Clinical_Trials_Journals_Headlines.csv

Date,Source,Headlines,Teaser
  July 2002 ,Neurosurgical Focus,Outcome Measures for Clinical Trials in Neurotrauma,More than 40 years have passed since the first therapeutic trials were designed to test the ability of medications to improve outcome after severe TBI.
  June 2002 ,Southern Medical Journal,Selected Ongoing Clinical Trials,The following trials are designed to help physicians treat osteoporosis.
  July 2002 ,Medscape General Medicine,Medscape Psychopharmacology Today,Development process for drugs
  May 2002 ,Southern Medical Journal,Selected Ongoing Clinical Trials,The following trials are designed to help physicians treat thyroid dysfunction.
  June 2001 ,Abstracts in Hematology & OncologyTM,Urothelial Cancer: A Phase II Trial,A study evaluates efficacy and toxicity in previously untreated patients with advanced transitional cell carcinoma.
  January 2002 ,Southern Medical Journal,Selected Ongoing Clinical Trials,The following clinical trials are designed to help physicians treat diabetes as well as their potential complications.
  December 2001 ,Southern Medical Journal,The Female Patient: Selected Ongoing Clinical Trials,"The following trials are designed to help physicians keep up to date on the topics of cervical cancer, and more."
  June 2001 ,Seminars in Neurology,Clinical Trials in ALS: An Overview,"Women's participation in clinical trials, particularly those involving drugs, has been said to be both overrepresented and underrepresented. Studies of participation are compared and contrasted to elucidate some reasons for this contradiction."
  October 2001 ,Medscape General Medicine,Participation of Women in Clinical Trials of Drug Therapies,"Several new antifungal agents, including novel compounds in familiar classes and entirely new classes targeting previously untapped mechanisms, are in various stages of the drug development process."
  August 2001 ,Pharmacotherapy,Investigational Antifungal Agents,"Although the market for lipid-lowering medications is dominated by statins, the rise in statins predated the recent clinical trials supporting their use."
  June 2001 ,American Heart Journal,Randomized Clinical Trials and Recent Patterns in the Use of Statins,An excellent information Web site for clinical trials is now available.
  June 2001 ,American Heart Journal,Randomized Clinical Trials and Recent Patterns,"Some of the revolutionary drugs expected from human genome research may reach the pharmacy shelf sooner than expected, according to Francis Collins, MD, director of the National Human Genome Research Institute at the National Institutes of Health."
  March 2001 ,Cancer Control: Journal of the Moffitt Cancer Center,Resources on the Web - Searching for Information on Clinical Trials,Does the right of incarcerated prison and jail inmates to healthcare include access to clinical trials?
  January 2001 ,Pharmacy Today,Genome Map Spurring Drug Development Ahead of Schedule,Review the Office for Human Research Protections and FDA guidelines relevant to the conduct of HIV/AIDS clinical trials in correctional facilities.
  January 2001 ,The AIDS Reader®,HIV Clinical Trials in Correctional Settings: Right or Retrogression?,"Explore the advancements in clinical trial methodology, their utility in establishing treatment guidelines, and their impact on medical practice."
  January 2001 ,The AIDS Reader®,IRB/FDA Requirements Relevant to HIV/AIDS Clinical Trials,"During the past few years, a number of abuses have been committed in clinical trials."
  July 2007 ,International Journal of Clinical Practice,Recent Trials of Lipid Lowering,This narrative review summarises the key recent clinical trials of lipid lowering since 2004 and their implications for future patient care.
  May 2007 ,The British Journal of Dermatology,Methyl Aminolaevulinate-photodynamic Therapy,The efficacy and low risk of side-effects afforded by this therapy have resulted in high patient preference in clinical trials.
  May 2007 ,Nature Clinical Practice Oncology,A Remedy for Biomarker Addiction: Rational Anticancer Drug Development,The post-genomic era would seem to be an opportune time to rewrite the laws of cancer drug development. Where is the best place to start?
  April 2007 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Metabolic Effects of Protease Inhibitor-Sparing ART Regimens Given for HIV,"Lipids were higher in efavirenz-containing 3- or 4-drug regimens, whereas body circumference measurements increased then returned to baseline by 192 weeks in this strategy trial."
  April 2007 ,Nature Clinical Practice Oncology,How can we Improve Clinical Trials?,"Ideally, phase II oncology trials would quickly and efficiently identify genuine therapeutic advances. Strategies such as adding a 'real-world' cohort, amongst others, may facilitate improvement."
  August 2006 ,Nature Clinical Practice Neurology,Confounders to Spinal Cord Injury Clinical Trials,"Learn about the status of translational research in spinal cord injury trials, focusing on issues about concurrent use of methylprednisolone, and other potential confounders and possible solutions."
  February 2006 ,Alimentary Pharmacology & Therapeutics,7-Point Global Overall Symptom Scale for Dyspepsia,"At present, there is no consensus regarding the optimal method for measuring the severity of dyspepsia symptoms in clinical trials."
  January 2006 ,Nature Clinical Practice Oncology,Phase III Clinical Trials on Anti-VEGF Therapy for Cancer,"Read the contrasting results, as well as mechanisms underlying normalization of tumor vasculature, and the need for biomarkers and imaging techniques to guide patient selection and protocol designs."
  December 2004 ,Current Medical Research and Opinion,Measuring Symptom Response to Pharmacological Interventions,There is a clear need for a fully developed and validated tool for measuring the effects of therapeutic interventions on symptoms in COPD in clinical trials.
  May 2004 ,Pharmacotherapy,Single-Dose Pharmacokinetics of Sodium Ferric Gluconate Complex,Sodium ferric gluconate complex in sucrose injection (SFGC) is an iron formulation marketed in the United States as Ferrlecit.
  April 2004 ,Journal of Cardiovascular Electrophysiology,Drug-Induced Torsades de Pointes and Implications for Drug,"A review of the techniques and limitations of methods directed at drug-related phenomena, clinical trials, interpretation of ECGs, and evaluation of drug-related risks and benefits."
  March 2004 ,Current Medical Research and Opinion,Eletriptan for the Acute Treatment of Migraine:  Results of,"Eletriptan is a potent, selective 5-HT1B/1D agonist that has been studied in multiple double-blind, placebo-controlled clinical trials conducted on migraineurs in Europe, Australia, Canada and the US."
  March 2004 ,Arthritis Research & Therapy,"Equipoise, Design Bias, and Randomized Controlled Trials","The concept of 'equipoise', the 'uncertainty principle', has been represented as a central ethical principle of human experimentation."
  March 2004 ,Emerging Infectious Diseases,Clinical Trials and Novel Pathogens: Lessons From SARS,The recognition of SARS as a transmissible disease prompted international efforts to identify its cause and control its spread.
  January 2004 ,Wounds,Protocols for Advanced Technology Clinical Trials,"Products, devices, and materials for the treatment of chronic and problematic wounds have, during the course of the last two decades, progressed from simple dressings acting as protective coverings to more complex drugs and biological devices."
  October 2003 ,Dermatology Nursing,Dermatology Clinical Trials and Drug Development,Learn more about the drug development process and the role of the nurse.
  October 2003 ,Medscape General Medicine,Understanding Clinical Trials in Context,It is important for clinicians to know about the realities of the world of clinical studies and how to read between the data.
  August 2003 ,American Heart Journal,Most Hospitalized Older Persons Do Not Meet Enrollment Criteria,"A minority of hospitalized older persons with HF fit the profile of populations of clinical trials. There is an urgent need for research in HF for typical HF patients, including the very old."
  June 2003 ,Medscape General Medicine,"Subgroup Analysis, Sex Differences, and Clinical Trials",This report presents some of the current debate  regarding the design of clinical trials and the analysis  of resulting data to accurately and efficiently detect sex  differences.
  February 2003 ,Neurosurgical Focus,Convection-Enhanced Delivery in Clinical Trials,"The poor prognosis associated with malignant primary brain tumors treated with conventional therapies such as surgery, radiotherapy, and chemotherapy has led investigators to develop new innovative therapies."
  November 2008 ,Future Virology,Antiviral Drug Development: Progress and Pitfalls,The 21st International Conference on Antiviral Research witnessed a number of presentations on both novel and well-established viral targets. What are some of the new drug therapies in development?
  November 2008 ,The Medscape Journal of Medicine,The Myth of Equipoise in Phase 1 Clinical Trials,"The continued use of the ethically and scientifically invalid concept of ""equipoise"" in phase 1 clinical research trials undermines the ethics of research with human subjects."
  July 2008 ,Future Neurology,fMRI: Use In Early Alzheimer's Disease And In Clinical Trials,"Functional MRI (fMRI) provides a means to investigate alterations in brain function related to the earliest symptoms of AD, possibly before development of significant irreversible structural damage."
  July 2008 ,Future Virology,Antivirals: Current State of the Art,Antiviral drug development is now progressing at the pace antibiotics were 30 years ago. Learn more about current develops here.
  August 2008 ,Expert Review of Respiratory Medicine,Antituberculous Drug Development and Novel Drug Targets,"A review of the development status of new anti-tuberculous drugs is presented, such as nitroimidazoles, diarylquinolines, diarylquinolines and oxazolidinones."
  August 2008 ,Future Lipidology,Clinical Trials and Surrogate End Points: Lessons From the ENHANCE Trial,ENHANCE trial design and methods are explored in the context of related lipid lowering drug trials.
  June 2008 ,Europace,Anti-arrhythmic Drug Therapy for Atrial Fibrillation,Anti-arrhythmic drug therapy for atrial fibrillation has expanded. Explore the current slate of conventional and non-conventional agents in this thought provoking review.
  June 2008 ,Future Oncology,Status of Therapy for Chronic Myeloid Leukemia: Review of Drug Development,"Chronic myeloid leukemia treatment is relatively effective, but some problems have begun to emerge. Learn what the problems are and how newer generations of CML drug therapies may solve them."
  March 2008 ,Personalized Medicine,The Impact of US FDA Postapproval Tracking on Clinical Pharmacology,"Pending legislation could improve cooperation between drug sponsors, the federal government, and clinicians to ensure that genetic data are considered during crucial stages of drug development."
  February 2008 ,European Heart Journal,The Need for a Consensus Definition,This paper examines issues related to defining heart failure events in cardiovascular clinical trials and presents a definition to formally address this issue.
  January 2008 ,IRB: Ethics & Human Research,"Patient Knowledge, Perception & Likelihood of  Trial Partcipation",The impact of clinical trials is reviewed. What is the likelihood that a person will participate in a clinical trial; what are their perceptions regarding clinical research?
  November 2007 ,PLoS Medicine,Clinical Trials and Medical Care: Defining the Therapeutic Misconception,Therapeutic misconception describes a phenomenon when research participants do not appreciate that research and treatment are different but can a consistent definition be proposed and operationalized?
  September 2007 ,CHEST,Analyzing the Short-term Effect of Placebo Therapy in PAH,"Placebo therapy for pulmonary arterial hypertension (PAH) is common, but debated, in PAH treatment trials. What are the functional, hemodynamic, and clinical effects of placebo in adult PAH patients?"
  September 2007 ,Journal of the American Board of Family Medicine,Understanding the Quality Chasm for Hypertension Control in Diabetes,How can you translate innovations from clinical trials to routine practice to improve hypertension control in diabetes?
  August 2007 ,Nature Clinical Practice Oncology,Molecular Imaging can Accelerate Anti-Angiogenic Drug Development and Test,Angiogenesis is regulated by numerous molecular pathways that could serve as targets for molecular imaging. What is the role of molecular imaging in anti-angiogenic drug development?
  May 2007 ,British Journal of Cardiology,Clinical Trials Versus the Real World:The Example of Cardiac Rehabilitation,Is cardiac rehabilitation as currently practiced in the UK as effective as clinical trials may suggest?
  August 2007 ,Rheumatology,"Vitamins A, C, E and selenium in the treatment of arthritis","A systematic review of randomized clinical trials for the effectiveness of the antioxidant vitamins A, C, E or selenium or their combination in the treatment of arthritis."
  July 2007 ,AIDS,Should We Now Adopt the HIV-RNA < 50 Copy Endpoint for Clinical Trials?,These authors posit that HIV-RNA suppression < 50 copies/ml should be the standard efficacy endpoint in trials of naive and experienced patients as this endpoint has stronger durability over time.
  August 2007 ,IRB: Ethics & Human Research,Who Should Go First in Trials with Scarce Agents? The Views,"Access to drugs not approved by the FDA remains controversial. Even greater access is being called for, but the competing rights of the individual versus the state continue to complicate this issue."
  February 2007 ,Psychopharmacology Bulletin,Simple Options for Improving Signal Detection in Antidepressant Clinical,Effective antidepressants are not distinguished efficiently from placebos using signal detection. Might 3 easy-to-implement methodologies benefit signal detection and clinical trial design?
  November 2009 ,IRB: Ethics & Human Research,Competing Commitments in Clinical Trials,The goals of clinical research and clinical care are often at odds. This survey highlights the potential for clinical commitments of providers to undercut the requirements of research. 
  November 2009 ,Personalized Medicine,Will Personalized Medicine Help in 'Transforming' the Business of Healthcare?,"In order for personalized medicine to have its desired impact, innovative business models will be required to address competing financial interests."
  November 2009 ,Expert Review of Clinical Pharmacology,Novel Antibiotics for the Treatment of Staphylococcus aureus,"A leading cause of nosocomial infections, MRSA is a serious issue for all institutions. What are the newest drug therapies for this often fatal pathogen?"
  November 2009 ,European Journal of Heart Failure,Clinical Trials Update from the ESC Heart Failure Meeting 2009,"Here is information and a commentary on five recent trials with findings relevant to the pathophysiology, prevention, and treatment of heart failure."
  November 2009 ,International Journal of Clinical Rheumatology,What's New in Clinical Trials in Lupus?,"Recent trials have explored the efficacy of old, widely used therapies, as well as newer agents, to prevent lupus flares and for maintenance therapy."
  November 2009 ,Journal of the National Cancer Institute,Prospective Cost-effectiveness Analysis of Cetuximab in Metastatic Colorectal Cancer,Prospectively collected resource utilization and health utility data for patients with CRC in the CO.17 study who received best supportive care +/- cetuximab were assessed for cost effectiveness.
  October 2009 ,Clinical Lung Cancer, Cooperative Group Research Endeavors in Small-Cell Lung Cancer ,"This article discusses the scientific vision of various cooperative groups regarding small-cell lung cancer research, as presented at the 2008 International Lung Cancer Congress (ILCC)."
  October 2009 ,Nanomedicine,Neurodegenerative Disorders and Nanoformulated Drug Development,"Nanotechnology-driven therapies hold the promise of altering the clinical course and outcome of Alzheimer's disease and other common, debilitating and hard-to-treat neurodegenerative disorders.  "
  February 2009 ,Malaria Journal,Clinical Trials to Estimate the Efficacy of Preventive Interventions Against Malaria in Paediatric Populations,"How can trial design be improved and standardized to enable comparative evaluation of malaria control measures in pediatric populations, specifically with respect to the design of malaria vaccine trials?"
  August 2009 ,Annals of Surgery,Use of Emerging Oral Anticoagulants in Clinical Practice,This is an important review of clinical studies of the oral anticoagulants in preventing postoperative venous thromboembolism.
  February 2009 ,Nature Clinical Practice Gastroenterology & Hepatology,How to Critically Appraise an Article,"This review article presents a 10-step guide to the critical appraisal of research literature to assist clinicians in identifying relevant, high-quality studies to guide their clinical practice."
  January 2009 ,HIV Clinical Trials,Preparticipation Information on Posttrial Services of HIV Clinical Trials,Whether patients participate in clinical trials may hinge on whether they’ll receive medications or medical care after the trial ends. How often are retroviral drug trials providing this information?
  June 2009 ,Expert Review of Hematology,Optimal Treatment for Relapsing Patients With Hodgkin Lymphoma,Relapsed/refractory Hodgkin lymphoma (HL) is still a therapeutic challenge. What are some novel investigational treatments for relapsing patients?
  June 2009 ,Faculty of 1000,"A Call for More Transparency of Registered Clinical Trials on Endometriosis. Ranked ""Exceptional"" by F1000",The need for exposure of important research in endometriosisto the medical and public eyes is long overdue.
  May 2009 ,IRB: Ethics & Human Research,An Intervention to Improve Cancer Patients' Understanding of Early-Phase Clinical Trials,Could a computer-based informed consent intervention help clarify patients' expectations about a trial's purpose and benefit? 
  November 2008 ,Neurosurgical Focus,Protection and Repair of the Injured Spinal Cord,This article reviews current clinical trials that could revolutionize management of acute spinal injury.
  January 2009 ,IRB: Ethics & Human Research,Including Persons With Alzheimer Disease in Research on Comorbid Conditions,What is the appropriate balance between protecting Alzheimer patients from the potential risks of research while allowing them to participate in trials that could lead to medical benefit?
  December 2008 ,Kidney International,DRIVE it Home: The Case for Prospective Economic Data Collection in RCTs,The DRIVE and DRIVE-II trials evaluated the efficacy of IV ferric gluconate in anemic dialysis patients but how can we extrapolate these data to change public policy and reimbursement practices?
  November 2008 ,AIDS,HIV Clinical Trial Design for Antiretroviral Development,How can proper clinical trial design affect antiretroviral development?
  November 2008 ,Expert Review of Clinical Immunology,Inhaled Corticosteroids as Rescue Medication in Acute Severe Asthma,The clinical evidence regarding the use of inhaled corticosteroids in acute asthma patients are reviewed.
  January 2010 ,BMC Pharmacology,Antinociceptive Effects of Extracts from Pterodon pubescens ,A Brazilian medicinal plant has pain-relieving properties.
  February 2010 ,Expert Review of Hematology,Autologous Hematopoietic Stem Cell Transplantation in Autoimmune Diseases,"This article discusses the growing experience in the use of HSCT in various autoimmune diseases, including multiple sclerosis, Crohn’s disease, and systemic sclerosis."
  December 2009 ,BMC Clinical Pharmacology,Bioavailability of Different Ibuprofen Preparations,A phase I trial compares the absorption rates of different ibuprofen formulations.
  February 2010 ,AIDS Clinical Care,HIV Outcomes in the Clinic: Now as Good as in Clinical Trials,Example Teaser
  December 2009 ,Expert Review of Hematology,Acute Myeloid Leukemia Stem Cells: Seek and Destroy,This article reviews bench and translational research in leukemic stem cells and discusses how the data should be used to change the direction of developmental therapeutics and clinical trials in AML.
  February 2010 ,Journal Watch,HIV Outcomes in the Clinic: Now as Good as in Clinical Trials,"HIV treatment outcomes have significantly improved over the years, but by just how much?  "
  February 2010 ,Arthritis Research & Therapy,Molecular Therapies for Systemic Lupus Erythematosus: Clinical Trials and Future Prospects,Exploring new pharmacological options and therapeutic avenues for lupus: a focus on non-antibody molecular strategies. 
  January 2010 ,IRB: Ethics & Human Research,Bipolar Mania and Capacity to Consent: Recommendations for Investigators,What is the decisional capacity of individuals with bipolar mania and other mental disorders? 
  January 2010 ,PLoS Medicine,Are Patents Impeding Medical Care and Innovation?,"Is the current patent system actually stimulating biomedical research and innovation, or is it stifling it by raising costs and restricting access?"
  January 2010 ,American Journal of Health-System Pharmacy,Pharmacokinetics of Extended-Release Epidural Morphine Sulfate,How does extended-release epidural morphine compare with standard epidural morphine?
  January 2010 ,BMC Clinical Pharmacology,In Vivo Administration of BL-3050: Highly Stable Engineered PONI-HDL Complexes,A recombinant HDL-associated enzyme and its HDL complex may have a role in treating organophosphate poisoning and atherosclerosis.
  January 2010 ,BMC Pharmacology,Evaluation of Molecular Descriptors for Antitumor Drugs,Understanding chemical properties of these antineoplastic agents may lead to new drug designs.
  December 2009 ,The Nation's Health,New Books Showcase Ethical Issues in Public Health Practice,Ethical issues in public health research and practice now occupy a prominent place in the public health landscape. Two new books provide some guidance for students and professionals.
  December 2009 ,Expert Review of Gastroenterology and Hepatology,Therapeutic Vaccination and Novel Strategies to Treat Chronic HBV Infection,This study focuses on therapeutic vaccination in HBV and discusses potential ways to effect efficient restoration of virus specific immunity in patients with chronic HBV.
  December 2009 ,BMC Clinical Pharmacology,Interactions Between Transdermal Selegiline and Cocaine Infusion,"For potential treatment of cocaine dependence, researchers investigate whether an interaction exists between selegiline and cocaine."
  December 2009 ,The Hastings Center Report,A Tool to Strengthen The Doctor-Patient Relationship,"Comparative effectiveness can ""serve to protect us from our worst impulses and to nurture our very best ones,"" according to the author of this article. "
  December 2009 ,IRB: Ethics & Human Research,Voluntariness of Consent to Research,"Practice-based research networks are burgeoning, and offer an ideal venue for the study of common medical problems, but further maturation is needed for them to fulfill their promise."
  December 2009 ,Journal of the American Board of Family Medicine,Increasing the Role of Practice Networks in Medical Research,"Volunteering for research studies is laudable--and for heart failure patients, it may also be an independent prognostic variable."
  June 2010 ,BMC Clinical Pharmacology,Traumeel S for Pain Relief Following Hallux Valgus Surgery,Traumeel S for Pain Relief Following Hallux Valgus Surgery: A Randomized Controlled Trial
  May 2010 ,U.S. Pharmacist,LASIK Refractive Eye Surgery in the 21st Century,"This surgery is a fast, safe, and cost-effective alternative to glasses and contact lenses."
  May 2010 ,Expert Review of Clinical Pharmacology,Keeping the Rhythm: hERG and Beyond in Cardiovascular Safety Pharmacology,What is the relationship between the hERG ion channel and torsades de pointes?
  May 2010 ,Rheumatology,Lupus Clinical Trials: What Have We Learned So Far?,What treatments are on the horizon for lupus? This review looks at some potential options.
  May 2010 ,Expert Review of Clinical Pharmacology,K+ Channels in the Heart: New Insights and Therapeutic Implications,Will drugs targeting atrial K+ channels have decreased risk of proarrhythmia?
  May 2010 ,The Annals of Pharmacotherapy,Adverse Drug Events in Adult Patients Leading to ED Visits,"How commonly are adverse drug events responsible for ED visits, and which drugs are most often involved?"
  May 2010 ,BMC Clinical Pharmacology,EVITA: A Tool for the Early Evaluation of Pharmaceutical Innovations With Regard to Therapeutic Advantage,This screening tool serves to evaluate the additional therapeutic value of new drugs compared to similar drugs.
  May 2010 ,American Heart Journal,Bridging the Gap Between Clinical Trials of Antiplatelet Therapies and Applications Among Elderly Patients,The paradox of both clotting and bleeding easily keeps elderly patients out of trials studying acute coronary syndromes and peri-PCI treatments. How can extrapolate data for this growing population?
  March 2010 ,Malaria Journal,Engaging Diverse Communities Participating in Clinical Trials: Case Examples From Across Africa,Getting local communities in Africa involved in malaria research can pay big dividends.
  April 2010 ,BMC Pharmacology,BIAdb: A Curated Database of Benzylisoquinoline,A new database may assist those researching drug discoveries based on natural products.
  May 2010 ,Current Opinion in Pulmonary Medicine,New Drugs and New Regimens for the Treatment of TB: Review of Drug ,"The authors review the problems related to drug-resistant TB, describe recent advances in the development of new drugs, and discuss implications for control programs."
  March 2010 ,BMC Pharmacology,Targeting Ligand-Gated Ion Channels in Neurology and Psychiatry,"Could ""magic shotguns,"" drugs capable of interacting with multiple targets, be alternatives to ""magic bullets,"" drugs with high-specificity?"
  April 2010 ,American Journal of Health-System Pharmacy,Facilitating Evidence-Based Prescribing for Unlabeled Use of Medications,Pharmacists should be educators about off-label use of medication.
  April 2010 ,Journal Watch,A Critical Look at Flu Vaccine Studies,Influenza vaccine efficacy studies can yield misleading data if conducted at the wrong time.
