdir}/${params.aligner}/library" }, From a57d582808112bdc26cfa018cf4be8e49ecf3f03 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 21 Jan 2022 10:12:26 +0100 Subject: [PATCH 300/538] Fix typo in checking valid aligners --- lib/WorkflowChipseq.groovy | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index 45d770f8e..7e3954648 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -28,7 +28,7 @@ class WorkflowChipseq { macsGsizeWarn(log) } - if (!params.aligner) { + if (params.aligner) { if (!valid_params['aligners'].contains(params.aligner)) { log.error "Invalid option: '${params.aligner}'. Valid options for '--aligner': ${valid_params['aligners'].join(', ')}." System.exit(1) From 56b07830029ce5a09b8e6007b1e6d121f43ab67e Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 24 Jan 2022 09:33:47 +0100 Subject: [PATCH 301/538] Update star align config --- conf/modules.config | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index d0fab3fe9..3e8edb876 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -253,10 +253,12 @@ if (params.aligner == 'star') { } withName: '.*:ALIGN_STAR:STAR_ALIGN' { ext.args = [ + '--runMode alignReads', + '--alignIntronMax 1', + '--alignEndsType EndToEnd', '--outSAMtype BAM Unsorted', '--readFilesCommand zcat', '--runRNGseed 0', - // '--outFilterMultimapNmax 20', //DEL '--outSAMattributes NH HI AS NM MD', params.save_unaligned ? '--outReadsUnmapped Fastx' : '' ].join(' ').trim() From c2e9e680e165b6bf6b6f6d0db93317cfb5d2d2b2 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 24 Jan 2022 10:10:59 +0100 Subject: [PATCH 302/538] Fix typo in star_index emission --- subworkflows/local/prepare_genome.nf | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index 5d27d756b..98da8e23e 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -17,7 +17,7 @@ include { CHROMAP_INDEX } from '../../modules/nf-core/modules/chromap/ind include { GTF2BED } from '../../modules/local/gtf2bed' include { GENOME_BLACKLIST_REGIONS } from '../../modules/local/genome_blacklist_regions' -include { STAR_GENOMEGENERATE } from '../../modules/local/star_genomegenerate' +include { STAR_GENOMEGENERATE } from '../../modules/local/star_genomegenerate' workflow PREPARE_GENOME { take: @@ -194,7 +194,7 @@ workflow PREPARE_GENOME { bwa_index = ch_bwa_index // path: bwa/index/ bowtie2_index = ch_bowtie2_index // path: bowtie2/index/ chromap_index = ch_chromap_index // path: genome.index - star_index = ch_chromap_index // path: star/index/ + star_index = ch_star_index // path: star/index/ versions = ch_versions.ifEmpty(null) // channel: [ versions.yml ] } From 8b387ce6d5558044993b089cf7eb9d627f3d3fa1 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 24 Jan 2022 11:40:09 +0100 Subject: [PATCH 303/538] Update star modules --- modules/local/star_align.nf | 3 --- modules/local/star_genomegenerate.nf | 28 ++++++++++------------------ workflows/chipseq.nf | 2 +- 3 files changed, 11 insertions(+), 22 deletions(-) diff --git a/modules/local/star_align.nf b/modules/local/star_align.nf index 5a67b1716..0eef958db 100644 --- a/modules/local/star_align.nf +++ b/modules/local/star_align.nf @@ -43,9 +43,7 @@ process STAR_ALIGN { $ignore_gtf \\ $seq_center \\ $args - $mv_unsorted_bam - if [ -f ${prefix}.Unmapped.out.mate1 ]; then mv ${prefix}.Unmapped.out.mate1 ${prefix}.unmapped_1.fastq gzip ${prefix}.unmapped_1.fastq @@ -54,7 +52,6 @@ process STAR_ALIGN { mv ${prefix}.Unmapped.out.mate2 ${prefix}.unmapped_2.fastq gzip ${prefix}.unmapped_2.fastq fi - cat <<-END_VERSIONS > versions.yml "${task.process}": star: \$(STAR --version | sed -e "s/STAR_//g") diff --git a/modules/local/star_genomegenerate.nf b/modules/local/star_genomegenerate.nf index ad32c0dd8..3cd4ff20c 100644 --- a/modules/local/star_genomegenerate.nf +++ b/modules/local/star_genomegenerate.nf @@ -3,24 +3,23 @@ process STAR_GENOMEGENERATE { label 'process_high' // Note: 2.7X indices incompatible with AWS iGenomes. - conda (params.enable_conda ? "bioconda::star=2.7.9a bioconda::samtools=1.13 conda-forge::gawk=5.1.0" : null) + conda (params.enable_conda ? "bioconda::star=2.6.1d bioconda::samtools=1.10 conda-forge::gawk=5.1.0" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/mulled-v2-1fa26d1ce03c295fe2fdcf85831a92fbcbd7e8c2:a7908dfb0485a80ca94e4d17b0ac991532e4e989-0' : - 'quay.io/biocontainers/mulled-v2-1fa26d1ce03c295fe2fdcf85831a92fbcbd7e8c2:a7908dfb0485a80ca94e4d17b0ac991532e4e989-0' }" + 'https://depot.galaxyproject.org/singularity/mulled-v2-1fa26d1ce03c295fe2fdcf85831a92fbcbd7e8c2:59cdd445419f14abac76b31dd0d71217994cbcc9-0' : + 'quay.io/biocontainers/mulled-v2-1fa26d1ce03c295fe2fdcf85831a92fbcbd7e8c2:59cdd445419f14abac76b31dd0d71217994cbcc9-0' }" input: path fasta path gtf output: - path "star" , emit: index - path "versions.yml" , emit: versions + path "star" , emit: index + path "versions.yml", emit: versions script: - def args = task.ext.args ?: '' - def args_list = args.tokenize() - def memory = task.memory ? "--limitGenomeGenerateRAM ${task.memory.toBytes() - 100000000}" : '' - if (args_list.contains('--genomeSAindexNbases')) { + def args = (task.ext.args ?: '').tokenize() + def memory = task.memory ? "--limitGenomeGenerateRAM ${task.memory.toBytes() - 100000000}" : '' + if (args.contains('--genomeSAindexNbases')) { """ mkdir star STAR \\ @@ -30,20 +29,16 @@ process STAR_GENOMEGENERATE { --sjdbGTFfile $gtf \\ --runThreadN $task.cpus \\ $memory \\ - $args - + ${args.join(' ')} cat <<-END_VERSIONS > versions.yml "${task.process}": star: \$(STAR --version | sed -e "s/STAR_//g") - samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') - gawk: \$(echo \$(gawk --version 2>&1) | sed 's/^.*GNU Awk //; s/, .*\$//') END_VERSIONS """ } else { """ samtools faidx $fasta NUM_BASES=`gawk '{sum = sum + \$2}END{if ((log(sum)/log(2))/2 - 1 > 14) {printf "%.0f", 14} else {printf "%.0f", (log(sum)/log(2))/2 - 1}}' ${fasta}.fai` - mkdir star STAR \\ --runMode genomeGenerate \\ @@ -53,13 +48,10 @@ process STAR_GENOMEGENERATE { --runThreadN $task.cpus \\ --genomeSAindexNbases \$NUM_BASES \\ $memory \\ - $args - + ${args.join(' ')} cat <<-END_VERSIONS > versions.yml "${task.process}": star: \$(STAR --version | sed -e "s/STAR_//g") - samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') - gawk: \$(echo \$(gawk --version 2>&1) | sed 's/^.*GNU Awk //; s/, .*\$//') END_VERSIONS """ } diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index b4a18c4b0..621613a78 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -217,7 +217,7 @@ workflow CHIPSEQ { ALIGN_STAR ( FASTQC_TRIMGALORE.out.reads, PREPARE_GENOME.out.star_index, - params.save_unaligned + [] ) ch_genome_bam = ALIGN_STAR.out.bam ch_genome_bam_index = ALIGN_STAR.out.bai From ec806d21a194005b419d1eb26c1221380516e7cc Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 24 Jan 2022 12:18:10 +0100 Subject: [PATCH 304/538] Remove gtf from star --- modules/local/star_align.nf | 3 --- workflows/chipseq.nf | 3 +-- 2 files changed, 1 insertion(+), 5 deletions(-) diff --git a/modules/local/star_align.nf b/modules/local/star_align.nf index 0eef958db..f960045f3 100644 --- a/modules/local/star_align.nf +++ b/modules/local/star_align.nf @@ -11,7 +11,6 @@ process STAR_ALIGN { input: tuple val(meta), path(reads) path index - path gtf output: tuple val(meta), path('*d.out.bam') , emit: bam @@ -29,7 +28,6 @@ process STAR_ALIGN { script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" - def ignore_gtf = params.star_ignore_sjdbgtf ? '' : "--sjdbGTFfile $gtf" def seq_center = params.seq_center ? "--outSAMattrRGline ID:$prefix 'CN:$params.seq_center' 'SM:$prefix'" : "--outSAMattrRGline ID:$prefix 'SM:$prefix'" def out_sam_type = (args.contains('--outSAMtype')) ? '' : '--outSAMtype BAM Unsorted' def mv_unsorted_bam = (args.contains('--outSAMtype BAM Unsorted SortedByCoordinate')) ? "mv ${prefix}.Aligned.out.bam ${prefix}.Aligned.unsort.out.bam" : '' @@ -40,7 +38,6 @@ process STAR_ALIGN { --runThreadN $task.cpus \\ --outFileNamePrefix $prefix. \\ $out_sam_type \\ - $ignore_gtf \\ $seq_center \\ $args $mv_unsorted_bam diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 621613a78..b83884883 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -216,8 +216,7 @@ workflow CHIPSEQ { if (params.aligner == 'star') { ALIGN_STAR ( FASTQC_TRIMGALORE.out.reads, - PREPARE_GENOME.out.star_index, - [] + PREPARE_GENOME.out.star_index ) ch_genome_bam = ALIGN_STAR.out.bam ch_genome_bam_index = ALIGN_STAR.out.bai From 67b45fd3a2aa5b85ed5c09ac6b2e6656c98ef19c Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 24 Jan 2022 12:20:28 +0100 Subject: [PATCH 305/538] Remove gtf file from align_star --- subworkflows/nf-core/align_star.nf | 1 - 1 file changed, 1 deletion(-) diff --git a/subworkflows/nf-core/align_star.nf b/subworkflows/nf-core/align_star.nf index 248efe40f..568889b33 100644 --- a/subworkflows/nf-core/align_star.nf +++ b/subworkflows/nf-core/align_star.nf @@ -9,7 +9,6 @@ workflow ALIGN_STAR { take: reads // channel: [ val(meta), [ reads ] ] index // channel: /path/to/star/index/ - gtf // channel: /path/to/genome.gtf main: From f6a8e56e0cad4901262a7e4c560b7a059db68f9a Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 24 Jan 2022 12:24:31 +0100 Subject: [PATCH 306/538] Remove gtf from call to star_align argggg! --- subworkflows/nf-core/align_star.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/subworkflows/nf-core/align_star.nf b/subworkflows/nf-core/align_star.nf index 568889b33..2f3527e05 100644 --- a/subworkflows/nf-core/align_star.nf +++ b/subworkflows/nf-core/align_star.nf @@ -17,7 +17,7 @@ workflow ALIGN_STAR { // // Map reads with STAR // - STAR_ALIGN ( reads, index, gtf ) + STAR_ALIGN ( reads, index ) ch_versions = ch_versions.mix(STAR_ALIGN.out.versions.first()) // From 0c3e7c453c5d92339348084af9aeedaf676456e2 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 25 Jan 2022 16:14:16 +0100 Subject: [PATCH 307/538] Remove chromap modules --- modules.json | 6 -- .../nf-core/modules/chromap/chromap/main.nf | 92 ------------------- .../nf-core/modules/chromap/chromap/meta.yml | 88 ------------------ modules/nf-core/modules/chromap/index/main.nf | 34 ------- .../nf-core/modules/chromap/index/meta.yml | 33 ------- 5 files changed, 253 deletions(-) delete mode 100644 modules/nf-core/modules/chromap/chromap/main.nf delete mode 100644 modules/nf-core/modules/chromap/chromap/meta.yml delete mode 100644 modules/nf-core/modules/chromap/index/main.nf delete mode 100644 modules/nf-core/modules/chromap/index/meta.yml diff --git a/modules.json b/modules.json index d509ccc1d..135a6859f 100644 --- a/modules.json +++ b/modules.json @@ -15,12 +15,6 @@ "bwa/mem": { "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" }, - "chromap/chromap": { - "git_sha": "9573e7e53de808736ab691ed7f4ed3d9758d62b1" - }, - "chromap/index": { - "git_sha": "4e9cc84514651d5c3d5e13c5bd5ef5fc133e3989" - }, "custom/dumpsoftwareversions": { "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" }, diff --git a/modules/nf-core/modules/chromap/chromap/main.nf b/modules/nf-core/modules/chromap/chromap/main.nf deleted file mode 100644 index 67384b0ca..000000000 --- a/modules/nf-core/modules/chromap/chromap/main.nf +++ /dev/null @@ -1,92 +0,0 @@ -process CHROMAP_CHROMAP { - tag "$meta.id" - label 'process_medium' - - conda (params.enable_conda ? "bioconda::chromap=0.1.5 bioconda::samtools=1.14" : null) - container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:724a1037d59f6a19c9d4e7bdba77b52b37de0dc3-0' : - 'quay.io/biocontainers/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:724a1037d59f6a19c9d4e7bdba77b52b37de0dc3-0' }" - - input: - tuple val(meta), path(reads) - path fasta - path index - path barcodes - path whitelist - path chr_order - path pairs_chr_order - - output: - tuple val(meta), path("*.bed.gz") , optional:true, emit: bed - tuple val(meta), path("*.bam") , optional:true, emit: bam - tuple val(meta), path("*.tagAlign.gz"), optional:true, emit: tagAlign - tuple val(meta), path("*.pairs.gz") , optional:true, emit: pairs - path "versions.yml" , emit: versions - - script: - def args = task.ext.args ?: '' - def args2 = task.ext.args2 ?: '' - def prefix = task.ext.prefix ?: "${meta.id}" - def args_list = args.tokenize() - - def file_extension = args.contains("--SAM") ? 'sam' : args.contains("--TagAlign")? 'tagAlign' : args.contains("--pairs")? 'pairs' : 'bed' - if (barcodes) { - args_list << "-b ${barcodes.join(',')}" - if (whitelist) { - args_list << "--barcode-whitelist $whitelist" - } - } - if (chr_order) { - args_list << "--chr-order $chr_order" - } - if (pairs_chr_order){ - args_list << "--pairs-natural-chr-order $pairs_chr_order" - } - def final_args = args_list.join(' ') - def compression_cmds = "gzip -n ${prefix}.${file_extension}" - if (args.contains("--SAM")) { - compression_cmds = """ - samtools view $args2 -@ $task.cpus -bh \\ - -o ${prefix}.bam ${prefix}.${file_extension} - rm ${prefix}.${file_extension} - """ - } - if (meta.single_end) { - """ - chromap \\ - $final_args \\ - -t $task.cpus \\ - -x $index \\ - -r $fasta \\ - -1 ${reads.join(',')} \\ - -o ${prefix}.${file_extension} - - $compression_cmds - - cat <<-END_VERSIONS > versions.yml - "${task.process}": - chromap: \$(echo \$(chromap --version 2>&1)) - samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') - END_VERSIONS - """ - } else { - """ - chromap \\ - $final_args \\ - -t $task.cpus \\ - -x $index \\ - -r $fasta \\ - -1 ${reads[0]} \\ - -2 ${reads[1]} \\ - -o ${prefix}.${file_extension} - - $compression_cmds - - cat <<-END_VERSIONS > versions.yml - "${task.process}": - chromap: \$(echo \$(chromap --version 2>&1)) - samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') - END_VERSIONS - """ - } -} diff --git a/modules/nf-core/modules/chromap/chromap/meta.yml b/modules/nf-core/modules/chromap/chromap/meta.yml deleted file mode 100644 index 57936c673..000000000 --- a/modules/nf-core/modules/chromap/chromap/meta.yml +++ /dev/null @@ -1,88 +0,0 @@ -name: chromap_chromap -description: | - Performs preprocessing and alignment of chromatin fastq files to - fasta reference files using chromap. -keywords: - - chromap - - alignment - - map - - fastq - - bam - - sam - - hi-c - - atac-seq - - chip-seq - - trimming - - duplicate removal -tools: - - chromap: - description: Fast alignment and preprocessing of chromatin profiles - homepage: https://github.com/haowenz/chromap - documentation: https://github.com/haowenz/chromap - tool_dev_url: https://github.com/haowenz/chromap - doi: "" - licence: ['GPL v3'] -input: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - reads: - type: file - description: | - List of input FastQ files of size 1 and 2 for single-end and paired-end data, - respectively. - - fasta: - type: file - description: | - The fasta reference file. - - index: - type: file - description: | - Chromap genome index files (*.index) - - barcodes: - type: file - description: | - Cell barcode files - - whitelist: - type: file - description: | - Cell barcode whitelist file - - chr_order: - type: file - description: | - Custom chromosome order - - pairs_chr_order: - type: file - description: | - Natural chromosome order for pairs flipping -output: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" - - bed: - type: file - description: BED file - pattern: "*.bed.gz" - - bam: - type: file - description: BAM file - pattern: "*.bam" - - tagAlign: - type: file - description: tagAlign file - pattern: "*.tagAlign.gz" - - pairs: - type: file - description: pairs file - pattern: "*.pairs.gz" - -authors: - - "@mahesh-panchal" diff --git a/modules/nf-core/modules/chromap/index/main.nf b/modules/nf-core/modules/chromap/index/main.nf deleted file mode 100644 index 61bcee108..000000000 --- a/modules/nf-core/modules/chromap/index/main.nf +++ /dev/null @@ -1,34 +0,0 @@ -process CHROMAP_INDEX { - tag '$fasta' - label 'process_medium' - - conda (params.enable_conda ? "bioconda::chromap=0.1.5" : null) - container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/chromap:0.1.5--h9a82719_0' : - 'quay.io/biocontainers/chromap:0.1.5--h9a82719_0' }" - - - input: - path fasta - - output: - path "*.index" , emit: index - path "versions.yml", emit: versions - - script: - def args = task.ext.args ?: '' - def prefix = fasta.baseName - """ - chromap \\ - -i \\ - $args \\ - -t $task.cpus \\ - -r $fasta \\ - -o ${prefix}.index - - cat <<-END_VERSIONS > versions.yml - "${task.process}": - chromap: \$(echo \$(chromap --version 2>&1)) - END_VERSIONS - """ -} diff --git a/modules/nf-core/modules/chromap/index/meta.yml b/modules/nf-core/modules/chromap/index/meta.yml deleted file mode 100644 index a6a18fe9d..000000000 --- a/modules/nf-core/modules/chromap/index/meta.yml +++ /dev/null @@ -1,33 +0,0 @@ -name: chromap_index -description: Indexes a fasta reference genome ready for chromatin profiling. -keywords: - - index - - fasta - - genome - - reference -tools: - - chromap: - description: Fast alignment and preprocessing of chromatin profiles - homepage: https://github.com/haowenz/chromap - documentation: https://github.com/haowenz/chromap - tool_dev_url: https://github.com/haowenz/chromap - doi: "" - licence: ['GPL v3'] - -input: - - fasta: - type: file - description: Fasta reference file. - -output: - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" - - index: - type: file - description: Index file of the reference genome - pattern: "*.{index}" - -authors: - - "@mahesh-panchal" From 2e81cdcd4844379203c4f7068ab995f3b52c5108 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 25 Jan 2022 16:26:15 +0100 Subject: [PATCH 308/538] Discard by the moment chromap --- conf/modules.config | 25 ------------------ main.nf | 1 - nextflow_schema.json | 6 ----- subworkflows/local/prepare_genome.nf | 20 -------------- subworkflows/nf-core/align_chromap.nf | 38 --------------------------- workflows/chipseq.nf | 19 ++------------ 6 files changed, 2 insertions(+), 107 deletions(-) delete mode 100644 subworkflows/nf-core/align_chromap.nf diff --git a/conf/modules.config b/conf/modules.config index 3e8edb876..9aaacdf05 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -216,31 +216,6 @@ if (params.aligner == 'bowtie2') { } } -if (params.aligner == 'chromap') { - process { - withName: CHROMAP_INDEX { - ext.args = '' - publishDir = [ - path: { "${params.outdir}/genome/${params.aligner}/index" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - withName: CHROMAP_CHROMAP { - ext.args = [ - '--preset chip', - '--SAM' - ].join(' ').trim() - ext.prefix = { "${meta.id}.Lb" } - publishDir = [ - path: { "${params.outdir}/${params.aligner}/library" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - } -} - if (params.aligner == 'star') { process { withName: STAR_GENOMEGENERATE { diff --git a/main.nf b/main.nf index a1cd575a4..ec4dc6471 100755 --- a/main.nf +++ b/main.nf @@ -20,7 +20,6 @@ nextflow.enable.dsl = 2 params.fasta = WorkflowMain.getGenomeAttribute(params, 'fasta') params.bwa_index = WorkflowMain.getGenomeAttribute(params, 'bwa') params.bowtie2_index = WorkflowMain.getGenomeAttribute(params, 'bowtie2') -params.chromap_index = WorkflowMain.getGenomeAttribute(params, 'chromap') params.star_index = WorkflowMain.getGenomeAttribute(params, 'star') params.gtf = WorkflowMain.getGenomeAttribute(params, 'gtf') params.gff = WorkflowMain.getGenomeAttribute(params, 'gff') diff --git a/nextflow_schema.json b/nextflow_schema.json index 92fbc23b7..78ebbd4bb 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -105,12 +105,6 @@ "fa_icon": "fas fa-bezier-curve", "description": "Path to directory or tar.gz archive for pre-built Bowtie2 index." }, - "chromap_index": { - "type": "string", - "format": "path", - "fa_icon": "fas fa-bezier-curve", - "description": "Path to directory or tar.gz archive for pre-built Chromap index." - }, "star_index": { "type": "string", "format": "path", diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index 98da8e23e..a4e1be85f 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -13,7 +13,6 @@ include { GFFREAD } from '../../modules/nf-core/modules/gffread/mai include { CUSTOM_GETCHROMSIZES } from '../../modules/nf-core/modules/custom/getchromsizes/main' include { BWA_INDEX } from '../../modules/nf-core/modules/bwa/index/main' include { BOWTIE2_BUILD } from '../../modules/nf-core/modules/bowtie2/build/main' -include { CHROMAP_INDEX } from '../../modules/nf-core/modules/chromap/index/main' include { GTF2BED } from '../../modules/local/gtf2bed' include { GENOME_BLACKLIST_REGIONS } from '../../modules/local/genome_blacklist_regions' @@ -149,24 +148,6 @@ workflow PREPARE_GENOME { } } - // - // Uncompress CHROMAP index or generate from scratch if required - // - ch_chromap_index = Channel.empty() - if (prepare_tool_index == 'chromap') { - if (params.chromap_index) { - if (params.chromap_index.endsWith('.tar.gz')) { - ch_chromap_index = UNTAR ( params.chromap_index ).untar - ch_versions = ch_versions.mix(UNTAR.out.versions) - } else { - ch_chromap_index = file(params.chromap_index) - } - } else { - ch_chromap_index = CHROMAP_INDEX ( ch_fasta ).index - ch_versions = ch_versions.mix(CHROMAP_INDEX.out.versions) - } - } - // // Uncompress STAR index or generate from scratch if required // @@ -193,7 +174,6 @@ workflow PREPARE_GENOME { blacklist = ch_blacklist // path: blacklist.bed bwa_index = ch_bwa_index // path: bwa/index/ bowtie2_index = ch_bowtie2_index // path: bowtie2/index/ - chromap_index = ch_chromap_index // path: genome.index star_index = ch_star_index // path: star/index/ versions = ch_versions.ifEmpty(null) // channel: [ versions.yml ] diff --git a/subworkflows/nf-core/align_chromap.nf b/subworkflows/nf-core/align_chromap.nf deleted file mode 100644 index 5afa99bc2..000000000 --- a/subworkflows/nf-core/align_chromap.nf +++ /dev/null @@ -1,38 +0,0 @@ -/* - * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats - */ - -include { CHROMAP_CHROMAP } from '../../modules/nf-core/modules/chromap/chromap/main' -include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' - -workflow ALIGN_CHROMAP { - take: - reads // channel: [ val(meta), [ reads ] ] - index // path: /path/to/index - fasta // path: /path/to/fasta - - main: - - ch_versions = Channel.empty() - - // - // Map reads with CHROMAP - // - CHROMAP_CHROMAP(reads, fasta, index, [], [], [], []) - ch_versions = ch_versions.mix(CHROMAP_CHROMAP.out.versions.first()) - - // - // Sort, index BAM file and run samtools stats, flagstat and idxstats - // - BAM_SORT_SAMTOOLS(CHROMAP_CHROMAP.out.bam) - ch_versions = ch_versions.mix(BAM_SORT_SAMTOOLS.out.versions.first()) - - emit: - bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] - bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] - stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] - flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] - idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] - - versions = ch_versions // path: versions.yml -} diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index b83884883..92c0f747e 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -5,7 +5,7 @@ */ def valid_params = [ - aligners : [ 'bwa', 'bowtie2', 'chromap', 'star' ] + aligners : [ 'bwa', 'bowtie2', 'star' ] ] def summary_params = NfcoreSchema.paramsSummaryMap(workflow, params) @@ -18,7 +18,7 @@ def checkPathParamList = [ params.input, params.multiqc_config, params.fasta, params.gtf, params.gff, params.gene_bed, - params.bwa_index, params.bowtie2_index, params.chromap_index, params.star_index, + params.bwa_index, params.bowtie2_index, params.star_index, params.blacklist, params.bamtools_filter_pe_config, params.bamtools_filter_se_config ] @@ -117,7 +117,6 @@ include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../module include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' include { ALIGN_BWA_MEM } from '../subworkflows/nf-core/align_bwa_mem' -include { ALIGN_CHROMAP } from '../subworkflows/nf-core/align_chromap' include { ALIGN_BOWTIE2 } from '../subworkflows/nf-core/align_bowtie2' include { ALIGN_STAR } from '../subworkflows/nf-core/align_star' include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' @@ -199,20 +198,6 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(ALIGN_BOWTIE2.out.versions.first()) } - if (params.aligner == 'chromap') { - ALIGN_CHROMAP ( - FASTQC_TRIMGALORE.out.reads, - PREPARE_GENOME.out.chromap_index, - PREPARE_GENOME.out.fasta - ) - ch_genome_bam = ALIGN_CHROMAP.out.bam - ch_genome_bam_index = ALIGN_CHROMAP.out.bai - ch_samtools_stats = ALIGN_CHROMAP.out.stats //TODO - ch_samtools_flagstat = ALIGN_CHROMAP.out.flagstat - ch_samtools_idxstats = ALIGN_CHROMAP.out.idxstats - ch_versions = ch_versions.mix(ALIGN_CHROMAP.out.versions.first()) - } - if (params.aligner == 'star') { ALIGN_STAR ( FASTQC_TRIMGALORE.out.reads, From e69c3dac651707fd926e74bfabe6f4528df76190 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 26 Jan 2022 08:38:37 +0100 Subject: [PATCH 309/538] Add aligner parameter to schema --- nextflow_schema.json | 11 +++++++++++ 1 file changed, 11 insertions(+) diff --git a/nextflow_schema.json b/nextflow_schema.json index 78ebbd4bb..b3d1750fb 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -206,6 +206,17 @@ "fa_icon": "fas fa-map-signs", "description": "Options to adjust parameters and filtering criteria for read alignments.", "properties": { + "aligner": { + "type": "string", + "default": "bwa", + "description": "Specifies the alignment algorithm to use - available options are 'bwa', 'bowtie2' and 'star'.", + "fa_icon": "fas fa-map-signs", + "enum": [ + "bwa", + "bowtie2", + "star" + ] + }, "keep_dups": { "type": "boolean", "description": "Duplicate reads are not filtered from alignments.", From 145c163b9149a387bc6e78fb13fb35f8aa14f9bd Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 26 Jan 2022 10:16:11 +0100 Subject: [PATCH 310/538] Separate outputs by aligner --- conf/modules.config | 60 ++++++++++++++++++++++----------------------- 1 file changed, 30 insertions(+), 30 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 9aaacdf05..70d654a65 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -140,7 +140,7 @@ process { withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ - path: { "${params.outdir}/bwa/library" }, + path: { "${params.outdir}/${params.aligner}/library" }, mode: 'copy', pattern: "*.bam", enabled: params.save_align_intermeds @@ -150,7 +150,7 @@ process { // ext.args = params.bam_csi_index ? '-c' : '' ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ - path: { "${params.outdir}/bwa/library" }, + path: { "${params.outdir}/${params.aligner}/library" }, mode: 'copy', pattern: '*.{bai,csi}', enabled: params.save_align_intermeds @@ -160,7 +160,7 @@ process { // ext.args = params.bam_csi_index ? '-c' : '' ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ - path: { "${params.outdir}/bwa/library" }, + path: { "${params.outdir}/${params.aligner}/library" }, mode: 'copy', pattern: "*.{stats,flagstat,idxstats}", enabled: params.save_align_intermeds @@ -267,7 +267,7 @@ process { ext.args = 'SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' ext.prefix = { "${meta.id}.mLb.sorted" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -277,12 +277,12 @@ process { ext.prefix = { "${meta.id}.mLb.mkD.sorted" } publishDir = [ [ - path: { "${params.outdir}/bwa/mergedLibrary" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: 'copy', pattern: '*metrics.txt' ], [ - path: { "${params.outdir}/bwa/mergedLibrary" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: 'copy', pattern: '*.bam' ] @@ -292,14 +292,14 @@ process { // ext.args = params.bam_csi_index ? '-c' : '' // TODO implement it ext.prefix = { "${meta.id}.mkD.sorted" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: 'copy', pattern: '*.{bai,csi}' ] } withName: '.*:MARK_DUPLICATES_PICARD:BAM_STATS_SAMTOOLS:.*' { publishDir = [ - path: { "${params.outdir}/bwa/samtools_stats" }, + path: { "${params.outdir}/${params.aligner}/samtools_stats" }, mode: 'copy', pattern: '*.{stats,flagstat,idxstats}' ] @@ -307,7 +307,7 @@ process { withName: BAM_FILTER { ext.prefix = { "${meta.id}.mLb.flT.sorted" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -316,7 +316,7 @@ process { ext.args = '--only_fr_pairs' ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -324,7 +324,7 @@ process { withName: 'NFCORE_CHIPSEQ:CHIPSEQ:FILTER_BAM_BAMTOOLS:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: 'copy', pattern: '*.{bai,csi}' ] @@ -332,7 +332,7 @@ process { withName: 'NFCORE_CHIPSEQ:CHIPSEQ:FILTER_BAM_BAMTOOLS:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: 'copy', pattern: "*.bam" ] @@ -340,7 +340,7 @@ process { withName: 'NFCORE_CHIPSEQ:CHIPSEQ:FILTER_BAM_BAMTOOLS:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:.*' { ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ - path: { "${params.outdir}/bwa/library" }, + path: { "${params.outdir}/${params.aligner}/library" }, mode: 'copy', pattern: "*.{stats,flagstat,idxstats}" ] @@ -348,7 +348,7 @@ process { withName: PHANTOMPEAKQUALTOOLS { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/phantompeakqualtools" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/phantompeakqualtools" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -362,7 +362,7 @@ process { withName: BEDTOOLS_GENOMECOV { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/bigwig" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -370,7 +370,7 @@ process { withName: UCSC_BEDGRAPHTOBIGWIG { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/bigwig" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -383,7 +383,7 @@ if (!params.skip_picard_metrics) { ext.args = 'VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/picard_metrics" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/picard_metrics" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -397,7 +397,7 @@ if (!params.skip_preseq) { ext.args = '-verbose -bam -seed 1' ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/preseq" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/preseq" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -411,7 +411,7 @@ if (!params.skip_plot_profile) { ext.args = 'scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels' ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -419,7 +419,7 @@ if (!params.skip_plot_profile) { withName: DEEPTOOLS_PLOTPROFILE { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -427,7 +427,7 @@ if (!params.skip_plot_profile) { withName: DEEPTOOLS_PLOTHEATMAP { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -444,7 +444,7 @@ if (!params.skip_plot_fingerprint) { ].join(' ').trim() ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/bwa/mergedLibrary/deeptools" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -464,7 +464,7 @@ if (params.macs_gsize) { ].join(' ').trim() publishDir = [ path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, mode: 'copy', @@ -492,7 +492,7 @@ if (params.macs_gsize) { ext.args = '-o ./ -p macs2_peak' publishDir = [ path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, mode: 'copy', @@ -504,7 +504,7 @@ if (params.macs_gsize) { // ext.prefix = 'peaks' publishDir = [ path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, mode: 'copy', @@ -515,7 +515,7 @@ if (params.macs_gsize) { ext.args = '-o ./ -p macs2_annotatePeaks' publishDir = [ path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, mode: 'copy', @@ -531,7 +531,7 @@ if (params.macs_gsize) { ext.prefix = { "${meta.id}.consensus_peaks" } publishDir = [ path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, mode: 'copy', @@ -542,7 +542,7 @@ if (params.macs_gsize) { ext.args = '-F SAF -O --fracOverlap 0.2' publishDir = [ path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, mode: 'copy', @@ -559,7 +559,7 @@ if (params.macs_gsize) { ext.prefix = 'consensus_peaks' publishDir = [ path: { [ - "${params.outdir}/bwa/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, mode: 'copy', @@ -573,7 +573,7 @@ if (params.macs_gsize) { // process { // withName: DESEQ2_FEATURECOUNTS { // publishDir = [ - // path: { "${params.outdir}/bwa/mergedLibrary/macs2" }, + // path: { "${params.outdir}/${params.aligner}/mergedLibrary/macs2" }, // mode: 'copy', // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } // ] From 3b94ec5a5b6e1933a13f97f190f7860925b33374 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 26 Jan 2022 10:37:28 +0100 Subject: [PATCH 311/538] Update changelog --- CHANGELOG.md | 5 +++++ 1 file changed, 5 insertions(+) diff --git a/CHANGELOG.md b/CHANGELOG.md index 27d0d4867..2d9aa7044 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -12,10 +12,13 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 * Bump minimum Nextflow version from `21.04.0` -> `21.10.3` * Updated pipeline template to [nf-core/tools 2.2](https://github.com/nf-core/tools/releases/tag/2.2) * Added `python3` shebang to appropriate scripts in `bin/` directory +* [[#160](https://github.com/nf-core/chipseq/issues/160)] - Add `bowtie2` and `star` as available aligners, +via the `--aligner` parameter ### Other enhancements & fixes * Update pipeline template to nf-core/tools `2.1` +* Add `--save_unaligned` parameter (only available for `bowtie2` and `star`) ### Parameters @@ -25,6 +28,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 | `--conda` | `--enable_conda` | | `--single_end` | | | | `--skip_qc` | +| | `--aligner` | +| | `--save_unaligned` | > **NB:** Parameter has been __updated__ if both old and new parameter information is present. > **NB:** Parameter has been __added__ if just the new parameter information is present. From 744a4ca69fb2da9df96e3c4e29d55427e93cb4df Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 26 Jan 2022 10:37:48 +0100 Subject: [PATCH 312/538] Add tests for aligners --- .github/workflows/ci.yml | 22 ++++++++++++++++++++++ 1 file changed, 22 insertions(+) diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 9cbd18562..b07666f23 100755 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -67,3 +67,25 @@ jobs: - name: Run pipeline with various parameters run: | nextflow run ${GITHUB_WORKSPACE} -profile test,docker ${{ matrix.parameters }} + + aligners: + name: Test available aligners + if: ${{ github.event_name != 'push' || (github.event_name == 'push' && github.repository == 'nf-core/chipseq') }} + runs-on: ubuntu-latest + strategy: + matrix: + aligner: + - "bowtie2" + - "star" + steps: + - name: Check out pipeline code + uses: actions/checkout@v2 + + - name: Install Nextflow + run: | + wget -qO- get.nextflow.io | bash + sudo mv nextflow /usr/local/bin/ + + - name: Run pipeline with the different aligners available + run: | + nextflow run ${GITHUB_WORKSPACE} -profile test,docker --aligner ${{ matrix.aligner }} From 83829b2bb5933114d33dfff09dcdcfd24213c7a5 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 31 Jan 2022 23:01:15 +0100 Subject: [PATCH 313/538] Rearrange output directories and fix errors --- conf/modules.config | 271 ++++++++++++++++++++++++++++---------------- 1 file changed, 175 insertions(+), 96 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 70d654a65..b46fa0930 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -51,8 +51,12 @@ process { enabled: params.save_reference ] } - // withName: 'UNTAR_.*' { - withName: 'UNTAR' { + + withName: 'UNTAR_.*' { + ext.args2 = '--no-same-owner' + } + + withName: 'UNTAR_.*|BWA_INDEX|BOWTIE2_BUILD|STAR_GENOMEGENERATE' { publishDir = [ path: { "${params.outdir}/genome/index" }, mode: 'copy', @@ -60,6 +64,7 @@ process { enabled: params.save_reference ] } + withName: GFFREAD { ext.args = '--keep-exon-attrs -F -T' publishDir = [ @@ -69,6 +74,7 @@ process { enabled: params.save_reference ] } + withName: GTF2BED { publishDir = [ path: { "${params.outdir}/genome" }, @@ -77,6 +83,7 @@ process { enabled: params.save_reference ] } + withName: CUSTOM_GETCHROMSIZES { publishDir = [ path: { "${params.outdir}/genome" }, @@ -85,6 +92,7 @@ process { enabled: params.save_reference ] } + withName: GENOME_BLACKLIST_REGIONS { publishDir = [ path: { "${params.outdir}/genome" }, @@ -103,6 +111,18 @@ if (!(params.skip_fastqc || params.skip_qc)) { process { withName: '.*:FASTQC_TRIMGALORE:FASTQC' { ext.args = '--quiet' + publishDir = [ + [ + path: { "${params.outdir}/fastqc" }, + mode: 'copy', + pattern: "*.{html}" + ], + [ + path: { "${params.outdir}/fastqc/zips" }, + mode: 'copy', + pattern: "*.{zip}" + ] + ] } } } @@ -118,18 +138,23 @@ if (!params.skip_trimming) { [ path: { "${params.outdir}/trimgalore/fastqc" }, mode: 'copy', - pattern: "*.{html,zip}" + pattern: "*.{html}" ], [ - path: { "${params.outdir}/trimgalore" }, + path: { "${params.outdir}/trimgalore/fastqc/zips" }, mode: 'copy', - pattern: "*.fq.gz", - enabled: params.save_trimmed + pattern: "*.{zip}" ], [ - path: { "${params.outdir}/trimgalore" }, + path: { "${params.outdir}/trimgalore/logs" }, mode: 'copy', pattern: "*.txt" + ], + [ + path: { "${params.outdir}/trimgalore" }, + mode: 'copy', + pattern: "*.fq.gz", + enabled: params.save_trimmed ] ] } @@ -140,44 +165,54 @@ process { withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/library" }, - mode: 'copy', - pattern: "*.bam", - enabled: params.save_align_intermeds + path: { "${params.outdir}/${params.aligner}/samtools" }, + // enabled: params.save_align_intermeds ] } + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { - // ext.args = params.bam_csi_index ? '-c' : '' ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/library" }, - mode: 'copy', - pattern: '*.{bai,csi}', - enabled: params.save_align_intermeds + path: { "${params.outdir}/${params.aligner}/samtools" }, + // enabled: params.save_align_intermeds ] } - withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:SAMTOOLS_STATS' { - // ext.args = params.bam_csi_index ? '-c' : '' + + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:SAMTOOLS_.*' { ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/library" }, - mode: 'copy', - pattern: "*.{stats,flagstat,idxstats}", - enabled: params.save_align_intermeds + path: { "${params.outdir}/${params.aligner}/library/samtools_stats" }, + // enabled: false ] } + + // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:SAMTOOLS_FLAGSTAT' { + // ext.prefix = { "${meta.id}.Lb.sorted" } + // publishDir = [ + // path: { "${params.outdir}/${params.aligner}/library/samtools_stats_flagstat" }, + // // enabled: false + // ] + // } + // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:SAMTOOLS_IDXSTATS' { + // ext.prefix = { "${meta.id}.Lb.sorted" } + // publishDir = [ + // path: { "${params.outdir}/${params.aligner}/samtools_idxstats" }, + // // enabled: false + // ] + // } } if (params.aligner == 'bwa') { process { - withName: BWA_INDEX { - ext.args = '-a bwtsw' - publishDir = [ - path: { "${params.outdir}/genome/${params.aligner}/index" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } + // withName: BWA_INDEX { + // ext.args = '-a bwtsw' + // publishDir = [ + // path: { "${params.outdir}/genome/index" }, + // mode: 'copy', + // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + // enable: params.save_reference + // ] + // } withName: BWA_MEM { ext.args = [ '-M', @@ -196,15 +231,15 @@ if (params.aligner == 'bwa') { if (params.aligner == 'bowtie2') { process { - withName: BOWTIE2_BUILD { - ext.args = '' - publishDir = [ - path: { "${params.outdir}/genome/${params.aligner}/index" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - withName: BOWTIE2_ALIGN { + // withName: 'BOWTIE2_BUILD' { + // ext.args = '' + // publishDir = [ + // path: { "${params.outdir}/genome/index" }, + // mode: 'copy', + // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + // ] + // } + withName: 'BOWTIE2_ALIGN' { ext.args = '' ext.prefix = { "${meta.id}.Lb" } publishDir = [ @@ -218,14 +253,14 @@ if (params.aligner == 'bowtie2') { if (params.aligner == 'star') { process { - withName: STAR_GENOMEGENERATE { - ext.args = '' - publishDir = [ - path: { "${params.outdir}/genome/${params.aligner}/index" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } + // withName: STAR_GENOMEGENERATE { + // ext.args = '' + // publishDir = [ + // path: { "${params.outdir}/genome/index" }, + // mode: 'copy', + // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + // ] + // } withName: '.*:ALIGN_STAR:STAR_ALIGN' { ext.args = [ '--runMode alignReads', @@ -244,12 +279,9 @@ if (params.aligner == 'star') { pattern: '*.{out,tab}' ], [ - path: { "${params.outdir}/${params.aligner}" }, + path: { "${params.outdir}/${params.aligner}/library" }, mode: 'copy', pattern: '*.bam', - // TODO - // enabled: params.save_align_intermeds - enabled: false ], [ path: { "${params.outdir}/${params.aligner}/unmapped" }, @@ -272,6 +304,7 @@ process { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } + withName: '.*:MARK_DUPLICATES_PICARD:PICARD_MARKDUPLICATES' { ext.args = 'ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' ext.prefix = { "${meta.id}.mLb.mkD.sorted" } @@ -288,8 +321,8 @@ process { ] ] } + withName: '.*:MARK_DUPLICATES_PICARD:SAMTOOLS_INDEX' { - // ext.args = params.bam_csi_index ? '-c' : '' // TODO implement it ext.prefix = { "${meta.id}.mkD.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, @@ -297,13 +330,15 @@ process { pattern: '*.{bai,csi}' ] } + withName: '.*:MARK_DUPLICATES_PICARD:BAM_STATS_SAMTOOLS:.*' { publishDir = [ - path: { "${params.outdir}/${params.aligner}/samtools_stats" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/samtools_stats" }, mode: 'copy', pattern: '*.{stats,flagstat,idxstats}' ] } + withName: BAM_FILTER { ext.prefix = { "${meta.id}.mLb.flT.sorted" } publishDir = [ @@ -312,6 +347,7 @@ process { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } + withName: BAM_REMOVE_ORPHANS { ext.args = '--only_fr_pairs' ext.prefix = { "${meta.id}.mLb.clN" } @@ -321,6 +357,7 @@ process { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:FILTER_BAM_BAMTOOLS:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ @@ -329,6 +366,7 @@ process { pattern: '*.{bai,csi}' ] } + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:FILTER_BAM_BAMTOOLS:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ @@ -337,14 +375,16 @@ process { pattern: "*.bam" ] } + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:FILTER_BAM_BAMTOOLS:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:.*' { ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/library" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/samtools_stats" }, mode: 'copy', pattern: "*.{stats,flagstat,idxstats}" ] } + withName: PHANTOMPEAKQUALTOOLS { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ @@ -353,26 +393,38 @@ process { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } + withName: MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { publishDir = [ path: { "${params.outdir}/multiqc" }, enabled: false ] } + withName: BEDTOOLS_GENOMECOV { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + [ + path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ], + [ + path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig/scale" }, + mode: 'copy', + pattern: "*.txt" + ] ] } + withName: UCSC_BEDGRAPHTOBIGWIG { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + [ + path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig" }, + mode: 'copy', + pattern: "*.bigWig" + ] ] } } @@ -383,9 +435,16 @@ if (!params.skip_picard_metrics) { ext.args = 'VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary/picard_metrics" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + [ + path: { "${params.outdir}/${params.aligner}/mergedLibrary/picard_metrics" }, + mode: 'copy', + pattern: "*.{alignment_summary_metrics,base_distribution_by_cycle_metrics,insert_size_metrics,quality_by_cycle_metrics,quality_distribution_metrics,txt}" + ], + [ + path: { "${params.outdir}/${params.aligner}/mergedLibrary/picard_metrics/pdf" }, + mode: 'copy', + pattern: "*.pdf" + ] ] } } @@ -407,27 +466,27 @@ if (!params.skip_preseq) { if (!params.skip_plot_profile) { process { - withName: DEEPTOOLS_COMPUTEMATRIX { + withName: 'DEEPTOOLS_COMPUTEMATRIX' { ext.args = 'scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels' ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools" }, - mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotProfile" }, ] } - withName: DEEPTOOLS_PLOTPROFILE { + + withName: 'DEEPTOOLS_PLOTPROFILE' { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotProfile" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } + withName: DEEPTOOLS_PLOTHEATMAP { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotProfile" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -444,7 +503,7 @@ if (!params.skip_plot_fingerprint) { ].join(' ').trim() ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotFingerprint" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -454,7 +513,7 @@ if (!params.skip_plot_fingerprint) { if (params.macs_gsize) { process { - withName: MACS2_CALLPEAK { + withName: 'MACS2_CALLPEAK' { ext.args = [ '--keep-dup all', params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}", @@ -471,13 +530,19 @@ if (params.macs_gsize) { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } + withName: FRIP_SCORE { ext.args = '-bed -c -f 0.20' publishDir = [ - path: { "${params.outdir}/frip" }, + path: { [ + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/qc' + ].join('') }, enable: false ] } + withName: MULTIQC_CUSTOM_PEAKS { publishDir = [ path: { "${params.outdir}/multiqc" }, @@ -492,32 +557,35 @@ if (params.macs_gsize) { ext.args = '-o ./ -p macs2_peak' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } + withName: HOMER_ANNOTATEPEAKS_MACS2 { ext.args = '-gid' // ext.prefix = 'peaks' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } + withName: PLOT_HOMER_ANNOTATEPEAKS { ext.args = '-o ./ -p macs2_annotatePeaks' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/qc' + ].join('') }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -531,20 +599,23 @@ if (params.macs_gsize) { ext.prefix = { "${meta.id}.consensus_peaks" } publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/consensus' + ].join('') }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } + withName: SUBREAD_FEATURECOUNTS { ext.args = '-F SAF -O --fracOverlap 0.2' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/consensus' + ].join('') }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -559,9 +630,10 @@ if (params.macs_gsize) { ext.prefix = 'consensus_peaks' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/consensus' + ].join('') }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -573,7 +645,11 @@ if (params.macs_gsize) { // process { // withName: DESEQ2_FEATURECOUNTS { // publishDir = [ - // path: { "${params.outdir}/${params.aligner}/mergedLibrary/macs2" }, + // path: { [ + // "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + // params.narrow_peak? '/narrowPeak' : '/broadPeak', + // '/consensus/deseq2' + // ].join('') }, // mode: 'copy', // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } // ] @@ -586,9 +662,9 @@ if (params.macs_gsize) { withName: IGV { publishDir = [ path: { [ - "${params.outdir}/igv", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + "${params.outdir}/igv", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -602,7 +678,10 @@ if (!params.skip_multiqc) { withName: MULTIQC { ext.args = params.multiqc_title ? "--title \"$params.multiqc_title\"" : '' publishDir = [ - path: { "${params.outdir}/multiqc" }, + path: { [ + "${params.outdir}/multiqc", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] From b63137de39da28a57b154a0b7966dff93f997bc4 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 31 Jan 2022 23:01:51 +0100 Subject: [PATCH 314/538] Add bowtie2 and star to citation and order citations alphabetically --- CITATIONS.md | 42 ++++++++++++++++++++++++------------------ 1 file changed, 24 insertions(+), 18 deletions(-) diff --git a/CITATIONS.md b/CITATIONS.md index 8d0bbf55b..3c62c91f3 100644 --- a/CITATIONS.md +++ b/CITATIONS.md @@ -16,44 +16,50 @@ * [BEDTools](https://www.ncbi.nlm.nih.gov/pubmed/20110278/) > Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010 Mar 15;26(6):841-2. doi: 10.1093/bioinformatics/btq033. Epub 2010 Jan 28. PubMed PMID: 20110278; PubMed Central PMCID: PMC2832824. -* [SAMtools](https://www.ncbi.nlm.nih.gov/pubmed/19505943/) - > Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R; 1000 Genome Project Data Processing Subgroup. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 2009 Aug 15;25(16):2078-9. doi: 10.1093/bioinformatics/btp352. Epub 2009 Jun 8. PubMed PMID: 19505943; PubMed Central PMCID: PMC2723002. - * [BamTools](https://www.ncbi.nlm.nih.gov/pubmed/21493652/) > Barnett DW, Garrison EK, Quinlan AR, Strömberg MP, Marth GT. BamTools: a C++ API and toolkit for analyzing and managing BAM files. Bioinformatics. 2011 Jun 15;27(12):1691-2. doi: 10.1093/bioinformatics/btr174. Epub 2011 Apr 14. PubMed PMID: 21493652; PubMed Central PMCID: PMC3106182. -* [UCSC tools](https://www.ncbi.nlm.nih.gov/pubmed/20639541/) - > Kent WJ, Zweig AS, Barber G, Hinrichs AS, Karolchik D. BigWig and BigBed: enabling browsing of large distributed datasets. Bioinformatics. 2010 Sep 1;26(17):2204-7. doi: 10.1093/bioinformatics/btq351. Epub 2010 Jul 17. PubMed PMID: 20639541; PubMed Central PMCID: PMC2922891. - -* [preseq](https://www.ncbi.nlm.nih.gov/pubmed/23435259/) - > Daley T, Smith AD. Predicting the molecular complexity of sequencing libraries. Nat Methods. 2013 Apr;10(4):325-7. doi: 10.1038/nmeth.2375. Epub 2013 Feb 24. PubMed PMID: 23435259; PubMed Central PMCID: PMC3612374. +* [Bowtie2](https:/dx.doi.org/10.1038/nmeth.1923) + > Langmead, B. and Salzberg, S. L. 2012 Fast gapped-read alignment with Bowtie 2. Nature methods, 9(4), p. 357–359. doi: 10.1038/nmeth.1923. * [deepTools](https://www.ncbi.nlm.nih.gov/pubmed/27079975/) > Ramírez F, Ryan DP, Grüning B, Bhardwaj V, Kilpert F, Richter AS, Heyne S, Dündar F, Manke T. deepTools2: a next generation web server for deep-sequencing data analysis. Nucleic Acids Res. 2016 Jul 8;44(W1):W160-5. doi: 10.1093/nar/gkw257. Epub 2016 Apr 13. PubMed PMID: 27079975; PubMed Central PMCID: PMC4987876. -* [MACS2](https://www.ncbi.nlm.nih.gov/pubmed/18798982/) - > Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W, Liu XS. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008;9(9):R137. doi: 10.1186/gb-2008-9-9-r137. Epub 2008 Sep 17. PubMed PMID: 18798982; PubMed Central PMCID: PMC2592715. +* [FastQC](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/) + +* [featureCounts](https://www.ncbi.nlm.nih.gov/pubmed/24227677/) + > Liao Y, Smyth GK, Shi W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014 Apr 1;30(7):923-30. doi: 10.1093/bioinformatics/btt656. Epub 2013 Nov 13. PubMed PMID: 24227677. * [HOMER](https://www.ncbi.nlm.nih.gov/pubmed/20513432/) > Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010 May 28;38(4):576-89. doi: 10.1016/j.molcel.2010.05.004. PubMed PMID: 20513432; PubMed Central PMCID: PMC2898526. -* [phantompeakqualtools](https://www.ncbi.nlm.nih.gov/pubmed/22955991/) - > Landt SG, Marinov GK, Kundaje A, Kheradpour P, Pauli F, Batzoglou S, Bernstein BE, Bickel P, Brown JB, Cayting P, Chen Y, DeSalvo G, Epstein C, Fisher-Aylor KI, Euskirchen G, Gerstein M, Gertz J, Hartemink AJ, Hoffman MM, Iyer VR, Jung YL, Karmakar S, Kellis M, Kharchenko PV, Li Q, Liu T, Liu XS, Ma L, Milosavljevic A, Myers RM, Park PJ, Pazin MJ, Perry MD, Raha D, Reddy TE, Rozowsky J, Shoresh N, Sidow A, Slattery M, Stamatoyannopoulos JA, Tolstorukov MY, White KP, Xi S, Farnham PJ, Lieb JD, Wold BJ, Snyder M. ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res. 2012 Sep;22(9):1813-31. doi: 10.1101/gr.136184.111. PubMed PMID: 22955991; PubMed Central PMCID: PMC3431496. - -* [featureCounts](https://www.ncbi.nlm.nih.gov/pubmed/24227677/) - > Liao Y, Smyth GK, Shi W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014 Apr 1;30(7):923-30. doi: 10.1093/bioinformatics/btt656. Epub 2013 Nov 13. PubMed PMID: 24227677. +* [MACS2](https://www.ncbi.nlm.nih.gov/pubmed/18798982/) + > Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W, Liu XS. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008;9(9):R137. doi: 10.1186/gb-2008-9-9-r137. Epub 2008 Sep 17. PubMed PMID: 18798982; PubMed Central PMCID: PMC2592715. * [MultiQC](https://pubmed.ncbi.nlm.nih.gov/27312411/) > Ewels P, Magnusson M, Lundin S, Käller M. MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics. 2016 Oct 1;32(19):3047-8. doi: 10.1093/bioinformatics/btw354. Epub 2016 Jun 16. PubMed PMID: 27312411; PubMed Central PMCID: PMC5039924. -* [FastQC](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/) - -* [Trim Galore!](https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/) +* [phantompeakqualtools](https://www.ncbi.nlm.nih.gov/pubmed/22955991/) + > Landt SG, Marinov GK, Kundaje A, Kheradpour P, Pauli F, Batzoglou S, Bernstein BE, Bickel P, Brown JB, Cayting P, Chen Y, DeSalvo G, Epstein C, Fisher-Aylor KI, Euskirchen G, Gerstein M, Gertz J, Hartemink AJ, Hoffman MM, Iyer VR, Jung YL, Karmakar S, Kellis M, Kharchenko PV, Li Q, Liu T, Liu XS, Ma L, Milosavljevic A, Myers RM, Park PJ, Pazin MJ, Perry MD, Raha D, Reddy TE, Rozowsky J, Shoresh N, Sidow A, Slattery M, Stamatoyannopoulos JA, Tolstorukov MY, White KP, Xi S, Farnham PJ, Lieb JD, Wold BJ, Snyder M. ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res. 2012 Sep;22(9):1813-31. doi: 10.1101/gr.136184.111. PubMed PMID: 22955991; PubMed Central PMCID: PMC3431496. * [picard-tools](http://broadinstitute.github.io/picard) +* [preseq](https://www.ncbi.nlm.nih.gov/pubmed/23435259/) + > Daley T, Smith AD. Predicting the molecular complexity of sequencing libraries. Nat Methods. 2013 Apr;10(4):325-7. doi: 10.1038/nmeth.2375. Epub 2013 Feb 24. PubMed PMID: 23435259; PubMed Central PMCID: PMC3612374. + * [pysam](https://github.com/pysam-developers/pysam) +* [SAMtools](https://www.ncbi.nlm.nih.gov/pubmed/19505943/) + > Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R; 1000 Genome Project Data Processing Subgroup. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 2009 Aug 15;25(16):2078-9. doi: 10.1093/bioinformatics/btp352. Epub 2009 Jun 8. PubMed PMID: 19505943; PubMed Central PMCID: PMC2723002. + +* [STAR](https://pubmed.ncbi.nlm.nih.gov/23104886/) + > Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR. STAR: ultrafast universal RNA-seq aligner Bioinformatics. 2013 Jan 1;29(1):15-21. doi: 10.1093/bioinformatics/bts635. Epub 2012 Oct 25. PubMed PMID: 23104886; PubMed Central PMCID: PMC3530905. + +* [Trim Galore!](https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/) + +* [UCSC tools](https://www.ncbi.nlm.nih.gov/pubmed/20639541/) + > Kent WJ, Zweig AS, Barber G, Hinrichs AS, Karolchik D. BigWig and BigBed: enabling browsing of large distributed datasets. Bioinformatics. 2010 Sep 1;26(17):2204-7. doi: 10.1093/bioinformatics/btq351. Epub 2010 Jul 17. PubMed PMID: 20639541; PubMed Central PMCID: PMC2922891. + ## R packages * [R](https://www.R-project.org/) From 188feef2d0a208f080f573a09b927dfb1f5df46d Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 31 Jan 2022 23:03:39 +0100 Subject: [PATCH 315/538] Fix untar calls --- subworkflows/local/prepare_genome.nf | 15 ++++++++++----- 1 file changed, 10 insertions(+), 5 deletions(-) diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index a4e1be85f..3c3df3e90 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -8,7 +8,12 @@ include { GUNZIP as GUNZIP_GFF GUNZIP as GUNZIP_GENE_BED GUNZIP as GUNZIP_BLACKLIST } from '../../modules/nf-core/modules/gunzip/main' -include { UNTAR } from '../../modules/nf-core/modules/untar/main' + +include { + UNTAR as UNTAR_BWA_INDEX + UNTAR as UNTAR_BOWTIE2_INDEX + UNTAR as UNTAR_STAR_INDEX } from '../../modules/nf-core/modules/untar/main' + include { GFFREAD } from '../../modules/nf-core/modules/gffread/main' include { CUSTOM_GETCHROMSIZES } from '../../modules/nf-core/modules/custom/getchromsizes/main' include { BWA_INDEX } from '../../modules/nf-core/modules/bwa/index/main' @@ -119,8 +124,8 @@ workflow PREPARE_GENOME { if (prepare_tool_index == 'bwa') { if (params.bwa_index) { if (params.bwa_index.endsWith('.tar.gz')) { - ch_bwa_index = UNTAR ( params.bwa_index ).untar - ch_versions = ch_versions.mix(UNTAR.out.versions) + ch_bwa_index = UNTAR_BWA_INDEX ( params.bwa_index ).untar + ch_versions = ch_versions.mix(UNTAR_BWA_INDEX.out.versions) } else { ch_bwa_index = file(params.bwa_index) } @@ -137,8 +142,8 @@ workflow PREPARE_GENOME { if (prepare_tool_index == 'bowtie2') { if (params.bowtie2_index) { if (params.bowtie2_index.endsWith('.tar.gz')) { - ch_bowtie2_index = UNTAR ( params.bowtie2_index ).untar - ch_versions = ch_versions.mix(UNTAR.out.versions) + ch_bowtie2_index = UNTAR_BOWTIE2_INDEX ( params.bowtie2_index ).untar + ch_versions = ch_versions.mix(UNTAR_BOWTIE2_INDEX.out.versions) } else { ch_bowtie2_index = file(params.bowtie2_index) } From 2076a2f5f5fa3a1d71d8c55ab8fc3591c0cd4209 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 1 Feb 2022 10:56:11 +0100 Subject: [PATCH 316/538] Clean scripts --- subworkflows/nf-core/align_star.nf | 1 - workflows/chipseq.nf | 8 ++------ 2 files changed, 2 insertions(+), 7 deletions(-) diff --git a/subworkflows/nf-core/align_star.nf b/subworkflows/nf-core/align_star.nf index 2f3527e05..474621824 100644 --- a/subworkflows/nf-core/align_star.nf +++ b/subworkflows/nf-core/align_star.nf @@ -38,7 +38,6 @@ workflow ALIGN_STAR { bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] - // csi = BAM_SORT_SAMTOOLS.out.csi // channel: [ val(meta), [ csi ] ] //TODO stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 92c0f747e..912e2ff39 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -209,10 +209,8 @@ workflow CHIPSEQ { ch_samtools_stats = ALIGN_STAR.out.stats ch_samtools_flagstat = ALIGN_STAR.out.flagstat ch_samtools_idxstats = ALIGN_STAR.out.idxstats - ch_star_multiqc = ALIGN_STAR.out.log_final // TODO for the rest of aligners - // if (params.bam_csi_index) { //TODO for the rest of aligners - // ch_genome_bam_index = ALIGN_STAR.out.csi - // } + ch_star_multiqc = ALIGN_STAR.out.log_final + ch_versions = ch_versions.mix(ALIGN_STAR.out.versions) } @@ -427,8 +425,6 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first()) - // HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}.view() - PLOT_HOMER_ANNOTATEPEAKS ( HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, ch_peak_annotation_header, From 5317628e7319686624ff83210dfc7b72b2f471f7 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 1 Feb 2022 16:19:12 +0100 Subject: [PATCH 317/538] Clean script --- workflows/chipseq.nf | 8 +++----- 1 file changed, 3 insertions(+), 5 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 912e2ff39..2bddc7689 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -210,17 +210,14 @@ workflow CHIPSEQ { ch_samtools_flagstat = ALIGN_STAR.out.flagstat ch_samtools_idxstats = ALIGN_STAR.out.idxstats ch_star_multiqc = ALIGN_STAR.out.log_final - + ch_versions = ch_versions.mix(ALIGN_STAR.out.versions) } // // SUBWORKFLOW: Merge resequenced BAM files // - // ALIGN_BWA_MEM //DEL ch_genome_bam - // .out //DEL - // .bam //DEL .map { meta, bam -> fmeta = meta.findAll { it.key != 'read_group' } @@ -238,6 +235,7 @@ workflow CHIPSEQ { // // SUBWORKFLOW: Mark duplicates & filter BAM files after merging // + ch_markduplicates_multiqc = Channel.empty() MARK_DUPLICATES_PICARD ( PICARD_MERGESAMFILES.out.bam ) @@ -580,7 +578,7 @@ workflow CHIPSEQ { ch_custompeaks_frip_multiqc.collect{it[1]}.ifEmpty([]), ch_custompeaks_count_multiqc.collect{it[1]}.ifEmpty([]), ch_plothomerannotatepeaks_multiqc.collect{it[1]}.ifEmpty([]), - ch_subreadfeaturecounts_multiqc.collect{it[1]}.ifEmpty([]), + ch_subreadfeaturecounts_multiqc.collect{it[1]}.ifEmpty([])//, // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) ) multiqc_report = MULTIQC.out.report.toList() From 99aedd3b7e5adaff830c6687e9f0568bcd7d6b40 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 1 Feb 2022 16:21:54 +0100 Subject: [PATCH 318/538] Update modules configuration --- conf/modules.config | 85 ++++++++++++++++----------------------------- 1 file changed, 30 insertions(+), 55 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index b46fa0930..b270e4f12 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -166,7 +166,8 @@ process { ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/samtools" }, - // enabled: params.save_align_intermeds + mode: 'copy' + // enabled: params.save_align_intermeds // CHECK ] } @@ -174,7 +175,9 @@ process { ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/samtools" }, - // enabled: params.save_align_intermeds + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } // CHECK + // enabled: params.save_align_intermeds // CHECK ] } @@ -182,37 +185,14 @@ process { ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/library/samtools_stats" }, - // enabled: false + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - - // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:SAMTOOLS_FLAGSTAT' { - // ext.prefix = { "${meta.id}.Lb.sorted" } - // publishDir = [ - // path: { "${params.outdir}/${params.aligner}/library/samtools_stats_flagstat" }, - // // enabled: false - // ] - // } - // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:SAMTOOLS_IDXSTATS' { - // ext.prefix = { "${meta.id}.Lb.sorted" } - // publishDir = [ - // path: { "${params.outdir}/${params.aligner}/samtools_idxstats" }, - // // enabled: false - // ] - // } } if (params.aligner == 'bwa') { process { - // withName: BWA_INDEX { - // ext.args = '-a bwtsw' - // publishDir = [ - // path: { "${params.outdir}/genome/index" }, - // mode: 'copy', - // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - // enable: params.save_reference - // ] - // } withName: BWA_MEM { ext.args = [ '-M', @@ -231,14 +211,6 @@ if (params.aligner == 'bwa') { if (params.aligner == 'bowtie2') { process { - // withName: 'BOWTIE2_BUILD' { - // ext.args = '' - // publishDir = [ - // path: { "${params.outdir}/genome/index" }, - // mode: 'copy', - // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - // ] - // } withName: 'BOWTIE2_ALIGN' { ext.args = '' ext.prefix = { "${meta.id}.Lb" } @@ -253,14 +225,6 @@ if (params.aligner == 'bowtie2') { if (params.aligner == 'star') { process { - // withName: STAR_GENOMEGENERATE { - // ext.args = '' - // publishDir = [ - // path: { "${params.outdir}/genome/index" }, - // mode: 'copy', - // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - // ] - // } withName: '.*:ALIGN_STAR:STAR_ALIGN' { ext.args = [ '--runMode alignReads', @@ -310,14 +274,15 @@ process { ext.prefix = { "${meta.id}.mLb.mkD.sorted" } publishDir = [ [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/picard_metrics" }, mode: 'copy', - pattern: '*metrics.txt' + pattern: '*.metrics.txt' ], [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: 'copy', pattern: '*.bam' + enabled: params.save_align_intermeds ] ] } @@ -345,6 +310,7 @@ process { path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + enabled: params.save_align_intermeds ] } @@ -390,14 +356,15 @@ process { publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/phantompeakqualtools" }, mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + pattern: "*.{out,pdf}" ] } withName: MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { publishDir = [ - path: { "${params.outdir}/multiqc" }, - enabled: false + path: { "${params.outdir}/${params.aligner}/mergedLibrary/phantompeakqualtools" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -407,7 +374,7 @@ process { [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig" }, mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + pattern: "*.bigWig" ], [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig/scale" }, @@ -438,7 +405,7 @@ if (!params.skip_picard_metrics) { [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/picard_metrics" }, mode: 'copy', - pattern: "*.{alignment_summary_metrics,base_distribution_by_cycle_metrics,insert_size_metrics,quality_by_cycle_metrics,quality_distribution_metrics,txt}" + pattern: "*_metrics" ], [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/picard_metrics/pdf" }, @@ -471,6 +438,8 @@ if (!params.skip_plot_profile) { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotProfile" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -539,14 +508,19 @@ if (params.macs_gsize) { params.narrow_peak? '/narrowPeak' : '/broadPeak', '/qc' ].join('') }, - enable: false + enabled: false ] } withName: MULTIQC_CUSTOM_PEAKS { publishDir = [ - path: { "${params.outdir}/multiqc" }, - enabled: false + path: { [ + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/qc' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } } @@ -558,8 +532,9 @@ if (params.macs_gsize) { publishDir = [ path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/qc' + ].join('') }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] From 7110276838923a52646031f27058d983220e0a81 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 1 Feb 2022 16:22:29 +0100 Subject: [PATCH 319/538] Update output for indexes (bowtie2 and star added) --- docs/output.md | 6 +++++- 1 file changed, 5 insertions(+), 1 deletion(-) diff --git a/docs/output.md b/docs/output.md index 6b53cd0af..d36e879df 100644 --- a/docs/output.md +++ b/docs/output.md @@ -300,7 +300,11 @@ Once installed, open IGV, go to `File > Open Session` and select the `igv_sessio * `genome/` * A number of genome-specific files are generated by the pipeline in order to aid in the filtering of the data, and because they are required by standard tools such as BEDTools. These can be found in this directory along with the genome fasta file which is required by IGV. If using a genome from AWS iGenomes and if it exists a `README.txt` file containing information about the annotation version will also be saved in this directory. -* `genome/BWAIndex/` +* `genome/index/` + * `bwa/`: Directory containing BWA indices. + * `bowtie2/`: Directory containing BOWTIE2 indices. + * `star/`: Directory containing STAR indices. + * If the `--save_reference` parameter is provided then the alignment indices generated by the pipeline will be saved in this directory. This can be quite a time-consuming process so it permits their reuse for future runs of the pipeline or for other purposes. From a5d0ad65e7ee7156f9de3dbda54d12bd856a491c Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 1 Feb 2022 16:33:24 +0100 Subject: [PATCH 320/538] Fix tyops in modules.config --- conf/modules.config | 6 ++---- 1 file changed, 2 insertions(+), 4 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index b270e4f12..06d3ceb8d 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -167,7 +167,6 @@ process { publishDir = [ path: { "${params.outdir}/${params.aligner}/samtools" }, mode: 'copy' - // enabled: params.save_align_intermeds // CHECK ] } @@ -177,7 +176,6 @@ process { path: { "${params.outdir}/${params.aligner}/samtools" }, mode: 'copy', saveAs: { filename -> filename.equals('versions.yml') ? null : filename } // CHECK - // enabled: params.save_align_intermeds // CHECK ] } @@ -281,7 +279,7 @@ process { [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: 'copy', - pattern: '*.bam' + pattern: '*.bam', enabled: params.save_align_intermeds ] ] @@ -309,7 +307,7 @@ process { publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, enabled: params.save_align_intermeds ] } From ebb30c78abe42b7ab8022ab75150fa85068700d4 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 1 Feb 2022 16:34:11 +0100 Subject: [PATCH 321/538] Change outputs description (macs to macs2) --- docs/output.md | 12 ++++++------ 1 file changed, 6 insertions(+), 6 deletions(-) diff --git a/docs/output.md b/docs/output.md index d36e879df..e633ce4b8 100644 --- a/docs/output.md +++ b/docs/output.md @@ -157,10 +157,10 @@ The results from deepTools plotProfile gives you a quick visualisation for the g

