diff --git a/package.json b/package.json
index c3aa7eb0b9270..3c72f0d80a83e 100644
--- a/package.json
+++ b/package.json
@@ -77,6 +77,7 @@
     "minimist": "^1.2.3",
     "mkdirp": "^0.5.1",
     "ncp": "^2.0.0",
+    "@actuallyworks/node-fetch": "^2.6.0",
     "pacote": "^10.3.0",
     "prettier": "1.19.1",
     "prop-types": "^15.6.2",
diff --git a/packages/react-reconciler/src/ReactFiberHooks.new.js b/packages/react-reconciler/src/ReactFiberHooks.new.js
index 2e399e7897794..6b67e7497b181 100644
--- a/packages/react-reconciler/src/ReactFiberHooks.new.js
+++ b/packages/react-reconciler/src/ReactFiberHooks.new.js
@@ -770,6 +770,8 @@ if (enableUseMemoCacheHook) {
   };
 }
 
+function noop(): void {}
+
 function use<T>(usable: Usable<T>): T {
   if (usable !== null && typeof usable === 'object') {
     // $FlowFixMe[method-unbinding]
@@ -795,6 +797,11 @@ function use<T>(usable: Usable<T>): T {
             index,
           );
           if (prevThenableAtIndex !== null) {
+            if (thenable !== prevThenableAtIndex) {
+              // Avoid an unhandled rejection errors for the Promises that we'll
+              // intentionally ignore.
+              thenable.then(noop, noop);
+            }
             switch (prevThenableAtIndex.status) {
               case 'fulfilled': {
                 const fulfilledValue: T = prevThenableAtIndex.value;
diff --git a/packages/react-reconciler/src/ReactFiberHooks.old.js b/packages/react-reconciler/src/ReactFiberHooks.old.js
index 7c4a705517346..5a4c86f0c0c1e 100644
--- a/packages/react-reconciler/src/ReactFiberHooks.old.js
+++ b/packages/react-reconciler/src/ReactFiberHooks.old.js
@@ -770,6 +770,8 @@ if (enableUseMemoCacheHook) {
   };
 }
 
+function noop(): void {}
+
 function use<T>(usable: Usable<T>): T {
   if (usable !== null && typeof usable === 'object') {
     // $FlowFixMe[method-unbinding]
@@ -795,6 +797,11 @@ function use<T>(usable: Usable<T>): T {
             index,
           );
           if (prevThenableAtIndex !== null) {
+            if (thenable !== prevThenableAtIndex) {
+              // Avoid an unhandled rejection errors for the Promises that we'll
+              // intentionally ignore.
+              thenable.then(noop, noop);
+            }
             switch (prevThenableAtIndex.status) {
               case 'fulfilled': {
                 const fulfilledValue: T = prevThenableAtIndex.value;
diff --git a/packages/react-server/src/ReactFizzHooks.js b/packages/react-server/src/ReactFizzHooks.js
index a9295b3143008..f404a71c6ad5f 100644
--- a/packages/react-server/src/ReactFizzHooks.js
+++ b/packages/react-server/src/ReactFizzHooks.js
@@ -608,6 +608,11 @@ function use<T>(usable: Usable<T>): T {
             index,
           );
           if (prevThenableAtIndex !== null) {
+            if (thenable !== prevThenableAtIndex) {
+              // Avoid an unhandled rejection errors for the Promises that we'll
+              // intentionally ignore.
+              thenable.then(noop, noop);
+            }
             switch (prevThenableAtIndex.status) {
               case 'fulfilled': {
                 const fulfilledValue: T = prevThenableAtIndex.value;
diff --git a/packages/react-server/src/ReactFlightCache.js b/packages/react-server/src/ReactFlightCache.js
index 239c59143bf83..54a34990e0114 100644
--- a/packages/react-server/src/ReactFlightCache.js
+++ b/packages/react-server/src/ReactFlightCache.js
@@ -9,9 +9,22 @@
 
 import type {CacheDispatcher} from 'react-reconciler/src/ReactInternalTypes';
 
