diff --git a/proto-google-cloud-spanner-admin-database-v1/clirr-ignored-differences.xml b/proto-google-cloud-spanner-admin-database-v1/clirr-ignored-differences.xml
index c1e8fc9b84..3799fb341a 100644
--- a/proto-google-cloud-spanner-admin-database-v1/clirr-ignored-differences.xml
+++ b/proto-google-cloud-spanner-admin-database-v1/clirr-ignored-differences.xml
@@ -16,4 +16,66 @@
     <className>com/google/spanner/admin/database/v1/*OrBuilder</className>
     <method>boolean has*(*)</method>
   </difference>
+
+  <!-- The following 7006 exemptions are related to Protobuf 4.27.4+ runtime upgrade -->
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/database/v1/**</className>
+    <method>* getDefaultInstanceForType()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/database/v1/**</className>
+    <method>* addRepeatedField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/database/v1/**</className>
+    <method>* clear()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/database/v1/**</className>
+    <method>* clearField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/database/v1/**</className>
+    <method>* clearOneof(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/database/v1/**</className>
+    <method>* clone()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/database/v1/**</className>
+    <method>* mergeUnknownFields(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/database/v1/**</className>
+    <method>* setField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/database/v1/**</className>
+    <method>* setRepeatedField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/database/v1/**</className>
+    <method>* setUnknownFields(*)</method>
+    <to>**</to>
+  </difference>
 </differences>
diff --git a/proto-google-cloud-spanner-admin-instance-v1/clirr-ignored-differences.xml b/proto-google-cloud-spanner-admin-instance-v1/clirr-ignored-differences.xml
index b24b9e881c..fa9181b755 100644
--- a/proto-google-cloud-spanner-admin-instance-v1/clirr-ignored-differences.xml
+++ b/proto-google-cloud-spanner-admin-instance-v1/clirr-ignored-differences.xml
@@ -16,4 +16,66 @@
     <className>com/google/spanner/admin/instance/v1/*OrBuilder</className>
     <method>boolean has*(*)</method>
   </difference>
+
+  <!-- The following 7006 exemptions are related to Protobuf 4.27.4+ runtime upgrade -->
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/instance/v1/**</className>
+    <method>* getDefaultInstanceForType()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/instance/v1/**</className>
+    <method>* addRepeatedField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/instance/v1/**</className>
+    <method>* clear()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/instance/v1/**</className>
+    <method>* clearField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/instance/v1/**</className>
+    <method>* clearOneof(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/instance/v1/**</className>
+    <method>* clone()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/instance/v1/**</className>
+    <method>* mergeUnknownFields(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/instance/v1/**</className>
+    <method>* setField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/instance/v1/**</className>
+    <method>* setRepeatedField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/admin/instance/v1/**</className>
+    <method>* setUnknownFields(*)</method>
+    <to>**</to>
+  </difference>
 </differences>
diff --git a/proto-google-cloud-spanner-executor-v1/clirr-ignored-differences.xml b/proto-google-cloud-spanner-executor-v1/clirr-ignored-differences.xml
index cfd1e566a2..c8787595be 100644
--- a/proto-google-cloud-spanner-executor-v1/clirr-ignored-differences.xml
+++ b/proto-google-cloud-spanner-executor-v1/clirr-ignored-differences.xml
@@ -36,4 +36,66 @@
     <differenceType>8001</differenceType>
     <className>com/google/spanner/executor/v1/SpannerExecutorProxyGrpc$SpannerExecutorProxyStub</className>
   </difference>
+
+  <!-- The following 7006 exemptions are related to Protobuf 4.27.4+ runtime upgrade -->
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/executor/v1/**</className>
+    <method>* getDefaultInstanceForType()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/executor/v1/**</className>
+    <method>* addRepeatedField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/executor/v1/**</className>
+    <method>* clear()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/executor/v1/**</className>
+    <method>* clearField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/executor/v1/**</className>
+    <method>* clearOneof(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/executor/v1/**</className>
+    <method>* clone()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/executor/v1/**</className>
+    <method>* mergeUnknownFields(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/executor/v1/**</className>
+    <method>* setField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/executor/v1/**</className>
+    <method>* setRepeatedField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/executor/v1/**</className>
+    <method>* setUnknownFields(*)</method>
+    <to>**</to>
+  </difference>
 </differences>
diff --git a/proto-google-cloud-spanner-v1/clirr-ignored-differences.xml b/proto-google-cloud-spanner-v1/clirr-ignored-differences.xml
index f9ff243533..89fd05b2e3 100644
--- a/proto-google-cloud-spanner-v1/clirr-ignored-differences.xml
+++ b/proto-google-cloud-spanner-v1/clirr-ignored-differences.xml
@@ -16,4 +16,66 @@
     <className>com/google/spanner/v1/*OrBuilder</className>
     <method>boolean has*(*)</method>
   </difference>
+
+  <!-- The following 7006 exemptions are related to Protobuf 4.27.4+ runtime upgrade -->
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/v1/**</className>
+    <method>* getDefaultInstanceForType()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/v1/**</className>
+    <method>* addRepeatedField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/v1/**</className>
+    <method>* clear()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/v1/**</className>
+    <method>* clearField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/v1/**</className>
+    <method>* clearOneof(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/v1/**</className>
+    <method>* clone()</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/v1/**</className>
+    <method>* mergeUnknownFields(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/v1/**</className>
+    <method>* setField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/v1/**</className>
+    <method>* setRepeatedField(*)</method>
+    <to>**</to>
+  </difference>
+  <difference>
+    <differenceType>7006</differenceType>
+    <className>com/google/spanner/v1/**</className>
+    <method>* setUnknownFields(*)</method>
+    <to>**</to>
+  </difference>
 </differences>