diff --git a/app/javascript/mastodon/components/status.jsx b/app/javascript/mastodon/components/status.jsx
index 95ea53521f6190..669eb22cb629ad 100644
--- a/app/javascript/mastodon/components/status.jsx
+++ b/app/javascript/mastodon/components/status.jsx
@@ -3,6 +3,8 @@ import PropTypes from 'prop-types';
 import { injectIntl, defineMessages, FormattedMessage } from 'react-intl';
 
 import classNames from 'classnames';
+import { Link } from 'react-router-dom';
+
 
 import ImmutablePropTypes from 'react-immutable-proptypes';
 import ImmutablePureComponent from 'react-immutable-pure-component';
@@ -164,32 +166,18 @@ class Status extends ImmutablePureComponent {
   };
 
   handleClick = e => {
-    if (e && (e.button !== 0 || e.ctrlKey || e.metaKey)) {
-      return;
-    }
-
-    if (e) {
-      e.preventDefault();
-    }
-
-    this.handleHotkeyOpen();
+    e.preventDefault();
+    this.handleHotkeyOpen(e);
   };
 
-  handlePrependAccountClick = e => {
-    this.handleAccountClick(e, false);
-  };
+  handleMouseUp = e => {
+    // Only handle clicks on the empty space above the content
 
-  handleAccountClick = (e, proper = true) => {
-    if (e && (e.button !== 0 || e.ctrlKey || e.metaKey))  {
+    if (e.target !== e.currentTarget) {
       return;
     }
 
-    if (e) {
-      e.preventDefault();
-      e.stopPropagation();
-    }
-
-    this._openProfile(proper);
+    this.handleClick(e);
   };
 
   handleExpandedToggle = () => {
@@ -287,7 +275,7 @@ class Status extends ImmutablePureComponent {
     this.props.onMention(this._properStatus().get('account'));
   };
 
-  handleHotkeyOpen = () => {
+  handleHotkeyOpen = (e) => {
     if (this.props.onClick) {
       this.props.onClick();
       return;
@@ -300,7 +288,13 @@ class Status extends ImmutablePureComponent {
       return;
     }
 
-    history.push(`/@${status.getIn(['account', 'acct'])}/${status.get('id')}`);
+    const path = `/@${status.getIn(['account', 'acct'])}/${status.get('id')}`;
+
+    if (e?.button === 0 && !(e?.ctrlKey || e?.metaKey)) {
+      history.push(path);
+    } else if (e?.button === 1 || (e?.button === 0 && (e?.ctrlKey || e?.metaKey))) {
+      window.open(path, '_blank', 'noreferrer noopener');
+    }
   };
 
   handleHotkeyOpenProfile = () => {
@@ -412,7 +406,7 @@ class Status extends ImmutablePureComponent {
       prepend = (
         <div className='status__prepend'>
           <div className='status__prepend__icon'><Icon id='retweet' icon={RepeatIcon} /></div>
-          <FormattedMessage id='status.reblogged_by' defaultMessage='{name} boosted' values={{ name: <a onClick={this.handlePrependAccountClick} data-id={status.getIn(['account', 'id'])} data-hover-card-account={status.getIn(['account', 'id'])} href={`/@${status.getIn(['account', 'acct'])}`} className='status__display-name muted'><bdi><strong dangerouslySetInnerHTML={display_name_html} /></bdi></a> }} />
+          <FormattedMessage id='status.reblogged_by' defaultMessage='{name} boosted' values={{ name: <Link data-id={status.getIn(['account', 'id'])} data-hover-card-account={status.getIn(['account', 'id'])} to={`/@${status.getIn(['account', 'acct'])}`} className='status__display-name muted'><bdi><strong dangerouslySetInnerHTML={display_name_html} /></bdi></Link> }} />
         </div>
       );
 
@@ -550,20 +544,19 @@ class Status extends ImmutablePureComponent {
           <div className={classNames('status', `status-${status.get('visibility')}`, { 'status-reply': !!status.get('in_reply_to_id'), 'status--in-thread': !!rootId, 'status--first-in-thread': previousId && (!connectUp || connectToRoot), muted: this.props.muted })} data-id={status.get('id')}>
             {(connectReply || connectUp || connectToRoot) && <div className={classNames('status__line', { 'status__line--full': connectReply, 'status__line--first': !status.get('in_reply_to_id') && !connectToRoot })} />}
 
