diff --git a/.github/install_osx_dependencies.sh b/.github/install_osx_dependencies.sh
index d154e7f87b2..8447c871a2f 100755
--- a/.github/install_osx_dependencies.sh
+++ b/.github/install_osx_dependencies.sh
@@ -26,4 +26,4 @@ brew_install_if_not_installed coreutils
 brew_install_if_not_installed cppcheck
 brew_install_if_not_installed pkg-config  # for gnutls compilation
 brew_install_if_not_installed ninja
-brew_install_if_not_installed openssl@1.1 # for libcrypto
+brew_install_if_not_installed openssl@3 # for libcrypto
diff --git a/.github/s2n_osx.sh b/.github/s2n_osx.sh
index d166fba9224..82c0db8de44 100755
--- a/.github/s2n_osx.sh
+++ b/.github/s2n_osx.sh
@@ -14,17 +14,17 @@
 # permissions and limitations under the License.
 #
 set -eu
-source codebuild/bin/s2n_setup_env.sh
 
+export S2N_LIBCRYPTO=openssl-3.4
 export CTEST_OUTPUT_ON_FAILURE=1
-BREWINSTLLPATH=$(brew --prefix openssl@1.1)
-OPENSSL_1_1_1_INSTALL_DIR="${BREWINSTLLPATH:-"/usr/local/Cellar/openssl@1.1/1.1.1?"}"
+BREWINSTLLPATH=$(brew --prefix openssl@3)
+OPENSSL_3_INSTALL_DIR="${BREWINSTLLPATH:-"/opt/homebrew/Cellar/openssl@3"}"
 
-echo "Using OpenSSL at $OPENSSL_1_1_1_INSTALL_DIR"
+echo "Using OpenSSL at $OPENSSL_3_INSTALL_DIR"
 # Build with debug symbols and a specific OpenSSL version
 cmake . -Bbuild -GNinja \
 -DCMAKE_BUILD_TYPE=Debug \
--DCMAKE_PREFIX_PATH=${OPENSSL_1_1_1_INSTALL_DIR} ..
+-DCMAKE_PREFIX_PATH=${OPENSSL_3_INSTALL_DIR} ..
 
 cmake --build ./build -j $(nproc)
 time CTEST_PARALLEL_LEVEL=$(nproc) ninja -C build test
@@ -32,7 +32,7 @@ time CTEST_PARALLEL_LEVEL=$(nproc) ninja -C build test
 # Build shared library
 cmake . -Bbuild -GNinja \
 -DCMAKE_BUILD_TYPE=Debug \
--DCMAKE_PREFIX_PATH=${OPENSSL_1_1_1_INSTALL_DIR} .. \
+-DCMAKE_PREFIX_PATH=${OPENSSL_3_INSTALL_DIR} .. \
 -DBUILD_SHARED_LIBS=ON
 
 cmake --build ./build -j $(nproc)
diff --git a/tests/unit/s2n_build_test.c b/tests/unit/s2n_build_test.c
index c89bca54b3b..ad456982cbe 100644
--- a/tests/unit/s2n_build_test.c
+++ b/tests/unit/s2n_build_test.c
@@ -82,6 +82,7 @@ S2N_RESULT s2n_check_supported_libcrypto(const char *s2n_libcrypto)
         { .libcrypto = "openssl-1.0.2", .is_openssl = true },
         { .libcrypto = "openssl-1.1.1", .is_openssl = true },
         { .libcrypto = "openssl-3.0", .is_openssl = true },
+        { .libcrypto = "openssl-3.4", .is_openssl = true },
     };
 
     for (size_t i = 0; i < s2n_array_len(supported_libcrypto); i++) {