diff --git a/x-pack/plugins/fleet/server/services/settings.test.ts b/x-pack/plugins/fleet/server/services/settings.test.ts
index 75712c471f20c1..bec0f737c0bc86 100644
--- a/x-pack/plugins/fleet/server/services/settings.test.ts
+++ b/x-pack/plugins/fleet/server/services/settings.test.ts
@@ -8,7 +8,7 @@
 import { savedObjectsClientMock } from 'src/core/server/mocks';
 
 import { appContextService } from './app_context';
-import { getCloudFleetServersHosts, settingsSetup } from './settings';
+import { getCloudFleetServersHosts, normalizeFleetServerHost, settingsSetup } from './settings';
 
 jest.mock('./app_context');
 
@@ -205,3 +205,22 @@ describe('settingsSetup', () => {
     expect(soClientMock.update).not.toBeCalled();
   });
 });
+
+describe('normalizeFleetServerHost', () => {
+  const scenarios = [
+    { sourceUrl: 'http://test.fr', expectedUrl: 'http://test.fr:80' },
+    { sourceUrl: 'http://test.fr/test/toto', expectedUrl: 'http://test.fr:80/test/toto' },
+    { sourceUrl: 'https://test.fr', expectedUrl: 'https://test.fr:443' },
+    { sourceUrl: 'https://test.fr/test/toto', expectedUrl: 'https://test.fr:443/test/toto' },
+    { sourceUrl: 'https://test.fr:9243', expectedUrl: 'https://test.fr:9243' },
+    { sourceUrl: 'https://test.fr:9243/test/toto', expectedUrl: 'https://test.fr:9243/test/toto' },
+  ];
+
+  for (const scenario of scenarios) {
+    it(`should transform ${scenario.sourceUrl} correctly`, () => {
+      const url = normalizeFleetServerHost(scenario.sourceUrl);
+
+      expect(url).toEqual(scenario.expectedUrl);
+    });
+  }
+});
diff --git a/x-pack/plugins/fleet/server/services/settings.ts b/x-pack/plugins/fleet/server/services/settings.ts
index a03c220eecb83d..6b1a17fc5b0603 100644
--- a/x-pack/plugins/fleet/server/services/settings.ts
+++ b/x-pack/plugins/fleet/server/services/settings.ts
@@ -51,6 +51,30 @@ export async function settingsSetup(soClient: SavedObjectsClientContract) {
   }
 }
 
+function getPortForURL(url: URL) {
+  if (url.port !== '') {
+    return url.port;
+  }
+
+  if (url.protocol === 'http:') {
+    return '80';
+  }
+
+  if (url.protocol === 'https:') {
+    return '443';
+  }
+}
+
+export function normalizeFleetServerHost(host: string) {
+  // Fleet server is not using default port for http|https https://github.com/elastic/beats/issues/25420
+  const fleetServerURL = new URL(host);
+
+  // We are building the URL manualy as url format will not include the port if the port is 80 or 443
+  return `${fleetServerURL.protocol}//${fleetServerURL.hostname}:${getPortForURL(fleetServerURL)}${
+    fleetServerURL.pathname === '/' ? '' : fleetServerURL.pathname
+  }`;
+}
+
 export async function saveSettings(
   soClient: SavedObjectsClientContract,
   newData: Partial<Omit<Settings, 'id'>>
@@ -58,10 +82,15 @@ export async function saveSettings(
   try {
     const settings = await getSettings(soClient);
 
+    const data = { ...newData };
+    if (data.fleet_server_hosts) {
+      data.fleet_server_hosts = data.fleet_server_hosts.map(normalizeFleetServerHost);
+    }
+
     const res = await soClient.update<SettingsSOAttributes>(
       GLOBAL_SETTINGS_SAVED_OBJECT_TYPE,
       settings.id,
-      newData
+      data
     );
 
     return {