diff --git a/extensions/netty/deployment/src/main/java/io/quarkus/netty/deployment/NettyProcessor.java b/extensions/netty/deployment/src/main/java/io/quarkus/netty/deployment/NettyProcessor.java
index 5de637d124c8c..8d0f294af25fe 100644
--- a/extensions/netty/deployment/src/main/java/io/quarkus/netty/deployment/NettyProcessor.java
+++ b/extensions/netty/deployment/src/main/java/io/quarkus/netty/deployment/NettyProcessor.java
@@ -162,8 +162,28 @@ NativeImageConfigBuildItem build(
             log.debug("Not registering Netty native kqueue classes as they were not found");
         }
 
-        builder.addRuntimeReinitializedClass("io.netty.util.internal.PlatformDependent");
-        builder.addRuntimeReinitializedClass("io.netty.util.internal.PlatformDependent0");
+        builder.addRuntimeReinitializedClass("io.netty.util.internal.PlatformDependent")
+                .addRuntimeReinitializedClass("io.netty.util.internal.PlatformDependent0")
+                .addRuntimeReinitializedClass("io.netty.buffer.PooledByteBufAllocator");
+
+        if (QuarkusClassLoader.isClassPresentAtRuntime("io.netty.buffer.UnpooledByteBufAllocator")) {
+            builder.addRuntimeReinitializedClass("io.netty.buffer.UnpooledByteBufAllocator")
+                    .addRuntimeReinitializedClass("io.netty.buffer.Unpooled")
+                    .addRuntimeReinitializedClass("io.vertx.core.http.impl.Http1xServerResponse")
+                    .addRuntimeReinitializedClass("io.netty.handler.codec.http.HttpObjectAggregator")
+                    .addRuntimeReinitializedClass("io.netty.handler.codec.ReplayingDecoderByteBuf")
+                    .addRuntimeReinitializedClass("io.vertx.core.parsetools.impl.RecordParserImpl");
+
+            if (QuarkusClassLoader.isClassPresentAtRuntime("io.vertx.ext.web.client.impl.MultipartFormUpload")) {
+                builder.addRuntimeReinitializedClass("io.vertx.ext.web.client.impl.MultipartFormUpload");
+            }
+
+            if (QuarkusClassLoader
+                    .isClassPresentAtRuntime("org.jboss.resteasy.reactive.client.impl.multipart.QuarkusMultipartFormUpload")) {
+                builder.addRuntimeReinitializedClass(
+                        "org.jboss.resteasy.reactive.client.impl.multipart.QuarkusMultipartFormUpload");
+            }
+        }
 
         return builder //TODO: make configurable
                 .build();