diff --git a/CHANGELOG.md b/CHANGELOG.md
index 7796dd407..b42238dff 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,9 @@
 
 ## 1.28.1
 
+### Improvements
+- When writing zarr sinks through the converter, use jpeg compression for lossy data ([#1501](../../pull/1501))
+
 ### Changes
 - Improve algorithm sweep example options ([#1498](../../pull/1498))
 
diff --git a/sources/zarr/large_image_source_zarr/__init__.py b/sources/zarr/large_image_source_zarr/__init__.py
index fb22d24a0..18f53e68d 100644
--- a/sources/zarr/large_image_source_zarr/__init__.py
+++ b/sources/zarr/large_image_source_zarr/__init__.py
@@ -819,7 +819,10 @@ def write(
             from large_image_converter import convert
 
             attrs_path = Path(source._tempdir.name) / '.zattrs'
-            convert(str(attrs_path), path, overwrite=overwriteAllowed)
+            params = {}
+            if lossy and self.dtype == np.uint8:
+                params['compression'] = 'jpeg'
+            convert(str(attrs_path), path, overwrite=overwriteAllowed, **params)
 
 
 def open(*args, **kwargs):