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re_evolve.cpp
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re_evolve.cpp
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#include <iostream>
#include <random>
#include <vector>
#include <utility>
#include <iomanip>
#include <cmath>
#include <array>
#include <ostream>
#include <fstream>
using namespace std;
namespace {
ofstream take_log_type("data_re_type_number.log");
ofstream take_log_network("data_re_network.log");
ofstream take_log_outside("data_re_outside.log");
ofstream take_log_devdev("data_re_devdev.log");
ofstream take_log_coef("data_re_coef.log");
ofstream take_log_inside("data_re_inside.log");
ofstream take_log_vsum("data_re_vsum.log");
}
#define rep(i, n) for (int i = 0; i < n; i++)
double rd(void)
{
double get;
get = (double)(rand() % 1000) * 0.001 + 0.001;
return get;
}
double rand_normal(double mu, double sigma)
{
double z = sqrt(- 2.0 * log(rd())) * sin(2.0 * M_PI * rd());
return mu + sigma * z;
}
double get_rand_normal(double size)
{
double get;
get = rand_normal(size, size * 0.25);
return get;
}
const int cell_max = 100;
int cell_type = 1;
const int time_end = 1000000;
const double time_bunkai = 0.1;
const int run_time = 1;
const int init_box_size = 1200;
const int max_cell_size = 10;
double box_con;
const int N = 10;
int cell_number;
double box_size;
double reversible[N][N];
double coef_decrease[N];
double nut_coef;
double nut_reversible;
double aver_nut;
double v_sum;
typedef struct
{
int type;
double inside_nut;
int nut_cat;
double mol[N];
double nut_zero_coef;
double coef[N][N];
// double go[N];
int catalyst[N][N];
double size;
double init_last;
double init_last_con;
double init_size;
} Cell;
Cell cell[cell_max];
Cell def;
double outside_nut;
double outside[N];
double go[N];
int _count = 0;
int count_ = 0;
double decide_box_nut(int time)
{
return aver_nut;
}
double get_size(Cell p)
{
double sum = p.inside_nut;
rep(i, N) {
sum += p.mol[i];
}
return sum;
}
double get_box_size(void)
{
double sum = 0;
rep(i, cell_number) {
sum += cell[i].size;
}
return init_box_size - sum;
}
array<array<double, N>, 10000> begin_coef;
void sum_ten_init(void)
{
//coefの合計が一定でその中でrandomをつくる関数
double sum = 0;
array<double, N> keep;
for (int i = 0; i < cell_type; i++) {
rep(j, N) {
keep.at(j) = rand() % rand();
keep.at(j) *= rand();
sum += keep.at(j);
}
rep(j, N) {
begin_coef.at(i).at(j) = 10 * keep.at(j) / sum;
}
sum = 0;
}
}
void desig_init(void)
{
rep(i, cell_type) {
rep(j, N) {
cin >> begin_coef.at(i).at(j);
}
}
}
void all_init(void)
{
rep(i, N) {
if (i % 3 != 2) begin_coef.at(0).at(i) = 0.4;
else begin_coef.at(0).at(i) = 2.4;
}
}
void network(void)
{
rep(k, cell_type) {
rep(i, N) {
rep(j, N) {
if (i == j) continue;
cell[i].coef[i][j] = (double)(rand() % 100) * 0.01;
}
}
}
}
void init(void)
{
//defをいれておいて、typeカウントを防ぐ
def.type = - 1;
rep(i, N) cell[i] = def;
//coefの定め方
// sum_ten_init();
all_init();
cell_number = cell_type;
//cellごとの詳細設定
rep(i, cell_type) {
cell[i].nut_zero_coef = begin_coef.at(i).at(0);
// cell[i].nut_zero_coef = 0;
cell[i].type = i;
rep(j, N) {
// cell[i].mol[j] = get_rand_normal(0.2);
cell[i].mol[j] = 0.2;
// cell[i].inside_nut = get_rand_normal(0.2);
cell[i].inside_nut = 0.2;
// cell[i].mol[j] = 0;
// cell[i].inside_nut = 0;
cell[i].nut_cat = N - 2;
if (j != N - 1) {
cell[i].coef[j][j + 1] = begin_coef.at(i).at(j + 1);
cell[i].catalyst[j][j + 1] = (j - 2 + N) % N;
reversible[j][j + 1] = 0;
}
}
cell[i].size = get_size(cell[i]);
cell[i].init_size = cell[i].size;
cell[i].init_last = cell[i].mol[N - 1];
cell[i].init_last_con = cell[i].mol[N - 1] / cell[i].size;
}
cell_number = cell_max - 1;
rep(i, cell_number) {
cell[i] = cell[0];
}
box_size = get_box_size();
// network();
nut_coef = 0.1;
nut_reversible = 0;
aver_nut = 0.01;
// aver_nut = 1.0;