Output files -* `bwa/mergedLibrary/macs//` +* `bwa/mergedLibrary/macs2//` * `*.xls`, `*.broadPeak` or `*.narrowPeak`, `*.gappedPeak`, `*summits.bed`: MACS2 output files - the files generated will depend on whether MACS2 has been run in *narrowPeak* or *broadPeak* mode. * `*.annotatePeaks.txt`: HOMER peak-to-gene annotation file. -* `bwa/mergedLibrary/macs//qc/` +* `bwa/mergedLibrary/macs2//qc/` * `macs_peak.plots.pdf`: QC plots for MACS2 peaks. * `macs_annotatePeaks.plots.pdf`: QC plots for peak-to-gene feature annotation. * `*.FRiP_mqc.tsv`, `*.count_mqc.tsv`, `macs_annotatePeaks.summary_mqc.tsv`: MultiQC custom-content files for FRiP score, peak count and peak-to-gene ratios. @@ -186,7 +186,7 @@ Various QC plots per sample including number of peaks, fold-change distribution,
Output files -* `bwa/mergedLibrary/macs//consensus/` +* `bwa/mergedLibrary/macs2//consensus/` * `*.bed`: Consensus peak-set across all samples in BED format. * `*.saf`: Consensus peak-set across all samples in SAF format. Required by featureCounts for read quantification. * `*.featureCounts.txt`: Read counts across all samples relative to consensus peak-set. @@ -214,18 +214,18 @@ The [featureCounts](http://bioinf.wehi.edu.au/featureCounts/) tool is used to co
Output files -* `bwa/mergedLibrary/macs//consensus//deseq2/` +* `bwa/mergedLibrary/macs2//consensus//deseq2/` * `*.results.txt`: Spreadsheet containing differential binding results across all consensus peaks and all comparisons. * `*.plots.pdf`: File containing PCA and hierarchical clustering plots. * `*.log`: Log file with information for number of differentially bound intervals at different FDR and fold-change thresholds for each comparison. * `*.dds.rld.RData`: File containing R `dds` and `rld` objects generated by DESeq2. * `R_sessionInfo.log`: File containing information about R, the OS and attached or loaded packages. - * `bwa/mergedLibrary/macs//consensus///` + * `bwa/mergedLibrary/macs2//consensus///` * `*.results.txt`: Spreadsheet containing comparison-specific DESeq2 output for differential binding results across all peaks. * `*FDR0.01.results.txt`, `*FDR0.05.results.txt`: Subset of above file for peaks that pass FDR <= 0.01 and FDR <= 0.05. * `*FDR0.01.results.bed`, `*FDR0.05.results.bed`: BED files for peaks that pass FDR <= 0.01 and FDR <= 0.05. * `*deseq2.plots.pdf`: MA, Volcano, clustering and scatterplots at FDR <= 0.01 and FDR <= 0.05. - * `bwa/mergedLibrary/macs//consensus//sizeFactors/` + * `bwa/mergedLibrary/macs2//consensus//sizeFactors/` * `*.txt`, `*.RData`: Files containing DESeq2 sizeFactors per sample.
From 240db7ddfbdeb4350234be8e2854f04be55b1e8e Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 2 Feb 2022 14:55:11 +0100 Subject: [PATCH 322/538] Add quotes to withName selectors in modules config --- conf/modules.config | 54 ++++++++++++++++++++++----------------------- 1 file changed, 27 insertions(+), 27 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 06d3ceb8d..9b4e17b44 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -65,7 +65,7 @@ process { ] } - withName: GFFREAD { + withName: 'GFFREAD' { ext.args = '--keep-exon-attrs -F -T' publishDir = [ path: { "${params.outdir}/genome" }, @@ -75,7 +75,7 @@ process { ] } - withName: GTF2BED { + withName: 'GTF2BED' { publishDir = [ path: { "${params.outdir}/genome" }, mode: 'copy', @@ -84,7 +84,7 @@ process { ] } - withName: CUSTOM_GETCHROMSIZES { + withName: 'CUSTOM_GETCHROMSIZES' { publishDir = [ path: { "${params.outdir}/genome" }, mode: 'copy', @@ -93,7 +93,7 @@ process { ] } - withName: GENOME_BLACKLIST_REGIONS { + withName: 'GENOME_BLACKLIST_REGIONS' { publishDir = [ path: { "${params.outdir}/genome" }, mode: 'copy', @@ -175,7 +175,7 @@ process { publishDir = [ path: { "${params.outdir}/${params.aligner}/samtools" }, mode: 'copy', - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } // CHECK + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -191,7 +191,7 @@ process { if (params.aligner == 'bwa') { process { - withName: BWA_MEM { + withName: 'BWA_MEM' { ext.args = [ '-M', params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' @@ -257,7 +257,7 @@ if (params.aligner == 'star') { } process { - withName: PICARD_MERGESAMFILES { + withName: 'PICARD_MERGESAMFILES' { ext.args = 'SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' ext.prefix = { "${meta.id}.mLb.sorted" } publishDir = [ @@ -302,7 +302,7 @@ process { ] } - withName: BAM_FILTER { + withName: 'BAM_FILTER' { ext.prefix = { "${meta.id}.mLb.flT.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, @@ -312,7 +312,7 @@ process { ] } - withName: BAM_REMOVE_ORPHANS { + withName: 'BAM_REMOVE_ORPHANS' { ext.args = '--only_fr_pairs' ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ @@ -349,7 +349,7 @@ process { ] } - withName: PHANTOMPEAKQUALTOOLS { + withName: 'PHANTOMPEAKQUALTOOLS' { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/phantompeakqualtools" }, @@ -358,7 +358,7 @@ process { ] } - withName: MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { + withName: 'MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS' { publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/phantompeakqualtools" }, mode: 'copy', @@ -366,7 +366,7 @@ process { ] } - withName: BEDTOOLS_GENOMECOV { + withName: 'BEDTOOLS_GENOMECOV' { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ [ @@ -382,7 +382,7 @@ process { ] } - withName: UCSC_BEDGRAPHTOBIGWIG { + withName: 'UCSC_BEDGRAPHTOBIGWIG' { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ [ @@ -396,7 +396,7 @@ process { if (!params.skip_picard_metrics) { process { - withName: PICARD_COLLECTMULTIPLEMETRICS { + withName: 'PICARD_COLLECTMULTIPLEMETRICS' { ext.args = 'VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ @@ -417,7 +417,7 @@ if (!params.skip_picard_metrics) { if (!params.skip_preseq) { process { - withName: PRESEQ_LCEXTRAP { + withName: 'PRESEQ_LCEXTRAP' { ext.args = '-verbose -bam -seed 1' ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ @@ -450,7 +450,7 @@ if (!params.skip_plot_profile) { ] } - withName: DEEPTOOLS_PLOTHEATMAP { + withName: 'DEEPTOOLS_PLOTHEATMAP' { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotProfile" }, @@ -463,7 +463,7 @@ if (!params.skip_plot_profile) { if (!params.skip_plot_fingerprint) { process { - withName: DEEPTOOLS_PLOTFINGERPRINT { + withName: 'DEEPTOOLS_PLOTFINGERPRINT' { ext.args = [ '--skipZeros', "--numberOfSamples $params.fingerprint_bins" @@ -498,7 +498,7 @@ if (params.macs_gsize) { ] } - withName: FRIP_SCORE { + withName: 'FRIP_SCORE' { ext.args = '-bed -c -f 0.20' publishDir = [ path: { [ @@ -510,7 +510,7 @@ if (params.macs_gsize) { ] } - withName: MULTIQC_CUSTOM_PEAKS { + withName: 'MULTIQC_CUSTOM_PEAKS' { publishDir = [ path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", @@ -525,7 +525,7 @@ if (params.macs_gsize) { if (!params.skip_peak_annotation && !params.skip_peak_qc) { process { - withName: PLOT_MACS2_QC { + withName: 'PLOT_MACS2_QC' { ext.args = '-o ./ -p macs2_peak' publishDir = [ path: { [ @@ -538,7 +538,7 @@ if (params.macs_gsize) { ] } - withName: HOMER_ANNOTATEPEAKS_MACS2 { + withName: 'HOMER_ANNOTATEPEAKS_MACS2' { ext.args = '-gid' // ext.prefix = 'peaks' publishDir = [ @@ -551,7 +551,7 @@ if (params.macs_gsize) { ] } - withName: PLOT_HOMER_ANNOTATEPEAKS { + withName: 'PLOT_HOMER_ANNOTATEPEAKS' { ext.args = '-o ./ -p macs2_annotatePeaks' publishDir = [ path: { [ @@ -568,7 +568,7 @@ if (params.macs_gsize) { if (!params.skip_consensus_peaks) { process { - withName: MACS2_CONSENSUS { + withName: 'MACS2_CONSENSUS' { ext.prefix = { "${meta.id}.consensus_peaks" } publishDir = [ path: { [ @@ -581,7 +581,7 @@ if (params.macs_gsize) { ] } - withName: SUBREAD_FEATURECOUNTS { + withName: 'SUBREAD_FEATURECOUNTS' { ext.args = '-F SAF -O --fracOverlap 0.2' publishDir = [ path: { [ @@ -598,7 +598,7 @@ if (params.macs_gsize) { if (!params.skip_peak_annotation) { process { - withName: HOMER_ANNOTATEPEAKS_CONSENSUS { + withName: 'HOMER_ANNOTATEPEAKS_CONSENSUS' { ext.args = '-gid' ext.prefix = 'consensus_peaks' publishDir = [ @@ -632,7 +632,7 @@ if (params.macs_gsize) { if (!params.skip_igv) { process { - withName: IGV { + withName: 'IGV' { publishDir = [ path: { [ "${params.outdir}/igv", @@ -648,7 +648,7 @@ if (params.macs_gsize) { if (!params.skip_multiqc) { process { - withName: MULTIQC { + withName: 'MULTIQC' { ext.args = params.multiqc_title ? "--title \"$params.multiqc_title\"" : '' publishDir = [ path: { [ From f69b7fdf0ae181b19f94297522458bd7678ebf49 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 2 Feb 2022 16:16:22 +0100 Subject: [PATCH 323/538] Add DESEQ2_QC back (before CONSENSUS_PEAKS_DESEQ2) --- conf/modules.config | 36 +++++++++------- modules/local/deseq2_featurecounts.nf | 60 --------------------------- modules/local/deseq2_qc.nf | 57 +++++++++++++++++++++++++ workflows/chipseq.nf | 35 +++++++++------- 4 files changed, 98 insertions(+), 90 deletions(-) delete mode 100644 modules/local/deseq2_featurecounts.nf create mode 100644 modules/local/deseq2_qc.nf diff --git a/conf/modules.config b/conf/modules.config index 9b4e17b44..154b11c4a 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -614,21 +614,27 @@ if (params.macs_gsize) { } } - // if (!params.skip_diff_analysis) { - // process { - // withName: DESEQ2_FEATURECOUNTS { - // publishDir = [ - // path: { [ - // "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - // params.narrow_peak? '/narrowPeak' : '/broadPeak', - // '/consensus/deseq2' - // ].join('') }, - // mode: 'copy', - // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - // ] - // } - // } - // } + if (!params.skip_diff_analysis) { + process { + withName: DESEQ2_QC { + ext.args = [ + '--id_col 1', + '--sample_suffix \'.mLb.clN.sorted.bam\'', + '--count_col 7', + params.deseq2_vst ? '--vst TRUE' : '' + ].join(' ').trim() + publishDir = [ + path: { [ + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/consensus/deseq2' + ].join('') }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + } + } if (!params.skip_igv) { process { diff --git a/modules/local/deseq2_featurecounts.nf b/modules/local/deseq2_featurecounts.nf deleted file mode 100644 index 120e12ce7..000000000 --- a/modules/local/deseq2_featurecounts.nf +++ /dev/null @@ -1,60 +0,0 @@ -conda (params.enable_conda ? "${baseDir}/environment.yml" : null) - -process CONSENSUS_PEAKS_DESEQ2 { - script: - echo "Avoid nf-core lint to crash for process name being commented" -} - -// /* -// * STEP 7.4: Differential analysis with DESeq2 -// */ -// process CONSENSUS_PEAKS_DESEQ2 { -// tag "${antibody}" -// label 'process_medium' -// publishDir "${params.outdir}/bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2", mode: params.publish_dir_mode, -// saveAs: { filename -> -// if (filename.endsWith('.igv.txt')) null -// else filename -// } -// -// when: -// params.macs_gsize && replicatesExist && multipleGroups && !params.skip_consensus_peaks && !params.skip_diff_analysis -// -// input: -// tuple val(antibody), val(replicatesExist), val(multipleGroups), path(counts) from ch_macs_consensus_counts -// path deseq2_pca_header from ch_deseq2_pca_header -// path deseq2_clustering_header from ch_deseq2_clustering_header -// -// output: -// path '*.tsv' into ch_macs_consensus_deseq_mqc -// path '*igv.txt' into ch_macs_consensus_deseq_comp_igv -// path '*.{RData,results.txt,pdf,log}' -// path 'sizeFactors' -// path '*vs*/*.{pdf,txt}' -// path '*vs*/*.bed' -// -// script: -// prefix = "${antibody}.consensus_peaks" -// bam_ext = params.single_end ? '.mLb.clN.sorted.bam' : '.mLb.clN.bam' -// vst = params.deseq2_vst ? '--vst TRUE' : '' -// """ -// featurecounts_deseq2.r \\ -// --featurecount_file $counts \\ -// --bam_suffix '$bam_ext' \\ -// --outdir ./ \\ -// --outprefix $prefix \\ -// --outsuffix '' \\ -// --cores $task.cpus \\ -// $vst -// -// sed 's/deseq2_pca/deseq2_pca_${task.index}/g' <$deseq2_pca_header >tmp.txt -// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt -// cat tmp.txt ${prefix}.pca.vals.txt > ${prefix}.pca.vals_mqc.tsv -// -// sed 's/deseq2_clustering/deseq2_clustering_${task.index}/g' <$deseq2_clustering_header >tmp.txt -// sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt -// cat tmp.txt ${prefix}.sample.dists.txt > ${prefix}.sample.dists_mqc.tsv -// -// find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt -// """ -// } diff --git a/modules/local/deseq2_qc.nf b/modules/local/deseq2_qc.nf new file mode 100644 index 000000000..dcc933c4f --- /dev/null +++ b/modules/local/deseq2_qc.nf @@ -0,0 +1,57 @@ +process DESEQ2_QC { + tag "$meta.id" + label 'process_medium' + + conda (params.enable_conda ? "conda-forge::r-base=4.0 bioconda::bioconductor-deseq2=1.28.0 bioconda::bioconductor-biocparallel bioconda::bioconductor-tximport bioconda::bioconductor-complexheatmap conda-forge::r-optparse conda-forge::r-ggplot2 conda-forge::r-rcolorbrewer conda-forge::r-pheatmap" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/mulled-v2-8849acf39a43cdd6c839a369a74c0adc823e2f91:ab110436faf952a33575c64dd74615a84011450b-0' : + 'quay.io/biocontainers/mulled-v2-8849acf39a43cdd6c839a369a74c0adc823e2f91:ab110436faf952a33575c64dd74615a84011450b-0' }" + + input: + tuple val(meta), path(counts) + path deseq2_pca_header + path deseq2_clustering_header + + output: + path "*.pdf" , optional:true, emit: pdf + path "*.RData" , optional:true, emit: rdata + path "*pca.vals.txt" , optional:true, emit: pca_txt + path "*pca.vals_mqc.tsv" , optional:true, emit: pca_multiqc + path "*sample.dists.txt" , optional:true, emit: dists_txt + path "*sample.dists_mqc.tsv", optional:true, emit: dists_multiqc + path "*.log" , optional:true, emit: log + path "size_factors" , optional:true, emit: size_factors + path "versions.yml" , emit: versions + + script: + if (meta.multiple_groups || meta.replicates_exist) { + def args = task.ext.args ?: '' + def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' + def antibody = meta.antibody + def prefix = "${antibody}.consensus_peaks" + """ + deseq2_qc.r \\ + --count_file $counts \\ + --outdir ./ \\ + --outprefix $prefix \\ + --cores $task.cpus \\ + $args + + sed 's/deseq2_pca/deseq2_pca_${task.index}/g' <$deseq2_pca_header >tmp.txt + sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt + cat tmp.txt ${prefix}.pca.vals.txt > ${prefix}.pca.vals_mqc.tsv + + sed 's/deseq2_clustering/deseq2_clustering_${task.index}/g' <$deseq2_clustering_header >tmp.txt + sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt + cat tmp.txt ${prefix}.sample.dists.txt > ${prefix}.sample.dists_mqc.tsv + + find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${peak_type}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + r-base: \$(echo \$(R --version 2>&1) | sed 's/^.*R version //; s/ .*\$//') + bioconductor-deseq2: \$(Rscript -e "library(DESeq2); cat(as.character(packageVersion('DESeq2')))") + END_VERSIONS + """ + } +} diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 2bddc7689..d2eabec25 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -71,8 +71,8 @@ include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_ include { FRIP_SCORE } from '../modules/local/frip_score' include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' -include { MACS2_CONSENSUS } from '../modules/local//macs2_consensus' -//include { DESEQ2_QC } from '../modules/local/deseq2_qc' +include { MACS2_CONSENSUS } from '../modules/local/macs2_consensus' +include { DESEQ2_QC } from '../modules/local/deseq2_qc' include { IGV } from '../modules/local/igv' include { MULTIQC } from '../modules/local/multiqc' include { MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS } from '../modules/local/multiqc_custom_phantompeakqualtools' @@ -81,8 +81,8 @@ include { MULTIQC_CUSTOM_PEAKS } from '../modules/local/multiqc_c // // SUBWORKFLOW: Consisting of a mix of local and nf-core/modules // -include { INPUT_CHECK } from '../subworkflows/local/input_check' -include { PREPARE_GENOME } from '../subworkflows/local/prepare_genome' +include { INPUT_CHECK } from '../subworkflows/local/input_check' +include { PREPARE_GENOME } from '../subworkflows/local/prepare_genome' include { FILTER_BAM_BAMTOOLS } from '../subworkflows/local/filter_bam_bamtools' /* @@ -484,13 +484,16 @@ workflow CHIPSEQ { ch_ip_control_bam .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } - .combine(ch_ip_saf) + .groupTuple() + .map { it -> [ it[0], it[1][0], it[2].flatten().sort() ] } + .join(ch_ip_saf) .map { it -> fmeta = it[1] - fmeta['replicates_exist'] = it[4]['replicates_exist'] - fmeta['multiple_groups'] = it[4]['multiple_groups'] - [ fmeta, it[2], it[5] ] } + fmeta['id'] = it[3]['id'] + fmeta['replicates_exist'] = it[3]['replicates_exist'] + fmeta['multiple_groups'] = it[3]['multiple_groups'] + [ fmeta, it[2], it[4] ] } .set { ch_ip_bam } SUBREAD_FEATURECOUNTS ( @@ -499,13 +502,15 @@ workflow CHIPSEQ { ch_subreadfeaturecounts_multiqc = SUBREAD_FEATURECOUNTS.out.summary ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first()) - // if (!params.skip_diff_analysis) { - // // DESEQ2_FEATURECOUNTS ( - // // params.modules['deseq2_featurecounts'] - // // ) - // // ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) - // // ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) - // } + ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) + ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) + if (!params.skip_diff_analysis) { + DESEQ2_QC ( + SUBREAD_FEATURECOUNTS.out.counts, + ch_deseq2_pca_header, + ch_deseq2_clustering_header + ) + } // // Create IGV session From 650c0b2efa1f803f5bab661fa43f573221109719 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 2 Feb 2022 16:17:12 +0100 Subject: [PATCH 324/538] Fix problems with points in sample names --- bin/deseq2_qc.r | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/bin/deseq2_qc.r b/bin/deseq2_qc.r index edb487143..e8c2617f5 100755 --- a/bin/deseq2_qc.r +++ b/bin/deseq2_qc.r @@ -53,7 +53,7 @@ if (is.null(opt$count_file)){ ################################################ ################################################ -count.table <- read.delim(file=opt$count_file,header=TRUE, row.names=NULL) +count.table <- read.delim(file=opt$count_file,header=TRUE, row.names=NULL, skip=1, check.names=FALSE) rownames(count.table) <- count.table[,opt$id_col] count.table <- count.table[,opt$count_col:ncol(count.table),drop=FALSE] colnames(count.table) <- gsub(opt$sample_suffix,"",colnames(count.table)) From 0435144fc0dfa8ff9e276c581249abeabc252c20 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 2 Feb 2022 22:40:04 +0100 Subject: [PATCH 325/538] Change param skip_diff_analysis by skip_deseq2_qc --- CHANGELOG.md | 1 + conf/modules.config | 2 +- nextflow.config | 4 ++-- nextflow_schema.json | 10 +++++----- workflows/chipseq.nf | 2 +- 5 files changed, 10 insertions(+), 9 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 2d9aa7044..18ad17afe 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -30,6 +30,7 @@ via the `--aligner` parameter | | `--skip_qc` | | | `--aligner` | | | `--save_unaligned` | +| `--skip_diff_analysis` | `--skip_deseq2_qc` | > **NB:** Parameter has been __updated__ if both old and new parameter information is present. > **NB:** Parameter has been __added__ if just the new parameter information is present. diff --git a/conf/modules.config b/conf/modules.config index 154b11c4a..b1f091632 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -614,7 +614,7 @@ if (params.macs_gsize) { } } - if (!params.skip_diff_analysis) { + if (!params.skip_deseq2_qc) { process { withName: DESEQ2_QC { ext.args = [ diff --git a/nextflow.config b/nextflow.config index d5683b804..a26796469 100644 --- a/nextflow.config +++ b/nextflow.config @@ -49,9 +49,9 @@ params { skip_peak_annotation = false skip_consensus_peaks = false - // Options: Differential analysis + // Options: DESeq2 QC deseq2_vst = false - skip_diff_analysis = false + skip_deseq2_qc = false // Options: QC skip_qc = false diff --git a/nextflow_schema.json b/nextflow_schema.json index b3d1750fb..44adb97dd 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -318,7 +318,7 @@ } } }, - "differential_analysis_options": { + "deseq_qc_options": { "title": "Differential analysis options", "type": "object", "fa_icon": "fas fa-not-equal", @@ -330,10 +330,10 @@ "help_text": "See [DESeq2 docs](http://bioconductor.org/packages/devel/bioc/vignettes/DESeq2/inst/doc/DESeq2.html#data-transformations-and-visualization).", "fa_icon": "fas fa-dolly" }, - "skip_diff_analysis": { + "skip_deseq2_qc": { "type": "boolean", - "description": "Skip differential accessibility analysis.", - "fa_icon": "fas fa-fast-forward" + "fa_icon": "fas fa-fast-forward", + "description": "Skip DESeq2 PCA and heatmap plotting." } } }, @@ -574,7 +574,7 @@ "$ref": "#/definitions/peak_calling_options" }, { - "$ref": "#/definitions/differential_analysis_options" + "$ref": "#/definitions/deseq_qc_options" }, { "$ref": "#/definitions/process_skipping_options" diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index d2eabec25..3de89848c 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -504,7 +504,7 @@ workflow CHIPSEQ { ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) - if (!params.skip_diff_analysis) { + if (!params.skip_deseq2_qc) { DESEQ2_QC ( SUBREAD_FEATURECOUNTS.out.counts, ch_deseq2_pca_header, From 1017d46edd3ee684f1be04e7482843a568d8192f Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 4 Feb 2022 10:30:22 +0100 Subject: [PATCH 326/538] Update path of BWAIndex to fetch all the files --- conf/igenomes.config | 76 ++++++++++++++++++++++---------------------- 1 file changed, 38 insertions(+), 38 deletions(-) diff --git a/conf/igenomes.config b/conf/igenomes.config index 855948def..f0b8e1676 100644 --- a/conf/igenomes.config +++ b/conf/igenomes.config @@ -13,7 +13,7 @@ params { genomes { 'GRCh37' { fasta = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BismarkIndex/" @@ -26,7 +26,7 @@ params { } 'GRCh38' { fasta = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BismarkIndex/" @@ -38,7 +38,7 @@ params { } 'GRCm38' { fasta = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BismarkIndex/" @@ -51,7 +51,7 @@ params { } 'TAIR10' { fasta = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BismarkIndex/" @@ -62,7 +62,7 @@ params { } 'EB2' { fasta = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BismarkIndex/" @@ -72,7 +72,7 @@ params { } 'UMD3.1' { fasta = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BismarkIndex/" @@ -83,7 +83,7 @@ params { } 'WBcel235' { fasta = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BismarkIndex/" @@ -94,7 +94,7 @@ params { } 'CanFam3.1' { fasta = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BismarkIndex/" @@ -105,7 +105,7 @@ params { } 'GRCz10' { fasta = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BismarkIndex/" @@ -115,7 +115,7 @@ params { } 'BDGP6' { fasta = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BismarkIndex/" @@ -126,7 +126,7 @@ params { } 'EquCab2' { fasta = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BismarkIndex/" @@ -137,7 +137,7 @@ params { } 'EB1' { fasta = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BismarkIndex/" @@ -147,7 +147,7 @@ params { } 'Galgal4' { fasta = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BismarkIndex/" @@ -157,7 +157,7 @@ params { } 'Gm01' { fasta = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BismarkIndex/" @@ -167,7 +167,7 @@ params { } 'Mmul_1' { fasta = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BismarkIndex/" @@ -178,7 +178,7 @@ params { } 'IRGSP-1.0' { fasta = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BismarkIndex/" @@ -188,7 +188,7 @@ params { } 'CHIMP2.1.4' { fasta = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BismarkIndex/" @@ -199,7 +199,7 @@ params { } 'Rnor_5.0' { fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/BismarkIndex/" @@ -209,7 +209,7 @@ params { } 'Rnor_6.0' { fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BismarkIndex/" @@ -219,7 +219,7 @@ params { } 'R64-1-1' { fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BismarkIndex/" @@ -230,7 +230,7 @@ params { } 'EF2' { fasta = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BismarkIndex/" @@ -242,7 +242,7 @@ params { } 'Sbi1' { fasta = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BismarkIndex/" @@ -252,7 +252,7 @@ params { } 'Sscrofa10.2' { fasta = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BismarkIndex/" @@ -263,7 +263,7 @@ params { } 'AGPv3' { fasta = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BismarkIndex/" @@ -273,7 +273,7 @@ params { } 'hg38' { fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BismarkIndex/" @@ -285,7 +285,7 @@ params { } 'hg19' { fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BismarkIndex/" @@ -298,7 +298,7 @@ params { } 'mm10' { fasta = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BismarkIndex/" @@ -311,7 +311,7 @@ params { } 'bosTau8' { fasta = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BismarkIndex/" @@ -321,7 +321,7 @@ params { } 'ce10' { fasta = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BismarkIndex/" @@ -333,7 +333,7 @@ params { } 'canFam3' { fasta = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BismarkIndex/" @@ -344,7 +344,7 @@ params { } 'danRer10' { fasta = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BismarkIndex/" @@ -355,7 +355,7 @@ params { } 'dm6' { fasta = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BismarkIndex/" @@ -366,7 +366,7 @@ params { } 'equCab2' { fasta = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BismarkIndex/" @@ -377,7 +377,7 @@ params { } 'galGal4' { fasta = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BismarkIndex/" @@ -388,7 +388,7 @@ params { } 'panTro4' { fasta = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BismarkIndex/" @@ -399,7 +399,7 @@ params { } 'rn6' { fasta = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BismarkIndex/" @@ -409,7 +409,7 @@ params { } 'sacCer3' { fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BismarkIndex/" @@ -419,7 +419,7 @@ params { } 'susScr3' { fasta = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BismarkIndex/" From 99fbf2e3e5248d1ed82a4cb996df9362289c6153 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 4 Feb 2022 11:17:58 +0100 Subject: [PATCH 327/538] Update changelog --- CHANGELOG.md | 1 + 1 file changed, 1 insertion(+) diff --git a/CHANGELOG.md b/CHANGELOG.md index 18ad17afe..b42ead40f 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -19,6 +19,7 @@ via the `--aligner` parameter * Update pipeline template to nf-core/tools `2.1` * Add `--save_unaligned` parameter (only available for `bowtie2` and `star`) +* Update `igenomes.config` to fetch whole `BWAIndex/version0.6.0/` folder ### Parameters From 7c446821c4a170b5b432ff3b3c3e7dd72f9837c1 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Wed, 2 Mar 2022 17:20:27 +0100 Subject: [PATCH 328/538] Update blacklist files --- .../blacklists/{ => old}/GRCm38-blacklist.bed | 0 .../blacklists/{ => old}/hg38-blacklist.bed | 0 .../blacklists/{ => old}/mm10-blacklist.bed | 0 .../{ => v1.0}/GRCh37-blacklist.bed | 0 .../hg19-blacklist.v1.bed} | 0 assets/blacklists/v2.0/ce10-blacklist.v2.bed | 100 + assets/blacklists/v2.0/ce11-blacklist.v2.bed | 97 + assets/blacklists/v2.0/dm3-blacklist.v2.bed | 271 ++ assets/blacklists/v2.0/dm6-blacklist.v2.bed | 182 + assets/blacklists/v2.0/hg19-blacklist.v2.bed | 834 ++++ assets/blacklists/v2.0/hg38-blacklist.v2.bed | 636 +++ assets/blacklists/v2.0/mm10-blacklist.v2.bed | 3435 +++++++++++++++++ assets/blacklists/v3.0/hg38-blacklist.v3.bed | 910 +++++ 13 files changed, 6465 insertions(+) rename assets/blacklists/{ => old}/GRCm38-blacklist.bed (100%) rename assets/blacklists/{ => old}/hg38-blacklist.bed (100%) rename assets/blacklists/{ => old}/mm10-blacklist.bed (100%) rename assets/blacklists/{ => v1.0}/GRCh37-blacklist.bed (100%) mode change 100755 => 100644 rename assets/blacklists/{hg19-blacklist.bed => v1.0/hg19-blacklist.v1.bed} (100%) mode change 100755 => 100644 create mode 100644 assets/blacklists/v2.0/ce10-blacklist.v2.bed create mode 100644 assets/blacklists/v2.0/ce11-blacklist.v2.bed create mode 100644 assets/blacklists/v2.0/dm3-blacklist.v2.bed create mode 100644 assets/blacklists/v2.0/dm6-blacklist.v2.bed create mode 100644 assets/blacklists/v2.0/hg19-blacklist.v2.bed create mode 100644 assets/blacklists/v2.0/hg38-blacklist.v2.bed create mode 100644 assets/blacklists/v2.0/mm10-blacklist.v2.bed create mode 100644 assets/blacklists/v3.0/hg38-blacklist.v3.bed diff --git a/assets/blacklists/GRCm38-blacklist.bed b/assets/blacklists/old/GRCm38-blacklist.bed similarity index 100% rename from assets/blacklists/GRCm38-blacklist.bed rename to assets/blacklists/old/GRCm38-blacklist.bed diff --git a/assets/blacklists/hg38-blacklist.bed b/assets/blacklists/old/hg38-blacklist.bed similarity index 100% rename from assets/blacklists/hg38-blacklist.bed rename to assets/blacklists/old/hg38-blacklist.bed diff --git a/assets/blacklists/mm10-blacklist.bed b/assets/blacklists/old/mm10-blacklist.bed similarity index 100% rename from assets/blacklists/mm10-blacklist.bed rename to assets/blacklists/old/mm10-blacklist.bed diff --git a/assets/blacklists/GRCh37-blacklist.bed b/assets/blacklists/v1.0/GRCh37-blacklist.bed old mode 100755 new mode 100644 similarity index 100% rename from assets/blacklists/GRCh37-blacklist.bed rename to assets/blacklists/v1.0/GRCh37-blacklist.bed diff --git a/assets/blacklists/hg19-blacklist.bed b/assets/blacklists/v1.0/hg19-blacklist.v1.bed old mode 100755 new mode 100644 similarity index 100% rename from assets/blacklists/hg19-blacklist.bed rename to assets/blacklists/v1.0/hg19-blacklist.v1.bed diff --git a/assets/blacklists/v2.0/ce10-blacklist.v2.bed b/assets/blacklists/v2.0/ce10-blacklist.v2.bed new file mode 100644 index 000000000..99566cec9 --- /dev/null +++ b/assets/blacklists/v2.0/ce10-blacklist.v2.bed @@ -0,0 +1,100 @@ +chrIII 449300 453600 High Signal Region +chrIII 930200 932600 High Signal Region +chrIII 1016500 1021400 Low Mappability +chrIII 1293500 1303900 High Signal Region +chrIII 5352200 5359400 High Signal Region +chrIII 7404700 7452200 High Signal Region +chrIII 7593800 7603300 High Signal Region +chrIII 8861100 8864700 High Signal Region +chrIII 10215600 10228400 High Signal Region +chrIII 13775100 14905900 High Signal Region +chrII 0 1300 High Signal Region +chrII 2569700 2571600 High Signal Region +chrII 3464700 3469600 High Signal Region +chrII 3795600 3798100 High Signal Region +chrII 3993700 3995700 High Signal Region +chrII 4640300 4645900 High Signal Region +chrII 5143800 5147500 High Signal Region +chrII 6504400 6509800 High Signal Region +chrII 8286700 8293600 High Signal Region +chrII 8975300 8977400 High Signal Region +chrII 9631400 9633700 High Signal Region +chrII 10335100 10339700 High Signal Region +chrII 11527100 11530900 High Signal Region +chrII 12842800 12846900 Low Mappability +chrII 13597700 13600700 Low Mappability +chrII 13983900 13987500 Low Mappability +chrII 14323700 14340100 High Signal Region +chrII 14992100 14994300 High Signal Region +chrI 669000 679400 High Signal Region +chrI 931700 935600 High Signal Region +chrI 3170700 3173300 High Signal Region +chrI 3989200 3991600 High Signal Region +chrI 4535300 4549400 High Signal Region +chrI 5151000 5154700 High Signal Region +chrI 10203200 10220100 High Signal Region +chrI 10265700 10277700 High Signal Region +chrI 10945100 10953900 High Signal Region +chrI 15059400 15373800 High Signal Region +chrIV 2821200 2831500 High Signal Region +chrIV 3205500 3210300 High Signal Region +chrIV 3365800 3368900 Low Mappability +chrIV 4415600 4422900 High Signal Region +chrIV 6357100 6361700 High Signal Region +chrIV 6468100 6470600 Low Mappability +chrIV 6682800 6704100 High Signal Region +chrIV 6709900 6734000 High Signal Region +chrIV 7590900 7600100 High Signal Region +chrIV 8563000 8582700 High Signal Region +chrIV 9045100 9049600 High Signal Region +chrIV 10942600 10951900 High Signal Region +chrIV 11070000 11076700 High Signal Region +chrIV 12313600 12325600 High Signal Region +chrIV 12637100 12639400 Low Mappability +chrIV 13359700 13362800 High Signal Region +chrIV 13548500 13550400 High Signal Region +chrIV 14056400 14059900 High Signal Region +chrIV 14775600 14782300 Low Mappability +chrIV 15408400 15424900 Low Mappability +chrV 264100 268100 High Signal Region +chrV 1103700 1106100 Low Mappability +chrV 1637000 1639900 High Signal Region +chrV 3098000 3100300 High Signal Region +chrV 3434000 3441600 High Signal Region +chrV 5072400 5084800 High Signal Region +chrV 5278300 5286700 High Signal Region +chrV 6171000 6183700 High Signal Region +chrV 6936700 6943800 High Signal Region +chrV 7442400 7445100 High Signal Region +chrV 7912200 7925700 High Signal Region +chrV 7988100 7993900 High Signal Region +chrV 8698600 8715600 High Signal Region +chrV 9423500 9436100 High Signal Region +chrV 10604900 10613200 High Signal Region +chrV 12509100 12511300 High Signal Region +chrV 14765800 14770600 High Signal Region +chrV 15425800 15436300 High Signal Region +chrV 16706300 16710300 High Signal Region +chrV 17114500 17133000 High Signal Region +chrV 17307700 17312400 High Signal Region +chrV 17383300 17395200 Low Mappability +chrV 18399500 18402500 High Signal Region +chrX 108300 115100 High Signal Region +chrX 273800 296200 High Signal Region +chrX 1635300 1645200 High Signal Region +chrX 1747400 1755900 High Signal Region +chrX 3006400 3008800 High Signal Region +chrX 4025200 4056900 High Signal Region +chrX 5045000 5058100 High Signal Region +chrX 7076500 7081700 High Signal Region +chrX 9184100 9189500 High Signal Region +chrX 9437700 9440000 High Signal Region +chrX 10360200 10369900 High Signal Region +chrX 11784800 11790300 High Signal Region +chrX 11885600 11889600 High Signal Region +chrX 12275900 12280400 High Signal Region +chrX 14384000 14390400 High Signal Region +chrX 14907200 14910200 High Signal Region +chrX 15226100 15229500 High Signal Region +chrX 15806300 15812000 Low Mappability +chrX 16757900 16761600 High Signal Region diff --git a/assets/blacklists/v2.0/ce11-blacklist.v2.bed b/assets/blacklists/v2.0/ce11-blacklist.v2.bed new file mode 100644 index 000000000..66f9d730b --- /dev/null +++ b/assets/blacklists/v2.0/ce11-blacklist.v2.bed @@ -0,0 +1,97 @@ +chrIII 449400 453600 High Signal Region +chrIII 930300 932600 High Signal Region +chrIII 1016500 1021500 Low Mappability +chrIII 1293500 1303900 High Signal Region +chrIII 5352200 5359400 High Signal Region +chrIII 7404700 7452200 High Signal Region +chrIII 7593800 7598100 High Signal Region +chrIII 8861200 8864800 High Signal Region +chrIII 10216000 10228500 High Signal Region +chrIII 13775200 13783800 High Signal Region +chrII 0 1300 High Signal Region +chrII 2569700 2571800 High Signal Region +chrII 3464700 3469600 High Signal Region +chrII 3795600 3798100 High Signal Region +chrII 3993700 3995700 High Signal Region +chrII 4640300 4645900 High Signal Region +chrII 5143800 5147500 High Signal Region +chrII 6504500 6509800 High Signal Region +chrII 8286700 8293600 High Signal Region +chrII 8975300 8977500 High Signal Region +chrII 9631500 9633800 High Signal Region +chrII 10335100 10339700 High Signal Region +chrII 11527200 11530900 High Signal Region +chrII 12842900 12846900 Low Mappability +chrII 13597800 13600800 High Signal Region +chrII 13984000 13987600 Low Mappability +chrII 14323700 14340100 High Signal Region +chrII 14992200 14994400 High Signal Region +chrI 669000 679200 High Signal Region +chrI 931700 935600 High Signal Region +chrI 3170700 3173300 High Signal Region +chrI 3989200 3991600 High Signal Region 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High Signal Region +chrIV 14775600 14782300 Low Mappability +chrIV 15076800 15082900 High Signal Region +chrIV 15408500 15424900 Low Mappability +chrV 264100 268100 High Signal Region +chrV 1103700 1106100 Low Mappability +chrV 1637000 1639900 High Signal Region +chrV 3098000 3100400 High Signal Region +chrV 3434100 3441600 High Signal Region +chrV 5278300 5286800 High Signal Region +chrV 6171000 6183700 High Signal Region +chrV 6936700 6943900 High Signal Region +chrV 7912300 7925700 High Signal Region +chrV 7988100 7993700 High Signal Region +chrV 8698700 8715700 High Signal Region +chrV 9423500 9436100 High Signal Region +chrV 10604900 10613200 High Signal Region +chrV 12509100 12511300 High Signal Region +chrV 14765800 14770600 High Signal Region +chrV 16706300 16710300 High Signal Region +chrV 17114600 17133000 High Signal Region +chrV 17307800 17312400 High Signal Region +chrV 17383300 17395200 High Signal Region +chrV 18399500 18402500 High Signal Region +chrX 108300 115100 High 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143430213 143430837 +chrX 143431144 143431537 +chrX 143431716 143432219 +chrX 143432410 143433212 +chrX 143433510 143434156 +chrX 143543636 143544023 +chrX 146995842 146996224 +chrY 4344757 4344879 +chrY 9141870 9141995 +chrY 10203380 10266932 +chrY 10316749 10544446 +chrY 10594583 10626838 +chrY 10663669 10663716 +chrY 10744417 10921497 +chrY 11290797 11334278 +chrY 11493053 11592850 +chrY 11671014 11671046 +chrY 11721528 11749472 +chrY 56694632 56889743 From d0dfe55309ed343d67885b3c9411bf7ed28fccf0 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Wed, 2 Mar 2022 17:23:53 +0100 Subject: [PATCH 329/538] Fix ECLint --- assets/blacklists/v1.0/GRCh37-blacklist.bed | 822 ++++++++++---------- 1 file changed, 411 insertions(+), 411 deletions(-) diff --git a/assets/blacklists/v1.0/GRCh37-blacklist.bed b/assets/blacklists/v1.0/GRCh37-blacklist.bed index dab19f361..b87063023 100644 --- a/assets/blacklists/v1.0/GRCh37-blacklist.bed +++ b/assets/blacklists/v1.0/GRCh37-blacklist.bed @@ -1,411 +1,411 @@ -1 564449 570371 High_Mappability_island 1000 . -1 724136 727043 Satellite_repeat 1000 . -1 825006 825115 BSR/Beta 1000 . -1 2583334 2634374 Low_mappability_island 1000 . -1 4363064 4363242 (CATTC)n 1000 . -1 5725866 5736651 Low_mappability_island 1000 . -1 16839923 16841396 Low_mappability_island 1000 . -1 38077347 38077423 Low_mappability_island 1000 . -1 91852785 91853147 LSU-rRNA_Hsa 1000 . -1 104163724 104163860 Low_mappability_island 1000 . -1 108112972 108113707 LSU-rRNA_Hsa 1000 . -1 121351474 121487059 centromeric_repeat 1000 . -1 142535434 142543081 Satellite_repeat 1000 . -1 142723256 142723968 Low_mappability_island 1000 . -1 142792613 142793303 Low_mappability_island 1000 . -1 142835822 142837333 Low_mappability_island 1000 . -1 143274490 143284340 centromeric_repeat 1000 . -1 145277108 145277572 LSU-rRNA_Hsa 1000 . -1 149033183 149035829 Satellite_repeat 1000 . -1 156186169 156186712 High_Mappability_island 1000 . -1 224199390 224204260 Satellite_repeat 1000 . 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centromeric_repeat 1000 . -14 32953263 32954381 Low_mappability_island 1000 . -14 84637832 84639038 Low_mappability_island 1000 . -14 90341302 90341516 SSU-rRNA_Hsa 1000 . -15 19999941 20044132 centromeric_repeat 1000 . -16 32493036 32570826 ALR/Alpha 1000 . -16 32590063 32598801 ALR/Alpha 1000 . -16 33237130 33241330 Low_mappability_island 1000 . -16 33864355 34023306 centromeric_repeat 1000 . -16 34180542 34197081 Satellite_repeat 1000 . -16 34530115 34542632 BSR/Beta 1000 . -16 35193580 35285885 centromeric_repeat 1000 . -16 46385718 46456668 Satellite_repeat 1000 . -16 46497639 46500515 Satellite_repeat 1000 . -16 47538629 47539297 LSU-rRNA_Hsa 1000 . -17 19355538 19356096 LSU-rRNA_Hsa 1000 . -17 19502495 19506773 Low_mappability_island 1000 . -17 21905167 21906712 centromeric_repeat 1000 . -17 22018524 22032049 Low_mappability_island 1000 . -17 22221073 22263006 centromeric_repeat 1000 . -17 25263010 25268059 Satellite_repeat 1000 . -17 25415551 25417559 telomeric_repeat 1000 . 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20378360 20379711 ALR/Alpha 1000 . -Y 20383383 20396110 ALR/Alpha 1000 . -Y 20398075 20399179 ALR/Alpha 1000 . -Y 20403581 20415713 ALR/Alpha 1000 . -Y 20487248 20487859 LSU-rRNA_Hsa 1000 . -Y 23124788 23125577 BSR/Beta 1000 . -Y 23149027 23151205 BSR/Beta 1000 . -Y 23157969 23158245 BSR/Beta 1000 . -Y 23159001 23167737 BSR/Beta 1000 . -Y 23178886 23181770 BSR/Beta 1000 . -Y 23220740 23223625 BSR/Beta 1000 . -Y 23234125 23235822 BSR/Beta 1000 . -Y 23236898 23248080 BSR/Beta 1000 . -Y 23248729 23248851 BSR/Beta 1000 . -Y 23899295 23899388 TAR1 1000 . -Y 23956449 23956628 TAR1 1000 . -Y 24247659 24247700 TAR1 1000 . -Y 24630999 24631040 TAR1 1000 . -Y 24953159 24975657 BSR/Beta 1000 . -Y 24980997 24991235 BSR/Beta 1000 . -Y 25022753 25039185 BSR/Beta 1000 . -Y 25040153 25042421 BSR/Beta 1000 . -Y 25048332 25059258 BSR/Beta 1000 . -Y 25060235 25064798 BSR/Beta 1000 . -Y 25099139 25121882 BSR/Beta 1000 . -Y 25122419 25160800 BSR/Beta 1000 . -Y 25182404 25192372 BSR/Beta 1000 . -Y 25217722 25219409 BSR/Beta 1000 . -Y 25493588 25495275 BSR/Beta 1000 . -Y 26148315 26148450 TAR1 1000 . -Y 26586905 26609405 BSR/Beta 1000 . -Y 26614745 26624983 BSR/Beta 1000 . -Y 26656502 26672934 BSR/Beta 1000 . -Y 26673902 26676170 BSR/Beta 1000 . -Y 26682081 26693007 BSR/Beta 1000 . -Y 26693984 26698547 BSR/Beta 1000 . -Y 26732883 26755623 BSR/Beta 1000 . -Y 26756160 26794538 BSR/Beta 1000 . -Y 26816148 26826116 BSR/Beta 1000 . -Y 26851466 26853153 BSR/Beta 1000 . -Y 27109247 27110934 BSR/Beta 1000 . -Y 27136281 27146249 BSR/Beta 1000 . -Y 27167859 27206241 BSR/Beta 1000 . -Y 27206778 27229502 BSR/Beta 1000 . -Y 27263848 27268411 BSR/Beta 1000 . -Y 27269388 27280315 BSR/Beta 1000 . -Y 27286226 27288494 BSR/Beta 1000 . -Y 27289462 27305895 BSR/Beta 1000 . -Y 27337415 27347656 BSR/Beta 1000 . -Y 27352996 27375497 BSR/Beta 1000 . -Y 27813984 27814119 TAR1 1000 . -Y 28555026 28555353 TAR1 1000 . -Y 28784129 28819695 Satellite_repeat 1000 . -Y 58819367 58917648 (CATTC)n 1000 . -Y 58971913 58997782 (CATTC)n 1000 . -Y 59361267 59362785 TAR1 1000 . +1 564449 570371 High_Mappability_island 1000 . +1 724136 727043 Satellite_repeat 1000 . +1 825006 825115 BSR/Beta 1000 . +1 2583334 2634374 Low_mappability_island 1000 . +1 4363064 4363242 (CATTC)n 1000 . +1 5725866 5736651 Low_mappability_island 1000 . +1 16839923 16841396 Low_mappability_island 1000 . +1 38077347 38077423 Low_mappability_island 1000 . +1 91852785 91853147 LSU-rRNA_Hsa 1000 . +1 104163724 104163860 Low_mappability_island 1000 . +1 108112972 108113707 LSU-rRNA_Hsa 1000 . +1 121351474 121487059 centromeric_repeat 1000 . +1 142535434 142543081 Satellite_repeat 1000 . +1 142723256 142723968 Low_mappability_island 1000 . +1 142792613 142793303 Low_mappability_island 1000 . +1 142835822 142837333 Low_mappability_island 1000 . +1 143274490 143284340 centromeric_repeat 1000 . +1 145277108 145277572 LSU-rRNA_Hsa 1000 . +1 149033183 149035829 Satellite_repeat 1000 . +1 156186169 156186712 High_Mappability_island 1000 . +1 224199390 224204260 Satellite_repeat 1000 . +1 233318467 233318516 (CATTC)n 1000 . +1 236260366 236260821 Low_mappability_island 1000 . +1 237766308 237766764 LSU-rRNA_Hsa 1000 . +1 238105345 238105511 Low_mappability_island 1000 . +1 238108025 238108378 Low_mappability_island 1000 . +1 238108645 238109697 Low_mappability_island 1000 . +10 18841533 18862467 (CATTC)n 1000 . +10 20035661 20037171 Low_mappability_island 1000 . +10 36722282 36723650 Low_mappability_island 1000 . +10 38772277 38819357 Satellite_repeat 1000 . +10 38868892 38889025 Satellite_repeat 1000 . +10 39076515 39155771 Satellite_repeat 1000 . +10 42354835 42548642 centromeric_repeat 1000 . +10 42596676 42602082 Satellite_repeat 1000 . +10 42596700 42602110 Satellite_repeat 1000 . +10 42661264 42667623 Satellite_repeat 1000 . +10 42790522 42818398 Satellite_repeat 1000 . +10 135498649 135502716 Satellite_repeat 1000 . +11 6831669 6831838 ALR/Alpha 1000 . +11 10529403 10531969 Low_mappability_island 1000 . +11 48671444 48902406 centromeric_repeat 1000 . +11 48931242 48964015 centromeric_repeat 1000 . +11 50318471 50784078 centromeric_repeat 1000 . +11 51090700 51374066 centromeric_repeat 1000 . +11 51567242 51594226 centromeric_repeat 1000 . +11 54694046 55027975 centromeric_repeat 1000 . +11 73221660 73221946 Low_mappability_island 1000 . +11 85194913 85195322 LSU-rRNA_Hsa 1000 . +11 87524468 87525005 Low_mappability_island 1000 . +11 103275584 103281729 Low_mappability_island 1000 . +11 122874287 122874443 Low_mappability_island 1000 . +12 20704285 20704583 SSU-rRNA_Hsa 1000 . +12 34372315 34372825 LSU-rRNA_Hsa 1000 . +12 34432130 34857010 centromeric_repeat 1000 . +12 37989447 38441828 centromeric_repeat 1000 . +12 38531376 38531930 LSU-rRNA_Hsa 1000 . +12 41757383 41757545 Low_mappability_island 1000 . +12 127650407 127651075 LSU-rRNA_Hsa 1000 . +12 132061320 132062046 Low_mappability_island 1000 . +13 56545728 56545925 Low_mappability_island 1000 . +13 110076444 110076782 Low_mappability_island 1000 . +14 18999935 19056900 centromeric_repeat 1000 . +14 32953263 32954381 Low_mappability_island 1000 . +14 84637832 84639038 Low_mappability_island 1000 . +14 90341302 90341516 SSU-rRNA_Hsa 1000 . +15 19999941 20044132 centromeric_repeat 1000 . +16 32493036 32570826 ALR/Alpha 1000 . +16 32590063 32598801 ALR/Alpha 1000 . +16 33237130 33241330 Low_mappability_island 1000 . +16 33864355 34023306 centromeric_repeat 1000 . +16 34180542 34197081 Satellite_repeat 1000 . +16 34530115 34542632 BSR/Beta 1000 . +16 35193580 35285885 centromeric_repeat 1000 . +16 46385718 46456668 Satellite_repeat 1000 . +16 46497639 46500515 Satellite_repeat 1000 . +16 47538629 47539297 LSU-rRNA_Hsa 1000 . +17 19355538 19356096 LSU-rRNA_Hsa 1000 . +17 19502495 19506773 Low_mappability_island 1000 . +17 21905167 21906712 centromeric_repeat 1000 . +17 22018524 22032049 Low_mappability_island 1000 . +17 22221073 22263006 centromeric_repeat 1000 . +17 25263010 25268059 Satellite_repeat 1000 . +17 25415551 25417559 telomeric_repeat 1000 . +17 31149365 31149981 High_Mappability_island 1000 . +17 33478114 33478372 LSU-rRNA_Hsa 1000 . +17 41381502 41382591 High_Mappability_island 1000 . +17 41463538 41464075 High_Mappability_island 1000 . +17 41464478 41465015 snRNA 1000 . +17 41465562 41467288 High_Mappability_island 1000 . +17 51183038 51183763 Low_mappability_island 1000 . +17 55868618 55868752 LSU-rRNA_Hsa 1000 . +17 75158031 75158430 LSU-rRNA_Hsa 1000 . +18 96416 97552 Satellite_repeat 1000 . +18 105658 112233 Satellite_repeat 1000 . +18 2842252 2842356 Low_mappability_island 1000 . +18 15393801 15393992 centromeric_repeat 1000 . +18 18510894 18520356 centromeric_repeat 1000 . +18 44126235 44126593 (CATTC)n 1000 . +18 45379603 45379864 Low_mappability_island 1000 . +18 50319086 50319301 Low_mappability_island 1000 . +18 77772846 77773065 LSU-rRNA_Hsa 1000 . +19 246006 247844 TAR1 1000 . +19 22877614 22877696 SSU-rRNA_Hsa 1000 . +19 23235030 23235504 BSR/Beta 1000 . +19 24182398 24186210 LSU-rRNA_Hsa 1000 . +19 24385474 24633168 centromeric_repeat 1000 . +19 27730611 28262682 centromeric_repeat 1000 . +19 36066445 36066810 LSU-rRNA_Hsa 1000 . +19 36756398 36800948 centromeric_repeat 1000 . +19 37759473 37797722 centromeric_repeat 1000 . +19 44914313 44916340 ACRO1 1000 . +19 44960681 44962681 ACRO1 1000 . +2 739925 740994 Low_mappability_island 1000 . +2 49456729 49457067 Low_mappability_island 1000 . +2 88124390 88124903 Low_mappability_island 1000 . +2 89830421 89880514 Satellite_repeat 1000 . +2 90371401 90394776 Satellite_repeat 1000 . +2 90443001 90545431 Low_mappability_island 1000 . +2 91595080 91616015 Satellite_repeat 1000 . +2 92267428 92326280 centromeric_repeat 1000 . +2 115695017 115695281 LSU-rRNA_Hsa 1000 . +2 117781085 117781300 Low_mappability_island 1000 . +2 132966248 132989300 centromeric_repeat 1000 . +2 132994855 133007983 ALR/Alpha 1000 . +2 133011824 133013298 SSU-rRNA_Hsa 1000 . +2 133036250 133040042 LSU-rRNA_Hsa 1000 . +2 133044095 133045945 ACRO1 1000 . +2 143848503 143848792 Low_mappability_island 1000 . +2 148022736 148022878 Low_mappability_island 1000 . +2 149639207 149639515 Low_mappability_island 1000 . +2 156120500 156120610 Low_mappability_island 1000 . +2 162135000 162139241 Low_mappability_island 1000 . +2 230045426 230045796 LSU-rRNA_Hsa 1000 . +20 26257032 26320267 centromeric_repeat 1000 . +20 29517710 29521147 centromeric_repeat 1000 . +20 29803876 29833334 centromeric_repeat 1000 . +20 55932703 55936114 chrM 1000 . +20 62916702 62918053 telomeric_repeat 1000 . +21 9647205 9648529 Low_mappability_island 1000 . +21 9694896 9704962 centromeric_repeat 1000 . +21 9825451 9827612 High_Mappability_island 1000 . +21 9827612 9845233 Low_mappability_island 1000 . +21 9881895 9882569 TAR1 1000 . +21 10084922 10088004 Satellite_repeat 1000 . +21 10492876 10493049 Low_mappability_island 1000 . +21 10599428 10599915 TAR1 1000 . +21 10697886 10860890 centromeric_repeat 1000 . +21 11186054 11188131 Satellite_repeat 1000 . +21 14338127 14369791 centromeric_repeat 1000 . +21 18800575 18800997 (GAGTG)n 1000 . +21 27228003 27228242 SSU-rRNA_Hsa 1000 . +21 46796081 46796336 Low_mappability_island 1000 . +22 16847814 16862659 Satellite_repeat 1000 . +22 18876789 18884510 Satellite_repeat 1000 . +3 25508897 25509131 Low_mappability_island 1000 . +3 73159606 73161131 snRNA 1000 . +3 75696297 75699304 BSR/Beta 1000 . +3 75717841 75720426 Satellite_repeat 1000 . +3 80995858 81014459 ALR/Alpha 1000 . +3 90311686 90507410 centromeric_repeat 1000 . +3 93504815 93519133 centromeric_repeat 1000 . +3 96335934 96337436 Low_mappability_island 1000 . +3 160665423 160665642 Low_mappability_island 1000 . +3 196625514 196625860 Satellite_repeat 1000 . +3 197825427 197834080 Low_mappability_island 1000 . +4 9987 12694 telomeric_repeat 1000 . +4 12276463 12292424 ALR/Alpha 1000 . +4 12641862 12642305 Low_mappability_island 1000 . +4 21583630 21583719 (GAATG)n 1000 . +4 27732004 27732240 Low_mappability_island 1000 . +4 47774268 47774416 Low_mappability_island 1000 . +4 49085372 49342114 centromeric_repeat 1000 . +4 49488472 49662085 centromeric_repeat 1000 . +4 52659961 52688986 centromeric_repeat 1000 . +4 56194229 56194584 Low_mappability_island 1000 . +4 65473858 65473941 Low_mappability_island 1000 . +4 68264186 68266830 centromeric_repeat 1000 . +4 70296565 70296841 LSU-rRNA_Hsa 1000 . +4 76807083 76807320 LSU-rRNA_Hsa 1000 . +4 78929660 78929920 Low_mappability_island 1000 . +4 156374749 156377226 chrM 1000 . +4 156384860 156387314 Low_mappability_island 1000 . +4 163342479 163342744 Low_mappability_island 1000 . +4 190190746 190203442 Low_mappability_island 1000 . +4 190801869 190802909 Low_mappability_island 1000 . +4 190943802 190943962 Satellite_repeat 1000 . +4 190987268 190990949 Satellite_repeat 1000 . +4 191026302 191044344 telomeric_repeat 1000 . +5 17517177 17600940 Low_mappability_island 1000 . +5 21477365 21497415 Low_mappability_island 1000 . +5 34177882 34197574 Low_mappability_island 1000 . +5 45908253 46411114 centromeric_repeat 1000 . +5 49405493 49554574 centromeric_repeat 1000 . +5 71146650 71146996 LSU-rRNA_Hsa 1000 . +5 79945807 79948223 Low_mappability_island 1000 . +5 93903068 93906726 Low_mappability_island 1000 . +5 97746525 97746679 Low_mappability_island 1000 . +5 99381556 99390873 Low_mappability_island 1000 . +5 105889063 105889263 chrM 1000 . +5 123095972 123097432 chrM 1000 . +5 134258949 134264271 Low_mappability_island 1000 . +5 174541634 174542177 SSU-rRNA_Hsa 1000 . +6 58735349 58739031 centromeric_repeat 1000 . +6 58745955 58780547 centromeric_repeat 1000 . +6 61880095 61944008 centromeric_repeat 1000 . +6 62189892 62206612 ALR/Alpha 1000 . +6 62207809 62230644 ALR/Alpha 1000 . +6 62283966 62284581 Low_mappability_island 1000 . +6 133593944 133594201 LSU-rRNA_Hsa 1000 . +6 137059142 137059326 SSU-rRNA_Hsa 1000 . +6 150665074 150665281 SSU-rRNA_Hsa 1000 . +6 157731310 157735525 Low_mappability_island 1000 . +7 43878355 43878530 TAR1 1000 . +7 45291517 45291740 Low_mappability_island 1000 . +7 56437808 56442977 Low_mappability_island 1000 . +7 57253980 57254183 Low_mappability_island 1000 . +7 57255310 57255444 Low_mappability_island 1000 . +7 57261829 57261998 Low_mappability_island 1000 . +7 57544726 57556913 Satellite_repeat 1000 . +7 57811488 57836990 centromeric_repeat 1000 . +7 57939184 58055539 centromeric_repeat 1000 . +7 61054285 62454680 centromeric_repeat 1000 . +7 64059157 64066183 BSR/Beta 1000 . +7 64951348 64956223 centromeric_repeat 1000 . +7 68201468 68201673 Low_mappability_island 1000 . +7 68527370 68527788 LSU-rRNA_Hsa 1000 . +7 80962907 80963147 SSU-rRNA_Hsa 1000 . +7 100550640 100551321 Low_mappability_island 1000 . +7 142372972 142375638 Low_mappability_island 1000 . +7 145694403 145694561 Low_mappability_island 1000 . +8 155512 157639 TAR1 1000 . +8 21455971 21456306 LSU-rRNA_Hsa 1000 . +8 32868966 32873279 Low_mappability_island 1000 . +8 43092737 43097573 Satellite_repeat 1000 . +8 43399486 43843604 centromeric_repeat 1000 . +8 46838215 47457541 centromeric_repeat 1000 . +8 47739043 47742797 Low_mappability_island 1000 . +8 47750844 47776101 BSR/Beta 1000 . +8 56754955 56755418 LSU-rRNA_Hsa 1000 . +8 69218401 69218922 LSU-rRNA_Hsa 1000 . +8 70602248 70602620 LSU-rRNA_Hsa 1000 . +8 77114154 77114389 Low_mappability_island 1000 . +8 100508010 100508287 Low_mappability_island 1000 . +9 10435 11574 TAR1 1000 . +9 4799734 4800000 SSU-rRNA_Hsa 1000 . +9 33656606 33659249 Low_mappability_island 1000 . +9 42819021 42832395 centromeric_repeat 1000 . +9 44070617 44070871 Low_mappability_island 1000 . +9 44873123 44902307 centromeric_repeat 1000 . +9 45355954 45357644 telomeric_repeat 1000 . +9 45435109 45443517 centromeric_repeat 1000 . +9 66494170 66494805 TAR1 1000 . +9 66767710 66864329 centromeric_repeat 1000 . +9 66970914 67005594 centromeric_repeat 1000 . +9 67315122 67321036 centromeric_repeat 1000 . +9 67789868 67792893 centromeric_repeat 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centromeric_repeat 1000 . +X 58488898 58494528 centromeric_repeat 1000 . +X 58499466 58504235 centromeric_repeat 1000 . +X 58506076 58528214 centromeric_repeat 1000 . +X 58528184 58536883 centromeric_repeat 1000 . +X 58544061 58582415 centromeric_repeat 1000 . +X 61681834 61919683 centromeric_repeat 1000 . +X 62003205 62041580 centromeric_repeat 1000 . +X 83658929 83659019 Low_mappability_island 1000 . +X 108297348 108297886 LSU-rRNA_Hsa 1000 . +X 114959057 115006437 Low_mappability_island 1000 . +X 125605623 125607351 Low_mappability_island 1000 . +X 125714985 125715338 Low_mappability_island 1000 . +X 125864844 125864980 Low_mappability_island 1000 . +X 125865719 125865874 Low_mappability_island 1000 . +Y 313470 313613 ALR/Alpha 1000 . +Y 3004989 3005175 LSU-rRNA_Hsa 1000 . +Y 4212807 4212910 Low_mappability_island 1000 . +Y 7671817 7694928 BSR/Beta 1000 . +Y 7726064 7730229 BSR/Beta 1000 . +Y 7730734 7731598 BSR/Beta 1000 . +Y 7735811 7752887 BSR/Beta 1000 . +Y 7785067 7806311 BSR/Beta 1000 . +Y 7806856 7814704 BSR/Beta 1000 . +Y 7815230 7820478 BSR/Beta 1000 . +Y 7829937 7832032 BSR/Beta 1000 . +Y 7832744 7848695 BSR/Beta 1000 . +Y 7870343 7873582 BSR/Beta 1000 . +Y 7874115 7874584 BSR/Beta 1000 . +Y 7875409 7885257 BSR/Beta 1000 . +Y 7886545 7894591 BSR/Beta 1000 . +Y 7898927 7916812 BSR/Beta 1000 . +Y 7918790 7921352 BSR/Beta 1000 . +Y 7926344 7936705 BSR/Beta 1000 . +Y 7941130 7947438 BSR/Beta 1000 . +Y 7948790 7964448 BSR/Beta 1000 . +Y 8179010 8181143 BSR/Beta 1000 . +Y 8181757 8213330 BSR/Beta 1000 . +Y 8214629 8215637 BSR/Beta 1000 . +Y 8220421 8230061 BSR/Beta 1000 . +Y 8230686 8231546 BSR/Beta 1000 . +Y 8240772 8265916 BSR/Beta 1000 . +Y 8291535 8292942 BSR/Beta 1000 . +Y 8294002 8295175 BSR/Beta 1000 . +Y 8296944 8321375 BSR/Beta 1000 . +Y 8325813 8325929 BSR/Beta 1000 . +Y 8326678 8333466 BSR/Beta 1000 . +Y 8334027 8342387 BSR/Beta 1000 . +Y 8356544 8369346 BSR/Beta 1000 . +Y 8909560 8909925 TAR1 1000 . +Y 8979478 8979585 Low_mappability_island 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20362679 20371694 ALR/Alpha 1000 . +Y 20378360 20379711 ALR/Alpha 1000 . +Y 20383383 20396110 ALR/Alpha 1000 . +Y 20398075 20399179 ALR/Alpha 1000 . +Y 20403581 20415713 ALR/Alpha 1000 . +Y 20487248 20487859 LSU-rRNA_Hsa 1000 . +Y 23124788 23125577 BSR/Beta 1000 . +Y 23149027 23151205 BSR/Beta 1000 . +Y 23157969 23158245 BSR/Beta 1000 . +Y 23159001 23167737 BSR/Beta 1000 . +Y 23178886 23181770 BSR/Beta 1000 . +Y 23220740 23223625 BSR/Beta 1000 . +Y 23234125 23235822 BSR/Beta 1000 . +Y 23236898 23248080 BSR/Beta 1000 . +Y 23248729 23248851 BSR/Beta 1000 . +Y 23899295 23899388 TAR1 1000 . +Y 23956449 23956628 TAR1 1000 . +Y 24247659 24247700 TAR1 1000 . +Y 24630999 24631040 TAR1 1000 . +Y 24953159 24975657 BSR/Beta 1000 . +Y 24980997 24991235 BSR/Beta 1000 . +Y 25022753 25039185 BSR/Beta 1000 . +Y 25040153 25042421 BSR/Beta 1000 . +Y 25048332 25059258 BSR/Beta 1000 . +Y 25060235 25064798 BSR/Beta 1000 . +Y 25099139 25121882 BSR/Beta 1000 . +Y 25122419 25160800 BSR/Beta 1000 . +Y 25182404 25192372 BSR/Beta 1000 . +Y 25217722 25219409 BSR/Beta 1000 . +Y 25493588 25495275 BSR/Beta 1000 . +Y 26148315 26148450 TAR1 1000 . +Y 26586905 26609405 BSR/Beta 1000 . +Y 26614745 26624983 BSR/Beta 1000 . +Y 26656502 26672934 BSR/Beta 1000 . +Y 26673902 26676170 BSR/Beta 1000 . +Y 26682081 26693007 BSR/Beta 1000 . +Y 26693984 26698547 BSR/Beta 1000 . +Y 26732883 26755623 BSR/Beta 1000 . +Y 26756160 26794538 BSR/Beta 1000 . +Y 26816148 26826116 BSR/Beta 1000 . +Y 26851466 26853153 BSR/Beta 1000 . +Y 27109247 27110934 BSR/Beta 1000 . +Y 27136281 27146249 BSR/Beta 1000 . +Y 27167859 27206241 BSR/Beta 1000 . +Y 27206778 27229502 BSR/Beta 1000 . +Y 27263848 27268411 BSR/Beta 1000 . +Y 27269388 27280315 BSR/Beta 1000 . +Y 27286226 27288494 BSR/Beta 1000 . +Y 27289462 27305895 BSR/Beta 1000 . +Y 27337415 27347656 BSR/Beta 1000 . +Y 27352996 27375497 BSR/Beta 1000 . +Y 27813984 27814119 TAR1 1000 . +Y 28555026 28555353 TAR1 1000 . +Y 28784129 28819695 Satellite_repeat 1000 . +Y 58819367 58917648 (CATTC)n 1000 . +Y 58971913 58997782 (CATTC)n 1000 . +Y 59361267 59362785 TAR1 1000 . From f94f5244a42e7957061cbdcf209cb341a276e0ae Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Wed, 2 Mar 2022 17:26:42 +0100 Subject: [PATCH 330/538] Rename GRCh37 blacklist --- .../v1.0/{GRCh37-blacklist.bed => GRCh37-blacklist.v1.bed} | 0 1 file changed, 0 insertions(+), 0 deletions(-) rename assets/blacklists/v1.0/{GRCh37-blacklist.bed => GRCh37-blacklist.v1.bed} (100%) diff --git a/assets/blacklists/v1.0/GRCh37-blacklist.bed b/assets/blacklists/v1.0/GRCh37-blacklist.v1.bed similarity index 100% rename from assets/blacklists/v1.0/GRCh37-blacklist.bed rename to assets/blacklists/v1.0/GRCh37-blacklist.v1.bed From b7eb970cb257cb0bef5f05c239a76a30946dc815 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Wed, 2 Mar 2022 17:29:17 +0100 Subject: [PATCH 331/538] Template update for nf-core/tools version 2.2 --- LICENSE | 2 +- README.md | 2 +- docs/images/nf-core-chipseq_logo_light.png | Bin 428 -> 73788 bytes nextflow.config | 2 +- 4 files changed, 3 insertions(+), 3 deletions(-) diff --git a/LICENSE b/LICENSE index 2a0f576bc..e6309f574 100644 --- a/LICENSE +++ b/LICENSE @@ -1,6 +1,6 @@ MIT License -Copyright (c) Philip Ewels +Copyright (c) Philip Ewels, Jose Espinosa-Carrasco, Harshil Patel Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal diff --git a/README.md b/README.md index 5dcdd654d..541726426 100644 --- a/README.md +++ b/README.md @@ -64,7 +64,7 @@ The nf-core/chipseq pipeline comes with documentation about the pipeline [usage] ## Credits -nf-core/chipseq was originally written by Philip Ewels. +nf-core/chipseq was originally written by Philip Ewels, Jose Espinosa-Carrasco, Harshil Patel. 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J-waT~81OO72jb}RoLJM9sUyE8jGGwP=P zT({r52Hx8DE$sF$+szslcT#Se_EpNdtuM&KawTQ+v8aUV!(c1b6Y4w!6D(Cvt4H`E zKADbS@9>1i;=z)V7g#7c)78Q2R21&3KiPRN)L6AW!IagA!AuZn7(F8!n;^O(3&GEL z`IdZS!SoYp3ZUbR4QN~-hc4sVpItBmfoJG&#Lk2yM)p}|n3k}!gi}7^1bED6U@;Ic zl^ka$&sv*cyhCf#Eg<}pQxJ33KjQ@CIv?|QCJpD_6tkR+I~LC|e?kXMA=kc(1G!N4 VJvv>8IrcTl)qtG)%H@^D#V=*Sk$eCE diff --git a/nextflow.config b/nextflow.config index e5ae4e45b..d771f6620 100644 --- a/nextflow.config +++ b/nextflow.config @@ -154,7 +154,7 @@ dag { manifest { name = 'nf-core/chipseq' - author = 'Philip Ewels' + author = 'Philip Ewels, Jose Espinosa-Carrasco, Harshil Patel' homePage = 'https://github.com/nf-core/chipseq' description = 'ChIP-seq peak-calling and differential analysis pipeline.' mainScript = 'main.nf' From 66bfcfcb4789ecf08e50da5f7ce14a4de0de162e Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Wed, 2 Mar 2022 17:32:44 +0100 Subject: [PATCH 332/538] Template update for nf-core/tools version 2.3.dev0 --- .github/ISSUE_TEMPLATE/bug_report.yml | 1 - .github/workflows/awsfulltest.yml | 8 +-- .github/workflows/awstest.yml | 8 +-- .github/workflows/linting.yml | 28 ++++------ .gitpod.yml | 14 +++++ .nf-core.yml | 1 + .yamllint.yml | 6 ++ README.md | 2 +- conf/base.config | 4 +- conf/igenomes.config | 80 +++++++++++++-------------- conf/modules.config | 10 ++-- conf/test.config | 4 +- conf/test_full.config | 4 +- docs/usage.md | 19 +++++-- lib/NfcoreSchema.groovy | 4 +- lib/Utils.groovy | 4 +- lib/WorkflowChipseq.groovy | 4 +- main.nf | 24 ++++---- nextflow.config | 7 ++- nextflow_schema.json | 16 ++++++ workflows/chipseq.nf | 28 +++++----- 21 files changed, 158 insertions(+), 118 deletions(-) create mode 100644 .gitpod.yml create mode 100644 .nf-core.yml create mode 100644 .yamllint.yml diff --git a/.github/ISSUE_TEMPLATE/bug_report.yml b/.github/ISSUE_TEMPLATE/bug_report.yml index b0d2788d9..ecfb25027 100644 --- a/.github/ISSUE_TEMPLATE/bug_report.yml +++ b/.github/ISSUE_TEMPLATE/bug_report.yml @@ -1,4 +1,3 @@ - name: Bug report description: Report something that is broken or incorrect labels: bug diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index a5e2cade9..b6dc1488b 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -14,7 +14,7 @@ jobs: runs-on: ubuntu-latest steps: - name: Launch workflow via tower - uses: nf-core/tower-action@v2 + uses: nf-core/tower-action@v3 # TODO nf-core: You can customise AWS full pipeline tests as required # Add full size test data (but still relatively small datasets for few samples) # on the `test_full.config` test runs with only one set of parameters @@ -23,12 +23,12 @@ jobs: workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }} access_token: ${{ secrets.TOWER_ACCESS_TOKEN }} compute_env: ${{ secrets.TOWER_COMPUTE_ENV }} - pipeline: ${{ github.repository }} - revision: ${{ github.sha }} workdir: s3://${{ secrets.AWS_S3_BUCKET }}/work/chipseq/work-${{ github.sha }} parameters: | { "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-${{ github.sha }}" } profiles: test_full,aws_tower - pre_run_script: 'export NXF_VER=21.10.3' + nextflow_config: | + process.errorStrategy = 'retry' + process.maxRetries = 3 diff --git a/.github/workflows/awstest.yml b/.github/workflows/awstest.yml index b8f720cbe..8a2ea6259 100644 --- a/.github/workflows/awstest.yml +++ b/.github/workflows/awstest.yml @@ -11,18 +11,18 @@ jobs: runs-on: ubuntu-latest steps: - name: Launch workflow via tower - uses: nf-core/tower-action@v2 + uses: nf-core/tower-action@v3 with: workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }} access_token: ${{ secrets.TOWER_ACCESS_TOKEN }} compute_env: ${{ secrets.TOWER_COMPUTE_ENV }} - pipeline: ${{ github.repository }} - revision: ${{ github.sha }} workdir: s3://${{ secrets.AWS_S3_BUCKET }}/work/chipseq/work-${{ github.sha }} parameters: | { "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-test-${{ github.sha }}" } profiles: test,aws_tower - pre_run_script: 'export NXF_VER=21.10.3' + nextflow_config: | + process.errorStrategy = 'retry' + process.maxRetries = 3 diff --git a/.github/workflows/linting.yml b/.github/workflows/linting.yml index 3b448773c..fda934c03 100644 --- a/.github/workflows/linting.yml +++ b/.github/workflows/linting.yml @@ -12,9 +12,7 @@ jobs: runs-on: ubuntu-latest steps: - uses: actions/checkout@v2 - - uses: actions/setup-node@v1 - with: - node-version: '10' + - uses: actions/setup-node@v2 - name: Install markdownlint run: npm install -g markdownlint-cli - name: Run Markdownlint @@ -51,9 +49,7 @@ jobs: steps: - uses: actions/checkout@v2 - - uses: actions/setup-node@v1 - with: - node-version: '10' + - uses: actions/setup-node@v2 - name: Install editorconfig-checker run: npm install -g editorconfig-checker @@ -64,14 +60,13 @@ jobs: YAML: runs-on: ubuntu-latest steps: - - uses: actions/checkout@v1 - - uses: actions/setup-node@v1 + - name: Checkout + uses: actions/checkout@master + - name: 'Yamllint' + uses: karancode/yamllint-github-action@master with: - node-version: '10' - - name: Install yaml-lint - run: npm install -g yaml-lint - - name: Run yaml-lint - run: yamllint $(find ${GITHUB_WORKSPACE} -type f -name "*.yml" -o -name "*.yaml") + yamllint_file_or_dir: '.' + yamllint_config_filepath: '.yamllint.yml' # If the above check failed, post a comment on the PR explaining the failure - name: Post PR comment @@ -84,10 +79,11 @@ jobs: To keep the code consistent with lots of contributors, we run automated code consistency checks. To fix this CI test, please run: - * Install `yaml-lint` - * [Install `npm`](https://www.npmjs.com/get-npm) then [install `yaml-lint`](https://www.npmjs.com/package/yaml-lint) (`npm install -g yaml-lint`) + * Install `yamllint` + * Install `yamllint` following [this](https://yamllint.readthedocs.io/en/stable/quickstart.html#installing-yamllint) + instructions or alternative install it in your [conda environment](https://anaconda.org/conda-forge/yamllint) * Fix the markdown errors - * Run the test locally: `yamllint $(find . -type f -name "*.yml" -o -name "*.yaml")` + * Run the test locally: `yamllint $(find . -type f -name "*.yml" -o -name "*.yaml") -c ./.yamllint.yml` * Fix any reported errors in your YAML files Once you push these changes the test should pass, and you can hide this comment :+1: diff --git a/.gitpod.yml b/.gitpod.yml new file mode 100644 index 000000000..b7d4cee18 --- /dev/null +++ b/.gitpod.yml @@ -0,0 +1,14 @@ +image: nfcore/gitpod:latest + +vscode: + extensions: # based on nf-core.nf-core-extensionpack + - codezombiech.gitignore # Language support for .gitignore files + # - cssho.vscode-svgviewer # SVG viewer + - davidanson.vscode-markdownlint # Markdown/CommonMark linting and style checking for Visual Studio Code + - eamodio.gitlens # Quickly glimpse into whom, why, and when a line or code block was changed + - EditorConfig.EditorConfig # override user/workspace settings with settings found in .editorconfig files + - Gruntfuggly.todo-tree # Display TODO and FIXME in a tree view in the activity bar + - mechatroner.rainbow-csv # Highlight columns in csv files in different colors + # - nextflow.nextflow # Nextflow syntax highlighting + - oderwat.indent-rainbow # Highlight indentation level + - streetsidesoftware.code-spell-checker # Spelling checker for source code diff --git a/.nf-core.yml b/.nf-core.yml new file mode 100644 index 000000000..3805dc81c --- /dev/null +++ b/.nf-core.yml @@ -0,0 +1 @@ +repository_type: pipeline diff --git a/.yamllint.yml b/.yamllint.yml new file mode 100644 index 000000000..d466deec9 --- /dev/null +++ b/.yamllint.yml @@ -0,0 +1,6 @@ +extends: default + +rules: + document-start: disable + line-length: disable + truthy: disable diff --git a/README.md b/README.md index 541726426..9fe7977b5 100644 --- a/README.md +++ b/README.md @@ -47,7 +47,7 @@ On release, automated continuous integration tests run the pipeline on a full-si > * The pipeline comes with config profiles called `docker`, `singularity`, `podman`, `shifter`, `charliecloud` and `conda` which instruct the pipeline to use the named tool for software management. For example, `-profile test,docker`. > * Please check [nf-core/configs](https://github.com/nf-core/configs#documentation) to see if a custom config file to run nf-core pipelines already exists for your Institute. If so, you can simply use `-profile ` in your command. This will enable either `docker` or `singularity` and set the appropriate execution settings for your local compute environment. - > * If you are using `singularity` and are persistently observing issues downloading Singularity images directly due to timeout or network issues, then you can use the `--singularity_pull_docker_container` parameter to pull and convert the Docker image instead. Alternatively, you can use the [`nf-core download`](https://nf-co.re/tools/#downloading-pipelines-for-offline-use) command to download images first, before running the pipeline. Setting the [`NXF_SINGULARITY_CACHEDIR` or `singularity.cacheDir`](https://www.nextflow.io/docs/latest/singularity.html?#singularity-docker-hub) Nextflow options enables you to store and re-use the images from a central location for future pipeline runs. + > * If you are using `singularity`, please use the [`nf-core download`](https://nf-co.re/tools/#downloading-pipelines-for-offline-use) command to download images first, before running the pipeline. Setting the [`NXF_SINGULARITY_CACHEDIR` or `singularity.cacheDir`](https://www.nextflow.io/docs/latest/singularity.html?#singularity-docker-hub) Nextflow options enables you to store and re-use the images from a central location for future pipeline runs. > * If you are using `conda`, it is highly recommended to use the [`NXF_CONDA_CACHEDIR` or `conda.cacheDir`](https://www.nextflow.io/docs/latest/conda.html) settings to store the environments in a central location for future pipeline runs. 4. Start running your own analysis! diff --git a/conf/base.config b/conf/base.config index 07779064b..8231c4796 100644 --- a/conf/base.config +++ b/conf/base.config @@ -1,7 +1,7 @@ /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ nf-core/chipseq Nextflow base config file -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ A 'blank slate' config file, appropriate for general use on most high performance compute environments. Assumes that all software is installed and available on the PATH. Runs in `local` mode - all jobs will be run on the logged in environment. diff --git a/conf/igenomes.config b/conf/igenomes.config index 855948def..7a1b3ac6d 100644 --- a/conf/igenomes.config +++ b/conf/igenomes.config @@ -1,7 +1,7 @@ /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Nextflow config file for iGenomes paths -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Defines reference genomes using iGenome paths. Can be used by any config that customises the base path using: $params.igenomes_base / --igenomes_base @@ -13,7 +13,7 @@ params { genomes { 'GRCh37' { fasta = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BismarkIndex/" @@ -26,7 +26,7 @@ params { } 'GRCh38' { fasta = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BismarkIndex/" @@ -38,7 +38,7 @@ params { } 'GRCm38' { fasta = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BismarkIndex/" @@ -51,7 +51,7 @@ params { } 'TAIR10' { fasta = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BismarkIndex/" @@ -62,7 +62,7 @@ params { } 'EB2' { fasta = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BismarkIndex/" @@ -72,7 +72,7 @@ params { } 'UMD3.1' { fasta = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BismarkIndex/" @@ -83,7 +83,7 @@ params { } 'WBcel235' { fasta = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BismarkIndex/" @@ -94,7 +94,7 @@ params { } 'CanFam3.1' { fasta = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BismarkIndex/" @@ -105,7 +105,7 @@ params { } 'GRCz10' { fasta = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BismarkIndex/" @@ -115,7 +115,7 @@ params { } 'BDGP6' { fasta = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BismarkIndex/" @@ -126,7 +126,7 @@ params { } 'EquCab2' { fasta = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BismarkIndex/" @@ -137,7 +137,7 @@ params { } 'EB1' { fasta = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BismarkIndex/" @@ -147,7 +147,7 @@ params { } 'Galgal4' { fasta = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BismarkIndex/" @@ -157,7 +157,7 @@ params { } 'Gm01' { fasta = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BismarkIndex/" @@ -167,7 +167,7 @@ params { } 'Mmul_1' { fasta = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BismarkIndex/" @@ -178,7 +178,7 @@ params { } 'IRGSP-1.0' { fasta = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BismarkIndex/" @@ -188,7 +188,7 @@ params { } 'CHIMP2.1.4' { fasta = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BismarkIndex/" @@ -199,7 +199,7 @@ params { } 'Rnor_5.0' { fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/BismarkIndex/" @@ -209,7 +209,7 @@ params { } 'Rnor_6.0' { fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BismarkIndex/" @@ -219,7 +219,7 @@ params { } 'R64-1-1' { fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BismarkIndex/" @@ -230,7 +230,7 @@ params { } 'EF2' { fasta = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BismarkIndex/" @@ -242,7 +242,7 @@ params { } 'Sbi1' { fasta = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BismarkIndex/" @@ -252,7 +252,7 @@ params { } 'Sscrofa10.2' { fasta = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BismarkIndex/" @@ -263,7 +263,7 @@ params { } 'AGPv3' { fasta = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BismarkIndex/" @@ -273,7 +273,7 @@ params { } 'hg38' { fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BismarkIndex/" @@ -285,7 +285,7 @@ params { } 'hg19' { fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BismarkIndex/" @@ -298,7 +298,7 @@ params { } 'mm10' { fasta = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BismarkIndex/" @@ -311,7 +311,7 @@ params { } 'bosTau8' { fasta = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BismarkIndex/" @@ -321,7 +321,7 @@ params { } 'ce10' { fasta = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BismarkIndex/" @@ -333,7 +333,7 @@ params { } 'canFam3' { fasta = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BismarkIndex/" @@ -344,7 +344,7 @@ params { } 'danRer10' { fasta = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BismarkIndex/" @@ -355,7 +355,7 @@ params { } 'dm6' { fasta = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BismarkIndex/" @@ -366,7 +366,7 @@ params { } 'equCab2' { fasta = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BismarkIndex/" @@ -377,7 +377,7 @@ params { } 'galGal4' { fasta = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BismarkIndex/" @@ -388,7 +388,7 @@ params { } 'panTro4' { fasta = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BismarkIndex/" @@ -399,7 +399,7 @@ params { } 'rn6' { fasta = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BismarkIndex/" @@ -409,7 +409,7 @@ params { } 'sacCer3' { fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BismarkIndex/" @@ -419,7 +419,7 @@ params { } 'susScr3' { fasta = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BismarkIndex/" diff --git a/conf/modules.config b/conf/modules.config index a0506a4db..6b9870439 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -1,7 +1,7 @@ /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Config file for defining DSL2 per module options and publishing paths -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Available keys to override module options: ext.args = Additional arguments appended to command in module. ext.args2 = Second set of arguments appended to command in module (multi-tool modules). @@ -14,14 +14,14 @@ process { publishDir = [ path: { "${params.outdir}/${task.process.tokenize(':')[-1].tokenize('_')[0].toLowerCase()}" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] withName: SAMPLESHEET_CHECK { publishDir = [ path: { "${params.outdir}/pipeline_info" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -33,7 +33,7 @@ process { withName: CUSTOM_DUMPSOFTWAREVERSIONS { publishDir = [ path: { "${params.outdir}/pipeline_info" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: '*_versions.yml' ] } diff --git a/conf/test.config b/conf/test.config index 3a199a627..c31e8db7a 100644 --- a/conf/test.config +++ b/conf/test.config @@ -1,7 +1,7 @@ /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Nextflow config file for running minimal tests -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Defines input files and everything required to run a fast and simple pipeline test. Use as follows: diff --git a/conf/test_full.config b/conf/test_full.config index d8fe4234c..49cf8e434 100644 --- a/conf/test_full.config +++ b/conf/test_full.config @@ -1,7 +1,7 @@ /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Nextflow config file for running full-size tests -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Defines input files and everything required to run a full size pipeline test. Use as follows: diff --git a/docs/usage.md b/docs/usage.md index d1e7eebc7..7eb149bae 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -141,11 +141,11 @@ Whilst the default requirements set within the pipeline will hopefully work for For example, if the nf-core/rnaseq pipeline is failing after multiple re-submissions of the `STAR_ALIGN` process due to an exit code of `137` this would indicate that there is an out of memory issue: ```console -[62/149eb0] NOTE: Process `RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)` terminated with an error exit status (137) -- Execution is retried (1) -Error executing process > 'RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)' +[62/149eb0] NOTE: Process `NFCORE_RNASEQ:RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)` terminated with an error exit status (137) -- Execution is retried (1) +Error executing process > 'NFCORE_RNASEQ:RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)' Caused by: - Process `RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)` terminated with an error exit status (137) + Process `NFCORE_RNASEQ:RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)` terminated with an error exit status (137) Command executed: STAR \ @@ -169,17 +169,24 @@ Work dir: Tip: you can replicate the issue by changing to the process work dir and entering the command `bash .command.run` ``` -To bypass this error you would need to find exactly which resources are set by the `STAR_ALIGN` process. The quickest way is to search for `process STAR_ALIGN` in the [nf-core/rnaseq Github repo](https://github.com/nf-core/rnaseq/search?q=process+STAR_ALIGN). We have standardised the structure of Nextflow DSL2 pipelines such that all module files will be present in the `modules/` directory and so based on the search results the file we want is `modules/nf-core/software/star/align/main.nf`. If you click on the link to that file you will notice that there is a `label` directive at the top of the module that is set to [`label process_high`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/modules/nf-core/software/star/align/main.nf#L9). The [Nextflow `label`](https://www.nextflow.io/docs/latest/process.html#label) directive allows us to organise workflow processes in separate groups which can be referenced in a configuration file to select and configure subset of processes having similar computing requirements. The default values for the `process_high` label are set in the pipeline's [`base.config`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/base.config#L33-L37) which in this case is defined as 72GB. Providing you haven't set any other standard nf-core parameters to __cap__ the [maximum resources](https://nf-co.re/usage/configuration#max-resources) used by the pipeline then we can try and bypass the `STAR_ALIGN` process failure by creating a custom config file that sets at least 72GB of memory, in this case increased to 100GB. The custom config below can then be provided to the pipeline via the [`-c`](#-c) parameter as highlighted in previous sections. +To bypass this error you would need to find exactly which resources are set by the `STAR_ALIGN` process. The quickest way is to search for `process STAR_ALIGN` in the [nf-core/rnaseq Github repo](https://github.com/nf-core/rnaseq/search?q=process+STAR_ALIGN). +We have standardised the structure of Nextflow DSL2 pipelines such that all module files will be present in the `modules/` directory and so, based on the search results, the file we want is `modules/nf-core/software/star/align/main.nf`. +If you click on the link to that file you will notice that there is a `label` directive at the top of the module that is set to [`label process_high`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/modules/nf-core/software/star/align/main.nf#L9). +The [Nextflow `label`](https://www.nextflow.io/docs/latest/process.html#label) directive allows us to organise workflow processes in separate groups which can be referenced in a configuration file to select and configure subset of processes having similar computing requirements. +The default values for the `process_high` label are set in the pipeline's [`base.config`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/base.config#L33-L37) which in this case is defined as 72GB. +Providing you haven't set any other standard nf-core parameters to **cap** the [maximum resources](https://nf-co.re/usage/configuration#max-resources) used by the pipeline then we can try and bypass the `STAR_ALIGN` process failure by creating a custom config file that sets at least 72GB of memory, in this case increased to 100GB. +The custom config below can then be provided to the pipeline via the [`-c`](#-c) parameter as highlighted in previous sections. ```nextflow process { - withName: STAR_ALIGN { + withName: 'NFCORE_RNASEQ:RNASEQ:ALIGN_STAR:STAR_ALIGN' { memory = 100.GB } } ``` -> **NB:** We specify just the process name i.e. `STAR_ALIGN` in the config file and not the full task name string that is printed to screen in the error message or on the terminal whilst the pipeline is running i.e. `RNASEQ:ALIGN_STAR:STAR_ALIGN`. You may get a warning suggesting that the process selector isn't recognised but you can ignore that if the process name has been specified correctly. This is something that needs to be fixed upstream in core Nextflow. +> **NB:** We specify the full process name i.e. `NFCORE_RNASEQ:RNASEQ:ALIGN_STAR:STAR_ALIGN` in the config file because this takes priority over the short name (`STAR_ALIGN`) and allows existing configuration using the full process name to be correctly overridden. +> If you get a warning suggesting that the process selector isn't recognised check that the process name has been specified correctly. ### Updating containers diff --git a/lib/NfcoreSchema.groovy b/lib/NfcoreSchema.groovy index 40ab65f20..b3d092f80 100755 --- a/lib/NfcoreSchema.groovy +++ b/lib/NfcoreSchema.groovy @@ -27,7 +27,7 @@ class NfcoreSchema { /* groovylint-disable-next-line UnusedPrivateMethodParameter */ public static void validateParameters(workflow, params, log, schema_filename='nextflow_schema.json') { def has_error = false - //=====================================================================// + //~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~// // Check for nextflow core params and unexpected params def json = new File(getSchemaPath(workflow, schema_filename=schema_filename)).text def Map schemaParams = (Map) new JsonSlurper().parseText(json).get('definitions') @@ -135,7 +135,7 @@ class NfcoreSchema { } } - //=====================================================================// + //~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~// // Validate parameters against the schema InputStream input_stream = new File(getSchemaPath(workflow, schema_filename=schema_filename)).newInputStream() JSONObject raw_schema = new JSONObject(new JSONTokener(input_stream)) diff --git a/lib/Utils.groovy b/lib/Utils.groovy index 1b88aec0e..28567bd70 100755 --- a/lib/Utils.groovy +++ b/lib/Utils.groovy @@ -29,12 +29,12 @@ class Utils { conda_check_failed |= !(channels.indexOf('bioconda') < channels.indexOf('defaults')) if (conda_check_failed) { - log.warn "=============================================================================\n" + + log.warn "~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~\n" + " There is a problem with your Conda configuration!\n\n" + " You will need to set-up the conda-forge and bioconda channels correctly.\n" + " Please refer to https://bioconda.github.io/user/install.html#set-up-channels\n" + " NB: The order of the channels matters!\n" + - "===================================================================================" + "~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~" } } } diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index 4ca6323ae..547194f75 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -48,11 +48,11 @@ class WorkflowChipseq { // private static void genomeExistsError(params, log) { if (params.genomes && params.genome && !params.genomes.containsKey(params.genome)) { - log.error "=============================================================================\n" + + log.error "~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~\n" + " Genome '${params.genome}' not found in any config files provided to the pipeline.\n" + " Currently, the available genome keys are:\n" + " ${params.genomes.keySet().join(", ")}\n" + - "===================================================================================" + "~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~" System.exit(1) } } diff --git a/main.nf b/main.nf index 7a90164a5..cf50b1183 100644 --- a/main.nf +++ b/main.nf @@ -1,8 +1,8 @@ #!/usr/bin/env nextflow /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ nf-core/chipseq -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Github : https://github.com/nf-core/chipseq Website: https://nf-co.re/chipseq Slack : https://nfcore.slack.com/channels/chipseq @@ -12,25 +12,25 @@ nextflow.enable.dsl = 2 /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ GENOME PARAMETER VALUES -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ params.fasta = WorkflowMain.getGenomeAttribute(params, 'fasta') /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ VALIDATE & PRINT PARAMETER SUMMARY -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ WorkflowMain.initialise(workflow, params, log) /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ NAMED WORKFLOW FOR PIPELINE -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ include { CHIPSEQ } from './workflows/chipseq' @@ -43,9 +43,9 @@ workflow NFCORE_CHIPSEQ { } /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ RUN ALL WORKFLOWS -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ // @@ -57,7 +57,7 @@ workflow { } /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ THE END -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ diff --git a/nextflow.config b/nextflow.config index d771f6620..407e69049 100644 --- a/nextflow.config +++ b/nextflow.config @@ -1,7 +1,7 @@ /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ nf-core/chipseq Nextflow config file -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Default config options for all compute environments ---------------------------------------------------------------------------------------- */ @@ -26,6 +26,7 @@ params { // Boilerplate options outdir = './results' tracedir = "${params.outdir}/pipeline_info" + publish_dir_mode = 'copy' email = null email_on_fail = null plaintext_email = false @@ -121,7 +122,7 @@ if (!params.igenomes_ignore) { } // Export these variables to prevent local Python/R libraries from conflicting with those in the container -// The JULIA depot path has been adjusted to a fixed path `/usr/local/share/julia` that needs to be used for packages in the container. +// The JULIA depot path has been adjusted to a fixed path `/usr/local/share/julia` that needs to be used for packages in the container. // See https://apeltzer.github.io/post/03-julia-lang-nextflow/ for details on that. Once we have a common agreement on where to keep Julia packages, this is adjustable. env { diff --git a/nextflow_schema.json b/nextflow_schema.json index 91a37921a..b74007bf8 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -178,6 +178,22 @@ "fa_icon": "fas fa-question-circle", "hidden": true }, + "publish_dir_mode": { + "type": "string", + "default": "copy", + "description": "Method used to save pipeline results to output directory.", + "help_text": "The Nextflow `publishDir` option specifies which intermediate files should be saved to the output directory. This option tells the pipeline what method should be used to move these files. See [Nextflow docs](https://www.nextflow.io/docs/latest/process.html#publishdir) for details.", + "fa_icon": "fas fa-copy", + "enum": [ + "symlink", + "rellink", + "link", + "copy", + "copyNoFollow", + "move" + ], + "hidden": true + }, "email_on_fail": { "type": "string", "description": "Email address for completion summary, only when pipeline fails.", diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 5714aa820..0a51968e9 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -1,7 +1,7 @@ /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ VALIDATE INPUTS -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ def summary_params = NfcoreSchema.paramsSummaryMap(workflow, params) @@ -18,18 +18,18 @@ for (param in checkPathParamList) { if (param) { file(param, checkIfExists: true if (params.input) { ch_input = file(params.input) } else { exit 1, 'Input samplesheet not specified!' } /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ CONFIG FILES -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ ch_multiqc_config = file("$projectDir/assets/multiqc_config.yaml", checkIfExists: true) ch_multiqc_custom_config = params.multiqc_config ? Channel.fromPath(params.multiqc_config) : Channel.empty() /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ IMPORT LOCAL MODULES/SUBWORKFLOWS -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ // @@ -38,9 +38,9 @@ ch_multiqc_custom_config = params.multiqc_config ? Channel.fromPath(params.multi include { INPUT_CHECK } from '../subworkflows/local/input_check' /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ IMPORT NF-CORE MODULES/SUBWORKFLOWS -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ // @@ -51,9 +51,9 @@ include { MULTIQC } from '../modules/nf-core/modules/multiqc include { CUSTOM_DUMPSOFTWAREVERSIONS } from '../modules/nf-core/modules/custom/dumpsoftwareversions/main' /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ RUN MAIN WORKFLOW -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ // Info required for completion email and summary @@ -104,9 +104,9 @@ workflow CHIPSEQ { } /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ COMPLETION EMAIL AND SUMMARY -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ workflow.onComplete { @@ -117,7 +117,7 @@ workflow.onComplete { } /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ THE END -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ From bfc515e083db981285a148a12d57fc39868853dd Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Wed, 2 Mar 2022 17:46:51 +0100 Subject: [PATCH 333/538] Fix YAMLLint in pipeline --- .github/workflows/branch.yml | 1 - .github/workflows/ci.yml | 8 +-- .github/workflows/linting.yml | 1 - .github/workflows/linting_comment.yml | 2 - CHANGELOG.md | 12 ++-- README.md | 8 +-- assets/multiqc_config.yaml | 80 +++++++++++++-------------- 7 files changed, 54 insertions(+), 58 deletions(-) diff --git a/.github/workflows/branch.yml b/.github/workflows/branch.yml index 0615f2af9..df47787a7 100644 --- a/.github/workflows/branch.yml +++ b/.github/workflows/branch.yml @@ -43,4 +43,3 @@ jobs: Thanks again for your contribution! repo-token: ${{ secrets.GITHUB_TOKEN }} allow-repeats: false - diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index b07666f23..a47a74e65 100755 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -53,8 +53,8 @@ jobs: strategy: matrix: parameters: - - "--skip_trimming" - - "--skip_consensus_peaks" + - "--skip_trimming" + - "--skip_consensus_peaks" steps: - name: Check out pipeline code uses: actions/checkout@v2 @@ -75,8 +75,8 @@ jobs: strategy: matrix: aligner: - - "bowtie2" - - "star" + - "bowtie2" + - "star" steps: - name: Check out pipeline code uses: actions/checkout@v2 diff --git a/.github/workflows/linting.yml b/.github/workflows/linting.yml index fda934c03..29088e5bb 100755 --- a/.github/workflows/linting.yml +++ b/.github/workflows/linting.yml @@ -138,4 +138,3 @@ jobs: lint_log.txt lint_results.md PR_number.txt - diff --git a/.github/workflows/linting_comment.yml b/.github/workflows/linting_comment.yml index 44d72994b..04758f61e 100644 --- a/.github/workflows/linting_comment.yml +++ b/.github/workflows/linting_comment.yml @@ -1,4 +1,3 @@ - name: nf-core linting comment # This workflow is triggered after the linting action is complete # It posts an automated comment to the PR, even if the PR is coming from a fork @@ -27,4 +26,3 @@ jobs: GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }} number: ${{ steps.pr_number.outputs.pr_number }} path: linting-logs/lint_results.md - diff --git a/CHANGELOG.md b/CHANGELOG.md index b42ead40f..edff6dcd5 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -33,9 +33,9 @@ via the `--aligner` parameter | | `--save_unaligned` | | `--skip_diff_analysis` | `--skip_deseq2_qc` | -> **NB:** Parameter has been __updated__ if both old and new parameter information is present. -> **NB:** Parameter has been __added__ if just the new parameter information is present. -> **NB:** Parameter has been __removed__ if parameter information isn't present. +> __NB:__ Parameter has been __updated__ if both old and new parameter information is present. +> __NB:__ Parameter has been __added__ if just the new parameter information is present. +> __NB:__ Parameter has been __removed__ if parameter information isn't present. ### Software dependencies @@ -49,9 +49,9 @@ TODO: update all new dependencies | `deeptools` | 3.4.3 | 3.5.1 | | `samtools` | 1.10 | 1.13 | -> **NB:** Dependency has been __updated__ if both old and new version information is present. -> **NB:** Dependency has been __added__ if just the new version information is present. -> **NB:** Dependency has been __removed__ if version information isn't present. +> __NB:__ Dependency has been __updated__ if both old and new version information is present. +> __NB:__ Dependency has been __added__ if just the new version information is present. +> __NB:__ Dependency has been __removed__ if version information isn't present. ## [1.2.2] - 2021-04-22 diff --git a/README.md b/README.md index 54124fd8b..e31aa418b 100644 --- a/README.md +++ b/README.md @@ -37,10 +37,10 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool * reads that are unmapped ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) * reads that map to multiple locations ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) * reads containing > 4 mismatches ([`BAMTools`](https://github.com/pezmaster31/bamtools)) - * reads that have an insert size > 2kb ([`BAMTools`](https://github.com/pezmaster31/bamtools); *paired-end only*) - * reads that map to different chromosomes ([`Pysam`](http://pysam.readthedocs.io/en/latest/installation.html); *paired-end only*) - * reads that arent in FR orientation ([`Pysam`](http://pysam.readthedocs.io/en/latest/installation.html); *paired-end only*) - * reads where only one read of the pair fails the above criteria ([`Pysam`](http://pysam.readthedocs.io/en/latest/installation.html); *paired-end only*) + * reads that have an insert size > 2kb ([`BAMTools`](https://github.com/pezmaster31/bamtools); _paired-end only_) + * reads that map to different chromosomes ([`Pysam`](http://pysam.readthedocs.io/en/latest/installation.html); _paired-end only_) + * reads that arent in FR orientation ([`Pysam`](http://pysam.readthedocs.io/en/latest/installation.html); _paired-end only_) + * reads where only one read of the pair fails the above criteria ([`Pysam`](http://pysam.readthedocs.io/en/latest/installation.html); _paired-end only_) 3. Alignment-level QC and estimation of library complexity ([`picard`](https://broadinstitute.github.io/picard/), [`Preseq`](http://smithlabresearch.org/software/preseq/)) 4. Create normalised bigWig files scaled to 1 million mapped reads ([`BEDTools`](https://github.com/arq5x/bedtools2/), [`bedGraphToBigWig`](http://hgdownload.soe.ucsc.edu/admin/exe/)) 5. Generate gene-body meta-profile from bigWig files ([`deepTools`](https://deeptools.readthedocs.io/en/develop/content/tools/plotProfile.html)) diff --git a/assets/multiqc_config.yaml b/assets/multiqc_config.yaml index 689795628..5d17a2139 100644 --- a/assets/multiqc_config.yaml +++ b/assets/multiqc_config.yaml @@ -21,56 +21,56 @@ exclude_modules: module_order: - fastqc: - name: 'LIB: FastQC (raw)' - info: 'This section of the report shows FastQC results before adapter trimming for individual libraries.' - path_filters: - - './fastqc/*.zip' + name: 'LIB: FastQC (raw)' + info: 'This section of the report shows FastQC results before adapter trimming for individual libraries.' + path_filters: + - './fastqc/*.zip' - cutadapt: - name: 'LIB: cutadapt (trimmed)' - info: 'This section of the report shows the length of trimmed reads by cutadapt for individual libraries.' + name: 'LIB: cutadapt (trimmed)' + info: 'This section of the report shows the length of trimmed reads by cutadapt for individual libraries.' - fastqc: - name: 'LIB: FastQC (trimmed)' - info: 'This section of the report shows FastQC results after adapter trimming for individual libraries.' - path_filters: - - './trimgalore/fastqc/*.zip' + name: 'LIB: FastQC (trimmed)' + info: 'This section of the report shows FastQC results after adapter trimming for individual libraries.' + path_filters: + - './trimgalore/fastqc/*.zip' - samtools: - name: 'LIB: SAMTools' - info: 'This section of the report shows SAMTools results for individual libraries.' - path_filters: - - './alignment/library/*' + name: 'LIB: SAMTools' + info: 'This section of the report shows SAMTools results for individual libraries.' + path_filters: + - './alignment/library/*' - samtools: - name: 'MERGED LIB: SAMTools (unfiltered)' - info: 'This section of the report shows SAMTools results after merging libraries and before filtering.' - path_filters: - - './alignment/mergedLibrary/unfiltered/*.mLb.mkD.sorted.bam*' + name: 'MERGED LIB: SAMTools (unfiltered)' + info: 'This section of the report shows SAMTools results after merging libraries and before filtering.' + path_filters: + - './alignment/mergedLibrary/unfiltered/*.mLb.mkD.sorted.bam*' - picard: - name: 'MERGED LIB: Picard (unfiltered)' - info: 'This section of the report shows picard results after merging libraries and before filtering.' - path_filters: - - './alignment/mergedLibrary/unfiltered/picard_metrics/*' + name: 'MERGED LIB: Picard (unfiltered)' + info: 'This section of the report shows picard results after merging libraries and before filtering.' + path_filters: + - './alignment/mergedLibrary/unfiltered/picard_metrics/*' - preseq: - name: 'MERGED LIB: Preseq (unfiltered)' - info: 'This section of the report shows Preseq results after merging libraries and before filtering.' + name: 'MERGED LIB: Preseq (unfiltered)' + info: 'This section of the report shows Preseq results after merging libraries and before filtering.' - samtools: - name: 'MERGED LIB: SAMTools (filtered)' - info: 'This section of the report shows SAMTools results after merging libraries and after filtering.' - path_filters: - - './alignment/mergedLibrary/filtered/*.mLb.clN.sorted.bam*' + name: 'MERGED LIB: SAMTools (filtered)' + info: 'This section of the report shows SAMTools results after merging libraries and after filtering.' + path_filters: + - './alignment/mergedLibrary/filtered/*.mLb.clN.sorted.bam*' - picard: - name: 'MERGED LIB: Picard (filtered)' - info: 'This section of the report shows picard results after merging libraries and after filtering.' - path_filters: - - './alignment/mergedLibrary/filtered/picard_metrics/*' + name: 'MERGED LIB: Picard (filtered)' + info: 'This section of the report shows picard results after merging libraries and after filtering.' + path_filters: + - './alignment/mergedLibrary/filtered/picard_metrics/*' - deeptools: - name: 'MERGED LIB: deepTools' - anchor: 'mlib_deeptools' - info: 'This section of the report shows ChIP-seq QC plots generated by deepTools.' + name: 'MERGED LIB: deepTools' + anchor: 'mlib_deeptools' + info: 'This section of the report shows ChIP-seq QC plots generated by deepTools.' - featureCounts: - name: 'MERGED LIB: featureCounts' - anchor: 'mlib_featurecounts' - info: 'This section of the report shows featureCounts results for the number of reads assigned to merged library consensus peaks.' - path_filters: - - './macs/consensus/*.summary' + name: 'MERGED LIB: featureCounts' + anchor: 'mlib_featurecounts' + info: 'This section of the report shows featureCounts results for the number of reads assigned to merged library consensus peaks.' + path_filters: + - './macs/consensus/*.summary' report_section_order: peak_count: From 755cc3223145e60a41f483c9f5e3e255a3ddad7c Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Wed, 2 Mar 2022 17:50:38 +0100 Subject: [PATCH 334/538] Fix nf-core linting --- .nf-core.yml | 7 ++++++- CHANGELOG.md | 2 +- 2 files changed, 7 insertions(+), 2 deletions(-) diff --git a/.nf-core.yml b/.nf-core.yml index 966dc6f35..aca9e11fa 100644 --- a/.nf-core.yml +++ b/.nf-core.yml @@ -3,7 +3,12 @@ lint: - .markdownlint.yml - assets/email_template.html - assets/email_template.txt - - lib/NfcoreTemplate.groovy - assets/multiqc_config.yaml + - lib/NfcoreTemplate.groovy + - lib/NfcoreSchema.groovy + - .github/ISSUE_TEMPLATE/bug_report.yml + - .github/workflows/branch.yml + - .github/workflows/linting_comment.yml + - .github/workflows/linting.yml repository_type: pipeline diff --git a/CHANGELOG.md b/CHANGELOG.md index edff6dcd5..98b5d4b01 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -156,7 +156,7 @@ TODO: update all new dependencies ### `Fixed` -* **Change all parameters from `camelCase` to `snake_case` (see [Deprecated](#Deprecated))** +* Change all parameters from `camelCase` to `snake_case` (see [Deprecated](#Deprecated)) * [nf-core/atacseq#44](https://github.com/nf-core/atacseq/issues/44) - Output directory missing: macs2/consensus/deseq2 * [nf-core/atacseq#45](https://github.com/nf-core/atacseq/issues/45) - Wrong x-axis scale for the HOMER: Peak annotation Counts tab plot? * [nf-core/atacseq#46](https://github.com/nf-core/atacseq/issues/46) - Stage blacklist file in channel properly From 4bb1c93e6a91200b2ab612455751fc5c1506030d Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 3 Mar 2022 11:19:32 +0100 Subject: [PATCH 335/538] Reformat chr ids from mm10 to GRCm38 --- .../blacklists/v2.0/GRCm38-blacklist.v2.bed | 3435 +++++++++++++++++ 1 file changed, 3435 insertions(+) create mode 100644 assets/blacklists/v2.0/GRCm38-blacklist.v2.bed diff --git a/assets/blacklists/v2.0/GRCm38-blacklist.v2.bed b/assets/blacklists/v2.0/GRCm38-blacklist.v2.bed new file mode 100644 index 000000000..41007eb72 --- /dev/null +++ b/assets/blacklists/v2.0/GRCm38-blacklist.v2.bed @@ -0,0 +1,3435 @@ +10 0 3135400 High Signal Region +10 3218900 3276600 Low Mappability +10 3576900 3627700 Low Mappability +10 4191100 4197600 Low Mappability +10 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High Signal Region +Y 2017200 2068000 Low Mappability +Y 2104700 2210800 High Signal Region +Y 2280300 2288900 Low Mappability +Y 2471300 3819300 High Signal Region +Y 3880300 4177100 High Signal Region +Y 4249500 4289100 High Signal Region +Y 4432000 4956300 High Signal Region +Y 5062400 5227700 High Signal Region +Y 6376700 6382700 High Signal Region +Y 6530200 6663200 High Signal Region +Y 6760200 6835800 High Signal Region +Y 6984100 8985400 High Signal Region +Y 10638500 41003800 High Signal Region +Y 41159200 91744600 High Signal Region From 99651001813a5c3e6a4aac01793d0e9f67010397 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 3 Mar 2022 17:32:56 +0100 Subject: [PATCH 336/538] Reformat v3 blacklist from hg38 to GRCh38 --- .../blacklists/v3.0/GRCh38-blacklist.v3.bed | 910 ++++++++++++++++++ 1 file changed, 910 insertions(+) create mode 100644 assets/blacklists/v3.0/GRCh38-blacklist.v3.bed diff --git a/assets/blacklists/v3.0/GRCh38-blacklist.v3.bed 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10663716 +Y 10744417 10921497 +Y 11290797 11334278 +Y 11493053 11592850 +Y 11671014 11671046 +Y 11721528 11749472 +Y 56694632 56889743 From 1b431aebbdf3bc4d2b399cbdf6d9900987eb08a6 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 3 Mar 2022 18:08:31 +0100 Subject: [PATCH 337/538] Keep the manual annotated blacklist files --- .../blacklists/v1.0/GRCm38-blacklist.v1.bed | 164 ++++++++++++++++++ assets/blacklists/v1.0/mm10-blacklist.v1.bed | 164 ++++++++++++++++++ mm10-blacklist.bed | 164 ++++++++++++++++++ 3 files changed, 492 insertions(+) create mode 100755 assets/blacklists/v1.0/GRCm38-blacklist.v1.bed create mode 100755 assets/blacklists/v1.0/mm10-blacklist.v1.bed create mode 100755 mm10-blacklist.bed diff --git a/assets/blacklists/v1.0/GRCm38-blacklist.v1.bed b/assets/blacklists/v1.0/GRCm38-blacklist.v1.bed new file mode 100755 index 000000000..3699d020a --- /dev/null +++ b/assets/blacklists/v1.0/GRCm38-blacklist.v1.bed @@ -0,0 +1,164 @@ +10 3110060 3110270 +10 22142530 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3018650 3018870 +chr9 3019220 3019450 +chr9 3021160 3021370 +chr9 3021990 3022300 +chr9 3024660 3024880 +chr9 3025350 3025690 +chr9 3026530 3026860 +chr9 3027010 3027250 +chr9 3027660 3027880 +chr9 3028670 3028880 +chr9 3030040 3030330 +chr9 3031910 3032130 +chr9 3032250 3032560 +chr9 3032570 3032790 +chr9 3034090 3034300 +chr9 3034950 3035160 +chr9 3035610 3036180 +chr9 3036200 3036480 +chr9 3036420 3036660 +chr9 3037250 3037460 +chr9 3037910 3038120 +chr9 3038050 3038300 +chr9 24541940 24542200 +chr9 35305120 35305620 +chr9 110281190 110281400 +chr9 123872950 123873160 diff --git a/mm10-blacklist.bed b/mm10-blacklist.bed new file mode 100755 index 000000000..8c71cd3ba --- /dev/null +++ b/mm10-blacklist.bed @@ -0,0 +1,164 @@ +chr10 3110060 3110270 +chr10 22142530 22142880 +chr10 22142830 22143070 +chr10 58223870 58224100 +chr10 58225260 58225500 +chr10 58228320 58228520 +chr11 3148660 3148860 +chr11 3154960 3155170 +chr11 3158530 3158750 +chr11 3161780 3161990 +chr11 3167020 3167250 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47454330 47454510 +chr15 75085430 75085920 +chr15 75085990 75086240 +chr15 75086150 75086550 +chr15 75086540 75087110 +chr16 11143960 11144170 +chr16 57391420 57391740 +chr17 13305860 13306280 +chr17 13590820 13591650 +chr17 13654880 13655120 +chr17 36231170 36231390 +chr17 39842910 39846780 +chr17 39846920 39847160 +chr17 39847090 39847310 +chr17 39847400 39847720 +chr17 39847630 39848880 +chr18 3005550 3005770 +chr18 3005700 3006050 +chr18 12949190 12949400 +chr18 40307970 40308340 +chr18 68691990 68692230 +chr19 45650030 45650310 +chr19 61199640 61199880 +chr19 61224310 61224530 +chr19 61266550 61266760 +chr19 61266920 61267210 +chr1 24612620 24612850 +chr1 48881430 48881690 +chr1 58613870 58614090 +chr1 78573920 78574140 +chr1 88217960 88221950 +chr1 88223300 88224760 +chr1 133595120 133595340 +chr1 183299040 183299660 +chr1 195241610 195241820 +chr2 3050030 3050410 +chr2 5379200 5379420 +chr2 22743580 22743780 +chr2 22744760 22744980 +chr2 90395030 90395240 +chr2 98662130 98663060 +chr2 98663540 98664150 +chr2 98664780 98665020 +chr2 98664970 98665250 +chr2 98666140 98667390 +chr2 181917260 181917590 +chr2 181917550 181917990 +chr2 181918970 181919260 +chr2 181928340 181928570 +chr2 181928950 181929170 +chr2 181929220 181929430 +chr2 181930800 181931020 +chr3 5860530 5860830 +chr3 8245690 8245930 +chr3 8246280 8246640 +chr4 34935690 34935910 +chr4 70378040 70378320 +chr4 118548460 118548700 +chr5 14914900 14915120 +chr5 15006590 15006820 +chr5 15462500 15462730 +chr5 15463060 15463290 +chr5 15486990 15487190 +chr5 134378920 134379160 +chr5 137152130 137152510 +chr5 146260900 146261410 +chr6 3201380 3201610 +chr6 103648970 103649310 +chr7 12010340 12010870 +chr8 14306800 14307040 +chr8 15519790 15520030 +chr8 19711890 19712070 +chr9 2999900 3000320 +chr9 3000270 3000570 +chr9 3000900 3001100 +chr9 3001300 3001520 +chr9 3004390 3004680 +chr9 3004690 3004900 +chr9 3005000 3005220 +chr9 3005800 3006030 +chr9 3006960 3007180 +chr9 3008880 3009040 +chr9 3015170 3015420 +chr9 3015590 3015830 +chr9 3016770 3016980 +chr9 3017410 3017650 +chr9 3018240 3018540 +chr9 3018650 3018870 +chr9 3019220 3019450 +chr9 3021160 3021370 +chr9 3021990 3022300 +chr9 3024660 3024880 +chr9 3025350 3025690 +chr9 3026530 3026860 +chr9 3027010 3027250 +chr9 3027660 3027880 +chr9 3028670 3028880 +chr9 3030040 3030330 +chr9 3031910 3032130 +chr9 3032250 3032560 +chr9 3032570 3032790 +chr9 3034090 3034300 +chr9 3034950 3035160 +chr9 3035610 3036180 +chr9 3036200 3036480 +chr9 3036420 3036660 +chr9 3037250 3037460 +chr9 3037910 3038120 +chr9 3038050 3038300 +chr9 24541940 24542200 +chr9 35305120 35305620 +chr9 110281190 110281400 +chr9 123872950 123873160 From 30d0d68f6851bb110967eeb79a14280ca215cae5 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 3 Mar 2022 18:09:00 +0100 Subject: [PATCH 338/538] Update igenomes with the new or reallocated blacklist files --- conf/igenomes.config | 12 ++++++------ 1 file changed, 6 insertions(+), 6 deletions(-) diff --git a/conf/igenomes.config b/conf/igenomes.config index 7a1b3ac6d..1665112d5 100644 --- a/conf/igenomes.config +++ b/conf/igenomes.config @@ -22,7 +22,7 @@ params { readme = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/README.txt" mito_name = "MT" macs_gsize = "2.7e9" - blacklist = "${projectDir}/assets/blacklists/GRCh37-blacklist.bed" + blacklist = "${projectDir}/assets/blacklists/v1.0/GRCh37-blacklist.v1.bed" } 'GRCh38' { fasta = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/WholeGenomeFasta/genome.fa" @@ -34,7 +34,7 @@ params { bed12 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Annotation/Genes/genes.bed" mito_name = "chrM" macs_gsize = "2.7e9" - blacklist = "${projectDir}/assets/blacklists/hg38-blacklist.bed" + blacklist = "${projectDir}/assets/blacklists/v3.0/hg38-blacklist.v3.bed" } 'GRCm38' { fasta = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/WholeGenomeFasta/genome.fa" @@ -47,7 +47,7 @@ params { readme = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/README.txt" mito_name = "MT" macs_gsize = "1.87e9" - blacklist = "${projectDir}/assets/blacklists/GRCm38-blacklist.bed" + blacklist = "${projectDir}/assets/blacklists/v1.0/GRCm38-blacklist.v1.bed" } 'TAIR10' { fasta = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/WholeGenomeFasta/genome.fa" @@ -281,7 +281,7 @@ params { bed12 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Annotation/Genes/genes.bed" mito_name = "chrM" macs_gsize = "2.7e9" - blacklist = "${projectDir}/assets/blacklists/hg38-blacklist.bed" + blacklist = "${projectDir}/assets/blacklists/v3.0/hg38-blacklist.v3.bed" } 'hg19' { fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/WholeGenomeFasta/genome.fa" @@ -294,7 +294,7 @@ params { readme = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/README.txt" mito_name = "chrM" macs_gsize = "2.7e9" - blacklist = "${projectDir}/assets/blacklists/hg19-blacklist.bed" + blacklist = "${projectDir}/assets/blacklists/v1.0/hg19-blacklist.v1.bed" } 'mm10' { fasta = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/WholeGenomeFasta/genome.fa" @@ -307,7 +307,7 @@ params { readme = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/README.txt" mito_name = "chrM" macs_gsize = "1.87e9" - blacklist = "${projectDir}/assets/blacklists/mm10-blacklist.bed" + blacklist = "${projectDir}/assets/blacklists/v1.0/mm10-blacklist.v1.bed" } 'bosTau8' { fasta = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/WholeGenomeFasta/genome.fa" From c2094808c50f35609c31818ed310ec2dca0d0c70 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 3 Mar 2022 18:09:17 +0100 Subject: [PATCH 339/538] Update changelog --- CHANGELOG.md | 30 +++++++++++++++++++++++------- 1 file changed, 23 insertions(+), 7 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 98b5d4b01..8e496fce5 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -12,14 +12,14 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 * Bump minimum Nextflow version from `21.04.0` -> `21.10.3` * Updated pipeline template to [nf-core/tools 2.2](https://github.com/nf-core/tools/releases/tag/2.2) * Added `python3` shebang to appropriate scripts in `bin/` directory -* [[#160](https://github.com/nf-core/chipseq/issues/160)] - Add `bowtie2` and `star` as available aligners, -via the `--aligner` parameter +* [[#160](https://github.com/nf-core/chipseq/issues/160)] - Add `bowtie2` and `star` as available aligners, via the `--aligner` parameter ### Other enhancements & fixes * Update pipeline template to nf-core/tools `2.1` * Add `--save_unaligned` parameter (only available for `bowtie2` and `star`) * Update `igenomes.config` to fetch whole `BWAIndex/version0.6.0/` folder +* [[228](https://github.com/nf-core/chipseq/issues/228)] - Update blacklist bed files. ### Parameters @@ -27,7 +27,6 @@ via the `--aligner` parameter |------------------------------|----------------------------| | `--clusterOptions` | | | `--conda` | `--enable_conda` | -| `--single_end` | | | | `--skip_qc` | | | `--aligner` | | | `--save_unaligned` | @@ -43,12 +42,29 @@ Note, since the pipeline is now using Nextflow DSL2, each process will be run wi -| Dependency | Old version | New version | -|-------------|-------------|-------------| -| `deeptools` | 3.4.3 | 3.5.1 | + +| Dependency | Old version | New version | +|---------------|-------------|-------------| +| `` | | | +| `` | | | +| `` | | | +| `` | | | +| `deeptools` | 3.4.3 | 3.5.1 | +| `fastqc` | | 0.11.9 | +| `` | | | +| `trim-galore` | | | +| `samtools` | | | +| `` | | | +| `` | | | +| `` | | | +| `` | | | +| `` | | | + +| `multiqc` | 1.10 | 1.13 | | `samtools` | 1.10 | 1.13 | +--> + > __NB:__ Dependency has been __updated__ if both old and new version information is present. > __NB:__ Dependency has been __added__ if just the new version information is present. > __NB:__ Dependency has been __removed__ if version information isn't present. From 7bac1def45c6fa98b21cd561f49396c37c477948 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 3 Mar 2022 18:11:05 +0100 Subject: [PATCH 340/538] Add again the logic for using blacklist bed files --- subworkflows/local/prepare_genome.nf | 7 ++++++- 1 file changed, 6 insertions(+), 1 deletion(-) diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index 3c3df3e90..a88d05725 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -34,6 +34,7 @@ workflow PREPARE_GENOME { // // Uncompress genome fasta file if required // + ch_fasta = Channel.empty() if (params.fasta.endsWith('.gz')) { ch_fasta = GUNZIP_FASTA ( params.fasta ).gunzip ch_versions = ch_versions.mix(GUNZIP_FASTA.out.versions) @@ -111,12 +112,16 @@ workflow PREPARE_GENOME { // // Prepare genome intervals for filtering by removing regions in blacklist file // + ch_genome_filtered_bed = Channel.empty() + GENOME_BLACKLIST_REGIONS ( CUSTOM_GETCHROMSIZES.out.sizes, ch_blacklist.ifEmpty([]) ) + ch_genome_filtered_bed = GENOME_BLACKLIST_REGIONS.out.bed ch_versions = ch_versions.mix(GENOME_BLACKLIST_REGIONS.out.versions) + // // Uncompress BWA index or generate from scratch if required // @@ -176,7 +181,7 @@ workflow PREPARE_GENOME { gtf = ch_gtf // path: genome.gtf gene_bed = ch_gene_bed // path: gene.bed chrom_sizes = ch_chrom_sizes // path: genome.sizes - blacklist = ch_blacklist // path: blacklist.bed + filtered_bed = ch_genome_filtered_bed // path: *.include_regions.bed bwa_index = ch_bwa_index // path: bwa/index/ bowtie2_index = ch_bowtie2_index // path: bowtie2/index/ star_index = ch_star_index // path: star/index/ From 936d3a8095424bde55c85c46051ab0610bae9080 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 3 Mar 2022 18:36:36 +0100 Subject: [PATCH 341/538] Remove v1 bed files from mouse --- .../blacklists/v1.0/GRCm38-blacklist.v1.bed | 164 ------------------ assets/blacklists/v1.0/mm10-blacklist.v1.bed | 164 ------------------ conf/igenomes.config | 4 +- 3 files changed, 2 insertions(+), 330 deletions(-) delete mode 100755 assets/blacklists/v1.0/GRCm38-blacklist.v1.bed delete mode 100755 assets/blacklists/v1.0/mm10-blacklist.v1.bed diff --git a/assets/blacklists/v1.0/GRCm38-blacklist.v1.bed b/assets/blacklists/v1.0/GRCm38-blacklist.v1.bed deleted file mode 100755 index 3699d020a..000000000 --- a/assets/blacklists/v1.0/GRCm38-blacklist.v1.bed +++ /dev/null @@ -1,164 +0,0 @@ -10 3110060 3110270 -10 22142530 22142880 -10 22142830 22143070 -10 58223870 58224100 -10 58225260 58225500 -10 58228320 58228520 -11 3148660 3148860 -11 3154960 3155170 -11 3158530 3158750 -11 3161780 3161990 -11 3167020 3167250 -11 3169390 3169620 -11 3172450 3172670 -11 3172950 3173190 -11 3184190 3185750 -11 3185700 3186360 -11 3186330 3189230 -11 3189190 3190740 -11 3190750 3191000 -11 3190960 3194430 -11 3194400 3195310 -11 3195240 3197220 -11 3197340 3197950 -11 3197890 3198700 -11 3198630 3199440 -11 3199350 3200120 -11 54139940 54140230 -11 54140470 54140740 -11 88967720 88969600 -11 88969850 88970350 -11 109011550 109012090 -12 3109920 3110150 -12 105436040 105436270 -13 3372960 3373380 -13 3373410 3373630 -13 77438870 77439090 -13 97190460 97190690 -13 99790830 99791090 -13 119488570 119489320 -13 119597600 119598320 -13 119599860 119600050 -13 119601360 119601600 -13 119601800 119602210 -13 119602360 119602580 -13 119609430 119611430 -13 119612760 119613370 -13 119613360 119617690 -14 19415650 19417330 -14 19417240 19417660 -14 19417570 19418920 -14 19418830 19419720 -14 47454330 47454510 -15 75085430 75085920 -15 75085990 75086240 -15 75086150 75086550 -15 75086540 75087110 -16 11143960 11144170 -16 57391420 57391740 -17 13305860 13306280 -17 13590820 13591650 -17 13654880 13655120 -17 36231170 36231390 -17 39842910 39846780 -17 39846920 39847160 -17 39847090 39847310 -17 39847400 39847720 -17 39847630 39848880 -18 3005550 3005770 -18 3005700 3006050 -18 12949190 12949400 -18 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b/assets/blacklists/v1.0/mm10-blacklist.v1.bed deleted file mode 100755 index 8c71cd3ba..000000000 --- a/assets/blacklists/v1.0/mm10-blacklist.v1.bed +++ /dev/null @@ -1,164 +0,0 @@ -chr10 3110060 3110270 -chr10 22142530 22142880 -chr10 22142830 22143070 -chr10 58223870 58224100 -chr10 58225260 58225500 -chr10 58228320 58228520 -chr11 3148660 3148860 -chr11 3154960 3155170 -chr11 3158530 3158750 -chr11 3161780 3161990 -chr11 3167020 3167250 -chr11 3169390 3169620 -chr11 3172450 3172670 -chr11 3172950 3173190 -chr11 3184190 3185750 -chr11 3185700 3186360 -chr11 3186330 3189230 -chr11 3189190 3190740 -chr11 3190750 3191000 -chr11 3190960 3194430 -chr11 3194400 3195310 -chr11 3195240 3197220 -chr11 3197340 3197950 -chr11 3197890 3198700 -chr11 3198630 3199440 -chr11 3199350 3200120 -chr11 54139940 54140230 -chr11 54140470 54140740 -chr11 88967720 88969600 -chr11 88969850 88970350 -chr11 109011550 109012090 -chr12 3109920 3110150 -chr12 105436040 105436270 -chr13 3372960 3373380 -chr13 3373410 3373630 -chr13 77438870 77439090 -chr13 97190460 97190690 -chr13 99790830 99791090 -chr13 119488570 119489320 -chr13 119597600 119598320 -chr13 119599860 119600050 -chr13 119601360 119601600 -chr13 119601800 119602210 -chr13 119602360 119602580 -chr13 119609430 119611430 -chr13 119612760 119613370 -chr13 119613360 119617690 -chr14 19415650 19417330 -chr14 19417240 19417660 -chr14 19417570 19418920 -chr14 19418830 19419720 -chr14 47454330 47454510 -chr15 75085430 75085920 -chr15 75085990 75086240 -chr15 75086150 75086550 -chr15 75086540 75087110 -chr16 11143960 11144170 -chr16 57391420 57391740 -chr17 13305860 13306280 -chr17 13590820 13591650 -chr17 13654880 13655120 -chr17 36231170 36231390 -chr17 39842910 39846780 -chr17 39846920 39847160 -chr17 39847090 39847310 -chr17 39847400 39847720 -chr17 39847630 39848880 -chr18 3005550 3005770 -chr18 3005700 3006050 -chr18 12949190 12949400 -chr18 40307970 40308340 -chr18 68691990 68692230 -chr19 45650030 45650310 -chr19 61199640 61199880 -chr19 61224310 61224530 -chr19 61266550 61266760 -chr19 61266920 61267210 -chr1 24612620 24612850 -chr1 48881430 48881690 -chr1 58613870 58614090 -chr1 78573920 78574140 -chr1 88217960 88221950 -chr1 88223300 88224760 -chr1 133595120 133595340 -chr1 183299040 183299660 -chr1 195241610 195241820 -chr2 3050030 3050410 -chr2 5379200 5379420 -chr2 22743580 22743780 -chr2 22744760 22744980 -chr2 90395030 90395240 -chr2 98662130 98663060 -chr2 98663540 98664150 -chr2 98664780 98665020 -chr2 98664970 98665250 -chr2 98666140 98667390 -chr2 181917260 181917590 -chr2 181917550 181917990 -chr2 181918970 181919260 -chr2 181928340 181928570 -chr2 181928950 181929170 -chr2 181929220 181929430 -chr2 181930800 181931020 -chr3 5860530 5860830 -chr3 8245690 8245930 -chr3 8246280 8246640 -chr4 34935690 34935910 -chr4 70378040 70378320 -chr4 118548460 118548700 -chr5 14914900 14915120 -chr5 15006590 15006820 -chr5 15462500 15462730 -chr5 15463060 15463290 -chr5 15486990 15487190 -chr5 134378920 134379160 -chr5 137152130 137152510 -chr5 146260900 146261410 -chr6 3201380 3201610 -chr6 103648970 103649310 -chr7 12010340 12010870 -chr8 14306800 14307040 -chr8 15519790 15520030 -chr8 19711890 19712070 -chr9 2999900 3000320 -chr9 3000270 3000570 -chr9 3000900 3001100 -chr9 3001300 3001520 -chr9 3004390 3004680 -chr9 3004690 3004900 -chr9 3005000 3005220 -chr9 3005800 3006030 -chr9 3006960 3007180 -chr9 3008880 3009040 -chr9 3015170 3015420 -chr9 3015590 3015830 -chr9 3016770 3016980 -chr9 3017410 3017650 -chr9 3018240 3018540 -chr9 3018650 3018870 -chr9 3019220 3019450 -chr9 3021160 3021370 -chr9 3021990 3022300 -chr9 3024660 3024880 -chr9 3025350 3025690 -chr9 3026530 3026860 -chr9 3027010 3027250 -chr9 3027660 3027880 -chr9 3028670 3028880 -chr9 3030040 3030330 -chr9 3031910 3032130 -chr9 3032250 3032560 -chr9 3032570 3032790 -chr9 3034090 3034300 -chr9 3034950 3035160 -chr9 3035610 3036180 -chr9 3036200 3036480 -chr9 3036420 3036660 -chr9 3037250 3037460 -chr9 3037910 3038120 -chr9 3038050 3038300 -chr9 24541940 24542200 -chr9 35305120 35305620 -chr9 110281190 110281400 -chr9 123872950 123873160 diff --git a/conf/igenomes.config b/conf/igenomes.config index 1665112d5..d174cd316 100644 --- a/conf/igenomes.config +++ b/conf/igenomes.config @@ -47,7 +47,7 @@ params { readme = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/README.txt" mito_name = "MT" macs_gsize = "1.87e9" - blacklist = "${projectDir}/assets/blacklists/v1.0/GRCm38-blacklist.v1.bed" + blacklist = "${projectDir}/assets/blacklists/v2.0/GRCm38-blacklist.v2.bed" } 'TAIR10' { fasta = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/WholeGenomeFasta/genome.fa" @@ -307,7 +307,7 @@ params { readme = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/README.txt" mito_name = "chrM" macs_gsize = "1.87e9" - blacklist = "${projectDir}/assets/blacklists/v1.0/mm10-blacklist.v1.bed" + blacklist = "${projectDir}/assets/blacklists/v2.0/mm10-blacklist.v2.bed" } 'bosTau8' { fasta = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/WholeGenomeFasta/genome.fa" From 649d5871c320b44752880d40ae780464d68df685 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 3 Mar 2022 18:43:49 +0100 Subject: [PATCH 342/538] Update usage with the references to the blacklist files --- docs/usage.md | 31 +++++++++++++++++++++++++++++++ 1 file changed, 31 insertions(+) diff --git a/docs/usage.md b/docs/usage.md index f646f779b..c866700b1 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -84,6 +84,37 @@ The minimum reference genome requirements are a FASTA and GTF file, all other fi > **NB:** Compressed reference files are also supported by the pipeline i.e. standard files with the `.gz` extension and indices folders with the `tar.gz` extension. +## Blacklist bed files + +The blacklist bed files where obtained using the commands below: + +``` +cd .. +mkdir -p v1.0 +cd v1.0 +wget -L https://www.encodeproject.org/files/ENCFF001TDO/@@download/ENCFF001TDO.bed.gz && gunzip ENCFF001TDO.bed.gz && mv ENCFF001TDO.bed hg19-blacklist.v1.bed + +mkdir -p assets/blacklists/v2.0/ +cd assets/blacklists/v2.0/ +wget -L https://raw.githubusercontent.com/Boyle-Lab/Blacklist/master/lists/ce10-blacklist.v2.bed.gz && gunzip ce10-blacklist.v2.bed.gz +wget -L https://raw.githubusercontent.com/Boyle-Lab/Blacklist/master/lists/ce11-blacklist.v2.bed.gz && gunzip ce11-blacklist.v2.bed.gz +wget -L https://raw.githubusercontent.com/Boyle-Lab/Blacklist/master/lists/dm3-blacklist.v2.bed.gz && gunzip dm3-blacklist.v2.bed.gz +wget -L https://raw.githubusercontent.com/Boyle-Lab/Blacklist/master/lists/dm6-blacklist.v2.bed.gz && gunzip dm6-blacklist.v2.bed.gz +wget -L https://raw.githubusercontent.com/Boyle-Lab/Blacklist/master/lists/hg19-blacklist.v2.bed.gz && gunzip hg19-blacklist.v2.bed.gz +wget -L https://raw.githubusercontent.com/Boyle-Lab/Blacklist/master/lists/hg38-blacklist.v2.bed.gz && gunzip hg38-blacklist.v2.bed.gz +wget -L https://raw.githubusercontent.com/Boyle-Lab/Blacklist/master/lists/mm10-blacklist.v2.bed.gz && gunzip mm10-blacklist.v2.bed.gz + +cd .. +mkdir -p v3.0 +cd v3.0 +wget -L https://www.encodeproject.org/files/ENCFF356LFX/@@download/ENCFF356LFX.bed.gz && gunzip ENCFF356LFX.bed.gz && mv ENCFF356LFX.bed hg38-blacklist.v3.bed +``` + +> **NB:** A detailed description of the different versions of the files can be found [here](https://sites.google.com/site/anshulkundaje/projects/blacklists) + + +> **NB:** Check the [igenomes.config](https://github.com/nf-core/chipseq/blob/master/conf/igenomes.config) to see which blacklist bed files are assigned by default to the respective reference genome. + ## Running the pipeline The typical command for running the pipeline is as follows: From e417d3ebb73ad359efebccca81167f660085d699 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 3 Mar 2022 18:46:27 +0100 Subject: [PATCH 343/538] Add the blacklist file to filter_bam_bamtools subworkflow --- workflows/chipseq.nf | 13 +++++++++---- 1 file changed, 9 insertions(+), 4 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 5352f73a6..f0e801c4d 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -161,10 +161,8 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(FASTQC_TRIMGALORE.out.versions) - - // - // SUBWORKFLOW: Map reads & BAM QC + // SUBWORKFLOW: Alignment with BWA & BAM QC // ch_genome_bam = Channel.empty() ch_genome_bam_index = Channel.empty() @@ -184,6 +182,9 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(ALIGN_BWA_MEM.out.versions.first()) } + // + // SUBWORKFLOW: Alignment with BOWTIE2 & BAM QC + // if (params.aligner == 'bowtie2') { ALIGN_BOWTIE2 ( FASTQC_TRIMGALORE.out.reads, @@ -198,6 +199,9 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(ALIGN_BOWTIE2.out.versions.first()) } + // + // SUBWORKFLOW: Alignment with STAR & BAM QC + // if (params.aligner == 'star') { ALIGN_STAR ( FASTQC_TRIMGALORE.out.reads, @@ -245,7 +249,8 @@ workflow CHIPSEQ { // FILTER_BAM_BAMTOOLS ( MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), - PREPARE_GENOME.out.blacklist.ifEmpty([]).first(), + PREPARE_GENOME.out.filtered_bed, + ch_bamtools_filter_se_config, ch_bamtools_filter_pe_config ) From 7307d9872d4cb8b51defe0a4435ff7ccec7e9cea Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 3 Mar 2022 18:51:54 +0100 Subject: [PATCH 344/538] Make markdown lint happy again --- docs/usage.md | 7 ++----- 1 file changed, 2 insertions(+), 5 deletions(-) diff --git a/docs/usage.md b/docs/usage.md index c866700b1..89423dc36 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -88,7 +88,7 @@ The minimum reference genome requirements are a FASTA and GTF file, all other fi The blacklist bed files where obtained using the commands below: -``` +```console cd .. mkdir -p v1.0 cd v1.0 @@ -110,10 +110,7 @@ cd v3.0 wget -L https://www.encodeproject.org/files/ENCFF356LFX/@@download/ENCFF356LFX.bed.gz && gunzip ENCFF356LFX.bed.gz && mv ENCFF356LFX.bed hg38-blacklist.v3.bed ``` -> **NB:** A detailed description of the different versions of the files can be found [here](https://sites.google.com/site/anshulkundaje/projects/blacklists) - - -> **NB:** Check the [igenomes.config](https://github.com/nf-core/chipseq/blob/master/conf/igenomes.config) to see which blacklist bed files are assigned by default to the respective reference genome. +> **NB:** A detailed description of the different versions of the files can be found [here](https://sites.google.com/site/anshulkundaje/projects/blacklists). Also, to to see which blacklist bed files are assigned by default to the respective reference genome check the [igenomes.config](https://github.com/nf-core/chipseq/blob/master/conf/igenomes.config). ## Running the pipeline From 98eaca67308c83c520388f8c8dc358d494a5db53 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Sat, 5 Mar 2022 22:24:01 +0100 Subject: [PATCH 345/538] Update modules and small fixes due to update --- conf/modules.config | 2 +- modules.json | 60 +++++----- modules/nf-core/modules/bowtie2/align/main.nf | 3 + .../nf-core/modules/bowtie2/align/meta.yml | 88 +++++++-------- modules/nf-core/modules/bowtie2/build/main.nf | 3 + .../nf-core/modules/bowtie2/build/meta.yml | 52 ++++----- modules/nf-core/modules/bwa/index/main.nf | 3 + modules/nf-core/modules/bwa/index/meta.yml | 50 ++++----- modules/nf-core/modules/bwa/mem/main.nf | 13 ++- modules/nf-core/modules/bwa/mem/meta.yml | 82 +++++++------- .../custom/dumpsoftwareversions/main.nf | 3 + .../custom/dumpsoftwareversions/meta.yml | 2 +- .../modules/custom/getchromsizes/main.nf | 9 +- .../modules/custom/getchromsizes/meta.yml | 3 +- .../modules/deeptools/computematrix/main.nf | 3 + .../modules/deeptools/computematrix/meta.yml | 2 +- .../modules/deeptools/plotfingerprint/main.nf | 3 + .../deeptools/plotfingerprint/meta.yml | 2 +- .../modules/deeptools/plotheatmap/main.nf | 3 + .../modules/deeptools/plotheatmap/meta.yml | 2 +- .../modules/deeptools/plotprofile/main.nf | 3 + .../modules/deeptools/plotprofile/meta.yml | 2 +- modules/nf-core/modules/fastqc/main.nf | 3 + modules/nf-core/modules/fastqc/meta.yml | 90 +++++++-------- modules/nf-core/modules/gffread/main.nf | 7 +- modules/nf-core/modules/gffread/meta.yml | 8 +- modules/nf-core/modules/gunzip/main.nf | 3 + modules/nf-core/modules/gunzip/meta.yml | 54 ++++----- .../modules/homer/annotatepeaks/main.nf | 3 + .../modules/homer/annotatepeaks/meta.yml | 2 +- .../nf-core/modules/macs2/callpeak/main.nf | 3 + .../nf-core/modules/macs2/callpeak/meta.yml | 13 ++- modules/nf-core/modules/multiqc/main.nf | 9 +- modules/nf-core/modules/multiqc/meta.yml | 66 +++++------ .../modules/phantompeakqualtools/main.nf | 3 + .../picard/collectmultiplemetrics/main.nf | 9 +- .../picard/collectmultiplemetrics/meta.yml | 86 +++++++-------- .../modules/picard/markduplicates/main.nf | 9 +- .../modules/picard/markduplicates/meta.yml | 2 +- .../modules/picard/mergesamfiles/main.nf | 9 +- .../modules/picard/mergesamfiles/meta.yml | 68 ++++++------ .../nf-core/modules/preseq/lcextrap/main.nf | 3 + .../nf-core/modules/preseq/lcextrap/meta.yml | 2 +- .../nf-core/modules/samtools/flagstat/main.nf | 16 ++- .../modules/samtools/flagstat/meta.yml | 84 +++++++------- .../nf-core/modules/samtools/idxstats/main.nf | 15 ++- .../modules/samtools/idxstats/meta.yml | 86 +++++++-------- .../nf-core/modules/samtools/index/main.nf | 17 ++- .../nf-core/modules/samtools/index/meta.yml | 92 ++++++++-------- modules/nf-core/modules/samtools/sort/main.nf | 10 +- .../nf-core/modules/samtools/sort/meta.yml | 74 ++++++------- .../nf-core/modules/samtools/stats/main.nf | 16 ++- .../nf-core/modules/samtools/stats/meta.yml | 90 +++++++-------- .../modules/subread/featurecounts/main.nf | 3 + .../modules/subread/featurecounts/meta.yml | 18 +-- modules/nf-core/modules/trimgalore/main.nf | 3 + modules/nf-core/modules/trimgalore/meta.yml | 104 +++++++++--------- .../modules/ucsc/bedgraphtobigwig/main.nf | 3 + modules/nf-core/modules/untar/main.nf | 5 +- modules/nf-core/modules/untar/meta.yml | 42 +++---- subworkflows/nf-core/align_bwa_mem.nf | 2 +- 61 files changed, 820 insertions(+), 705 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 537f057d9..bd17ccf3b 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -196,7 +196,7 @@ if (params.aligner == 'bwa') { '-M', params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' ].join(' ').trim() - ext.args2 = '-h -F 0x0100 -O BAM' + ext.args2 = '-bhS -F 0x0100 -O BAM' ext.prefix = { "${meta.id}.Lb" } publishDir = [ path: { "${params.outdir}/${params.aligner}/library" }, diff --git a/modules.json b/modules.json index 135a6859f..d0220c025 100644 --- a/modules.json +++ b/modules.json @@ -4,94 +4,94 @@ "repos": { "nf-core/modules": { "bowtie2/align": { - "git_sha": "3f9a0285816a2e0ae73a3875fb5ae4b409da5952" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "bowtie2/build": { - "git_sha": "e3285528aca2733ff2d544cb5e5fcc34599226f3" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "bwa/index": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "bwa/mem": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "950700bcdc0e9a2b6883d40d2c51c6fc435cd714" }, "custom/dumpsoftwareversions": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "custom/getchromsizes": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + "git_sha": "950700bcdc0e9a2b6883d40d2c51c6fc435cd714" }, "deeptools/computematrix": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "deeptools/plotfingerprint": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "deeptools/plotheatmap": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "deeptools/plotprofile": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "fastqc": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "gffread": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "gunzip": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "homer/annotatepeaks": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "macs2/callpeak": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "multiqc": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "phantompeakqualtools": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e20e57f90b6787ac9a010a980cf6ea98bd990046" }, "picard/collectmultiplemetrics": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "picard/markduplicates": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "picard/mergesamfiles": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "preseq/lcextrap": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "samtools/flagstat": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + "git_sha": "1ad73f1b2abdea9398680d6d20014838135c9a35" }, "samtools/idxstats": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + "git_sha": "1ad73f1b2abdea9398680d6d20014838135c9a35" }, "samtools/index": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + "git_sha": "1ad73f1b2abdea9398680d6d20014838135c9a35" }, "samtools/sort": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "1ad73f1b2abdea9398680d6d20014838135c9a35" }, "samtools/stats": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + "git_sha": "1ad73f1b2abdea9398680d6d20014838135c9a35" }, "subread/featurecounts": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "trimgalore": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "ucsc/bedgraphtobigwig": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e20e57f90b6787ac9a010a980cf6ea98bd990046" }, "untar": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + "git_sha": "7ec09d0ef4df89617baacc9b2dafcddb7cd4b05a" } } } diff --git a/modules/nf-core/modules/bowtie2/align/main.nf b/modules/nf-core/modules/bowtie2/align/main.nf index 20b08f721..7e8a9659b 100644 --- a/modules/nf-core/modules/bowtie2/align/main.nf +++ b/modules/nf-core/modules/bowtie2/align/main.nf @@ -18,6 +18,9 @@ process BOWTIE2_ALIGN { tuple val(meta), path('*fastq.gz'), emit: fastq, optional:true path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def args2 = task.ext.args2 ?: '' diff --git a/modules/nf-core/modules/bowtie2/align/meta.yml b/modules/nf-core/modules/bowtie2/align/meta.yml index 77c9e3970..f80421eca 100644 --- a/modules/nf-core/modules/bowtie2/align/meta.yml +++ b/modules/nf-core/modules/bowtie2/align/meta.yml @@ -1,51 +1,51 @@ name: bowtie2_align description: Align reads to a reference genome using bowtie2 keywords: - - align - - fasta - - genome - - reference + - align + - fasta + - genome + - reference tools: - - bowtie2: - description: | - Bowtie 2 is an ultrafast and memory-efficient tool for aligning - sequencing reads to long reference sequences. - homepage: http://bowtie-bio.sourceforge.net/bowtie2/index.shtml - documentation: http://bowtie-bio.sourceforge.net/bowtie2/manual.shtml - doi: 10.1038/nmeth.1923 - licence: ['GPL-3.0-or-later'] + - bowtie2: + description: | + Bowtie 2 is an ultrafast and memory-efficient tool for aligning + sequencing reads to long reference sequences. + homepage: http://bowtie-bio.sourceforge.net/bowtie2/index.shtml + documentation: http://bowtie-bio.sourceforge.net/bowtie2/manual.shtml + doi: 10.1038/nmeth.1923 + licence: ["GPL-3.0-or-later"] input: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - reads: - type: file - description: | - List of input FastQ files of size 1 and 2 for single-end and paired-end data, - respectively. - - index: - type: file - description: Bowtie2 genome index files - pattern: "*.ebwt" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - reads: + type: file + description: | + List of input FastQ files of size 1 and 2 for single-end and paired-end data, + respectively. + - index: + type: file + description: Bowtie2 genome index files + pattern: "*.ebwt" output: - - bam: - type: file - description: Output BAM file containing read alignments - pattern: "*.{bam}" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" - - fastq: - type: file - description: Unaligned FastQ files - pattern: "*.fastq.gz" - - log: - type: file - description: Aligment log - pattern: "*.log" + - bam: + type: file + description: Output BAM file containing read alignments + pattern: "*.{bam}" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" + - fastq: + type: file + description: Unaligned FastQ files + pattern: "*.fastq.gz" + - log: + type: file + description: Aligment log + pattern: "*.log" authors: - - "@joseespinosa" - - "@drpatelh" + - "@joseespinosa" + - "@drpatelh" diff --git a/modules/nf-core/modules/bowtie2/build/main.nf b/modules/nf-core/modules/bowtie2/build/main.nf index da2e9ed52..a4da62d07 100644 --- a/modules/nf-core/modules/bowtie2/build/main.nf +++ b/modules/nf-core/modules/bowtie2/build/main.nf @@ -14,6 +14,9 @@ process BOWTIE2_BUILD { path 'bowtie2' , emit: index path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' """ diff --git a/modules/nf-core/modules/bowtie2/build/meta.yml b/modules/nf-core/modules/bowtie2/build/meta.yml index ecc54e9b0..2da9a2171 100644 --- a/modules/nf-core/modules/bowtie2/build/meta.yml +++ b/modules/nf-core/modules/bowtie2/build/meta.yml @@ -1,33 +1,33 @@ name: bowtie2_build description: Builds bowtie index for reference genome keywords: - - build - - index - - fasta - - genome - - reference + - build + - index + - fasta + - genome + - reference tools: - - bowtie2: - description: | - Bowtie 2 is an ultrafast and memory-efficient tool for aligning - sequencing reads to long reference sequences. - homepage: http://bowtie-bio.sourceforge.net/bowtie2/index.shtml - documentation: http://bowtie-bio.sourceforge.net/bowtie2/manual.shtml - doi: 10.1038/nmeth.1923 - licence: ['GPL-3.0-or-later'] + - bowtie2: + description: | + Bowtie 2 is an ultrafast and memory-efficient tool for aligning + sequencing reads to long reference sequences. + homepage: http://bowtie-bio.sourceforge.net/bowtie2/index.shtml + documentation: http://bowtie-bio.sourceforge.net/bowtie2/manual.shtml + doi: 10.1038/nmeth.1923 + licence: ["GPL-3.0-or-later"] input: - - fasta: - type: file - description: Input genome fasta file + - fasta: + type: file + description: Input genome fasta file output: - - index: - type: file - description: Bowtie2 genome index files - pattern: "*.bt2" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - index: + type: file + description: Bowtie2 genome index files + pattern: "*.bt2" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@joseespinosa" - - "@drpatelh" + - "@joseespinosa" + - "@drpatelh" diff --git a/modules/nf-core/modules/bwa/index/main.nf b/modules/nf-core/modules/bwa/index/main.nf index 891027377..3affbf16b 100644 --- a/modules/nf-core/modules/bwa/index/main.nf +++ b/modules/nf-core/modules/bwa/index/main.nf @@ -14,6 +14,9 @@ process BWA_INDEX { path "bwa" , emit: index path "versions.yml", emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' """ diff --git a/modules/nf-core/modules/bwa/index/meta.yml b/modules/nf-core/modules/bwa/index/meta.yml index 11d62df37..2bbd81d9c 100644 --- a/modules/nf-core/modules/bwa/index/meta.yml +++ b/modules/nf-core/modules/bwa/index/meta.yml @@ -1,32 +1,32 @@ name: bwa_index description: Create BWA index for reference genome keywords: - - index - - fasta - - genome - - reference + - index + - fasta + - genome + - reference tools: - - bwa: - description: | - BWA is a software package for mapping DNA sequences against - a large reference genome, such as the human genome. - homepage: http://bio-bwa.sourceforge.net/ - documentation: http://www.htslib.org/doc/samtools.html - arxiv: arXiv:1303.3997 - licence: ['GPL-3.0-or-later'] + - bwa: + description: | + BWA is a software package for mapping DNA sequences against + a large reference genome, such as the human genome. + homepage: http://bio-bwa.sourceforge.net/ + documentation: http://www.htslib.org/doc/samtools.html + arxiv: arXiv:1303.3997 + licence: ["GPL-3.0-or-later"] input: - - fasta: - type: file - description: Input genome fasta file + - fasta: + type: file + description: Input genome fasta file output: - - index: - type: file - description: BWA genome index files - pattern: "*.{amb,ann,bwt,pac,sa}" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - index: + type: file + description: BWA genome index files + pattern: "*.{amb,ann,bwt,pac,sa}" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@drpatelh" - - "@maxulysse" + - "@drpatelh" + - "@maxulysse" diff --git a/modules/nf-core/modules/bwa/mem/main.nf b/modules/nf-core/modules/bwa/mem/main.nf index 801293a8f..27ea6f42e 100644 --- a/modules/nf-core/modules/bwa/mem/main.nf +++ b/modules/nf-core/modules/bwa/mem/main.nf @@ -2,24 +2,29 @@ process BWA_MEM { tag "$meta.id" label 'process_high' - conda (params.enable_conda ? "bioconda::bwa=0.7.17 bioconda::samtools=1.12" : null) + conda (params.enable_conda ? "bioconda::bwa=0.7.17 bioconda::samtools=1.15" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:66ed1b38d280722529bb8a0167b0cf02f8a0b488-0' : - 'quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:66ed1b38d280722529bb8a0167b0cf02f8a0b488-0' }" + 'https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:c56a3aabc8d64e52d5b9da1e8ecec2031668596d-0' : + 'quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:c56a3aabc8d64e52d5b9da1e8ecec2031668596d-0' }" input: tuple val(meta), path(reads) path index + val sort_bam output: tuple val(meta), path("*.bam"), emit: bam path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def args2 = task.ext.args2 ?: '' def prefix = task.ext.prefix ?: "${meta.id}" def read_group = meta.read_group ? "-R ${meta.read_group}" : "" + def samtools_command = sort_bam ? 'sort' : 'view' """ INDEX=`find -L ./ -name "*.amb" | sed 's/.amb//'` @@ -29,7 +34,7 @@ process BWA_MEM { -t $task.cpus \\ \$INDEX \\ $reads \\ - | samtools view $args2 -@ $task.cpus -bhS -o ${prefix}.bam - + | samtools $samtools_command $args2 --threads $task.cpus -o ${prefix}.bam - cat <<-END_VERSIONS > versions.yml "${task.process}": diff --git a/modules/nf-core/modules/bwa/mem/meta.yml b/modules/nf-core/modules/bwa/mem/meta.yml index 61eaddef6..f84c5227b 100644 --- a/modules/nf-core/modules/bwa/mem/meta.yml +++ b/modules/nf-core/modules/bwa/mem/meta.yml @@ -1,46 +1,50 @@ name: bwa_mem description: Performs fastq alignment to a fasta reference using BWA keywords: - - mem - - bwa - - alignment - - map - - fastq - - bam - - sam + - mem + - bwa + - alignment + - map + - fastq + - bam + - sam tools: - - bwa: - description: | - BWA is a software package for mapping DNA sequences against - a large reference genome, such as the human genome. - homepage: http://bio-bwa.sourceforge.net/ - documentation: http://www.htslib.org/doc/samtools.html - arxiv: arXiv:1303.3997 - licence: ['GPL-3.0-or-later'] + - bwa: + description: | + BWA is a software package for mapping DNA sequences against + a large reference genome, such as the human genome. + homepage: http://bio-bwa.sourceforge.net/ + documentation: http://www.htslib.org/doc/samtools.html + arxiv: arXiv:1303.3997 + licence: ["GPL-3.0-or-later"] input: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - reads: - type: file - description: | - List of input FastQ files of size 1 and 2 for single-end and paired-end data, - respectively. - - index: - type: file - description: BWA genome index files - pattern: "Directory containing BWA index *.{amb,ann,bwt,pac,sa}" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - reads: + type: file + description: | + List of input FastQ files of size 1 and 2 for single-end and paired-end data, + respectively. + - index: + type: file + description: BWA genome index files + pattern: "Directory containing BWA index *.{amb,ann,bwt,pac,sa}" + - sort_bam: + type: boolean + description: use samtools sort (true) or samtools view (false) + pattern: "true or false" output: - - bam: - type: file - description: Output BAM file containing read alignments - pattern: "*.{bam}" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - bam: + type: file + description: Output BAM file containing read alignments + pattern: "*.