diff --git a/CHANGELOG.md b/CHANGELOG.md
index 43160fd7f324..d23b48285149 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -98,6 +98,7 @@
 - `[jest-runtime]` Fix mistake as test files when run coverage issue. ([#7506](https://github.com/facebook/jest/pull/7506))
 - `[jest-cli]` print info about passWithNoTests flag ([#7309](https://github.com/facebook/jest/pull/7309))
 - `[pretty-format]` Omit unnecessary symbol filter for object keys ([#7457](https://github.com/facebook/jest/pull/7457))
+- `[jest-runtime]` Fix `requireActual` on node_modules with mock present ([#7404](https://github.com/facebook/jest/pull/7404))
 
 ### Chore & Maintenance
 
diff --git a/packages/jest-runtime/src/__tests__/runtime_require_actual.test.js b/packages/jest-runtime/src/__tests__/runtime_require_actual.test.js
new file mode 100644
index 000000000000..9cbedf543008
--- /dev/null
+++ b/packages/jest-runtime/src/__tests__/runtime_require_actual.test.js
@@ -0,0 +1,26 @@
+/**
+ * Copyright (c) 2014-present, Facebook, Inc. All rights reserved.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ *
+ */
+
+'use strict';
+
+let createRuntime;
+
+describe('Runtime requireActual', () => {
+  beforeEach(() => {
+    createRuntime = require('createRuntime');
+  });
+
+  it('requires node module when manual mock exists', () =>
+    createRuntime(__filename).then(runtime => {
+      const exports = runtime.requireActual(
+        runtime.__mockRootPath,
+        'mocked-node-module',
+      );
+      expect(exports.isManualMockModule).toBe(false);
+    }));
+});
diff --git a/packages/jest-runtime/src/__tests__/test_root/__mocks__/mocked-node-module.js b/packages/jest-runtime/src/__tests__/test_root/__mocks__/mocked-node-module.js
new file mode 100644
index 000000000000..caa044941920
--- /dev/null
+++ b/packages/jest-runtime/src/__tests__/test_root/__mocks__/mocked-node-module.js
@@ -0,0 +1,11 @@
+/**
+ * Copyright (c) 2014-present, Facebook, Inc. All rights reserved.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ *
+ */
+
+'use strict';
+
+exports.isManualMockModule = true;
diff --git a/packages/jest-runtime/src/__tests__/test_root/node_modules/mocked-node-module/index.js b/packages/jest-runtime/src/__tests__/test_root/node_modules/mocked-node-module/index.js
new file mode 100644
index 000000000000..f64a42aaca22
--- /dev/null
+++ b/packages/jest-runtime/src/__tests__/test_root/node_modules/mocked-node-module/index.js
@@ -0,0 +1,11 @@
+/**
+ * Copyright (c) 2014-present, Facebook, Inc. All rights reserved.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ *
+ */
+
+'use strict';
+
+exports.isManualMockModule = false;
diff --git a/packages/jest-runtime/src/index.js b/packages/jest-runtime/src/index.js
index bb8be2d1824b..0d18f701c9b9 100644
--- a/packages/jest-runtime/src/index.js
+++ b/packages/jest-runtime/src/index.js
@@ -286,6 +286,7 @@ class Runtime {
     from: Path,
     moduleName?: string,
     options: ?InternalModuleOptions,
+    isRequireActual: ?boolean,
   ) {
     const moduleID = this._resolver.getModuleID(
       this._virtualMocks,
@@ -301,6 +302,7 @@ class Runtime {
       moduleName && this._resolver.getMockModule(from, moduleName);
     if (
       (!options || !options.isInternalModule) &&
+      !isRequireActual &&
       !moduleResource &&
       manualMock &&
       manualMock !== this._isCurrentlyExecutingManualMock &&
@@ -363,6 +365,10 @@ class Runtime {
     return this.requireModule(from, to, {isInternalModule: true});
   }
 
+  requireActual(from: Path, moduleName: string) {
+    return this.requireModule(from, moduleName, undefined, true);
+  }
+
   requireMock(from: Path, moduleName: string) {
     const moduleID = this._resolver.getModuleID(
       this._virtualMocks,
@@ -841,7 +847,7 @@ class Runtime {
         : this.requireModuleOrMock.bind(this, from.filename);
     moduleRequire.cache = Object.create(null);
     moduleRequire.extensions = Object.create(null);
-    moduleRequire.requireActual = this.requireModule.bind(this, from.filename);
+    moduleRequire.requireActual = this.requireActual.bind(this, from.filename);
     moduleRequire.requireMock = this.requireMock.bind(this, from.filename);
     moduleRequire.resolve = (moduleName, options) =>
       this._requireResolve(from.filename, moduleName, options);