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cnvkit.py coverage does not honor -q option #913

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ishida-md opened this issue Sep 13, 2024 · 0 comments
Open

cnvkit.py coverage does not honor -q option #913

ishida-md opened this issue Sep 13, 2024 · 0 comments

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@ishida-md
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Hi, I am running the latest cnvkit image on the docker hub.
I get spurious calls where many reads with mapq = 0. I tried cnvkit.py coverage with the -q option, but it does not do anything. Is this a bug?

Here is the snippet:
singularity exec -e --env OMP_NUM_THREADS=1 --bind /home cnvkit_0.9.11.sif cnvkit.py coverage -o mapq0.cnn test.bam xgen.t750.bed

singularity exec -e --env OMP_NUM_THREADS=1 --bind /home cnvkit_0.9.11.sif cnvkit.py coverage -o mapq60.cnn -q 60 test.markdup.bam xgen.t750.bed

mapq0.cnn and mapq60.cnn are identical although I see a lot of mapq = 0 reads on IGV.

@ishida-md ishida-md changed the title coverage does not honor -q option cnvkit.py coverage does not honor -q option Sep 13, 2024
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