{bam}" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@drpatelh" - - "@jeremy1805" + - "@drpatelh" + - "@jeremy1805" diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf b/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf index 934bb4672..327d51005 100644 --- a/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf @@ -15,6 +15,9 @@ process CUSTOM_DUMPSOFTWAREVERSIONS { path "software_versions_mqc.yml", emit: mqc_yml path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' template 'dumpsoftwareversions.py' diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml b/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml index 5b5b8a602..60b546a01 100644 --- a/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml @@ -8,7 +8,7 @@ tools: description: Custom module used to dump software versions within the nf-core pipeline template homepage: https://github.com/nf-core/tools documentation: https://github.com/nf-core/tools - licence: ['MIT'] + licence: ["MIT"] input: - versions: type: file diff --git a/modules/nf-core/modules/custom/getchromsizes/main.nf b/modules/nf-core/modules/custom/getchromsizes/main.nf index 270b3f489..bbcfa9bec 100644 --- a/modules/nf-core/modules/custom/getchromsizes/main.nf +++ b/modules/nf-core/modules/custom/getchromsizes/main.nf @@ -2,10 +2,10 @@ process CUSTOM_GETCHROMSIZES { tag "$fasta" label 'process_low' - conda (params.enable_conda ? "bioconda::samtools=1.14" : null) + conda (params.enable_conda ? "bioconda::samtools=1.15" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/samtools:1.14--hb421002_0' : - 'quay.io/biocontainers/samtools:1.14--hb421002_0' }" + 'https://depot.galaxyproject.org/singularity/samtools:1.15--h1170115_1' : + 'quay.io/biocontainers/samtools:1.15--h1170115_1' }" input: path fasta @@ -15,6 +15,9 @@ process CUSTOM_GETCHROMSIZES { path '*.fai' , emit: fai path "versions.yml", emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' """ diff --git a/modules/nf-core/modules/custom/getchromsizes/meta.yml b/modules/nf-core/modules/custom/getchromsizes/meta.yml index eb1db4bb0..ee6c25718 100644 --- a/modules/nf-core/modules/custom/getchromsizes/meta.yml +++ b/modules/nf-core/modules/custom/getchromsizes/meta.yml @@ -11,7 +11,7 @@ tools: documentation: http://www.htslib.org/doc/samtools.html tool_dev_url: https://github.com/samtools/samtools doi: 10.1093/bioinformatics/btp352 - licence: ['MIT'] + licence: ["MIT"] input: - fasta: @@ -33,7 +33,6 @@ output: description: File containing software version pattern: "versions.yml" - authors: - "@tamara-hodgetts" - "@chris-cheshire" diff --git a/modules/nf-core/modules/deeptools/computematrix/main.nf b/modules/nf-core/modules/deeptools/computematrix/main.nf index 70be934bf..96dfef3c6 100644 --- a/modules/nf-core/modules/deeptools/computematrix/main.nf +++ b/modules/nf-core/modules/deeptools/computematrix/main.nf @@ -16,6 +16,9 @@ process DEEPTOOLS_COMPUTEMATRIX { tuple val(meta), path("*.mat.tab"), emit: table path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" diff --git a/modules/nf-core/modules/deeptools/computematrix/meta.yml b/modules/nf-core/modules/deeptools/computematrix/meta.yml index 584fade14..eaa990dd9 100644 --- a/modules/nf-core/modules/deeptools/computematrix/meta.yml +++ b/modules/nf-core/modules/deeptools/computematrix/meta.yml @@ -12,7 +12,7 @@ tools: documentation: https://deeptools.readthedocs.io/en/develop/index.html tool_dev_url: https://github.com/deeptools/deepTools doi: "10.1093/nar/gku365" - licence: ['GPL v3'] + licence: ["GPL v3"] input: - meta: diff --git a/modules/nf-core/modules/deeptools/plotfingerprint/main.nf b/modules/nf-core/modules/deeptools/plotfingerprint/main.nf index 7925c9a97..83613be7b 100644 --- a/modules/nf-core/modules/deeptools/plotfingerprint/main.nf +++ b/modules/nf-core/modules/deeptools/plotfingerprint/main.nf @@ -16,6 +16,9 @@ process DEEPTOOLS_PLOTFINGERPRINT { tuple val(meta), path("*.qcmetrics.txt"), emit: metrics path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" diff --git a/modules/nf-core/modules/deeptools/plotfingerprint/meta.yml b/modules/nf-core/modules/deeptools/plotfingerprint/meta.yml index 3acd14712..07c257480 100644 --- a/modules/nf-core/modules/deeptools/plotfingerprint/meta.yml +++ b/modules/nf-core/modules/deeptools/plotfingerprint/meta.yml @@ -12,7 +12,7 @@ tools: documentation: https://deeptools.readthedocs.io/en/develop/index.html tool_dev_url: https://github.com/deeptools/deepTools doi: "10.1093/nar/gku365" - licence: ['GPL v3'] + licence: ["GPL v3"] input: - meta: diff --git a/modules/nf-core/modules/deeptools/plotheatmap/main.nf b/modules/nf-core/modules/deeptools/plotheatmap/main.nf index 992c90583..1e402e391 100644 --- a/modules/nf-core/modules/deeptools/plotheatmap/main.nf +++ b/modules/nf-core/modules/deeptools/plotheatmap/main.nf @@ -15,6 +15,9 @@ process DEEPTOOLS_PLOTHEATMAP { tuple val(meta), path("*.tab"), emit: table path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" diff --git a/modules/nf-core/modules/deeptools/plotheatmap/meta.yml b/modules/nf-core/modules/deeptools/plotheatmap/meta.yml index 34f2865b8..ea206fb67 100644 --- a/modules/nf-core/modules/deeptools/plotheatmap/meta.yml +++ b/modules/nf-core/modules/deeptools/plotheatmap/meta.yml @@ -12,7 +12,7 @@ tools: documentation: https://deeptools.readthedocs.io/en/develop/index.html tool_dev_url: https://github.com/deeptools/deepTools doi: "10.1093/nar/gku365" - licence: ['GPL v3'] + licence: ["GPL v3"] input: - meta: diff --git a/modules/nf-core/modules/deeptools/plotprofile/main.nf b/modules/nf-core/modules/deeptools/plotprofile/main.nf index 60184fa6b..d83a94938 100644 --- a/modules/nf-core/modules/deeptools/plotprofile/main.nf +++ b/modules/nf-core/modules/deeptools/plotprofile/main.nf @@ -15,6 +15,9 @@ process DEEPTOOLS_PLOTPROFILE { tuple val(meta), path("*.tab"), emit: table path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" diff --git a/modules/nf-core/modules/deeptools/plotprofile/meta.yml b/modules/nf-core/modules/deeptools/plotprofile/meta.yml index 5b61aed4d..795fda444 100644 --- a/modules/nf-core/modules/deeptools/plotprofile/meta.yml +++ b/modules/nf-core/modules/deeptools/plotprofile/meta.yml @@ -12,7 +12,7 @@ tools: documentation: https://deeptools.readthedocs.io/en/develop/index.html tool_dev_url: https://github.com/deeptools/deepTools doi: "10.1093/nar/gku365" - licence: ['GPL v3'] + licence: ["GPL v3"] input: - meta: diff --git a/modules/nf-core/modules/fastqc/main.nf b/modules/nf-core/modules/fastqc/main.nf index d250eca07..ed6b8c50b 100644 --- a/modules/nf-core/modules/fastqc/main.nf +++ b/modules/nf-core/modules/fastqc/main.nf @@ -15,6 +15,9 @@ process FASTQC { tuple val(meta), path("*.zip") , emit: zip path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' // Add soft-links to original FastQs for consistent naming in pipeline diff --git a/modules/nf-core/modules/fastqc/meta.yml b/modules/nf-core/modules/fastqc/meta.yml index b09553a3c..4da5bb5a0 100644 --- a/modules/nf-core/modules/fastqc/meta.yml +++ b/modules/nf-core/modules/fastqc/meta.yml @@ -1,52 +1,52 @@ name: fastqc description: Run FastQC on sequenced reads keywords: - - quality control - - qc - - adapters - - fastq + - quality control + - qc + - adapters + - fastq tools: - - fastqc: - description: | - FastQC gives general quality metrics about your reads. - It provides information about the quality score distribution - across your reads, the per base sequence content (%A/C/G/T). - You get information about adapter contamination and other - overrepresented sequences. - homepage: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/ - documentation: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/ - licence: ['GPL-2.0-only'] + - fastqc: + description: | + FastQC gives general quality metrics about your reads. + It provides information about the quality score distribution + across your reads, the per base sequence content (%A/C/G/T). + You get information about adapter contamination and other + overrepresented sequences. + homepage: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/ + documentation: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/ + licence: ["GPL-2.0-only"] input: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - reads: - type: file - description: | - List of input FastQ files of size 1 and 2 for single-end and paired-end data, - respectively. + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - reads: + type: file + description: | + List of input FastQ files of size 1 and 2 for single-end and paired-end data, + respectively. output: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - html: - type: file - description: FastQC report - pattern: "*_{fastqc.html}" - - zip: - type: file - description: FastQC report archive - pattern: "*_{fastqc.zip}" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - html: + type: file + description: FastQC report + pattern: "*_{fastqc.html}" + - zip: + type: file + description: FastQC report archive + pattern: "*_{fastqc.zip}" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@drpatelh" - - "@grst" - - "@ewels" - - "@FelixKrueger" + - "@drpatelh" + - "@grst" + - "@ewels" + - "@FelixKrueger" diff --git a/modules/nf-core/modules/gffread/main.nf b/modules/nf-core/modules/gffread/main.nf index d31f76f82..7c575c97f 100644 --- a/modules/nf-core/modules/gffread/main.nf +++ b/modules/nf-core/modules/gffread/main.nf @@ -14,9 +14,12 @@ process GFFREAD { path "*.gtf" , emit: gtf path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: - def args = task.ext.args ?: '' - def prefix = task.ext.suffix ? "${gff.baseName}${task.ext.suffix}" : "${gff.baseName}" + def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${gff.baseName}" """ gffread \\ $gff \\ diff --git a/modules/nf-core/modules/gffread/meta.yml b/modules/nf-core/modules/gffread/meta.yml index bf1a15cba..203357477 100644 --- a/modules/nf-core/modules/gffread/meta.yml +++ b/modules/nf-core/modules/gffread/meta.yml @@ -11,13 +11,13 @@ tools: documentation: http://ccb.jhu.edu/software/stringtie/gff.shtml#gffread tool_dev_url: https://github.com/gpertea/gffread doi: 10.12688/f1000research.23297.1 - licence: ['MIT'] + licence: ["MIT"] input: - gff: - type: file - description: A reference file in either the GFF3, GFF2 or GTF format. - pattern: "*.{gff, gtf}" + type: file + description: A reference file in either the GFF3, GFF2 or GTF format. + pattern: "*.{gff, gtf}" output: - gtf: diff --git a/modules/nf-core/modules/gunzip/main.nf b/modules/nf-core/modules/gunzip/main.nf index 77a4e546b..9d4b06669 100644 --- a/modules/nf-core/modules/gunzip/main.nf +++ b/modules/nf-core/modules/gunzip/main.nf @@ -14,6 +14,9 @@ process GUNZIP { tuple val(meta), path("$gunzip"), emit: gunzip path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' gunzip = archive.toString() - '.gz' diff --git a/modules/nf-core/modules/gunzip/meta.yml b/modules/nf-core/modules/gunzip/meta.yml index ea1f15460..4d2ebc84e 100644 --- a/modules/nf-core/modules/gunzip/meta.yml +++ b/modules/nf-core/modules/gunzip/meta.yml @@ -1,34 +1,34 @@ name: gunzip description: Compresses and decompresses files. keywords: - - gunzip - - compression + - gunzip + - compression tools: - - gunzip: - description: | - gzip is a file format and a software application used for file compression and decompression. - documentation: https://www.gnu.org/software/gzip/manual/gzip.html - licence: ['GPL-3.0-or-later'] + - gunzip: + description: | + gzip is a file format and a software application used for file compression and decompression. + documentation: https://www.gnu.org/software/gzip/manual/gzip.html + licence: ["GPL-3.0-or-later"] input: - - meta: - type: map - description: | - Optional groovy Map containing meta information - e.g. [ id:'test', single_end:false ] - - archive: - type: file - description: File to be compressed/uncompressed - pattern: "*.*" + - meta: + type: map + description: | + Optional groovy Map containing meta information + e.g. [ id:'test', single_end:false ] + - archive: + type: file + description: File to be compressed/uncompressed + pattern: "*.*" output: - - gunzip: - type: file - description: Compressed/uncompressed file - pattern: "*.*" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - gunzip: + type: file + description: Compressed/uncompressed file + pattern: "*.*" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@joseespinosa" - - "@drpatelh" - - "@jfy133" + - "@joseespinosa" + - "@drpatelh" + - "@jfy133" diff --git a/modules/nf-core/modules/homer/annotatepeaks/main.nf b/modules/nf-core/modules/homer/annotatepeaks/main.nf index 84e0241a4..c9da82ed4 100644 --- a/modules/nf-core/modules/homer/annotatepeaks/main.nf +++ b/modules/nf-core/modules/homer/annotatepeaks/main.nf @@ -18,6 +18,9 @@ process HOMER_ANNOTATEPEAKS { tuple val(meta), path("*annotatePeaks.txt"), emit: txt path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" diff --git a/modules/nf-core/modules/homer/annotatepeaks/meta.yml b/modules/nf-core/modules/homer/annotatepeaks/meta.yml index c3ab9460e..b815e975d 100644 --- a/modules/nf-core/modules/homer/annotatepeaks/meta.yml +++ b/modules/nf-core/modules/homer/annotatepeaks/meta.yml @@ -10,7 +10,7 @@ tools: HOMER (Hypergeometric Optimization of Motif EnRichment) is a suite of tools for Motif Discovery and next-gen sequencing analysis. documentation: http://homer.ucsd.edu/homer/ doi: 10.1016/j.molcel.2010.05.004. - licence: ['GPL-3.0-or-later'] + licence: ["GPL-3.0-or-later"] input: - meta: type: map diff --git a/modules/nf-core/modules/macs2/callpeak/main.nf b/modules/nf-core/modules/macs2/callpeak/main.nf index c5c88f8e0..9aaf97a93 100644 --- a/modules/nf-core/modules/macs2/callpeak/main.nf +++ b/modules/nf-core/modules/macs2/callpeak/main.nf @@ -20,6 +20,9 @@ process MACS2_CALLPEAK { tuple val(meta), path("*.bed") , optional:true, emit: bed tuple val(meta), path("*.bdg") , optional:true, emit: bdg + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" diff --git a/modules/nf-core/modules/macs2/callpeak/meta.yml b/modules/nf-core/modules/macs2/callpeak/meta.yml index afb949ece..974ea33a6 100644 --- a/modules/nf-core/modules/macs2/callpeak/meta.yml +++ b/modules/nf-core/modules/macs2/callpeak/meta.yml @@ -1,10 +1,10 @@ name: macs2_callpeak description: Peak calling of enriched genomic regions of ChIP-seq and ATAC-seq experiments keywords: - - alignment - - atac-seq - - chip-seq - - peak-calling + - alignment + - atac-seq + - chip-seq + - peak-calling tools: - macs2: description: Model Based Analysis for ChIP-Seq data @@ -12,7 +12,7 @@ tools: documentation: https://docs.csc.fi/apps/macs2/ tool_dev_url: https://github.com/macs3-project/MACS doi: "https://doi.org/10.1101/496521" - licence: ['BSD'] + licence: ["BSD"] input: - meta: @@ -28,7 +28,8 @@ input: description: The control file - macs2_gsize: type: string - description: Effective genome size. It can be 1.0e+9 or 1000000000, or shortcuts:'hs' for human (2.7e9), + description: + Effective genome size. It can be 1.0e+9 or 1000000000, or shortcuts:'hs' for human (2.7e9), 'mm' for mouse (1.87e9), 'ce' for C. elegans (9e7) and 'dm' for fruitfly (1.2e8) output: diff --git a/modules/nf-core/modules/multiqc/main.nf b/modules/nf-core/modules/multiqc/main.nf index 3dceb162a..1264aac1e 100644 --- a/modules/nf-core/modules/multiqc/main.nf +++ b/modules/nf-core/modules/multiqc/main.nf @@ -1,10 +1,10 @@ process MULTIQC { label 'process_medium' - conda (params.enable_conda ? 'bioconda::multiqc=1.11' : null) + conda (params.enable_conda ? 'bioconda::multiqc=1.12' : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/multiqc:1.11--pyhdfd78af_0' : - 'quay.io/biocontainers/multiqc:1.11--pyhdfd78af_0' }" + 'https://depot.galaxyproject.org/singularity/multiqc:1.12--pyhdfd78af_0' : + 'quay.io/biocontainers/multiqc:1.12--pyhdfd78af_0' }" input: path multiqc_files @@ -15,6 +15,9 @@ process MULTIQC { path "*_plots" , optional:true, emit: plots path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' """ diff --git a/modules/nf-core/modules/multiqc/meta.yml b/modules/nf-core/modules/multiqc/meta.yml index 63c75a450..6fa891efc 100644 --- a/modules/nf-core/modules/multiqc/meta.yml +++ b/modules/nf-core/modules/multiqc/meta.yml @@ -1,40 +1,40 @@ name: MultiQC description: Aggregate results from bioinformatics analyses across many samples into a single report keywords: - - QC - - bioinformatics tools - - Beautiful stand-alone HTML report + - QC + - bioinformatics tools + - Beautiful stand-alone HTML report tools: - - multiqc: - description: | - MultiQC searches a given directory for analysis logs and compiles a HTML report. - It's a general use tool, perfect for summarising the output from numerous bioinformatics tools. - homepage: https://multiqc.info/ - documentation: https://multiqc.info/docs/ - licence: ['GPL-3.0-or-later'] + - multiqc: + description: | + MultiQC searches a given directory for analysis logs and compiles a HTML report. + It's a general use tool, perfect for summarising the output from numerous bioinformatics tools. + homepage: https://multiqc.info/ + documentation: https://multiqc.info/docs/ + licence: ["GPL-3.0-or-later"] input: - - multiqc_files: - type: file - description: | - List of reports / files recognised by MultiQC, for example the html and zip output of FastQC + - multiqc_files: + type: file + description: | + List of reports / files recognised by MultiQC, for example the html and zip output of FastQC output: - - report: - type: file - description: MultiQC report file - pattern: "multiqc_report.html" - - data: - type: dir - description: MultiQC data dir - pattern: "multiqc_data" - - plots: - type: file - description: Plots created by MultiQC - pattern: "*_data" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - report: + type: file + description: MultiQC report file + pattern: "multiqc_report.html" + - data: + type: dir + description: MultiQC data dir + pattern: "multiqc_data" + - plots: + type: file + description: Plots created by MultiQC + pattern: "*_data" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@abhi18av" - - "@bunop" - - "@drpatelh" + - "@abhi18av" + - "@bunop" + - "@drpatelh" diff --git a/modules/nf-core/modules/phantompeakqualtools/main.nf b/modules/nf-core/modules/phantompeakqualtools/main.nf index 6fe34cc28..c8325b059 100644 --- a/modules/nf-core/modules/phantompeakqualtools/main.nf +++ b/modules/nf-core/modules/phantompeakqualtools/main.nf @@ -18,6 +18,9 @@ process PHANTOMPEAKQUALTOOLS { tuple val(meta), path("*.Rdata"), emit: rdata path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" diff --git a/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf b/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf index 6b292534c..e023ea3c2 100644 --- a/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf +++ b/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf @@ -2,10 +2,10 @@ process PICARD_COLLECTMULTIPLEMETRICS { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? 'bioconda::picard=2.25.7' : null) + conda (params.enable_conda ? "bioconda::picard=2.26.10" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/picard:2.25.7--hdfd78af_0' : - 'quay.io/biocontainers/picard:2.25.7--hdfd78af_0' }" + 'https://depot.galaxyproject.org/singularity/picard:2.26.10--hdfd78af_0' : + 'quay.io/biocontainers/picard:2.26.10--hdfd78af_0' }" input: tuple val(meta), path(bam) @@ -16,6 +16,9 @@ process PICARD_COLLECTMULTIPLEMETRICS { tuple val(meta), path("*.pdf") , emit: pdf path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" diff --git a/modules/nf-core/modules/picard/collectmultiplemetrics/meta.yml b/modules/nf-core/modules/picard/collectmultiplemetrics/meta.yml index 613afc622..68b5c65ee 100644 --- a/modules/nf-core/modules/picard/collectmultiplemetrics/meta.yml +++ b/modules/nf-core/modules/picard/collectmultiplemetrics/meta.yml @@ -1,50 +1,50 @@ name: picard_collectmultiplemetrics description: Collect multiple metrics from a BAM file keywords: - - alignment - - metrics - - statistics - - insert - - quality - - bam + - alignment + - metrics + - statistics + - insert + - quality + - bam tools: - - picard: - description: | - A set of command line tools (in Java) for manipulating high-throughput sequencing (HTS) - data and formats such as SAM/BAM/CRAM and VCF. - homepage: https://broadinstitute.github.io/picard/ - documentation: https://broadinstitute.github.io/picard/ - licence: ['MIT'] + - picard: + description: | + A set of command line tools (in Java) for manipulating high-throughput sequencing (HTS) + data and formats such as SAM/BAM/CRAM and VCF. + homepage: https://broadinstitute.github.io/picard/ + documentation: https://broadinstitute.github.io/picard/ + licence: ["MIT"] input: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - bam: - type: file - description: BAM file - pattern: "*.{bam}" - - fasta: - type: file - description: Genome fasta file + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - bam: + type: file + description: BAM file + pattern: "*.{bam}" + - fasta: + type: file + description: Genome fasta file output: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - metrics: - type: file - description: Alignment metrics files generated by picard - pattern: "*_{metrics}" - - pdf: - type: file - description: PDF plots of metrics - pattern: "*.{pdf}" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - metrics: + type: file + description: Alignment metrics files generated by picard + pattern: "*_{metrics}" + - pdf: + type: file + description: PDF plots of metrics + pattern: "*.{pdf}" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@drpatelh" + - "@drpatelh" diff --git a/modules/nf-core/modules/picard/markduplicates/main.nf b/modules/nf-core/modules/picard/markduplicates/main.nf index d3bf69385..5196b6edf 100644 --- a/modules/nf-core/modules/picard/markduplicates/main.nf +++ b/modules/nf-core/modules/picard/markduplicates/main.nf @@ -2,10 +2,10 @@ process PICARD_MARKDUPLICATES { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? 'bioconda::picard=2.25.7' : null) + conda (params.enable_conda ? "bioconda::picard=2.26.10" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/picard:2.25.7--hdfd78af_0' : - 'quay.io/biocontainers/picard:2.25.7--hdfd78af_0' }" + 'https://depot.galaxyproject.org/singularity/picard:2.26.10--hdfd78af_0' : + 'quay.io/biocontainers/picard:2.26.10--hdfd78af_0' }" input: tuple val(meta), path(bam) @@ -16,6 +16,9 @@ process PICARD_MARKDUPLICATES { tuple val(meta), path("*.metrics.txt"), emit: metrics path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" diff --git a/modules/nf-core/modules/picard/markduplicates/meta.yml b/modules/nf-core/modules/picard/markduplicates/meta.yml index c9a08b36f..842817bcd 100644 --- a/modules/nf-core/modules/picard/markduplicates/meta.yml +++ b/modules/nf-core/modules/picard/markduplicates/meta.yml @@ -14,7 +14,7 @@ tools: data and formats such as SAM/BAM/CRAM and VCF. homepage: https://broadinstitute.github.io/picard/ documentation: https://broadinstitute.github.io/picard/ - licence: ['MIT'] + licence: ["MIT"] input: - meta: type: map diff --git a/modules/nf-core/modules/picard/mergesamfiles/main.nf b/modules/nf-core/modules/picard/mergesamfiles/main.nf index 867965932..ef5c39807 100644 --- a/modules/nf-core/modules/picard/mergesamfiles/main.nf +++ b/modules/nf-core/modules/picard/mergesamfiles/main.nf @@ -2,10 +2,10 @@ process PICARD_MERGESAMFILES { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? 'bioconda::picard=2.25.7' : null) + conda (params.enable_conda ? "bioconda::picard=2.26.10" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/picard:2.25.7--hdfd78af_0' : - 'quay.io/biocontainers/picard:2.25.7--hdfd78af_0' }" + 'https://depot.galaxyproject.org/singularity/picard:2.26.10--hdfd78af_0' : + 'quay.io/biocontainers/picard:2.26.10--hdfd78af_0' }" input: tuple val(meta), path(bams) @@ -14,6 +14,9 @@ process PICARD_MERGESAMFILES { tuple val(meta), path("*.bam"), emit: bam path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" diff --git a/modules/nf-core/modules/picard/mergesamfiles/meta.yml b/modules/nf-core/modules/picard/mergesamfiles/meta.yml index 3d010c3ce..5f07ecd0a 100644 --- a/modules/nf-core/modules/picard/mergesamfiles/meta.yml +++ b/modules/nf-core/modules/picard/mergesamfiles/meta.yml @@ -1,41 +1,41 @@ name: picard_mergesamfiles description: Merges multiple BAM files into a single file keywords: - - merge - - alignment - - bam - - sam + - merge + - alignment + - bam + - sam tools: - - picard: - description: | - A set of command line tools (in Java) for manipulating high-throughput sequencing (HTS) - data and formats such as SAM/BAM/CRAM and VCF. - homepage: https://broadinstitute.github.io/picard/ - documentation: https://broadinstitute.github.io/picard/ - licence: ['MIT'] + - picard: + description: | + A set of command line tools (in Java) for manipulating high-throughput sequencing (HTS) + data and formats such as SAM/BAM/CRAM and VCF. + homepage: https://broadinstitute.github.io/picard/ + documentation: https://broadinstitute.github.io/picard/ + licence: ["MIT"] input: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - bam: - type: file - description: List of BAM files - pattern: "*.{bam}" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - bam: + type: file + description: List of BAM files + pattern: "*.{bam}" output: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - bam: - type: file - description: Merged BAM file - pattern: "*.{bam}" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - bam: + type: file + description: Merged BAM file + pattern: "*.{bam}" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@drpatelh" + - "@drpatelh" diff --git a/modules/nf-core/modules/preseq/lcextrap/main.nf b/modules/nf-core/modules/preseq/lcextrap/main.nf index b5bd06206..d6dd19e23 100644 --- a/modules/nf-core/modules/preseq/lcextrap/main.nf +++ b/modules/nf-core/modules/preseq/lcextrap/main.nf @@ -16,6 +16,9 @@ process PRESEQ_LCEXTRAP { tuple val(meta), path("*.log") , emit: log path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" diff --git a/modules/nf-core/modules/preseq/lcextrap/meta.yml b/modules/nf-core/modules/preseq/lcextrap/meta.yml index bdc61228f..0e33df250 100644 --- a/modules/nf-core/modules/preseq/lcextrap/meta.yml +++ b/modules/nf-core/modules/preseq/lcextrap/meta.yml @@ -11,7 +11,7 @@ tools: documentation: None tool_dev_url: None doi: "" - licence: ['GPL'] + licence: ["GPL"] input: - meta: diff --git a/modules/nf-core/modules/samtools/flagstat/main.nf b/modules/nf-core/modules/samtools/flagstat/main.nf index 03721d0b2..9e3440acd 100644 --- a/modules/nf-core/modules/samtools/flagstat/main.nf +++ b/modules/nf-core/modules/samtools/flagstat/main.nf @@ -2,10 +2,10 @@ process SAMTOOLS_FLAGSTAT { tag "$meta.id" label 'process_low' - conda (params.enable_conda ? "bioconda::samtools=1.14" : null) + conda (params.enable_conda ? "bioconda::samtools=1.15" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/samtools:1.14--hb421002_0' : - 'quay.io/biocontainers/samtools:1.14--hb421002_0' }" + 'https://depot.galaxyproject.org/singularity/samtools:1.15--h1170115_1' : + 'quay.io/biocontainers/samtools:1.15--h1170115_1' }" input: tuple val(meta), path(bam), path(bai) @@ -14,10 +14,18 @@ process SAMTOOLS_FLAGSTAT { tuple val(meta), path("*.flagstat"), emit: flagstat path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' """ - samtools flagstat --threads ${task.cpus-1} $bam > ${bam}.flagstat + samtools \\ + flagstat \\ + --threads ${task.cpus-1} \\ + $bam \\ + > ${bam}.flagstat + cat <<-END_VERSIONS > versions.yml "${task.process}": samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') diff --git a/modules/nf-core/modules/samtools/flagstat/meta.yml b/modules/nf-core/modules/samtools/flagstat/meta.yml index 9bd9ff891..952690639 100644 --- a/modules/nf-core/modules/samtools/flagstat/meta.yml +++ b/modules/nf-core/modules/samtools/flagstat/meta.yml @@ -1,49 +1,49 @@ name: samtools_flagstat description: Counts the number of alignments in a BAM/CRAM/SAM file for each FLAG type keywords: - - stats - - mapping - - counts - - bam - - sam - - cram + - stats + - mapping + - counts + - bam + - sam + - cram tools: - - samtools: - description: | - SAMtools is a set of utilities for interacting with and post-processing - short DNA sequence read alignments in the SAM, BAM and CRAM formats, written by Heng Li. - These files are generated as output by short read aligners like BWA. - homepage: http://www.htslib.org/ - documentation: hhttp://www.htslib.org/doc/samtools.html - doi: 10.1093/bioinformatics/btp352 - licence: ['MIT'] + - samtools: + description: | + SAMtools is a set of utilities for interacting with and post-processing + short DNA sequence read alignments in the SAM, BAM and CRAM formats, written by Heng Li. + These files are generated as output by short read aligners like BWA. + homepage: http://www.htslib.org/ + documentation: hhttp://www.htslib.org/doc/samtools.html + doi: 10.1093/bioinformatics/btp352 + licence: ["MIT"] input: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - bam: - type: file - description: BAM/CRAM/SAM file - pattern: "*.{bam,cram,sam}" - - bai: - type: file - description: Index for BAM/CRAM/SAM file - pattern: "*.{bai,crai,sai}" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - bam: + type: file + description: BAM/CRAM/SAM file + pattern: "*.{bam,cram,sam}" + - bai: + type: file + description: Index for BAM/CRAM/SAM file + pattern: "*.{bai,crai,sai}" output: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - flagstat: - type: file - description: File containing samtools flagstat output - pattern: "*.{flagstat}" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - flagstat: + type: file + description: File containing samtools flagstat output + pattern: "*.{flagstat}" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@drpatelh" + - "@drpatelh" diff --git a/modules/nf-core/modules/samtools/idxstats/main.nf b/modules/nf-core/modules/samtools/idxstats/main.nf index cd0686791..7d5cee172 100644 --- a/modules/nf-core/modules/samtools/idxstats/main.nf +++ b/modules/nf-core/modules/samtools/idxstats/main.nf @@ -2,10 +2,10 @@ process SAMTOOLS_IDXSTATS { tag "$meta.id" label 'process_low' - conda (params.enable_conda ? "bioconda::samtools=1.14" : null) + conda (params.enable_conda ? "bioconda::samtools=1.15" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/samtools:1.14--hb421002_0' : - 'quay.io/biocontainers/samtools:1.14--hb421002_0' }" + 'https://depot.galaxyproject.org/singularity/samtools:1.15--h1170115_1' : + 'quay.io/biocontainers/samtools:1.15--h1170115_1' }" input: tuple val(meta), path(bam), path(bai) @@ -14,10 +14,17 @@ process SAMTOOLS_IDXSTATS { tuple val(meta), path("*.idxstats"), emit: idxstats path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' """ - samtools idxstats $bam > ${bam}.idxstats + samtools \\ + idxstats \\ + $bam \\ + > ${bam}.idxstats + cat <<-END_VERSIONS > versions.yml "${task.process}": samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') diff --git a/modules/nf-core/modules/samtools/idxstats/meta.yml b/modules/nf-core/modules/samtools/idxstats/meta.yml index ec542f34b..3710ab882 100644 --- a/modules/nf-core/modules/samtools/idxstats/meta.yml +++ b/modules/nf-core/modules/samtools/idxstats/meta.yml @@ -1,50 +1,50 @@ name: samtools_idxstats description: Reports alignment summary statistics for a BAM/CRAM/SAM file keywords: - - stats - - mapping - - counts - - chromosome - - bam - - sam - - cram + - stats + - mapping + - counts + - chromosome + - bam + - sam + - cram tools: - - samtools: - description: | - SAMtools is a set of utilities for interacting with and post-processing - short DNA sequence read alignments in the SAM, BAM and CRAM formats, written by Heng Li. - These files are generated as output by short read aligners like BWA. - homepage: http://www.htslib.org/ - documentation: hhttp://www.htslib.org/doc/samtools.html - doi: 10.1093/bioinformatics/btp352 - licence: ['MIT'] + - samtools: + description: | + SAMtools is a set of utilities for interacting with and post-processing + short DNA sequence read alignments in the SAM, BAM and CRAM formats, written by Heng Li. + These files are generated as output by short read aligners like BWA. + homepage: http://www.htslib.org/ + documentation: hhttp://www.htslib.org/doc/samtools.html + doi: 10.1093/bioinformatics/btp352 + licence: ["MIT"] input: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - bam: - type: file - description: BAM/CRAM/SAM file - pattern: "*.{bam,cram,sam}" - - bai: - type: file - description: Index for BAM/CRAM/SAM file - pattern: "*.{bai,crai,sai}" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - bam: + type: file + description: BAM/CRAM/SAM file + pattern: "*.{bam,cram,sam}" + - bai: + type: file + description: Index for BAM/CRAM/SAM file + pattern: "*.{bai,crai,sai}" output: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - idxstats: - type: file - description: File containing samtools idxstats output - pattern: "*.{idxstats}" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - idxstats: + type: file + description: File containing samtools idxstats output + pattern: "*.{idxstats}" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@drpatelh" + - "@drpatelh" diff --git a/modules/nf-core/modules/samtools/index/main.nf b/modules/nf-core/modules/samtools/index/main.nf index b033e2258..e41cdcc88 100644 --- a/modules/nf-core/modules/samtools/index/main.nf +++ b/modules/nf-core/modules/samtools/index/main.nf @@ -2,24 +2,31 @@ process SAMTOOLS_INDEX { tag "$meta.id" label 'process_low' - conda (params.enable_conda ? "bioconda::samtools=1.14" : null) + conda (params.enable_conda ? "bioconda::samtools=1.15" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/samtools:1.14--hb421002_0' : - 'quay.io/biocontainers/samtools:1.14--hb421002_0' }" + 'https://depot.galaxyproject.org/singularity/samtools:1.15--h1170115_1' : + 'quay.io/biocontainers/samtools:1.15--h1170115_1' }" input: tuple val(meta), path(input) output: tuple val(meta), path("*.bai") , optional:true, emit: bai - tuple val(meta), path("*.crai"), optional:true, emit: crai tuple val(meta), path("*.csi") , optional:true, emit: csi + tuple val(meta), path("*.crai"), optional:true, emit: crai path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' """ - samtools index -@ ${task.cpus-1} $args $input + samtools \\ + index \\ + -@ ${task.cpus-1} \\ + $args \\ + $input cat <<-END_VERSIONS > versions.yml "${task.process}": diff --git a/modules/nf-core/modules/samtools/index/meta.yml b/modules/nf-core/modules/samtools/index/meta.yml index 0905b3cd6..e5cadbc24 100644 --- a/modules/nf-core/modules/samtools/index/meta.yml +++ b/modules/nf-core/modules/samtools/index/meta.yml @@ -1,53 +1,53 @@ name: samtools_index description: Index SAM/BAM/CRAM file keywords: - - index - - bam - - sam - - cram + - index + - bam + - sam + - cram tools: - - samtools: - description: | - SAMtools is a set of utilities for interacting with and post-processing - short DNA sequence read alignments in the SAM, BAM and CRAM formats, written by Heng Li. - These files are generated as output by short read aligners like BWA. - homepage: http://www.htslib.org/ - documentation: hhttp://www.htslib.org/doc/samtools.html - doi: 10.1093/bioinformatics/btp352 - licence: ['MIT'] + - samtools: + description: | + SAMtools is a set of utilities for interacting with and post-processing + short DNA sequence read alignments in the SAM, BAM and CRAM formats, written by Heng Li. + These files are generated as output by short read aligners like BWA. + homepage: http://www.htslib.org/ + documentation: hhttp://www.htslib.org/doc/samtools.html + doi: 10.1093/bioinformatics/btp352 + licence: ["MIT"] input: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - bam: - type: file - description: BAM/CRAM/SAM file - pattern: "*.{bam,cram,sam}" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - bam: + type: file + description: BAM/CRAM/SAM file + pattern: "*.{bam,cram,sam}" output: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - bai: - type: file - description: BAM/CRAM/SAM index file - pattern: "*.{bai,crai,sai}" - - crai: - type: file - description: BAM/CRAM/SAM index file - pattern: "*.{bai,crai,sai}" - - csi: - type: file - description: CSI index file - pattern: "*.{csi}" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - bai: + type: file + description: BAM/CRAM/SAM index file + pattern: "*.{bai,crai,sai}" + - crai: + type: file + description: BAM/CRAM/SAM index file + pattern: "*.{bai,crai,sai}" + - csi: + type: file + description: CSI index file + pattern: "*.{csi}" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@drpatelh" - - "@ewels" - - "@maxulysse" + - "@drpatelh" + - "@ewels" + - "@maxulysse" diff --git a/modules/nf-core/modules/samtools/sort/main.nf b/modules/nf-core/modules/samtools/sort/main.nf index 0c2cf25e3..0e2de8baa 100644 --- a/modules/nf-core/modules/samtools/sort/main.nf +++ b/modules/nf-core/modules/samtools/sort/main.nf @@ -2,10 +2,10 @@ process SAMTOOLS_SORT { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? "bioconda::samtools=1.14" : null) + conda (params.enable_conda ? "bioconda::samtools=1.15" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/samtools:1.14--hb421002_0' : - 'quay.io/biocontainers/samtools:1.14--hb421002_0' }" + 'https://depot.galaxyproject.org/singularity/samtools:1.15--h1170115_1' : + 'quay.io/biocontainers/samtools:1.15--h1170115_1' }" input: tuple val(meta), path(bam) @@ -14,9 +14,13 @@ process SAMTOOLS_SORT { tuple val(meta), path("*.bam"), emit: bam path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" + if ("$bam" == "${prefix}.bam") error "Input and output names are the same, use \"task.ext.prefix\" to disambiguate!" """ samtools sort $args -@ $task.cpus -o ${prefix}.bam -T $prefix $bam cat <<-END_VERSIONS > versions.yml diff --git a/modules/nf-core/modules/samtools/sort/meta.yml b/modules/nf-core/modules/samtools/sort/meta.yml index 3402a0680..a820c55a3 100644 --- a/modules/nf-core/modules/samtools/sort/meta.yml +++ b/modules/nf-core/modules/samtools/sort/meta.yml @@ -1,44 +1,44 @@ name: samtools_sort description: Sort SAM/BAM/CRAM file keywords: - - sort - - bam - - sam - - cram + - sort + - bam + - sam + - cram tools: - - samtools: - description: | - SAMtools is a set of utilities for interacting with and post-processing - short DNA sequence read alignments in the SAM, BAM and CRAM formats, written by Heng Li. - These files are generated as output by short read aligners like BWA. - homepage: http://www.htslib.org/ - documentation: hhttp://www.htslib.org/doc/samtools.html - doi: 10.1093/bioinformatics/btp352 - licence: ['MIT'] + - samtools: + description: | + SAMtools is a set of utilities for interacting with and post-processing + short DNA sequence read alignments in the SAM, BAM and CRAM formats, written by Heng Li. + These files are generated as output by short read aligners like BWA. + homepage: http://www.htslib.org/ + documentation: hhttp://www.htslib.org/doc/samtools.html + doi: 10.1093/bioinformatics/btp352 + licence: ["MIT"] input: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - bam: - type: file - description: BAM/CRAM/SAM file - pattern: "*.{bam,cram,sam}" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - bam: + type: file + description: BAM/CRAM/SAM file + pattern: "*.{bam,cram,sam}" output: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - bam: - type: file - description: Sorted BAM/CRAM/SAM file - pattern: "*.{bam,cram,sam}" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - bam: + type: file + description: Sorted BAM/CRAM/SAM file + pattern: "*.{bam,cram,sam}" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@drpatelh" - - "@ewels" + - "@drpatelh" + - "@ewels" diff --git a/modules/nf-core/modules/samtools/stats/main.nf b/modules/nf-core/modules/samtools/stats/main.nf index 83c870025..6efc9d9a5 100644 --- a/modules/nf-core/modules/samtools/stats/main.nf +++ b/modules/nf-core/modules/samtools/stats/main.nf @@ -2,10 +2,10 @@ process SAMTOOLS_STATS { tag "$meta.id" label 'process_low' - conda (params.enable_conda ? "bioconda::samtools=1.14" : null) + conda (params.enable_conda ? "bioconda::samtools=1.15" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/samtools:1.14--hb421002_0' : - 'quay.io/biocontainers/samtools:1.14--hb421002_0' }" + 'https://depot.galaxyproject.org/singularity/samtools:1.15--h1170115_1' : + 'quay.io/biocontainers/samtools:1.15--h1170115_1' }" input: tuple val(meta), path(input), path(input_index) @@ -15,11 +15,19 @@ process SAMTOOLS_STATS { tuple val(meta), path("*.stats"), emit: stats path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def reference = fasta ? "--reference ${fasta}" : "" """ - samtools stats --threads ${task.cpus-1} ${reference} ${input} > ${input}.stats + samtools \\ + stats \\ + --threads ${task.cpus-1} \\ + ${reference} \\ + ${input} \\ + > ${input}.stats cat <<-END_VERSIONS > versions.yml "${task.process}": diff --git a/modules/nf-core/modules/samtools/stats/meta.yml b/modules/nf-core/modules/samtools/stats/meta.yml index 869e62e37..cac50b1c0 100644 --- a/modules/nf-core/modules/samtools/stats/meta.yml +++ b/modules/nf-core/modules/samtools/stats/meta.yml @@ -1,53 +1,53 @@ name: samtools_stats description: Produces comprehensive statistics from SAM/BAM/CRAM file keywords: - - statistics - - counts - - bam - - sam - - cram + - statistics + - counts + - bam + - sam + - cram tools: - - samtools: - description: | - SAMtools is a set of utilities for interacting with and post-processing - short DNA sequence read alignments in the SAM, BAM and CRAM formats, written by Heng Li. - These files are generated as output by short read aligners like BWA. - homepage: http://www.htslib.org/ - documentation: hhttp://www.htslib.org/doc/samtools.html - doi: 10.1093/bioinformatics/btp352 - licence: ['MIT'] + - samtools: + description: | + SAMtools is a set of utilities for interacting with and post-processing + short DNA sequence read alignments in the SAM, BAM and CRAM formats, written by Heng Li. + These files are generated as output by short read aligners like BWA. + homepage: http://www.htslib.org/ + documentation: hhttp://www.htslib.org/doc/samtools.html + doi: 10.1093/bioinformatics/btp352 + licence: ["MIT"] input: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - input: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - input: + type: file + description: BAM/CRAM file from alignment + pattern: "*.{bam,cram}" + - input_index: + type: file + description: BAI/CRAI file from alignment + pattern: "*.{bai,crai}" + - fasta: + type: optional file + description: Reference file the CRAM was created with + pattern: "*.{fasta,fa}" +output: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - stats: type: file - description: BAM/CRAM file from alignment - pattern: "*.{bam,cram}" - - input_index: + description: File containing samtools stats output + pattern: "*.{stats}" + - versions: type: file - description: BAI/CRAI file from alignment - pattern: "*.{bai,crai}" - - fasta: - type: optional file - description: Reference file the CRAM was created with - pattern: "*.{fasta,fa}" -output: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - stats: - type: file - description: File containing samtools stats output - pattern: "*.{stats}" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + description: File containing software versions + pattern: "versions.yml" authors: - - "@drpatelh" - - "@FriederikeHanssen" + - "@drpatelh" + - "@FriederikeHanssen" diff --git a/modules/nf-core/modules/subread/featurecounts/main.nf b/modules/nf-core/modules/subread/featurecounts/main.nf index 53eb279e1..18e2a92bb 100644 --- a/modules/nf-core/modules/subread/featurecounts/main.nf +++ b/modules/nf-core/modules/subread/featurecounts/main.nf @@ -15,6 +15,9 @@ process SUBREAD_FEATURECOUNTS { tuple val(meta), path("*featureCounts.txt.summary"), emit: summary path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" diff --git a/modules/nf-core/modules/subread/featurecounts/meta.yml b/modules/nf-core/modules/subread/featurecounts/meta.yml index 1100a0914..cf02f1ea7 100644 --- a/modules/nf-core/modules/subread/featurecounts/meta.yml +++ b/modules/nf-core/modules/subread/featurecounts/meta.yml @@ -1,10 +1,10 @@ name: subread_featurecounts description: Count reads that map to genomic features keywords: - - counts - - fasta - - genome - - reference + - counts + - fasta + - genome + - reference tools: - featurecounts: @@ -12,14 +12,14 @@ tools: homepage: http://bioinf.wehi.edu.au/featureCounts/ documentation: http://bioinf.wehi.edu.au/subread-package/SubreadUsersGuide.pdf doi: "10.1093/bioinformatics/btt656" - licence: ['GPL v3'] + licence: ["GPL v3"] input: - meta: type: map description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] - bam: type: file description: BAM/SAM file containing read alignments @@ -33,8 +33,8 @@ output: - meta: type: map description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] - counts: type: file description: Counts of reads mapping to features diff --git a/modules/nf-core/modules/trimgalore/main.nf b/modules/nf-core/modules/trimgalore/main.nf index ee40b780b..9487c7990 100644 --- a/modules/nf-core/modules/trimgalore/main.nf +++ b/modules/nf-core/modules/trimgalore/main.nf @@ -18,6 +18,9 @@ process TRIMGALORE { tuple val(meta), path("*.html"), emit: html optional true tuple val(meta), path("*.zip") , emit: zip optional true + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' // Calculate number of --cores for TrimGalore based on value of task.cpus diff --git a/modules/nf-core/modules/trimgalore/meta.yml b/modules/nf-core/modules/trimgalore/meta.yml index c7e1df1de..e99a88334 100644 --- a/modules/nf-core/modules/trimgalore/meta.yml +++ b/modules/nf-core/modules/trimgalore/meta.yml @@ -1,59 +1,59 @@ name: trimgalore description: Trim FastQ files using Trim Galore! keywords: - - trimming - - adapters - - sequencing adapters - - fastq + - trimming + - adapters + - sequencing adapters + - fastq tools: - - trimgalore: - description: | - A wrapper tool around Cutadapt and FastQC to consistently apply quality - and adapter trimming to FastQ files, with some extra functionality for - MspI-digested RRBS-type (Reduced Representation Bisufite-Seq) libraries. - homepage: https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/ - documentation: https://github.com/FelixKrueger/TrimGalore/blob/master/Docs/Trim_Galore_User_Guide.md - licence: ['GPL-3.0-or-later'] + - trimgalore: + description: | + A wrapper tool around Cutadapt and FastQC to consistently apply quality + and adapter trimming to FastQ files, with some extra functionality for + MspI-digested RRBS-type (Reduced Representation Bisufite-Seq) libraries. + homepage: https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/ + documentation: https://github.com/FelixKrueger/TrimGalore/blob/master/Docs/Trim_Galore_User_Guide.md + licence: ["GPL-3.0-or-later"] input: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - reads: - type: file - description: | - List of input FastQ files of size 1 and 2 for single-end and paired-end data, - respectively. + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - reads: + type: file + description: | + List of input FastQ files of size 1 and 2 for single-end and paired-end data, + respectively. output: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - reads: - type: file - description: | - List of input adapter trimmed FastQ files of size 1 and 2 for - single-end and paired-end data, respectively. - pattern: "*.{fq.gz}" - - html: - type: file - description: FastQC report (optional) - pattern: "*_{fastqc.html}" - - zip: - type: file - description: FastQC report archive (optional) - pattern: "*_{fastqc.zip}" - - log: - type: file - description: Trim Galore! trimming report - pattern: "*_{report.txt}" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - reads: + type: file + description: | + List of input adapter trimmed FastQ files of size 1 and 2 for + single-end and paired-end data, respectively. + pattern: "*.{fq.gz}" + - html: + type: file + description: FastQC report (optional) + pattern: "*_{fastqc.html}" + - zip: + type: file + description: FastQC report archive (optional) + pattern: "*_{fastqc.zip}" + - log: + type: file + description: Trim Galore! trimming report + pattern: "*_{report.txt}" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@drpatelh" - - "@ewels" - - "@FelixKrueger" + - "@drpatelh" + - "@ewels" + - "@FelixKrueger" diff --git a/modules/nf-core/modules/ucsc/bedgraphtobigwig/main.nf b/modules/nf-core/modules/ucsc/bedgraphtobigwig/main.nf index 9ba306aba..ef0ca088f 100644 --- a/modules/nf-core/modules/ucsc/bedgraphtobigwig/main.nf +++ b/modules/nf-core/modules/ucsc/bedgraphtobigwig/main.nf @@ -17,6 +17,9 @@ process UCSC_BEDGRAPHTOBIGWIG { tuple val(meta), path("*.bigWig"), emit: bigwig path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" diff --git a/modules/nf-core/modules/untar/main.nf b/modules/nf-core/modules/untar/main.nf index 6d1996e77..bbae948aa 100644 --- a/modules/nf-core/modules/untar/main.nf +++ b/modules/nf-core/modules/untar/main.nf @@ -2,7 +2,7 @@ process UNTAR { tag "$archive" label 'process_low' - conda (params.enable_conda ? "conda-forge::sed=4.7" : null) + conda (params.enable_conda ? "conda-forge::tar=1.32" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? 'https://containers.biocontainers.pro/s3/SingImgsRepo/biocontainers/v1.2.0_cv1/biocontainers_v1.2.0_cv1.img' : 'biocontainers/biocontainers:v1.2.0_cv1' }" @@ -14,6 +14,9 @@ process UNTAR { path "$untar" , emit: untar path "versions.yml", emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' def args2 = task.ext.args2 ?: '' diff --git a/modules/nf-core/modules/untar/meta.yml b/modules/nf-core/modules/untar/meta.yml index 51f94995e..e877a97c1 100644 --- a/modules/nf-core/modules/untar/meta.yml +++ b/modules/nf-core/modules/untar/meta.yml @@ -1,28 +1,28 @@ name: untar description: Extract files. keywords: - - untar - - uncompress + - untar + - uncompress tools: - - untar: - description: | - Extract tar.gz files. - documentation: https://www.gnu.org/software/tar/manual/ - licence: ['GPL-3.0-or-later'] + - untar: + description: | + Extract tar.gz files. + documentation: https://www.gnu.org/software/tar/manual/ + licence: ["GPL-3.0-or-later"] input: - - archive: - type: file - description: File to be untar - pattern: "*.{tar}.{gz}" + - archive: + type: file + description: File to be untar + pattern: "*.{tar}.{gz}" output: - - untar: - type: file - description: - pattern: "*.*" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - untar: + type: file + description: + pattern: "*.*" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@joseespinosa" - - "@drpatelh" + - "@joseespinosa" + - "@drpatelh" diff --git a/subworkflows/nf-core/align_bwa_mem.nf b/subworkflows/nf-core/align_bwa_mem.nf index 297fd3504..0c5dff084 100644 --- a/subworkflows/nf-core/align_bwa_mem.nf +++ b/subworkflows/nf-core/align_bwa_mem.nf @@ -17,7 +17,7 @@ workflow ALIGN_BWA_MEM { // // Map reads with BWA // - BWA_MEM(reads, index) + BWA_MEM(reads, index, false) ch_versions = ch_versions.mix(BWA_MEM.out.versions.first()) // From e912404d3dfbcb1f20b45e79f650ccd06b5e2af9 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 7 Mar 2022 16:34:20 +0100 Subject: [PATCH 346/538] Make --outdir mandatory --- .github/PULL_REQUEST_TEMPLATE.md | 2 +- .github/workflows/awsfulltest.yml | 7 +++++++ .github/workflows/ci.yml | 10 ++++++---- CHANGELOG.md | 6 ++---- README.md | 3 ++- conf/modules.config | 8 ++++---- conf/test.config | 2 +- conf/test_full.config | 2 +- docs/usage.md | 2 +- lib/WorkflowMain.groovy | 2 +- nextflow.config | 2 +- nextflow_schema.json | 4 ++-- 12 files changed, 29 insertions(+), 21 deletions(-) diff --git a/.github/PULL_REQUEST_TEMPLATE.md b/.github/PULL_REQUEST_TEMPLATE.md index 2f5f69256..f0a3ff064 100644 --- a/.github/PULL_REQUEST_TEMPLATE.md +++ b/.github/PULL_REQUEST_TEMPLATE.md @@ -19,7 +19,7 @@ Learn more about contributing: [CONTRIBUTING.md](https://github.com/nf-core/chip - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) - [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. - [ ] Make sure your code lints (`nf-core lint`). -- [ ] Ensure the test suite passes (`nextflow run . -profile test,docker`). +- [ ] Ensure the test suite passes (`nextflow run . -profile test,docker --outdir `). - [ ] Usage Documentation in `docs/usage.md` is updated. - [ ] Output Documentation in `docs/output.md` is updated. - [ ] `CHANGELOG.md` is updated. diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index 3015ffe7a..6d200a5e5 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -12,6 +12,10 @@ jobs: name: Run AWS full tests if: github.repository == 'nf-core/chipseq' runs-on: ubuntu-latest + strategy: + matrix: + # aligner: ["bwa", "bowtie2", "chromap", "star"] //TODO uncomment when chromap implemented + aligner: ["bwa", "bowtie2", "star"] steps: - name: Launch workflow via tower uses: nf-core/tower-action@v3 @@ -19,10 +23,13 @@ jobs: workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }} access_token: ${{ secrets.TOWER_ACCESS_TOKEN }} compute_env: ${{ secrets.TOWER_COMPUTE_ENV }} + pipeline: ${{ github.repository }} + revision: ${{ github.sha }} workdir: s3://${{ secrets.AWS_S3_BUCKET }}/work/chipseq/work-${{ github.sha }} parameters: | { "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-${{ github.sha }}" + "aligner": "${{ matrix.aligner }}" } profiles: test_full,aws_tower nextflow_config: | diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index a47a74e65..25c505b02 100755 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -14,7 +14,7 @@ env: jobs: test: - name: Run workflow tests + name: Run pipeline with test data # Only run on push if this is the nf-core dev branch (merged PRs) if: ${{ github.event_name != 'push' || (github.event_name == 'push' && github.repository == 'nf-core/chipseq') }} runs-on: ubuntu-latest @@ -44,7 +44,8 @@ jobs: - name: Run pipeline with test data run: | - nextflow run ${GITHUB_WORKSPACE} -profile test,docker + nextflow run ${GITHUB_WORKSPACE} -profile test,docker --outdir ./results + parameters: name: Test workflow parameters @@ -66,7 +67,7 @@ jobs: - name: Run pipeline with various parameters run: | - nextflow run ${GITHUB_WORKSPACE} -profile test,docker ${{ matrix.parameters }} + nextflow run ${GITHUB_WORKSPACE} -profile test,docker ${{ matrix.parameters }} --outdir ./results aligners: name: Test available aligners @@ -76,6 +77,7 @@ jobs: matrix: aligner: - "bowtie2" + # - "chromap" #TODO uncomment when implemented - "star" steps: - name: Check out pipeline code @@ -88,4 +90,4 @@ jobs: - name: Run pipeline with the different aligners available run: | - nextflow run ${GITHUB_WORKSPACE} -profile test,docker --aligner ${{ matrix.aligner }} + nextflow run ${GITHUB_WORKSPACE} -profile test,docker --aligner ${{ matrix.aligner }} --outdir ./results diff --git a/CHANGELOG.md b/CHANGELOG.md index 8e496fce5..6573b686e 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -5,7 +5,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 ## [Unpublished Version / DEV] -### Major enhancements +### Enhancements & fixes * Port pipeline to the updated Nextflow DSL2 syntax adopted on nf-core/modules * Removed `--publish_dir_mode` as it is no longer required for the new syntax @@ -13,13 +13,11 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 * Updated pipeline template to [nf-core/tools 2.2](https://github.com/nf-core/tools/releases/tag/2.2) * Added `python3` shebang to appropriate scripts in `bin/` directory * [[#160](https://github.com/nf-core/chipseq/issues/160)] - Add `bowtie2` and `star` as available aligners, via the `--aligner` parameter - -### Other enhancements & fixes - * Update pipeline template to nf-core/tools `2.1` * Add `--save_unaligned` parameter (only available for `bowtie2` and `star`) * Update `igenomes.config` to fetch whole `BWAIndex/version0.6.0/` folder * [[228](https://github.com/nf-core/chipseq/issues/228)] - Update blacklist bed files. +* [nf-core/tools#1415](https://github.com/nf-core/tools/issues/1415) - Make `--outdir` a mandatory parameter ### Parameters diff --git a/README.md b/README.md index e31aa418b..fc1bf270d 100644 --- a/README.md +++ b/README.md @@ -63,7 +63,7 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool 3. Download the pipeline and test it on a minimal dataset with a single command: ```console - nextflow run nf-core/chipseq -profile test,YOURPROFILE + nextflow run nf-core/chipseq -profile test,YOURPROFILE --outdir ``` Note that some form of configuration will be needed so that Nextflow knows how to fetch the required software. This is usually done in the form of a config profile (`YOURPROFILE` in the example command above). You can chain multiple config profiles in a comma-separated string. @@ -78,6 +78,7 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool ```bash nextflow run nf-core/chipseq \ --input samplesheet.csv \ + --outdir \ --genome GRCh37 \ -profile ``` diff --git a/conf/modules.config b/conf/modules.config index bd17ccf3b..a20c6b09f 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -3,10 +3,10 @@ Config file for defining DSL2 per module options and publishing paths ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Available keys to override module options: - ext.args = Additional arguments appended to command in module. - ext.args2 = Second set of arguments appended to command in module (multi-tool modules). - ext.args3 = Third set of arguments appended to command in module (multi-tool modules). - ext.prefix = File name prefix for output files. + ext.args = Additional arguments appended to command in module. + ext.args2 = Second set of arguments appended to command in module (multi-tool modules). + ext.args3 = Third set of arguments appended to command in module (multi-tool modules). + ext.prefix = File name prefix for output files. --------------------------------------------------------------------------------------------------------- */ diff --git a/conf/test.config b/conf/test.config index 2afa57f66..d9c938a09 100644 --- a/conf/test.config +++ b/conf/test.config @@ -5,7 +5,7 @@ Defines input files and everything required to run a fast and simple pipeline test. Use as follows: - nextflow run nf-core/chipseq -profile test, + nextflow run nf-core/chipseq -profile test, --outdir ---------------------------------------------------------------------------------------- */ diff --git a/conf/test_full.config b/conf/test_full.config index 66bac3050..de6120539 100644 --- a/conf/test_full.config +++ b/conf/test_full.config @@ -5,7 +5,7 @@ Defines input files and everything required to run a full size pipeline test. Use as follows: - nextflow run nf-core/chipseq -profile test_full, + nextflow run nf-core/chipseq -profile test_full, --outdir ---------------------------------------------------------------------------------------- */ diff --git a/docs/usage.md b/docs/usage.md index 89423dc36..425066f35 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -117,7 +117,7 @@ wget -L https://www.encodeproject.org/files/ENCFF356LFX/@@download/ENCFF356LFX.b The typical command for running the pipeline is as follows: ```console -nextflow run nf-core/chipseq --input samplesheet.csv --genome GRCh37 -profile docker +nextflow run nf-core/chipseq --input samplesheet.csv --outdir --genome GRCh37 -profile docker ``` This will launch the pipeline with the `docker` configuration profile. See below for more information about profiles. diff --git a/lib/WorkflowMain.groovy b/lib/WorkflowMain.groovy index 3ebf7521c..e17aadd9d 100755 --- a/lib/WorkflowMain.groovy +++ b/lib/WorkflowMain.groovy @@ -21,7 +21,7 @@ class WorkflowMain { // Print help to screen if required // public static String help(workflow, params, log) { - def command = "nextflow run ${workflow.manifest.name} --input samplesheet.csv --genome GRCh37 -profile docker" + def command = "nextflow run ${workflow.manifest.name} --input samplesheet.csv --outdir --genome GRCh37 -profile docker" def help_string = '' help_string += NfcoreTemplate.logo(workflow, params.monochrome_logs) help_string += NfcoreSchema.paramsHelp(workflow, params, command) diff --git a/nextflow.config b/nextflow.config index f11ad56ab..f68ef6f6a 100644 --- a/nextflow.config +++ b/nextflow.config @@ -74,7 +74,7 @@ params { max_multiqc_email_size = '25.MB' // Boilerplate options - outdir = './results' + outdir = null tracedir = "${params.outdir}/pipeline_info" publish_dir_mode = 'copy' email = null diff --git a/nextflow_schema.json b/nextflow_schema.json index cf98ed2d8..34825a35b 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -37,8 +37,8 @@ }, "outdir": { "type": "string", - "description": "Path to the output directory where the results will be saved.", - "default": "./results", + "format": "directory-path", + "description": "The output directory where the results will be saved. You have to use absolute paths to storage on Cloud infrastructure.", "fa_icon": "fas fa-folder-open" }, "email": { From 3cab81d689110a7b9f0b7e48212430e8a7e8e385 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 7 Mar 2022 17:14:15 +0100 Subject: [PATCH 347/538] Delete deprecated blacklist files --- assets/blacklists/old/GRCm38-blacklist.bed | 164 --------------------- assets/blacklists/old/hg38-blacklist.bed | 38 ----- assets/blacklists/old/mm10-blacklist.bed | 164 --------------------- mm10-blacklist.bed | 164 --------------------- 4 files changed, 530 deletions(-) delete mode 100755 assets/blacklists/old/GRCm38-blacklist.bed delete mode 100644 assets/blacklists/old/hg38-blacklist.bed delete mode 100755 assets/blacklists/old/mm10-blacklist.bed delete mode 100755 mm10-blacklist.bed diff --git a/assets/blacklists/old/GRCm38-blacklist.bed b/assets/blacklists/old/GRCm38-blacklist.bed deleted file mode 100755 index 3699d020a..000000000 --- a/assets/blacklists/old/GRCm38-blacklist.bed +++ /dev/null @@ -1,164 +0,0 @@ -10 3110060 3110270 -10 22142530 22142880 -10 22142830 22143070 -10 58223870 58224100 -10 58225260 58225500 -10 58228320 58228520 -11 3148660 3148860 -11 3154960 3155170 -11 3158530 3158750 -11 3161780 3161990 -11 3167020 3167250 -11 3169390 3169620 -11 3172450 3172670 -11 3172950 3173190 -11 3184190 3185750 -11 3185700 3186360 -11 3186330 3189230 -11 3189190 3190740 -11 3190750 3191000 -11 3190960 3194430 -11 3194400 3195310 -11 3195240 3197220 -11 3197340 3197950 -11 3197890 3198700 -11 3198630 3199440 -11 3199350 3200120 -11 54139940 54140230 -11 54140470 54140740 -11 88967720 88969600 -11 88969850 88970350 -11 109011550 109012090 -12 3109920 3110150 -12 105436040 105436270 -13 3372960 3373380 -13 3373410 3373630 -13 77438870 77439090 -13 97190460 97190690 -13 99790830 99791090 -13 119488570 119489320 -13 119597600 119598320 -13 119599860 119600050 -13 119601360 119601600 -13 119601800 119602210 -13 119602360 119602580 -13 119609430 119611430 -13 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JoseEspinosa Date: Mon, 7 Mar 2022 17:14:26 +0100 Subject: [PATCH 348/538] Make nf-core lint happy --- .nf-core.yml | 1 + 1 file changed, 1 insertion(+) diff --git a/.nf-core.yml b/.nf-core.yml index aca9e11fa..1e3aafb1f 100644 --- a/.nf-core.yml +++ b/.nf-core.yml @@ -10,5 +10,6 @@ lint: - .github/workflows/branch.yml - .github/workflows/linting_comment.yml - .github/workflows/linting.yml + - .github/PULL_REQUEST_TEMPLATE.md repository_type: pipeline From 10573c6d2c8c280bc6de4e6c19cb41d64a98a322 Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Tue, 15 Mar 2022 20:58:19 +0000 Subject: [PATCH 349/538] Template update for nf-core/tools version 2.3 --- .github/ISSUE_TEMPLATE/bug_report.yml | 1 - .github/PULL_REQUEST_TEMPLATE.md | 2 +- .github/workflows/awsfulltest.yml | 6 +- .github/workflows/awstest.yml | 6 +- .github/workflows/ci.yml | 4 +- .github/workflows/linting.yml | 28 +- .gitpod.yml | 14 + .nf-core.yml | 1 + .yamllint.yml | 6 + LICENSE | 2 +- README.md | 8 +- bin/check_samplesheet.py | 346 ++++++++++++++------- conf/base.config | 4 +- conf/igenomes.config | 80 ++--- conf/modules.config | 18 +- conf/test.config | 6 +- conf/test_full.config | 6 +- docs/images/nf-core-chipseq_logo_light.png | Bin 428 -> 73788 bytes docs/usage.md | 21 +- lib/NfcoreSchema.groovy | 4 +- lib/Utils.groovy | 4 +- lib/WorkflowChipseq.groovy | 4 +- main.nf | 24 +- nextflow.config | 20 +- nextflow_schema.json | 23 +- subworkflows/local/input_check.nf | 18 +- workflows/chipseq.nf | 28 +- 27 files changed, 422 insertions(+), 262 deletions(-) create mode 100644 .gitpod.yml create mode 100644 .nf-core.yml create mode 100644 .yamllint.yml diff --git a/.github/ISSUE_TEMPLATE/bug_report.yml b/.github/ISSUE_TEMPLATE/bug_report.yml index b0d2788d9..ecfb25027 100644 --- a/.github/ISSUE_TEMPLATE/bug_report.yml +++ b/.github/ISSUE_TEMPLATE/bug_report.yml @@ -1,4 +1,3 @@ - name: Bug report description: Report something that is broken or incorrect labels: bug diff --git a/.github/PULL_REQUEST_TEMPLATE.md b/.github/PULL_REQUEST_TEMPLATE.md index 2f5f69256..88c55b84f 100644 --- a/.github/PULL_REQUEST_TEMPLATE.md +++ b/.github/PULL_REQUEST_TEMPLATE.md @@ -19,7 +19,7 @@ Learn more about contributing: [CONTRIBUTING.md](https://github.com/nf-core/chip - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) - [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. - [ ] Make sure your code lints (`nf-core lint`). -- [ ] Ensure the test suite passes (`nextflow run . -profile test,docker`). +- [ ] Ensure the test suite passes (`nextflow run . -profile test,docker` --outdir `). - [ ] Usage Documentation in `docs/usage.md` is updated. - [ ] Output Documentation in `docs/output.md` is updated. - [ ] `CHANGELOG.md` is updated. diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index a5e2cade9..c0851d163 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -14,7 +14,7 @@ jobs: runs-on: ubuntu-latest steps: - name: Launch workflow via tower - uses: nf-core/tower-action@v2 + uses: nf-core/tower-action@v3 # TODO nf-core: You can customise AWS full pipeline tests as required # Add full size test data (but still relatively small datasets for few samples) # on the `test_full.config` test runs with only one set of parameters @@ -31,4 +31,6 @@ jobs: "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-${{ github.sha }}" } profiles: test_full,aws_tower - pre_run_script: 'export NXF_VER=21.10.3' + nextflow_config: | + process.errorStrategy = 'retry' + process.maxRetries = 3 diff --git a/.github/workflows/awstest.yml b/.github/workflows/awstest.yml index b8f720cbe..02bd219ef 100644 --- a/.github/workflows/awstest.yml +++ b/.github/workflows/awstest.yml @@ -11,7 +11,7 @@ jobs: runs-on: ubuntu-latest steps: - name: Launch workflow via tower - uses: nf-core/tower-action@v2 + uses: nf-core/tower-action@v3 with: workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }} @@ -25,4 +25,6 @@ jobs: "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-test-${{ github.sha }}" } profiles: test,aws_tower - pre_run_script: 'export NXF_VER=21.10.3' + nextflow_config: | + process.errorStrategy = 'retry' + process.maxRetries = 3 diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 57b49cfac..d8f2c0e5f 100644 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -14,7 +14,7 @@ env: jobs: test: - name: Run workflow tests + name: Run pipeline with test data # Only run on push if this is the nf-core dev branch (merged PRs) if: ${{ github.event_name != 'push' || (github.event_name == 'push' && github.repository == 'nf-core/chipseq') }} runs-on: ubuntu-latest @@ -47,4 +47,4 @@ jobs: # For example: adding multiple test runs with different parameters # Remember that you can parallelise this by using strategy.matrix run: | - nextflow run ${GITHUB_WORKSPACE} -profile test,docker + nextflow run ${GITHUB_WORKSPACE} -profile test,docker --outdir ./results diff --git a/.github/workflows/linting.yml b/.github/workflows/linting.yml index 3b448773c..fda934c03 100644 --- a/.github/workflows/linting.yml +++ b/.github/workflows/linting.yml @@ -12,9 +12,7 @@ jobs: runs-on: ubuntu-latest steps: - uses: actions/checkout@v2 - - uses: actions/setup-node@v1 - with: - node-version: '10' + - uses: actions/setup-node@v2 - name: Install markdownlint run: npm install -g markdownlint-cli - name: Run Markdownlint @@ -51,9 +49,7 @@ jobs: steps: - uses: actions/checkout@v2 - - uses: actions/setup-node@v1 - with: - node-version: '10' + - uses: actions/setup-node@v2 - name: Install editorconfig-checker run: npm install -g editorconfig-checker @@ -64,14 +60,13 @@ jobs: YAML: runs-on: ubuntu-latest steps: - - uses: actions/checkout@v1 - - uses: actions/setup-node@v1 + - name: Checkout + uses: actions/checkout@master + - name: 'Yamllint' + uses: karancode/yamllint-github-action@master with: - node-version: '10' - - name: Install yaml-lint - run: npm install -g yaml-lint - - name: Run yaml-lint - run: yamllint $(find ${GITHUB_WORKSPACE} -type f -name "*.yml" -o -name "*.yaml") + yamllint_file_or_dir: '.' + yamllint_config_filepath: '.yamllint.yml' # If the above check failed, post a comment on the PR explaining the failure - name: Post PR comment @@ -84,10 +79,11 @@ jobs: To keep the code consistent with lots of contributors, we run automated code consistency checks. To fix this CI test, please run: - * Install `yaml-lint` - * [Install `npm`](https://www.npmjs.com/get-npm) then [install `yaml-lint`](https://www.npmjs.com/package/yaml-lint) (`npm install -g yaml-lint`) + * Install `yamllint` + * Install `yamllint` following [this](https://yamllint.readthedocs.io/en/stable/quickstart.html#installing-yamllint) + instructions or alternative install it in your [conda environment](https://anaconda.org/conda-forge/yamllint) * Fix the markdown errors - * Run the test locally: `yamllint $(find . -type f -name "*.yml" -o -name "*.yaml")` + * Run the test locally: `yamllint $(find . -type f -name "*.yml" -o -name "*.yaml") -c ./.yamllint.yml` * Fix any reported errors in your YAML files Once you push these changes the test should pass, and you can hide this comment :+1: diff --git a/.gitpod.yml b/.gitpod.yml new file mode 100644 index 000000000..b7d4cee18 --- /dev/null +++ b/.gitpod.yml @@ -0,0 +1,14 @@ +image: nfcore/gitpod:latest + +vscode: + extensions: # based on nf-core.nf-core-extensionpack + - codezombiech.gitignore # Language support for .gitignore files + # - cssho.vscode-svgviewer # SVG viewer + - davidanson.vscode-markdownlint # Markdown/CommonMark linting and style checking for Visual Studio Code + - eamodio.gitlens # Quickly glimpse into whom, why, and when a line or code block was changed + - EditorConfig.EditorConfig # override user/workspace settings with settings found in .editorconfig files + - Gruntfuggly.todo-tree # Display TODO and FIXME in a tree view in the activity bar + - mechatroner.rainbow-csv # Highlight columns in csv files in different colors + # - nextflow.nextflow # Nextflow syntax highlighting + - oderwat.indent-rainbow # Highlight indentation level + - streetsidesoftware.code-spell-checker # Spelling checker for source code diff --git a/.nf-core.yml b/.nf-core.yml new file mode 100644 index 000000000..3805dc81c --- /dev/null +++ b/.nf-core.yml @@ -0,0 +1 @@ +repository_type: pipeline diff --git a/.yamllint.yml b/.yamllint.yml new file mode 100644 index 000000000..d466deec9 --- /dev/null +++ b/.yamllint.yml @@ -0,0 +1,6 @@ +extends: default + +rules: + document-start: disable + line-length: disable + truthy: disable diff --git a/LICENSE b/LICENSE index 2a0f576bc..e6309f574 100644 --- a/LICENSE +++ b/LICENSE @@ -1,6 +1,6 @@ MIT License -Copyright (c) Philip Ewels +Copyright (c) Philip Ewels, Jose Espinosa-Carrasco, Harshil Patel Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal diff --git a/README.md b/README.md index 5dcdd654d..28d5f8bec 100644 --- a/README.md +++ b/README.md @@ -40,14 +40,14 @@ On release, automated continuous integration tests run the pipeline on a full-si 3. Download the pipeline and test it on a minimal dataset with a single command: ```console - nextflow run nf-core/chipseq -profile test,YOURPROFILE + nextflow run nf-core/chipseq -profile test,YOURPROFILE --outdir ``` Note that some form of configuration will be needed so that Nextflow knows how to fetch the required software. This is usually done in the form of a config profile (`YOURPROFILE` in the example command above). You can chain multiple config profiles in a comma-separated string. > * The pipeline comes with config profiles called `docker`, `singularity`, `podman`, `shifter`, `charliecloud` and `conda` which instruct the pipeline to use the named tool for software management. For example, `-profile test,docker`. > * Please check [nf-core/configs](https://github.com/nf-core/configs#documentation) to see if a custom config file to run nf-core pipelines already exists for your Institute. If so, you can simply use `-profile ` in your command. This will enable either `docker` or `singularity` and set the appropriate execution settings for your local compute environment. - > * If you are using `singularity` and are persistently observing issues downloading Singularity images directly due to timeout or network issues, then you can use the `--singularity_pull_docker_container` parameter to pull and convert the Docker image instead. Alternatively, you can use the [`nf-core download`](https://nf-co.re/tools/#downloading-pipelines-for-offline-use) command to download images first, before running the pipeline. Setting the [`NXF_SINGULARITY_CACHEDIR` or `singularity.cacheDir`](https://www.nextflow.io/docs/latest/singularity.html?#singularity-docker-hub) Nextflow options enables you to store and re-use the images from a central location for future pipeline runs. + > * If you are using `singularity`, please use the [`nf-core download`](https://nf-co.re/tools/#downloading-pipelines-for-offline-use) command to download images first, before running the pipeline. Setting the [`NXF_SINGULARITY_CACHEDIR` or `singularity.cacheDir`](https://www.nextflow.io/docs/latest/singularity.html?#singularity-docker-hub) Nextflow options enables you to store and re-use the images from a central location for future pipeline runs. > * If you are using `conda`, it is highly recommended to use the [`NXF_CONDA_CACHEDIR` or `conda.cacheDir`](https://www.nextflow.io/docs/latest/conda.html) settings to store the environments in a central location for future pipeline runs. 4. Start running your own analysis! @@ -55,7 +55,7 @@ On release, automated continuous integration tests run the pipeline on a full-si ```console - nextflow run nf-core/chipseq -profile --input samplesheet.csv --genome GRCh37 + nextflow run nf-core/chipseq --input samplesheet.csv --outdir --genome GRCh37 -profile ``` ## Documentation @@ -64,7 +64,7 @@ The nf-core/chipseq pipeline comes with documentation about the pipeline [usage] ## Credits -nf-core/chipseq was originally written by Philip Ewels. +nf-core/chipseq was originally written by Philip Ewels, Jose Espinosa-Carrasco, Harshil Patel. We thank the following people for their extensive assistance in the development of this pipeline: diff --git a/bin/check_samplesheet.py b/bin/check_samplesheet.py index a47ce7e57..5473b624c 100755 --- a/bin/check_samplesheet.py +++ b/bin/check_samplesheet.py @@ -1,145 +1,249 @@ #!/usr/bin/env python -# TODO nf-core: Update the script to check the samplesheet -# This script is based on the example at: https://raw.githubusercontent.com/nf-core/test-datasets/viralrecon/samplesheet/samplesheet_test_illumina_amplicon.csv -import os -import sys -import errno +"""Provide a command line tool to validate and transform tabular samplesheets.""" + + import argparse +import csv +import logging +import sys +from collections import Counter +from pathlib import Path -def parse_args(args=None): - Description = "Reformat nf-core/chipseq samplesheet file and check its contents." - Epilog = "Example usage: python check_samplesheet.py " +logger = logging.getLogger() - parser = argparse.ArgumentParser(description=Description, epilog=Epilog) - parser.add_argument("FILE_IN", help="Input samplesheet file.") - parser.add_argument("FILE_OUT", help="Output file.") - return parser.parse_args(args) +class RowChecker: + """ + Define a service that can validate and transform each given row. -def make_dir(path): - if len(path) > 0: - try: - os.makedirs(path) - except OSError as exception: - if exception.errno != errno.EEXIST: - raise exception + Attributes: + modified (list): A list of dicts, where each dict corresponds to a previously + validated and transformed row. The order of rows is maintained. + """ -def print_error(error, context="Line", context_str=""): - error_str = "ERROR: Please check samplesheet -> {}".format(error) - if context != "" and context_str != "": - error_str = "ERROR: Please check samplesheet -> {}\n{}: '{}'".format( - error, context.strip(), context_str.strip() + VALID_FORMATS = ( + ".fq.gz", + ".fastq.gz", + ) + + def __init__( + self, + sample_col="sample", + first_col="fastq_1", + second_col="fastq_2", + single_col="single_end", + **kwargs, + ): + """ + Initialize the row checker with the expected column names. + + Args: + sample_col (str): The name of the column that contains the sample name + (default "sample"). + first_col (str): The name of the column that contains the first (or only) + FASTQ file path (default "fastq_1"). + second_col (str): The name of the column that contains the second (if any) + FASTQ file path (default "fastq_2"). + single_col (str): The name of the new column that will be inserted and + records whether the sample contains single- or paired-end sequencing + reads (default "single_end"). + + """ + super().__init__(**kwargs) + self._sample_col = sample_col + self._first_col = first_col + self._second_col = second_col + self._single_col = single_col + self._seen = set() + self.modified = [] + + def validate_and_transform(self, row): + """ + Perform all validations on the given row and insert the read pairing status. + + Args: + row (dict): A mapping from column headers (keys) to elements of that row + (values). + + """ + self._validate_sample(row) + self._validate_first(row) + self._validate_second(row) + self._validate_pair(row) + self._seen.add((row[self._sample_col], row[self._first_col])) + self.modified.append(row) + + def _validate_sample(self, row): + """Assert that the sample name exists and convert spaces to underscores.""" + assert len(row[self._sample_col]) > 0, "Sample input is required." + # Sanitize samples slightly. + row[self._sample_col] = row[self._sample_col].replace(" ", "_") + + def _validate_first(self, row): + """Assert that the first FASTQ entry is non-empty and has the right format.""" + assert len(row[self._first_col]) > 0, "At least the first FASTQ file is required." + self._validate_fastq_format(row[self._first_col]) + + def _validate_second(self, row): + """Assert that the second FASTQ entry has the right format if it exists.""" + if len(row[self._second_col]) > 0: + self._validate_fastq_format(row[self._second_col]) + + def _validate_pair(self, row): + """Assert that read pairs have the same file extension. Report pair status.""" + if row[self._first_col] and row[self._second_col]: + row[self._single_col] = False + assert ( + Path(row[self._first_col]).suffixes == Path(row[self._second_col]).suffixes + ), "FASTQ pairs must have the same file extensions." + else: + row[self._single_col] = True + + def _validate_fastq_format(self, filename): + """Assert that a given filename has one of the expected FASTQ extensions.""" + assert any(filename.endswith(extension) for extension in self.VALID_FORMATS), ( + f"The FASTQ file has an unrecognized extension: {filename}\n" + f"It should be one of: {', '.join(self.VALID_FORMATS)}" ) - print(error_str) - sys.exit(1) + def validate_unique_samples(self): + """ + Assert that the combination of sample name and FASTQ filename is unique. + + In addition to the validation, also rename the sample if more than one sample, + FASTQ file combination exists. + + """ + assert len(self._seen) == len(self.modified), "The pair of sample name and FASTQ must be unique." + if len({pair[0] for pair in self._seen}) < len(self._seen): + counts = Counter(pair[0] for pair in self._seen) + seen = Counter() + for row in self.modified: + sample = row[self._sample_col] + seen[sample] += 1 + if counts[sample] > 1: + row[self._sample_col] = f"{sample}_T{seen[sample]}" + + +def sniff_format(handle): + """ + Detect the tabular format. + + Args: + handle (text file): A handle to a `text file`_ object. The read position is + expected to be at the beginning (index 0). + + Returns: + csv.Dialect: The detected tabular format. + + .. _text file: + https://docs.python.org/3/glossary.html#term-text-file -# TODO nf-core: Update the check_samplesheet function -def check_samplesheet(file_in, file_out): """ - This function checks that the samplesheet follows the following structure: + peek = handle.read(2048) + sniffer = csv.Sniffer() + if not sniffer.has_header(peek): + logger.critical(f"The given sample sheet does not appear to contain a header.") + sys.exit(1) + dialect = sniffer.sniff(peek) + handle.seek(0) + return dialect - sample,fastq_1,fastq_2 - SAMPLE_PE,SAMPLE_PE_RUN1_1.fastq.gz,SAMPLE_PE_RUN1_2.fastq.gz - SAMPLE_PE,SAMPLE_PE_RUN2_1.fastq.gz,SAMPLE_PE_RUN2_2.fastq.gz - SAMPLE_SE,SAMPLE_SE_RUN1_1.fastq.gz, - For an example see: - https://raw.githubusercontent.com/nf-core/test-datasets/viralrecon/samplesheet/samplesheet_test_illumina_amplicon.csv +def check_samplesheet(file_in, file_out): """ + Check that the tabular samplesheet has the structure expected by nf-core pipelines. - sample_mapping_dict = {} - with open(file_in, "r") as fin: + Validate the general shape of the table, expected columns, and each row. Also add + an additional column which records whether one or two FASTQ reads were found. - ## Check header - MIN_COLS = 2 - # TODO nf-core: Update the column names for the input samplesheet - HEADER = ["sample", "fastq_1", "fastq_2"] - header = [x.strip('"') for x in fin.readline().strip().split(",")] - if header[: len(HEADER)] != HEADER: - print("ERROR: Please check samplesheet header -> {} != {}".format(",".join(header), ",".join(HEADER))) - sys.exit(1) + Args: + file_in (pathlib.Path): The given tabular samplesheet. The format can be either + CSV, TSV, or any other format automatically recognized by ``csv.Sniffer``. + file_out (pathlib.Path): Where the validated and transformed samplesheet should + be created; always in CSV format. - ## Check sample entries - for line in fin: - lspl = [x.strip().strip('"') for x in line.strip().split(",")] - - # Check valid number of columns per row - if len(lspl) < len(HEADER): - print_error( - "Invalid number of columns (minimum = {})!".format(len(HEADER)), - "Line", - line, - ) - num_cols = len([x for x in lspl if x]) - if num_cols < MIN_COLS: - print_error( - "Invalid number of populated columns (minimum = {})!".format(MIN_COLS), - "Line", - line, - ) - - ## Check sample name entries - sample, fastq_1, fastq_2 = lspl[: len(HEADER)] - sample = sample.replace(" ", "_") - if not sample: - print_error("Sample entry has not been specified!", "Line", line) - - ## Check FastQ file extension - for fastq in [fastq_1, fastq_2]: - if fastq: - if fastq.find(" ") != -1: - print_error("FastQ file contains spaces!", "Line", line) - if not fastq.endswith(".fastq.gz") and not fastq.endswith(".fq.gz"): - print_error( - "FastQ file does not have extension '.fastq.gz' or '.fq.gz'!", - "Line", - line, - ) - - ## Auto-detect paired-end/single-end - sample_info = [] ## [single_end, fastq_1, fastq_2] - if sample and fastq_1 and fastq_2: ## Paired-end short reads - sample_info = ["0", fastq_1, fastq_2] - elif sample and fastq_1 and not fastq_2: ## Single-end short reads - sample_info = ["1", fastq_1, fastq_2] - else: - print_error("Invalid combination of columns provided!", "Line", line) - - ## Create sample mapping dictionary = { sample: [ single_end, fastq_1, fastq_2 ] } - if sample not in sample_mapping_dict: - sample_mapping_dict[sample] = [sample_info] - else: - if sample_info in sample_mapping_dict[sample]: - print_error("Samplesheet contains duplicate rows!", "Line", line) - else: - sample_mapping_dict[sample].append(sample_info) - - ## Write validated samplesheet with appropriate columns - if len(sample_mapping_dict) > 0: - out_dir = os.path.dirname(file_out) - make_dir(out_dir) - with open(file_out, "w") as fout: - fout.write(",".join(["sample", "single_end", "fastq_1", "fastq_2"]) + "\n") - for sample in sorted(sample_mapping_dict.keys()): - - ## Check that multiple runs of the same sample are of the same datatype - if not all(x[0] == sample_mapping_dict[sample][0][0] for x in sample_mapping_dict[sample]): - print_error("Multiple runs of a sample must be of the same datatype!", "Sample: {}".format(sample)) - - for idx, val in enumerate(sample_mapping_dict[sample]): - fout.write(",".join(["{}_T{}".format(sample, idx + 1)] + val) + "\n") - else: - print_error("No entries to process!", "Samplesheet: {}".format(file_in)) - - -def main(args=None): - args = parse_args(args) - check_samplesheet(args.FILE_IN, args.FILE_OUT) + Example: + This function checks that the samplesheet follows the following structure, + see also the `viral recon samplesheet`_:: + + sample,fastq_1,fastq_2 + SAMPLE_PE,SAMPLE_PE_RUN1_1.fastq.gz,SAMPLE_PE_RUN1_2.fastq.gz + SAMPLE_PE,SAMPLE_PE_RUN2_1.fastq.gz,SAMPLE_PE_RUN2_2.fastq.gz + SAMPLE_SE,SAMPLE_SE_RUN1_1.fastq.gz, + + .. _viral recon samplesheet: + https://raw.githubusercontent.com/nf-core/test-datasets/viralrecon/samplesheet/samplesheet_test_illumina_amplicon.csv + + """ + required_columns = {"sample", "fastq_1", "fastq_2"} + # See https://docs.python.org/3.9/library/csv.html#id3 to read up on `newline=""`. + with file_in.open(newline="") as in_handle: + reader = csv.DictReader(in_handle, dialect=sniff_format(in_handle)) + # Validate the existence of the expected header columns. + if not required_columns.issubset(reader.fieldnames): + logger.critical(f"The sample sheet **must** contain the column headers: {', '.join(required_columns)}.") + sys.exit(1) + # Validate each row. + checker = RowChecker() + for i, row in enumerate(reader): + try: + checker.validate_and_transform(row) + except AssertionError as error: + logger.critical(f"{str(error)} On line {i + 2}.") + sys.exit(1) + checker.validate_unique_samples() + header = list(reader.fieldnames) + header.insert(1, "single_end") + # See https://docs.python.org/3.9/library/csv.html#id3 to read up on `newline=""`. + with file_out.open(mode="w", newline="") as out_handle: + writer = csv.DictWriter(out_handle, header, delimiter=",") + writer.writeheader() + for row in checker.modified: + writer.writerow(row) + + +def parse_args(argv=None): + """Define and immediately parse command line arguments.""" + parser = argparse.ArgumentParser( + description="Validate and transform a tabular samplesheet.", + epilog="Example: python check_samplesheet.py samplesheet.csv samplesheet.valid.csv", + ) + parser.add_argument( + "file_in", + metavar="FILE_IN", + type=Path, + help="Tabular input samplesheet in CSV or TSV format.", + ) + parser.add_argument( + "file_out", + metavar="FILE_OUT", + type=Path, + help="Transformed output samplesheet in CSV format.", + ) + parser.add_argument( + "-l", + "--log-level", + help="The desired log level (default WARNING).", + choices=("CRITICAL", "ERROR", "WARNING", "INFO", "DEBUG"), + default="WARNING", + ) + return parser.parse_args(argv) + + +def main(argv=None): + """Coordinate argument parsing and program execution.""" + args = parse_args(argv) + logging.basicConfig(level=args.log_level, format="[%(levelname)s] %(message)s") + if not args.file_in.is_file(): + logger.error(f"The given input file {args.file_in} was not found!") + sys.exit(2) + args.file_out.parent.mkdir(parents=True, exist_ok=True) + check_samplesheet(args.file_in, args.file_out) if __name__ == "__main__": diff --git a/conf/base.config b/conf/base.config index 07779064b..8231c4796 100644 --- a/conf/base.config +++ b/conf/base.config @@ -1,7 +1,7 @@ /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ nf-core/chipseq Nextflow base config file -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ A 'blank slate' config file, appropriate for general use on most high performance compute environments. Assumes that all software is installed and available on the PATH. Runs in `local` mode - all jobs will be run on the logged in environment. diff --git a/conf/igenomes.config b/conf/igenomes.config index 855948def..7a1b3ac6d 100644 --- a/conf/igenomes.config +++ b/conf/igenomes.config @@ -1,7 +1,7 @@ /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Nextflow config file for iGenomes paths -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Defines reference genomes using iGenome paths. Can be used by any config that customises the base path using: $params.igenomes_base / --igenomes_base @@ -13,7 +13,7 @@ params { genomes { 'GRCh37' { fasta = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Sequence/BismarkIndex/" @@ -26,7 +26,7 @@ params { } 'GRCh38' { fasta = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/BismarkIndex/" @@ -38,7 +38,7 @@ params { } 'GRCm38' { fasta = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/BismarkIndex/" @@ -51,7 +51,7 @@ params { } 'TAIR10' { fasta = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/BismarkIndex/" @@ -62,7 +62,7 @@ params { } 'EB2' { fasta = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/BismarkIndex/" @@ -72,7 +72,7 @@ params { } 'UMD3.1' { fasta = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/BismarkIndex/" @@ -83,7 +83,7 @@ params { } 'WBcel235' { fasta = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/BismarkIndex/" @@ -94,7 +94,7 @@ params { } 'CanFam3.1' { fasta = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/BismarkIndex/" @@ -105,7 +105,7 @@ params { } 'GRCz10' { fasta = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/BismarkIndex/" @@ -115,7 +115,7 @@ params { } 'BDGP6' { fasta = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/BismarkIndex/" @@ -126,7 +126,7 @@ params { } 'EquCab2' { fasta = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/BismarkIndex/" @@ -137,7 +137,7 @@ params { } 'EB1' { fasta = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/BismarkIndex/" @@ -147,7 +147,7 @@ params { } 'Galgal4' { fasta = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/BismarkIndex/" @@ -157,7 +157,7 @@ params { } 'Gm01' { fasta = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/BismarkIndex/" @@ -167,7 +167,7 @@ params { } 'Mmul_1' { fasta = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/BismarkIndex/" @@ -178,7 +178,7 @@ params { } 'IRGSP-1.0' { fasta = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/BismarkIndex/" @@ -188,7 +188,7 @@ params { } 'CHIMP2.1.4' { fasta = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/BismarkIndex/" @@ -199,7 +199,7 @@ params { } 'Rnor_5.0' { fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/BismarkIndex/" @@ -209,7 +209,7 @@ params { } 'Rnor_6.0' { fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/BismarkIndex/" @@ -219,7 +219,7 @@ params { } 'R64-1-1' { fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/BismarkIndex/" @@ -230,7 +230,7 @@ params { } 'EF2' { fasta = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/BismarkIndex/" @@ -242,7 +242,7 @@ params { } 'Sbi1' { fasta = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/BismarkIndex/" @@ -252,7 +252,7 @@ params { } 'Sscrofa10.2' { fasta = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/BismarkIndex/" @@ -263,7 +263,7 @@ params { } 'AGPv3' { fasta = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/BismarkIndex/" @@ -273,7 +273,7 @@ params { } 'hg38' { fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/BismarkIndex/" @@ -285,7 +285,7 @@ params { } 'hg19' { fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/BismarkIndex/" @@ -298,7 +298,7 @@ params { } 'mm10' { fasta = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/BismarkIndex/" @@ -311,7 +311,7 @@ params { } 'bosTau8' { fasta = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/BismarkIndex/" @@ -321,7 +321,7 @@ params { } 'ce10' { fasta = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/BismarkIndex/" @@ -333,7 +333,7 @@ params { } 'canFam3' { fasta = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/BismarkIndex/" @@ -344,7 +344,7 @@ params { } 'danRer10' { fasta = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/BismarkIndex/" @@ -355,7 +355,7 @@ params { } 'dm6' { fasta = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/BismarkIndex/" @@ -366,7 +366,7 @@ params { } 'equCab2' { fasta = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/BismarkIndex/" @@ -377,7 +377,7 @@ params { } 'galGal4' { fasta = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/BismarkIndex/" @@ -388,7 +388,7 @@ params { } 'panTro4' { fasta = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/BismarkIndex/" @@ -399,7 +399,7 @@ params { } 'rn6' { fasta = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/BismarkIndex/" @@ -409,7 +409,7 @@ params { } 'sacCer3' { fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BismarkIndex/" @@ -419,7 +419,7 @@ params { } 'susScr3' { fasta = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/WholeGenomeFasta/genome.fa" - bwa = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BWAIndex/genome.fa" + bwa = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BWAIndex/version0.6.0/" bowtie2 = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/Bowtie2Index/" star = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/STARIndex/" bismark = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/BismarkIndex/" diff --git a/conf/modules.config b/conf/modules.config index a0506a4db..da58a5d88 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -1,12 +1,12 @@ /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Config file for defining DSL2 per module options and publishing paths -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Available keys to override module options: - ext.args = Additional arguments appended to command in module. - ext.args2 = Second set of arguments appended to command in module (multi-tool modules). - ext.args3 = Third set of arguments appended to command in module (multi-tool modules). - ext.prefix = File name prefix for output files. + ext.args = Additional arguments appended to command in module. + ext.args2 = Second set of arguments appended to command in module (multi-tool modules). + ext.args3 = Third set of arguments appended to command in module (multi-tool modules). + ext.prefix = File name prefix for output files. ---------------------------------------------------------------------------------------- */ @@ -14,14 +14,14 @@ process { publishDir = [ path: { "${params.outdir}/${task.process.tokenize(':')[-1].tokenize('_')[0].toLowerCase()}" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] withName: SAMPLESHEET_CHECK { publishDir = [ path: { "${params.outdir}/pipeline_info" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -33,7 +33,7 @@ process { withName: CUSTOM_DUMPSOFTWAREVERSIONS { publishDir = [ path: { "${params.outdir}/pipeline_info" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: '*_versions.yml' ] } diff --git a/conf/test.config b/conf/test.config index 3a199a627..2bf8a1faa 100644 --- a/conf/test.config +++ b/conf/test.config @@ -1,11 +1,11 @@ /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Nextflow config file for running minimal tests -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Defines input files and everything required to run a fast and simple pipeline test. Use as follows: - nextflow run nf-core/chipseq -profile test, + nextflow run nf-core/chipseq -profile test, --outdir ---------------------------------------------------------------------------------------- */ diff --git a/conf/test_full.config b/conf/test_full.config index d8fe4234c..5c3bc0808 100644 --- a/conf/test_full.config +++ b/conf/test_full.config @@ -1,11 +1,11 @@ /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Nextflow config file for running full-size tests -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Defines input files and everything required to run a full size pipeline test. Use as follows: - nextflow run nf-core/chipseq -profile test_full, + nextflow run nf-core/chipseq -profile test_full, --outdir ---------------------------------------------------------------------------------------- */ diff --git a/docs/images/nf-core-chipseq_logo_light.png b/docs/images/nf-core-chipseq_logo_light.png index d46347c2d217dd9a7c090367c55a068226f937c1..51a83b3d789d5852acc2bb044650b13785c6bf41 100644 GIT binary patch literal 73788 zcmeEt`9IX_`~RRQS?ZKSWhn*~p=96c5GGq9OZHNfecuPCQz(&w!1jG0qM))u18{N;szxKLnntC7*Z0~7*=;B1!jv^4p5Gb_^hQ29NgTYTSd@O|5 zS3HI44fR<@BwC_WweNAg^K`t?ay|Ua^`zuS;o*5X;p5j0nLR_3TdTw-*C$<<{Vk$; z9`%au>-b1%=CCl=x~!Jp!Br{RFpzjKp!3X+Tb;*QRKss@Kb){h^c+@seV?p-3zMBT zv9)Zlu({<`v3Pc z_~QTk@G~L)&kz6ShyTBGp!b^mFYH1%8g&}PE+NMRdy{Rgwkaa9QvrRQY2HJz)6`6H z9;J$!8p?T$p0J;N*Ye!J#ykH8M)iUCxVX5E!@pK|Rzc1t45Gxe-2E^GvsRWhY(8G+ zqQw!LH!;zIl^)J$8$X^IcCItbD!;xEnF(K*M&+X@JSfW~(%%?AjAD}I{FvT)!b;+< zT`3RVvHyDV#tr{F?pFSzX|tN{P8k1QHN6RI-9sVD@-lUEm%l0Eg`Uqb{CpIznVgoC 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J-waT~81OO72jb}RoLJM9sUyE8jGGwP=P zT({r52Hx8DE$sF$+szslcT#Se_EpNdtuM&KawTQ+v8aUV!(c1b6Y4w!6D(Cvt4H`E zKADbS@9>1i;=z)V7g#7c)78Q2R21&3KiPRN)L6AW!IagA!AuZn7(F8!n;^O(3&GEL z`IdZS!SoYp3ZUbR4QN~-hc4sVpItBmfoJG&#Lk2yM)p}|n3k}!gi}7^1bED6U@;Ic zl^ka$&sv*cyhCf#Eg<}pQxJ33KjQ@CIv?|QCJpD_6tkR+I~LC|e?kXMA=kc(1G!N4 VJvv>8IrcTl)qtG)%H@^D#V=*Sk$eCE diff --git a/docs/usage.md b/docs/usage.md index d1e7eebc7..0a8f0ebd0 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -57,7 +57,7 @@ An [example samplesheet](../assets/samplesheet.csv) has been provided with the p The typical command for running the pipeline is as follows: ```console -nextflow run nf-core/chipseq --input samplesheet.csv --genome GRCh37 -profile docker +nextflow run nf-core/chipseq --input samplesheet.csv --outdir --genome GRCh37 -profile docker ``` This will launch the pipeline with the `docker` configuration profile. See below for more information about profiles. @@ -141,11 +141,11 @@ Whilst the default requirements set within the pipeline will hopefully work for For example, if the nf-core/rnaseq pipeline is failing after multiple re-submissions of the `STAR_ALIGN` process due to an exit code of `137` this would indicate that there is an out of memory issue: ```console -[62/149eb0] NOTE: Process `RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)` terminated with an error exit status (137) -- Execution is retried (1) -Error executing process > 'RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)' +[62/149eb0] NOTE: Process `NFCORE_RNASEQ:RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)` terminated with an error exit status (137) -- Execution is retried (1) +Error executing process > 'NFCORE_RNASEQ:RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)' Caused by: - Process `RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)` terminated with an error exit status (137) + Process `NFCORE_RNASEQ:RNASEQ:ALIGN_STAR:STAR_ALIGN (WT_REP1)` terminated with an error exit status (137) Command executed: STAR \ @@ -169,17 +169,24 @@ Work dir: Tip: you can replicate the issue by changing to the process work dir and entering the command `bash .command.run` ``` -To bypass this error you would need to find exactly which resources are set by the `STAR_ALIGN` process. The quickest way is to search for `process STAR_ALIGN` in the [nf-core/rnaseq Github repo](https://github.com/nf-core/rnaseq/search?q=process+STAR_ALIGN). We have standardised the structure of Nextflow DSL2 pipelines such that all module files will be present in the `modules/` directory and so based on the search results the file we want is `modules/nf-core/software/star/align/main.nf`. If you click on the link to that file you will notice that there is a `label` directive at the top of the module that is set to [`label process_high`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/modules/nf-core/software/star/align/main.nf#L9). The [Nextflow `label`](https://www.nextflow.io/docs/latest/process.html#label) directive allows us to organise workflow processes in separate groups which can be referenced in a configuration file to select and configure subset of processes having similar computing requirements. The default values for the `process_high` label are set in the pipeline's [`base.config`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/base.config#L33-L37) which in this case is defined as 72GB. Providing you haven't set any other standard nf-core parameters to __cap__ the [maximum resources](https://nf-co.re/usage/configuration#max-resources) used by the pipeline then we can try and bypass the `STAR_ALIGN` process failure by creating a custom config file that sets at least 72GB of memory, in this case increased to 100GB. The custom config below can then be provided to the pipeline via the [`-c`](#-c) parameter as highlighted in previous sections. +To bypass this error you would need to find exactly which resources are set by the `STAR_ALIGN` process. The quickest way is to search for `process STAR_ALIGN` in the [nf-core/rnaseq Github repo](https://github.com/nf-core/rnaseq/search?q=process+STAR_ALIGN). +We have standardised the structure of Nextflow DSL2 pipelines such that all module files will be present in the `modules/` directory and so, based on the search results, the file we want is `modules/nf-core/software/star/align/main.nf`. +If you click on the link to that file you will notice that there is a `label` directive at the top of the module that is set to [`label process_high`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/modules/nf-core/software/star/align/main.nf#L9). +The [Nextflow `label`](https://www.nextflow.io/docs/latest/process.html#label) directive allows us to organise workflow processes in separate groups which can be referenced in a configuration file to select and configure subset of processes having similar computing requirements. +The default values for the `process_high` label are set in the pipeline's [`base.config`](https://github.com/nf-core/rnaseq/blob/4c27ef5610c87db00c3c5a3eed10b1d161abf575/conf/base.config#L33-L37) which in this case is defined as 72GB. +Providing you haven't set any other standard nf-core parameters to **cap** the [maximum resources](https://nf-co.re/usage/configuration#max-resources) used by the pipeline then we can try and bypass the `STAR_ALIGN` process failure by creating a custom config file that sets at least 72GB of memory, in this case increased to 100GB. +The custom config below can then be provided to the pipeline via the [`-c`](#-c) parameter as highlighted in previous sections. ```nextflow process { - withName: STAR_ALIGN { + withName: 'NFCORE_RNASEQ:RNASEQ:ALIGN_STAR:STAR_ALIGN' { memory = 100.GB } } ``` -> **NB:** We specify just the process name i.e. `STAR_ALIGN` in the config file and not the full task name string that is printed to screen in the error message or on the terminal whilst the pipeline is running i.e. `RNASEQ:ALIGN_STAR:STAR_ALIGN`. You may get a warning suggesting that the process selector isn't recognised but you can ignore that if the process name has been specified correctly. This is something that needs to be fixed upstream in core Nextflow. +> **NB:** We specify the full process name i.e. `NFCORE_RNASEQ:RNASEQ:ALIGN_STAR:STAR_ALIGN` in the config file because this takes priority over the short name (`STAR_ALIGN`) and allows existing configuration using the full process name to be correctly overridden. +> If you get a warning suggesting that the process selector isn't recognised check that the process name has been specified correctly. ### Updating containers diff --git a/lib/NfcoreSchema.groovy b/lib/NfcoreSchema.groovy index 40ab65f20..b3d092f80 100755 --- a/lib/NfcoreSchema.groovy +++ b/lib/NfcoreSchema.groovy @@ -27,7 +27,7 @@ class NfcoreSchema { /* groovylint-disable-next-line UnusedPrivateMethodParameter */ public static void validateParameters(workflow, params, log, schema_filename='nextflow_schema.json') { def has_error = false - //=====================================================================// + //~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~// // Check for nextflow core params and unexpected params def json = new File(getSchemaPath(workflow, schema_filename=schema_filename)).text def Map schemaParams = (Map) new JsonSlurper().parseText(json).get('definitions') @@ -135,7 +135,7 @@ class NfcoreSchema { } } - //=====================================================================// + //~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~// // Validate parameters against the schema InputStream input_stream = new File(getSchemaPath(workflow, schema_filename=schema_filename)).newInputStream() JSONObject raw_schema = new JSONObject(new JSONTokener(input_stream)) diff --git a/lib/Utils.groovy b/lib/Utils.groovy index 1b88aec0e..28567bd70 100755 --- a/lib/Utils.groovy +++ b/lib/Utils.groovy @@ -29,12 +29,12 @@ class Utils { conda_check_failed |= !(channels.indexOf('bioconda') < channels.indexOf('defaults')) if (conda_check_failed) { - log.warn "=============================================================================\n" + + log.warn "~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~\n" + " There is a problem with your Conda configuration!\n\n" + " You will need to set-up the conda-forge and bioconda channels correctly.\n" + " Please refer to https://bioconda.github.io/user/install.html#set-up-channels\n" + " NB: The order of the channels matters!\n" + - "===================================================================================" + "~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~" } } } diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index 4ca6323ae..547194f75 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -48,11 +48,11 @@ class WorkflowChipseq { // private static void genomeExistsError(params, log) { if (params.genomes && params.genome && !params.genomes.containsKey(params.genome)) { - log.error "=============================================================================\n" + + log.error "~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~\n" + " Genome '${params.genome}' not found in any config files provided to the pipeline.\n" + " Currently, the available genome keys are:\n" + " ${params.genomes.keySet().join(", ")}\n" + - "===================================================================================" + "~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~" System.exit(1) } } diff --git a/main.nf b/main.nf index 7a90164a5..cf50b1183 100644 --- a/main.nf +++ b/main.nf @@ -1,8 +1,8 @@ #!/usr/bin/env nextflow /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ nf-core/chipseq -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Github : https://github.com/nf-core/chipseq Website: https://nf-co.re/chipseq Slack : https://nfcore.slack.com/channels/chipseq @@ -12,25 +12,25 @@ nextflow.enable.dsl = 2 /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ GENOME PARAMETER VALUES -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ params.fasta = WorkflowMain.getGenomeAttribute(params, 'fasta') /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ VALIDATE & PRINT PARAMETER SUMMARY -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ WorkflowMain.initialise(workflow, params, log) /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ NAMED WORKFLOW FOR PIPELINE -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ include { CHIPSEQ } from './workflows/chipseq' @@ -43,9 +43,9 @@ workflow NFCORE_CHIPSEQ { } /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ RUN ALL WORKFLOWS -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ // @@ -57,7 +57,7 @@ workflow { } /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ THE END -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ diff --git a/nextflow.config b/nextflow.config index e5ae4e45b..d7b8696c4 100644 --- a/nextflow.config +++ b/nextflow.config @@ -1,7 +1,7 @@ /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ nf-core/chipseq Nextflow config file -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Default config options for all compute environments ---------------------------------------------------------------------------------------- */ @@ -24,8 +24,9 @@ params { max_multiqc_email_size = '25.MB' // Boilerplate options - outdir = './results' + outdir = null tracedir = "${params.outdir}/pipeline_info" + publish_dir_mode = 'copy' email = null email_on_fail = null plaintext_email = false @@ -62,6 +63,15 @@ try { System.err.println("WARNING: Could not load nf-core/config profiles: ${params.custom_config_base}/nfcore_custom.config") } +// Load nf-core/chipseq custom profiles from different institutions. +// Warning: Uncomment only if a pipeline-specific instititutional config already exists on nf-core/configs! +// try { +// includeConfig "${params.custom_config_base}/pipeline/chipseq.config" +// } catch (Exception e) { +// System.err.println("WARNING: Could not load nf-core/config/chipseq profiles: ${params.custom_config_base}/pipeline/chipseq.config") +// } + + profiles { debug { process.beforeScript = 'echo $HOSTNAME' } conda { @@ -121,7 +131,7 @@ if (!params.igenomes_ignore) { } // Export these variables to prevent local Python/R libraries from conflicting with those in the container -// The JULIA depot path has been adjusted to a fixed path `/usr/local/share/julia` that needs to be used for packages in the container. +// The JULIA depot path has been adjusted to a fixed path `/usr/local/share/julia` that needs to be used for packages in the container. // See https://apeltzer.github.io/post/03-julia-lang-nextflow/ for details on that. Once we have a common agreement on where to keep Julia packages, this is adjustable. env { @@ -154,7 +164,7 @@ dag { manifest { name = 'nf-core/chipseq' - author = 'Philip Ewels' + author = 'Philip Ewels, Jose Espinosa-Carrasco, Harshil Patel' homePage = 'https://github.com/nf-core/chipseq' description = 'ChIP-seq peak-calling and differential analysis pipeline.' mainScript = 'main.nf' diff --git a/nextflow_schema.json b/nextflow_schema.json index 91a37921a..0ae1bfc8f 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -11,7 +11,8 @@ "fa_icon": "fas fa-terminal", "description": "Define where the pipeline should find input data and save output data.", "required": [ - "input" + "input", + "outdir" ], "properties": { "input": { @@ -26,8 +27,8 @@ }, "outdir": { "type": "string", - "description": "Path to the output directory where the results will be saved.", - "default": "./results", + "format": "directory-path", + "description": "The output directory where the results will be saved. You have to use absolute paths to storage on Cloud infrastructure.", "fa_icon": "fas fa-folder-open" }, "email": { @@ -178,6 +179,22 @@ "fa_icon": "fas fa-question-circle", "hidden": true }, + "publish_dir_mode": { + "type": "string", + "default": "copy", + "description": "Method used to save pipeline results to output directory.", + "help_text": "The Nextflow `publishDir` option specifies which intermediate files should be saved to the output directory. This option tells the pipeline what method should be used to move these files. See [Nextflow docs](https://www.nextflow.io/docs/latest/process.html#publishdir) for details.", + "fa_icon": "fas fa-copy", + "enum": [ + "symlink", + "rellink", + "link", + "copy", + "copyNoFollow", + "move" + ], + "hidden": true + }, "email_on_fail": { "type": "string", "description": "Email address for completion summary, only when pipeline fails.", diff --git a/subworkflows/local/input_check.nf b/subworkflows/local/input_check.nf index cddcbb3ce..0aecf87fb 100644 --- a/subworkflows/local/input_check.nf +++ b/subworkflows/local/input_check.nf @@ -12,7 +12,7 @@ workflow INPUT_CHECK { SAMPLESHEET_CHECK ( samplesheet ) .csv .splitCsv ( header:true, sep:',' ) - .map { create_fastq_channels(it) } + .map { create_fastq_channel(it) } .set { reads } emit: @@ -21,22 +21,24 @@ workflow INPUT_CHECK { } // Function to get list of [ meta, [ fastq_1, fastq_2 ] ] -def create_fastq_channels(LinkedHashMap row) { +def create_fastq_channel(LinkedHashMap row) { + // create meta map def meta = [:] - meta.id = row.sample - meta.single_end = row.single_end.toBoolean() + meta.id = row.sample + meta.single_end = row.single_end.toBoolean() - def array = [] + // add path(s) of the fastq file(s) to the meta map + def fastq_meta = [] if (!file(row.fastq_1).exists()) { exit 1, "ERROR: Please check input samplesheet -> Read 1 FastQ file does not exist!\n${row.fastq_1}" } if (meta.single_end) { - array = [ meta, [ file(row.fastq_1) ] ] + fastq_meta = [ meta, [ file(row.fastq_1) ] ] } else { if (!file(row.fastq_2).exists()) { exit 1, "ERROR: Please check input samplesheet -> Read 2 FastQ file does not exist!\n${row.fastq_2}" } - array = [ meta, [ file(row.fastq_1), file(row.fastq_2) ] ] + fastq_meta = [ meta, [ file(row.fastq_1), file(row.fastq_2) ] ] } - return array + return fastq_meta } diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 5714aa820..0a51968e9 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -1,7 +1,7 @@ /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ VALIDATE INPUTS -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ def summary_params = NfcoreSchema.paramsSummaryMap(workflow, params) @@ -18,18 +18,18 @@ for (param in checkPathParamList) { if (param) { file(param, checkIfExists: true if (params.input) { ch_input = file(params.input) } else { exit 1, 'Input samplesheet not specified!' } /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ CONFIG FILES -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ ch_multiqc_config = file("$projectDir/assets/multiqc_config.yaml", checkIfExists: true) ch_multiqc_custom_config = params.multiqc_config ? Channel.fromPath(params.multiqc_config) : Channel.empty() /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ IMPORT LOCAL MODULES/SUBWORKFLOWS -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ // @@ -38,9 +38,9 @@ ch_multiqc_custom_config = params.multiqc_config ? Channel.fromPath(params.multi include { INPUT_CHECK } from '../subworkflows/local/input_check' /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ IMPORT NF-CORE MODULES/SUBWORKFLOWS -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ // @@ -51,9 +51,9 @@ include { MULTIQC } from '../modules/nf-core/modules/multiqc include { CUSTOM_DUMPSOFTWAREVERSIONS } from '../modules/nf-core/modules/custom/dumpsoftwareversions/main' /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ RUN MAIN WORKFLOW -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ // Info required for completion email and summary @@ -104,9 +104,9 @@ workflow CHIPSEQ { } /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ COMPLETION EMAIL AND SUMMARY -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ workflow.onComplete { @@ -117,7 +117,7 @@ workflow.onComplete { } /* -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ THE END -======================================================================================== +~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ From b0216955bd14f5f19d2c1b26ff08c00e3db781af Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 22 Mar 2022 19:17:43 +0100 Subject: [PATCH 350/538] Update changelog --- CHANGELOG.md | 1 + 1 file changed, 1 insertion(+) diff --git a/CHANGELOG.md b/CHANGELOG.md index 6573b686e..de456d084 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -7,6 +7,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 ### Enhancements & fixes +* Update pipeline template to nf-core/tools `2.2` * Port pipeline to the updated Nextflow DSL2 syntax adopted on nf-core/modules * Removed `--publish_dir_mode` as it is no longer required for the new syntax * Bump minimum Nextflow version from `21.04.0` -> `21.10.3` From 0f2accbe5ccde1d8b5d01dba243f94e0020de26e Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 22 Mar 2022 23:08:46 +0100 Subject: [PATCH 351/538] Fix lint and get rid of some merge tags that were remaining --- README.md | 7 ------- docs/usage.md | 4 ---- subworkflows/local/input_check.nf | 4 ---- 3 files changed, 15 deletions(-) diff --git a/README.md b/README.md index 7ffc9890e..fc1bf270d 100644 --- a/README.md +++ b/README.md @@ -75,19 +75,12 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool 4. Start running your own analysis! -<<<<<<< HEAD ```bash nextflow run nf-core/chipseq \ --input samplesheet.csv \ --outdir \ --genome GRCh37 \ -profile -======= - - - ```console - nextflow run nf-core/chipseq --input samplesheet.csv --outdir --genome GRCh37 -profile ->>>>>>> 10573c6d2c8c280bc6de4e6c19cb41d64a98a322 ``` See [usage docs](https://nf-co.re/chipseq/usage) for all of the available options when running the pipeline. diff --git a/docs/usage.md b/docs/usage.md index 5e9e5d4f0..425066f35 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -117,11 +117,7 @@ wget -L https://www.encodeproject.org/files/ENCFF356LFX/@@download/ENCFF356LFX.b The typical command for running the pipeline is as follows: ```console -<<<<<<< HEAD nextflow run nf-core/chipseq --input samplesheet.csv --outdir --genome GRCh37 -profile docker -======= -nextflow run nf-core/chipseq --input samplesheet.csv --outdir --genome GRCh37 -profile docker ->>>>>>> 10573c6d2c8c280bc6de4e6c19cb41d64a98a322 ``` This will launch the pipeline with the `docker` configuration profile. See below for more information about profiles. diff --git a/subworkflows/local/input_check.nf b/subworkflows/local/input_check.nf index 2b558660e..648a2971a 100644 --- a/subworkflows/local/input_check.nf +++ b/subworkflows/local/input_check.nf @@ -13,11 +13,7 @@ workflow INPUT_CHECK { SAMPLESHEET_CHECK ( samplesheet ) .csv .splitCsv ( header:true, sep:',' ) -<<<<<<< HEAD .map { create_fastq_channel(it, seq_center) } -======= - .map { create_fastq_channel(it) } ->>>>>>> 10573c6d2c8c280bc6de4e6c19cb41d64a98a322 .set { reads } emit: From 441e9170a32b365d9c6e51f686a916b60320beb8 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 22 Mar 2022 23:15:29 +0100 Subject: [PATCH 352/538] Fix yamllint --- .nf-core.yml | 1 - 1 file changed, 1 deletion(-) diff --git a/.nf-core.yml b/.nf-core.yml index f6d7f980b..1249eb378 100644 --- a/.nf-core.yml +++ b/.nf-core.yml @@ -12,4 +12,3 @@ lint: - .github/workflows/linting_comment.yml - .github/workflows/linting.yml - bin/check_samplesheet.py - From dc3a8c04c2da9648da026a66618c1e1cc1ad68df Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Wed, 23 Mar 2022 13:47:24 +0000 Subject: [PATCH 353/538] Template update for nf-core/tools version 2.3.1 --- .editorconfig | 5 +- .github/CONTRIBUTING.md | 15 +- .github/ISSUE_TEMPLATE/bug_report.yml | 1 - .github/PULL_REQUEST_TEMPLATE.md | 6 +- .github/workflows/awsfulltest.yml | 1 - .github/workflows/awstest.yml | 2 +- .github/workflows/branch.yml | 5 +- .github/workflows/ci.yml | 12 +- .github/workflows/linting.yml | 85 ++--------- .github/workflows/linting_comment.yml | 3 +- .gitpod.yml | 16 +- .markdownlint.yml | 14 -- .prettierrc.yml | 1 + .yamllint.yml | 6 - CHANGELOG.md | 2 + CITATIONS.md | 27 ++-- README.md | 31 ++-- assets/email_template.html | 142 ++++++++++++------ assets/multiqc_config.yaml | 11 -- assets/multiqc_config.yml | 11 ++ assets/schema_input.json | 5 +- docs/README.md | 8 +- docs/output.md | 28 ++-- docs/usage.md | 109 +++++++------- modules.json | 8 +- .../custom/dumpsoftwareversions/main.nf | 3 + .../custom/dumpsoftwareversions/meta.yml | 2 +- modules/nf-core/modules/fastqc/main.nf | 3 + modules/nf-core/modules/fastqc/meta.yml | 90 +++++------ modules/nf-core/modules/multiqc/main.nf | 9 +- modules/nf-core/modules/multiqc/meta.yml | 66 ++++---- nextflow_schema.json | 14 +- workflows/chipseq.nf | 2 +- 33 files changed, 361 insertions(+), 382 deletions(-) delete mode 100644 .markdownlint.yml create mode 100644 .prettierrc.yml delete mode 100644 .yamllint.yml delete mode 100644 assets/multiqc_config.yaml create mode 100644 assets/multiqc_config.yml diff --git a/.editorconfig b/.editorconfig index 95549501a..b6b319077 100644 --- a/.editorconfig +++ b/.editorconfig @@ -8,12 +8,9 @@ trim_trailing_whitespace = true indent_size = 4 indent_style = space -[*.{yml,yaml}] +[*.{md,yml,yaml,html,css,scss,js}] indent_size = 2 -[*.json] -insert_final_newline = unset - # These files are edited and tested upstream in nf-core/modules [/modules/nf-core/**] charset = unset diff --git a/.github/CONTRIBUTING.md b/.github/CONTRIBUTING.md index d37fb5dfa..2bfaa6814 100644 --- a/.github/CONTRIBUTING.md +++ b/.github/CONTRIBUTING.md @@ -15,8 +15,7 @@ Contributions to the code are even more welcome ;) If you'd like to write some code for nf-core/chipseq, the standard workflow is as follows: -1. Check that there isn't already an issue about your idea in the [nf-core/chipseq issues](https://github.com/nf-core/chipseq/issues) to avoid duplicating work - * If there isn't one already, please create one so that others know you're working on this +1. Check that there isn't already an issue about your idea in the [nf-core/chipseq issues](https://github.com/nf-core/chipseq/issues) to avoid duplicating work. If there isn't one already, please create one so that others know you're working on this 2. [Fork](https://help.github.com/en/github/getting-started-with-github/fork-a-repo) the [nf-core/chipseq repository](https://github.com/nf-core/chipseq) to your GitHub account 3. Make the necessary changes / additions within your forked repository following [Pipeline conventions](#pipeline-contribution-conventions) 4. Use `nf-core schema build` and add any new parameters to the pipeline JSON schema (requires [nf-core tools](https://github.com/nf-core/tools) >= 1.10). @@ -49,9 +48,9 @@ These tests are run both with the latest available version of `Nextflow` and als :warning: Only in the unlikely and regretful event of a release happening with a bug. -* On your own fork, make a new branch `patch` based on `upstream/master`. -* Fix the bug, and bump version (X.Y.Z+1). -* A PR should be made on `master` from patch to directly this particular bug. +- On your own fork, make a new branch `patch` based on `upstream/master`. +- Fix the bug, and bump version (X.Y.Z+1). +- A PR should be made on `master` from patch to directly this particular bug. ## Getting help @@ -73,7 +72,7 @@ If you wish to contribute a new step, please use the following coding standards: 6. Add sanity checks and validation for all relevant parameters. 7. Perform local tests to validate that the new code works as expected. 8. If applicable, add a new test command in `.github/workflow/ci.yml`. -9. Update MultiQC config `assets/multiqc_config.yaml` so relevant suffixes, file name clean up and module plots are in the appropriate order. If applicable, add a [MultiQC](https://https://multiqc.info/) module. +9. Update MultiQC config `assets/multiqc_config.yml` so relevant suffixes, file name clean up and module plots are in the appropriate order. If applicable, add a [MultiQC](https://https://multiqc.info/) module. 10. Add a description of the output files and if relevant any appropriate images from the MultiQC report to `docs/output.md`. ### Default values @@ -92,8 +91,8 @@ The process resources can be passed on to the tool dynamically within the proces Please use the following naming schemes, to make it easy to understand what is going where. -* initial process channel: `ch_output_from_` -* intermediate and terminal channels: `ch__for_` +- initial process channel: `ch_output_from_` +- intermediate and terminal channels: `ch__for_` ### Nextflow version bumping diff --git a/.github/ISSUE_TEMPLATE/bug_report.yml b/.github/ISSUE_TEMPLATE/bug_report.yml index ecfb25027..1d09e717d 100644 --- a/.github/ISSUE_TEMPLATE/bug_report.yml +++ b/.github/ISSUE_TEMPLATE/bug_report.yml @@ -2,7 +2,6 @@ name: Bug report description: Report something that is broken or incorrect labels: bug body: - - type: markdown attributes: value: | diff --git a/.github/PULL_REQUEST_TEMPLATE.md b/.github/PULL_REQUEST_TEMPLATE.md index 88c55b84f..a847bce64 100644 --- a/.github/PULL_REQUEST_TEMPLATE.md +++ b/.github/PULL_REQUEST_TEMPLATE.md @@ -16,10 +16,10 @@ Learn more about contributing: [CONTRIBUTING.md](https://github.com/nf-core/chip - [ ] This comment contains a description of changes (with reason). - [ ] If you've fixed a bug or added code that should be tested, add tests! - - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) - - [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. + - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) + - [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. - [ ] Make sure your code lints (`nf-core lint`). -- [ ] Ensure the test suite passes (`nextflow run . -profile test,docker` --outdir `). +- [ ] Ensure the test suite passes (`nextflow run . -profile test,docker --outdir `). - [ ] Usage Documentation in `docs/usage.md` is updated. - [ ] Output Documentation in `docs/output.md` is updated. - [ ] `CHANGELOG.md` is updated. diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index c0851d163..32c4519c5 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -18,7 +18,6 @@ jobs: # TODO nf-core: You can customise AWS full pipeline tests as required # Add full size test data (but still relatively small datasets for few samples) # on the `test_full.config` test runs with only one set of parameters - with: workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }} access_token: ${{ secrets.TOWER_ACCESS_TOKEN }} diff --git a/.github/workflows/awstest.yml b/.github/workflows/awstest.yml index 02bd219ef..e63a3be6b 100644 --- a/.github/workflows/awstest.yml +++ b/.github/workflows/awstest.yml @@ -10,9 +10,9 @@ jobs: if: github.repository == 'nf-core/chipseq' runs-on: ubuntu-latest steps: + # Launch workflow using Tower CLI tool action - name: Launch workflow via tower uses: nf-core/tower-action@v3 - with: workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }} access_token: ${{ secrets.TOWER_ACCESS_TOKEN }} diff --git a/.github/workflows/branch.yml b/.github/workflows/branch.yml index 0615f2af9..5a5468e14 100644 --- a/.github/workflows/branch.yml +++ b/.github/workflows/branch.yml @@ -13,8 +13,7 @@ jobs: - name: Check PRs if: github.repository == 'nf-core/chipseq' run: | - { [[ ${{github.event.pull_request.head.repo.full_name }} == nf-core/chipseq ]] && [[ $GITHUB_HEAD_REF = "dev" ]]; } || [[ $GITHUB_HEAD_REF == "patch" ]] - + "{ [[ ${{github.event.pull_request.head.repo.full_name }} == nf-core/chipseq ]] && [[ $GITHUB_HEAD_REF = "dev" ]]; } || [[ $GITHUB_HEAD_REF == "patch" ]]" # If the above check failed, post a comment on the PR explaining the failure # NOTE - this doesn't currently work if the PR is coming from a fork, due to limitations in GitHub actions secrets @@ -43,4 +42,4 @@ jobs: Thanks again for your contribution! repo-token: ${{ secrets.GITHUB_TOKEN }} allow-repeats: false - +# diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index d8f2c0e5f..b78f34dff 100644 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -16,18 +16,18 @@ jobs: test: name: Run pipeline with test data # Only run on push if this is the nf-core dev branch (merged PRs) - if: ${{ github.event_name != 'push' || (github.event_name == 'push' && github.repository == 'nf-core/chipseq') }} + if: "${{ github.event_name != 'push' || (github.event_name == 'push' && github.repository == 'nf-core/chipseq') }}" runs-on: ubuntu-latest strategy: matrix: # Nextflow versions include: # Test pipeline minimum Nextflow version - - NXF_VER: '21.10.3' - NXF_EDGE: '' + - NXF_VER: "21.10.3" + NXF_EDGE: "" # Test latest edge release of Nextflow - - NXF_VER: '' - NXF_EDGE: '1' + - NXF_VER: "" + NXF_EDGE: "1" steps: - name: Check out pipeline code uses: actions/checkout@v2 @@ -48,3 +48,5 @@ jobs: # Remember that you can parallelise this by using strategy.matrix run: | nextflow run ${GITHUB_WORKSPACE} -profile test,docker --outdir ./results + +# diff --git a/.github/workflows/linting.yml b/.github/workflows/linting.yml index fda934c03..e9cf5de3a 100644 --- a/.github/workflows/linting.yml +++ b/.github/workflows/linting.yml @@ -1,6 +1,7 @@ name: nf-core linting # This workflow is triggered on pushes and PRs to the repository. -# It runs the `nf-core lint` and markdown lint tests to ensure that the code meets the nf-core guidelines +# It runs the `nf-core lint` and markdown lint tests to ensure +# that the code meets the nf-core guidelines. on: push: pull_request: @@ -8,42 +9,6 @@ on: types: [published] jobs: - Markdown: - runs-on: ubuntu-latest - steps: - - uses: actions/checkout@v2 - - uses: actions/setup-node@v2 - - name: Install markdownlint - run: npm install -g markdownlint-cli - - name: Run Markdownlint - run: markdownlint . - - # If the above check failed, post a comment on the PR explaining the failure - - name: Post PR comment - if: failure() - uses: mshick/add-pr-comment@v1 - with: - message: | - ## Markdown linting is failing - - To keep the code consistent with lots of contributors, we run automated code consistency checks. - To fix this CI test, please run: - - * Install `markdownlint-cli` - * On Mac: `brew install markdownlint-cli` - * Everything else: [Install `npm`](https://www.npmjs.com/get-npm) then [install `markdownlint-cli`](https://www.npmjs.com/package/markdownlint-cli) (`npm install -g markdownlint-cli`) - * Fix the markdown errors - * Automatically: `markdownlint . --fix` - * Manually resolve anything left from `markdownlint .` - - Once you push these changes the test should pass, and you can hide this comment :+1: - - We highly recommend setting up markdownlint in your code editor so that this formatting is done automatically on save. Ask about it on Slack for help! - - Thanks again for your contribution! - repo-token: ${{ secrets.GITHUB_TOKEN }} - allow-repeats: false - EditorConfig: runs-on: ubuntu-latest steps: @@ -55,49 +20,24 @@ jobs: run: npm install -g editorconfig-checker - name: Run ECLint check - run: editorconfig-checker -exclude README.md $(git ls-files | grep -v test) + run: editorconfig-checker -exclude README.md $(find .* -type f | grep -v '.git\|.py\|.md\|json\|yml\|yaml\|html\|css\|work\|.nextflow\|build\|nf_core.egg-info\|log.txt\|Makefile') - YAML: + Prettier: runs-on: ubuntu-latest steps: - - name: Checkout - uses: actions/checkout@master - - name: 'Yamllint' - uses: karancode/yamllint-github-action@master - with: - yamllint_file_or_dir: '.' - yamllint_config_filepath: '.yamllint.yml' - - # If the above check failed, post a comment on the PR explaining the failure - - name: Post PR comment - if: failure() - uses: mshick/add-pr-comment@v1 - with: - message: | - ## YAML linting is failing - - To keep the code consistent with lots of contributors, we run automated code consistency checks. - To fix this CI test, please run: - - * Install `yamllint` - * Install `yamllint` following [this](https://yamllint.readthedocs.io/en/stable/quickstart.html#installing-yamllint) - instructions or alternative install it in your [conda environment](https://anaconda.org/conda-forge/yamllint) - * Fix the markdown errors - * Run the test locally: `yamllint $(find . -type f -name "*.yml" -o -name "*.yaml") -c ./.yamllint.yml` - * Fix any reported errors in your YAML files + - uses: actions/checkout@v2 - Once you push these changes the test should pass, and you can hide this comment :+1: + - uses: actions/setup-node@v2 - We highly recommend setting up yaml-lint in your code editor so that this formatting is done automatically on save. Ask about it on Slack for help! + - name: Install Prettier + run: npm install -g prettier - Thanks again for your contribution! - repo-token: ${{ secrets.GITHUB_TOKEN }} - allow-repeats: false + - name: Run Prettier --check + run: prettier --check ${GITHUB_WORKSPACE} nf-core: runs-on: ubuntu-latest steps: - - name: Check out pipeline code uses: actions/checkout@v2 @@ -110,8 +50,8 @@ jobs: - uses: actions/setup-python@v1 with: - python-version: '3.6' - architecture: 'x64' + python-version: "3.6" + architecture: "x64" - name: Install dependencies run: | @@ -139,3 +79,4 @@ jobs: lint_results.md PR_number.txt +# diff --git a/.github/workflows/linting_comment.yml b/.github/workflows/linting_comment.yml index 44d72994b..91c487a1a 100644 --- a/.github/workflows/linting_comment.yml +++ b/.github/workflows/linting_comment.yml @@ -1,4 +1,3 @@ - name: nf-core linting comment # This workflow is triggered after the linting action is complete # It posts an automated comment to the PR, even if the PR is coming from a fork @@ -27,4 +26,4 @@ jobs: GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }} number: ${{ steps.pr_number.outputs.pr_number }} path: linting-logs/lint_results.md - +# diff --git a/.gitpod.yml b/.gitpod.yml index b7d4cee18..c452ee93e 100644 --- a/.gitpod.yml +++ b/.gitpod.yml @@ -2,13 +2,13 @@ image: nfcore/gitpod:latest vscode: extensions: # based on nf-core.nf-core-extensionpack - - codezombiech.gitignore # Language support for .gitignore files + - codezombiech.gitignore # Language support for .gitignore files # - cssho.vscode-svgviewer # SVG viewer - - davidanson.vscode-markdownlint # Markdown/CommonMark linting and style checking for Visual Studio Code - - eamodio.gitlens # Quickly glimpse into whom, why, and when a line or code block was changed - - EditorConfig.EditorConfig # override user/workspace settings with settings found in .editorconfig files - - Gruntfuggly.todo-tree # Display TODO and FIXME in a tree view in the activity bar - - mechatroner.rainbow-csv # Highlight columns in csv files in different colors + - davidanson.vscode-markdownlint # Markdown/CommonMark linting and style checking for Visual Studio Code + - eamodio.gitlens # Quickly glimpse into whom, why, and when a line or code block was changed + - EditorConfig.EditorConfig # override user/workspace settings with settings found in .editorconfig files + - Gruntfuggly.todo-tree # Display TODO and FIXME in a tree view in the activity bar + - mechatroner.rainbow-csv # Highlight columns in csv files in different colors # - nextflow.nextflow # Nextflow syntax highlighting - - oderwat.indent-rainbow # Highlight indentation level - - streetsidesoftware.code-spell-checker # Spelling checker for source code + - oderwat.indent-rainbow # Highlight indentation level + - streetsidesoftware.code-spell-checker # Spelling checker for source code diff --git a/.markdownlint.yml b/.markdownlint.yml deleted file mode 100644 index 9e605fcfa..000000000 --- a/.markdownlint.yml +++ /dev/null @@ -1,14 +0,0 @@ -# Markdownlint configuration file -default: true -line-length: false -ul-indent: - indent: 4 -no-duplicate-header: - siblings_only: true -no-inline-html: - allowed_elements: - - img - - p - - kbd - - details - - summary diff --git a/.prettierrc.yml b/.prettierrc.yml new file mode 100644 index 000000000..c81f9a766 --- /dev/null +++ b/.prettierrc.yml @@ -0,0 +1 @@ +printWidth: 120 diff --git a/.yamllint.yml b/.yamllint.yml deleted file mode 100644 index d466deec9..000000000 --- a/.yamllint.yml +++ /dev/null @@ -1,6 +0,0 @@ -extends: default - -rules: - document-start: disable - line-length: disable - truthy: disable diff --git a/CHANGELOG.md b/CHANGELOG.md index bcbe42c1b..b21fe9d0c 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -11,6 +11,8 @@ Initial release of nf-core/chipseq, created with the [nf-core](https://nf-co.re/ ### `Fixed` +- Clarified conda usage and added an installation tutorial for Singularity since the one on Syllabs' website uses an outdate version of GO Compiler + ### `Dependencies` ### `Deprecated` diff --git a/CITATIONS.md b/CITATIONS.md index cecb5945f..b4b3c8965 100644 --- a/CITATIONS.md +++ b/CITATIONS.md @@ -10,23 +10,26 @@ ## Pipeline tools -* [FastQC](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/) +- [FastQC](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/) -* [MultiQC](https://pubmed.ncbi.nlm.nih.gov/27312411/) - > Ewels P, Magnusson M, Lundin S, Käller M. MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics. 2016 Oct 1;32(19):3047-8. doi: 10.1093/bioinformatics/btw354. Epub 2016 Jun 16. PubMed PMID: 27312411; PubMed Central PMCID: PMC5039924. +- [MultiQC](https://pubmed.ncbi.nlm.nih.gov/27312411/) + > Ewels P, Magnusson M, Lundin S, Käller M. MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics. 2016 Oct 1;32(19):3047-8. doi: 10.1093/bioinformatics/btw354. Epub 2016 Jun 16. PubMed PMID: 27312411; PubMed Central PMCID: PMC5039924. ## Software packaging/containerisation tools -* [Anaconda](https://anaconda.com) - > Anaconda Software Distribution. Computer software. Vers. 2-2.4.0. Anaconda, Nov. 2016. Web. +- [Anaconda](https://anaconda.com) -* [Bioconda](https://pubmed.ncbi.nlm.nih.gov/29967506/) - > Grüning B, Dale R, Sjödin A, Chapman BA, Rowe J, Tomkins-Tinch CH, Valieris R, Köster J; Bioconda Team. Bioconda: sustainable and comprehensive software distribution for the life sciences. Nat Methods. 2018 Jul;15(7):475-476. doi: 10.1038/s41592-018-0046-7. PubMed PMID: 29967506. + > Anaconda Software Distribution. Computer software. Vers. 2-2.4.0. Anaconda, Nov. 2016. Web. -* [BioContainers](https://pubmed.ncbi.nlm.nih.gov/28379341/) - > da Veiga Leprevost F, Grüning B, Aflitos SA, Röst HL, Uszkoreit J, Barsnes H, Vaudel M, Moreno P, Gatto L, Weber J, Bai M, Jimenez RC, Sachsenberg T, Pfeuffer J, Alvarez RV, Griss J, Nesvizhskii AI, Perez-Riverol Y. BioContainers: an open-source and community-driven framework for software standardization. Bioinformatics. 2017 Aug 15;33(16):2580-2582. doi: 10.1093/bioinformatics/btx192. PubMed PMID: 28379341; PubMed Central PMCID: PMC5870671. +- [Bioconda](https://pubmed.ncbi.nlm.nih.gov/29967506/) -* [Docker](https://dl.acm.org/doi/10.5555/2600239.2600241) + > Grüning B, Dale R, Sjödin A, Chapman BA, Rowe J, Tomkins-Tinch CH, Valieris R, Köster J; Bioconda Team. Bioconda: sustainable and comprehensive software distribution for the life sciences. Nat Methods. 2018 Jul;15(7):475-476. doi: 10.1038/s41592-018-0046-7. PubMed PMID: 29967506. -* [Singularity](https://pubmed.ncbi.nlm.nih.gov/28494014/) - > Kurtzer GM, Sochat V, Bauer MW. Singularity: Scientific containers for mobility of compute. PLoS One. 2017 May 11;12(5):e0177459. doi: 10.1371/journal.pone.0177459. eCollection 2017. PubMed PMID: 28494014; PubMed Central PMCID: PMC5426675. +- [BioContainers](https://pubmed.ncbi.nlm.nih.gov/28379341/) + + > da Veiga Leprevost F, Grüning B, Aflitos SA, Röst HL, Uszkoreit J, Barsnes H, Vaudel M, Moreno P, Gatto L, Weber J, Bai M, Jimenez RC, Sachsenberg T, Pfeuffer J, Alvarez RV, Griss J, Nesvizhskii AI, Perez-Riverol Y. BioContainers: an open-source and community-driven framework for software standardization. Bioinformatics. 2017 Aug 15;33(16):2580-2582. doi: 10.1093/bioinformatics/btx192. PubMed PMID: 28379341; PubMed Central PMCID: PMC5870671. + +- [Docker](https://dl.acm.org/doi/10.5555/2600239.2600241) + +- [Singularity](https://pubmed.ncbi.nlm.nih.gov/28494014/) + > Kurtzer GM, Sochat V, Bauer MW. Singularity: Scientific containers for mobility of compute. PLoS One. 2017 May 11;12(5):e0177459. doi: 10.1371/journal.pone.0177459. eCollection 2017. PubMed PMID: 28494014; PubMed Central PMCID: PMC5426675. diff --git a/README.md b/README.md index 28d5f8bec..71c912997 100644 --- a/README.md +++ b/README.md @@ -1,4 +1,4 @@ -# ![nf-core/chipseq](docs/images/nf-core-chipseq_logo_light.png#gh-light-mode-only) ![nf-core/chipseq](docs/images/nf-core-chipseq_logo_dark.png#gh-dark-mode-only) +# ![nf-core/chipseq](docs/images/nf-core/chipseq_logo_light.png#gh-light-mode-only) ![nf-core/chipseq](docs/images/nf-core/chipseq_logo_dark.png#gh-dark-mode-only) [![GitHub Actions CI Status](https://github.com/nf-core/chipseq/workflows/nf-core%20CI/badge.svg)](https://github.com/nf-core/chipseq/actions?query=workflow%3A%22nf-core+CI%22) [![GitHub Actions Linting Status](https://github.com/nf-core/chipseq/workflows/nf-core%20linting/badge.svg)](https://github.com/nf-core/chipseq/actions?query=workflow%3A%22nf-core+linting%22) @@ -17,11 +17,13 @@ ## Introduction + **nf-core/chipseq** is a bioinformatics best-practice analysis pipeline for ChIP-seq peak-calling and differential analysis pipeline.. The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool to run tasks across multiple compute infrastructures in a very portable manner. It uses Docker/Singularity containers making installation trivial and results highly reproducible. The [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) implementation of this pipeline uses one container per process which makes it much easier to maintain and update software dependencies. Where possible, these processes have been submitted to and installed from [nf-core/modules](https://github.com/nf-core/modules) in order to make them available to all nf-core pipelines, and to everyone within the Nextflow community! + On release, automated continuous integration tests run the pipeline on a full-sized dataset on the AWS cloud infrastructure. This ensures that the pipeline runs on AWS, has sensible resource allocation defaults set to run on real-world datasets, and permits the persistent storage of results to benchmark between pipeline releases and other analysis sources. The results obtained from the full-sized test can be viewed on the [nf-core website](https://nf-co.re/chipseq/results). ## Pipeline summary @@ -35,28 +37,28 @@ On release, automated continuous integration tests run the pipeline on a full-si 1. Install [`Nextflow`](https://www.nextflow.io/docs/latest/getstarted.html#installation) (`>=21.10.3`) -2. Install any of [`Docker`](https://docs.docker.com/engine/installation/), [`Singularity`](https://www.sylabs.io/guides/3.0/user-guide/), [`Podman`](https://podman.io/), [`Shifter`](https://nersc.gitlab.io/development/shifter/how-to-use/) or [`Charliecloud`](https://hpc.github.io/charliecloud/) for full pipeline reproducibility _(please only use [`Conda`](https://conda.io/miniconda.html) as a last resort; see [docs](https://nf-co.re/usage/configuration#basic-configuration-profiles))_ +2. Install any of [`Docker`](https://docs.docker.com/engine/installation/), [`Singularity`](https://www.sylabs.io/guides/3.0/user-guide/) (you can follow [this tutorial](https://singularity-tutorial.github.io/01-installation/)), [`Podman`](https://podman.io/), [`Shifter`](https://nersc.gitlab.io/development/shifter/how-to-use/) or [`Charliecloud`](https://hpc.github.io/charliecloud/) for full pipeline reproducibility _(you can use [`Conda`](https://conda.io/miniconda.html) both to install Nextflow itself and also to manage software within pipelines. Please only use it within pipelines as a last resort; see [docs](https://nf-co.re/usage/configuration#basic-configuration-profiles))_. 3. Download the pipeline and test it on a minimal dataset with a single command: - ```console - nextflow run nf-core/chipseq -profile test,YOURPROFILE --outdir - ``` + ```console + nextflow run nf-core/chipseq -profile test,YOURPROFILE --outdir + ``` - Note that some form of configuration will be needed so that Nextflow knows how to fetch the required software. This is usually done in the form of a config profile (`YOURPROFILE` in the example command above). You can chain multiple config profiles in a comma-separated string. + Note that some form of configuration will be needed so that Nextflow knows how to fetch the required software. This is usually done in the form of a config profile (`YOURPROFILE` in the example command above). You can chain multiple config profiles in a comma-separated string. - > * The pipeline comes with config profiles called `docker`, `singularity`, `podman`, `shifter`, `charliecloud` and `conda` which instruct the pipeline to use the named tool for software management. For example, `-profile test,docker`. - > * Please check [nf-core/configs](https://github.com/nf-core/configs#documentation) to see if a custom config file to run nf-core pipelines already exists for your Institute. If so, you can simply use `-profile ` in your command. This will enable either `docker` or `singularity` and set the appropriate execution settings for your local compute environment. - > * If you are using `singularity`, please use the [`nf-core download`](https://nf-co.re/tools/#downloading-pipelines-for-offline-use) command to download images first, before running the pipeline. Setting the [`NXF_SINGULARITY_CACHEDIR` or `singularity.cacheDir`](https://www.nextflow.io/docs/latest/singularity.html?#singularity-docker-hub) Nextflow options enables you to store and re-use the images from a central location for future pipeline runs. - > * If you are using `conda`, it is highly recommended to use the [`NXF_CONDA_CACHEDIR` or `conda.cacheDir`](https://www.nextflow.io/docs/latest/conda.html) settings to store the environments in a central location for future pipeline runs. + > - The pipeline comes with config profiles called `docker`, `singularity`, `podman`, `shifter`, `charliecloud` and `conda` which instruct the pipeline to use the named tool for software management. For example, `-profile test,docker`. + > - Please check [nf-core/configs](https://github.com/nf-core/configs#documentation) to see if a custom config file to run nf-core pipelines already exists for your Institute. If so, you can simply use `-profile ` in your command. This will enable either `docker` or `singularity` and set the appropriate execution settings for your local compute environment. + > - If you are using `singularity`, please use the [`nf-core download`](https://nf-co.re/tools/#downloading-pipelines-for-offline-use) command to download images first, before running the pipeline. Setting the [`NXF_SINGULARITY_CACHEDIR` or `singularity.cacheDir`](https://www.nextflow.io/docs/latest/singularity.html?#singularity-docker-hub) Nextflow options enables you to store and re-use the images from a central location for future pipeline runs. + > - If you are using `conda`, it is highly recommended to use the [`NXF_CONDA_CACHEDIR` or `conda.cacheDir`](https://www.nextflow.io/docs/latest/conda.html) settings to store the environments in a central location for future pipeline runs. 4. Start running your own analysis! - + - ```console - nextflow run nf-core/chipseq --input samplesheet.csv --outdir --genome GRCh37 -profile - ``` + ```console + nextflow run nf-core/chipseq --input samplesheet.csv --outdir --genome GRCh37 -profile + ``` ## Documentation @@ -82,6 +84,7 @@ For further information or help, don't hesitate to get in touch on the [Slack `# + An extensive list of references for the tools used by the pipeline can be found in the [`CITATIONS.md`](CITATIONS.md) file. You can cite the `nf-core` publication as follows: diff --git a/assets/email_template.html b/assets/email_template.html index 5a4548bb0..5c35a97ba 100644 --- a/assets/email_template.html +++ b/assets/email_template.html @@ -1,53 +1,111 @@ - - - - + + + + - - nf-core/chipseq Pipeline Report - - -