  March 2010 ,Journal of Pediatric Psychology,Research and Practice: The Role of the Journal of Pediatric Psychology,This editorial outlines The Journal of Pediatric Psychology's current and future directions in publishing clinically relevant work.
  April 2010 ,American Journal of Health-System Pharmacy,Significant Publications on Infectious Diseases Pharmacotherapy in 2008,Read summaries of important articles on infectious disease therapy. 
  March 2010 ,Expert Review of Proteomics,Role for Protein-Protein Interaction Databases in Human Genetics,"Since protein databases are now widely available, how does this impact research on protein-protein interactions?"
  January 2010 ,BMC Nephrology,Follow-up of Phase I Trial of Adalimumab and Rosiglitazone in FSGS,Antifibrotic therapy for a defined period of time may be a viable strategy to preserve kidney function in patients with resistant focal segmental glomerulosclerosis.
  March 2010 ,Annals of Oncology,Randomized Placebo-Controlled Study of Tamoxifen After Adjuvant Chemo,Premenopausal women with early breast cancer could have improved 5-year survival when Tamoxifen is used after adjuvant chemotherapy.
  February 2010 ,BMC Clinical Pharmacology,A Systematic Review of Analgesics After Traumatic or Orthopaedic Surgery,A review evaluates the quality of trials on analgesic use post orthopedic or traumatic surgery.
  August 2010 ,BMC Pharmacology,Quantitative In Vitro and In Vivo Pharmacological Profile of CE-178253,Will this cannabinoid receptor antagonist be a possible treatment for obesity?
  September 2010 ,Europace,Implantable Electrical Devices for Prevention of SCD,A web-based registry was instituted to collect data for all ICDs implanted in a region with around 4.3 million inhabitants. Do registry results show adherence to guidelines?
  September 2010 ,Journal of Pediatric Psychology,A Call for Replications of Research in Pediatric Psychology,The author addresses the need for more frequent research replications in the field of pediatric psychology.
  August 2010 ,American Journal of Health-System Pharmacy,Evaluating Equivalence and Noninferiority Trials,Do you know how to interpret negative results from a superiority trial
  July 2010 ,AccessMedicine from McGraw-Hill,Pediatric Pharmacotherapy Part 1: The History of Pediatric Drug Therapy,"For far too long, ethical and practical problems minimized the use of children in drug studies; therefore, much of pediatric pharmacotherapy even today is based more on error than trial ."
  July 2010 ,Annals of Oncology,Absolute Benefits of Medical Therapies for Breast and CRC,RCTs may be arriving at a point-of-diminishing-return for breast and colorectal cancer treatment initiatives.
  August 2010 ,Future Microbiology,TMC207: The First Compound of a New Class of Potent Anti-Tuberculosis Drugs,"TMC207, a new compound with a novel mechanism of action, may be a breakthrough in the fight against drug-sensitive and drug-resistant TB."
  July 2010 ,BMC Pharmacology,Prediction of Cytochrome P450 Isoform Responsible for Metabolizing a Drug,Is a drug metabolized by CYP? New research is answering this question quickly and accurately.
  August 2010 ,Journal of Cardiovascular Electrophysiology,The DIONYSOS Study,A comparison of the benefit/risk ratio of dronedarone and amiodarone is made for patients with atrial fibrillation.
  August 2010 ,American Heart Journal,Study Design and Rationale of a Comparison of Prasugrel and Clopidogrel in Medically Managed Patients ,"The largest randomized clinical trial to date, focusing exclusively on medically managed NSTE ACS patients, will provide important information regarding the optimal approach to oral antiplatelet therapy for this high-risk population."
  May 2010 ,IRB: Ethics & Human Research,The Evolution of Consent Forms for Research: A Quarter Century of Changes,How has the consent form evolved over the past few decades? This new study explores the changes.
  July 2010 ,Journal of the American Board of Family Medicine,What Do We Get From Participating in Practice-based Research Networks?,The author makes a case for practice-based research as a good fit in a health care environment with new interest in translational research at one end and health care reform at the other.
  May 2010 ,Journal of Hospital Medicine,Comparative Effectiveness Research: Implications for Hospital Medicine,Learn how comparative effectiveness research  is different from standard research that hospitalists use to inform their clinical decision-making.
  June 2010 ,American Heart Journal,Unexplained International Differences After AMI and Fibrinolytic Therapy,Disparity between nations may be part of the learning curve for large-scale international trials.
  June 2010 ,Nanomedicine,Nanomedicinal Strategies to Treat Multidrug-Resistant Tumors,Are nano-based drug delivery systems the answer to multi-drug resistance in solid tumor chemotherapy?
  June 2010 ,Critical Care Medicine,Plasma Interleukin-8 is not an Effective Risk Stratification Tool for Adults ,"Plasma biomarkers provide a potentially useful approach to risk stratification of patients before enrollment in clinical trials, but may not be ready for prime time use across populations."
  April 2010 ,Expert Review of Cardiovascular Therapy,Aptamers: the Emerging Class of Future Anticoagulation for Vascular Disease,"Aptamers are known for their high potency, low safety concerns, and an excellent toxicology profile. Learn more about this up and coming class of anticoagulants in this review."
  November 2010 ,Oncology Nursing Forum,Initiative to Standardize a Clinical Trial Educational Program ,Improving the process of assisting oncology patients in making informed decisions about clinical trials pays dividends for all.
  October 2010 ,The Pediatric Infectious Disease Journal,Immunogenicity and Safety of Trivalent Two Inactivated Influenza Vaccines,Is the inactivated influenza vaccine Fluarix--currently approved only for children older than 3 years--as safe and effective as Fluzone in children under that age?
  October 2010 ,American Journal of Pharmaceutical Education,Presenting and Evaluating Qualitative Research,"Qualitative data includes diaries, photographs, and questionnaires."
  October 2010 ,Nanomedicine,Polymer-Drug Conjugates For Novel Molecular Targets,"Polymer-drug conjugates are now used in cancer therapy, but potential future applications are far-ranging, including diabetes, hypertension, infections, digestive tract diseases and inflammation."
  October 2010 ,Health and Quality of Life Outcomes,Patient Reported Outcomes: Looking Beyond the Label Claim,Should patient reported outcomes be viewed as an essential complement to traditional clinical evidence in pharmaceutical product development?
  October 2010 ,European Heart Journal,Shock in AMI: The Cape Horn for Trials?,"This review outlines the underlying causes, pathophysiology, and treatment of cardiogenic shock in AMI."
  October 2010 ,Journal of the National Cancer Institute,"Large Trials, Small Gains: Is Change on the Way? ",Proposed fixes for important aspects of the cancer research infrastructure may help to fill in the cracks of a stressed foundation.
  October 2010 ,BMC Pharmacology,Hematopoietic Stem Cells Exhibit a Specific ABC Transporter Gene Profile ,Is stem cell function dependent on specific ABC transporter gene expression?
  October 2010 ,Nanomedicine,Surface-Modified PLGA-Based Nanoparticles Can Deliver Virus-Like Particles,"A new nanocarrier, specifically engineered for the association and transmucosal delivery of a virus-like particle, is a promising novel approach for vaccine delivery."
  October 2010 ,Pediatric Pharmacotherapy,Adverse Drug Events in Children: Recent Cases from the Medical Literature,This article summarizes several important pediatric adverse drug event case reports and clinical trials published within the past year.
  October 2010 ,Future Neurology,Latrepirdine for Alzheimer's Disease: Trials and Tribulations,"Early studies showed potential for latrepirdine in treatment of Alzheimer's disease, but results of subsequent trials have been discouraging. Why did it fail? "
  October 2010 ,Pharmacotherapy,Evaluation of Renal Drug Dosing,Are clinicians routinely using eGFR or MDRD?
  October 2010 ,Skin Therapy Letter,Nanodermatology: A Bright Glimpse Just Beyond the Horizon - Part I,"An overview of exciting new developments in nanotechnology as it relates to skin care, not only for cosmetics but for diagnostics and therapeutic agents as well."
  October 2010 ,Faculty of 1000,The Reality of Drug Shortages--The Case of The Injectable Agent Propofol,The development of methods to counteract drug shortages is crucial before patient care is adversely affected
  October 2010 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,The Association Between Money and Opinion in Academic Emergency Medicine,What influence does grant money have on academic opinion leaders?
  October 2010 ,Arthritis Research & Therapy,Efficacy Assessed in Follow-ups of Clinical Trials: Methodological Conundrum,Are certain patients with rheumatoid arthritis more likely to get osteoporosis than others?
  September 2010 ,Expert Review of Clinical Immunology,RAPID and FAST4WARD Trials: Certolizumab Pegol for Rheumatoid Arthritis,Rheumatoid arthritis treatment options are rapidly expanding and this article will bring you up-to-speed.
  September 2010 ,Journal Watch,BRAF and Melanoma: Taking It Personally,"In this exciting and widely publicized study, more than 80% of melanoma patients with the BRAF mutation responded to treatment with the novel agent PLX4032."
  September 2010 ,Arthritis Research & Therapy,Efficacy Assessed in Follow-ups of Clinical Trials: Methodological Conundrum,What types of problems can arise when comparing results of various randomized clinical trials?
  September 2010 ,Expert Review of Neurotherapeutics,Vitamin D and Multiple Sclerosis: What Are the Guidelines for a Reliable Clinical Trial?,"Some studies have shown a causal relationship between low serum vitamin D levels and disease activity in MS, but were their methods rigorous enough?"
  January 2011 ,Personalized Medicine,Biobanking in Pediatrics,A biobank is a collection of tissue and health information used for research.
  January 2011 ,Personalized Medicine,Genetics of Osteoporosis: Perspectives for Personalized Medicine,Can pharmacogenomics help mitigate the risk of osteoporosis?
  November 2010 ,Personalized Medicine,Pharmacogenomics and Adverse Drug Reactions,Can we identify patients with predispositions for ADRs?
  January 2011 ,Expert Review of Clinical Pharmacology,Hydrogen Sulfide in the Endocrine and Reproductive Systems,Some endocrine disorders are associated with changes in hydrogen sulfide biosynthesis.
  December 2010 ,International Journal of Clinical Practice,Update on Treatments for Premature Ejaculation,Review current and investigational strategies for the therapeutic management of premature ejaculation. What's the best approach?
  December 2010 ,Critical Care,H-2 Antagonists vs Sucralfate in Ventilated Patients,The more efficacious treatment for stress ulcer prevention in ventilated patients may also have an impact on VAP.
  December 2010 ,Nanomedicine,Biodistribution of Polymersomes Into Oral Squamous Cell Carcinoma Cells,"This study looks at the potential of polymersomes to deliver chemotherapeutic agents or gene therapy intracellularly in oral squamous cell carcinoma, a common cancer with a poor prognosis."
  November 2010 ,BMC Family Practice,Pregabalin Safety and Efficacy in Older Patients With Neuropathic Pain,"Pregabalin has been shown to be safe and effective for management of chronic neuropathic pain younger patients, but what about in those over 65 years of age?"
  October 2010 ,Annals of Oncology,Optimal Treatment for Relapsing Ovarian Cancer,The most promising strategies being used in RCTs are featured in this review of relapsed ovarian cancer treatment.
  November 2010 ,Cardiovascular Ultrasound,Standardized Ultrasound Evaluation of Carotid Stenosis for Clinical Trials,"Many clinical trials of carotid artery repair are underway, but how should results be evaluated? UWURC proposes a uniform examination protocol using duplex Doppler velocimetry."
  November 2010 ,Skin Therapy Letter,Nanodermatology: A Glimpse of Caution Just Beyond the Horizon - Part II,"While there are many exciting new uses of nanotechnology in dermatology, there are many toxicity concerns that must addressed before nanomedicine can reach its full potential."
  November 2010 ,Journal of the National Cancer Institute,Improved Endpoints for Cancer Immunotherapy Trials,Immunotherapeutic mechanisms of action call for refined treatment endpoints in cancer therapy.
  November 2010 ,Annals of Clinical Microbiology and Antimicrobials,Effects of Antibacterial Mineral Leachates on E. Coli and MRSA,Certain mineral mixtures and their aqueous leachates have demonstrated in vitro antibacterial activity. What is their mechanism of action?
  November 2010 ,Nanomedicine,Antiangiogenic Nanotherapy With Methotrexate for Inflammatory Arthritis,"In this animal study, fumagillin nanoparticles showed promise as a treatment of rheumatoid arthritis when combined with a conventional antirheumatic drug."
  November 2010 ,Neurosurgical Focus,Acromegaly: Review of Current Medical Therapy and New Drugs on the Horizon,"New somatostatin analogs, novel chimeric ligands, and extended delivery implants--all currently in clinical trials--bring new hope for sufferers of acromegaly."
  November 2010 ,American Heart Journal,Are Changes in Carotid Intima-Media Related to Risk of Nonfatal MI? ,Carotid intima-media thickness may not be the best surrogate endpoint in RCTs. Learn why.
  November 2010 ,Journal Watch,Mammography Revisited: Does Screening Lower Breast Cancer-Related Mortality?,"According to a Norwegian study, screening mammography may not lower mortality by as much as previously thought. "
  March 2011 ,American Heart Journal,Review of Event Rates in Diabetes Clinical Trials,Just how influential are these two variables on cardiovascular event rates in diabetes trials? 
  March 2011 ,Journal of Participatory Medicine,Citizen Science Genomics for Preventive Medicine Research,"This paper proposes a research model for conducting citizen science genomics, integrating personal genomic data with physical biomarker data to be applied in large-scale preventive medicine studies."
  March 2011 ,Journal of the National Cancer Institute,QoL Measurement in RCTs in Breast Cancer ,When do measures of self-reported symptoms have the most utility in breast cancer research?
  February 2011 ,BMC Clinical Pharmacology,Pharmacokinetics of Phenoxodiol,This isoflavone is being investigated in prostate and breast cancer.
  March 2011 ,Nanomedicine,Efficient Gene Delivery by EGF-Lipoplexes In Vitro and In Vivo,Could EGF-receptor targeted lipoplexes serve as alternatives to viral nanovectors for gene therapy?
  February 2011 ,Nature Reviews Neurology,Paving the Way for Alzheimer Disease Drug Development,Advances in Alzheimer disease research during 2010 have identified promising novel diagnostic tools and therapeutic targets. Read about four of the most exciting studies in this review.
  March 2011 ,Cancer Nursing,Improving Hospice Outcomes Through Systematic Assessment,The efficacy of systematic feedback from standardized assessment tools for hospice patient-caregiver dyads is evaluated.
  February 2011 ,Journal of the National Cancer Institute,Randomized Trial of Induction Chemotherapy in Metastatic CRC,What does this updated analysis of a first-line treatment trial for patients with metastatic CRC tell us about induction?
  February 2011 ,Nanomedicine,Self-Nanoemulsifying Drug Delivery Systems,Learn about self-nanoemulsifying drug delivery systems--one of the many ways by which nanotechnology can improve delivery and therapeutic efficacy of drugs. 
  February 2011 ,Future Microbiology,Antimalarial Drugs: Modes of Action snd Mechanisms of Resistance,"An examination into the drug resistance mechanisms at work in P. falciparum, the malaria parasite species which accounts for 90% of deaths worldwide."
  March 2011 ,Current Opinion in Psychiatry,Placebo Response In Clinical Trials With Schizophrenia Patients,Excessive placebo response is an important factor in the failure rate of clinical trials for schizophrenia drugs. What are the potential causes and what steps can be taken to minimize this effect?
  February 2011 ,Journal of the National Cancer Institute,"When Are ""Positive"" Oncology Trials Truly Positive? ",The importance of clinical significance is discussed in comparison to statistical significance in clinical trials for cancer treatment.
  February 2011 ,Headache,Clinical Efficacy of Telcagepant in Migraine,The calcitonin gene-related peptide antagonist telcagepant may be a breakthrough in migraine therapy because of its novel approach--but is it as effective as more traditional drugs?
  January 2011 ,Nanomedicine,Engineering Nanomedicines for Improved Melanoma Therapy,"The search for better outcomes in malignant melanoma has led to new immunotherapies and chemotherapeutic agents, but more effective delivery methods are urgently needed. Nanotechnology provides hope."
  January 2011 ,Journal of the National Cancer Institute,Comparative Effectiveness of Prostate Cancer Treatments,Authors evaluated methods for addressing confounding in treatment and survival of patients with early-stage prostate cancer in observational data. 
  January 2011 ,IRB: Ethics & Human Research,The Globalization of Clinical Trials: The Promise and Perils ,What happens when clinical trials get outsourced to foreign countries? This new book explores the issues.
  January 2011 ,Journal of the National Cancer Institute,Assessment of Clinical Validity of a Breast Cancer Risk Model ,A synergistic approach to risk profiling may provide the most useful information - from both clinical and genetic variables.
  January 2011 ,Current Opinion in Allergy and Clinical Immunology,Common Variable Immunodeficiency ,"This review highlights the most important publications of the past year, with an emphasis on novel findings in genetics and the immunophenotype of CVID."
  January 2011 ,Expert Review of Clinical Pharmacology,Therapeutic Potential of Hydrogen Sulfide-Releasing Hybrids,These gasotransmitter hybrids have promise for treating inflammation.
  April 2011 ,Immunotherapy,Cellular Immunotherapy for High-Grade Glioma,"The outcome for patients with glioblastoma multiforme remains poor, but new cellular strategies may brighten the outlook."
  April 2011 ,Headache,"MAP0004, Orally Inhaled DHE for Acute Treatment of Migraine","This RCT looks at the efficacy of MAP0004, an orally inhaled formulation of dihydroergotamine for the treatment of acute migraine. How did it fare against placebo?"
  April 2011 ,Journal of the National Cancer Institute,Proposed New Clinical Trial System at NCI Gets Mixed Reviews,Oncology community leaders got a look at the National Cancer Institute's proposal for renovating its clinical trial system and found fundamental changes that will undoubtedly impact clinical research and practice.
  May 2011 ,Current Opinion in Psychiatry,"Ethical, Legal and Social Issues in Alcohol and Drug Research","Research projects involving alcohol and drugs present many ethical, legal and social aspects that need to be taken into consideration, especially in relation to the informed consent process."
  April 2011 ,Journal of the American College of Cardiology,Predictors of New-Onset Diabetes in Patients Treated With Atorvastatin,"High dose statins may be associated with the onset of diabetes, at least for some. Who is most at risk and why?"
  April 2011 ,Expert Review of Anticancer Therapy,Targeted Therapy for SCC of the Head and Neck,"New treatments, especially targeted agents and novel combined regimens, are being evaluated in ongoing clinical trials for SCCHN."
  April 2011 ,IRB: Ethics & Human Research,(Mis)Understanding Exploitation,This article explores the issue of exploitation in the area of biomedical research.
  April 2011 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Prophylactic Antibiotics for Dog Bites with Refined Cost Model,"Does it make economic sense to treat all dog bite patients with antibiotics, even if the risk of infection is unknown?"
  April 2011 ,Cancer Control: Journal of the Moffitt Cancer Center,Direction of Future Clinical Trials for Ovarian Cancer,"Over the last several decades, clinical trials have defined the therapeutic approach for ovarian cancer. Future trials promise new directions."
  April 2011 ,Personalized Medicine,The N-of-1 Clinical Trial,Single subject studies may help advance personalized medicine.
  March 2011 ,Nanomedicine,Graphene in Biomedicine: Opportunities and Challenges,"Graphene, an allotrope of carbon, has exciting potential for various biomedical applications, including drug delivery, cancer therapies and biosensing.  "
  March 2011 ,Journal of the American Board of Family Medicine,Postpartum Diagnostic Depression Interview is Problematic,Using a formal DSM-IV-based interview to identify depression in postpartum mothers may have serious flaws that could lead to underdiagnosis
  March 2011 ,Journal Watch,Cell-Culture-Derived Influenza Vaccine: Safe and Efficacious,New approaches to influenza vaccine production are needed in order to meet high demand. Is a cell-culture-derived vaccine as safe and effective as egg-based?
  March 2011 ,Expert Review of Clinical Pharmacology,Regulation of Appetite to Treat Obesity,How do medications alter the desire to eat?
  March 2011 ,HIV Medicine,HIV/AIDS Patients and Clinical Trials in the HAART Era,Who is most likely to sign up to participate in an HIV/AIDS clinical trial? This study looks at the data.
  March 2011 ,Expert Review of Clinical Pharmacology,Corticosteroids in Brain Cancer Patients,How does dexamethasone reduce peritumoral edema?
  March 2011 ,Nature Reviews Clinical Oncology,Methodological Challenges for Personalized Cancer Therapies,"Many clinical trials of targeted therapies have produced disappointing results, but biomarker identification and other strategies outlined in this article should help to improve outcomes."
  March 2011 ,Expert Review of Neurotherapeutics,A New Treatment Algorithm in Multiple Sclerosis,How do the newly approved and emerging oral therapies for multiple sclerosis fit into existing treatment strategies? And how might a new treatment algorithm evolve in the near future?
  March 2011 ,Nanomedicine,Nanocarriers for Pulmonary Administration of Peptides and Proteins,"Peptides and proteins are an important class of therapeutic agents, but their efficient and safe administration has proven challenging. Could inhaled delivery via nanocarriers be the answer?"
  August 2011 ,Annals of Oncology,Pancreatic Cancer Treatment and Research,Learn about the most important strides that have been made in improving outcomes with pancreatic cancer therapy.
  July 2011 ,U.S. Pharmacist,The Pharmacist's Role in Preventing Antibiotic Resistance,What is antibiotic stewardship?
  August 2011 ,International Journal of Clinical Rheumatology,Promising Developments in Osteoporosis Treatment,Promising new treatments for osteoporosis are under study.
  July 2011 ,Future Microbiology,Antimicrobials for Bacterial Bioterrorism Agents,The efficacy of current antimicrobials against highly virulent pathogens that may be used in bioterrorism is limited. What current options and new strategies in drug development show promise?
  July 2011 ,Journal of Medical Case Reports,Case Report on Trial: Do You Swear to Tell the Truth?,"This editorial ponders the value of case reports. Can the medical community learn from one case? The answer--a resounding ""yes."""
  June 2011 ,Nanomedicine,Future of Nanomedicine: Obstacles and Remedies,"Although nanomedicine has the potential to revolutionize treatment for many diseases, it faces challenging economic, social and safety-related obstacles."
  June 2011 ,Future Microbiology,Therapeutic Options for Enterobacteriaceae Infections,Carbapenem resistance in Enterobacteriaceae is rapidly becoming a serious problem. What other therapeutic options are available--and under investigation--to combat these infections?
  May 2011 ,American Nurse Today,Drug Therapy Gets Personal With Genetic Profiling,Understanding the effects of genetic variations on drug metabolism is the key to personalized drug therapy. This article will bring you up-to-speed in a hurry.
  June 2011 ,Journal of the National Cancer Institute,Radiologists Urge FDA To Accept PET-Based Criteria ,The FDA has accepted only CT scans and Response Evaluation Criteria in Solid Tumors/RECIST to date. What clinical impact might such a change have?
  June 2011 ,Personalized Medicine,Stem Cells in Drug and Toxicological Screening,Can stem cells be used to determine drug safety?
  June 2011 ,Headache,Evaluating Sex and Gender in Migraine and Headache Research,"Several hypotheses have been proposed to explain the sex differences observed in migraine and other headache disorders, and numerous studies conducted, but how valid are their findings?"
  June 2011 ,Journal of Cardiovascular Electrophysiology,Trends in Rhythm Control Therapies After AFFIRM and RACE Trials,Significant utilization changes were observed in the years following the publication of the AFFIRM and RACE trials. What has the net effect been?
  May 2011 ,Expert Review of Clinical Pharmacology,Targeting NMDA Receptors for Treatment of Neuropathic Pain,New research may facilitate drug development for neuropathic pain.
  May 2011 ,IRB: Ethics & Human Research,Parents' Understanding and Recall of Informed Consent,How well do people really understand the concept of informed consent in the context of clinical research? This study takes a look.
  May 2011 ,Journal of the National Cancer Institute,Invasive Ipsilateral Breast Tumor Recurrence After Lumpectomy,Breast conserving surgery for DCIS may be more effective when combined with adjuvant therapies.
  April 2011 ,Immunotherapy,Potential Targets for Pancreatic Cancer Immunotherapeutics,Immune-based treatments for cancer represent a rapidly evolving treatment option with great potential.
