diff --git a/newrelic/config.py b/newrelic/config.py
index 4e0912db8..292044a29 100644
--- a/newrelic/config.py
+++ b/newrelic/config.py
@@ -2162,11 +2162,6 @@ def _process_module_builtin_defaults():
     )
 
     _process_module_definition("flask_restful", "newrelic.hooks.component_flask_rest", "instrument_flask_rest")
-    _process_module_definition(
-        "flask_restplus.api",
-        "newrelic.hooks.component_flask_rest",
-        "instrument_flask_rest",
-    )
     _process_module_definition(
         "flask_restx.api",
         "newrelic.hooks.component_flask_rest",
diff --git a/tests/component_flask_rest/test_application.py b/tests/component_flask_rest/test_application.py
index 67d60bc53..934eb5784 100644
--- a/tests/component_flask_rest/test_application.py
+++ b/tests/component_flask_rest/test_application.py
@@ -30,14 +30,12 @@
 TEST_APPLICATION_PREFIX = "_test_application.create_app.<locals>" if six.PY3 else "_test_application"
 
 
-@pytest.fixture(params=["flask_restful", "flask_restplus", "flask_restx"])
+@pytest.fixture(params=["flask_restful", "flask_restx"])
 def application(request):
     from _test_application import get_test_application
 
     if request.param == "flask_restful":
         import flask_restful as module
-    elif request.param == "flask_restplus":
-        import flask_restplus as module
     elif request.param == "flask_restx":
         import flask_restx as module
     else:
diff --git a/tox.ini b/tox.ini
index 1fc5479d8..e06279107 100644
--- a/tox.ini
+++ b/tox.ini
@@ -206,11 +206,10 @@ deps =
     component_djangorestframework-djangorestframework0300: djangorestframework < 3.1
     component_djangorestframework-djangorestframeworklatest: Django
     component_djangorestframework-djangorestframeworklatest: djangorestframework
-    component_flask_rest: flask<0.13
+    component_flask_rest: flask
     component_flask_rest: flask-restful
-    component_flask_rest: flask-restplus
-    component_flask_rest: jinja2<3.1
-    component_flask_rest: itsdangerous<2.1
+    component_flask_rest: jinja2
+    component_flask_rest: itsdangerous
     component_flask_rest-flaskrestxlatest: flask-restx
     component_flask_rest-flaskrestx051: flask-restx<1.0
     component_graphqlserver: graphql-server[sanic,flask]==3.0.0b5