diff --git a/package-lock.json b/package-lock.json
index 20860b3e90..76c7c993bd 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -19499,6 +19499,7 @@
         "base64url": "^3.0.1",
         "bl": "^1.1.2",
         "debug": "^4.3.3",
+        "ethereum-cryptography": "^1.0.3",
         "hi-base32": "^0.5.0",
         "inherits": "^2.0.1",
         "ip": "^1.1.3",
@@ -19509,7 +19510,6 @@
         "multiaddr": "^10.0.1",
         "rlp": "^3.0.0",
         "scanf": "^1.1.2",
-        "secp256k1": "^4.0.2",
         "snappyjs": "^0.6.1"
       },
       "devDependencies": {
@@ -19521,7 +19521,6 @@
         "@types/keccak": "^3.0.1",
         "@types/ms": "^0.7.30",
         "@types/node": "^16.11.7",
-        "@types/secp256k1": "^4.0.1",
         "@types/tape": "^4.13.2",
         "chalk": "^2.4.2",
         "eslint": "^6.8.0",
@@ -20428,13 +20427,13 @@
         "@types/lru-cache": "^5.1.0",
         "@types/ms": "^0.7.30",
         "@types/node": "^16.11.7",
-        "@types/secp256k1": "^4.0.1",
         "@types/tape": "^4.13.2",
         "base64url": "^3.0.1",
         "bl": "^1.1.2",
         "chalk": "^2.4.2",
         "debug": "^4.3.3",
         "eslint": "^6.8.0",
+        "ethereum-cryptography": "^1.0.3",
         "hi-base32": "^0.5.0",
         "inherits": "^2.0.1",
         "ip": "^1.1.3",
@@ -20447,7 +20446,6 @@
         "prettier": "^2.0.5",
         "rlp": "^3.0.0",
         "scanf": "^1.1.2",
-        "secp256k1": "^4.0.2",
         "snappyjs": "^0.6.1",
         "tape": "^5.3.1",
         "testdouble": "^3.8.2",
diff --git a/packages/devp2p/package.json b/packages/devp2p/package.json
index 0f67c2db79..3aae73ed2d 100644
--- a/packages/devp2p/package.json
+++ b/packages/devp2p/package.json
@@ -42,24 +42,22 @@
   },
   "dependencies": {
     "@ethereumjs/common": "^2.6.4",
+    "@scure/base": "1.1.1",
     "@types/bl": "^2.1.0",
     "@types/k-bucket": "^5.0.0",
     "@types/lru-cache": "^5.1.0",
-    "base64url": "^3.0.1",
     "bl": "^1.1.2",
     "debug": "^4.3.3",
     "@ethereumjs/util": "^8.0.0",
-    "hi-base32": "^0.5.0",
+    "ethereum-cryptography": "^1.1.0",
     "inherits": "^2.0.1",
     "ip": "^1.1.3",
     "k-bucket": "^5.0.0",
-    "keccak": "^3.0.1",
     "lru-cache": "^5.1.1",
     "ms": "^0.7.1",
     "multiaddr": "^10.0.1",
     "rlp": "^3.0.0",
     "scanf": "^1.1.2",
-    "secp256k1": "^4.0.2",
     "snappyjs": "^0.6.1"
   },
   "devDependencies": {
@@ -68,10 +66,8 @@
     "@types/chalk": "^2.2.0",
     "@types/debug": "^4.1.4",
     "@types/ip": "^1.1.0",
-    "@types/keccak": "^3.0.1",
     "@types/ms": "^0.7.30",
     "@types/node": "^16.11.7",
-    "@types/secp256k1": "^4.0.1",
     "@types/tape": "^4.13.2",
     "chalk": "^2.4.2",
     "eslint": "^6.8.0",
diff --git a/packages/devp2p/src/dns/enr.ts b/packages/devp2p/src/dns/enr.ts
index ca6d80e0bd..9ce64c1525 100644
--- a/packages/devp2p/src/dns/enr.ts
+++ b/packages/devp2p/src/dns/enr.ts
@@ -1,12 +1,11 @@
-import * as base32 from 'hi-base32'
+import { base32, base64url } from '@scure/base'
 import { sscanf } from 'scanf'
-import { ecdsaVerify } from 'secp256k1'
 import { Multiaddr } from 'multiaddr'
-import base64url from 'base64url'
 import { arrToBufArr, bufArrToArr } from '@ethereumjs/util'
 import RLP from 'rlp'
 import { PeerInfo } from '../dpt'
 import { toNewUint8Array, keccak256 } from '../util'
+import { ecdsaVerify } from 'ethereum-cryptography/secp256k1-compat'
 
 const Convert = require('multiaddr/src/convert')
 
