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OpAmp differential amplifier gain: Single-Ended Inputs vs. Double-Ended Input
The difference makes a difference ...
I'll show that the gain factor of an OpAmp differential amplifier will be different between single-ended operation and double-ended operation.
Single-ended operation is characterized by two input voltages, each referenced to ground (on the left side of the image above). In conrast, double-ended operation is characterized by one 'floating' input voltage, i.e. without reference to the ground potential (on the right side of the image above).
Note: The battery symbol has been used just to illustrate that the voltage source is potential-free and does not mean to be necessarily a battery component (it may be a sensor as well, for example).
Differential amplifier driven by single-ended inputs
Fig. 1: Differential amplifier driven by single-ended inputs \(V_{i_+}\) and \(V_{i_-}\)
Fig. 2: The passive network modelling single-ended operation
The feedback-controlled steady-state will be reached as soon as the ground-referenced input voltages equal each other:
$$V_+ = V_-$$
Here, $$V_+$$ and $$V_-$$ drop along different current pathes, driven by $$V_{i_+}$$ and $$V_{i_-}$$, respectively, see Fig. 2.
Differential amplifier driven by double-ended input
Fig. 3: Differential amplifier driven by double-ended input \(V_{d}\)
Fig. 4: The passive network modelling double-ended operation
Again, the feedback-controlled steady-state will be reached as soon as the ground-referenced input voltages equal each other:
\begin{equation}\label{Eq:DiffAmp_Base}
V_+ = V_-
\end{equation}
Perhaps you might expect that double-ended operation is equivalent to single-ended operation, given $$V_d = V_{i_+} - V_{i_-}$$. However, this is not the case.
The crucial difference to single-ended operation is that for double-ended operation $$V_+$$ and $$V_-$$ are not created by means of separate current pathes but rather by a common mesh current back to the floating voltage source $$V_d$$, see Fig. 4. This common mesh current is:
Mentally replacing $$V_d$$ by $$V_{i_+} - V_{i_-}$$ in Eq. \ref{Eq:DiffAmp_DoubleEnded} we see that the result would not equal Eq. \ref{Eq:DiffAmp_SingleEnded}.
Hence, the hypothesis stated at the beginning has been proven: The difference of the input voltages \(V_{i_+} - V_{i_-}\) in single-ended operation will be amplified by another gain factor than a floating voltage \(V_d\) of equal magnitude.
One exeption holds for $$R_1 = R_2 = R_3 = R_4$$.
It should be noticed that the implementation of the OpAmp differential amplifier as an instrumentation amplifier won't be able to operate in a double-ended manner since their built-in voltage follower at the inputs $$V_{i_+}$$ and $$V_{i_-}$$ prevent the mesh current mentioned in Fig. 4 to flow.