diff --git a/packages/core/src/transports/multiplexed.ts b/packages/core/src/transports/multiplexed.ts
index c7045f4b2686..a496a8adcd6f 100644
--- a/packages/core/src/transports/multiplexed.ts
+++ b/packages/core/src/transports/multiplexed.ts
@@ -24,9 +24,15 @@ interface MatchParam {
   getEvent(types?: EnvelopeItemType[]): Event | undefined;
 }
 
-type Matcher = (param: MatchParam) => string[];
+type RouteTo = { dsn: string; release: string };
+type Matcher = (param: MatchParam) => (string | RouteTo)[];
 
-function eventFromEnvelope(env: Envelope, types: EnvelopeItemType[]): Event | undefined {
+/**
+ * Gets an event from an envelope.
+ *
+ * This is only exported for use in the tests
+ */
+export function eventFromEnvelope(env: Envelope, types: EnvelopeItemType[]): Event | undefined {
   let event: Event | undefined;
 
   forEachEnvelopeItem(env, (item, type) => {
@@ -40,6 +46,30 @@ function eventFromEnvelope(env: Envelope, types: EnvelopeItemType[]): Event | un
   return event;
 }
 
+/**
+ * Creates a transport that overrides the release on all events.
+ */
+function makeOverrideReleaseTransport<TO extends BaseTransportOptions>(
+  createTransport: (options: TO) => Transport,
+  release: string,
+): (options: TO) => Transport {
+  return options => {
+    const transport = createTransport(options);
+
+    return {
+      send: async (envelope: Envelope): Promise<void | TransportMakeRequestResponse> => {
+        const event = eventFromEnvelope(envelope, ['event', 'transaction', 'profile', 'replay_event']);
+
+        if (event) {
+          event.release = release;
+        }
+        return transport.send(envelope);
+      },
+      flush: timeout => transport.flush(timeout),
+    };
+  };
+}
+
 /**
  * Creates a transport that can send events to different DSNs depending on the envelope contents.
  */
@@ -51,17 +81,24 @@ export function makeMultiplexedTransport<TO extends BaseTransportOptions>(
     const fallbackTransport = createTransport(options);
     const otherTransports: Record<string, Transport> = {};
 
-    function getTransport(dsn: string): Transport | undefined {
-      if (!otherTransports[dsn]) {
+    function getTransport(dsn: string, release: string | undefined): Transport | undefined {
+      // We create a transport for every unique dsn/release combination as there may be code from multiple releases in
+      // use at the same time
+      const key = release ? `${dsn}:${release}` : dsn;
+
+      if (!otherTransports[key]) {
         const validatedDsn = dsnFromString(dsn);
         if (!validatedDsn) {
           return undefined;
         }
         const url = getEnvelopeEndpointWithUrlEncodedAuth(validatedDsn);
-        otherTransports[dsn] = createTransport({ ...options, url });
+
+        otherTransports[key] = release
+          ? makeOverrideReleaseTransport(createTransport, release)({ ...options, url })
+          : createTransport({ ...options, url });
       }
 
-      return otherTransports[dsn];
+      return otherTransports[key];
     }
 
     async function send(envelope: Envelope): Promise<void | TransportMakeRequestResponse> {
@@ -71,7 +108,13 @@ export function makeMultiplexedTransport<TO extends BaseTransportOptions>(
       }
 
       const transports = matcher({ envelope, getEvent })
-        .map(dsn => getTransport(dsn))
+        .map(result => {
+          if (typeof result === 'string') {
+            return getTransport(result, undefined);
+          } else {
+            return getTransport(result.dsn, result.release);
+          }
+        })
         .filter((t): t is Transport => !!t);
 
       // If we have no transports to send to, use the fallback transport
diff --git a/packages/core/test/lib/transports/multiplexed.test.ts b/packages/core/test/lib/transports/multiplexed.test.ts
index 2d2dcb5ce46d..446d185f9301 100644
--- a/packages/core/test/lib/transports/multiplexed.test.ts
+++ b/packages/core/test/lib/transports/multiplexed.test.ts
@@ -6,10 +6,11 @@ import type {
   TransactionEvent,
   Transport,
 } from '@sentry/types';
-import { createClientReportEnvelope, createEnvelope, dsnFromString } from '@sentry/utils';
-import { TextEncoder } from 'util';
+import { createClientReportEnvelope, createEnvelope, dsnFromString, parseEnvelope } from '@sentry/utils';
+import { TextDecoder, TextEncoder } from 'util';
 
 import { createTransport, getEnvelopeEndpointWithUrlEncodedAuth, makeMultiplexedTransport } from '../../../src';
+import { eventFromEnvelope } from '../../../src/transports/multiplexed';
 
 const DSN1 = 'https://1234@5678.ingest.sentry.io/4321';
 const DSN1_URL = getEnvelopeEndpointWithUrlEncodedAuth(dsnFromString(DSN1)!);
@@ -47,7 +48,7 @@ const CLIENT_REPORT_ENVELOPE = createClientReportEnvelope(
   123456,
 );
 
-type Assertion = (url: string, body: string | Uint8Array) => void;
+type Assertion = (url: string, release: string | undefined, body: string | Uint8Array) => void;
 
 const createTestTransport = (...assertions: Assertion[]): ((options: BaseTransportOptions) => Transport) => {
   return (options: BaseTransportOptions) =>
@@ -57,7 +58,10 @@ const createTestTransport = (...assertions: Assertion[]): ((options: BaseTranspo
         if (!assertion) {
           throw new Error('No assertion left');
         }
-        assertion(options.url, request.body);
+
+        const event = eventFromEnvelope(parseEnvelope(request.body, new TextEncoder(), new TextDecoder()), ['event']);
+
+        assertion(options.url, event?.release, request.body);
         resolve({ statusCode: 200 });
       });
     });
@@ -111,6 +115,21 @@ describe('makeMultiplexedTransport', () => {
     await transport.send(ERROR_ENVELOPE);
   });
 
+  it('DSN and release can be overridden via match callback', async () => {
+    expect.assertions(2);
+
+    const makeTransport = makeMultiplexedTransport(
+      createTestTransport((url, release) => {
+        expect(url).toBe(DSN2_URL);
+        expect(release).toBe('something@1.0.0');
+      }),
+      () => [{ dsn: DSN2, release: 'something@1.0.0' }],
+    );
+
+    const transport = makeTransport({ url: DSN1_URL, ...transportOptions });
+    await transport.send(ERROR_ENVELOPE);
+  });
+
   it('match callback can return multiple DSNs', async () => {
     expect.assertions(2);