diff --git a/goldens/public-api/core/rxjs-interop/index.api.md b/goldens/public-api/core/rxjs-interop/index.api.md
index ac9d9021a34b69..b487f39a244c6c 100644
--- a/goldens/public-api/core/rxjs-interop/index.api.md
+++ b/goldens/public-api/core/rxjs-interop/index.api.md
@@ -10,6 +10,9 @@ import { MonoTypeOperatorFunction } from 'rxjs';
 import { Observable } from 'rxjs';
 import { OutputOptions } from '@angular/core';
 import { OutputRef } from '@angular/core';
+import { ResourceLoaderParams } from '@angular/core';
+import { ResourceOptions } from '@angular/core';
+import { ResourceRef } from '@angular/core';
 import { Signal } from '@angular/core';
 import { Subscribable } from 'rxjs';
 import { ValueEqualityFn } from '@angular/core/primitives/signals';
@@ -20,6 +23,15 @@ export function outputFromObservable<T>(observable: Observable<T>, opts?: Output
 // @public
 export function outputToObservable<T>(ref: OutputRef<T>): Observable<T>;
 
+// @public
+export function rxResource<T, R>(opts: RxResourceOptions<T, R>): ResourceRef<T>;
+
+// @public
+export interface RxResourceOptions<T, R> extends Omit<ResourceOptions<T, R>, 'loader'> {
+    // (undocumented)
+    loader: (params: ResourceLoaderParams<R>) => Observable<T>;
+}
+
 // @public
 export function takeUntilDestroyed<T>(destroyRef?: DestroyRef): MonoTypeOperatorFunction<T>;
 
diff --git a/packages/core/rxjs-interop/src/index.ts b/packages/core/rxjs-interop/src/index.ts
index e2b0b1b57fb639..364ac8233eef79 100644
--- a/packages/core/rxjs-interop/src/index.ts
+++ b/packages/core/rxjs-interop/src/index.ts
@@ -15,3 +15,4 @@ export {
   toObservableMicrotask as ɵtoObservableMicrotask,
 } from './to_observable';
 export {toSignal, ToSignalOptions} from './to_signal';
+export {RxResourceOptions, rxResource} from './rx_resource';
diff --git a/packages/core/rxjs-interop/src/rx_resource.ts b/packages/core/rxjs-interop/src/rx_resource.ts
new file mode 100644
index 00000000000000..3e307d34ef9b7c
--- /dev/null
+++ b/packages/core/rxjs-interop/src/rx_resource.ts
@@ -0,0 +1,44 @@
+/**
+ * @license
+ * Copyright Google LLC All Rights Reserved.
+ *
+ * Use of this source code is governed by an MIT-style license that can be
+ * found in the LICENSE file at https://angular.dev/license
+ */
+
+import {
+  assertInInjectionContext,
+  ResourceOptions,
+  resource,
+  ResourceLoaderParams,
+  ResourceRef,
+} from '@angular/core';
+import {firstValueFrom, Observable, Subject} from 'rxjs';
+import {takeUntil} from 'rxjs/operators';
+
+/**
+ * Like `ResourceOptions` but uses an RxJS-based `loader`.
+ *
+ * @experimental
+ */
+export interface RxResourceOptions<T, R> extends Omit<ResourceOptions<T, R>, 'loader'> {
+  loader: (params: ResourceLoaderParams<R>) => Observable<T>;
+}
+
+/**
+ * Like `resource` but uses an RxJS based `loader` which maps the request to an `Observable` of the
+ * resource's value. Like `firstValueFrom`, only the first emission of the Observable is considered.
+ *
+ * @experimental
+ */
+export function rxResource<T, R>(opts: RxResourceOptions<T, R>): ResourceRef<T> {
+  opts?.injector || assertInInjectionContext(rxResource);
+  return resource<T, R>({
+    ...opts,
+    loader: (params) => {
+      const cancelled = new Subject<void>();
+      params.abortSignal.addEventListener('abort', () => cancelled.next());
+      return firstValueFrom(opts.loader(params).pipe(takeUntil(cancelled)));
+    },
+  });
+}
diff --git a/packages/core/rxjs-interop/test/rx_resource_spec.ts b/packages/core/rxjs-interop/test/rx_resource_spec.ts
new file mode 100644
index 00000000000000..5673c67203b471
--- /dev/null
+++ b/packages/core/rxjs-interop/test/rx_resource_spec.ts
@@ -0,0 +1,61 @@
+/**
+ * @license
+ * Copyright Google LLC All Rights Reserved.
+ *
+ * Use of this source code is governed by an MIT-style license that can be
+ * found in the LICENSE file at https://angular.dev/license
+ */
+
+import {of, Observable} from 'rxjs';
+import {TestBed} from '@angular/core/testing';
+import {ApplicationRef, Injector, signal} from '@angular/core';
+import {rxResource} from '@angular/core/rxjs-interop';
+
+describe('rxResource()', () => {
+  it('should fetch data using an observable loader', async () => {
+    const injector = TestBed.inject(Injector);
+    const appRef = TestBed.inject(ApplicationRef);
+    const res = rxResource({
+      loader: () => of(1),
+      injector,
+    });
+    await appRef.whenStable();
+    expect(res.value()).toBe(1);
+  });
+
+  it('should cancel the fetch when a new request comes in', async () => {
+    const injector = TestBed.inject(Injector);
+    const appRef = TestBed.inject(ApplicationRef);
+    let unsub = false;
+    const request = signal(1);
+    const res = rxResource({
+      request,
+      loader: ({request}) =>
+        new Observable((sub) => {
+          if (request === 2) {
+            sub.next(true);
+          }
+          return () => {
+            if (request === 1) {
+              unsub = true;
+            }
+          };
+        }),
+      injector,
+    });
+
+    // Wait for the resource to reach loading state.
+    await waitFor(() => res.isLoading());
+
+    // Setting request = 2 should cancel request = 1
+    request.set(2);
+    await appRef.whenStable();
+    expect(unsub).toBe(true);
+  });
+});
+
+async function waitFor(fn: () => boolean): Promise<void> {
+  while (!fn()) {
+    await new Promise((resolve) => setTimeout(resolve, 1));
+  }
+}