diff --git a/crates/uv/src/commands/pip_compile.rs b/crates/uv/src/commands/pip_compile.rs
index 8afd94c855d2..808b4f0d2a3c 100644
--- a/crates/uv/src/commands/pip_compile.rs
+++ b/crates/uv/src/commands/pip_compile.rs
@@ -56,6 +56,7 @@ pub(crate) async fn pip_compile(
     no_emit_packages: Vec<PackageName>,
     include_annotations: bool,
     include_header: bool,
+    custom_compile_command: Option<String>,
     include_index_url: bool,
     include_find_links: bool,
     index_locations: IndexLocations,
@@ -369,7 +370,15 @@ pub(crate) async fn pip_compile(
         writeln!(
             writer,
             "{}",
-            format!("#    {}", cmd(include_index_url, include_find_links,)).green()
+            format!(
+                "#    {}",
+                cmd(
+                    include_index_url,
+                    include_find_links,
+                    custom_compile_command
+                )
+            )
+            .green()
         )?;
     }
 
@@ -435,7 +444,14 @@ pub(crate) async fn pip_compile(
 
 /// Format the `uv` command used to generate the output file.
 #[allow(clippy::fn_params_excessive_bools)]
-fn cmd(include_index_url: bool, include_find_links: bool) -> String {
+fn cmd(
+    include_index_url: bool,
+    include_find_links: bool,
+    custom_compile_command: Option<String>,
+) -> String {
+    if let Some(cmd_str) = custom_compile_command {
+        return cmd_str;
+    }
     let args = env::args_os()
         .skip(1)
         .map(|arg| arg.simplified_display().to_string())
diff --git a/crates/uv/src/main.rs b/crates/uv/src/main.rs
index ee99de892001..2404e11733d1 100644
--- a/crates/uv/src/main.rs
+++ b/crates/uv/src/main.rs
@@ -324,6 +324,10 @@ struct PipCompileArgs {
     #[clap(long)]
     no_header: bool,
 
+    /// Change header comment to reflect custom command wrapping `uv pip compile`.
+    #[clap(long, env = "UV_CUSTOM_COMPILE_COMMAND")]
+    custom_compile_command: Option<String>,
+
     /// Run offline, i.e., without accessing the network.
     #[arg(
         global = true,
@@ -1507,6 +1511,7 @@ async fn run() -> Result<ExitStatus> {
                 args.no_emit_package,
                 !args.no_annotate,
                 !args.no_header,
+                args.custom_compile_command,
                 args.emit_index_url,
                 args.emit_find_links,
                 index_urls,
diff --git a/crates/uv/tests/pip_compile.rs b/crates/uv/tests/pip_compile.rs
index 9430c6f1fec2..9efdbde77a82 100644
--- a/crates/uv/tests/pip_compile.rs
+++ b/crates/uv/tests/pip_compile.rs
@@ -3482,6 +3482,68 @@ fn no_header() -> Result<()> {
     Ok(())
 }
 
+/// Include custom compile command in the header.
+#[test]
+fn custom_compile_command() -> Result<()> {
+    let context = TestContext::new("3.12");
+    let requirements_in = context.temp_dir.child("requirements.in");
+    requirements_in.write_str("black==23.10.1")?;
+
+    uv_snapshot!(context.compile()
+            .arg("requirements.in")
+            .arg("--custom-compile-command")
+            .arg("./custom-uv-compile.sh"), @r###"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+    # This file was autogenerated by uv via the following command:
+    #    ./custom-uv-compile.sh
+    black==23.10.1
+    click==8.1.7
+        # via black
+    mypy-extensions==1.0.0
+        # via black
+    packaging==23.2
+        # via black
+    pathspec==0.11.2
+        # via black
+    platformdirs==4.0.0
+        # via black
+
+    ----- stderr -----
+    Resolved 6 packages in [TIME]
+    "###
+    );
+
+    // with env var
+    uv_snapshot!(context.compile()
+            .arg("requirements.in")
+            .env("UV_CUSTOM_COMPILE_COMMAND", "./custom-uv-compile.sh"), @r###"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+    # This file was autogenerated by uv via the following command:
+    #    ./custom-uv-compile.sh
+    black==23.10.1
+    click==8.1.7
+        # via black
+    mypy-extensions==1.0.0
+        # via black
+    packaging==23.2
+        # via black
+    pathspec==0.11.2
+        # via black
+    platformdirs==4.0.0
+        # via black
+
+    ----- stderr -----
+    Resolved 6 packages in [TIME]
+    "###
+    );
+
+    Ok(())
+}
+
 /// Emit warnings when users pass redundant options from `pip-compile`.
 #[test]
 fn allow_unsafe() -> Result<()> {