diff --git a/pyupgrade/_plugins/open_mode.py b/pyupgrade/_plugins/open_mode.py
index 271007a1..a8cad514 100644
--- a/pyupgrade/_plugins/open_mode.py
+++ b/pyupgrade/_plugins/open_mode.py
@@ -1,6 +1,8 @@
 import ast
+import functools
 from typing import Iterable
 from typing import List
+from typing import NamedTuple
 from typing import Tuple
 
 from tokenize_rt import Offset
@@ -21,19 +23,28 @@
 U_MODE_REPLACE = U_MODE_REPLACE_R | U_MODE_REMOVE_U
 
 
-def _fix_open_mode(i: int, tokens: List[Token]) -> None:
+class FunctionArg(NamedTuple):
+    arg_idx: int
+    value: ast.expr
+
+
+def _fix_open_mode(i: int, tokens: List[Token], *, arg_idx: int) -> None:
     j = find_open_paren(tokens, i)
     func_args, end = parse_call_args(tokens, j)
-    mode = tokens_to_src(tokens[slice(*func_args[1])])
-    mode_stripped = mode.strip().strip('"\'')
+    mode = tokens_to_src(tokens[slice(*func_args[arg_idx])])
+    mode_stripped = mode.split('=')[-1]
+    mode_stripped = mode_stripped.strip().strip('"\'')
     if mode_stripped in U_MODE_REMOVE:
-        del tokens[func_args[0][1]:func_args[1][1]]
+        if arg_idx == 0:
+            del tokens[func_args[arg_idx][0]: func_args[arg_idx + 1][0]]
+        else:
+            del tokens[func_args[arg_idx - 1][1]:func_args[arg_idx][1]]
     elif mode_stripped in U_MODE_REPLACE_R:
         new_mode = mode.replace('U', 'r')
-        tokens[slice(*func_args[1])] = [Token('SRC', new_mode)]
+        tokens[slice(*func_args[arg_idx])] = [Token('SRC', new_mode)]
     elif mode_stripped in U_MODE_REMOVE_U:
         new_mode = mode.replace('U', '')
-        tokens[slice(*func_args[1])] = [Token('SRC', new_mode)]
+        tokens[slice(*func_args[arg_idx])] = [Token('SRC', new_mode)]
     else:
         raise AssertionError(f'unreachable: {mode!r}')
 
@@ -48,11 +59,37 @@ def visit_Call(
             state.settings.min_version >= (3,) and
             isinstance(node.func, ast.Name) and
             node.func.id == 'open' and
-            not has_starargs(node) and
-            len(node.args) >= 2 and
-            isinstance(node.args[1], ast.Str) and (
+            not has_starargs(node)
+    ):
+        if len(node.args) >= 2 and isinstance(node.args[1], ast.Str):
+            if (
                 node.args[1].s in U_MODE_REPLACE or
                 (len(node.args) == 2 and node.args[1].s in U_MODE_REMOVE)
+            ):
+                func = functools.partial(
+                    _fix_open_mode,
+                    arg_idx=1,
+                )
+                yield ast_to_offset(node), func
+        elif node.keywords and (len(node.keywords) + len(node.args) > 1):
+            mode = next(
+                (
+                    FunctionArg(n, keyword.value)
+                    for n, keyword in enumerate(node.keywords)
+                    if keyword.arg == 'mode'
+                ),
+                None,
             )
-    ):
-        yield ast_to_offset(node), _fix_open_mode
+            if (
+                mode is not None and
+                isinstance(mode.value, ast.Str) and
+                (
+                    mode.value.s in U_MODE_REMOVE or
+                    mode.value.s in U_MODE_REPLACE
+                )
+            ):
+                func = functools.partial(
+                    _fix_open_mode,
+                    arg_idx=len(node.args) + mode.arg_idx,
+                )
+                yield ast_to_offset(node), func
diff --git a/tests/features/open_mode_test.py b/tests/features/open_mode_test.py
index 92826ad3..bffc854b 100644
--- a/tests/features/open_mode_test.py
+++ b/tests/features/open_mode_test.py
@@ -9,9 +9,13 @@
     (
         # already a reduced mode
         'open("foo", "w")',
+        'open("foo", mode="w")',
         'open("foo", "rb")',
         # nonsense mode
         'open("foo", "Uw")',
+        'open("foo", qux="r")',
+        'open("foo", 3)',
+        'open(mode="r")',
         # TODO: could maybe be rewritten to remove t?
         'open("foo", "wt")',
         # don't remove this, they meant to use `encoding=`
@@ -26,12 +30,38 @@ def test_fix_open_mode_noop(s):
     ('s', 'expected'),
     (
         ('open("foo", "U")', 'open("foo")'),
+        ('open("foo", mode="U")', 'open("foo")'),
         ('open("foo", "Ur")', 'open("foo")'),
+        ('open("foo", mode="Ur")', 'open("foo")'),
         ('open("foo", "Ub")', 'open("foo", "rb")'),
+        ('open("foo", mode="Ub")', 'open("foo", mode="rb")'),
         ('open("foo", "rUb")', 'open("foo", "rb")'),
+        ('open("foo", mode="rUb")', 'open("foo", mode="rb")'),
         ('open("foo", "r")', 'open("foo")'),
+        ('open("foo", mode="r")', 'open("foo")'),
         ('open("foo", "rt")', 'open("foo")'),
+        ('open("foo", mode="rt")', 'open("foo")'),
         ('open("f", "r", encoding="UTF-8")', 'open("f", encoding="UTF-8")'),
+        (
+            'open("f", mode="r", encoding="UTF-8")',
+            'open("f", encoding="UTF-8")',
+        ),
+        (
+            'open(file="f", mode="r", encoding="UTF-8")',
+            'open(file="f", encoding="UTF-8")',
+        ),
+        (
+            'open("f", encoding="UTF-8", mode="r")',
+            'open("f", encoding="UTF-8")',
+        ),
+        (
+            'open(file="f", encoding="UTF-8", mode="r")',
+            'open(file="f", encoding="UTF-8")',
+        ),
+        (
+            'open(mode="r", encoding="UTF-8", file="t.py")',
+            'open( encoding="UTF-8", file="t.py")',
+        ),
     ),
 )
 def test_fix_open_mode(s, expected):