diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 7d08edcf..6a016146 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -9,11 +9,11 @@ jobs:
       fail-fast: false
       max-parallel: 5
       matrix:
-        python-version: ['3.6', '3.7', '3.8', '3.9', '3.10']
+        python-version: ['3.7', '3.8', '3.9', '3.10']
 
     services:
       postgres:
-        image: postgres:10
+        image: postgres:12
         env:
           POSTGRES_USER: postgres
           POSTGRES_PASSWORD: postgres
diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index 36db6a6d..0295ad11 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -12,3 +12,9 @@ repos:
       - id: flake8
         args: ['--ignore=E402,E501,E731,W503']
         files: ^(model_utils|tests)/
+
+  - repo: https://github.com/asottile/pyupgrade
+    rev: v2.37.3
+    hooks:
+    -   id: pyupgrade
+        args: [--py37-plus]
diff --git a/CHANGES.rst b/CHANGES.rst
index ae2be54e..8f1cbaf8 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -8,6 +8,9 @@ Unreleased
 - Add Spanish translation
 - Add French translation
 - Drop Django 1.7 workaround from `select_subclasses()`
+- Drop support for `Django < 3.2`
+- Drop support for `Python 3.6`
+- Confirm support for `Django 4.1`
 
 4.2.0 (2021-10-11)
 ------------------
diff --git a/README.rst b/README.rst
index c07f1098..7516a000 100644
--- a/README.rst
+++ b/README.rst
@@ -20,7 +20,7 @@ django-model-utils
 
 Django model mixins and utilities.
 
-``django-model-utils`` supports `Django`_ 2.2+.
+``django-model-utils`` supports `Django`_ 3.2+.
 
 .. _Django: http://www.djangoproject.com/
 
diff --git a/docs/setup.rst b/docs/setup.rst
index 06d274c8..69c98407 100644
--- a/docs/setup.rst
+++ b/docs/setup.rst
@@ -17,7 +17,7 @@ modify your ``INSTALLED_APPS`` setting.
 Dependencies
 ============
 
-``django-model-utils`` supports `Django`_ 2.2, 3.1 and 3.2 (latest bugfix
-release in each series only) on Python 3.6+.
+``django-model-utils`` supports `Django`_ 3.2+ (latest bugfix
+release in each series only) on Python 3.7+.
 
 .. _Django: http://www.djangoproject.com/
diff --git a/model_utils/managers.py b/model_utils/managers.py
index 19b8d71d..75d3d98a 100644
--- a/model_utils/managers.py
+++ b/model_utils/managers.py
@@ -139,7 +139,7 @@ def _get_ancestors_path(self, model, levels=None):
         """
         if not issubclass(model, self.model):
             raise ValueError(
-                "{!r} is not a subclass of {!r}".format(model, self.model))
+                f"{model!r} is not a subclass of {self.model!r}")
 
         ancestry = []
         # should be a OneToOneField or None
@@ -308,7 +308,7 @@ def get_quoted_query(self, query):
 
         # Put additional quotes around string.
         params = [
-            '\'{}\''.format(p)
+            f'\'{p}\''
             if isinstance(p, str) else p
             for p in params
         ]
@@ -338,7 +338,7 @@ def join(self, qs=None):
                 if getattr(fk, 'related_model', None) == self.model
             ]
             fk = fk[0] if fk else None
-            model_set = '{}_set'.format(self.model.__name__.lower())
+            model_set = f'{self.model.__name__.lower()}_set'
             key = fk or getattr(qs.model, model_set, None)
 
             if not key:
diff --git a/setup.py b/setup.py
index 3798bdaf..2c6f855f 100644
--- a/setup.py
+++ b/setup.py
@@ -8,7 +8,7 @@ def long_desc(root_path):
     for filename in FILES:
         filepath = os.path.realpath(os.path.join(root_path, filename))
         if os.path.isfile(filepath):
-            with open(filepath, mode='r') as f:
+            with open(filepath) as f:
                 yield f.read()
 
