diff --git a/asv/commands/preview.py b/asv/commands/preview.py
index 0a2baace3..abe899d20 100644
--- a/asv/commands/preview.py
+++ b/asv/commands/preview.py
@@ -1,7 +1,7 @@
 # Licensed under a 3-clause BSD style license - see LICENSE.rst
 
-from six.moves import SimpleHTTPServer, socketserver
-
+import socketserver
+import http.server
 import errno
 import os
 import random
@@ -84,9 +84,9 @@ def run_from_conf_args(cls, conf, args):
     def run(cls, conf, port=0, browser=False):
         os.chdir(conf.html_dir)
 
-        class Handler(SimpleHTTPServer.SimpleHTTPRequestHandler):
+        class Handler(http.server.SimpleHTTPRequestHandler):
             def translate_path(self, path):
-                path = SimpleHTTPServer.SimpleHTTPRequestHandler.translate_path(
+                path = http.server.SimpleHTTPRequestHandler.translate_path(
                     self, path)
                 return util.long_path(path)
 
diff --git a/asv/graph.py b/asv/graph.py
index 7f1432935..60f31632d 100644
--- a/asv/graph.py
+++ b/asv/graph.py
@@ -3,8 +3,6 @@
 import os
 import traceback
 import math
-from six.moves import xrange
-
 from . import util
 from . import step_detect
 
@@ -183,7 +181,7 @@ def mean_axis0(v):
             if not v:
                 return [None] * self.n_series
             return [mean_na(x[j] for x in v)
-                    for j in xrange(self.n_series)]
+                    for j in range(self.n_series)]
 
         # Average data over commit log
         val = []
@@ -196,14 +194,14 @@ def mean_axis0(v):
 
         # Discard missing data at edges
         i = 0
-        for i in xrange(len(val)):
+        for i in range(len(val)):
             if any(not is_na(v) for v in val[i][1]):
                 break
         else:
             i = len(val)
 
         j = i
-        for j in xrange(len(val) - 1, i, -1):
+        for j in range(len(val) - 1, i, -1):
             if any(not is_na(v) for v in val[j][1]):
                 break
 
@@ -454,7 +452,7 @@ def resample_data(val, num_points=RESAMPLED_POINTS):
 
     new_val = []
     j = 0
-    for i in xrange(min_revision + step_size, max_revision + step_size, step_size):
+    for i in range(min_revision + step_size, max_revision + step_size, step_size):
         chunk = []
         while j < len(val) and val[j][0] < i:
             chunk.append(val[j][1])
diff --git a/asv/plugins/regressions.py b/asv/plugins/regressions.py
index 5e2b6cc30..1d43c7d45 100644
--- a/asv/plugins/regressions.py
+++ b/asv/plugins/regressions.py
@@ -3,9 +3,7 @@
 import re
 import itertools
 import datetime
-
-from six.moves.urllib.parse import urlencode
-
+import urllib.parse
 from ..results import iter_results
 from ..console import log
 from ..publishing import OutputPublisher
@@ -153,7 +151,7 @@ def _save_feed(cls, conf, benchmarks, data, revisions, revision_to_hash):
                     params['commits'] = '{0}-{1}'.format(revision_to_hash[rev1],
                                                          revision_to_hash[rev2])
 
-                link = 'index.html#{0}?{1}'.format(benchmark_name, urlencode(params))
+                link = 'index.html#{0}?{1}'.format(benchmark_name, urllib.parse.urlencode(params))
 
                 try:
                     best_percentage = "{0:.2f}%".format(100 * (last_value - best_value) / best_value)
diff --git a/asv/results.py b/asv/results.py
index 43ea2c95f..2f3d2b8d1 100644
--- a/asv/results.py
+++ b/asv/results.py
@@ -8,8 +8,6 @@
 import itertools
 import hashlib
 import datetime
-from six.moves import zip as izip
-
 from . import environment
 from .console import log
 from .machine import Machine
@@ -169,7 +167,7 @@ def _compatible_results(result, result_params, params):
     # Pick results for those parameters that also appear in the
     # current benchmark
     old_results = {}
-    for param, value in izip(itertools.product(*result_params), result):
+    for param, value in zip(itertools.product(*result_params), result):
         old_results[param] = value
 
     new_results = []
diff --git a/asv/step_detect.py b/asv/step_detect.py
index f392b9fdb..8f0ecb744 100644
--- a/asv/step_detect.py
+++ b/asv/step_detect.py
@@ -361,8 +361,6 @@
 import math
 import collections
 import heapq
-import six
-
 try:
     from . import _rangemedian
 except ImportError:
@@ -938,7 +936,7 @@ def rolling_median_dev(items):
     try:
         while True:
             # Odd
-            v = six.next(s)
+            v = next(s)
             min_heap_sum += v
             v = -heapq.heappushpop(min_heap, -v)
             min_heap_sum -= v
@@ -949,7 +947,7 @@ def rolling_median_dev(items):
             yield (max_heap[0], d)
 
             # Even
-            v = six.next(s)
+            v = next(s)
             max_heap_sum += v
             v = heapq.heappushpop(max_heap, v)
             max_heap_sum -= v
diff --git a/asv/util.py b/asv/util.py
index a21a9b491..b89b08e14 100644
--- a/asv/util.py
+++ b/asv/util.py
@@ -23,10 +23,6 @@
 import operator
 import collections
 import multiprocessing
-
-import six
-from six.moves import xrange
-
 from .extern import minify_json
 
 
@@ -250,7 +246,7 @@ def human_time(seconds, err=None):
         # nan
         return "n/a"
 
