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In fact, the simulation does not fail, but takes ages to recover - observer the console. Perhaps better handling of the reinitialization? In dymola the initialization takes about 1s, so this might be a lead.
Can you perhaps identify another troublesome parameters? These two are everywhere and thus hard to pinpoint the exact cause.
Some tunable parameters unstable in BloodyMary example.
e.g. system.T_ambient,system.p_ambient
changing them may cause simulation to go to unstable weird condition.
reproducible in https://bodylight.physiome.cz/Bodylight-Scenarios/bloodgases/#komplexnisimulator.md
Example moving pressure from 102 kPa to 91 kPa cause simulation to fail
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