  May 2011 ,BMC Surgery,Antiplatelet Agents in Surgical Perioperative Management,"For patients on long-term aspirin therapy, do the risks of possible thromboembolic events after withdrawal outweigh the bleeding risks associated with its continuation during the perioperative period?"
  May 2011 ,BMC Surgery,Ultrasound-Guided Breast-Sparing Surgery,Can ultrasound-guided breast-conserving surgery provide better cosmetic outcome--and greater accuracy--in breast cancer patients with palpable tumors?
  April 2011 ,Journal of the American Geriatrics Society,Antidepressant Studies in People With Depression and Dementia,Is a sugar pill sweeter than the real-deal when it comes to benefits from antidepressant trials in patients with dementia?
  April 2011 ,Journal of the National Cancer Institute,Specialty Physician Involvement in Cancer Clinical Trials,Find out what factors are associated with greater physician involvement in cancer-related clinical trials.
  November 2011 ,Current Opinion in Rheumatology,Raynaud's Phenomenon and Digital Ischaemic Complications,The networking of clinicians has facilitated key advances in the management of Raynaud's phenomenon.
  July 2011 ,Expert Review of Anti-Infective Therapy,Better Late Than Never: Antivirals for Dengue,"Despite estimates by the WHO that one third of the earth’s population is at risk of dengue infection, there is currently no approved vaccine or antiviral available."
  October 2011 ,Prostate Cancer and Prostatic Diseases,Managing Metastatic Castration-Resistant Prostate Cancer,"Will new, emerging therapies complement existing treatment options for metastatic castration-resistant prostate cancer?"
  October 2011 ,Future Virology,ARV-based Microbicides and Pre-exposure Prophylaxis for HIV,The promising results of both ARV-based microbicides and oral PrEP have given the HIV prevention field a much-needed boost.
  October 2011 ,International Journal of Clinical Rheumatology,Certolizumab Pegol in Rheumatoid Arthritis,How safe and effective is Certolizumab Pegol for the treatment of Rheumatoid Arthritis?
  October 2011 ,Emerging Infectious Diseases,Global Spread of Carbapenemase-producing Enterobacteriaceae,We believe we are now at the edge of 2 concomitant epidemics of carbapenemase producers worldwide. Is prevention possible?
  October 2011 ,Expert Review of Vaccines,Cellular Adjuvants for Therapeutic Vaccines Against Cancer,Various adjuvant products are currently under evaluation as potential candidates for use in cancer vaccines.
  October 2011 ,Nature Reviews Endocrinology,Thyroid Cancer Stem Cells,Understanding of the cellular origin of thyroid cancer may help identify therapeutic targets.
  October 2011 ,Current Opinion in Allergy and Clinical Immunology,Ocular Surface Damage by Ophthalmic Compounds,A review of the ways to identify and minimize ocular surface damage in patients using chronic eye drop therapies.
  October 2011 ,Journal of the National Cancer Institute,Randomized Phase II Trials: A Long-term Investment,The high rate of failure in phase III trials suggest that current phase II trials are not adequately informative. Can the predictive value of phase II trials be improved by utilizing randomization?
  October 2011 ,Journal of the American Board of Family Medicine,Change in the Clinical Encounter Following Research Participation,What are the short- and long-term effects on clinician and/or patient behavior after participation in a practice-based research network study?
  October 2011 ,Pediatric Critical Care Medicine,FDA Approval for Medications Used in the PICU,Many medications prescribed and administered in pediatric intensive care units may not have FDA approval. What steps should be taken to rectify this problem?
  August 2011 ,Pediatric Pharmacotherapy,Use of IV Ketorolac for Postoperative Analgesia in Infants,Is IV ketorolac safe for postoperative analgesia in infants?
  September 2011 ,Rheumatology,New Drugs Beyond Biologics in Rheumatoid Arthritis,Blocking intracellular signaling cascades is a promising therapeutic target in rheumatoid arthritis.
  September 2011 ,Pharmacotherapy,Revisiting 'Older' Antimicrobials,Some older antibiotics have experienced a 'rebirth' for treatment of multidrug-resistant pathogens.
  August 2011 ,International Journal of Clinical Rheumatology,Diagnosis and Management of Sjögren's Syndrome,Sjorgren's syndrome is a common but difficult-to-treat autoimmune disease. The need to explore new therapies is becoming an important issue to overcome.
  September 2011 ,Journal of the American College of Cardiology,Influence of Global Region on HF Beta-Blocker Trials,"Globalization of clinical trials represents an advance for researchers and patients, but new challenges come with a geographically diverse patient population."
  September 2011 ,Nature Reviews Clinical Oncology,Opportunities and Pitfalls of Cancer Imaging in Clinical Trials,Bruno Morgan discusses advantages and limitations of currently available imaging modalities and highlights the challenges associated with the incorporation of imaging biomarkers into clinical cancer trials.
  August 2011 ,Pharmacotherapy,Cancer Immunotherapy: Sipuleucel-T and Beyond,Will this anticancer vaccine change the future of cancer treatment?
  August 2011 ,American Journal of Pharmaceutical Education,"Projected Pharmacy Education and Research, 2010 to 2015",Will the economy and healthcare reform alter the numbers of future PharmD graduates and pharmacy residents? 
  November 2011 ,Current Opinion in Rheumatology,Clinical Trials in Idiopathic Inflammatory Myopathies,Proper evaluation of treatment in IIM is difficult due to the rare and heterogeneous nature of the disease.
  December 2011 ,Future Microbiology,Bacterial Type I Signal Peptidases As Antibiotic Targets,New antibiotics with novel mechanisms of action are urgently needed to combat the increasing problem of antibiotic resistance. Could type I signal peptidase be an attractive antibiotic target?
  December 2011 ,Nanomedicine,Lipid-based Nanoformulation of Irinotecan,A liposomal delivery system for the antineoplastic drug irinotecan may improve its effectiveness by providing both antivascular as well as antitumor mechanism of activity.
  December 2011 ,Laboratory Medicine,A Lab to Support HIV/AIDS Vaccine and Intervention Trials,This article describes the challenges of creating a sustainable cell processing lab for HIV and AIDS-related clinical trials at a rural field site in Africa.
  December 2011 ,Journal of Pediatric Psychology,An Ethics Case Study of HIV Prevention Research on Facebook,"While social networking sites are a tempting place to implement a research study involving young people, special effort must be made to pay attention to consent, confidentiality, and security."
  November 2011 ,Nanomedicine,Improving Delivery of Nanomedicines to Solid Tumors  ,Effectiveness of nanomedicines in cancer therapy is limited by inadequate delivery and transport. This article looks at the role of apoptosis-inducing tumor priming technology in solving this problem.
  November 2011 ,International Journal of Impotence Research,The Effect of Simvastatin in Penile Erection,Is simvastatin beneficial in the treatment of erectile dysfunction? The STED trial investigates.
  November 2011 ,Personalized Medicine,Drug Approval Challenges in Personalized Treatment,Why is the development of individualized treatment for cancer occurring slowly?
  November 2011 ,Nature Reviews Clinical Oncology,The Silent Minority--Unpublished Data on Cancer Care,"Studies that would have had clinical impact if published promptly are coming out of the closet, but may still have an impact . . ."
  October 2011 ,Expert Review of Anti-Infective Therapy,Will New Antimicrobials Overcome Resistance?,The spread of resistance among Gram-positive and Gram-negative bacteria represents a growing challenge for the development of new antimicrobials.
  November 2011 ,Journal of Pediatric Psychology,Is the Cold Pressor Task Ethically Acceptable in Children?,"The cold pressor task is a commonly used experimental method of inducing pain, but it poses ethical concerns when used with children. How do researchers, children, and parents perceive it?"
  September 2011 ,Nature Reviews Cancer,Tumorigenesis: The Origins of Glioma,Liu and colleagues identify oligodendrocyte precursor cells as the cell of origin for glioma that is caused by inactivating mutations in neurofibromatosis.
  November 2011 ,Journal of the National Cancer Institute,Development of Experimental Drug Combinations for Cancer,"Despite evidence of improved benefit of combined anticancer agents, the majority drugs are developed as single agents, resulting in substantial failure rates."
  September 2011 ,Nature Reviews Cancer,What Does Physics Have to Do With Cancer?,Can the new US National Cancer Institute Physical Sciences-Oncology Centers initiative help us to better understand the complexity of this disease?
  November 2011 ,Europace,Management of Atrial Fibrillation Around the World,"Atrial fibrillation is the same worldwide, but treatments and interpretation of guidelines may vary - depending on where you are."
  October 2011 ,U.S. Pharmacist,New Drug Review 2011,"These drugs are ""new molecular entities"" -- they contain chemical substances marketed for the first time in the US."
  October 2011 ,Nanomedicine,Liposomes As Drug Delivery Systems for the Treatment of TB,Liposome nanocarriers are promising new delivery systems for anti-TB drugs by both intravenous and inhaled routes.
  November 2011 ,Expert Review of Neurotherapeutics,Biologics: The Next-Generation Therapeutics for Analgesia?,"Current therapies for the treatment of chronic pain conditions are inadequate, and there's an urgent need for more effective analgesics. Are biologic agents, such as monoclonal antibodies, the answer?"
  November 2011 ,Rheumatology,Effectiveness of Tocilizumab for Rheumatoid Arthritis,How safe and effective is tocilizumab for rheumatoid arthritis patients?
  February 2012 ,Journal Watch,New Antivirals Show Promise for Hepatitis C Treatment,The findings in this study provide early evidence that the next generation of direct acting antivirals is more potent and effective than currently available agents against hepatitis C infection.
  February 2012 ,Future Microbiology,Microcin C: Biosynthesis and Mechanisms of Resistance,The antibiotic microcin C employs a 'Trojan-horse' strategy to facilitate its transport into a bacterial cell. Can it be manipulated to target specific classes of bacteria?
  February 2012 ,Future Oncology,Effectiveness Research for Prostate Cancer Radiation Therapy,Comparative effectiveness research defines risks and benefits of radiation modalities for prostate cancer.
  February 2012 ,Headache,Clinical Trials 2011: Year in Review,"An overview of multi-center trials of new therapies and novel formulations of previously approved medications for migraine and other common headache disorders, which were conducted in 2011."
  February 2012 ,Diabetes,Brain Sensors in Glucose-stimulated Insulin Secretion,Is this a possible new area of drug development for type 2 diabetes mellitus?
  February 2012 ,Diabetes Care,When is Diabetes Distress Clinically Meaningful?,Read about a diabetes distress scale categorized by biologic and behavioral variables.
  February 2012 ,Expert Review of Dermatology,Immunotherapy for Melanoma,Immunotherapy may be the best weapon against advanced melanoma. This overview of immune therapeutics for melanoma discusses the many promising agents currently in use or under investigation.
  December 2011 ,Annals of Clinical Microbiology and Antimicrobials,Antimutagenic and Antioxidant Effects of Accacia salicina,"The authors examine the potential antioxidant and antimutagenic effects of leaf extracts from Accacia salicina, a species of Acacia tree."
  February 2012 ,Journal Watch,Dexpramipexole in ALS: Cautious Optimism,Might the experimental drug dexpramipexole slow disease progression in ALS? Results of a Phase II trial are promising.
  February 2012 ,Journal of the American Board of Family Medicine,A Randomized Colorectal Cancer Screening Intervention Trial,"This article recounts the challenging and sometimes onerous aspects of conducting a practice-based, randomized colorectal cancer screening intervention trial."
  January 2012 ,Pharmacogenomics,Pharmacogenetics of Drugs Withdrawn From the Market,Advances in pharmacogenomics have elucidated the influence of genetic factors on drug metabolism and efficacy. This review examines how genetics impacted safety issues with several drugs.
  January 2012 ,AIDS,Apparent Declining Efficacy in Randomized HIV Trials,This article discusses the trends in recent HIV clinical trials.
  January 2012 ,Nanomedicine,Mesoporous Silica Nanoparticles in Targeted Cancer Therapy,"This report looks at the therapeutic efficacy and safety of mesoporous silica nanoparticles, inorganic particulates under investigation as a drug delivery mechanism for targeted cancer therapy."
  January 2012 ,Arthritis Research & Therapy,Disturbance of Cytokine Networks in Sjogren's Syndrome,New insights into interconnected cytokines in primary Sjogren's syndrome may lead to new treatments.
  January 2012 ,Rheumatology,Tocilizumab: A Novel Therapy for Large-vessel Vasculitis,Is tocilizumab an effective treatment option for large-vessel vasculitis?
  January 2012 ,Personalized Medicine,Healthcare Payers: Gate or Bridge to Personalized Medicine?,"According to healthcare payers, what are the benefits of pharmacogenomics?"
  January 2012 ,Expert Review of Molecular Diagnostics,Development of Diagnostics for Neuropsychiatric Disorders,Diagnostic advances for neuropsychiatric disorders will best be accomplished through the development of biomarkers--but a better understanding of the underlying molecular mechanisms must come first.
  December 2011 ,Nature Reviews Clinical Oncology,A Personal Note--40 Years After the Cancer Act,"The Cancer Act had a mandate ""to support research and the application of the results of research, to reduce the incidence, morbidity and mortality from cancer."" Has it been effective?"
  November 2011 ,IRB: Ethics & Human Research,When Is It Ethical to Withhold a Research Incentive?,Is it fair for institutional review boards (IRBs) to offer incentives to survey participants? This commentary looks at the issue.
  December 2011 ,Journal of the National Cancer Institute,Company Stock Prices Related to Oncology Drugs,How do public announcements regarding experimental anticancer drugs affect stock prices?
  April 2012 ,Breast Cancer Research,MicroRNA Let-7a Suppresses Breast Cancer Cell Migration ,Learn about the therapeutic potential of let-7a as an antitumor and antimetastatic manager in breast cancer patients.
  April 2012 ,International Journal of Epidemiology,Commentary: The Seven Plagues of Epigenetic Epidemiology,"The authors of this commentary identify seven critical biological, technical and methodological issues that may complicate--and confound--epigenetic study results."
  March 2012 ,Expert Review of Clinical Pharmacology,Drug Development: Lessons From an Undeveloped Drug,What makes a drug successful in the marketplace?
  April 2012 ,International Journal of Clinical Practice,New Therapies for Chronic Hepatitis C Infection,Over 40 new treatment options are undergoing clinical trials for the treatment of hepatitis C virus. Which look to be the most promising?
  April 2012 ,Diabetes,Preventing Beta-Cell Loss and Diabetes With CCBs,Will this research change the future of diabetes therapy?
  February 2012 ,Annals of Clinical Microbiology and Antimicrobials,Antimicrobial Activity of Sida Alba L. (Malvaceae) ,"An overview of the in vitro antimicrobial activity of Sida alba L, an herb in the Malvaceae family used in traditional African medicine. Is it effective against drug-resistant bacterial strains?"
  April 2012 ,Expert Review of Neurotherapeutics,A Novel Treatment for Glioblastoma: Integrin Inhibition,The prognosis for the majority of patients with glioblastoma remains discouraging. This review focuses on the potential of anti-integrin strategies as a promising therapeutic option.
  April 2012 ,Diabetes,Postprandial Intranasal Insulin Intensifies Satiety,Is insulin an effective treatment for food overconsumption?
  April 2012 ,Expert Review of Anti-Infective Therapy,Immunomodulatory Effects of Antimicrobial Agents. Part II,Antiparasitic and antifungal agents have both deleterious and beneficial immunomodulatory properties. What does this mean for treatment?
  April 2012 ,Journal of the American Geriatrics Society,Exclusion of People With Dementia From Geriatrics Research,Are persons with cognitive impairment being excluded from the very clinical research which may help them--without rationale or justification?
  March 2012 ,Expert Review of Anti-Infective Therapy,Immunomodulatory Effects of Antimicrobial Agents. Part I,"What do the past, present, and future hold for antibacterial and antiviral agents?"
  March 2012 ,Future Neurology,Emerging Strategies for the Treatment of Multiple Sclerosis,"An overview of emerging methodologies in the fight against multiple sclerosis, highlighting strategies for prevention through immune modulation, and repair via neuroprotection and remyelination."
  March 2012 ,Journal of the National Cancer Institute,Sipuleucel-T in Castration-resistant Prostate Cancer,The lack of demonstrable tumor responses has prompted calls for scrutiny of the trial design for sipuleucel-T. What are the lessons learned and how will our understanding of related trials for late-stage prostate cancer be improved?
  March 2012 ,Pharmacogenomics,Pharmacogenetics of Antidepressant Drugs,This review summarizes recent progress in isolating biomarkers which might predict which patients will have the greatest benefit from antidepressant therapy for depression and other mood disorders.
  March 2012 ,Pacing and Clinical Electrophysiology,"ICDs, Guidelines, and National Registries",Are we thoroughly mining the ICD device registry data -- to systematically improve outcomes?
  March 2012 ,HIV Medicine,New ART Drugs in Treatment-experienced HIV-infected Patients,What is the efficacy of new ART drugs in treatment-experienced patients?
  March 2012 ,Expert Review of Clinical Pharmacology,Communicating Clinical Trial Results to Study Volunteers,Will improving patient communication improve clinical trial recruitment?
  March 2012 ,Brain,Herbalism Helps Headache,This short commentary highlights some novel therapeutic agents derived from natural sources that may prove to be effective against migraine and other forms of headache.
  March 2012 ,American Journal of Kidney Diseases,New Anemia Therapies: Novel Strategies From Bench to Bedside,What are some of the newer therapies on the horizon for treating anemia of chronic kidney disease? This study looks at some of the options beyond erythropoietin.
  February 2012 ,Arthritis Research & Therapy,Use of Administrative Claims Data for RA Treatment Research,A claims-based algorithm to evaluate the clinical effectiveness of rheumatoid arthritis medications seems promising.
  June 2012 ,AIDS Clinical Care,Efavirenz Better than Nevirapine for Most Patients,"For most patients, efavirenz is preferred over nevirapine, but why?"
  June 2012 ,American Heart Journal,ACE Inhibitors and ARB Blockers for Ischemic Heart Disease,Learn more about the comparative effectiveness of ACE-I/ARB in patients with or at high risk for stable ischemic heart disease.
  May 2012 ,Pediatric Pharmacotherapy,Intranasal Ciclesonide for Allergic Rhinitis in Children,Could the new ciclesonide HFA intranasal spray become a useful tool for allergic rhinitis in children?
  June 2012 ,Arthritis Research & Therapy,Meryl Streep and the Problems of Clinical Trials,Performing clinical trials can get complex. What went wrong in this trial of lupus nephritis patients?
  June 2012 ,Diabetes,Scientific Achievement Award  2011: Defeating Diabesity,What if a drug could treat both diabetes and obesity? You might be surprised at the latest in research and drug development.
  June 2012 ,American Heart Journal,Central Blood Pressure for Guiding Hypertension Management,Will central BP management prove to be feasible -- in terms of patient outcomes?
  June 2012 ,Aging Health,Elderly Women With Heart Failure: Simply Forgotten?,"Elderly women represent a good portion of heart failure patients, and yet they receive little attention compared to men--usually excluded from clinical research, and often under-treated."
  May 2012 ,Arthritis Research & Therapy,"Safety, Pharmacokinetics, and Activity of Pateclizumab",Pateclizumab may provide an attractive alternative therapeutic approach for patients with moderate to severe RA.
  May 2012 ,Future Oncology,Asians vs Caucasians - Lung Cancer and Systemic Therapy,"For lung cancer treatment, find out why ethnicity may make all the difference in the design and conduct of a global clinical study."
  May 2012 ,Current Opinion in Allergy and Clinical Immunology,Vitamin D Supplementation and the Allergy Pandemic,What does a link between vitamin D supplementation and allergy mean for the masses who are vitamin D deficient?
  May 2012 ,Diabetes,A Human Monoclonal Antibody That Improves Glycemic Control,Learn about a new mAb that shows promise for diabetes management.
  May 2012 ,Expert Review of Molecular Diagnostics,Functional Drug-gene Interactions in Lung Cancer,"Utilizing lung cancer as an example, the authors outline the principles that govern drug sensitivity and resistance from a genetic perspective."
  May 2012 ,Future Microbiology,How Mycobacterium Tuberculosis Goes to Sleep,"Ten years ago, the underlying genetic program that allows M. tuberculosis to develop a drug-tolerant dormant form was identified. What have we learned since--and what challenges remain?"
  May 2012 ,Journal of the American College of Cardiology,Personalized Medicine for Devices,The lack of a uniform response to cardiac resynchronization therapy may indicate the need for a more tailored approach -- among patients who meet criteria for biventricular pacing. . .
  April 2012 ,Nanomedicine,"Nanomedicine, Cancer Stem Cells, and Drug Resistance","Cancer stem cells, or tumor-initiating cells, are responsible for resistance, metastasis and relapse of cancers. Can metastatic and cancer stem cells be targeted with nanomedicine-based strategies?"
  April 2012 ,Pediatric Pharmacotherapy,Ivacaftor for Cystic Fibrosis and the G551D-CFTR Mutation,Ivacaftor represents a significant breakthrough for patients with CF.
  April 2012 ,Expert Review of Hematology,Immunotherapy Highlights From American Society of Hematology,"Read about immunotherapy studies presented at the American Society of Hematology annual meeting on such topics as T-cell function, tumor antigen targeting, and more."
  April 2012 ,Future Virology,Introducing Yesterday's Phage Therapy in Today's Medicine,"Could phages, the viruses that kill bacteria, help fight antibiotic-resistant bacteria?"
  April 2012 ,Future Oncology,Systemic Treatment of Malignant Pleural Mesothelioma,Malignant pleural mesothelioma is a rare malignancy with a dismal prognosis. Find out what therapeutic strategies are on the horizon.
  April 2012 ,Journal of the National Cancer Institute,CYP2D6 Genotype in Postmenopausal Women,"In this editorial, 2 breast cancer specialists comment on 2 studies that apparently refute the utility of CYP2D6 as a marker for the benefit of tamoxifen. Why has such a good theory gone wrong?"
  August 2012 ,BMC Urology,Designing the Selenium and Bladder Cancer Trial (SELEBLAT),"The SELEBLAT trial investigates the effect of selenium on the recurrence of bladder cancer, with first results due in 2014."
  July 2012 ,Schizophrenia Bulletin,Psychiatry and the Pharmaceutical Industry,"Is innovation in psychopharmacology at a standstill? In this editorial, the author examines the challenges facing the development of new psychiatric drugs."
  August 2012 ,Neurosurgical Focus,Wisconsin Spine Outcome Study-Pilot,The Wisconsin Spine Outcome Study-Pilot presents a mechanism for establishing comparative effectiveness of currently prevalent treatments for degenerative lumbar disease utilizing a patient registry.
  August 2012 ,Journal of Participatory Medicine,The Impact of Open Access and Social Media on Research,"Two trends, open access and social media, are changing the peer review process. Is research quality being adversely affected?"
  August 2012 ,Neurosurgical Focus,Meta-analysis of Diagnostic Test Accuracy in Neurosurgery,This paper aims to improve neurosurgeons' familiarity with the meta-analysis of diagnostic test accuracy. What are the steps for conducting a systemic review?
  August 2012 ,Journal of the American Board of Family Medicine,Azithromycin for Bronchial Asthma in Adults,How effective is azithromycin in treating chronic asthma in adults?
  August 2012 ,Journal of the National Cancer Institute,The Role of Cancer Research in Noncommunicable Disease,The cancer research community needs to be fully engaged with developments following the UN meeting on noncommunicable diseases. Are you there yet?
  August 2012 ,Diabetes,Steady-State Brain Glucose Levels During Hypoglycemia,Why are patients with T1DM at risk for hypoglycemia?
  August 2012 ,Neurosurgical Focus,Comparative Effectiveness in Neurosurgery: Why It Matters,"Why should a neurosurgeon care about comparative effectiveness? In this article, the author outlines the rationale of comparative effectiveness and illustrates how it applies to neurosurgical topics."
  August 2012 ,Expert Review of Dermatology,Topical Agents and Emerging Perspectives in Psoriasis,"This comprehensive review highlights the most effective topical agents for psoriasis, focusing on promising topical drugs that are currently under investigation."
  July 2012 ,The Annals of Pharmacotherapy,CFTCR-Modifying Medications: The Future of CF Treatment,Read about new targeted agents available for CF.