-            {/* eslint-disable-next-line jsx-a11y/no-static-element-interactions */}
-            <div onClick={this.handleClick} className='status__info'>
-              <a href={`/@${status.getIn(['account', 'acct'])}/${status.get('id')}`} className='status__relative-time' target='_blank' rel='noopener noreferrer'>
+            <div onMouseUp={this.handleMouseUp} className='status__info'>
+              <Link to={`/@${status.getIn(['account', 'acct'])}/${status.get('id')}`} className='status__relative-time'>
                 <span className='status__visibility-icon'><VisibilityIcon visibility={status.get('visibility')} /></span>
                 <RelativeTimestamp timestamp={status.get('created_at')} />{status.get('edited_at') && <abbr title={intl.formatMessage(messages.edited, { date: intl.formatDate(status.get('edited_at'), { year: 'numeric', month: 'short', day: '2-digit', hour: '2-digit', minute: '2-digit' }) })}> *</abbr>}
-              </a>
+              </Link>
 
-              <a onClick={this.handleAccountClick} href={`/@${status.getIn(['account', 'acct'])}`} title={status.getIn(['account', 'acct'])} data-hover-card-account={status.getIn(['account', 'id'])} className='status__display-name' target='_blank' rel='noopener noreferrer'>
+              <Link to={`/@${status.getIn(['account', 'acct'])}`} title={status.getIn(['account', 'acct'])} data-hover-card-account={status.getIn(['account', 'id'])} className='status__display-name'>
                 <div className='status__avatar'>
                   {statusAvatar}
                 </div>
 
                 <DisplayName account={status.get('account')} />
-              </a>
+              </Link>
             </div>
 
             {matchedFilters && <FilterWarning title={matchedFilters.join(', ')} expanded={this.state.showDespiteFilter} onClick={this.handleFilterToggle} />}
diff --git a/app/javascript/mastodon/components/status_content.jsx b/app/javascript/mastodon/components/status_content.jsx
index 4950c896f97e7e..fe485eb3ac8cd9 100644
--- a/app/javascript/mastodon/components/status_content.jsx
+++ b/app/javascript/mastodon/components/status_content.jsx
@@ -204,8 +204,8 @@ class StatusContent extends PureComponent {
       element = element.parentNode;
     }
 
-    if (deltaX + deltaY < 5 && e.button === 0 && this.props.onClick) {
-      this.props.onClick();
+    if (deltaX + deltaY < 5 && (e.button === 0 || e.button === 1) && this.props.onClick) {
+      this.props.onClick(e);
     }
 
     this.startXY = null;
diff --git a/app/javascript/mastodon/features/notifications_v2/components/embedded_status.tsx b/app/javascript/mastodon/features/notifications_v2/components/embedded_status.tsx
index 65ea9b5d5e27bc..ca0d1bc850d446 100644
--- a/app/javascript/mastodon/features/notifications_v2/components/embedded_status.tsx
+++ b/app/javascript/mastodon/features/notifications_v2/components/embedded_status.tsx
@@ -43,7 +43,7 @@ export const EmbeddedStatus: React.FC<{ statusId: string }> = ({
   );
 
   const handleMouseUp = useCallback<React.MouseEventHandler<HTMLDivElement>>(
-    ({ clientX, clientY, target, button }) => {
+    ({ clientX, clientY, target, button, ctrlKey, metaKey }) => {
       const [startX, startY] = clickCoordinatesRef.current ?? [0, 0];
       const [deltaX, deltaY] = [
         Math.abs(clientX - startX),
@@ -64,8 +64,14 @@ export const EmbeddedStatus: React.FC<{ statusId: string }> = ({
         element = element.parentNode as HTMLDivElement | null;
       }
 
-      if (deltaX + deltaY < 5 && button === 0 && account) {
-        history.push(`/@${account.acct}/${statusId}`);
+      if (deltaX + deltaY < 5 && account) {
+        const path = `/@${account.acct}/${statusId}`;
+
+        if (button === 0 && !(ctrlKey || metaKey)) {
+          history.push(path);
+        } else if (button === 1 || (button === 0 && (ctrlKey || metaKey))) {
+          window.open(path, '_blank', 'noreferrer noopener');
+        }
       }
 
       clickCoordinatesRef.current = null;