//outside系はloopの外
outside_nut = aver_nut * box_size;
rep(i, N) {
outside[i] = 0;
go[i] = (i % 3 / 2) * 0.2;
coef_decrease[i] = 0;
}
}
//outside分だけはglobalでここで宣言しておく
double prev_outside_nut_con;
double new_outside_nut_con;
double prev_outside_con[N];
double new_outside_con[N];
int a[1000];
int devdev = 0;
Cell internal(Cell p)
{
double new_con[N];
double prev_con[N];
//数から濃度へ変換
rep(i, N) {
prev_con[i] = p.mol[i] / p.size;
new_con[i] = prev_con[i];
}
double prev_nut_con = p.inside_nut / p.size;
double new_nut_con = prev_nut_con;
//細胞内外の栄養の流出入
// cout << pow(p.size, - 1.0 / 3.0) << endl;
new_nut_con += time_bunkai * nut_coef * /*( pow(p.size, - 1.0 / 3.0) */ (prev_outside_nut_con - prev_nut_con);
new_outside_nut_con -= time_bunkai * nut_coef * /* pow(p.size, - 1.0 / 3.0) */ (prev_outside_nut_con - prev_nut_con) * p.size / box_size;
//ただのリアクション
new_con[0] += time_bunkai * p.nut_zero_coef * prev_nut_con * prev_con[p.nut_cat];
new_nut_con -= time_bunkai * p.nut_zero_coef * prev_nut_con * prev_con[p.nut_cat];
rep(i, N - 1) {
new_con[i + 1] += time_bunkai * p.coef[i][i + 1] * prev_con[i] * prev_con[p.catalyst[i][i + 1]];
new_con[i] -= time_bunkai * p.coef[i][i + 1] * prev_con[i] * prev_con[p.catalyst[i][i + 1]];
}
//可逆反応
new_nut_con += time_bunkai * nut_reversible * prev_con[0];
new_con[0] -= time_bunkai * nut_reversible * prev_con[0];
rep(i, N - 1) {
new_con[i] += time_bunkai * reversible[i][i + 1] * prev_con[i + 1];
new_con[i + 1] -= time_bunkai * reversible[i][i + 1] * prev_con[i + 1];
}
//細胞内外の溶質の流出入
rep(i, N) {
new_con[i] += time_bunkai * go[i] * /*pow(p.size, - 1.0 / 3.0) */ (prev_outside_con[i] - prev_con[i]);
new_outside_con[i] -= time_bunkai * go[i] /* pow(p.size, - 1.0 / 3.0) */ * (prev_outside_con[i] - prev_con[i]) * p.size / box_size;
}
//濃度から数に戻して挿入
rep(i, N) {
p.mol[i] = new_con[i] * p.size;
}
p.inside_nut = new_nut_con * p.size;
//サイズを増やす
double sum = new_nut_con;
rep(i, N) {
sum += new_con[i];
}
p.size = sum * p.size;
return p;
}
void evolve(void)
{
double sum = 0;
array<double, N> keep;
rep(j, N) {
keep.at(j) = rand();
sum += keep.at(j);
}
rep(j, N) {
begin_coef.at(cell_type).at(j) = 1 * keep.at(j) / sum;
}
if (cell_number + 1 == cell_max) {
int get;
// do {
get = rand() % cell_number;
// cout << "in while" << endl;
// } while(get == cell_number - 1);
cell_number--;
cell[get] = cell[cell_number];
}
cell[cell_number].nut_zero_coef = begin_coef.at(cell_type).at(0);
cell[cell_number].type = cell_type;
rep(j, N) {
// cell[cell_number].mol[j] = get_rand_normal(0.2);
cell[cell_number].mol[j] = 0.2;
// cell[cell_number].inside_nut = get_rand_normal(0.2);
cell[cell_number].inside_nut = 0.2;
cell[cell_number].nut_cat = N - 3;
if (j != N - 1) {
cell[cell_number].coef[j][j + 1] = begin_coef.at(cell_type).at(j + 1);
cell[cell_number].catalyst[j][j + 1] = (j - 2 + N) % N;
reversible[cell_number][j + 1] = 0;
}
}
cell[cell_number].size = get_size(cell[cell_number]);
cell[cell_number].init_size = cell[cell_number].size;
cell[cell_number].init_last = cell[cell_number].mol[N - 1];
cell[cell_number].init_last_con = cell[cell_number].mol[N - 1] / cell[cell_number].size;
cell_type++;
cell_number++;
}
pair<Cell, Cell> devide(Cell p)
{
Cell q, r;
q = p;
r = p;
while(1) {
// cout << "dev while" << endl;
q.inside_nut = get_rand_normal(0.5) * p.inside_nut;
if (q.inside_nut >= 0) break;
}
r.inside_nut = p.inside_nut - q.inside_nut;
rep(i, N) {
while(1) {
// cout << "dev whil " << i << " " << p.mol[i] << endl;
q.mol[i] = get_rand_normal(0.5) * p.mol[i];
if (q.mol[i] >= 0) break;
}
r.mol[i] = p.mol[i] - q.mol[i];
}
//sizeを入れておく
q.size = get_size(q);
r.size = get_size(r);
//pairで渡す
pair<Cell, Cell> s = {q, r};
return s;
}
double pop_sum = 0;
void process(int t)
{
box_con = decide_box_nut(t);
//outside系を濃度に変換
prev_outside_nut_con = outside_nut / box_size;