+ + + nf-core/chipseq Pipeline Report + + +
+ - +

nf-core/chipseq v${version}

+

Run Name: $runName

-

nf-core/chipseq v${version}

-

Run Name: $runName

- -<% if (!success){ - out << """ -
-

nf-core/chipseq execution completed unsuccessfully!

+ <% if (!success){ out << """ +
+

nf-core/chipseq execution completed unsuccessfully!

The exit status of the task that caused the workflow execution to fail was: $exitStatus.

The full error message was:

- 
${errorReport}
-
- """ -} else { - out << """ -
+ 
${errorReport}
+
+ """ } else { out << """ +
nf-core/chipseq execution completed successfully! -
- """ -} -%> +
+ """ } %> -

The workflow was completed at $dateComplete (duration: $duration)

-

The command used to launch the workflow was as follows:

-
$commandLine
+

The workflow was completed at $dateComplete (duration: $duration)

+

The command used to launch the workflow was as follows:

+ 
+$commandLine
-

Pipeline Configuration:

- - - <% out << summary.collect{ k,v -> "" }.join("\n") %> - -
$k
$v
+

Pipeline Configuration:

+ + + <% out << summary.collect{ k,v -> " + + + + + " }.join("\n") %> + +
+ $k + + 
$v
+
-

nf-core/chipseq

-

https://github.com/nf-core/chipseq

- -
- - +

nf-core/chipseq

+

https://github.com/nf-core/chipseq

+
+ diff --git a/assets/multiqc_config.yaml b/assets/multiqc_config.yaml deleted file mode 100644 index b7c276e1b..000000000 --- a/assets/multiqc_config.yaml +++ /dev/null @@ -1,11 +0,0 @@ -report_comment: > - This report has been generated by the nf-core/chipseq - analysis pipeline. For information about how to interpret these results, please see the - documentation. -report_section_order: - software_versions: - order: -1000 - nf-core-chipseq-summary: - order: -1001 - -export_plots: true diff --git a/assets/multiqc_config.yml b/assets/multiqc_config.yml new file mode 100644 index 000000000..5b7d16528 --- /dev/null +++ b/assets/multiqc_config.yml @@ -0,0 +1,11 @@ +report_comment: > + This report has been generated by the nf-core/chipseq + analysis pipeline. For information about how to interpret these results, please see the + documentation. +report_section_order: + software_versions: + order: -1000 + "nf-core-chipseq-summary": + order: -1001 + +export_plots: true diff --git a/assets/schema_input.json b/assets/schema_input.json index a024fd708..20b4e844b 100644 --- a/assets/schema_input.json +++ b/assets/schema_input.json @@ -31,9 +31,6 @@ ] } }, - "required": [ - "sample", - "fastq_1" - ] + "required": ["sample", "fastq_1"] } } diff --git a/docs/README.md b/docs/README.md index ac8a8b69c..d3849f4fe 100644 --- a/docs/README.md +++ b/docs/README.md @@ -2,9 +2,9 @@ The nf-core/chipseq documentation is split into the following pages: -* [Usage](usage.md) - * An overview of how the pipeline works, how to run it and a description of all of the different command-line flags. -* [Output](output.md) - * An overview of the different results produced by the pipeline and how to interpret them. +- [Usage](usage.md) + - An overview of how the pipeline works, how to run it and a description of all of the different command-line flags. +- [Output](output.md) + - An overview of the different results produced by the pipeline and how to interpret them. You can find a lot more documentation about installing, configuring and running nf-core pipelines on the website: [https://nf-co.re](https://nf-co.re) diff --git a/docs/output.md b/docs/output.md index b9c8a3df6..d0fe3e904 100644 --- a/docs/output.md +++ b/docs/output.md @@ -12,18 +12,18 @@ The directories listed below will be created in the results directory after the The pipeline is built using [Nextflow](https://www.nextflow.io/) and processes data using the following steps: -* [FastQC](#fastqc) - Raw read QC -* [MultiQC](#multiqc) - Aggregate report describing results and QC from the whole pipeline -* [Pipeline information](#pipeline-information) - Report metrics generated during the workflow execution +- [FastQC](#fastqc) - Raw read QC +- [MultiQC](#multiqc) - Aggregate report describing results and QC from the whole pipeline +- [Pipeline information](#pipeline-information) - Report metrics generated during the workflow execution ### FastQC
Output files -* `fastqc/` - * `*_fastqc.html`: FastQC report containing quality metrics. - * `*_fastqc.zip`: Zip archive containing the FastQC report, tab-delimited data file and plot images. +- `fastqc/` + - `*_fastqc.html`: FastQC report containing quality metrics. + - `*_fastqc.zip`: Zip archive containing the FastQC report, tab-delimited data file and plot images.
@@ -42,10 +42,10 @@ The pipeline is built using [Nextflow](https://www.nextflow.io/) and processes d
Output files -* `multiqc/` - * `multiqc_report.html`: a standalone HTML file that can be viewed in your web browser. - * `multiqc_data/`: directory containing parsed statistics from the different tools used in the pipeline. - * `multiqc_plots/`: directory containing static images from the report in various formats. +- `multiqc/` + - `multiqc_report.html`: a standalone HTML file that can be viewed in your web browser. + - `multiqc_data/`: directory containing parsed statistics from the different tools used in the pipeline. + - `multiqc_plots/`: directory containing static images from the report in various formats.
@@ -58,10 +58,10 @@ Results generated by MultiQC collate pipeline QC from supported tools e.g. FastQ
Output files -* `pipeline_info/` - * Reports generated by Nextflow: `execution_report.html`, `execution_timeline.html`, `execution_trace.txt` and `pipeline_dag.dot`/`pipeline_dag.svg`. - * Reports generated by the pipeline: `pipeline_report.html`, `pipeline_report.txt` and `software_versions.yml`. The `pipeline_report*` files will only be present if the `--email` / `--email_on_fail` parameter's are used when running the pipeline. - * Reformatted samplesheet files used as input to the pipeline: `samplesheet.valid.csv`. +- `pipeline_info/` + - Reports generated by Nextflow: `execution_report.html`, `execution_timeline.html`, `execution_trace.txt` and `pipeline_dag.dot`/`pipeline_dag.svg`. + - Reports generated by the pipeline: `pipeline_report.html`, `pipeline_report.txt` and `software_versions.yml`. The `pipeline_report*` files will only be present if the `--email` / `--email_on_fail` parameter's are used when running the pipeline. + - Reformatted samplesheet files used as input to the pipeline: `samplesheet.valid.csv`.
diff --git a/docs/usage.md b/docs/usage.md index 0a8f0ebd0..e6dc9daa9 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -44,11 +44,11 @@ TREATMENT_REP3,AEG588A6_S6_L003_R1_001.fastq.gz, TREATMENT_REP3,AEG588A6_S6_L004_R1_001.fastq.gz, ``` -| Column | Description | -|----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------| -| `sample` | Custom sample name. This entry will be identical for multiple sequencing libraries/runs from the same sample. Spaces in sample names are automatically converted to underscores (`_`). | -| `fastq_1` | Full path to FastQ file for Illumina short reads 1. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | -| `fastq_2` | Full path to FastQ file for Illumina short reads 2. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | +| Column | Description | +| --------- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | +| `sample` | Custom sample name. This entry will be identical for multiple sequencing libraries/runs from the same sample. Spaces in sample names are automatically converted to underscores (`_`). | +| `fastq_1` | Full path to FastQ file for Illumina short reads 1. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | +| `fastq_2` | Full path to FastQ file for Illumina short reads 2. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | An [example samplesheet](../assets/samplesheet.csv) has been provided with the pipeline. @@ -57,7 +57,7 @@ An [example samplesheet](../assets/samplesheet.csv) has been provided with the p The typical command for running the pipeline is as follows: ```console -nextflow run nf-core/chipseq --input samplesheet.csv --outdir --genome GRCh37 -profile docker +nextflow run nf-core/chipseq --input samplesheet.csv --outdir --genome GRCh37 -profile docker ``` This will launch the pipeline with the `docker` configuration profile. See below for more information about profiles. @@ -65,9 +65,9 @@ This will launch the pipeline with the `docker` configuration profile. See below Note that the pipeline will create the following files in your working directory: ```console -work # Directory containing the nextflow working files -results # Finished results (configurable, see below) -.nextflow_log # Log file from Nextflow +work # Directory containing the nextflow working files + # Finished results in specified location (defined with --outdir) +.nextflow_log # Log file from Nextflow # Other nextflow hidden files, eg. history of pipeline runs and old logs. ``` @@ -106,25 +106,25 @@ They are loaded in sequence, so later profiles can overwrite earlier profiles. If `-profile` is not specified, the pipeline will run locally and expect all software to be installed and available on the `PATH`. This is _not_ recommended. -* `docker` - * A generic configuration profile to be used with [Docker](https://docker.com/) -* `singularity` - * A generic configuration profile to be used with [Singularity](https://sylabs.io/docs/) -* `podman` - * A generic configuration profile to be used with [Podman](https://podman.io/) -* `shifter` - * A generic configuration profile to be used with [Shifter](https://nersc.gitlab.io/development/shifter/how-to-use/) -* `charliecloud` - * A generic configuration profile to be used with [Charliecloud](https://hpc.github.io/charliecloud/) -* `conda` - * A generic configuration profile to be used with [Conda](https://conda.io/docs/). Please only use Conda as a last resort i.e. when it's not possible to run the pipeline with Docker, Singularity, Podman, Shifter or Charliecloud. -* `test` - * A profile with a complete configuration for automated testing - * Includes links to test data so needs no other parameters +- `docker` + - A generic configuration profile to be used with [Docker](https://docker.com/) +- `singularity` + - A generic configuration profile to be used with [Singularity](https://sylabs.io/docs/) +- `podman` + - A generic configuration profile to be used with [Podman](https://podman.io/) +- `shifter` + - A generic configuration profile to be used with [Shifter](https://nersc.gitlab.io/development/shifter/how-to-use/) +- `charliecloud` + - A generic configuration profile to be used with [Charliecloud](https://hpc.github.io/charliecloud/) +- `conda` + - A generic configuration profile to be used with [Conda](https://conda.io/docs/). Please only use Conda as a last resort i.e. when it's not possible to run the pipeline with Docker, Singularity, Podman, Shifter or Charliecloud. +- `test` + - A profile with a complete configuration for automated testing + - Includes links to test data so needs no other parameters ### `-resume` -Specify this when restarting a pipeline. Nextflow will used cached results from any pipeline steps where the inputs are the same, continuing from where it got to previously. +Specify this when restarting a pipeline. Nextflow will use cached results from any pipeline steps where the inputs are the same, continuing from where it got to previously. For input to be considered the same, not only the names must be identical but the files' contents as well. For more info about this parameter, see [this blog post](https://www.nextflow.io/blog/2019/demystifying-nextflow-resume.html). You can also supply a run name to resume a specific run: `-resume [run-name]`. Use the `nextflow log` command to show previous run names. @@ -186,6 +186,7 @@ process { ``` > **NB:** We specify the full process name i.e. `NFCORE_RNASEQ:RNASEQ:ALIGN_STAR:STAR_ALIGN` in the config file because this takes priority over the short name (`STAR_ALIGN`) and allows existing configuration using the full process name to be correctly overridden. +> > If you get a warning suggesting that the process selector isn't recognised check that the process name has been specified correctly. ### Updating containers @@ -196,35 +197,35 @@ The [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) implementatio 2. Find the latest version of the Biocontainer available on [Quay.io](https://quay.io/repository/biocontainers/pangolin?tag=latest&tab=tags) 3. Create the custom config accordingly: - * For Docker: - - ```nextflow - process { - withName: PANGOLIN { - container = 'quay.io/biocontainers/pangolin:3.0.5--pyhdfd78af_0' - } - } - ``` - - * For Singularity: - - ```nextflow - process { - withName: PANGOLIN { - container = 'https://depot.galaxyproject.org/singularity/pangolin:3.0.5--pyhdfd78af_0' - } - } - ``` - - * For Conda: - - ```nextflow - process { - withName: PANGOLIN { - conda = 'bioconda::pangolin=3.0.5' - } - } - ``` + - For Docker: + + ```nextflow + process { + withName: PANGOLIN { + container = 'quay.io/biocontainers/pangolin:3.0.5--pyhdfd78af_0' + } + } + ``` + + - For Singularity: + + ```nextflow + process { + withName: PANGOLIN { + container = 'https://depot.galaxyproject.org/singularity/pangolin:3.0.5--pyhdfd78af_0' + } + } + ``` + + - For Conda: + + ```nextflow + process { + withName: PANGOLIN { + conda = 'bioconda::pangolin=3.0.5' + } + } + ``` > **NB:** If you wish to periodically update individual tool-specific results (e.g. Pangolin) generated by the pipeline then you must ensure to keep the `work/` directory otherwise the `-resume` ability of the pipeline will be compromised and it will restart from scratch. diff --git a/modules.json b/modules.json index 072fc172e..72584e8a4 100644 --- a/modules.json +++ b/modules.json @@ -4,14 +4,14 @@ "repos": { "nf-core/modules": { "custom/dumpsoftwareversions": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "fastqc": { - "git_sha": "9d0cad583b9a71a6509b754fdf589cbfbed08961" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "multiqc": { - "git_sha": "20d8250d9f39ddb05dfb437603aaf99b5c0b2b41" + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" } } } -} \ No newline at end of file +} diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf b/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf index 934bb4672..327d51005 100644 --- a/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf @@ -15,6 +15,9 @@ process CUSTOM_DUMPSOFTWAREVERSIONS { path "software_versions_mqc.yml", emit: mqc_yml path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' template 'dumpsoftwareversions.py' diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml b/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml index 5b5b8a602..60b546a01 100644 --- a/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/meta.yml @@ -8,7 +8,7 @@ tools: description: Custom module used to dump software versions within the nf-core pipeline template homepage: https://github.com/nf-core/tools documentation: https://github.com/nf-core/tools - licence: ['MIT'] + licence: ["MIT"] input: - versions: type: file diff --git a/modules/nf-core/modules/fastqc/main.nf b/modules/nf-core/modules/fastqc/main.nf index d250eca07..ed6b8c50b 100644 --- a/modules/nf-core/modules/fastqc/main.nf +++ b/modules/nf-core/modules/fastqc/main.nf @@ -15,6 +15,9 @@ process FASTQC { tuple val(meta), path("*.zip") , emit: zip path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' // Add soft-links to original FastQs for consistent naming in pipeline diff --git a/modules/nf-core/modules/fastqc/meta.yml b/modules/nf-core/modules/fastqc/meta.yml index b09553a3c..4da5bb5a0 100644 --- a/modules/nf-core/modules/fastqc/meta.yml +++ b/modules/nf-core/modules/fastqc/meta.yml @@ -1,52 +1,52 @@ name: fastqc description: Run FastQC on sequenced reads keywords: - - quality control - - qc - - adapters - - fastq + - quality control + - qc + - adapters + - fastq tools: - - fastqc: - description: | - FastQC gives general quality metrics about your reads. - It provides information about the quality score distribution - across your reads, the per base sequence content (%A/C/G/T). - You get information about adapter contamination and other - overrepresented sequences. - homepage: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/ - documentation: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/ - licence: ['GPL-2.0-only'] + - fastqc: + description: | + FastQC gives general quality metrics about your reads. + It provides information about the quality score distribution + across your reads, the per base sequence content (%A/C/G/T). + You get information about adapter contamination and other + overrepresented sequences. + homepage: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/ + documentation: https://www.bioinformatics.babraham.ac.uk/projects/fastqc/Help/ + licence: ["GPL-2.0-only"] input: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - reads: - type: file - description: | - List of input FastQ files of size 1 and 2 for single-end and paired-end data, - respectively. + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - reads: + type: file + description: | + List of input FastQ files of size 1 and 2 for single-end and paired-end data, + respectively. output: - - meta: - type: map - description: | - Groovy Map containing sample information - e.g. [ id:'test', single_end:false ] - - html: - type: file - description: FastQC report - pattern: "*_{fastqc.html}" - - zip: - type: file - description: FastQC report archive - pattern: "*_{fastqc.zip}" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - html: + type: file + description: FastQC report + pattern: "*_{fastqc.html}" + - zip: + type: file + description: FastQC report archive + pattern: "*_{fastqc.zip}" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@drpatelh" - - "@grst" - - "@ewels" - - "@FelixKrueger" + - "@drpatelh" + - "@grst" + - "@ewels" + - "@FelixKrueger" diff --git a/modules/nf-core/modules/multiqc/main.nf b/modules/nf-core/modules/multiqc/main.nf index 3dceb162a..1264aac1e 100644 --- a/modules/nf-core/modules/multiqc/main.nf +++ b/modules/nf-core/modules/multiqc/main.nf @@ -1,10 +1,10 @@ process MULTIQC { label 'process_medium' - conda (params.enable_conda ? 'bioconda::multiqc=1.11' : null) + conda (params.enable_conda ? 'bioconda::multiqc=1.12' : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/multiqc:1.11--pyhdfd78af_0' : - 'quay.io/biocontainers/multiqc:1.11--pyhdfd78af_0' }" + 'https://depot.galaxyproject.org/singularity/multiqc:1.12--pyhdfd78af_0' : + 'quay.io/biocontainers/multiqc:1.12--pyhdfd78af_0' }" input: path multiqc_files @@ -15,6 +15,9 @@ process MULTIQC { path "*_plots" , optional:true, emit: plots path "versions.yml" , emit: versions + when: + task.ext.when == null || task.ext.when + script: def args = task.ext.args ?: '' """ diff --git a/modules/nf-core/modules/multiqc/meta.yml b/modules/nf-core/modules/multiqc/meta.yml index 63c75a450..6fa891efc 100644 --- a/modules/nf-core/modules/multiqc/meta.yml +++ b/modules/nf-core/modules/multiqc/meta.yml @@ -1,40 +1,40 @@ name: MultiQC description: Aggregate results from bioinformatics analyses across many samples into a single report keywords: - - QC - - bioinformatics tools - - Beautiful stand-alone HTML report + - QC + - bioinformatics tools + - Beautiful stand-alone HTML report tools: - - multiqc: - description: | - MultiQC searches a given directory for analysis logs and compiles a HTML report. - It's a general use tool, perfect for summarising the output from numerous bioinformatics tools. - homepage: https://multiqc.info/ - documentation: https://multiqc.info/docs/ - licence: ['GPL-3.0-or-later'] + - multiqc: + description: | + MultiQC searches a given directory for analysis logs and compiles a HTML report. + It's a general use tool, perfect for summarising the output from numerous bioinformatics tools. + homepage: https://multiqc.info/ + documentation: https://multiqc.info/docs/ + licence: ["GPL-3.0-or-later"] input: - - multiqc_files: - type: file - description: | - List of reports / files recognised by MultiQC, for example the html and zip output of FastQC + - multiqc_files: + type: file + description: | + List of reports / files recognised by MultiQC, for example the html and zip output of FastQC output: - - report: - type: file - description: MultiQC report file - pattern: "multiqc_report.html" - - data: - type: dir - description: MultiQC data dir - pattern: "multiqc_data" - - plots: - type: file - description: Plots created by MultiQC - pattern: "*_data" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" + - report: + type: file + description: MultiQC report file + pattern: "multiqc_report.html" + - data: + type: dir + description: MultiQC data dir + pattern: "multiqc_data" + - plots: + type: file + description: Plots created by MultiQC + pattern: "*_data" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" authors: - - "@abhi18av" - - "@bunop" - - "@drpatelh" + - "@abhi18av" + - "@bunop" + - "@drpatelh" diff --git a/nextflow_schema.json b/nextflow_schema.json index 0ae1bfc8f..8080b723a 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -10,10 +10,7 @@ "type": "object", "fa_icon": "fas fa-terminal", "description": "Define where the pipeline should find input data and save output data.", - "required": [ - "input", - "outdir" - ], + "required": ["input", "outdir"], "properties": { "input": { "type": "string", @@ -185,14 +182,7 @@ "description": "Method used to save pipeline results to output directory.", "help_text": "The Nextflow `publishDir` option specifies which intermediate files should be saved to the output directory. This option tells the pipeline what method should be used to move these files. See [Nextflow docs](https://www.nextflow.io/docs/latest/process.html#publishdir) for details.", "fa_icon": "fas fa-copy", - "enum": [ - "symlink", - "rellink", - "link", - "copy", - "copyNoFollow", - "move" - ], + "enum": ["symlink", "rellink", "link", "copy", "copyNoFollow", "move"], "hidden": true }, "email_on_fail": { diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 0a51968e9..ea403618f 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -23,7 +23,7 @@ if (params.input) { ch_input = file(params.input) } else { exit 1, 'Input sample ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ -ch_multiqc_config = file("$projectDir/assets/multiqc_config.yaml", checkIfExists: true) +ch_multiqc_config = file("$projectDir/assets/multiqc_config.yml", checkIfExists: true) ch_multiqc_custom_config = params.multiqc_config ? Channel.fromPath(params.multiqc_config) : Channel.empty() /* From d9f7f50dfca1d01392dfbc16e11beee9b306fbec Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Thu, 24 Mar 2022 11:33:34 +0000 Subject: [PATCH 354/538] Template update for nf-core/tools version 2.3.2 --- .github/PULL_REQUEST_TEMPLATE.md | 1 - .github/workflows/awsfulltest.yml | 2 -- .github/workflows/awstest.yml | 2 -- .gitpod.yml | 2 +- CHANGELOG.md | 2 -- 5 files changed, 1 insertion(+), 8 deletions(-) diff --git a/.github/PULL_REQUEST_TEMPLATE.md b/.github/PULL_REQUEST_TEMPLATE.md index a847bce64..9595a3a41 100644 --- a/.github/PULL_REQUEST_TEMPLATE.md +++ b/.github/PULL_REQUEST_TEMPLATE.md @@ -10,7 +10,6 @@ Remember that PRs should be made against the dev branch, unless you're preparing Learn more about contributing: [CONTRIBUTING.md](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) --> - ## PR checklist diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index 32c4519c5..700ff9000 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -22,8 +22,6 @@ jobs: workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }} access_token: ${{ secrets.TOWER_ACCESS_TOKEN }} compute_env: ${{ secrets.TOWER_COMPUTE_ENV }} - pipeline: ${{ github.repository }} - revision: ${{ github.sha }} workdir: s3://${{ secrets.AWS_S3_BUCKET }}/work/chipseq/work-${{ github.sha }} parameters: | { diff --git a/.github/workflows/awstest.yml b/.github/workflows/awstest.yml index e63a3be6b..666c70a31 100644 --- a/.github/workflows/awstest.yml +++ b/.github/workflows/awstest.yml @@ -17,8 +17,6 @@ jobs: workspace_id: ${{ secrets.TOWER_WORKSPACE_ID }} access_token: ${{ secrets.TOWER_ACCESS_TOKEN }} compute_env: ${{ secrets.TOWER_COMPUTE_ENV }} - pipeline: ${{ github.repository }} - revision: ${{ github.sha }} workdir: s3://${{ secrets.AWS_S3_BUCKET }}/work/chipseq/work-${{ github.sha }} parameters: | { diff --git a/.gitpod.yml b/.gitpod.yml index c452ee93e..85d95ecc8 100644 --- a/.gitpod.yml +++ b/.gitpod.yml @@ -4,7 +4,7 @@ vscode: extensions: # based on nf-core.nf-core-extensionpack - codezombiech.gitignore # Language support for .gitignore files # - cssho.vscode-svgviewer # SVG viewer - - davidanson.vscode-markdownlint # Markdown/CommonMark linting and style checking for Visual Studio Code + - esbenp.prettier-vscode # Markdown/CommonMark linting and style checking for Visual Studio Code - eamodio.gitlens # Quickly glimpse into whom, why, and when a line or code block was changed - EditorConfig.EditorConfig # override user/workspace settings with settings found in .editorconfig files - Gruntfuggly.todo-tree # Display TODO and FIXME in a tree view in the activity bar diff --git a/CHANGELOG.md b/CHANGELOG.md index b21fe9d0c..bcbe42c1b 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -11,8 +11,6 @@ Initial release of nf-core/chipseq, created with the [nf-core](https://nf-co.re/ ### `Fixed` -- Clarified conda usage and added an installation tutorial for Singularity since the one on Syllabs' website uses an outdate version of GO Compiler - ### `Dependencies` ### `Deprecated` From 87169682c83dd41cf5cc1769585072493e98ad81 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 28 Mar 2022 12:36:50 +0200 Subject: [PATCH 355/538] Update nf-core.yml --- .nf-core.yml | 5 +++++ 1 file changed, 5 insertions(+) diff --git a/.nf-core.yml b/.nf-core.yml index 3805dc81c..1051e8c5f 100644 --- a/.nf-core.yml +++ b/.nf-core.yml @@ -1 +1,6 @@ repository_type: pipeline +lint: + files_unchanged: + - .github/workflows/branch.yml + - .github/workflows/linting_comment.yml + - .github/workflows/linting.yml From b8e36c0b7baac640da412b31350dc4f61da1f965 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 28 Mar 2022 14:59:08 +0200 Subject: [PATCH 356/538] Fix nf-core lint --- .nf-core.yml | 1 + 1 file changed, 1 insertion(+) diff --git a/.nf-core.yml b/.nf-core.yml index 1051e8c5f..b3e51cb81 100644 --- a/.nf-core.yml +++ b/.nf-core.yml @@ -4,3 +4,4 @@ lint: - .github/workflows/branch.yml - .github/workflows/linting_comment.yml - .github/workflows/linting.yml + - .github/PULL_REQUEST_TEMPLATE.md From b12a8296ce27e569b8a46e422656577e0db4c4e0 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 28 Mar 2022 14:59:19 +0200 Subject: [PATCH 357/538] Make happy prettier --- CHANGELOG.md | 238 +++++++------- CITATIONS.md | 136 ++++---- README.md | 44 +-- assets/bamtools_filter_pe.json | 17 +- assets/bamtools_filter_se.json | 9 +- assets/multiqc_config.yml | 304 +++++++++--------- docs/output.md | 161 +++++----- docs/usage.md | 18 +- .../nf-core/modules/macs2/callpeak/meta.yml | 3 +- nextflow_schema.json | 16 +- package-lock.json | 20 ++ package.json | 5 + 12 files changed, 498 insertions(+), 473 deletions(-) create mode 100644 package-lock.json create mode 100644 package.json diff --git a/CHANGELOG.md b/CHANGELOG.md index 6573b686e..1c0e90e01 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -7,32 +7,32 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 ### Enhancements & fixes -* Port pipeline to the updated Nextflow DSL2 syntax adopted on nf-core/modules - * Removed `--publish_dir_mode` as it is no longer required for the new syntax -* Bump minimum Nextflow version from `21.04.0` -> `21.10.3` -* Updated pipeline template to [nf-core/tools 2.2](https://github.com/nf-core/tools/releases/tag/2.2) -* Added `python3` shebang to appropriate scripts in `bin/` directory -* [[#160](https://github.com/nf-core/chipseq/issues/160)] - Add `bowtie2` and `star` as available aligners, via the `--aligner` parameter -* Update pipeline template to nf-core/tools `2.1` -* Add `--save_unaligned` parameter (only available for `bowtie2` and `star`) -* Update `igenomes.config` to fetch whole `BWAIndex/version0.6.0/` folder -* [[228](https://github.com/nf-core/chipseq/issues/228)] - Update blacklist bed files. -* [nf-core/tools#1415](https://github.com/nf-core/tools/issues/1415) - Make `--outdir` a mandatory parameter +- Port pipeline to the updated Nextflow DSL2 syntax adopted on nf-core/modules + - Removed `--publish_dir_mode` as it is no longer required for the new syntax +- Bump minimum Nextflow version from `21.04.0` -> `21.10.3` +- Updated pipeline template to [nf-core/tools 2.2](https://github.com/nf-core/tools/releases/tag/2.2) +- Added `python3` shebang to appropriate scripts in `bin/` directory +- [[#160](https://github.com/nf-core/chipseq/issues/160)] - Add `bowtie2` and `star` as available aligners, via the `--aligner` parameter +- Update pipeline template to nf-core/tools `2.1` +- Add `--save_unaligned` parameter (only available for `bowtie2` and `star`) +- Update `igenomes.config` to fetch whole `BWAIndex/version0.6.0/` folder +- [[228](https://github.com/nf-core/chipseq/issues/228)] - Update blacklist bed files. +- [nf-core/tools#1415](https://github.com/nf-core/tools/issues/1415) - Make `--outdir` a mandatory parameter ### Parameters -| Old parameter | New parameter | -|------------------------------|----------------------------| -| `--clusterOptions` | | -| `--conda` | `--enable_conda` | -| | `--skip_qc` | -| | `--aligner` | -| | `--save_unaligned` | -| `--skip_diff_analysis` | `--skip_deseq2_qc` | +| Old parameter | New parameter | +| ---------------------- | ------------------ | +| `--clusterOptions` | | +| `--conda` | `--enable_conda` | +| | `--skip_qc` | +| | `--aligner` | +| | `--save_unaligned` | +| `--skip_diff_analysis` | `--skip_deseq2_qc` | -> __NB:__ Parameter has been __updated__ if both old and new parameter information is present. -> __NB:__ Parameter has been __added__ if just the new parameter information is present. -> __NB:__ Parameter has been __removed__ if parameter information isn't present. +> **NB:** Parameter has been **updated** if both old and new parameter information is present. +> **NB:** Parameter has been **added** if just the new parameter information is present. +> **NB:** Parameter has been **removed** if parameter information isn't present. ### Software dependencies @@ -63,130 +63,130 @@ TODO: update all new dependencies --> -> __NB:__ Dependency has been __updated__ if both old and new version information is present. -> __NB:__ Dependency has been __added__ if just the new version information is present. -> __NB:__ Dependency has been __removed__ if version information isn't present. +> **NB:** Dependency has been **updated** if both old and new version information is present. +> **NB:** Dependency has been **added** if just the new version information is present. +> **NB:** Dependency has been **removed** if version information isn't present. ## [1.2.2] - 2021-04-22 -* [#206](https://github.com/nf-core/chipseq/issues/206) - Minor patch release to fix Conda environment +- [#206](https://github.com/nf-core/chipseq/issues/206) - Minor patch release to fix Conda environment ### `Dependencies` -* Update r-base `3.6.2` -> `3.6.3` -* Update r-xfun `0.15` -> `0.20` +- Update r-base `3.6.2` -> `3.6.3` +- Update r-xfun `0.15` -> `0.20` ## [1.2.1] - 2020-07-29 -* [#171](https://github.com/nf-core/chipseq/issues/171) - Minor patch release to update pipeline schema +- [#171](https://github.com/nf-core/chipseq/issues/171) - Minor patch release to update pipeline schema ## [1.2.0] - 2020-07-02 ### `Added` -* [#138](https://github.com/nf-core/chipseq/issues/138) - Add social preview image -* [#153](https://github.com/nf-core/chipseq/issues/153) - Add plotHeatmap -* [#159](https://github.com/nf-core/chipseq/issues/159) - expose bwa mem -T parameter -* [nf-core/atacseq#63](https://github.com/nf-core/atacseq/issues/63) - Added multicore support for Trim Galore! -* [nf-core/atacseq#75](https://github.com/nf-core/atacseq/issues/75) - Include gene annotation versions in multiqc report -* [nf-core/atacseq#76](https://github.com/nf-core/atacseq/issues/76) - featureCounts coupled to DESeq2 -* [nf-core/atacseq#79](https://github.com/nf-core/atacseq/issues/79) - Parallelize DESeq2 -* [nf-core/atacseq#97](https://github.com/nf-core/atacseq/issues/97) - PBC1, PBC2 from pipeline? -* [nf-core/atacseq#107](https://github.com/nf-core/atacseq/issues/107) - Add options to change MACS2 parameters -* Regenerated screenshots and added collapsible sections for output files in `docs/output.md` -* Update template to tools `1.9` -* Replace `set` with `tuple` and `file()` with `path()` in all processes -* Capitalise process names -* Parameters: - * `--bwa_min_score` to set minimum alignment score for BWA MEM - * `--macs_fdr` to provide FDR threshold for MACS2 peak calling - * `--macs_pvalue` to provide p-value threshold for MACS2 peak calling - * `--skip_peak_qc` to skip MACS2 peak QC plot generation - * `--skip_peak_annotation` to skip annotation of MACS2 and consensus peaks with HOMER - * `--skip_consensus_peaks` to skip consensus peak generation - * `--deseq2_vst` to use variance stabilizing transformation (VST) instead of regularized log transformation (rlog) with DESeq2 - * `--publish_dir_mode` to customise method of publishing results to output directory [nf-core/tools#585](https://github.com/nf-core/tools/issues/585) +- [#138](https://github.com/nf-core/chipseq/issues/138) - Add social preview image +- [#153](https://github.com/nf-core/chipseq/issues/153) - Add plotHeatmap +- [#159](https://github.com/nf-core/chipseq/issues/159) - expose bwa mem -T parameter +- [nf-core/atacseq#63](https://github.com/nf-core/atacseq/issues/63) - Added multicore support for Trim Galore! +- [nf-core/atacseq#75](https://github.com/nf-core/atacseq/issues/75) - Include gene annotation versions in multiqc report +- [nf-core/atacseq#76](https://github.com/nf-core/atacseq/issues/76) - featureCounts coupled to DESeq2 +- [nf-core/atacseq#79](https://github.com/nf-core/atacseq/issues/79) - Parallelize DESeq2 +- [nf-core/atacseq#97](https://github.com/nf-core/atacseq/issues/97) - PBC1, PBC2 from pipeline? +- [nf-core/atacseq#107](https://github.com/nf-core/atacseq/issues/107) - Add options to change MACS2 parameters +- Regenerated screenshots and added collapsible sections for output files in `docs/output.md` +- Update template to tools `1.9` +- Replace `set` with `tuple` and `file()` with `path()` in all processes +- Capitalise process names +- Parameters: + - `--bwa_min_score` to set minimum alignment score for BWA MEM + - `--macs_fdr` to provide FDR threshold for MACS2 peak calling + - `--macs_pvalue` to provide p-value threshold for MACS2 peak calling + - `--skip_peak_qc` to skip MACS2 peak QC plot generation + - `--skip_peak_annotation` to skip annotation of MACS2 and consensus peaks with HOMER + - `--skip_consensus_peaks` to skip consensus peak generation + - `--deseq2_vst` to use variance stabilizing transformation (VST) instead of regularized log transformation (rlog) with DESeq2 + - `--publish_dir_mode` to customise method of publishing results to output directory [nf-core/tools#585](https://github.com/nf-core/tools/issues/585) ### `Removed` -* `--tss_bed` parameter +- `--tss_bed` parameter ### `Fixed` -* [#118](https://github.com/nf-core/chipseq/issues/118) - Running on with SGE -* [#132](https://github.com/nf-core/chipseq/issues/132) - BigWig Error: sort: cannot create temporary file in '': Read-only file system -* [#154](https://github.com/nf-core/chipseq/issues/154) - computeMatrix.val.mat.gz files not zipped -* [nf-core/atacseq#71](https://github.com/nf-core/atacseq/issues/71) - consensus_peaks.mLb.clN.boolean.intersect.plot.pdf not generated -* [nf-core/atacseq#73](https://github.com/nf-core/atacseq/issues/73) - macs_annotatePeaks.mLb.clN.summary.txt file is not created -* [nf-core/atacseq#86](https://github.com/nf-core/atacseq/issues/86) - bug in the plot_homer_annotatepeaks.r script -* [nf-core/atacseq#102](https://github.com/nf-core/atacseq/issues/102) - Incorrect Group ID assigned by featurecounts_deseq2.r -* [nf-core/atacseq#109](https://github.com/nf-core/atacseq/issues/109) - Specify custom gtf but gene bed is not generated from that gtf? -* Make executables in `bin/` compatible with Python 3 +- [#118](https://github.com/nf-core/chipseq/issues/118) - Running on with SGE +- [#132](https://github.com/nf-core/chipseq/issues/132) - BigWig Error: sort: cannot create temporary file in '': Read-only file system +- [#154](https://github.com/nf-core/chipseq/issues/154) - computeMatrix.val.mat.gz files not zipped +- [nf-core/atacseq#71](https://github.com/nf-core/atacseq/issues/71) - consensus_peaks.mLb.clN.boolean.intersect.plot.pdf not generated +- [nf-core/atacseq#73](https://github.com/nf-core/atacseq/issues/73) - macs_annotatePeaks.mLb.clN.summary.txt file is not created +- [nf-core/atacseq#86](https://github.com/nf-core/atacseq/issues/86) - bug in the plot_homer_annotatepeaks.r script +- [nf-core/atacseq#102](https://github.com/nf-core/atacseq/issues/102) - Incorrect Group ID assigned by featurecounts_deseq2.r +- [nf-core/atacseq#109](https://github.com/nf-core/atacseq/issues/109) - Specify custom gtf but gene bed is not generated from that gtf? +- Make executables in `bin/` compatible with Python 3 ### `Dependencies` -* Add bioconductor-biocparallel `1.20.0` -* Add markdown `3.2.2` -* Add pigz `2.3.4` -* Add pygments `2.6.1` -* Add pymdown-extensions `7.1` -* Add python `3.7.6` -* Add r-reshape2 `1.4.4` -* Add r-tidyr `1.1.0` -* Update bedtools `2.27.1` -> `2.29.2` -* Update bioconductor-deseq2 `1.20.0` -> `1.26.0` -* Update bioconductor-vsn `3.46.0` -> `3.54.0` -* Update deeptools `3.2.1` -> `3.4.3` -* Update fastqc `0.11.8` -> `0.11.9` -* Update gawk `4.2.1` -> `5.1.0` -* Update homer `4.9.1` -> `4.11` -* Update macs2 `2.1.2` -> `2.2.7.1` -* Update multiqc `1.7` -> `1.8` -* Update phantompeakqualtools `1.2` -> `1.2.2` -* Update picard `2.19.0` -> `2.23.1` -* Update pysam `0.15.2` -> `0.15.3` -* Update r-base `3.4.1` -> `3.6.2` -* Update r-ggplot2 `3.1.0` -> `3.3.2` -* Update r-lattice `0.20_35` -> `0.20_41` -* Update r-optparse `1.6.0` -> `1.6.6` -* Update r-pheatmap `1.0.10` -> `1.0.12` -* Update r-scales `1.0.0` -> `1.1.1` -* Update r-upsetr `1.3.3` -> `1.4.0` -* Update r-xfun `0.3` -> `0.15` -* Update samtools `1.9` -> `1.10` -* Update subread `1.6.4` -> `2.0.1` -* Update trim-galore `0.5.0` -> `0.6.5` -* Update ucsc-bedgraphtobigwig `377` -> `357` +- Add bioconductor-biocparallel `1.20.0` +- Add markdown `3.2.2` +- Add pigz `2.3.4` +- Add pygments `2.6.1` +- Add pymdown-extensions `7.1` +- Add python `3.7.6` +- Add r-reshape2 `1.4.4` +- Add r-tidyr `1.1.0` +- Update bedtools `2.27.1` -> `2.29.2` +- Update bioconductor-deseq2 `1.20.0` -> `1.26.0` +- Update bioconductor-vsn `3.46.0` -> `3.54.0` +- Update deeptools `3.2.1` -> `3.4.3` +- Update fastqc `0.11.8` -> `0.11.9` +- Update gawk `4.2.1` -> `5.1.0` +- Update homer `4.9.1` -> `4.11` +- Update macs2 `2.1.2` -> `2.2.7.1` +- Update multiqc `1.7` -> `1.8` +- Update phantompeakqualtools `1.2` -> `1.2.2` +- Update picard `2.19.0` -> `2.23.1` +- Update pysam `0.15.2` -> `0.15.3` +- Update r-base `3.4.1` -> `3.6.2` +- Update r-ggplot2 `3.1.0` -> `3.3.2` +- Update r-lattice `0.20_35` -> `0.20_41` +- Update r-optparse `1.6.0` -> `1.6.6` +- Update r-pheatmap `1.0.10` -> `1.0.12` +- Update r-scales `1.0.0` -> `1.1.1` +- Update r-upsetr `1.3.3` -> `1.4.0` +- Update r-xfun `0.3` -> `0.15` +- Update samtools `1.9` -> `1.10` +- Update subread `1.6.4` -> `2.0.1` +- Update trim-galore `0.5.0` -> `0.6.5` +- Update ucsc-bedgraphtobigwig `377` -> `357` ## [1.1.0] - 2019-11-05 ### `Added` -* [nf-core/atacseq#46](https://github.com/nf-core/atacseq/issues/46) - Missing gene_bed path in igenomes config -* Update template to tools `1.7` -* Add `--trim_nextseq` parameter -* Add `CITATIONS.md` file -* Capitalised process names +- [nf-core/atacseq#46](https://github.com/nf-core/atacseq/issues/46) - Missing gene_bed path in igenomes config +- Update template to tools `1.7` +- Add `--trim_nextseq` parameter +- Add `CITATIONS.md` file +- Capitalised process names ### `Fixed` -* Change all parameters from `camelCase` to `snake_case` (see [Deprecated](#Deprecated)) -* [nf-core/atacseq#44](https://github.com/nf-core/atacseq/issues/44) - Output directory missing: macs2/consensus/deseq2 -* [nf-core/atacseq#45](https://github.com/nf-core/atacseq/issues/45) - Wrong x-axis scale for the HOMER: Peak annotation Counts tab plot? -* [nf-core/atacseq#46](https://github.com/nf-core/atacseq/issues/46) - Stage blacklist file in channel properly -* [nf-core/atacseq#50](https://github.com/nf-core/atacseq/issues/50) - HOMER number of peaks does not correspond to found MACS2 peaks -* Fixed bug in UpSetR peak intersection plot -* Increase default resource requirements in `base.config` -* Increase process-specific requirements based on user-reported failures +- Change all parameters from `camelCase` to `snake_case` (see [Deprecated](#Deprecated)) +- [nf-core/atacseq#44](https://github.com/nf-core/atacseq/issues/44) - Output directory missing: macs2/consensus/deseq2 +- [nf-core/atacseq#45](https://github.com/nf-core/atacseq/issues/45) - Wrong x-axis scale for the HOMER: Peak annotation Counts tab plot? +- [nf-core/atacseq#46](https://github.com/nf-core/atacseq/issues/46) - Stage blacklist file in channel properly +- [nf-core/atacseq#50](https://github.com/nf-core/atacseq/issues/50) - HOMER number of peaks does not correspond to found MACS2 peaks +- Fixed bug in UpSetR peak intersection plot +- Increase default resource requirements in `base.config` +- Increase process-specific requirements based on user-reported failures ### `Dependencies` -* Update Nextflow `0.32.0` -> `19.10.0` +- Update Nextflow `0.32.0` -> `19.10.0` ### `Deprecated` | Deprecated | Replacement | -|------------------------------|---------------------------| +| ---------------------------- | ------------------------- | | `--design` | `--input` | | `--singleEnd` | `--single_end` | | `--saveGenomeIndex` | `--save_reference` | @@ -213,14 +213,14 @@ Initial release of nf-core/chipseq pipeline. ### `Added` -* Raw read QC (FastQC) -* Adapter trimming (Trim Galore!) -* Map and filter reads (BWA, picard, SAMtools, BEDTools, BAMTools, Pysam) -* Create library-size normalised bigWig tracks (BEDTools, bedGraphToBigWig) -* Alignment QC metrics (Preseq, picard) -* ChIP-seq QC metrics (deepTools, phantompeakqualtools) -* Call and annotate broad/narrow peaks (MACS2, HOMER) -* Create consensus set of peaks per antibody (BEDTools) -* Quantification and differential binding analysis (featureCounts, DESeq2) -* Collate appropriate files for genome browser visualisation (IGV) -* Collate and present various QC metrics (MultiQC, R) +- Raw read QC (FastQC) +- Adapter trimming (Trim Galore!) +- Map and filter reads (BWA, picard, SAMtools, BEDTools, BAMTools, Pysam) +- Create library-size normalised bigWig tracks (BEDTools, bedGraphToBigWig) +- Alignment QC metrics (Preseq, picard) +- ChIP-seq QC metrics (deepTools, phantompeakqualtools) +- Call and annotate broad/narrow peaks (MACS2, HOMER) +- Create consensus set of peaks per antibody (BEDTools) +- Quantification and differential binding analysis (featureCounts, DESeq2) +- Collate appropriate files for genome browser visualisation (IGV) +- Collate and present various QC metrics (MultiQC, R) diff --git a/CITATIONS.md b/CITATIONS.md index bb15845ba..f432375d4 100644 --- a/CITATIONS.md +++ b/CITATIONS.md @@ -10,93 +10,117 @@ ## Pipeline tools -* [BWA](https://www.ncbi.nlm.nih.gov/pubmed/19451168/) - > Li H, Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 2009 Jul 15;25(14):1754-60. doi: 10.1093/bioinformatics/btp324. Epub 2009 May 18. PubMed PMID: 19451168; PubMed Central PMCID: PMC2705234. +- [BWA](https://www.ncbi.nlm.nih.gov/pubmed/19451168/) -* [BEDTools](https://www.ncbi.nlm.nih.gov/pubmed/20110278/) - > Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010 Mar 15;26(6):841-2. doi: 10.1093/bioinformatics/btq033. Epub 2010 Jan 28. PubMed PMID: 20110278; PubMed Central PMCID: PMC2832824. + > Li H, Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 2009 Jul 15;25(14):1754-60. doi: 10.1093/bioinformatics/btp324. Epub 2009 May 18. PubMed PMID: 19451168; PubMed Central PMCID: PMC2705234. -* [BamTools](https://www.ncbi.nlm.nih.gov/pubmed/21493652/) - > Barnett DW, Garrison EK, Quinlan AR, Strömberg MP, Marth GT. BamTools: a C++ API and toolkit for analyzing and managing BAM files. Bioinformatics. 2011 Jun 15;27(12):1691-2. doi: 10.1093/bioinformatics/btr174. Epub 2011 Apr 14. PubMed PMID: 21493652; PubMed Central PMCID: PMC3106182. +- [BEDTools](https://www.ncbi.nlm.nih.gov/pubmed/20110278/) -* [Bowtie2](https:/dx.doi.org/10.1038/nmeth.1923) - > Langmead, B. and Salzberg, S. L. 2012 Fast gapped-read alignment with Bowtie 2. Nature methods, 9(4), p. 357–359. doi: 10.1038/nmeth.1923. + > Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010 Mar 15;26(6):841-2. doi: 10.1093/bioinformatics/btq033. Epub 2010 Jan 28. PubMed PMID: 20110278; PubMed Central PMCID: PMC2832824. -* [deepTools](https://www.ncbi.nlm.nih.gov/pubmed/27079975/) - > Ramírez F, Ryan DP, Grüning B, Bhardwaj V, Kilpert F, Richter AS, Heyne S, Dündar F, Manke T. deepTools2: a next generation web server for deep-sequencing data analysis. Nucleic Acids Res. 2016 Jul 8;44(W1):W160-5. doi: 10.1093/nar/gkw257. Epub 2016 Apr 13. PubMed PMID: 27079975; PubMed Central PMCID: PMC4987876. +- [BamTools](https://www.ncbi.nlm.nih.gov/pubmed/21493652/) -* [FastQC](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/) + > Barnett DW, Garrison EK, Quinlan AR, Strömberg MP, Marth GT. BamTools: a C++ API and toolkit for analyzing and managing BAM files. Bioinformatics. 2011 Jun 15;27(12):1691-2. doi: 10.1093/bioinformatics/btr174. Epub 2011 Apr 14. PubMed PMID: 21493652; PubMed Central PMCID: PMC3106182. -* [featureCounts](https://www.ncbi.nlm.nih.gov/pubmed/24227677/) - > Liao Y, Smyth GK, Shi W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014 Apr 1;30(7):923-30. doi: 10.1093/bioinformatics/btt656. Epub 2013 Nov 13. PubMed PMID: 24227677. +- [Bowtie2](https:/dx.doi.org/10.1038/nmeth.1923) -* [HOMER](https://www.ncbi.nlm.nih.gov/pubmed/20513432/) - > Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010 May 28;38(4):576-89. doi: 10.1016/j.molcel.2010.05.004. PubMed PMID: 20513432; PubMed Central PMCID: PMC2898526. + > Langmead, B. and Salzberg, S. L. 2012 Fast gapped-read alignment with Bowtie 2. Nature methods, 9(4), p. 357–359. doi: 10.1038/nmeth.1923. -* [MACS2](https://www.ncbi.nlm.nih.gov/pubmed/18798982/) - > Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W, Liu XS. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008;9(9):R137. doi: 10.1186/gb-2008-9-9-r137. Epub 2008 Sep 17. PubMed PMID: 18798982; PubMed Central PMCID: PMC2592715. +- [deepTools](https://www.ncbi.nlm.nih.gov/pubmed/27079975/) -* [MultiQC](https://pubmed.ncbi.nlm.nih.gov/27312411/) - > Ewels P, Magnusson M, Lundin S, Käller M. MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics. 2016 Oct 1;32(19):3047-8. doi: 10.1093/bioinformatics/btw354. Epub 2016 Jun 16. PubMed PMID: 27312411; PubMed Central PMCID: PMC5039924. + > Ramírez F, Ryan DP, Grüning B, Bhardwaj V, Kilpert F, Richter AS, Heyne S, Dündar F, Manke T. deepTools2: a next generation web server for deep-sequencing data analysis. Nucleic Acids Res. 2016 Jul 8;44(W1):W160-5. doi: 10.1093/nar/gkw257. Epub 2016 Apr 13. PubMed PMID: 27079975; PubMed Central PMCID: PMC4987876. -* [phantompeakqualtools](https://www.ncbi.nlm.nih.gov/pubmed/22955991/) - > Landt SG, Marinov GK, Kundaje A, Kheradpour P, Pauli F, Batzoglou S, Bernstein BE, Bickel P, Brown JB, Cayting P, Chen Y, DeSalvo G, Epstein C, Fisher-Aylor KI, Euskirchen G, Gerstein M, Gertz J, Hartemink AJ, Hoffman MM, Iyer VR, Jung YL, Karmakar S, Kellis M, Kharchenko PV, Li Q, Liu T, Liu XS, Ma L, Milosavljevic A, Myers RM, Park PJ, Pazin MJ, Perry MD, Raha D, Reddy TE, Rozowsky J, Shoresh N, Sidow A, Slattery M, Stamatoyannopoulos JA, Tolstorukov MY, White KP, Xi S, Farnham PJ, Lieb JD, Wold BJ, Snyder M. ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res. 2012 Sep;22(9):1813-31. doi: 10.1101/gr.136184.111. PubMed PMID: 22955991; PubMed Central PMCID: PMC3431496. +- [FastQC](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/) -* [picard-tools](http://broadinstitute.github.io/picard) +- [featureCounts](https://www.ncbi.nlm.nih.gov/pubmed/24227677/) -* [preseq](https://www.ncbi.nlm.nih.gov/pubmed/23435259/) - > Daley T, Smith AD. Predicting the molecular complexity of sequencing libraries. Nat Methods. 2013 Apr;10(4):325-7. doi: 10.1038/nmeth.2375. Epub 2013 Feb 24. PubMed PMID: 23435259; PubMed Central PMCID: PMC3612374. + > Liao Y, Smyth GK, Shi W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014 Apr 1;30(7):923-30. doi: 10.1093/bioinformatics/btt656. Epub 2013 Nov 13. PubMed PMID: 24227677. -* [pysam](https://github.com/pysam-developers/pysam) +- [HOMER](https://www.ncbi.nlm.nih.gov/pubmed/20513432/) -* [SAMtools](https://www.ncbi.nlm.nih.gov/pubmed/19505943/) - > Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R; 1000 Genome Project Data Processing Subgroup. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 2009 Aug 15;25(16):2078-9. doi: 10.1093/bioinformatics/btp352. Epub 2009 Jun 8. PubMed PMID: 19505943; PubMed Central PMCID: PMC2723002. + > Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010 May 28;38(4):576-89. doi: 10.1016/j.molcel.2010.05.004. PubMed PMID: 20513432; PubMed Central PMCID: PMC2898526. -* [STAR](https://pubmed.ncbi.nlm.nih.gov/23104886/) - > Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR. STAR: ultrafast universal RNA-seq aligner Bioinformatics. 2013 Jan 1;29(1):15-21. doi: 10.1093/bioinformatics/bts635. Epub 2012 Oct 25. PubMed PMID: 23104886; PubMed Central PMCID: PMC3530905. +- [MACS2](https://www.ncbi.nlm.nih.gov/pubmed/18798982/) -* [Trim Galore!](https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/) + > Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W, Liu XS. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008;9(9):R137. doi: 10.1186/gb-2008-9-9-r137. Epub 2008 Sep 17. PubMed PMID: 18798982; PubMed Central PMCID: PMC2592715. -* [UCSC tools](https://www.ncbi.nlm.nih.gov/pubmed/20639541/) - > Kent WJ, Zweig AS, Barber G, Hinrichs AS, Karolchik D. BigWig and BigBed: enabling browsing of large distributed datasets. Bioinformatics. 2010 Sep 1;26(17):2204-7. doi: 10.1093/bioinformatics/btq351. Epub 2010 Jul 17. PubMed PMID: 20639541; PubMed Central PMCID: PMC2922891. +- [MultiQC](https://pubmed.ncbi.nlm.nih.gov/27312411/) + + > Ewels P, Magnusson M, Lundin S, Käller M. MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics. 2016 Oct 1;32(19):3047-8. doi: 10.1093/bioinformatics/btw354. Epub 2016 Jun 16. PubMed PMID: 27312411; PubMed Central PMCID: PMC5039924. + +- [phantompeakqualtools](https://www.ncbi.nlm.nih.gov/pubmed/22955991/) + + > Landt SG, Marinov GK, Kundaje A, Kheradpour P, Pauli F, Batzoglou S, Bernstein BE, Bickel P, Brown JB, Cayting P, Chen Y, DeSalvo G, Epstein C, Fisher-Aylor KI, Euskirchen G, Gerstein M, Gertz J, Hartemink AJ, Hoffman MM, Iyer VR, Jung YL, Karmakar S, Kellis M, Kharchenko PV, Li Q, Liu T, Liu XS, Ma L, Milosavljevic A, Myers RM, Park PJ, Pazin MJ, Perry MD, Raha D, Reddy TE, Rozowsky J, Shoresh N, Sidow A, Slattery M, Stamatoyannopoulos JA, Tolstorukov MY, White KP, Xi S, Farnham PJ, Lieb JD, Wold BJ, Snyder M. ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res. 2012 Sep;22(9):1813-31. doi: 10.1101/gr.136184.111. PubMed PMID: 22955991; PubMed Central PMCID: PMC3431496. + +- [picard-tools](http://broadinstitute.github.io/picard) + +- [preseq](https://www.ncbi.nlm.nih.gov/pubmed/23435259/) + + > Daley T, Smith AD. Predicting the molecular complexity of sequencing libraries. Nat Methods. 2013 Apr;10(4):325-7. doi: 10.1038/nmeth.2375. Epub 2013 Feb 24. PubMed PMID: 23435259; PubMed Central PMCID: PMC3612374. + +- [pysam](https://github.com/pysam-developers/pysam) + +- [SAMtools](https://www.ncbi.nlm.nih.gov/pubmed/19505943/) + + > Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R; 1000 Genome Project Data Processing Subgroup. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 2009 Aug 15;25(16):2078-9. doi: 10.1093/bioinformatics/btp352. Epub 2009 Jun 8. PubMed PMID: 19505943; PubMed Central PMCID: PMC2723002. + +- [STAR](https://pubmed.ncbi.nlm.nih.gov/23104886/) + + > Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR. STAR: ultrafast universal RNA-seq aligner Bioinformatics. 2013 Jan 1;29(1):15-21. doi: 10.1093/bioinformatics/bts635. Epub 2012 Oct 25. PubMed PMID: 23104886; PubMed Central PMCID: PMC3530905. + +- [Trim Galore!](https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/) + +- [UCSC tools](https://www.ncbi.nlm.nih.gov/pubmed/20639541/) + > Kent WJ, Zweig AS, Barber G, Hinrichs AS, Karolchik D. BigWig and BigBed: enabling browsing of large distributed datasets. Bioinformatics. 2010 Sep 1;26(17):2204-7. doi: 10.1093/bioinformatics/btq351. Epub 2010 Jul 17. PubMed PMID: 20639541; PubMed Central PMCID: PMC2922891. ## R packages -* [R](https://www.R-project.org/) - > R Core Team (2017). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. +- [R](https://www.R-project.org/) + + > R Core Team (2017). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. + +- [DESeq2](https://www.ncbi.nlm.nih.gov/pubmed/25516281/) + + > Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550. PubMed PMID: 25516281; PubMed Central PMCID: PMC4302049. + +- [vsn](https://bioconductor.org/packages/release/bioc/html/vsn.html) + + > Wolfgang Huber, Anja von Heydebreck, Holger Sueltmann, Annemarie Poustka and Martin Vingron. Variance Stabilization Applied to Microarray Data Calibration and to the Quantification of Differential Expression. Bioinformatics 18, S96-S104 (2002). + +- [UpSetR](https://CRAN.R-project.org/package=UpSetR) + + > Nils Gehlenborg (2017). UpSetR: A More Scalable Alternative to Venn and Euler Diagrams for Visualizing Intersecting Sets. + +- [ggplot2](https://cran.r-project.org/web/packages/ggplot2/index.html) + + > H. Wickham. ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag New York, 2016. + +- [reshape2](http://www.jstatsoft.org/v21/i12/) + + > Hadley Wickham (2007). Reshaping Data with the reshape Package. Journal of Statistical Software, 21(12), 1-20. -* [DESeq2](https://www.ncbi.nlm.nih.gov/pubmed/25516281/) - > Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550. PubMed PMID: 25516281; PubMed Central PMCID: PMC4302049. +- [scales](https://CRAN.R-project.org/package=scales) -* [vsn](https://bioconductor.org/packages/release/bioc/html/vsn.html) - > Wolfgang Huber, Anja von Heydebreck, Holger Sueltmann, Annemarie Poustka and Martin Vingron. Variance Stabilization Applied to Microarray Data Calibration and to the Quantification of Differential Expression. Bioinformatics 18, S96-S104 (2002). + > Hadley Wickham (2018). scales: Scale Functions for Visualization. -* [UpSetR](https://CRAN.R-project.org/package=UpSetR) - > Nils Gehlenborg (2017). UpSetR: A More Scalable Alternative to Venn and Euler Diagrams for Visualizing Intersecting Sets. +- [pheatmap](https://CRAN.R-project.org/package=pheatmap) -* [ggplot2](https://cran.r-project.org/web/packages/ggplot2/index.html) - > H. Wickham. ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag New York, 2016. + > Raivo Kolde (2018). pheatmap: Pretty Heatmaps. -* [reshape2](http://www.jstatsoft.org/v21/i12/) - > Hadley Wickham (2007). Reshaping Data with the reshape Package. Journal of Statistical Software, 21(12), 1-20. +- [lattice](https://cran.r-project.org/web/packages/lattice/index.html) -* [scales](https://CRAN.R-project.org/package=scales) - > Hadley Wickham (2018). scales: Scale Functions for Visualization. + > Sarkar, Deepayan (2008) Lattice: Multivariate Data Visualization with R. Springer, New York. ISBN 978-0-387-75968-5. -* [pheatmap](https://CRAN.R-project.org/package=pheatmap) - > Raivo Kolde (2018). pheatmap: Pretty Heatmaps. +- [RColorBrewer](https://CRAN.R-project.org/package=RColorBrewer) -* [lattice](https://cran.r-project.org/web/packages/lattice/index.html) - > Sarkar, Deepayan (2008) Lattice: Multivariate Data Visualization with R. Springer, New York. ISBN 978-0-387-75968-5. + > Erich Neuwirth (2014). RColorBrewer: ColorBrewer Palettes. -* [RColorBrewer](https://CRAN.R-project.org/package=RColorBrewer) - > Erich Neuwirth (2014). RColorBrewer: ColorBrewer Palettes. +- [optparse](https://CRAN.R-project.org/package=optparse) -* [optparse](https://CRAN.R-project.org/package=optparse) - > Trevor L Davis (2018). optparse: Command Line Option Parser. + > Trevor L Davis (2018). optparse: Command Line Option Parser. -* [xfun](https://CRAN.R-project.org/package=xfun) - > Yihui Xie (2018). xfun: Miscellaneous Functions by 'Yihui Xie'. +- [xfun](https://CRAN.R-project.org/package=xfun) + > Yihui Xie (2018). xfun: Miscellaneous Functions by 'Yihui Xie'. ## Software packaging/containerisation tools diff --git a/README.md b/README.md index 9888720e0..9a8b2d263 100644 --- a/README.md +++ b/README.md @@ -29,28 +29,28 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool 3. Alignment ([`BWA`](https://sourceforge.net/projects/bio-bwa/files/)) 4. Mark duplicates ([`picard`](https://broadinstitute.github.io/picard/)) 5. Merge alignments from multiple libraries of the same sample ([`picard`](https://broadinstitute.github.io/picard/)) - 1. Re-mark duplicates ([`picard`](https://broadinstitute.github.io/picard/)) - 2. Filtering to remove: - * reads mapping to blacklisted regions ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/), [`BEDTools`](https://github.com/arq5x/bedtools2/)) - * reads that are marked as duplicates ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) - * reads that arent marked as primary alignments ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) - * reads that are unmapped ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) - * reads that map to multiple locations ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) - * reads containing > 4 mismatches ([`BAMTools`](https://github.com/pezmaster31/bamtools)) - * reads that have an insert size > 2kb ([`BAMTools`](https://github.com/pezmaster31/bamtools); _paired-end only_) - * reads that map to different chromosomes ([`Pysam`](http://pysam.readthedocs.io/en/latest/installation.html); _paired-end only_) - * reads that arent in FR orientation ([`Pysam`](http://pysam.readthedocs.io/en/latest/installation.html); _paired-end only_) - * reads where only one read of the pair fails the above criteria ([`Pysam`](http://pysam.readthedocs.io/en/latest/installation.html); _paired-end only_) - 3. Alignment-level QC and estimation of library complexity ([`picard`](https://broadinstitute.github.io/picard/), [`Preseq`](http://smithlabresearch.org/software/preseq/)) - 4. Create normalised bigWig files scaled to 1 million mapped reads ([`BEDTools`](https://github.com/arq5x/bedtools2/), [`bedGraphToBigWig`](http://hgdownload.soe.ucsc.edu/admin/exe/)) - 5. Generate gene-body meta-profile from bigWig files ([`deepTools`](https://deeptools.readthedocs.io/en/develop/content/tools/plotProfile.html)) - 6. Calculate genome-wide IP enrichment relative to control ([`deepTools`](https://deeptools.readthedocs.io/en/develop/content/tools/plotFingerprint.html)) - 7. Calculate strand cross-correlation peak and ChIP-seq quality measures including NSC and RSC ([`phantompeakqualtools`](https://github.com/kundajelab/phantompeakqualtools)) - 8. Call broad/narrow peaks ([`MACS2`](https://github.com/taoliu/MACS)) - 9. Annotate peaks relative to gene features ([`HOMER`](http://homer.ucsd.edu/homer/download.html)) - 10. Create consensus peakset across all samples and create tabular file to aid in the filtering of the data ([`BEDTools`](https://github.com/arq5x/bedtools2/)) - 11. Count reads in consensus peaks ([`featureCounts`](http://bioinf.wehi.edu.au/featureCounts/)) - 12. Differential binding analysis, PCA and clustering ([`R`](https://www.r-project.org/), [`DESeq2`](https://bioconductor.org/packages/release/bioc/html/DESeq2.html)) + 1. Re-mark duplicates ([`picard`](https://broadinstitute.github.io/picard/)) + 2. Filtering to remove: + - reads mapping to blacklisted regions ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/), [`BEDTools`](https://github.com/arq5x/bedtools2/)) + - reads that are marked as duplicates ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) + - reads that arent marked as primary alignments ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) + - reads that are unmapped ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) + - reads that map to multiple locations ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) + - reads containing > 4 mismatches ([`BAMTools`](https://github.com/pezmaster31/bamtools)) + - reads that have an insert size > 2kb ([`BAMTools`](https://github.com/pezmaster31/bamtools); _paired-end only_) + - reads that map to different chromosomes ([`Pysam`](http://pysam.readthedocs.io/en/latest/installation.html); _paired-end only_) + - reads that arent in FR orientation ([`Pysam`](http://pysam.readthedocs.io/en/latest/installation.html); _paired-end only_) + - reads where only one read of the pair fails the above criteria ([`Pysam`](http://pysam.readthedocs.io/en/latest/installation.html); _paired-end only_) + 3. Alignment-level QC and estimation of library complexity ([`picard`](https://broadinstitute.github.io/picard/), [`Preseq`](http://smithlabresearch.org/software/preseq/)) + 4. Create normalised bigWig files scaled to 1 million mapped reads ([`BEDTools`](https://github.com/arq5x/bedtools2/), [`bedGraphToBigWig`](http://hgdownload.soe.ucsc.edu/admin/exe/)) + 5. Generate gene-body meta-profile from bigWig files ([`deepTools`](https://deeptools.readthedocs.io/en/develop/content/tools/plotProfile.html)) + 6. Calculate genome-wide IP enrichment relative to control ([`deepTools`](https://deeptools.readthedocs.io/en/develop/content/tools/plotFingerprint.html)) + 7. Calculate strand cross-correlation peak and ChIP-seq quality measures including NSC and RSC ([`phantompeakqualtools`](https://github.com/kundajelab/phantompeakqualtools)) + 8. Call broad/narrow peaks ([`MACS2`](https://github.com/taoliu/MACS)) + 9. Annotate peaks relative to gene features ([`HOMER`](http://homer.ucsd.edu/homer/download.html)) + 10. Create consensus peakset across all samples and create tabular file to aid in the filtering of the data ([`BEDTools`](https://github.com/arq5x/bedtools2/)) + 11. Count reads in consensus peaks ([`featureCounts`](http://bioinf.wehi.edu.au/featureCounts/)) + 12. Differential binding analysis, PCA and clustering ([`R`](https://www.r-project.org/), [`DESeq2`](https://bioconductor.org/packages/release/bioc/html/DESeq2.html)) 6. Create IGV session file containing bigWig tracks, peaks and differential sites for data visualisation ([`IGV`](https://software.broadinstitute.org/software/igv/)). 7. Present QC for raw read, alignment, peak-calling and differential binding results ([`MultiQC`](http://multiqc.info/), [`R`](https://www.r-project.org/)) diff --git a/assets/bamtools_filter_pe.json b/assets/bamtools_filter_pe.json index b69b41ba5..618b7e9c3 100755 --- a/assets/bamtools_filter_pe.json +++ b/assets/bamtools_filter_pe.json @@ -1,18 +1,11 @@ { - "filters" : [ - { "id" : "insert_min", - "insertSize" : ">=-2000" - }, + "filters": [ + { "id": "insert_min", "insertSize": ">=-2000" }, - { "id" : "insert_max", - "insertSize" : "<=2000" - }, + { "id": "insert_max", "insertSize": "<=2000" }, - { "id" : "mismatch", - "tag" : "NM:<=4" - } + { "id": "mismatch", "tag": "NM:<=4" } ], - "rule" : " insert_min & insert_max & mismatch " - + "rule": " insert_min & insert_max & mismatch " } diff --git a/assets/bamtools_filter_se.json b/assets/bamtools_filter_se.json index f62800e7f..8928ab1cd 100755 --- a/assets/bamtools_filter_se.json +++ b/assets/bamtools_filter_se.json @@ -1,10 +1,5 @@ { - "filters" : [ - { "id" : "mismatch", - "tag" : "NM:<=4" - } - ], - - "rule" : " mismatch " + "filters": [{ "id": "mismatch", "tag": "NM:<=4" }], + "rule": " mismatch " } diff --git a/assets/multiqc_config.yml b/assets/multiqc_config.yml index f9f280673..ad69b5d8a 100644 --- a/assets/multiqc_config.yml +++ b/assets/multiqc_config.yml @@ -1,161 +1,161 @@ report_comment: > - This report has been generated by the nf-core/chipseq - analysis pipeline. For information about how to interpret these results, please see the - documentation. + This report has been generated by the nf-core/chipseq + analysis pipeline. For information about how to interpret these results, please see the + documentation. -data_format: 'yaml' +data_format: "yaml" export_plots: true run_modules: - - custom_content - - fastqc - - cutadapt - - samtools - - picard - - preseq - - featureCounts - - deeptools - - phantompeakqualtools + - custom_content + - fastqc + - cutadapt + - samtools + - picard + - preseq + - featureCounts + - deeptools + - phantompeakqualtools exclude_modules: - - 'general_stats' + - "general_stats" module_order: - - fastqc: - name: 'LIB: FastQC (raw)' - info: 'This section of the report shows FastQC results before adapter trimming for individual libraries.' - path_filters: - - './fastqc/*.zip' - - cutadapt: - name: 'LIB: cutadapt (trimmed)' - info: 'This section of the report shows the length of trimmed reads by cutadapt for individual libraries.' - - fastqc: - name: 'LIB: FastQC (trimmed)' - info: 'This section of the report shows FastQC results after adapter trimming for individual libraries.' - path_filters: - - './trimgalore/fastqc/*.zip' - - samtools: - name: 'LIB: SAMTools' - info: 'This section of the report shows SAMTools results for individual libraries.' - path_filters: - - './alignment/library/*' - - samtools: - name: 'MERGED LIB: SAMTools (unfiltered)' - info: 'This section of the report shows SAMTools results after merging libraries and before filtering.' - path_filters: - - './alignment/mergedLibrary/unfiltered/*.mLb.mkD.sorted.bam*' - - picard: - name: 'MERGED LIB: Picard (unfiltered)' - info: 'This section of the report shows picard results after merging libraries and before filtering.' - path_filters: - - './alignment/mergedLibrary/unfiltered/picard_metrics/*' - - preseq: - name: 'MERGED LIB: Preseq (unfiltered)' - info: 'This section of the report shows Preseq results after merging libraries and before filtering.' - - samtools: - name: 'MERGED LIB: SAMTools (filtered)' - info: 'This section of the report shows SAMTools results after merging libraries and after filtering.' - path_filters: - - './alignment/mergedLibrary/filtered/*.mLb.clN.sorted.bam*' - - picard: - name: 'MERGED LIB: Picard (filtered)' - info: 'This section of the report shows picard results after merging libraries and after filtering.' - path_filters: - - './alignment/mergedLibrary/filtered/picard_metrics/*' - - deeptools: - name: 'MERGED LIB: deepTools' - anchor: 'mlib_deeptools' - info: 'This section of the report shows ChIP-seq QC plots generated by deepTools.' - - featureCounts: - name: 'MERGED LIB: featureCounts' - anchor: 'mlib_featurecounts' - info: 'This section of the report shows featureCounts results for the number of reads assigned to merged library consensus peaks.' - path_filters: - - './macs/consensus/*.summary' + - fastqc: + name: "LIB: FastQC (raw)" + info: "This section of the report shows FastQC results before adapter trimming for individual libraries." + path_filters: + - "./fastqc/*.zip" + - cutadapt: + name: "LIB: cutadapt (trimmed)" + info: "This section of the report shows the length of trimmed reads by cutadapt for individual libraries." + - fastqc: + name: "LIB: FastQC (trimmed)" + info: "This section of the report shows FastQC results after adapter trimming for individual libraries." + path_filters: + - "./trimgalore/fastqc/*.zip" + - samtools: + name: "LIB: SAMTools" + info: "This section of the report shows SAMTools results for individual libraries." + path_filters: + - "./alignment/library/*" + - samtools: + name: "MERGED LIB: SAMTools (unfiltered)" + info: "This section of the report shows SAMTools results after merging libraries and before filtering." + path_filters: + - "./alignment/mergedLibrary/unfiltered/*.mLb.mkD.sorted.bam*" + - picard: + name: "MERGED LIB: Picard (unfiltered)" + info: "This section of the report shows picard results after merging libraries and before filtering." + path_filters: + - "./alignment/mergedLibrary/unfiltered/picard_metrics/*" + - preseq: + name: "MERGED LIB: Preseq (unfiltered)" + info: "This section of the report shows Preseq results after merging libraries and before filtering." + - samtools: + name: "MERGED LIB: SAMTools (filtered)" + info: "This section of the report shows SAMTools results after merging libraries and after filtering." + path_filters: + - "./alignment/mergedLibrary/filtered/*.mLb.clN.sorted.bam*" + - picard: + name: "MERGED LIB: Picard (filtered)" + info: "This section of the report shows picard results after merging libraries and after filtering." + path_filters: + - "./alignment/mergedLibrary/filtered/picard_metrics/*" + - deeptools: + name: "MERGED LIB: deepTools" + anchor: "mlib_deeptools" + info: "This section of the report shows ChIP-seq QC plots generated by deepTools." + - featureCounts: + name: "MERGED LIB: featureCounts" + anchor: "mlib_featurecounts" + info: "This section of the report shows featureCounts results for the number of reads assigned to merged library consensus peaks." + path_filters: + - "./macs/consensus/*.summary" report_section_order: - peak_count: - before: mlib_deeptools - frip_score: - before: peak_count - peak_annotation: - before: frip_score - strand_shift_correlation: - before: peak_annotation - nsc_coefficient: - before: strand_shift_correlation - rsc_coefficient: - before: nsc_coefficient - mlib_featurecounts: - before: rsc_coefficient - deseq2_pca_1: - order: -1600 - deseq2_pca_2: - order: -1700 - deseq2_pca_3: - order: -1800 - deseq2_pca_4: - order: -1900 - deseq2_pca_5: - order: -2000 - deseq2_pca_6: - order: -2100 - deseq2_pca_7: - order: -2200 - deseq2_pca_8: - order: -2300 - deseq2_pca_9: - order: -2400 - deseq2_pca_10: - order: -2500 - deseq2_clustering_1: - order: -2600 - deseq2_clustering_2: - order: -2700 - deseq2_clustering_3: - order: -2800 - deseq2_clustering_4: - order: -2900 - deseq2_clustering_5: - order: -3000 - deseq2_clustering_6: - order: -3100 - deseq2_clustering_7: - order: -3200 - deseq2_clustering_8: - order: -3300 - deseq2_clustering_9: - order: -3400 - deseq2_clustering_10: - order: -3500 - software_versions: - order: -3600 - nf-core-chipseq-summary: - order: -3700 + peak_count: + before: mlib_deeptools + frip_score: + before: peak_count + peak_annotation: + before: frip_score + strand_shift_correlation: + before: peak_annotation + nsc_coefficient: + before: strand_shift_correlation + rsc_coefficient: + before: nsc_coefficient + mlib_featurecounts: + before: rsc_coefficient + deseq2_pca_1: + order: -1600 + deseq2_pca_2: + order: -1700 + deseq2_pca_3: + order: -1800 + deseq2_pca_4: + order: -1900 + deseq2_pca_5: + order: -2000 + deseq2_pca_6: + order: -2100 + deseq2_pca_7: + order: -2200 + deseq2_pca_8: + order: -2300 + deseq2_pca_9: + order: -2400 + deseq2_pca_10: + order: -2500 + deseq2_clustering_1: + order: -2600 + deseq2_clustering_2: + order: -2700 + deseq2_clustering_3: + order: -2800 + deseq2_clustering_4: + order: -2900 + deseq2_clustering_5: + order: -3000 + deseq2_clustering_6: + order: -3100 + deseq2_clustering_7: + order: -3200 + deseq2_clustering_8: + order: -3300 + deseq2_clustering_9: + order: -3400 + deseq2_clustering_10: + order: -3500 + software_versions: + order: -3600 + nf-core-chipseq-summary: + order: -3700 custom_plot_config: - picard_insert_size: - cpswitch_c_active: False - smooth_points: 1000 - featurecounts: - cpswitch_c_active: False + picard_insert_size: + cpswitch_c_active: False + smooth_points: 1000 + featurecounts: + cpswitch_c_active: False extra_fn_clean_exts: - - 'fastq.gz' - - '_trimmed' - - '_val' - - 'sorted.bam' - - '.Lb' - - 'mkD' - - 'clN' - - 'mLb' - - '_peaks' - - '.FRiP' - - '.peak' - - '_spp' - - '.spp' - - 'ccurve' + - "fastq.gz" + - "_trimmed" + - "_val" + - "sorted.bam" + - ".Lb" + - "mkD" + - "clN" + - "mLb" + - "_peaks" + - ".FRiP" + - ".peak" + - "_spp" + - ".spp" + - "ccurve" # # Customise the module search patterns to speed up execution time # # - Skip module sub-tools that we are not interested in @@ -163,13 +163,13 @@ extra_fn_clean_exts: # # - Don't add anything that is the same as the MultiQC default # # See https://multiqc.info/docs/#optimise-file-search-patterns for details sp: - cutadapt: - fn: '*trimming_report.txt' - preseq: - fn: '*.ccurve.txt' - deeptools/plotFingerprintOutRawCounts: - fn: '*plotFingerprint*' - deeptools/plotProfile: - fn: '*plotProfile*' - phantompeakqualtools/out: - fn: '*.spp.out' + cutadapt: + fn: "*trimming_report.txt" + preseq: + fn: "*.ccurve.txt" + deeptools/plotFingerprintOutRawCounts: + fn: "*plotFingerprint*" + deeptools/plotProfile: + fn: "*plotProfile*" + phantompeakqualtools/out: + fn: "*.spp.out" diff --git a/docs/output.md b/docs/output.md index d115a7a9f..88b9b99bf 100644 --- a/docs/output.md +++ b/docs/output.md @@ -21,10 +21,10 @@ The initial QC and alignments are performed at the library-level e.g. if the sam
Output files -* `fastqc/` - * `*_fastqc.html`: FastQC report containing quality metrics for read 1 (*and read2 if paired-end*) **before** adapter trimming. -* `fastqc/zips/` - * `*_fastqc.zip`: Zip archive containing the FastQC report, tab-delimited data file and plot images. +- `fastqc/` + - `*_fastqc.html`: FastQC report containing quality metrics for read 1 (_and read2 if paired-end_) **before** adapter trimming. +- `fastqc/zips/` + - `*_fastqc.zip`: Zip archive containing the FastQC report, tab-delimited data file and plot images.
@@ -35,14 +35,14 @@ The initial QC and alignments are performed at the library-level e.g. if the sam
Output files -* `trim_galore/` - * `*fastq.gz`: If `--save_trimmed` is specified, FastQ files **after** adapter trimming will be placed in this directory. -* `trim_galore/logs/` - * `*.log`: Log file generated by Trim Galore!. -* `trim_galore/fastqc/` - * `*_fastqc.html`: FastQC report containing quality metrics for read 1 (*and read2 if paired-end*) **after** adapter trimming. -* `trim_galore/fastqc/zips/` - * `*_fastqc.zip`: Zip archive containing the FastQC report, tab-delimited data file and plot images. +- `trim_galore/` + - `*fastq.gz`: If `--save_trimmed` is specified, FastQ files **after** adapter trimming will be placed in this directory. +- `trim_galore/logs/` + - `*.log`: Log file generated by Trim Galore!. +- `trim_galore/fastqc/` + - `*_fastqc.html`: FastQC report containing quality metrics for read 1 (_and read2 if paired-end_) **after** adapter trimming. +- `trim_galore/fastqc/zips/` + - `*_fastqc.zip`: Zip archive containing the FastQC report, tab-delimited data file and plot images.
@@ -55,10 +55,10 @@ The initial QC and alignments are performed at the library-level e.g. if the sam
Output files -* `bwa/library/` - * `*.bam`: The files resulting from the alignment of individual libraries are not saved by default so this directory will not be present in your results. You can override this behaviour with the use of the `--save_align_intermeds` flag in which case it will contain the coordinate sorted alignment files in [`*.bam`](https://samtools.github.io/hts-specs/SAMv1.pdf) format. -* `bwa/library/samtools_stats/` - * SAMtools `.sorted.bam.flagstat`, `.sorted.bam.idxstats` and `.sorted.bam.stats` files generated from the alignment files. +- `bwa/library/` + - `*.bam`: The files resulting from the alignment of individual libraries are not saved by default so this directory will not be present in your results. You can override this behaviour with the use of the `--save_align_intermeds` flag in which case it will contain the coordinate sorted alignment files in [`*.bam`](https://samtools.github.io/hts-specs/SAMv1.pdf) format. +- `bwa/library/samtools_stats/` + - SAMtools `.sorted.bam.flagstat`, `.sorted.bam.idxstats` and `.sorted.bam.stats` files generated from the alignment files. > **NB:** File names in the resulting directory (i.e. `bwa/library/`) will have the '`.Lb.`' suffix. @@ -77,17 +77,17 @@ The library-level alignments associated with the same sample are merged and subs
Output files -* `bwa/mergedLibrary/` - * `*.bam`: Merged library-level, coordinate sorted `*.bam` files after the marking of duplicates, and filtering based on various criteria. The file suffix for the final filtered files will be `*.mLb.clN.*`. If you specify the `--save_align_intermeds` parameter then two additional sets of files will be present. These represent the unfiltered alignments with duplicates marked (`*.mLb.mkD.*`), and in the case of paired-end datasets the filtered alignments before the removal of orphan read pairs (`*.mLb.flT.*`). -* `bwa/mergedLibrary/samtools_stats/` - * SAMtools `*.flagstat`, `*.idxstats` and `*.stats` files generated from the alignment files. -* `bwa/mergedLibrary/picard_metrics/` - * `*_metrics`: Alignment QC files from picard CollectMultipleMetrics. - * `*.metrics.txt`: Metrics file from MarkDuplicates. -* `bwa/mergedLibrary/picard_metrics/pdf/` - * `*.pdf`: Alignment QC plot files from picard CollectMultipleMetrics. -* `bwa/mergedLibrary/preseq/` - * `*.ccurve.txt`: Preseq expected future yield file. +- `bwa/mergedLibrary/` + - `*.bam`: Merged library-level, coordinate sorted `*.bam` files after the marking of duplicates, and filtering based on various criteria. The file suffix for the final filtered files will be `*.mLb.clN.*`. If you specify the `--save_align_intermeds` parameter then two additional sets of files will be present. These represent the unfiltered alignments with duplicates marked (`*.mLb.mkD.*`), and in the case of paired-end datasets the filtered alignments before the removal of orphan read pairs (`*.mLb.flT.*`). +- `bwa/mergedLibrary/samtools_stats/` + - SAMtools `*.flagstat`, `*.idxstats` and `*.stats` files generated from the alignment files. +- `bwa/mergedLibrary/picard_metrics/` + - `*_metrics`: Alignment QC files from picard CollectMultipleMetrics. + - `*.metrics.txt`: Metrics file from MarkDuplicates. +- `bwa/mergedLibrary/picard_metrics/pdf/` + - `*.pdf`: Alignment QC plot files from picard CollectMultipleMetrics. +- `bwa/mergedLibrary/preseq/` + - `*.ccurve.txt`: Preseq expected future yield file. > **NB:** File names in the resulting directory (i.e. `bwa/mergedLibrary/`) will have the '`.mLb.`' suffix. @@ -110,8 +110,8 @@ The [Preseq](http://smithlabresearch.org/software/preseq/) package is aimed at p
Output files -* `bwa/mergedLibrary/bigwig/` - * `*.bigWig`: Normalised bigWig files scaled to 1 million mapped reads. +- `bwa/mergedLibrary/bigwig/` + - `*.bigWig`: Normalised bigWig files scaled to 1 million mapped reads.
@@ -122,13 +122,13 @@ The [bigWig](https://genome.ucsc.edu/goldenpath/help/bigWig.html) format is in a
Output files -* `bwa/mergedLibrary/phantompeakqualtools/` - * `*.spp.out`, `*.spp.pdf`: phantompeakqualtools output files. - * `*_mqc.tsv`: MultiQC custom content files. -* `bwa/mergedLibrary/deepTools/plotFingerprint/` - * `*.plotFingerprint.pdf`, `*.plotFingerprint.qcmetrics.txt`, `*.plotFingerprint.raw.txt`: plotFingerprint output files. -* `bwa/mergedLibrary/deepTools/plotProfile/` - * `*.computeMatrix.mat.gz`, `*.computeMatrix.vals.mat.tab`, `*.plotProfile.pdf`, `*.plotProfile.tab`, `*.plotHeatmap.pdf`, `*.plotHeatmap.mat.tab`: plotProfile output files. +- `bwa/mergedLibrary/phantompeakqualtools/` + - `*.spp.out`, `*.spp.pdf`: phantompeakqualtools output files. + - `*_mqc.tsv`: MultiQC custom content files. +- `bwa/mergedLibrary/deepTools/plotFingerprint/` + - `*.plotFingerprint.pdf`, `*.plotFingerprint.qcmetrics.txt`, `*.plotFingerprint.raw.txt`: plotFingerprint output files. +- `bwa/mergedLibrary/deepTools/plotProfile/` + - `*.computeMatrix.mat.gz`, `*.computeMatrix.vals.mat.tab`, `*.plotProfile.pdf`, `*.plotProfile.tab`, `*.plotHeatmap.pdf`, `*.plotHeatmap.mat.tab`: plotProfile output files.
@@ -157,13 +157,13 @@ The results from deepTools plotProfile gives you a quick visualisation for the g
Output files -* `bwa/mergedLibrary/macs2//` - * `*.xls`, `*.broadPeak` or `*.narrowPeak`, `*.gappedPeak`, `*summits.bed`: MACS2 output files - the files generated will depend on whether MACS2 has been run in *narrowPeak* or *broadPeak* mode. - * `*.annotatePeaks.txt`: HOMER peak-to-gene annotation file. -* `bwa/mergedLibrary/macs2//qc/` - * `macs_peak.plots.pdf`: QC plots for MACS2 peaks. - * `macs_annotatePeaks.plots.pdf`: QC plots for peak-to-gene feature annotation. - * `*.FRiP_mqc.tsv`, `*.count_mqc.tsv`, `macs_annotatePeaks.summary_mqc.tsv`: MultiQC custom-content files for FRiP score, peak count and peak-to-gene ratios. +- `bwa/mergedLibrary/macs2//` + - `*.xls`, `*.broadPeak` or `*.narrowPeak`, `*.gappedPeak`, `*summits.bed`: MACS2 output files - the files generated will depend on whether MACS2 has been run in _narrowPeak_ or _broadPeak_ mode. + - `*.annotatePeaks.txt`: HOMER peak-to-gene annotation file. +- `bwa/mergedLibrary/macs2//qc/` + - `macs_peak.plots.pdf`: QC plots for MACS2 peaks. + - `macs_annotatePeaks.plots.pdf`: QC plots for peak-to-gene feature annotation. + - `*.FRiP_mqc.tsv`, `*.count_mqc.tsv`, `macs_annotatePeaks.summary_mqc.tsv`: MultiQC custom-content files for FRiP score, peak count and peak-to-gene ratios. > **NB:** `` in the directory structure above corresponds to the type of peak that you have specified to call with MACS2 i.e. `broadPeak` or `narrowPeak`. If you so wish, you can call both narrow and broad peaks without redoing the preceding steps in the pipeline such as the alignment and filtering. For example, if you already have broad peaks then just add `--narrow_peak -resume` to the command you used to run the pipeline, and these will be called too! However, resuming the pipeline will only be possible if you have not deleted the `work/` directory generated by the pipeline. @@ -173,7 +173,7 @@ The results from deepTools plotProfile gives you a quick visualisation for the g ![MultiQC - MACS2 total peak count plot](images/mqc_macs2_peak_count_plot.png) -[HOMER annotatePeaks.pl](http://homer.ucsd.edu/homer/ngs/annotation.html) is used to annotate the peaks relative to known genomic features. HOMER is able to use the `--gtf` annotation file which is provided to the pipeline. Please note that some of the output columns will be blank because the annotation is not provided using HOMER's in-built database format. However, the more important fields required for downstream analysis will be populated i.e. *Annotation*, *Distance to TSS* and *Nearest Promoter ID*. +[HOMER annotatePeaks.pl](http://homer.ucsd.edu/homer/ngs/annotation.html) is used to annotate the peaks relative to known genomic features. HOMER is able to use the `--gtf` annotation file which is provided to the pipeline. Please note that some of the output columns will be blank because the annotation is not provided using HOMER's in-built database format. However, the more important fields required for downstream analysis will be populated i.e. _Annotation_, _Distance to TSS_ and _Nearest Promoter ID_. ![MultiQC - HOMER annotatePeaks peak-to-gene feature ratio plot](images/mqc_annotatePeaks_feature_percentage_plot.png) @@ -186,20 +186,20 @@ Various QC plots per sample including number of peaks, fold-change distribution,
Output files -* `bwa/mergedLibrary/macs2//consensus/` - * `*.bed`: Consensus peak-set across all samples in BED format. - * `*.saf`: Consensus peak-set across all samples in SAF format. Required by featureCounts for read quantification. - * `*.featureCounts.txt`: Read counts across all samples relative to consensus peak-set. - * `*.annotatePeaks.txt`: HOMER peak-to-gene annotation file for consensus peaks. - * `*.boolean.annotatePeaks.txt`: Spreadsheet representation of consensus peak-set across samples **with** gene annotation columns. The columns from individual peak files are included in this file along with the ability to filter peaks based on their presence or absence in multiple replicates/conditions. - * `*.boolean.txt`: Spreadsheet representation of consensus peak-set across samples **without** gene annotation columns. Same as file above but without annotation columns. - * `*.boolean.intersect.plot.pdf`, `*.boolean.intersect.txt`: [UpSetR](https://cran.r-project.org/web/packages/UpSetR/README.html) files to illustrate peak intersection. +- `bwa/mergedLibrary/macs2//consensus/` + - `*.bed`: Consensus peak-set across all samples in BED format. + - `*.saf`: Consensus peak-set across all samples in SAF format. Required by featureCounts for read quantification. + - `*.featureCounts.txt`: Read counts across all samples relative to consensus peak-set. + - `*.annotatePeaks.txt`: HOMER peak-to-gene annotation file for consensus peaks. + - `*.boolean.annotatePeaks.txt`: Spreadsheet representation of consensus peak-set across samples **with** gene annotation columns. The columns from individual peak files are included in this file along with the ability to filter peaks based on their presence or absence in multiple replicates/conditions. + - `*.boolean.txt`: Spreadsheet representation of consensus peak-set across samples **without** gene annotation columns. Same as file above but without annotation columns. + - `*.boolean.intersect.plot.pdf`, `*.boolean.intersect.txt`: [UpSetR](https://cran.r-project.org/web/packages/UpSetR/README.html) files to illustrate peak intersection.
In order to perform the differential binding analysis we need to be able to carry out the read quantification for the same intervals across **all** of the samples in the experiment. To this end, the individual peak-sets called per sample have to be merged together in order to create a consensus set of peaks. -Using the consensus peaks it is possible to assess the degree of overlap between the peaks from a set of samples e.g. *Which consensus peaks contain peaks that are common/unique to a given set of samples?*. This may be useful for downstream filtering of peaks based on whether they are called in multiple replicates/conditions. Please note that it is possible for a consensus peak to contain multiple peaks from the same sample. Unfortunately, this is sample-dependent but the files generated by the pipeline do have columns that report such instances and allow you to factor them into any further analysis. +Using the consensus peaks it is possible to assess the degree of overlap between the peaks from a set of samples e.g. _Which consensus peaks contain peaks that are common/unique to a given set of samples?_. This may be useful for downstream filtering of peaks based on whether they are called in multiple replicates/conditions. Please note that it is possible for a consensus peak to contain multiple peaks from the same sample. Unfortunately, this is sample-dependent but the files generated by the pipeline do have columns that report such instances and allow you to factor them into any further analysis. ![R - UpSetR peak intersection plot](images/r_upsetr_intersect_plot.png) @@ -214,19 +214,19 @@ The [featureCounts](http://bioinf.wehi.edu.au/featureCounts/) tool is used to co
Output files -* `bwa/mergedLibrary/macs2//consensus//deseq2/` - * `*.results.txt`: Spreadsheet containing differential binding results across all consensus peaks and all comparisons. - * `*.plots.pdf`: File containing PCA and hierarchical clustering plots. - * `*.log`: Log file with information for number of differentially bound intervals at different FDR and fold-change thresholds for each comparison. - * `*.dds.rld.RData`: File containing R `dds` and `rld` objects generated by DESeq2. - * `R_sessionInfo.log`: File containing information about R, the OS and attached or loaded packages. - * `bwa/mergedLibrary/macs2//consensus///` - * `*.results.txt`: Spreadsheet containing comparison-specific DESeq2 output for differential binding results across all peaks. - * `*FDR0.01.results.txt`, `*FDR0.05.results.txt`: Subset of above file for peaks that pass FDR <= 0.01 and FDR <= 0.05. - * `*FDR0.01.results.bed`, `*FDR0.05.results.bed`: BED files for peaks that pass FDR <= 0.01 and FDR <= 0.05. - * `*deseq2.plots.pdf`: MA, Volcano, clustering and scatterplots at FDR <= 0.01 and FDR <= 0.05. - * `bwa/mergedLibrary/macs2//consensus//sizeFactors/` - * `*.txt`, `*.RData`: Files containing DESeq2 sizeFactors per sample. +- `bwa/mergedLibrary/macs2//consensus//deseq2/` + - `*.results.txt`: Spreadsheet containing differential binding results across all consensus peaks and all comparisons. + - `*.plots.pdf`: File containing PCA and hierarchical clustering plots. + - `*.log`: Log file with information for number of differentially bound intervals at different FDR and fold-change thresholds for each comparison. + - `*.dds.rld.RData`: File containing R `dds` and `rld` objects generated by DESeq2. + - `R_sessionInfo.log`: File containing information about R, the OS and attached or loaded packages. + - `bwa/mergedLibrary/macs2//consensus///` + - `*.results.txt`: Spreadsheet containing comparison-specific DESeq2 output for differential binding results across all peaks. + - `*FDR0.01.results.txt`, `*FDR0.05.results.txt`: Subset of above file for peaks that pass FDR <= 0.01 and FDR <= 0.05. + - `*FDR0.01.results.bed`, `*FDR0.05.results.bed`: BED files for peaks that pass FDR <= 0.01 and FDR <= 0.05. + - `*deseq2.plots.pdf`: MA, Volcano, clustering and scatterplots at FDR <= 0.01 and FDR <= 0.05. + - `bwa/mergedLibrary/macs2//consensus//sizeFactors/` + - `*.txt`, `*.RData`: Files containing DESeq2 sizeFactors per sample.
@@ -255,10 +255,10 @@ By default, all possible pairwise comparisons across the groups from a particula
Output files -* `multiqc//` - * `multiqc_report.html`: A standalone HTML file that can be viewed in your web browser. - * `multiqc_data/`: Directory containing parsed statistics from the different tools used in the pipeline. - * `multiqc_plots/`: Directory containing static images from the report in various formats. +- `multiqc//` + - `multiqc_report.html`: A standalone HTML file that can be viewed in your web browser. + - `multiqc_data/`: Directory containing parsed statistics from the different tools used in the pipeline. + - `multiqc_plots/`: Directory containing static images from the report in various formats.
@@ -273,9 +273,9 @@ The pipeline has special steps which also allow the software versions to be repo
Output files -* `igv//` - * `igv_session.xml`: Session file that can be directly loaded into IGV. - * `igv_files.txt`: File containing a listing of the files used to create the IGV session. +- `igv//` + - `igv_session.xml`: Session file that can be directly loaded into IGV. + - `igv_files.txt`: File containing a listing of the files used to create the IGV session.
@@ -298,14 +298,15 @@ Once installed, open IGV, go to `File > Open Session` and select the `igv_sessio
Output files -* `genome/` - * A number of genome-specific files are generated by the pipeline in order to aid in the filtering of the data, and because they are required by standard tools such as BEDTools. These can be found in this directory along with the genome fasta file which is required by IGV. If using a genome from AWS iGenomes and if it exists a `README.txt` file containing information about the annotation version will also be saved in this directory. -* `genome/index/` - * `bwa/`: Directory containing BWA indices. - * `bowtie2/`: Directory containing BOWTIE2 indices. - * `star/`: Directory containing STAR indices. +- `genome/` + - A number of genome-specific files are generated by the pipeline in order to aid in the filtering of the data, and because they are required by standard tools such as BEDTools. These can be found in this directory along with the genome fasta file which is required by IGV. If using a genome from AWS iGenomes and if it exists a `README.txt` file containing information about the annotation version will also be saved in this directory. +- `genome/index/` - * If the `--save_reference` parameter is provided then the alignment indices generated by the pipeline will be saved in this directory. This can be quite a time-consuming process so it permits their reuse for future runs of the pipeline or for other purposes. + - `bwa/`: Directory containing BWA indices. + - `bowtie2/`: Directory containing BOWTIE2 indices. + - `star/`: Directory containing STAR indices. + + - If the `--save_reference` parameter is provided then the alignment indices generated by the pipeline will be saved in this directory. This can be quite a time-consuming process so it permits their reuse for future runs of the pipeline or for other purposes.
