diff --git a/truss-chains/tests/test_e2e.py b/truss-chains/tests/test_e2e.py
index 122fe1b05..86da35eff 100644
--- a/truss-chains/tests/test_e2e.py
+++ b/truss-chains/tests/test_e2e.py
@@ -224,3 +224,49 @@ def test_numpy_chain(mode):
             response = service.run_remote({})
             assert response.status_code == 200
             print(response.json())
+
+
+@pytest.mark.asyncio
+async def test_timeout():
+    with ensure_kill_all():
+        chain_root = TEST_ROOT / "timeout" / "timeout_chain.py"
+        with framework.import_target(chain_root, "TimeoutChain") as entrypoint:
+            options = definitions.PushOptionsLocalDocker(
+                chain_name="integration-test", use_local_chains_src=True
+            )
+            service = deployment_client.push(entrypoint, options)
+
+        url = service.run_remote_url.replace("host.docker.internal", "localhost")
+        time.sleep(1.0)  # Wait for models to be ready.
+
+        # Async.
+        response = requests.post(url, json={"use_sync": False})
+        # print(response.content)
+
+        assert response.status_code == 500
+        error = definitions.RemoteErrorDetail.model_validate(response.json()["error"])
+        error_str = error.format()
+        error_regex = r"""
+Chainlet-Traceback \(most recent call last\):
+  File \".*?/timeout_chain\.py\", line \d+, in run_remote
+    result = await self\._dep.run_remote\(\)
+TimeoutError: Timeout calling remote Chainlet `Dependency` \(0.5 seconds limit\)\.
+        """
+        assert re.match(error_regex.strip(), error_str.strip(), re.MULTILINE), error_str
+
+        # Sync:
+        sync_response = requests.post(url, json={"use_sync": True})
+        assert sync_response.status_code == 500
+        sync_error = definitions.RemoteErrorDetail.model_validate(
+            sync_response.json()["error"]
+        )
+        sync_error_str = sync_error.format()
+        sync_error_regex = r"""
+Chainlet-Traceback \(most recent call last\):
+  File \".*?/timeout_chain\.py\", line \d+, in run_remote
+    result = self\._dep_sync.run_remote\(\)
+TimeoutError: Timeout calling remote Chainlet `DependencySync` \(0.5 seconds limit\)\.
+        """
+        assert re.match(
+            sync_error_regex.strip(), sync_error_str.strip(), re.MULTILINE
+        ), sync_error_str
diff --git a/truss-chains/tests/timeout/timeout_chain.py b/truss-chains/tests/timeout/timeout_chain.py
new file mode 100644
index 000000000..5a4a61519
--- /dev/null
+++ b/truss-chains/tests/timeout/timeout_chain.py
@@ -0,0 +1,35 @@
+import asyncio
+import time
+
+import truss_chains as chains
+
+
+class Dependency(chains.ChainletBase):
+    async def run_remote(self) -> bool:
+        await asyncio.sleep(1)
+        return True
+
+
+class DependencySync(chains.ChainletBase):
+    def run_remote(self) -> bool:
+        time.sleep(1)
+        return True
+
+
+@chains.mark_entrypoint  # ("My Chain Name")
+class TimeoutChain(chains.ChainletBase):
+    def __init__(
+        self,
+        dep=chains.depends(Dependency, timeout_sec=0.5),
+        dep_sync=chains.depends(DependencySync, timeout_sec=0.5),
+    ):
+        self._dep = dep
+        self._dep_sync = dep_sync
+
+    async def run_remote(self, use_sync: bool) -> None:
+        if use_sync:
+            result = self._dep_sync.run_remote()
+            print(result)
+        else:
+            result = await self._dep.run_remote()
+            print(result)
diff --git a/truss-chains/truss_chains/definitions.py b/truss-chains/truss_chains/definitions.py
index 3bb6a27e3..8e6a9ae97 100644
--- a/truss-chains/truss_chains/definitions.py
+++ b/truss-chains/truss_chains/definitions.py
@@ -396,7 +396,7 @@ def get_asset_spec(self) -> AssetSpec:
         return self.assets.get_spec()
 