  July 2012 ,Neurosurgical Focus,An Alternative Approach to Comparative Effectiveness Research,"Are legislative constraints limiting the utility of comparative effectiveness research? This editorial highlights the limitations of the current approach to CER in the US, and proposes an alternative."
  July 2012 ,Emerging Infectious Diseases,Trichomonas Vaginalis Antimicrobial Drug Resistance,"To avoid the emergence of antimicrobial drug resistance, novel treatment options are needed for the treatment of Trichomonas vaginalis."
  July 2012 ,IRB: Ethics & Human Research,Women's Views About Participating in Research While Pregnant,"How can pregnant women be encouraged to participate in clinical research studies? Is it generally safe for them, in most circumstances?"
  August 2012 ,HIV Medicine,The MONET Trial: DRV/r Monotherapy vs. DRV/r Plus Two NRTIs,DRV/r monotherapy or DRV/r plus two NRTIs? Is one treatment plan more effective than the other?
  July 2012 ,Pediatric Pharmacotherapy,New Options for Eradicating Resistant Head Lice,New head lice treatments may be safer and more effective.
  June 2012 ,Personalized Medicine,Genomic Medicine in Atherosclerotic Cardiovascular Disease,Can pharmacogenomics predict who is at risk for MI?
  June 2012 ,Arthritis Research & Therapy,The Future of CCR5 Antagonists in Rheumatoid Arthritis,Are CCR5 inhibitors useful in the treatment of rheumatoid arthritis?
  June 2012 ,Diabetes,Recent Clinical Trials to Preserve B-Cell Function in T1DM,Can pharmacologic interventions delay development of type 1 diabetes? Learn what critical lessons research has taught us.
  May 2012 ,IRB: Ethics & Human Research,Perspectives on Genotype-driven Research Recruitment,What are the specific ethical issues involved in genotype-driven research recruitment?
  October 2012 ,Diabetes Care,Effects of Soy Milk in Diabetic Patients With Nephropathy,Will soy milk improve renal function in patients with diabetic nephropathy?
  September 2012 ,Newborn & Infant Nursing Reviews,Pain Interventions in Premature Infants,What's the best evidence for safe and effective pain management in the NICU?
  October 2012 ,Cardiovascular Diabetology,Low Amylase: Association With Insulin and Insulin Resistance,Is low amylase a cardiometabolic risk factor?
  October 2012 ,BMC Emergency Medicine,Trial: Immediate Total-Body CT Scanning in Trauma Patients,How beneficial is immediate total-body CT scanning in severely injured trauma patients? The REACT-2 trial investigates.
  September 2012 ,IRB: Ethics & Human Research,"Consent for Invasive, Nondiagnostic Research Procedures","How important is it for patients to give informed consent when invasive, nondiagnostic procedures are used in clinical research? This new article explains."
  October 2012 ,Nanomedicine,Nanoparticles as a Drug Delivery System,"Nanotechnology has the potential to revolutionize drug delivery, but challenges remain. This article summarizes recent developments in the use of nanoparticles as drug delivery systems."
  May 2012 ,BMC Musculoskeletal Disorders,"Total Knee Replacement and Physical, Medical Therapy",Is TKA more effective when combined with non-surgical treatments? The MEDIC-study investigates.
  September 2012 ,Expert Review of Clinical Immunology,Current Treatments of Rheumatoid Arthritis,How do rheumatoid arthritis outcomes from Japan differ from those in other nations?
  September 2012 ,Cardiovascular Diabetology,Preventing T2DM: Study Protocol for Educational Intervention,Read about a clinical trial evaluating intensive education for diabetes prevention.
  September 2012 ,Personalized Medicine,Benefit-Risk Management in Personalized Healthcare,Is the healthcare system ready to adapt to pharmacogenomics?
  September 2012 ,Diabetes,Fully Integrated Artificial Pancreas in Type 1 Diabetes,Read about new research designed to modulate insulin delivery in real time.
  September 2012 ,Expert Review of Vaccines,Prostate Cancer Vaccines in Clinical Trials,What is the future for prostate cancer treatment through vaccine immunotherapy?
  May 2012 ,Cardiovascular Diabetology,Ginkgo biloba Reduces Glucose-Induced Endothelial Adhesion,Can this herbal antioxidant reduce the risk of atherosclerosis?
  September 2012 ,American Heart Journal,Under-reporting of Cardiovascular Events in the Rofecoxib Alzheimer Disease Studies,Learn more about avoiding potential drug risks in clinical trials.
  September 2012 ,Future Microbiology,Plant-Derived Antimicrobial Compounds,"With the problem of antibiotic resistance ever-increasing, finding effective alternatives is crucial. Could medicinal plants provide the answer?"
  September 2012 ,Nanomedicine,Crossing the Blood-Brain Barrier: Nanotechnology Strategies,"Nanotechnology may be the key to opening the gate of the blood brain-barrier, providing a significant advantage over currently used drug delivery strategies for brain cancers and other CNS disorders."
  September 2012 ,Diabetes,Intranasal Insulin Suppresses Food Intake,Is intranasal insulin a therapeutic option for weight loss?
  August 2012 ,Future Virology,Eight Common Misconceptions About HIV Vaccines,Are misconceptions about HIV vaccines impeding our progress in controlling the AIDS epidemic?
  August 2012 ,Future Neurology,Generation of Human Neurons and Neural Stem Cells,"Stem cell therapies could have a significant impact on worldwide public health, but techniques for generating neurons and neural stem cells may have risks."
  August 2012 ,Neurosurgical Focus,Comparative Effectiveness Research in Neurotrauma,"Injuries to the nervous system are common and have potentially devastating consequences, yet many challenges exist in determining best management. How can comparative effectiveness be utilized?"
  November 2012 ,Future Oncology,HAMLET: Functional Properties and Therapeutic Potential,This HAMLET is no tragedy but it does kill tumor cells -- with high selectivity.
  November 2012 ,Expert Review of Anti-Infective Therapy,Targeting Antibiotic Resistance in M. tuberculosis,Drug-resistant M. tuberculosis strains pose a serious threat to public health.
  November 2012 ,AccessMedicine from McGraw-Hill,A Promising New Oral Agent for the Treatment of MS,"The first widely used oral agent for MS was approved for use just 2 years ago. This brief review reports on two studies showing that another investigational oral drug, BG-12, is safe and effective."
  November 2012 ,American Heart Journal,Pediatric Cardiovascular Safety,Pediatric drug and device development may use adult data but often requires additional preclinical and clinical testing. Is this enough to protect kids?
  November 2012 ,Expert Review of Hematology,Anti-tumor Immunity After Allogeneic HCT,Find out more about the development of novel post-HCT therapies for patients who are at high risk for disease recurrence following HCT.
  November 2012 ,The British Journal of Dermatology,Which Outcomes Should We Measure in Vitiligo?,"There's little consensus around methods of assessment and outcome measures for vitiligo, making it difficult to compare trial results. What outcomes do patients and clinicians consider important?"
  October 2012 ,The Journal of Invasive Cardiology,Appropriate Timing of Nitroglycerin Prior to IVUS,"Intravascular ultrasound facilitates assessment of coronary plaque severity, but how does nitroglycerine administration timing impact results?"
  October 2012 ,Expert Review of Clinical Immunology,Clinical Trials of Sublingual Immunotherapy,"Most of the experience with sublingual immunotherapy (SLIT) comes from Europe, so is SLIT finally gaining traction in the US?"
  October 2012 ,Nanomedicine,Nanostructuring Molecular Materials for Drug Delivery,Compressed fluid-based technology is a promising novel technique in the preparation of solid micro- and nanoparticles and vesicles as drug delivery systems.
  October 2012 ,Respiratory Research,Effect of Budesonide/Formoterol Maintenance on Severe Asthma,Budesonide/formoterol is used as both maintenance and reliever therapy. How does it stack up to standard therapy for severe asthma?
  October 2012 ,Schizophrenia Bulletin,Twenty-five Years of Glutamate in Schizophrenia,This brief commentary reviews the PCP model of schizophrenia and its relation to NMDA agonists and antagonists. Can these dissociative anesthetics translate into effective clinical treatments?
  October 2012 ,Headache,A Sumatriptan Transdermal System for Acute Migraine,"Migraine is often accompanied by nausea, and oral medications may be difficult to stomach. A transdermal sumatriptan patch, currently undergoing clinical trials, may be the answer."
  September 2012 ,Expert Review of Obstetrics & Gynecology,Histone Deacetylase Inhibitors for Endometriosis,"What are some of the latest drug therapies currently in development for endometriosis, and how promising are epigenetic drugs for the potential treatment of this debilitating gynecologic condition in women?"
  October 2012 ,Spine,Early Initiation of Rehabilitation After Lumbar Spine Fusion,How does early initiation of rehabilitation affect outcomes after lumbar spinal fusion?
  October 2012 ,Diabetes Care,Targets and Tactics for High-Risk Patients With T2DM,What did we learn from trials investigating intensive treatment of hyperglycemia in T2DM?
  October 2012 ,Diabetes,"BNP Modulates Ghrelin, Hunger, and Satiety in Healthy Men",Does this heart failure hormone have anorectic properties?
  October 2012 ,Nanomedicine,Magnetic Nanoparticles for Locally Targeted Therapy,This review examines the use of magnetic nanoparticles for drug delivery which requires penetration of a cellular barrier. What strategies might improve the efficacy of targeting?
  October 2012 ,Pharmacogenomics,Epigenetic-Dependent Regulation of Drug Metabolism,"Gene expression encoding drug transporters and drug-metabolizing enzymes are highly variable between individuals, leading to large variations in drug response. How does epigenetics factor in?"
  August 2012 ,Expert Review of Cardiovascular Therapy,Safety of Inhibition of Cholesteryl Ester Transfer Protein,Learn more about an experimental strategy for increasing HDL-C levels to decrease atherosclerosis.
  October 2012 ,Diabetes,Chronic Exercise Attenuates Lipid-Induced Insulin Resistance,Why does exercise reduce the risk of type 2 diabetes?
  December 2012 ,BMC Urology,IV Lidocaine vs IV Morphine for Renal Colic in the ED,How does IV lidocaine compare with IV morphine in pain reduction of renal colic patients treated in the ED?
  December 2012 ,Current Opinion in Rheumatology,New Treatment Strategies in Large-vessel Vasculitis,Will biologics have a place in the treatment of large-vessel vasculitis?
  December 2012 ,Cardiovascular Diabetology,Postprandial Endothelial Function in Normal Glucose,Research evaluates the relationship between insulin levels and vascular endothelial function.
  December 2012 ,Expert Review of Pharmacoeconomics & Outcomes Research,Demand for Male Contraception,Why aren't pharmaceutical companies developing hormonal contraceptives for men?
  December 2012 ,Expert Review of Vaccines,Chikungunya Virus and Prospects for a Vaccine,There are several vaccine candidates in preclinical and clinical development for the Chikungunya virus.
  December 2012 ,Annals of Clinical Microbiology and Antimicrobials,Antibacterial Activity of Plasma From Crocodile,Alligators and crocodiles are remarkably resistant to microbial infection. Might they be a source of a novel naturally occurring antibacterial agent?
  December 2012 ,Personalized Medicine,Personalizing Rare Disease Research,How will exome sequencing improve diagnosis of rare diseases?
  December 2012 ,American Heart Journal,Erythropoietin Treatment in Patients With AMI,Is there a relevant role for erythropoietin in treating patients with myocardial infarction?
  December 2012 ,Seminars in Neurology,ALS: Drug Therapy From the Bench to the Bedside,"The pathophysiology of ALS remains poorly understood, and only one drug has been shown to enhance survival. This article reviews hypotheses regarding the genesis of ALS and potential new therapies."
  December 2012 ,Expert Review of Anti-Infective Therapy,Targeting Drug Tolerance in Mycobacteria,Is biofilm formation a survival strategy of M. tuberculosis in chronic TB infection?
  October 2012 ,Nanomedicine,Nanodelivery Strategies in Cancer Chemotherapy,"Drug delivery continues to be a stumbling block in safe and efficacious cancer chemotherapy, but revolutionary developments in nanotechnology are paving the way for better delivery systems."
  December 2012 ,International Journal of Impotence Research,Losartan Improves Erectile Dysfunction in Diabetic Patients,Is losartan alone effective in treating erectile dysfunction in diabetics -- or is combination therapy with tadalafil more beneficial?
  December 2012 ,Annals of Clinical Microbiology and Antimicrobials,In Vitro Antimicrobial Activity of Cryptolepis sanguinolenta,"Cryptolepis sanguinolenta, a plant mostly found in the tropical rain forest regions of Africa, demonstrated significant antimicrobial activity in this study."
  December 2012 ,Expert Review of Vaccines,A Therapeutic Vaccine for Human Chagas Disease,Heart disease caused by Chagas disease could be prevented or significantly delayed with the Chagas vaccine.
  November 2012 ,Arthritis Research & Therapy,B Lymphocyte-Typing for Predicting Response to Rituximab,Can B lymphocte-typing identify non-responders to rituximab ahead of time?
  November 2012 ,BMC Neurology,Masitinib Treatment in Patients With Progressive MS,"Treatment options for patients suffering from progressive forms of multiple sclerosis are few. Masitinib, an oral tyrosine kinase inhibitor, showed promise in this exploratory trial."
  November 2012 ,BMC Musculoskeletal Disorders,Use of a Minimalist Footwear vs Habitual Shoe in Knee OA,Long-term use of minimalist shoes may be an effective and inexpensive treatment option for knee OA.
  November 2012 ,American Heart Journal,Cardiovascular Outcomes in BARI 2 Diabetes Trial,What are the risks associated with an abnormal ankle-brachial index in patients with type 2 diabetes and stable coronary artery disease?
  November 2012 ,Expert Review of Clinical Pharmacology,Novel Therapeutics for Gastroesophageal Reflux Symptoms,Up to 30% of patients with GERD have inadequate relief with PPIs. Are new and better drugs in development?
  November 2012 ,Skin Therapy Letter,Device-Based Therapies for Onychomycosis Treatment,"Device-based therapies such as lasers, photodynamic therapy, iontophoresis, and ultrasound are promising solutions for the treatment of onychomycosis."
  February 2013 ,Immunotherapy,Immune Modulators as Adjuncts in Invasive Fungal Infections,"Antifungal immunotherapy now includes age-old interventions as well as promising experimental techniques, but transition from the bench to clinical-phase studies just isn't keeping pace. . ."
  October 2012 ,Interventional Cardiology,"CAS, CREST and AHA Guidelines for Treating Carotid Stenosis",Just how equivalent are carotid artery stenting and carotid enderterectomy?
  February 2013 ,Future Virology,Development of SARS Vaccines and Therapeutics Still Needed,The development of vaccines and therapeutics for the prevention and treatment of SARS is still an urgent issue that needs to be addressed.
  February 2013 ,Nanomedicine,EGF Receptor-Targeted Nanocarriers for Cancer Treatment,The utilization of EGF receptor targeting to enhance delivery of chemotherapeutic and diagnostic agents to EGFR-overexpressing cancers is a novel and promising strategy in nanomedicine.
  February 2013 ,Annals of Oncology,Ipilimumab in Combination With Paclitaxel and Carboplatin in SCLC,This study enrolled patients with ED-SCLC as well as those with advanced NSCLC. Results for the ED-SCLC cohort are presented here.
  February 2013 ,Future Microbiology,Developing Oral Probiotics From Streptococcus salivarius,"S. salivarius, the principal bacterium colonizing the oral cavity, shows promise as a probiotic for control of a variety of infections, from halitosis and dental caries to otitis media and candida."
  January 2013 ,Expert Review of Clinical Pharmacology,Modeling Schizophrenia: Uncovering Novel Therapeutic Targets,Learn about animal modeling strategies being used to discover novel therapies for schizophrenia.
  January 2013 ,Malaria Journal,New Medicines for the Control and Elimination of Malaria,What is on the horizon for new therapies in the treatment of malaria?
  January 2013 ,Pharmacogenomics,Improving Clinical Trial Sampling for Future Research,"Challenges and recommendations for collecting adequate, representative samples for pharmacogenomic and future research in global trials are identified by the Drug Information Association."
  January 2013 ,The Journal of Invasive Cardiology,The RESPECT Trial,"What are the pros and cons of patent foramen ovale closure, when compared to medical management?"
  January 2013 ,Diabetes,Role for DPP4 in Obesity-Induced Visceral Inflammation,Does DPP-4 regulate adipose inflammation in obesity?
  January 2013 ,BMC Endocrine Disorders,Effect of Eplerenone on Parathyroid Hormone Levels in Patients With Primary Hyperparathyroidism,Can this mineralocorticoid receptor antagonist reduce PTH secretion?
  January 2013 ,Critical Care,7-day Doripenem vs 10-day Imipenem-Cilastatin for VAP,Which VAP treatment course has better outcomes? The results might surprise you.
  January 2013 ,Health and Quality of Life Outcomes,The Anti-Clot Treatment Scale (ACTS) in Clinical Trials,"This study evaluated the reliability and validity of the Anti-Clot Treatment Scale, a patient-reported instrument to assess satisfaction with anticoagulant treatment for venous thromboembolism."
  January 2013 ,Diabetes,Levels of Fetuin-A and Hepatic Enzymes and Risk of T2DM,Is this glycoprotein associated with diabetes risk?
  January 2013 ,BMC Musculoskeletal Disorders,Return to Work in Sick-Listed Employees With Low-Back Pain,Is there a difference in sick leave relapse in those receiving brief vs multidisciplinary intervention for low-back pain?
  January 2013 ,Journal of Pediatric Psychology,Ethical Guidance for Pediatric e-health Research,"E-health research is a fast-growing research tool in pediatric psychology, but there is little pragmatic guidance as to ethical best practice. This article aims to provide ethical guidelines."
  January 2013 ,Clinical Endocrinology,Diet Habits and Their Relationship With Metabolism in PCOS,How are hormone levels affected by diet in patients with PCOS?
  January 2013 ,BMC Endocrine Disorders,Association of ALT With the Hepatic Insulin Resistance Index,Can ALT be used to evaluate hepatic insulin resistance?
  December 2012 ,Personalized Medicine,Why Personalized Medicine Will Fail If We Stay the Course,Is research in individualized medicine taking all ethnicities into consideration?
  April 2013 ,BMC Family Practice,Family Physicians' Diagnostic Gut Feelings Are Measurable,Can 'gut feeling' in diagnostic reasoning be measured by means of a questionnaire?
  April 2013 ,Journal of the American College of Cardiology,CardioMEMS Champion Heart Failure Monitoring System,Find out why the FDA is taking a cautious approach with a new therapy that could help patients with heart failure to stay in tune.
  April 2013 ,The Annals of Pharmacotherapy,Use of Number Needed to Treat in Cost-Effectiveness Analyses,Values like number needed to treat and number needed to harm are easily understood. Should health care economic studies use more of such measures?
  April 2013 ,Rheumatology,"Osteoclast Migration, Differentiation and Function",How will osteoclast-targeted therapies impact future treatment of RA?
  April 2013 ,Expert Review of Neurotherapeutics,Individual Treatment Response in ADHD,Key to addressing the treatment needs of patients with ADHD is the development of psychometrically validated instruments to measure treatment response.
  April 2013 ,Journal of the National Cancer Institute,Radiotherapy Protocol Deviations and Clinical Outcomes,How do radiotherapy protocol deviations in clinical trials affect treatment failure and overall mortality?
  April 2013 ,The Annals of Pharmacotherapy,Protocol Design on Outcomes in RA Treated With Rituximab,Does rituximab produce sustained remissions in RA?
  March 2013 ,Expert Review of Clinical Pharmacology,Polypharmacology: Drug Discovery for the Future,Drug molecules may interact with many targets causing adverse effects. How is drug design reducing this risk?
  March 2013 ,Future Neurology,Peptidergic Drugs for Treatment of Traumatic Brain Injury,"Cerebrolysin, a peptidergic drug with neuroprotective and neurorestorative properties, presents a novel, multimodal approach to the treatment of traumatic brain injury."
  March 2013 ,Malaria Journal,Pyronaridine-artesunate Granules for Pediatric Malaria,Are pyronaridine-artesunate granules an effective treatment option for children with P. falciparum malaria?
  March 2013 ,Current Opinion in Neurology,Promoting Neuroplasticity and Recovery After Stroke,What do we know about recovery after stroke? This review poses a theoretical framework for new interventions for poststroke rehabilitation in light of current knowledge of neuroplasticity.
  March 2013 ,Nanomedicine,Biotargeted Nanomedicines for Cancer,This commentary highlights six critical tenets which will facilitate the successful development of biotargeted nanomedicines for cancer.
  March 2013 ,Nutrition and Metabolism,Dietary Protein in Weight Management,"The authors propose two theories, 'protein spread theory' and 'protein change theory' in an effort to explain discrepancies in clinical studies regarding the effect of protein intake on body weight."
  March 2013 ,Pharmacogenomics,Pharmacogenomics: A Bridge to Individualized Cancer Therapy,Pharmacogenomics has the potential to revolutionize anticancer drug development by reducing life-threatening toxicity and improving therapeutic efficacy. This review explores the latest research.
  March 2013 ,Respiratory Research,Airway Responses and Inflammation in Subjects With Asthma,How does a rapid-fire approach to bronchial allergen challenges impact research subjects with asthma? What's the clinical message?
  February 2013 ,AccessMedicine from McGraw-Hill,Endovascular Treatment Following IV tPA in Acute Stroke,Find out why this trial was halted.
  February 2013 ,Future Microbiology,Emergence of Drug-Resistant and Untreatable Gonorrhea,Treatment options for gonorrhea are diminishing rapidly due to antimicrobial resistance. Is an era of untreatable gonorrhea approaching?
  February 2013 ,Expert Review of Anti-Infective Therapy,Microbicides for the Prevention of Sexually Transmitted HIV,Can microbicide development aid in the prevention of HIV transmission?
  February 2013 ,Clinical Endocrinology,Treatment of Hypovitaminosis D With Cholecalciferol,Does oral vitamin D3 work just as well as intramuscular vitamin D3?
  February 2013 ,Critical Care,RCCT of Atorvastatin in Reducing the Severity of Sepsis,Do statin naive patients with sepsis have lower severity of illness with a daily dose of atorvastatin?
  July 2013 ,Nanomedicine,Nanoparticles and the Coagulation System: Safety Concerns,"The use of nanoparticles to carry pro- or anticoagulant factors is a promising new area, but may lead to undesirable side effects. How can these be ameliorated?"
  June 2013 ,Malaria Journal,"Artesunate-Mefloquine, Partnerships in Drug Development",A safe and efficacious fixed dose combination treatment is now available to treat malaria patients in resource-poor settings.
  June 2013 ,Expert Review of Clinical Immunology,Targeting IL-15 in Large Granular Lymphocyte Leukemia,"Waldmann, a pioneer in cytokine biology, reports the first-in-human Phase I trial of Hu-Mikb1."
  June 2013 ,Health and Quality of Life Outcomes,Patient-Reported Outcomes With Apremilast for Psoriasis,Apremilast is an investigational drug in clinical trials for treatment of moderate to severe psoriasis. What is its effect on patient-reported outcomes?
  June 2013 ,Expert Review of Cardiovascular Therapy,Impact of ACE Inhibition on Mortality in Hypertension Trials,Don't keep an 'ACE in the hole'. Use it first. Find out why.
  June 2013 ,Respiratory Research,Clinical Use of Exhaled VOCs in Pulmonary Diseases,"Are there different 'breath-prints' for asthma, lung cancer, COPD, and cystic fibrosis?"
  June 2013 ,International Journal of Clinical Practice,Differing Preparations of Glucosamine for Osteoarthritis,"Research into the efficacy of glucosamine for osteoarthritis has proved inconclusive, with varying results. Could different preparations of glucosamine be a cause of inconsistencies among trials?"
  June 2013 ,IRB: Ethics & Human Research,Children Enrolled in Parents' Research,Is it ethical for children to be involved in their parents' research studies? This new article takes a close look at the issues.
  June 2013 ,Journal of Viral Hepatitis,Virus-Neutralizing Antibodies to Hepatitis C Virus,Will new research in the adaptive immune response help scientists develop a vaccine against hepatitis C?
  June 2013 ,BMC Pregnancy and Childbirth,Managing Reduced Fetal Movements After 36 Weeks Gestation,Is a randomised controlled trial of the management of reduced fetal movement feasible in women after 36 weeks gestation?
