diff --git a/.github/workflows/update-dependencies.yml b/.github/workflows/update-dependencies.yml
index 7814fe46..3538afd4 100644
--- a/.github/workflows/update-dependencies.yml
+++ b/.github/workflows/update-dependencies.yml
@@ -8,6 +8,9 @@ on:
   schedule:
     - cron: '0 18 * * 0'  # "At 18:00 on Sunday."
 
+env:
+  FORCE_COLOR: '1'
+
 jobs:
   update-dependencies:
     name: Update dependencies
@@ -17,6 +20,8 @@ jobs:
     - uses: wntrblm/nox@2024.04.15
       with:
         python-versions: "3.12"
+    - name: "Install uv"
+      run: pipx install uv
     - name: "Setup bot user"
       run: |
         git config --global user.name "manylinux-bot[bot]"
@@ -30,13 +35,13 @@ jobs:
         app_id: ${{ secrets.MANYLINUX_BOT_APP_ID }}
         private_key: ${{ secrets.MANYLINUX_BOT_APP_PRIVATE_KEY }}
     - name: "Run update native dependencies"
-      run: nox --force-color --error-on-missing-interpreters -s update_native_dependencies
+      run: nox -s update_native_dependencies
       env:
         GITHUB_API_TOKEN: ${{ steps.generate-token.outputs.token || github.token }}
     - name: "Run update downloaded interpreters"
-      run: nox --force-color --error-on-missing-interpreters -s update_interpreters_download
+      run: nox -s update_interpreters_download
     - name: "Run update python dependencies"
-      run: nox --force-color --error-on-missing-interpreters -s update_python_dependencies
+      run: nox -s update_python_dependencies
     - name: Create Pull Request
       if: github.ref == 'refs/heads/main' && github.repository == 'pypa/manylinux'
       uses: peter-evans/create-pull-request@v5
diff --git a/README.rst b/README.rst
index 84e81456..1b98df98 100644
--- a/README.rst
+++ b/README.rst
@@ -210,7 +210,18 @@ All images currently contain:
 
 - Development packages for all the libraries that PEP 571/599 list. One should not assume the presence of any other development package.
 
-- The `auditwheel <https://pypi.python.org/pypi/auditwheel>`_ tool
+- The following development tools, installed via `pipx <https://pypi.org/p/pipx>`_ (which is also available):
+   - `auditwheel <https://pypi.org/p/auditwheel>`_
+   - `cmake <https://pypi.org/p/cmake>`_
+   - `patchelf <https://pypi.org/p/patchelf>`_
+   - `swig <https://pypi.org/p/swig>`_
+   - `uv <https://pypi.org/p/uv>`_ (not available on ``musllinux s390x`` and ``muslllinux powerpc64le`` yet due to Rust limitations)
+
+- All Python interpreters have the following packages pre-installed:
+  - `pip <https://pypi.org/p/pip>`_
+  - `build <https://pypi.org/p/build>`_
+  - `packaging <https://pypi.org/p/packaging>`_
+  - Before Python 3.12, `setuptools <https://pypi.org/p/setuptools>`_ and `wheel <https://pypi.org/p/wheel>`_ are also available. (Currently 3.12 too, but will be removed after 3.13 is released.)
 
 - The manylinux-interpreters tool which allows to list all available interpreters & install ones missing from the image
 
diff --git a/docker/build_scripts/finalize.sh b/docker/build_scripts/finalize.sh
index df050989..122b189d 100755
--- a/docker/build_scripts/finalize.sh
+++ b/docker/build_scripts/finalize.sh
@@ -79,7 +79,10 @@ pipx uninstall pip
 # install other tools with pipx
 for TOOL_PATH in $(find ${MY_DIR}/requirements-tools -type f); do
 	TOOL=$(basename ${TOOL_PATH})
-	pipx install --pip-args="--require-hashes -r ${TOOL_PATH} --only-binary" ${TOOL}
+    # uv doesn't provide musl s390x wheels due to Rust issues
+	if [[ "$TOOL" != "uv" || "$AUDITWHEEL_POLICY" != musllinux* || "$AUDITWHEEL_ARCH" != "s390x" ]]; then
+		pipx install --pip-args="--require-hashes -r ${TOOL_PATH} --only-binary" ${TOOL}
+	fi
 done
 