-    for i in xrange(len(units) - 1):
+    for i in range(len(units) - 1):
         if scale < units[i + 1][1]:
             str_time = human_float(seconds / units[i][1], 3, significant_zeros=True)
             if err is None:
@@ -904,7 +900,7 @@ def update_json(cls, path, api_version, compact=False):
             "No version specified in {0}.".format(path))
 
     if d['version'] < api_version:
-        for x in six.moves.xrange(d['version'] + 1, api_version + 1):
+        for x in range(d['version'] + 1, api_version + 1):
             d = getattr(cls, 'update_to_{0}'.format(x), lambda x: x)(d)
         write_json(path, d, api_version, compact=compact)
     elif d['version'] > api_version:
@@ -1192,7 +1188,7 @@ def _remove_readonly(func, path, exc_info):
                 pass
 
         # Reraise original error
-        six.reraise(*exc_info)
+        raise
 
     def long_path_open(filename, *a, **kw):
         return open(long_path(filename), *a, **kw)
diff --git a/test/test_results.py b/test/test_results.py
index 8bccc5739..380677b56 100644
--- a/test/test_results.py
+++ b/test/test_results.py
@@ -4,9 +4,6 @@
 import datetime
 import shutil
 from os.path import join
-
-import six
-
 from asv import results, runner, util
 import pytest
 from .tools import example_results # noqa F401 needed to load fixtures (see #1030)
@@ -31,7 +28,7 @@ def test_results(tmpdir):
     duration = 1.5
 
     resultsdir = join(tmpdir, "results")
-    for i in six.moves.xrange(10):
+    for i in range(10):
         r = results.Results(
             {'machine': 'foo',
              'arch': 'x86_64'},
diff --git a/test/test_web.py b/test/test_web.py
index dc1f6d1a3..cb0ef1ba7 100644
--- a/test/test_web.py
+++ b/test/test_web.py
@@ -7,7 +7,7 @@
 import contextlib
 from os.path import join, abspath, dirname
 
-from six.moves.urllib.parse import parse_qs, splitquery, splittag
+import urllib.parse
 
 import pytest
 import asv
@@ -320,9 +320,9 @@ def test_web_summarylist(browser, basic_html):
         assert m, cur_row2.text
 
         # Check link
-        base_href, qs = splitquery(base_link.get_attribute('href'))
-        base_url, tag = splittag(base_href)
-        assert parse_qs(qs) == {'ram': ['128GB'], 'cpu': ['Blazingly fast'],
+        base_href, qs = urllib.parse.splitquery(base_link.get_attribute('href'))
+        base_url, tag = urllib.parse.splittag(base_href)
+        assert urllib.parse.parse_qs(qs) == {'ram': ['128GB'], 'cpu': ['Blazingly fast'],
                                 'NUL': ['[none]']}
         assert tag == 'params_examples.track_find_test'
 
diff --git a/test/test_workflow.py b/test/test_workflow.py
index 3a24a3d73..06ca09ab9 100644
--- a/test/test_workflow.py
+++ b/test/test_workflow.py
@@ -8,7 +8,6 @@
 import datetime
 import json
 
-import six
 import pytest
 
 from os.path import abspath, dirname, join, isfile, relpath
@@ -122,7 +121,7 @@ def test_run_publish(capfd, basic_conf):
     with open(filename, 'r') as fp:
         data = json.load(fp)
         assert len(data) == 2
-        assert isinstance(data[0][0], six.integer_types)  # revision
+        assert isinstance(data[0][0], int)  # revision
         assert len(data[0][1]) == 3
         assert len(data[1][1]) == 3
         assert isinstance(data[0][1][0], float)
diff --git a/test/tools.py b/test/tools.py
index acbd6048c..ad2229831 100644
--- a/test/tools.py
+++ b/test/tools.py
@@ -9,17 +9,16 @@
 import os
 import threading
 import time
-import six
 import tempfile
 import textwrap
 import sys
 import shutil
 import subprocess
+import http.server
 
 from os.path import abspath, join, dirname, relpath, isdir
 from contextlib import contextmanager
 from hashlib import sha256
-from six.moves import SimpleHTTPServer
 from filelock import FileLock
 
 
@@ -554,8 +553,8 @@ def ChromeHeadless():
         return selenium.webdriver.Chrome(options=options)
 
     ns = {}
-    six.exec_("import selenium.webdriver", ns)
-    six.exec_("from selenium.webdriver import *", ns)
+    exec("import selenium.webdriver", ns)
+    exec("from selenium.webdriver import *", ns)
     ns['FirefoxHeadless'] = FirefoxHeadless
     ns['ChromeHeadless'] = ChromeHeadless
 
@@ -563,7 +562,7 @@ def ChromeHeadless():
     if create_driver is None:
         src = "def create_driver():\n"
         src += textwrap.indent(driver_str, "    ")
-        six.exec_(src, ns)
+        exec(src, ns)
         create_driver = ns['create_driver']
 
     # Create the browser
@@ -596,10 +595,10 @@ def preview(base_path):
 
     """
 
-    class Handler(SimpleHTTPServer.SimpleHTTPRequestHandler):
+    class Handler(http.server.SimpleHTTPRequestHandler):
         def translate_path(self, path):
             # Don't serve from cwd, but from a different directory
-            path = SimpleHTTPServer.SimpleHTTPRequestHandler.translate_path(self, path)
+            path = http.server.SimpleHTTPRequestHandler.translate_path(self, path)
             path = os.path.join(base_path, os.path.relpath(path, os.getcwd()))
             return util.long_path(path)