  June 2013 ,Nanomedicine,Nanoparticles and the Blood Coagulation System. Part I,How can nanotechnology be used in the treatment of coagulation disorders? This article reviews recent advances in the understanding of nanoparticle interactions with plasma coagulation factors.
  June 2013 ,Current Opinion in Ophthalmology,Glaucoma Therapy and Ocular Surface Disease,What is the most effective way for clinicians to treat glaucoma in patients with ocular surface disease?
  June 2013 ,Annals of Clinical Microbiology and Antimicrobials,In vitro Antimicrobial Activity of Artemisia parviflora,"Do extracts of Artemisia parviflora, a plant belonging to the Aster family,  have antimicrobial and antioxidant properties?"
  May 2013 ,European Heart Journal,Clinical Implications of JUPITER in a Contemporary Population,JUPITER-eligible individuals can't seem to escape the force-field of earthly cardiovascular risks the way cohorts with lower c-reactive protein levels do. Why?
  May 2013 ,AccessMedicine from McGraw-Hill,Mipomersen in Homozygous Familial Hypercholesterolemia,"This brief review covers the antisense oligonucleotide mipomersen, an orphan drug and a first-in-class drug for treatment of homozygous familial hypercholesterolemia."
  May 2013 ,Brain,Human Prion Diseases,"Therapeutic trials in patients with Creutzfeldt-Jakob disease have been limited, but recent progress in our understanding of prion diseases and new diagnostic techniques opens up new opportunities."
  May 2013 ,Nutrition and Metabolism,Biological and Therapeutic Effects of Ortho-Silicic Acid,"Silicon in its bioavailable form of ortho-silicic acid may prove to have potential therapeutic effects for a wide variety of conditions, from Alzheimer's disease to osteoporosis."
  May 2013 ,Rheumatology,Targeting Monocytes/Macrophages in the Treatment of RA,Is targeting monocytes/macrophages an effective strategy for treating RA and other autoimmune diseases?
  May 2013 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Emergency Physician Turnover and Clinical Trial Planning,How frequent is emergency physician turnover -- and can it negatively impact researchers designing clinical trials?
  May 2013 ,American Heart Journal,Evaluation of Drug Effects on Cardiac Conduction,Get current expert opinions on EKG-based safety measurements and how they're affected by different drugs.
  September 2013 ,European Heart Journal,Mens Sana In Corpore Sano Revisited,This editorial ponders the credibility of acetylcholinesterase inhibitors as dual action agents for cardiovascular health and cognitive function.
  September 2013 ,BMC Musculoskeletal Disorders,Medical Record Abstraction for Orthopedic Research,Can researchers with no medical training reliably abstract medical record information for clinical research?
  September 2013 ,AccessMedicine from McGraw-Hill,Riociguat for Thromboembolic Pulmonary Hypertension,Riociguat is the first drug to demonstrate improved hemodynamics and function in patients with chronic thromboembolic pulmonary hypertension.
  September 2013 ,Malaria Journal,Open Access Data Online to Advance Malaria Research,"As an aim to advance malaria research, accessible and usable malaria data can now be found online.  "
  August 2013 ,Pediatric Pharmacotherapy,Therapies for Pulmonary Arterial Hypertension in Children,"This article reviews several recent PAH studies, as well as new therapies for the treatment of PAH in children."
  August 2013 ,Expert Review of Endocrinology and Metabolism,Trying to Make a Difference for Those With Type 1 Diabetes,"Mark A. Atkinson, an international leader in type 1 diabetes research, shares his experiences and thoughts about this 'terrible' disease."
  August 2013 ,International Journal of Clinical Rheumatology,Therapeutic Targeting of T Cells in Systemic Sclerosis,What is the role of T cells in systemic sclerosis?  Will targeting T cells be an effective treatment solution?
  August 2013 ,Future Microbiology,Biofilm-Associated Infections: Novel Therapeutic Strategies,This review focuses on recent progress in understanding the mechanisms of biofilm-specific antimicrobial resistance. What innovative anti-biofilm agents are in the pipeline?
  August 2013 ,Annals of Clinical Microbiology and Antimicrobials,Antibacterial Activity of a Pseudomonas Strain Against MRSA,This study investigated the potential antibacterial activity of an extracellular compound derived from Pseudomonas aeruginosa. Could it be effective against MRSA?
  August 2013 ,Current Opinion in Infectious Diseases,Treatment and Control of Scabies,What options are available for the treatment of scabies?
  August 2013 ,Rheumatology,Small Molecules Targeting JAKs in the Treatment of RA,"Find out more about tofacitinib, which is now the first-in-class compound on the market in the USA for the treatment of RA."
  July 2013 ,Nanomedicine,Nanotechnological Strategies for Targeting Tumor Vasculature,Tumor vasculature presents an intriguing therapeutic target in a variety of cancers. How might nanotechnology provide strategies for future vascular-targeted therapy?
  July 2013 ,AIDS,Dolutegravir in Antiretroviral-naive Adults With HIV-1,"Dolutegravir (DTG) is a newer, potent INI. How effective and tolerable is it in treatment-naïve HIV patients?"
  July 2013 ,Annals of Oncology,Attitudes of Patients With Metastatic Breast Cancer Toward Research Biopsies,Do patients with metastatic breast cancer mind when we 'needle' them -- for the benefit of advancing research?
  July 2013 ,Future Microbiology,Phage Cocktails and the Future of Phage Therapy,Could 'cocktails' of bacteriophages -- viruses with an ability to infect and kill bacterial cells -- be an effective weapon against antibiotic-resistant bacterial infections?
  July 2013 ,BMC Neurology,Biomarkers for Disease Progression in Parkinson's Disease,Do any reliable biomarkers for disease progression in Parkinson's disease currently exist? What characteristics should such a biomarker have?
  July 2013 ,Pediatric Pharmacotherapy,Alternative Forms of Oral Drug Delivery for Pediatrics,"Crushing, cutting, and emptying capsules can stop. Innovations in drug delivery technology are leading to new oral alternatives better suited to the pediatric population."
  July 2013 ,Rheumatology,Novel Small Molecule Therapeutics in Rheumatoid Arthritis,"Novel therapies are being developed in autoimmune diseases, particularly RA."
  July 2013 ,Pharmacogenomics,Personalized Medicine in Oncology,"Despite its promise, actual implementation of personalized medicine into oncology remains limited. What issues still need to be addressed before it can be fully integrated into clinical practice?"
  July 2013 ,Current Opinion in Rheumatology,Treatment of Spondyloarthropathy,What new therapies are on the horizon for  the treatment of spondyloarthropathy?
  December 2013 ,Immunotherapy,Immunotherapy for Pulmonary TB,"With the continuous increasing epidemic of multidrug-resistant TB, new drugs and vaccines are urgently needed."
  December 2013 ,Expert Review of Vaccines,Repositioning Therapeutic Cancer Vaccines,The experience with cancer vaccines in the past has been less than rewarding but has provided critical knowledge to help move immunotherapy in cancer forward.
  December 2013 ,Diabetes,DCCT and EDIC at 30 Years: Advances and Contributions,Read how these trials have improved type 1 diabetes therapy and resulting outcomes in your patients.
  December 2013 ,The British Journal of Dermatology,Interpreting Trials of Biologic Treatments for Psoriasis,How can one properly evaluate the many long-term studies of biologic treatments for psoriasis? This review provides tips on how to compare trial design and effectively analyze data.
  December 2013 ,Skin Therapy Letter,Emerging Therapeutic Options in the Treatment of Psoriasis,"This review looks at several therapeutic classes of small molecules, both oral and topical, which are proving to be promising treatment options in psoriasis."
  December 2013 ,Expert Review of Vaccines,Mobilizing and Evaluating Anticancer T Cells,What are the pitfalls and solutions for mobilizing and evaluating T cells in immunotherapy?
  August 2013 ,Annals of Clinical Microbiology and Antimicrobials,New Antibiotics for Bad Bugs: Where Are We?,"Only one new antibiotic has been approved by the FDA since 2010, and few are in the pipeline -- yet new antibiotics are urgently needed. What's the current status of antibiotic development?"
  November 2013 ,Current Opinion in Neurology,Pharmacological Prospects for Duchenne Muscular Dystrophy,Recent months have seen exciting developments regarding novel therapeutic agents for Duchenne muscular dystrophy. Where do we stand in finding an effective treatment?
  November 2013 ,American Heart Journal,Shaping the Future of Acute Heart Failure Trials,Will a boost in heart failure research methods translate to better patient outcomes?
  November 2013 ,Laboratory Investigation,Autophagy in EGFR-Independent EGFR-Mutant Lung Cancer,Could autophagy inhibitors alone or in combination with tyrosine kinase inhibitors be an effective approach for the treatment of EGFR-mutant lung cancers?
  October 2013 ,The Hospitalist,Back to the Future,"This article profiles the winners of the Society of Hospital Medicine's annual Research, Innovations, and Clinical Vignettes scientific abstract and poster competition."
  October 2013 ,Brain,Microtubule-Based Treatment of Disease the Nervous System,"In this review, the authors investigate the potential of microtubules as therapeutic targets for nerve injury, neurodegenerative diseases, and cancer of the nervous system."
  October 2013 ,BMC Musculoskeletal Disorders,Disability and HRQoL in Patients Undergoing Spinal Fusion,How does spinal fusion surgery affect disability and health-related quality of life?
  September 2013 ,Expert Review of Neurotherapeutics,Targeting the Trigeminocervical Complex in Migraine,This review explores the hypothesis that dysfunction of neural mechanisms that mediate trigeminovascular activation are at the root of migraine. Could this be a fruitful target for drug development?
  October 2013 ,Future Neurology,Neuronal Adhesion and Synapse Organization After TBI,"In this article, the authors focus on the cellular and synaptic alterations that occur with traumatic brain injury. Could synaptic cell adhesion molecules be potential targets for future therapeutics?"
  October 2013 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Using Electronic Surveys in Violence Research,"The sender of electronic surveys for violence research may influence response rates, a new study suggests."
  October 2013 ,IRB: Ethics & Human Research,Research Participants' Expectations,Do people who are recruited for clinical research studies generally understand what  they're participating in? This new article explores the issues.
  October 2013 ,BMC Pulmonary Medicine,Psychometrics of CAMPHOR and SF-36 in Pulmonary Hypertension,Which tool should you choose for patients with pulmonary hypertension?
  October 2013 ,Laboratory Investigation,"Patient-Derived Xenografts, the Cancer Stem Cell Paradigm, and Cancer Pathobiology in the 21st Century",Do we need a change in our basic approach to cancer pathobiology? This review calls for a new model of collaborative cancer research based on the cancer stem-cell paradigm.
  October 2013 ,Personalized Medicine,Disclosure of Incidental Genomic Findings Involving Children,What are the consequences of disclosing genomic findings to children and their parents?
  January 2014 ,AIDS,Highlights on HIV Eradication in 2013,"Almost 20 years after the introduction of HAART, we are still struggling to find a way to eradicate HIV. Is a cure for HIV infection achievable?"
  January 2014 ,Alimentary Pharmacology & Therapeutics,Vitamin D and Inflammatory Bowel Diseases,"Are patients with a vitamin D deficiency at an increased risk for developing IBD, and does it also contribute to more severe disease? This new study examines the connection."
  January 2014 ,The Pediatric Infectious Disease Journal,Effect of PCV Dosing Schedules on Prevention of Pneumonia,What is the optimum PCV dosing schedule for the prevention of pneumonia in children?
  January 2014 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Maraviroc in HIV Patients: 5-Year Safety Data,Maraviroc is an approved antiretroviral drug with a unique mechanism of action. How safe is this therapy in treatment-experienced HIV+ patients?
  January 2014 ,Current Opinion in Gastroenterology,Treatment of Ulcerative Colitis,"Since some medications, such as anti-TNF agents, work better than others in ulcerative colitis, how can clinicians best tailor treatments for their patients?"
  January 2014 ,Current Orthopaedic Practice,Lumbar Disc Replacements and Motion Preservation Devices,What do we currently know about lumbar disc replacement and motion preservation devices?
  January 2014 ,International Journal of Clinical Practice,Vortioxetine for Major Depressive Disorder,Vortioxetine is a recently approved antidepressant with a unique mechanism of action. This review summarizes available data regarding the efficacy and safety of vortioxetine for the treatment of MDD.
  January 2014 ,HIV Medicine,CD4:CD8 Ratio and Markers of Age-Associated Disease in HIV,A low CD4:CD8 ratio despite at least 1 year of effective ART may be a marker of conditions associated with age-related disease.
  January 2014 ,The Nation's Health,"As Hispanics Lag in Clinical Trials, Researchers Take Action","While there are a disproportionately high number of Hispanics living with chronic conditions in the US, many are not entering clinical trials. How can public health clinicians reach out and encourage them to partake?"
  January 2014 ,Alimentary Pharmacology & Therapeutics,Comparative Effectiveness of HCV Protease Inhibitors,"This study examines the effectiveness of the 2 protease inhibitors, boceprevir and telaprevir. Is 1 preferred over the other?"
  January 2014 ,Medicine and Science in Sports and Exercise,Artifacts in Plasma Volume Changes due to AHA-Derived HCT,How do changes in plasma osmolality affect the measurement of hematocrit?
  January 2014 ,Menopause,Acupuncture and Herbs for Hot Flushes in Postmenopausal Women,What does the latest research tell us about the effectiveness of both acupuncture and Chinese herbs in the management of hot flushes in postmenopausal women?
  January 2014 ,Annals of Clinical Microbiology and Antimicrobials,Antibacterial Activity of Nymphaea nouchali (Burm. f) Flower,Does the water lily flower Nymphaea nouchali have potential as a candidate for development of a novel broad spectrum antibacterial?
  January 2014 ,Critical Care Medicine,Potentially Preventable Hospital Exposures and ARDS,Find out what specific hospital exposures impact the rate of acute respiratory distress syndrome development among at-risk patients.
  January 2014 ,Journal of Medical Case Reports,CARE Guidelines for the Standardization of Case Reports,"This editorial serves as a brief introduction to the newly published CARE (CAse REport) guidelines, which aim to serve as a framework for the standardization of case reporting."
  January 2014 ,Medicine and Science in Sports and Exercise,Exercise Training in Abdominal Aortic Aneurysm Disease,Learn more on the potential role exercise therapy can play in managing patients with early abdominal aortic aneurysm disease.
  January 2014 ,Alimentary Pharmacology & Therapeutics,NASH: A Case for Personalized Treatment,"As clinicians begin to better understand the pathophysiology of NASH, what future treatment strategies lie ahead for them to manage the disease in their patients?"
  January 2014 ,Current Opinion in Allergy and Clinical Immunology,Sublingual Immunotherapy in Clinical Trials and Real Life,"Sublingual immunotherapy is effective in allergic rhinitis and asthma, but apart from its efficacy, safety is crucial since it's usually self-administered. . ."
  January 2014 ,Nanomedicine,Strategies for Improving Mucosal Drug Delivery,"Transmucosal drug delivery is a promising approach, as it is easy to administer, nonpainful, and enhances patient compliance. What recent progress has been made in drug delivery for mucosal surfaces?"
  January 2014 ,International Journal of Clinical Practice,Vortioxetine for Treatment of Generalised Anxiety Disorder,Is the newly approved novel antidepressant vortioxetine useful in the treatment of generalized anxiety disorder?
  February 2014 ,Future Oncology,Metabolism and Transport of Tamoxifen,Learn more about the association between CYP2D6 inhibition and tamoxifen effectiveness.
  February 2014 ,The Pediatric Infectious Disease Journal,Effect of PCV Dosing Schedules on Pneumococcal Disease,How much effect do PCV dosing schedules have on pneumococcal disease in infants?
  February 2014 ,AIDS,Non-AIDS-Related Mortality Among HIV-Infected Individuals,This study compares non-AIDS related mortality of HIV+ individuals who started HAART at different CD4 levels with mortality of individuals not infected with HIV.
  February 2014 ,Journal of Perinatology : Official Journal of the California Perinatal Association,Work of Breathing in Infants With Respiratory Insufficiency,This study compares infants' work of breathing while receiving different settings of nasal CPAP and high flow oxygen via nasal cannula.
  February 2014 ,Current Opinion in Allergy and Clinical Immunology,Single vs Multiple Antigens in Allergic Rhinitis Immunotherapy,Controversial aspects of single vs multiallergen allergen immunotherapy are reviewed.
  February 2014 ,Clinical Endocrinology,TRAIL Concentration and Diabetic Therapy,Is this protective marker of endothelial function increased after initiation of antidiabetes agents?
  January 2014 ,Current Opinion in Pulmonary Medicine,An Update on Allergen Immunotherapy and Asthma,Learn more about the effect of allergen-specific immunotherapy on asthma.
  January 2014 ,Morbidity & Mortality Weekly Report,Evidence-Based Injury Prevention,How can public health clinicians work together to educate the public about the ways in which to prevent injuries of all types? This new report looks at strategies.
  January 2014 ,American Heart Journal,Trends Among Older Patients With Non-STEMI,Learn about evidence-based therapy use and short- and long-term mortality over time among older patients with non-STEMI.
  January 2014 ,Europace,Atrial Fibrillation Management After 2010 ESC AF Guidelines,Did the management of AF patients in 2012 adapt to guideline recommendations or go rogue?
  January 2014 ,Journal of Gastroenterology and Hepatology,Effect of Probiotics on Irritable Bowel Syndrome,Do probiotics help IBS patients with the management of the various symptoms associated with the disease?
  January 2014 ,Alimentary Pharmacology & Therapeutics,Managing Chronic HCV in Patients Unable to Take Antivirals,"Besides standard treatments, such as interferon-based antiviral therapy, what are some of the other treatment strategies that can be employed to manage chronic hepatitis C?"
  January 2014 ,Journal of Viral Hepatitis,"HCV and Lipid Metabolism, Hepatic Steatosis, and NAFLD",Is there a role for lipid lowering therapy in combination with PEG/RBV in the treatment of hepatitis C and other liver diseases?
  January 2014 ,Infection Control and Hospital Epidemiology,Mortality of MRSA USA300 vs. Non-USA300 Invasive Infections,Are MRSA USA300 infections associated with higher mortality than non-USA300 invasive infections?
  January 2014 ,Menopause,Effects of Low-fat Diet on Serum Lipids in Women,What effect does a low-fat diet have on lipids in both premenopausal and postmenopausal women? This new study looks at the numbers.
  January 2014 ,Journal of Cardiovascular Electrophysiology,Cryoballoon vs RF Ablation in Paroxysmal Atrial Fibrillation,Which ablation method has the best acute success and lowest overall complication rate for treating paroxysmal atrial fibrillation?
  January 2014 ,BMC Musculoskeletal Disorders,Characteristics for Describing Patients With Knee OA,A survey of clinical experts identifies the baseline characteristics to appropriately describe patients with knee OA.
  January 2014 ,Nanomedicine,Shaping Cancer Nanomedicine: The Effect of Particle Shape,How does a nanoparticle's shape affect its rate of tumor penetration and therapeutic efficacy in cancer drug delivery?
  January 2014 ,Future Neurology,Optimizing Mouse Models of Neurodegenerative Disorders,"This review takes a look at the history of model development for neurodegenerative diseases. What has been learned which may improve the design, development and use of mouse models?"
  January 2014 ,Clinical Endocrinology,Level of Glycemic Control and Associated Factors in T2DM,Hit or miss? Are patients achieving goals for type 2 diabetes treatment?
  February 2014 ,The British Journal of Dermatology,Radiotherapy for Lentigo Maligna,The authors present recommendations for radiotherapy of lentigo maligna based on their experience from a multidisciplinary lentigo maligna clinic.
  February 2014 ,Menopause,Women's Health Initiative Clinical Trials,Could calcium and vitamin D supplementation help to prevent fractures in women who are already on hormone therapy? This new study investigates.
  February 2014 ,American Journal of Transplantation,Costs Among Patients Awaiting Liver Transplantation,What's the economic burden of liver disease -- in the pre-transplant phase?
  February 2014 ,HIV Medicine,HIV Guidelines and Treatment Outcomes,How closely do physicians adhere to national guidelines for HIV treatment and how does this affect patient outcomes?
  February 2014 ,American Heart Journal,Absolute Survival After CRT According to Baseline QRS,Does baseline QRS duration relate to absolute survival after cardiac resynchronization therapy?
" Open Access Journal of Plastic Surgery,  February 2014 ",ePlasty,Use of Bacteria- and Fungus-binding Mesh in NPWT,Pathogen-binding mesh may be a viable alternative to foam and gauze as a wound filler in NPWT.
  February 2014 ,American Journal of Clinical Dermatology,Treatment of Hereditary Epidermolysis Bullosa,"While there is currently no effective therapy or cure for epidermolysis bullosa, a number of recent advances have been made that may bring new hope to sufferers of this disfiguring disease."
  February 2014 ,Future Microbiology,Leprosy as a Model of Immunity,"In this review, the authors present M. leprae as a model for investigating the role of the human immune system in host defense and susceptibility to infection."
  February 2014 ,Pediatric Critical Care Medicine,Effort of Breathing in Children on High-Flow Nasal Cannula,Find out about an objective measure of breathing effort to evaluate high-flow humidified nasal cannula use in critically ill children.
  February 2014 ,Spine,Changes in Spinal Cord Compression by Cervical OPLL,"Using kinematic CT myelography images, the authors assess the dynamic factors in patients with cervical myelopathy due to OPLL."
  February 2014 ,Brain,Diagnosis of Guillain-Barre Syndrome: The Brighton Criteria,"In this article, the authors describe in detail the key diagnostic features required to meet the recently proposed Brighton criteria for diagnosis of Guillain-Barre syndrome."
  February 2014 ,Clinical Endocrinology,Association of Paternal Age on Stature and Lipids in Kids,What physical and metabolic characteristics do children have who are born to men over 35?
  February 2014 ,Annals of Family Medicine,Expectations of Antibiotics for Upper RT Infections,This qualitative study aimed to explore how and why family physicians elicit and address patients' or parent's expectations for antibiotics for upper respiratory tract infection.
  February 2014 ,Neurosurgical Focus,Therapeutic Options in Asymptomatic Carotid Artery Stenosis,This review looks at the evidence for -- and controversy surrounding -- both medical and surgical approaches to management of asymptomatic carotid artery disease.
  February 2014 ,Eye,Outcomes of Corneal Collagen Crosslinking Treatment,"How successful is corneal crosslinking treatment in patients with progressive keratoconus, and what are some of the factors that could influence outcomes?"
  February 2014 ,The British Journal of Dermatology,Comparison of Worldwide Melanoma Guidelines,This review looks at the evidence and available literature for the management of melanoma worldwide. How do guidelines differ among the major expert groups?
  February 2014 ,American Heart Journal,Cilostazol Use Plus Dual Antiplatelet After Biolimus-Eluting Stent,Does 3 months of cilostazol use improve 1-yr clinical outcome above dual antiplatelet therapy alone?
  February 2014 ,Annals of Oncology,Increased Cancer Risk From Commonly Used Medications,Are current medication and cancer-link claims valid?
  February 2014 ,Laboratory Investigation,Programmed Death Ligand-1 Expression in NSCLC,This paper describes a reproducible method of measuring programmed death ligand-1 protein and mRNA and demonstrates the prognostic relevance of these biomarkers in non-small cell lung cancer.
  February 2014 ,HIV Medicine,Effect of ART Initiation Time on HIV/TB Coinfection Outcomes,This study evaluates whether the interval between the initiation of ART and the initiation of anti-tuberculosis treatment in HIV/tuberculosis-coinfected patients has an effect on clinical outcomes.
  February 2014 ,Journal of the American Board of Family Medicine,Effects of Ginger for Nausea and Vomiting in Early Pregnancy,Is ginger safe and effective for the relief of morning sickness?
  February 2014 ,Clinical Endocrinology,Is Hyperthyroidism Associated With Cognitive Dysfunction?,Does hyperthyroidism adversely affect cognition? What does the research find?
  February 2014 ,Spine,Utilization of Cervical Artificial Disc Replacement vs ACDF,How prevalent is the use of cervical disc arthroplasty compared with ACDF? This study takes a look at the utilization rates after FDA approval of CDA devices.
