From e7c483e6bce489c0aa018f19c54cb2285e5b4b97 Mon Sep 17 00:00:00 2001 From: kchu25 Date: Wed, 21 Aug 2024 19:36:21 -0400 Subject: [PATCH] update --- docs/src/definitions.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/docs/src/definitions.md b/docs/src/definitions.md index b2b58f6..ee557b8 100644 --- a/docs/src/definitions.md +++ b/docs/src/definitions.md @@ -2,7 +2,7 @@ ### Definition of Information Content in Position Weight Matrices (PWM) In a position weight matrix (PWM), the "letter height", or more formally, the *information content* $IC(\cdot)$ of the $i$-th column $c_i$, quantifies how conserved the nucleotides are at that position compared to a background model. It is calculated using the formula: -$$IC(c_i) = \sum_{\alpha}f_{\alpha i}\log_2 f_{\alpha i} / \beta_\alpha$$ +$$IC(c_i) = \sum_{\alpha}f_{\alpha i}\log_2 (f_{\alpha i} / \beta_\alpha)$$ where $f_{\alpha i}$ is the frequency of nucleotide $\alpha\in\Set{A,C,G,T}$ at the $i$-th column of a PWM and $\beta_\alpha$ denotes the genomic background frequency of nucleotide $\alpha$.