diff --git a/src/meta_basic_block.cc b/src/meta_basic_block.cc
index f2e8092..319f6b2 100644
--- a/src/meta_basic_block.cc
+++ b/src/meta_basic_block.cc
@@ -12,6 +12,9 @@ static bool IsJumpInstruction(const triton::arch::Instruction& instr);
 static void MergeLinkedBasicBlocks(const BasicBlockEdge& edge,
                                    MetaBasicBlock& root_bb,
                                    MetaBasicBlock& target_bb);
+static triton::arch::BasicBlock RemoveNopLikeInstructions(
+    const triton::Context& triton_context,
+    const triton::arch::BasicBlock& triton_bb, bool padding = false);
 
 // Transform a given "Binary Ninja" basic block into one or several
 // `MetaBasicBlock`s that can be simplified with Triton
@@ -222,6 +225,94 @@ static bool IsJumpInstruction(const triton::arch::Instruction& instr) {
   }
 }
 
+// Function inspired from Triton's DSE utility.
+// This function looks for instruction that behave like NOP instructions and
+// removes them from the given basic block and returns a new basic block as a
+// result.
+static triton::arch::BasicBlock RemoveNopLikeInstructions(
+    const triton::Context& triton, const triton::arch::BasicBlock& triton_bb,
+    bool padding) {
+  triton::arch::BasicBlock in = triton_bb;
+  triton::arch::BasicBlock out;
+
+  const auto nop_instr = [&]() {
+    triton::Context tmp_ctx(triton.getArchitecture());
+    return tmp_ctx.getNopInstruction();
+  }();
+
+  triton::arch::Architecture arch;
+  arch.setArchitecture(triton.getArchitecture());
+  const auto& pc_reg = arch.getProgramCounter();
+
+  auto last_addr = in.getFirstAddress();
+  for (auto& instr : in.getInstructions()) {
+    triton::Context tmp_ctx(triton.getArchitecture());
+    // Symbolize all registers
+    for (auto& [reg_t, reg] : tmp_ctx.getAllRegisters()) {
+      tmp_ctx.symbolizeRegister(reg);
+    }
+    // Concretize RIP
+    const auto instruction_addr = instr.getAddress();
+    tmp_ctx.setConcreteRegisterValue(pc_reg, instruction_addr);
+
+    // Execute instruction symbolically
+    tmp_ctx.processing(instr);
+    const auto post_instruction_addr = tmp_ctx.getConcreteRegisterValue(pc_reg);
+
+    // Iterate over all symbolic expressions generated by the instruction and
+    // keep only those who modified the CPU or memory state meaningfully
+    std::vector<triton::engines::symbolic::SharedSymbolicExpression>
+        effectual_symbolic_expressions;
+    for (const auto& expr : instr.symbolicExpressions) {
+      // Check for PC being assigned the value of the instruction located right
+      // after the one we executed
+      if (expr->getOriginRegister().getId() == pc_reg.getId()) {
+        if (post_instruction_addr > instruction_addr &&
+            post_instruction_addr - instruction_addr == instr.getSize()) {
+          // Instruction doesn't "jump around", ignore PC-related assignment
+          continue;
+        }
+      }
+
+      // Check for same-register assignments
+      if (expr->isRegister()) {
+        const auto& lhs_origin_reg = expr->getOriginRegister();
+        if (expr->getAst()->getType() == triton::ast::REFERENCE_NODE) {
+          auto* reference_node = reinterpret_cast<triton::ast::ReferenceNode*>(
+              expr->getAst().get());
+          const auto& rhs_origin_reg =
+              reference_node->getSymbolicExpression()->getOriginRegister();
+          if (lhs_origin_reg.getId() == rhs_origin_reg.getId()) {
+            // Both sides of the assignment contain the same symbolic register,
+            // ignore
+            continue;
+          }
+        }
+      }
+
+      effectual_symbolic_expressions.push_back(expr);
+    }
+
+    // Check instruction's side effects
+    if (effectual_symbolic_expressions.empty()) {
+      // Instruction has no side effects, get rid of it
+      if (padding) {
+        // Replace with a nop padding of the appropriate size
+        while (instr.getAddress() > last_addr) {
+          out.add(nop_instr);
+          last_addr += nop_instr.getSize();
+        }
+      }
+    } else {
+      // Instruction has side effects, keep it in the basic block
+      out.add(instr);
+    }
+    last_addr = instr.getNextAddress();
+  }
+
+  return out;
+}
+
 // Simplify the given `MetaBasicBlock`s with Triton's dead store elimination
 // pass
 std::vector<MetaBasicBlock> SimplifyMetaBasicBlocks(
@@ -242,6 +333,8 @@ std::vector<MetaBasicBlock> SimplifyMetaBasicBlocks(
           // Simplify basic blocks and disassemble the result
           try {
             auto simplified_triton_bb = triton.simplify(meta_bb.triton_bb());
+            simplified_triton_bb =
+                RemoveNopLikeInstructions(triton, simplified_triton_bb);
             triton.disassembly(simplified_triton_bb, meta_bb.GetStart());
             meta_bb.set_triton_bb(simplified_triton_bb);
             return std::move(meta_bb);