diff --git a/CHANGELOG.md b/CHANGELOG.md
index 79d0309259..9af353b393 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -57,6 +57,7 @@ Bottom level categories:
 ### Bug Fixes
 
 - Fix order of arguments to glPolygonOffset by @komadori in [#3783](https://github.com/gfx-rs/wgpu/pull/3783).
+- Fix missing 4X MSAA support on some OpenGL backends. By @emilk in [#3780](https://github.com/gfx-rs/wgpu/pull/3780)
 
 #### General
 
diff --git a/wgpu-hal/src/gles/adapter.rs b/wgpu-hal/src/gles/adapter.rs
index b14857ae22..dac13f27df 100644
--- a/wgpu-hal/src/gles/adapter.rs
+++ b/wgpu-hal/src/gles/adapter.rs
@@ -713,10 +713,12 @@ impl crate::Adapter<super::Api> for super::Adapter {
                     | Tfc::MULTISAMPLE_X16
             } else if max_samples >= 8 {
                 Tfc::MULTISAMPLE_X2 | Tfc::MULTISAMPLE_X4 | Tfc::MULTISAMPLE_X8
-            } else if max_samples >= 4 {
-                Tfc::MULTISAMPLE_X2 | Tfc::MULTISAMPLE_X4
             } else {
-                Tfc::MULTISAMPLE_X2
+                // The lowest supported level in GLE3.0/WebGL2 is 4X
+                // (see GL_MAX_SAMPLES in https://registry.khronos.org/OpenGL-Refpages/es3.0/html/glGet.xhtml).
+                // On some platforms, like iOS Safari, `get_parameter_i32(MAX_SAMPLES)` returns 0,
+                // so we always fall back to supporting 4x here.
+                Tfc::MULTISAMPLE_X2 | Tfc::MULTISAMPLE_X4
             }
         };