diff --git a/sentry_sdk/integrations/aiohttp.py b/sentry_sdk/integrations/aiohttp.py
index a447b67f38..6a738f3af0 100644
--- a/sentry_sdk/integrations/aiohttp.py
+++ b/sentry_sdk/integrations/aiohttp.py
@@ -139,7 +139,17 @@ async def sentry_app_handle(self, request, *args, **kwargs):
                             # have no way to tell. Do not set span status.
                             reraise(*_capture_exception())
 
-                        transaction.set_http_status(response.status)
+                        try:
+                            # A valid response handler will return a valid response with a status. But, if the handler
+                            # returns an invalid response (e.g. None), the line below will raise an AttributeError.
+                            # Even though this is likely invalid, we need to handle this case to ensure we don't break
+                            # the application.
+                            response_status = response.status
+                        except AttributeError:
+                            pass
+                        else:
+                            transaction.set_http_status(response_status)
+
                         return response
 
         Application._handle = sentry_app_handle
diff --git a/tests/integrations/aiohttp/test_aiohttp.py b/tests/integrations/aiohttp/test_aiohttp.py
index 43e3bec546..be372b6643 100644
--- a/tests/integrations/aiohttp/test_aiohttp.py
+++ b/tests/integrations/aiohttp/test_aiohttp.py
@@ -596,3 +596,24 @@ async def hello(request):
     (event,) = events
     assert event["contexts"]["trace"]["origin"] == "auto.http.aiohttp"
     assert event["spans"][0]["origin"] == "auto.http.aiohttp"
+
+
+@pytest.mark.asyncio
+@pytest.mark.parametrize("invalid_response", (None, "invalid"))
+async def test_invalid_response(
+    sentry_init, aiohttp_client, capture_events, invalid_response
+):
+    sentry_init(integrations=[AioHttpIntegration()])
+
+    async def handler(_):
+        return invalid_response
+
+    app = web.Application()
+    app.router.add_get("/", handler)
+
+    client = await aiohttp_client(app)
+
+    # Invalid response should result on a ServerDisconnectedError in the client side, not an internal server error.
+    # Important to note that the ServerDisconnectedError indicates we have no error server-side.
+    with pytest.raises(ServerDisconnectedError):
+        await client.get("/")