diff --git a/crates/ruff_linter/resources/test/fixtures/flake8_type_checking/quote.py b/crates/ruff_linter/resources/test/fixtures/flake8_type_checking/quote.py
index 547cd30117672..d344b0cfac781 100644
--- a/crates/ruff_linter/resources/test/fixtures/flake8_type_checking/quote.py
+++ b/crates/ruff_linter/resources/test/fixtures/flake8_type_checking/quote.py
@@ -90,3 +90,14 @@ def f():
 
     def func(self) -> DataFrame | list[Series]:
         pass
+
+
+def f():
+    from typing import Annotated
+
+    from fastapi import Depends
+
+    from .foo import get_foo
+
+    def test_annotated_non_typing_reference(user: Annotated[str, Depends(get_foo)]):
+        pass
diff --git a/crates/ruff_linter/resources/test/fixtures/flake8_type_checking/quote2.py b/crates/ruff_linter/resources/test/fixtures/flake8_type_checking/quote2.py
index 4433416da5087..7e2b9fd0c6de4 100644
--- a/crates/ruff_linter/resources/test/fixtures/flake8_type_checking/quote2.py
+++ b/crates/ruff_linter/resources/test/fixtures/flake8_type_checking/quote2.py
@@ -85,3 +85,14 @@ def f():
 
     def test_optional_literal_no_removal(arg: Optional[Literal["red", "blue"]]):
         pass
+
+
+def f():
+    from typing import Annotated
+
+    from fastapi import Depends
+
+    from .foo import get_foo
+
+    def test_annotated_non_typing_reference(user: Annotated[str, Depends(get_foo)]):
+        pass
diff --git a/crates/ruff_linter/resources/test/fixtures/flake8_type_checking/quote3.py b/crates/ruff_linter/resources/test/fixtures/flake8_type_checking/quote3.py
index b360230b4e6e1..f2c624886056e 100644
--- a/crates/ruff_linter/resources/test/fixtures/flake8_type_checking/quote3.py
+++ b/crates/ruff_linter/resources/test/fixtures/flake8_type_checking/quote3.py
@@ -42,3 +42,14 @@ def f():
     def test_attribute_typing_literal(arg: models.AbstractBaseUser[Literal["admin"]]):
         pass
 
+
+def f():
+    from typing import Annotated
+
+    from fastapi import Depends
+
+    from .foo import get_foo
+
+    def test_annotated_non_typing_reference(user: Annotated[str, Depends(get_foo)]):
+        pass
+
diff --git a/crates/ruff_linter/src/rules/flake8_type_checking/helpers.rs b/crates/ruff_linter/src/rules/flake8_type_checking/helpers.rs
index cd86affbeff30..04d627a8e9dff 100644
--- a/crates/ruff_linter/src/rules/flake8_type_checking/helpers.rs
+++ b/crates/ruff_linter/src/rules/flake8_type_checking/helpers.rs
@@ -19,10 +19,13 @@ use crate::rules::flake8_type_checking::settings::Settings;
 /// context (with quoting enabled).
 pub(crate) fn is_typing_reference(reference: &ResolvedReference, settings: &Settings) -> bool {
     reference.in_type_checking_block()
-        || reference.in_typing_only_annotation()
-        || reference.in_complex_string_type_definition()
-        || reference.in_simple_string_type_definition()
-        || (settings.quote_annotations && reference.in_runtime_evaluated_annotation())
+        // if we're not in a type checking block, we necessarily need to be within a
+        // type definition to be considered a typing reference
+        || (reference.in_type_definition()
+            && (reference.in_typing_only_annotation()
+                || reference.in_complex_string_type_definition()
+                || reference.in_simple_string_type_definition()
+                || (settings.quote_annotations && reference.in_runtime_evaluated_annotation())))
 }
 
 /// Returns `true` if the [`Binding`] represents a runtime-required import.
diff --git a/crates/ruff_linter/src/rules/flake8_type_checking/snapshots/ruff_linter__rules__flake8_type_checking__tests__quote_typing-only-third-party-import_quote.py.snap b/crates/ruff_linter/src/rules/flake8_type_checking/snapshots/ruff_linter__rules__flake8_type_checking__tests__quote_typing-only-third-party-import_quote.py.snap
index cc72734ecf5e9..ff6f2e6437542 100644
--- a/crates/ruff_linter/src/rules/flake8_type_checking/snapshots/ruff_linter__rules__flake8_type_checking__tests__quote_typing-only-third-party-import_quote.py.snap
+++ b/crates/ruff_linter/src/rules/flake8_type_checking/snapshots/ruff_linter__rules__flake8_type_checking__tests__quote_typing-only-third-party-import_quote.py.snap
@@ -379,6 +379,8 @@ quote.py:89:24: TCH002 [*] Move third-party import `pandas.DataFrame` into a typ
 91    |-    def func(self) -> DataFrame | list[Series]:
    94 |+    def func(self) -> "DataFrame | list[Series]":
 92 95 |         pass
+93 96 | 
+94 97 | 
 
 quote.py:89:35: TCH002 [*] Move third-party import `pandas.Series` into a type-checking block
    |
@@ -407,3 +409,5 @@ quote.py:89:35: TCH002 [*] Move third-party import `pandas.Series` into a type-c
 91    |-    def func(self) -> DataFrame | list[Series]:
    94 |+    def func(self) -> "DataFrame | list[Series]":
 92 95 |         pass
+93 96 | 
+94 97 |
diff --git a/crates/ruff_linter/src/rules/flake8_type_checking/snapshots/ruff_linter__rules__flake8_type_checking__tests__quote_typing-only-third-party-import_quote3.py.snap b/crates/ruff_linter/src/rules/flake8_type_checking/snapshots/ruff_linter__rules__flake8_type_checking__tests__quote_typing-only-third-party-import_quote3.py.snap
index 579cc74973b14..01853a363783d 100644
--- a/crates/ruff_linter/src/rules/flake8_type_checking/snapshots/ruff_linter__rules__flake8_type_checking__tests__quote_typing-only-third-party-import_quote3.py.snap
+++ b/crates/ruff_linter/src/rules/flake8_type_checking/snapshots/ruff_linter__rules__flake8_type_checking__tests__quote_typing-only-third-party-import_quote3.py.snap
@@ -149,4 +149,5 @@ quote3.py:40:37: TCH002 [*] Move third-party import `django.contrib.auth.models`
 42    |-    def test_attribute_typing_literal(arg: models.AbstractBaseUser[Literal["admin"]]):
    45 |+    def test_attribute_typing_literal(arg: 'models.AbstractBaseUser[Literal["admin"]]'):
 43 46 |         pass
-44 47 |
+44 47 | 
+45 48 |
diff --git a/crates/ruff_python_semantic/src/reference.rs b/crates/ruff_python_semantic/src/reference.rs
index 1b9b7364b0b27..de6fab30216f0 100644
--- a/crates/ruff_python_semantic/src/reference.rs
+++ b/crates/ruff_python_semantic/src/reference.rs
@@ -87,6 +87,11 @@ impl ResolvedReference {
             .intersects(SemanticModelFlags::DEFERRED_TYPE_DEFINITION)
     }
 
+    /// Return `true` if the context is in any kind of type definition.
+    pub const fn in_type_definition(&self) -> bool {
+        self.flags.intersects(SemanticModelFlags::TYPE_DEFINITION)
+    }
+
     /// Return `true` if the context is in a type-checking block.
     pub const fn in_type_checking_block(&self) -> bool {
         self.flags