  February 2014 ,Pediatric Critical Care Medicine,Acute Respiratory Distress Syndrome in Children,"Surfactant therapy has become a routine for neonatal respiratory care and already proved to reduce morbidity and mortality in neonatal respiratory distress syndrome. Should it be used in children, too?"
  February 2014 ,Cancer Control: Journal of the Moffitt Cancer Center,Lung Cancer Screening,"What's an acceptable risk in screening for lung cancer, the leading cause of cancer death in the US?"
  February 2014 ,The British Journal of Dermatology,Bimodal Immune Activation in Psoriasis,"Is psoriasis a complex of related diseases, as sometimes proposed, or a single entity with a bimodal immunopathology?"
  February 2014 ,American Heart Journal,2 Types of Epoprostenol for Pulmonary Arterial Hypertension,Is this novel and stable IV epoprostenol formulation also well tolerated by patients with pulmonary arterial hypertension?
  February 2014 ,Journal of the American College of Cardiology,Rosuvastatin for Contrast-Induced Nephropathy in ACS,Patients with acute coronary syndrome are at high risk for contrast induced acute kidney injury. Find out more about the role of statin pre-treatment in preventing renal damage.
  February 2014 ,HIV Medicine,Telaprevir-Based Triple Therapy for HIV/HCV Coinfection,This study compares the effectiveness of telaprevir-based triple therapy for hepatitis C in patients with and without HIV coinfection.
  February 2014 ,BMC Dermatology,Comparison of Publication Trends in Dermatology in Asia,"This study compared the characteristics of publications over ten year period in dermatology in mainland China, South Korea and Japan. Are publications increasing in quantity and quality?"
  February 2014 ,Current Orthopaedic Practice,Artificial Cervical Disc Arthroplasty vs ACDF,Is artificial cervical disc arthroplasty a safe alternative to ACDF? This review explores the issue.
  February 2014 ,Journal of Pediatric Health Care,"Postpartum Depression, Infant Feeding and Weight",Does postpartum depression affect infant feeding and weight gain?
  February 2014 ,Journal of the American Board of Family Medicine,Aspirin for Prevention of Cardiovascular Events,"Recent evidence has indicated that the use of aspirin for primary prevention of cardiovascular events is ineffective, and potentially harmful.  Are physicians heeding new guidelines?"
  February 2014 ,Spine,Adjacent Segment Disease After ACDF,A new study compares the long-term outcomes of patients who underwent repeat ACDF procedures due to adjacent segment disease. What are the results?
  February 2014 ,Alimentary Pharmacology & Therapeutics,Controversies in Cholestatic Diseases,Are clinicians conflicted on the best management strategies for both primary biliary cirrhosis and primary sclerosing cholangitis? This new study explores the best treatment options as well as the current controversies.
  February 2014 ,The Journal of Emergency Medicine,Can Plain Radiographs Exclude Cervical Spine Injuries?,Plain radiographs may not be the best option for detecting cervical spine injuries in otherwise low-risk patients.
  February 2014 ,International Journal of Impotence Research,Link Between Erectile Function and Sexual Self-Confidence,How can erectile function impact sexual confidence? This study investigates the issue in men treated with the PDE-5 inhibitor tadalafil.
  February 2014 ,Infection Control and Hospital Epidemiology,Healthcare Personnel Attire in Non-Operating-Room Settings,Is your work attire spreading infection? This article examines the relationship between healthcare personnel attire and healthcare associated infection.
  February 2014 ,Journal of Viral Hepatitis,Chronic Hepatitis E: A Review of the Literature,Chronic hepatitis E infection -- from the microbiological aspect through overall disease management -- is reviewed.
  February 2014 ,Human Reproduction,Severe Depressive Symptoms and Infertility-related Distress,How common is it for patients and their partners undergoing infertility treatments to also experience severe depression?
  March 2014 ,Annals of Clinical Microbiology and Antimicrobials,Antifungal Activity of Farnesyltransferase Inhibitors,"This study investigated the antifungal potential of mamumycin A, a farnesyltransferase inhibitor, against Aspergillus and Candida."
  March 2014 ,The British Journal of Dermatology,Antidrug Antibodies in Psoriasis: A Systematic Review,This review examines the prevalence and impact of antidrug antibodies against biological agents used in the treatment of psoriasis. Can their formation be prevented?
  March 2014 ,Clinical Endocrinology,Relative Risk for Goiter in Euthyroid Patients With T2DM,Does insulin or metformin increase the risk of goiter in patients with diabetes?
  March 2014 ,Alimentary Pharmacology & Therapeutics,Linaclotide for the Management of IBS With Constipation,Are there any particularly effective drugs on the market to treat constipation that presents in patients with IBS? This new study describes.
  March 2014 ,Clinical Lipidology,Treatment of Homozygous Familial Hypercholesterolemia,Find out more about this relatively rare disease with reduced receptor-mediated catabolism of LDL causing high plasma LDL cholesterol and premature coronary artery disease.
  March 2014 ,American Journal of Public Health,Rural-Urban Differences in Nonmedical Prescription Opioid Use,"Why is nonmedical prescription opioid misuse more prevalent in rural areas than in urban areas, and why is it on the increase?"
  March 2014 ,Personalized Medicine,Antidepressant-Induced Suicidality and Pharmacogenetics,Will pharmacogenomics help determine who is least likely to have treatment-associated risks with SSRIs?
  March 2014 ,BMC Musculoskeletal Disorders,Effectiveness of Abatacept for RA in Europe and Canada,IV abatacept may be a safe and effective therapeutic option for patients with moderate-to-severe rheumatoid arthritis.
  March 2014 ,Journal of the American Board of Family Medicine,MALAdaptive: Do We Avoid Metformin Unnecessarily?,"The use of metformin is often avoided in diabetic patients due to the fear of lactic acidosis, a potentially serious adverse effect. Is this fear justified?"
  February 2014 ,Clinical Journal of Sport Medicine,PRP in the Management of Articular Cartilage Pathology,How beneficial are autologous PRP injections in treating osteochondral pathologies?
  February 2014 ,Current Opinion in Psychiatry,Differentiating Bipolar II Disorder From Borderline PD,"While differentiating bipolar I disorder from borderline personality disorder is relatively straightforward, diagnosing bipolar II is more challenging. What clinical differences can help pin it down?"
  February 2014 ,American Journal of Transplantation,Diagnosis and Management of Antibody-Mediated Rejection,"Learn more about the spectrum of antibody-mediated rejection after kidney transplantation, including its pathogenesis, risk factors, and phenotypes."
  February 2014 ,Future Oncology,"Nintedanib, Afatinib and Sequential Combination in CRPC",Is this combo's anti-tumor-activity enough to impact advanced castration-resistant prostate cancer?
  February 2014 ,Kidney International,Summary of KDIGO 2012 CKD Guideline,"What do the latest clinical guidelines say about the pathophysiology of chronic kidney disease, and the best ways to manage and treat it?"
  February 2014 ,American Heart Journal,Balloon Aortic Valvuloplasty in the Era of TAVI,What's the long-view on outcomes in patients treated with balloon aortic valvuloplasty -- in the period since TAVR was developed?
  February 2014 ,Journal of the American College of Cardiology,Heart Failure With Preserved Ejection Fraction,Find out more about coexisting angina and heart failure. How does comorbidity-coexistence impact patient outcomes?
  February 2014 ,Journal of Gastroenterology and Hepatology,Folate Intake and the Risk of Upper Gastrointestinal Cancers,What does the latest science tell us about the possible connection between folate intake and the risk for developing upper gastrointestinal cancer?
  February 2014 ,Journal of Pediatric Psychology,Becoming a Pediatric Psychologist: A Winding Road,"The author describes her career path as a pediatric psychologist from the 1970s to the present. How has the field evolved over the last 40 years, and what does the future hold?"
  February 2014 ,European Heart Journal,Follow-up of Remotely Monitored ICD Recipients,"For patients with prophylactic ICD placement, automatic daily remote monitoring may reduce the burden of office visit follow-ups."
  February 2014 ,BMC Clinical Pathology,Should Prophylactic Thrombolysis Be Routine With a CVC?,"Catheter-related thrombosis is known to be a frequent complication of central venous lines, and may introduce Candida infection. Should prophylactic thrombolysis be routine?"
  March 2014 ,Pharmacogenomics,Pharmacogenetics-Based Warfarin Dosing in Children,This review describes the two main types of pharmacogenetic-based warfarin dose prediction models and their applicability to children. What are their respective advantages and limitations?
  March 2014 ,Annals of Oncology,Short-term Psychotherapy for Depressed Breast Cancer Patients,Find out more about psychodynamic therapy in non-metastatic breast cancer patients with depression.
  March 2014 ,Alimentary Pharmacology & Therapeutics,The Impact of Hepatitis C Burden,"How much of a burden does hepatitis C place on the patient, on the healthcare system, and on society in general?"
  March 2014 ,Nursing Economics,The Impact of Research on Staffing,Learn more about a keen vision for future directions in staffing.
  March 2014 ,BMC Family Practice,Lower Urinary Tract Symptoms in Men and CVD,This longitudinal study investigated the relationship between lower urinary tract symptoms in men and cardiovascular diseases. Is there an association?
  March 2014 ,AIDS,"Cancers in HIV/AIDS: Epidemiology, Therapeutic Challenges",This article reviews the epidemiology and etiology of cancers seen in HIV/AIDS.
  March 2014 ,Alimentary Pharmacology & Therapeutics,Inflammatory Bowel Disease in the Elderly,"Does IBD present uniquely in elderly patients, and does it require a different treatment strategy?"
  March 2014 ,Current Orthopaedic Practice,The Progression of Total Knee Arthroplasty From 1993-2013,This review takes a look at the recent advances and emerging technologies in total knee arthroplasty.
  March 2014 ,BMC Musculoskeletal Disorders,Non-displaced Distal Radial Fractures in Adult Patients,"In patients with non-displaced distal radial fractures, can cast immobilization be safely reduced to three weeks?"
  March 2014 ,Critical Care Medicine,Two Decades of Mortality Trends in Severe Sepsis,Compare time trends in severe sepsis mortality using both clinical trial data and administrative data -- to find out if we're saving more lives today.
  March 2014 ,Breast Cancer Research,BreastMark: Transcriptomic Datasets and Breast Cancer Outcome,Find out more about this powerful tool for examining miRNA prognostic markers in breast cancer.
  March 2014 ,Menopause,Venous Thromboembolism Risk Among Postmenopausal Women,"Does the age at which a woman reaches menopause, as well as her reproductive history, put her at an increased risk for venous thromboembolism? This new article takes a look at the connection."
  March 2014 ,European Heart Journal,Atrial Fibrillation Treated With Vitamin K Antagonism,How does rivaroxaban compare with warfarin for reductions in cardiovascular events -- in patients with atrial fibrillation and a prior MI?
  March 2014 ,Journal of Gastroenterology and Hepatology,Personalized Chronic Hepatitis C Treatment,Could IL28B genotyping move us closer to personalized hepatitis C treatment in the forthcoming era of direct-acting antivirals?
  March 2014 ,Alimentary Pharmacology & Therapeutics,Sofosbuvir in the Treatment of Chronic Hepatitis C,What's the efficacy and safety of sofosbuvir-containing regimens in the treatment of chronic hepatitis C?
  March 2014 ,Journal of Cardiovascular Electrophysiology,Circumferential Pulmonary Vein Isolation in Paroxysmal AF,"Find out more about rapid firing in pulmonary veins, a leading cause of paroxysmal atrial fibrillation. . ."
  March 2014 ,Nanomedicine,Nanotoxicity: An Obstacle to siRNA-Based Nanomedicine,"siRNAs have immense therapeutic potential for the treatment of various gene-related diseases, but the safety of the nanocarriers necessary for their delivery is a challenge to be overcome."
  March 2014 ,International Journal of Clinical Rheumatology,The Future of Treatment for Psoriatic Arthritis,An increased knowledge of psoriatic disease has stimulated the development of targeted biologic medications.
  March 2014 ,Current Opinion in Infectious Diseases,Global Resistance of Neisseria gonorrhoeae,The control of gonorrhoea is failing at the global level. We are in desperate need of novel antimicrobial agents and a gonococcal vaccine.
  March 2014 ,BMC Psychiatry,Cost-effectiveness of Asenapine for Bipolar Disorder,"Asenapine, a tetracyclic antipsychotic, has shown a comparable efficacy profile to other atypical antipsychotics for treatment of bipolar disorder. How does it compare in cost?"
  April 2014 ,HIV Medicine,ART and the Risk of Clinical Depression in HIV+ Patients,How does ART affect risk for depression in HIV+ patients?
  March 2014 ,American Heart Journal,Patterns of Medical Management Strategy in NSTEMI and CAD,Is there a standard threshold for the use of revascularization in NSTEMI patients with 3VD/LMD?
  March 2014 ,Neurosurgical Focus,Near-Complete Resection of Brain Tumors Using Tumor Paint,"The authors describe a proof-of-concept intraoperative near-infrared imaging system to detect a novel tumor ligand with a high affinity for glioma, potentially enabling near-complete tumor removal."
  March 2014 ,Nephrology Dialysis Transplantation,Iron Toxicity: Relevance for Dialysis Patients,Could intravenous iron supplementation put hemodialysis patients at risk for iron toxicity? This new study explores the potential safety concerns.
  March 2014 ,Menopause,Hormone Therapy and Risk of Cardiovascular Events in Women,"Does hormone therapy raise the risk of cardiovascular events in women, and what role does dosage and route of delivery play in this possible risk?"
  March 2014 ,Future Oncology,Sentinel Lymph Node Biopsy in Melanoma,Get current data regarding patient selection for SLNB in melanoma and learn about areas where the procedure remains controversial. . .
  March 2014 ,BMC Pulmonary Medicine,A COPD Biopsy Trial With Roflumilast,How well does roflumilast reduce the characteristic inflammation of COPD in patients with moderate-to-severe COPD?
  March 2014 ,Current Opinion in Neurology,TBS to Promote Functional Recovery After Stroke,"Noninvasive brain stimulation shows great promise in enhancing post-stroke recovery, but many questions must be answered before it can be effectively targeted and tailored to the individual patient."
  March 2014 ,Journal of the American College of Cardiology,"ACE Inhibitor, ARB, and Mortality in Chronic Kidney Disease",What's the connection between angiotensin-converting enzyme inhibitor/angiotensin receptor blocker use and mortality in patients with chronic kidney disease?
  March 2014 ,Journal of Cardiovascular Electrophysiology,Real-time Contact Force Sensing for PVI in Paroxysmal AF,Does real-time contact force sensing 'reel in' the number of redo-interventions to maintain sinus rhythm?
  March 2014 ,International Journal of Clinical Practice,Treatment Outcomes for Benign Prostatic Obstruction,This study compared the benefits of surgical vs. medical therapy for treatment of lower urinary tract symptoms due to BPH.
  March 2014 ,International Journal of Clinical Rheumatology,Recent Advances in the Treatment of SLE,This article reviews the current and future treatment options for SLE.
  March 2014 ,Alimentary Pharmacology & Therapeutics,Anti-adhesion Therapies for Inflammatory Bowel Disease,"How effective are new monoclonal antibodies in the treatment of IBD, and how do they compare with immunosuppressive agents prescribed in the past?"
  March 2014 ,Current Opinion in Infectious Diseases,Current Thinking on Genital Herpes,Recent advances in our understanding of genital herpes may help guide new strategies for disease prevention and control.
  March 2014 ,Diabetes Care,Antibiotics vs Surgery for Diabetic Foot Osteomyelitis,Do all patients with diabetic foot osteomyelitis require surgical intervention?
  March 2014 ,Cardiovascular Diabetology,Residual Macrovascular Risk in 2013: What Have We Learned?,"Are PPAR agonists, CETP inhibitors, and PCSK9 inhibitors the future of cardiometabolic risk reduction?"
  March 2014 ,American Heart Journal,Hemorrhagic Risk and Bivalirudin vs UFH in PCI,"What's the impact of bivalirudin compared with UFH on the rates of mortality, myocardial infarction, and major bleeding?"
  March 2014 ,Pediatric Pharmacotherapy,Micafungin Use in the Treatment of Pediatric Fungal Infections,Is Micafungin an effective treatment for Candida species infections in children?
  March 2014 ,The Pediatric Infectious Disease Journal,Afebrile Very Young Infants With UTI and Risk for Bacteremia,Is fever a predictor for bacteremia in very young infants with UTIs?
  March 2014 ,Personalized Medicine,Whole-Exome Sequencing in Pediatric Endocrinology,Read how next-generation sequencing can help diagnose growth disorders in children.
  April 2014 ,Diabetes,Complications & Mortality in People With T2DM & CVD or Risks,Does C-reactive protein predict mortality risk in patients with diabetes and heart disease?
  April 2014 ,Clinical Journal of Oncology Nursing,Triple-Negative Breast Cancer: What Is Known About It?,This article provides suggestions for nurses as they guide women who are experiencing an atypical breast cancer diagnosis with an uncertain prognosis and limited treatment options.
  April 2014 ,Journal of the National Cancer Institute,Chemotherapy Usage Patterns in Metastatic Colorectal Cancer,Find out what treatment trends are emerging in metastatic colorectal cancer.
  March 2014 ,AccessMedicine from McGraw-Hill,Trametinib: An Oral MEK Inhibitor for Metastatic Melanoma,"The FDA recently approved trametinib, a first-in-class, oral MEK inhibitor for patients with unresectable or metastatic melanoma with BRAF V600/K mutations. What are the implications?"
  April 2014 ,European Heart Journal,The Year in Cardiology 2013: Heart Failure,Is there a new dawn of hope for acute heart failure therapy?
  April 2014 ,Spine,Outcomes After Microdecompression of Spinal Stenosis,This new study takes a look at the postoperative outcome 5 years after interspinous microdecompression for lumbar spinal stenosis. What are the results?
  April 2014 ,Current Opinion in Allergy and Clinical Immunology,Early Weight Gain Asthma and Atopy in Children,Learn more about the comorbid connection between weight gain and asthma in infancy.
  April 2014 ,Journal of Perinatology : Official Journal of the California Perinatal Association,Preterm Infant Outcomes Following Intracranial Hemorrhage,What variables could predict outcomes for extremely preterm infants with intracranial hemorrhage?
  April 2014 ,BMC Musculoskeletal Disorders,Trunk Muscle Activation During Abdominal Hollowing In CLBP,"In this study, the muscle activation patterns of chronic low back pain patients during the abdominal hollowing maneuver are examined."
  April 2014 ,BMC Neurology,Chronic Inflammatory Demyelinating Polyradiculoneuropathy,Chronic inflammatory demyelinating polyradiculoneuropathy is a rare acquired immune-mediated peripheral neuropathy. Are there any effective therapies?
  April 2014 ,BMC Pulmonary Medicine,Exhaled Breath Condensate in Idiopathic Pulmonary Fibrosis,Is there such a thing as biomarker-breath -- in patients with pulmonary fibrosis?
  April 2014 ,Endocrine Practice,Insulin Treatment Persistence Among Patients With T2DM,What patient factors influence adherence to insulin therapy?
  April 2014 ,Clinical Gastroenterology and Hepatology,Rational Helicobacter pylori Therapy,What is the current recommended regimen for the treatment of H. pylori disease?
  April 2014 ,International Ophthalmology Clinics,Ocriplasmin and Vitreoretinal Interface Disorders,Learn about the safety and efficacy of intravitreal ocriplasmin for vitreomacular adhesion.
  April 2014 ,Clinical Endocrinology,Exenatide's Effect on Beta-cell Function in New Onset T2DM,Does daily GLP-1 receptor agonist use improve beta-cell function?
  April 2014 ,Alimentary Pharmacology & Therapeutics,Tenofovir vs Entecavir for Viral Suppression in Chronic HBV,"Is there a difference between 2 antivirals, tenofovir and entecavir, in the treatment of HBeAg-positive chronic hepatitis B?"
  April 2014 ,Annals of Oncology,Adjuvant Radiotherapy Impact in Primary Breast Cancer,Just how vital is guideline-adherent adjuvant radiotherapy -- for improving survival in primary breast cancer?
  April 2014 ,Pacing and Clinical Electrophysiology,Interference Between Medical and Field Devices Is Real,Are numerous telecommunication systems and our lack of knowledge creating an electromagnetic mine-field?
  April 2014 ,European Heart Journal,Haemodynamic Effects of Serelaxin in Acute Heart Failure,Do the hemodynamic effects of serelaxin provide plausible mechanistic support for improvement in signs and symptoms of acute heart failure?
  April 2014 ,BMC Psychiatry,Reducing Symptoms of MDD Through Systematic Training,This study evaluates the impact on depressive symptoms of a group-based training which targets general emotion regulation skills.
  April 2014 ,Nephrology Dialysis Transplantation,Hypertension in Hemodialysis Patients,Is atenolol-based antihypertensive therapy superior to lisinopril-based therapy in preventing cardiovascular morbidity in hemodialysis patients?
  April 2014 ,Clinical Lipidology,"Adipose Tissue, Inflammation and Atherosclerosis","Extensive research in recent decades has revealed manifold metabolic functions of adipose tissue, beyond its purpose as a simple storage organ for fatty acids."
  April 2014 ,Current Opinion in Nephrology and Hypertension,Are Diuretics Harmful in the Management of AKI?,This new study explores the safety of diuretics in the treatment of acute kidney injury. What does the latest research reveal?
  April 2014 ,European Heart Journal,The Year in Cardiology 2013: Arrhythmias,Don't miss this current review of top arrhythmia-related happenings from a most electric year.
  April 2014 ,Pediatric Critical Care Medicine,Analgesia-Sedation in PICU and Neurological Outcome,Does the use of opioids during PICU admission correlate with long-term adverse neuropsychological outcomes in meningococcal septic shock survivors?
  April 2014 ,Clinical Endocrinology,Response in Cushing's Syndrome Treated With Mifepristone ,What are strong drivers of response to mifepristone therapy in patients with Cushing disease?
  April 2014 ,Annals of Surgery,Surgical Skills Transfer After Simulation-Based Training,Do skills acquired through simulation-based training transfer to the operating room?
  April 2014 ,Eye,Visual Outcomes in DME Treated With Ranibizumab,Why do some DME patients continue to have poor vision after ranibizumab therapy? This new study examines the issue.
  April 2014 ,Europace,Current Periprocedural Management of Atrial Fibrillation Ablation,Are your practice patterns for atrial fibrillation ablation patient-prep up-to-speed?
  April 2014 ,European Heart Journal,Catheter Ablation vs Antiarrhythmic Agent for Persistent AF,Compare the effectiveness of catheter ablation vs antiarrhythmic drug therapy in treating persistent atrial fibrillation.
  April 2014 ,Diabetes Care,Microalbuminuria as a Risk Predictor in Diabetes,Do you screen your patients with cardiovascular disease for microalbuminuria? This research suggests that you should.
  April 2014 ,Cardiovascular Diabetology,Do Incretins Improve Endothelial Function?,Read how GLP-1 agonists and DPP-4 inhibitors may protect the cardiovascular system.
  April 2014 ,BMC Musculoskeletal Disorders,The Impact of Low Back Pain on People's Lives,It is important for clinicians to consider the social factors associated with this condition and the ways it can influence quality of life.
  April 2014 ,BMC Psychiatry,When Eating Healthy Is Not Healthy: Orthorexia Nervosa,Is orthorexia nervosa -- an condition in which a person is excessively preoccupied and obsessed with eating only healthy food -- a valid subtype of eating disorder?
  April 2014 ,Cancer Control: Journal of the Moffitt Cancer Center,Therapies for Early-stage Lung Cancer,"Even with aggressive surgical treatment, relapse rates remain high for patients with resectable non-small-cell lung cancer. . ."
  April 2014 ,Pediatric Pharmacotherapy,Everolimus Use in Children With Tuberous Sclerosis Complex,Everolimus has been found to be a valuable tool in the management of children with tuberous sclerosis complex.
  April 2014 ,AIDS,ART Use and Kidney Function: Clinical Practice Implications,What effect does antiretroviral therapy have on the kidney?
  April 2014 ,Neurosurgical Focus,Applications of Fluorescent Technology in Neurosurgery,"There's been tremendous excitement regarding the use of targeted fluorescent agents in neurosurgery. But as this commentary suggests, near-infrared technology also has its challenges."
  April 2014 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Impact of HBV/HCV on Hospitalization in HIV+ Persons,Does hepatitis coinfection increase health care utilization among persons living with HIV?
