diff --git a/cmd/capi/CMakeLists.txt b/cmd/capi/CMakeLists.txt
index d066f6e068..b6453d1046 100644
--- a/cmd/capi/CMakeLists.txt
+++ b/cmd/capi/CMakeLists.txt
@@ -31,6 +31,9 @@ set(PRIVATE_LIBS
 
 target_link_libraries(execute PRIVATE ${PRIVATE_LIBS})
 
-# Target 'capi_main' is used to check that Silkworm C API header passes pure C compilation
-add_executable(capi_main main.c)
-target_link_libraries(capi_main PRIVATE silkworm_capi)
+# Target 'capi_main' is used to check that Silkworm C API header passes pure C compilation (avoid this target in
+# sanitizer build due to linking errors w/ libFuzzingEngine dependencies)
+if(NOT SILKWORM_SANITIZE)
+  add_executable(capi_main main.c)
+  target_link_libraries(capi_main PRIVATE silkworm_capi)
+endif()