diff --git a/conans/client/build/autotools_environment.py b/conans/client/build/autotools_environment.py
index 561e60bae6a..830f1588564 100644
--- a/conans/client/build/autotools_environment.py
+++ b/conans/client/build/autotools_environment.py
@@ -11,6 +11,7 @@
                                                 format_frameworks, format_framework_paths)
 from conans.client.build.cppstd_flags import cppstd_from_settings, \
     cppstd_flag_new as cppstd_flag
+from conans.client import tools
 from conans.client.tools.env import environment_append
 from conans.client.tools.oss import OSInfo, args_to_string, cpu_count, cross_building, \
     detected_architecture, detected_os, get_gnu_triplet, get_target_os_arch, get_build_os_arch
@@ -39,6 +40,7 @@ def __init__(self, conanfile, win_bash=False, include_rpath_flags=False):
         self.subsystem = OSInfo().detect_windows_subsystem() if self._win_bash else None
         self._deps_cpp_info = conanfile.deps_cpp_info
         self._os = conanfile.settings.get_safe("os")
+        self._os_version = conanfile.settings.get_safe("os.version")
         self._arch = conanfile.settings.get_safe("arch")
         self._os_target, self._arch_target = get_target_os_arch(conanfile)
 
@@ -339,6 +341,15 @@ def append(*args):
         tmp_compilation_flags = copy.copy(self.flags)
         if self.fpic:
             tmp_compilation_flags.append(pic_flag(self._conanfile.settings))
+        if tools.is_apple_os(self._os):
+            concat = " ".join(tmp_compilation_flags)
+            if os.environ.get("CFLAGS", None):
+                concat += " " + os.environ.get("CFLAGS", None)
+            if os.environ.get("CXXFLAGS", None):
+                concat += " " + os.environ.get("CXXFLAGS", None)
+            if self._os_version and "-version-min" not in concat and "-target" not in concat:
+                tmp_compilation_flags.append(tools.apple_deployment_target_flag(self._os,
+                                                                                self._os_version))
 
         cxx_flags = append(tmp_compilation_flags, self.cxx_flags, self.cppstd_flag)
         c_flags = tmp_compilation_flags
diff --git a/conans/test/unittests/client/build/autotools_environment_test.py b/conans/test/unittests/client/build/autotools_environment_test.py
index 190b6262fbb..8f947b03534 100644
--- a/conans/test/unittests/client/build/autotools_environment_test.py
+++ b/conans/test/unittests/client/build/autotools_environment_test.py
@@ -671,3 +671,30 @@ def autotools_fpic_test(self):
         self.assertFalse(ab.fpic)
         ab.fpic = True
         self.assertIn("-fPIC", ab.vars["CXXFLAGS"])
+
+    def mac_version_min_test(self):
+        options = MockOptions({})
+        settings = MockSettings({"os": "Macos"})
+        conanfile = MockConanfile(settings, options)
+        be = AutoToolsBuildEnvironment(conanfile)
+        expected = be.vars["CXXFLAGS"]
+        self.assertEqual("", expected)
+
+        settings = MockSettings({"os": "Macos",
+                                 "os.version": "10.13",
+                                 "compiler.version": "12.0"})
+        conanfile = MockConanfile(settings, options)
+        be = AutoToolsBuildEnvironment(conanfile)
+        expected = be.vars["CXXFLAGS"]
+        self.assertIn("10.13", expected)
+
+        with tools.environment_append({"CFLAGS": "-mmacosx-version-min=10.9"}):
+            be = AutoToolsBuildEnvironment(conanfile)
+            expected = be.vars["CFLAGS"]
+            self.assertIn("10.9", expected)
+            self.assertNotIn("10.13", expected)
+
+        with tools.environment_append({"CXXFLAGS": "-mmacosx-version-min=10.9"}):
+            be = AutoToolsBuildEnvironment(conanfile)
+            expected = be.vars["CFLAGS"]
+            self.assertNotIn("10.13", expected)