diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt
index 8a0c88f805..04f853bdbf 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt
@@ -24,7 +24,7 @@ requests==2.32.3
 tomli==2.0.1
 typing_extensions==4.12.2
 urllib3==2.2.2
-Werkzeug==3.0.3
+Werkzeug==3.0.6
 wrapt==1.16.0
 yarl==1.9.4
 zipp==3.19.2
diff --git a/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt
index 5253cf3bba..aa5f89859f 100644
--- a/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt
@@ -29,7 +29,7 @@ six==1.16.0
 tomli==2.0.1
 typing_extensions==4.12.2
 urllib3==1.26.19
-Werkzeug==3.0.3
+Werkzeug==3.0.6
 wrapt==1.16.0
 xmltodict==0.13.0
 zipp==3.19.2
diff --git a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt
index 59edf6f540..d7bf77e315 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt
+++ b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt
@@ -13,7 +13,7 @@ py-cpuinfo==9.0.0
 pytest==7.4.4
 tomli==2.0.1
 typing_extensions==4.12.2
-Werkzeug==3.0.3
+Werkzeug==3.0.6
 wrapt==1.16.0
 zipp==3.19.2
 -e opentelemetry-instrumentation
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
index 97815133f8..157b9b6040 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
@@ -15,7 +15,7 @@ translationstring==1.4
 typing_extensions==4.12.2
 venusian==3.1.0
 WebOb==1.8.8
-Werkzeug==3.0.3
+Werkzeug==3.0.6
 wrapt==1.16.0
 zipp==3.19.2
 zope.deprecation==5.0
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
index 2a16e05476..2df7df38ec 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
@@ -20,7 +20,7 @@ tomli==2.0.1
 tornado==6.4.2
 typing_extensions==4.12.2
 urllib3==2.2.2
-Werkzeug==3.0.3
+Werkzeug==3.0.6
 wrapt==1.16.0
 zipp==3.19.2
 -e opentelemetry-instrumentation