 
-DEFAULT_TIMEOUT_SEC = 600
+DEFAULT_TIMEOUT_SEC = 600.0
 
 
 class RPCOptions(SafeModel):
@@ -415,7 +415,7 @@ class RPCOptions(SafeModel):
     """
 
     retries: int = 1
-    timeout_sec: int = DEFAULT_TIMEOUT_SEC
+    timeout_sec: float = DEFAULT_TIMEOUT_SEC
     use_binary: bool = False
 
 
diff --git a/truss-chains/truss_chains/public_api.py b/truss-chains/truss_chains/public_api.py
index 90e27f58e..ecb1be35a 100644
--- a/truss-chains/truss_chains/public_api.py
+++ b/truss-chains/truss_chains/public_api.py
@@ -46,7 +46,7 @@ def depends_context() -> definitions.DeploymentContext:
 def depends(
     chainlet_cls: Type[framework.ChainletT],
     retries: int = 1,
-    timeout_sec: int = definitions.DEFAULT_TIMEOUT_SEC,
+    timeout_sec: float = definitions.DEFAULT_TIMEOUT_SEC,
     use_binary: bool = False,
 ) -> framework.ChainletT:
     """Sets a "symbolic marker" to indicate to the framework that a chainlet is a
diff --git a/truss-chains/truss_chains/remote_chainlet/stub.py b/truss-chains/truss_chains/remote_chainlet/stub.py
index 95a3c43d8..f556b6c36 100644
--- a/truss-chains/truss_chains/remote_chainlet/stub.py
+++ b/truss-chains/truss_chains/remote_chainlet/stub.py
@@ -329,7 +329,16 @@ def _rpc() -> bytes:
             utils.response_raise_errors(response, self.name)
             return response.content
 
-        response_bytes = retry(_rpc)
+        try:
+            response_bytes = retry(_rpc)
+        except httpx.ReadTimeout:
+            msg = (
+                f"Timeout calling remote Chainlet `{self.name}` "
+                f"({self._service_descriptor.options.timeout_sec} seconds limit)."
+            )
+            logging.warning(msg)
+            raise TimeoutError(msg) from None  # Prune error stack trace (TMI).
+
         if output_model:
             return self._response_to_pydantic(response_bytes, output_model)
         return self._response_to_json(response_bytes)
@@ -357,7 +366,16 @@ async def _rpc() -> bytes:
                     await utils.async_response_raise_errors(response, self.name)
                     return await response.read()
 
-        response_bytes: bytes = await retry(_rpc)
+        try:
+            response_bytes: bytes = await retry(_rpc)
+        except asyncio.TimeoutError:
+            msg = (
+                f"Timeout calling remote Chainlet `{self.name}` "
+                f"({self._service_descriptor.options.timeout_sec} seconds limit)."
+            )
+            logging.warning(msg)
+            raise TimeoutError(msg) from None  # Prune error stack trace (TMI).
+
         if output_model:
             return self._response_to_pydantic(response_bytes, output_model)
         return self._response_to_json(response_bytes)
@@ -375,7 +393,15 @@ async def _rpc() -> AsyncIterator[bytes]:
                 await utils.async_response_raise_errors(response, self.name)
                 return response.content.iter_any()
 
-        return await retry(_rpc)
+        try:
+            return await retry(_rpc)
+        except asyncio.TimeoutError:
+            msg = (
+                f"Timeout calling remote Chainlet `{self.name}` "
+                f"({self._service_descriptor.options.timeout_sec} seconds limit)."
+            )
+            logging.warning(msg)
+            raise TimeoutError(msg) from None  # Prune error stack trace (TMI).
 
 
 StubT = TypeVar("StubT", bound=StubBase)