diff --git a/eng/native/configurecompiler.cmake b/eng/native/configurecompiler.cmake
index 0c9138ba02905..b3238be0d8ac7 100644
--- a/eng/native/configurecompiler.cmake
+++ b/eng/native/configurecompiler.cmake
@@ -384,6 +384,17 @@ if (CLR_CMAKE_HOST_UNIX)
   # using twos-complement representation (this is normally undefined according to the C++ spec).
   add_compile_options(-fwrapv)
 
+  if(CLR_CMAKE_HOST_OSX OR CLR_CMAKE_HOST_MACCATALYST OR CLR_CMAKE_HOST_IOS OR CLR_CMAKE_HOST_TVOS)
+    # Clang will by default emit objc_msgSend stubs in Xcode 14, which ld from earlier Xcodes doesn't understand.
+    # We disable this by passing -fno-objc-msgsend-selector-stubs to clang.
+    # We can probably remove this flag once we require developers to use Xcode 14.
+    # Ref: https://github.com/xamarin/xamarin-macios/issues/16223
+    check_c_compiler_flag(-fno-objc-msgsend-selector-stubs COMPILER_SUPPORTS_FNO_OBJC_MSGSEND_SELECTOR_STUBS)
+    if(COMPILER_SUPPORTS_FNO_OBJC_MSGSEND_SELECTOR_STUBS)
+      set(CLR_CMAKE_COMMON_OBJC_FLAGS "${CLR_CMAKE_COMMON_OBJC_FLAGS} -fno-objc-msgsend-selector-stubs")
+    endif()
+  endif()
+
   if(CLR_CMAKE_HOST_OSX OR CLR_CMAKE_HOST_MACCATALYST)
     # We cannot enable "stack-protector-strong" on OS X due to a bug in clang compiler (current version 7.0.2)
     add_compile_options(-fstack-protector)
diff --git a/src/mono/CMakeLists.txt b/src/mono/CMakeLists.txt
index 6dbf542183bcd..b80b1b6dbde1a 100644
--- a/src/mono/CMakeLists.txt
+++ b/src/mono/CMakeLists.txt
@@ -899,6 +899,14 @@ if(HOST_IOS OR HOST_ANDROID OR HOST_MACCAT)
 else()
   set(DISABLE_DLLMAP 1)
 endif()
+
+if(TARGET_DARWIN)
+  check_c_compiler_flag(-fno-objc-msgsend-selector-stubs COMPILER_SUPPORTS_FNO_OBJC_MSGSEND_SELECTOR_STUBS)
+  if(COMPILER_SUPPORTS_FNO_OBJC_MSGSEND_SELECTOR_STUBS)
+    set(CLR_CMAKE_COMMON_OBJC_FLAGS "${CLR_CMAKE_COMMON_OBJC_FLAGS} -fno-objc-msgsend-selector-stubs")
+  endif()
+endif()
+
 ### End of OS specific checks
 
 include_directories("${CLR_SRC_NATIVE_DIR}")
diff --git a/src/mono/mono/mini/CMakeLists.txt b/src/mono/mono/mini/CMakeLists.txt
index 9e74fd9e16fb4..4d260ebb0f598 100644
--- a/src/mono/mono/mini/CMakeLists.txt
+++ b/src/mono/mono/mini/CMakeLists.txt
@@ -78,6 +78,9 @@ if(HAVE_SYS_ICU AND NOT HOST_WASI)
   addprefix(icu_shim_sources "${ICU_SHIM_PATH}" "${icu_shim_sources_base}")
   set_source_files_properties(${icu_shim_sources} PROPERTIES COMPILE_DEFINITIONS OSX_ICU_LIBRARY_PATH="${OSX_ICU_LIBRARY_PATH}")
   set_source_files_properties(${icu_shim_sources} PROPERTIES COMPILE_FLAGS "-I\"${ICU_INCLUDEDIR}\" -I\"${CLR_SRC_NATIVE_DIR}/libs/System.Globalization.Native/\" -I\"${CLR_SRC_NATIVE_DIR}/libs/Common/\" ${ICU_FLAGS}")
+  if(TARGET_DARWIN)
+    set_property(SOURCE "${ICU_SHIM_PATH}/pal_locale.m" APPEND_STRING PROPERTY COMPILE_FLAGS "${CLR_CMAKE_COMMON_OBJC_FLAGS}")
+  endif()
   if(TARGET_WIN32)
       set_source_files_properties(${icu_shim_sources} PROPERTIES LANGUAGE CXX)
   endif()
diff --git a/src/native/libs/System.Globalization.Native/CMakeLists.txt b/src/native/libs/System.Globalization.Native/CMakeLists.txt
index a41e66cacd310..205e2f60a0f8a 100644
--- a/src/native/libs/System.Globalization.Native/CMakeLists.txt
+++ b/src/native/libs/System.Globalization.Native/CMakeLists.txt
@@ -62,6 +62,7 @@ set(NATIVEGLOBALIZATION_SOURCES
 