 # We do not need the precompiled .pyc and .pyo files.
diff --git a/docker/build_scripts/requirements-tools/uv b/docker/build_scripts/requirements-tools/uv
new file mode 100644
index 00000000..9dedf84b
--- /dev/null
+++ b/docker/build_scripts/requirements-tools/uv
@@ -0,0 +1,22 @@
+# This file was autogenerated by uv via the following command:
+#    nox -s update_python_dependencies
+uv==0.1.45 \
+    --hash=sha256:088af576fb0e0462cd5f718d03fb1a9f16ce5ae61fdb2a9d3ea938fc826cecc1 \
+    --hash=sha256:0f6cfe885f109bacc055edd5df2c837616ae2238b9324a9d37835a96b204ab2f \
+    --hash=sha256:110e0f45ddb2fe832ce50b0308be90e5439e0c02d3ffe042feeb3f759811f31f \
+    --hash=sha256:2ca2d5a5e06c5f71c7b213e14fa59129e63b77de3ffbcf84ecc98d647d73a821 \
+    --hash=sha256:346aa2d0a4ad3c0c3f7852c1edf5e5a8e5d2ef34c7474e9089877291c2da979c \
+    --hash=sha256:40fab956bc7af50dfa4bda14e5871528f57603eb9bf8595eb3144aace0ed8c47 \
+    --hash=sha256:4e5d55f0f8b6ae416c72d78106e224c8e8338356da21ddebecc7b1723de80924 \
+    --hash=sha256:68718add6ee2cef2816f9bf8a1dbf2d8cf63d98ddf45840f340029f65a49fd89 \
+    --hash=sha256:7fdb235aaf420fa8ac9009999b1654a23540f03e25c35094543c2f48d7c41aef \
+    --hash=sha256:87e77d25e8f358c0d5de1983497ee4cf4cea8fc73373d1ef1063533352db2f89 \
+    --hash=sha256:8e2eeea4eec0e09f7d67378152428b5308dba8b33990d045d7a31d19bf18ca1f \
+    --hash=sha256:90b68c80dddebeca69b26a2af1e2e683804bcf2b5f22d107af03d9156d6218c6 \
+    --hash=sha256:a39141e179fea043151a165c9155031e7976b0e4b076c0c33a45b58a420134e0 \
+    --hash=sha256:a601eed14d484d36d421e4208911a56aaf758ea6c385ef8edf8ad9f8ead57ce1 \
+    --hash=sha256:b94180009264f3f7ee74250f8e4f99c8cb0cb3633e3a9c9c66cdef3eb69be575 \
+    --hash=sha256:cd7f2f64fdded940342dc37234c11ae3508222c3c9b6b0eac5879dcd586010fa \
+    --hash=sha256:ddb93620c9e01fa83573c2648df4bee3fa548ca940de51c8a2c3566a23a0c776 \
+    --hash=sha256:de81501c0b03160d0944906d1a713f108258360e20c58385974acb7253b56166
+    # via -r .nox/update_python_dependencies/tmp/uv.in
diff --git a/noxfile.py b/noxfile.py
index b0e4c0be..8e136ff8 100644
--- a/noxfile.py
+++ b/noxfile.py
@@ -4,9 +4,13 @@
 
 import nox
 
+nox.needs_version = ">=2024.4.15"
+nox.options.default_venv_backend = "uv|virtualenv"
+
 
 @nox.session
 def update_python_dependencies(session):
+    "Update the base and per-python dependencies lockfiles"
     if getattr(session.virtualenv, "venv_backend", "") != "uv":
         session.install("uv>=0.1.23")
 
@@ -60,11 +64,17 @@ def update_python_dependencies(session):
 
 @nox.session(python="3.11", reuse_venv=True)
 def update_native_dependencies(session):
-    session.install("lastversion>=3.5.0", "packaging", "requests")
-    session.run("python", "tools/update_native_dependencies.py", *session.posargs)
+    "Update the native dependencies"
+    script = "tools/update_native_dependencies.py"
+    deps = nox.project.load_toml(script)["dependencies"]
+    session.install(*deps)
+    session.run("python", script, *session.posargs)
 
 
 @nox.session(python="3.11", reuse_venv=True)
 def update_interpreters_download(session):
-    session.install("packaging", "requests")
-    session.run("python", "tools/update_interpreters_download.py", *session.posargs)
+    "Update all the Python interpreters"
+    script = "tools/update_interpreters_download.py"
+    deps = nox.project.load_toml(script)["dependencies"]
+    session.install(*deps)
+    session.run("python", script, *session.posargs)
diff --git a/requirements-tools.in b/requirements-tools.in
index 5a11bef3..cb04eb9c 100644
--- a/requirements-tools.in
+++ b/requirements-tools.in
@@ -2,3 +2,4 @@ auditwheel
 cmake
 patchelf
 swig
+uv
diff --git a/tools/update_interpreters_download.py b/tools/update_interpreters_download.py
index 094653e4..5e04662d 100644
--- a/tools/update_interpreters_download.py
+++ b/tools/update_interpreters_download.py
@@ -1,3 +1,9 @@
+#!/usr/bin/env python
+
+# /// script
+# dependencies = ["packaging", "requests"]
+# ///
+
 from __future__ import annotations
 
 import argparse
diff --git a/tools/update_native_dependencies.py b/tools/update_native_dependencies.py
index 32fe7e2f..71b0d2c5 100644
--- a/tools/update_native_dependencies.py
+++ b/tools/update_native_dependencies.py
@@ -1,3 +1,9 @@
+#!/usr/bin/env python
+
+# /// script
+# dependencies = ["lastversion>=3.5.0", "packaging", "requests"]
+# ///
+
 import argparse
 import hashlib
 import re