@@ -52,7 +51,7 @@ export class ENR {
       throw new Error(`String encoded ENR must start with '${this.RECORD_PREFIX}'`)
 
     // ENRs are RLP encoded and written to DNS TXT entries as base64 url-safe strings
-    const base64BufferEnr = base64url.toBuffer(enr.slice(this.RECORD_PREFIX.length))
+    const base64BufferEnr = Buffer.from(base64url.decode(enr.slice(this.RECORD_PREFIX.length)))
     const decoded = arrToBufArr(RLP.decode(Uint8Array.from(base64BufferEnr))) as Buffer[]
     const [signature, seq, ...kvs] = decoded
 
@@ -109,14 +108,17 @@ export class ENR {
     if (!rootVals.seq) throw new Error("Could not parse 'seq' value from ENR root entry")
     if (!rootVals.signature) throw new Error("Could not parse 'sig' value from ENR root entry")
 
-    const decodedPublicKey = base32.decode.asBytes(publicKey)
+    const decodedPublicKey = [...base32.decode(publicKey + '===').values()]
 
     // The signature is a 65-byte secp256k1 over the keccak256 hash
     // of the record content, excluding the `sig=` part, encoded as URL-safe base64 string
     // (Trailing recovery bit must be trimmed to pass `ecdsaVerify` method)
     const signedComponent = root.split(' sig')[0]
     const signedComponentBuffer = Buffer.from(signedComponent)
-    const signatureBuffer = base64url.toBuffer(rootVals.signature).slice(0, 64)
+    const signatureBuffer = Buffer.from(
+      [...base64url.decode(rootVals.signature + '=').values()].slice(0, 64)
+    )
+
     const keyBuffer = Buffer.from(decodedPublicKey)
 
     const isVerified = ecdsaVerify(signatureBuffer, keccak256(signedComponentBuffer), keyBuffer)
diff --git a/packages/devp2p/src/dpt/dpt.ts b/packages/devp2p/src/dpt/dpt.ts
index 274204d9dd..a87eeb4af1 100644
--- a/packages/devp2p/src/dpt/dpt.ts
+++ b/packages/devp2p/src/dpt/dpt.ts
@@ -1,6 +1,6 @@
 import ms from 'ms'
 import { EventEmitter } from 'events'
-import { publicKeyCreate } from 'secp256k1'
+import { getPublicKey } from 'ethereum-cryptography/secp256k1'
 import { randomBytes } from 'crypto'
 // import { debug as createDebugLogger } from 'debug'
 import { devp2pDebug } from '../util'
@@ -106,7 +106,7 @@ export class DPT extends EventEmitter {
     super()
 
     this.privateKey = Buffer.from(privateKey)
-    this._id = pk2id(Buffer.from(publicKeyCreate(this.privateKey, false)))
+    this._id = pk2id(Buffer.from(getPublicKey(this.privateKey, false)))
     this._shouldFindNeighbours = options.shouldFindNeighbours === false ? false : true
     this._shouldGetDnsPeers = options.shouldGetDnsPeers ?? false
     // By default, tries to connect to 12 new peers every 3s
diff --git a/packages/devp2p/src/dpt/message.ts b/packages/devp2p/src/dpt/message.ts
index fefd42bdec..8c3d376dcf 100644
--- a/packages/devp2p/src/dpt/message.ts
+++ b/packages/devp2p/src/dpt/message.ts
@@ -1,8 +1,8 @@
 import { debug as createDebugLogger } from 'debug'
 import ip from 'ip'
-import secp256k1 from 'secp256k1'
 import { bufArrToArr } from '@ethereumjs/util'
 import RLP from 'rlp'
+import { ecdsaRecover, ecdsaSign } from 'ethereum-cryptography/secp256k1-compat'
 import { keccak256, int2buffer, buffer2int, assertEq, unstrictDecode } from '../util'
 import { PeerInfo } from './dpt'
 
@@ -176,7 +176,7 @@ export function encode<T>(typename: string, data: T, privateKey: Buffer) {
   ])
 
   const sighash = keccak256(typedata)
-  const sig = secp256k1.ecdsaSign(sighash, privateKey)
+  const sig = ecdsaSign(sighash, privateKey)
   const hashdata = Buffer.concat([Buffer.from(sig.signature), Buffer.from([sig.recid]), typedata])
   const hash = keccak256(hashdata)
   return Buffer.concat([hash, hashdata])
@@ -195,7 +195,7 @@ export function decode(buffer: Buffer) {
   const sighash = keccak256(typedata)
   const signature = buffer.slice(32, 96)
   const recoverId = buffer[96]
-  const publicKey = Buffer.from(secp256k1.ecdsaRecover(signature, recoverId, sighash, false))
+  const publicKey = Buffer.from(ecdsaRecover(signature, recoverId, sighash, false))
 