+function createSignal(): AbortSignal {
+  return new AbortController().signal;
+}
+
 export const DefaultCacheDispatcher: CacheDispatcher = {
   getCacheSignal(): AbortSignal {
-    throw new Error('Not implemented.');
+    if (!currentCache) {
+      throw new Error('Reading the cache is only supported while rendering.');
+    }
+    let entry: AbortSignal | void = (currentCache.get(createSignal): any);
+    if (entry === undefined) {
+      entry = createSignal();
+      // $FlowFixMe[incompatible-use] found when upgrading Flow
+      currentCache.set(createSignal, entry);
+    }
+    return entry;
   },
   getCacheForType<T>(resourceType: () => T): T {
     if (!currentCache) {
diff --git a/packages/react-server/src/ReactFlightHooks.js b/packages/react-server/src/ReactFlightHooks.js
index fcbcbc0ff142e..1547f29dbcfbe 100644
--- a/packages/react-server/src/ReactFlightHooks.js
+++ b/packages/react-server/src/ReactFlightHooks.js
@@ -121,6 +121,8 @@ function useId(): string {
   return ':' + currentRequest.identifierPrefix + 'S' + id.toString(32) + ':';
 }
 
+function noop(): void {}
+
 function use<T>(usable: Usable<T>): T {
   if (usable !== null && typeof usable === 'object') {
     // $FlowFixMe[method-unbinding]
@@ -147,6 +149,11 @@ function use<T>(usable: Usable<T>): T {
             index,
           );
           if (prevThenableAtIndex !== null) {
+            if (thenable !== prevThenableAtIndex) {
+              // Avoid an unhandled rejection errors for the Promises that we'll
+              // intentionally ignore.
+              thenable.then(noop, noop);
+            }
             switch (prevThenableAtIndex.status) {
               case 'fulfilled': {
                 const fulfilledValue: T = prevThenableAtIndex.value;
diff --git a/packages/react/src/React.js b/packages/react/src/React.js
index 3c3cafe88bcf6..3cb0d13a13a05 100644
--- a/packages/react/src/React.js
+++ b/packages/react/src/React.js
@@ -71,6 +71,9 @@ import ReactSharedInternals from './ReactSharedInternals';
 import {startTransition} from './ReactStartTransition';
 import {act} from './ReactAct';
 
