diff --git a/packages/core/chrome/core-chrome-browser-internal/src/ui/header/__snapshots__/header.test.tsx.snap b/packages/core/chrome/core-chrome-browser-internal/src/ui/header/__snapshots__/header.test.tsx.snap
index d86194ac7dbaf7..37aeb88feefa80 100644
--- a/packages/core/chrome/core-chrome-browser-internal/src/ui/header/__snapshots__/header.test.tsx.snap
+++ b/packages/core/chrome/core-chrome-browser-internal/src/ui/header/__snapshots__/header.test.tsx.snap
@@ -20,6 +20,21 @@ Array [
       test - Elastic
     </div>
   </div>,
+  <button
+    class="euiSkipLink emotion-euiButtonDisplay-s-defaultMinWidth-s-fill-primary-euiSkipLink-fixed-euiScreenReaderOnly"
+    tabindex="0"
+    type="button"
+  >
+    <span
+      class="emotion-euiButtonDisplayContent"
+    >
+      <span
+        class="eui-textTruncate"
+      >
+        Skip to main content
+      </span>
+    </span>
+  </button>,
   <header
     class="hide-for-sharing headerGlobalNav"
     data-test-subj="headerGlobalNav"
diff --git a/packages/core/chrome/core-chrome-browser-internal/src/ui/header/__snapshots__/screen_reader_a11y.test.tsx.snap b/packages/core/chrome/core-chrome-browser-internal/src/ui/header/__snapshots__/screen_reader_a11y.test.tsx.snap
index f10087a2eb2e0f..ef68f5535927b1 100644
--- a/packages/core/chrome/core-chrome-browser-internal/src/ui/header/__snapshots__/screen_reader_a11y.test.tsx.snap
+++ b/packages/core/chrome/core-chrome-browser-internal/src/ui/header/__snapshots__/screen_reader_a11y.test.tsx.snap
@@ -315,3 +315,21 @@ exports[`ScreenReaderRouteAnnouncements renders 1`] = `
   </EuiScreenReaderLive>
 </ScreenReaderRouteAnnouncements>
 `;
+
+exports[`SkipToMainContent renders 1`] = `
+<button
+  class="euiSkipLink emotion-euiButtonDisplay-s-defaultMinWidth-s-fill-primary-euiSkipLink-fixed-euiScreenReaderOnly"
+  tabindex="0"
+  type="button"
+>
+  <span
+    class="emotion-euiButtonDisplayContent"
+  >
+    <span
+      class="eui-textTruncate"
+    >
+      Skip to main content
+    </span>
+  </span>
+</button>
+`;
diff --git a/packages/core/chrome/core-chrome-browser-internal/src/ui/header/header.tsx b/packages/core/chrome/core-chrome-browser-internal/src/ui/header/header.tsx
index 227a94a208ca34..5449ee34bb662b 100644
--- a/packages/core/chrome/core-chrome-browser-internal/src/ui/header/header.tsx
+++ b/packages/core/chrome/core-chrome-browser-internal/src/ui/header/header.tsx
@@ -46,7 +46,7 @@ import { HeaderActionMenu } from './header_action_menu';
 import { HeaderExtension } from './header_extension';
 import { HeaderTopBanner } from './header_top_banner';
 import { HeaderMenuButton } from './header_menu_button';
-import { ScreenReaderRouteAnnouncements } from './screen_reader_a11y';
+import { ScreenReaderRouteAnnouncements, SkipToMainContent } from './screen_reader_a11y';
 
 export interface HeaderProps {
   kibanaVersion: string;
@@ -114,6 +114,7 @@ export function Header({
         customBranding$={customBranding$}
         appId$={application.currentAppId$}
       />
+      <SkipToMainContent />
 
       <HeaderTopBanner headerBanner$={observables.headerBanner$} />
       <header className={className} data-test-subj="headerGlobalNav">
diff --git a/packages/core/chrome/core-chrome-browser-internal/src/ui/header/screen_reader_a11y.test.tsx b/packages/core/chrome/core-chrome-browser-internal/src/ui/header/screen_reader_a11y.test.tsx
index 3dfc25c93c25ac..b468eefd51d795 100644
--- a/packages/core/chrome/core-chrome-browser-internal/src/ui/header/screen_reader_a11y.test.tsx
+++ b/packages/core/chrome/core-chrome-browser-internal/src/ui/header/screen_reader_a11y.test.tsx
@@ -9,8 +9,8 @@
 import React from 'react';
 import { BehaviorSubject } from 'rxjs';
 import { mountWithIntl } from '@kbn/test-jest-helpers';
-import { ScreenReaderRouteAnnouncements } from './screen_reader_a11y';
-import { mount } from 'enzyme';
+import { ScreenReaderRouteAnnouncements, SkipToMainContent } from './screen_reader_a11y';
+import { mount, render } from 'enzyme';
 
 describe('ScreenReaderRouteAnnouncements', () => {
   it('renders', () => {
@@ -67,3 +67,10 @@ describe('ScreenReaderRouteAnnouncements', () => {
     ).toBeTruthy();
   });
 });
+
+describe('SkipToMainContent', () => {
+  it('renders', () => {
+    const component = render(<SkipToMainContent />);
+    expect(component).toMatchSnapshot();
+  });
+});
diff --git a/packages/core/chrome/core-chrome-browser-internal/src/ui/header/screen_reader_a11y.tsx b/packages/core/chrome/core-chrome-browser-internal/src/ui/header/screen_reader_a11y.tsx
index 811da523414172..f879e896297dce 100644
--- a/packages/core/chrome/core-chrome-browser-internal/src/ui/header/screen_reader_a11y.tsx
+++ b/packages/core/chrome/core-chrome-browser-internal/src/ui/header/screen_reader_a11y.tsx
@@ -8,7 +8,8 @@
 
 import React, { FC, useState, useEffect } from 'react';
 import useObservable from 'react-use/lib/useObservable';
-import { EuiScreenReaderLive } from '@elastic/eui';
+import { EuiScreenReaderLive, EuiSkipLink } from '@elastic/eui';
+import { i18n } from '@kbn/i18n';
 
 import type { InternalApplicationStart } from '@kbn/core-application-browser-internal';
 import type { HeaderProps } from './header';
@@ -56,3 +57,25 @@ export const ScreenReaderRouteAnnouncements: FC<{
     </EuiScreenReaderLive>
   );
 };
+
+const fallbackContentQueries = [
+  'main', // Ideal target for all plugins using KibanaPageTemplate
+  '[role="main"]', // Fallback for plugins using deprecated EuiPageContent
+  '.kbnAppWrapper', // Last-ditch fallback for all plugins regardless of page template
+];
+
+export const SkipToMainContent = () => {
+  return (
+    <EuiSkipLink
+      position="fixed"
+      destinationId="" // TODO: Potentially allow this to be customizable per-plugin
+      fallbackDestination={fallbackContentQueries}
+      overrideLinkBehavior
+      href="" // Render a button
+    >
+      {i18n.translate('core.ui.skipToMainButton', {
+        defaultMessage: 'Skip to main content',
+      })}
+    </EuiSkipLink>
+  );
+};