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Copy pathNM_153603.gb
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NM_153603.gb
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LOCUS NM_153603 2935 bp mRNA linear PRI 13-NOV-2023
DEFINITION Homo sapiens component of oligomeric golgi complex 7 (COG7), mRNA.
ACCESSION NM_153603
VERSION NM_153603.4
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2935)
AUTHORS Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
MA.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 2 (bases 1 to 2935)
AUTHORS Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
TITLE Extensive disruption of protein interactions by genetic variants
across the allele frequency spectrum in human populations
JOURNAL Nat Commun 10 (1), 4141 (2019)
PUBMED 31515488
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2935)
AUTHORS Climer LK, Pokrovskaya ID, Blackburn JB and Lupashin VV.
TITLE Membrane detachment is not essential for COG complex function
JOURNAL Mol Biol Cell 29 (8), 964-974 (2018)
PUBMED 29467253
REMARK GeneRIF: TMEM-COG4, COG7 and COG8 subunits restore endogenous COG
localization to the Golgi membranes
REFERENCE 4 (bases 1 to 2935)
AUTHORS Bailey Blackburn J, Pokrovskaya I, Fisher P, Ungar D and Lupashin
VV.
TITLE COG Complex Complexities: Detailed Characterization of a Complete
Set of HEK293T Cells Lacking Individual COG Subunits
JOURNAL Front Cell Dev Biol 4, 23 (2016)
PUBMED 27066481
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 2935)
AUTHORS Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T,
Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg
BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Wanamaker
SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan
G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K,
Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE,
Iakoucheva LM, Xia Y and Vidal M.
TITLE Widespread Expansion of Protein Interaction Capabilities by
Alternative Splicing
JOURNAL Cell 164 (4), 805-817 (2016)
PUBMED 26871637
REFERENCE 6 (bases 1 to 2935)
AUTHORS Loh E and Hong W.
TITLE The binary interacting network of the conserved oligomeric Golgi
tethering complex
JOURNAL J Biol Chem 279 (23), 24640-24648 (2004)
PUBMED 15047703
REFERENCE 7 (bases 1 to 2935)
AUTHORS Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J,
Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D,
Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS,
Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M,
Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J,
Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods
K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard
A, Wood WI, Godowski P and Gray A.
TITLE The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins:
a bioinformatics assessment
JOURNAL Genome Res 13 (10), 2265-2270 (2003)
PUBMED 12975309
REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE 8 (bases 1 to 2935)
AUTHORS Loh E and Hong W.
TITLE Sec34 is implicated in traffic from the endoplasmic reticulum to
the Golgi and exists in a complex with GTC-90 and ldlBp
JOURNAL J Biol Chem 277 (24), 21955-21961 (2002)
PUBMED 11929878
REFERENCE 9 (bases 1 to 2935)
AUTHORS Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE,
Heuser JE, Krieger M and Waters MG.
TITLE Characterization of a mammalian Golgi-localized protein complex,
COG, that is required for normal Golgi morphology and function
JOURNAL J Cell Biol 157 (3), 405-415 (2002)
PUBMED 11980916
REFERENCE 10 (bases 1 to 2935)
AUTHORS Sparks,S.E. and Krasnewich,D.M.
TITLE Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
Overview
JOURNAL (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH,
Gripp KW and Amemiya A (Eds.);
GENEREVIEWS(R);
(1993)
PUBMED 20301507
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB444997.1, BC037563.1 and
R54036.1.
This sequence is a reference standard in the RefSeqGene project.
On Nov 24, 2018 this sequence version replaced NM_153603.3.