  April 2014 ,American Journal of Public Health,The State of Transgender Health Care,"What are some of the specific healthcare needs of the transgendered community, and how can clinicians work together to ensure that the needs are met?"
  April 2014 ,Current Opinion in Rheumatology,Antineutrophil Cytoplasm Antibody-Associated Vasculitis,What new therapies are coming down the pipeline for the treatment of antibody-associated vasculitis?
  April 2014 ,European Heart Journal,Family History of Premature Cardiovascular Disease,Does inclusion of family history of CVD improve prognostics?
  April 2014 ,BMC Musculoskeletal Disorders,Meniscus Body Position and Its Change in Asymptomatic Adults,Learn more about the meniscal position in asymptomatic knees. How does it change over time?
  April 2014 ,Journal of Viral Hepatitis,Resistance and Response in HCV Genotype 1 Subtypes,How do response rates and resistance patterns for approved and investigational direct-acting antivirals differ between the 2 major HCV genotype 1 subtypes?
  April 2014 ,Social Cognitive and Affective Neuroscience,Emotion Processing Efficiency in Healthy Males vs. Females,Do females and males process emotions using different neural pathways? This neuroimaging study compared processing of facial emotions in male and female subjects.
  April 2014 ,Journal of the American College of Cardiology,STEMI Treated by Radial or Femoral Approach,"Radial access may have better outcomes than femoral, operator experience can still tips the scales."
  March 2014 ,Spine,In-Hospital Outcomes in Cervical Spine Surgery,Find out how cervical spine surgery is trending and how it impacts patient outcomes.
  April 2014 ,Rheumatology,Safety Issues With Bisphosphonate Therapy for Osteoporosis,"Studies have shown that bisphosphonates improve BMD and reduce fracture risk, but various safety issues were not addressed."
  April 2014 ,Gastroenterology,Cancer Risk With Adalimumab in Crohn's Disease,"Are patients with Crohn's disease taking anti-TNF agents, either as a monotherapy or in combination with other drugs, at an increased risk for developing malignancies? This new study investigates."
  April 2014 ,Alimentary Pharmacology & Therapeutics,HCV Genotype 3 -- The New Treatment Challenge,"Hepatitis C genotype 3 can be a difficult disease to treat. What options, besides antivirals and pegylated interferon, are available to clinicians?"
  April 2014 ,BMC Musculoskeletal Disorders,Screening of the Spine in Adolescents,Are these clinical tests reliable tools for the screening of child and adolescent spines?
  April 2014 ,HIV Medicine,Atazanavir Resistance With Unplanned Treatment Interruptions,This study examines the emergence of resistance to boosted PI-containing ART after multiple unplanned treatment interruptions.
  April 2014 ,BMC Pulmonary Medicine,Determinants of Arterial Stiffness in COPD,What's the recipe for prediction of arterial stiffness in patients with COPD?
  April 2014 ,Critical Care Medicine,Multibiomarker Outcome Risk Model for Septic Shock,Learn more about a validated risk stratification tool that reliably estimates the probability of mortality in adults with septic shock.
  April 2014 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Task Shifting for the Delivery of Pediatric ART,Task shifting is now a broadly practiced approach to improve access to ART in HIV+ adults. Could this approach benefit pediatric patients?
  April 2014 ,International Journal of Clinical Practice,Lone Atrial Fibrillation -- An Overview,The term 'lone' atrial fibrillation has been used to describe AF in younger individuals without any apparent cardiac disease. What are its clinical implications?
  April 2014 ,Seminars in Respiratory and Critical Care Medicine,Biomarkers in CTD-Associated Interstitial Lung Disease,Learn more about major biomarkers with respect to their diagnostic and prognostic value in connective tissue disease-associated interstitial lung disease (CTD-ILD).
  April 2014 ,Skin Therapy Letter,Steroid-Sparing Properties of Emollients in Dermatology,This review looks at a variety of alternatives to steroids with similar anti-inflammatory and barrier repair properties for use in the treatment of inflammatory dermatoses.
  April 2014 ,American Journal of Transplantation,Pain Identifies Squamous Cell Carcinoma in Organ Transplant,Learn to define clinically meaningful warning signals predicting the invasive cutaneous squamous cell carcinomas -- in transplant recipients.
  April 2014 ,Future Oncology,Molecular Imaging in Recurrent Prostate Cancer,About a third of men with localized prostate cancer who are treated with EBRT or radical prostatectomy may develop distant metastasis. Find out how imaging may help to reign this in.
  April 2014 ,Current Opinion in Psychiatry,Amyloid-Based Immunotherapy for Alzheimer's Disease?,This review summarizes the latest clinical trials on active and passive anti-beta-amyloid immunotherapy for the treatment of Alzheimer's disease. Where do we stand?
  April 2014 ,Journal of Clinical Rheumatology,Variations and Practice in the Care of Patients With RA,There is a wide range of practice variability by rheumatologists in the management of RA. What implications does this variability have on cost of care?
  April 2014 ,BMC Pulmonary Medicine,Early Discharge in Adults With Respiratory Infection,"Is early discharge really feasible, for patients with pneumonia and lower respiratory tract infection?"
  April 2014 ,Medicine and Science in Sports and Exercise,Exercise as Medicine in the Management of Pancreatic Cancer,This case study describes the beneficial effects of an exercise program in a pancreatic cancer patient undergoing adjuvant treatment.
  April 2014 ,BMC Musculoskeletal Disorders,Subacromial Impingement Syndrome and Pain,The SUPPORT trial investigates the long-term outcome and cost-effectiveness of these two interventions for subacromial impingement syndrome.
  April 2014 ,Brain,Restoration of Sensorimotor Functions in Spinal Cord Injury,"The authors examine dual approaches to the rehabilitation of sensorimotor functions after spinal cord injury, highlighting key challenges and areas of particular promise."
  April 2014 ,BMC Pulmonary Medicine,Quality of Life and Fitness in Cystic Fibrosis,What kind of physical fitness has the biggest impact on quality of life for patients with cystic fibrosis?
  April 2014 ,Diabetes Care,T2DM Prevention in Prediabetes Patients Using PHEN/TPM,Can use of weight loss medications reduce the risk of diabetes?
  April 2014 ,Eye & Contact Lens,Dry Eye Disease Management in Current Clinical Practice,A survey of eye care providers provides insight into the preferred diagnostic and treatment strategies for dry eye. Do practice patterns differ from current recommendations?
  April 2014 ,Annals of Family Medicine,"Physical Therapy for Low Back Pain: What Is It, and When Do We Offer It to Patients?","This commentary proposes a low-cost approach to screening for and stratification of low-back pain in primary care, with referral of appropriate patients to physical therapists."
  April 2014 ,Immunotherapy,Broadly Neutralizing Antibodies and Universal Vaccines,Could broadly neutralizing antibodies be effectively used as a form of passive immunotherapy for HIV and influenza?
  April 2014 ,The Journal of Emergency Medicine,Management of Benign Paroxysmal Positional Vertigo,Vestibular rehabilitation with the canalith repositioning maneuver offers an alternative to medication in benign paroxysmal positional vertigo.
  April 2014 ,Journal of the International Association of Providers of AIDS Care,Low Skeletal Muscle Mass in Virally Suppressed HIV Patients,This study looks at predictors of low skeletal muscle mass in middle-aged HIV-infected persons stably receiving combination antiretroviral therapy.
  April 2014 ,BMC Clinical Pathology,High Expression of miRNA-21 in Node Positive NSCLC,Does miRNA-21 expression have prognostic value in non-small cell lung cancer?
  April 2014 ,American Heart Journal,Hemodynamic Support With Impella 2.5 vs IABP in High-Risk PCI,What's the learning curve associated with initial introduction of the Impella 2.5. Clinical trials?
  March 2014 ,Pharmacogenomics,Pharmacogenomics of Oral Antiplatelet Drugs,Should pharmacogenetic testing be done before prescribing antiplatelet drugs for coronary artery disease? This review presents the latest evidence.
  April 2014 ,American Journal of Public Health,Previous Exposure to HCV Among Persons Born During 1945-1965,"What accounts for the high prevalence of HCV infection among persons born during 1945-1965, and how can clinicians ensure proper treatment for this cohort of patients?"
  April 2014 ,Alimentary Pharmacology & Therapeutics,The Efficacy of Anti-TNF Agents for Ulcerative Colitis,Does this latest study advocate the use of anti-TNF agents in the treatment of ulcerative colitis?
  February 2014 ,Journal of the National Cancer Institute,"Aspirin, NSAIDs, and Acetaminophen and Ovarian Cancer Risk ",Does a low-dose aspirin-a-day keep ovarian cancer at bay?
  April 2014 ,Current Opinion in Gastroenterology,Advances in Celiac Disease,"As celiac disease becomes more prevalent, what does the newest research tell us about the pathophysiology of the disease, including in children, and how it is most effectively diagnosed?"
  May 2014 ,Journal of the American Geriatrics Society,25-Hydroxyvitamin D and Cognitive Function in Older Adults,Is vitamin D supplementation beneficial to cognitive function in older adults?
  May 2014 ,American Journal of Cardiovascular Drugs,Management of Microvascular Angina Pectoris,"Patients with stable MVA have excellent long-term prognoses, but often present with persistent and/or worsening of angina symptoms. What gives?"
  May 2014 ,BMC Pulmonary Medicine,Esomeprazole and Pulmonary Exacerbations in Cystic Fibrosis,Do proton pump inhibitors promote pulmonary exacerbations in patients with cystic fibrosis?
  May 2014 ,Spine,Opioids vs Other Treatments for Chronic Low Back Pain,How do opioids compare with other methods of pain management? This review examines the evidence for treating chronic low back pain.
  May 2014 ,European Heart Journal,Everolimus-Eluting Bioresorbable Vascular Scaffolds for STEMI,What's the feasibility of the everolimus-eluting bioresorbable vascular scaffolds for the treatment of patients presenting with STEMI?
  May 2014 ,Journal of the American College of Cardiology,Comparison of Wave-Free Ratio and Resting Pd/Pa With FFR,Zero-in on the diagnostic accuracy of instantaneous wave-free ratio (iFR) and resting distal coronary artery pressure/aortic pressure (Pd/Pa) with respect to hyperemic fractional flow reserve (FFR).
  May 2014 ,BMC Musculoskeletal Disorders,"The Efficacy of Duloxetine, NSAIDs, and Opioids in OA",Is duloxetine superior to other commonly used oral treatments for osteoarthritis?
  April 2014 ,Alimentary Pharmacology & Therapeutics,The Incidence of Advanced Neoplasia After Polypectomy,What is the impact of post-polypectomy surveillance colonoscopy on colorectal cancer incidence and mortality?
  April 2014 ,Europace,LV Lead Stabilization to Retain CRT at Long Term,Is it possible to predict lead dislodgement?
  April 2014 ,HIV Medicine,Mortality of HIV+ Youth Following Transition to Adult Care,What can be done to decrease the mortality rate of perinatally infected young HIV patients after transitioning to adult care?
  April 2014 ,BMC Psychiatry,Delayed Sleep Onset in Depressed Young People,This study explored the prevalence and patterns of delayed sleep onset among depressed young people. How did substance use factor in?
  April 2014 ,BMC Musculoskeletal Disorders,"Adverse Events After Manual Therapy for Neck, Back Pain",A new study takes a look at the occurrence of adverse events after manual treatment for neck or back pain. Which are the most common?
  April 2014 ,Arthritis Research & Therapy,NK4 Therapy: A New Approach to RA Treatment,NK4 treatment could be a possible therapeutic option in combating RA.
  April 2014 ,Kidney International,The Roles of GLP-1R Signaling in Diabetic Nephropathy,"What does this latest study tell us about the role of GLP-1 in the pathogenesis of diabetic nephropathy, and how could clinicians use this information to treat patients?"
  April 2014 ,AIDS,Impaired Semen Quality in HIV Patients Under Stable ART,This study investigates the impact of HIV and ART on sperm quality and protein composition.
  April 2014 ,Wounds,Laparoscopic Compared to Open Gastrectomy,Compare long-term oncologic results of performing laparoscopic vs open gastrectomy.
  April 2014 ,Immunotherapy,Influenza Vaccination in Immunocompromised Patients,"Learn about the clinical significance of the influenza virus infection and vaccine safety in HIV infected individuals, solid-organ and stem-cell transplant recipients and patients receiving biological agents."
  April 2014 ,Current Opinion in Pulmonary Medicine,Tuberculosis: Clinical Trials and New Drug Regimens,Be in-the-know with this TB drug update.
  April 2014 ,Current Opinion in Neurology,Antiepileptogenesis in Humans: Ways to Move Forward,"While there are many effective anti-seizure drugs, none have been shown to prevent epilepsy after stroke, TBI, or in brain tumors. What's the status of research, and where do we go from here?"
  April 2014 ,American Heart Journal,Target Vessel Revascularization in Older Patients Undergoing PCI,Find out more about determining the need for repeat revascularization in older patients after PCI.
  May 2014 ,BMC Urology,"Surgeon Variability Affects Oncologic, Functional Outcomes",A new study explores the outcome variations following radical prostatectomy for prostate cancer. How do they differ between surgeons?
  May 2014 ,Human Reproduction,IVF Culture Medium and Post-natal Weight in Humans,"Does the culture medium used in IVF affect the long-term growth, development, and health of IVF children?"
  May 2014 ,American Journal of Transplantation,Donor-Specific HLA Alloantibodies in Liver Transplantation,"Advances in intensive care, immunosuppression, and disease management have dramatically improved liver allograft survival. What role is played by donor-specific HLA antibodies?"
  May 2014 ,Current Opinion in Ophthalmology,"AREDS2: Perspectives, Recommendations, and Questions","This review offers a perspective on the findings from the AREDS2 trial. The results are in, but important questions remain."
  May 2014 ,Nephrology Dialysis Transplantation,Ferric Carboxymaltose for Anemia and Impaired Renal Function,How well do patients with anemia and impaired renal function respond to ferric carboxymaltose? This new study looks at recent data.
  May 2014 ,BMC Pulmonary Medicine,Timing of Noninvasive Ventilation Failure,"What are the causes, risk factors and potential remedies of non-invasive ventilation failure?"
  May 2014 ,American Journal of Clinical Pathology,SATB2 as a Diagnostic Marker for Tumors of Colorectal Origin,This study indicates that the SATB2 protein may serve as a promising marker for determining colorectal origin of metastatic cancers.
  May 2014 ,BMC Ophthalmology,Overnight Orthokeratology Compared With Atropine in Myopia,The authors investigate the efficacy of these two methods in controlling the progression of myopia. How do they compare?
  May 2014 ,Headache,1-Day Behavioral Intervention in Depressed Migraine Patients,Can a one-day workshop targeting psychological flexibility help patients with comorbid migraine and depression?
  May 2014 ,Diabetes Care,The Reality of Type 2 Diabetes Prevention,Do community-based programs really prevent type 2 diabetes?
  May 2014 ,BMC Musculoskeletal Disorders,The Clinical Course of Low Back Pain,A new study sheds light on the clinical course of low back pain and uncovers a pattern in the results of RCTs and observational studies.
  May 2014 ,BMC Family Practice,Chronic Conditions Among Multimorbid Patients in Primary Care,Many older people have multiple chronic conditions. To what extent is there agreement between self-reported and physician-reported chronic conditions among multimorbid patients?
  May 2014 ,Pacing and Clinical Electrophysiology,Effect of Anxiety and Depression on Symptoms Attributed to AF,"Learn more about the crossroads of depression, anxiety, and atrial fibrillation."
  May 2014 ,Wounds,Serial Sharp Debridement of Diabetic Foot Ulcers,What's the net effect of debridement with clostridial collagenase ointment and debridement --for foot ulcers in patients with diabetes.
  May 2014 ,The Journal of Emergency Medicine,Review of Hypnosis for Clinical Emergency Care,"Does hypnosis have a place in emergency medicine? If so, why is it not more widely used?"
  May 2014 ,Diabetes,Limited Recovery of Beta-Cell Function After Gastric Bypass,Is improvement in beta-cell function after gastric bypass mediated by the GI tract?
  May 2014 ,American Heart Journal,Contraindications to Oral Anticoagulation in Atrial Fibrillation,What factors are associated with oral anticoagulant contraindications & how do they influence prescribing practices?
  May 2014 ,The Journal of Invasive Cardiology,Predictors of Complications During Chronic Total Occlusion PCI,"Find out more about clinical, angiographic, and procedural factors associated with increased risk of periprocedural complications during chronic total occlusion percutaneous coronary intervention."
  May 2014 ,Current Opinion in Allergy and Clinical Immunology,Eosinophils in the Pathogenesis of Paediatric Severe Asthma,Find out why children with asthma shouldn't be treated as smaller versions of adults.
  May 2014 ,American Journal of Critical Care,Arterial Catheter for Glucose Control in Critically Ill,Is blood from an arterial catheter safe and effective for glucose monitoring -- in patients on intensive insulin therapy?
  May 2014 ,Pain Management Nursing,Pain Prevalence and Management in Pediatric Population,"New research, regulatory guidelines, and practice initiatives have improved pain management in infants, children, and adolescents, but obstacles remain. . ."
  May 2014 ,Seminars in Respiratory and Critical Care Medicine,Rheumatoid Arthritis and Lung Disease,What do you know about the connections between rheumatoid arthritis and lung disease?
  May 2014 ,Rheumatology,Udenafil vs Amlodipine in Secondary Raynaud's Phenomenon,Is udenafil or amlodipine more effective in the treatment of secondary Raynaud's phenomenon?
  May 2014 ,Annals of Oncology,Megestrol in Advanced Breast Cancer Postmenopause,"Megestrol acetate has a longstanding history in the treatment of breast cancer, but recently it's  being used less often due to the advent of newer agents. Can this relative bargain make a comeback -- in the third world?"
  May 2014 ,Europace,Applicability of the Iterative Technique for CRT Optimization,Gain insight into the guideline driven use of iterative atrioventricular delay optimization in patients undergoing cardiac resynchronization therapy.
  May 2014 ,Personalized Medicine,Genotype-Guided Use of Oral Antithrombotic Therapy,Do the genetic factors that affect warfarin metabolism also affect the novel oral anticoagulants?
  May 2014 ,BMC Anesthesiology,Three Techniques for Ultrasound Guided Femoral Nerve Block,What is the optimal positioning of the local anesthetic for a femoral nerve block?
  May 2014 ,Alimentary Pharmacology & Therapeutics,Treatment Costs in Ulcerative Colitis and Crohn's Disease,How much of a burden does the treatment of ulcerative colitis and Crohn's disease place on our healthcare system? This new study explains.
  May 2014 ,BMC Musculoskeletal Disorders,Endoscopic Treatment for Lumbar Infectious Spondylitis,"In this report, a new minimally invasive technique for lumbar infectious spondylitis is described. Is this approach an effective alternative to open surgery?"
  May 2014 ,BMC Psychiatry,Comorbidity of Dementia,What are the common comorbidities associated with dementia in older patients?
  May 2014 ,HIV Medicine,Management of CV Conditions and Diabetes HIV+ Adults,What are the risks of combining antiretroviral treatment with drugs prescribed for cardiovascular disease and diabetes in HIV-infected patients?
  May 2014 ,The British Journal of Dermatology,Diagnosing and Treating Psoriatic Arthritis: An Update,"Psoriatic arthritis affects approximately one in four patients with psoriasis, and can cause severe disability. What should the dermatologist know about diagnosis and management?"
  May 2014 ,Cardiovascular Diabetology,Liraglutide Decreases Carotid IMT in Patients With T2DM,Does this GLP-1 receptor agonist decrease subclinical atherosclerosis?
  May 2014 ,European Heart Journal,Prognostic Models for Stable Coronary Artery Disease,Could these prognostic models be used in clinical practice to support risk stratification for patients with CAD?
  May 2014 ,Wounds,Topical Combination Therapy in Wound Healing,See comparative images of wounds treated with topical oxygen therapy and negative pressure vs those treated with saline irrigation.
  May 2014 ,BMC Clinical Pathology,Colorectal Cancer in Guadeloupe and Martinique,Colorectal cancer in Guadeloupe and Martinique has increased five-fold in 25 years. Do clinicopathological characteristics differ between the 2 nations?
  May 2014 ,Chinese Clinical Oncology,Biomarker Threshold Selection and Independent Evaluation,Development of targeted therapies is accelerating in response to widespread identification of hypothesized biomarkers.
  May 2014 ,Journal of Viral Hepatitis,Efficacy and Safety of Telaprevir Triple Therapy for HCV,Is telaprevir triple therapy considered to be safe and effective for patients with HCV genotype 1?
  May 2014 ,American Journal of Clinical Dermatology,Medical Adherence to Acne Therapy: A Systematic Review,Why is there so often poor adherence to acne therapy?
  May 2014 ,International Journal of Clinical Practice,GLP-1 Receptor Agonists vs. DPP-4 Inhibitors for T2DM,This review examines the clinical differences and similarities between the two primary drug classes for treatment of type 2 diabetes mellitus. When is each most appropriate?
  May 2014 ,Malaria Journal,Imported falciparum Malaria Among Adults in the ICU,This article reviews available data to guide clinicians caring for adults with imported malaria in an intensive care unit.
  May 2014 ,BMC Infectious Diseases,Point-of-Care Urine Test for TB Screening Among HIV+ Adults,How accurate is the rapid urine LAM test for TB screening among newly-diagnosed HIV-infected adults?
  May 2014 ,Future Virology,Antiviral Vaginal Rings for Preventing HIV in Women,Could this device be the solution to HIV prevention in women?
  May 2014 ,Eye & Contact Lens,Topical Tacrolimus 0.03% in Vernal Keratoconjunctivitis,How effective is topical tacrolimus alone in the treatment of vernal keratoconjunctivitis? This study compares the efficacy of this agent when used alone or combined with olopatadine.
  May 2014 ,BMC Pulmonary Medicine,Beclomethasone/Formoterol vs Fluticasone/Salmeterol in COPD,Find out which inhaler combo is quicker on the draw -- for breath in patients with COPD.
  May 2014 ,Cardiovascular Diabetology,Cardiovascular MicroRNAs and Diabetic Heart Disease,Can microRNA be used to detect heart disease earlier in patients with diabetes?
  May 2014 ,European Heart Journal,Pentaerithrityl Tetranitrate in Chronic Stable Angina,Will adding PETN improve exercise tolerance in patients with chronic stable angina?
  May 2014 ,Diabetes Care,SGLT2 Inhibition and Glycemic Control in Type 1 Diabetes,Are SGLT2 inhibitors safe and effective in type 1 diabetes?
" Open Access Journal of Plastic Surgery,  May 2014 ",ePlasty,"Single Use PICO NPWT Device on Surgical, Traumatic Wounds",Learn more on this novel NPWT system and how it can benefit postoperative and posttraumatic wounds.
  May 2014 ,Future Cardiology,Optimal Aspirin Dose in Acute Coronary Syndromes,"The complex antiplatelet therapy landscape makes it difficult to identify the optimal aspirin dose for minimizing risk, while complying with the clinical guidelines."
  May 2014 ,Annals of Family Medicine,Therapeutic Massage for Chronic Neck Pain,Are patients who undergo therapeutic massage for chronic neck pain receiving a sufficient dose? What's the optimal frequency and session length for relief?
  May 2014 ,Neurosurgical Focus,The Early Days of Hemostasis in Neurosurgery,The authors review the historical progression of hemostatic techniques since the beginning of the early modern era of neurosurgery.
  May 2014 ,The Journal of Invasive Cardiology,TAVI in Patients With LV Dysfunction,What are the outcomes of patients with severe aortic stenosis and left ventricular dysfunction undergoing TAVI?
  May 2014 ,Diabetes,Cardiac Arrhythmias During Hypoglycemia in T2DM with CV Risk,"Why does hypoglycemia trigger arrhythmias, and who is at risk?"
  May 2014 ,Exercise and Sport Sciences Reviews,Restoring Symmetry: Clinical Applications of Cross-Education,"Learn more on the 'restoring symmetry' hypothesis, and what role this approach can play in neurologic and orthopedic rehabilitation."
  May 2014 ,Journal of the National Cancer Institute,Baseline Selenium Status and Effects of Selenium and Vitamin E,What amount of vitamin E and selenium should men consume to reduce prostate cancer risk?