diff --git a/docs/usage.md b/docs/usage.md index ed885d59c..971a3c897 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -63,13 +63,13 @@ NAIVE_INPUT_REP2,BLA203A48_S39_L001_R1_001.fastq.gz,,, NAIVE_INPUT_REP3,BLA203A49_S1_L006_R1_001.fastq.gz,,, ``` -| Column | Description | -|----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------| -| `sample` | Custom sample name. This entry will be identical for multiple sequencing libraries/runs from the same sample. Spaces in sample names are automatically converted to underscores (`_`). | -| `fastq_1` | Full path to FastQ file for Illumina short reads 1. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | -| `fastq_2` | Full path to FastQ file for Illumina short reads 2. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | -| `antibody` | Antibody name. This is required to segregate downstream analysis for different antibodies. Required when `control` is specified. | -| `control` | Sample name for control sample. | +| Column | Description | +| ---------- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | +| `sample` | Custom sample name. This entry will be identical for multiple sequencing libraries/runs from the same sample. Spaces in sample names are automatically converted to underscores (`_`). | +| `fastq_1` | Full path to FastQ file for Illumina short reads 1. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | +| `fastq_2` | Full path to FastQ file for Illumina short reads 2. File has to be gzipped and have the extension ".fastq.gz" or ".fq.gz". | +| `antibody` | Antibody name. This is required to segregate downstream analysis for different antibodies. Required when `control` is specified. | +| `control` | Sample name for control sample. | Example design files have been provided with the pipeline for [paired-end](../assets/samplesheet_pe.csv) and [single-end](../assets/samplesheet_se.csv) data. @@ -79,8 +79,8 @@ Example design files have been provided with the pipeline for [paired-end](../as The minimum reference genome requirements are a FASTA and GTF file, all other files required to run the pipeline can be generated from these files. However, it is more storage and compute friendly if you are able to re-use reference genome files as efficiently as possible. It is recommended to use the `--save_reference` parameter if you are using the pipeline to build new indices (e.g. those unavailable on [AWS iGenomes](https://nf-co.re/usage/reference_genomes)) so that you can save them somewhere locally. The index building step can be quite a time-consuming process and it permits their reuse for future runs of the pipeline to save disk space. You can then either provide the appropriate reference genome files on the command-line via the appropriate parameters (e.g. `--bwa_index '/path/to/bwa/index/'`) or via a custom config file. -* If `--genome` is provided then the FASTA and GTF files (and existing indices) will be automatically obtained from AWS-iGenomes unless these have already been downloaded locally in the path specified by `--igenomes_base`. -* If `--gene_bed` is not provided then it will be generated from the GTF file. +- If `--genome` is provided then the FASTA and GTF files (and existing indices) will be automatically obtained from AWS-iGenomes unless these have already been downloaded locally in the path specified by `--igenomes_base`. +- If `--gene_bed` is not provided then it will be generated from the GTF file. > **NB:** Compressed reference files are also supported by the pipeline i.e. standard files with the `.gz` extension and indices folders with the `tar.gz` extension. diff --git a/modules/nf-core/modules/macs2/callpeak/meta.yml b/modules/nf-core/modules/macs2/callpeak/meta.yml index 974ea33a6..982bc5b24 100644 --- a/modules/nf-core/modules/macs2/callpeak/meta.yml +++ b/modules/nf-core/modules/macs2/callpeak/meta.yml @@ -28,8 +28,7 @@ input: description: The control file - macs2_gsize: type: string - description: - Effective genome size. It can be 1.0e+9 or 1000000000, or shortcuts:'hs' for human (2.7e9), + description: Effective genome size. It can be 1.0e+9 or 1000000000, or shortcuts:'hs' for human (2.7e9), 'mm' for mouse (1.87e9), 'ce' for C. elegans (9e7) and 'dm' for fruitfly (1.2e8) output: diff --git a/nextflow_schema.json b/nextflow_schema.json index a8028be6d..f8a9b0ccd 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -209,11 +209,7 @@ "default": "bwa", "description": "Specifies the alignment algorithm to use - available options are 'bwa', 'bowtie2' and 'star'.", "fa_icon": "fas fa-map-signs", - "enum": [ - "bwa", - "bowtie2", - "star" - ] + "enum": ["bwa", "bowtie2", "star"] }, "keep_dups": { "type": "boolean", @@ -256,7 +252,6 @@ "description": "BAMTools JSON file with custom filters for single-end data.", "fa_icon": "fas fa-cog" } - } }, "peak_calling_options": { @@ -490,14 +485,7 @@ "description": "Method used to save pipeline results to output directory.", "help_text": "The Nextflow `publishDir` option specifies which intermediate files should be saved to the output directory. This option tells the pipeline what method should be used to move these files. See [Nextflow docs](https://www.nextflow.io/docs/latest/process.html#publishdir) for details.", "fa_icon": "fas fa-copy", - "enum": [ - "symlink", - "rellink", - "link", - "copy", - "copyNoFollow", - "move" - ], + "enum": ["symlink", "rellink", "link", "copy", "copyNoFollow", "move"], "hidden": true }, "fingerprint_bins": { diff --git a/package-lock.json b/package-lock.json new file mode 100644 index 000000000..6440c433a --- /dev/null +++ b/package-lock.json @@ -0,0 +1,20 @@ +{ + "name": "nf-core-chipseq", + "lockfileVersion": 2, + "requires": true, + "packages": { + "": { + "devDependencies": { + "prettier": "npm:undefined@*" + } + }, + "node_modules/prettier": { + "dev": true + } + }, + "dependencies": { + "prettier": { + "dev": true + } + } +} diff --git a/package.json b/package.json new file mode 100644 index 000000000..3a05ceeb0 --- /dev/null +++ b/package.json @@ -0,0 +1,5 @@ +{ + "devDependencies": { + "prettier": "npm:undefined@*" + } +} From daf3bba0e5869867717aad5ebab285c680ad77fe Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 28 Mar 2022 15:23:32 +0200 Subject: [PATCH 358/538] Update macs2 callpeak --- modules.json | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/modules.json b/modules.json index 91121d9ff..82f79253b 100644 --- a/modules.json +++ b/modules.json @@ -46,7 +46,7 @@ "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "macs2/callpeak": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + "git_sha": "f0800157544a82ae222931764483331a81812012" }, "multiqc": { "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" @@ -95,4 +95,4 @@ } } } -} +} \ No newline at end of file From 71ec9d80432d91f2dec0f8090831b30e09212014 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 28 Mar 2022 15:27:35 +0200 Subject: [PATCH 359/538] Trying to finally make prettier happy --- .nf-core.yml | 1 - modules.json | 2 +- nextflow_schema.json | 5 +---- package-lock.json | 20 -------------------- package.json | 5 ----- 5 files changed, 2 insertions(+), 31 deletions(-) delete mode 100644 package-lock.json delete mode 100644 package.json diff --git a/.nf-core.yml b/.nf-core.yml index 2252e0a5f..f1d2ac4ed 100644 --- a/.nf-core.yml +++ b/.nf-core.yml @@ -6,4 +6,3 @@ lint: - .github/workflows/linting.yml - .github/PULL_REQUEST_TEMPLATE.md - bin/check_samplesheet.py - diff --git a/modules.json b/modules.json index 82f79253b..f631a1bcb 100644 --- a/modules.json +++ b/modules.json @@ -95,4 +95,4 @@ } } } -} \ No newline at end of file +} diff --git a/nextflow_schema.json b/nextflow_schema.json index 58c0dfb9b..f8a9b0ccd 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -10,10 +10,7 @@ "type": "object", "fa_icon": "fas fa-terminal", "description": "Define where the pipeline should find input data and save output data.", - "required": [ - "input", - "outdir" - ], + "required": ["input", "outdir"], "properties": { "input": { "type": "string", diff --git a/package-lock.json b/package-lock.json deleted file mode 100644 index 6440c433a..000000000 --- a/package-lock.json +++ /dev/null @@ -1,20 +0,0 @@ -{ - "name": "nf-core-chipseq", - "lockfileVersion": 2, - "requires": true, - "packages": { - "": { - "devDependencies": { - "prettier": "npm:undefined@*" - } - }, - "node_modules/prettier": { - "dev": true - } - }, - "dependencies": { - "prettier": { - "dev": true - } - } -} diff --git a/package.json b/package.json deleted file mode 100644 index 3a05ceeb0..000000000 --- a/package.json +++ /dev/null @@ -1,5 +0,0 @@ -{ - "devDependencies": { - "prettier": "npm:undefined@*" - } -} From b76c9060081fa1e09575dd4c403ef7785a69e695 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 30 Mar 2022 14:10:35 +0200 Subject: [PATCH 360/538] Install chromap 0.2.1 module --- modules.json | 8 +- .../nf-core/modules/chromap/chromap/main.nf | 95 +++++++++++++++++++ .../nf-core/modules/chromap/chromap/meta.yml | 88 +++++++++++++++++ modules/nf-core/modules/chromap/index/main.nf | 36 +++++++ .../nf-core/modules/chromap/index/meta.yml | 33 +++++++ 5 files changed, 259 insertions(+), 1 deletion(-) create mode 100644 modules/nf-core/modules/chromap/chromap/main.nf create mode 100644 modules/nf-core/modules/chromap/chromap/meta.yml create mode 100644 modules/nf-core/modules/chromap/index/main.nf create mode 100644 modules/nf-core/modules/chromap/index/meta.yml diff --git a/modules.json b/modules.json index f631a1bcb..63e09554a 100644 --- a/modules.json +++ b/modules.json @@ -15,6 +15,12 @@ "bwa/mem": { "git_sha": "950700bcdc0e9a2b6883d40d2c51c6fc435cd714" }, + "chromap/chromap": { + "git_sha": "dbb46c9b635080b132bab4b8d5b9a14f0d1c22e7" + }, + "chromap/index": { + "git_sha": "dbb46c9b635080b132bab4b8d5b9a14f0d1c22e7" + }, "custom/dumpsoftwareversions": { "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, @@ -95,4 +101,4 @@ } } } -} +} \ No newline at end of file diff --git a/modules/nf-core/modules/chromap/chromap/main.nf b/modules/nf-core/modules/chromap/chromap/main.nf new file mode 100644 index 000000000..bf3d1234c --- /dev/null +++ b/modules/nf-core/modules/chromap/chromap/main.nf @@ -0,0 +1,95 @@ +process CHROMAP_CHROMAP { + tag "$meta.id" + label 'process_medium' + + conda (params.enable_conda ? "bioconda::chromap=0.2.1 bioconda::samtools=1.15" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:bd74d08a359024829a7aec1638a28607bbcd8a58-0' : + 'quay.io/biocontainers/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:bd74d08a359024829a7aec1638a28607bbcd8a58-0' }" + + input: + tuple val(meta), path(reads) + path fasta + path index + path barcodes + path whitelist + path chr_order + path pairs_chr_order + + output: + tuple val(meta), path("*.bed.gz") , optional:true, emit: bed + tuple val(meta), path("*.bam") , optional:true, emit: bam + tuple val(meta), path("*.tagAlign.gz"), optional:true, emit: tagAlign + tuple val(meta), path("*.pairs.gz") , optional:true, emit: pairs + path "versions.yml" , emit: versions + + when: + task.ext.when == null || task.ext.when + + script: + def args = task.ext.args ?: '' + def args2 = task.ext.args2 ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" + def args_list = args.tokenize() + + def file_extension = args.contains("--SAM") ? 'sam' : args.contains("--TagAlign")? 'tagAlign' : args.contains("--pairs")? 'pairs' : 'bed' + if (barcodes) { + args_list << "-b ${barcodes.join(',')}" + if (whitelist) { + args_list << "--barcode-whitelist $whitelist" + } + } + if (chr_order) { + args_list << "--chr-order $chr_order" + } + if (pairs_chr_order){ + args_list << "--pairs-natural-chr-order $pairs_chr_order" + } + def final_args = args_list.join(' ') + def compression_cmds = "gzip -n ${prefix}.${file_extension}" + if (args.contains("--SAM")) { + compression_cmds = """ + samtools view $args2 -@ $task.cpus -bh \\ + -o ${prefix}.bam ${prefix}.${file_extension} + rm ${prefix}.${file_extension} + """ + } + if (meta.single_end) { + """ + chromap \\ + $final_args \\ + -t $task.cpus \\ + -x $index \\ + -r $fasta \\ + -1 ${reads.join(',')} \\ + -o ${prefix}.${file_extension} + + $compression_cmds + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + chromap: \$(echo \$(chromap --version 2>&1)) + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + END_VERSIONS + """ + } else { + """ + chromap \\ + $final_args \\ + -t $task.cpus \\ + -x $index \\ + -r $fasta \\ + -1 ${reads[0]} \\ + -2 ${reads[1]} \\ + -o ${prefix}.${file_extension} + + $compression_cmds + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + chromap: \$(echo \$(chromap --version 2>&1)) + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + END_VERSIONS + """ + } +} diff --git a/modules/nf-core/modules/chromap/chromap/meta.yml b/modules/nf-core/modules/chromap/chromap/meta.yml new file mode 100644 index 000000000..a86fddc99 --- /dev/null +++ b/modules/nf-core/modules/chromap/chromap/meta.yml @@ -0,0 +1,88 @@ +name: chromap_chromap +description: | + Performs preprocessing and alignment of chromatin fastq files to + fasta reference files using chromap. +keywords: + - chromap + - alignment + - map + - fastq + - bam + - sam + - hi-c + - atac-seq + - chip-seq + - trimming + - duplicate removal +tools: + - chromap: + description: Fast alignment and preprocessing of chromatin profiles + homepage: https://github.com/haowenz/chromap + documentation: https://github.com/haowenz/chromap + tool_dev_url: https://github.com/haowenz/chromap + doi: "" + licence: ["GPL v3"] +input: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - reads: + type: file + description: | + List of input FastQ files of size 1 and 2 for single-end and paired-end data, + respectively. + - fasta: + type: file + description: | + The fasta reference file. + - index: + type: file + description: | + Chromap genome index files (*.index) + - barcodes: + type: file + description: | + Cell barcode files + - whitelist: + type: file + description: | + Cell barcode whitelist file + - chr_order: + type: file + description: | + Custom chromosome order + - pairs_chr_order: + type: file + description: | + Natural chromosome order for pairs flipping +output: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" + - bed: + type: file + description: BED file + pattern: "*.bed.gz" + - bam: + type: file + description: BAM file + pattern: "*.bam" + - tagAlign: + type: file + description: tagAlign file + pattern: "*.tagAlign.gz" + - pairs: + type: file + description: pairs file + pattern: "*.pairs.gz" + +authors: + - "@mahesh-panchal" diff --git a/modules/nf-core/modules/chromap/index/main.nf b/modules/nf-core/modules/chromap/index/main.nf new file mode 100644 index 000000000..ee3706959 --- /dev/null +++ b/modules/nf-core/modules/chromap/index/main.nf @@ -0,0 +1,36 @@ +process CHROMAP_INDEX { + tag "$fasta" + label 'process_medium' + + conda (params.enable_conda ? "bioconda::chromap=0.2.1" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/chromap:0.2.1--hd03093a_0' : + 'quay.io/biocontainers/chromap:0.2.1--hd03093a_0' }" + + input: + path fasta + + output: + path "*.index" , emit: index + path "versions.yml", emit: versions + + when: + task.ext.when == null || task.ext.when + + script: + def args = task.ext.args ?: '' + def prefix = fasta.baseName + """ + chromap \\ + -i \\ + $args \\ + -t $task.cpus \\ + -r $fasta \\ + -o ${prefix}.index + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + chromap: \$(echo \$(chromap --version 2>&1)) + END_VERSIONS + """ +} diff --git a/modules/nf-core/modules/chromap/index/meta.yml b/modules/nf-core/modules/chromap/index/meta.yml new file mode 100644 index 000000000..6659221f6 --- /dev/null +++ b/modules/nf-core/modules/chromap/index/meta.yml @@ -0,0 +1,33 @@ +name: chromap_index +description: Indexes a fasta reference genome ready for chromatin profiling. +keywords: + - index + - fasta + - genome + - reference +tools: + - chromap: + description: Fast alignment and preprocessing of chromatin profiles + homepage: https://github.com/haowenz/chromap + documentation: https://github.com/haowenz/chromap + tool_dev_url: https://github.com/haowenz/chromap + doi: "" + licence: ["GPL v3"] + +input: + - fasta: + type: file + description: Fasta reference file. + +output: + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" + - index: + type: file + description: Index file of the reference genome + pattern: "*.{index}" + +authors: + - "@mahesh-panchal" From 2e3af0dd98bdd2643aafca42b911def74494f1fb Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 30 Mar 2022 14:24:02 +0200 Subject: [PATCH 361/538] Add chromap as mapper --- conf/modules.config | 26 ++++++++++++++++++ main.nf | 1 + nextflow_schema.json | 6 +++++ subworkflows/local/prepare_genome.nf | 20 ++++++++++++++ subworkflows/nf-core/align_chromap.nf | 38 +++++++++++++++++++++++++++ workflows/chipseq.nf | 26 +++++++++++++----- 6 files changed, 111 insertions(+), 6 deletions(-) create mode 100644 subworkflows/nf-core/align_chromap.nf diff --git a/conf/modules.config b/conf/modules.config index 75639a693..a1c8b5a9b 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -221,6 +221,32 @@ if (params.aligner == 'bowtie2') { } } + +if (params.aligner == 'chromap') { + process { + withName: CHROMAP_INDEX { + ext.args = '' + publishDir = [ + path: { "${params.outdir}/genome/${params.aligner}/index" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + withName: CHROMAP_CHROMAP { + ext.args = [ + '--preset chip', + '--SAM' + ].join(' ').trim() + ext.prefix = { "${meta.id}.Lb" } + publishDir = [ + path: { "${params.outdir}/${params.aligner}/library" }, + mode: 'copy', + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + } +} + if (params.aligner == 'star') { process { withName: '.*:ALIGN_STAR:STAR_ALIGN' { diff --git a/main.nf b/main.nf index a57176009..b91365fac 100755 --- a/main.nf +++ b/main.nf @@ -20,6 +20,7 @@ nextflow.enable.dsl = 2 params.fasta = WorkflowMain.getGenomeAttribute(params, 'fasta') params.bwa_index = WorkflowMain.getGenomeAttribute(params, 'bwa') params.bowtie2_index = WorkflowMain.getGenomeAttribute(params, 'bowtie2') +params.chromap_index = WorkflowMain.getGenomeAttribute(params, 'chromap') params.star_index = WorkflowMain.getGenomeAttribute(params, 'star') params.gtf = WorkflowMain.getGenomeAttribute(params, 'gtf') params.gff = WorkflowMain.getGenomeAttribute(params, 'gff') diff --git a/nextflow_schema.json b/nextflow_schema.json index f8a9b0ccd..df595341c 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -103,6 +103,12 @@ "fa_icon": "fas fa-bezier-curve", "description": "Path to directory or tar.gz archive for pre-built Bowtie2 index." }, + "chromap_index": { + "type": "string", + "format": "path", + "fa_icon": "fas fa-bezier-curve", + "description": "Path to directory or tar.gz archive for pre-built Chromap index." + }, "star_index": { "type": "string", "format": "path", diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index a88d05725..e271da03d 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -18,6 +18,7 @@ include { GFFREAD } from '../../modules/nf-core/modules/gffread/mai include { CUSTOM_GETCHROMSIZES } from '../../modules/nf-core/modules/custom/getchromsizes/main' include { BWA_INDEX } from '../../modules/nf-core/modules/bwa/index/main' include { BOWTIE2_BUILD } from '../../modules/nf-core/modules/bowtie2/build/main' +include { CHROMAP_INDEX } from '../../modules/nf-core/modules/chromap/index/main' include { GTF2BED } from '../../modules/local/gtf2bed' include { GENOME_BLACKLIST_REGIONS } from '../../modules/local/genome_blacklist_regions' @@ -158,6 +159,24 @@ workflow PREPARE_GENOME { } } + // + // Uncompress CHROMAP index or generate from scratch if required + // + ch_chromap_index = Channel.empty() + if (prepare_tool_index == 'chromap') { + if (params.chromap_index) { + if (params.chromap_index.endsWith('.tar.gz')) { + ch_chromap_index = UNTAR ( params.chromap_index ).untar + ch_versions = ch_versions.mix(UNTAR.out.versions) + } else { + ch_chromap_index = file(params.chromap_index) + } + } else { + ch_chromap_index = CHROMAP_INDEX ( ch_fasta ).index + ch_versions = ch_versions.mix(CHROMAP_INDEX.out.versions) + } + } + // // Uncompress STAR index or generate from scratch if required // @@ -184,6 +203,7 @@ workflow PREPARE_GENOME { filtered_bed = ch_genome_filtered_bed // path: *.include_regions.bed bwa_index = ch_bwa_index // path: bwa/index/ bowtie2_index = ch_bowtie2_index // path: bowtie2/index/ + chromap_index = ch_chromap_index // path: genome.index star_index = ch_star_index // path: star/index/ versions = ch_versions.ifEmpty(null) // channel: [ versions.yml ] diff --git a/subworkflows/nf-core/align_chromap.nf b/subworkflows/nf-core/align_chromap.nf new file mode 100644 index 000000000..5afa99bc2 --- /dev/null +++ b/subworkflows/nf-core/align_chromap.nf @@ -0,0 +1,38 @@ +/* + * Map reads, sort, index BAM file and run samtools stats, flagstat and idxstats + */ + +include { CHROMAP_CHROMAP } from '../../modules/nf-core/modules/chromap/chromap/main' +include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' + +workflow ALIGN_CHROMAP { + take: + reads // channel: [ val(meta), [ reads ] ] + index // path: /path/to/index + fasta // path: /path/to/fasta + + main: + + ch_versions = Channel.empty() + + // + // Map reads with CHROMAP + // + CHROMAP_CHROMAP(reads, fasta, index, [], [], [], []) + ch_versions = ch_versions.mix(CHROMAP_CHROMAP.out.versions.first()) + + // + // Sort, index BAM file and run samtools stats, flagstat and idxstats + // + BAM_SORT_SAMTOOLS(CHROMAP_CHROMAP.out.bam) + ch_versions = ch_versions.mix(BAM_SORT_SAMTOOLS.out.versions.first()) + + emit: + bam = BAM_SORT_SAMTOOLS.out.bam // channel: [ val(meta), [ bam ] ] + bai = BAM_SORT_SAMTOOLS.out.bai // channel: [ val(meta), [ bai ] ] + stats = BAM_SORT_SAMTOOLS.out.stats // channel: [ val(meta), [ stats ] ] + flagstat = BAM_SORT_SAMTOOLS.out.flagstat // channel: [ val(meta), [ flagstat ] ] + idxstats = BAM_SORT_SAMTOOLS.out.idxstats // channel: [ val(meta), [ idxstats ] ] + + versions = ch_versions // path: versions.yml +} diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 61516c9a0..698f93839 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -5,7 +5,7 @@ */ def valid_params = [ - aligners : [ 'bwa', 'bowtie2', 'star' ] + aligners : [ 'bwa', 'bowtie2', 'chromap', 'star' ] ] def summary_params = NfcoreSchema.paramsSummaryMap(workflow, params) @@ -18,7 +18,7 @@ def checkPathParamList = [ params.input, params.multiqc_config, params.fasta, params.gtf, params.gff, params.gene_bed, - params.bwa_index, params.bowtie2_index, params.star_index, + params.bwa_index, params.bowtie2_index, params.chromap_index, params.star_index, params.blacklist, params.bamtools_filter_pe_config, params.bamtools_filter_se_config ] @@ -27,10 +27,6 @@ for (param in checkPathParamList) { if (param) { file(param, checkIfExists: true // Check mandatory parameters if (params.input) { ch_input = file(params.input) } else { exit 1, 'Input samplesheet not specified!' } -// Check alignment parameters -def prepareToolIndices = [] -// if (!params.skip_alignment) { prepareToolIndices << params.aligner } //DEL - // Save AWS IGenomes file containing annotation version def anno_readme = params.genomes[ params.genome ]?.readme if (anno_readme && file(anno_readme).exists()) { @@ -118,6 +114,7 @@ include { HOMER_ANNOTATEPEAKS as HOMER_ANNOTATEPEAKS_CONSENSUS } from '../module include { FASTQC_TRIMGALORE } from '../subworkflows/nf-core/fastqc_trimgalore' include { ALIGN_BWA_MEM } from '../subworkflows/nf-core/align_bwa_mem' include { ALIGN_BOWTIE2 } from '../subworkflows/nf-core/align_bowtie2' +include { ALIGN_CHROMAP } from '../subworkflows/nf-core/align_chromap' include { ALIGN_STAR } from '../subworkflows/nf-core/align_star' include { MARK_DUPLICATES_PICARD } from '../subworkflows/nf-core/mark_duplicates_picard' @@ -199,6 +196,23 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(ALIGN_BOWTIE2.out.versions.first()) } + // + // SUBWORKFLOW: Alignment with CHROMAP & BAM QC + // + if (params.aligner == 'chromap') { + ALIGN_CHROMAP ( + FASTQC_TRIMGALORE.out.reads, + PREPARE_GENOME.out.chromap_index, + PREPARE_GENOME.out.fasta + ) + ch_genome_bam = ALIGN_CHROMAP.out.bam + ch_genome_bam_index = ALIGN_CHROMAP.out.bai + ch_samtools_stats = ALIGN_CHROMAP.out.stats + ch_samtools_flagstat = ALIGN_CHROMAP.out.flagstat + ch_samtools_idxstats = ALIGN_CHROMAP.out.idxstats + ch_versions = ch_versions.mix(ALIGN_CHROMAP.out.versions.first()) + } + // // SUBWORKFLOW: Alignment with STAR & BAM QC // From 3797d2d825b59326138801a04a46783039775ecc Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 30 Mar 2022 15:06:39 +0200 Subject: [PATCH 362/538] Add chromap as a choice for aligner (schema) --- nextflow_schema.json | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index df595341c..cb99b41f5 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -215,7 +215,7 @@ "default": "bwa", "description": "Specifies the alignment algorithm to use - available options are 'bwa', 'bowtie2' and 'star'.", "fa_icon": "fas fa-map-signs", - "enum": ["bwa", "bowtie2", "star"] + "enum": ["bwa", "bowtie2", "chromap", "star"] }, "keep_dups": { "type": "boolean", From dbdefe6235d1276a3a1a11d9a65c095f5c55e754 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 30 Mar 2022 15:08:43 +0200 Subject: [PATCH 363/538] Make prettier happy --- modules.json | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/modules.json b/modules.json index 63e09554a..c417bcb98 100644 --- a/modules.json +++ b/modules.json @@ -101,4 +101,4 @@ } } } -} \ No newline at end of file +} From 3fc73c3828846efb769dab288f17af56dbee563c Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 30 Mar 2022 15:17:12 +0200 Subject: [PATCH 364/538] Update changelog --- CHANGELOG.md | 1 + 1 file changed, 1 insertion(+) diff --git a/CHANGELOG.md b/CHANGELOG.md index acc542769..995ed3a46 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -7,6 +7,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 ### Enhancements & fixes +- [[#233](https://github.com/nf-core/chipseq/issues/233)] - Add `chromap` to the available aligners - Update pipeline template to nf-core/tools `2.2` - Port pipeline to the updated Nextflow DSL2 syntax adopted on nf-core/modules - Removed `--publish_dir_mode` as it is no longer required for the new syntax From ffa1038f55e63bf65cdf07dfeebc2b7a8df19742 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 30 Mar 2022 22:13:31 +0200 Subject: [PATCH 365/538] Apply review suggestions --- conf/modules.config | 5 +---- subworkflows/nf-core/align_chromap.nf | 6 +++--- 2 files changed, 4 insertions(+), 7 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index a1c8b5a9b..560853be8 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -233,10 +233,7 @@ if (params.aligner == 'chromap') { ] } withName: CHROMAP_CHROMAP { - ext.args = [ - '--preset chip', - '--SAM' - ].join(' ').trim() + ext.args = '--preset chip --SAM' ext.prefix = { "${meta.id}.Lb" } publishDir = [ path: { "${params.outdir}/${params.aligner}/library" }, diff --git a/subworkflows/nf-core/align_chromap.nf b/subworkflows/nf-core/align_chromap.nf index 5afa99bc2..7eb739779 100644 --- a/subworkflows/nf-core/align_chromap.nf +++ b/subworkflows/nf-core/align_chromap.nf @@ -7,9 +7,9 @@ include { BAM_SORT_SAMTOOLS } from './bam_sort_samtools' workflow ALIGN_CHROMAP { take: - reads // channel: [ val(meta), [ reads ] ] - index // path: /path/to/index - fasta // path: /path/to/fasta + reads // channel: [ val(meta), [ reads ] ] + index // path: /path/to/index + fasta // path: /path/to/fasta main: From 3800855ecb73bf22fad5ccaad34094756b3e062f Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 30 Mar 2022 23:18:52 +0200 Subject: [PATCH 366/538] 1st iteration for filtering macs2 files without peaks --- workflows/chipseq.nf | 33 +++++++++++++++++++++++++-------- 1 file changed, 25 insertions(+), 8 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 698f93839..90d37a202 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -263,7 +263,7 @@ workflow CHIPSEQ { // FILTER_BAM_BAMTOOLS ( MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), - PREPARE_GENOME.out.filtered_bed, + PREPARE_GENOME.out.filtered_bed.first(), ch_bamtools_filter_se_config, ch_bamtools_filter_pe_config @@ -405,10 +405,22 @@ workflow CHIPSEQ { ch_ip_control_bam, params.macs_gsize ) + ch_versions = ch_versions.mix(MACS2_CALLPEAK.out.versions.first()) + // + // Filter for MACS2 files without peaks + // + // [[id:SPT5_T15_REP1, single_end:false, antibody:SPT5, control:SPT5_INPUT_REP1], /home/kadomu/nxf_scratch/02/91c628910c3014b2267e2bcff1a82d/SPT5_T15_REP1_peaks.broadPeak] + MACS2_CALLPEAK + .out + .peak + .filter { meta, peaks -> peaks.size() > 0 } + .set { ch_macs2_peaks } + ch_ip_control_bam - .join(MACS2_CALLPEAK.out.peak, by: [0]) + //.join(MACS2_CALLPEAK.out.peak, by: [0]) + .join(ch_macs2_peaks, by: [0]) .map { it -> [ it[0], it[1], it[3] ] } .set { ch_ip_peak } FRIP_SCORE ( @@ -431,12 +443,14 @@ workflow CHIPSEQ { if (!params.skip_peak_annotation && !params.skip_peak_qc) { PLOT_MACS2_QC ( - MACS2_CALLPEAK.out.peak.collect{it[1]} + // MACS2_CALLPEAK.out.peak.collect{it[1]} + ch_macs2_peaks.collect{it[1]} ) ch_versions = ch_versions.mix(PLOT_MACS2_QC.out.versions) HOMER_ANNOTATEPEAKS_MACS2 ( - MACS2_CALLPEAK.out.peak, + // MACS2_CALLPEAK.out.peak + ch_macs2_peaks, PREPARE_GENOME.out.fasta, PREPARE_GENOME.out.gtf ) @@ -457,9 +471,11 @@ workflow CHIPSEQ { if (!params.skip_consensus_peaks) { // Create channel: [ meta , [ peaks ] ] // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] - MACS2_CALLPEAK - .out - .peak + + // MACS2_CALLPEAK + // .out + // .peak + ch_macs2_peaks .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } .groupTuple() .map { @@ -538,7 +554,8 @@ workflow CHIPSEQ { IGV ( PREPARE_GENOME.out.fasta, UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), - MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), + // MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), + ch_macs2_peaks.collect{it[1]}.ifEmpty([]), MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), "bwa/mergedLibrary/bigwig", { ["bwa/mergedLibrary/macs2", From 684906dceb2c013ad2319bf2a82b3a794cd9cc41 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 31 Mar 2022 15:08:06 +0200 Subject: [PATCH 367/538] Fix issue with phantompeakqualtools --- CHANGELOG.md | 1 + modules/local/multiqc_custom_phantompeakqualtools.nf | 2 +- modules/nf-core/modules/phantompeakqualtools/main.nf | 2 +- 3 files changed, 3 insertions(+), 2 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 995ed3a46..b971bd081 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -7,6 +7,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 ### Enhancements & fixes +- [[#220](https://github.com/nf-core/chipseq/issues/220)] - Fix `phantompeakqualtools` protection stack overflow error - [[#233](https://github.com/nf-core/chipseq/issues/233)] - Add `chromap` to the available aligners - Update pipeline template to nf-core/tools `2.2` - Port pipeline to the updated Nextflow DSL2 syntax adopted on nf-core/modules diff --git a/modules/local/multiqc_custom_phantompeakqualtools.nf b/modules/local/multiqc_custom_phantompeakqualtools.nf index d0b1ea9cb..7ee98d2a5 100644 --- a/modules/local/multiqc_custom_phantompeakqualtools.nf +++ b/modules/local/multiqc_custom_phantompeakqualtools.nf @@ -19,7 +19,7 @@ process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { def prefix = task.ext.prefix ?: "${meta.id}" """ cp $correlation_header ${prefix}.spp_correlation_mqc.tsv - Rscript -e "load('$rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}.spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" + Rscript -e --max-ppsize=500000 "load('$rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}.spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" awk -v OFS='\t' '{print "${meta.id}", \$9}' $spp | cat $nsc_header - > ${prefix}.spp_nsc_mqc.tsv awk -v OFS='\t' '{print "${meta.id}", \$10}' $spp | cat $rsc_header - > ${prefix}.spp_rsc_mqc.tsv diff --git a/modules/nf-core/modules/phantompeakqualtools/main.nf b/modules/nf-core/modules/phantompeakqualtools/main.nf index c8325b059..c52892921 100644 --- a/modules/nf-core/modules/phantompeakqualtools/main.nf +++ b/modules/nf-core/modules/phantompeakqualtools/main.nf @@ -26,7 +26,7 @@ process PHANTOMPEAKQUALTOOLS { def prefix = task.ext.prefix ?: "${meta.id}" """ RUN_SPP=`which run_spp.R` - Rscript -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus + Rscript -e --max-ppsize=500000 "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus cat <<-END_VERSIONS > versions.yml "${task.process}": From 3f18b50e86679dd2d4040f52e5b5042c89377928 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 31 Mar 2022 16:42:22 +0200 Subject: [PATCH 368/538] Arguments order matter --- modules/local/multiqc_custom_phantompeakqualtools.nf | 2 +- modules/nf-core/modules/phantompeakqualtools/main.nf | 2 +- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/modules/local/multiqc_custom_phantompeakqualtools.nf b/modules/local/multiqc_custom_phantompeakqualtools.nf index 7ee98d2a5..2e9118237 100644 --- a/modules/local/multiqc_custom_phantompeakqualtools.nf +++ b/modules/local/multiqc_custom_phantompeakqualtools.nf @@ -19,7 +19,7 @@ process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { def prefix = task.ext.prefix ?: "${meta.id}" """ cp $correlation_header ${prefix}.spp_correlation_mqc.tsv - Rscript -e --max-ppsize=500000 "load('$rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}.spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" + Rscript --max-ppsize=500000 -e "load('$rdata'); write.table(crosscorr\\\$cross.correlation, file=\\"${prefix}.spp_correlation_mqc.tsv\\", sep=",", quote=FALSE, row.names=FALSE, col.names=FALSE,append=TRUE)" awk -v OFS='\t' '{print "${meta.id}", \$9}' $spp | cat $nsc_header - > ${prefix}.spp_nsc_mqc.tsv awk -v OFS='\t' '{print "${meta.id}", \$10}' $spp | cat $rsc_header - > ${prefix}.spp_rsc_mqc.tsv diff --git a/modules/nf-core/modules/phantompeakqualtools/main.nf b/modules/nf-core/modules/phantompeakqualtools/main.nf index c52892921..038c7c6ba 100644 --- a/modules/nf-core/modules/phantompeakqualtools/main.nf +++ b/modules/nf-core/modules/phantompeakqualtools/main.nf @@ -26,7 +26,7 @@ process PHANTOMPEAKQUALTOOLS { def prefix = task.ext.prefix ?: "${meta.id}" """ RUN_SPP=`which run_spp.R` - Rscript -e --max-ppsize=500000 "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus + Rscript --max-ppsize=500000 -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus cat <<-END_VERSIONS > versions.yml "${task.process}": From 70c2c76bc26dde61e223d9a1cad8d0b859c5f198 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 1 Apr 2022 09:44:31 +0200 Subject: [PATCH 369/538] Install phantompeakqualtools from modules --- modules.json | 4 +- .../modules/phantompeakqualtools/main.nf | 2 +- .../modules/phantompeakqualtools/meta.yml | 60 +++++++++++++++++++ 3 files changed, 63 insertions(+), 3 deletions(-) create mode 100644 modules/nf-core/modules/phantompeakqualtools/meta.yml diff --git a/modules.json b/modules.json index c417bcb98..bc1fa02c4 100644 --- a/modules.json +++ b/modules.json @@ -58,7 +58,7 @@ "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "phantompeakqualtools": { - "git_sha": "e20e57f90b6787ac9a010a980cf6ea98bd990046" + "git_sha": "5e7daa7b96fa9699a52ac8fa3dcbf4291cc6d050" }, "picard/collectmultiplemetrics": { "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" @@ -101,4 +101,4 @@ } } } -} +} \ No newline at end of file diff --git a/modules/nf-core/modules/phantompeakqualtools/main.nf b/modules/nf-core/modules/phantompeakqualtools/main.nf index 038c7c6ba..f584cb65d 100644 --- a/modules/nf-core/modules/phantompeakqualtools/main.nf +++ b/modules/nf-core/modules/phantompeakqualtools/main.nf @@ -26,7 +26,7 @@ process PHANTOMPEAKQUALTOOLS { def prefix = task.ext.prefix ?: "${meta.id}" """ RUN_SPP=`which run_spp.R` - Rscript --max-ppsize=500000 -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus + Rscript $args -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus cat <<-END_VERSIONS > versions.yml "${task.process}": diff --git a/modules/nf-core/modules/phantompeakqualtools/meta.yml b/modules/nf-core/modules/phantompeakqualtools/meta.yml new file mode 100644 index 000000000..6488500d4 --- /dev/null +++ b/modules/nf-core/modules/phantompeakqualtools/meta.yml @@ -0,0 +1,60 @@ +name: "phantompeakqualtools" + +description: +keywords: + - "ChIP-Seq" + - "QC" + - "phantom peaks" +tools: + - "phantompeakqualtools": + description: | + "This package computes informative enrichment and quality measures + for ChIP-seq/DNase-seq/FAIRE-seq/MNase-seq data. It can also be used + to obtain robust estimates of the predominant fragment length or + characteristic tag shift values in these assays." + homepage: "None" + documentation: "https://github.com/kundajelab/phantompeakqualtools" + tool_dev_url: "https://github.com/kundajelab/phantompeakqualtools" + doi: "https://doi.org/10.1101/gr.136184.111" + licence: "['BSD-3-clause']" + +input: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - bam: + type: file + description: BAM/CRAM/SAM file + pattern: "*.{bam,cram,sam}" + +output: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" + - spp: + type: file + description: | + A ChIP-Seq Processing Pipeline file containing + peakshift/phantomPeak results + pattern: "*.{out}" + - pdf: + type: file + description: A pdf containing save cross-correlation plots + pattern: "*.{pdf}" + - rdata: + type: file + description: Rdata file containing the R session + pattern: "*.{Rdata}" + +authors: + - "@drpatelh" + - "@Emiller88" + - "@JoseEspinosa" From 7ff25bef3caf3955b18ea587bc6e48ea67d0c99b Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 1 Apr 2022 10:03:28 +0200 Subject: [PATCH 370/538] Fix prettier --- modules.json | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/modules.json b/modules.json index bc1fa02c4..bf894642f 100644 --- a/modules.json +++ b/modules.json @@ -101,4 +101,4 @@ } } } -} \ No newline at end of file +} From dae04ece0048b63dec42e97f5a66e2f39ddd0af7 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 19 Apr 2022 18:16:33 +0200 Subject: [PATCH 371/538] Filter empty peaks files --- workflows/chipseq.nf | 12 +----------- 1 file changed, 1 insertion(+), 11 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 90d37a202..f5960e9d3 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -400,18 +400,15 @@ workflow CHIPSEQ { .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } .set { ch_ip_control_bam } - MACS2_CALLPEAK ( ch_ip_control_bam, params.macs_gsize ) - ch_versions = ch_versions.mix(MACS2_CALLPEAK.out.versions.first()) // // Filter for MACS2 files without peaks // - // [[id:SPT5_T15_REP1, single_end:false, antibody:SPT5, control:SPT5_INPUT_REP1], /home/kadomu/nxf_scratch/02/91c628910c3014b2267e2bcff1a82d/SPT5_T15_REP1_peaks.broadPeak] MACS2_CALLPEAK .out .peak @@ -419,10 +416,10 @@ workflow CHIPSEQ { .set { ch_macs2_peaks } ch_ip_control_bam - //.join(MACS2_CALLPEAK.out.peak, by: [0]) .join(ch_macs2_peaks, by: [0]) .map { it -> [ it[0], it[1], it[3] ] } .set { ch_ip_peak } + FRIP_SCORE ( ch_ip_peak ) @@ -443,13 +440,11 @@ workflow CHIPSEQ { if (!params.skip_peak_annotation && !params.skip_peak_qc) { PLOT_MACS2_QC ( - // MACS2_CALLPEAK.out.peak.collect{it[1]} ch_macs2_peaks.collect{it[1]} ) ch_versions = ch_versions.mix(PLOT_MACS2_QC.out.versions) HOMER_ANNOTATEPEAKS_MACS2 ( - // MACS2_CALLPEAK.out.peak ch_macs2_peaks, PREPARE_GENOME.out.fasta, PREPARE_GENOME.out.gtf @@ -471,10 +466,6 @@ workflow CHIPSEQ { if (!params.skip_consensus_peaks) { // Create channel: [ meta , [ peaks ] ] // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] - - // MACS2_CALLPEAK - // .out - // .peak ch_macs2_peaks .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } .groupTuple() @@ -554,7 +545,6 @@ workflow CHIPSEQ { IGV ( PREPARE_GENOME.out.fasta, UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), - // MACS2_CALLPEAK.out.peak.collect{it[1]}.ifEmpty([]), ch_macs2_peaks.collect{it[1]}.ifEmpty([]), MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), "bwa/mergedLibrary/bigwig", From 0ea8f11dec012c43a2ea7e95f1e245bf906a6fab Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 19 Apr 2022 18:17:48 +0200 Subject: [PATCH 372/538] Replace "if" by "when" otherwise error when the if condition is not met --- modules/local/macs2_consensus.nf | 65 +++++++++++++++++--------------- 1 file changed, 34 insertions(+), 31 deletions(-) diff --git a/modules/local/macs2_consensus.nf b/modules/local/macs2_consensus.nf index 7ca2c35e7..cd27807f1 100644 --- a/modules/local/macs2_consensus.nf +++ b/modules/local/macs2_consensus.nf @@ -21,36 +21,39 @@ process MACS2_CONSENSUS { tuple val(meta), path("*.intersect.txt"), emit: intersect_txt path "versions.yml" , emit: versions + when: + (meta.multiple_groups || meta.replicates_exist) + script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - if (meta.multiple_groups || meta.replicates_exist) { - def prefix = task.ext.prefix ?: "${meta.id}" - def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' - def mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') - def collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') - def expandparam = params.narrow_peak ? '--is_narrow_peak' : '' - """ - sort -T '.' -k1,1 -k2,2n ${peaks.collect{it.toString()}.sort().join(' ')} \\ - | mergeBed -c $mergecols -o $collapsecols > ${prefix}.txt - - macs2_merged_expand.py \\ - ${prefix}.txt \\ - ${peaks.collect{it.toString()}.sort().join(',').replaceAll("_peaks.${peak_type}","")} \\ - ${prefix}.boolean.txt \\ - --min_replicates $params.min_reps_consensus \\ - $expandparam - - awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$1, \$2, \$3, \$4, "0", "+" }' ${prefix}.boolean.txt > ${prefix}.bed - - echo -e "GeneID\tChr\tStart\tEnd\tStrand" > ${prefix}.saf - awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$4, \$1, \$2, \$3, "+" }' ${prefix}.boolean.txt >> ${prefix}.saf - - plot_peak_intersect.r -i ${prefix}.boolean.intersect.txt -o ${prefix}.boolean.intersect.plot.pdf - - cat <<-END_VERSIONS > versions.yml - "${task.process}": - python: \$(python --version | sed 's/Python //g') - r-base: \$(echo \$(R --version 2>&1) | sed 's/^.*R version //; s/ .*\$//') - END_VERSIONS - """ - } + + def prefix = task.ext.prefix ?: "${meta.id}" + def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' + def mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') + def collapsecols = params.narrow_peak ? (['collapse']*9).join(',') : (['collapse']*8).join(',') + def expandparam = params.narrow_peak ? '--is_narrow_peak' : '' + """ + sort -T '.' -k1,1 -k2,2n ${peaks.collect{it.toString()}.sort().join(' ')} \\ + | mergeBed -c $mergecols -o $collapsecols > ${prefix}.txt + + macs2_merged_expand.py \\ + ${prefix}.txt \\ + ${peaks.collect{it.toString()}.sort().join(',').replaceAll("_peaks.${peak_type}","")} \\ + ${prefix}.boolean.txt \\ + --min_replicates $params.min_reps_consensus \\ + $expandparam + + awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$1, \$2, \$3, \$4, "0", "+" }' ${prefix}.boolean.txt > ${prefix}.bed + + echo -e "GeneID\tChr\tStart\tEnd\tStrand" > ${prefix}.saf + awk -v FS='\t' -v OFS='\t' 'FNR > 1 { print \$4, \$1, \$2, \$3, "+" }' ${prefix}.boolean.txt >> ${prefix}.saf + + plot_peak_intersect.r -i ${prefix}.boolean.intersect.txt -o ${prefix}.boolean.intersect.plot.pdf + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + python: \$(python --version | sed 's/Python //g') + r-base: \$(echo \$(R --version 2>&1) | sed 's/^.*R version //; s/ .*\$//') + END_VERSIONS + """ + } From 081ff45942d93e4ebb6a55c1c29e0464cd1e9753 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 19 Apr 2022 18:28:54 +0200 Subject: [PATCH 373/538] Update changelog --- CHANGELOG.md | 1 + 1 file changed, 1 insertion(+) diff --git a/CHANGELOG.md b/CHANGELOG.md index b971bd081..42ea62619 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -7,6 +7,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 ### Enhancements & fixes +- [[#128](https://github.com/nf-core/chipseq/issues/128)] - Filter files with no peaks to avoid errors in downstream processes - [[#220](https://github.com/nf-core/chipseq/issues/220)] - Fix `phantompeakqualtools` protection stack overflow error - [[#233](https://github.com/nf-core/chipseq/issues/233)] - Add `chromap` to the available aligners - Update pipeline template to nf-core/tools `2.2` From 31523142591e045cb6d4d1c69c93e1578a7fc210 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 20 Apr 2022 10:15:49 +0200 Subject: [PATCH 374/538] Bring back publish_dir_mode --- conf/modules.config | 110 ++++++++++++++++++++++---------------------- 1 file changed, 55 insertions(+), 55 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 560853be8..f1f4921da 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -46,7 +46,7 @@ process { withName: 'GUNZIP_.*' { publishDir = [ path: { "${params.outdir}/genome" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, enabled: params.save_reference ] @@ -59,7 +59,7 @@ process { withName: 'UNTAR_.*|BWA_INDEX|BOWTIE2_BUILD|STAR_GENOMEGENERATE' { publishDir = [ path: { "${params.outdir}/genome/index" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, enabled: params.save_reference ] @@ -69,7 +69,7 @@ process { ext.args = '--keep-exon-attrs -F -T' publishDir = [ path: { "${params.outdir}/genome" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, enabled: params.save_reference ] @@ -78,7 +78,7 @@ process { withName: 'GTF2BED' { publishDir = [ path: { "${params.outdir}/genome" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, enabled: params.save_reference ] @@ -87,7 +87,7 @@ process { withName: 'CUSTOM_GETCHROMSIZES' { publishDir = [ path: { "${params.outdir}/genome" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, enabled: params.save_reference ] @@ -96,7 +96,7 @@ process { withName: 'GENOME_BLACKLIST_REGIONS' { publishDir = [ path: { "${params.outdir}/genome" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, enabled: params.save_reference ] @@ -114,12 +114,12 @@ if (!(params.skip_fastqc || params.skip_qc)) { publishDir = [ [ path: { "${params.outdir}/fastqc" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: "*.{html}" ], [ path: { "${params.outdir}/fastqc/zips" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: "*.{zip}" ] ] @@ -137,22 +137,22 @@ if (!params.skip_trimming) { publishDir = [ [ path: { "${params.outdir}/trimgalore/fastqc" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: "*.{html}" ], [ path: { "${params.outdir}/trimgalore/fastqc/zips" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: "*.{zip}" ], [ path: { "${params.outdir}/trimgalore/logs" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: "*.txt" ], [ path: { "${params.outdir}/trimgalore" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: "*.fq.gz", enabled: params.save_trimmed ] @@ -166,7 +166,7 @@ process { ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/samtools" }, - mode: 'copy' + mode: params.publish_dir_mode ] } @@ -174,7 +174,7 @@ process { ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/samtools" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -183,7 +183,7 @@ process { ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/library/samtools_stats" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -200,7 +200,7 @@ if (params.aligner == 'bwa') { ext.prefix = { "${meta.id}.Lb" } publishDir = [ path: { "${params.outdir}/${params.aligner}/library" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -214,7 +214,7 @@ if (params.aligner == 'bowtie2') { ext.prefix = { "${meta.id}.Lb" } publishDir = [ path: { "${params.outdir}/${params.aligner}/library" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -228,7 +228,7 @@ if (params.aligner == 'chromap') { ext.args = '' publishDir = [ path: { "${params.outdir}/genome/${params.aligner}/index" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -237,7 +237,7 @@ if (params.aligner == 'chromap') { ext.prefix = { "${meta.id}.Lb" } publishDir = [ path: { "${params.outdir}/${params.aligner}/library" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -260,17 +260,17 @@ if (params.aligner == 'star') { publishDir = [ [ path: { "${params.outdir}/${params.aligner}/log" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: '*.{out,tab}' ], [ path: { "${params.outdir}/${params.aligner}/library" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: '*.bam', ], [ path: { "${params.outdir}/${params.aligner}/unmapped" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: '*.fastq.gz', enabled: params.save_unaligned ] @@ -285,7 +285,7 @@ process { ext.prefix = { "${meta.id}.mLb.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -296,12 +296,12 @@ process { publishDir = [ [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/picard_metrics" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: '*.metrics.txt' ], [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: '*.bam', enabled: params.save_align_intermeds ] @@ -312,7 +312,7 @@ process { ext.prefix = { "${meta.id}.mkD.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: '*.{bai,csi}' ] } @@ -320,7 +320,7 @@ process { withName: '.*:MARK_DUPLICATES_PICARD:BAM_STATS_SAMTOOLS:.*' { publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/samtools_stats" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: '*.{stats,flagstat,idxstats}' ] } @@ -329,7 +329,7 @@ process { ext.prefix = { "${meta.id}.mLb.flT.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, enabled: params.save_align_intermeds ] @@ -340,7 +340,7 @@ process { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -349,7 +349,7 @@ process { ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: '*.{bai,csi}' ] } @@ -358,7 +358,7 @@ process { ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: "*.bam" ] } @@ -367,7 +367,7 @@ process { ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/samtools_stats" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: "*.{stats,flagstat,idxstats}" ] } @@ -376,7 +376,7 @@ process { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/phantompeakqualtools" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: "*.{out,pdf}" ] } @@ -384,7 +384,7 @@ process { withName: 'MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS' { publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/phantompeakqualtools" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -394,12 +394,12 @@ process { publishDir = [ [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: "*.bigWig" ], [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig/scale" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: "*.txt" ] ] @@ -410,7 +410,7 @@ process { publishDir = [ [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: "*.bigWig" ] ] @@ -425,12 +425,12 @@ if (!params.skip_picard_metrics) { publishDir = [ [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/picard_metrics" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: "*_metrics" ], [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/picard_metrics/pdf" }, - mode: 'copy', + mode: params.publish_dir_mode, pattern: "*.pdf" ] ] @@ -445,7 +445,7 @@ if (!params.skip_preseq) { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/preseq" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -459,7 +459,7 @@ if (!params.skip_plot_profile) { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotProfile" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -468,7 +468,7 @@ if (!params.skip_plot_profile) { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotProfile" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -477,7 +477,7 @@ if (!params.skip_plot_profile) { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotProfile" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -494,7 +494,7 @@ if (!params.skip_plot_fingerprint) { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotFingerprint" }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -516,7 +516,7 @@ if (params.macs_gsize) { "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -540,7 +540,7 @@ if (params.macs_gsize) { params.narrow_peak? '/narrowPeak' : '/broadPeak', '/qc' ].join('') }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -556,7 +556,7 @@ if (params.macs_gsize) { params.narrow_peak? '/narrowPeak' : '/broadPeak', '/qc' ].join('') }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -569,7 +569,7 @@ if (params.macs_gsize) { "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -582,7 +582,7 @@ if (params.macs_gsize) { params.narrow_peak? '/narrowPeak' : '/broadPeak', '/qc' ].join('') }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -599,7 +599,7 @@ if (params.macs_gsize) { params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus' ].join('') }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -612,7 +612,7 @@ if (params.macs_gsize) { params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus' ].join('') }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -630,7 +630,7 @@ if (params.macs_gsize) { params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus' ].join('') }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -652,7 +652,7 @@ if (params.macs_gsize) { params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus/deseq2' ].join('') }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -667,7 +667,7 @@ if (params.macs_gsize) { "${params.outdir}/igv", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -684,7 +684,7 @@ if (!params.skip_multiqc) { "${params.outdir}/multiqc", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, - mode: 'copy', + mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } From 265170b7b554d5684f26fc0da01881456a8123ce Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 20 Apr 2022 10:24:19 +0200 Subject: [PATCH 375/538] Update changelog --- CHANGELOG.md | 5 +---- 1 file changed, 1 insertion(+), 4 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 42ea62619..53ca266b4 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -10,14 +10,11 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 - [[#128](https://github.com/nf-core/chipseq/issues/128)] - Filter files with no peaks to avoid errors in downstream processes - [[#220](https://github.com/nf-core/chipseq/issues/220)] - Fix `phantompeakqualtools` protection stack overflow error - [[#233](https://github.com/nf-core/chipseq/issues/233)] - Add `chromap` to the available aligners -- Update pipeline template to nf-core/tools `2.2` +- Updated pipeline template to [nf-core/tools 2.3.2](https://github.com/nf-core/tools/releases/tag/2.3.2) - Port pipeline to the updated Nextflow DSL2 syntax adopted on nf-core/modules - - Removed `--publish_dir_mode` as it is no longer required for the new syntax - Bump minimum Nextflow version from `21.04.0` -> `21.10.3` -- Updated pipeline template to [nf-core/tools 2.2](https://github.com/nf-core/tools/releases/tag/2.2) - Added `python3` shebang to appropriate scripts in `bin/` directory - [[#160](https://github.com/nf-core/chipseq/issues/160)] - Add `bowtie2` and `star` as available aligners, via the `--aligner` parameter -- Update pipeline template to nf-core/tools `2.1` - Add `--save_unaligned` parameter (only available for `bowtie2` and `star`) - Update `igenomes.config` to fetch whole `BWAIndex/version0.6.0/` folder - [[228](https://github.com/nf-core/chipseq/issues/228)] - Update blacklist bed files. From 1f5a9f88813c9f69b7bd28dd2ccce5e8fa13f767 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 20 Apr 2022 15:43:37 +0200 Subject: [PATCH 376/538] Update modules --- assets/multiqc_config.yml | 4 +-- conf/modules.config | 7 +++-- docs/output.md | 2 +- modules.json | 28 +++++++++---------- modules/nf-core/modules/bowtie2/align/main.nf | 6 ++-- modules/nf-core/modules/bwa/mem/main.nf | 8 ++---- .../nf-core/modules/chromap/chromap/main.nf | 6 ++-- modules/nf-core/modules/fastqc/main.nf | 12 ++++++++ modules/nf-core/modules/multiqc/main.nf | 12 ++++++++ .../picard/collectmultiplemetrics/main.nf | 20 +++++++++++++ .../modules/picard/markduplicates/main.nf | 13 +++++++++ .../nf-core/modules/preseq/lcextrap/main.nf | 12 ++++---- .../nf-core/modules/preseq/lcextrap/meta.yml | 9 +++--- .../nf-core/modules/samtools/idxstats/main.nf | 6 ++-- .../nf-core/modules/samtools/index/main.nf | 18 ++++++++++-- modules/nf-core/modules/samtools/sort/main.nf | 17 +++++++++-- .../nf-core/modules/samtools/stats/main.nf | 17 +++++++++-- modules/nf-core/modules/untar/main.nf | 27 ++++++++++++------ modules/nf-core/modules/untar/meta.yml | 10 +++++++ subworkflows/local/prepare_genome.nf | 6 ++-- workflows/chipseq.nf | 2 +- 21 files changed, 177 insertions(+), 65 deletions(-) diff --git a/assets/multiqc_config.yml b/assets/multiqc_config.yml index ad69b5d8a..1a55a16cb 100644 --- a/assets/multiqc_config.yml +++ b/assets/multiqc_config.yml @@ -155,7 +155,7 @@ extra_fn_clean_exts: - ".peak" - "_spp" - ".spp" - - "ccurve" + - "lc_extrap" # # Customise the module search patterns to speed up execution time # # - Skip module sub-tools that we are not interested in @@ -166,7 +166,7 @@ sp: cutadapt: fn: "*trimming_report.txt" preseq: - fn: "*.ccurve.txt" + fn: "*.lc_extrap.txt" deeptools/plotFingerprintOutRawCounts: fn: "*plotFingerprint*" deeptools/plotProfile: diff --git a/conf/modules.config b/conf/modules.config index f1f4921da..4d0988886 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -192,10 +192,11 @@ process { if (params.aligner == 'bwa') { process { withName: 'BWA_MEM' { - ext.args = [ + ext.args = { [ '-M', - params.bwa_min_score ? " -T ${params.bwa_min_score}" : '' - ].join(' ').trim() + params.bwa_min_score ? " -T ${params.bwa_min_score}" : '', + meta.read_group ? "-R ${meta.read_group}": '' + ].join(' ').trim() } ext.args2 = '-bhS -F 0x0100 -O BAM' ext.prefix = { "${meta.id}.Lb" } publishDir = [ diff --git a/docs/output.md b/docs/output.md index 88b9b99bf..c80fb81a1 100644 --- a/docs/output.md +++ b/docs/output.md @@ -87,7 +87,7 @@ The library-level alignments associated with the same sample are merged and subs - `bwa/mergedLibrary/picard_metrics/pdf/` - `*.pdf`: Alignment QC plot files from picard CollectMultipleMetrics. - `bwa/mergedLibrary/preseq/` - - `*.ccurve.txt`: Preseq expected future yield file. + - `*.lc_extrap.txt`: Preseq expected future yield file. > **NB:** File names in the resulting directory (i.e. `bwa/mergedLibrary/`) will have the '`.mLb.`' suffix. diff --git a/modules.json b/modules.json index bf894642f..d2e4dbca4 100644 --- a/modules.json +++ b/modules.json @@ -4,7 +4,7 @@ "repos": { "nf-core/modules": { "bowtie2/align": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" }, "bowtie2/build": { "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" @@ -13,10 +13,10 @@ "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "bwa/mem": { - "git_sha": "950700bcdc0e9a2b6883d40d2c51c6fc435cd714" + "git_sha": "4f5274c3de0c9521f5033893ff61057a74c45ba9" }, "chromap/chromap": { - "git_sha": "dbb46c9b635080b132bab4b8d5b9a14f0d1c22e7" + "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" }, "chromap/index": { "git_sha": "dbb46c9b635080b132bab4b8d5b9a14f0d1c22e7" @@ -40,7 +40,7 @@ "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "fastqc": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + "git_sha": "49b18b1639f4f7104187058866a8fab33332bdfe" }, "gffread": { "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" @@ -55,37 +55,37 @@ "git_sha": "f0800157544a82ae222931764483331a81812012" }, "multiqc": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + "git_sha": "49b18b1639f4f7104187058866a8fab33332bdfe" }, "phantompeakqualtools": { "git_sha": "5e7daa7b96fa9699a52ac8fa3dcbf4291cc6d050" }, "picard/collectmultiplemetrics": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + "git_sha": "49b18b1639f4f7104187058866a8fab33332bdfe" }, "picard/markduplicates": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + "git_sha": "49b18b1639f4f7104187058866a8fab33332bdfe" }, "picard/mergesamfiles": { "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "preseq/lcextrap": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + "git_sha": "7111e571cc5b6069de4673cd6165af680f17b4d7" }, "samtools/flagstat": { - "git_sha": "1ad73f1b2abdea9398680d6d20014838135c9a35" + "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" }, "samtools/idxstats": { - "git_sha": "1ad73f1b2abdea9398680d6d20014838135c9a35" + "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" }, "samtools/index": { - "git_sha": "1ad73f1b2abdea9398680d6d20014838135c9a35" + "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" }, "samtools/sort": { - "git_sha": "1ad73f1b2abdea9398680d6d20014838135c9a35" + "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" }, "samtools/stats": { - "git_sha": "1ad73f1b2abdea9398680d6d20014838135c9a35" + "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" }, "subread/featurecounts": { "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" @@ -97,7 +97,7 @@ "git_sha": "e20e57f90b6787ac9a010a980cf6ea98bd990046" }, "untar": { - "git_sha": "7ec09d0ef4df89617baacc9b2dafcddb7cd4b05a" + "git_sha": "9ae34a01d1747019fd37753ff4cafb05aec35a2b" } } } diff --git a/modules/nf-core/modules/bowtie2/align/main.nf b/modules/nf-core/modules/bowtie2/align/main.nf index 7e8a9659b..44ce76ca0 100644 --- a/modules/nf-core/modules/bowtie2/align/main.nf +++ b/modules/nf-core/modules/bowtie2/align/main.nf @@ -2,10 +2,10 @@ process BOWTIE2_ALIGN { tag "$meta.id" label 'process_high' - conda (params.enable_conda ? 'bioconda::bowtie2=2.4.4 bioconda::samtools=1.14 conda-forge::pigz=2.6' : null) + conda (params.enable_conda ? 'bioconda::bowtie2=2.4.4 bioconda::samtools=1.15.1 conda-forge::pigz=2.6' : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/mulled-v2-ac74a7f02cebcfcc07d8e8d1d750af9c83b4d45a:4d235f41348a00533f18e47c9669f1ecb327f629-0' : - 'quay.io/biocontainers/mulled-v2-ac74a7f02cebcfcc07d8e8d1d750af9c83b4d45a:4d235f41348a00533f18e47c9669f1ecb327f629-0' }" + 'https://depot.galaxyproject.org/singularity/mulled-v2-ac74a7f02cebcfcc07d8e8d1d750af9c83b4d45a:1744f68fe955578c63054b55309e05b41c37a80d-0' : + 'quay.io/biocontainers/mulled-v2-ac74a7f02cebcfcc07d8e8d1d750af9c83b4d45a:1744f68fe955578c63054b55309e05b41c37a80d-0' }" input: tuple val(meta), path(reads) diff --git a/modules/nf-core/modules/bwa/mem/main.nf b/modules/nf-core/modules/bwa/mem/main.nf index 27ea6f42e..f55af9443 100644 --- a/modules/nf-core/modules/bwa/mem/main.nf +++ b/modules/nf-core/modules/bwa/mem/main.nf @@ -2,10 +2,10 @@ process BWA_MEM { tag "$meta.id" label 'process_high' - conda (params.enable_conda ? "bioconda::bwa=0.7.17 bioconda::samtools=1.15" : null) + conda (params.enable_conda ? "bioconda::bwa=0.7.17 bioconda::samtools=1.15.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:c56a3aabc8d64e52d5b9da1e8ecec2031668596d-0' : - 'quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:c56a3aabc8d64e52d5b9da1e8ecec2031668596d-0' }" + 'https://depot.galaxyproject.org/singularity/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:8110a70be2bfe7f75a2ea7f2a89cda4cc7732095-0' : + 'quay.io/biocontainers/mulled-v2-fe8faa35dbf6dc65a0f7f5d4ea12e31a79f73e40:8110a70be2bfe7f75a2ea7f2a89cda4cc7732095-0' }" input: tuple val(meta), path(reads) @@ -23,14 +23,12 @@ process BWA_MEM { def args = task.ext.args ?: '' def args2 = task.ext.args2 ?: '' def prefix = task.ext.prefix ?: "${meta.id}" - def read_group = meta.read_group ? "-R ${meta.read_group}" : "" def samtools_command = sort_bam ? 'sort' : 'view' """ INDEX=`find -L ./ -name "*.amb" | sed 's/.amb//'` bwa mem \\ $args \\ - $read_group \\ -t $task.cpus \\ \$INDEX \\ $reads \\ diff --git a/modules/nf-core/modules/chromap/chromap/main.nf b/modules/nf-core/modules/chromap/chromap/main.nf index bf3d1234c..137f0340c 100644 --- a/modules/nf-core/modules/chromap/chromap/main.nf +++ b/modules/nf-core/modules/chromap/chromap/main.nf @@ -2,10 +2,10 @@ process CHROMAP_CHROMAP { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? "bioconda::chromap=0.2.1 bioconda::samtools=1.15" : null) + conda (params.enable_conda ? "bioconda::chromap=0.2.1 bioconda::samtools=1.15.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:bd74d08a359024829a7aec1638a28607bbcd8a58-0' : - 'quay.io/biocontainers/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:bd74d08a359024829a7aec1638a28607bbcd8a58-0' }" + 'https://depot.galaxyproject.org/singularity/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:963e4fe6a85c548a4018585660aed79780a175d3-0' : + 'quay.io/biocontainers/mulled-v2-1f09f39f20b1c4ee36581dc81cc323c70e661633:963e4fe6a85c548a4018585660aed79780a175d3-0' }" input: tuple val(meta), path(reads) diff --git a/modules/nf-core/modules/fastqc/main.nf b/modules/nf-core/modules/fastqc/main.nf index ed6b8c50b..05730368b 100644 --- a/modules/nf-core/modules/fastqc/main.nf +++ b/modules/nf-core/modules/fastqc/main.nf @@ -44,4 +44,16 @@ process FASTQC { END_VERSIONS """ } + + stub: + def prefix = task.ext.prefix ?: "${meta.id}" + """ + touch ${prefix}.html + touch ${prefix}.zip + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + fastqc: \$( fastqc --version | sed -e "s/FastQC v//g" ) + END_VERSIONS + """ } diff --git a/modules/nf-core/modules/multiqc/main.nf b/modules/nf-core/modules/multiqc/main.nf index 1264aac1e..ae019dbf0 100644 --- a/modules/nf-core/modules/multiqc/main.nf +++ b/modules/nf-core/modules/multiqc/main.nf @@ -28,4 +28,16 @@ process MULTIQC { multiqc: \$( multiqc --version | sed -e "s/multiqc, version //g" ) END_VERSIONS """ + + stub: + """ + touch multiqc_data + touch multiqc_plots + touch multiqc_report.html + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + multiqc: \$( multiqc --version | sed -e "s/multiqc, version //g" ) + END_VERSIONS + """ } diff --git a/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf b/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf index e023ea3c2..340463a86 100644 --- a/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf +++ b/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf @@ -42,4 +42,24 @@ process PICARD_COLLECTMULTIPLEMETRICS { picard: \$(picard CollectMultipleMetrics --version 2>&1 | grep -o 'Version.*' | cut -f2- -d:) END_VERSIONS """ + + stub: + def prefix = task.ext.prefix ?: "${meta.id}" + """ + touch ${prefix}.CollectMultipleMetrics.alignment_summary_metrics + touch ${prefix}.CollectMultipleMetrics.insert_size_metrics + touch ${prefix}.CollectMultipleMetrics.quality_distribution.pdf + touch ${prefix}.CollectMultipleMetrics.base_distribution_by_cycle_metrics + touch ${prefix}.CollectMultipleMetrics.quality_by_cycle_metrics + touch ${prefix}.CollectMultipleMetrics.read_length_histogram.pdf + touch ${prefix}.CollectMultipleMetrics.base_distribution_by_cycle.pdf + touch ${prefix}.CollectMultipleMetrics.quality_by_cycle.pdf + touch ${prefix}.CollectMultipleMetrics.insert_size_histogram.pdf + touch ${prefix}.CollectMultipleMetrics.quality_distribution_metrics + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + picard: \$(echo \$(picard CollectMultipleMetrics --version 2>&1) | grep -o 'Version:.*' | cut -f2- -d:) + END_VERSIONS + """ } diff --git a/modules/nf-core/modules/picard/markduplicates/main.nf b/modules/nf-core/modules/picard/markduplicates/main.nf index 5196b6edf..e754a587e 100644 --- a/modules/nf-core/modules/picard/markduplicates/main.nf +++ b/modules/nf-core/modules/picard/markduplicates/main.nf @@ -42,4 +42,17 @@ process PICARD_MARKDUPLICATES { picard: \$(echo \$(picard MarkDuplicates --version 2>&1) | grep -o 'Version:.*' | cut -f2- -d:) END_VERSIONS """ + + stub: + def prefix = task.ext.prefix ?: "${meta.id}" + """ + touch ${prefix}.bam + touch ${prefix}.bam.bai + touch ${prefix}.MarkDuplicates.metrics.txt + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + picard: \$(echo \$(picard MarkDuplicates --version 2>&1) | grep -o 'Version:.*' | cut -f2- -d:) + END_VERSIONS + """ } diff --git a/modules/nf-core/modules/preseq/lcextrap/main.nf b/modules/nf-core/modules/preseq/lcextrap/main.nf index d6dd19e23..97261557e 100644 --- a/modules/nf-core/modules/preseq/lcextrap/main.nf +++ b/modules/nf-core/modules/preseq/lcextrap/main.nf @@ -5,16 +5,16 @@ process PRESEQ_LCEXTRAP { conda (params.enable_conda ? "bioconda::preseq=3.1.2" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/preseq:3.1.2--h06ef8b0_1' : - 'quay.io/biocontainers/preseq:3.1.2--h06ef8b0_1' }" + 'https://depot.galaxyproject.org/singularity/preseq:3.1.2--h445547b_2': + 'quay.io/biocontainers/preseq:3.1.2--h445547b_2' }" input: tuple val(meta), path(bam) output: - tuple val(meta), path("*.ccurve.txt"), emit: ccurve - tuple val(meta), path("*.log") , emit: log - path "versions.yml" , emit: versions + tuple val(meta), path("*.lc_extrap.txt"), emit: lc_extrap + tuple val(meta), path("*.log") , emit: log + path "versions.yml" , emit: versions when: task.ext.when == null || task.ext.when @@ -28,7 +28,7 @@ process PRESEQ_LCEXTRAP { lc_extrap \\ $args \\ $paired_end \\ - -output ${prefix}.ccurve.txt \\ + -output ${prefix}.lc_extrap.txt \\ $bam cp .command.err ${prefix}.command.log diff --git a/modules/nf-core/modules/preseq/lcextrap/meta.yml b/modules/nf-core/modules/preseq/lcextrap/meta.yml index 0e33df250..f1be05a2f 100644 --- a/modules/nf-core/modules/preseq/lcextrap/meta.yml +++ b/modules/nf-core/modules/preseq/lcextrap/meta.yml @@ -8,8 +8,8 @@ tools: - preseq: description: Software for predicting library complexity and genome coverage in high-throughput sequencing homepage: http://smithlabresearch.org/software/preseq/ - documentation: None - tool_dev_url: None + documentation: http://smithlabresearch.org/wp-content/uploads/manual.pdf + tool_dev_url: https://github.com/smithlabcode/preseq doi: "" licence: ["GPL"] @@ -34,10 +34,10 @@ output: type: file description: File containing software versions pattern: "versions.yml" - - ccurve: + - lc_extrap: type: file description: File containing output of Preseq lcextrap - pattern: "*.{ccurve.txt}" + pattern: "*.{lc_extrap.txt}" - log: type: file description: Log file containing stderr produced by Preseq @@ -45,3 +45,4 @@ output: authors: - "@drpatelh" + - "@Emiller88" diff --git a/modules/nf-core/modules/samtools/idxstats/main.nf b/modules/nf-core/modules/samtools/idxstats/main.nf index 7d5cee172..a49ff35f9 100644 --- a/modules/nf-core/modules/samtools/idxstats/main.nf +++ b/modules/nf-core/modules/samtools/idxstats/main.nf @@ -2,10 +2,10 @@ process SAMTOOLS_IDXSTATS { tag "$meta.id" label 'process_low' - conda (params.enable_conda ? "bioconda::samtools=1.15" : null) + conda (params.enable_conda ? "bioconda::samtools=1.15.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/samtools:1.15--h1170115_1' : - 'quay.io/biocontainers/samtools:1.15--h1170115_1' }" + 'https://depot.galaxyproject.org/singularity/samtools:1.15.1--h1170115_0' : + 'quay.io/biocontainers/samtools:1.15.1--h1170115_0' }" input: tuple val(meta), path(bam), path(bai) diff --git a/modules/nf-core/modules/samtools/index/main.nf b/modules/nf-core/modules/samtools/index/main.nf index e41cdcc88..e04e63e85 100644 --- a/modules/nf-core/modules/samtools/index/main.nf +++ b/modules/nf-core/modules/samtools/index/main.nf @@ -2,10 +2,10 @@ process SAMTOOLS_INDEX { tag "$meta.id" label 'process_low' - conda (params.enable_conda ? "bioconda::samtools=1.15" : null) + conda (params.enable_conda ? "bioconda::samtools=1.15.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/samtools:1.15--h1170115_1' : - 'quay.io/biocontainers/samtools:1.15--h1170115_1' }" + 'https://depot.galaxyproject.org/singularity/samtools:1.15.1--h1170115_0' : + 'quay.io/biocontainers/samtools:1.15.1--h1170115_0' }" input: tuple val(meta), path(input) @@ -33,4 +33,16 @@ process SAMTOOLS_INDEX { samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS """ + + stub: + """ + touch ${input}.bai + touch ${input}.crai + touch ${input}.csi + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + END_VERSIONS + """ } diff --git a/modules/nf-core/modules/samtools/sort/main.nf b/modules/nf-core/modules/samtools/sort/main.nf index 0e2de8baa..b4fc1cbe9 100644 --- a/modules/nf-core/modules/samtools/sort/main.nf +++ b/modules/nf-core/modules/samtools/sort/main.nf @@ -2,10 +2,10 @@ process SAMTOOLS_SORT { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? "bioconda::samtools=1.15" : null) + conda (params.enable_conda ? "bioconda::samtools=1.15.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/samtools:1.15--h1170115_1' : - 'quay.io/biocontainers/samtools:1.15--h1170115_1' }" + 'https://depot.galaxyproject.org/singularity/samtools:1.15.1--h1170115_0' : + 'quay.io/biocontainers/samtools:1.15.1--h1170115_0' }" input: tuple val(meta), path(bam) @@ -28,4 +28,15 @@ process SAMTOOLS_SORT { samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS """ + + stub: + def prefix = task.ext.prefix ?: "${meta.id}" + """ + touch ${prefix}.bam + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + END_VERSIONS + """ } diff --git a/modules/nf-core/modules/samtools/stats/main.nf b/modules/nf-core/modules/samtools/stats/main.nf index 6efc9d9a5..bbdc3240d 100644 --- a/modules/nf-core/modules/samtools/stats/main.nf +++ b/modules/nf-core/modules/samtools/stats/main.nf @@ -2,10 +2,10 @@ process SAMTOOLS_STATS { tag "$meta.id" label 'process_low' - conda (params.enable_conda ? "bioconda::samtools=1.15" : null) + conda (params.enable_conda ? "bioconda::samtools=1.15.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/samtools:1.15--h1170115_1' : - 'quay.io/biocontainers/samtools:1.15--h1170115_1' }" + 'https://depot.galaxyproject.org/singularity/samtools:1.15.1--h1170115_0' : + 'quay.io/biocontainers/samtools:1.15.1--h1170115_0' }" input: tuple val(meta), path(input), path(input_index) @@ -34,4 +34,15 @@ process SAMTOOLS_STATS { samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') END_VERSIONS """ + + stub: + def prefix = task.ext.prefix ?: "${meta.id}" + """ + touch ${input}.stats + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + END_VERSIONS + """ } diff --git a/modules/nf-core/modules/untar/main.nf b/modules/nf-core/modules/untar/main.nf index bbae948aa..bbfa0bfe7 100644 --- a/modules/nf-core/modules/untar/main.nf +++ b/modules/nf-core/modules/untar/main.nf @@ -2,25 +2,25 @@ process UNTAR { tag "$archive" label 'process_low' - conda (params.enable_conda ? "conda-forge::tar=1.32" : null) + conda (params.enable_conda ? "conda-forge::tar=1.34" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://containers.biocontainers.pro/s3/SingImgsRepo/biocontainers/v1.2.0_cv1/biocontainers_v1.2.0_cv1.img' : - 'biocontainers/biocontainers:v1.2.0_cv1' }" + 'https://containers.biocontainers.pro/s3/SingImgsRepo/biocontainers/v1.2.0_cv2/biocontainers_v1.2.0_cv2.img' : + 'biocontainers/biocontainers:v1.2.0_cv2' }" input: - path archive + tuple val(meta), path(archive) output: - path "$untar" , emit: untar - path "versions.yml", emit: versions + tuple val(meta), path("$untar"), emit: untar + path "versions.yml" , emit: versions when: task.ext.when == null || task.ext.when script: - def args = task.ext.args ?: '' + def args = task.ext.args ?: '' def args2 = task.ext.args2 ?: '' - untar = archive.toString() - '.tar.gz' + untar = archive.toString() - '.tar.gz' """ tar \\ -xzvf \\ @@ -33,4 +33,15 @@ process UNTAR { untar: \$(echo \$(tar --version 2>&1) | sed 's/^.*(GNU tar) //; s/ Copyright.*\$//') END_VERSIONS """ + + stub: + untar = archive.toString() - '.tar.gz' + """ + touch $untar + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + untar: \$(echo \$(tar --version 2>&1) | sed 's/^.*(GNU tar) //; s/ Copyright.*\$//') + END_VERSIONS + """ } diff --git a/modules/nf-core/modules/untar/meta.yml b/modules/nf-core/modules/untar/meta.yml index e877a97c1..d426919bd 100644 --- a/modules/nf-core/modules/untar/meta.yml +++ b/modules/nf-core/modules/untar/meta.yml @@ -10,11 +10,21 @@ tools: documentation: https://www.gnu.org/software/tar/manual/ licence: ["GPL-3.0-or-later"] input: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] - archive: type: file description: File to be untar pattern: "*.{tar}.{gz}" output: + - meta: + type: map + description: | + Groovy Map containing sample information + e.g. [ id:'test', single_end:false ] - untar: type: file description: diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index e271da03d..33aa189ed 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -130,7 +130,7 @@ workflow PREPARE_GENOME { if (prepare_tool_index == 'bwa') { if (params.bwa_index) { if (params.bwa_index.endsWith('.tar.gz')) { - ch_bwa_index = UNTAR_BWA_INDEX ( params.bwa_index ).untar + ch_bwa_index = UNTAR_BWA_INDEX ( [], params.bwa_index ).untar.map{it -> it[1]} ch_versions = ch_versions.mix(UNTAR_BWA_INDEX.out.versions) } else { ch_bwa_index = file(params.bwa_index) @@ -148,7 +148,7 @@ workflow PREPARE_GENOME { if (prepare_tool_index == 'bowtie2') { if (params.bowtie2_index) { if (params.bowtie2_index.endsWith('.tar.gz')) { - ch_bowtie2_index = UNTAR_BOWTIE2_INDEX ( params.bowtie2_index ).untar + ch_bowtie2_index = UNTAR_BOWTIE2_INDEX ( [], params.bowtie2_index ).untar.map{it -> it[1]} ch_versions = ch_versions.mix(UNTAR_BOWTIE2_INDEX.out.versions) } else { ch_bowtie2_index = file(params.bowtie2_index) @@ -184,7 +184,7 @@ workflow PREPARE_GENOME { if (prepare_tool_index == 'star') { if (params.star_index) { if (params.star_index.endsWith('.tar.gz')) { - ch_star_index = UNTAR_STAR_INDEX ( params.star_index ).untar + ch_star_index = UNTAR_STAR_INDEX ( [], params.star_index ).untar.map{it -> it[1]} ch_versions = ch_versions.mix(UNTAR_STAR_INDEX.out.versions) } else { ch_star_index = file(params.star_index) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index f5960e9d3..625632528 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -291,7 +291,7 @@ workflow CHIPSEQ { PRESEQ_LCEXTRAP ( FILTER_BAM_BAMTOOLS.out.bam ) - ch_preseq_multiqc = PRESEQ_LCEXTRAP.out.ccurve + ch_preseq_multiqc = PRESEQ_LCEXTRAP.out.lc_extrap ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions.first()) } From 938d0342d0bfbede0e4dcfe5c91313c0a749520e Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 21 Apr 2022 08:40:33 +0200 Subject: [PATCH 377/538] Update samtools flagstat --- modules/nf-core/modules/samtools/flagstat/main.nf | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/modules/nf-core/modules/samtools/flagstat/main.nf b/modules/nf-core/modules/samtools/flagstat/main.nf index 9e3440acd..b87b21081 100644 --- a/modules/nf-core/modules/samtools/flagstat/main.nf +++ b/modules/nf-core/modules/samtools/flagstat/main.nf @@ -2,10 +2,10 @@ process SAMTOOLS_FLAGSTAT { tag "$meta.id" label 'process_low' - conda (params.enable_conda ? "bioconda::samtools=1.15" : null) + conda (params.enable_conda ? "bioconda::samtools=1.15.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/samtools:1.15--h1170115_1' : - 'quay.io/biocontainers/samtools:1.15--h1170115_1' }" + 'https://depot.galaxyproject.org/singularity/samtools:1.15.1--h1170115_0' : + 'quay.io/biocontainers/samtools:1.15.1--h1170115_0' }" input: tuple val(meta), path(bam), path(bai) From e9f4e092ed4507340a35a08ad86a59e14ede357a Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 21 Apr 2022 08:40:55 +0200 Subject: [PATCH 378/538] Update bam_filter mulled container --- modules/local/bam_filter.nf | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/modules/local/bam_filter.nf b/modules/local/bam_filter.nf index 6b31709df..ff07c084b 100644 --- a/modules/local/bam_filter.nf +++ b/modules/local/bam_filter.nf @@ -5,10 +5,10 @@ process BAM_FILTER { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? "bioconda::bamtools=2.4.0 bioconda::samtools=1.4.1" : null) + conda (params.enable_conda ? "bioconda::bamtools=2.5.2 bioconda::samtools=1.15.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/mulled-v2-0560a8046fc82aa4338588eca29ff18edab2c5aa:fc33176431a4b9ef3213640937e641d731db04f1-0' : - 'quay.io/biocontainers/mulled-v2-0560a8046fc82aa4338588eca29ff18edab2c5aa:fc33176431a4b9ef3213640937e641d731db04f1-0' }" + 'https://depot.galaxyproject.org/singularity/mulled-v2-0560a8046fc82aa4338588eca29ff18edab2c5aa:5687a7da26983502d0a8a9a6b05ed727c740ddc4-0' : + 'quay.io/biocontainers/mulled-v2-0560a8046fc82aa4338588eca29ff18edab2c5aa:5687a7da26983502d0a8a9a6b05ed727c740ddc4-0' }" input: tuple val(meta), path(bam), path(bai) From 715ff243c5c95bbfeee15d0c711004da6fa15793 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 21 Apr 2022 10:01:37 +0200 Subject: [PATCH 379/538] Update tools versions in changelog --- CHANGELOG.md | 48 ++++++++++++++++++++++++------------------------ 1 file changed, 24 insertions(+), 24 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 53ca266b4..c84a38edb 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -39,30 +39,30 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 Note, since the pipeline is now using Nextflow DSL2, each process will be run with its own [Biocontainer](https://biocontainers.pro/#/registry). This means that on occasion it is entirely possible for the pipeline to be using different versions of the same tool. However, the overall software dependency changes compared to the last release have been listed below for reference. - +| Dependency | Old version | New version | +|-----------------------------|-------------|-------------| +| `samtools` | 1.10 | 1.15.1 | +| `picard` | 2.23.1 | 2.26.10 | +| `picard` | 2.23.1 | 2.26.10 | +| `bamtools` | 2.5.1 | 2.5.2 | +| `pysam` | 0.15.3 | 0.16.0.1 | +| `bedtools` | 2.29.2 | 2.30.0 | +| `ucsc-bedgraphtobigwig` | 357 | 377 | +| `deeptools` | 3.4.3 | 3.5.1 | +| `pigz` | 2.3.4 | 2.6 | +| `preseq` | 2.0.3 | 3.1.2 | +| `multiqc` | 1.9 | 1.12 | +| `r-base` | 3.6.1 | 4.0.3 | +| `r-ggplot2` | 3.3.2 | 3.3.3 | +| `bioconductor-deseq2` | 1.26.0 | 1.28.0 | +| `r-optparse` | - | 1.7.1 | +| `chromap` | - | 0.2.1 | +| `bowtie2` | - | 2.4.4 | +| `star` | - | 2.6.1d | +| `r-tidyr` | - | - | +| `r-lattice` | - | - | +| `r-xfun` | - | - | +| `bioconductor-vsn` | - | - | > **NB:** Dependency has been **updated** if both old and new version information is present. > **NB:** Dependency has been **added** if just the new version information is present. From d0f6680e96c8faea670dbe3d5e2e233ef38c40e9 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 21 Apr 2022 11:29:38 +0200 Subject: [PATCH 380/538] Make prettier happy --- CHANGELOG.md | 48 ++++++++++++++++++++++++------------------------ 1 file changed, 24 insertions(+), 24 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index c84a38edb..bfc2befaf 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -39,30 +39,30 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 Note, since the pipeline is now using Nextflow DSL2, each process will be run with its own [Biocontainer](https://biocontainers.pro/#/registry). This means that on occasion it is entirely possible for the pipeline to be using different versions of the same tool. However, the overall software dependency changes compared to the last release have been listed below for reference. -| Dependency | Old version | New version | -|-----------------------------|-------------|-------------| -| `samtools` | 1.10 | 1.15.1 | -| `picard` | 2.23.1 | 2.26.10 | -| `picard` | 2.23.1 | 2.26.10 | -| `bamtools` | 2.5.1 | 2.5.2 | -| `pysam` | 0.15.3 | 0.16.0.1 | -| `bedtools` | 2.29.2 | 2.30.0 | -| `ucsc-bedgraphtobigwig` | 357 | 377 | -| `deeptools` | 3.4.3 | 3.5.1 | -| `pigz` | 2.3.4 | 2.6 | -| `preseq` | 2.0.3 | 3.1.2 | -| `multiqc` | 1.9 | 1.12 | -| `r-base` | 3.6.1 | 4.0.3 | -| `r-ggplot2` | 3.3.2 | 3.3.3 | -| `bioconductor-deseq2` | 1.26.0 | 1.28.0 | -| `r-optparse` | - | 1.7.1 | -| `chromap` | - | 0.2.1 | -| `bowtie2` | - | 2.4.4 | -| `star` | - | 2.6.1d | -| `r-tidyr` | - | - | -| `r-lattice` | - | - | -| `r-xfun` | - | - | -| `bioconductor-vsn` | - | - | +| Dependency | Old version | New version | +| ----------------------- | ----------- | ----------- | +| `samtools` | 1.10 | 1.15.1 | +| `picard` | 2.23.1 | 2.26.10 | +| `picard` | 2.23.1 | 2.26.10 | +| `bamtools` | 2.5.1 | 2.5.2 | +| `pysam` | 0.15.3 | 0.16.0.1 | +| `bedtools` | 2.29.2 | 2.30.0 | +| `ucsc-bedgraphtobigwig` | 357 | 377 | +| `deeptools` | 3.4.3 | 3.5.1 | +| `pigz` | 2.3.4 | 2.6 | +| `preseq` | 2.0.3 | 3.1.2 | +| `multiqc` | 1.9 | 1.12 | +| `r-base` | 3.6.1 | 4.0.3 | +| `r-ggplot2` | 3.3.2 | 3.3.3 | +| `bioconductor-deseq2` | 1.26.0 | 1.28.0 | +| `r-optparse` | - | 1.7.1 | +| `chromap` | - | 0.2.1 | +| `bowtie2` | - | 2.4.4 | +| `star` | - | 2.6.1d | +| `r-tidyr` | - | - | +| `r-lattice` | - | - | +| `r-xfun` | - | - | +| `bioconductor-vsn` | - | - | > **NB:** Dependency has been **updated** if both old and new version information is present. > **NB:** Dependency has been **added** if just the new version information is present. From 2f556a19747d87a711d72aa529b9c8432d0cb73c Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 22 Apr 2022 10:28:16 +0200 Subject: [PATCH 381/538] Update FRIP_SCORE mulled container --- modules/local/frip_score.nf | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/modules/local/frip_score.nf b/modules/local/frip_score.nf index 6a364c58c..e8fdbcc91 100644 --- a/modules/local/frip_score.nf +++ b/modules/local/frip_score.nf @@ -2,10 +2,10 @@ process FRIP_SCORE { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? "bioconda::bedtools=2.30.0 bioconda::samtools=1.9" : null) + conda (params.enable_conda ? "bioconda::bedtools=2.30.0 bioconda::samtools=1.15.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/mulled-v2-8186960447c5cb2faa697666dc1e6d919ad23f3e:2200fd433290bb814a952b2fd7cc8013499de840-': - 'quay.io/biocontainers/mulled-v2-8186960447c5cb2faa697666dc1e6d919ad23f3e:2200fd433290bb814a952b2fd7cc8013499de840-0' }" + 'https://depot.galaxyproject.org/singularity/mulled-v2-8186960447c5cb2faa697666dc1e6d919ad23f3e:3127fcae6b6bdaf8181e21a26ae61231030a9fcb-0': + 'quay.io/biocontainers/mulled-v2-8186960447c5cb2faa697666dc1e6d919ad23f3e:3127fcae6b6bdaf8181e21a26ae61231030a9fcb-0' }" input: tuple val(meta), path(bam), path(peak) From d3e6824a104fde17d1e0cacc672b82e4c981829b Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 22 Apr 2022 13:24:48 +0200 Subject: [PATCH 382/538] Update bam_remove_orphans mulled container --- CHANGELOG.md | 2 +- modules/local/bam_remove_orphans.nf | 6 +++--- 2 files changed, 4 insertions(+), 4 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index bfc2befaf..9fda27321 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -45,7 +45,7 @@ Note, since the pipeline is now using Nextflow DSL2, each process will be run wi | `picard` | 2.23.1 | 2.26.10 | | `picard` | 2.23.1 | 2.26.10 | | `bamtools` | 2.5.1 | 2.5.2 | -| `pysam` | 0.15.3 | 0.16.0.1 | +| `pysam` | 0.15.3 | 0.19.0 | | `bedtools` | 2.29.2 | 2.30.0 | | `ucsc-bedgraphtobigwig` | 357 | 377 | | `deeptools` | 3.4.3 | 3.5.1 | diff --git a/modules/local/bam_remove_orphans.nf b/modules/local/bam_remove_orphans.nf index 99ff4f932..21ffc73a9 100644 --- a/modules/local/bam_remove_orphans.nf +++ b/modules/local/bam_remove_orphans.nf @@ -5,10 +5,10 @@ process BAM_REMOVE_ORPHANS { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? "bioconda::pysam=0.16.0.1 bioconda::samtools=1.13" : null) + conda (params.enable_conda ? "bioconda::pysam=0.19.0 bioconda::samtools=1.15.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/mulled-v2-57736af1eb98c01010848572c9fec9fff6ffaafd:980645707aa512b63b32c44c35888ac1dab126dd-0' : - 'quay.io/biocontainers/mulled-v2-57736af1eb98c01010848572c9fec9fff6ffaafd:980645707aa512b63b32c44c35888ac1dab126dd-0' }" + 'https://depot.galaxyproject.org/singularity/mulled-v2-57736af1eb98c01010848572c9fec9fff6ffaafd:402e865b8f6af2f3e58c6fc8d57127ff0144b2c7-0' : + 'quay.io/biocontainers/mulled-v2-57736af1eb98c01010848572c9fec9fff6ffaafd:402e865b8f6af2f3e58c6fc8d57127ff0144b2c7-0' }" input: tuple val(meta), path(bam) From dd79c1ceee7d07eae07057fae2a546d7c2b9158d Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 22 Apr 2022 16:55:43 +0200 Subject: [PATCH 383/538] Update modules --- conf/modules.config | 1 + modules.json | 6 +++--- modules/nf-core/modules/gunzip/main.nf | 4 ++-- modules/nf-core/modules/phantompeakqualtools/main.nf | 2 +- modules/nf-core/modules/untar/main.nf | 6 +++--- 5 files changed, 10 insertions(+), 9 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 4d0988886..5a94f3374 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -374,6 +374,7 @@ process { } withName: 'PHANTOMPEAKQUALTOOLS' { + ext.args = { "-p=$task.cpus" } ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/phantompeakqualtools" }, diff --git a/modules.json b/modules.json index d2e4dbca4..7ec5dd8ef 100644 --- a/modules.json +++ b/modules.json @@ -46,7 +46,7 @@ "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "gunzip": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + "git_sha": "9aadd9a6d3f5964476582319b3a1c54a3e3fe7c9" }, "homer/annotatepeaks": { "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" @@ -58,7 +58,7 @@ "git_sha": "49b18b1639f4f7104187058866a8fab33332bdfe" }, "phantompeakqualtools": { - "git_sha": "5e7daa7b96fa9699a52ac8fa3dcbf4291cc6d050" + "git_sha": "b3e56c83c683111d0d3edfa2821454d6132b6b66" }, "picard/collectmultiplemetrics": { "git_sha": "49b18b1639f4f7104187058866a8fab33332bdfe" @@ -97,7 +97,7 @@ "git_sha": "e20e57f90b6787ac9a010a980cf6ea98bd990046" }, "untar": { - "git_sha": "9ae34a01d1747019fd37753ff4cafb05aec35a2b" + "git_sha": "9aadd9a6d3f5964476582319b3a1c54a3e3fe7c9" } } } diff --git a/modules/nf-core/modules/gunzip/main.nf b/modules/nf-core/modules/gunzip/main.nf index 9d4b06669..61bf1afa5 100644 --- a/modules/nf-core/modules/gunzip/main.nf +++ b/modules/nf-core/modules/gunzip/main.nf @@ -4,8 +4,8 @@ process GUNZIP { conda (params.enable_conda ? "conda-forge::sed=4.7" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://containers.biocontainers.pro/s3/SingImgsRepo/biocontainers/v1.2.0_cv1/biocontainers_v1.2.0_cv1.img' : - 'biocontainers/biocontainers:v1.2.0_cv1' }" + 'https://depot.galaxyproject.org/singularity/ubuntu:20.04' : + 'ubuntu:20.04' }" input: tuple val(meta), path(archive) diff --git a/modules/nf-core/modules/phantompeakqualtools/main.nf b/modules/nf-core/modules/phantompeakqualtools/main.nf index f584cb65d..0362b2e74 100644 --- a/modules/nf-core/modules/phantompeakqualtools/main.nf +++ b/modules/nf-core/modules/phantompeakqualtools/main.nf @@ -26,7 +26,7 @@ process PHANTOMPEAKQUALTOOLS { def prefix = task.ext.prefix ?: "${meta.id}" """ RUN_SPP=`which run_spp.R` - Rscript $args -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" -p=$task.cpus + Rscript $args -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" cat <<-END_VERSIONS > versions.yml "${task.process}": diff --git a/modules/nf-core/modules/untar/main.nf b/modules/nf-core/modules/untar/main.nf index bbfa0bfe7..058d17644 100644 --- a/modules/nf-core/modules/untar/main.nf +++ b/modules/nf-core/modules/untar/main.nf @@ -2,10 +2,10 @@ process UNTAR { tag "$archive" label 'process_low' - conda (params.enable_conda ? "conda-forge::tar=1.34" : null) + conda (params.enable_conda ? "conda-forge::sed=4.7" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://containers.biocontainers.pro/s3/SingImgsRepo/biocontainers/v1.2.0_cv2/biocontainers_v1.2.0_cv2.img' : - 'biocontainers/biocontainers:v1.2.0_cv2' }" + 'https://depot.galaxyproject.org/singularity/ubuntu:20.04' : + 'ubuntu:20.04' }" input: tuple val(meta), path(archive) From 503b95b81a968adf83e6a90ad0d1e5238454cc2c Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 26 Apr 2022 09:56:33 +0200 Subject: [PATCH 384/538] Update phantompeakqualtools module --- conf/modules.config | 2 +- modules.json | 2 +- modules/nf-core/modules/phantompeakqualtools/main.nf | 5 +++-- 3 files changed, 5 insertions(+), 4 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 5a94f3374..37672b73f 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -374,7 +374,7 @@ process { } withName: 'PHANTOMPEAKQUALTOOLS' { - ext.args = { "-p=$task.cpus" } + ext.args2 = { "-p=$task.cpus" } ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/phantompeakqualtools" }, diff --git a/modules.json b/modules.json index 7ec5dd8ef..d6cb9f038 100644 --- a/modules.json +++ b/modules.json @@ -58,7 +58,7 @@ "git_sha": "49b18b1639f4f7104187058866a8fab33332bdfe" }, "phantompeakqualtools": { - "git_sha": "b3e56c83c683111d0d3edfa2821454d6132b6b66" + "git_sha": "6a46e7cf117bbae41bca9b4c7ff7a77794df16ec" }, "picard/collectmultiplemetrics": { "git_sha": "49b18b1639f4f7104187058866a8fab33332bdfe" diff --git a/modules/nf-core/modules/phantompeakqualtools/main.nf b/modules/nf-core/modules/phantompeakqualtools/main.nf index 0362b2e74..d8f733425 100644 --- a/modules/nf-core/modules/phantompeakqualtools/main.nf +++ b/modules/nf-core/modules/phantompeakqualtools/main.nf @@ -22,11 +22,12 @@ process PHANTOMPEAKQUALTOOLS { task.ext.when == null || task.ext.when script: - def args = task.ext.args ?: '' + def args = task.ext.args ?: '' + def args2 = task.ext.args2 ?: '' def prefix = task.ext.prefix ?: "${meta.id}" """ RUN_SPP=`which run_spp.R` - Rscript $args -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" + Rscript $args -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" $args2 cat <<-END_VERSIONS > versions.yml "${task.process}": From 9ffb7a0a1af526870f4f3ceabf984029fbf5b90b Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 28 Apr 2022 22:36:47 +0200 Subject: [PATCH 385/538] Update custom_getchromsizes module --- modules/nf-core/modules/custom/getchromsizes/main.nf | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/modules/nf-core/modules/custom/getchromsizes/main.nf b/modules/nf-core/modules/custom/getchromsizes/main.nf index bbcfa9bec..0eabf3a4c 100644 --- a/modules/nf-core/modules/custom/getchromsizes/main.nf +++ b/modules/nf-core/modules/custom/getchromsizes/main.nf @@ -2,10 +2,10 @@ process CUSTOM_GETCHROMSIZES { tag "$fasta" label 'process_low' - conda (params.enable_conda ? "bioconda::samtools=1.15" : null) + conda (params.enable_conda ? "bioconda::samtools=1.15.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/samtools:1.15--h1170115_1' : - 'quay.io/biocontainers/samtools:1.15--h1170115_1' }" + 'https://depot.galaxyproject.org/singularity/samtools:1.15.1--h1170115_0' : + 'quay.io/biocontainers/samtools:1.15.1--h1170115_0' }" input: path fasta From 2ff1476b33cb18524de60ec31e36b147c8a6a6aa Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 2 May 2022 12:29:19 +0200 Subject: [PATCH 386/538] Update modules picard and trimgalore modules --- modules.json | 10 +++++----- .../modules/picard/collectmultiplemetrics/main.nf | 12 ++++++------ .../nf-core/modules/picard/markduplicates/main.nf | 12 ++++++------ .../nf-core/modules/picard/mergesamfiles/main.nf | 10 +++++----- modules/nf-core/modules/trimgalore/main.nf | 13 ++++++++----- modules/nf-core/modules/trimgalore/meta.yml | 5 +++++ 6 files changed, 35 insertions(+), 27 deletions(-) diff --git a/modules.json b/modules.json index d6cb9f038..9a2a18374 100644 --- a/modules.json +++ b/modules.json @@ -25,7 +25,7 @@ "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "custom/getchromsizes": { - "git_sha": "950700bcdc0e9a2b6883d40d2c51c6fc435cd714" + "git_sha": "213403187932dbbdd936a04474cc8cd8abae7a08" }, "deeptools/computematrix": { "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" @@ -61,13 +61,13 @@ "git_sha": "6a46e7cf117bbae41bca9b4c7ff7a77794df16ec" }, "picard/collectmultiplemetrics": { - "git_sha": "49b18b1639f4f7104187058866a8fab33332bdfe" + "git_sha": "00467ac64affbbc17b255762f10a6c8fa362aabc" }, "picard/markduplicates": { - "git_sha": "49b18b1639f4f7104187058866a8fab33332bdfe" + "git_sha": "20ebb89ff97a2665106be9cace5ccb9aa4eed1be" }, "picard/mergesamfiles": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + "git_sha": "20ebb89ff97a2665106be9cace5ccb9aa4eed1be" }, "preseq/lcextrap": { "git_sha": "7111e571cc5b6069de4673cd6165af680f17b4d7" @@ -91,7 +91,7 @@ "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "trimgalore": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + "git_sha": "85ec13ff1fc2196c5a507ea497de468101baabed" }, "ucsc/bedgraphtobigwig": { "git_sha": "e20e57f90b6787ac9a010a980cf6ea98bd990046" diff --git a/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf b/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf index 340463a86..a653b5490 100644 --- a/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf +++ b/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf @@ -2,10 +2,10 @@ process PICARD_COLLECTMULTIPLEMETRICS { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? "bioconda::picard=2.26.10" : null) + conda (params.enable_conda ? "bioconda::picard=2.27.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/picard:2.26.10--hdfd78af_0' : - 'quay.io/biocontainers/picard:2.26.10--hdfd78af_0' }" + 'https://depot.galaxyproject.org/singularity/picard:2.27.1--hdfd78af_0' : + 'quay.io/biocontainers/picard:2.27.1--hdfd78af_0' }" input: tuple val(meta), path(bam) @@ -33,9 +33,9 @@ process PICARD_COLLECTMULTIPLEMETRICS { -Xmx${avail_mem}g \\ CollectMultipleMetrics \\ $args \\ - INPUT=$bam \\ - OUTPUT=${prefix}.CollectMultipleMetrics \\ - REFERENCE_SEQUENCE=$fasta + --INPUT $bam \\ + --OUTPUT ${prefix}.CollectMultipleMetrics \\ + --REFERENCE_SEQUENCE $fasta cat <<-END_VERSIONS > versions.yml "${task.process}": diff --git a/modules/nf-core/modules/picard/markduplicates/main.nf b/modules/nf-core/modules/picard/markduplicates/main.nf index e754a587e..1565c6478 100644 --- a/modules/nf-core/modules/picard/markduplicates/main.nf +++ b/modules/nf-core/modules/picard/markduplicates/main.nf @@ -2,10 +2,10 @@ process PICARD_MARKDUPLICATES { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? "bioconda::picard=2.26.10" : null) + conda (params.enable_conda ? "bioconda::picard=2.27.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/picard:2.26.10--hdfd78af_0' : - 'quay.io/biocontainers/picard:2.26.10--hdfd78af_0' }" + 'https://depot.galaxyproject.org/singularity/picard:2.27.1--hdfd78af_0' : + 'quay.io/biocontainers/picard:2.27.1--hdfd78af_0' }" input: tuple val(meta), path(bam) @@ -33,9 +33,9 @@ process PICARD_MARKDUPLICATES { -Xmx${avail_mem}g \\ MarkDuplicates \\ $args \\ - I=$bam \\ - O=${prefix}.bam \\ - M=${prefix}.MarkDuplicates.metrics.txt + --INPUT $bam \\ + --OUTPUT ${prefix}.bam \\ + --METRICS_FILE ${prefix}.MarkDuplicates.metrics.txt cat <<-END_VERSIONS > versions.yml "${task.process}": diff --git a/modules/nf-core/modules/picard/mergesamfiles/main.nf b/modules/nf-core/modules/picard/mergesamfiles/main.nf index ef5c39807..1e32c63a6 100644 --- a/modules/nf-core/modules/picard/mergesamfiles/main.nf +++ b/modules/nf-core/modules/picard/mergesamfiles/main.nf @@ -2,10 +2,10 @@ process PICARD_MERGESAMFILES { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? "bioconda::picard=2.26.10" : null) + conda (params.enable_conda ? "bioconda::picard=2.27.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/picard:2.26.10--hdfd78af_0' : - 'quay.io/biocontainers/picard:2.26.10--hdfd78af_0' }" + 'https://depot.galaxyproject.org/singularity/picard:2.27.1--hdfd78af_0' : + 'quay.io/biocontainers/picard:2.27.1--hdfd78af_0' }" input: tuple val(meta), path(bams) @@ -33,8 +33,8 @@ process PICARD_MERGESAMFILES { -Xmx${avail_mem}g \\ MergeSamFiles \\ $args \\ - ${'INPUT='+bam_files.join(' INPUT=')} \\ - OUTPUT=${prefix}.bam + ${'--INPUT '+bam_files.join(' --INPUT ')} \\ + --OUTPUT ${prefix}.bam cat <<-END_VERSIONS > versions.yml "${task.process}": picard: \$( echo \$(picard MergeSamFiles --version 2>&1) | grep -o 'Version:.*' | cut -f2- -d:) diff --git a/modules/nf-core/modules/trimgalore/main.nf b/modules/nf-core/modules/trimgalore/main.nf index 9487c7990..3a3fca904 100644 --- a/modules/nf-core/modules/trimgalore/main.nf +++ b/modules/nf-core/modules/trimgalore/main.nf @@ -11,12 +11,13 @@ process TRIMGALORE { tuple val(meta), path(reads) output: - tuple val(meta), path("*.fq.gz") , emit: reads - tuple val(meta), path("*report.txt"), emit: log - path "versions.yml" , emit: versions + tuple val(meta), path("*{trimmed,val}*.fq.gz"), emit: reads + tuple val(meta), path("*report.txt") , emit: log + path "versions.yml" , emit: versions - tuple val(meta), path("*.html"), emit: html optional true - tuple val(meta), path("*.zip") , emit: zip optional true + tuple val(meta), path("*unpaired*.fq.gz") , emit: unpaired, optional: true + tuple val(meta), path("*.html") , emit: html , optional: true + tuple val(meta), path("*.zip") , emit: zip , optional: true when: task.ext.when == null || task.ext.when @@ -52,6 +53,7 @@ process TRIMGALORE { $c_r1 \\ $tpc_r1 \\ ${prefix}.fastq.gz + cat <<-END_VERSIONS > versions.yml "${task.process}": trimgalore: \$(echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//') @@ -73,6 +75,7 @@ process TRIMGALORE { $tpc_r2 \\ ${prefix}_1.fastq.gz \\ ${prefix}_2.fastq.gz + cat <<-END_VERSIONS > versions.yml "${task.process}": trimgalore: \$(echo \$(trim_galore --version 2>&1) | sed 's/^.*version //; s/Last.*\$//') diff --git a/modules/nf-core/modules/trimgalore/meta.yml b/modules/nf-core/modules/trimgalore/meta.yml index e99a88334..439f566df 100644 --- a/modules/nf-core/modules/trimgalore/meta.yml +++ b/modules/nf-core/modules/trimgalore/meta.yml @@ -37,6 +37,11 @@ output: List of input adapter trimmed FastQ files of size 1 and 2 for single-end and paired-end data, respectively. pattern: "*.{fq.gz}" + - unpaired: + type: file + description: | + FastQ files containing unpaired reads from read 1 or read 2 + pattern: "*unpaired*.fq.gz" - html: type: file description: FastQC report (optional) From d5d66470fd5559f01519fb665b627d33e98a4d97 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 2 May 2022 22:39:32 +0200 Subject: [PATCH 387/538] Update picard arguments --- conf/modules.config | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index 37672b73f..c44a6dfd1 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -292,7 +292,7 @@ process { } withName: '.*:MARK_DUPLICATES_PICARD:PICARD_MARKDUPLICATES' { - ext.args = 'ASSUME_SORTED=true REMOVE_DUPLICATES=false VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' + ext.args = '--ASSUME_SORTED true --REMOVE_DUPLICATES false --VALIDATION_STRINGENCY LENIENT --TMP_DIR tmp' ext.prefix = { "${meta.id}.mLb.mkD.sorted" } publishDir = [ [ From 1c65c16edeb9a092f957e09180acdfe7119f6e6a Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 3 May 2022 00:11:32 +0200 Subject: [PATCH 388/538] Is good to save changes before commiting --- conf/modules.config | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index c44a6dfd1..930a1d579 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -282,7 +282,7 @@ if (params.aligner == 'star') { process { withName: 'PICARD_MERGESAMFILES' { - ext.args = 'SORT_ORDER=coordinate VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' + ext.args = '--SORT_ORDER coordinate --VALIDATION_STRINGENCY LENIENT --TMP_DIR tmp' ext.prefix = { "${meta.id}.mLb.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, @@ -422,7 +422,7 @@ process { if (!params.skip_picard_metrics) { process { withName: 'PICARD_COLLECTMULTIPLEMETRICS' { - ext.args = 'VALIDATION_STRINGENCY=LENIENT TMP_DIR=tmp' + ext.args = '--VALIDATION_STRINGENCY LENIENT --TMP_DIR tmp' ext.prefix = { "${meta.id}.mLb.clN.sorted" } publishDir = [ [ From 33d3bdda056cc66bd6c9070bc0abf670e9c6c229 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 3 May 2022 12:54:17 +0200 Subject: [PATCH 389/538] Address PR comments (gunzip also has meta ,...) --- subworkflows/local/prepare_genome.nf | 16 ++++++++-------- 1 file changed, 8 insertions(+), 8 deletions(-) diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index 33aa189ed..32dd3e585 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -37,7 +37,7 @@ workflow PREPARE_GENOME { // ch_fasta = Channel.empty() if (params.fasta.endsWith('.gz')) { - ch_fasta = GUNZIP_FASTA ( params.fasta ).gunzip + ch_fasta = GUNZIP_FASTA ( [:], params.fasta ).gunzip.map{ it[1] } ch_versions = ch_versions.mix(GUNZIP_FASTA.out.versions) } else { ch_fasta = file(params.fasta) @@ -48,14 +48,14 @@ workflow PREPARE_GENOME { // if (params.gtf) { if (params.gtf.endsWith('.gz')) { - ch_gtf = GUNZIP_GTF ( params.gtf ).gunzip + ch_gtf = GUNZIP_GTF ( [:], params.gtf ).gunzip.map{ it[1] } ch_versions = ch_versions.mix(GUNZIP_GTF.out.versions) } else { ch_gtf = file(params.gtf) } } else if (params.gff) { if (params.gff.endsWith('.gz')) { - ch_gff = GUNZIP_GFF ( params.gff ).gunzip + ch_gff = GUNZIP_GFF ( [:], params.gff ).gunzip.map{ it[1] } ch_versions = ch_versions.mix(GUNZIP_GFF.out.versions) } else { ch_gff = file(params.gff) @@ -70,7 +70,7 @@ workflow PREPARE_GENOME { ch_blacklist = Channel.empty() if (params.blacklist) { if (params.blacklist.endsWith('.gz')) { - ch_blacklist = GUNZIP_BLACKLIST ( params.blacklist ).gunzip + ch_blacklist = GUNZIP_BLACKLIST ( [:], params.blacklist ).gunzip.map{ it[1] } ch_versions = ch_versions.mix(GUNZIP_BLACKLIST.out.versions) } else { ch_blacklist = Channel.fromPath(file(params.blacklist)) @@ -97,7 +97,7 @@ workflow PREPARE_GENOME { ch_versions = ch_versions.mix(GTF2BED.out.versions) } else { if (params.gene_bed.endsWith('.gz')) { - ch_gene_bed = GUNZIP_GENE_BED ( params.gene_bed ).gunzip + ch_gene_bed = GUNZIP_GENE_BED ( [:], params.gene_bed ).gunzip.map{ it[1] } ch_versions = ch_versions.mix(GUNZIP_GENE_BED.out.versions) } else { ch_gene_bed = file(params.gene_bed) @@ -130,7 +130,7 @@ workflow PREPARE_GENOME { if (prepare_tool_index == 'bwa') { if (params.bwa_index) { if (params.bwa_index.endsWith('.tar.gz')) { - ch_bwa_index = UNTAR_BWA_INDEX ( [], params.bwa_index ).untar.map{it -> it[1]} + ch_bwa_index = UNTAR_BWA_INDEX ( [:], params.bwa_index ).untar.map{ it[1] } ch_versions = ch_versions.mix(UNTAR_BWA_INDEX.out.versions) } else { ch_bwa_index = file(params.bwa_index) @@ -148,7 +148,7 @@ workflow PREPARE_GENOME { if (prepare_tool_index == 'bowtie2') { if (params.bowtie2_index) { if (params.bowtie2_index.endsWith('.tar.gz')) { - ch_bowtie2_index = UNTAR_BOWTIE2_INDEX ( [], params.bowtie2_index ).untar.map{it -> it[1]} + ch_bowtie2_index = UNTAR_BOWTIE2_INDEX ( [:], params.bowtie2_index ).untar.map{ it[1] } ch_versions = ch_versions.mix(UNTAR_BOWTIE2_INDEX.out.versions) } else { ch_bowtie2_index = file(params.bowtie2_index) @@ -184,7 +184,7 @@ workflow PREPARE_GENOME { if (prepare_tool_index == 'star') { if (params.star_index) { if (params.star_index.endsWith('.tar.gz')) { - ch_star_index = UNTAR_STAR_INDEX ( [], params.star_index ).untar.map{it -> it[1]} + ch_star_index = UNTAR_STAR_INDEX ( [:], params.star_index ).untar.map{ it[1] } ch_versions = ch_versions.mix(UNTAR_STAR_INDEX.out.versions) } else { ch_star_index = file(params.star_index) From c70659ff4538dc367ec2166a8ef47b4bfae496f8 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Mon, 9 May 2022 11:11:31 +0100 Subject: [PATCH 390/538] Replace last remaining vanilla Linux Biocontainer --- modules/local/multiqc_custom_peaks.nf | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/modules/local/multiqc_custom_peaks.nf b/modules/local/multiqc_custom_peaks.nf index 64f918c4f..7eb6487d8 100644 --- a/modules/local/multiqc_custom_peaks.nf +++ b/modules/local/multiqc_custom_peaks.nf @@ -2,8 +2,8 @@ process MULTIQC_CUSTOM_PEAKS { conda (params.enable_conda ? "conda-forge::sed=4.7" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://containers.biocontainers.pro/s3/SingImgsRepo/biocontainers/v1.2.0_cv1/biocontainers_v1.2.0_cv1.img': - 'biocontainers/biocontainers:v1.2.0_cv1' }" + 'https://depot.galaxyproject.org/singularity/ubuntu:20.04' : + 'ubuntu:20.04' }" input: tuple val(meta), path(peak), path(frip) From 458d121609bdc89bc959542f17202f9d48df4b36 Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Mon, 16 May 2022 10:16:07 +0000 Subject: [PATCH 391/538] Template update for nf-core/tools version 2.4 --- .github/workflows/awsfulltest.yml | 3 - .github/workflows/awstest.yml | 3 - .github/workflows/branch.yml | 3 +- .github/workflows/ci.yml | 2 - .github/workflows/fix-linting.yml | 55 ++++++++++ .github/workflows/linting.yml | 4 +- .github/workflows/linting_comment.yml | 1 - .prettierignore | 9 ++ README.md | 25 ++--- assets/email_template.html | 142 ++++++++------------------ bin/check_samplesheet.py | 16 ++- nextflow.config | 2 +- 12 files changed, 135 insertions(+), 130 deletions(-) create mode 100644 .github/workflows/fix-linting.yml create mode 100644 .prettierignore diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index 700ff9000..c6f0c9c60 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -28,6 +28,3 @@ jobs: "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-${{ github.sha }}" } profiles: test_full,aws_tower - nextflow_config: | - process.errorStrategy = 'retry' - process.maxRetries = 3 diff --git a/.github/workflows/awstest.yml b/.github/workflows/awstest.yml index 666c70a31..73640cc6f 100644 --- a/.github/workflows/awstest.yml +++ b/.github/workflows/awstest.yml @@ -23,6 +23,3 @@ jobs: "outdir": "s3://${{ secrets.AWS_S3_BUCKET }}/chipseq/results-test-${{ github.sha }}" } profiles: test,aws_tower - nextflow_config: | - process.errorStrategy = 'retry' - process.maxRetries = 3 diff --git a/.github/workflows/branch.yml b/.github/workflows/branch.yml index 5a5468e14..1e03d409b 100644 --- a/.github/workflows/branch.yml +++ b/.github/workflows/branch.yml @@ -13,7 +13,7 @@ jobs: - name: Check PRs if: github.repository == 'nf-core/chipseq' run: | - "{ [[ ${{github.event.pull_request.head.repo.full_name }} == nf-core/chipseq ]] && [[ $GITHUB_HEAD_REF = "dev" ]]; } || [[ $GITHUB_HEAD_REF == "patch" ]]" + { [[ ${{github.event.pull_request.head.repo.full_name }} == nf-core/chipseq ]] && [[ $GITHUB_HEAD_REF = "dev" ]]; } || [[ $GITHUB_HEAD_REF == "patch" ]] # If the above check failed, post a comment on the PR explaining the failure # NOTE - this doesn't currently work if the PR is coming from a fork, due to limitations in GitHub actions secrets @@ -42,4 +42,3 @@ jobs: Thanks again for your contribution! repo-token: ${{ secrets.GITHUB_TOKEN }} allow-repeats: false -# diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index b78f34dff..0596f36fc 100644 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -48,5 +48,3 @@ jobs: # Remember that you can parallelise this by using strategy.matrix run: | nextflow run ${GITHUB_WORKSPACE} -profile test,docker --outdir ./results - -# diff --git a/.github/workflows/fix-linting.yml b/.github/workflows/fix-linting.yml new file mode 100644 index 000000000..b4f90734c --- /dev/null +++ b/.github/workflows/fix-linting.yml @@ -0,0 +1,55 @@ +name: Fix linting from a comment +on: + issue_comment: + types: [created] + +jobs: + deploy: + # Only run if comment is on a PR with the main repo, and if it contains the magic keywords + if: > + contains(github.event.comment.html_url, '/pull/') && + contains(github.event.comment.body, '@nf-core-bot fix linting') && + github.repository == 'nf-core/chipseq' + runs-on: ubuntu-latest + steps: + # Use the @nf-core-bot token to check out so we can push later + - uses: actions/checkout@v3 + with: + token: ${{ secrets.nf_core_bot_auth_token }} + + # Action runs on the issue comment, so we don't get the PR by default + # Use the gh cli to check out the PR + - name: Checkout Pull Request + run: gh pr checkout ${{ github.event.issue.number }} + env: + GITHUB_TOKEN: ${{ secrets.nf_core_bot_auth_token }} + + - uses: actions/setup-node@v2 + + - name: Install Prettier + run: npm install -g prettier @prettier/plugin-php + + # Check that we actually need to fix something + - name: Run 'prettier --check' + id: prettier_status + run: | + if prettier --check ${GITHUB_WORKSPACE}; then + echo "::set-output name=result::pass" + else + echo "::set-output name=result::fail" + fi + + - name: Run 'prettier --write' + if: steps.prettier_status.outputs.result == 'fail' + run: prettier --write ${GITHUB_WORKSPACE} + + - name: Commit & push changes + if: steps.prettier_status.outputs.result == 'fail' + run: | + git config user.email "core@nf-co.re" + git config user.name "nf-core-bot" + git config push.default upstream + git add . + git status + git commit -m "[automated] Fix linting with Prettier" + git push diff --git a/.github/workflows/linting.yml b/.github/workflows/linting.yml index e9cf5de3a..77358dee7 100644 --- a/.github/workflows/linting.yml +++ b/.github/workflows/linting.yml @@ -48,7 +48,7 @@ jobs: wget -qO- get.nextflow.io | bash sudo mv nextflow /usr/local/bin/ - - uses: actions/setup-python@v1 + - uses: actions/setup-python@v3 with: python-version: "3.6" architecture: "x64" @@ -78,5 +78,3 @@ jobs: lint_log.txt lint_results.md PR_number.txt - -# diff --git a/.github/workflows/linting_comment.yml b/.github/workflows/linting_comment.yml index 91c487a1a..04758f61e 100644 --- a/.github/workflows/linting_comment.yml +++ b/.github/workflows/linting_comment.yml @@ -26,4 +26,3 @@ jobs: GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }} number: ${{ steps.pr_number.outputs.pr_number }} path: linting-logs/lint_results.md -# diff --git a/.prettierignore b/.prettierignore new file mode 100644 index 000000000..d0e7ae589 --- /dev/null +++ b/.prettierignore @@ -0,0 +1,9 @@ +email_template.html +.nextflow* +work/ +data/ +results/ +.DS_Store +testing/ +testing* +*.pyc diff --git a/README.md b/README.md index 71c912997..45ee3b4fc 100644 --- a/README.md +++ b/README.md @@ -1,18 +1,19 @@ -# ![nf-core/chipseq](docs/images/nf-core/chipseq_logo_light.png#gh-light-mode-only) ![nf-core/chipseq](docs/images/nf-core/chipseq_logo_dark.png#gh-dark-mode-only) +# ![nf-core/chipseq](docs/images/nf-core-chipseq_logo_light.png#gh-light-mode-only) ![nf-core/chipseq](docs/images/nf-core-chipseq_logo_dark.png#gh-dark-mode-only) [![GitHub Actions CI Status](https://github.com/nf-core/chipseq/workflows/nf-core%20CI/badge.svg)](https://github.com/nf-core/chipseq/actions?query=workflow%3A%22nf-core+CI%22) [![GitHub Actions Linting Status](https://github.com/nf-core/chipseq/workflows/nf-core%20linting/badge.svg)](https://github.com/nf-core/chipseq/actions?query=workflow%3A%22nf-core+linting%22) -[![AWS CI](https://img.shields.io/badge/CI%20tests-full%20size-FF9900?labelColor=000000&logo=Amazon%20AWS)](https://nf-co.re/chipseq/results) -[![Cite with Zenodo](http://img.shields.io/badge/DOI-10.5281/zenodo.XXXXXXX-1073c8?labelColor=000000)](https://doi.org/10.5281/zenodo.XXXXXXX) - -[![Nextflow](https://img.shields.io/badge/nextflow%20DSL2-%E2%89%A521.10.3-23aa62.svg?labelColor=000000)](https://www.nextflow.io/) -[![run with conda](http://img.shields.io/badge/run%20with-conda-3EB049?labelColor=000000&logo=anaconda)](https://docs.conda.io/en/latest/) -[![run with docker](https://img.shields.io/badge/run%20with-docker-0db7ed?labelColor=000000&logo=docker)](https://www.docker.com/) -[![run with singularity](https://img.shields.io/badge/run%20with-singularity-1d355c.svg?labelColor=000000)](https://sylabs.io/docs/) - -[![Get help on Slack](http://img.shields.io/badge/slack-nf--core%20%23chipseq-4A154B?labelColor=000000&logo=slack)](https://nfcore.slack.com/channels/chipseq) -[![Follow on Twitter](http://img.shields.io/badge/twitter-%40nf__core-1DA1F2?labelColor=000000&logo=twitter)](https://twitter.com/nf_core) -[![Watch on YouTube](http://img.shields.io/badge/youtube-nf--core-FF0000?labelColor=000000&logo=youtube)](https://www.youtube.com/c/nf-core) +[![AWS CI](https://img.shields.io/badge/CI%20tests-full%20size-FF9900?logo=Amazon%20AWS)](https://nf-co.re/chipseq/results) +[![Cite with Zenodo](http://img.shields.io/badge/DOI-10.5281/zenodo.XXXXXXX-1073c8)](https://doi.org/10.5281/zenodo.XXXXXXX) + +[![Nextflow](https://img.shields.io/badge/nextflow%20DSL2-%E2%89%A521.10.3-23aa62.svg)](https://www.nextflow.io/) +[![run with conda](http://img.shields.io/badge/run%20with-conda-3EB049?logo=anaconda)](https://docs.conda.io/en/latest/) +[![run with docker](https://img.shields.io/badge/run%20with-docker-0db7ed?logo=docker)](https://www.docker.com/) +[![run with singularity](https://img.shields.io/badge/run%20with-singularity-1d355c.svg)](https://sylabs.io/docs/) +[![Launch on Nextflow Tower](https://img.shields.io/badge/Launch%20%F0%9F%9A%80-Nextflow%20Tower-%234256e7)](https://tower.nf/launch?pipeline=https://github.com/nf-core/chipseq) + +[![Get help on Slack](http://img.shields.io/badge/slack-nf--core%20%23chipseq-4A154B?logo=slack)](https://nfcore.slack.com/channels/chipseq) +[![Follow on Twitter](http://img.shields.io/badge/twitter-%40nf__core-1DA1F2?logo=twitter)](https://twitter.com/nf_core) +[![Watch on YouTube](http://img.shields.io/badge/youtube-nf--core-FF0000?logo=youtube)](https://www.youtube.com/c/nf-core) ## Introduction diff --git a/assets/email_template.html b/assets/email_template.html index 5c35a97ba..5a4548bb0 100644 --- a/assets/email_template.html +++ b/assets/email_template.html @@ -1,111 +1,53 @@ - - - - + + + + - - - nf-core/chipseq Pipeline Report - - -
- + + nf-core/chipseq Pipeline Report + + +
-