Summary: The protein encoded by this gene resides in the golgi, and
constitutes one of the 8 subunits of the conserved oligomeric Golgi
(COG) complex, which is required for normal golgi morphology and
localization. Mutations in this gene are associated with the
congenital disorder of glycosylation type IIe.[provided by RefSeq,
May 2010].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC037563.1, SRR1803615.220993.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000307149.10/ ENSP00000305442.5
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-86 DB444997.1 11-96
87-2801 BC037563.1 78-2792
2802-2935 R54036.1 7-140 c
FEATURES Location/Qualifiers
source 1..2935
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p12.2"
gene 1..2935
/gene="COG7"
/gene_synonym="CDG2E"
/note="component of oligomeric golgi complex 7"
/db_xref="GeneID:91949"
/db_xref="HGNC:HGNC:18622"
/db_xref="MIM:606978"
exon 1..364
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
misc_feature 181..183
/gene="COG7"
/gene_synonym="CDG2E"
/note="upstream in-frame stop codon"
CDS 196..2508
/gene="COG7"
/gene_synonym="CDG2E"
/note="COG complex subunit 7"
/codon_start=1
/product="conserved oligomeric Golgi complex subunit 7"
/protein_id="NP_705831.1"
/db_xref="CCDS:CCDS10610.1"
/db_xref="GeneID:91949"
/db_xref="HGNC:HGNC:18622"
/db_xref="MIM:606978"
/translation="MDFSKFLADDFDVKEWINAAFRAGSKEAASGKADGHAATLVMKL
QLFIQEVNHAVEETSHQALQNMPKVLRDVEALKQEASFLKEQMILVKEDIKKFEQDTS
QSMQVLVEIDQVKSRMQLAAESLQEADKWSTLSADIEETFKTQDIAVISAKLTGMQNS
LMMLVDTPDYSEKCVHLEALKNRLEALASPQIVAAFTSQAVDQSKVFVKVFTEIDRMP
QLLAYYYKCHKVQLLAAWQELCQSDLSLDRQLTGLYDALLGAWHTQIQWATQVFQKPH
EVVMVLLIQTLGALMPSLPSCLSNGVERAGPEQELTRLLEFYDATAHFAKGLEMALLP
HLHEHNLVKVTELVDAVYDPYKPYQLKYGDMEESNLLIQMSAVPLEHGEVIDCVQELS
HSVNKLFGLASAAVDRCVRFTNGLGTCGLLSALKSLFAKYVSDFTSTLQSIRKKCKLD
HIPPNSLFQEDWTAFQNSIRIIATCGELLRHCGDFEQQLANRILSTAGKYLSDSCSPR
SLAGFQESILTDKKNSAKNPWQEYNYLQKDNPAEYASLMEILYTLKEKGSSNHNLLAA
PRAALTRLNQQAHQLAFDSVFLRIKQQLLLISKMDSWNTAGIGETLTDELPAFSLTPL
EYISNIGQYIMSLPLNLEPFVTQEDSALELALHAGKLPFPPEQGDELPELDNMADNWL
GSIARATMQTYCDAILQIPELSPHSAKQLATDIDYLINVMDALGLQPSRTLQHIVTLL
KTRPEDYRQVSKGLPRRLATTVATMRSVNY"
exon 365..513
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 514..630
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 631..799
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 800..882
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 883..1005
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 1006..1204
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 1205..1332
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 1333..1487
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 1488..1604
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 1605..1670
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 1671..1857
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 1858..1998
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 1999..2082
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 2083..2197
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 2198..2341
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
exon 2342..2935
/gene="COG7"
/gene_synonym="CDG2E"
/inference="alignment:Splign:2.1.0"
regulatory 2911..2916
/regulatory_class="polyA_signal_sequence"
/gene="COG7"
/gene_synonym="CDG2E"
/note="hexamer: AATAAA"
polyA_site 2935
/gene="COG7"
/gene_synonym="CDG2E"
/note="major polyA site"
ORIGIN