 
@@ -29,7 +29,8 @@ def long_desc(root_path):
     maintainer='JazzBand',
     url='https://github.com/jazzband/django-model-utils',
     packages=find_packages(exclude=['tests*']),
-    install_requires=['Django>=2.2'],
+    python_requires=">=3.7",
+    install_requires=['Django>=3.2'],
     classifiers=[
         'Development Status :: 5 - Production/Stable',
         'Environment :: Web Environment',
@@ -38,16 +39,14 @@ def long_desc(root_path):
         'Operating System :: OS Independent',
         'Programming Language :: Python',
         'Programming Language :: Python :: 3',
-        'Programming Language :: Python :: 3.6',
         'Programming Language :: Python :: 3.7',
         'Programming Language :: Python :: 3.8',
         'Programming Language :: Python :: 3.9',
         'Programming Language :: Python :: 3.10',
         'Framework :: Django',
-        'Framework :: Django :: 2.2',
-        'Framework :: Django :: 3.1',
         'Framework :: Django :: 3.2',
         'Framework :: Django :: 4.0',
+        'Framework :: Django :: 4.1',
     ],
     zip_safe=False,
     package_data={
diff --git a/tests/models.py b/tests/models.py
index c789267e..d785e880 100644
--- a/tests/models.py
+++ b/tests/models.py
@@ -1,4 +1,3 @@
-import django
 from django.db import models
 from django.db.models import Manager
 from django.db.models.query_utils import DeferredAttribute
@@ -387,13 +386,9 @@ def __get__(self, obj, cls=None):
             return self
         if self.name in obj.get_deferred_fields():
             # This queries the database, and sets the value on the instance.
-            if django.VERSION < (3, 0):
-                DeferredAttribute(field_name=self.name).__get__(obj, cls)
-            else:
-                # Since Django 3.0, DeferredAttribute wants a field argument.
-                fields_map = {f.name: f for f in cls._meta.fields}
-                field = fields_map[self.name]
-                DeferredAttribute(field=field).__get__(obj, cls)
+            fields_map = {f.name: f for f in cls._meta.fields}
+            field = fields_map[self.name]
+            DeferredAttribute(field=field).__get__(obj, cls)
         return str(obj.__dict__[self.name])
 
     def __set__(self, obj, value):
diff --git a/tests/test_managers/test_join_manager.py b/tests/test_managers/test_join_manager.py
index 3b8a4c27..57c1c344 100644
--- a/tests/test_managers/test_join_manager.py
+++ b/tests/test_managers/test_join_manager.py
@@ -6,7 +6,7 @@
 class JoinManagerTest(TestCase):
     def setUp(self):
         for i in range(20):
-            BoxJoinModel.objects.create(name='name_{i}'.format(i=i))
+            BoxJoinModel.objects.create(name=f'name_{i}')
 
         JoinItemForeignKey.objects.create(
             weight=10, belonging=BoxJoinModel.objects.get(name='name_1')
diff --git a/tox.ini b/tox.ini
index 40a05566..5a3ab0fb 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,14 +1,12 @@
 [tox]
 envlist =
-    py{36,37,38,39}-dj{22,31}
-    py{36,37,38,39,310}-dj32
-    py{38,39,310}-dj{40,main}
+    py{37,38,39,310}-dj32
+    py{38,39,310}-dj{40,41,main}
     flake8
     isort
 
 [gh-actions]
 python =
-    3.6: py36
     3.7: py37
     3.8: py38, flake8, isort
     3.9: py39
@@ -18,10 +16,9 @@ python =
 deps =
     freezegun==0.3.12
     -rrequirements-test.txt
-    dj22: Django==2.2.*
-    dj31: Django==3.1.*
     dj32: Django==3.2.*
     dj40: Django==4.0.*
+    dj41: Django==4.1.*
     djmain: https://github.com/django/django/archive/main.tar.gz
 ignore_outcome =
     djmain: True