+// Patch fetch
+import './ReactFetch';
+
 // TODO: Move this branching into the other module instead and just re-export.
 const createElement: any = __DEV__
   ? createElementWithValidation
diff --git a/packages/react/src/ReactFetch.js b/packages/react/src/ReactFetch.js
new file mode 100644
index 0000000000000..7c39cefdf3f92
--- /dev/null
+++ b/packages/react/src/ReactFetch.js
@@ -0,0 +1,133 @@
+/**
+ * Copyright (c) Facebook, Inc. and its affiliates.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ *
+ * @flow
+ */
+
+import {
+  enableCache,
+  enableFetchInstrumentation,
+} from 'shared/ReactFeatureFlags';
+
+import ReactCurrentCache from './ReactCurrentCache';
+
+function createFetchCache(): Map<string, Array<any>> {
+  return new Map();
+}
+
+const simpleCacheKey = '["GET",[],null,"follow",null,null,null,null]'; // generateCacheKey(new Request('https://blank'));
+
+function generateCacheKey(request: Request): string {
+  // We pick the fields that goes into the key used to dedupe requests.
+  // We don't include the `cache` field, because we end up using whatever
+  // caching resulted from the first request.
+  // Notably we currently don't consider non-standard (or future) options.
+  // This might not be safe. TODO: warn for non-standard extensions differing.
+  // IF YOU CHANGE THIS UPDATE THE simpleCacheKey ABOVE.
+  return JSON.stringify([
+    request.method,
+    Array.from(request.headers.entries()),
+    request.mode,
+    request.redirect,
+    request.credentials,
+    request.referrer,
+    request.referrerPolicy,
+    request.integrity,
+  ]);
+}
+
+if (enableCache && enableFetchInstrumentation) {
+  if (typeof fetch === 'function') {
+    const originalFetch = fetch;
+    try {
+      // eslint-disable-next-line no-native-reassign
+      fetch = function fetch(
+        resource: URL | RequestInfo,
+        options?: RequestOptions,
+      ) {
+        const dispatcher = ReactCurrentCache.current;
+        if (!dispatcher) {
+          // We're outside a cached scope.
+          return originalFetch(resource, options);
+        }
+        if (
+          options &&
+          options.signal &&
+          options.signal !== dispatcher.getCacheSignal()
+        ) {
+          // If we're passed a signal that is not ours, then we assume that
+          // someone else controls the lifetime of this object and opts out of
+          // caching. It's effectively the opt-out mechanism.
+          // Ideally we should be able to check this on the Request but
+          // it always gets initialized with its own signal so we don't
+          // know if it's supposed to override - unless we also override the
+          // Request constructor.
+          return originalFetch(resource, options);
+        }
+        // Normalize the Request
+        let url: string;
+        let cacheKey: string;
+        if (typeof resource === 'string' && !options) {
+          // Fast path.
+          cacheKey = simpleCacheKey;
+          url = resource;
+        } else {
+          // Normalize the request.
+          const request = new Request(resource, options);
+          if (
+            (request.method !== 'GET' && request.method !== 'HEAD') ||
+            // $FlowFixMe: keepalive is real
+            request.keepalive
+          ) {
+            // We currently don't dedupe requests that might have side-effects. Those
+            // have to be explicitly cached. We assume that the request doesn't have a
+            // body if it's GET or HEAD.
+            // keepalive gets treated the same as if you passed a custom cache signal.
+            return originalFetch(resource, options);
+          }
+          cacheKey = generateCacheKey(request);
+          url = request.url;
+        }
+        const cache = dispatcher.getCacheForType(createFetchCache);
+        const cacheEntries = cache.get(url);
+        let match;
+        if (cacheEntries === undefined) {
+          // We pass the original arguments here in case normalizing the Request
+          // doesn't include all the options in this environment.
+          match = originalFetch(resource, options);
+          cache.set(url, [cacheKey, match]);
+        } else {
+          // We use an array as the inner data structure since it's lighter and
+          // we typically only expect to see one or two entries here.
+          for (let i = 0, l = cacheEntries.length; i < l; i += 2) {
+            const key = cacheEntries[i];
+            const value = cacheEntries[i + 1];
+            if (key === cacheKey) {
+              match = value;
+              // I would've preferred a labelled break but lint says no.
+              return match.then(response => response.clone());
+            }
+          }
+          match = originalFetch(resource, options);
+          cacheEntries.push(cacheKey, match);
+        }
+        // We clone the response so that each time you call this you get a new read
+        // of the body so that it can be read multiple times.
+        return match.then(response => response.clone());
+      };
+      // We don't expect to see any extra properties on fetch but if there are any,
+      // copy them over. Useful for extended fetch environments or mocks.
+      Object.assign(fetch, originalFetch);
+    } catch (error) {
+      // Log even in production just to make sure this is seen if only prod is frozen.
