diff --git a/x-pack/plugins/fleet/common/constants/epm.ts b/x-pack/plugins/fleet/common/constants/epm.ts
index a1d73b452cf72..2635dbc05399f 100644
--- a/x-pack/plugins/fleet/common/constants/epm.ts
+++ b/x-pack/plugins/fleet/common/constants/epm.ts
@@ -16,6 +16,7 @@ export const FLEET_ENDPOINT_PACKAGE = 'endpoint';
 export const FLEET_APM_PACKAGE = 'apm';
 export const FLEET_SYNTHETICS_PACKAGE = 'synthetics';
 export const FLEET_KUBERNETES_PACKAGE = 'kubernetes';
+export const FLEET_UNIVERSAL_PROFILING_SYMBOLIZER_PACKAGE = 'profiler_symbolizer';
 export const FLEET_CLOUD_SECURITY_POSTURE_PACKAGE = 'cloud_security_posture';
 export const FLEET_CLOUD_SECURITY_POSTURE_KSPM_POLICY_TEMPLATE = 'kspm';
 
diff --git a/x-pack/plugins/fleet/server/services/agent_policies/package_policies_to_agent_permissions.test.ts b/x-pack/plugins/fleet/server/services/agent_policies/package_policies_to_agent_permissions.test.ts
index 1f5ea87c6d6f9..f093b20eaaeb4 100644
--- a/x-pack/plugins/fleet/server/services/agent_policies/package_policies_to_agent_permissions.test.ts
+++ b/x-pack/plugins/fleet/server/services/agent_policies/package_policies_to_agent_permissions.test.ts
@@ -13,6 +13,7 @@ import type { DataStreamMeta } from './package_policies_to_agent_permissions';
 import {
   getDataStreamPrivileges,
   storedPackagePoliciesToAgentPermissions,
+  UNIVERSAL_PROFILING_PERMISSIONS,
 } from './package_policies_to_agent_permissions';
 
 const packageInfoCache = new Map();
@@ -137,6 +138,56 @@ packageInfoCache.set('osquery_manager-0.3.0', {
     },
   },
 });
+packageInfoCache.set('profiler_symbolizer-8.8.0-preview', {
+  format_version: '2.7.0',
+  name: 'profiler_symbolizer',
+  title: 'Universal Profiling Symbolizer',
+  version: '8.8.0-preview',
+  license: 'basic',
+  description:
+    ' Fleet-wide, whole-system, continuous profiling with zero instrumentation. Symbolize native frames.',
+  type: 'integration',
+  release: 'beta',
+  categories: ['monitoring', 'elastic_stack'],
+  icons: [
+    {
+      src: '/img/logo_profiling_symbolizer.svg',
+      title: 'logo symbolizer',
+      size: '32x32',
+      type: 'image/svg+xml',
+    },
+  ],
+  owner: { github: 'elastic/profiling' },
+  data_streams: [],
+  latestVersion: '8.8.0-preview',
+  notice: undefined,
+  status: 'not_installed',
+  assets: {
+    kibana: {
+      csp_rule_template: [],
+      dashboard: [],
+      visualization: [],
+      search: [],
+      index_pattern: [],
+      map: [],
+      lens: [],
+      security_rule: [],
+      ml_module: [],
+      tag: [],
+      osquery_pack_asset: [],
+      osquery_saved_query: [],
+    },
+    elasticsearch: {
+      component_template: [],
+      ingest_pipeline: [],
+      ilm_policy: [],
+      transform: [],
+      index_template: [],
+      data_stream_ilm_policy: [],
+      ml_model: [],
+    },
+  },
+});
 
 describe('storedPackagePoliciesToAgentPermissions()', () => {
   it('Returns `undefined` if there are no package policies', async () => {
@@ -363,6 +414,47 @@ describe('storedPackagePoliciesToAgentPermissions()', () => {
       },
     });
   });
+
+  it('Returns the Universal Profiling permissions for profiler_symbolizer package', async () => {
+    const packagePolicies: PackagePolicy[] = [
+      {
+        id: 'package-policy-uuid-test-123',
+        name: 'test-policy',
+        namespace: '',
+        enabled: true,
+        package: { name: 'profiler_symbolizer', version: '8.8.0-preview', title: 'Test Package' },
+        inputs: [
+          {
+            type: 'pf-elastic-symbolizer',
+            enabled: true,
+            streams: [],
+          },
+        ],
+        created_at: '',
+        updated_at: '',
+        created_by: '',
+        updated_by: '',
+        revision: 1,
+        policy_id: '',
+      },
+    ];
+
+    const permissions = await storedPackagePoliciesToAgentPermissions(
+      packageInfoCache,
+      packagePolicies
+    );
+
+    expect(permissions).toMatchObject({
+      'package-policy-uuid-test-123': {
+        indices: [
+          {
+            names: ['profiling-*'],
+            privileges: UNIVERSAL_PROFILING_PERMISSIONS,
+          },
+        ],
+      },
+    });
+  });
 });
 
 describe('getDataStreamPrivileges()', () => {
diff --git a/x-pack/plugins/fleet/server/services/agent_policies/package_policies_to_agent_permissions.ts b/x-pack/plugins/fleet/server/services/agent_policies/package_policies_to_agent_permissions.ts
index 02c44024421ce..f8cd73901e0d7 100644
--- a/x-pack/plugins/fleet/server/services/agent_policies/package_policies_to_agent_permissions.ts
+++ b/x-pack/plugins/fleet/server/services/agent_policies/package_policies_to_agent_permissions.ts
@@ -5,6 +5,8 @@
  * 2.0.
  */
 
+import { FLEET_UNIVERSAL_PROFILING_SYMBOLIZER_PACKAGE } from '../../../common/constants';
+
 import { getNormalizedDataStreams } from '../../../common/services';
 
 import type {
@@ -19,6 +21,16 @@ import { pkgToPkgKey } from '../epm/registry';
 
 export const DEFAULT_CLUSTER_PERMISSIONS = ['monitor'];
 
+export const UNIVERSAL_PROFILING_PERMISSIONS = [
+  'auto_configure',
+  'read',
+  'create_doc',
+  'create',
+  'write',
+  'index',
+  'view_index_metadata',
+];
+
 export async function storedPackagePoliciesToAgentPermissions(
   packageInfoCache: Map<string, PackageInfo>,
   packagePolicies?: PackagePolicy[]
@@ -42,6 +54,12 @@ export async function storedPackagePoliciesToAgentPermissions(
 
       const pkg = packageInfoCache.get(pkgToPkgKey(packagePolicy.package))!;
 
+      // Special handling for Universal Profiling packages, as it does not use data streams _only_,
+      // but also indices that do not adhere to the convention.
+      if (pkg.name === FLEET_UNIVERSAL_PROFILING_SYMBOLIZER_PACKAGE) {
+        return Promise.resolve(universalProfilingPermissions(packagePolicy.id));
+      }
+
       const dataStreams = getNormalizedDataStreams(pkg);
       if (!dataStreams || dataStreams.length === 0) {
         return [packagePolicy.name, undefined];
@@ -175,3 +193,18 @@ export function getDataStreamPrivileges(dataStream: DataStreamMeta, namespace: s
     privileges,
   };
 }
+
+async function universalProfilingPermissions(packagePolicyId: string): Promise<[string, any]> {
+  const profilingIndexPattern = 'profiling-*';
+  return [
+    packagePolicyId,
+    {
+      indices: [
+        {
+          names: [profilingIndexPattern],
+          privileges: UNIVERSAL_PROFILING_PERMISSIONS,
+        },
+      ],
+    },
+  ];
+}