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Negative binomial null residuals #14

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willtownes opened this issue Aug 14, 2020 · 0 comments
Open

Negative binomial null residuals #14

willtownes opened this issue Aug 14, 2020 · 0 comments

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@willtownes
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As a user with data in a SingleCellExperiment, I can compute either Pearson or deviance negative binomial null residuals so that I can use them in downstream analysis.

  • data in dense matrix in memory
  • data in DelayedArray on disk
  • (maybe) sparse Matrix data in memory

Possible implementation paths:

  1. Wrap the sctransform CRAN package. This provides regularized negative binomial Pearson residuals. It doesn't appear to support disk-based data though.
  2. Do our own implementation with glmGamPoi package as backend for fast nb regression.
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