diff --git a/CHANGELOG.md b/CHANGELOG.md
index 72b2a46da94f..b1d28937ce77 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -5,6 +5,7 @@
 - `[jest-config]` Add missing options to the `defaults` object ([#6428](https://github.com/facebook/jest/pull/6428))
 - `[expect]` Using symbolic property names in arrays no longer causes the `toEqual` matcher to fail ([#6391](https://github.com/facebook/jest/pull/6391))
 - `[expect]` `toEqual` no longer tries to compare non-enumerable symbolic properties, to be consistent with non-symbolic properties. ([#6398](https://github.com/facebook/jest/pull/6398))
+- `[jest-mock]` Fix `MockNativeMethods` access in react-native `jest.mock()` ([#6505](https://github.com/facebook/jest/pull/6505))
 
 ### Chore & Maintenance
 
diff --git a/e2e/babel-plugin-jest-hoist/__test_modules__/f.js b/e2e/babel-plugin-jest-hoist/__test_modules__/f.js
new file mode 100644
index 000000000000..46b073c7400c
--- /dev/null
+++ b/e2e/babel-plugin-jest-hoist/__test_modules__/f.js
@@ -0,0 +1,8 @@
+/**
+ * Copyright (c) 2014-present, Facebook, Inc. All rights reserved.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ */
+
+export default () => 'unmocked';
diff --git a/e2e/babel-plugin-jest-hoist/__tests__/integration.test.js b/e2e/babel-plugin-jest-hoist/__tests__/integration.test.js
index 2d09b1122a70..c825984639b3 100644
--- a/e2e/babel-plugin-jest-hoist/__tests__/integration.test.js
+++ b/e2e/babel-plugin-jest-hoist/__tests__/integration.test.js
@@ -61,6 +61,10 @@ jest.dontMock('../__test_modules__/Mocked');
 const myObject = {mock: () => {}};
 myObject.mock('apple', 27);
 
+// Variable names prefixed with `mock` (ignore case) should not throw as out-of-scope
+const MockMethods = () => {};
+jest.mock('../__test_modules__/f', () => MockMethods);
+
 describe('babel-plugin-jest-hoist', () => {
   it('does not throw during transform', () => {
     const object = {};
diff --git a/packages/babel-plugin-jest-hoist/src/index.js b/packages/babel-plugin-jest-hoist/src/index.js
index 5ace55013709..ba375a54cfd7 100644
--- a/packages/babel-plugin-jest-hoist/src/index.js
+++ b/packages/babel-plugin-jest-hoist/src/index.js
@@ -110,7 +110,7 @@ FUNCTIONS.mock = args => {
       if (!found) {
         invariant(
           (scope.hasGlobal(name) && WHITELISTED_IDENTIFIERS[name]) ||
-            /^mock/.test(name) ||
+            /^mock/i.test(name) ||
             // Allow istanbul's coverage variable to pass.
             /^(?:__)?cov/.test(name),
           'The module factory of `jest.mock()` is not allowed to ' +
@@ -123,7 +123,7 @@ FUNCTIONS.mock = args => {
             '.\n' +
             'Note: This is a precaution to guard against uninitialized mock ' +
             'variables. If it is ensured that the mock is required lazily, ' +
-            'variable names prefixed with `mock` are permitted.',
+            'variable names prefixed with `mock` (case insensitive) are permitted.',
         );
       }
     }