diff --git a/packages/google-cloud-apigee-connect/setup.py b/packages/google-cloud-apigee-connect/setup.py
index 56af63d8d644..122d4e340cc2 100644
--- a/packages/google-cloud-apigee-connect/setup.py
+++ b/packages/google-cloud-apigee-connect/setup.py
@@ -26,8 +26,8 @@
 url = "https://github.com/googleapis/python-apigee-connect"
 dependencies = [
     "google-api-core[grpc] >= 1.32.0, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.*,!=2.4.*,!=2.5.*,!=2.6.*,!=2.7.*",
-    "proto-plus >= 1.15.0, <2.0.0dev",
-    "protobuf >= 3.19.0, <4.0.0dev",
+    "proto-plus >= 1.22.0, <2.0.0dev",
+    "protobuf >= 3.19.0, <5.0.0dev",
 ]
 
 package_root = os.path.abspath(os.path.dirname(__file__))
diff --git a/packages/google-cloud-apigee-connect/testing/constraints-3.7.txt b/packages/google-cloud-apigee-connect/testing/constraints-3.7.txt
index 317c02ddaa88..51901fbcf804 100644
--- a/packages/google-cloud-apigee-connect/testing/constraints-3.7.txt
+++ b/packages/google-cloud-apigee-connect/testing/constraints-3.7.txt
@@ -6,5 +6,5 @@
 # e.g., if setup.py has "foo >= 1.14.0, < 2.0.0dev",
 # Then this file should have foo==1.14.0
 google-api-core==1.32.0
-proto-plus==1.15.0
+proto-plus==1.22.0
 protobuf==3.19.0