diff --git a/drivers/i2c/Kconfig.nrfx b/drivers/i2c/Kconfig.nrfx
index bfde27721a8..78967177a3a 100644
--- a/drivers/i2c/Kconfig.nrfx
+++ b/drivers/i2c/Kconfig.nrfx
@@ -27,6 +27,19 @@ config I2C_NRFX_TWIM
 	select NRFX_TWIM1 if HAS_HW_NRF_TWIM1
 	select NRFX_TWIM2 if HAS_HW_NRF_TWIM2
 	select NRFX_TWIM3 if HAS_HW_NRF_TWIM3
+	select NRFX_TWIM20 if HAS_HW_NRF_TWIM20
+	select NRFX_TWIM21 if HAS_HW_NRF_TWIM21
+	select NRFX_TWIM22 if HAS_HW_NRF_TWIM22
+	select NRFX_TWIM30 if HAS_HW_NRF_TWIM30
+	select NRFX_TWIM120 if HAS_HW_NRF_TWIM120
+	select NRFX_TWIM130 if HAS_HW_NRF_TWIM130
+	select NRFX_TWIM131 if HAS_HW_NRF_TWIM131
+	select NRFX_TWIM132 if HAS_HW_NRF_TWIM132
+	select NRFX_TWIM133 if HAS_HW_NRF_TWIM133
+	select NRFX_TWIM134 if HAS_HW_NRF_TWIM134
+	select NRFX_TWIM135 if HAS_HW_NRF_TWIM135
+	select NRFX_TWIM136 if HAS_HW_NRF_TWIM136
+	select NRFX_TWIM137 if HAS_HW_NRF_TWIM137
 
 config I2C_NRFX_TRANSFER_TIMEOUT
 	int "Transfer timeout [ms]"
diff --git a/drivers/i2c/i2c_nrfx_twim.c b/drivers/i2c/i2c_nrfx_twim.c
index 13df5051ac7..55160a44c72 100644
--- a/drivers/i2c/i2c_nrfx_twim.c
+++ b/drivers/i2c/i2c_nrfx_twim.c
@@ -455,3 +455,55 @@ I2C_NRFX_TWIM_DEVICE(2);
 #ifdef CONFIG_HAS_HW_NRF_TWIM3
 I2C_NRFX_TWIM_DEVICE(3);
 #endif
+
+#ifdef CONFIG_HAS_HW_NRF_TWIM20
+I2C_NRFX_TWIM_DEVICE(20);
+#endif
+
+#ifdef CONFIG_HAS_HW_NRF_TWIM21
+I2C_NRFX_TWIM_DEVICE(21);
+#endif
+
+#ifdef CONFIG_HAS_HW_NRF_TWIM22
+I2C_NRFX_TWIM_DEVICE(22);
+#endif
+
+#ifdef CONFIG_HAS_HW_NRF_TWIM30
+I2C_NRFX_TWIM_DEVICE(30);
+#endif
+
+#ifdef CONFIG_HAS_HW_NRF_TWIM120
+I2C_NRFX_TWIM_DEVICE(120);
+#endif
+
+#ifdef CONFIG_HAS_HW_NRF_TWIM130
+I2C_NRFX_TWIM_DEVICE(130);
+#endif
+
+#ifdef CONFIG_HAS_HW_NRF_TWIM131
+I2C_NRFX_TWIM_DEVICE(131);
+#endif
+
+#ifdef CONFIG_HAS_HW_NRF_TWIM132
+I2C_NRFX_TWIM_DEVICE(132);
+#endif
+
+#ifdef CONFIG_HAS_HW_NRF_TWIM133
+I2C_NRFX_TWIM_DEVICE(133);
+#endif
+
+#ifdef CONFIG_HAS_HW_NRF_TWIM134
+I2C_NRFX_TWIM_DEVICE(134);
+#endif
+
+#ifdef CONFIG_HAS_HW_NRF_TWIM135
+I2C_NRFX_TWIM_DEVICE(135);
+#endif
+
+#ifdef CONFIG_HAS_HW_NRF_TWIM136
+I2C_NRFX_TWIM_DEVICE(136);
+#endif
+
+#ifdef CONFIG_HAS_HW_NRF_TWIM137
+I2C_NRFX_TWIM_DEVICE(137);
+#endif