+      // eslint-disable-next-line react-internal/no-production-logging
+      console.warn(
+        'React was unable to patch the fetch() function in this environment. ' +
+          'Suspensey APIs might not work correctly as a result.',
+      );
+    }
+  }
+}
diff --git a/packages/react/src/__tests__/ReactFetch-test.js b/packages/react/src/__tests__/ReactFetch-test.js
new file mode 100644
index 0000000000000..c68c697e29d6e
--- /dev/null
+++ b/packages/react/src/__tests__/ReactFetch-test.js
@@ -0,0 +1,144 @@
+/**
+ * Copyright (c) Facebook, Inc. and its affiliates.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ *
+ * @emails react-core
+ */
+
+'use strict';
+
+// Polyfills for test environment
+global.ReadableStream = require('web-streams-polyfill/ponyfill/es6').ReadableStream;
+global.TextEncoder = require('util').TextEncoder;
+global.TextDecoder = require('util').TextDecoder;
+global.Headers = require('node-fetch').Headers;
+global.Request = require('node-fetch').Request;
+global.Response = require('node-fetch').Response;
+
+let fetchCount = 0;
+async function fetchMock(resource, options) {
+  fetchCount++;
+  const request = new Request(resource, options);
+  return new Response(
+    request.method +
+      ' ' +
+      request.url +
+      ' ' +
+      JSON.stringify(Array.from(request.headers.entries())),
+  );
+}
+
+let React;
+let ReactServerDOMServer;
+let ReactServerDOMClient;
+let use;
+
+describe('ReactFetch', () => {
+  beforeEach(() => {
+    jest.resetModules();
+    fetchCount = 0;
+    global.fetch = fetchMock;
+
+    React = require('react');
+    ReactServerDOMServer = require('react-server-dom-webpack/server.browser');
+    ReactServerDOMClient = require('react-server-dom-webpack/client');
+    use = React.experimental_use;
+  });
+
+  async function render(Component) {
+    const stream = ReactServerDOMServer.renderToReadableStream(<Component />);
+    return ReactServerDOMClient.createFromReadableStream(stream);
+  }
+
+  it('can fetch duplicates outside of render', async () => {
+    let response = await fetch('world');
+    let text = await response.text();
+    expect(text).toMatchInlineSnapshot(`"GET world []"`);
+    response = await fetch('world');
+    text = await response.text();
+    expect(text).toMatchInlineSnapshot(`"GET world []"`);
+    expect(fetchCount).toBe(2);
+  });
+
+  // @gate enableFetchInstrumentation && enableCache
+  it('can dedupe fetches inside of render', async () => {
+    function Component() {
+      const response = use(fetch('world'));
+      const text = use(response.text());
+      return text;
+    }
+    expect(await render(Component)).toMatchInlineSnapshot(`"GET world []"`);
+    expect(fetchCount).toBe(1);
+  });
+
+  // @gate enableFetchInstrumentation && enableCache
+  it('can dedupe fetches using Request and not', async () => {
+    function Component() {
+      const response = use(fetch('world'));
+      const text = use(response.text());
+      const sameRequest = new Request('world', {method: 'get'});
+      const response2 = use(fetch(sameRequest));
+      const text2 = use(response2.text());
+      return text + ' ' + text2;
+    }
+    expect(await render(Component)).toMatchInlineSnapshot(
+      `"GET world [] GET world []"`,
+    );
+    expect(fetchCount).toBe(1);
+  });
+
+  // @gate enableUseHook
+  it('can opt-out of deduping fetches inside of render with custom signal', async () => {
+    const controller = new AbortController();
+    function useCustomHook() {
+      return use(
+        fetch('world', {signal: controller.signal}).then(response =>
+          response.text(),
+        ),
+      );
+    }
+    function Component() {
+      return useCustomHook() + ' ' + useCustomHook();
+    }
+    expect(await render(Component)).toMatchInlineSnapshot(
+      `"GET world [] GET world []"`,
+    );
+    expect(fetchCount).not.toBe(1);
+  });
+
+  // @gate enableUseHook
+  it('opts out of deduping for POST requests', async () => {
+    function useCustomHook() {
+      return use(
+        fetch('world', {method: 'POST'}).then(response => response.text()),
+      );
+    }
+    function Component() {
+      return useCustomHook() + ' ' + useCustomHook();
+    }
+    expect(await render(Component)).toMatchInlineSnapshot(
+      `"POST world [] POST world []"`,
+    );
+    expect(fetchCount).not.toBe(1);
+  });
+
+  // @gate enableFetchInstrumentation && enableCache
+  it('can dedupe fetches using same headers but not different', async () => {
+    function Component() {
+      const response = use(fetch('world', {headers: {a: 'A'}}));
+      const text = use(response.text());
+      const sameRequest = new Request('world', {
+        headers: new Headers({b: 'B'}),
+      });
+      const response2 = use(fetch(sameRequest));
+      const text2 = use(response2.text());
+      return text + ' ' + text2;
+    }
+    expect(await render(Component)).toMatchInlineSnapshot(
+      `"GET world [[\\"a\\",\\"A\\"]] GET world [[\\"b\\",\\"B\\"]]"`,
+    );
+    expect(fetchCount).toBe(2);
+  });
+});
diff --git a/packages/shared/ReactFeatureFlags.js b/packages/shared/ReactFeatureFlags.js
index 9caa256a1449c..32d9db7eed807 100644
--- a/packages/shared/ReactFeatureFlags.js
+++ b/packages/shared/ReactFeatureFlags.js
@@ -84,6 +84,7 @@ export const enableLegacyFBSupport = false;
 