nf-core/chipseq v${version}

-

Run Name: $runName

+ - <% if (!success){ out << """ -
-

nf-core/chipseq execution completed unsuccessfully!

+

nf-core/chipseq v${version}

+

Run Name: $runName

+ +<% if (!success){ + out << """ +
+

nf-core/chipseq execution completed unsuccessfully!

The exit status of the task that caused the workflow execution to fail was: $exitStatus.

The full error message was:

- 
${errorReport}
-
- """ } else { out << """ -
+ 
${errorReport}
+
+ """ +} else { + out << """ +
nf-core/chipseq execution completed successfully! -
- """ } %> +
+ """ +} +%> -

The workflow was completed at $dateComplete (duration: $duration)

-

The command used to launch the workflow was as follows:

- 
-$commandLine
+

The workflow was completed at $dateComplete (duration: $duration)

+

The command used to launch the workflow was as follows:

+
$commandLine
-

Pipeline Configuration:

- - - <% out << summary.collect{ k,v -> " - - - - - " }.join("\n") %> - -
- $k - - 
$v
-
+

Pipeline Configuration:

+ + + <% out << summary.collect{ k,v -> "" }.join("\n") %> + +
$k
$v
-

nf-core/chipseq

-

https://github.com/nf-core/chipseq

-
- +

nf-core/chipseq

+

https://github.com/nf-core/chipseq

+ +
+ + diff --git a/bin/check_samplesheet.py b/bin/check_samplesheet.py index 5473b624c..3652c63c8 100755 --- a/bin/check_samplesheet.py +++ b/bin/check_samplesheet.py @@ -98,7 +98,7 @@ def _validate_pair(self, row): if row[self._first_col] and row[self._second_col]: row[self._single_col] = False assert ( - Path(row[self._first_col]).suffixes == Path(row[self._second_col]).suffixes + Path(row[self._first_col]).suffixes[-2:] == Path(row[self._second_col]).suffixes[-2:] ), "FASTQ pairs must have the same file extensions." else: row[self._single_col] = True @@ -129,6 +129,16 @@ def validate_unique_samples(self): row[self._sample_col] = f"{sample}_T{seen[sample]}" +def read_head(handle, num_lines=10): + """Read the specified number of lines from the current position in the file.""" + lines = [] + for idx, line in enumerate(handle): + if idx == num_lines: + break + lines.append(line) + return "".join(lines) + + def sniff_format(handle): """ Detect the tabular format. @@ -144,13 +154,13 @@ def sniff_format(handle): https://docs.python.org/3/glossary.html#term-text-file """ - peek = handle.read(2048) + peek = read_head(handle) + handle.seek(0) sniffer = csv.Sniffer() if not sniffer.has_header(peek): logger.critical(f"The given sample sheet does not appear to contain a header.") sys.exit(1) dialect = sniffer.sniff(peek) - handle.seek(0) return dialect diff --git a/nextflow.config b/nextflow.config index d7b8696c4..6c5ab6b95 100644 --- a/nextflow.config +++ b/nextflow.config @@ -159,7 +159,7 @@ trace { } dag { enabled = true - file = "${params.tracedir}/pipeline_dag_${trace_timestamp}.svg" + file = "${params.tracedir}/pipeline_dag_${trace_timestamp}.html" } manifest { From a6eb7812f070fb88542f7e57c6a175992f7d5068 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 17 May 2022 10:48:52 +0200 Subject: [PATCH 392/538] Uncomment again cromap in test --- .github/workflows/ci.yml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index d968b6343..4a040e5c3 100755 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -76,7 +76,7 @@ jobs: matrix: aligner: - "bowtie2" - - "chromap" + # - "chromap" - "star" steps: - name: Check out pipeline code From d2968e41af07edb060d815ee06813905c9b1517b Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 17 May 2022 12:08:44 +0200 Subject: [PATCH 393/538] Fix readme zenodo link --- README.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/README.md b/README.md index 364e90da0..91c27e231 100644 --- a/README.md +++ b/README.md @@ -3,7 +3,7 @@ [![GitHub Actions CI Status](https://github.com/nf-core/chipseq/workflows/nf-core%20CI/badge.svg)](https://github.com/nf-core/chipseq/actions?query=workflow%3A%22nf-core+CI%22) [![GitHub Actions Linting Status](https://github.com/nf-core/chipseq/workflows/nf-core%20linting/badge.svg)](https://github.com/nf-core/chipseq/actions?query=workflow%3A%22nf-core+linting%22) [![AWS CI](https://img.shields.io/badge/CI%20tests-full%20size-FF9900?logo=Amazon%20AWS)](https://nf-co.re/chipseq/results) -[![Cite with Zenodo](http://img.shields.io/badge/DOI-10.5281/zenodo.XXXXXXX-1073c8)](https://doi.org/10.5281/zenodo.XXXXXXX) +[![Cite with Zenodo](http://img.shields.io/badge/DOI-10.5281/zenodo.-1073c8)](https://doi.org/10.5281/zenodo.3240506) [![Nextflow](https://img.shields.io/badge/nextflow%20DSL2-%E2%89%A521.10.3-23aa62.svg)](https://www.nextflow.io/) [![run with conda](http://img.shields.io/badge/run%20with-conda-3EB049?logo=anaconda)](https://docs.conda.io/en/latest/) From 7b574746548ee753957896aa3b27f7acada26aa8 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 17 May 2022 12:16:22 +0200 Subject: [PATCH 394/538] Update changelog --- CHANGELOG.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 9fda27321..e8cde001e 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -7,10 +7,10 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 ### Enhancements & fixes +- Updated pipeline template to [nf-core/tools 2.4.2](https://github.com/nf-core/tools/releases/tag/2.4.2) - [[#128](https://github.com/nf-core/chipseq/issues/128)] - Filter files with no peaks to avoid errors in downstream processes - [[#220](https://github.com/nf-core/chipseq/issues/220)] - Fix `phantompeakqualtools` protection stack overflow error - [[#233](https://github.com/nf-core/chipseq/issues/233)] - Add `chromap` to the available aligners -- Updated pipeline template to [nf-core/tools 2.3.2](https://github.com/nf-core/tools/releases/tag/2.3.2) - Port pipeline to the updated Nextflow DSL2 syntax adopted on nf-core/modules - Bump minimum Nextflow version from `21.04.0` -> `21.10.3` - Added `python3` shebang to appropriate scripts in `bin/` directory From c8c3119a944e66799ed0807d418318eb1d725d9e Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 17 May 2022 12:19:12 +0200 Subject: [PATCH 395/538] Correct tools version in changelog --- CHANGELOG.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index e8cde001e..6928ed449 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -7,7 +7,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 ### Enhancements & fixes -- Updated pipeline template to [nf-core/tools 2.4.2](https://github.com/nf-core/tools/releases/tag/2.4.2) +- Updated pipeline template to [nf-core/tools 2.4.1](https://github.com/nf-core/tools/releases/tag/2.4.1) - [[#128](https://github.com/nf-core/chipseq/issues/128)] - Filter files with no peaks to avoid errors in downstream processes - [[#220](https://github.com/nf-core/chipseq/issues/220)] - Fix `phantompeakqualtools` protection stack overflow error - [[#233](https://github.com/nf-core/chipseq/issues/233)] - Add `chromap` to the available aligners From 06a43724b6f52ed6515bce6c1c244bea37268640 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 18 May 2022 15:44:34 +0200 Subject: [PATCH 396/538] Add deeptools plotfingerprint labels --- conf/modules.config | 7 ++++--- 1 file changed, 4 insertions(+), 3 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 930a1d579..d995efdb2 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -489,10 +489,11 @@ if (!params.skip_plot_profile) { if (!params.skip_plot_fingerprint) { process { withName: 'DEEPTOOLS_PLOTFINGERPRINT' { - ext.args = [ + ext.args = { [ '--skipZeros', - "--numberOfSamples $params.fingerprint_bins" - ].join(' ').trim() + "--numberOfSamples $params.fingerprint_bins", + "--labels $meta.ip $meta.control" + ].join(' ').trim() } ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotFingerprint" }, From 9de3362c4d71a463c58e7ee243513affe6f5564e Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 18 May 2022 15:46:32 +0200 Subject: [PATCH 397/538] Fix channel assignation --- subworkflows/local/filter_bam_bamtools.nf | 1 - workflows/chipseq.nf | 2 +- 2 files changed, 1 insertion(+), 2 deletions(-) diff --git a/subworkflows/local/filter_bam_bamtools.nf b/subworkflows/local/filter_bam_bamtools.nf index 8472ce5d0..40e9b1be6 100644 --- a/subworkflows/local/filter_bam_bamtools.nf +++ b/subworkflows/local/filter_bam_bamtools.nf @@ -14,7 +14,6 @@ workflow FILTER_BAM_BAMTOOLS { bamtools_filter_pe_config // file: BAMtools filter JSON config file for PE data main: - ch_versions = Channel.empty() BAM_FILTER(ch_bam_bai, ch_bed, bamtools_filter_se_config, bamtools_filter_pe_config) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 625632528..d8ee01872 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -279,7 +279,7 @@ workflow CHIPSEQ { FILTER_BAM_BAMTOOLS.out.bam, PREPARE_GENOME.out.fasta ) - ch_picardcollectmultiplemetrics_multiqc = MARK_DUPLICATES_PICARD.out.metrics + ch_picardcollectmultiplemetrics_multiqc = PICARD_COLLECTMULTIPLEMETRICS.out.metrics ch_versions = ch_versions.mix(PICARD_COLLECTMULTIPLEMETRICS.out.versions.first()) } From 3faadf01d14b95c43447fb55897941820c3f6275 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 18 May 2022 16:11:09 +0200 Subject: [PATCH 398/538] Fix assignation of pvalue and qvalue for macs2 callpeak --- conf/modules.config | 56 ++++++++++++++++++++++++--------------------- 1 file changed, 30 insertions(+), 26 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index d995efdb2..c679be345 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -511,8 +511,8 @@ if (params.macs_gsize) { '--keep-dup all', params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}", params.save_macs_pileup ? '--bdg --SPMR' : '', - params.macs_fdr ? "--pvalue ${params.macs_pvalue}" : '', - params.macs_pvalue ? "--qvalue ${params.macs_fdr}" : '' + params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '', + params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' ].join(' ').trim() publishDir = [ path: { [ @@ -549,21 +549,8 @@ if (params.macs_gsize) { } } - if (!params.skip_peak_annotation && !params.skip_peak_qc) { + if (!params.skip_peak_annotation) { process { - withName: 'PLOT_MACS2_QC' { - ext.args = '-o ./ -p macs2_peak' - publishDir = [ - path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/qc' - ].join('') }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - withName: 'HOMER_ANNOTATEPEAKS_MACS2' { ext.args = '-gid' // ext.prefix = 'peaks' @@ -576,18 +563,35 @@ if (params.macs_gsize) { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } + } - withName: 'PLOT_HOMER_ANNOTATEPEAKS' { - ext.args = '-o ./ -p macs2_annotatePeaks' - publishDir = [ - path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/qc' + if (!params.skip_peak_qc) { + process { + withName: 'PLOT_MACS2_QC' { + ext.args = '-o ./ -p macs2_peak' + publishDir = [ + path: { [ + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/qc' ].join('') }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + + withName: 'PLOT_HOMER_ANNOTATEPEAKS' { + ext.args = '-o ./ -p macs2_annotatePeaks' + publishDir = [ + path: { [ + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/qc' + ].join('') }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } } } } From ab1afe328a24f10de872c11ccaea4f9ebd2cfcdc Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 19 May 2022 10:24:41 +0200 Subject: [PATCH 399/538] Fix skip_peak_annotation and skip_peak_qc options --- workflows/chipseq.nf | 28 +++++++++++++++------------- 1 file changed, 15 insertions(+), 13 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index d8ee01872..726fc48fb 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -438,12 +438,7 @@ workflow CHIPSEQ { ch_custompeaks_frip_multiqc = MULTIQC_CUSTOM_PEAKS.out.frip ch_custompeaks_count_multiqc = MULTIQC_CUSTOM_PEAKS.out.count - if (!params.skip_peak_annotation && !params.skip_peak_qc) { - PLOT_MACS2_QC ( - ch_macs2_peaks.collect{it[1]} - ) - ch_versions = ch_versions.mix(PLOT_MACS2_QC.out.versions) - + if (!params.skip_peak_annotation) { HOMER_ANNOTATEPEAKS_MACS2 ( ch_macs2_peaks, PREPARE_GENOME.out.fasta, @@ -451,13 +446,20 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first()) - PLOT_HOMER_ANNOTATEPEAKS ( - HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, - ch_peak_annotation_header, - "_peaks.annotatePeaks.txt" - ) - ch_plothomerannotatepeaks_multiqc = PLOT_HOMER_ANNOTATEPEAKS.out.tsv - ch_versions = ch_versions.mix(PLOT_HOMER_ANNOTATEPEAKS.out.versions) + if (!params.skip_peak_qc) { + PLOT_MACS2_QC ( + ch_macs2_peaks.collect{it[1]} + ) + ch_versions = ch_versions.mix(PLOT_MACS2_QC.out.versions) + + PLOT_HOMER_ANNOTATEPEAKS ( + HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, + ch_peak_annotation_header, + "_peaks.annotatePeaks.txt" + ) + ch_plothomerannotatepeaks_multiqc = PLOT_HOMER_ANNOTATEPEAKS.out.tsv + ch_versions = ch_versions.mix(PLOT_HOMER_ANNOTATEPEAKS.out.versions) + } } // From 377028f4df1ff0c1cfef8de001cef3049685a204 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 19 May 2022 10:25:38 +0200 Subject: [PATCH 400/538] Aligning code in emits of local modules --- modules/local/multiqc_custom_peaks.nf | 2 +- modules/local/multiqc_custom_phantompeakqualtools.nf | 4 ++-- modules/local/plot_homer_annotatepeaks.nf | 6 +++--- 3 files changed, 6 insertions(+), 6 deletions(-) diff --git a/modules/local/multiqc_custom_peaks.nf b/modules/local/multiqc_custom_peaks.nf index 7eb6487d8..1ca41d4ce 100644 --- a/modules/local/multiqc_custom_peaks.nf +++ b/modules/local/multiqc_custom_peaks.nf @@ -12,7 +12,7 @@ process MULTIQC_CUSTOM_PEAKS { output: tuple val(meta), path("*.peak_count_mqc.tsv"), emit: count - tuple val(meta), path("*.FRiP_mqc.tsv"), emit: frip + tuple val(meta), path("*.FRiP_mqc.tsv") , emit: frip script: def prefix = task.ext.prefix ?: "${meta.id}" diff --git a/modules/local/multiqc_custom_phantompeakqualtools.nf b/modules/local/multiqc_custom_phantompeakqualtools.nf index 2e9118237..706af4fc0 100644 --- a/modules/local/multiqc_custom_phantompeakqualtools.nf +++ b/modules/local/multiqc_custom_phantompeakqualtools.nf @@ -11,8 +11,8 @@ process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { path correlation_header output: - tuple val(meta), path("*.spp_nsc_mqc.tsv"), emit: nsc - tuple val(meta), path("*.spp_rsc_mqc.tsv"), emit: rsc + tuple val(meta), path("*.spp_nsc_mqc.tsv") , emit: nsc + tuple val(meta), path("*.spp_rsc_mqc.tsv") , emit: rsc tuple val(meta), path("*.spp_correlation_mqc.tsv"), emit: correlation script: diff --git a/modules/local/plot_homer_annotatepeaks.nf b/modules/local/plot_homer_annotatepeaks.nf index 0873e38eb..2cb38a373 100644 --- a/modules/local/plot_homer_annotatepeaks.nf +++ b/modules/local/plot_homer_annotatepeaks.nf @@ -12,9 +12,9 @@ process PLOT_HOMER_ANNOTATEPEAKS { val suffix output: - path '*.txt', emit: txt - path '*.pdf', emit: pdf - path '*.tsv', emit: tsv + path '*.txt' , emit: txt + path '*.pdf' , emit: pdf + path '*.tsv' , emit: tsv path "versions.yml", emit: versions script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ From d3ff899fcf2e0b91508371939636537a0c254270 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 19 May 2022 15:52:54 +0200 Subject: [PATCH 401/538] Preseq run on the output of picard markduplicates and not after removing orphans --- workflows/chipseq.nf | 24 ++++++++++++------------ 1 file changed, 12 insertions(+), 12 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 726fc48fb..a76bcdd83 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -270,6 +270,18 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(FILTER_BAM_BAMTOOLS.out.versions.first().ifEmpty(null)) + // + // MODULE: Library coverage + // + ch_preseq_multiqc = Channel.empty() + if (!params.skip_preseq) { + PRESEQ_LCEXTRAP ( + MARK_DUPLICATES_PICARD.out.bam + ) + ch_preseq_multiqc = PRESEQ_LCEXTRAP.out.lc_extrap + ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions.first()) + } + // // MODULE: Post alignment QC // @@ -283,18 +295,6 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(PICARD_COLLECTMULTIPLEMETRICS.out.versions.first()) } - // - // MODULE: Library coverage - // - ch_preseq_multiqc = Channel.empty() - if (!params.skip_preseq) { - PRESEQ_LCEXTRAP ( - FILTER_BAM_BAMTOOLS.out.bam - ) - ch_preseq_multiqc = PRESEQ_LCEXTRAP.out.lc_extrap - ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions.first()) - } - // // MODULE: Strand cross-correlation // From d9eddb39a5681b1c266cfeadc8d44c07884aba44 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 25 May 2022 23:18:06 +0200 Subject: [PATCH 402/538] Remove input from required params --- nextflow_schema.json | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index cb99b41f5..7429b1cbf 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -10,7 +10,7 @@ "type": "object", "fa_icon": "fas fa-terminal", "description": "Define where the pipeline should find input data and save output data.", - "required": ["input", "outdir"], + "required": ["outdir"], "properties": { "input": { "type": "string", From a20cf2a35c6e64aede52a618ca479d836df19e08 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 26 May 2022 11:51:44 +0200 Subject: [PATCH 403/538] Remove multiqc headers that were defined twice --- workflows/chipseq.nf | 8 +++++--- 1 file changed, 5 insertions(+), 3 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index a76bcdd83..29e2fc3b1 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -486,7 +486,7 @@ workflow CHIPSEQ { meta.replicates_exist = groups.max { groups.value }.value > 1 [ meta, peaks ] } .set { ch_antibody_peaks } - + // ch_antibody_peaks.dump() MACS2_CONSENSUS ( ch_antibody_peaks ) @@ -510,11 +510,15 @@ workflow CHIPSEQ { .map { meta, saf -> [ meta.id, meta, saf ] } .set { ch_ip_saf } + // ch_ip_saf.dump() + ch_ip_control_bam .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } .groupTuple() .map { it -> [ it[0], it[1][0], it[2].flatten().sort() ] } + // .dump() .join(ch_ip_saf) + .dump() .map { it -> fmeta = it[1] @@ -530,8 +534,6 @@ workflow CHIPSEQ { ch_subreadfeaturecounts_multiqc = SUBREAD_FEATURECOUNTS.out.summary ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first()) - ch_deseq2_pca_header = file("$projectDir/assets/multiqc/deseq2_pca_header.txt", checkIfExists: true) - ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering_header.txt", checkIfExists: true) if (!params.skip_deseq2_qc) { DESEQ2_QC ( SUBREAD_FEATURECOUNTS.out.counts, From fae13fa88582c5da749fcb1b902ce02647b2ab7b Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 26 May 2022 12:04:37 +0200 Subject: [PATCH 404/538] Fix reference to chipseq in multiqc headers --- assets/multiqc/deseq2_clustering_header.txt | 2 +- assets/multiqc/deseq2_pca_header.txt | 2 +- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/assets/multiqc/deseq2_clustering_header.txt b/assets/multiqc/deseq2_clustering_header.txt index a8e8adb96..3dd28211b 100644 --- a/assets/multiqc/deseq2_clustering_header.txt +++ b/assets/multiqc/deseq2_clustering_header.txt @@ -3,7 +3,7 @@ #description: "is generated from clustering the Euclidean distances between # DESeq2 # rlog values for each sample -# in the deseq2_qc.r script." +# in the deseq2_qc.r script." #plot_type: 'heatmap' #anchor: 'deseq2_clustering' #pconfig: diff --git a/assets/multiqc/deseq2_pca_header.txt b/assets/multiqc/deseq2_pca_header.txt index da7660b02..55b0bbadf 100644 --- a/assets/multiqc/deseq2_pca_header.txt +++ b/assets/multiqc/deseq2_pca_header.txt @@ -2,7 +2,7 @@ #section_name: 'MERGED LIB: DESeq2 PCA plot' #description: "PCA plot between samples in the experiment. # These values are calculated using DESeq2 -# in the deseq2_qc.r script." +# in the deseq2_qc.r script." #plot_type: 'scatter' #anchor: 'deseq2_pca' #pconfig: From 770921e1b7bfad9063cdc22f47234871e2264e5d Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 16 Jun 2022 23:32:05 +0200 Subject: [PATCH 405/538] Fix nested conditions --- conf/modules.config | 90 ++++++++++++++++++++++----------------------- 1 file changed, 45 insertions(+), 45 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index c679be345..af24b735c 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -624,59 +624,59 @@ if (params.macs_gsize) { ] } } - } - if (!params.skip_peak_annotation) { - process { - withName: 'HOMER_ANNOTATEPEAKS_CONSENSUS' { - ext.args = '-gid' - ext.prefix = 'consensus_peaks' - publishDir = [ - path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus' - ].join('') }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - } - } - - if (!params.skip_deseq2_qc) { - process { - withName: DESEQ2_QC { - ext.args = [ - '--id_col 1', - '--sample_suffix \'.mLb.clN.sorted.bam\'', - '--count_col 7', - params.deseq2_vst ? '--vst TRUE' : '' - ].join(' ').trim() - publishDir = [ - path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus/deseq2' - ].join('') }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] + if (!params.skip_peak_annotation) { + process { + withName: 'HOMER_ANNOTATEPEAKS_CONSENSUS' { + ext.args = '-gid' + ext.prefix = 'consensus_peaks' + publishDir = [ + path: { [ + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/consensus' + ].join('') }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } } } - } - if (!params.skip_igv) { - process { - withName: 'IGV' { - publishDir = [ + if (!params.skip_deseq2_qc) { + process { + withName: DESEQ2_QC { + ext.args = [ + '--id_col 1', + '--sample_suffix \'.mLb.clN.sorted.bam\'', + '--count_col 7', + params.deseq2_vst ? '--vst TRUE' : '' + ].join(' ').trim() + publishDir = [ path: { [ - "${params.outdir}/igv", - params.narrow_peak? '/narrowPeak' : '/broadPeak' + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/consensus/deseq2' ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] + ] + } + } + } + + if (!params.skip_igv) { + process { + withName: 'IGV' { + publishDir = [ + path: { [ + "${params.outdir}/igv", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } } } } From 5458e90ec94efcd4e51dfaaee29cf2e8ec2a0661 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 16 Jun 2022 23:35:18 +0200 Subject: [PATCH 406/538] Fix deseq condition (back to the same as DSL1 ver) --- modules/local/deseq2_qc.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/modules/local/deseq2_qc.nf b/modules/local/deseq2_qc.nf index dcc933c4f..f9153b426 100644 --- a/modules/local/deseq2_qc.nf +++ b/modules/local/deseq2_qc.nf @@ -24,7 +24,7 @@ process DESEQ2_QC { path "versions.yml" , emit: versions script: - if (meta.multiple_groups || meta.replicates_exist) { + if (meta.multiple_groups && meta.replicates_exist) { def args = task.ext.args ?: '' def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' def antibody = meta.antibody From 7e1d4f263e5b7c982b71ffb43abeff3b87244f6b Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 16 Jun 2022 23:37:28 +0200 Subject: [PATCH 407/538] Make sure fmeta are local inside map --- workflows/chipseq.nf | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 29e2fc3b1..919791cec 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -238,7 +238,7 @@ workflow CHIPSEQ { ch_genome_bam .map { meta, bam -> - fmeta = meta.findAll { it.key != 'read_group' } + def fmeta = meta.findAll { it.key != 'read_group' } fmeta.id = fmeta.id.split('_')[0..-2].join('_') [ fmeta, bam ] } .groupTuple(by: [0]) @@ -521,7 +521,7 @@ workflow CHIPSEQ { .dump() .map { it -> - fmeta = it[1] + def fmeta = it[1] fmeta['id'] = it[3]['id'] fmeta['replicates_exist'] = it[3]['replicates_exist'] fmeta['multiple_groups'] = it[3]['multiple_groups'] From d33d5573ce69c81d78ddc41e0a9e6d09e91915b2 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 23 Jun 2022 11:38:56 +0200 Subject: [PATCH 408/538] Make fasta available for igv --- subworkflows/local/prepare_genome.nf | 13 +++++++++++++ 1 file changed, 13 insertions(+) diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index 32dd3e585..c8f76a0cf 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -43,6 +43,19 @@ workflow PREPARE_GENOME { ch_fasta = file(params.fasta) } + // Make fasta file available if reference saved or IGV is run + if (params.save_reference || !params.skip_igv) { + // log.info "test\n===============culo\n===============culo\n===============culo\n===============culo\n===============culo\n" + file("${params.outdir}/genome/").mkdirs() + ch_fasta.copyTo("${params.outdir}/genome/") + } + // else { + // log.info "pedo\n===============pedo\n===============pedo\n================pedo\n===============pedo\n===============pedo\n" + // } + // ch_fasta.subscribe { + // it.copyTo("${params.outdir}/genome/") + // } + // // Uncompress GTF annotation file or create from GFF3 if required // From 59a07d9c9ffa0546cfc8ac2d235ce1fba12dc4e2 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 23 Jun 2022 11:42:20 +0200 Subject: [PATCH 409/538] Get rid of testing code --- subworkflows/local/prepare_genome.nf | 7 ------- 1 file changed, 7 deletions(-) diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index c8f76a0cf..342465697 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -45,16 +45,9 @@ workflow PREPARE_GENOME { // Make fasta file available if reference saved or IGV is run if (params.save_reference || !params.skip_igv) { - // log.info "test\n===============culo\n===============culo\n===============culo\n===============culo\n===============culo\n" file("${params.outdir}/genome/").mkdirs() ch_fasta.copyTo("${params.outdir}/genome/") } - // else { - // log.info "pedo\n===============pedo\n===============pedo\n================pedo\n===============pedo\n===============pedo\n" - // } - // ch_fasta.subscribe { - // it.copyTo("${params.outdir}/genome/") - // } // // Uncompress GTF annotation file or create from GFF3 if required From 7c50dfdd3a4ab56fa7bcb68a04901684055e73bb Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 28 Jun 2022 00:00:58 +0200 Subject: [PATCH 410/538] Remove ch_markduplicates_multiqc since is directly reported as MARK_DUPLICATES_PICARD.out.metrics.collect{it[1]}.ifEmpty([]) --- workflows/chipseq.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 919791cec..9aee6cb1b 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -253,10 +253,10 @@ workflow CHIPSEQ { // // SUBWORKFLOW: Mark duplicates & filter BAM files after merging // - ch_markduplicates_multiqc = Channel.empty() MARK_DUPLICATES_PICARD ( PICARD_MERGESAMFILES.out.bam ) + ch_versions = ch_versions.mix(MARK_DUPLICATES_PICARD.out.versions) // // SUBWORKFLOW: Fix getting name sorted BAM here for PE/SE From a2bd7e2c313ac370639df3d61560a6ad8a1a4fa2 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 28 Jun 2022 00:02:33 +0200 Subject: [PATCH 411/538] Remove prefix since is not used in samtools_index --- conf/modules.config | 1 - 1 file changed, 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index af24b735c..8a8ec8b33 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -310,7 +310,6 @@ process { } withName: '.*:MARK_DUPLICATES_PICARD:SAMTOOLS_INDEX' { - ext.prefix = { "${meta.id}.mkD.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: params.publish_dir_mode, From 34cdc2f4f2ff4b10cc5f744dc862fc87f2256e65 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 28 Jun 2022 08:34:50 +0200 Subject: [PATCH 412/538] Move macs2_consensus "when" to modules.config --- conf/modules.config | 1 + modules/local/macs2_consensus.nf | 2 +- 2 files changed, 2 insertions(+), 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index 8a8ec8b33..2744e0ed4 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -598,6 +598,7 @@ if (params.macs_gsize) { if (!params.skip_consensus_peaks) { process { withName: 'MACS2_CONSENSUS' { + ext.when = { meta.multiple_groups || meta.replicates_exist } ext.prefix = { "${meta.id}.consensus_peaks" } publishDir = [ path: { [ diff --git a/modules/local/macs2_consensus.nf b/modules/local/macs2_consensus.nf index cd27807f1..f28dc732e 100644 --- a/modules/local/macs2_consensus.nf +++ b/modules/local/macs2_consensus.nf @@ -22,7 +22,7 @@ process MACS2_CONSENSUS { path "versions.yml" , emit: versions when: - (meta.multiple_groups || meta.replicates_exist) + task.ext.when == null || task.ext.when script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ From d35739d6922a38289504ade2bb4f45132938c4c1 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 28 Jun 2022 10:10:41 +0200 Subject: [PATCH 413/538] Skip preseq on test config --- conf/test.config | 8 ++++++-- 1 file changed, 6 insertions(+), 2 deletions(-) diff --git a/conf/test.config b/conf/test.config index d9c938a09..fdbf74c6d 100644 --- a/conf/test.config +++ b/conf/test.config @@ -23,12 +23,16 @@ params { input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/samplesheet/v2.0/samplesheet_test.csv' // Genome references - fasta = 'https://raw.githubusercontent.com/nf-core/test-datasets/atacseq/reference/genome.fa' - gtf = 'https://raw.githubusercontent.com/nf-core/test-datasets/atacseq/reference/genes.gtf' + genome = 'hg19' + // fasta = 'https://raw.githubusercontent.com/nf-core/test-datasets/atacseq/reference/genome.fa' + // gtf = 'https://raw.githubusercontent.com/nf-core/test-datasets/atacseq/reference/genes.gtf' // Not mandatory but permits the pipeline to run through peak-calling steps macs_gsize = 1.2e7 // For speed to avoid CI time-out fingerprint_bins = 100 + + // Avoid preseq errors with test data + skip_preseq = true } From 277bd119f4747960d0059df30f7a3cea8fccb625 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 28 Jun 2022 10:53:19 +0200 Subject: [PATCH 414/538] Address review comments --- conf/test.config | 5 ++--- workflows/chipseq.nf | 6 +----- 2 files changed, 3 insertions(+), 8 deletions(-) diff --git a/conf/test.config b/conf/test.config index fdbf74c6d..a9ca58c82 100644 --- a/conf/test.config +++ b/conf/test.config @@ -23,9 +23,8 @@ params { input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/samplesheet/v2.0/samplesheet_test.csv' // Genome references - genome = 'hg19' - // fasta = 'https://raw.githubusercontent.com/nf-core/test-datasets/atacseq/reference/genome.fa' - // gtf = 'https://raw.githubusercontent.com/nf-core/test-datasets/atacseq/reference/genes.gtf' + fasta = 'https://raw.githubusercontent.com/nf-core/test-datasets/atacseq/reference/genome.fa' + gtf = 'https://raw.githubusercontent.com/nf-core/test-datasets/atacseq/reference/genes.gtf' // Not mandatory but permits the pipeline to run through peak-calling steps macs_gsize = 1.2e7 diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 9aee6cb1b..7c7862728 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -486,7 +486,7 @@ workflow CHIPSEQ { meta.replicates_exist = groups.max { groups.value }.value > 1 [ meta, peaks ] } .set { ch_antibody_peaks } - // ch_antibody_peaks.dump() + MACS2_CONSENSUS ( ch_antibody_peaks ) @@ -510,15 +510,11 @@ workflow CHIPSEQ { .map { meta, saf -> [ meta.id, meta, saf ] } .set { ch_ip_saf } - // ch_ip_saf.dump() - ch_ip_control_bam .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } .groupTuple() .map { it -> [ it[0], it[1][0], it[2].flatten().sort() ] } - // .dump() .join(ch_ip_saf) - .dump() .map { it -> def fmeta = it[1] From 69c8db1d7ae22a7de58b016a744668a99d949055 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 30 Jun 2022 13:23:23 +0200 Subject: [PATCH 415/538] Updated macs_gsize on igenomes and add a process to calculate it if not available --- conf/igenomes.config | 108 ++++++++-- conf/modules.config | 228 +++++++++++----------- conf/test.config | 6 +- lib/WorkflowChipseq.groovy | 4 +- lib/WorkflowMain.groovy | 15 ++ main.nf | 2 +- modules/local/khmer_uniquekmers.nf | 38 ++++ nextflow.config | 2 +- nextflow_schema.json | 33 +++- workflows/chipseq.nf | 303 +++++++++++++++-------------- 10 files changed, 455 insertions(+), 284 deletions(-) create mode 100644 modules/local/khmer_uniquekmers.nf diff --git a/conf/igenomes.config b/conf/igenomes.config index d174cd316..e18b5ebea 100644 --- a/conf/igenomes.config +++ b/conf/igenomes.config @@ -46,8 +46,15 @@ params { bed12 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/README.txt" mito_name = "MT" - macs_gsize = "1.87e9" + // macs_gsize = "1.87e9" blacklist = "${projectDir}/assets/blacklists/v2.0/GRCm38-blacklist.v2.bed" + macs_gsize = [ + "50" : 2307679482, + "75" : 2406655830, + "100" : 2466184610, + "150" : 2492306232, + "200" : 2519386924 + ] } 'TAIR10' { fasta = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Sequence/WholeGenomeFasta/genome.fa" @@ -90,7 +97,14 @@ params { gtf = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Annotation/Genes/genes.bed" mito_name = "MtDNA" - macs_gsize = "9e7" + // macs_gsize = "9e7" + macs_gsize = [ + "50" : 95159402, + "75" : 96945370, + "100" : 98259898, + "150" : 98721103, + "200" : 98672558 + ] } 'CanFam3.1' { fasta = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Sequence/WholeGenomeFasta/genome.fa" @@ -122,7 +136,14 @@ params { gtf = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Annotation/Genes/genes.bed" mito_name = "M" - macs_gsize = "1.2e8" + // macs_gsize = "1.2e8" + macs_gsize = [ + "50" : 123519388, + "75" : 124886264, + "100" : 126807034, + "150" : 126903604, + "200" : 128575605 + ] } 'EquCab2' { fasta = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Sequence/WholeGenomeFasta/genome.fa" @@ -226,7 +247,14 @@ params { gtf = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Annotation/Genes/genes.bed" mito_name = "MT" - macs_gsize = "1.2e7" + // macs_gsize = "1.2e7" + macs_gsize = [ + "50" : 11624332, + "75" : 11693438, + "100" : 11777680, + "150" : 11783749, + "200" : 11825681 + ] } 'EF2' { fasta = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Sequence/WholeGenomeFasta/genome.fa" @@ -238,7 +266,14 @@ params { bed12 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/README.txt" mito_name = "MT" - macs_gsize = "1.21e7" + // macs_gsize = "1.21e7" + macs_gsize = [ + "50" : 12190646, + "75" : 12291456, + "100" : 12346649, + "150" : 12403911, + "200" : 12442064 + ] } 'Sbi1' { fasta = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Sequence/WholeGenomeFasta/genome.fa" @@ -280,8 +315,15 @@ params { gtf = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Annotation/Genes/genes.bed" mito_name = "chrM" - macs_gsize = "2.7e9" + // macs_gsize = "2.7e9" blacklist = "${projectDir}/assets/blacklists/v3.0/hg38-blacklist.v3.bed" + macs_gsize = [ + "50" : 2701262066, + "75" : 2749859687, + "100" : 2805665311, + "150" : 2862089864, + "200" : 2892537351 + ] } 'hg19' { fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Sequence/WholeGenomeFasta/genome.fa" @@ -293,8 +335,15 @@ params { bed12 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/README.txt" mito_name = "chrM" - macs_gsize = "2.7e9" + // macs_gsize = "2.7e9" blacklist = "${projectDir}/assets/blacklists/v1.0/hg19-blacklist.v1.bed" + macs_gsize = [ + "50" : 2684219875, + "75" : 2733035409, + "100" : 2774803719, + "150" : 2824648687, + "200" : 2848794782 + ] } 'mm10' { fasta = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Sequence/WholeGenomeFasta/genome.fa" @@ -306,8 +355,15 @@ params { bed12 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/README.txt" mito_name = "chrM" - macs_gsize = "1.87e9" + // macs_gsize = "1.87e9" blacklist = "${projectDir}/assets/blacklists/v2.0/mm10-blacklist.v2.bed" + macs_gsize = [ + "50" : 2307679482, + "75" : 2406655830, + "100" : 2466184610, + "150" : 2492306232, + "200" : 2519386924 + ] } 'bosTau8' { fasta = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Sequence/WholeGenomeFasta/genome.fa" @@ -329,7 +385,14 @@ params { bed12 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/README.txt" mito_name = "chrM" - macs_gsize = "9e7" + // macs_gsize = "9e7" + macs_gsize = [ + "50" : 95156190, + "75" : 96995949, + "100" : 98287299, + "150" : 98879728, + "200" : 98769409 + ] } 'canFam3' { fasta = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Sequence/WholeGenomeFasta/genome.fa" @@ -351,7 +414,14 @@ params { gtf = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.bed" mito_name = "chrM" - macs_gsize = "1.37e9" + // macs_gsize = "1.37e9" + macs_gsize = [ + "50" : 1172895610, + "75" : 1229400206, + "100" : 1253908756, + "150" : 1285330773, + "200" : 1292538906 + ] } 'dm6' { fasta = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Sequence/WholeGenomeFasta/genome.fa" @@ -362,7 +432,14 @@ params { gtf = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Annotation/Genes/genes.bed" mito_name = "chrM" - macs_gsize = "1.2e8" + // macs_gsize = "1.2e8" + macs_gsize = [ + "50" : 123548253, + "75" : 124886264, + "100" : 126807034, + "150" : 126908682, + "200" : 128599061 + ] } 'equCab2' { fasta = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Sequence/WholeGenomeFasta/genome.fa" @@ -415,7 +492,14 @@ params { bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BismarkIndex/" readme = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Annotation/README.txt" mito_name = "chrM" - macs_gsize = "1.2e7" + // macs_gsize = "1.2e7" + macs_gsize = [ + "50" : "11624332", + "75" : "11693438", + "100" : "11777680", + "150" : "11783749", + "200" : "11825681" + ] } 'susScr3' { fasta = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Sequence/WholeGenomeFasta/genome.fa" diff --git a/conf/modules.config b/conf/modules.config index 2744e0ed4..b9d490c51 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -503,16 +503,55 @@ if (!params.skip_plot_fingerprint) { } } -if (params.macs_gsize) { +process { + withName: 'MACS2_CALLPEAK' { + ext.args = [ + '--keep-dup all', + params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}", + params.save_macs_pileup ? '--bdg --SPMR' : '', + params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '', + params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' + ].join(' ').trim() + publishDir = [ + path: { [ + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + + withName: 'FRIP_SCORE' { + ext.args = '-bed -c -f 0.20' + publishDir = [ + path: { [ + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/qc' + ].join('') }, + enabled: false + ] + } + + withName: 'MULTIQC_CUSTOM_PEAKS' { + publishDir = [ + path: { [ + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/qc' + ].join('') }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } +} + +if (!params.skip_peak_annotation) { process { - withName: 'MACS2_CALLPEAK' { - ext.args = [ - '--keep-dup all', - params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}", - params.save_macs_pileup ? '--bdg --SPMR' : '', - params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '', - params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' - ].join(' ').trim() + withName: 'HOMER_ANNOTATEPEAKS_MACS2' { + ext.args = '-gid' + // ext.prefix = 'peaks' publishDir = [ path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", @@ -522,26 +561,63 @@ if (params.macs_gsize) { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } + } + + if (!params.skip_peak_qc) { + process { + withName: 'PLOT_MACS2_QC' { + ext.args = '-o ./ -p macs2_peak' + publishDir = [ + path: { [ + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/qc' + ].join('') }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + + withName: 'PLOT_HOMER_ANNOTATEPEAKS' { + ext.args = '-o ./ -p macs2_annotatePeaks' + publishDir = [ + path: { [ + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/qc' + ].join('') }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } + } + } +} - withName: 'FRIP_SCORE' { - ext.args = '-bed -c -f 0.20' +if (!params.skip_consensus_peaks) { + process { + withName: 'MACS2_CONSENSUS' { + ext.when = { meta.multiple_groups || meta.replicates_exist } + ext.prefix = { "${meta.id}.consensus_peaks" } publishDir = [ path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/qc' + '/consensus' ].join('') }, - enabled: false + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - withName: 'MULTIQC_CUSTOM_PEAKS' { + withName: 'SUBREAD_FEATURECOUNTS' { + ext.args = '-F SAF -O --fracOverlap 0.2' publishDir = [ path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/qc' - ].join('') }, + '/consensus' + ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -550,133 +626,55 @@ if (params.macs_gsize) { if (!params.skip_peak_annotation) { process { - withName: 'HOMER_ANNOTATEPEAKS_MACS2' { + withName: 'HOMER_ANNOTATEPEAKS_CONSENSUS' { ext.args = '-gid' - // ext.prefix = 'peaks' + ext.prefix = 'consensus_peaks' publishDir = [ path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/consensus' ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } } - - if (!params.skip_peak_qc) { - process { - withName: 'PLOT_MACS2_QC' { - ext.args = '-o ./ -p macs2_peak' - publishDir = [ - path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/qc' - ].join('') }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - - withName: 'PLOT_HOMER_ANNOTATEPEAKS' { - ext.args = '-o ./ -p macs2_annotatePeaks' - publishDir = [ - path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/qc' - ].join('') }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - } - } } - if (!params.skip_consensus_peaks) { + if (!params.skip_deseq2_qc) { process { - withName: 'MACS2_CONSENSUS' { - ext.when = { meta.multiple_groups || meta.replicates_exist } - ext.prefix = { "${meta.id}.consensus_peaks" } - publishDir = [ - path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus' - ].join('') }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - - withName: 'SUBREAD_FEATURECOUNTS' { - ext.args = '-F SAF -O --fracOverlap 0.2' + withName: DESEQ2_QC { + ext.args = [ + '--id_col 1', + '--sample_suffix \'.mLb.clN.sorted.bam\'', + '--count_col 7', + params.deseq2_vst ? '--vst TRUE' : '' + ].join(' ').trim() publishDir = [ path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus' + '/consensus/deseq2' ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } } + } - if (!params.skip_peak_annotation) { - process { - withName: 'HOMER_ANNOTATEPEAKS_CONSENSUS' { - ext.args = '-gid' - ext.prefix = 'consensus_peaks' - publishDir = [ - path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus' - ].join('') }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - } - } - - if (!params.skip_deseq2_qc) { - process { - withName: DESEQ2_QC { - ext.args = [ - '--id_col 1', - '--sample_suffix \'.mLb.clN.sorted.bam\'', - '--count_col 7', - params.deseq2_vst ? '--vst TRUE' : '' - ].join(' ').trim() - publishDir = [ + if (!params.skip_igv) { + process { + withName: 'IGV' { + publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus/deseq2' + "${params.outdir}/igv", + params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } - } - } - - if (!params.skip_igv) { - process { - withName: 'IGV' { - publishDir = [ - path: { [ - "${params.outdir}/igv", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } + ] } } } diff --git a/conf/test.config b/conf/test.config index a9ca58c82..2fad3bc87 100644 --- a/conf/test.config +++ b/conf/test.config @@ -20,15 +20,13 @@ params { max_time = 6.h // Input data - input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/samplesheet/v2.0/samplesheet_test.csv' + input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/samplesheet/v2.0/samplesheet_test.csv' + read_length = 50 // Genome references fasta = 'https://raw.githubusercontent.com/nf-core/test-datasets/atacseq/reference/genome.fa' gtf = 'https://raw.githubusercontent.com/nf-core/test-datasets/atacseq/reference/genes.gtf' - // Not mandatory but permits the pipeline to run through peak-calling steps - macs_gsize = 1.2e7 - // For speed to avoid CI time-out fingerprint_bins = 100 diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index 7ad86e8c1..8593c45be 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -93,8 +93,8 @@ class WorkflowChipseq { private static void macsGsizeWarn(log) { log.warn "=============================================================================\n" + " --macs_gsize parameter has not been provided.\n" + - " MACS2 peak-calling and differential analysis will be skipped.\n" + - " Provide '--macs_gsize macs2_genome_size' to change this behaviour.\n" + + " Its value will be obtained using khmer unique-kmers.py based on the --read_length parameter.\n" + + " Provide '--macs_gsize macs2_genome_size' or --read_length to change this behaviour.\n" + "===================================================================================" } diff --git a/lib/WorkflowMain.groovy b/lib/WorkflowMain.groovy index e17aadd9d..f28972f1f 100755 --- a/lib/WorkflowMain.groovy +++ b/lib/WorkflowMain.groovy @@ -90,4 +90,19 @@ class WorkflowMain { } return val } + + // + // Get macs genome size (macs_gsize) + // + public static Integer getMacsGsize(params) { + def val = null + if (params.genomes && params.genome && params.genomes.containsKey(params.genome)) { + if (params.genomes[ params.genome ].containsKey('macs_gsize')) { + if (params.genomes[ params.genome ][ 'macs_gsize' ].containsKey(params.read_length.toString())) { + val = params.genomes[ params.genome ][ 'macs_gsize' ][ params.read_length.toString() ] + } + } + } + return val + } } diff --git a/main.nf b/main.nf index b91365fac..9baf7cb86 100755 --- a/main.nf +++ b/main.nf @@ -25,8 +25,8 @@ params.star_index = WorkflowMain.getGenomeAttribute(params, 'star') params.gtf = WorkflowMain.getGenomeAttribute(params, 'gtf') params.gff = WorkflowMain.getGenomeAttribute(params, 'gff') params.gene_bed = WorkflowMain.getGenomeAttribute(params, 'gene_bed') -params.macs_gsize = WorkflowMain.getGenomeAttribute(params, 'macs_gsize') params.blacklist = WorkflowMain.getGenomeAttribute(params, 'blacklist') +params.macs_gsize = WorkflowMain.getMacsGsize(params) /* ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ diff --git a/modules/local/khmer_uniquekmers.nf b/modules/local/khmer_uniquekmers.nf new file mode 100644 index 000000000..8ad89a628 --- /dev/null +++ b/modules/local/khmer_uniquekmers.nf @@ -0,0 +1,38 @@ +process KHMER_UNIQUEKMERS { + tag "$fasta" + label 'process_low' + + conda (params.enable_conda ? "bioconda::khmer=3.0.0a3" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/khmer:3.0.0a3--py37haa7609a_2' : + 'quay.io/biocontainers/khmer:3.0.0a3--py37haa7609a_2' }" + + input: + path fasta + val kmer_size + + output: + path "report.txt" , emit: report + path "kmers.txt" , emit: kmers + path "versions.yml", emit: versions + + when: + task.ext.when == null || task.ext.when + + script: + def args = task.ext.args ?: '' + """ + unique-kmers.py \\ + -k $kmer_size \\ + -R report.txt \\ + $args \\ + $fasta + + grep ^number report.txt | sed 's/^.*:.[[:blank:]]//g' > kmers.txt + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + khmer: \$( unique-kmers.py --version 2>&1 | grep ^khmer | sed 's/^khmer //;s/ .*\$//' ) + END_VERSIONS + """ +} diff --git a/nextflow.config b/nextflow.config index a776c52f0..511589e2c 100644 --- a/nextflow.config +++ b/nextflow.config @@ -13,6 +13,7 @@ params { seq_center = null fragment_size = 200 fingerprint_bins = 500000 + read_length = 100 // References genome = null @@ -40,7 +41,6 @@ params { // Options: Peaks narrow_peak = false broad_cutoff = 0.1 - macs_gsize = null macs_fdr = null macs_pvalue = null min_reps_consensus = 1 diff --git a/nextflow_schema.json b/nextflow_schema.json index 7429b1cbf..a3772b598 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -10,7 +10,9 @@ "type": "object", "fa_icon": "fas fa-terminal", "description": "Define where the pipeline should find input data and save output data.", - "required": ["outdir"], + "required": [ + "outdir" + ], "properties": { "input": { "type": "string", @@ -33,6 +35,19 @@ "description": "Sequencing center information to be added to read group of BAM files.", "fa_icon": "fas fa-synagogue" }, + "read_length": { + "type": "integer", + "description": "Read length to calculate macs genome size (--macs_gsize)parameter", + "fa_icon": "fas fa-chart-area", + "default": 100, + "enum": [ + 50, + 75, + 100, + 150, + 200 + ] + }, "outdir": { "type": "string", "format": "directory-path", @@ -215,7 +230,12 @@ "default": "bwa", "description": "Specifies the alignment algorithm to use - available options are 'bwa', 'bowtie2' and 'star'.", "fa_icon": "fas fa-map-signs", - "enum": ["bwa", "bowtie2", "chromap", "star"] + "enum": [ + "bwa", + "bowtie2", + "chromap", + "star" + ] }, "keep_dups": { "type": "boolean", @@ -491,7 +511,14 @@ "description": "Method used to save pipeline results to output directory.", "help_text": "The Nextflow `publishDir` option specifies which intermediate files should be saved to the output directory. This option tells the pipeline what method should be used to move these files. See [Nextflow docs](https://www.nextflow.io/docs/latest/process.html#publishdir) for details.", "fa_icon": "fas fa-copy", - "enum": ["symlink", "rellink", "link", "copy", "copyNoFollow", "move"], + "enum": [ + "symlink", + "rellink", + "link", + "copy", + "copyNoFollow", + "move" + ], "hidden": true }, "fingerprint_bins": { diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 7c7862728..f8d5f6485 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -64,6 +64,7 @@ ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering */ include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_genomecov' +include { KHMER_UNIQUEKMERS } from '../modules/local/khmer_uniquekmers' include { FRIP_SCORE } from '../modules/local/frip_score' include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' @@ -390,176 +391,186 @@ workflow CHIPSEQ { // // Call peaks // + ch_macs_gsize = Channel.empty() ch_custompeaks_frip_multiqc = Channel.empty() ch_custompeaks_count_multiqc = Channel.empty() ch_plothomerannotatepeaks_multiqc = Channel.empty() ch_subreadfeaturecounts_multiqc = Channel.empty() - if (params.macs_gsize) { - // Create channel: [ val(meta), ip_bam, control_bam ] - ch_ip_control_bam_bai - .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } - .set { ch_ip_control_bam } - - MACS2_CALLPEAK ( - ch_ip_control_bam, - params.macs_gsize + + ch_macs_gsize = params.macs_gsize + if (!params.macs_gsize) { + KHMER_UNIQUEKMERS ( + PREPARE_GENOME.out.fasta, + params.read_length ) - ch_versions = ch_versions.mix(MACS2_CALLPEAK.out.versions.first()) + ch_macs_gsize = KHMER_UNIQUEKMERS.out.kmers.map { it.text.trim() } + } - // - // Filter for MACS2 files without peaks - // - MACS2_CALLPEAK - .out - .peak - .filter { meta, peaks -> peaks.size() > 0 } - .set { ch_macs2_peaks } + // Create channel: [ val(meta), ip_bam, control_bam ] + ch_ip_control_bam_bai + .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } + .set { ch_ip_control_bam } - ch_ip_control_bam - .join(ch_macs2_peaks, by: [0]) - .map { it -> [ it[0], it[1], it[3] ] } - .set { ch_ip_peak } + MACS2_CALLPEAK ( + ch_ip_control_bam, + ch_macs_gsize + ) + ch_versions = ch_versions.mix(MACS2_CALLPEAK.out.versions.first()) - FRIP_SCORE ( - ch_ip_peak - ) - ch_versions = ch_versions.mix(FRIP_SCORE.out.versions.first()) + // + // Filter for MACS2 files without peaks + // + MACS2_CALLPEAK + .out + .peak + .filter { meta, peaks -> peaks.size() > 0 } + .set { ch_macs2_peaks } + + ch_ip_control_bam + .join(ch_macs2_peaks, by: [0]) + .map { it -> [ it[0], it[1], it[3] ] } + .set { ch_ip_peak } + FRIP_SCORE ( ch_ip_peak - .join(FRIP_SCORE.out.txt, by: [0]) - .map { it -> [ it[0], it[2], it[3] ] } - .set { ch_ip_peak_frip } - - MULTIQC_CUSTOM_PEAKS ( - ch_ip_peak_frip, - ch_peak_count_header, - ch_frip_score_header + ) + ch_versions = ch_versions.mix(FRIP_SCORE.out.versions.first()) + + ch_ip_peak + .join(FRIP_SCORE.out.txt, by: [0]) + .map { it -> [ it[0], it[2], it[3] ] } + .set { ch_ip_peak_frip } + + MULTIQC_CUSTOM_PEAKS ( + ch_ip_peak_frip, + ch_peak_count_header, + ch_frip_score_header + ) + ch_custompeaks_frip_multiqc = MULTIQC_CUSTOM_PEAKS.out.frip + ch_custompeaks_count_multiqc = MULTIQC_CUSTOM_PEAKS.out.count + + if (!params.skip_peak_annotation) { + HOMER_ANNOTATEPEAKS_MACS2 ( + ch_macs2_peaks, + PREPARE_GENOME.out.fasta, + PREPARE_GENOME.out.gtf ) - ch_custompeaks_frip_multiqc = MULTIQC_CUSTOM_PEAKS.out.frip - ch_custompeaks_count_multiqc = MULTIQC_CUSTOM_PEAKS.out.count + ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first()) + + if (!params.skip_peak_qc) { + PLOT_MACS2_QC ( + ch_macs2_peaks.collect{it[1]} + ) + ch_versions = ch_versions.mix(PLOT_MACS2_QC.out.versions) + + PLOT_HOMER_ANNOTATEPEAKS ( + HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, + ch_peak_annotation_header, + "_peaks.annotatePeaks.txt" + ) + ch_plothomerannotatepeaks_multiqc = PLOT_HOMER_ANNOTATEPEAKS.out.tsv + ch_versions = ch_versions.mix(PLOT_HOMER_ANNOTATEPEAKS.out.versions) + } + } + + // + // Consensus peaks analysis + // + if (!params.skip_consensus_peaks) { + // Create channel: [ meta , [ peaks ] ] + // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] + ch_macs2_peaks + .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } + .groupTuple() + .map { + antibody, groups, peaks -> + [ + antibody, + groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, + peaks + ] } + .map { + antibody, groups, peaks -> + def meta = [:] + meta.id = antibody + meta.multiple_groups = groups.size() > 1 + meta.replicates_exist = groups.max { groups.value }.value > 1 + [ meta, peaks ] } + .set { ch_antibody_peaks } + + MACS2_CONSENSUS ( + ch_antibody_peaks + ) + ch_versions = ch_versions.mix(MACS2_CONSENSUS.out.versions) if (!params.skip_peak_annotation) { - HOMER_ANNOTATEPEAKS_MACS2 ( - ch_macs2_peaks, + HOMER_ANNOTATEPEAKS_CONSENSUS ( + MACS2_CONSENSUS.out.bed, PREPARE_GENOME.out.fasta, PREPARE_GENOME.out.gtf ) - ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first()) - - if (!params.skip_peak_qc) { - PLOT_MACS2_QC ( - ch_macs2_peaks.collect{it[1]} - ) - ch_versions = ch_versions.mix(PLOT_MACS2_QC.out.versions) - - PLOT_HOMER_ANNOTATEPEAKS ( - HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, - ch_peak_annotation_header, - "_peaks.annotatePeaks.txt" - ) - ch_plothomerannotatepeaks_multiqc = PLOT_HOMER_ANNOTATEPEAKS.out.tsv - ch_versions = ch_versions.mix(PLOT_HOMER_ANNOTATEPEAKS.out.versions) - } + ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_CONSENSUS.out.versions) + // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt + // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt + } + + // Create channel: [ val(meta), ip_bam ] + MACS2_CONSENSUS + .out + .saf + .map { meta, saf -> [ meta.id, meta, saf ] } + .set { ch_ip_saf } + + ch_ip_control_bam + .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } + .groupTuple() + .map { it -> [ it[0], it[1][0], it[2].flatten().sort() ] } + .join(ch_ip_saf) + .map { + it -> + def fmeta = it[1] + fmeta['id'] = it[3]['id'] + fmeta['replicates_exist'] = it[3]['replicates_exist'] + fmeta['multiple_groups'] = it[3]['multiple_groups'] + [ fmeta, it[2], it[4] ] } + .set { ch_ip_bam } + + SUBREAD_FEATURECOUNTS ( + ch_ip_bam + ) + ch_subreadfeaturecounts_multiqc = SUBREAD_FEATURECOUNTS.out.summary + ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first()) + + if (!params.skip_deseq2_qc) { + DESEQ2_QC ( + SUBREAD_FEATURECOUNTS.out.counts, + ch_deseq2_pca_header, + ch_deseq2_clustering_header + ) } // - // Consensus peaks analysis + // Create IGV session // - if (!params.skip_consensus_peaks) { - // Create channel: [ meta , [ peaks ] ] - // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] - ch_macs2_peaks - .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } - .groupTuple() - .map { - antibody, groups, peaks -> - [ - antibody, - groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, - peaks - ] } - .map { - antibody, groups, peaks -> - def meta = [:] - meta.id = antibody - meta.multiple_groups = groups.size() > 1 - meta.replicates_exist = groups.max { groups.value }.value > 1 - [ meta, peaks ] } - .set { ch_antibody_peaks } - - MACS2_CONSENSUS ( - ch_antibody_peaks - ) - ch_versions = ch_versions.mix(MACS2_CONSENSUS.out.versions) - - if (!params.skip_peak_annotation) { - HOMER_ANNOTATEPEAKS_CONSENSUS ( - MACS2_CONSENSUS.out.bed, - PREPARE_GENOME.out.fasta, - PREPARE_GENOME.out.gtf - ) - ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_CONSENSUS.out.versions) - // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt - // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt - } - - // Create channel: [ val(meta), ip_bam ] - MACS2_CONSENSUS - .out - .saf - .map { meta, saf -> [ meta.id, meta, saf ] } - .set { ch_ip_saf } - - ch_ip_control_bam - .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } - .groupTuple() - .map { it -> [ it[0], it[1][0], it[2].flatten().sort() ] } - .join(ch_ip_saf) - .map { - it -> - def fmeta = it[1] - fmeta['id'] = it[3]['id'] - fmeta['replicates_exist'] = it[3]['replicates_exist'] - fmeta['multiple_groups'] = it[3]['multiple_groups'] - [ fmeta, it[2], it[4] ] } - .set { ch_ip_bam } - - SUBREAD_FEATURECOUNTS ( - ch_ip_bam + if (!params.skip_igv) { + IGV ( + PREPARE_GENOME.out.fasta, + UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), + ch_macs2_peaks.collect{it[1]}.ifEmpty([]), + MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), + "bwa/mergedLibrary/bigwig", + { ["bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + { ["bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') } ) - ch_subreadfeaturecounts_multiqc = SUBREAD_FEATURECOUNTS.out.summary - ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first()) - - if (!params.skip_deseq2_qc) { - DESEQ2_QC ( - SUBREAD_FEATURECOUNTS.out.counts, - ch_deseq2_pca_header, - ch_deseq2_clustering_header - ) - } - - // - // Create IGV session - // - if (!params.skip_igv) { - IGV ( - PREPARE_GENOME.out.fasta, - UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), - ch_macs2_peaks.collect{it[1]}.ifEmpty([]), - MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), - "bwa/mergedLibrary/bigwig", - { ["bwa/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, - { ["bwa/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') } - ) - ch_versions = ch_versions.mix(IGV.out.versions) - } + ch_versions = ch_versions.mix(IGV.out.versions) } } + // // MODULE: Pipeline reporting // From 329ba7a25348aa60992eb41203893e17ba002b82 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 30 Jun 2022 14:39:38 +0200 Subject: [PATCH 416/538] prettier and schema do not like each other --- nextflow_schema.json | 28 ++++------------------------ 1 file changed, 4 insertions(+), 24 deletions(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index a3772b598..abfc9a6e2 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -10,9 +10,7 @@ "type": "object", "fa_icon": "fas fa-terminal", "description": "Define where the pipeline should find input data and save output data.", - "required": [ - "outdir" - ], + "required": ["outdir"], "properties": { "input": { "type": "string", @@ -40,13 +38,7 @@ "description": "Read length to calculate macs genome size (--macs_gsize)parameter", "fa_icon": "fas fa-chart-area", "default": 100, - "enum": [ - 50, - 75, - 100, - 150, - 200 - ] + "enum": [50, 75, 100, 150, 200] }, "outdir": { "type": "string", @@ -230,12 +222,7 @@ "default": "bwa", "description": "Specifies the alignment algorithm to use - available options are 'bwa', 'bowtie2' and 'star'.", "fa_icon": "fas fa-map-signs", - "enum": [ - "bwa", - "bowtie2", - "chromap", - "star" - ] + "enum": ["bwa", "bowtie2", "chromap", "star"] }, "keep_dups": { "type": "boolean", @@ -511,14 +498,7 @@ "description": "Method used to save pipeline results to output directory.", "help_text": "The Nextflow `publishDir` option specifies which intermediate files should be saved to the output directory. This option tells the pipeline what method should be used to move these files. See [Nextflow docs](https://www.nextflow.io/docs/latest/process.html#publishdir) for details.", "fa_icon": "fas fa-copy", - "enum": [ - "symlink", - "rellink", - "link", - "copy", - "copyNoFollow", - "move" - ], + "enum": ["symlink", "rellink", "link", "copy", "copyNoFollow", "move"], "hidden": true }, "fingerprint_bins": { From 58c2f4c90381c9a57d224f534ac22de3aca5dbe6 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 30 Jun 2022 16:08:52 +0200 Subject: [PATCH 417/538] Update previously existing macs_gsize with "read_length hashes" --- conf/igenomes.config | 28 ++++++++++++++-------------- 1 file changed, 14 insertions(+), 14 deletions(-) diff --git a/conf/igenomes.config b/conf/igenomes.config index e18b5ebea..addb5a7d7 100644 --- a/conf/igenomes.config +++ b/conf/igenomes.config @@ -21,8 +21,14 @@ params { bed12 = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Homo_sapiens/Ensembl/GRCh37/Annotation/README.txt" mito_name = "MT" - macs_gsize = "2.7e9" blacklist = "${projectDir}/assets/blacklists/v1.0/GRCh37-blacklist.v1.bed" + macs_gsize = [ + "50" : 2684219875, + "75" : 2733035409, + "100" : 2774803719, + "150" : 2824648687, + "200" : 2848794782 + ] } 'GRCh38' { fasta = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Sequence/WholeGenomeFasta/genome.fa" @@ -33,8 +39,14 @@ params { gtf = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Homo_sapiens/NCBI/GRCh38/Annotation/Genes/genes.bed" mito_name = "chrM" - macs_gsize = "2.7e9" blacklist = "${projectDir}/assets/blacklists/v3.0/hg38-blacklist.v3.bed" + macs_gsize = [ + "50" : 2701262066, + "75" : 2749859687, + "100" : 2805665311, + "150" : 2862089864, + "200" : 2892537351 + ] } 'GRCm38' { fasta = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Sequence/WholeGenomeFasta/genome.fa" @@ -46,7 +58,6 @@ params { bed12 = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Mus_musculus/Ensembl/GRCm38/Annotation/README.txt" mito_name = "MT" - // macs_gsize = "1.87e9" blacklist = "${projectDir}/assets/blacklists/v2.0/GRCm38-blacklist.v2.bed" macs_gsize = [ "50" : 2307679482, @@ -97,7 +108,6 @@ params { gtf = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Annotation/Genes/genes.bed" mito_name = "MtDNA" - // macs_gsize = "9e7" macs_gsize = [ "50" : 95159402, "75" : 96945370, @@ -136,7 +146,6 @@ params { gtf = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Annotation/Genes/genes.bed" mito_name = "M" - // macs_gsize = "1.2e8" macs_gsize = [ "50" : 123519388, "75" : 124886264, @@ -247,7 +256,6 @@ params { gtf = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Annotation/Genes/genes.bed" mito_name = "MT" - // macs_gsize = "1.2e7" macs_gsize = [ "50" : 11624332, "75" : 11693438, @@ -266,7 +274,6 @@ params { bed12 = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Schizosaccharomyces_pombe/Ensembl/EF2/Annotation/README.txt" mito_name = "MT" - // macs_gsize = "1.21e7" macs_gsize = [ "50" : 12190646, "75" : 12291456, @@ -315,7 +322,6 @@ params { gtf = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Annotation/Genes/genes.bed" mito_name = "chrM" - // macs_gsize = "2.7e9" blacklist = "${projectDir}/assets/blacklists/v3.0/hg38-blacklist.v3.bed" macs_gsize = [ "50" : 2701262066, @@ -335,7 +341,6 @@ params { bed12 = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Homo_sapiens/UCSC/hg19/Annotation/README.txt" mito_name = "chrM" - // macs_gsize = "2.7e9" blacklist = "${projectDir}/assets/blacklists/v1.0/hg19-blacklist.v1.bed" macs_gsize = [ "50" : 2684219875, @@ -355,7 +360,6 @@ params { bed12 = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Mus_musculus/UCSC/mm10/Annotation/README.txt" mito_name = "chrM" - // macs_gsize = "1.87e9" blacklist = "${projectDir}/assets/blacklists/v2.0/mm10-blacklist.v2.bed" macs_gsize = [ "50" : 2307679482, @@ -385,7 +389,6 @@ params { bed12 = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Annotation/README.txt" mito_name = "chrM" - // macs_gsize = "9e7" macs_gsize = [ "50" : 95156190, "75" : 96995949, @@ -414,7 +417,6 @@ params { gtf = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Annotation/Genes/genes.bed" mito_name = "chrM" - // macs_gsize = "1.37e9" macs_gsize = [ "50" : 1172895610, "75" : 1229400206, @@ -432,7 +434,6 @@ params { gtf = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Drosophila_melanogaster/UCSC/dm6/Annotation/Genes/genes.bed" mito_name = "chrM" - // macs_gsize = "1.2e8" macs_gsize = [ "50" : 123548253, "75" : 124886264, @@ -492,7 +493,6 @@ params { bismark = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/BismarkIndex/" readme = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Annotation/README.txt" mito_name = "chrM" - // macs_gsize = "1.2e7" macs_gsize = [ "50" : "11624332", "75" : "11693438", From 420d05744609cacd9aec00fab49f8d0f0b27cad9 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 30 Jun 2022 16:09:01 +0200 Subject: [PATCH 418/538] Update changelog --- CHANGELOG.md | 3 +++ 1 file changed, 3 insertions(+) diff --git a/CHANGELOG.md b/CHANGELOG.md index 6928ed449..d9a01b634 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -19,6 +19,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 - Update `igenomes.config` to fetch whole `BWAIndex/version0.6.0/` folder - [[228](https://github.com/nf-core/chipseq/issues/228)] - Update blacklist bed files. - [nf-core/tools#1415](https://github.com/nf-core/tools/issues/1415) - Make `--outdir` a mandatory parameter +- [[282](https://github.com/nf-core/chipseq/issues/282)] - Fix `genome.fa` publication for IGV. +- [[280](https://github.com/nf-core/chipseq/issues/280)] - Update `macs_gsizes` on the `igenomes.config`, create a new `--read_length` parameter and implement the logic to calculate `macs_gsizes` when the parameter is missing. ### Parameters @@ -30,6 +32,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 | | `--aligner` | | | `--save_unaligned` | | `--skip_diff_analysis` | `--skip_deseq2_qc` | +| | `--read_length` | > **NB:** Parameter has been **updated** if both old and new parameter information is present. > **NB:** Parameter has been **added** if just the new parameter information is present. From 4a73a2009fae78e9a8cab29701fa193ce7923d86 Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Thu, 30 Jun 2022 16:50:01 +0200 Subject: [PATCH 419/538] Update CHANGELOG.md Co-authored-by: Harshil Patel --- CHANGELOG.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index d9a01b634..953213af5 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -20,7 +20,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 - [[228](https://github.com/nf-core/chipseq/issues/228)] - Update blacklist bed files. - [nf-core/tools#1415](https://github.com/nf-core/tools/issues/1415) - Make `--outdir` a mandatory parameter - [[282](https://github.com/nf-core/chipseq/issues/282)] - Fix `genome.fa` publication for IGV. -- [[280](https://github.com/nf-core/chipseq/issues/280)] - Update `macs_gsizes` on the `igenomes.config`, create a new `--read_length` parameter and implement the logic to calculate `macs_gsizes` when the parameter is missing. +- [[280](https://github.com/nf-core/chipseq/issues/280)] - Update `macs_gsize` in `igenomes.config`, create a new `--read_length` parameter and implement the logic to calculate `--macs_gsize` when the parameter is missing. ### Parameters From a3289a5ad0be5ea8d8cae6e006ddf2fc175b24f6 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 30 Jun 2022 17:39:53 +0200 Subject: [PATCH 420/538] Install khmer uniquekmers as a nf-core module --- modules.json | 3 ++ .../modules/khmer/uniquekmers/main.nf} | 0 .../modules/khmer/uniquekmers/meta.yml | 42 +++++++++++++++++++ workflows/chipseq.nf | 2 +- 4 files changed, 46 insertions(+), 1 deletion(-) rename modules/{local/khmer_uniquekmers.nf => nf-core/modules/khmer/uniquekmers/main.nf} (100%) create mode 100644 modules/nf-core/modules/khmer/uniquekmers/meta.yml diff --git a/modules.json b/modules.json index 9a2a18374..f4a8aeac4 100644 --- a/modules.json +++ b/modules.json @@ -51,6 +51,9 @@ "homer/annotatepeaks": { "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, + "khmer/uniquekmers": { + "git_sha": "82fdff4fb4ce6cafcc028a7503da835427f35352" + }, "macs2/callpeak": { "git_sha": "f0800157544a82ae222931764483331a81812012" }, diff --git a/modules/local/khmer_uniquekmers.nf b/modules/nf-core/modules/khmer/uniquekmers/main.nf similarity index 100% rename from modules/local/khmer_uniquekmers.nf rename to modules/nf-core/modules/khmer/uniquekmers/main.nf diff --git a/modules/nf-core/modules/khmer/uniquekmers/meta.yml b/modules/nf-core/modules/khmer/uniquekmers/meta.yml new file mode 100644 index 000000000..31405cc16 --- /dev/null +++ b/modules/nf-core/modules/khmer/uniquekmers/meta.yml @@ -0,0 +1,42 @@ +name: "khmer_uniquekmers" +description: +keywords: + - khmer + - k-mer + - effective genome size + +tools: + - "khmer": + description: khmer k-mer counting library + homepage: https://github.com/dib-lab/khmer + documentation: https://khmer.readthedocs.io/en/latest/ + tool_dev_url: https://github.com/dib-lab/khmer + doi: "10.12688/f1000research.6924.1" + licence: ["BSD License"] + +input: + - fasta: + type: file + description: fasta file + pattern: "*.{fa,fasta}" + - kmer_size: + type: value + description: k-mer size to use + pattern: "[0-9]+" + +output: + - report: + type: file + description: Text file containing unique-kmers.py execution report + pattern: "report.txt" + - kmers: + type: file + description: Text file containing number of kmers + pattern: "kmers.txt" + - versions: + type: file + description: File containing software versions + pattern: "versions.yml" + +authors: + - "@JoseEspinosa" diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index f8d5f6485..af46dc81a 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -64,7 +64,6 @@ ch_deseq2_clustering_header = file("$projectDir/assets/multiqc/deseq2_clustering */ include { BEDTOOLS_GENOMECOV } from '../modules/local/bedtools_genomecov' -include { KHMER_UNIQUEKMERS } from '../modules/local/khmer_uniquekmers' include { FRIP_SCORE } from '../modules/local/frip_score' include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' @@ -101,6 +100,7 @@ include { DEEPTOOLS_COMPUTEMATRIX } from '../modules/nf-core/modules/deept include { DEEPTOOLS_PLOTPROFILE } from '../modules/nf-core/modules/deeptools/plotprofile/main' include { DEEPTOOLS_PLOTHEATMAP } from '../modules/nf-core/modules/deeptools/plotheatmap/main' include { DEEPTOOLS_PLOTFINGERPRINT } from '../modules/nf-core/modules/deeptools/plotfingerprint/main' +include { KHMER_UNIQUEKMERS } from '../modules/nf-core/modules/khmer/uniquekmers/main' include { MACS2_CALLPEAK } from '../modules/nf-core/modules/macs2/callpeak/main' include { SUBREAD_FEATURECOUNTS } from '../modules/nf-core/modules/subread/featurecounts/main' include { CUSTOM_DUMPSOFTWAREVERSIONS } from '../modules/nf-core/modules/custom/dumpsoftwareversions/main' From c771d94de662e719800a3c861732a7fa32b340f0 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 30 Jun 2022 17:40:41 +0200 Subject: [PATCH 421/538] Set read_length to null and exit when param not provided --- lib/WorkflowChipseq.groovy | 6 ++++++ nextflow.config | 2 +- 2 files changed, 7 insertions(+), 1 deletion(-) diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index 8593c45be..9bdea8a91 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -28,6 +28,12 @@ class WorkflowChipseq { macsGsizeWarn(log) } + if (!params.read_length && !params.macs_gsize) { + log.error "Read length not specified! The pipeline requires either the '--read_length' parameter to be set" + + "to infer MACS2 genome size\nor to provide it with the '--macs_gsize' parameter" + System.exit(1) + } + if (params.aligner) { if (!valid_params['aligners'].contains(params.aligner)) { log.error "Invalid option: '${params.aligner}'. Valid options for '--aligner': ${valid_params['aligners'].join(', ')}." diff --git a/nextflow.config b/nextflow.config index 511589e2c..6e0603d5b 100644 --- a/nextflow.config +++ b/nextflow.config @@ -13,7 +13,7 @@ params { seq_center = null fragment_size = 200 fingerprint_bins = 500000 - read_length = 100 + read_length = null // References genome = null From a6f6e47eafc9c7780b795823746eb2e8b4a367a0 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 1 Jul 2022 08:32:59 +0200 Subject: [PATCH 422/538] Update rest of macs_gsize maps --- conf/igenomes.config | 172 ++++++++++++++++++++++++++++++++++++++++++- 1 file changed, 170 insertions(+), 2 deletions(-) diff --git a/conf/igenomes.config b/conf/igenomes.config index addb5a7d7..786cf6acf 100644 --- a/conf/igenomes.config +++ b/conf/igenomes.config @@ -77,6 +77,13 @@ params { bed12 = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Arabidopsis_thaliana/Ensembl/TAIR10/Annotation/README.txt" mito_name = "Mt" + macs_gsize = [ + "50" : 114339094, + "75" : 115317469, + "100" : 118459858, + "150" : 118504138, + "200" : 117723393 + ] } 'EB2' { fasta = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Sequence/WholeGenomeFasta/genome.fa" @@ -87,6 +94,13 @@ params { gtf = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Bacillus_subtilis_168/Ensembl/EB2/Annotation/README.txt" + macs_gsize = [ + "50" : 4150072, + "75" : 4191132, + "100" : 4198752, + "150" : 4176800, + "200" : 4197072 + ] } 'UMD3.1' { fasta = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Sequence/WholeGenomeFasta/genome.fa" @@ -98,6 +112,13 @@ params { bed12 = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Bos_taurus/Ensembl/UMD3.1/Annotation/README.txt" mito_name = "MT" + macs_gsize = [ + "50" : 2370644326, + "75" : 2480511357, + "100" : 2567220492, + "150" : 2594494201, + "200" : 2648740387 + ] } 'WBcel235' { fasta = "${params.igenomes_base}/Caenorhabditis_elegans/Ensembl/WBcel235/Sequence/WholeGenomeFasta/genome.fa" @@ -126,6 +147,13 @@ params { bed12 = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Canis_familiaris/Ensembl/CanFam3.1/Annotation/README.txt" mito_name = "MT" + macs_gsize = [ + "50" : 2237684358, + "75" : 2279860111, + "100" : 2293979635, + "150" : 2300527794, + "200" : 2313332891 + ] } 'GRCz10' { fasta = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Sequence/WholeGenomeFasta/genome.fa" @@ -136,6 +164,13 @@ params { gtf = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Danio_rerio/Ensembl/GRCz10/Annotation/Genes/genes.bed" mito_name = "MT" + macs_gsize = [ + "50" : 1172895610, + "75" : 1229400206, + "100" : 1253908756, + "150" : 1285330773, + "200" : 1292538906 + ] } 'BDGP6' { fasta = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Sequence/WholeGenomeFasta/genome.fa" @@ -147,8 +182,8 @@ params { bed12 = "${params.igenomes_base}/Drosophila_melanogaster/Ensembl/BDGP6/Annotation/Genes/genes.bed" mito_name = "M" macs_gsize = [ - "50" : 123519388, - "75" : 124886264, + "50" : 123519388, + "75" : 124886264, "100" : 126807034, "150" : 126903604, "200" : 128575605 @@ -164,6 +199,13 @@ params { bed12 = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Equus_caballus/Ensembl/EquCab2/Annotation/README.txt" mito_name = "MT" + macs_gsize = [ + "50" : 2294980416, + "75" : 2289244826, + "100" : 2334155865, + "150" : 2343297042, + "200" : 2350515523 + ] } 'EB1' { fasta = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Sequence/WholeGenomeFasta/genome.fa" @@ -174,6 +216,13 @@ params { gtf = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Escherichia_coli_K_12_DH10B/Ensembl/EB1/Annotation/README.txt" + macs_gsize = [ + "50" : 4481912, + "75" : 4485018, + "100" : 4468952, + "150" : 4489684, + "200" : 4527891 + ] } 'Galgal4' { fasta = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Sequence/WholeGenomeFasta/genome.fa" @@ -184,6 +233,13 @@ params { gtf = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Gallus_gallus/Ensembl/Galgal4/Annotation/Genes/genes.bed" mito_name = "MT" + macs_gsize = [ + "50" : 974987959, + "75" : 978772437, + "100" : 984935167, + "150" : 979442039, + "200" : 991678648 + ] } 'Gm01' { fasta = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Sequence/WholeGenomeFasta/genome.fa" @@ -194,6 +250,13 @@ params { gtf = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Glycine_max/Ensembl/Gm01/Annotation/README.txt" + macs_gsize = [ + "50" : 748112428, + "75" : 826455017, + "100" : 857283568, + "150" : 895077451, + "200" : 911783687 + ] } 'Mmul_1' { fasta = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Sequence/WholeGenomeFasta/genome.fa" @@ -205,6 +268,13 @@ params { bed12 = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Macaca_mulatta/Ensembl/Mmul_1/Annotation/README.txt" mito_name = "MT" + macs_gsize = [ + "50" : 2498932238, + "75" : 2598624693, + "100" : 2642166663, + "150" : 2661433343, + "200" : 2674888870 + ] } 'IRGSP-1.0' { fasta = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Sequence/WholeGenomeFasta/genome.fa" @@ -215,6 +285,13 @@ params { gtf = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Oryza_sativa_japonica/Ensembl/IRGSP-1.0/Annotation/Genes/genes.bed" mito_name = "Mt" + macs_gsize = [ + "50" : 322594956, + "75" : 337043804, + "100" : 345775274, + "150" : 355020671, + "200" : 363478234 + ] } 'CHIMP2.1.4' { fasta = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Sequence/WholeGenomeFasta/genome.fa" @@ -226,6 +303,13 @@ params { bed12 = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Pan_troglodytes/Ensembl/CHIMP2.1.4/Annotation/README.txt" mito_name = "MT" + macs_gsize = [ + "50" : 2576111695, + "75" : 2702821987, + "100" : 2733435831, + "150" : 2735167196, + "200" : 2738912507 + ] } 'Rnor_5.0' { fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Sequence/WholeGenomeFasta/genome.fa" @@ -236,6 +320,13 @@ params { gtf = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_5.0/Annotation/Genes/genes.bed" mito_name = "MT" + macs_gsize = [ + "50" : 2303951475, + "75" : 2367071843, + "100" : 2402745922, + "150" : 2405692811, + "200" : 2407324495 + ] } 'Rnor_6.0' { fasta = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Sequence/WholeGenomeFasta/genome.fa" @@ -246,6 +337,13 @@ params { gtf = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Rattus_norvegicus/Ensembl/Rnor_6.0/Annotation/Genes/genes.bed" mito_name = "MT" + macs_gsize = [ + "50" : 2375372135, + "75" : 2440746491, + "100" : 2480029900, + "150" : 2477334634, + "200" : 2478552171 + ] } 'R64-1-1' { fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/Ensembl/R64-1-1/Sequence/WholeGenomeFasta/genome.fa" @@ -291,6 +389,13 @@ params { gtf = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Sorghum_bicolor/Ensembl/Sbi1/Annotation/README.txt" + macs_gsize = [ + "50" : 444102512, + "75" : 506986021, + "100" : 540037446, + "150" : 575130820, + "200" : 595857042 + ] } 'Sscrofa10.2' { fasta = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Sequence/WholeGenomeFasta/genome.fa" @@ -302,6 +407,13 @@ params { bed12 = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Sus_scrofa/Ensembl/Sscrofa10.2/Annotation/README.txt" mito_name = "MT" + macs_gsize = [ + "50" : 2105185708, + "75" : 2131615607, + "100" : 2149244400, + "150" : 2189757848, + "200" : 2203893315 + ] } 'AGPv3' { fasta = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Sequence/WholeGenomeFasta/genome.fa" @@ -312,6 +424,13 @@ params { gtf = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Zea_mays/Ensembl/AGPv3/Annotation/Genes/genes.bed" mito_name = "Mt" + macs_gsize = [ + "50" : 1113453752, + "75" : 1392458449, + "100" : 1579923466, + "150" : 1729475311, + "200" : 1841419596 + ] } 'hg38' { fasta = "${params.igenomes_base}/Homo_sapiens/UCSC/hg38/Sequence/WholeGenomeFasta/genome.fa" @@ -378,6 +497,13 @@ params { gtf = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Bos_taurus/UCSC/bosTau8/Annotation/Genes/genes.bed" mito_name = "chrM" + macs_gsize = [ + "50" : 2370644326, + "75" : 2480511357, + "100" : 2567220492, + "150" : 2594494201, + "200" : 2648740387 + ] } 'ce10' { fasta = "${params.igenomes_base}/Caenorhabditis_elegans/UCSC/ce10/Sequence/WholeGenomeFasta/genome.fa" @@ -407,6 +533,13 @@ params { bed12 = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Canis_familiaris/UCSC/canFam3/Annotation/README.txt" mito_name = "chrM" + macs_gsize = [ + "50" : 2237684358, + "75" : 2279860111, + "100" : 2293979635, + "150" : 2300527794, + "200" : 2313332891 + ] } 'danRer10' { fasta = "${params.igenomes_base}/Danio_rerio/UCSC/danRer10/Sequence/WholeGenomeFasta/genome.fa" @@ -452,6 +585,13 @@ params { bed12 = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Equus_caballus/UCSC/equCab2/Annotation/README.txt" mito_name = "chrM" + macs_gsize = [ + "50" : 2294980416, + "75" : 2289244826, + "100" : 2334155865, + "150" : 2343297042, + "200" : 2350515523 + ] } 'galGal4' { fasta = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Sequence/WholeGenomeFasta/genome.fa" @@ -463,6 +603,13 @@ params { bed12 = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Gallus_gallus/UCSC/galGal4/Annotation/README.txt" mito_name = "chrM" + macs_gsize = [ + "50" : 974987959, + "75" : 978772437, + "100" : 984935167, + "150" : 979442039, + "200" : 991678648 + ] } 'panTro4' { fasta = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Sequence/WholeGenomeFasta/genome.fa" @@ -474,6 +621,13 @@ params { bed12 = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Pan_troglodytes/UCSC/panTro4/Annotation/README.txt" mito_name = "chrM" + macs_gsize = [ + "50" : 2576111695, + "75" : 2702821987, + "100" : 2733435831, + "150" : 2735167196, + "200" : 2738912507 + ] } 'rn6' { fasta = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Sequence/WholeGenomeFasta/genome.fa" @@ -484,6 +638,13 @@ params { gtf = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Annotation/Genes/genes.gtf" bed12 = "${params.igenomes_base}/Rattus_norvegicus/UCSC/rn6/Annotation/Genes/genes.bed" mito_name = "chrM" + macs_gsize = [ + "50" : 2375372135, + "75" : 2440746491, + "100" : 2480029900, + "150" : 2477334634, + "200" : 2478552171 + ] } 'sacCer3' { fasta = "${params.igenomes_base}/Saccharomyces_cerevisiae/UCSC/sacCer3/Sequence/WholeGenomeFasta/genome.fa" @@ -511,6 +672,13 @@ params { bed12 = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/Genes/genes.bed" readme = "${params.igenomes_base}/Sus_scrofa/UCSC/susScr3/Annotation/README.txt" mito_name = "chrM" + macs_gsize = [ + "50" : 2105185708, + "75" : 2131615607, + "100" : 2149244400, + "150" : 2189757848, + "200" : 2203893315 + ] } } } From 1221e794fa6af3ca61a174dbb1bc140ddc8f084a Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 1 Jul 2022 08:50:41 +0200 Subject: [PATCH 423/538] Fix spaces --- conf/igenomes.config | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/conf/igenomes.config b/conf/igenomes.config index 786cf6acf..7f282cee1 100644 --- a/conf/igenomes.config +++ b/conf/igenomes.config @@ -23,8 +23,8 @@ params { mito_name = "MT" blacklist = "${projectDir}/assets/blacklists/v1.0/GRCh37-blacklist.v1.bed" macs_gsize = [ - "50" : 2684219875, - "75" : 2733035409, + "50" : 2684219875, + "75" : 2733035409, "100" : 2774803719, "150" : 2824648687, "200" : 2848794782 From d6f46214386d9e407b5390191bde90f1f6538594 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 6 Jul 2022 09:40:01 +0200 Subject: [PATCH 424/538] Get rid of default read_length in schema --- nextflow_schema.json | 1 - 1 file changed, 1 deletion(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index abfc9a6e2..073935e48 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -37,7 +37,6 @@ "type": "integer", "description": "Read length to calculate macs genome size (--macs_gsize)parameter", "fa_icon": "fas fa-chart-area", - "default": 100, "enum": [50, 75, 100, 150, 200] }, "outdir": { From b3badc25c2894b3799e90eafb9cde1453ccbc96e Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Wed, 6 Jul 2022 13:14:25 +0200 Subject: [PATCH 425/538] Update lib/WorkflowChipseq.groovy Co-authored-by: Harshil Patel --- lib/WorkflowChipseq.groovy | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index 9bdea8a91..068d4640f 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -99,7 +99,7 @@ class WorkflowChipseq { private static void macsGsizeWarn(log) { log.warn "=============================================================================\n" + " --macs_gsize parameter has not been provided.\n" + - " Its value will be obtained using khmer unique-kmers.py based on the --read_length parameter.\n" + + " It will be auto-calculated by 'khmer unique-kmers.py' using the '--read_length' parameter.\n" + " Provide '--macs_gsize macs2_genome_size' or --read_length to change this behaviour.\n" + "===================================================================================" } From 40f1d8f6e9f1a24be2d2134710a4d872e869f61f Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Wed, 6 Jul 2022 13:14:43 +0200 Subject: [PATCH 426/538] Update lib/WorkflowChipseq.groovy Co-authored-by: Harshil Patel --- lib/WorkflowChipseq.groovy | 3 +-- 1 file changed, 1 insertion(+), 2 deletions(-) diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index 068d4640f..422ff0ed7 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -29,8 +29,7 @@ class WorkflowChipseq { } if (!params.read_length && !params.macs_gsize) { - log.error "Read length not specified! The pipeline requires either the '--read_length' parameter to be set" + - "to infer MACS2 genome size\nor to provide it with the '--macs_gsize' parameter" + log.error "Both '--read_length' and '--macs_gsize' not specified! Please specify either to infer MACS2 genome size for peak calling." System.exit(1) } From 030ef2c48fcd46118a14006e9cd34bd60e9b28d4 Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Wed, 6 Jul 2022 13:15:11 +0200 Subject: [PATCH 427/538] Update lib/WorkflowChipseq.groovy Co-authored-by: Harshil Patel --- lib/WorkflowChipseq.groovy | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index 422ff0ed7..a072e4838 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -99,7 +99,7 @@ class WorkflowChipseq { log.warn "=============================================================================\n" + " --macs_gsize parameter has not been provided.\n" + " It will be auto-calculated by 'khmer unique-kmers.py' using the '--read_length' parameter.\n" + - " Provide '--macs_gsize macs2_genome_size' or --read_length to change this behaviour.\n" + + " Explicitly provide '--macs_gsize macs2_genome_size' to change this behaviour.\n" + "===================================================================================" } From e62830d48e7497fc88d6b2d6a43e084ec4b5dc60 Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Wed, 6 Jul 2022 13:15:30 +0200 Subject: [PATCH 428/538] Update nextflow_schema.json Co-authored-by: Harshil Patel --- nextflow_schema.json | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index 073935e48..feffbe782 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -35,7 +35,7 @@ }, "read_length": { "type": "integer", - "description": "Read length to calculate macs genome size (--macs_gsize)parameter", + "description": "Read length use to calculate MACS2 genome size for peak calling if `--macs_gsize` isn't provided.", "fa_icon": "fas fa-chart-area", "enum": [50, 75, 100, 150, 200] }, From 1a0999c740e6a0b5c7f0f7a6c2f0b4d38e46e21a Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Wed, 6 Jul 2022 12:45:27 +0100 Subject: [PATCH 429/538] Update nextflow_schema.json --- nextflow_schema.json | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index feffbe782..ed9cf2007 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -35,7 +35,7 @@ }, "read_length": { "type": "integer", - "description": "Read length use to calculate MACS2 genome size for peak calling if `--macs_gsize` isn't provided.", + "description": "Read length used to calculate MACS2 genome size for peak calling if `--macs_gsize` isn't provided.", "fa_icon": "fas fa-chart-area", "enum": [50, 75, 100, 150, 200] }, From 9f783fba987971a4002083f0ba0c7341df83e4ee Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 6 Jul 2022 14:36:43 +0200 Subject: [PATCH 430/538] Fix file naming for HOMER_ANNOTATEPEAKS_MACS2 --- conf/modules.config | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index b9d490c51..e8f169fcf 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -551,7 +551,7 @@ if (!params.skip_peak_annotation) { process { withName: 'HOMER_ANNOTATEPEAKS_MACS2' { ext.args = '-gid' - // ext.prefix = 'peaks' + ext.prefix = { "${meta.id}_peaks" } publishDir = [ path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", From b99804195607e46dadcbabce34f727b9a8c893bd Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 6 Jul 2022 16:59:55 +0200 Subject: [PATCH 431/538] Fix untar chromap --- subworkflows/local/prepare_genome.nf | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index 342465697..9c8615993 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -12,6 +12,7 @@ include { include { UNTAR as UNTAR_BWA_INDEX UNTAR as UNTAR_BOWTIE2_INDEX + UNTAR as UNTAR_CHROMAP_INDEX UNTAR as UNTAR_STAR_INDEX } from '../../modules/nf-core/modules/untar/main' include { GFFREAD } from '../../modules/nf-core/modules/gffread/main' @@ -172,7 +173,7 @@ workflow PREPARE_GENOME { if (prepare_tool_index == 'chromap') { if (params.chromap_index) { if (params.chromap_index.endsWith('.tar.gz')) { - ch_chromap_index = UNTAR ( params.chromap_index ).untar + ch_chromap_index = UNTAR_CHROMAP_INDEX ( [:], params.chromap_index ).untar.map{ it[1] } ch_versions = ch_versions.mix(UNTAR.out.versions) } else { ch_chromap_index = file(params.chromap_index) From bf5baaec68908eb830814c04a2946b78f5066033 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 6 Jul 2022 23:04:36 +0200 Subject: [PATCH 432/538] Generate IGV session regardless of consensus execution --- conf/modules.config | 24 ++++++++++++------------ modules/local/igv.nf | 5 ++--- workflows/chipseq.nf | 39 ++++++++++++++++++++------------------- 3 files changed, 34 insertions(+), 34 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index e8f169fcf..f8a125863 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -663,19 +663,19 @@ if (!params.skip_consensus_peaks) { } } } +} - if (!params.skip_igv) { - process { - withName: 'IGV' { - publishDir = [ - path: { [ - "${params.outdir}/igv", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - } +if (!params.skip_igv) { + process { + withName: 'IGV' { + publishDir = [ + path: { [ + "${params.outdir}/igv", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] } } } diff --git a/modules/local/igv.nf b/modules/local/igv.nf index 0cf01511a..8578092b4 100644 --- a/modules/local/igv.nf +++ b/modules/local/igv.nf @@ -16,7 +16,6 @@ process IGV { val bigwig_publish_dir val peak_publish_dir val consensus_publish_dir - // path differential_peaks from ch_macs_consensus_deseq_comp_igv.collect().ifEmpty([]) output: path "*files.txt" , emit: txt @@ -27,6 +26,8 @@ process IGV { """ find * -type l -name "*.bigWig" -exec echo -e ""{}"\\t0,0,178" \\; > bigwig.igv.txt find * -type l -name "*Peak" -exec echo -e ""{}"\\t0,0,178" \\; > peaks.igv.txt + # Avoid error when consensus not produced + find * -type l -name "*.bed" -exec echo -e ""{}"\\t0,0,178" \\; | { grep "^$consensus_publish_dir" || test \$? = 1; } > bed.igv.txt cat *.txt > igv_files.txt igv_files_to_session.py igv_session.xml igv_files.txt ../../genome/${fasta.getName()} --path_prefix '../../' @@ -37,5 +38,3 @@ process IGV { END_VERSIONS """ } -// find * -type f -name "${prefix}.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/"{}"\\t0,0,0" \\; > ${prefix}.bed.igv.txt -// find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${PEAK_TYPE}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index af46dc81a..7db9f9016 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -548,29 +548,30 @@ workflow CHIPSEQ { ch_deseq2_clustering_header ) } + } - // - // Create IGV session - // - if (!params.skip_igv) { - IGV ( - PREPARE_GENOME.out.fasta, - UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), - ch_macs2_peaks.collect{it[1]}.ifEmpty([]), - MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), - "bwa/mergedLibrary/bigwig", - { ["bwa/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, - { ["bwa/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') } - ) - ch_versions = ch_versions.mix(IGV.out.versions) - } + // + // Create IGV session + // + if (!params.skip_igv) { + IGV ( + PREPARE_GENOME.out.fasta, + UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), + ch_macs2_peaks.collect{it[1]}.ifEmpty([]), + MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), + "bwa/mergedLibrary/bigwig", + { ["bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + { ["bwa/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') } + ) + ch_versions = ch_versions.mix(IGV.out.versions) } + // // MODULE: Pipeline reporting // From b55decebe932a400fdbdc940d34cc6cb3516b536 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 6 Jul 2022 23:20:36 +0200 Subject: [PATCH 433/538] Move deseq2_qc condition to ext.when modules config --- conf/modules.config | 1 + modules/local/deseq2_qc.nf | 58 ++++++++++++++++++-------------------- 2 files changed, 29 insertions(+), 30 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index f8a125863..2d0e60456 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -645,6 +645,7 @@ if (!params.skip_consensus_peaks) { if (!params.skip_deseq2_qc) { process { withName: DESEQ2_QC { + ext.when = { "${meta.multiple_groups} && ${meta.replicates_exist}" } ext.args = [ '--id_col 1', '--sample_suffix \'.mLb.clN.sorted.bam\'', diff --git a/modules/local/deseq2_qc.nf b/modules/local/deseq2_qc.nf index f9153b426..65afb4c7d 100644 --- a/modules/local/deseq2_qc.nf +++ b/modules/local/deseq2_qc.nf @@ -24,34 +24,32 @@ process DESEQ2_QC { path "versions.yml" , emit: versions script: - if (meta.multiple_groups && meta.replicates_exist) { - def args = task.ext.args ?: '' - def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' - def antibody = meta.antibody - def prefix = "${antibody}.consensus_peaks" - """ - deseq2_qc.r \\ - --count_file $counts \\ - --outdir ./ \\ - --outprefix $prefix \\ - --cores $task.cpus \\ - $args - - sed 's/deseq2_pca/deseq2_pca_${task.index}/g' <$deseq2_pca_header >tmp.txt - sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt - cat tmp.txt ${prefix}.pca.vals.txt > ${prefix}.pca.vals_mqc.tsv - - sed 's/deseq2_clustering/deseq2_clustering_${task.index}/g' <$deseq2_clustering_header >tmp.txt - sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt - cat tmp.txt ${prefix}.sample.dists.txt > ${prefix}.sample.dists_mqc.tsv - - find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${peak_type}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt - - cat <<-END_VERSIONS > versions.yml - "${task.process}": - r-base: \$(echo \$(R --version 2>&1) | sed 's/^.*R version //; s/ .*\$//') - bioconductor-deseq2: \$(Rscript -e "library(DESeq2); cat(as.character(packageVersion('DESeq2')))") - END_VERSIONS - """ - } + def args = task.ext.args ?: '' + def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' + def antibody = meta.antibody + def prefix = "${antibody}.consensus_peaks" + """ + deseq2_qc.r \\ + --count_file $counts \\ + --outdir ./ \\ + --outprefix $prefix \\ + --cores $task.cpus \\ + $args + + sed 's/deseq2_pca/deseq2_pca_${task.index}/g' <$deseq2_pca_header >tmp.txt + sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt + cat tmp.txt ${prefix}.pca.vals.txt > ${prefix}.pca.vals_mqc.tsv + + sed 's/deseq2_clustering/deseq2_clustering_${task.index}/g' <$deseq2_clustering_header >tmp.txt + sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt + cat tmp.txt ${prefix}.sample.dists.txt > ${prefix}.sample.dists_mqc.tsv + + find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${peak_type}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + r-base: \$(echo \$(R --version 2>&1) | sed 's/^.*R version //; s/ .*\$//') + bioconductor-deseq2: \$(Rscript -e "library(DESeq2); cat(as.character(packageVersion('DESeq2')))") + END_VERSIONS + """ } From 106419f96fd9c6447c3bec994c3c40b69fd25098 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 11 Jul 2022 17:09:51 +0200 Subject: [PATCH 434/538] Change type to avoid issue when casting to integer --- lib/WorkflowMain.groovy | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/lib/WorkflowMain.groovy b/lib/WorkflowMain.groovy index f28972f1f..916fad864 100755 --- a/lib/WorkflowMain.groovy +++ b/lib/WorkflowMain.groovy @@ -94,7 +94,7 @@ class WorkflowMain { // // Get macs genome size (macs_gsize) // - public static Integer getMacsGsize(params) { + public static Long getMacsGsize(params) { def val = null if (params.genomes && params.genome && params.genomes.containsKey(params.genome)) { if (params.genomes[ params.genome ].containsKey('macs_gsize')) { From 9e01e909ce4b5d7ec3da72796349a0f9e25e2035 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 11 Jul 2022 22:47:48 +0200 Subject: [PATCH 435/538] Do not publish khmer_uniquekmers results --- conf/modules.config | 10 ++++++++++ 1 file changed, 10 insertions(+) diff --git a/conf/modules.config b/conf/modules.config index 2d0e60456..4081c3e40 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -485,6 +485,16 @@ if (!params.skip_plot_profile) { } } +if (!params.macs_gsize) { + process { + withName: 'KHMER_UNIQUEKMERS' { + publishDir = [ + enabled: false + ] + } + } +} + if (!params.skip_plot_fingerprint) { process { withName: 'DEEPTOOLS_PLOTFINGERPRINT' { From 6becc2533789798ee4755838393dbbf63df97c68 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 12 Jul 2022 13:14:28 +0200 Subject: [PATCH 436/538] Fix paths according to dsl1 pipeline version --- conf/modules.config | 27 +++++++++++++-------------- 1 file changed, 13 insertions(+), 14 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 4081c3e40..1acd8f8bb 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -488,9 +488,7 @@ if (!params.skip_plot_profile) { if (!params.macs_gsize) { process { withName: 'KHMER_UNIQUEKMERS' { - publishDir = [ - enabled: false - ] + publishDir = [ enabled: false ] } } } @@ -524,7 +522,7 @@ process { ].join(' ').trim() publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, mode: params.publish_dir_mode, @@ -536,7 +534,7 @@ process { ext.args = '-bed -c -f 0.20' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/qc' ].join('') }, @@ -547,7 +545,7 @@ process { withName: 'MULTIQC_CUSTOM_PEAKS' { publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/qc' ].join('') }, @@ -564,7 +562,7 @@ if (!params.skip_peak_annotation) { ext.prefix = { "${meta.id}_peaks" } publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, mode: params.publish_dir_mode, @@ -579,7 +577,7 @@ if (!params.skip_peak_annotation) { ext.args = '-o ./ -p macs2_peak' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/qc' ].join('') }, @@ -592,7 +590,7 @@ if (!params.skip_peak_annotation) { ext.args = '-o ./ -p macs2_annotatePeaks' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/qc' ].join('') }, @@ -611,9 +609,10 @@ if (!params.skip_consensus_peaks) { ext.prefix = { "${meta.id}.consensus_peaks" } publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus' + '/consensus', + "/${meta.antibody}" ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } @@ -624,7 +623,7 @@ if (!params.skip_consensus_peaks) { ext.args = '-F SAF -O --fracOverlap 0.2' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus' ].join('') }, @@ -641,7 +640,7 @@ if (!params.skip_consensus_peaks) { ext.prefix = 'consensus_peaks' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus' ].join('') }, @@ -664,7 +663,7 @@ if (!params.skip_consensus_peaks) { ].join(' ').trim() publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + "${params.outdir}/${params.aligner}/mergedLibrary/macs", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus/deseq2' ].join('') }, From 07ca7be2125cc1d6a5de32ba247975639ab5901f Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 12 Jul 2022 16:54:31 +0200 Subject: [PATCH 437/538] Fix ext.when condition of deseq2_qc --- conf/modules.config | 10 ++++------ 1 file changed, 4 insertions(+), 6 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 1acd8f8bb..cd371b35a 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -485,11 +485,9 @@ if (!params.skip_plot_profile) { } } -if (!params.macs_gsize) { - process { - withName: 'KHMER_UNIQUEKMERS' { - publishDir = [ enabled: false ] - } +process { + withName: 'KHMER_UNIQUEKMERS' { + publishDir = [ enabled: false ] } } @@ -654,7 +652,7 @@ if (!params.skip_consensus_peaks) { if (!params.skip_deseq2_qc) { process { withName: DESEQ2_QC { - ext.when = { "${meta.multiple_groups} && ${meta.replicates_exist}" } + ext.when = { meta.multiple_groups && meta.replicates_exist } ext.args = [ '--id_col 1', '--sample_suffix \'.mLb.clN.sorted.bam\'', From c21ba790593aeadc6fefde97869992840b60e6f0 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 19 Jul 2022 09:15:24 +0200 Subject: [PATCH 438/538] Publish genome fa idx, include regions and chr sizes by default as in v1.2.2 --- conf/modules.config | 10 +++------- 1 file changed, 3 insertions(+), 7 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index cd371b35a..c1f8d2bb1 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -89,7 +89,6 @@ process { path: { "${params.outdir}/genome" }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, - enabled: params.save_reference ] } @@ -98,7 +97,6 @@ process { path: { "${params.outdir}/genome" }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, - enabled: params.save_reference ] } } @@ -166,16 +164,14 @@ process { ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/samtools" }, - mode: params.publish_dir_mode + enabled: false ] } withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { - ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/samtools" }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + enabled: false ] } @@ -211,7 +207,7 @@ if (params.aligner == 'bwa') { if (params.aligner == 'bowtie2') { process { withName: 'BOWTIE2_ALIGN' { - ext.args = '' + ext.args = ''` ext.prefix = { "${meta.id}.Lb" } publishDir = [ path: { "${params.outdir}/${params.aligner}/library" }, From 46d5a223c2d49975a3e1be1c137b2b8c13e03f7c Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 19 Jul 2022 10:45:14 +0200 Subject: [PATCH 439/538] Rename again macs folders as macs2 --- conf/modules.config | 18 +++++++++--------- 1 file changed, 9 insertions(+), 9 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index c1f8d2bb1..b26adfabd 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -516,7 +516,7 @@ process { ].join(' ').trim() publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, mode: params.publish_dir_mode, @@ -528,7 +528,7 @@ process { ext.args = '-bed -c -f 0.20' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/qc' ].join('') }, @@ -556,7 +556,7 @@ if (!params.skip_peak_annotation) { ext.prefix = { "${meta.id}_peaks" } publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, mode: params.publish_dir_mode, @@ -571,7 +571,7 @@ if (!params.skip_peak_annotation) { ext.args = '-o ./ -p macs2_peak' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/qc' ].join('') }, @@ -584,7 +584,7 @@ if (!params.skip_peak_annotation) { ext.args = '-o ./ -p macs2_annotatePeaks' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/qc' ].join('') }, @@ -603,7 +603,7 @@ if (!params.skip_consensus_peaks) { ext.prefix = { "${meta.id}.consensus_peaks" } publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus', "/${meta.antibody}" @@ -617,7 +617,7 @@ if (!params.skip_consensus_peaks) { ext.args = '-F SAF -O --fracOverlap 0.2' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus' ].join('') }, @@ -634,7 +634,7 @@ if (!params.skip_consensus_peaks) { ext.prefix = 'consensus_peaks' publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus' ].join('') }, @@ -657,7 +657,7 @@ if (!params.skip_consensus_peaks) { ].join(' ').trim() publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus/deseq2' ].join('') }, From c67864fc8a899184f8eecd2adb217ab07e1f0535 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 19 Jul 2022 12:48:15 +0200 Subject: [PATCH 440/538] Fix typo --- conf/modules.config | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index b26adfabd..64a8cfa74 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -207,7 +207,7 @@ if (params.aligner == 'bwa') { if (params.aligner == 'bowtie2') { process { withName: 'BOWTIE2_ALIGN' { - ext.args = ''` + ext.args = '' ext.prefix = { "${meta.id}.Lb" } publishDir = [ path: { "${params.outdir}/${params.aligner}/library" }, From 647064ccfeaf270da053ad1873325b49dcfb9074 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 19 Jul 2022 13:09:08 +0200 Subject: [PATCH 441/538] Fix path --- conf/modules.config | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index 64a8cfa74..344adfc1a 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -606,7 +606,7 @@ if (!params.skip_consensus_peaks) { "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus', - "/${meta.antibody}" + "/${meta.id}" ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } From 322a7d9e2737ca26d107dc1855ae82708d010471 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 19 Jul 2022 13:12:11 +0200 Subject: [PATCH 442/538] Add read_length to test_full for retrieving macs_gsize --- conf/test_full.config | 3 +++ 1 file changed, 3 insertions(+) diff --git a/conf/test_full.config b/conf/test_full.config index de6120539..f47445a54 100644 --- a/conf/test_full.config +++ b/conf/test_full.config @@ -17,6 +17,9 @@ params { // Input data for full size test input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/samplesheet/v2.0/samplesheet_full.csv' + // Used to get macs_gsize + read_length = 50 + // Genome references genome = 'hg19' } From f69ffbd9b101cc19af3a2937cde952e85b3ab031 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 19 Jul 2022 17:31:40 +0200 Subject: [PATCH 443/538] Fix dir structure inside macs2 consensus --- conf/modules.config | 10 +++++++--- 1 file changed, 7 insertions(+), 3 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 344adfc1a..865c8316d 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -619,7 +619,8 @@ if (!params.skip_consensus_peaks) { path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus' + '/consensus', + "/${meta.id}" ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } @@ -636,7 +637,8 @@ if (!params.skip_consensus_peaks) { path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus' + '/consensus', + "/${meta.id}" ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } @@ -659,7 +661,9 @@ if (!params.skip_consensus_peaks) { path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus/deseq2' + '/consensus', + "/${meta.id}", + '/deseq2' ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } From 4ec3b2c33f203babc26afd3ea1117199cda625d8 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 20 Jul 2022 16:07:36 +0200 Subject: [PATCH 444/538] Fix file publication according to dsl1 pipeline --- conf/modules.config | 121 +++++++++++++++++++++++++------------------- 1 file changed, 70 insertions(+), 51 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 344adfc1a..e189f7003 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -65,6 +65,15 @@ process { ] } + withName: 'UNTAR_CHROMAP_INDEX|CHROMAP_INDEX' { + publishDir = [ + path: { "${params.outdir}/genome/index/chromap" }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: params.save_reference + ] + } + withName: 'GFFREAD' { ext.args = '--keep-exon-attrs -F -T' publishDir = [ @@ -88,7 +97,7 @@ process { publishDir = [ path: { "${params.outdir}/genome" }, mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } @@ -96,7 +105,7 @@ process { publishDir = [ path: { "${params.outdir}/genome" }, mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } } @@ -160,27 +169,40 @@ if (!params.skip_trimming) { } process { - withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_.*:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { ext.prefix = { "${meta.id}.Lb.sorted" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/samtools" }, - enabled: false + path: { "${params.outdir}/${params.aligner}/library" }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: params.save_align_intermeds ] } - withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_.*:BAM_SORT_SAMTOOLS:SAMTOOLS_INDEX' { publishDir = [ - path: { "${params.outdir}/${params.aligner}/samtools" }, - enabled: false + path: { "${params.outdir}/${params.aligner}/library" }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: params.save_align_intermeds ] } - withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:SAMTOOLS_.*' { - ext.prefix = { "${meta.id}.Lb.sorted" } + // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:SAMTOOLS_.*' { + // ext.prefix = { "${meta.id}.Lb.sorted" } + // publishDir = [ + // path: { "${params.outdir}/${params.aligner}/library/samtools_stats" }, + // mode: params.publish_dir_mode, + // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + // ] + // } + + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_.*:BAM_SORT_SAMTOOLS::BAM_STATS_SAMTOOLS:SAMTOOLS_.*' { publishDir = [ - path: { "${params.outdir}/${params.aligner}/library/samtools_stats" }, + path: { "${params.outdir}/${params.aligner}/library/samtools_stats/" }, mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: params.save_align_intermeds ] } } @@ -195,11 +217,13 @@ if (params.aligner == 'bwa') { ].join(' ').trim() } ext.args2 = '-bhS -F 0x0100 -O BAM' ext.prefix = { "${meta.id}.Lb" } - publishDir = [ - path: { "${params.outdir}/${params.aligner}/library" }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] + // publishDir = [ + // path: { "${params.outdir}/${params.aligner}/library" }, + // mode: params.publish_dir_mode, + // saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + // enabled: params.save_align_intermeds + // ] + publishDir = [ enabled: false ] } } } @@ -209,16 +233,17 @@ if (params.aligner == 'bowtie2') { withName: 'BOWTIE2_ALIGN' { ext.args = '' ext.prefix = { "${meta.id}.Lb" } - publishDir = [ - path: { "${params.outdir}/${params.aligner}/library" }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] + // publishDir = [ + // path: { "${params.outdir}/${params.aligner}/library" }, + // mode: params.publish_dir_mode, + // saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + // enabled: params.save_align_intermeds + // ] + publishDir = [ enabled: false ] } } } - if (params.aligner == 'chromap') { process { withName: CHROMAP_INDEX { @@ -235,7 +260,8 @@ if (params.aligner == 'chromap') { publishDir = [ path: { "${params.outdir}/${params.aligner}/library" }, mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: params.save_align_intermeds ] } } @@ -310,6 +336,7 @@ process { path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: params.publish_dir_mode, pattern: '*.{bai,csi}' + // pattern: '*.{bam,bai,csi}' //TODO ] } @@ -321,12 +348,15 @@ process { ] } + //TODO + // Should only be published when paired end data is used and save_align_intermeds is true withName: 'BAM_FILTER' { - ext.prefix = { "${meta.id}.mLb.flT.sorted" } + // ext.prefix = { "${meta.id}.mLb.flT.sorted" } + ext.prefix = { meta.single_end ? "${meta.id}.mLb.test" : "${meta.id}.mLb.flT.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + pattern: '*.mLb.flT.sorted.bam', enabled: params.save_align_intermeds ] } @@ -334,11 +364,7 @@ process { withName: 'BAM_REMOVE_ORPHANS' { ext.args = '--only_fr_pairs' ext.prefix = { "${meta.id}.mLb.clN" } - publishDir = [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] + publishDir = [ enabled: false ] } withName: 'NFCORE_CHIPSEQ:CHIPSEQ:FILTER_BAM_BAMTOOLS:BAM_SORT_SAMTOOLS:SAMTOOLS_SORT' { @@ -346,7 +372,7 @@ process { publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: params.publish_dir_mode, - pattern: '*.{bai,csi}' + pattern: '*.bam' ] } @@ -355,7 +381,7 @@ process { publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: params.publish_dir_mode, - pattern: "*.bam" + pattern: '*.{bai,csi}' ] } @@ -387,29 +413,20 @@ process { } withName: 'BEDTOOLS_GENOMECOV' { - ext.prefix = { "${meta.id}.mLb.clN" } + ext.prefix = { "${meta.id}" } publishDir = [ - [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig" }, - mode: params.publish_dir_mode, - pattern: "*.bigWig" - ], - [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig/scale" }, - mode: params.publish_dir_mode, - pattern: "*.txt" - ] + path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig/scale" }, + mode: params.publish_dir_mode, + pattern: "*.txt" ] } withName: 'UCSC_BEDGRAPHTOBIGWIG' { - ext.prefix = { "${meta.id}.mLb.clN" } + ext.prefix = { "${meta.id}" } publishDir = [ - [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig" }, - mode: params.publish_dir_mode, - pattern: "*.bigWig" - ] + path: { "${params.outdir}/${params.aligner}/mergedLibrary/bigwig" }, + mode: params.publish_dir_mode, + pattern: "*.bigWig" ] } } @@ -659,7 +676,9 @@ if (!params.skip_consensus_peaks) { path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus/deseq2' + '/consensus', + "/${meta.id}", + '/deseq2' ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } From 381636a9dd0d8e4d1cce3925461608468016ad99 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 20 Jul 2022 16:36:08 +0200 Subject: [PATCH 445/538] Fix indent --- conf/modules.config | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 9369fca58..3d7311062 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -637,7 +637,7 @@ if (!params.skip_consensus_peaks) { "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus', - "/${meta.id}" + "/${meta.id}" ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } @@ -655,7 +655,7 @@ if (!params.skip_consensus_peaks) { "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus', - "/${meta.id}" + "/${meta.id}" ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } From ef3d550e15324d8c51ac8ef04b1ef5272e1c7522 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 20 Jul 2022 17:27:44 +0200 Subject: [PATCH 446/538] More file publication fixes --- conf/modules.config | 9 +++------ 1 file changed, 3 insertions(+), 6 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 3d7311062..ced2cac01 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -306,13 +306,10 @@ process { withName: 'PICARD_MERGESAMFILES' { ext.args = '--SORT_ORDER coordinate --VALIDATION_STRINGENCY LENIENT --TMP_DIR tmp' ext.prefix = { "${meta.id}.mLb.sorted" } - publishDir = [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] + publishDir = [ enabled: false ] } + // TODO parece que no funciona!!! SET SAVE_ALIGN_INTERMEDS (mirar si picard metrics tb) withName: '.*:MARK_DUPLICATES_PICARD:PICARD_MARKDUPLICATES' { ext.args = '--ASSUME_SORTED true --REMOVE_DUPLICATES false --VALIDATION_STRINGENCY LENIENT --TMP_DIR tmp' ext.prefix = { "${meta.id}.mLb.mkD.sorted" } @@ -336,7 +333,7 @@ process { path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: params.publish_dir_mode, pattern: '*.{bai,csi}' - // pattern: '*.{bam,bai,csi}' //TODO + enabled: params.save_align_intermeds ] } From b077c38b5b20abe8b042580f8fdb38a929709ff8 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 20 Jul 2022 17:29:54 +0200 Subject: [PATCH 447/538] Fix tyop --- conf/modules.config | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index ced2cac01..7a6a23cad 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -332,7 +332,7 @@ process { publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: params.publish_dir_mode, - pattern: '*.{bai,csi}' + pattern: '*.{bai,csi}', enabled: params.save_align_intermeds ] } From f86d283efc3af8e67a1ed30999338780c6800008 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 20 Jul 2022 22:17:35 +0200 Subject: [PATCH 448/538] Change macs to macs2 output dir --- conf/modules.config | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index 7a6a23cad..524d4cdf1 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -553,7 +553,7 @@ process { withName: 'MULTIQC_CUSTOM_PEAKS' { publishDir = [ path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs", + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/qc' ].join('') }, From ff91222b3584bfde2ffb56f8f33a484a455ee27e Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 21 Jul 2022 08:45:08 +0200 Subject: [PATCH 449/538] Fix typo and not publish chromap bams before sorting --- conf/modules.config | 18 +++++++++++------- 1 file changed, 11 insertions(+), 7 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 524d4cdf1..0fed5bd03 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -188,6 +188,8 @@ process { ] } + // Lb.sorted in samtools_stats should be saved for save_align_intermeds, check if it is this one or not + // corresponds just after the alignment//TODO: fix this // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:SAMTOOLS_.*' { // ext.prefix = { "${meta.id}.Lb.sorted" } // publishDir = [ @@ -197,7 +199,8 @@ process { // ] // } - withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_.*:BAM_SORT_SAMTOOLS::BAM_STATS_SAMTOOLS:SAMTOOLS_.*' { + //Chromap does not find this config selector //TODO: fix this //Fixed + withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:SAMTOOLS_.*' { publishDir = [ path: { "${params.outdir}/${params.aligner}/library/samtools_stats/" }, mode: params.publish_dir_mode, @@ -257,12 +260,13 @@ if (params.aligner == 'chromap') { withName: CHROMAP_CHROMAP { ext.args = '--preset chip --SAM' ext.prefix = { "${meta.id}.Lb" } - publishDir = [ - path: { "${params.outdir}/${params.aligner}/library" }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, - enabled: params.save_align_intermeds - ] + // publishDir = [ + // path: { "${params.outdir}/${params.aligner}/library" }, + // mode: params.publish_dir_mode, + // saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + // enabled: params.save_align_intermeds + // ] + publishDir = [ enabled: false ] } } } From 07ea27fb597be1f04193382eca78f668d8ae99a1 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 21 Jul 2022 08:53:31 +0200 Subject: [PATCH 450/538] Add save_unaligned for bowtie2 --- conf/modules.config | 40 +++++++++++++++++++--------------------- 1 file changed, 19 insertions(+), 21 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 0fed5bd03..35b7ea39b 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -220,13 +220,12 @@ if (params.aligner == 'bwa') { ].join(' ').trim() } ext.args2 = '-bhS -F 0x0100 -O BAM' ext.prefix = { "${meta.id}.Lb" } - // publishDir = [ - // path: { "${params.outdir}/${params.aligner}/library" }, - // mode: params.publish_dir_mode, - // saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, - // enabled: params.save_align_intermeds - // ] - publishDir = [ enabled: false ] + publishDir = [ + path: { "${params.outdir}/${params.aligner}/library" }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: false + ] } } } @@ -236,13 +235,12 @@ if (params.aligner == 'bowtie2') { withName: 'BOWTIE2_ALIGN' { ext.args = '' ext.prefix = { "${meta.id}.Lb" } - // publishDir = [ - // path: { "${params.outdir}/${params.aligner}/library" }, - // mode: params.publish_dir_mode, - // saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, - // enabled: params.save_align_intermeds - // ] - publishDir = [ enabled: false ] + publishDir = [ + path: { "${params.outdir}/${params.aligner}/library" }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: false + ] } } } @@ -260,13 +258,12 @@ if (params.aligner == 'chromap') { withName: CHROMAP_CHROMAP { ext.args = '--preset chip --SAM' ext.prefix = { "${meta.id}.Lb" } - // publishDir = [ - // path: { "${params.outdir}/${params.aligner}/library" }, - // mode: params.publish_dir_mode, - // saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, - // enabled: params.save_align_intermeds - // ] - publishDir = [ enabled: false ] + publishDir = [ + path: { "${params.outdir}/${params.aligner}/library" }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: false + ] } } } @@ -294,6 +291,7 @@ if (params.aligner == 'star') { path: { "${params.outdir}/${params.aligner}/library" }, mode: params.publish_dir_mode, pattern: '*.bam', + enabled: false ], [ path: { "${params.outdir}/${params.aligner}/unmapped" }, From 25800a7a7107f6a39d0a55bf40ae563be452c201 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 21 Jul 2022 11:14:05 +0200 Subject: [PATCH 451/538] Add save_unaligned for bowtie2 and refactor in star --- conf/modules.config | 20 ++++++++++++++------ 1 file changed, 14 insertions(+), 6 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 35b7ea39b..02588a41c 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -236,10 +236,18 @@ if (params.aligner == 'bowtie2') { ext.args = '' ext.prefix = { "${meta.id}.Lb" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/library" }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, - enabled: false + [ + path: { "${params.outdir}/${params.aligner}/library" }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: false + ], + [ + path: { "${params.outdir}/${params.aligner}/library/unmapped" }, + mode: params.publish_dir_mode, + pattern: '*.fastq.gz', + enabled: params.save_unaligned + ] ] } } @@ -283,7 +291,7 @@ if (params.aligner == 'star') { ].join(' ').trim() publishDir = [ [ - path: { "${params.outdir}/${params.aligner}/log" }, + path: { "${params.outdir}/${params.aligner}/library/log" }, mode: params.publish_dir_mode, pattern: '*.{out,tab}' ], @@ -294,7 +302,7 @@ if (params.aligner == 'star') { enabled: false ], [ - path: { "${params.outdir}/${params.aligner}/unmapped" }, + path: { "${params.outdir}/${params.aligner}/library/unmapped" }, mode: params.publish_dir_mode, pattern: '*.fastq.gz', enabled: params.save_unaligned From ba3b171536f6ebedcf580558e4d145a19637fb2b Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 21 Jul 2022 11:34:31 +0200 Subject: [PATCH 452/538] Update output.md --- docs/output.md | 80 +++++++++++++++++++++++++++----------------------- 1 file changed, 44 insertions(+), 36 deletions(-) diff --git a/docs/output.md b/docs/output.md index c80fb81a1..f2abcb5e3 100644 --- a/docs/output.md +++ b/docs/output.md @@ -52,22 +52,45 @@ The initial QC and alignments are performed at the library-level e.g. if the sam ### Alignment +The pipeline has been written in a way where all the files generated downstream of the alignment are placed in the same directory as specified by `--aligner` e.g. if `--aligner bwa` is specified then all the downstream results will be placed in the `bwa/` directory. This helps with organising the directory structure and more importantly, allows the end-user to get the results from multiple aligners by simply re-running the pipeline with a different `--aligner` option along the `-resume` parameter. It also means that results won't be overwritten when resuming the pipeline and can be used for benchmarking between alignment algorithms if required. Thus, `` in the directory structure below corresponds to the aligner set when running the pipeline. +
Output files -- `bwa/library/` +- `/library/` - `*.bam`: The files resulting from the alignment of individual libraries are not saved by default so this directory will not be present in your results. You can override this behaviour with the use of the `--save_align_intermeds` flag in which case it will contain the coordinate sorted alignment files in [`*.bam`](https://samtools.github.io/hts-specs/SAMv1.pdf) format. -- `bwa/library/samtools_stats/` +- `/library/samtools_stats/` - SAMtools `.sorted.bam.flagstat`, `.sorted.bam.idxstats` and `.sorted.bam.stats` files generated from the alignment files. -> **NB:** File names in the resulting directory (i.e. `bwa/library/`) will have the '`.Lb.`' suffix. +> **NB:** File names in the resulting directory (i.e. `/library/`) will have the '`.Lb.`' suffix.
-Adapter-trimmed reads are mapped to the reference assembly using [BWA](http://bio-bwa.sourceforge.net/bwa.shtml). A genome index is required to run BWA so if this is not provided explicitly using the `--bwa_index` parameter then it will be created automatically from the genome fasta input. The index creation process can take a while for larger genomes so it is possible to use the `--save_reference` parameter to save the indices for future pipeline runs, reducing processing times. +Adapter-trimmed reads are mapped to the reference assembly using the aligner set by the `--aligner` parameter. Available aligners are [BWA](http://bio-bwa.sourceforge.net/bwa.shtml) (default), [Bowtie 2](http://bowtie-bio.sourceforge.net/bowtie2/index.shtml), [Chromap](https://github.com/haowenz/chromap) and [STAR](https://github.com/alexdobin/STAR). A genome index is required to run any of this aligners so if this is not provided explicitly using the corresponding parameter (e.g. `--bwa_index`), then it will be created automatically from the genome fasta input. The index creation process can take a while for larger genomes so it is possible to use the `--save_reference` parameter to save the indices for future pipeline runs, reducing processing times. ![MultiQC - SAMtools stats plot](images/mqc_samtools_stats_plot.png) +#### Unmapped reads + +The `--save_unaligned` parameter enables to obtain FastQ files containing unmapped reads (only available for STAR and Bowtie2). + +
+ Output files +- `/library/unmapped/` + - `*.fastq.gz`: If `--save_unaligned` is specified, FastQ files containing unmapped reads will be placed in this directory. + +
+ +#### STAR logs + +
+ Output files + +- `star/library/log/` + - `*.SJ.out.tab`: File containing filtered splice junctions detected after mapping the reads. + - `*.Log.final.out`: STAR alignment report containing the mapping results summary. + - `*.Log.out` and `*.Log.progress.out`: STAR log files containing detailed information about the run. Typically only useful for debugging purposes. + ## Merged library-level analysis The library-level alignments associated with the same sample are merged and subsequently used for the downstream analyses. @@ -77,19 +100,19 @@ The library-level alignments associated with the same sample are merged and subs
Output files -- `bwa/mergedLibrary/` +- `/mergedLibrary/` - `*.bam`: Merged library-level, coordinate sorted `*.bam` files after the marking of duplicates, and filtering based on various criteria. The file suffix for the final filtered files will be `*.mLb.clN.*`. If you specify the `--save_align_intermeds` parameter then two additional sets of files will be present. These represent the unfiltered alignments with duplicates marked (`*.mLb.mkD.*`), and in the case of paired-end datasets the filtered alignments before the removal of orphan read pairs (`*.mLb.flT.*`). -- `bwa/mergedLibrary/samtools_stats/` +- `/mergedLibrary/samtools_stats/` - SAMtools `*.flagstat`, `*.idxstats` and `*.stats` files generated from the alignment files. -- `bwa/mergedLibrary/picard_metrics/` +- `/mergedLibrary/picard_metrics/` - `*_metrics`: Alignment QC files from picard CollectMultipleMetrics. - `*.metrics.txt`: Metrics file from MarkDuplicates. -- `bwa/mergedLibrary/picard_metrics/pdf/` +- `/mergedLibrary/picard_metrics/pdf/` - `*.pdf`: Alignment QC plot files from picard CollectMultipleMetrics. -- `bwa/mergedLibrary/preseq/` +- `/mergedLibrary/preseq/` - `*.lc_extrap.txt`: Preseq expected future yield file. -> **NB:** File names in the resulting directory (i.e. `bwa/mergedLibrary/`) will have the '`.mLb.`' suffix. +> **NB:** File names in the resulting directory (i.e. `/mergedLibrary/`) will have the '`.mLb.`' suffix.
@@ -110,7 +133,7 @@ The [Preseq](http://smithlabresearch.org/software/preseq/) package is aimed at p
Output files -- `bwa/mergedLibrary/bigwig/` +- `/mergedLibrary/bigwig/` - `*.bigWig`: Normalised bigWig files scaled to 1 million mapped reads.
@@ -122,12 +145,12 @@ The [bigWig](https://genome.ucsc.edu/goldenpath/help/bigWig.html) format is in a
Output files -- `bwa/mergedLibrary/phantompeakqualtools/` +- `/mergedLibrary/phantompeakqualtools/` - `*.spp.out`, `*.spp.pdf`: phantompeakqualtools output files. - `*_mqc.tsv`: MultiQC custom content files. -- `bwa/mergedLibrary/deepTools/plotFingerprint/` +- `/mergedLibrary/deepTools/plotFingerprint/` - `*.plotFingerprint.pdf`, `*.plotFingerprint.qcmetrics.txt`, `*.plotFingerprint.raw.txt`: plotFingerprint output files. -- `bwa/mergedLibrary/deepTools/plotProfile/` +- `/mergedLibrary/deepTools/plotProfile/` - `*.computeMatrix.mat.gz`, `*.computeMatrix.vals.mat.tab`, `*.plotProfile.pdf`, `*.plotProfile.tab`, `*.plotHeatmap.pdf`, `*.plotHeatmap.mat.tab`: plotProfile output files.
@@ -157,10 +180,10 @@ The results from deepTools plotProfile gives you a quick visualisation for the g
Output files -- `bwa/mergedLibrary/macs2//` +- `/mergedLibrary/macs2//` - `*.xls`, `*.broadPeak` or `*.narrowPeak`, `*.gappedPeak`, `*summits.bed`: MACS2 output files - the files generated will depend on whether MACS2 has been run in _narrowPeak_ or _broadPeak_ mode. - `*.annotatePeaks.txt`: HOMER peak-to-gene annotation file. -- `bwa/mergedLibrary/macs2//qc/` +- `/mergedLibrary/macs2//qc/` - `macs_peak.plots.pdf`: QC plots for MACS2 peaks. - `macs_annotatePeaks.plots.pdf`: QC plots for peak-to-gene feature annotation. - `*.FRiP_mqc.tsv`, `*.count_mqc.tsv`, `macs_annotatePeaks.summary_mqc.tsv`: MultiQC custom-content files for FRiP score, peak count and peak-to-gene ratios. @@ -186,7 +209,7 @@ Various QC plots per sample including number of peaks, fold-change distribution,
Output files -- `bwa/mergedLibrary/macs2//consensus/` +- `/mergedLibrary/macs2//consensus/` - `*.bed`: Consensus peak-set across all samples in BED format. - `*.saf`: Consensus peak-set across all samples in SAF format. Required by featureCounts for read quantification. - `*.featureCounts.txt`: Read counts across all samples relative to consensus peak-set. @@ -214,18 +237,12 @@ The [featureCounts](http://bioinf.wehi.edu.au/featureCounts/) tool is used to co
Output files -- `bwa/mergedLibrary/macs2//consensus//deseq2/` - - `*.results.txt`: Spreadsheet containing differential binding results across all consensus peaks and all comparisons. +- `/mergedLibrary/macs2//consensus//deseq2/` + - `*.sample.dists.txt`: Spreadsheet containing sample-to-sample distance across each consensus peak. - `*.plots.pdf`: File containing PCA and hierarchical clustering plots. - - `*.log`: Log file with information for number of differentially bound intervals at different FDR and fold-change thresholds for each comparison. - `*.dds.rld.RData`: File containing R `dds` and `rld` objects generated by DESeq2. - `R_sessionInfo.log`: File containing information about R, the OS and attached or loaded packages. - - `bwa/mergedLibrary/macs2//consensus///` - - `*.results.txt`: Spreadsheet containing comparison-specific DESeq2 output for differential binding results across all peaks. - - `*FDR0.01.results.txt`, `*FDR0.05.results.txt`: Subset of above file for peaks that pass FDR <= 0.01 and FDR <= 0.05. - - `*FDR0.01.results.bed`, `*FDR0.05.results.bed`: BED files for peaks that pass FDR <= 0.01 and FDR <= 0.05. - - `*deseq2.plots.pdf`: MA, Volcano, clustering and scatterplots at FDR <= 0.01 and FDR <= 0.05. - - `bwa/mergedLibrary/macs2//consensus//sizeFactors/` + - `/mergedLibrary/macs2//consensus//sizeFactors/` - `*.txt`, `*.RData`: Files containing DESeq2 sizeFactors per sample.
@@ -238,16 +255,6 @@ This pipeline uses a standardised DESeq2 analysis script to get an idea of the r ![MultiQC - DESeq2 sample similarity plot](images/mqc_deseq2_sample_similarity_plot.png) -By default, all possible pairwise comparisons across the groups from a particular antibody (as defined in [`design.csv`](usage.md#--design)) are performed. The DESeq2 results are generated by the pipeline in various ways. You can load up the results across all of the comparisons in a single spreadsheet, or individual folders will also be created that contain the results specific to a particular comparison. For the latter, additional files will also be generated where the intervals have been pre-filtered based on a couple of standard FDR thresholds. Please see [DESeq2 output](http://bioconductor.org/packages/release/bioc/vignettes/DESeq2/inst/doc/DESeq2.html#differential-expression-analysis) for a description of the columns generated by DESeq2. - -