 if (CLR_CMAKE_TARGET_OSX OR CLR_CMAKE_TARGET_MACCATALYST OR CLR_CMAKE_TARGET_IOS OR CLR_CMAKE_TARGET_TVOS)
     set(NATIVEGLOBALIZATION_SOURCES ${NATIVEGLOBALIZATION_SOURCES} pal_locale.m)
+    set_source_files_properties(pal_locale.m PROPERTIES COMPILE_FLAGS "${CLR_CMAKE_COMMON_OBJC_FLAGS}")
 endif()
 
 # time zone names are filtered out of icu data for the browser and associated functionality is disabled
diff --git a/src/native/libs/System.Native/CMakeLists.txt b/src/native/libs/System.Native/CMakeLists.txt
index e6ecf3514fdeb..ff27d14dc5275 100644
--- a/src/native/libs/System.Native/CMakeLists.txt
+++ b/src/native/libs/System.Native/CMakeLists.txt
@@ -39,13 +39,14 @@ set(NATIVE_SOURCES
 
 if (CLR_CMAKE_TARGET_OSX OR CLR_CMAKE_TARGET_MACCATALYST OR CLR_CMAKE_TARGET_IOS OR CLR_CMAKE_TARGET_TVOS)
     list (APPEND NATIVE_SOURCES pal_autoreleasepool.m)
-    set_source_files_properties(pal_autoreleasepool.m PROPERTIES COMPILE_FLAGS -fno-objc-arc)
+    set_source_files_properties(pal_autoreleasepool.m PROPERTIES COMPILE_FLAGS "-fno-objc-arc ${CLR_CMAKE_COMMON_OBJC_FLAGS}")
 else()
     list (APPEND NATIVE_SOURCES pal_autoreleasepool.c)
 endif()
 
 if (CLR_CMAKE_TARGET_MACCATALYST OR CLR_CMAKE_TARGET_IOS OR CLR_CMAKE_TARGET_TVOS)
     list (APPEND NATIVE_SOURCES pal_environment.m)
+    set_source_files_properties(pal_environment.m PROPERTIES COMPILE_FLAGS "${CLR_CMAKE_COMMON_OBJC_FLAGS}")
 else()
     list (APPEND NATIVE_SOURCES pal_environment.c)
 endif()
@@ -53,12 +54,14 @@ endif()
 if (CLR_CMAKE_TARGET_MACCATALYST OR CLR_CMAKE_TARGET_IOS OR CLR_CMAKE_TARGET_TVOS)
     set(NATIVE_SOURCES ${NATIVE_SOURCES}
         pal_datetime.m)
+    set_source_files_properties(pal_datetime.m PROPERTIES COMPILE_FLAGS "${CLR_CMAKE_COMMON_OBJC_FLAGS}")
 endif()
 
 if (CLR_CMAKE_TARGET_MACCATALYST OR CLR_CMAKE_TARGET_IOS OR CLR_CMAKE_TARGET_TVOS)
     set(NATIVE_SOURCES ${NATIVE_SOURCES}
         pal_log.m
         pal_searchpath.m)
+    set_source_files_properties(pal_log.m pal_searchpath.m PROPERTIES COMPILE_FLAGS "${CLR_CMAKE_COMMON_OBJC_FLAGS}")
 else ()
     list (APPEND NATIVE_SOURCES
         pal_searchpath.c
@@ -69,6 +72,7 @@ endif ()
 if (CLR_CMAKE_TARGET_MACCATALYST)
     set(NATIVE_SOURCES ${NATIVE_SOURCES}
         pal_iossupportversion.m)
+    set_source_files_properties(pal_iossupportversion.m PROPERTIES COMPILE_FLAGS "${CLR_CMAKE_COMMON_OBJC_FLAGS}")
 else ()
     list (APPEND NATIVE_SOURCES
         pal_iossupportversion.c)