From 4b42a8c0dc7bd47d8b11763a0ee48da1795430c5 Mon Sep 17 00:00:00 2001 From: sbabyanusha Date: Tue, 17 Jan 2023 18:02:32 -0500 Subject: [PATCH 1/2] Added PMID --- public/msk_met_2021/meta_study.txt | 2 +- public/msk_spectrum_tme_2022/meta_study.txt | 4 +++- 2 files changed, 4 insertions(+), 2 deletions(-) diff --git a/public/msk_met_2021/meta_study.txt b/public/msk_met_2021/meta_study.txt index f58e17087b..67f0daf169 100644 --- a/public/msk_met_2021/meta_study.txt +++ b/public/msk_met_2021/meta_study.txt @@ -2,6 +2,6 @@ type_of_cancer: mixed cancer_study_identifier: msk_met_2021 name: MSK MetTropism (MSK, Cell 2021) short_name: Mixed (MSK, Cell 2021) -description: MSK-MET (Memorial Sloan Kettering - Metastatic Events and Tropisms) is an integrated pan-cancer cohort of tumor genomic and clinical outcome data from 25,000 patients. We analyzed this dataset to identify associations between tumor genomic alterations and patterns of metastatic dissemination across 50 tumor types. We found that chromosomal instability is strongly correlated with metastatic burden in some tumor types, including prostate adenocarcinoma, lung adenocarcinoma and HR+/HER2+ breast ductal carcinoma, but not in others, such as colorectal MSS, pancreatic adenocarcinoma and high-grade serous ovarian cancer. We also identified specific somatic alterations associated with increased metastatic burden and specific routes of metastatic spread. Our data offer a unique resource for the investigation of the biologic basis for metastatic spread and highlight the crucial role of chromosomal instability in cancer progression. PubMed +description: MSK-MET (Memorial Sloan Kettering - Metastatic Events and Tropisms) is an integrated pan-cancer cohort of tumor genomic and clinical outcome data from 25,000 patients. We analyzed this dataset to identify associations between tumor genomic alterations and patterns of metastatic dissemination across 50 tumor types. We found that chromosomal instability is strongly correlated with metastatic burden in some tumor types, including prostate adenocarcinoma, lung adenocarcinoma and HR+/HER2+ breast ductal carcinoma, but not in others, such as colorectal MSS, pancreatic adenocarcinoma and high-grade serous ovarian cancer. We also identified specific somatic alterations associated with increased metastatic burden and specific routes of metastatic spread. Our data offer a unique resource for the investigation of the biologic basis for metastatic spread and highlight the crucial role of chromosomal instability in cancer progression. In this dataset the OS_MONTHS refers to the time since sequencing. PubMed pmid: 35120664 citation: Nguyen et al. Cell 2022 \ No newline at end of file diff --git a/public/msk_spectrum_tme_2022/meta_study.txt b/public/msk_spectrum_tme_2022/meta_study.txt index 54de22318d..f2355490c4 100755 --- a/public/msk_spectrum_tme_2022/meta_study.txt +++ b/public/msk_spectrum_tme_2022/meta_study.txt @@ -3,4 +3,6 @@ cancer_study_identifier: msk_spectrum_tme_2022 name: Ovarian Cancer - MSK SPECTRUM (MSK, Nature 2022) description: Multi-region, multi-modal profiling of 42 untreated high-grade serous ovarian cancer (HGSOC) patients. This study reports an integrative analysis of mutational processes and their impact on the tumor microenvironment using single-cell RNA sequencing, whole-genome sequencing, targeted sequencing (MSK-IMPACT), digital histopathology and multiplexed immunofluorescence. The study is part of a prospective research program to understand the spatio-temporal determinants of HGSOC evolution, treatment and response (MSK SPECTRUM: Memorial Sloan Kettering - SPatio-temporal Evolution in Cancer TRaced Using Multi-modalities). groups: PUBLIC -short_name: SPECTRUM (MSK, 2022) \ No newline at end of file +short_name: SPECTRUM (MSK, 2022) +pmid: 36517593 +citation: Ignacio et al. Nature 2022 \ No newline at end of file From be45a7245d75848456e461320e316faeed9aa7ab Mon Sep 17 00:00:00 2001 From: sbabyanusha Date: Wed, 18 Jan 2023 15:15:43 -0500 Subject: [PATCH 2/2] update os months description --- public/msk_met_2021/data_clinical_patient.txt | 4 ++-- public/msk_met_2021/meta_study.txt | 2 +- 2 files changed, 3 insertions(+), 3 deletions(-) diff --git a/public/msk_met_2021/data_clinical_patient.txt b/public/msk_met_2021/data_clinical_patient.txt index 97a2f88799..537d2e2165 100644 --- a/public/msk_met_2021/data_clinical_patient.txt +++ b/public/msk_met_2021/data_clinical_patient.txt @@ -1,3 +1,3 @@ version https://git-lfs.github.com/spec/v1 -oid sha256:6adc59b2c965fd6b163296625018650ff01369a9480a330d5641d40bfafdb623 -size 1650828 +oid sha256:61e7835e4fcf5b2821baa9ada4543dea74785c376042291c5b444cd3944ca09a +size 1650827 diff --git a/public/msk_met_2021/meta_study.txt b/public/msk_met_2021/meta_study.txt index 67f0daf169..f58e17087b 100644 --- a/public/msk_met_2021/meta_study.txt +++ b/public/msk_met_2021/meta_study.txt @@ -2,6 +2,6 @@ type_of_cancer: mixed cancer_study_identifier: msk_met_2021 name: MSK MetTropism (MSK, Cell 2021) short_name: Mixed (MSK, Cell 2021) -description: MSK-MET (Memorial Sloan Kettering - Metastatic Events and Tropisms) is an integrated pan-cancer cohort of tumor genomic and clinical outcome data from 25,000 patients. We analyzed this dataset to identify associations between tumor genomic alterations and patterns of metastatic dissemination across 50 tumor types. We found that chromosomal instability is strongly correlated with metastatic burden in some tumor types, including prostate adenocarcinoma, lung adenocarcinoma and HR+/HER2+ breast ductal carcinoma, but not in others, such as colorectal MSS, pancreatic adenocarcinoma and high-grade serous ovarian cancer. We also identified specific somatic alterations associated with increased metastatic burden and specific routes of metastatic spread. Our data offer a unique resource for the investigation of the biologic basis for metastatic spread and highlight the crucial role of chromosomal instability in cancer progression. In this dataset the OS_MONTHS refers to the time since sequencing. PubMed +description: MSK-MET (Memorial Sloan Kettering - Metastatic Events and Tropisms) is an integrated pan-cancer cohort of tumor genomic and clinical outcome data from 25,000 patients. We analyzed this dataset to identify associations between tumor genomic alterations and patterns of metastatic dissemination across 50 tumor types. We found that chromosomal instability is strongly correlated with metastatic burden in some tumor types, including prostate adenocarcinoma, lung adenocarcinoma and HR+/HER2+ breast ductal carcinoma, but not in others, such as colorectal MSS, pancreatic adenocarcinoma and high-grade serous ovarian cancer. We also identified specific somatic alterations associated with increased metastatic burden and specific routes of metastatic spread. Our data offer a unique resource for the investigation of the biologic basis for metastatic spread and highlight the crucial role of chromosomal instability in cancer progression. PubMed pmid: 35120664 citation: Nguyen et al. Cell 2022 \ No newline at end of file