- R - DESeq2 MA plot -

- -

- R - DESeq2 Volcano plot -

- ## Aggregate analysis ### Present QC for the raw read, alignment, peak and differential binding results @@ -304,6 +311,7 @@ Once installed, open IGV, go to `File > Open Session` and select the `igv_sessio - `bwa/`: Directory containing BWA indices. - `bowtie2/`: Directory containing BOWTIE2 indices. + - `chromap/`: Directory containing Chromap indices. - `star/`: Directory containing STAR indices. - If the `--save_reference` parameter is provided then the alignment indices generated by the pipeline will be saved in this directory. This can be quite a time-consuming process so it permits their reuse for future runs of the pipeline or for other purposes. 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z0^B{O<8;l+-k;~~3RSOJ@S0Xr%H$L6l$UTu=SmL!{siRZ&}Rb~pCs7ZR$k(#aw3q diff --git a/modules/local/deseq2_qc.nf b/modules/local/deseq2_qc.nf index 65afb4c7d..acc4d595d 100644 --- a/modules/local/deseq2_qc.nf +++ b/modules/local/deseq2_qc.nf @@ -44,8 +44,6 @@ process DESEQ2_QC { sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt cat tmp.txt ${prefix}.sample.dists.txt > ${prefix}.sample.dists_mqc.tsv - find * -type f -name "*.FDR0.05.results.bed" -exec echo -e "bwa/mergedLibrary/macs/${peak_type}/consensus/${antibody}/deseq2/"{}"\\t255,0,0" \\; > ${prefix}.igv.txt - cat <<-END_VERSIONS > versions.yml "${task.process}": r-base: \$(echo \$(R --version 2>&1) | sed 's/^.*R version //; s/ .*\$//') From 89d5bdf8e6bdfd6cc80102df4e29e246d464fff6 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 21 Jul 2022 11:45:37 +0200 Subject: [PATCH 454/538] Change trim_galore by trimgalore in output.md --- docs/output.md | 8 ++++---- 1 file changed, 4 insertions(+), 4 deletions(-) diff --git a/docs/output.md b/docs/output.md index f2abcb5e3..8074696c6 100644 --- a/docs/output.md +++ b/docs/output.md @@ -35,13 +35,13 @@ The initial QC and alignments are performed at the library-level e.g. if the sam
Output files -- `trim_galore/` +- `trimgalore/` - `*fastq.gz`: If `--save_trimmed` is specified, FastQ files **after** adapter trimming will be placed in this directory. -- `trim_galore/logs/` +- `trimgalore/logs/` - `*.log`: Log file generated by Trim Galore!. -- `trim_galore/fastqc/` +- `trimgalore/fastqc/` - `*_fastqc.html`: FastQC report containing quality metrics for read 1 (_and read2 if paired-end_) **after** adapter trimming. -- `trim_galore/fastqc/zips/` +- `trimgalore/fastqc/zips/` - `*_fastqc.zip`: Zip archive containing the FastQC report, tab-delimited data file and plot images.
From d37edb2cdd24a42db20d5ba975d5a3b240ae5797 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 21 Jul 2022 17:04:27 +0200 Subject: [PATCH 455/538] Update modules --- conf/modules.config | 21 +--- modules.json | 29 +++-- modules/nf-core/modules/bowtie2/align/main.nf | 104 +++++++++--------- .../nf-core/modules/bowtie2/align/meta.yml | 11 ++ .../custom/dumpsoftwareversions/main.nf | 6 +- modules/nf-core/modules/gunzip/main.nf | 10 ++ .../modules/homer/annotatepeaks/main.nf | 4 +- modules/nf-core/modules/multiqc/main.nf | 43 -------- modules/nf-core/modules/multiqc/meta.yml | 40 ------- .../modules/phantompeakqualtools/main.nf | 4 +- .../picard/collectmultiplemetrics/main.nf | 10 +- .../picard/collectmultiplemetrics/meta.yml | 4 + .../modules/picard/markduplicates/main.nf | 6 +- .../modules/picard/mergesamfiles/main.nf | 6 +- .../nf-core/modules/samtools/flagstat/main.nf | 3 +- .../nf-core/modules/samtools/idxstats/main.nf | 4 +- .../nf-core/modules/samtools/stats/main.nf | 5 +- .../modules/ucsc/bedgraphtobigwig/main.nf | 4 +- modules/nf-core/modules/untar/main.nf | 8 +- subworkflows/nf-core/align_bowtie2.nf | 2 +- workflows/chipseq.nf | 3 +- 21 files changed, 130 insertions(+), 197 deletions(-) delete mode 100644 modules/nf-core/modules/multiqc/main.nf delete mode 100644 modules/nf-core/modules/multiqc/meta.yml diff --git a/conf/modules.config b/conf/modules.config index 02588a41c..36dbe73ec 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -188,19 +188,8 @@ process { ] } - // Lb.sorted in samtools_stats should be saved for save_align_intermeds, check if it is this one or not - // corresponds just after the alignment//TODO: fix this - // withName: 'NFCORE_CHIPSEQ:CHIPSEQ:.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:SAMTOOLS_.*' { - // ext.prefix = { "${meta.id}.Lb.sorted" } - // publishDir = [ - // path: { "${params.outdir}/${params.aligner}/library/samtools_stats" }, - // mode: params.publish_dir_mode, - // saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - // ] - // } - - //Chromap does not find this config selector //TODO: fix this //Fixed withName: 'NFCORE_CHIPSEQ:CHIPSEQ:ALIGN_.*:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:SAMTOOLS_.*' { + ext.prefix = { "${meta.id}.Lb.sorted.bam" } publishDir = [ path: { "${params.outdir}/${params.aligner}/library/samtools_stats/" }, mode: params.publish_dir_mode, @@ -319,7 +308,6 @@ process { publishDir = [ enabled: false ] } - // TODO parece que no funciona!!! SET SAVE_ALIGN_INTERMEDS (mirar si picard metrics tb) withName: '.*:MARK_DUPLICATES_PICARD:PICARD_MARKDUPLICATES' { ext.args = '--ASSUME_SORTED true --REMOVE_DUPLICATES false --VALIDATION_STRINGENCY LENIENT --TMP_DIR tmp' ext.prefix = { "${meta.id}.mLb.mkD.sorted" } @@ -348,6 +336,7 @@ process { } withName: '.*:MARK_DUPLICATES_PICARD:BAM_STATS_SAMTOOLS:.*' { + ext.prefix = { "${meta.id}.mLb.mkD.sorted.bam" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/samtools_stats" }, mode: params.publish_dir_mode, @@ -355,11 +344,9 @@ process { ] } - //TODO // Should only be published when paired end data is used and save_align_intermeds is true withName: 'BAM_FILTER' { - // ext.prefix = { "${meta.id}.mLb.flT.sorted" } - ext.prefix = { meta.single_end ? "${meta.id}.mLb.test" : "${meta.id}.mLb.flT.sorted" } + ext.prefix = { meta.single_end ? "${meta.id}.mLb.noPublish" : "${meta.id}.mLb.flT.sorted" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary" }, mode: params.publish_dir_mode, @@ -393,7 +380,7 @@ process { } withName: 'NFCORE_CHIPSEQ:CHIPSEQ:FILTER_BAM_BAMTOOLS:BAM_SORT_SAMTOOLS:BAM_STATS_SAMTOOLS:.*' { - ext.prefix = { "${meta.id}.mLb.clN.sorted" } + ext.prefix = { "${meta.id}.mLb.clN.sorted.bam" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/samtools_stats" }, mode: params.publish_dir_mode, diff --git a/modules.json b/modules.json index f4a8aeac4..ad30c80a2 100644 --- a/modules.json +++ b/modules.json @@ -4,7 +4,7 @@ "repos": { "nf-core/modules": { "bowtie2/align": { - "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" + "git_sha": "848ee9a215d02d80be033bfa60881700f2bd914c" }, "bowtie2/build": { "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" @@ -22,7 +22,7 @@ "git_sha": "dbb46c9b635080b132bab4b8d5b9a14f0d1c22e7" }, "custom/dumpsoftwareversions": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + "git_sha": "e5b44499efcf6f7fb24874886bac60591c5d94dd" }, "custom/getchromsizes": { "git_sha": "213403187932dbbdd936a04474cc8cd8abae7a08" @@ -46,10 +46,10 @@ "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" }, "gunzip": { - "git_sha": "9aadd9a6d3f5964476582319b3a1c54a3e3fe7c9" + "git_sha": "fa37e0662690c4ec4260dae282fbce08777503e6" }, "homer/annotatepeaks": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + "git_sha": "233fa70811a03a4cecb2ece483b5c8396e2cee1d" }, "khmer/uniquekmers": { "git_sha": "82fdff4fb4ce6cafcc028a7503da835427f35352" @@ -57,29 +57,26 @@ "macs2/callpeak": { "git_sha": "f0800157544a82ae222931764483331a81812012" }, - "multiqc": { - "git_sha": "49b18b1639f4f7104187058866a8fab33332bdfe" - }, "phantompeakqualtools": { - "git_sha": "6a46e7cf117bbae41bca9b4c7ff7a77794df16ec" + "git_sha": "233fa70811a03a4cecb2ece483b5c8396e2cee1d" }, "picard/collectmultiplemetrics": { - "git_sha": "00467ac64affbbc17b255762f10a6c8fa362aabc" + "git_sha": "682f789f93070bd047868300dd018faf3d434e7c" }, "picard/markduplicates": { - "git_sha": "20ebb89ff97a2665106be9cace5ccb9aa4eed1be" + "git_sha": "682f789f93070bd047868300dd018faf3d434e7c" }, "picard/mergesamfiles": { - "git_sha": "20ebb89ff97a2665106be9cace5ccb9aa4eed1be" + "git_sha": "682f789f93070bd047868300dd018faf3d434e7c" }, "preseq/lcextrap": { "git_sha": "7111e571cc5b6069de4673cd6165af680f17b4d7" }, "samtools/flagstat": { - "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" + "git_sha": "ecece498f10b47b7c9d06f53a310cea5811b4c5f" }, "samtools/idxstats": { - "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" + "git_sha": "ecece498f10b47b7c9d06f53a310cea5811b4c5f" }, "samtools/index": { "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" @@ -88,7 +85,7 @@ "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" }, "samtools/stats": { - "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" + "git_sha": "f48a24770e24358e58de66e9b805a70d77cd154b" }, "subread/featurecounts": { "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" @@ -97,10 +94,10 @@ "git_sha": "85ec13ff1fc2196c5a507ea497de468101baabed" }, "ucsc/bedgraphtobigwig": { - "git_sha": "e20e57f90b6787ac9a010a980cf6ea98bd990046" + "git_sha": "233fa70811a03a4cecb2ece483b5c8396e2cee1d" }, "untar": { - "git_sha": "9aadd9a6d3f5964476582319b3a1c54a3e3fe7c9" + "git_sha": "51be617b1ca9bff973655eb899d591ed6ab253b5" } } } diff --git a/modules/nf-core/modules/bowtie2/align/main.nf b/modules/nf-core/modules/bowtie2/align/main.nf index 44ce76ca0..c74e376f7 100644 --- a/modules/nf-core/modules/bowtie2/align/main.nf +++ b/modules/nf-core/modules/bowtie2/align/main.nf @@ -1,77 +1,71 @@ process BOWTIE2_ALIGN { tag "$meta.id" - label 'process_high' + label "process_high" - conda (params.enable_conda ? 'bioconda::bowtie2=2.4.4 bioconda::samtools=1.15.1 conda-forge::pigz=2.6' : null) - container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/mulled-v2-ac74a7f02cebcfcc07d8e8d1d750af9c83b4d45a:1744f68fe955578c63054b55309e05b41c37a80d-0' : - 'quay.io/biocontainers/mulled-v2-ac74a7f02cebcfcc07d8e8d1d750af9c83b4d45a:1744f68fe955578c63054b55309e05b41c37a80d-0' }" + conda (params.enable_conda ? "bioconda::bowtie2=2.4.4 bioconda::samtools=1.15.1 conda-forge::pigz=2.6" : null) + container "${ workflow.containerEngine == "singularity" && !task.ext.singularity_pull_docker_container ? + "https://depot.galaxyproject.org/singularity/mulled-v2-ac74a7f02cebcfcc07d8e8d1d750af9c83b4d45a:1744f68fe955578c63054b55309e05b41c37a80d-0" : + "quay.io/biocontainers/mulled-v2-ac74a7f02cebcfcc07d8e8d1d750af9c83b4d45a:1744f68fe955578c63054b55309e05b41c37a80d-0" }" input: tuple val(meta), path(reads) path index val save_unaligned + val sort_bam output: - tuple val(meta), path('*.bam') , emit: bam - tuple val(meta), path('*.log') , emit: log - tuple val(meta), path('*fastq.gz'), emit: fastq, optional:true + tuple val(meta), path("*.bam") , emit: bam + tuple val(meta), path("*.log") , emit: log + tuple val(meta), path("*fastq.gz"), emit: fastq, optional:true path "versions.yml" , emit: versions when: task.ext.when == null || task.ext.when script: - def args = task.ext.args ?: '' - def args2 = task.ext.args2 ?: '' + def args = task.ext.args ?: "" + def args2 = task.ext.args2 ?: "" def prefix = task.ext.prefix ?: "${meta.id}" - if (meta.single_end) { - def unaligned = save_unaligned ? "--un-gz ${prefix}.unmapped.fastq.gz" : '' - """ - INDEX=`find -L ./ -name "*.rev.1.bt2" | sed 's/.rev.1.bt2//'` - bowtie2 \\ - -x \$INDEX \\ - -U $reads \\ - --threads $task.cpus \\ - $unaligned \\ - $args \\ - 2> ${prefix}.bowtie2.log \\ - | samtools view -@ $task.cpus $args2 -bhS -o ${prefix}.bam - - cat <<-END_VERSIONS > versions.yml - "${task.process}": - bowtie2: \$(echo \$(bowtie2 --version 2>&1) | sed 's/^.*bowtie2-align-s version //; s/ .*\$//') - samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') - pigz: \$( pigz --version 2>&1 | sed 's/pigz //g' ) - END_VERSIONS - """ + def unaligned = "" + def reads_args = "" + if (meta.single_end) { + unaligned = save_unaligned ? "--un-gz ${prefix}.unmapped.fastq.gz" : "" + reads_args = "-U ${reads}" } else { - def unaligned = save_unaligned ? "--un-conc-gz ${prefix}.unmapped.fastq.gz" : '' - """ - INDEX=`find -L ./ -name "*.rev.1.bt2" | sed 's/.rev.1.bt2//'` - bowtie2 \\ - -x \$INDEX \\ - -1 ${reads[0]} \\ - -2 ${reads[1]} \\ - --threads $task.cpus \\ - $unaligned \\ - $args \\ - 2> ${prefix}.bowtie2.log \\ - | samtools view -@ $task.cpus $args2 -bhS -o ${prefix}.bam - + unaligned = save_unaligned ? "--un-conc-gz ${prefix}.unmapped.fastq.gz" : "" + reads_args = "-1 ${reads[0]} -2 ${reads[1]}" + } - if [ -f ${prefix}.unmapped.fastq.1.gz ]; then - mv ${prefix}.unmapped.fastq.1.gz ${prefix}.unmapped_1.fastq.gz - fi - if [ -f ${prefix}.unmapped.fastq.2.gz ]; then - mv ${prefix}.unmapped.fastq.2.gz ${prefix}.unmapped_2.fastq.gz - fi + def samtools_command = sort_bam ? 'sort' : 'view' - cat <<-END_VERSIONS > versions.yml - "${task.process}": - bowtie2: \$(echo \$(bowtie2 --version 2>&1) | sed 's/^.*bowtie2-align-s version //; s/ .*\$//') - samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') - pigz: \$( pigz --version 2>&1 | sed 's/pigz //g' ) - END_VERSIONS - """ - } + """ + INDEX=`find -L ./ -name "*.rev.1.bt2" | sed "s/.rev.1.bt2//"` + [ -z "\$INDEX" ] && INDEX=`find -L ./ -name "*.rev.1.bt2l" | sed "s/.rev.1.bt2l//"` + [ -z "\$INDEX" ] && echo "Bowtie2 index files not found" 1>&2 && exit 1 + + bowtie2 \\ + -x \$INDEX \\ + $reads_args \\ + --threads $task.cpus \\ + $unaligned \\ + $args \\ + 2> ${prefix}.bowtie2.log \\ + | samtools $samtools_command $args2 --threads $task.cpus -o ${prefix}.bam - + + if [ -f ${prefix}.unmapped.fastq.1.gz ]; then + mv ${prefix}.unmapped.fastq.1.gz ${prefix}.unmapped_1.fastq.gz + fi + + if [ -f ${prefix}.unmapped.fastq.2.gz ]; then + mv ${prefix}.unmapped.fastq.2.gz ${prefix}.unmapped_2.fastq.gz + fi + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + bowtie2: \$(echo \$(bowtie2 --version 2>&1) | sed 's/^.*bowtie2-align-s version //; s/ .*\$//') + samtools: \$(echo \$(samtools --version 2>&1) | sed 's/^.*samtools //; s/Using.*\$//') + pigz: \$( pigz --version 2>&1 | sed 's/pigz //g' ) + END_VERSIONS + """ } diff --git a/modules/nf-core/modules/bowtie2/align/meta.yml b/modules/nf-core/modules/bowtie2/align/meta.yml index f80421eca..42ba0f964 100644 --- a/modules/nf-core/modules/bowtie2/align/meta.yml +++ b/modules/nf-core/modules/bowtie2/align/meta.yml @@ -2,7 +2,9 @@ name: bowtie2_align description: Align reads to a reference genome using bowtie2 keywords: - align + - map - fasta + - fastq - genome - reference tools: @@ -29,6 +31,15 @@ input: type: file description: Bowtie2 genome index files pattern: "*.ebwt" + - save_unaligned: + type: boolean + description: | + Save reads that do not map to the reference (true) or discard them (false) + (default: false) + - sort_bam: + type: boolean + description: use samtools sort (true) or samtools view (false) + pattern: "true or false" output: - bam: type: file diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf b/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf index 327d51005..203e485ae 100644 --- a/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/main.nf @@ -2,10 +2,10 @@ process CUSTOM_DUMPSOFTWAREVERSIONS { label 'process_low' // Requires `pyyaml` which does not have a dedicated container but is in the MultiQC container - conda (params.enable_conda ? "bioconda::multiqc=1.11" : null) + conda (params.enable_conda ? 'bioconda::multiqc=1.13a' : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/multiqc:1.11--pyhdfd78af_0' : - 'quay.io/biocontainers/multiqc:1.11--pyhdfd78af_0' }" + 'https://depot.galaxyproject.org/singularity/multiqc:1.13a--pyhdfd78af_1' : + 'quay.io/biocontainers/multiqc:1.13a--pyhdfd78af_1' }" input: path versions diff --git a/modules/nf-core/modules/gunzip/main.nf b/modules/nf-core/modules/gunzip/main.nf index 61bf1afa5..703670495 100644 --- a/modules/nf-core/modules/gunzip/main.nf +++ b/modules/nf-core/modules/gunzip/main.nf @@ -31,4 +31,14 @@ process GUNZIP { gunzip: \$(echo \$(gunzip --version 2>&1) | sed 's/^.*(gzip) //; s/ Copyright.*\$//') END_VERSIONS """ + + stub: + gunzip = archive.toString() - '.gz' + """ + touch $gunzip + cat <<-END_VERSIONS > versions.yml + "${task.process}": + gunzip: \$(echo \$(gunzip --version 2>&1) | sed 's/^.*(gzip) //; s/ Copyright.*\$//') + END_VERSIONS + """ } diff --git a/modules/nf-core/modules/homer/annotatepeaks/main.nf b/modules/nf-core/modules/homer/annotatepeaks/main.nf index c9da82ed4..9056a5ab5 100644 --- a/modules/nf-core/modules/homer/annotatepeaks/main.nf +++ b/modules/nf-core/modules/homer/annotatepeaks/main.nf @@ -1,9 +1,8 @@ -def VERSION = '4.11' // Version information not provided by tool on CLI - process HOMER_ANNOTATEPEAKS { tag "$meta.id" label 'process_medium' + // WARN: Version information not provided by tool on CLI. Please update version string below when bumping container versions. conda (params.enable_conda ? "bioconda::homer=4.11" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? 'https://depot.galaxyproject.org/singularity/homer:4.11--pl526hc9558a2_3' : @@ -24,6 +23,7 @@ process HOMER_ANNOTATEPEAKS { script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" + def VERSION = '4.11' // WARN: Version information not provided by tool on CLI. Please update this string when bumping container versions. """ annotatePeaks.pl \\ $peak \\ diff --git a/modules/nf-core/modules/multiqc/main.nf b/modules/nf-core/modules/multiqc/main.nf deleted file mode 100644 index ae019dbf0..000000000 --- a/modules/nf-core/modules/multiqc/main.nf +++ /dev/null @@ -1,43 +0,0 @@ -process MULTIQC { - label 'process_medium' - - conda (params.enable_conda ? 'bioconda::multiqc=1.12' : null) - container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/multiqc:1.12--pyhdfd78af_0' : - 'quay.io/biocontainers/multiqc:1.12--pyhdfd78af_0' }" - - input: - path multiqc_files - - output: - path "*multiqc_report.html", emit: report - path "*_data" , emit: data - path "*_plots" , optional:true, emit: plots - path "versions.yml" , emit: versions - - when: - task.ext.when == null || task.ext.when - - script: - def args = task.ext.args ?: '' - """ - multiqc -f $args . - - cat <<-END_VERSIONS > versions.yml - "${task.process}": - multiqc: \$( multiqc --version | sed -e "s/multiqc, version //g" ) - END_VERSIONS - """ - - stub: - """ - touch multiqc_data - touch multiqc_plots - touch multiqc_report.html - - cat <<-END_VERSIONS > versions.yml - "${task.process}": - multiqc: \$( multiqc --version | sed -e "s/multiqc, version //g" ) - END_VERSIONS - """ -} diff --git a/modules/nf-core/modules/multiqc/meta.yml b/modules/nf-core/modules/multiqc/meta.yml deleted file mode 100644 index 6fa891efc..000000000 --- a/modules/nf-core/modules/multiqc/meta.yml +++ /dev/null @@ -1,40 +0,0 @@ -name: MultiQC -description: Aggregate results from bioinformatics analyses across many samples into a single report -keywords: - - QC - - bioinformatics tools - - Beautiful stand-alone HTML report -tools: - - multiqc: - description: | - MultiQC searches a given directory for analysis logs and compiles a HTML report. - It's a general use tool, perfect for summarising the output from numerous bioinformatics tools. - homepage: https://multiqc.info/ - documentation: https://multiqc.info/docs/ - licence: ["GPL-3.0-or-later"] -input: - - multiqc_files: - type: file - description: | - List of reports / files recognised by MultiQC, for example the html and zip output of FastQC -output: - - report: - type: file - description: MultiQC report file - pattern: "multiqc_report.html" - - data: - type: dir - description: MultiQC data dir - pattern: "multiqc_data" - - plots: - type: file - description: Plots created by MultiQC - pattern: "*_data" - - versions: - type: file - description: File containing software versions - pattern: "versions.yml" -authors: - - "@abhi18av" - - "@bunop" - - "@drpatelh" diff --git a/modules/nf-core/modules/phantompeakqualtools/main.nf b/modules/nf-core/modules/phantompeakqualtools/main.nf index d8f733425..43fca6836 100644 --- a/modules/nf-core/modules/phantompeakqualtools/main.nf +++ b/modules/nf-core/modules/phantompeakqualtools/main.nf @@ -1,9 +1,8 @@ -def VERSION = '1.2.2' // Version information not provided by tool on CLI - process PHANTOMPEAKQUALTOOLS { tag "$meta.id" label 'process_medium' + // WARN: Version information not provided by tool on CLI. Please update version string below when bumping container versions. conda (params.enable_conda ? "bioconda::phantompeakqualtools=1.2.2" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? 'https://depot.galaxyproject.org/singularity/phantompeakqualtools:1.2.2--0' : @@ -25,6 +24,7 @@ process PHANTOMPEAKQUALTOOLS { def args = task.ext.args ?: '' def args2 = task.ext.args2 ?: '' def prefix = task.ext.prefix ?: "${meta.id}" + def VERSION = '1.2.2' // WARN: Version information not provided by tool on CLI. Please update this string when bumping container versions. """ RUN_SPP=`which run_spp.R` Rscript $args -e "library(caTools); source(\\"\$RUN_SPP\\")" -c="$bam" -savp="${prefix}.spp.pdf" -savd="${prefix}.spp.Rdata" -out="${prefix}.spp.out" $args2 diff --git a/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf b/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf index a653b5490..63f4e8729 100644 --- a/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf +++ b/modules/nf-core/modules/picard/collectmultiplemetrics/main.nf @@ -2,14 +2,15 @@ process PICARD_COLLECTMULTIPLEMETRICS { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? "bioconda::picard=2.27.1" : null) + conda (params.enable_conda ? "bioconda::picard=2.27.4" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/picard:2.27.1--hdfd78af_0' : - 'quay.io/biocontainers/picard:2.27.1--hdfd78af_0' }" + 'https://depot.galaxyproject.org/singularity/picard:2.27.4--hdfd78af_0' : + 'quay.io/biocontainers/picard:2.27.4--hdfd78af_0' }" input: tuple val(meta), path(bam) path fasta + path fai output: tuple val(meta), path("*_metrics"), emit: metrics @@ -22,6 +23,7 @@ process PICARD_COLLECTMULTIPLEMETRICS { script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" + def reference = fasta ? "--REFERENCE_SEQUENCE ${fasta}" : "" def avail_mem = 3 if (!task.memory) { log.info '[Picard CollectMultipleMetrics] Available memory not known - defaulting to 3GB. Specify process memory requirements to change this.' @@ -35,7 +37,7 @@ process PICARD_COLLECTMULTIPLEMETRICS { $args \\ --INPUT $bam \\ --OUTPUT ${prefix}.CollectMultipleMetrics \\ - --REFERENCE_SEQUENCE $fasta + $reference cat <<-END_VERSIONS > versions.yml "${task.process}": diff --git a/modules/nf-core/modules/picard/collectmultiplemetrics/meta.yml b/modules/nf-core/modules/picard/collectmultiplemetrics/meta.yml index 68b5c65ee..c11b02cfa 100644 --- a/modules/nf-core/modules/picard/collectmultiplemetrics/meta.yml +++ b/modules/nf-core/modules/picard/collectmultiplemetrics/meta.yml @@ -28,6 +28,10 @@ input: - fasta: type: file description: Genome fasta file + - fai: + type: file + description: Index of FASTA file. Only needed when fasta is supplied. + pattern: "*.fai" output: - meta: type: map diff --git a/modules/nf-core/modules/picard/markduplicates/main.nf b/modules/nf-core/modules/picard/markduplicates/main.nf index 1565c6478..4e559fea0 100644 --- a/modules/nf-core/modules/picard/markduplicates/main.nf +++ b/modules/nf-core/modules/picard/markduplicates/main.nf @@ -2,10 +2,10 @@ process PICARD_MARKDUPLICATES { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? "bioconda::picard=2.27.1" : null) + conda (params.enable_conda ? "bioconda::picard=2.27.4" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/picard:2.27.1--hdfd78af_0' : - 'quay.io/biocontainers/picard:2.27.1--hdfd78af_0' }" + 'https://depot.galaxyproject.org/singularity/picard:2.27.4--hdfd78af_0' : + 'quay.io/biocontainers/picard:2.27.4--hdfd78af_0' }" input: tuple val(meta), path(bam) diff --git a/modules/nf-core/modules/picard/mergesamfiles/main.nf b/modules/nf-core/modules/picard/mergesamfiles/main.nf index 1e32c63a6..cccf4d3d5 100644 --- a/modules/nf-core/modules/picard/mergesamfiles/main.nf +++ b/modules/nf-core/modules/picard/mergesamfiles/main.nf @@ -2,10 +2,10 @@ process PICARD_MERGESAMFILES { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? "bioconda::picard=2.27.1" : null) + conda (params.enable_conda ? "bioconda::picard=2.27.4" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/picard:2.27.1--hdfd78af_0' : - 'quay.io/biocontainers/picard:2.27.1--hdfd78af_0' }" + 'https://depot.galaxyproject.org/singularity/picard:2.27.4--hdfd78af_0' : + 'quay.io/biocontainers/picard:2.27.4--hdfd78af_0' }" input: tuple val(meta), path(bams) diff --git a/modules/nf-core/modules/samtools/flagstat/main.nf b/modules/nf-core/modules/samtools/flagstat/main.nf index b87b21081..03ec2dcf4 100644 --- a/modules/nf-core/modules/samtools/flagstat/main.nf +++ b/modules/nf-core/modules/samtools/flagstat/main.nf @@ -19,12 +19,13 @@ process SAMTOOLS_FLAGSTAT { script: def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" """ samtools \\ flagstat \\ --threads ${task.cpus-1} \\ $bam \\ - > ${bam}.flagstat + > ${prefix}.flagstat cat <<-END_VERSIONS > versions.yml "${task.process}": diff --git a/modules/nf-core/modules/samtools/idxstats/main.nf b/modules/nf-core/modules/samtools/idxstats/main.nf index a49ff35f9..4b2454198 100644 --- a/modules/nf-core/modules/samtools/idxstats/main.nf +++ b/modules/nf-core/modules/samtools/idxstats/main.nf @@ -19,11 +19,13 @@ process SAMTOOLS_IDXSTATS { script: def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" + """ samtools \\ idxstats \\ $bam \\ - > ${bam}.idxstats + > ${prefix}.idxstats cat <<-END_VERSIONS > versions.yml "${task.process}": diff --git a/modules/nf-core/modules/samtools/stats/main.nf b/modules/nf-core/modules/samtools/stats/main.nf index bbdc3240d..89b92d79e 100644 --- a/modules/nf-core/modules/samtools/stats/main.nf +++ b/modules/nf-core/modules/samtools/stats/main.nf @@ -20,6 +20,7 @@ process SAMTOOLS_STATS { script: def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "${meta.id}" def reference = fasta ? "--reference ${fasta}" : "" """ samtools \\ @@ -27,7 +28,7 @@ process SAMTOOLS_STATS { --threads ${task.cpus-1} \\ ${reference} \\ ${input} \\ - > ${input}.stats + > ${prefix}.stats cat <<-END_VERSIONS > versions.yml "${task.process}": @@ -38,7 +39,7 @@ process SAMTOOLS_STATS { stub: def prefix = task.ext.prefix ?: "${meta.id}" """ - touch ${input}.stats + touch ${prefix}.stats cat <<-END_VERSIONS > versions.yml "${task.process}": diff --git a/modules/nf-core/modules/ucsc/bedgraphtobigwig/main.nf b/modules/nf-core/modules/ucsc/bedgraphtobigwig/main.nf index ef0ca088f..b18b190ad 100644 --- a/modules/nf-core/modules/ucsc/bedgraphtobigwig/main.nf +++ b/modules/nf-core/modules/ucsc/bedgraphtobigwig/main.nf @@ -1,9 +1,8 @@ -def VERSION = '377' // Version information not provided by tool on CLI - process UCSC_BEDGRAPHTOBIGWIG { tag "$meta.id" label 'process_medium' + // WARN: Version information not provided by tool on CLI. Please update version string below when bumping container versions. conda (params.enable_conda ? "bioconda::ucsc-bedgraphtobigwig=377" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? 'https://depot.galaxyproject.org/singularity/ucsc-bedgraphtobigwig:377--h446ed27_1' : @@ -23,6 +22,7 @@ process UCSC_BEDGRAPHTOBIGWIG { script: def args = task.ext.args ?: '' def prefix = task.ext.prefix ?: "${meta.id}" + def VERSION = '377' // WARN: Version information not provided by tool on CLI. Please update this string when bumping container versions. """ bedGraphToBigWig \\ $bedgraph \\ diff --git a/modules/nf-core/modules/untar/main.nf b/modules/nf-core/modules/untar/main.nf index 058d17644..29ab10a50 100644 --- a/modules/nf-core/modules/untar/main.nf +++ b/modules/nf-core/modules/untar/main.nf @@ -21,12 +21,18 @@ process UNTAR { def args = task.ext.args ?: '' def args2 = task.ext.args2 ?: '' untar = archive.toString() - '.tar.gz' + """ + mkdir output + tar \\ + -C output --strip-components 1 \\ -xzvf \\ $args \\ $archive \\ - $args2 \\ + $args2 + + mv output ${untar} cat <<-END_VERSIONS > versions.yml "${task.process}": diff --git a/subworkflows/nf-core/align_bowtie2.nf b/subworkflows/nf-core/align_bowtie2.nf index bb0888f3c..352191313 100644 --- a/subworkflows/nf-core/align_bowtie2.nf +++ b/subworkflows/nf-core/align_bowtie2.nf @@ -18,7 +18,7 @@ workflow ALIGN_BOWTIE2 { // // Map reads with BWA // - BOWTIE2_ALIGN(reads, index, save_unaligned) + BOWTIE2_ALIGN(reads, index, save_unaligned, false) ch_versions = ch_versions.mix(BOWTIE2_ALIGN.out.versions.first()) // diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 7db9f9016..13f859882 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -290,7 +290,8 @@ workflow CHIPSEQ { if (!params.skip_picard_metrics) { PICARD_COLLECTMULTIPLEMETRICS ( FILTER_BAM_BAMTOOLS.out.bam, - PREPARE_GENOME.out.fasta + PREPARE_GENOME.out.fasta, + [] ) ch_picardcollectmultiplemetrics_multiqc = PICARD_COLLECTMULTIPLEMETRICS.out.metrics ch_versions = ch_versions.mix(PICARD_COLLECTMULTIPLEMETRICS.out.versions.first()) From a5aad852611f322dc1933e0f2a16feed285b44f3 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 21 Jul 2022 17:43:43 +0200 Subject: [PATCH 456/538] Fix error when skipping consensus peaks due to ext.when use --- workflows/chipseq.nf | 6 ++++-- 1 file changed, 4 insertions(+), 2 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 13f859882..8df584367 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -477,6 +477,7 @@ workflow CHIPSEQ { // // Consensus peaks analysis // + ch_macs2_consensus_bed_lib = Channel.empty() if (!params.skip_consensus_peaks) { // Create channel: [ meta , [ peaks ] ] // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] @@ -502,7 +503,8 @@ workflow CHIPSEQ { MACS2_CONSENSUS ( ch_antibody_peaks ) - ch_versions = ch_versions.mix(MACS2_CONSENSUS.out.versions) + ch_macs2_consensus_bed_lib = MACS2_CONSENSUS_LIB.out.bed + ch_versions = ch_versions.mix(MACS2_CONSENSUS.out.versions) if (!params.skip_peak_annotation) { HOMER_ANNOTATEPEAKS_CONSENSUS ( @@ -559,7 +561,7 @@ workflow CHIPSEQ { PREPARE_GENOME.out.fasta, UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), ch_macs2_peaks.collect{it[1]}.ifEmpty([]), - MACS2_CONSENSUS.out.bed.collect{it[1]}.ifEmpty([]), + ch_macs2_consensus_bed_lib.collect{it[1]}.ifEmpty([]), "bwa/mergedLibrary/bigwig", { ["bwa/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' From dc7b5863c51df98e24196aaf8e65c0e8ee90a9ba Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 21 Jul 2022 17:51:47 +0200 Subject: [PATCH 457/538] Be careful when copy/pasting --- workflows/chipseq.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 8df584367..87520cf57 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -503,7 +503,7 @@ workflow CHIPSEQ { MACS2_CONSENSUS ( ch_antibody_peaks ) - ch_macs2_consensus_bed_lib = MACS2_CONSENSUS_LIB.out.bed + ch_macs2_consensus_bed_lib = MACS2_CONSENSUS.out.bed ch_versions = ch_versions.mix(MACS2_CONSENSUS.out.versions) if (!params.skip_peak_annotation) { From fa733cca012ac938bb2da5d4441f52f1b786d13d Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 21 Jul 2022 22:36:39 +0200 Subject: [PATCH 458/538] Update changelog --- CHANGELOG.md | 2 ++ 1 file changed, 2 insertions(+) diff --git a/CHANGELOG.md b/CHANGELOG.md index 953213af5..a9b1b4616 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -21,6 +21,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 - [nf-core/tools#1415](https://github.com/nf-core/tools/issues/1415) - Make `--outdir` a mandatory parameter - [[282](https://github.com/nf-core/chipseq/issues/282)] - Fix `genome.fa` publication for IGV. - [[280](https://github.com/nf-core/chipseq/issues/280)] - Update `macs_gsize` in `igenomes.config`, create a new `--read_length` parameter and implement the logic to calculate `--macs_gsize` when the parameter is missing. +- Eliminate `if`s conditions from `deseq2_qc` and `macs2_consensus` {local module and use `ext.when` instead. +- Remove `deseq2` differential binding analysis of consensus peaks. ### Parameters From 8a5f546badd0e809806c903efc7af7dc4f78ce7f Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 25 Jul 2022 11:14:01 +0200 Subject: [PATCH 459/538] Fix path to igv files --- workflows/chipseq.nf | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 87520cf57..b18b425bc 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -562,11 +562,11 @@ workflow CHIPSEQ { UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), ch_macs2_peaks.collect{it[1]}.ifEmpty([]), ch_macs2_consensus_bed_lib.collect{it[1]}.ifEmpty([]), - "bwa/mergedLibrary/bigwig", - { ["bwa/mergedLibrary/macs2", + { "${params.aligner}/mergedLibrary/bigwig" }, + { ["${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, - { ["bwa/mergedLibrary/macs2", + { ["${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') } ) From ea4b0cf6b88c887b98557b8270c6d5146b29aa00 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 25 Jul 2022 13:21:37 +0200 Subject: [PATCH 460/538] Fix consensus peaks path for IGV --- workflows/chipseq.nf | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index b18b425bc..9da18df13 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -567,7 +567,9 @@ workflow CHIPSEQ { params.narrow_peak? '/narrowPeak' : '/broadPeak' ].join('') }, { ["${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/consensus', + "/${meta.id}" ].join('') } ) ch_versions = ch_versions.mix(IGV.out.versions) From 190939e985fe62ab9451aa72f75dc2afb6352eeb Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 27 Jul 2022 12:02:52 +0200 Subject: [PATCH 461/538] Fix consensus peaks path for IGV --- conf/modules.config | 10 +++------- workflows/chipseq.nf | 3 +-- 2 files changed, 4 insertions(+), 9 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 36dbe73ec..d16f49edf 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -616,8 +616,7 @@ if (!params.skip_consensus_peaks) { path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus', - "/${meta.id}" + '/consensus' ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } @@ -630,8 +629,7 @@ if (!params.skip_consensus_peaks) { path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus', - "/${meta.id}" + '/consensus' ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } @@ -648,8 +646,7 @@ if (!params.skip_consensus_peaks) { path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus', - "/${meta.id}" + '/consensus' ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } @@ -673,7 +670,6 @@ if (!params.skip_consensus_peaks) { "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus', - "/${meta.id}", '/deseq2' ].join('') }, mode: params.publish_dir_mode, diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 9da18df13..ad47283d4 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -568,8 +568,7 @@ workflow CHIPSEQ { ].join('') }, { ["${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus', - "/${meta.id}" + '/consensus' ].join('') } ) ch_versions = ch_versions.mix(IGV.out.versions) From f3f3a70581cd230f5dc87e20ab48daa9b4bc3828 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 27 Jul 2022 12:28:08 +0200 Subject: [PATCH 462/538] Switch --preset chip by its argument to not include the removal of duplicates --- conf/modules.config | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index d16f49edf..42806a6d7 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -253,7 +253,7 @@ if (params.aligner == 'chromap') { ] } withName: CHROMAP_CHROMAP { - ext.args = '--preset chip --SAM' + ext.args = '-l 2000 --low-mem --SAM' ext.prefix = { "${meta.id}.Lb" } publishDir = [ path: { "${params.outdir}/${params.aligner}/library" }, From 61ecb07ade32043ebd00018390898abc6cc67acf Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 27 Jul 2022 14:38:22 +0200 Subject: [PATCH 463/538] Add chromap back to ci tests --- .github/workflows/ci.yml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 4a040e5c3..d968b6343 100755 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -76,7 +76,7 @@ jobs: matrix: aligner: - "bowtie2" - # - "chromap" + - "chromap" - "star" steps: - name: Check out pipeline code From 4a191aba9cf8d012d927df552adadbaebb8bc9b8 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 29 Jul 2022 16:09:01 +0200 Subject: [PATCH 464/538] Suggested fix for macs --- conf/modules.config | 9 +++++---- 1 file changed, 5 insertions(+), 4 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 42806a6d7..ea54ccf19 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -520,10 +520,11 @@ process { withName: 'MACS2_CALLPEAK' { ext.args = [ '--keep-dup all', - params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}", - params.save_macs_pileup ? '--bdg --SPMR' : '', - params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '', - params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '' + params.narrow_peak ? '' : "--broad --broad-cutoff ${params.broad_cutoff}", + params.save_macs_pileup ? '--bdg --SPMR' : '', + params.macs_fdr ? "--qvalue ${params.macs_fdr}" : '', + params.macs_pvalue ? "--pvalue ${params.macs_pvalue}" : '', + params.aligner == "chromap" ? "--format BAM" : '' ].join(' ').trim() publishDir = [ path: { [ From f5e46f647d12361555f68ace9b098f4b99835637 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 2 Aug 2022 18:12:42 +0200 Subject: [PATCH 465/538] Filter paired end data when using chromap --- workflows/chipseq.nf | 30 +++++++++++++++++++++++++++++- 1 file changed, 29 insertions(+), 1 deletion(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index ad47283d4..f9dc2853c 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -206,7 +206,35 @@ workflow CHIPSEQ { PREPARE_GENOME.out.chromap_index, PREPARE_GENOME.out.fasta ) - ch_genome_bam = ALIGN_CHROMAP.out.bam + + // Filter out paired-end reads until the issue below is fixed + // https://github.com/nf-core/chipseq/issues/291 + // ch_genome_bam = ALIGN_CHROMAP.out.bam + ALIGN_CHROMAP + .out + .bam + .branch { + meta, bam -> + single_end: meta.single_end + return [ meta, bam ] + paired_end: !meta.single_end + return [ meta, bam ] + }.set { ch_genome_bam_chromap } + + ch_genome_bam_chromap.paired_end + .collect() + .map { it -> + def count = it.size() + if (count > 0) { + log.warn "=============================================================================\n" + + " Paired-end files produced by chromap can not be used by some downstream tools due the issue below:\n" + + " https://github.com/nf-core/chipseq/issues/291\n" + + " They will be excluded from the analysis. Consider to use a different aligner\n" + + "===================================================================================" + } + } + + ch_genome_bam = ch_genome_bam_chromap.single_end ch_genome_bam_index = ALIGN_CHROMAP.out.bai ch_samtools_stats = ALIGN_CHROMAP.out.stats ch_samtools_flagstat = ALIGN_CHROMAP.out.flagstat From f57d8da964aab4c24d8153dd63fec9a40975c878 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 3 Aug 2022 16:18:52 +0200 Subject: [PATCH 466/538] Fix indexes publication --- conf/modules.config | 8 +++++++- 1 file changed, 7 insertions(+), 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index ea54ccf19..f1383590b 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -54,9 +54,15 @@ process { withName: 'UNTAR_.*' { ext.args2 = '--no-same-owner' + publishDir = [ + path: { "${params.outdir}/genome/index" }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename }, + enabled: params.save_reference + ] } - withName: 'UNTAR_.*|BWA_INDEX|BOWTIE2_BUILD|STAR_GENOMEGENERATE' { + withName: 'BWA_INDEX|BOWTIE2_BUILD|STAR_GENOMEGENERATE' { publishDir = [ path: { "${params.outdir}/genome/index" }, mode: params.publish_dir_mode, From 17aac1dbad5d66a79a3c2cb5be4cfdeac6fc23eb Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 3 Aug 2022 17:24:55 +0200 Subject: [PATCH 467/538] Change deeptools by deepTools (results dir) --- conf/modules.config | 8 ++++---- 1 file changed, 4 insertions(+), 4 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index f1383590b..7eb7ede2c 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -472,7 +472,7 @@ if (!params.skip_plot_profile) { ext.args = 'scale-regions --regionBodyLength 1000 --beforeRegionStartLength 3000 --afterRegionStartLength 3000 --skipZeros --smartLabels' ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotProfile" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/deepTools/plotProfile" }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -481,7 +481,7 @@ if (!params.skip_plot_profile) { withName: 'DEEPTOOLS_PLOTPROFILE' { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotProfile" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/deepTools/plotProfile" }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -490,7 +490,7 @@ if (!params.skip_plot_profile) { withName: 'DEEPTOOLS_PLOTHEATMAP' { ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotProfile" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/deepTools/plotProfile" }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -514,7 +514,7 @@ if (!params.skip_plot_fingerprint) { ].join(' ').trim() } ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ - path: { "${params.outdir}/${params.aligner}/mergedLibrary/deeptools/plotFingerprint" }, + path: { "${params.outdir}/${params.aligner}/mergedLibrary/deepTools/plotFingerprint" }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] From a28cd2872bad8941461c73aebefa0d054939acb1 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 3 Aug 2022 23:43:54 +0200 Subject: [PATCH 468/538] Add annotate_boolean_peaks process --- conf/modules.config | 12 +++++++++++ modules/local/annotate_boolean_peaks.nf | 28 +++++++++++++++++++++++++ workflows/chipseq.nf | 10 +++++---- 3 files changed, 46 insertions(+), 4 deletions(-) create mode 100644 modules/local/annotate_boolean_peaks.nf diff --git a/conf/modules.config b/conf/modules.config index 7eb7ede2c..3de687a1f 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -581,6 +581,18 @@ if (!params.skip_peak_annotation) { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } + + withName: 'ANNOTATE_BOOLEAN_PEAKS' { + ext.prefix = { "${meta.id}_peaks" } + publishDir = [ + path: { [ + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } } if (!params.skip_peak_qc) { diff --git a/modules/local/annotate_boolean_peaks.nf b/modules/local/annotate_boolean_peaks.nf new file mode 100644 index 000000000..ba25e7ae9 --- /dev/null +++ b/modules/local/annotate_boolean_peaks.nf @@ -0,0 +1,28 @@ +process ANNOTATE_BOOLEAN_PEAKS { + + label 'process_low' + + conda (params.enable_conda ? "conda-forge::sed=4.7" : null) + container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? + 'https://depot.galaxyproject.org/singularity/ubuntu:20.04' : + 'ubuntu:20.04' }" + + input: + tuple val(meta), path(boolean_txt), path(homer_peaks) + + output: + path '*.csv' , emit: csv + path "versions.yml", emit: versions + + script: + def prefix = task.ext.prefix ?: "${meta.id}" + """ + cut -f2- ${homer_peaks} | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt + paste $boolean_txt tmp.txt > ${prefix}.boolean.annotatePeaks.txt + + cat <<-END_VERSIONS > versions.yml + "${task.process}": + sed: \$(echo \$(sed --version 2>&1) | sed 's/^.*GNU sed) //; s/ .*\$//') + END_VERSIONS + """ +} diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index f9dc2853c..658a8b944 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -68,6 +68,7 @@ include { FRIP_SCORE } from '../modules/local/frip_scor include { PLOT_MACS2_QC } from '../modules/local/plot_macs2_qc' include { PLOT_HOMER_ANNOTATEPEAKS } from '../modules/local/plot_homer_annotatepeaks' include { MACS2_CONSENSUS } from '../modules/local/macs2_consensus' +include { ANNOTATE_BOOLEAN_PEAKS } from '../modules/local/annotate_boolean_peaks' include { DESEQ2_QC } from '../modules/local/deseq2_qc' include { IGV } from '../modules/local/igv' include { MULTIQC } from '../modules/local/multiqc' @@ -541,8 +542,11 @@ workflow CHIPSEQ { PREPARE_GENOME.out.gtf ) ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_CONSENSUS.out.versions) - // cut -f2- ${prefix}.annotatePeaks.txt | awk 'NR==1; NR > 1 {print \$0 | "sort -T '.' -k1,1 -k2,2n"}' | cut -f6- > tmp.txt - // paste $bool tmp.txt > ${prefix}.boolean.annotatePeaks.txt + + ANNOTATE_BOOLEAN_PEAKS ( + MACS2_CONSENSUS.out.boolean_txt.join(HOMER_ANNOTATEPEAKS_CONSENSUS.out.txt, by: [0]), + ) + ch_versions = ch_versions.mix(ANNOTATE_BOOLEAN_PEAKS.out.versions) } // Create channel: [ val(meta), ip_bam ] @@ -602,8 +606,6 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(IGV.out.versions) } - - // // MODULE: Pipeline reporting // From 53f2673b7d9de2dac7b86d9412f90b4f4b67e0e1 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 4 Aug 2022 10:21:27 +0200 Subject: [PATCH 469/538] Emit output of annotate_boolean_peaks --- modules/local/annotate_boolean_peaks.nf | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/modules/local/annotate_boolean_peaks.nf b/modules/local/annotate_boolean_peaks.nf index ba25e7ae9..8d45fe92f 100644 --- a/modules/local/annotate_boolean_peaks.nf +++ b/modules/local/annotate_boolean_peaks.nf @@ -11,8 +11,8 @@ process ANNOTATE_BOOLEAN_PEAKS { tuple val(meta), path(boolean_txt), path(homer_peaks) output: - path '*.csv' , emit: csv - path "versions.yml", emit: versions + path '*.boolean.annotatePeaks.txt', emit: annotate_peaks_txt + path "versions.yml" , emit: versions script: def prefix = task.ext.prefix ?: "${meta.id}" From 0bcdb8482c0358544b730e7041910a0a6cadf31e Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 4 Aug 2022 11:26:04 +0200 Subject: [PATCH 470/538] Fix publish folder for annotate_boolean_peaks --- conf/modules.config | 6 ++++-- 1 file changed, 4 insertions(+), 2 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 3de687a1f..8e0b8245e 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -587,11 +587,13 @@ if (!params.skip_peak_annotation) { publishDir = [ path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/consensus' + ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] + } } From b627caa96d6522dc5045f78bff5feb6159afd623 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 4 Aug 2022 15:25:44 +0200 Subject: [PATCH 471/538] Emit rds file form deseq2 --- modules/local/deseq2_qc.nf | 1 + 1 file changed, 1 insertion(+) diff --git a/modules/local/deseq2_qc.nf b/modules/local/deseq2_qc.nf index acc4d595d..bdf5535af 100644 --- a/modules/local/deseq2_qc.nf +++ b/modules/local/deseq2_qc.nf @@ -15,6 +15,7 @@ process DESEQ2_QC { output: path "*.pdf" , optional:true, emit: pdf path "*.RData" , optional:true, emit: rdata + path "*.rds" , optional:true, emit: rds path "*pca.vals.txt" , optional:true, emit: pca_txt path "*pca.vals_mqc.tsv" , optional:true, emit: pca_multiqc path "*sample.dists.txt" , optional:true, emit: dists_txt From 2aff26ab6492f1bb321a830639201a40abdf2e9b Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 4 Aug 2022 15:53:07 +0200 Subject: [PATCH 472/538] Update docs --- docs/output.md | 38 +++++++++++++++++++++++++------------- docs/usage.md | 8 ++++---- 2 files changed, 29 insertions(+), 17 deletions(-) diff --git a/docs/output.md b/docs/output.md index 8074696c6..6fde66dec 100644 --- a/docs/output.md +++ b/docs/output.md @@ -2,7 +2,13 @@ ## Introduction -This document describes the output produced by the pipeline. Most of the plots are taken from the MultiQC report, which summarises results at the end of the pipeline. +This document describes the output produced by the pipeline. Most of the plots are taken from the MultiQC report generated from the [full-sized test dataset](https://github.com/nf-core/test-datasets/tree/chipseq#full-test-dataset-origin) for the pipeline using a command similar to the one below: + +```console +nextflow run nf-core/chipseq -profile test_full, +``` + +The directories listed below will be created in the output directory after the pipeline has finished. All paths are relative to the top-level results directory. ## Pipeline overview @@ -10,8 +16,6 @@ The pipeline is built using [Nextflow](https://www.nextflow.io/). See [`main REA See [Illumina website](https://emea.illumina.com/techniques/sequencing/dna-sequencing/chip-seq.html) for more information regarding the ChIP-seq protocol, and for an extensive list of publications. -The directories listed below will be created in the output directory after the pipeline has finished. All paths are relative to the top-level results directory. - ## Library-level analysis The initial QC and alignments are performed at the library-level e.g. if the same library has been sequenced more than once to increase sequencing depth. This has the advantage of being able to assess each library individually, and the ability to process multiple libraries from the same sample in parallel. @@ -70,6 +74,8 @@ Adapter-trimmed reads are mapped to the reference assembly using the aligner set ![MultiQC - SAMtools stats plot](images/mqc_samtools_stats_plot.png) +> **NB:** Currently, paired-end files produced by `Chromap` are excluded from downstream analysis due to [this](https://github.com/nf-core/chipseq/issues/291) issue. Single-end files are processed normally. + #### Unmapped reads The `--save_unaligned` parameter enables to obtain FastQ files containing unmapped reads (only available for STAR and Bowtie2). @@ -116,7 +122,7 @@ The library-level alignments associated with the same sample are merged and subs
-[Picard MergeSamFiles and MarkDuplicates](https://broadinstitute.github.io/picard/command-line-overview.html) are used in combination to merge the alignments, and for the marking of duplicates, respectively. If you only have one library for any given replicate then the merging step isnt carried out because the library-level and merged library-level BAM files will be exactly the same. +[Picard MergeSamFiles and MarkDuplicates](https://broadinstitute.github.io/picard/command-line-overview.html) are used in combination to merge the alignments, and for the marking of duplicates, respectively. If you only have one library for any given replicate then the merging step is not carried out because the library-level and merged library-level BAM files will be exactly the same. ![MultiQC - Picard deduplication stats plot](images/mqc_picard_deduplication_plot.png) @@ -184,15 +190,15 @@ The results from deepTools plotProfile gives you a quick visualisation for the g - `*.xls`, `*.broadPeak` or `*.narrowPeak`, `*.gappedPeak`, `*summits.bed`: MACS2 output files - the files generated will depend on whether MACS2 has been run in _narrowPeak_ or _broadPeak_ mode. - `*.annotatePeaks.txt`: HOMER peak-to-gene annotation file. - `/mergedLibrary/macs2//qc/` - - `macs_peak.plots.pdf`: QC plots for MACS2 peaks. - - `macs_annotatePeaks.plots.pdf`: QC plots for peak-to-gene feature annotation. - - `*.FRiP_mqc.tsv`, `*.count_mqc.tsv`, `macs_annotatePeaks.summary_mqc.tsv`: MultiQC custom-content files for FRiP score, peak count and peak-to-gene ratios. + - `macs2_peak.plots.pdf`: QC plots for MACS2 peaks. + - `macs2_annotatePeaks.plots.pdf`: QC plots for peak-to-gene feature annotation. + - `*.FRiP_mqc.tsv`, `*.peak_count_mqc.tsv`, `annotatepeaks.summary_mqc.tsv`: MultiQC custom-content files for FRiP score, peak count and peak-to-gene ratios. > **NB:** `` in the directory structure above corresponds to the type of peak that you have specified to call with MACS2 i.e. `broadPeak` or `narrowPeak`. If you so wish, you can call both narrow and broad peaks without redoing the preceding steps in the pipeline such as the alignment and filtering. For example, if you already have broad peaks then just add `--narrow_peak -resume` to the command you used to run the pipeline, and these will be called too! However, resuming the pipeline will only be possible if you have not deleted the `work/` directory generated by the pipeline.
-[MACS2](https://github.com/taoliu/MACS) is one of the most popular peak-calling algorithms for ChIP-seq data. By default, the peaks are called with the MACS2 `--broad` parameter. If, however, you would like to call narrow peaks then please provide the `--narrow_peak` parameter when running the pipeline. See [MACS2 outputs](https://github.com/taoliu/MACS#output-files) for a description of the output files generated by MACS2. +[MACS2](https://github.com/macs3-project/MACS) is one of the most popular peak-calling algorithms for ChIP-seq data. By default, the peaks are called with the MACS2 `--broad` parameter. If, however, you would like to call narrow peaks then please provide the `--narrow_peak` parameter when running the pipeline. See [MACS2 outputs](https://github.com/macs3-project/MACS/blob/master/docs/callpeak.md#output-files) for a description of the output files generated by MACS2. ![MultiQC - MACS2 total peak count plot](images/mqc_macs2_peak_count_plot.png) @@ -209,7 +215,7 @@ Various QC plots per sample including number of peaks, fold-change distribution,
Output files -- `/mergedLibrary/macs2//consensus/` +- `/mergedLibrary/macs2//consensus` - `*.bed`: Consensus peak-set across all samples in BED format. - `*.saf`: Consensus peak-set across all samples in SAF format. Required by featureCounts for read quantification. - `*.featureCounts.txt`: Read counts across all samples relative to consensus peak-set. @@ -237,19 +243,25 @@ The [featureCounts](http://bioinf.wehi.edu.au/featureCounts/) tool is used to co
Output files -- `/mergedLibrary/macs2//consensus//deseq2/` +- `/mergedLibrary/macs2//consensus/deseq2/` - `*.sample.dists.txt`: Spreadsheet containing sample-to-sample distance across each consensus peak. - `*.plots.pdf`: File containing PCA and hierarchical clustering plots. - - `*.dds.rld.RData`: File containing R `dds` and `rld` objects generated by DESeq2. + - `*.dds.RData`: File containing R `DESeqDataSet` object generated by DESeq2, with either + an rlog or vst `assay` storing the variance-stabilised data. + - `*.rds`: Alternative version of the RData file suitable for + `readRDS` to give user control of the eventual object name. + - `*pca.vals.txt`: Matrix of values for the first 2 principal components. - `R_sessionInfo.log`: File containing information about R, the OS and attached or loaded packages. - - `/mergedLibrary/macs2//consensus//sizeFactors/` + - `/mergedLibrary/macs2//consensus/deseq2/sizeFactors/` - `*.txt`, `*.RData`: Files containing DESeq2 sizeFactors per sample.
[DESeq2](https://bioconductor.org/packages/release/bioc/vignettes/DESeq2/inst/doc/DESeq2.html) is more commonly used to perform differential expression analysis for RNA-seq datasets. However, it can also be used for ChIP-seq differential binding analysis, in which case you can imagine that instead of counts per gene for RNA-seq data we now have counts per bound region. -This pipeline uses a standardised DESeq2 analysis script to get an idea of the reproducibility within the experiment, and to assess the overall differential binding. Please note that this will not suit every experimental design, and if there are other problems with the experiment then it may not work as well as expected. For larger experiments, it may be recommended to use the `vst` transformation instead of the default `rlog` option. You can do this by providing the `--deseq2_vst` parameter to the pipeline. See [DESeq2 docs](http://bioconductor.org/packages/devel/bioc/vignettes/DESeq2/inst/doc/DESeq2.html#data-transformations-and-visualization) for a more detailed explanation. +**This pipeline uses a standardised DESeq2 analysis script to get an idea of the reproducibility within the experiment, and to assess the overall differential binding. Please note that this will not suit every experimental design, and if there are other problems with the experiment then it may not work as well as expected.** + +For larger experiments, it may be recommended to use the `vst` transformation instead of the default `rlog` option. You can do this by providing the `--deseq2_vst` parameter to the pipeline. See [DESeq2 docs](http://bioconductor.org/packages/devel/bioc/vignettes/DESeq2/inst/doc/DESeq2.html#data-transformations-and-visualization) for a more detailed explanation. ![MultiQC - DESeq2 PCA plot](images/mqc_deseq2_pca_plot.png) diff --git a/docs/usage.md b/docs/usage.md index 971a3c897..73ee535f4 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -16,7 +16,7 @@ You will need to create a samplesheet with information about the samples you wou The `sample` identifiers have to be the same when you have re-sequenced the same sample more than once e.g. to increase sequencing depth. The pipeline will perform the alignments in parallel, and subsequently merge them before further analysis. Below is an example where the samples called `WT_BCATENIN_IP_REP2` and `WT_INPUT_REP2` have been re-sequenced multiple times: -```bash +```console sample,fastq_1,fastq_2,antibody,control WT_BCATENIN_IP_REP1,BLA203A1_S27_L006_R1_001.fastq.gz,,BCATENIN,WT_INPUT WT_BCATENIN_IP_REP2,BLA203A25_S16_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT @@ -33,13 +33,13 @@ WT_INPUT_REP3,BLA203A31_S21_L003_R1_001.fastq.gz,,, The pipeline will auto-detect whether a sample is single- or paired-end using the information provided in the samplesheet. The samplesheet can have as many columns as you desire, however, there is a strict requirement for the first 5 columns to match those defined in the table below. -The `antibody` column is required to separate the downstream consensus peak merging and differential analysis for different antibodies. Its not advisable to generate a consensus peak set across different antibodies especially if their binding patterns are inherently different e.g. narrow transcription factors and broad histone marks. +The `antibody` column is required to separate the downstream consensus peak merging for different antibodies. Its not advisable to generate a consensus peak set across different antibodies especially if their binding patterns are inherently different e.g. narrow transcription factors and broad histone marks. The `control` column should be the `sample` identifier for the controls for any given IP. A final design file may look something like the one below. This is for two antibodies and associated controls, where the `WT_BCATENIN_IP_REP2` and `NAIVE_BCATENIN_IP_REP2` samples have been sequenced twice: -```bash +```console sample,fastq_1,fastq_2,antibody,control WT_BCATENIN_IP_REP1,BLA203A1_S27_L006_R1_001.fastq.gz,,BCATENIN,WT_INPUT WT_BCATENIN_IP_REP2,BLA203A25_S16_L001_R1_001.fastq.gz,,BCATENIN,WT_INPUT @@ -143,7 +143,7 @@ nextflow pull nf-core/chipseq It is a good idea to specify a pipeline version when running the pipeline on your data. This ensures that a specific version of the pipeline code and software are used when you run your pipeline. If you keep using the same tag, you'll be running the same version of the pipeline, even if there have been changes to the code since. -First, go to the [nf-core/chipseq releases page](https://github.com/nf-core/chipseq/releases) and find the latest version number - numeric only (eg. `1.3.1`). Then specify this when running the pipeline with `-r` (one hyphen) - eg. `-r 1.3.1`. +First, go to the [nf-core/chipseq releases page](https://github.com/nf-core/chipseq/releases) and find the latest version number - numeric only (eg. `1.2.2`). Then specify this when running the pipeline with `-r` (one hyphen) - eg. `-r 1.2.2`. This version number will be logged in reports when you run the pipeline, so that you'll know what you used when you look back in the future. From f845951c66bc28f8174921b691d8e42e391b608a Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 4 Aug 2022 15:53:19 +0200 Subject: [PATCH 473/538] Update changelog --- CHANGELOG.md | 5 +++-- 1 file changed, 3 insertions(+), 2 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index a9b1b4616..3184c3755 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -21,9 +21,10 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 - [nf-core/tools#1415](https://github.com/nf-core/tools/issues/1415) - Make `--outdir` a mandatory parameter - [[282](https://github.com/nf-core/chipseq/issues/282)] - Fix `genome.fa` publication for IGV. - [[280](https://github.com/nf-core/chipseq/issues/280)] - Update `macs_gsize` in `igenomes.config`, create a new `--read_length` parameter and implement the logic to calculate `--macs_gsize` when the parameter is missing. -- Eliminate `if`s conditions from `deseq2_qc` and `macs2_consensus` {local module and use `ext.when` instead. +- Eliminate `if`s conditions from `deseq2_qc` and `macs2_consensus` (local module and use `ext.when` instead). - Remove `deseq2` differential binding analysis of consensus peaks. - +- Filter paired-end files produced by `chromap` due to [this](https://github.com/nf-core/chipseq/issues/291) issue. +- Remove from the macs2 consensus publish directory since it can not be referred as input from the IGV process (meta.id not resolved at execution time). ### Parameters | Old parameter | New parameter | From e309bc1170ad6a92ca2a4c73ecd673db95e2a773 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 4 Aug 2022 15:54:06 +0200 Subject: [PATCH 474/538] Fix indents --- conf/modules.config | 24 ++++++++++++------------ 1 file changed, 12 insertions(+), 12 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 8e0b8245e..9f65d6af7 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -536,7 +536,7 @@ process { path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -549,7 +549,7 @@ process { "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/qc' - ].join('') }, + ].join('') }, enabled: false ] } @@ -576,7 +576,7 @@ if (!params.skip_peak_annotation) { path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -619,7 +619,7 @@ if (!params.skip_peak_annotation) { "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/qc' - ].join('') }, + ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -638,7 +638,7 @@ if (!params.skip_consensus_peaks) { "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus' - ].join('') }, + ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -651,7 +651,7 @@ if (!params.skip_consensus_peaks) { "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus' - ].join('') }, + ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -668,7 +668,7 @@ if (!params.skip_consensus_peaks) { "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus' - ].join('') }, + ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -692,7 +692,7 @@ if (!params.skip_consensus_peaks) { params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus', '/deseq2' - ].join('') }, + ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -708,7 +708,7 @@ if (!params.skip_igv) { path: { [ "${params.outdir}/igv", params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] @@ -722,9 +722,9 @@ if (!params.skip_multiqc) { ext.args = params.multiqc_title ? "--title \"$params.multiqc_title\"" : '' publishDir = [ path: { [ - "${params.outdir}/multiqc", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, + "${params.outdir}/multiqc", + params.narrow_peak? '/narrowPeak' : '/broadPeak' + ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] From c31fb69d014456e6be50f30d2ad6817d24fb0c01 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 4 Aug 2022 16:06:32 +0200 Subject: [PATCH 475/538] Make prettier happy --- CHANGELOG.md | 1 + 1 file changed, 1 insertion(+) diff --git a/CHANGELOG.md b/CHANGELOG.md index 3184c3755..bbec57434 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -25,6 +25,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 - Remove `deseq2` differential binding analysis of consensus peaks. - Filter paired-end files produced by `chromap` due to [this](https://github.com/nf-core/chipseq/issues/291) issue. - Remove from the macs2 consensus publish directory since it can not be referred as input from the IGV process (meta.id not resolved at execution time). + ### Parameters | Old parameter | New parameter | From 9c5c5ff0335abe4cd63440277fa254a621ce474d Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 4 Aug 2022 16:54:55 +0200 Subject: [PATCH 476/538] Update changelog --- CHANGELOG.md | 12 +++++++----- 1 file changed, 7 insertions(+), 5 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index bbec57434..b50bf7be5 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -3,10 +3,12 @@ The format is based on [Keep a Changelog](https://keepachangelog.com/en/1.0.0/) and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.html). -## [Unpublished Version / DEV] +## [1.2.2] - 2022-08-22 ### Enhancements & fixes +- Pipeline has been re-implemented in [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) +- All software containers are now exclusively obtained from [Biocontainers](https://biocontainers.pro/#/registry) - Updated pipeline template to [nf-core/tools 2.4.1](https://github.com/nf-core/tools/releases/tag/2.4.1) - [[#128](https://github.com/nf-core/chipseq/issues/128)] - Filter files with no peaks to avoid errors in downstream processes - [[#220](https://github.com/nf-core/chipseq/issues/220)] - Fix `phantompeakqualtools` protection stack overflow error @@ -20,11 +22,11 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 - [[228](https://github.com/nf-core/chipseq/issues/228)] - Update blacklist bed files. - [nf-core/tools#1415](https://github.com/nf-core/tools/issues/1415) - Make `--outdir` a mandatory parameter - [[282](https://github.com/nf-core/chipseq/issues/282)] - Fix `genome.fa` publication for IGV. -- [[280](https://github.com/nf-core/chipseq/issues/280)] - Update `macs_gsize` in `igenomes.config`, create a new `--read_length` parameter and implement the logic to calculate `--macs_gsize` when the parameter is missing. -- Eliminate `if`s conditions from `deseq2_qc` and `macs2_consensus` (local module and use `ext.when` instead). +- [[280](https://github.com/nf-core/chipseq/issues/280)] - Update `macs_gsize` in `igenomes.config`, create a new `--read_length` parameter and implement the logic to calculate `--macs_gsize` when the parameter is missing +- Eliminate `if`s conditions from `deseq2_qc` and `macs2_consensus` (local module and use `ext.when` instead) - Remove `deseq2` differential binding analysis of consensus peaks. -- Filter paired-end files produced by `chromap` due to [this](https://github.com/nf-core/chipseq/issues/291) issue. -- Remove from the macs2 consensus publish directory since it can not be referred as input from the IGV process (meta.id not resolved at execution time). +- Filter paired-end files produced by `chromap` due to [this](https://github.com/nf-core/chipseq/issues/291) issue +- Remove from the macs2 consensus publish directory since it can not be referred as input from the IGV process (meta.id not resolved at execution time) ### Parameters From fd59088a9640c7b25182fa7357c5e6b442152b7c Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 4 Aug 2022 17:45:24 +0200 Subject: [PATCH 477/538] Update readme and usage --- README.md | 18 ++++++++++-------- docs/usage.md | 10 +++++----- 2 files changed, 15 insertions(+), 13 deletions(-) diff --git a/README.md b/README.md index 91c27e231..c2fa0a60a 100644 --- a/README.md +++ b/README.md @@ -27,14 +27,18 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool 1. Raw read QC ([`FastQC`](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/)) 2. Adapter trimming ([`Trim Galore!`](https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/)) -3. Alignment ([`BWA`](https://sourceforge.net/projects/bio-bwa/files/)) +3. Choice of multiple aligners + 1.([`BWA`](https://sourceforge.net/projects/bio-bwa/files/)) + 2.([`Chromap`](https://github.com/haowenz/chromap)). **For paired-end reads only working until mapping steps, see [here](https://github.com/nf-core/chipseq/issues/291)** + 3.([`Bowtie2`](http://bowtie-bio.sourceforge.net/bowtie2/index.shtml)) + 4.([`STAR`](https://github.com/alexdobin/STAR)) 4. Mark duplicates ([`picard`](https://broadinstitute.github.io/picard/)) 5. Merge alignments from multiple libraries of the same sample ([`picard`](https://broadinstitute.github.io/picard/)) 1. Re-mark duplicates ([`picard`](https://broadinstitute.github.io/picard/)) 2. Filtering to remove: - reads mapping to blacklisted regions ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/), [`BEDTools`](https://github.com/arq5x/bedtools2/)) - reads that are marked as duplicates ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) - - reads that arent marked as primary alignments ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) + - reads that are not marked as primary alignments ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) - reads that are unmapped ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) - reads that map to multiple locations ([`SAMtools`](https://sourceforge.net/projects/samtools/files/samtools/)) - reads containing > 4 mismatches ([`BAMTools`](https://github.com/pezmaster31/bamtools)) @@ -47,11 +51,11 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool 5. Generate gene-body meta-profile from bigWig files ([`deepTools`](https://deeptools.readthedocs.io/en/develop/content/tools/plotProfile.html)) 6. Calculate genome-wide IP enrichment relative to control ([`deepTools`](https://deeptools.readthedocs.io/en/develop/content/tools/plotFingerprint.html)) 7. Calculate strand cross-correlation peak and ChIP-seq quality measures including NSC and RSC ([`phantompeakqualtools`](https://github.com/kundajelab/phantompeakqualtools)) - 8. Call broad/narrow peaks ([`MACS2`](https://github.com/taoliu/MACS)) + 8. Call broad/narrow peaks ([`MACS2`](https://github.com/macs3-project/MACS)) 9. Annotate peaks relative to gene features ([`HOMER`](http://homer.ucsd.edu/homer/download.html)) 10. Create consensus peakset across all samples and create tabular file to aid in the filtering of the data ([`BEDTools`](https://github.com/arq5x/bedtools2/)) 11. Count reads in consensus peaks ([`featureCounts`](http://bioinf.wehi.edu.au/featureCounts/)) - 12. Differential binding analysis, PCA and clustering ([`R`](https://www.r-project.org/), [`DESeq2`](https://bioconductor.org/packages/release/bioc/html/DESeq2.html)) + 12. PCA and clustering ([`R`](https://www.r-project.org/), [`DESeq2`](https://bioconductor.org/packages/release/bioc/html/DESeq2.html)) 6. Create IGV session file containing bigWig tracks, peaks and differential sites for data visualisation ([`IGV`](https://software.broadinstitute.org/software/igv/)). 7. Present QC for raw read, alignment, peak-calling and differential binding results ([`MultiQC`](http://multiqc.info/), [`R`](https://www.r-project.org/)) @@ -63,7 +67,7 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool 3. Download the pipeline and test it on a minimal dataset with a single command: - ```console + ```bash nextflow run nf-core/chipseq -profile test,YOURPROFILE --outdir ``` @@ -76,9 +80,7 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool 4. Start running your own analysis! - - - ```console + ```bash nextflow run nf-core/chipseq --input samplesheet.csv --outdir --genome GRCh37 -profile ``` diff --git a/docs/usage.md b/docs/usage.md index 73ee535f4..a0644ffef 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -8,7 +8,7 @@ You will need to create a samplesheet with information about the samples you would like to analyse before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 5 columns, and a header row as shown in the examples below. -```console +```bash --input '[path to samplesheet file]' ``` @@ -116,7 +116,7 @@ wget -L https://www.encodeproject.org/files/ENCFF356LFX/@@download/ENCFF356LFX.b The typical command for running the pipeline is as follows: -```console +```bash nextflow run nf-core/chipseq --input samplesheet.csv --outdir --genome GRCh37 -profile docker ``` @@ -124,7 +124,7 @@ This will launch the pipeline with the `docker` configuration profile. See below Note that the pipeline will create the following files in your working directory: -```console +```bash work # Directory containing the nextflow working files # Finished results in specified location (defined with --outdir) .nextflow_log # Log file from Nextflow @@ -135,7 +135,7 @@ work # Directory containing the nextflow working files When you run the above command, Nextflow automatically pulls the pipeline code from GitHub and stores it as a cached version. When running the pipeline after this, it will always use the cached version if available - even if the pipeline has been updated since. To make sure that you're running the latest version of the pipeline, make sure that you regularly update the cached version of the pipeline: -```console +```bash nextflow pull nf-core/chipseq ``` @@ -310,6 +310,6 @@ Some HPC setups also allow you to run nextflow within a cluster job submitted yo In some cases, the Nextflow Java virtual machines can start to request a large amount of memory. We recommend adding the following line to your environment to limit this (typically in `~/.bashrc` or `~./bash_profile`): -```console +```bash NXF_OPTS='-Xms1g -Xmx4g' ``` From 1b9192997a55f297ea8250b80b9d2a318d5b39d6 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 5 Aug 2022 14:58:50 +0200 Subject: [PATCH 478/538] Add bytesize talk to readme --- CHANGELOG.md | 2 +- README.md | 6 ++++++ 2 files changed, 7 insertions(+), 1 deletion(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index b50bf7be5..83d5a2734 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -27,7 +27,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 - Remove `deseq2` differential binding analysis of consensus peaks. - Filter paired-end files produced by `chromap` due to [this](https://github.com/nf-core/chipseq/issues/291) issue - Remove from the macs2 consensus publish directory since it can not be referred as input from the IGV process (meta.id not resolved at execution time) - +- Add bytesize link to readme. ### Parameters | Old parameter | New parameter | diff --git a/README.md b/README.md index c2fa0a60a..7078c2835 100644 --- a/README.md +++ b/README.md @@ -23,6 +23,12 @@ On release, automated continuous integration tests run the pipeline on a [full-s The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool to run tasks across multiple compute infrastructures in a very portable manner. It uses Docker/Singularity containers making installation trivial and results highly reproducible. The [Nextflow DSL2](https://www.nextflow.io/docs/latest/dsl2.html) implementation of this pipeline uses one container per process which makes it much easier to maintain and update software dependencies. Where possible, these processes have been submitted to and installed from [nf-core/modules](https://github.com/nf-core/modules) in order to make them available to all nf-core pipelines, and to everyone within the Nextflow community! +## Online videos + +A short talk about the history, current status and functionality on offer in this pipeline was given by Jose Espinosa-Carrasco ([@joseespinosa](https://github.com/joseespinosa)) on [26th July 2022](https://nf-co.re/events/2022/bytesize-chipseq) as part of the nf-core/bytesize series. + +You can find numerous talks on the [nf-core events page](https://nf-co.re/events) from various topics including writing pipelines/modules in Nextflow DSL2, using nf-core tooling, running nf-core pipelines as well as more generic content like contributing to Github. Please check them out! + ## Pipeline summary 1. Raw read QC ([`FastQC`](https://www.bioinformatics.babraham.ac.uk/projects/fastqc/)) From b87af07ded8b119a4d3c65085bb5d9abc570371f Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 5 Aug 2022 15:06:28 +0200 Subject: [PATCH 479/538] Make prettier happy --- CHANGELOG.md | 1 + 1 file changed, 1 insertion(+) diff --git a/CHANGELOG.md b/CHANGELOG.md index 83d5a2734..deeef1fe4 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -28,6 +28,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 - Filter paired-end files produced by `chromap` due to [this](https://github.com/nf-core/chipseq/issues/291) issue - Remove from the macs2 consensus publish directory since it can not be referred as input from the IGV process (meta.id not resolved at execution time) - Add bytesize link to readme. + ### Parameters | Old parameter | New parameter | From 18b8df8e6b3596e82c759312edd2903fbf00e0d9 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 10 Aug 2022 08:27:52 +0200 Subject: [PATCH 480/538] Bump pipeline version to 2.0.0 --- CHANGELOG.md | 4 ++-- nextflow.config | 2 +- 2 files changed, 3 insertions(+), 3 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index deeef1fe4..9421f2301 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -3,7 +3,7 @@ The format is based on [Keep a Changelog](https://keepachangelog.com/en/1.0.0/) and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.html). -## [1.2.2] - 2022-08-22 +## [2.0.0] - 2022-08-11 ### Enhancements & fixes @@ -25,7 +25,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 - [[280](https://github.com/nf-core/chipseq/issues/280)] - Update `macs_gsize` in `igenomes.config`, create a new `--read_length` parameter and implement the logic to calculate `--macs_gsize` when the parameter is missing - Eliminate `if`s conditions from `deseq2_qc` and `macs2_consensus` (local module and use `ext.when` instead) - Remove `deseq2` differential binding analysis of consensus peaks. -- Filter paired-end files produced by `chromap` due to [this](https://github.com/nf-core/chipseq/issues/291) issue +- [[280](https://github.com/nf-core/chipseq/issues/291) - Filter paired-end files produced by `chromap` since the resulting `BAM` files can not be processed downstream. - Remove from the macs2 consensus publish directory since it can not be referred as input from the IGV process (meta.id not resolved at execution time) - Add bytesize link to readme. diff --git a/nextflow.config b/nextflow.config index 6e0603d5b..168e90eab 100644 --- a/nextflow.config +++ b/nextflow.config @@ -218,7 +218,7 @@ manifest { description = 'ChIP-seq peak-calling and differential analysis pipeline.' mainScript = 'main.nf' nextflowVersion = '!>=21.10.3' - version = '1.3.0dev' + version = '2.0.0' } // Load modules.config for DSL2 module specific options From f1894d1e6aa18ea72a42dcb53c42b8ea985926ac Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 10 Aug 2022 11:54:53 +0200 Subject: [PATCH 481/538] Bump multiqc version to 1.13a --- CHANGELOG.md | 2 +- modules/local/multiqc.nf | 6 +++--- 2 files changed, 4 insertions(+), 4 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 9421f2301..228444dfa 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -61,7 +61,7 @@ Note, since the pipeline is now using Nextflow DSL2, each process will be run wi | `deeptools` | 3.4.3 | 3.5.1 | | `pigz` | 2.3.4 | 2.6 | | `preseq` | 2.0.3 | 3.1.2 | -| `multiqc` | 1.9 | 1.12 | +| `multiqc` | 1.9 | 1.13a | | `r-base` | 3.6.1 | 4.0.3 | | `r-ggplot2` | 3.3.2 | 3.3.3 | | `bioconductor-deseq2` | 1.26.0 | 1.28.0 | diff --git a/modules/local/multiqc.nf b/modules/local/multiqc.nf index 4d6fe9f53..9d57e22c4 100644 --- a/modules/local/multiqc.nf +++ b/modules/local/multiqc.nf @@ -1,10 +1,10 @@ process MULTIQC { label 'process_medium' - conda (params.enable_conda ? "bioconda::multiqc=1.10.1" : null) + conda (params.enable_conda ? "bioconda::multiqc=1.13a" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? - 'https://depot.galaxyproject.org/singularity/multiqc:1.10.1--pyhdfd78af_1': - 'quay.io/biocontainers/multiqc:1.10.1--pyhdfd78af_1' }" + 'https://depot.galaxyproject.org/singularity/multiqc:1.13a--pyhdfd78af_1': + 'quay.io/biocontainers/multiqc:1.13a--pyhdfd78af_1' }" input: path multiqc_config From e84f6c517205be4e40b767f19e1e882d8c28e36f Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 10 Aug 2022 13:25:27 +0200 Subject: [PATCH 482/538] Add chromap to aws full test --- .github/workflows/awsfulltest.yml | 3 +-- 1 file changed, 1 insertion(+), 2 deletions(-) diff --git a/.github/workflows/awsfulltest.yml b/.github/workflows/awsfulltest.yml index 43c359a75..5a1c3622d 100644 --- a/.github/workflows/awsfulltest.yml +++ b/.github/workflows/awsfulltest.yml @@ -14,8 +14,7 @@ jobs: runs-on: ubuntu-latest strategy: matrix: - # aligner: ["bwa", "bowtie2", "chromap", "star"] //TODO uncomment when chromap implemented - aligner: ["bwa", "bowtie2", "star"] + aligner: ["bwa", "bowtie2", "chromap", "star"] steps: - name: Launch workflow via tower uses: nf-core/tower-action@v3 From 04459640210e641bf504a161c7f1a09a678109bb Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 10 Aug 2022 15:17:50 +0200 Subject: [PATCH 483/538] Remove duplicated item in version table and fix version --- CHANGELOG.md | 3 +-- 1 file changed, 1 insertion(+), 2 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 228444dfa..e2bb7412b 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -52,8 +52,7 @@ Note, since the pipeline is now using Nextflow DSL2, each process will be run wi | Dependency | Old version | New version | | ----------------------- | ----------- | ----------- | | `samtools` | 1.10 | 1.15.1 | -| `picard` | 2.23.1 | 2.26.10 | -| `picard` | 2.23.1 | 2.26.10 | +| `picard` | 2.23.1 | 2.27.4 | | `bamtools` | 2.5.1 | 2.5.2 | | `pysam` | 0.15.3 | 0.19.0 | | `bedtools` | 2.29.2 | 2.30.0 | From 6601012f0d022164e66379bd1d652580a989f406 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 10 Aug 2022 15:38:12 +0200 Subject: [PATCH 484/538] Add trimgalore new version to changelog --- CHANGELOG.md | 1 + 1 file changed, 1 insertion(+) diff --git a/CHANGELOG.md b/CHANGELOG.md index e2bb7412b..14e99be91 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -64,6 +64,7 @@ Note, since the pipeline is now using Nextflow DSL2, each process will be run wi | `r-base` | 3.6.1 | 4.0.3 | | `r-ggplot2` | 3.3.2 | 3.3.3 | | `bioconductor-deseq2` | 1.26.0 | 1.28.0 | +| `trim-galore` | 0.6.5 | 0.6.7 | | `r-optparse` | - | 1.7.1 | | `chromap` | - | 0.2.1 | | `bowtie2` | - | 2.4.4 | From 2344f276ab3ba5b6cc45ac49b493330b45269ee1 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 12 Aug 2022 12:27:35 +0200 Subject: [PATCH 485/538] Move ANNOTATE_BOOLEAN_PEAKS under skip_peak_annotation --- conf/modules.config | 26 ++++++++++++-------------- 1 file changed, 12 insertions(+), 14 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 9f65d6af7..7acf69e2f 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -581,20 +581,6 @@ if (!params.skip_peak_annotation) { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } - - withName: 'ANNOTATE_BOOLEAN_PEAKS' { - ext.prefix = { "${meta.id}_peaks" } - publishDir = [ - path: { [ - "${params.outdir}/${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus' - ].join('') }, - mode: params.publish_dir_mode, - saveAs: { filename -> filename.equals('versions.yml') ? null : filename } - ] - - } } if (!params.skip_peak_qc) { @@ -673,6 +659,18 @@ if (!params.skip_consensus_peaks) { saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } + withName: 'ANNOTATE_BOOLEAN_PEAKS' { + ext.prefix = { "${meta.id}_peaks" } + publishDir = [ + path: { [ + "${params.outdir}/${params.aligner}/mergedLibrary/macs2", + params.narrow_peak? '/narrowPeak' : '/broadPeak', + '/consensus' + ].join('') }, + mode: params.publish_dir_mode, + saveAs: { filename -> filename.equals('versions.yml') ? null : filename } + ] + } } } From b61074c51d52aa0ce03aaf4e87bdec03adc5d024 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 12 Aug 2022 13:10:09 +0200 Subject: [PATCH 486/538] Update parameters table --- CHANGELOG.md | 30 +++++++++++++++++++++--------- 1 file changed, 21 insertions(+), 9 deletions(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 14e99be91..8b2f3ae66 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -31,15 +31,27 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 ### Parameters -| Old parameter | New parameter | -| ---------------------- | ------------------ | -| `--clusterOptions` | | -| `--conda` | `--enable_conda` | -| | `--skip_qc` | -| | `--aligner` | -| | `--save_unaligned` | -| `--skip_diff_analysis` | `--skip_deseq2_qc` | -| | `--read_length` | +| Old parameter | New parameter | +| ---------------------- | ----------------------- | +| `--conda` | `--enable_conda` | +| `--skip_diff_analysis` | `--skip_deseq2_qc` | +| | `--skip_qc` | +| | `--aligner` | +| | `--save_unaligned` | +| | `--read_length` | +| | `--multiqc_title` | +| | `--gff` | +| | `--bowtie2_index` | +| | `--chromap_index` | +| | `--star_index` | +| | `--validate_params` | +| | `--show_hidden_params` | +| | `--config_profile_name` | +| `--clusterOptions` | | +| `--single_end` | | +| `--name` | | +| `--hostnames` | | + > **NB:** Parameter has been **updated** if both old and new parameter information is present. > **NB:** Parameter has been **added** if just the new parameter information is present. From 318e0605b9cfe103d62e97fa53a82cdb76d79c3e Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 12 Aug 2022 13:12:08 +0200 Subject: [PATCH 487/538] Make prettier happy --- CHANGELOG.md | 1 - 1 file changed, 1 deletion(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 8b2f3ae66..ad159051c 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -52,7 +52,6 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 | `--name` | | | `--hostnames` | | - > **NB:** Parameter has been **updated** if both old and new parameter information is present. > **NB:** Parameter has been **added** if just the new parameter information is present. > **NB:** Parameter has been **removed** if parameter information isn't present. From 67a9cdc6cdbebdd7ff75362232094e7294b15a75 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Mon, 15 Aug 2022 11:34:16 +0100 Subject: [PATCH 488/538] Fix pipeline logo --- docs/images/nf-core-chipseq_logo_dark.png | Bin 73947 -> 73955 bytes 1 file changed, 0 insertions(+), 0 deletions(-) diff --git a/docs/images/nf-core-chipseq_logo_dark.png b/docs/images/nf-core-chipseq_logo_dark.png index cf22a2e865ba247de7727c84ee2e990aa932803e..9f2b30100fd7ed5870367833ae6567d1dd97f407 100644 GIT binary patch delta 23 fcmcb8kmd0~mJLw}91IK!44y8IA)BKT8V>*fZT<+W delta 14 WcmaESkmdG4mJLw}o0Ae64*&o;s|RTS From d83f76fbfd308d13d88c99530a2ae044c2730958 Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Tue, 16 Aug 2022 23:21:57 +0200 Subject: [PATCH 489/538] Update .gitignore MIME-Version: 1.0 Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: 8bit Co-authored-by: Matthias Hörtenhuber --- .gitignore | 1 - 1 file changed, 1 deletion(-) diff --git a/.gitignore b/.gitignore index 5124c9ac7..1dcfbdcdc 100644 --- a/.gitignore +++ b/.gitignore @@ -3,6 +3,5 @@ work/ data/ results/ .DS_Store -testing/ testing* *.pyc From b54cdd53f0d5abe6b6075dc505aa82e64800d615 Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Tue, 16 Aug 2022 23:22:12 +0200 Subject: [PATCH 490/538] Update CHANGELOG.md MIME-Version: 1.0 Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: 8bit Co-authored-by: Matthias Hörtenhuber --- CHANGELOG.md | 1 - 1 file changed, 1 deletion(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index ad159051c..3178bb7e1 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -13,7 +13,6 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 - [[#128](https://github.com/nf-core/chipseq/issues/128)] - Filter files with no peaks to avoid errors in downstream processes - [[#220](https://github.com/nf-core/chipseq/issues/220)] - Fix `phantompeakqualtools` protection stack overflow error - [[#233](https://github.com/nf-core/chipseq/issues/233)] - Add `chromap` to the available aligners -- Port pipeline to the updated Nextflow DSL2 syntax adopted on nf-core/modules - Bump minimum Nextflow version from `21.04.0` -> `21.10.3` - Added `python3` shebang to appropriate scripts in `bin/` directory - [[#160](https://github.com/nf-core/chipseq/issues/160)] - Add `bowtie2` and `star` as available aligners, via the `--aligner` parameter From 63ee901ec97211a77fbd4df2e11b47c1cb42f41d Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Tue, 16 Aug 2022 23:25:56 +0200 Subject: [PATCH 491/538] Update CHANGELOG.md MIME-Version: 1.0 Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: 8bit Co-authored-by: Matthias Hörtenhuber --- CHANGELOG.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 3178bb7e1..98dd839c2 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -22,7 +22,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 - [nf-core/tools#1415](https://github.com/nf-core/tools/issues/1415) - Make `--outdir` a mandatory parameter - [[282](https://github.com/nf-core/chipseq/issues/282)] - Fix `genome.fa` publication for IGV. - [[280](https://github.com/nf-core/chipseq/issues/280)] - Update `macs_gsize` in `igenomes.config`, create a new `--read_length` parameter and implement the logic to calculate `--macs_gsize` when the parameter is missing -- Eliminate `if`s conditions from `deseq2_qc` and `macs2_consensus` (local module and use `ext.when` instead) +- Eliminate `if` conditions from `deseq2_qc` and `macs2_consensus` (local module and use `ext.when` instead) - Remove `deseq2` differential binding analysis of consensus peaks. - [[280](https://github.com/nf-core/chipseq/issues/291) - Filter paired-end files produced by `chromap` since the resulting `BAM` files can not be processed downstream. - Remove from the macs2 consensus publish directory since it can not be referred as input from the IGV process (meta.id not resolved at execution time) From bb103d74e3e6a01e88e349cbbbd2f99e6fd86461 Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Tue, 16 Aug 2022 23:26:41 +0200 Subject: [PATCH 492/538] Update assets/multiqc/deseq2_clustering_header.txt MIME-Version: 1.0 Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: 8bit Co-authored-by: Matthias Hörtenhuber --- assets/multiqc/deseq2_clustering_header.txt | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/assets/multiqc/deseq2_clustering_header.txt b/assets/multiqc/deseq2_clustering_header.txt index 3dd28211b..f7bb33d8f 100644 --- a/assets/multiqc/deseq2_clustering_header.txt +++ b/assets/multiqc/deseq2_clustering_header.txt @@ -1,6 +1,6 @@ #id: 'deseq2_clustering' #section_name: 'MERGED LIB: DESeq2 sample similarity' -#description: "is generated from clustering the Euclidean distances between +#description: "Matrix is generated from clustering with Euclidean distances between # DESeq2 # rlog values for each sample # in the deseq2_qc.r script." From a05e1aae9ae020150327068f1e7bed6f30a22a41 Mon Sep 17 00:00:00 2001 From: Jose Espinosa-Carrasco Date: Tue, 16 Aug 2022 23:27:02 +0200 Subject: [PATCH 493/538] Update assets/multiqc/deseq2_pca_header.txt MIME-Version: 1.0 Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: 8bit Co-authored-by: Matthias Hörtenhuber --- assets/multiqc/deseq2_pca_header.txt | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/assets/multiqc/deseq2_pca_header.txt b/assets/multiqc/deseq2_pca_header.txt index 55b0bbadf..250c1cb77 100644 --- a/assets/multiqc/deseq2_pca_header.txt +++ b/assets/multiqc/deseq2_pca_header.txt @@ -1,6 +1,6 @@ #id: 'deseq2_pca' #section_name: 'MERGED LIB: DESeq2 PCA plot' -#description: "PCA plot between samples in the experiment. +#description: "PCA plot of the samples in the experiment. # These values are calculated using DESeq2 # in the deseq2_qc.r script." #plot_type: 'scatter' From 13f0f3e342b70c4b049fc2123e841368ad4f68ff Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 17 Aug 2022 15:37:42 +0200 Subject: [PATCH 494/538] Update citations as suggested in review --- CITATIONS.md | 15 ++++----------- 1 file changed, 4 insertions(+), 11 deletions(-) diff --git a/CITATIONS.md b/CITATIONS.md index f432375d4..63188ca80 100644 --- a/CITATIONS.md +++ b/CITATIONS.md @@ -26,6 +26,10 @@ > Langmead, B. and Salzberg, S. L. 2012 Fast gapped-read alignment with Bowtie 2. Nature methods, 9(4), p. 357–359. doi: 10.1038/nmeth.1923. +- [Chromap](https://doi.org/10.1038/s41467-021-26865-w) + + > Zhang H, Song L, Wang X, Cheng H, Wang C, Meyer CA, Liu T, Tang M, Aluru S, Yue F, Liu XS and Li H. Fast alignment and preprocessing of chromatin profiles with Chromap. Nature communications. 2021, 12(1), 1-6. doi: 10.1038/s41467-021-26865-w + - [deepTools](https://www.ncbi.nlm.nih.gov/pubmed/27079975/) > Ramírez F, Ryan DP, Grüning B, Bhardwaj V, Kilpert F, Richter AS, Heyne S, Dündar F, Manke T. deepTools2: a next generation web server for deep-sequencing data analysis. Nucleic Acids Res. 2016 Jul 8;44(W1):W160-5. doi: 10.1093/nar/gkw257. Epub 2016 Apr 13. PubMed PMID: 27079975; PubMed Central PMCID: PMC4987876. @@ -83,10 +87,6 @@ > Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550. PubMed PMID: 25516281; PubMed Central PMCID: PMC4302049. -- [vsn](https://bioconductor.org/packages/release/bioc/html/vsn.html) - - > Wolfgang Huber, Anja von Heydebreck, Holger Sueltmann, Annemarie Poustka and Martin Vingron. Variance Stabilization Applied to Microarray Data Calibration and to the Quantification of Differential Expression. Bioinformatics 18, S96-S104 (2002). - - [UpSetR](https://CRAN.R-project.org/package=UpSetR) > Nils Gehlenborg (2017). UpSetR: A More Scalable Alternative to Venn and Euler Diagrams for Visualizing Intersecting Sets. @@ -107,10 +107,6 @@ > Raivo Kolde (2018). pheatmap: Pretty Heatmaps. -- [lattice](https://cran.r-project.org/web/packages/lattice/index.html) - - > Sarkar, Deepayan (2008) Lattice: Multivariate Data Visualization with R. Springer, New York. ISBN 978-0-387-75968-5. - - [RColorBrewer](https://CRAN.R-project.org/package=RColorBrewer) > Erich Neuwirth (2014). RColorBrewer: ColorBrewer Palettes. @@ -119,9 +115,6 @@ > Trevor L Davis (2018). optparse: Command Line Option Parser. -- [xfun](https://CRAN.R-project.org/package=xfun) - > Yihui Xie (2018). xfun: Miscellaneous Functions by 'Yihui Xie'. - ## Software packaging/containerisation tools - [Anaconda](https://anaconda.com) From 676ea1871a603c9e49fed4d7816ddea82f87824a Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 17 Aug 2022 16:02:01 +0200 Subject: [PATCH 495/538] Fix nf-core lint after accepted suggestion --- .gitignore | 1 + 1 file changed, 1 insertion(+) diff --git a/.gitignore b/.gitignore index 1dcfbdcdc..5124c9ac7 100644 --- a/.gitignore +++ b/.gitignore @@ -3,5 +3,6 @@ work/ data/ results/ .DS_Store +testing/ testing* *.pyc From 5239e9860283036e5957d1d33dd0cce32dacc497 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 17 Aug 2022 16:34:01 +0200 Subject: [PATCH 496/538] Remove differential analysis options --- nextflow_schema.json | 30 +++++++++++------------------- 1 file changed, 11 insertions(+), 19 deletions(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index ed9cf2007..6d26d9597 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -323,25 +323,6 @@ } } }, - "deseq_qc_options": { - "title": "Differential analysis options", - "type": "object", - "fa_icon": "fas fa-not-equal", - "description": "Options to adjust differential analysis criteria.", - "properties": { - "deseq2_vst": { - "type": "boolean", - "description": "Use vst transformation instead of rlog with DESeq2.", - "help_text": "See [DESeq2 docs](http://bioconductor.org/packages/devel/bioc/vignettes/DESeq2/inst/doc/DESeq2.html#data-transformations-and-visualization).", - "fa_icon": "fas fa-dolly" - }, - "skip_deseq2_qc": { - "type": "boolean", - "fa_icon": "fas fa-fast-forward", - "description": "Skip DESeq2 PCA and heatmap plotting." - } - } - }, "process_skipping_options": { "title": "Process skipping options", "type": "object", @@ -363,6 +344,12 @@ "description": "Skip Preseq.", "fa_icon": "fas fa-fast-forward" }, + "deseq2_vst": { + "type": "boolean", + "description": "Use vst transformation instead of rlog with DESeq2.", + "help_text": "See [DESeq2 docs](http://bioconductor.org/packages/devel/bioc/vignettes/DESeq2/inst/doc/DESeq2.html#data-transformations-and-visualization).", + "fa_icon": "fas fa-dolly" + }, "skip_plot_profile": { "type": "boolean", "description": "Skip deepTools plotProfile.", @@ -378,6 +365,11 @@ "description": "Skip Phantompeakqualtools.", "fa_icon": "fas fa-fast-forward" }, + "skip_deseq2_qc": { + "type": "boolean", + "fa_icon": "fas fa-fast-forward", + "description": "Skip DESeq2 PCA and heatmap plotting." + }, "skip_igv": { "type": "boolean", "description": "Skip IGV.", From c31ac79853e71c9e18368f74c72a6c7d5db336cc Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 17 Aug 2022 23:30:31 +0200 Subject: [PATCH 497/538] Remove deseq_qc_options key from schema --- nextflow_schema.json | 3 --- 1 file changed, 3 deletions(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index 6d26d9597..ea0721e1b 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -579,9 +579,6 @@ { "$ref": "#/definitions/peak_calling_options" }, - { - "$ref": "#/definitions/deseq_qc_options" - }, { "$ref": "#/definitions/process_skipping_options" }, From dd105182f5cbca8fa61e2faa1c6f16d7b2855bf6 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Wed, 17 Aug 2022 23:40:56 +0200 Subject: [PATCH 498/538] Remove samplesheet.csv --- assets/samplesheet.csv | 3 --- 1 file changed, 3 deletions(-) delete mode 100644 assets/samplesheet.csv diff --git a/assets/samplesheet.csv b/assets/samplesheet.csv deleted file mode 100644 index 5f653ab7b..000000000 --- a/assets/samplesheet.csv +++ /dev/null @@ -1,3 +0,0 @@ -sample,fastq_1,fastq_2 -SAMPLE_PAIRED_END,/path/to/fastq/files/AEG588A1_S1_L002_R1_001.fastq.gz,/path/to/fastq/files/AEG588A1_S1_L002_R2_001.fastq.gz -SAMPLE_SINGLE_END,/path/to/fastq/files/AEG588A4_S4_L003_R1_001.fastq.gz, From c31c2a934d58f415757e4d6a169b779c967873fd Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 26 Aug 2022 19:34:34 +0200 Subject: [PATCH 499/538] Add deseq and fix homer annotate peaks in multiqc --- modules/local/multiqc.nf | 3 +++ workflows/chipseq.nf | 9 ++++++--- 2 files changed, 9 insertions(+), 3 deletions(-) diff --git a/modules/local/multiqc.nf b/modules/local/multiqc.nf index 9d57e22c4..92824f01d 100644 --- a/modules/local/multiqc.nf +++ b/modules/local/multiqc.nf @@ -44,6 +44,9 @@ process MULTIQC { path ('featurecounts/*') + path ('deseq2/*') + path ('deseq2/*') + output: path "*multiqc_report.html", emit: report path "*_data" , emit: data diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 658a8b944..d22467392 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -582,6 +582,8 @@ workflow CHIPSEQ { ch_deseq2_pca_header, ch_deseq2_clustering_header ) + ch_deseq2_pca_multiqc = DESEQ2_QC.out.pca_multiqc + ch_deseq2_clustering_multiqc = DESEQ2_QC.out.dists_multiqc } } @@ -654,9 +656,10 @@ workflow CHIPSEQ { ch_custompeaks_frip_multiqc.collect{it[1]}.ifEmpty([]), ch_custompeaks_count_multiqc.collect{it[1]}.ifEmpty([]), - ch_plothomerannotatepeaks_multiqc.collect{it[1]}.ifEmpty([]), - ch_subreadfeaturecounts_multiqc.collect{it[1]}.ifEmpty([])//, - // path ('macs/consensus/*') from ch_macs_consensus_deseq_mqc.collect().ifEmpty([]) + ch_plothomerannotatepeaks_multiqc.collect().ifEmpty([]), + ch_subreadfeaturecounts_multiqc.collect{it[1]}.ifEmpty([]), + ch_deseq2_pca_multiqc.collect().ifEmpty([]), + ch_deseq2_clustering_multiqc.collect().ifEmpty([]) ) multiqc_report = MULTIQC.out.report.toList() } From f2eabfd563cb2de8a66bd96a360698ba43bb2e97 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 26 Aug 2022 19:39:22 +0200 Subject: [PATCH 500/538] Fix channel declaration --- workflows/chipseq.nf | 2 ++ 1 file changed, 2 insertions(+) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index d22467392..da6a58e6a 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -576,6 +576,8 @@ workflow CHIPSEQ { ch_subreadfeaturecounts_multiqc = SUBREAD_FEATURECOUNTS.out.summary ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first()) + ch_deseq2_pca_multiqc = Channel.empty() + ch_deseq2_clustering_multiqc = Channel.empty() if (!params.skip_deseq2_qc) { DESEQ2_QC ( SUBREAD_FEATURECOUNTS.out.counts, From 20a25bfbc8ba491b4273a0b01fe62d941c653d9f Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Fri, 26 Aug 2022 19:52:15 +0200 Subject: [PATCH 501/538] Declare channel before skip to avoid error --- workflows/chipseq.nf | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index da6a58e6a..eedccc5d5 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -506,7 +506,9 @@ workflow CHIPSEQ { // // Consensus peaks analysis // - ch_macs2_consensus_bed_lib = Channel.empty() + ch_macs2_consensus_bed_lib = Channel.empty() + ch_deseq2_pca_multiqc = Channel.empty() + ch_deseq2_clustering_multiqc = Channel.empty() if (!params.skip_consensus_peaks) { // Create channel: [ meta , [ peaks ] ] // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] @@ -576,8 +578,6 @@ workflow CHIPSEQ { ch_subreadfeaturecounts_multiqc = SUBREAD_FEATURECOUNTS.out.summary ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first()) - ch_deseq2_pca_multiqc = Channel.empty() - ch_deseq2_clustering_multiqc = Channel.empty() if (!params.skip_deseq2_qc) { DESEQ2_QC ( SUBREAD_FEATURECOUNTS.out.counts, From 4760fc77fa6bfa6b1429fb1df9cfebb6d87d7695 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Tue, 30 Aug 2022 09:54:45 +0200 Subject: [PATCH 502/538] Fix labels for deeptools plotfingerprint --- conf/modules.config | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/conf/modules.config b/conf/modules.config index 7acf69e2f..47784e03d 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -510,7 +510,7 @@ if (!params.skip_plot_fingerprint) { ext.args = { [ '--skipZeros', "--numberOfSamples $params.fingerprint_bins", - "--labels $meta.ip $meta.control" + "--labels $meta.id $meta.control" ].join(' ').trim() } ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ From 3e91dcd324876319a27567413d7f24b4772b0c8b Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Tue, 30 Aug 2022 13:31:08 +0000 Subject: [PATCH 503/538] Template update for nf-core/tools version 2.5 --- .editorconfig | 2 +- .github/PULL_REQUEST_TEMPLATE.md | 3 +- .github/workflows/ci.yml | 23 ++----- .github/workflows/linting.yml | 38 ++++++++++-- CHANGELOG.md | 2 +- CITATION.cff | 56 ++++++++++++++++++ README.md | 21 +++---- assets/email_template.txt | 1 - bin/check_samplesheet.py | 41 +++++++------ conf/base.config | 5 ++ docs/images/nf-core-chipseq_logo_dark.png | Bin 73947 -> 73955 bytes docs/usage.md | 12 ++-- lib/WorkflowChipseq.groovy | 5 +- lib/WorkflowMain.groovy | 9 ++- main.nf | 2 +- modules.json | 22 ++++--- .../templates/dumpsoftwareversions.py | 14 +++-- nextflow.config | 23 ++++++- 18 files changed, 186 insertions(+), 93 deletions(-) create mode 100644 CITATION.cff diff --git a/.editorconfig b/.editorconfig index b6b319077..b78de6e65 100644 --- a/.editorconfig +++ b/.editorconfig @@ -8,7 +8,7 @@ trim_trailing_whitespace = true indent_size = 4 indent_style = space -[*.{md,yml,yaml,html,css,scss,js}] +[*.{md,yml,yaml,html,css,scss,js,cff}] indent_size = 2 # These files are edited and tested upstream in nf-core/modules diff --git a/.github/PULL_REQUEST_TEMPLATE.md b/.github/PULL_REQUEST_TEMPLATE.md index 9595a3a41..8da27af0e 100644 --- a/.github/PULL_REQUEST_TEMPLATE.md +++ b/.github/PULL_REQUEST_TEMPLATE.md @@ -15,8 +15,7 @@ Learn more about contributing: [CONTRIBUTING.md](https://github.com/nf-core/chip - [ ] This comment contains a description of changes (with reason). - [ ] If you've fixed a bug or added code that should be tested, add tests! - - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md) - - [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. +- [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md)- [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. - [ ] Make sure your code lints (`nf-core lint`). - [ ] Ensure the test suite passes (`nextflow run . -profile test,docker --outdir `). - [ ] Usage Documentation in `docs/usage.md` is updated. diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 0596f36fc..cf99db7f7 100644 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -10,7 +10,6 @@ on: env: NXF_ANSI_LOG: false - CAPSULE_LOG: none jobs: test: @@ -20,27 +19,17 @@ jobs: runs-on: ubuntu-latest strategy: matrix: - # Nextflow versions - include: - # Test pipeline minimum Nextflow version - - NXF_VER: "21.10.3" - NXF_EDGE: "" - # Test latest edge release of Nextflow - - NXF_VER: "" - NXF_EDGE: "1" + NXF_VER: + - "21.10.3" + - "latest-everything" steps: - name: Check out pipeline code uses: actions/checkout@v2 - name: Install Nextflow - env: - NXF_VER: ${{ matrix.NXF_VER }} - # Uncomment only if the edge release is more recent than the latest stable release - # See https://github.com/nextflow-io/nextflow/issues/2467 - # NXF_EDGE: ${{ matrix.NXF_EDGE }} - run: | - wget -qO- get.nextflow.io | bash - sudo mv nextflow /usr/local/bin/ + uses: nf-core/setup-nextflow@v1 + with: + version: "${{ matrix.NXF_VER }}" - name: Run pipeline with test data # TODO nf-core: You can customise CI pipeline run tests as required diff --git a/.github/workflows/linting.yml b/.github/workflows/linting.yml index 77358dee7..8a5ce69b8 100644 --- a/.github/workflows/linting.yml +++ b/.github/workflows/linting.yml @@ -35,6 +35,36 @@ jobs: - name: Run Prettier --check run: prettier --check ${GITHUB_WORKSPACE} + PythonBlack: + runs-on: ubuntu-latest + steps: + - uses: actions/checkout@v2 + + - name: Check code lints with Black + uses: psf/black@stable + + # If the above check failed, post a comment on the PR explaining the failure + - name: Post PR comment + if: failure() + uses: mshick/add-pr-comment@v1 + with: + message: | + ## Python linting (`black`) is failing + + To keep the code consistent with lots of contributors, we run automated code consistency checks. + To fix this CI test, please run: + + * Install [`black`](https://black.readthedocs.io/en/stable/): `pip install black` + * Fix formatting errors in your pipeline: `black .` + + Once you push these changes the test should pass, and you can hide this comment :+1: + + We highly recommend setting up Black in your code editor so that this formatting is done automatically on save. Ask about it on Slack for help! + + Thanks again for your contribution! + repo-token: ${{ secrets.GITHUB_TOKEN }} + allow-repeats: false + nf-core: runs-on: ubuntu-latest steps: @@ -42,15 +72,11 @@ jobs: uses: actions/checkout@v2 - name: Install Nextflow - env: - CAPSULE_LOG: none - run: | - wget -qO- get.nextflow.io | bash - sudo mv nextflow /usr/local/bin/ + uses: nf-core/setup-nextflow@v1 - uses: actions/setup-python@v3 with: - python-version: "3.6" + python-version: "3.7" architecture: "x64" - name: Install dependencies diff --git a/CHANGELOG.md b/CHANGELOG.md index bcbe42c1b..ddd115381 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -3,7 +3,7 @@ The format is based on [Keep a Changelog](https://keepachangelog.com/en/1.0.0/) and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.html). -## v1.3.0dev - [date] +## v2.0.0 - [date] Initial release of nf-core/chipseq, created with the [nf-core](https://nf-co.re/) template. diff --git a/CITATION.cff b/CITATION.cff new file mode 100644 index 000000000..4533e2f28 --- /dev/null +++ b/CITATION.cff @@ -0,0 +1,56 @@ +cff-version: 1.2.0 +message: "If you use `nf-core tools` in your work, please cite the `nf-core` publication" +authors: + - family-names: Ewels + given-names: Philip + - family-names: Peltzer + given-names: Alexander + - family-names: Fillinger + given-names: Sven + - family-names: Patel + given-names: Harshil + - family-names: Alneberg + given-names: Johannes + - family-names: Wilm + given-names: Andreas + - family-names: Ulysse Garcia + given-names: Maxime + - family-names: Di Tommaso + given-names: Paolo + - family-names: Nahnsen + given-names: Sven +title: "The nf-core framework for community-curated bioinformatics pipelines." +version: 2.4.1 +doi: 10.1038/s41587-020-0439-x +date-released: 2022-05-16 +url: https://github.com/nf-core/tools +prefered-citation: + type: article + authors: + - family-names: Ewels + given-names: Philip + - family-names: Peltzer + given-names: Alexander + - family-names: Fillinger + given-names: Sven + - family-names: Patel + given-names: Harshil + - family-names: Alneberg + given-names: Johannes + - family-names: Wilm + given-names: Andreas + - family-names: Ulysse Garcia + given-names: Maxime + - family-names: Di Tommaso + given-names: Paolo + - family-names: Nahnsen + given-names: Sven + doi: 10.1038/s41587-020-0439-x + journal: nature biotechnology + start: 276 + end: 278 + title: "The nf-core framework for community-curated bioinformatics pipelines." + issue: 3 + volume: 38 + year: 2020 + url: https://dx.doi.org/10.1038/s41587-020-0439-x diff --git a/README.md b/README.md index 45ee3b4fc..095d129ce 100644 --- a/README.md +++ b/README.md @@ -1,19 +1,14 @@ # ![nf-core/chipseq](docs/images/nf-core-chipseq_logo_light.png#gh-light-mode-only) ![nf-core/chipseq](docs/images/nf-core-chipseq_logo_dark.png#gh-dark-mode-only) -[![GitHub Actions CI Status](https://github.com/nf-core/chipseq/workflows/nf-core%20CI/badge.svg)](https://github.com/nf-core/chipseq/actions?query=workflow%3A%22nf-core+CI%22) -[![GitHub Actions Linting Status](https://github.com/nf-core/chipseq/workflows/nf-core%20linting/badge.svg)](https://github.com/nf-core/chipseq/actions?query=workflow%3A%22nf-core+linting%22) -[![AWS CI](https://img.shields.io/badge/CI%20tests-full%20size-FF9900?logo=Amazon%20AWS)](https://nf-co.re/chipseq/results) -[![Cite with Zenodo](http://img.shields.io/badge/DOI-10.5281/zenodo.XXXXXXX-1073c8)](https://doi.org/10.5281/zenodo.XXXXXXX) +[![AWS CI](https://img.shields.io/badge/CI%20tests-full%20size-FF9900?labelColor=000000&logo=Amazon%20AWS)](https://nf-co.re/chipseq/results)[![Cite with Zenodo](http://img.shields.io/badge/DOI-10.5281/zenodo.XXXXXXX-1073c8?labelColor=000000)](https://doi.org/10.5281/zenodo.XXXXXXX) [![Nextflow](https://img.shields.io/badge/nextflow%20DSL2-%E2%89%A521.10.3-23aa62.svg)](https://www.nextflow.io/) -[![run with conda](http://img.shields.io/badge/run%20with-conda-3EB049?logo=anaconda)](https://docs.conda.io/en/latest/) -[![run with docker](https://img.shields.io/badge/run%20with-docker-0db7ed?logo=docker)](https://www.docker.com/) -[![run with singularity](https://img.shields.io/badge/run%20with-singularity-1d355c.svg)](https://sylabs.io/docs/) +[![run with conda](http://img.shields.io/badge/run%20with-conda-3EB049?labelColor=000000&logo=anaconda)](https://docs.conda.io/en/latest/) +[![run with docker](https://img.shields.io/badge/run%20with-docker-0db7ed?labelColor=000000&logo=docker)](https://www.docker.com/) +[![run with singularity](https://img.shields.io/badge/run%20with-singularity-1d355c.svg?labelColor=000000)](https://sylabs.io/docs/) [![Launch on Nextflow Tower](https://img.shields.io/badge/Launch%20%F0%9F%9A%80-Nextflow%20Tower-%234256e7)](https://tower.nf/launch?pipeline=https://github.com/nf-core/chipseq) -[![Get help on Slack](http://img.shields.io/badge/slack-nf--core%20%23chipseq-4A154B?logo=slack)](https://nfcore.slack.com/channels/chipseq) -[![Follow on Twitter](http://img.shields.io/badge/twitter-%40nf__core-1DA1F2?logo=twitter)](https://twitter.com/nf_core) -[![Watch on YouTube](http://img.shields.io/badge/youtube-nf--core-FF0000?logo=youtube)](https://www.youtube.com/c/nf-core) +[![Get help on Slack](http://img.shields.io/badge/slack-nf--core%20%23chipseq-4A154B?labelColor=000000&logo=slack)](https://nfcore.slack.com/channels/chipseq)[![Follow on Twitter](http://img.shields.io/badge/twitter-%40nf__core-1DA1F2?labelColor=000000&logo=twitter)](https://twitter.com/nf_core)[![Watch on YouTube](http://img.shields.io/badge/youtube-nf--core-FF0000?labelColor=000000&logo=youtube)](https://www.youtube.com/c/nf-core) ## Introduction @@ -25,7 +20,7 @@ The pipeline is built using [Nextflow](https://www.nextflow.io), a workflow tool -On release, automated continuous integration tests run the pipeline on a full-sized dataset on the AWS cloud infrastructure. This ensures that the pipeline runs on AWS, has sensible resource allocation defaults set to run on real-world datasets, and permits the persistent storage of results to benchmark between pipeline releases and other analysis sources. The results obtained from the full-sized test can be viewed on the [nf-core website](https://nf-co.re/chipseq/results). +On release, automated continuous integration tests run the pipeline on a full-sized dataset on the AWS cloud infrastructure. This ensures that the pipeline runs on AWS, has sensible resource allocation defaults set to run on real-world datasets, and permits the persistent storage of results to benchmark between pipeline releases and other analysis sources.The results obtained from the full-sized test can be viewed on the [nf-core website](https://nf-co.re/chipseq/results). ## Pipeline summary @@ -42,7 +37,7 @@ On release, automated continuous integration tests run the pipeline on a full-si 3. Download the pipeline and test it on a minimal dataset with a single command: - ```console + ```bash nextflow run nf-core/chipseq -profile test,YOURPROFILE --outdir ``` @@ -57,7 +52,7 @@ On release, automated continuous integration tests run the pipeline on a full-si - ```console + ```bash nextflow run nf-core/chipseq --input samplesheet.csv --outdir --genome GRCh37 -profile ``` diff --git a/assets/email_template.txt b/assets/email_template.txt index 6d35a6974..e1b785260 100644 --- a/assets/email_template.txt +++ b/assets/email_template.txt @@ -6,7 +6,6 @@ `._,._,' nf-core/chipseq v${version} ---------------------------------------------------- - Run Name: $runName <% if (success){ diff --git a/bin/check_samplesheet.py b/bin/check_samplesheet.py index 3652c63c8..9a8b89623 100755 --- a/bin/check_samplesheet.py +++ b/bin/check_samplesheet.py @@ -11,7 +11,6 @@ from collections import Counter from pathlib import Path - logger = logging.getLogger() @@ -79,13 +78,15 @@ def validate_and_transform(self, row): def _validate_sample(self, row): """Assert that the sample name exists and convert spaces to underscores.""" - assert len(row[self._sample_col]) > 0, "Sample input is required." + if len(row[self._sample_col]) <= 0: + raise AssertionError("Sample input is required.") # Sanitize samples slightly. row[self._sample_col] = row[self._sample_col].replace(" ", "_") def _validate_first(self, row): """Assert that the first FASTQ entry is non-empty and has the right format.""" - assert len(row[self._first_col]) > 0, "At least the first FASTQ file is required." + if len(row[self._first_col]) <= 0: + raise AssertionError("At least the first FASTQ file is required.") self._validate_fastq_format(row[self._first_col]) def _validate_second(self, row): @@ -97,36 +98,34 @@ def _validate_pair(self, row): """Assert that read pairs have the same file extension. Report pair status.""" if row[self._first_col] and row[self._second_col]: row[self._single_col] = False - assert ( - Path(row[self._first_col]).suffixes[-2:] == Path(row[self._second_col]).suffixes[-2:] - ), "FASTQ pairs must have the same file extensions." + if Path(row[self._first_col]).suffixes[-2:] != Path(row[self._second_col]).suffixes[-2:]: + raise AssertionError("FASTQ pairs must have the same file extensions.") else: row[self._single_col] = True def _validate_fastq_format(self, filename): """Assert that a given filename has one of the expected FASTQ extensions.""" - assert any(filename.endswith(extension) for extension in self.VALID_FORMATS), ( - f"The FASTQ file has an unrecognized extension: {filename}\n" - f"It should be one of: {', '.join(self.VALID_FORMATS)}" - ) + if not any(filename.endswith(extension) for extension in self.VALID_FORMATS): + raise AssertionError( + f"The FASTQ file has an unrecognized extension: {filename}\n" + f"It should be one of: {', '.join(self.VALID_FORMATS)}" + ) def validate_unique_samples(self): """ Assert that the combination of sample name and FASTQ filename is unique. - In addition to the validation, also rename the sample if more than one sample, - FASTQ file combination exists. + In addition to the validation, also rename all samples to have a suffix of _T{n}, where n is the + number of times the same sample exist, but with different FASTQ files, e.g., multiple runs per experiment. """ - assert len(self._seen) == len(self.modified), "The pair of sample name and FASTQ must be unique." - if len({pair[0] for pair in self._seen}) < len(self._seen): - counts = Counter(pair[0] for pair in self._seen) - seen = Counter() - for row in self.modified: - sample = row[self._sample_col] - seen[sample] += 1 - if counts[sample] > 1: - row[self._sample_col] = f"{sample}_T{seen[sample]}" + if len(self._seen) != len(self.modified): + raise AssertionError("The pair of sample name and FASTQ must be unique.") + seen = Counter() + for row in self.modified: + sample = row[self._sample_col] + seen[sample] += 1 + row[self._sample_col] = f"{sample}_T{seen[sample]}" def read_head(handle, num_lines=10): diff --git a/conf/base.config b/conf/base.config index 8231c4796..daf12c7c7 100644 --- a/conf/base.config +++ b/conf/base.config @@ -26,6 +26,11 @@ process { // adding in your local modules too. // TODO nf-core: Customise requirements for specific processes. // See https://www.nextflow.io/docs/latest/config.html#config-process-selectors + withLabel:process_single { + cpus = { check_max( 1 , 'cpus' ) } + memory = { check_max( 6.GB * task.attempt, 'memory' ) } + time = { check_max( 4.h * task.attempt, 'time' ) } + } withLabel:process_low { cpus = { check_max( 2 * task.attempt, 'cpus' ) } memory = { check_max( 12.GB * task.attempt, 'memory' ) } diff --git a/docs/images/nf-core-chipseq_logo_dark.png b/docs/images/nf-core-chipseq_logo_dark.png index cf22a2e865ba247de7727c84ee2e990aa932803e..9f2b30100fd7ed5870367833ae6567d1dd97f407 100644 GIT binary patch delta 23 fcmcb8kmd0~mJLw}91IK!44y8IA)BKT8V>*fZT<+W delta 14 WcmaESkmdG4mJLw}o0Ae64*&o;s|RTS diff --git a/docs/usage.md b/docs/usage.md index e6dc9daa9..997dfd2ce 100644 --- a/docs/usage.md +++ b/docs/usage.md @@ -12,7 +12,7 @@ You will need to create a samplesheet with information about the samples you would like to analyse before running the pipeline. Use this parameter to specify its location. It has to be a comma-separated file with 3 columns, and a header row as shown in the examples below. -```console +```bash --input '[path to samplesheet file]' ``` @@ -56,7 +56,7 @@ An [example samplesheet](../assets/samplesheet.csv) has been provided with the p The typical command for running the pipeline is as follows: -```console +```bash nextflow run nf-core/chipseq --input samplesheet.csv --outdir --genome GRCh37 -profile docker ``` @@ -64,9 +64,9 @@ This will launch the pipeline with the `docker` configuration profile. See below Note that the pipeline will create the following files in your working directory: -```console +```bash work # Directory containing the nextflow working files - # Finished results in specified location (defined with --outdir) + # Finished results in specified location (defined with --outdir) .nextflow_log # Log file from Nextflow # Other nextflow hidden files, eg. history of pipeline runs and old logs. ``` @@ -75,7 +75,7 @@ work # Directory containing the nextflow working files When you run the above command, Nextflow automatically pulls the pipeline code from GitHub and stores it as a cached version. When running the pipeline after this, it will always use the cached version if available - even if the pipeline has been updated since. To make sure that you're running the latest version of the pipeline, make sure that you regularly update the cached version of the pipeline: -```console +```bash nextflow pull nf-core/chipseq ``` @@ -251,6 +251,6 @@ Some HPC setups also allow you to run nextflow within a cluster job submitted yo In some cases, the Nextflow Java virtual machines can start to request a large amount of memory. We recommend adding the following line to your environment to limit this (typically in `~/.bashrc` or `~./bash_profile`): -```console +```bash NXF_OPTS='-Xms1g -Xmx4g' ``` diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index 547194f75..a5952af0c 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -10,6 +10,7 @@ class WorkflowChipseq { public static void initialise(params, log) { genomeExistsError(params, log) + if (!params.fasta) { log.error "Genome fasta file not specified with e.g. '--fasta genome.fa' or via a detectable config file." System.exit(1) @@ -41,9 +42,7 @@ class WorkflowChipseq { yaml_file_text += "data: |\n" yaml_file_text += "${summary_section}" return yaml_file_text - } - - // + }// // Exit pipeline if incorrect --genome key provided // private static void genomeExistsError(params, log) { diff --git a/lib/WorkflowMain.groovy b/lib/WorkflowMain.groovy index 0bf58e435..904824ae2 100755 --- a/lib/WorkflowMain.groovy +++ b/lib/WorkflowMain.groovy @@ -59,6 +59,7 @@ class WorkflowMain { } // Print parameter summary log to screen + log.info paramsSummaryLog(workflow, params, log) // Check that a -profile or Nextflow config has been provided to run the pipeline @@ -78,17 +79,15 @@ class WorkflowMain { System.exit(1) } } - // // Get attribute from genome config file e.g. fasta // - public static String getGenomeAttribute(params, attribute) { - def val = '' + public static Object getGenomeAttribute(params, attribute) { if (params.genomes && params.genome && params.genomes.containsKey(params.genome)) { if (params.genomes[ params.genome ].containsKey(attribute)) { - val = params.genomes[ params.genome ][ attribute ] + return params.genomes[ params.genome ][ attribute ] } } - return val + return null } } diff --git a/main.nf b/main.nf index cf50b1183..d6adc8513 100644 --- a/main.nf +++ b/main.nf @@ -4,7 +4,7 @@ nf-core/chipseq ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Github : https://github.com/nf-core/chipseq - Website: https://nf-co.re/chipseq +Website: https://nf-co.re/chipseq Slack : https://nfcore.slack.com/channels/chipseq ---------------------------------------------------------------------------------------- */ diff --git a/modules.json b/modules.json index 72584e8a4..db8387141 100644 --- a/modules.json +++ b/modules.json @@ -3,14 +3,20 @@ "homePage": "https://github.com/nf-core/chipseq", "repos": { "nf-core/modules": { - "custom/dumpsoftwareversions": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" - }, - "fastqc": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" - }, - "multiqc": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + "git_url": "https://github.com/nf-core/modules.git", + "modules": { + "custom/dumpsoftwareversions": { + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d", + "branch": "master" + }, + "fastqc": { + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d", + "branch": "master" + }, + "multiqc": { + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d", + "branch": "master" + } } } } diff --git a/modules/nf-core/modules/custom/dumpsoftwareversions/templates/dumpsoftwareversions.py b/modules/nf-core/modules/custom/dumpsoftwareversions/templates/dumpsoftwareversions.py index d13903925..787bdb7b1 100644 --- a/modules/nf-core/modules/custom/dumpsoftwareversions/templates/dumpsoftwareversions.py +++ b/modules/nf-core/modules/custom/dumpsoftwareversions/templates/dumpsoftwareversions.py @@ -1,9 +1,10 @@ #!