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Questions about perturbation stimulation #553

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Jonyyqn opened this issue Mar 9, 2025 · 1 comment
Open

Questions about perturbation stimulation #553

Jonyyqn opened this issue Mar 9, 2025 · 1 comment

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@Jonyyqn
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Jonyyqn commented Mar 9, 2025

Very beautiful work! I have a question about simulated knockout. If I have a scRNA data and ChIP-seq data of transcription factor A (I can know the targeted gene of TF A), can I use scenicplus to simulate knockout or overexpression of TF A? If so, how do I do it?
@AbhinavSoni20191995
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Probably adding to this question, in general can we simulate over expression using SCENIC plus for specific TF-A and then perform pseudotime analysis?

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@AbhinavSoni20191995 @Jonyyqn