1 gagggtcatt cccagccgca aactgagtgc gctgagcggg gaagcgcaaa ggggcaagtt
61 acccgtcctg gcgtttctgg ggttcgcctc ggaggctagc ctcggtgctc tcgcaggctc
121 gctcgcttct gcatccccgt tgccgcccgg agccaactct taagttctgg acgccaggcc
181 tgaggcagtt ccgccatgga cttctccaag ttcctggcag acgacttcga cgtgaaggag
241 tggatcaatg cggccttcag ggccggctcc aaggaggcgg cgtccgggaa ggcggatggc
301 cacgcagcca ccctggtgat gaagctgcag ctgttcatcc aagaggtgaa ccacgccgtg
361 gaggaaacaa gtcaccaagc tctccagaac atgcccaaag tgctccgtga tgttgaagcc
421 ctaaaacagg aggcatcttt cctgaaagaa cagatgattc ttgtcaagga ggacattaaa
481 aaatttgaac aggacacatc tcaatccatg caggtgttgg tagaaattga ccaagtgaag
541 tccagaatgc aacttgctgc cgaatctctt caggaagcag ataagtggag cacgttgagc
601 gccgatattg aggagacatt taagactcag gacatagctg tgatttctgc caagctaaca
661 ggtatgcaga acagcttaat gatgcttgtt gatacaccag actactcaga aaagtgtgtg
721 cacttggagg cactgaagaa caggctggag gccctagcca gtccacagat tgtagcggca
781 ttcacctctc aggctgtaga tcagtccaaa gtgtttgtga aggtgtttac tgaaattgac
841 cggatgcccc agctcctggc ctactactac aagtgtcaca aggtgcagct tttagcagcc
901 tggcaagagc tgtgtcaaag tgacctatcc ctggaccggc agcttaccgg actctatgat
961 gccttgcttg gtgcttggca cacacaaatc cagtgggcta cacaggtttt ccagaagccc
1021 cacgaggtgg taatggtgct gctgattcag accctggggg ccctcatgcc ctcgctgccc
1081 tcctgcctca gcaacggcgt ggagagggca gggcccgagc aggagctcac caggctgctg
1141 gagttctacg acgccaccgc ccacttcgcc aagggcttgg agatggcact gctcccccac
1201 ctacatgaac acaatctggt aaaagtcacg gagctggtgg atgctgtgta tgatccatac
1261 aaaccctacc agctgaagta tggcgacatg gaagagagca acctcctcat ccagatgagt
1321 gctgtgcctc tggagcatgg ggaagtgatt gactgtgtgc aggagctgag ccactccgtg
1381 aacaagctgt ttggtctggc gtctgcagcc gttgacagat gcgtcagatt caccaatggc
1441 ctggggacct gcggcctgtt gtcagccctg aaatccctct ttgccaagta tgtgtctgat
1501 ttcaccagca ctctccagtc catacgaaag aagtgcaaac tggaccacat tcctcccaac
1561 tccctcttcc aggaagattg gacggctttt cagaactcca ttaggataat agccacctgt
1621 ggagagcttt tgcggcattg tggggacttc gagcagcagc tagccaacag gattttgtcc
1681 acagctggga agtatctatc tgattcctgc agcccccgga gcctggctgg ttttcaggag
1741 agcatcttga cagacaagaa gaactctgcc aagaacccat ggcaagaata taattacctc
1801 cagaaagata accctgctga atatgccagt ttaatggaaa tactttatac ccttaaggaa
1861 aaagggtcaa gcaaccacaa cctgctggct gcacctcgag cagcgctgac tcggcttaac
1921 cagcaggccc accagctggc tttcgattcc gtgttcctgc gcatcaaaca acagctgttg
1981 cttatttcga agatggacag ctggaatacg gctggcatcg gagaaaccct cacagatgaa
2041 ctgcccgcct ttagtctcac ccctctcgag tacatcagca acatcgggca gtacatcatg
2101 tccctccccc tgaatcttga gccatttgtg actcaggagg actctgcctt agagttggca
2161 ttgcacgctg gaaagctgcc atttcctcct gagcaggggg atgaattgcc cgagctggac
2221 aacatggctg acaactggct gggctcgatc gccagagcca caatgcagac ctactgtgat
2281 gcgatcctac agatccctga gctgagccca cactctgcca agcagctggc cactgacatc
2341 gactatctga tcaacgtgat ggatgccctg ggcctgcagc cgtcccgcac cctccagcac
2401 atcgtgacgc tactgaagac caggcctgag gactatagac aggtcagcaa aggcctgccc
2461 cgtcgcctgg ccaccaccgt ggccaccatg cggagtgtga attactgacc ccaccacaca
2521 ccggaccacc aagagagcca gggctgctgt ttcgcgactc accagcacag atttgctcag
2581 aaactctgcc caagattggg cagaagttac tttaaaaaga cttggttcag ctggtcacgg
2641 tggctcacgc ctgtaatccc agcactttgg gaggccaagc cagatggatc atgaagccag
2701 gagttcgaga ccagcctgac caacatggtg aaaccccatc tctactaaaa atacaaaaat
2761 taacagcaga gcgagactct gtctcaaaaa aaaaaaaaaa aaagacttgg ttcatttgta
2821 taatcaaaaa gagttgtaaa ttaaagatgt attatttatc agagaagact ttttagataa
2881 tttttttaaa ggatcagatc ttgaaaatgg aataaataac tactgtgaaa tgcaa
//