   return { typename, data, publicKey }
 }
diff --git a/packages/devp2p/src/rlpx/ecies.ts b/packages/devp2p/src/rlpx/ecies.ts
index 06488088ef..e1053b4a82 100644
--- a/packages/devp2p/src/rlpx/ecies.ts
+++ b/packages/devp2p/src/rlpx/ecies.ts
@@ -1,8 +1,8 @@
 import crypto, { Decipher } from 'crypto'
 import { debug as createDebugLogger } from 'debug'
-import { publicKeyCreate, ecdh, ecdsaRecover, ecdsaSign } from 'secp256k1'
 import { bufArrToArr } from '@ethereumjs/util'
 import RLP from 'rlp'
+import { getPublicKey } from 'ethereum-cryptography/secp256k1'
 import { unstrictDecode } from '../util'
 import { MAC } from './mac'
 
@@ -17,6 +17,7 @@ import {
   buffer2int,
   zfill,
 } from '../util'
+import { ecdsaSign, ecdsaRecover, ecdh } from 'ethereum-cryptography/secp256k1-compat'
 
 const debug = createDebugLogger('devp2p:rlpx:peer')
 
@@ -26,10 +27,9 @@ function ecdhX(publicKey: Buffer, privateKey: Buffer) {
     const pubKey = new Uint8Array(33)
     pubKey[0] = (y[31] & 1) === 0 ? 0x02 : 0x03
     pubKey.set(x, 1)
-    return pubKey
+    return pubKey.slice(1)
   }
-  // @ts-ignore
-  return Buffer.from(ecdh(publicKey, privateKey, { hashfn }, Buffer.alloc(33)).slice(1))
+  return Buffer.from(ecdh(publicKey, privateKey, { hashfn: hashfn }, Buffer.alloc(32)))
 }
 
 // a straigth rip from python interop w/go ecies implementation
@@ -80,7 +80,7 @@ export class ECIES {
 
     this._nonce = crypto.randomBytes(32)
     this._ephemeralPrivateKey = genPrivateKey()
-    this._ephemeralPublicKey = Buffer.from(publicKeyCreate(this._ephemeralPrivateKey, false))
+    this._ephemeralPublicKey = Buffer.from(getPublicKey(this._ephemeralPrivateKey, false))
   }
 
   _encryptMessage(data: Buffer, sharedMacData: Buffer | null = null): Buffer | undefined {
@@ -106,7 +106,7 @@ export class ECIES {
       .update(Buffer.concat([dataIV, sharedMacData]))
       .digest()
 
-    const publicKey = publicKeyCreate(privateKey, false)
+    const publicKey = getPublicKey(privateKey, false)
     return Buffer.concat([publicKey, dataIV, tag])
   }
 
diff --git a/packages/devp2p/src/rlpx/mac.ts b/packages/devp2p/src/rlpx/mac.ts
index b9a6800a5d..e14c3b3de8 100644
--- a/packages/devp2p/src/rlpx/mac.ts
+++ b/packages/devp2p/src/rlpx/mac.ts
@@ -1,12 +1,14 @@
 import { createCipheriv } from 'crypto'
-import createKeccakHash from 'keccak'
+import { keccak256 } from 'ethereum-cryptography/keccak'
 import { xor } from '../util'
 
+export type Hash = ReturnType<typeof keccak256.create>
+
 export class MAC {
-  _hash: any
+  _hash: Hash
   _secret: Buffer
   constructor(secret: Buffer) {
-    this._hash = createKeccakHash('keccak256')
+    this._hash = keccak256.create()
     this._secret = secret
   }
 
@@ -29,6 +31,6 @@ export class MAC {
   }
 
   digest() {
-    return this._hash._clone().digest().slice(0, 16)
+    return Buffer.from(this._hash.clone().digest().slice(0, 16))
   }
 }
diff --git a/packages/devp2p/src/rlpx/rlpx.ts b/packages/devp2p/src/rlpx/rlpx.ts
index fe2fb73790..a16969bacb 100644
--- a/packages/devp2p/src/rlpx/rlpx.ts
+++ b/packages/devp2p/src/rlpx/rlpx.ts
@@ -1,7 +1,7 @@
 import * as net from 'net'
 import * as os from 'os'
 import ms from 'ms'
-import { publicKeyCreate } from 'secp256k1'
+import { getPublicKey } from 'ethereum-cryptography/secp256k1'
 import { EventEmitter } from 'events'
 import { debug as createDebugLogger, Debugger } from 'debug'
 import { devp2pDebug } from '../util'
@@ -54,7 +54,7 @@ export class RLPx extends EventEmitter {
     super()
 
     this._privateKey = Buffer.from(privateKey)
-    this._id = pk2id(Buffer.from(publicKeyCreate(this._privateKey, false)))
+    this._id = pk2id(Buffer.from(getPublicKey(this._privateKey, false)))
 