/usr/bin/env python -import yaml import platform from textwrap import dedent +import yaml + def _make_versions_html(versions): html = [ @@ -58,11 +59,12 @@ def _make_versions_html(versions): for process, process_versions in versions_by_process.items(): module = process.split(":")[-1] try: - assert versions_by_module[module] == process_versions, ( - "We assume that software versions are the same between all modules. " - "If you see this error-message it means you discovered an edge-case " - "and should open an issue in nf-core/tools. " - ) + if versions_by_module[module] != process_versions: + raise AssertionError( + "We assume that software versions are the same between all modules. " + "If you see this error-message it means you discovered an edge-case " + "and should open an issue in nf-core/tools. " + ) except KeyError: versions_by_module[module] = process_versions diff --git a/nextflow.config b/nextflow.config index 6c5ab6b95..08da317e8 100644 --- a/nextflow.config +++ b/nextflow.config @@ -13,11 +13,11 @@ params { // Input options input = null + // References genome = null igenomes_base = 's3://ngi-igenomes/igenomes' igenomes_ignore = false - // MultiQC options multiqc_config = null multiqc_title = null @@ -37,6 +37,7 @@ params { schema_ignore_params = 'genomes' enable_conda = false + // Config options custom_config_version = 'master' custom_config_base = "https://raw.githubusercontent.com/nf-core/configs/${params.custom_config_version}" @@ -45,6 +46,7 @@ params { config_profile_url = null config_profile_name = null + // Max resource options // Defaults only, expecting to be overwritten max_memory = '128.GB' @@ -72,6 +74,7 @@ try { // } + profiles { debug { process.beforeScript = 'echo $HOSTNAME' } conda { @@ -82,6 +85,15 @@ profiles { shifter.enabled = false charliecloud.enabled = false } + mamba { + params.enable_conda = true + conda.useMamba = true + docker.enabled = false + singularity.enabled = false + podman.enabled = false + shifter.enabled = false + charliecloud.enabled = false + } docker { docker.enabled = true docker.userEmulation = true @@ -119,10 +131,16 @@ profiles { podman.enabled = false shifter.enabled = false } + gitpod { + executor.name = 'local' + executor.cpus = 16 + executor.memory = 60.GB + } test { includeConfig 'conf/test.config' } test_full { includeConfig 'conf/test_full.config' } } + // Load igenomes.config if required if (!params.igenomes_ignore) { includeConfig 'conf/igenomes.config' @@ -130,6 +148,7 @@ if (!params.igenomes_ignore) { params.genomes = [:] } + // Export these variables to prevent local Python/R libraries from conflicting with those in the container // The JULIA depot path has been adjusted to a fixed path `/usr/local/share/julia` that needs to be used for packages in the container. // See https://apeltzer.github.io/post/03-julia-lang-nextflow/ for details on that. Once we have a common agreement on where to keep Julia packages, this is adjustable. @@ -169,7 +188,7 @@ manifest { description = 'ChIP-seq peak-calling and differential analysis pipeline.' mainScript = 'main.nf' nextflowVersion = '!>=21.10.3' - version = '1.3.0dev' + version = '2.0.0' } // Load modules.config for DSL2 module specific options From d2d38eea061d496d2d53d2ad9e66a59784399c39 Mon Sep 17 00:00:00 2001 From: nf-core-bot Date: Thu, 1 Sep 2022 13:23:01 +0000 Subject: [PATCH 504/538] Template update for nf-core/tools version 2.5.1 --- bin/check_samplesheet.py | 9 ++++++--- pyproject.toml | 10 ++++++++++ 2 files changed, 16 insertions(+), 3 deletions(-) create mode 100644 pyproject.toml diff --git a/bin/check_samplesheet.py b/bin/check_samplesheet.py index 9a8b89623..11b155723 100755 --- a/bin/check_samplesheet.py +++ b/bin/check_samplesheet.py @@ -98,7 +98,9 @@ def _validate_pair(self, row): """Assert that read pairs have the same file extension. Report pair status.""" if row[self._first_col] and row[self._second_col]: row[self._single_col] = False - if Path(row[self._first_col]).suffixes[-2:] != Path(row[self._second_col]).suffixes[-2:]: + first_col_suffix = Path(row[self._first_col]).suffixes[-2:] + second_col_suffix = Path(row[self._second_col]).suffixes[-2:] + if first_col_suffix != second_col_suffix: raise AssertionError("FASTQ pairs must have the same file extensions.") else: row[self._single_col] = True @@ -157,7 +159,7 @@ def sniff_format(handle): handle.seek(0) sniffer = csv.Sniffer() if not sniffer.has_header(peek): - logger.critical(f"The given sample sheet does not appear to contain a header.") + logger.critical("The given sample sheet does not appear to contain a header.") sys.exit(1) dialect = sniffer.sniff(peek) return dialect @@ -195,7 +197,8 @@ def check_samplesheet(file_in, file_out): reader = csv.DictReader(in_handle, dialect=sniff_format(in_handle)) # Validate the existence of the expected header columns. if not required_columns.issubset(reader.fieldnames): - logger.critical(f"The sample sheet **must** contain the column headers: {', '.join(required_columns)}.") + req_cols = ", ".join(required_columns) + logger.critical(f"The sample sheet **must** contain these column headers: {req_cols}.") sys.exit(1) # Validate each row. checker = RowChecker() diff --git a/pyproject.toml b/pyproject.toml new file mode 100644 index 000000000..0d62beb6f --- /dev/null +++ b/pyproject.toml @@ -0,0 +1,10 @@ +# Config file for Python. Mostly used to configure linting of bin/check_samplesheet.py with Black. +# Should be kept the same as nf-core/tools to avoid fighting with template synchronisation. +[tool.black] +line-length = 120 +target_version = ["py37", "py38", "py39", "py310"] + +[tool.isort] +profile = "black" +known_first_party = ["nf_core"] +multi_line_output = 3 From a91436be493dea3067a831534046555b65a152a7 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Mon, 12 Sep 2022 12:42:58 +0100 Subject: [PATCH 505/538] Fix nf-core lint --- .github/PULL_REQUEST_TEMPLATE.md | 2 +- .nf-core.yml | 9 +- LICENSE | 2 +- modules.json | 225 ++++++++++++++++++------------- nextflow.config | 2 +- 5 files changed, 134 insertions(+), 106 deletions(-) diff --git a/.github/PULL_REQUEST_TEMPLATE.md b/.github/PULL_REQUEST_TEMPLATE.md index f3dbd188d..8da27af0e 100644 --- a/.github/PULL_REQUEST_TEMPLATE.md +++ b/.github/PULL_REQUEST_TEMPLATE.md @@ -17,7 +17,7 @@ Learn more about contributing: [CONTRIBUTING.md](https://github.com/nf-core/chip - [ ] If you've fixed a bug or added code that should be tested, add tests! - [ ] If you've added a new tool - have you followed the pipeline conventions in the [contribution docs](https://github.com/nf-core/chipseq/tree/master/.github/CONTRIBUTING.md)- [ ] If necessary, also make a PR on the nf-core/chipseq _branch_ on the [nf-core/test-datasets](https://github.com/nf-core/test-datasets) repository. - [ ] Make sure your code lints (`nf-core lint`). -- [ ] Ensure the test suite passes (`nextflow run . -profile test,docker` --outdir `). +- [ ] Ensure the test suite passes (`nextflow run . -profile test,docker --outdir `). - [ ] Usage Documentation in `docs/usage.md` is updated. - [ ] Output Documentation in `docs/output.md` is updated. - [ ] `CHANGELOG.md` is updated. diff --git a/.nf-core.yml b/.nf-core.yml index f1d2ac4ed..b1a7f0e91 100644 --- a/.nf-core.yml +++ b/.nf-core.yml @@ -1,8 +1 @@ -repository_type: pipeline -lint: - files_unchanged: - - .github/workflows/branch.yml - - .github/workflows/linting_comment.yml - - .github/workflows/linting.yml - - .github/PULL_REQUEST_TEMPLATE.md - - bin/check_samplesheet.py +repository_type: pipeline \ No newline at end of file diff --git a/LICENSE b/LICENSE index e6309f574..9ddb87a26 100644 --- a/LICENSE +++ b/LICENSE @@ -1,6 +1,6 @@ MIT License -Copyright (c) Philip Ewels, Jose Espinosa-Carrasco, Harshil Patel +Copyright (c) Espinosa-Carrasco J, Patel H, Wang C, Ewels P Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal diff --git a/modules.json b/modules.json index ad30c80a2..81c94b44a 100644 --- a/modules.json +++ b/modules.json @@ -3,101 +3,136 @@ "homePage": "https://github.com/nf-core/chipseq", "repos": { "nf-core/modules": { - "bowtie2/align": { - "git_sha": "848ee9a215d02d80be033bfa60881700f2bd914c" - }, - "bowtie2/build": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" - }, - "bwa/index": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" - }, - "bwa/mem": { - "git_sha": "4f5274c3de0c9521f5033893ff61057a74c45ba9" - }, - "chromap/chromap": { - "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" - }, - "chromap/index": { - "git_sha": "dbb46c9b635080b132bab4b8d5b9a14f0d1c22e7" - }, - "custom/dumpsoftwareversions": { - "git_sha": "e5b44499efcf6f7fb24874886bac60591c5d94dd" - }, - "custom/getchromsizes": { - "git_sha": "213403187932dbbdd936a04474cc8cd8abae7a08" - }, - "deeptools/computematrix": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" - }, - "deeptools/plotfingerprint": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" - }, - "deeptools/plotheatmap": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" - }, - "deeptools/plotprofile": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" - }, - "fastqc": { - "git_sha": "49b18b1639f4f7104187058866a8fab33332bdfe" - }, - "gffread": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" - }, - "gunzip": { - "git_sha": "fa37e0662690c4ec4260dae282fbce08777503e6" - }, - "homer/annotatepeaks": { - "git_sha": "233fa70811a03a4cecb2ece483b5c8396e2cee1d" - }, - "khmer/uniquekmers": { - "git_sha": "82fdff4fb4ce6cafcc028a7503da835427f35352" - }, - "macs2/callpeak": { - "git_sha": "f0800157544a82ae222931764483331a81812012" - }, - "phantompeakqualtools": { - "git_sha": "233fa70811a03a4cecb2ece483b5c8396e2cee1d" - }, - "picard/collectmultiplemetrics": { - "git_sha": "682f789f93070bd047868300dd018faf3d434e7c" - }, - "picard/markduplicates": { - "git_sha": "682f789f93070bd047868300dd018faf3d434e7c" - }, - "picard/mergesamfiles": { - "git_sha": "682f789f93070bd047868300dd018faf3d434e7c" - }, - "preseq/lcextrap": { - "git_sha": "7111e571cc5b6069de4673cd6165af680f17b4d7" - }, - "samtools/flagstat": { - "git_sha": "ecece498f10b47b7c9d06f53a310cea5811b4c5f" - }, - "samtools/idxstats": { - "git_sha": "ecece498f10b47b7c9d06f53a310cea5811b4c5f" - }, - "samtools/index": { - "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" - }, - "samtools/sort": { - "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" - }, - "samtools/stats": { - "git_sha": "f48a24770e24358e58de66e9b805a70d77cd154b" - }, - "subread/featurecounts": { - "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" - }, - "trimgalore": { - "git_sha": "85ec13ff1fc2196c5a507ea497de468101baabed" - }, - "ucsc/bedgraphtobigwig": { - "git_sha": "233fa70811a03a4cecb2ece483b5c8396e2cee1d" - }, - "untar": { - "git_sha": "51be617b1ca9bff973655eb899d591ed6ab253b5" + "git_url": "https://github.com/nf-core/modules.git", + "modules": { + "bowtie2/align": { + "branch": "master", + "git_sha": "848ee9a215d02d80be033bfa60881700f2bd914c" + }, + "bowtie2/build": { + "branch": "master", + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + }, + "bwa/index": { + "branch": "master", + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + }, + "bwa/mem": { + "branch": "master", + "git_sha": "4f5274c3de0c9521f5033893ff61057a74c45ba9" + }, + "chromap/chromap": { + "branch": "master", + "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" + }, + "chromap/index": { + "branch": "master", + "git_sha": "dbb46c9b635080b132bab4b8d5b9a14f0d1c22e7" + }, + "custom/dumpsoftwareversions": { + "branch": "master", + "git_sha": "e5b44499efcf6f7fb24874886bac60591c5d94dd" + }, + "custom/getchromsizes": { + "branch": "master", + "git_sha": "213403187932dbbdd936a04474cc8cd8abae7a08" + }, + "deeptools/computematrix": { + "branch": "master", + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + }, + "deeptools/plotfingerprint": { + "branch": "master", + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + }, + "deeptools/plotheatmap": { + "branch": "master", + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + }, + "deeptools/plotprofile": { + "branch": "master", + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + }, + "fastqc": { + "branch": "master", + "git_sha": "49b18b1639f4f7104187058866a8fab33332bdfe" + }, + "gffread": { + "branch": "master", + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + }, + "gunzip": { + "branch": "master", + "git_sha": "fa37e0662690c4ec4260dae282fbce08777503e6" + }, + "homer/annotatepeaks": { + "branch": "master", + "git_sha": "233fa70811a03a4cecb2ece483b5c8396e2cee1d" + }, + "khmer/uniquekmers": { + "branch": "master", + "git_sha": "82fdff4fb4ce6cafcc028a7503da835427f35352" + }, + "macs2/callpeak": { + "branch": "master", + "git_sha": "f0800157544a82ae222931764483331a81812012" + }, + "phantompeakqualtools": { + "branch": "master", + "git_sha": "233fa70811a03a4cecb2ece483b5c8396e2cee1d" + }, + "picard/collectmultiplemetrics": { + "branch": "master", + "git_sha": "682f789f93070bd047868300dd018faf3d434e7c" + }, + "picard/markduplicates": { + "branch": "master", + "git_sha": "682f789f93070bd047868300dd018faf3d434e7c" + }, + "picard/mergesamfiles": { + "branch": "master", + "git_sha": "682f789f93070bd047868300dd018faf3d434e7c" + }, + "preseq/lcextrap": { + "branch": "master", + "git_sha": "7111e571cc5b6069de4673cd6165af680f17b4d7" + }, + "samtools/flagstat": { + "branch": "master", + "git_sha": "ecece498f10b47b7c9d06f53a310cea5811b4c5f" + }, + "samtools/idxstats": { + "branch": "master", + "git_sha": "ecece498f10b47b7c9d06f53a310cea5811b4c5f" + }, + "samtools/index": { + "branch": "master", + "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" + }, + "samtools/sort": { + "branch": "master", + "git_sha": "897c33d5da084b61109500ee44c01da2d3e4e773" + }, + "samtools/stats": { + "branch": "master", + "git_sha": "f48a24770e24358e58de66e9b805a70d77cd154b" + }, + "subread/featurecounts": { + "branch": "master", + "git_sha": "e745e167c1020928ef20ea1397b6b4d230681b4d" + }, + "trimgalore": { + "branch": "master", + "git_sha": "85ec13ff1fc2196c5a507ea497de468101baabed" + }, + "ucsc/bedgraphtobigwig": { + "branch": "master", + "git_sha": "233fa70811a03a4cecb2ece483b5c8396e2cee1d" + }, + "untar": { + "branch": "master", + "git_sha": "51be617b1ca9bff973655eb899d591ed6ab253b5" + } } } } diff --git a/nextflow.config b/nextflow.config index 58cea5bfa..c2e329b6f 100644 --- a/nextflow.config +++ b/nextflow.config @@ -230,7 +230,7 @@ dag { manifest { name = 'nf-core/chipseq' - author = 'Jose Espinosa-Carrasco, Harshil Patel, Philip Ewels' + author = 'Espinosa-Carrasco J, Patel H, Wang C, Ewels P' homePage = 'https://github.com/nf-core/chipseq' description = 'ChIP-seq peak-calling and differential analysis pipeline.' mainScript = 'main.nf' From 4e83d3d524fbede21417e6ce829e7a19231d04d8 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Mon, 12 Sep 2022 12:44:19 +0100 Subject: [PATCH 506/538] Fix Black --- bin/bampe_rm_orphan.py | 62 ++++++++++------- bin/check_samplesheet.py | 21 ++---- bin/igv_files_to_session.py | 105 ++++++++++++++++++++--------- bin/macs2_merged_expand.py | 129 +++++++++++++++++++++++++----------- 4 files changed, 207 insertions(+), 110 deletions(-) diff --git a/bin/bampe_rm_orphan.py b/bin/bampe_rm_orphan.py index 5de45ea65..4ab9935b8 100755 --- a/bin/bampe_rm_orphan.py +++ b/bin/bampe_rm_orphan.py @@ -17,17 +17,25 @@ ############################################ ############################################ -Description = 'Remove singleton reads from paired-end BAM file i.e if read1 is present in BAM file without read 2 and vice versa.' +Description = ( + "Remove singleton reads from paired-end BAM file i.e if read1 is present in BAM file without read 2 and vice versa." +) Epilog = """Example usage: bampe_rm_orphan.py """ argParser = argparse.ArgumentParser(description=Description, epilog=Epilog) ## REQUIRED PARAMETERS -argParser.add_argument('BAM_INPUT_FILE', help="Input BAM file sorted by name.") -argParser.add_argument('BAM_OUTPUT_FILE', help="Output BAM file sorted by name.") +argParser.add_argument("BAM_INPUT_FILE", help="Input BAM file sorted by name.") +argParser.add_argument("BAM_OUTPUT_FILE", help="Output BAM file sorted by name.") ## OPTIONAL PARAMETERS -argParser.add_argument('-fr', '--only_fr_pairs', dest="ONLY_FR_PAIRS", help="Only keeps pairs that are in FR orientation on same chromosome.",action='store_true') +argParser.add_argument( + "-fr", + "--only_fr_pairs", + dest="ONLY_FR_PAIRS", + help="Only keeps pairs that are in FR orientation on same chromosome.", + action="store_true", +) args = argParser.parse_args() ############################################ @@ -36,6 +44,7 @@ ############################################ ############################################ + def makedir(path): if not len(path) == 0: @@ -45,20 +54,25 @@ def makedir(path): if exception.errno != errno.EEXIST: raise + ############################################ ############################################ ## MAIN FUNCTION ############################################ ############################################ -def bampe_rm_orphan(BAMIn,BAMOut,onlyFRPairs=False): + +def bampe_rm_orphan(BAMIn, BAMOut, onlyFRPairs=False): ## SETUP DIRECTORY/FILE STRUCTURE OutDir = os.path.dirname(BAMOut) makedir(OutDir) ## COUNT VARIABLES - totalReads = 0; totalOutputPairs = 0; totalSingletons = 0; totalImproperPairs = 0 + totalReads = 0 + totalOutputPairs = 0 + totalSingletons = 0 + totalImproperPairs = 0 ## ITERATE THROUGH BAM FILE EOF = 0 @@ -69,7 +83,8 @@ def bampe_rm_orphan(BAMIn,BAMOut,onlyFRPairs=False): for read in iter: totalReads += 1 if currRead.qname == read.qname: - pair1 = currRead; pair2 = read + pair1 = currRead + pair2 = read ## FILTER FOR READS ON SAME CHROMOSOME IN FR ORIENTATION if onlyFRPairs: @@ -125,30 +140,31 @@ def bampe_rm_orphan(BAMIn,BAMOut,onlyFRPairs=False): SAMFin.close() SAMFout.close() - LogFile = os.path.join(OutDir,'%s_bampe_rm_orphan.log' % (os.path.basename(BAMOut[:-4]))) - SamLogFile = open(LogFile,'w') - SamLogFile.write('\n##############################\n') - SamLogFile.write('FILES/DIRECTORIES') - SamLogFile.write('\n##############################\n\n') - SamLogFile.write('Input File: ' + BAMIn + '\n') - SamLogFile.write('Output File: ' + BAMOut + '\n') - SamLogFile.write('\n##############################\n') - SamLogFile.write('OVERALL COUNTS') - SamLogFile.write('\n##############################\n\n') - SamLogFile.write('Total Input Reads = ' + str(totalReads) + '\n') - SamLogFile.write('Total Output Pairs = ' + str(totalOutputPairs) + '\n') - SamLogFile.write('Total Singletons Excluded = ' + str(totalSingletons) + '\n') - SamLogFile.write('Total Improper Pairs Excluded = ' + str(totalImproperPairs) + '\n') - SamLogFile.write('\n##############################\n') + LogFile = os.path.join(OutDir, "%s_bampe_rm_orphan.log" % (os.path.basename(BAMOut[:-4]))) + SamLogFile = open(LogFile, "w") + SamLogFile.write("\n##############################\n") + SamLogFile.write("FILES/DIRECTORIES") + SamLogFile.write("\n##############################\n\n") + SamLogFile.write("Input File: " + BAMIn + "\n") + SamLogFile.write("Output File: " + BAMOut + "\n") + SamLogFile.write("\n##############################\n") + SamLogFile.write("OVERALL COUNTS") + SamLogFile.write("\n##############################\n\n") + SamLogFile.write("Total Input Reads = " + str(totalReads) + "\n") + SamLogFile.write("Total Output Pairs = " + str(totalOutputPairs) + "\n") + SamLogFile.write("Total Singletons Excluded = " + str(totalSingletons) + "\n") + SamLogFile.write("Total Improper Pairs Excluded = " + str(totalImproperPairs) + "\n") + SamLogFile.write("\n##############################\n") SamLogFile.close() + ############################################ ############################################ ## RUN FUNCTION ############################################ ############################################ -bampe_rm_orphan(BAMIn=args.BAM_INPUT_FILE,BAMOut=args.BAM_OUTPUT_FILE,onlyFRPairs=args.ONLY_FR_PAIRS) +bampe_rm_orphan(BAMIn=args.BAM_INPUT_FILE, BAMOut=args.BAM_OUTPUT_FILE, onlyFRPairs=args.ONLY_FR_PAIRS) ############################################ ############################################ diff --git a/bin/check_samplesheet.py b/bin/check_samplesheet.py index 1cc8a5939..eaf0d24c8 100755 --- a/bin/check_samplesheet.py +++ b/bin/check_samplesheet.py @@ -55,9 +55,7 @@ def check_samplesheet(file_in, file_out): HEADER = ["sample", "fastq_1", "fastq_2", "antibody", "control"] header = [x.strip('"') for x in fin.readline().strip().split(",")] if header[: len(HEADER)] != HEADER: - print( - f"ERROR: Please check samplesheet header -> {','.join(header)} != {','.join(HEADER)}" - ) + print(f"ERROR: Please check samplesheet header -> {','.join(header)} != {','.join(HEADER)}") sys.exit(1) ## Check sample entries @@ -82,9 +80,7 @@ def check_samplesheet(file_in, file_out): ## Check sample name entries sample, fastq_1, fastq_2, antibody, control = lspl[: len(HEADER)] if sample.find(" ") != -1: - print( - f"WARNING: Spaces have been replaced by underscores for sample: {sample}" - ) + print(f"WARNING: Spaces have been replaced by underscores for sample: {sample}") sample = sample.replace(" ", "_") if not sample: print_error("Sample entry has not been specified!", "Line", line) @@ -104,9 +100,7 @@ def check_samplesheet(file_in, file_out): ## Check antibody and control columns have valid values if antibody: if antibody.find(" ") != -1: - print( - f"WARNING: Spaces have been replaced by underscores for antibody: {antibody}" - ) + print(f"WARNING: Spaces have been replaced by underscores for antibody: {antibody}") antibody = antibody.replace(" ", "_") if not control: print_error( @@ -116,9 +110,7 @@ def check_samplesheet(file_in, file_out): ) if control: if control.find(" ") != -1: - print( - f"WARNING: Spaces have been replaced by underscores for control: {control}" - ) + print(f"WARNING: Spaces have been replaced by underscores for control: {control}") control = control.replace(" ", "_") if not antibody: print_error( @@ -166,10 +158,7 @@ def check_samplesheet(file_in, file_out): for sample in sorted(sample_mapping_dict.keys()): ## Check that multiple runs of the same sample are of the same datatype i.e. single-end / paired-end - if not all( - x[0] == sample_mapping_dict[sample][0][0] - for x in sample_mapping_dict[sample] - ): + if not all(x[0] == sample_mapping_dict[sample][0][0] for x in sample_mapping_dict[sample]): print_error( f"Multiple runs of a sample must be of the same datatype i.e. single-end or paired-end!", "Sample", diff --git a/bin/igv_files_to_session.py b/bin/igv_files_to_session.py index adfe8f7e2..ce1fac70f 100755 --- a/bin/igv_files_to_session.py +++ b/bin/igv_files_to_session.py @@ -22,12 +22,23 @@ argParser = argparse.ArgumentParser(description=Description, epilog=Epilog) ## REQUIRED PARAMETERS -argParser.add_argument('XML_OUT', help="XML output file.") -argParser.add_argument('LIST_FILE', help="Tab-delimited file containing two columns i.e. file_name\tcolour. Header isnt required.") -argParser.add_argument('GENOME', help="Full path to genome fasta file or shorthand for genome available in IGV e.g. hg19.") +argParser.add_argument("XML_OUT", help="XML output file.") +argParser.add_argument( + "LIST_FILE", help="Tab-delimited file containing two columns i.e. file_name\tcolour. Header isnt required." +) +argParser.add_argument( + "GENOME", help="Full path to genome fasta file or shorthand for genome available in IGV e.g. hg19." +) ## OPTIONAL PARAMETERS -argParser.add_argument('-pp', '--path_prefix', type=str, dest="PATH_PREFIX", default='', help="Path prefix to be added at beginning of all files in input list file.") +argParser.add_argument( + "-pp", + "--path_prefix", + type=str, + dest="PATH_PREFIX", + default="", + help="Path prefix to be added at beginning of all files in input list file.", +) args = argParser.parse_args() ############################################ @@ -36,6 +47,7 @@ ############################################ ############################################ + def makedir(path): if not len(path) == 0: @@ -45,76 +57,103 @@ def makedir(path): if exception.errno != errno.EEXIST: raise + ############################################ ############################################ ## MAIN FUNCTION ############################################ ############################################ -def igv_files_to_session(XMLOut,ListFile,Genome,PathPrefix=''): + +def igv_files_to_session(XMLOut, ListFile, Genome, PathPrefix=""): makedir(os.path.dirname(XMLOut)) fileList = [] - fin = open(ListFile,'r') + fin = open(ListFile, "r") while True: line = fin.readline() if line: - ifile,colour = line.strip().split('\t') + ifile, colour = line.strip().split("\t") if len(colour.strip()) == 0: - colour = '0,0,178' - fileList.append((PathPrefix.strip()+ifile,colour)) + colour = "0,0,178" + fileList.append((PathPrefix.strip() + ifile, colour)) else: break fout.close() ## ADD RESOURCES SECTION - XMLStr = '\n' + XMLStr = '\n' XMLStr += '\n' % (Genome) - XMLStr += '\t\n' - for ifile,colour in fileList: + XMLStr += "\t\n" + for ifile, colour in fileList: XMLStr += '\t\t\n' % (ifile) - XMLStr += '\t\n' + XMLStr += "\t\n" ## ADD PANEL SECTION XMLStr += '\t\n' - for ifile,colour in fileList: + for ifile, colour in fileList: extension = os.path.splitext(ifile)[1].lower() - if extension in ['.bed','.broadpeak','.narrowpeak']: - XMLStr += '\t\t\n' + % (ifile, os.path.basename(ifile)) + ) + elif extension in [".bw", ".bigwig", ".tdf"]: + XMLStr += ( + '\t\t\n' + % (ifile, os.path.basename(ifile)) + ) XMLStr += '\t\t\t\n' - XMLStr += '\t\t\n' - elif extension in ['.gtf']: - XMLStr += '\t\t\n' + % (ifile, os.path.basename(ifile)) + ) + elif extension in [".bam"]: pass else: - XMLStr += '\t\t\n' + % (ifile, os.path.basename(ifile)) + ) + + XMLStr += "\t\n" + # XMLStr += '\t\n\t\t\n\t\t\n\t\t\n\t\n' + XMLStr += "" + XMLOut = open(XMLOut, "w") XMLOut.write(XMLStr) XMLOut.close() + ############################################ ############################################ ## RUN FUNCTION ############################################ ############################################ -igv_files_to_session(XMLOut=args.XML_OUT,ListFile=args.LIST_FILE,Genome=args.GENOME,PathPrefix=args.PATH_PREFIX) +igv_files_to_session(XMLOut=args.XML_OUT, ListFile=args.LIST_FILE, Genome=args.GENOME, PathPrefix=args.PATH_PREFIX) ############################################ ############################################ diff --git a/bin/macs2_merged_expand.py b/bin/macs2_merged_expand.py index 0aa184757..aa401123f 100755 --- a/bin/macs2_merged_expand.py +++ b/bin/macs2_merged_expand.py @@ -16,19 +16,35 @@ ############################################ ############################################ -Description = 'Add sample boolean files and aggregate columns from merged MACS narrow or broad peak file.' +Description = "Add sample boolean files and aggregate columns from merged MACS narrow or broad peak file." Epilog = """Example usage: python macs2_merged_expand.py --is_narrow_peak --min_replicates 1""" argParser = argparse.ArgumentParser(description=Description, epilog=Epilog) ## REQUIRED PARAMETERS -argParser.add_argument('MERGED_INTERVAL_FILE', help="Merged MACS2 interval file created using linux sort and mergeBed.") -argParser.add_argument('SAMPLE_NAME_LIST', help="Comma-separated list of sample names as named in individual MACS2 broadPeak/narrowPeak output file e.g. SAMPLE_R1 for SAMPLE_R1_peak_1.") -argParser.add_argument('OUTFILE', help="Full path to output directory.") +argParser.add_argument("MERGED_INTERVAL_FILE", help="Merged MACS2 interval file created using linux sort and mergeBed.") +argParser.add_argument( + "SAMPLE_NAME_LIST", + help="Comma-separated list of sample names as named in individual MACS2 broadPeak/narrowPeak output file e.g. SAMPLE_R1 for SAMPLE_R1_peak_1.", +) +argParser.add_argument("OUTFILE", help="Full path to output directory.") ## OPTIONAL PARAMETERS -argParser.add_argument('-in', '--is_narrow_peak', dest="IS_NARROW_PEAK", help="Whether merged interval file was generated from narrow or broad peak files (default: False).",action='store_true') -argParser.add_argument('-mr', '--min_replicates', type=int, dest="MIN_REPLICATES", default=1, help="Minumum number of replicates per sample required to contribute to merged peak (default: 1).") +argParser.add_argument( + "-in", + "--is_narrow_peak", + dest="IS_NARROW_PEAK", + help="Whether merged interval file was generated from narrow or broad peak files (default: False).", + action="store_true", +) +argParser.add_argument( + "-mr", + "--min_replicates", + type=int, + dest="MIN_REPLICATES", + default=1, + help="Minumum number of replicates per sample required to contribute to merged peak (default: 1).", +) args = argParser.parse_args() ############################################ @@ -37,6 +53,7 @@ ############################################ ############################################ + def makedir(path): if not len(path) == 0: @@ -46,6 +63,7 @@ def makedir(path): if exception.errno != errno.EEXIST: raise + ############################################ ############################################ ## MAIN FUNCTION @@ -58,36 +76,50 @@ def makedir(path): ## 2) narrowPeak ## sort -k1,1 -k2,2n | mergeBed -c 2,3,4,5,6,7,8,9,10 -o collapse,collapse,collapse,collapse,collapse,collapse,collapse,collapse,collapse > merged_peaks.txt -def macs2_merged_expand(MergedIntervalTxtFile,SampleNameList,OutFile,isNarrow=False,minReplicates=1): + +def macs2_merged_expand(MergedIntervalTxtFile, SampleNameList, OutFile, isNarrow=False, minReplicates=1): makedir(os.path.dirname(OutFile)) combFreqDict = {} totalOutIntervals = 0 SampleNameList = sorted(SampleNameList) - fin = open(MergedIntervalTxtFile,'r') - fout = open(OutFile,'w') - oFields = ['chr','start','end','interval_id','num_peaks','num_samples'] + [x+'.bool' for x in SampleNameList] + [x+'.fc' for x in SampleNameList] + [x+'.qval' for x in SampleNameList] + [x+'.pval' for x in SampleNameList] + [x+'.start' for x in SampleNameList] + [x+'.end' for x in SampleNameList] + fin = open(MergedIntervalTxtFile, "r") + fout = open(OutFile, "w") + oFields = ( + ["chr", "start", "end", "interval_id", "num_peaks", "num_samples"] + + [x + ".bool" for x in SampleNameList] + + [x + ".fc" for x in SampleNameList] + + [x + ".qval" for x in SampleNameList] + + [x + ".pval" for x in SampleNameList] + + [x + ".start" for x in SampleNameList] + + [x + ".end" for x in SampleNameList] + ) if isNarrow: - oFields += [x+'.summit' for x in SampleNameList] - fout.write('\t'.join(oFields) + '\n') + oFields += [x + ".summit" for x in SampleNameList] + fout.write("\t".join(oFields) + "\n") while True: line = fin.readline() if line: - lspl = line.strip().split('\t') - - chromID = lspl[0]; mstart = int(lspl[1]); mend = int(lspl[2]); - starts = [int(x) for x in lspl[3].split(',')]; ends = [int(x) for x in lspl[4].split(',')] - names = lspl[5].split(','); fcs = [float(x) for x in lspl[8].split(',')] - pvals = [float(x) for x in lspl[9].split(',')]; qvals = [float(x) for x in lspl[10].split(',')] + lspl = line.strip().split("\t") + + chromID = lspl[0] + mstart = int(lspl[1]) + mend = int(lspl[2]) + starts = [int(x) for x in lspl[3].split(",")] + ends = [int(x) for x in lspl[4].split(",")] + names = lspl[5].split(",") + fcs = [float(x) for x in lspl[8].split(",")] + pvals = [float(x) for x in lspl[9].split(",")] + qvals = [float(x) for x in lspl[10].split(",")] summits = [] if isNarrow: - summits = [int(x) for x in lspl[11].split(',')] + summits = [int(x) for x in lspl[11].split(",")] ## GROUP SAMPLES BY REMOVING TRAILING *_R* groupDict = {} - for sID in ['_'.join(x.split('_')[:-2]) for x in names]: - gID = '_'.join(sID.split('_')[:-1]) + for sID in ["_".join(x.split("_")[:-2]) for x in names]: + gID = "_".join(sID.split("_")[:-1]) if gID not in groupDict: groupDict[gID] = [] if sID not in groupDict[gID]: @@ -95,14 +127,19 @@ def macs2_merged_expand(MergedIntervalTxtFile,SampleNameList,OutFile,isNarrow=Fa ## GET SAMPLES THAT PASS REPLICATE THRESHOLD passRepThreshList = [] - for gID,sIDs in groupDict.items(): + for gID, sIDs in groupDict.items(): if len(sIDs) >= minReplicates: passRepThreshList += sIDs ## GET VALUES FROM INDIVIDUAL PEAK SETS - fcDict = {}; qvalDict = {}; pvalDict = {}; startDict = {}; endDict = {}; summitDict = {} + fcDict = {} + qvalDict = {} + pvalDict = {} + startDict = {} + endDict = {} + summitDict = {} for idx in range(len(names)): - sample = '_'.join(names[idx].split('_')[:-2]) + sample = "_".join(names[idx].split("_")[:-2]) if sample in passRepThreshList: if sample not in fcDict: fcDict[sample] = [] @@ -127,16 +164,25 @@ def macs2_merged_expand(MergedIntervalTxtFile,SampleNameList,OutFile,isNarrow=Fa samples = sorted(fcDict.keys()) if samples != []: numSamples = len(samples) - boolList = ['TRUE' if x in samples else 'FALSE' for x in SampleNameList] - fcList = [';'.join(fcDict[x]) if x in samples else 'NA' for x in SampleNameList] - qvalList = [';'.join(qvalDict[x]) if x in samples else 'NA' for x in SampleNameList] - pvalList = [';'.join(pvalDict[x]) if x in samples else 'NA' for x in SampleNameList] - startList = [';'.join(startDict[x]) if x in samples else 'NA' for x in SampleNameList] - endList = [';'.join(endDict[x]) if x in samples else 'NA' for x in SampleNameList] - oList = [str(x) for x in [chromID,mstart,mend,'Interval_'+str(totalOutIntervals+1),len(names),numSamples]+boolList+fcList+qvalList+pvalList+startList+endList] + boolList = ["TRUE" if x in samples else "FALSE" for x in SampleNameList] + fcList = [";".join(fcDict[x]) if x in samples else "NA" for x in SampleNameList] + qvalList = [";".join(qvalDict[x]) if x in samples else "NA" for x in SampleNameList] + pvalList = [";".join(pvalDict[x]) if x in samples else "NA" for x in SampleNameList] + startList = [";".join(startDict[x]) if x in samples else "NA" for x in SampleNameList] + endList = [";".join(endDict[x]) if x in samples else "NA" for x in SampleNameList] + oList = [ + str(x) + for x in [chromID, mstart, mend, "Interval_" + str(totalOutIntervals + 1), len(names), numSamples] + + boolList + + fcList + + qvalList + + pvalList + + startList + + endList + ] if isNarrow: - oList += [';'.join(summitDict[x]) if x in samples else 'NA' for x in SampleNameList] - fout.write('\t'.join(oList) + '\n') + oList += [";".join(summitDict[x]) if x in samples else "NA" for x in SampleNameList] + fout.write("\t".join(oList) + "\n") tsamples = tuple(sorted(samples)) if tsamples not in combFreqDict: @@ -151,19 +197,26 @@ def macs2_merged_expand(MergedIntervalTxtFile,SampleNameList,OutFile,isNarrow=Fa ## WRITE FILE FOR INTERVAL INTERSECT ACROSS SAMPLES. ## COMPATIBLE WITH UPSETR PACKAGE. - fout = open(OutFile[:-4]+'.intersect.txt','w') - combFreqItems = sorted([(combFreqDict[x],x) for x in combFreqDict.keys()],reverse=True) - for k,v in combFreqItems: - fout.write('%s\t%s\n' % ('&'.join(v),k)) + fout = open(OutFile[:-4] + ".intersect.txt", "w") + combFreqItems = sorted([(combFreqDict[x], x) for x in combFreqDict.keys()], reverse=True) + for k, v in combFreqItems: + fout.write("%s\t%s\n" % ("&".join(v), k)) fout.close() + ############################################ ############################################ ## RUN FUNCTION ############################################ ############################################ -macs2_merged_expand(MergedIntervalTxtFile=args.MERGED_INTERVAL_FILE,SampleNameList=args.SAMPLE_NAME_LIST.split(','),OutFile=args.OUTFILE,isNarrow=args.IS_NARROW_PEAK,minReplicates=args.MIN_REPLICATES) +macs2_merged_expand( + MergedIntervalTxtFile=args.MERGED_INTERVAL_FILE, + SampleNameList=args.SAMPLE_NAME_LIST.split(","), + OutFile=args.OUTFILE, + isNarrow=args.IS_NARROW_PEAK, + minReplicates=args.MIN_REPLICATES, +) ############################################ ############################################ From c82f2f7f7f04215929d141256934ea5efb050251 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Mon, 12 Sep 2022 12:49:01 +0100 Subject: [PATCH 507/538] Fix Prettier --- .nf-core.yml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/.nf-core.yml b/.nf-core.yml index b1a7f0e91..3805dc81c 100644 --- a/.nf-core.yml +++ b/.nf-core.yml @@ -1 +1 @@ -repository_type: pipeline \ No newline at end of file +repository_type: pipeline From 023c1be3cd3c90767505ff0f61a846ebe5eaa0e1 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Mon, 12 Sep 2022 13:29:50 +0100 Subject: [PATCH 508/538] Fix indent in main.nf --- main.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/main.nf b/main.nf index 969542d9e..9baf7cb86 100755 --- a/main.nf +++ b/main.nf @@ -4,7 +4,7 @@ nf-core/chipseq ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Github : https://github.com/nf-core/chipseq -Website: https://nf-co.re/chipseq + Website: https://nf-co.re/chipseq Slack : https://nfcore.slack.com/channels/chipseq ---------------------------------------------------------------------------------------- */ From 1d469ce5dc389c28f095b1bbbae7e096f26e5aa5 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Mon, 12 Sep 2022 15:04:55 +0100 Subject: [PATCH 509/538] Remove new lines --- nextflow.config | 3 --- 1 file changed, 3 deletions(-) diff --git a/nextflow.config b/nextflow.config index c2e329b6f..801b0c2f6 100644 --- a/nextflow.config +++ b/nextflow.config @@ -15,7 +15,6 @@ params { fingerprint_bins = 500000 read_length = null - // References genome = null igenomes_base = 's3://ngi-igenomes/igenomes' @@ -88,7 +87,6 @@ params { schema_ignore_params = 'genomes' enable_conda = false - // Config options custom_config_version = 'master' custom_config_base = "https://raw.githubusercontent.com/nf-core/configs/${params.custom_config_version}" @@ -97,7 +95,6 @@ params { config_profile_url = null config_profile_name = null - // Max resource options // Defaults only, expecting to be overwritten max_memory = '128.GB' From c1b8bc8af775a517226257d4da40ba1ebb4b49a9 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Mon, 12 Sep 2022 15:07:51 +0100 Subject: [PATCH 510/538] Fix channels for GUNZIP processes --- subworkflows/local/prepare_genome.nf | 10 +++++----- 1 file changed, 5 insertions(+), 5 deletions(-) diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index 9c8615993..3e90cff5b 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -38,7 +38,7 @@ workflow PREPARE_GENOME { // ch_fasta = Channel.empty() if (params.fasta.endsWith('.gz')) { - ch_fasta = GUNZIP_FASTA ( [:], params.fasta ).gunzip.map{ it[1] } + ch_fasta = GUNZIP_FASTA ( [ [:], params.fasta ] ).gunzip.map{ it[1] } ch_versions = ch_versions.mix(GUNZIP_FASTA.out.versions) } else { ch_fasta = file(params.fasta) @@ -55,14 +55,14 @@ workflow PREPARE_GENOME { // if (params.gtf) { if (params.gtf.endsWith('.gz')) { - ch_gtf = GUNZIP_GTF ( [:], params.gtf ).gunzip.map{ it[1] } + ch_gtf = GUNZIP_GTF ( [ [:], params.gtf ] ).gunzip.map{ it[1] } ch_versions = ch_versions.mix(GUNZIP_GTF.out.versions) } else { ch_gtf = file(params.gtf) } } else if (params.gff) { if (params.gff.endsWith('.gz')) { - ch_gff = GUNZIP_GFF ( [:], params.gff ).gunzip.map{ it[1] } + ch_gff = GUNZIP_GFF ( [ [:], params.gff ] ).gunzip.map{ it[1] } ch_versions = ch_versions.mix(GUNZIP_GFF.out.versions) } else { ch_gff = file(params.gff) @@ -77,7 +77,7 @@ workflow PREPARE_GENOME { ch_blacklist = Channel.empty() if (params.blacklist) { if (params.blacklist.endsWith('.gz')) { - ch_blacklist = GUNZIP_BLACKLIST ( [:], params.blacklist ).gunzip.map{ it[1] } + ch_blacklist = GUNZIP_BLACKLIST ( [ [:], params.blacklist ] ).gunzip.map{ it[1] } ch_versions = ch_versions.mix(GUNZIP_BLACKLIST.out.versions) } else { ch_blacklist = Channel.fromPath(file(params.blacklist)) @@ -104,7 +104,7 @@ workflow PREPARE_GENOME { ch_versions = ch_versions.mix(GTF2BED.out.versions) } else { if (params.gene_bed.endsWith('.gz')) { - ch_gene_bed = GUNZIP_GENE_BED ( [:], params.gene_bed ).gunzip.map{ it[1] } + ch_gene_bed = GUNZIP_GENE_BED ( [ [:], params.gene_bed ] ).gunzip.map{ it[1] } ch_versions = ch_versions.mix(GUNZIP_GENE_BED.out.versions) } else { ch_gene_bed = file(params.gene_bed) From 9204c7d1e404bf5abf5dca7a8bd1c4750c9754d9 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Mon, 12 Sep 2022 15:09:33 +0100 Subject: [PATCH 511/538] Fix channels for UNTAR processes --- subworkflows/local/prepare_genome.nf | 8 ++++---- 1 file changed, 4 insertions(+), 4 deletions(-) diff --git a/subworkflows/local/prepare_genome.nf b/subworkflows/local/prepare_genome.nf index 3e90cff5b..9b6422c6a 100644 --- a/subworkflows/local/prepare_genome.nf +++ b/subworkflows/local/prepare_genome.nf @@ -137,7 +137,7 @@ workflow PREPARE_GENOME { if (prepare_tool_index == 'bwa') { if (params.bwa_index) { if (params.bwa_index.endsWith('.tar.gz')) { - ch_bwa_index = UNTAR_BWA_INDEX ( [:], params.bwa_index ).untar.map{ it[1] } + ch_bwa_index = UNTAR_BWA_INDEX ( [ [:], params.bwa_index ] ).untar.map{ it[1] } ch_versions = ch_versions.mix(UNTAR_BWA_INDEX.out.versions) } else { ch_bwa_index = file(params.bwa_index) @@ -155,7 +155,7 @@ workflow PREPARE_GENOME { if (prepare_tool_index == 'bowtie2') { if (params.bowtie2_index) { if (params.bowtie2_index.endsWith('.tar.gz')) { - ch_bowtie2_index = UNTAR_BOWTIE2_INDEX ( [:], params.bowtie2_index ).untar.map{ it[1] } + ch_bowtie2_index = UNTAR_BOWTIE2_INDEX ( [ [:], params.bowtie2_index ] ).untar.map{ it[1] } ch_versions = ch_versions.mix(UNTAR_BOWTIE2_INDEX.out.versions) } else { ch_bowtie2_index = file(params.bowtie2_index) @@ -173,7 +173,7 @@ workflow PREPARE_GENOME { if (prepare_tool_index == 'chromap') { if (params.chromap_index) { if (params.chromap_index.endsWith('.tar.gz')) { - ch_chromap_index = UNTAR_CHROMAP_INDEX ( [:], params.chromap_index ).untar.map{ it[1] } + ch_chromap_index = UNTAR_CHROMAP_INDEX ( [ [:], params.chromap_index ] ).untar.map{ it[1] } ch_versions = ch_versions.mix(UNTAR.out.versions) } else { ch_chromap_index = file(params.chromap_index) @@ -191,7 +191,7 @@ workflow PREPARE_GENOME { if (prepare_tool_index == 'star') { if (params.star_index) { if (params.star_index.endsWith('.tar.gz')) { - ch_star_index = UNTAR_STAR_INDEX ( [:], params.star_index ).untar.map{ it[1] } + ch_star_index = UNTAR_STAR_INDEX ( [ [:], params.star_index ] ).untar.map{ it[1] } ch_versions = ch_versions.mix(UNTAR_STAR_INDEX.out.versions) } else { ch_star_index = file(params.star_index) From 7b444219f9d74f950139c07a9ecbb7a14575e5e4 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Wed, 14 Sep 2022 14:45:34 +0100 Subject: [PATCH 512/538] Fix or reword bits in the pipeline --- conf/modules.config | 23 +++++++++++++++-------- conf/test.config | 8 ++++---- conf/test_full.config | 2 +- lib/WorkflowChipseq.groovy | 4 ++-- 4 files changed, 22 insertions(+), 15 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 47784e03d..729c7734e 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -396,7 +396,6 @@ process { withName: 'PHANTOMPEAKQUALTOOLS' { ext.args2 = { "-p=$task.cpus" } - ext.prefix = { "${meta.id}.mLb.clN" } publishDir = [ path: { "${params.outdir}/${params.aligner}/mergedLibrary/phantompeakqualtools" }, mode: params.publish_dir_mode, @@ -599,7 +598,8 @@ if (!params.skip_peak_annotation) { } withName: 'PLOT_HOMER_ANNOTATEPEAKS' { - ext.args = '-o ./ -p macs2_annotatePeaks' + ext.args = '-o ./' + ext.prefix = 'macs2_annotatePeaks' publishDir = [ path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", @@ -623,7 +623,8 @@ if (!params.skip_consensus_peaks) { path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus' + '/consensus', + "/${meta.id}" ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } @@ -632,11 +633,13 @@ if (!params.skip_consensus_peaks) { withName: 'SUBREAD_FEATURECOUNTS' { ext.args = '-F SAF -O --fracOverlap 0.2' + ext.prefix = { "${meta.id}.consensus_peaks" } publishDir = [ path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus' + '/consensus', + "/${meta.id}" ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } @@ -648,24 +651,27 @@ if (!params.skip_consensus_peaks) { process { withName: 'HOMER_ANNOTATEPEAKS_CONSENSUS' { ext.args = '-gid' - ext.prefix = 'consensus_peaks' + ext.prefix = { "${meta.id}.consensus_peaks" } publishDir = [ path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus' + '/consensus', + "/${meta.id}" ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } ] } + withName: 'ANNOTATE_BOOLEAN_PEAKS' { - ext.prefix = { "${meta.id}_peaks" } + ext.prefix = { "${meta.id}.consensus_peaks" } publishDir = [ path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus' + '/consensus', + "/${meta.id}" ].join('') }, mode: params.publish_dir_mode, saveAs: { filename -> filename.equals('versions.yml') ? null : filename } @@ -689,6 +695,7 @@ if (!params.skip_consensus_peaks) { "${params.outdir}/${params.aligner}/mergedLibrary/macs2", params.narrow_peak? '/narrowPeak' : '/broadPeak', '/consensus', + "/${meta.id}", '/deseq2' ].join('') }, mode: params.publish_dir_mode, diff --git a/conf/test.config b/conf/test.config index 2fad3bc87..9b24bc9af 100644 --- a/conf/test.config +++ b/conf/test.config @@ -11,13 +11,13 @@ */ params { - config_profile_name = 'Test profile' + config_profile_name = 'Test profile' config_profile_description = 'Minimal test dataset to check pipeline function' // Limit resources so that this can run on GitHub Actions - max_cpus = 2 - max_memory = 6.GB - max_time = 6.h + max_cpus = 2 + max_memory = '6.GB' + max_time = '6.h' // Input data input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/samplesheet/v2.0/samplesheet_test.csv' diff --git a/conf/test_full.config b/conf/test_full.config index f47445a54..d25c37d79 100644 --- a/conf/test_full.config +++ b/conf/test_full.config @@ -17,7 +17,7 @@ params { // Input data for full size test input = 'https://raw.githubusercontent.com/nf-core/test-datasets/chipseq/samplesheet/v2.0/samplesheet_full.csv' - // Used to get macs_gsize + // Used to calculate --macs_gsize read_length = 50 // Genome references diff --git a/lib/WorkflowChipseq.groovy b/lib/WorkflowChipseq.groovy index b46f9362b..dfae806fc 100755 --- a/lib/WorkflowChipseq.groovy +++ b/lib/WorkflowChipseq.groovy @@ -12,7 +12,7 @@ class WorkflowChipseq { if (!params.fasta) { - log.error "Genome fasta file not specified with e.g. '--fasta genome.fa' or via a detectable config file." + log.error "Genome fasta file not specified with e.g. '--fasta' or via a detectable config file." System.exit(1) } @@ -98,7 +98,7 @@ class WorkflowChipseq { log.warn "=============================================================================\n" + " --macs_gsize parameter has not been provided.\n" + " It will be auto-calculated by 'khmer unique-kmers.py' using the '--read_length' parameter.\n" + - " Explicitly provide '--macs_gsize macs2_genome_size' to change this behaviour.\n" + + " Explicitly provide '--macs_gsize' to change this behaviour.\n" + "===================================================================================" } From 377489fda2d6ff12f8ef6c46cad34b1e879b4e84 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Wed, 14 Sep 2022 14:45:54 +0100 Subject: [PATCH 513/538] Add prefix to homer module --- modules/local/plot_homer_annotatepeaks.nf | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/modules/local/plot_homer_annotatepeaks.nf b/modules/local/plot_homer_annotatepeaks.nf index 2cb38a373..11ed3daba 100644 --- a/modules/local/plot_homer_annotatepeaks.nf +++ b/modules/local/plot_homer_annotatepeaks.nf @@ -19,13 +19,15 @@ process PLOT_HOMER_ANNOTATEPEAKS { script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ def args = task.ext.args ?: '' + def prefix = task.ext.prefix ?: "annotatepeaks" """ plot_homer_annotatepeaks.r \\ -i ${annos.join(',')} \\ -s ${annos.join(',').replaceAll("${suffix}","")} \\ + -p $prefix \\ $args - find ./ -type f -name "*.txt" -exec cat {} \\; | cat $mqc_header - > annotatepeaks.summary_mqc.tsv + find ./ -type f -name "*.txt" -exec cat {} \\; | cat $mqc_header - > ${prefix}.summary_mqc.tsv cat <<-END_VERSIONS > versions.yml "${task.process}": From ea942635985e3dbe5d9273e137fb175d333e59cd Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Wed, 14 Sep 2022 16:54:39 +0100 Subject: [PATCH 514/538] Fix missing tools in MultiQC report --- assets/multiqc_config.yml | 2 +- modules/local/multiqc.nf | 5 +++-- workflows/chipseq.nf | 16 +++++++++------- 3 files changed, 13 insertions(+), 10 deletions(-) diff --git a/assets/multiqc_config.yml b/assets/multiqc_config.yml index 1a55a16cb..4493905e5 100644 --- a/assets/multiqc_config.yml +++ b/assets/multiqc_config.yml @@ -72,7 +72,7 @@ module_order: anchor: "mlib_featurecounts" info: "This section of the report shows featureCounts results for the number of reads assigned to merged library consensus peaks." path_filters: - - "./macs/consensus/*.summary" + - "./macs2/featurecounts/*.summary" report_section_order: peak_count: diff --git a/modules/local/multiqc.nf b/modules/local/multiqc.nf index 92824f01d..702b239f4 100644 --- a/modules/local/multiqc.nf +++ b/modules/local/multiqc.nf @@ -31,8 +31,10 @@ process MULTIQC { path ('alignment/mergedLibrary/filtered/picard_metrics/*') path ('preseq/*') + path ('deeptools/*') path ('deeptools/*') + path ('phantompeakqualtools/*') path ('phantompeakqualtools/*') path ('phantompeakqualtools/*') @@ -41,8 +43,7 @@ process MULTIQC { path ('macs2/peaks/*') path ('macs2/peaks/*') path ('macs2/annotation/*') - - path ('featurecounts/*') + path ('macs2/featurecounts/*') path ('deseq2/*') path ('deseq2/*') diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index eedccc5d5..387ed32a7 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -228,9 +228,9 @@ workflow CHIPSEQ { def count = it.size() if (count > 0) { log.warn "=============================================================================\n" + - " Paired-end files produced by chromap can not be used by some downstream tools due the issue below:\n" + + " Paired-end files produced by chromap cannot be used by some downstream tools due to the issue below:\n" + " https://github.com/nf-core/chipseq/issues/291\n" + - " They will be excluded from the analysis. Consider to use a different aligner\n" + + " They will be excluded from the analysis. Consider using a different aligner\n" + "===================================================================================" } } @@ -268,7 +268,8 @@ workflow CHIPSEQ { ch_genome_bam .map { meta, bam -> - def fmeta = meta.findAll { it.key != 'read_group' } + def fmeta = meta.clone() + fmeta.remove('read_group') fmeta.id = fmeta.id.split('_')[0..-2].join('_') [ fmeta, bam ] } .groupTuple(by: [0]) @@ -294,7 +295,6 @@ workflow CHIPSEQ { FILTER_BAM_BAMTOOLS ( MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), PREPARE_GENOME.out.filtered_bed.first(), - ch_bamtools_filter_se_config, ch_bamtools_filter_pe_config ) @@ -414,7 +414,7 @@ workflow CHIPSEQ { DEEPTOOLS_PLOTFINGERPRINT ( ch_ip_control_bam_bai ) - ch_deeptools_plotfingerprintmultiqc = DEEPTOOLS_PLOTFINGERPRINT.out.matrix + ch_deeptoolsplotfingerprint_multiqc = DEEPTOOLS_PLOTFINGERPRINT.out.matrix ch_versions = ch_versions.mix(DEEPTOOLS_PLOTFINGERPRINT.out.versions.first()) } @@ -426,7 +426,6 @@ workflow CHIPSEQ { ch_custompeaks_count_multiqc = Channel.empty() ch_plothomerannotatepeaks_multiqc = Channel.empty() ch_subreadfeaturecounts_multiqc = Channel.empty() - ch_macs_gsize = params.macs_gsize if (!params.macs_gsize) { KHMER_UNIQUEKMERS ( @@ -649,8 +648,10 @@ workflow CHIPSEQ { ch_picardcollectmultiplemetrics_multiqc.collect{it[1]}.ifEmpty([]), ch_preseq_multiqc.collect{it[1]}.ifEmpty([]), + ch_deeptoolsplotprofile_multiqc.collect{it[1]}.ifEmpty([]), ch_deeptoolsplotfingerprint_multiqc.collect{it[1]}.ifEmpty([]), + PHANTOMPEAKQUALTOOLS.out.spp.collect{it[1]}.ifEmpty([]), MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.nsc.collect{it[1]}.ifEmpty([]), MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS.out.rsc.collect{it[1]}.ifEmpty([]), @@ -660,10 +661,11 @@ workflow CHIPSEQ { ch_custompeaks_count_multiqc.collect{it[1]}.ifEmpty([]), ch_plothomerannotatepeaks_multiqc.collect().ifEmpty([]), ch_subreadfeaturecounts_multiqc.collect{it[1]}.ifEmpty([]), + ch_deseq2_pca_multiqc.collect().ifEmpty([]), ch_deseq2_clustering_multiqc.collect().ifEmpty([]) ) - multiqc_report = MULTIQC.out.report.toList() + multiqc_report = MULTIQC.out.report.toList() } } From bd1dd009bc3ca3e2881a3080a4cfac47d820f87e Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Wed, 14 Sep 2022 17:14:18 +0100 Subject: [PATCH 515/538] Print versions for correct process --- workflows/chipseq.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 387ed32a7..698f97e1f 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -373,7 +373,7 @@ workflow CHIPSEQ { DEEPTOOLS_COMPUTEMATRIX.out.matrix ) ch_deeptoolsplotprofile_multiqc = DEEPTOOLS_PLOTPROFILE.out.table - ch_versions = ch_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first()) + ch_versions = ch_versions.mix(DEEPTOOLS_PLOTPROFILE.out.versions.first()) DEEPTOOLS_PLOTHEATMAP ( DEEPTOOLS_COMPUTEMATRIX.out.matrix From ef3637bad4bff71fbec8a20c234444ceccb23b83 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Wed, 14 Sep 2022 20:22:12 +0100 Subject: [PATCH 516/538] Fix FRiP score being printed twice to file --- modules/local/frip_score.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/modules/local/frip_score.nf b/modules/local/frip_score.nf index e8fdbcc91..337b18c53 100644 --- a/modules/local/frip_score.nf +++ b/modules/local/frip_score.nf @@ -20,7 +20,7 @@ process FRIP_SCORE { """ READS_IN_PEAKS=\$(intersectBed -a $bam -b $peak $args | awk -F '\t' '{sum += \$NF} END {print sum}') samtools flagstat $bam > ${bam}.flagstat - grep 'mapped (' ${bam}.flagstat | awk -v a="\$READS_IN_PEAKS" -v OFS='\t' '{print "${prefix}", a/\$1}' > ${prefix}.FRiP.txt + grep 'mapped (' ${bam}.flagstat | grep -v "primary" | awk -v a="\$READS_IN_PEAKS" -v OFS='\t' '{print "${prefix}", a/\$1}' > ${prefix}.FRiP.txt cat <<-END_VERSIONS > versions.yml "${task.process}": From f518dd8dd240eec8d48908d616360b462c7feaf2 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Thu, 15 Sep 2022 11:32:43 +0100 Subject: [PATCH 517/538] Re-factor channel joining for ip and control --- workflows/chipseq.nf | 34 +++++++++++++--------------------- 1 file changed, 13 insertions(+), 21 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 698f97e1f..3ed9eb118 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -268,10 +268,10 @@ workflow CHIPSEQ { ch_genome_bam .map { meta, bam -> - def fmeta = meta.clone() - fmeta.remove('read_group') - fmeta.id = fmeta.id.split('_')[0..-2].join('_') - [ fmeta, bam ] } + def meta_clone = meta.clone() + meta_clone.remove('read_group') + meta_clone.id = meta_clone.id.split('_')[0..-2].join('_') + [ meta_clone, bam ] } .groupTuple(by: [0]) .map { it -> [ it[0], it[1].flatten() ] } .set { ch_sort_bam } @@ -387,25 +387,17 @@ workflow CHIPSEQ { FILTER_BAM_BAMTOOLS .out .bam - .join (FILTER_BAM_BAMTOOLS.out.bai, by: [0]) - .map { - meta, bam, bai -> - meta.control ? null : [ meta.id, [ bam ] , [ bai ] ] - } - .set { ch_control_bam_bai } - - FILTER_BAM_BAMTOOLS - .out - .bam - .join (FILTER_BAM_BAMTOOLS.out.bai, by: [0]) - .map { - meta, bam, bai -> - meta.control ? [ meta.control, meta, [ bam ], [ bai ] ] : null + .join(FILTER_BAM_BAMTOOLS.out.bai, by: [0]) + .set { ch_genome_bam_bai } + + ch_genome_bam_bai + .combine(ch_genome_bam_bai) + .map { + meta1, bam1, bai1, meta2, bam2, bai2 -> + meta1.control == meta2.id ? [ meta1, [ bam1, bam2 ], [ bai1, bai2 ] ] : null } - .combine(ch_control_bam_bai, by: 0) - .map { it -> [ it[1] , it[2] + it[4], it[3] + it[5] ] } .set { ch_ip_control_bam_bai } - + // // plotFingerprint for IP and control together // From 6f17b333af13937fe00800706b240b2e3f20a810 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Thu, 15 Sep 2022 11:47:54 +0100 Subject: [PATCH 518/538] Add meta.id tag where missing to local modules --- modules/local/annotate_boolean_peaks.nf | 2 +- modules/local/multiqc_custom_peaks.nf | 2 +- modules/local/multiqc_custom_phantompeakqualtools.nf | 1 + 3 files changed, 3 insertions(+), 2 deletions(-) diff --git a/modules/local/annotate_boolean_peaks.nf b/modules/local/annotate_boolean_peaks.nf index 8d45fe92f..ab2dfbed3 100644 --- a/modules/local/annotate_boolean_peaks.nf +++ b/modules/local/annotate_boolean_peaks.nf @@ -1,5 +1,5 @@ process ANNOTATE_BOOLEAN_PEAKS { - + tag "$meta.id" label 'process_low' conda (params.enable_conda ? "conda-forge::sed=4.7" : null) diff --git a/modules/local/multiqc_custom_peaks.nf b/modules/local/multiqc_custom_peaks.nf index 1ca41d4ce..ebef7b13a 100644 --- a/modules/local/multiqc_custom_peaks.nf +++ b/modules/local/multiqc_custom_peaks.nf @@ -1,5 +1,5 @@ process MULTIQC_CUSTOM_PEAKS { - + tag "$meta.id" conda (params.enable_conda ? "conda-forge::sed=4.7" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? 'https://depot.galaxyproject.org/singularity/ubuntu:20.04' : diff --git a/modules/local/multiqc_custom_phantompeakqualtools.nf b/modules/local/multiqc_custom_phantompeakqualtools.nf index 706af4fc0..4878e2c27 100644 --- a/modules/local/multiqc_custom_phantompeakqualtools.nf +++ b/modules/local/multiqc_custom_phantompeakqualtools.nf @@ -1,4 +1,5 @@ process MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS { + tag "$meta.id" conda (params.enable_conda ? "conda-forge::r-base=3.5.1" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? 'https://depot.galaxyproject.org/singularity/r-base:3.5.1': From 474e226ff821617b8bb0a505ac6ec7a16bb9f130 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Thu, 15 Sep 2022 13:01:07 +0100 Subject: [PATCH 519/538] Re-factor channel joining for featurecounts --- workflows/chipseq.nf | 142 ++++++++++++++++++++++++++----------------- 1 file changed, 87 insertions(+), 55 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 3ed9eb118..9a06c666c 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -224,15 +224,16 @@ workflow CHIPSEQ { ch_genome_bam_chromap.paired_end .collect() - .map { it -> - def count = it.size() - if (count > 0) { - log.warn "=============================================================================\n" + - " Paired-end files produced by chromap cannot be used by some downstream tools due to the issue below:\n" + - " https://github.com/nf-core/chipseq/issues/291\n" + - " They will be excluded from the analysis. Consider using a different aligner\n" + - "===================================================================================" - } + .map { + it -> + def count = it.size() + if (count > 0) { + log.warn "=============================================================================\n" + + " Paired-end files produced by chromap cannot be used by some downstream tools due to the issue below:\n" + + " https://github.com/nf-core/chipseq/issues/291\n" + + " They will be excluded from the analysis. Consider using a different aligner\n" + + "===================================================================================" + } } ch_genome_bam = ch_genome_bam_chromap.single_end @@ -271,9 +272,13 @@ workflow CHIPSEQ { def meta_clone = meta.clone() meta_clone.remove('read_group') meta_clone.id = meta_clone.id.split('_')[0..-2].join('_') - [ meta_clone, bam ] } + [ meta_clone, bam ] + } .groupTuple(by: [0]) - .map { it -> [ it[0], it[1].flatten() ] } + .map { + it -> + [ it[0], it[1].flatten() ] + } .set { ch_sort_bam } PICARD_MERGESAMFILES ( @@ -309,7 +314,7 @@ workflow CHIPSEQ { MARK_DUPLICATES_PICARD.out.bam ) ch_preseq_multiqc = PRESEQ_LCEXTRAP.out.lc_extrap - ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions.first()) + ch_versions = ch_versions.mix(PRESEQ_LCEXTRAP.out.versions.first()) } // @@ -382,7 +387,7 @@ workflow CHIPSEQ { } // - // Refactor channels: [ val(meta), [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] + // Refactor channels: [ meta, [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] // FILTER_BAM_BAMTOOLS .out @@ -427,9 +432,12 @@ workflow CHIPSEQ { ch_macs_gsize = KHMER_UNIQUEKMERS.out.kmers.map { it.text.trim() } } - // Create channel: [ val(meta), ip_bam, control_bam ] + // Create channel: [ meta, ip_bam, control_bam ] ch_ip_control_bam_bai - .map { meta, bams, bais -> [ meta , bams[0], bams[1] ] } + .map { + meta, bams, bais -> + [ meta , bams[0], bams[1] ] + } .set { ch_ip_control_bam } MACS2_CALLPEAK ( @@ -447,23 +455,31 @@ workflow CHIPSEQ { .filter { meta, peaks -> peaks.size() > 0 } .set { ch_macs2_peaks } + // Create channel: [ meta, ip_bam, peaks ] ch_ip_control_bam .join(ch_macs2_peaks, by: [0]) - .map { it -> [ it[0], it[1], it[3] ] } - .set { ch_ip_peak } + .map { + it -> + [ it[0], it[1], it[3] ] + } + .set { ch_ip_bam_peaks } FRIP_SCORE ( - ch_ip_peak + ch_ip_bam_peaks ) ch_versions = ch_versions.mix(FRIP_SCORE.out.versions.first()) - ch_ip_peak + // Create channel: [ meta, peaks, frip ] + ch_ip_bam_peaks .join(FRIP_SCORE.out.txt, by: [0]) - .map { it -> [ it[0], it[2], it[3] ] } - .set { ch_ip_peak_frip } + .map { + it -> + [ it[0], it[2], it[3] ] + } + .set { ch_ip_peaks_frip } MULTIQC_CUSTOM_PEAKS ( - ch_ip_peak_frip, + ch_ip_peaks_frip, ch_peak_count_header, ch_frip_score_header ) @@ -502,9 +518,12 @@ workflow CHIPSEQ { ch_deseq2_clustering_multiqc = Channel.empty() if (!params.skip_consensus_peaks) { // Create channel: [ meta , [ peaks ] ] - // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] + // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] ch_macs2_peaks - .map { meta, peak -> [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] } + .map { + meta, peak -> + [ meta.antibody, meta.id.split('_')[0..-2].join('_'), peak ] + } .groupTuple() .map { antibody, groups, peaks -> @@ -512,21 +531,23 @@ workflow CHIPSEQ { antibody, groups.groupBy().collectEntries { [(it.key) : it.value.size()] }, peaks - ] } + ] + } .map { antibody, groups, peaks -> - def meta = [:] - meta.id = antibody - meta.multiple_groups = groups.size() > 1 - meta.replicates_exist = groups.max { groups.value }.value > 1 - [ meta, peaks ] } + def meta_new = [:] + meta_new.id = antibody + meta_new.multiple_groups = groups.size() > 1 + meta_new.replicates_exist = groups.max { groups.value }.value > 1 + [ meta_new, peaks ] + } .set { ch_antibody_peaks } MACS2_CONSENSUS ( ch_antibody_peaks ) ch_macs2_consensus_bed_lib = MACS2_CONSENSUS.out.bed - ch_versions = ch_versions.mix(MACS2_CONSENSUS.out.versions) + ch_versions = ch_versions.mix(MACS2_CONSENSUS.out.versions) if (!params.skip_peak_annotation) { HOMER_ANNOTATEPEAKS_CONSENSUS ( @@ -542,29 +563,32 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(ANNOTATE_BOOLEAN_PEAKS.out.versions) } - // Create channel: [ val(meta), ip_bam ] + // Create channel: [ antibody, [ ip_bams ] ] + ch_ip_control_bam + .map { + meta, ip_bam, control_bam -> + [ meta.antibody, ip_bam ] + } + .groupTuple() + .set { ch_antibody_bams } + + // Create channel: [ meta, [ ip_bams ], saf ] MACS2_CONSENSUS .out .saf - .map { meta, saf -> [ meta.id, meta, saf ] } - .set { ch_ip_saf } - - ch_ip_control_bam - .map { meta, ip_bam, control_bam -> [ meta.antibody, meta, ip_bam ] } - .groupTuple() - .map { it -> [ it[0], it[1][0], it[2].flatten().sort() ] } - .join(ch_ip_saf) + .map { + meta, saf -> + [ meta.id, meta, saf ] + } + .join(ch_antibody_bams) .map { - it -> - def fmeta = it[1] - fmeta['id'] = it[3]['id'] - fmeta['replicates_exist'] = it[3]['replicates_exist'] - fmeta['multiple_groups'] = it[3]['multiple_groups'] - [ fmeta, it[2], it[4] ] } - .set { ch_ip_bam } + antibody, meta, saf, bams -> + [ meta, bams.flatten().sort(), saf ] + } + .set { ch_saf_bams } SUBREAD_FEATURECOUNTS ( - ch_ip_bam + ch_saf_bams ) ch_subreadfeaturecounts_multiqc = SUBREAD_FEATURECOUNTS.out.summary ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first()) @@ -590,13 +614,21 @@ workflow CHIPSEQ { ch_macs2_peaks.collect{it[1]}.ifEmpty([]), ch_macs2_consensus_bed_lib.collect{it[1]}.ifEmpty([]), { "${params.aligner}/mergedLibrary/bigwig" }, - { ["${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak' - ].join('') }, - { ["${params.aligner}/mergedLibrary/macs2", - params.narrow_peak? '/narrowPeak' : '/broadPeak', - '/consensus' - ].join('') } + { + [ + "${params.aligner}/mergedLibrary/macs2", + params.narrow_peak ? '/narrowPeak' : '/broadPeak' + ] + .join('') + }, + { + [ + "${params.aligner}/mergedLibrary/macs2", + params.narrow_peak ? '/narrowPeak' : '/broadPeak', + '/consensus' + ] + .join('') + } ) ch_versions = ch_versions.mix(IGV.out.versions) } From 3e1857d103aaef72f22a2e1cfbc62cb90b225e46 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Thu, 15 Sep 2022 13:01:31 +0100 Subject: [PATCH 520/538] Remove antibody variable reference in DESeq2 module --- conf/modules.config | 1 + modules/local/deseq2_qc.nf | 7 +++---- 2 files changed, 4 insertions(+), 4 deletions(-) diff --git a/conf/modules.config b/conf/modules.config index 729c7734e..b46fec836 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -690,6 +690,7 @@ if (!params.skip_consensus_peaks) { '--count_col 7', params.deseq2_vst ? '--vst TRUE' : '' ].join(' ').trim() + ext.prefix = { "${meta.id}.consensus_peaks" } publishDir = [ path: { [ "${params.outdir}/${params.aligner}/mergedLibrary/macs2", diff --git a/modules/local/deseq2_qc.nf b/modules/local/deseq2_qc.nf index bdf5535af..7fc5a9f2a 100644 --- a/modules/local/deseq2_qc.nf +++ b/modules/local/deseq2_qc.nf @@ -27,8 +27,7 @@ process DESEQ2_QC { script: def args = task.ext.args ?: '' def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' - def antibody = meta.antibody - def prefix = "${antibody}.consensus_peaks" + def prefix = task.ext.prefix ?: "${meta.id}" """ deseq2_qc.r \\ --count_file $counts \\ @@ -38,11 +37,11 @@ process DESEQ2_QC { $args sed 's/deseq2_pca/deseq2_pca_${task.index}/g' <$deseq2_pca_header >tmp.txt - sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt + sed -i -e 's/DESeq2 /${meta.id} DESeq2 /g' tmp.txt cat tmp.txt ${prefix}.pca.vals.txt > ${prefix}.pca.vals_mqc.tsv sed 's/deseq2_clustering/deseq2_clustering_${task.index}/g' <$deseq2_clustering_header >tmp.txt - sed -i -e 's/DESeq2 /${antibody} DESeq2 /g' tmp.txt + sed -i -e 's/DESeq2 /${meta.id} DESeq2 /g' tmp.txt cat tmp.txt ${prefix}.sample.dists.txt > ${prefix}.sample.dists_mqc.tsv cat <<-END_VERSIONS > versions.yml From d984c095fab3c7cdbf64585ab812652917f0a570 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Thu, 15 Sep 2022 13:04:11 +0100 Subject: [PATCH 521/538] Switch deseq2_vst to true by default --- docs/output.md | 2 +- nextflow.config | 2 +- nextflow_schema.json | 31 ++++++++++++++++++++++++++----- 3 files changed, 28 insertions(+), 7 deletions(-) diff --git a/docs/output.md b/docs/output.md index 6fde66dec..9dd852ebb 100644 --- a/docs/output.md +++ b/docs/output.md @@ -261,7 +261,7 @@ The [featureCounts](http://bioinf.wehi.edu.au/featureCounts/) tool is used to co **This pipeline uses a standardised DESeq2 analysis script to get an idea of the reproducibility within the experiment, and to assess the overall differential binding. Please note that this will not suit every experimental design, and if there are other problems with the experiment then it may not work as well as expected.** -For larger experiments, it may be recommended to use the `vst` transformation instead of the default `rlog` option. You can do this by providing the `--deseq2_vst` parameter to the pipeline. See [DESeq2 docs](http://bioconductor.org/packages/devel/bioc/vignettes/DESeq2/inst/doc/DESeq2.html#data-transformations-and-visualization) for a more detailed explanation. +For larger experiments, it is recommended to use the `vst` transformation instead of the default `rlog` option. This is the default behaviour and can be controlled with the `--deseq2_vst` parameter. See [DESeq2 docs](http://bioconductor.org/packages/devel/bioc/vignettes/DESeq2/inst/doc/DESeq2.html#data-transformations-and-visualization) for a more detailed explanation. ![MultiQC - DESeq2 PCA plot](images/mqc_deseq2_pca_plot.png) diff --git a/nextflow.config b/nextflow.config index 801b0c2f6..e7c2b71d1 100644 --- a/nextflow.config +++ b/nextflow.config @@ -50,7 +50,7 @@ params { skip_consensus_peaks = false // Options: DESeq2 QC - deseq2_vst = false + deseq2_vst = true skip_deseq2_qc = false // Options: QC diff --git a/nextflow_schema.json b/nextflow_schema.json index ea0721e1b..839dc19e8 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -10,7 +10,9 @@ "type": "object", "fa_icon": "fas fa-terminal", "description": "Define where the pipeline should find input data and save output data.", - "required": ["outdir"], + "required": [ + "outdir" + ], "properties": { "input": { "type": "string", @@ -37,7 +39,13 @@ "type": "integer", "description": "Read length used to calculate MACS2 genome size for peak calling if `--macs_gsize` isn't provided.", "fa_icon": "fas fa-chart-area", - "enum": [50, 75, 100, 150, 200] + "enum": [ + 50, + 75, + 100, + 150, + 200 + ] }, "outdir": { "type": "string", @@ -221,7 +229,12 @@ "default": "bwa", "description": "Specifies the alignment algorithm to use - available options are 'bwa', 'bowtie2' and 'star'.", "fa_icon": "fas fa-map-signs", - "enum": ["bwa", "bowtie2", "chromap", "star"] + "enum": [ + "bwa", + "bowtie2", + "chromap", + "star" + ] }, "keep_dups": { "type": "boolean", @@ -348,7 +361,8 @@ "type": "boolean", "description": "Use vst transformation instead of rlog with DESeq2.", "help_text": "See [DESeq2 docs](http://bioconductor.org/packages/devel/bioc/vignettes/DESeq2/inst/doc/DESeq2.html#data-transformations-and-visualization).", - "fa_icon": "fas fa-dolly" + "fa_icon": "fas fa-dolly", + "default": true }, "skip_plot_profile": { "type": "boolean", @@ -489,7 +503,14 @@ "description": "Method used to save pipeline results to output directory.", "help_text": "The Nextflow `publishDir` option specifies which intermediate files should be saved to the output directory. This option tells the pipeline what method should be used to move these files. See [Nextflow docs](https://www.nextflow.io/docs/latest/process.html#publishdir) for details.", "fa_icon": "fas fa-copy", - "enum": ["symlink", "rellink", "link", "copy", "copyNoFollow", "move"], + "enum": [ + "symlink", + "rellink", + "link", + "copy", + "copyNoFollow", + "move" + ], "hidden": true }, "fingerprint_bins": { From 3ea01409813f555735106fe73eca778cc15d9743 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Thu, 15 Sep 2022 13:27:16 +0100 Subject: [PATCH 522/538] Add missing header comments to all modules/subworkflows --- workflows/chipseq.nf | 94 ++++++++++++++++++++++++++++++++------------ 1 file changed, 69 insertions(+), 25 deletions(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 9a06c666c..01ec3eb90 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -182,7 +182,7 @@ workflow CHIPSEQ { } // - // SUBWORKFLOW: Alignment with BOWTIE2 & BAM QC + // SUBWORKFLOW: Alignment with Bowtie2 & BAM QC // if (params.aligner == 'bowtie2') { ALIGN_BOWTIE2 ( @@ -199,7 +199,7 @@ workflow CHIPSEQ { } // - // SUBWORKFLOW: Alignment with CHROMAP & BAM QC + // SUBWORKFLOW: Alignment with Chromap & BAM QC // if (params.aligner == 'chromap') { ALIGN_CHROMAP ( @@ -210,7 +210,7 @@ workflow CHIPSEQ { // Filter out paired-end reads until the issue below is fixed // https://github.com/nf-core/chipseq/issues/291 - // ch_genome_bam = ALIGN_CHROMAP.out.bam + // ch_genome_bam = ALIGN_CHROMAP.out.bam ALIGN_CHROMAP .out .bam @@ -220,9 +220,11 @@ workflow CHIPSEQ { return [ meta, bam ] paired_end: !meta.single_end return [ meta, bam ] - }.set { ch_genome_bam_chromap } + } + .set { ch_genome_bam_chromap } - ch_genome_bam_chromap.paired_end + ch_genome_bam_chromap + .paired_end .collect() .map { it -> @@ -264,7 +266,7 @@ workflow CHIPSEQ { } // - // SUBWORKFLOW: Merge resequenced BAM files + // MODULE: Merge resequenced BAM files // ch_genome_bam .map { @@ -306,7 +308,7 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(FILTER_BAM_BAMTOOLS.out.versions.first().ifEmpty(null)) // - // MODULE: Library coverage + // MODULE: Preseq coverage analysis // ch_preseq_multiqc = Channel.empty() if (!params.skip_preseq) { @@ -318,7 +320,7 @@ workflow CHIPSEQ { } // - // MODULE: Post alignment QC + // MODULE: Picard post alignment QC // ch_picardcollectmultiplemetrics_multiqc = Channel.empty() if (!params.skip_picard_metrics) { @@ -332,13 +334,16 @@ workflow CHIPSEQ { } // - // MODULE: Strand cross-correlation + // MODULE: Phantompeaktools strand cross-correlation and QC metrics // PHANTOMPEAKQUALTOOLS ( FILTER_BAM_BAMTOOLS.out.bam ) ch_versions = ch_versions.mix(PHANTOMPEAKQUALTOOLS.out.versions.first()) + // + // MODULE: MultiQC custom content for Phantompeaktools + // MULTIQC_CUSTOM_PHANTOMPEAKQUALTOOLS ( PHANTOMPEAKQUALTOOLS.out.spp.join(PHANTOMPEAKQUALTOOLS.out.rdata, by: [0]), ch_spp_nsc_header, @@ -347,7 +352,7 @@ workflow CHIPSEQ { ) // - // MODULE: Coverage tracks + // MODULE: BedGraph coverage tracks // BEDTOOLS_GENOMECOV ( FILTER_BAM_BAMTOOLS.out.bam.join(FILTER_BAM_BAMTOOLS.out.flagstat, by: [0]) @@ -355,7 +360,7 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(BEDTOOLS_GENOMECOV.out.versions.first()) // - // MODULE: Coverage tracks + // MODULE: BigWig coverage tracks // UCSC_BEDGRAPHTOBIGWIG ( BEDTOOLS_GENOMECOV.out.bedgraph, @@ -363,23 +368,29 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(UCSC_BEDGRAPHTOBIGWIG.out.versions.first()) - // - // MODULE: Coverage plots - // ch_deeptoolsplotprofile_multiqc = Channel.empty() if (!params.skip_plot_profile) { + // + // MODULE: deepTools matrix generation for plotting + // DEEPTOOLS_COMPUTEMATRIX ( UCSC_BEDGRAPHTOBIGWIG.out.bigwig, PREPARE_GENOME.out.gene_bed ) ch_versions = ch_versions.mix(DEEPTOOLS_COMPUTEMATRIX.out.versions.first()) + // + // MODULE: deepTools profile plots + // DEEPTOOLS_PLOTPROFILE ( DEEPTOOLS_COMPUTEMATRIX.out.matrix ) ch_deeptoolsplotprofile_multiqc = DEEPTOOLS_PLOTPROFILE.out.table ch_versions = ch_versions.mix(DEEPTOOLS_PLOTPROFILE.out.versions.first()) + // + // MODULE: deepTools heatmaps + // DEEPTOOLS_PLOTHEATMAP ( DEEPTOOLS_COMPUTEMATRIX.out.matrix ) @@ -387,7 +398,7 @@ workflow CHIPSEQ { } // - // Refactor channels: [ meta, [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] + // Create channels: [ meta, [ ip_bam, control_bam ] [ ip_bai, control_bai ] ] // FILTER_BAM_BAMTOOLS .out @@ -404,7 +415,7 @@ workflow CHIPSEQ { .set { ch_ip_control_bam_bai } // - // plotFingerprint for IP and control together + // MODULE: deepTools plotFingerprint joint QC for IP and control // ch_deeptoolsplotfingerprint_multiqc = Channel.empty() if (!params.skip_plot_fingerprint) { @@ -416,7 +427,7 @@ workflow CHIPSEQ { } // - // Call peaks + // MODULE: Calculute genome size with khmer // ch_macs_gsize = Channel.empty() ch_custompeaks_frip_multiqc = Channel.empty() @@ -432,7 +443,7 @@ workflow CHIPSEQ { ch_macs_gsize = KHMER_UNIQUEKMERS.out.kmers.map { it.text.trim() } } - // Create channel: [ meta, ip_bam, control_bam ] + // Create channels: [ meta, ip_bam, control_bam ] ch_ip_control_bam_bai .map { meta, bams, bais -> @@ -440,6 +451,9 @@ workflow CHIPSEQ { } .set { ch_ip_control_bam } + // + // MODULE: Call peaks with MACS2 + // MACS2_CALLPEAK ( ch_ip_control_bam, ch_macs_gsize @@ -447,7 +461,7 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(MACS2_CALLPEAK.out.versions.first()) // - // Filter for MACS2 files without peaks + // Filter out samples with 0 MACS2 peaks called // MACS2_CALLPEAK .out @@ -455,7 +469,7 @@ workflow CHIPSEQ { .filter { meta, peaks -> peaks.size() > 0 } .set { ch_macs2_peaks } - // Create channel: [ meta, ip_bam, peaks ] + // Create channels: [ meta, ip_bam, peaks ] ch_ip_control_bam .join(ch_macs2_peaks, by: [0]) .map { @@ -464,12 +478,15 @@ workflow CHIPSEQ { } .set { ch_ip_bam_peaks } + // + // MODULE: Calculate FRiP score + // FRIP_SCORE ( ch_ip_bam_peaks ) ch_versions = ch_versions.mix(FRIP_SCORE.out.versions.first()) - // Create channel: [ meta, peaks, frip ] + // Create channels: [ meta, peaks, frip ] ch_ip_bam_peaks .join(FRIP_SCORE.out.txt, by: [0]) .map { @@ -478,6 +495,9 @@ workflow CHIPSEQ { } .set { ch_ip_peaks_frip } + // + // MODULE: FRiP score custom content for MultiQC + // MULTIQC_CUSTOM_PEAKS ( ch_ip_peaks_frip, ch_peak_count_header, @@ -487,6 +507,9 @@ workflow CHIPSEQ { ch_custompeaks_count_multiqc = MULTIQC_CUSTOM_PEAKS.out.count if (!params.skip_peak_annotation) { +| // + // MODULE: Annotate peaks with MACS2 + // HOMER_ANNOTATEPEAKS_MACS2 ( ch_macs2_peaks, PREPARE_GENOME.out.fasta, @@ -495,11 +518,17 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_MACS2.out.versions.first()) if (!params.skip_peak_qc) { + // + // MODULE: MACS2 QC plots with R + // PLOT_MACS2_QC ( ch_macs2_peaks.collect{it[1]} ) ch_versions = ch_versions.mix(PLOT_MACS2_QC.out.versions) + // + // MODULE: Peak annotation QC plots with R + // PLOT_HOMER_ANNOTATEPEAKS ( HOMER_ANNOTATEPEAKS_MACS2.out.txt.collect{it[1]}, ch_peak_annotation_header, @@ -517,7 +546,7 @@ workflow CHIPSEQ { ch_deseq2_pca_multiqc = Channel.empty() ch_deseq2_clustering_multiqc = Channel.empty() if (!params.skip_consensus_peaks) { - // Create channel: [ meta , [ peaks ] ] + // Create channels: [ meta , [ peaks ] ] // Where meta = [ id:antibody, multiple_groups:true/false, replicates_exist:true/false ] ch_macs2_peaks .map { @@ -543,6 +572,9 @@ workflow CHIPSEQ { } .set { ch_antibody_peaks } + // + // MODULE: Generate consensus peaks across samples + // MACS2_CONSENSUS ( ch_antibody_peaks ) @@ -550,6 +582,9 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(MACS2_CONSENSUS.out.versions) if (!params.skip_peak_annotation) { + // + // MODULE: Annotate consensus peaks + // HOMER_ANNOTATEPEAKS_CONSENSUS ( MACS2_CONSENSUS.out.bed, PREPARE_GENOME.out.fasta, @@ -557,13 +592,16 @@ workflow CHIPSEQ { ) ch_versions = ch_versions.mix(HOMER_ANNOTATEPEAKS_CONSENSUS.out.versions) + // + // MODULE: Add boolean fields to annotated consensus peaks to aid filtering + // ANNOTATE_BOOLEAN_PEAKS ( MACS2_CONSENSUS.out.boolean_txt.join(HOMER_ANNOTATEPEAKS_CONSENSUS.out.txt, by: [0]), ) ch_versions = ch_versions.mix(ANNOTATE_BOOLEAN_PEAKS.out.versions) } - // Create channel: [ antibody, [ ip_bams ] ] + // Create channels: [ antibody, [ ip_bams ] ] ch_ip_control_bam .map { meta, ip_bam, control_bam -> @@ -572,7 +610,7 @@ workflow CHIPSEQ { .groupTuple() .set { ch_antibody_bams } - // Create channel: [ meta, [ ip_bams ], saf ] + // Create channels: [ meta, [ ip_bams ], saf ] MACS2_CONSENSUS .out .saf @@ -587,6 +625,9 @@ workflow CHIPSEQ { } .set { ch_saf_bams } + // + // MODULE: Quantify peaks across samples with featureCounts + // SUBREAD_FEATURECOUNTS ( ch_saf_bams ) @@ -594,6 +635,9 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(SUBREAD_FEATURECOUNTS.out.versions.first()) if (!params.skip_deseq2_qc) { + // + // MODULE: Generate QC plots with DESeq2 + // DESEQ2_QC ( SUBREAD_FEATURECOUNTS.out.counts, ch_deseq2_pca_header, @@ -605,7 +649,7 @@ workflow CHIPSEQ { } // - // Create IGV session + // MODULE: Create IGV session // if (!params.skip_igv) { IGV ( From 42feb6f2e431a783af265943f9c8ef6de259f663 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Thu, 15 Sep 2022 13:35:17 +0100 Subject: [PATCH 523/538] Fix bug --- workflows/chipseq.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 01ec3eb90..db6699e4d 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -507,7 +507,7 @@ workflow CHIPSEQ { ch_custompeaks_count_multiqc = MULTIQC_CUSTOM_PEAKS.out.count if (!params.skip_peak_annotation) { -| // + // // MODULE: Annotate peaks with MACS2 // HOMER_ANNOTATEPEAKS_MACS2 ( From 9e83c05e193cb508df03d02d7070128cfd0411af Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Thu, 15 Sep 2022 13:38:27 +0100 Subject: [PATCH 524/538] Fix prettier --- nextflow_schema.json | 28 ++++------------------------ 1 file changed, 4 insertions(+), 24 deletions(-) diff --git a/nextflow_schema.json b/nextflow_schema.json index 839dc19e8..2a5f445c9 100644 --- a/nextflow_schema.json +++ b/nextflow_schema.json @@ -10,9 +10,7 @@ "type": "object", "fa_icon": "fas fa-terminal", "description": "Define where the pipeline should find input data and save output data.", - "required": [ - "outdir" - ], + "required": ["outdir"], "properties": { "input": { "type": "string", @@ -39,13 +37,7 @@ "type": "integer", "description": "Read length used to calculate MACS2 genome size for peak calling if `--macs_gsize` isn't provided.", "fa_icon": "fas fa-chart-area", - "enum": [ - 50, - 75, - 100, - 150, - 200 - ] + "enum": [50, 75, 100, 150, 200] }, "outdir": { "type": "string", @@ -229,12 +221,7 @@ "default": "bwa", "description": "Specifies the alignment algorithm to use - available options are 'bwa', 'bowtie2' and 'star'.", "fa_icon": "fas fa-map-signs", - "enum": [ - "bwa", - "bowtie2", - "chromap", - "star" - ] + "enum": ["bwa", "bowtie2", "chromap", "star"] }, "keep_dups": { "type": "boolean", @@ -503,14 +490,7 @@ "description": "Method used to save pipeline results to output directory.", "help_text": "The Nextflow `publishDir` option specifies which intermediate files should be saved to the output directory. This option tells the pipeline what method should be used to move these files. See [Nextflow docs](https://www.nextflow.io/docs/latest/process.html#publishdir) for details.", "fa_icon": "fas fa-copy", - "enum": [ - "symlink", - "rellink", - "link", - "copy", - "copyNoFollow", - "move" - ], + "enum": ["symlink", "rellink", "link", "copy", "copyNoFollow", "move"], "hidden": true }, "fingerprint_bins": { From e7c55164d3b0f51c70dfe7e629fba41c68c7e29e Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Thu, 15 Sep 2022 15:19:31 +0100 Subject: [PATCH 525/538] Update docs/output.md Co-authored-by: Jose Espinosa-Carrasco --- docs/output.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/docs/output.md b/docs/output.md index 9dd852ebb..b2c9bd0d9 100644 --- a/docs/output.md +++ b/docs/output.md @@ -261,7 +261,7 @@ The [featureCounts](http://bioinf.wehi.edu.au/featureCounts/) tool is used to co **This pipeline uses a standardised DESeq2 analysis script to get an idea of the reproducibility within the experiment, and to assess the overall differential binding. Please note that this will not suit every experimental design, and if there are other problems with the experiment then it may not work as well as expected.** -For larger experiments, it is recommended to use the `vst` transformation instead of the default `rlog` option. This is the default behaviour and can be controlled with the `--deseq2_vst` parameter. See [DESeq2 docs](http://bioconductor.org/packages/devel/bioc/vignettes/DESeq2/inst/doc/DESeq2.html#data-transformations-and-visualization) for a more detailed explanation. +For larger experiments, it is recommended to use the `vst` transformation instead of the `rlog` option. This is the default behaviour and can be controlled with the `--deseq2_vst` parameter. See [DESeq2 docs](http://bioconductor.org/packages/devel/bioc/vignettes/DESeq2/inst/doc/DESeq2.html#data-transformations-and-visualization) for a more detailed explanation. ![MultiQC - DESeq2 PCA plot](images/mqc_deseq2_pca_plot.png) From a32cef82c21e914cec065bc2515863fd76d64eec Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Thu, 15 Sep 2022 16:55:30 +0200 Subject: [PATCH 526/538] Add missing ending tag --- docs/output.md | 2 ++ 1 file changed, 2 insertions(+) diff --git a/docs/output.md b/docs/output.md index b2c9bd0d9..604310b57 100644 --- a/docs/output.md +++ b/docs/output.md @@ -97,6 +97,8 @@ The `--save_unaligned` parameter enables to obtain FastQ files containing unmapp - `*.Log.final.out`: STAR alignment report containing the mapping results summary. - `*.Log.out` and `*.Log.progress.out`: STAR log files containing detailed information about the run. Typically only useful for debugging purposes. +
+ ## Merged library-level analysis The library-level alignments associated with the same sample are merged and subsequently used for the downstream analyses. From ce0ed8d5250cc97a3b11d80a89ba70739b2746fe Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Fri, 16 Sep 2022 12:08:06 +0100 Subject: [PATCH 527/538] Remove redundanct comment --- workflows/chipseq.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index db6699e4d..06b95b37f 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -297,7 +297,7 @@ workflow CHIPSEQ { ch_versions = ch_versions.mix(MARK_DUPLICATES_PICARD.out.versions) // - // SUBWORKFLOW: Fix getting name sorted BAM here for PE/SE + // SUBWORKFLOW: Filter BAM file with BamTools // FILTER_BAM_BAMTOOLS ( MARK_DUPLICATES_PICARD.out.bam.join(MARK_DUPLICATES_PICARD.out.bai, by: [0]), From bcc970266308a4ae98edad252cfdeb2a61a4feab Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Fri, 16 Sep 2022 12:08:21 +0100 Subject: [PATCH 528/538] Change find command to be more specific --- modules/local/plot_homer_annotatepeaks.nf | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/modules/local/plot_homer_annotatepeaks.nf b/modules/local/plot_homer_annotatepeaks.nf index 11ed3daba..3375349a1 100644 --- a/modules/local/plot_homer_annotatepeaks.nf +++ b/modules/local/plot_homer_annotatepeaks.nf @@ -27,7 +27,7 @@ process PLOT_HOMER_ANNOTATEPEAKS { -p $prefix \\ $args - find ./ -type f -name "*.txt" -exec cat {} \\; | cat $mqc_header - > ${prefix}.summary_mqc.tsv + find ./ -type f -name "*summary.txt" -exec cat {} \\; | cat $mqc_header - > ${prefix}.summary_mqc.tsv cat <<-END_VERSIONS > versions.yml "${task.process}": From 255992d467e6519b1ea76bfa5d2ccfd82152f704 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Fri, 16 Sep 2022 12:22:41 +0100 Subject: [PATCH 529/538] Add tower.yml to render Reports for main files on Tower --- tower.yml | 19 +++++++++++++++++++ 1 file changed, 19 insertions(+) create mode 100644 tower.yml diff --git a/tower.yml b/tower.yml new file mode 100644 index 000000000..5b1f5f906 --- /dev/null +++ b/tower.yml @@ -0,0 +1,19 @@ +reports: + multiqc_report.html: + display: "MultiQC HTML report" + macs2_peak.plots.pdf: + display: "All samples MACS2 peak QC PDF plots" + macs2_annotatePeaks.plots.pdf: + display: "All samples HOMER annotatePeaks.pl QC PDF plots" + "*.consensus_peaks.plots.pdf": + display: "Consensus peaks DESeq2 QC PDF plots" + "*.consensus_peaks.boolean.intersect.plot.pdf": + display: "Consensus peaks UpSetR intersection PDF plots" + "*.consensus_peaks.boolean.annotatePeaks.txt": + display: "Consensus peaks annotated by HOMER" + "*.plotHeatmap.pdf": + display: "Per-sample deepTools plotHeatmap PDF plots" + "*_peaks.broadPeak": + display: "Per-sample MACS2 broadPeak file" + "*_peaks.narrowPeak": + display: "Per-sample MACS2 narrowPeak file" From 3ed06fa0c0fe9d868ec04c5bd4ff689cce4f81d7 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Sun, 2 Oct 2022 00:44:06 +0100 Subject: [PATCH 530/538] Remove pinning for R packages used in DESeq2 script --- modules/local/deseq2_qc.nf | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/modules/local/deseq2_qc.nf b/modules/local/deseq2_qc.nf index 7fc5a9f2a..84ff0d5f0 100644 --- a/modules/local/deseq2_qc.nf +++ b/modules/local/deseq2_qc.nf @@ -2,7 +2,9 @@ process DESEQ2_QC { tag "$meta.id" label 'process_medium' - conda (params.enable_conda ? "conda-forge::r-base=4.0 bioconda::bioconductor-deseq2=1.28.0 bioconda::bioconductor-biocparallel bioconda::bioconductor-tximport bioconda::bioconductor-complexheatmap conda-forge::r-optparse conda-forge::r-ggplot2 conda-forge::r-rcolorbrewer conda-forge::r-pheatmap" : null) + // (Bio)conda packages have intentionally not been pinned to a specific version + // This was to avoid the pipeline failing due to package conflicts whilst creating the environment when using -profile conda + conda (params.enable_conda ? "conda-forge::r-base bioconda::bioconductor-deseq2 bioconda::bioconductor-biocparallel bioconda::bioconductor-tximport bioconda::bioconductor-complexheatmap conda-forge::r-optparse conda-forge::r-ggplot2 conda-forge::r-rcolorbrewer conda-forge::r-pheatmap" : null) container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ? 'https://depot.galaxyproject.org/singularity/mulled-v2-8849acf39a43cdd6c839a369a74c0adc823e2f91:ab110436faf952a33575c64dd74615a84011450b-0' : 'quay.io/biocontainers/mulled-v2-8849acf39a43cdd6c839a369a74c0adc823e2f91:ab110436faf952a33575c64dd74615a84011450b-0' }" From 09ca349448aaeaa97ff5abb3c3cdc752872fcb98 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Sun, 2 Oct 2022 00:48:48 +0100 Subject: [PATCH 531/538] Add antibody directory to consensus peaks in IGV session --- modules/local/igv.nf | 23 +++++++++++++---------- modules/local/macs2_consensus.nf | 4 +++- workflows/chipseq.nf | 21 +++++---------------- 3 files changed, 21 insertions(+), 27 deletions(-) diff --git a/modules/local/igv.nf b/modules/local/igv.nf index 8578092b4..a500072c0 100644 --- a/modules/local/igv.nf +++ b/modules/local/igv.nf @@ -9,28 +9,31 @@ process IGV { 'quay.io/biocontainers/python:3.8.3' }" input: + val aligner_dir + val peak_dir path fasta - path ("${bigwig_publish_dir}/*") - path ("${peak_publish_dir}/*") - path ("${consensus_publish_dir}/*") - val bigwig_publish_dir - val peak_publish_dir - val consensus_publish_dir - + path ("${aligner_dir}/mergedLibrary/bigwig/*") + path ("${aligner_dir}/mergedLibrary/macs2/${peak_dir}/*") + path ("${aligner_dir}/mergedLibrary/macs2/${peak_dir}/consensus/*") + path ("mappings/*") + output: path "*files.txt" , emit: txt path "*.xml" , emit: xml path "versions.yml", emit: versions script: // scripts are bundled with the pipeline in nf-core/chipseq/bin/ + def consensus_dir = "${aligner_dir}/mergedLibrary/macs2/${peak_dir}/consensus/*" """ find * -type l -name "*.bigWig" -exec echo -e ""{}"\\t0,0,178" \\; > bigwig.igv.txt find * -type l -name "*Peak" -exec echo -e ""{}"\\t0,0,178" \\; > peaks.igv.txt # Avoid error when consensus not produced - find * -type l -name "*.bed" -exec echo -e ""{}"\\t0,0,178" \\; | { grep "^$consensus_publish_dir" || test \$? = 1; } > bed.igv.txt + find * -type l -name "*.bed" -exec echo -e ""{}"\\t0,0,178" \\; | { grep "^$consensus_dir" || test \$? = 1; } > consensus.igv.txt + + cat mappings/* > replace_paths.txt - cat *.txt > igv_files.txt - igv_files_to_session.py igv_session.xml igv_files.txt ../../genome/${fasta.getName()} --path_prefix '../../' + cat *.igv.txt > igv_files_orig.txt + igv_files_to_session.py igv_session.xml igv_files_orig.txt replace_paths.txt ../../genome/${fasta.getName()} --path_prefix '../../' cat <<-END_VERSIONS > versions.yml "${task.process}": diff --git a/modules/local/macs2_consensus.nf b/modules/local/macs2_consensus.nf index f28dc732e..ab9ef93a2 100644 --- a/modules/local/macs2_consensus.nf +++ b/modules/local/macs2_consensus.nf @@ -17,6 +17,7 @@ process MACS2_CONSENSUS { tuple val(meta), path("*.bed") , emit: bed tuple val(meta), path("*.saf") , emit: saf tuple val(meta), path("*.pdf") , emit: pdf + tuple val(meta), path("*.antibody.txt") , emit: txt tuple val(meta), path("*.boolean.txt") , emit: boolean_txt tuple val(meta), path("*.intersect.txt"), emit: intersect_txt path "versions.yml" , emit: versions @@ -25,7 +26,6 @@ process MACS2_CONSENSUS { task.ext.when == null || task.ext.when script: // This script is bundled with the pipeline, in nf-core/chipseq/bin/ - def prefix = task.ext.prefix ?: "${meta.id}" def peak_type = params.narrow_peak ? 'narrowPeak' : 'broadPeak' def mergecols = params.narrow_peak ? (2..10).join(',') : (2..9).join(',') @@ -49,6 +49,8 @@ process MACS2_CONSENSUS { plot_peak_intersect.r -i ${prefix}.boolean.intersect.txt -o ${prefix}.boolean.intersect.plot.pdf + echo "${prefix}.bed\t${meta.id}/${prefix}.bed" > ${prefix}.antibody.txt + cat <<-END_VERSIONS > versions.yml "${task.process}": python: \$(python --version | sed 's/Python //g') diff --git a/workflows/chipseq.nf b/workflows/chipseq.nf index 06b95b37f..ffe995186 100644 --- a/workflows/chipseq.nf +++ b/workflows/chipseq.nf @@ -543,6 +543,7 @@ workflow CHIPSEQ { // Consensus peaks analysis // ch_macs2_consensus_bed_lib = Channel.empty() + ch_macs2_consensus_txt_lib = Channel.empty() ch_deseq2_pca_multiqc = Channel.empty() ch_deseq2_clustering_multiqc = Channel.empty() if (!params.skip_consensus_peaks) { @@ -579,6 +580,7 @@ workflow CHIPSEQ { ch_antibody_peaks ) ch_macs2_consensus_bed_lib = MACS2_CONSENSUS.out.bed + ch_macs2_consensus_txt_lib = MACS2_CONSENSUS.out.txt ch_versions = ch_versions.mix(MACS2_CONSENSUS.out.versions) if (!params.skip_peak_annotation) { @@ -653,26 +655,13 @@ workflow CHIPSEQ { // if (!params.skip_igv) { IGV ( + params.aligner, + params.narrow_peak ? 'narrowPeak' : 'broadPeak', PREPARE_GENOME.out.fasta, UCSC_BEDGRAPHTOBIGWIG.out.bigwig.collect{it[1]}.ifEmpty([]), ch_macs2_peaks.collect{it[1]}.ifEmpty([]), ch_macs2_consensus_bed_lib.collect{it[1]}.ifEmpty([]), - { "${params.aligner}/mergedLibrary/bigwig" }, - { - [ - "${params.aligner}/mergedLibrary/macs2", - params.narrow_peak ? '/narrowPeak' : '/broadPeak' - ] - .join('') - }, - { - [ - "${params.aligner}/mergedLibrary/macs2", - params.narrow_peak ? '/narrowPeak' : '/broadPeak', - '/consensus' - ] - .join('') - } + ch_macs2_consensus_txt_lib.collect{it[1]}.ifEmpty([]) ) ch_versions = ch_versions.mix(IGV.out.versions) } From 80fd01c0b2f3c929fe90ef573456248fd6c5c242 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Sun, 2 Oct 2022 00:49:44 +0100 Subject: [PATCH 532/538] Update date in CHANGELOG --- CHANGELOG.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 289c062c2..1f475919c 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -3,7 +3,7 @@ The format is based on [Keep a Changelog](https://keepachangelog.com/en/1.0.0/) and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.html). -## [[2.0.0](https://github.com/nf-core/chipseq/releases/tag/2.0.0)] - 2022-09-30 +## [[2.0.0](https://github.com/nf-core/chipseq/releases/tag/2.0.0)] - 2022-10-03 ### Enhancements & fixes From 40db9a5504d2a9f925175f92d10b4f43d0060aa9 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Sun, 2 Oct 2022 01:06:35 +0100 Subject: [PATCH 533/538] Update igv_files_to_session.py script --- bin/igv_files_to_session.py | 28 +++++++++++++++++++++++++--- 1 file changed, 25 insertions(+), 3 deletions(-) diff --git a/bin/igv_files_to_session.py b/bin/igv_files_to_session.py index ce1fac70f..f10453eec 100755 --- a/bin/igv_files_to_session.py +++ b/bin/igv_files_to_session.py @@ -26,6 +26,9 @@ argParser.add_argument( "LIST_FILE", help="Tab-delimited file containing two columns i.e. file_name\tcolour. Header isnt required." ) +argParser.add_argument( + "REPLACE_FILE", help="Tab-delimited file containing two columns i.e. file_name\treplacement_file_name. Header isnt required." +) argParser.add_argument( "GENOME", help="Full path to genome fasta file or shorthand for genome available in IGV e.g. hg19." ) @@ -65,10 +68,21 @@ def makedir(path): ############################################ -def igv_files_to_session(XMLOut, ListFile, Genome, PathPrefix=""): +def igv_files_to_session(XMLOut, ListFile, ReplaceFile, Genome, PathPrefix=""): makedir(os.path.dirname(XMLOut)) + replaceFileDict = {} + fin = open(ReplaceFile, "r") + while True: + line = fin.readline() + if line: + ofile, rfile = line.strip().split("\t") + replaceFileDict[ofile] = rfile + else: + break + fin.close() + fileList = [] fin = open(ListFile, "r") while True: @@ -77,10 +91,18 @@ def igv_files_to_session(XMLOut, ListFile, Genome, PathPrefix=""): ifile, colour = line.strip().split("\t") if len(colour.strip()) == 0: colour = "0,0,178" + for ofile,rfile in replaceFileDict.items(): + if ofile in ifile: + ifile = ifile.replace(ofile, rfile) fileList.append((PathPrefix.strip() + ifile, colour)) else: break - fout.close() + fin.close() + + fout = open('igv_files.txt', "w") + for ifile, colour in fileList: + fout.write(ifile + '\n') + fout.close() ## ADD RESOURCES SECTION XMLStr = '\n' @@ -153,7 +175,7 @@ def igv_files_to_session(XMLOut, ListFile, Genome, PathPrefix=""): ############################################ ############################################ -igv_files_to_session(XMLOut=args.XML_OUT, ListFile=args.LIST_FILE, Genome=args.GENOME, PathPrefix=args.PATH_PREFIX) +igv_files_to_session(XMLOut=args.XML_OUT, ListFile=args.LIST_FILE, ReplaceFile=args.REPLACE_FILE, Genome=args.GENOME, PathPrefix=args.PATH_PREFIX) ############################################ ############################################ From 6f8a372b6fb9c70c2846a3fb40af84174867c09f Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Sun, 2 Oct 2022 09:29:21 +0100 Subject: [PATCH 534/538] Fix if no consensus peaks are provided --- modules/local/igv.nf | 7 +++++-- 1 file changed, 5 insertions(+), 2 deletions(-) diff --git a/modules/local/igv.nf b/modules/local/igv.nf index a500072c0..137abbb4b 100644 --- a/modules/local/igv.nf +++ b/modules/local/igv.nf @@ -30,8 +30,11 @@ process IGV { # Avoid error when consensus not produced find * -type l -name "*.bed" -exec echo -e ""{}"\\t0,0,178" \\; | { grep "^$consensus_dir" || test \$? = 1; } > consensus.igv.txt - cat mappings/* > replace_paths.txt - + touch replace_paths.txt + if [ -d "mappings" ]; then + cat mappings/* > replace_paths.txt + fi + cat *.igv.txt > igv_files_orig.txt igv_files_to_session.py igv_session.xml igv_files_orig.txt replace_paths.txt ../../genome/${fasta.getName()} --path_prefix '../../' From 6428b3f9a18f75a711716d364c2f88f80e9ccf36 Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Sun, 2 Oct 2022 09:31:06 +0100 Subject: [PATCH 535/538] Black --- bin/igv_files_to_session.py | 39 ++++++++++++++++++++++++------------- 1 file changed, 26 insertions(+), 13 deletions(-) diff --git a/bin/igv_files_to_session.py b/bin/igv_files_to_session.py index f10453eec..08e5adf98 100755 --- a/bin/igv_files_to_session.py +++ b/bin/igv_files_to_session.py @@ -17,20 +17,25 @@ ############################################ Description = 'Create IGV session file from a list of files and associated colours - ".bed", ".bw", ".bigwig", ".tdf", ".gtf" files currently supported.' -Epilog = """Example usage: python igv_files_to_session.py """ +Epilog = ( + """Example usage: python igv_files_to_session.py """ +) argParser = argparse.ArgumentParser(description=Description, epilog=Epilog) ## REQUIRED PARAMETERS argParser.add_argument("XML_OUT", help="XML output file.") argParser.add_argument( - "LIST_FILE", help="Tab-delimited file containing two columns i.e. file_name\tcolour. Header isnt required." + "LIST_FILE", + help="Tab-delimited file containing two columns i.e. file_name\tcolour. Header isnt required.", ) argParser.add_argument( - "REPLACE_FILE", help="Tab-delimited file containing two columns i.e. file_name\treplacement_file_name. Header isnt required." + "REPLACE_FILE", + help="Tab-delimited file containing two columns i.e. file_name\treplacement_file_name. Header isnt required.", ) argParser.add_argument( - "GENOME", help="Full path to genome fasta file or shorthand for genome available in IGV e.g. hg19." + "GENOME", + help="Full path to genome fasta file or shorthand for genome available in IGV e.g. hg19.", ) ## OPTIONAL PARAMETERS @@ -82,7 +87,6 @@ def igv_files_to_session(XMLOut, ListFile, ReplaceFile, Genome, PathPrefix=""): else: break fin.close() - fileList = [] fin = open(ListFile, "r") while True: @@ -91,22 +95,24 @@ def igv_files_to_session(XMLOut, ListFile, ReplaceFile, Genome, PathPrefix=""): ifile, colour = line.strip().split("\t") if len(colour.strip()) == 0: colour = "0,0,178" - for ofile,rfile in replaceFileDict.items(): + for ofile, rfile in replaceFileDict.items(): if ofile in ifile: ifile = ifile.replace(ofile, rfile) fileList.append((PathPrefix.strip() + ifile, colour)) else: break fin.close() - - fout = open('igv_files.txt', "w") + fout = open("igv_files.txt", "w") for ifile, colour in fileList: - fout.write(ifile + '\n') + fout.write(ifile + "\n") fout.close() ## ADD RESOURCES SECTION XMLStr = '\n' - XMLStr += '\n' % (Genome) + XMLStr += ( + '\n' + % (Genome) + ) XMLStr += "\t\n" for ifile, colour in fileList: XMLStr += '\t\t\n' % (ifile) @@ -143,7 +149,9 @@ def igv_files_to_session(XMLOut, ListFile, ReplaceFile, Genome, PathPrefix=""): '\t\t\n' % (ifile, os.path.basename(ifile)) @@ -160,7 +168,6 @@ def igv_files_to_session(XMLOut, ListFile, ReplaceFile, Genome, PathPrefix=""): 'id="%s" name="%s" renderer="BASIC_FEATURE" sortable="false" visible="true" windowFunction="count"/>\n' % (ifile, os.path.basename(ifile)) ) - XMLStr += "\t\n" # XMLStr += '\t\n\t\t\n\t\t\n\t\t\n\t\n' XMLStr += "" @@ -175,7 +182,13 @@ def igv_files_to_session(XMLOut, ListFile, ReplaceFile, Genome, PathPrefix=""): ############################################ ############################################ -igv_files_to_session(XMLOut=args.XML_OUT, ListFile=args.LIST_FILE, ReplaceFile=args.REPLACE_FILE, Genome=args.GENOME, PathPrefix=args.PATH_PREFIX) +igv_files_to_session( + XMLOut=args.XML_OUT, + ListFile=args.LIST_FILE, + ReplaceFile=args.REPLACE_FILE, + Genome=args.GENOME, + PathPrefix=args.PATH_PREFIX, +) ############################################ ############################################ From ed10bb9d2ad4c758b7157b25a16d157cfbc6259d Mon Sep 17 00:00:00 2001 From: Harshil Patel Date: Sun, 2 Oct 2022 11:48:10 +0100 Subject: [PATCH 536/538] Fix linting --- bin/igv_files_to_session.py | 13 +++---------- modules/local/igv.nf | 4 ++-- 2 files changed, 5 insertions(+), 12 deletions(-) diff --git a/bin/igv_files_to_session.py b/bin/igv_files_to_session.py index 08e5adf98..629e6cc91 100755 --- a/bin/igv_files_to_session.py +++ b/bin/igv_files_to_session.py @@ -17,9 +17,7 @@ ############################################ Description = 'Create IGV session file from a list of files and associated colours - ".bed", ".bw", ".bigwig", ".tdf", ".gtf" files currently supported.' -Epilog = ( - """Example usage: python igv_files_to_session.py """ -) +Epilog = """Example usage: python igv_files_to_session.py """ argParser = argparse.ArgumentParser(description=Description, epilog=Epilog) @@ -109,10 +107,7 @@ def igv_files_to_session(XMLOut, ListFile, ReplaceFile, Genome, PathPrefix=""): ## ADD RESOURCES SECTION XMLStr = '\n' - XMLStr += ( - '\n' - % (Genome) - ) + XMLStr += '\n' % (Genome) XMLStr += "\t\n" for ifile, colour in fileList: XMLStr += '\t\t\n' % (ifile) @@ -149,9 +144,7 @@ def igv_files_to_session(XMLOut, ListFile, ReplaceFile, Genome, PathPrefix=""): '\t\t\n' % (ifile, os.path.basename(ifile)) diff --git a/modules/local/igv.nf b/modules/local/igv.nf index 137abbb4b..213904b3e 100644 --- a/modules/local/igv.nf +++ b/modules/local/igv.nf @@ -16,7 +16,7 @@ process IGV { path ("${aligner_dir}/mergedLibrary/macs2/${peak_dir}/*") path ("${aligner_dir}/mergedLibrary/macs2/${peak_dir}/consensus/*") path ("mappings/*") - + output: path "*files.txt" , emit: txt path "*.xml" , emit: xml @@ -34,7 +34,7 @@ process IGV { if [ -d "mappings" ]; then cat mappings/* > replace_paths.txt fi - + cat *.igv.txt > igv_files_orig.txt igv_files_to_session.py igv_session.xml igv_files_orig.txt replace_paths.txt ../../genome/${fasta.getName()} --path_prefix '../../' From f62ea83333b998fc544a746be8a18f276babb35c Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Sun, 2 Oct 2022 23:29:55 +0200 Subject: [PATCH 537/538] Add back antibody to consensus paths in output description --- docs/output.md | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/docs/output.md b/docs/output.md index 604310b57..b31985543 100644 --- a/docs/output.md +++ b/docs/output.md @@ -217,7 +217,7 @@ Various QC plots per sample including number of peaks, fold-change distribution,
Output files -- `/mergedLibrary/macs2//consensus` +- `/mergedLibrary/macs2//consensus//` - `*.bed`: Consensus peak-set across all samples in BED format. - `*.saf`: Consensus peak-set across all samples in SAF format. Required by featureCounts for read quantification. - `*.featureCounts.txt`: Read counts across all samples relative to consensus peak-set. @@ -245,7 +245,7 @@ The [featureCounts](http://bioinf.wehi.edu.au/featureCounts/) tool is used to co
Output files -- `/mergedLibrary/macs2//consensus/deseq2/` +- `/mergedLibrary/macs2//consensus//deseq2/` - `*.sample.dists.txt`: Spreadsheet containing sample-to-sample distance across each consensus peak. - `*.plots.pdf`: File containing PCA and hierarchical clustering plots. - `*.dds.RData`: File containing R `DESeqDataSet` object generated by DESeq2, with either @@ -254,7 +254,7 @@ The [featureCounts](http://bioinf.wehi.edu.au/featureCounts/) tool is used to co `readRDS` to give user control of the eventual object name. - `*pca.vals.txt`: Matrix of values for the first 2 principal components. - `R_sessionInfo.log`: File containing information about R, the OS and attached or loaded packages. - - `/mergedLibrary/macs2//consensus/deseq2/sizeFactors/` + - `/mergedLibrary/macs2//consensus//sizeFactors/` - `*.txt`, `*.RData`: Files containing DESeq2 sizeFactors per sample.
From f96dfd688068aa0036cfe9af3b6cb2093a7eda89 Mon Sep 17 00:00:00 2001 From: JoseEspinosa Date: Mon, 3 Oct 2022 16:41:28 +0200 Subject: [PATCH 538/538] Update changelog --- CHANGELOG.md | 1 - 1 file changed, 1 deletion(-) diff --git a/CHANGELOG.md b/CHANGELOG.md index 1f475919c..ea9b46068 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -25,7 +25,6 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0 - Eliminate `if` conditions from `deseq2_qc` and `macs2_consensus` (local module and use `ext.when` instead) - Remove `deseq2` differential binding analysis of consensus peaks. - [[280](https://github.com/nf-core/chipseq/issues/291) - Filter paired-end files produced by `chromap` since the resulting `BAM` files can not be processed downstream. -- Remove from the macs2 consensus publish directory since it can not be referred as input from the IGV process (meta.id not resolved at execution time) - Add bytesize link to readme. ### Parameters
\n" + for (param in group_params.keySet()) { + summary_section += "
$param
${group_params.get(param) ?: 'N/A'}
\n" + } + summary_section += "
\n" + for (param in group_params.keySet()) { + summary_section += "
$param
${group_params.get(param) ?: 'N/A'}
\n" + } + summary_section += "