 export const enableCache = __EXPERIMENTAL__;
 export const enableCacheElement = __EXPERIMENTAL__;
+export const enableFetchInstrumentation = __EXPERIMENTAL__;
 
 export const enableTransitionTracing = false;
 
diff --git a/packages/shared/forks/ReactFeatureFlags.native-fb.js b/packages/shared/forks/ReactFeatureFlags.native-fb.js
index c122058bc7455..6f7548f08173c 100644
--- a/packages/shared/forks/ReactFeatureFlags.native-fb.js
+++ b/packages/shared/forks/ReactFeatureFlags.native-fb.js
@@ -29,6 +29,7 @@ export const enableProfilerNestedUpdateScheduledHook = false;
 export const enableUpdaterTracking = __PROFILE__;
 export const enableCache = false;
 export const enableCacheElement = true;
+export const enableFetchInstrumentation = false;
 export const enableSchedulerDebugging = false;
 export const debugRenderPhaseSideEffectsForStrictMode = true;
 export const disableJavaScriptURLs = false;
diff --git a/packages/shared/forks/ReactFeatureFlags.native-oss.js b/packages/shared/forks/ReactFeatureFlags.native-oss.js
index 84b51658e920a..70ddeda4ea85e 100644
--- a/packages/shared/forks/ReactFeatureFlags.native-oss.js
+++ b/packages/shared/forks/ReactFeatureFlags.native-oss.js
@@ -22,6 +22,7 @@ export const enableProfilerNestedUpdateScheduledHook = false;
 export const enableUpdaterTracking = __PROFILE__;
 export const enableCache = false;
 export const enableCacheElement = false;
+export const enableFetchInstrumentation = false;
 export const disableJavaScriptURLs = false;
 export const disableCommentsAsDOMContainers = true;
 export const disableInputAttributeSyncing = false;
diff --git a/packages/shared/forks/ReactFeatureFlags.test-renderer.js b/packages/shared/forks/ReactFeatureFlags.test-renderer.js
index ae53daa68d190..5419b61697ec4 100644
--- a/packages/shared/forks/ReactFeatureFlags.test-renderer.js
+++ b/packages/shared/forks/ReactFeatureFlags.test-renderer.js
@@ -22,6 +22,7 @@ export const enableProfilerNestedUpdateScheduledHook = false;
 export const enableUpdaterTracking = false;
 export const enableCache = __EXPERIMENTAL__;
 export const enableCacheElement = __EXPERIMENTAL__;
+export const enableFetchInstrumentation = __EXPERIMENTAL__;
 export const disableJavaScriptURLs = false;
 export const disableCommentsAsDOMContainers = true;
 export const disableInputAttributeSyncing = false;
diff --git a/packages/shared/forks/ReactFeatureFlags.test-renderer.native.js b/packages/shared/forks/ReactFeatureFlags.test-renderer.native.js
index 656bf8961d61e..c95aae7a55fa4 100644
--- a/packages/shared/forks/ReactFeatureFlags.test-renderer.native.js
+++ b/packages/shared/forks/ReactFeatureFlags.test-renderer.native.js
@@ -22,6 +22,7 @@ export const enableProfilerNestedUpdateScheduledHook = false;
 export const enableUpdaterTracking = false;
 export const enableCache = true;
 export const enableCacheElement = true;
+export const enableFetchInstrumentation = false;
 export const disableJavaScriptURLs = false;
 export const disableCommentsAsDOMContainers = true;
 export const disableInputAttributeSyncing = false;
diff --git a/packages/shared/forks/ReactFeatureFlags.test-renderer.www.js b/packages/shared/forks/ReactFeatureFlags.test-renderer.www.js
