diff --git a/packages/google-cloud-python-speech/noxfile.py b/packages/google-cloud-python-speech/noxfile.py
index 92da31f8c16d..bd20103275bf 100644
--- a/packages/google-cloud-python-speech/noxfile.py
+++ b/packages/google-cloud-python-speech/noxfile.py
@@ -324,3 +324,67 @@ def docfx(session):
         os.path.join("docs", ""),
         os.path.join("docs", "_build", "html", ""),
     )
+
+
+@nox.session(python=SYSTEM_TEST_PYTHON_VERSIONS)
+def prerelease_deps(session):
+    """Run all tests with prerelease versions of dependencies installed."""
+
+    prerel_deps = [
+        "protobuf",
+        "googleapis-common-protos",
+        "google-auth",
+        "grpcio",
+        "grpcio-status",
+        "google-api-core",
+        "proto-plus",
+        # dependencies of google-auth
+        "cryptography",
+        "pyasn1",
+    ]
+
+    for dep in prerel_deps:
+        session.install("--pre", "--no-deps", "--upgrade", dep)
+
+    # Remaining dependencies
+    other_deps = ["requests"]
+    session.install(*other_deps)
+
+    session.install(*UNIT_TEST_STANDARD_DEPENDENCIES)
+    session.install(*SYSTEM_TEST_STANDARD_DEPENDENCIES)
+
+    # Because we test minimum dependency versions on the minimum Python
+    # version, the first version we test with in the unit tests sessions has a
+    # constraints file containing all dependencies and extras.
+    with open(
+        CURRENT_DIRECTORY
+        / "testing"
+        / f"constraints-{UNIT_TEST_PYTHON_VERSIONS[0]}.txt",
+        encoding="utf-8",
+    ) as constraints_file:
+        constraints_text = constraints_file.read()
+
+    # Ignore leading whitespace and comment lines.
+    deps = [
+        match.group(1)
+        for match in re.finditer(
+            r"^\s*(\S+)(?===\S+)", constraints_text, flags=re.MULTILINE
+        )
+    ]
+
+    # Don't overwrite prerelease packages.
+    deps = [dep for dep in deps if dep not in prerel_deps]
+    # We use --no-deps to ensure that pre-release versions aren't overwritten
+    # by the version ranges in setup.py.
+    session.install(*deps)
+    session.install("--no-deps", "-e", ".[all]")
+
+    # Print out prerelease package versions
+    session.run(
+        "python", "-c", "import google.protobuf; print(google.protobuf.__version__)"
+    )
+    session.run("python", "-c", "import grpc; print(grpc.__version__)")
+
+    session.run("py.test", "tests/unit")
+    session.run("py.test", "tests/system")
+    session.run("py.test", "samples/snippets")