new_outside_nut_con = prev_outside_nut_con;
rep(i, N) {
prev_outside_con[i] = outside[i] / box_size;
new_outside_con[i] = prev_outside_con[i];
}
//loop回してreaction
rep(i, cell_number) {
if (cell[i].size == 0) {
cell[i] = cell[cell_number - 1];
cell_number--;
} else cell[i] = internal(cell[i]);
}
//sizeが2倍以上またはmaxを越えたら分裂、半分になったら消滅
rep(i, cell_number) {
// if (cell[i].size > max_cell_size /* || cell[i].mol[N - 1] > 2 * cell[i].init_last*/) {
if (cell[i].size > 2 * cell[i].init_size) {
devdev++;
if (cell[i].mol[N - 1] > 2 * cell[i].init_last) _count++;
else count_++;
cell_number++;
pair<Cell, Cell> dev = devide(cell[i]);
cell[i] = dev.first;
if (cell_number == cell_max) {
int get;
do {
// cout << "while for dev" << endl;
get = rand() % cell_number;
} while(get == i);
cell_number--;
cell[get] = dev.second;
} else {
cell[cell_number - 1] = dev.second;
}
// } else if (cell[i].mol[N] / cell[i].size < 0.5 * cell[i].init_last_con) {
} else if (cell[i].size < 0.5 * cell[i].init_size) {
cell[i] = cell[cell_number - 1];
cell_number--;
}
}
// cout << "out of dev" << endl;
//outsideの値を更新
outside_nut = new_outside_nut_con * box_size + time_bunkai * (box_con - prev_outside_nut_con) * box_size;
rep(i, N) outside[i] = new_outside_con[i] * box_size;
// cout << "out of outside" << endl;
//それぞれのcelltypeの数をカウント、表示
rep(i, cell_type) a[i] = 0;
rep(i, cell_number) a[cell[i].type]++;
// cout << "start counting a " << cell_number << endl;
cout << t << " ";
rep(i, cell_type) {
if (a[i] == 0) {
take_log_type << a[i] << " ";
continue;
}
cout << setw(4) << a[i] << " ";
take_log_type << a[i] << " ";
}
cout << endl;
take_log_type << endl;
//prevの変換が全て終わってからbox_sizeの値を更新
box_size = get_box_size();
double x = (double)a[0];
double y = (double)cell_number;
if (t >= time_end * 0.2) pop_sum += x / y;
vector<vector<double>> keep8(cell_type);
// cout << cell[0].mol[7] << endl;
rep(i, cell_number) {
if (cell[i].size != 0) keep8[cell[i].type].push_back(cell[i].mol[7] / cell[i].size);
}
rep(i, cell_type) {
vector<double> sum8(cell_type, 0);
rep(j, (int)keep8[i].size()) sum8[i] += keep8[i][j];
if (keep8[i].size() != 0) take_log_inside << sum8[i] / (double)keep8[i].size() << " ";
else take_log_inside << 0 << " ";
}
take_log_inside << endl;
}
int main(void)
{
//randomの種を与える
srand(10);
//run_time回だけ走らせる
rep(l, run_time) {
init();
//time_end秒だけ走らせる
rep(t, time_end) {
devdev = 0;
process(t);
v_sum = 0;
rep(i, cell_number) v_sum += cell[i].size;
take_log_vsum << v_sum / (box_size) << endl;
rep(i, N) {
double sum0 = 0;
double sum2 = 0;
int num0 = 0;
int num2 = 0;
rep(j, cell_number) {
if (cell[j].type == 0) {
sum0 += cell[j].mol[i];
num0++;
}
if (cell[j].type == 16) {
sum2 += cell[j].mol[i];
num2++;
}
}
double get0, get2;
if (num0) get0 = sum0 / (double)num0;
else get0 = 0;
if (num2) get2 = sum2 / (double)num2;
else get2 = 0;
// cout << get0 << " " << get2 << endl;
// if (i == 8) take_log_network << (double)sum0 / (double)num0 << " " << (double)sum2 / (double)num2 << endl;
if (get0) take_log_network << (get0 - get2) / get0 << " ";
else take_log_network << 0 << " ";
}
take_log_network << endl;
// cout << cell[0].size << endl;
take_log_outside << outside_nut / box_size << " ";
rep(i, N) {
take_log_outside << outside[i] / box_size << " ";
}
take_log_outside << endl;
take_log_devdev << devdev << endl;
if (t % 20000 == 1000) evolve();
// if (t == 10000) evolve();
}
}
rep(i, cell_type) {
rep(j, N) {
cout << begin_coef.at(i).at(j) << " ";
take_log_coef << begin_coef.at(i).at(j) << " ";
}
cout << endl;
take_log_coef << endl;
}
rep(i, cell_type) {
if (a[i] == 0) {
continue;
}
cout << i << " " << setw(4) << a[i] << endl;
}
cout << endl;
cout << endl << _count << " " << count_ << endl << endl;
cout << "% = " << pop_sum / ((double)time_end * 0.8) << endl;
return 0;
}