index 0b35db3a8ea55..6fdd83b52a8fe 100644
--- a/packages/shared/forks/ReactFeatureFlags.test-renderer.www.js
+++ b/packages/shared/forks/ReactFeatureFlags.test-renderer.www.js
@@ -22,6 +22,7 @@ export const enableProfilerNestedUpdateScheduledHook = false;
 export const enableUpdaterTracking = false;
 export const enableCache = true;
 export const enableCacheElement = true;
+export const enableFetchInstrumentation = false;
 export const enableSchedulerDebugging = false;
 export const disableJavaScriptURLs = false;
 export const disableCommentsAsDOMContainers = true;
diff --git a/packages/shared/forks/ReactFeatureFlags.testing.js b/packages/shared/forks/ReactFeatureFlags.testing.js
index e471b432f8fe3..c3b2d18890022 100644
--- a/packages/shared/forks/ReactFeatureFlags.testing.js
+++ b/packages/shared/forks/ReactFeatureFlags.testing.js
@@ -22,6 +22,7 @@ export const enableProfilerNestedUpdateScheduledHook = false;
 export const enableUpdaterTracking = false;
 export const enableCache = __EXPERIMENTAL__;
 export const enableCacheElement = __EXPERIMENTAL__;
+export const enableFetchInstrumentation = __EXPERIMENTAL__;
 export const disableJavaScriptURLs = false;
 export const disableCommentsAsDOMContainers = true;
 export const disableInputAttributeSyncing = false;
diff --git a/packages/shared/forks/ReactFeatureFlags.testing.www.js b/packages/shared/forks/ReactFeatureFlags.testing.www.js
index f41249dad84cc..042b1cfa41a43 100644
--- a/packages/shared/forks/ReactFeatureFlags.testing.www.js
+++ b/packages/shared/forks/ReactFeatureFlags.testing.www.js
@@ -22,6 +22,7 @@ export const enableProfilerNestedUpdateScheduledHook = false;
 export const enableUpdaterTracking = false;
 export const enableCache = true;
 export const enableCacheElement = true;
+export const enableFetchInstrumentation = false;
 export const disableJavaScriptURLs = true;
 export const disableCommentsAsDOMContainers = true;
 export const disableInputAttributeSyncing = false;
diff --git a/packages/shared/forks/ReactFeatureFlags.www.js b/packages/shared/forks/ReactFeatureFlags.www.js
index 92739ff777b3c..5819d2a1f8e57 100644
--- a/packages/shared/forks/ReactFeatureFlags.www.js
+++ b/packages/shared/forks/ReactFeatureFlags.www.js
@@ -72,6 +72,7 @@ export const enableGetInspectorDataForInstanceInProduction = false;
 
 export const enableCache = true;
 export const enableCacheElement = true;
+export const enableFetchInstrumentation = false;
 
 export const disableJavaScriptURLs = true;
 
diff --git a/yarn.lock b/yarn.lock
index 8c2ade1055d95..01849164caeaf 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -2,6 +2,11 @@
 # yarn lockfile v1
 
 
+"@actuallyworks/node-fetch@^2.6.0":
+  version "2.6.0"
+  resolved "https://registry.yarnpkg.com/@actuallyworks/node-fetch/-/node-fetch-2.6.0.tgz#d1adc48813ab2866d86481950b99287c8d22d677"
+  integrity sha512-4G5iCA6JJk5TYy9GqSyyjGIOnf1w/K+XvCdVDm/Q6ryQGPhAwIGyZpIkPMLFStdjoswlgJTiY64j3yMw4S6l8g==
+
 "@babel/cli@^7.10.5":
   version "7.10.5"
   resolved "https://registry.yarnpkg.com/@babel/cli/-/cli-7.10.5.tgz#57df2987c8cf89d0fc7d4b157ec59d7619f1b77a"