     // options
     this._timeout = options.timeout ?? ms('10s')
diff --git a/packages/devp2p/src/util.ts b/packages/devp2p/src/util.ts
index 1c27da4e79..7bff5468f5 100644
--- a/packages/devp2p/src/util.ts
+++ b/packages/devp2p/src/util.ts
@@ -1,8 +1,8 @@
-import { randomBytes } from 'crypto'
-import { privateKeyVerify, publicKeyConvert } from 'secp256k1'
-import createKeccakHash from 'keccak'
 import { arrToBufArr } from '@ethereumjs/util'
 import RLP from 'rlp'
+import { utils } from 'ethereum-cryptography/secp256k1'
+import { publicKeyConvert } from 'ethereum-cryptography/secp256k1-compat'
+import { keccak256 as _keccak256 } from 'ethereum-cryptography/keccak'
 import { ETH } from './protocol/eth'
 import { LES } from './protocol/les'
 import { debug as createDebugLogger } from 'debug'
@@ -11,12 +11,12 @@ export const devp2pDebug = createDebugLogger('devp2p')
 
 export function keccak256(...buffers: Buffer[]) {
   const buffer = Buffer.concat(buffers)
-  return createKeccakHash('keccak256').update(buffer).digest()
+  return Buffer.from(_keccak256(buffer))
 }
 
 export function genPrivateKey(): Buffer {
-  const privateKey = randomBytes(32)
-  return privateKeyVerify(privateKey) ? privateKey : genPrivateKey()
+  const privateKey = utils.randomPrivateKey()
+  return utils.isValidPrivateKey(privateKey) ? Buffer.from(privateKey) : genPrivateKey()
 }
 
 export function pk2id(pk: Buffer): Buffer {
diff --git a/packages/devp2p/test/dpt-message.ts b/packages/devp2p/test/dpt-message.ts
index df5b245271..40534b7265 100644
--- a/packages/devp2p/test/dpt-message.ts
+++ b/packages/devp2p/test/dpt-message.ts
@@ -1,12 +1,12 @@
+import { publicKeyCreate } from 'ethereum-cryptography/secp256k1-compat'
 import test from 'tape'
-import * as secp256k1 from 'secp256k1'
 import * as message from '../src/dpt/message'
 
 const privateKey = Buffer.from(
   'b71c71a67e1177ad4e901695e1b4b9ee17ae16c6668d313eac2f96dbcda3f291',
   'hex'
 )
-const publicKey = Buffer.from(secp256k1.publicKeyCreate(privateKey, false))
+const publicKey = Buffer.from(publicKeyCreate(privateKey, false))
 
 test('ping packet with version 4, additional list elements', (t) => {
   const buffer = Buffer.from(
diff --git a/packages/devp2p/test/rlpx-ecies.ts b/packages/devp2p/test/rlpx-ecies.ts
index f99bb012da..854654e862 100644
--- a/packages/devp2p/test/rlpx-ecies.ts
+++ b/packages/devp2p/test/rlpx-ecies.ts
@@ -1,10 +1,10 @@
 import { randomBytes } from 'crypto'
-import * as secp256k1 from 'secp256k1'
 import test, { Test } from 'tape'
 import * as util from '../src/util'
 import { ECIES } from '../src/rlpx/ecies'
 
 import testdata from './testdata.json'
+import { publicKeyCreate } from 'ethereum-cryptography/secp256k1-compat'
 
 declare module 'tape' {
   export interface Test {
@@ -16,8 +16,8 @@ function randomBefore(fn: Function) {
   return (t: Test) => {
     const privateKey1 = util.genPrivateKey()
     const privateKey2 = util.genPrivateKey()
-    const publicKey1 = Buffer.from(secp256k1.publicKeyCreate(privateKey1, false))
-    const publicKey2 = Buffer.from(secp256k1.publicKeyCreate(privateKey2, false))
+    const publicKey1 = Buffer.from(publicKeyCreate(privateKey1, false))
+    const publicKey2 = Buffer.from(publicKeyCreate(privateKey2, false))
     t.context = {
       a: new ECIES(privateKey1, util.pk2id(publicKey1), util.pk2id(publicKey2)),
       b: new ECIES(privateKey2, util.pk2id(publicKey2), util.pk2id(publicKey1)),