diff --git a/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs b/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs
index eb7ec19f7a4b8..078a0a82206e8 100644
--- a/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs
+++ b/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs
@@ -380,6 +380,7 @@ public void ReflectionOnlyGetAssemblies()
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/75302", typeof(PlatformDetection), nameof(PlatformDetection.IsNativeAot), nameof(PlatformDetection.IsArm64Process))]
         [SkipOnPlatform(TestPlatforms.Browser | TestPlatforms.iOS | TestPlatforms.tvOS, "Throws PNSE")]
         public void MonitoringIsEnabled()
         {