  May 2014 ,Endocrine Practice,Treatment of Gastroenteropancreatic Neuroendocrine Tumors,"Neuroendocrine tumor treatment now includes hormone therapy, chemotherapy, and targeted biologic therapy."
  May 2014 ,BMC Pulmonary Medicine,Impact of Prevalence and Severity of COPD on Lung Cancer,Recent studies suggest that coexistence of chronic obstructive pulmonary disease (COPD) might be independently related to a worse prognosis for lung cancer.
  May 2014 ,BMC Musculoskeletal Disorders,Computer-Assisted Surgery and Alignment in Revision TKA,How does the use of computer-assisted surgery in revision TKA affect postoperative prosthetic alignment?
  May 2014 ,Cardiovascular Diabetology,Cardiovascular Safety of Saxagliptin in Patients With T2DM,Does this DPP-4 inhibitor increase risk of myocardial infarction or stroke?
  May 2014 ,BMC Pulmonary Medicine,Non-Pharmacologic Interventions for Asthma During Pregnancy,Are non-drug therapy options effective for pregnant women with asthma?
  May 2014 ,Cardiovascular Diabetology,Cardiovascular Guidelines: Attenuating Controversy,Are clinical guidelines you rely on free of financial conflict of interest? Probably not. How can this controversial issue be fixed?
  May 2014 ,Journal of Cardiovascular Electrophysiology,Ablation for Persistent AF Without Circumferential PVI,Find out about the clinical outcome of a pure linear ablation approach without circumferential pulmonary vein isolation over 5-plus years follow-up.
  May 2014 ,Critical Care Medicine,Efficacy and Safety of Prone Positional Ventilation in ARDS,Does ventilation in the prone position reduce mortality in patients with severe ARDS?
  May 2014 ,BMC Urology,Simvastatin Improves Sexual Health QoL in Older Men With ED,"In a secondary analysis, researchers found that older men with ED who took 40 mg of simvastatin daily realized a significantly improved sexual health-related quality of life."
  May 2014 ,American Journal of Pharmaceutical Education,Evolution of Self-care Education,Are pharmacists prepared to educate the increasing number of patients taking OTC medications?
  May 2014 ,Respiratory Research,"Changes in Gene Expression From Patients With Asthma, Rhinitis",Discover more about how dsRNA changes transcriptional profiles of primary nasal and bronchial epithelial cells - from patients with allergic rhinitis.
  May 2014 ,The Gerontologist,"Elder Abuse: Research, Practice, and Health Policy","This paper examines the epidemiology of elder abuse -- whether psychological, physical, sexual, or by neglect -- and its implications for future research, practice, and policy."
  May 2014 ,Journal of the National Cancer Institute,Survival in Cancer Patients in and out of Clinical Trials,What's the relationship between trial participation and clinical outcomes for cancer patients?
  May 2014 ,BMC Anesthesiology,Predicting Mortality in Bacteremic Patients With Shock,What factors are capable of impacting hospital mortality in patients with septic shock?
  May 2014 ,AccessMedicine from McGraw-Hill,Treatment of Hepatitis C: At Last the Holy Grail,"Finally, effective treatment can be achieved using an oral tablet containing 2 direct-acting antiviral agents. Read this quick overview."
  May 2014 ,Journal of Clinical Rheumatology,OMERACT Measurement for Chronic Gout Studies,What are the most important concerns of patients with gout?
  May 2014 ,American Journal of Clinical Pathology,Low ER+ Breast Cancer: Is This a Distinct Group?,Are breast cancers expressing ER at low levels different from the usual ER+ tumors? This study looked at the morphologic characteristics of this uncommon subset of breast cancers.
  May 2014 ,BMC Pulmonary Medicine,Benefits of Whole-Body Vibration to People With COPD,Find out how this non-pharmacologic therapy creates ripples of good vibrations -- in patients with COPD.
  May 2014 ,Cardiovascular Diabetology,Liraglutide-Induced Body Changes & Cardiac Markers,New research sheds light on how weight loss occurs in patients receiving GLP-1 agonists.
  May 2014 ,European Heart Journal,Choline/Betaine Prognostics Depend on Trimethylamine-N-Oxide,Find out why these biomarkers for coronary heart disease should always go with their gut. . .
  May 2014 ,Emerging Infectious Diseases,HPV in Oropharyngeal Cancer Before Vaccine Introduction,What impact has the HPV vaccine had on oropharyngeal cancer?
  May 2014 ,Clinical Journal of Oncology Nursing,Gastrointestinal Nurse Navigation: A Novel Role,Get tips on developing a GI Nurse Navigator role as part of a multidisciplinary GI cancer program & find out more about the importance of tracking specific quality metrics.
  May 2014 ,Rheumatology,PEGylated Drugs in Rheumatology,"What PEGylated drugs are currently available for use in rheumatological diseases? This article reviews their efficacy, drawbacks current clinical trials."
  May 2014 ,International Journal of Epidemiology,Preventing the Onset of Major Depressive Disorder,Is major depression preventable? This meta-analysis of preventive interventions aimed to determine what might work.
  June 2014 ,International Ophthalmology Clinics,Obesity and Weight Reduction in IIH,How much weight loss is necessary to relieve symptoms of intracranial hypertension?
  June 2014 ,Cardiovascular Diabetology,Distribution of CVD and Retinopathy in Patients With T2DM,Do new classification systems for CKD underestimate the burden of CVD and retinopathy in patients with diabetes?
  June 2014 ,Diabetes,Proinsulin-Transferrin Fusion Protein as an Insulin Analog,This new insulin analog is specific to the liver. Will it offer advantages over conventional insulin?
  June 2014 ,Nanomedicine,Lipid-Based Nanomedicines for Type-Specific Ovarian Cancer,"Epithelial ovarian cancers are currently all treated with the same chemotherapeutic regimen, but delivery via lipid-based nanoparticles has the potential to allow greater specificity by cancer subtype."
  June 2014 ,Respiratory Research,Comorbid Factors That Increase COPD Assessment Scores,What does it mean for patients with COPD to have a 'high CAT'?
  June 2014 ,BMC Musculoskeletal Disorders,Clinical Study of the Pronator Quadratus Muscle,Gain a better understanding of the anatomical features of the pronator quadratus muscle and the viability of PQ muscle sparing surgery for distal radius fractures.
  June 2014 ,Pediatric Pharmacotherapy,Methylnaltrexone for Opioid-Induced Constipation in Children,Is methylnaltrexone an effective treatment option for children with opioid induced constipation?
  May 2014 ,Journal of the American Geriatrics Society,MoCA-MIS Predicts Conversion From MCI to Alzheimer's Disease,This study evaluated the efficacy of a widely used 10-minute cognitive screening test in predicting which individuals with MCI are at high risk of conversion to Alzheimer's disease.
  May 2014 ,Journal of the National Cancer Institute,Better Therapeutic Trials in Ovarian Cancer,"Review strategies to improve early-phase screening, therapeutic evaluation, and more for clinical trials -- in response to an evolving landscape of scientific, regulatory, and funding priorities."
  May 2014 ,AccessMedicine from McGraw-Hill,Imaging in the Diagnosis of Disorders of Consciousness,Can imaging and electrophysiologic techniques help distinguish between patients with persistent vegetative state and those in a minimally conscious state?
  May 2014 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Importance of Hospital Entry: Walk-in STEMI and Primary PCI,Which patients with STEMI do better? Those who arrive by ambulance or those who walk in?
  May 2014 ,Clinical Endocrinology,Longitudinal Changes in HDL and CV Events in Older Adults,Does a significant decrease in HDL increase risk of CV disease in patients older than 50?
  May 2014 ,BMC Gastroenterology,Altering Lifestyle to Reduce Risk of Colorectal Cancer,"When patients are at a high risk for developing colorectal cancer, how likely are they to alter their lifestyle choices to help prevent the disease? This new study take a look."
  May 2014 ,Current Opinion in Neurology,TMS for the Diagnosis and Treatment of Epilepsy,"Recent advances have shown TMS to be a valuable tool with diagnostic, prognostic and therapeutic potential in the field of epilepsy."
  May 2014 ,Kidney International,New Magnetic Resonance Imaging Methods in Nephrology,"How is MRI used for renal function imaging, and how can clinicians ultimately use MRI for the diagnosis and monitoring of major kidney diseases?"
  May 2014 ,Personalized Medicine,"Cancer Pharmacogenomics, Adoption by Oncologists and Benefit",Do oncologists need more information about cancer pharmacogenomics testing?
  May 2014 ,Alimentary Pharmacology & Therapeutics,Budesonide-MMX for Mild-to-Moderate Ulcerative Colitis,"Should clinicians consider adding the glucocorticosteroid, budesonide-MMX, to treatment regimens for mild-to-moderate ulcerative colitis?"
  May 2014 ,BMC Musculoskeletal Disorders,Self-administered Tests for Pelvic Girdle Pain in Pregnancy,Are self-administered tests an effective means of identifying pelvic girdle pain in pregnant women?
  May 2014 ,BMC Neurology,Sex of Acute Stroke Patients and Effectiveness of rt-PA,Do women show more frequent recanalization and better recovery after intravenous rt-PA treatment for acute stroke compared with men?
  May 2014 ,Pharmacogenomics,How Common Are Drug and Gene Interactions?,"Drug-drug interactions are a widely recognized cause of adverse drug reactions, but drug-gene interactions can be a potential source of ADRs as well. How common are they?"
  June 2014 ,Headache,Pediatric Headache,"This article presents a comprehensive overview of pediatric headache, from epidemiology, genetics, and classification to diagnosis, treatment options, and prevention strategies."
  June 2014 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,HIV Outcomes in HBV Coinfected Individuals on HAART,How does HBV coinfection affect the outcomes in HIV patients receiving HAART?
  June 2014 ,Critical Care Medicine,Interaction of Vasopressin and Corticosteroids in Septic Shock,What's the real story between vasopressin and corticosteroids in septic shock?
  June 2014 ,AIDS,Impact of ART Response on Life Expectancy in HIV+ Adults,This study estimates life expectancies of HIV-positive patients according to response to antiretroviral therapy.
  June 2014 ,Current Opinion in Nephrology and Hypertension,Safety of Medical Therapy in Patients With CKD and ESRD,"Is medical therapy safe in patients with CKD and ESRD, and how can clinicians ensure that the medications they're prescribing don't produce dangerous adverse events?"
  June 2014 ,Pediatric Critical Care Medicine,Safety of Sildenafil in Infants,How safe and effective is this repurposed erectile dysfunction therapy -- as an option for the treatment of pulmonary hypertension in young infants?
  June 2014 ,Eye,Anti-VEGF Agents for Proliferative Diabetic Retinopathy,This review summarizes evidence on the use of anti-VEGF agents in the treatment of proliferative diabetic retinopathy.
  June 2014 ,BMC Urology,Nadir PSA Levels Are Prognostic Factors in Prostate Cancer,Learn more on the role nadir PSA values play in predicting the prognosis of patients with metastatic prostate cancer.
  June 2014 ,Applied Radiology,New PET Tracers for Dementia Evaluation,"Two new amyloid imaging tracers are proving useful in amyloid PET imaging for AD diagnosis, but limitations must be addressed before this tool can significantly enhance diagnostic accuracy."
  June 2014 ,American Journal of Transplantation,DDAs for Chronic HCV Infection in Liver Transplant Patients,"Direct acting antiviral agents provide new opportunities for treatment of HCV recurrence, but are there pitfalls?"
  June 2014 ,BMC Ophthalmology,Cost-Effectiveness of the Argus II Retinal Prosthesis,Is this retinal prosthesis more economically advantageous than usual care for treating retinitis pigmentosa?
  June 2014 ,Journal of the American Geriatrics Society,Surgical Care and Complications in Elderly Adults,"This study compared the distribution of surgical cases and outcomes in five age categories. How did procedures, hospitals visited, and complications differ according age?"
  June 2014 ,Current Opinion in Rheumatology,Safety Profile of Anti-gout Agents: An Update,This review highlights recent data on the safety of drugs used in gout.
  June 2014 ,European Heart Journal,Heart Failure With Preserved Ejection Fraction,Does heart failure with preserved ejection fraction simply represent a collection of co-morbidities rather than a pathophysiologically distinct entity?
  June 2014 ,American Journal of Public Health,Outcomes Related to Third Molar Removal or Retention,"Prophylactic removal of asymptomatic third molars in young adults is common, but remains controversial. How do long-range outcomes compare for removal vs. retention?"
  June 2014 ,American Heart Journal,Drivers of Hospitalization for Patients With AF,Learn more about the frequency and predictors of hospitalization in patients with AF.
  June 2014 ,Oncology Nursing Forum,Pegfilgrastim-Induced Pain in Patients With Lymphoma,"Growth factors, such as pegfilgrastim or filgrastim, have reduced the incidence, duration, and severity of chemotherapy-related neutropenia, but what are the common side effects?"
  June 2014 ,Annals of Surgery,Benchmarking Outcomes in the Critically Injured Burn Patient,"This study serves as a benchmark in burn care, comparing interventions, outcomes and mortality among major burn patients."
  June 2014 ,Alimentary Pharmacology & Therapeutics,Fecal Microbiota Transplantation in Adults and Children,"How safe and effective is fecal microbiota transplantation for various gastrointestinal diseases in both adults and children, and is it becoming a common treatment?"
  June 2014 ,Future Virology,Dengue Vaccine Development: Challenges and Opportunities,Where are we in the progression toward an effective dengue vaccine?
  June 2014 ,American Journal of Kidney Diseases,Nephropathy in Illicit Drug Abusers: A Postmortem Analysis,Could intravenous drug users be at an increased risk for nephropathy and chronic kidney disease? This new study explores the connection.
  June 2014 ,Pain Management Nursing,Older Adults' Pain Communication During Medical Visits,How much time should you allow older patients for pain-talk?
  June 2014 ,Annals of Surgery,Safety Delays Before Surgery for Acute Appendicitis,"Short organizational delays before appendicectomy may improve provision of surgical services, but is the delay safe for the patient?"
  June 2014 ,Rheumatology,Maintenance Therapy of Lupus Nephritis With MMF or AZA,Is mycophenolate or azathioprine a better choice for maintenance therapy in patients with lupus nephritis?
  June 2014 ,BMC Family Practice,CRP Testing in Acute Cough/Respiratory Tract Infection,Could routine CRP testing in patients with acute cough or respiratory tract infection reduce antibiotic prescribing and further diagnostics without compromising outcomes?
  June 2014 ,International Journal of Impotence Research,Effects of Daily Low-Dose PDE5 Treatment in ED Patients,Find out about the additional beneficial effects of daily dosing with the PDE5 inhibitor udenafil in patients with ED.
  June 2014 ,Journal of Cardiovascular Electrophysiology,Estimated Local Conduction Velocity in Atrial Flutter,Get the facts on correlates related to the atrial flutter reentry circuit in the right atrium.
  June 2014 ,BMC Endocrine Disorders,Association Between MetS and Fractures: A Meta-analysis,Are patients with metabolic syndrome at risk for fractures?
  June 2014 ,Journal of the American College of Cardiology,Optimal Medical Therapy Goals for US Adults With CAD,What percentage of patients with CAD have optimal risk factor management?
  June 2014 ,Diabetes Care,Intensive vs Intermediate Glucose Control in SICU Patients,Does intensive glucose control decrease the risk of surgical site infections in SICU patients?
  June 2014 ,BMC Musculoskeletal Disorders,Effects of Exercise on Depression in Rheumatic Disease,Could exercise improve depressive symptoms in patients with rheumatic diseases? This review examines the effects.
  June 2014 ,Nanomedicine,Liposomes Targeted to Dendritic Cells for Cancer Vaccines,This review presents a novel targeted vaccine strategy to activate and deliver antigens to dendritic cells in advanced cancers.
  June 2014 ,The Journal of Invasive Cardiology,Transradial vs Transfemoral Coronary Intervention for AMI,"When cardiogenic shock occurs after AMI, which access point is safer for PCI?"
  June 2014 ,BMC Infectious Diseases,Increased Incidence of Invasive Bacterial Disease in COPD,What is the association between COPD and invasive bacterial infection?
  June 2014 ,Seminars in Respiratory and Critical Care Medicine,Pulmonary Manifestations of Systemic Lupus Erythematosus,"Learn more about the clinical presentation, pathogenesis, pathology, management, and prognosis of these SLE-associated lung conditions."
  June 2014 ,BMC Gastroenterology,Barriers Impeding Serologic Screening for Celiac Disease,"What are some of the reasons why patients may not get tested for celiac disease, and how can these rates be improved upon?"
  June 2014 ,European Heart Journal,CT Angiography and Perfusion to Assess Coronary Artery Stenosis,Find out about a perfect pairing to identify patients with flow limiting CAD.
  June 2014 ,Rheumatology,Role of DMARDs in Reducing Immunogenicity of TNF Inhibitors,Concomitant MTX may reduce the immunogenicity of anti-TNFs in chronic inflammatory diseases.
  June 2014 ,Personalized Medicine,Recent Advances in Antiplatelet Pharmacogenomics,How do genetic polymorphisms affect metabolism of antiplatelet agents and subsequent risk of bleeding?
  June 2014 ,Alimentary Pharmacology & Therapeutics,Postoperative Crohn's Disease Maintenance,Are thiopurines and anti-TNF agents recommended in the prevention of postoperative Crohn's disease recurrence?
  June 2014 ,European Heart Journal,Diuretic Response in Acute Heart Failure,Find out what factors have the greatest impact on the effectiveness of diuretics in acute heart failure.
  June 2014 ,Future Microbiology,Immunization for P. Aeruginosa in Critically Ill Patients,Pseudomonas aeruginosa is one of the most common causes of nosocomial infection in intensive care unit patients. Where do we stand on vaccine development?
  June 2014 ,BMC Infectious Diseases,Predicting Embolic Events in Infective Endocarditis,What factors are associated with the risk of embolism in patients with infective endocarditis?
  June 2014 ,Skin Therapy Letter,Rosacea: An Update on Medical Therapies,"Rosacea, a common, chronic cutaneous condition affecting the face, can create embarrassment, anxiety, and low self-esteem. What therapies are currently available?"
  June 2014 ,Journal of Pediatric Psychology,Mindfulness and Acute Experimental Pain Among Adolescents,This study tested a novel mindful attention manipulation on adolescent's pain responses. Can it ameliorate pain outcomes?
  June 2014 ,Critical Care Medicine,Corticosteroids and Delirium in Acute Lung Injury,"Outside the ICU setting, corticosteroids are a recognized risk factor for delirium, but what's their relationship with delirium in critically ill patients?"
  June 2014 ,European Heart Journal,Bone Marrow Cells and CABG for Myocardium Regeneration,Does adding bone marrow cells during CABG improve LV function and clinical symptoms?
  June 2014 ,BMC Pulmonary Medicine,Exacerbations in Patients With COPD Receiving Physical Therapy,Does protocol-directed physical therapy prevent and/or postpone COPD exacerbation?
  June 2014 ,Journal of the American College of Cardiology,Prognostic Value of BARC Bleeding Complications in STEMI,Learn more about comparisons of BARC-defined bleeding complications with existing bleeding definitions -- in patients with STEMI.
  June 2014 ,Medicine and Science in Sports and Exercise,Mediators of Exercise Effects on Fatigue in Cancer Survivors,Gain a better understanding of the mediators of exercise intervention effects on cancer-related fatigue.
  June 2014 ,The Journal of Invasive Cardiology,Fractional Flow Reserve and Coronary Flow Reserve,"Functional assessment of coronary lesions requires diagnostic parameters like fractional flow reserve and coronary flow reserve, but stenosis hemodynamics might require a different approach . . ."
  June 2014 ,American Journal of Epidemiology,Changes in LDL Cholesterol Levels After Acute MI,The findings of this study support the use of intensive statin therapy in post-MI patients to reduce the risk of recurrent ischemic events and death.
  June 2014 ,Emerging Infectious Diseases,Characteristics of Primary Pulmonary Coccidioidomycosis,"This study examines characteristics of patients with coccidioidomycosis with hopes to better guide diagnosis, treatment, and prognosis."
  June 2014 ,BMC Infectious Diseases,Oral Antibiotic Therapy for Treating Infective Endocarditis,Are oral antibiotics effective when treating infective endocarditis?
  June 2014 ,Alcohol and Alcoholism,Genetic and Environmental Interplay in Adolescent Drinking,"This study reviewed recent research on the interplay of genes, environment and epigenetic factors in risky drinking in adolescents.  What role do these factors play in neurobiological development?"
  June 2014 ,Infection Control and Hospital Epidemiology,Preventing C. diff Infections in Acute Care Hospitals,What strategies can be used to prevent the spread of C. diff infection in acute care hospitals?
  June 2014 ,Cardiovascular Ultrasound,Ischemic Mitral Regurgitation: Predictors and Prognosis,This study aimed to determine the predictors and prognosis of early ischemic mitral regurgitation after percutaneous coronary intervention for ST-elevation myocardial infarction.
  June 2014 ,Current Opinion in Rheumatology,Uricosuric Drugs: Once and Future Therapy for Hyperuricemia?,Promising new drugs could increase the renal clearance of uric acid and thereby provide better control of hyperuricemia.
  June 2014 ,Clinical Endocrinology,Effect of 25(OH) D in PHPT & Coexistent Vitamin D Deficiency,Does correction of vitamin D deficiency cause hypercalcemia and hypercalciuria in patients with primary hyperparathyroidism?
  June 2014 ,Journal of the American College of Cardiology,Post-FDA Approval Study With a Continuous Flow LVAD,Are results with the HeartMate II LVAD in a commercial setting comparable to results during clinical trials?
  July 2014 ,Clinical Endocrinology,Impulse Control & Dopamine Agonist-Treated Prolactinomas,Are patients receiving dopamine agonists for prolactinomas at risk for compulsive shopping and pathologic gambling?
  July 2014 ,BMC Endocrine Disorders,Prevalence and Determinants of Osteoporosis in Diabetes,Are patients with diabetes at increased risk for osteoporosis?
  July 2014 ,European Heart Journal,Remote vs in-Person Monitoring for ICD Follow-Up,Which follow up method is better for patient retention? The answer may surprise you. . .
  July 2014 ,The Pediatric Infectious Disease Journal,Pediatric Chagas Disease in Europe,"Pediatric Chagas disease is an emerging health issue in Europe, but clinician still lack awareness to the problem."
  July 2014 ,Alimentary Pharmacology & Therapeutics,The Efficacy of Anti-TNF Agents to Treat Crohn's Disease,Does the latest research tell us anything new about the efficacy of anti-TNF agents in the treatment of Crohn's disease?
  July 2014 ,Journal of Viral Hepatitis,Treating Hepatitis C in Patients With Schizophrenia,What special considerations should be taken into account in the treatment of patients with hepatitis C who also have been diagnosed with schizophrenia?
  July 2014 ,BMC Family Practice,Persistent Medically Unexplained Physical Symptoms,How common are patients with persistent MUPS--defined as conditions characterized by symptoms without corresponding objective findings--in general practice?
  July 2014 ,BMC Oral Health,Adjunctive Chlorhexidine Mouthrinse in Gingivitis,This study assessed the effect of a microbicidal mouthrinse on matrix metalloproteinases known to contribute to periodontal disease.
  July 2014 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Phenytoin Toxicity From Cocaine Adulteration,"Phenytoin (PHT) is commonly used as a cocaine adulterant, but can lead to toxic effects. In this case, a patient developed PHT toxicity after ingesting adulterated crack cocaine."
  July 2014 ,European Heart Journal,Cardiac MRI in Identifying Ventricular Arrhythmia Substrate,What's the clinical value of analyzing ventricular scar tissue to find an ablation approach in patients with ventricular arrhythmias?
  July 2014 ,The British Journal of Dermatology,Epidemiology and Comorbidities of Severe Acne in Adolescence,"Do racial, ethnic, and socioeconomic differences impact the prevalence of severe acne? What medical comorbidities are commonly seen in adolescents with severe acne?"
  June 2014 ,Menopause,Testosterone in Hysterectomized Women,"What does the latest research tell us about the safety and efficacy of testosterone for the treatment of sexual dysfunction, physical dysfunction, and osteoporosis in postmenopausal women?"
  July 2014 ,Southern Medical Journal,Vitamin D Insufficiency/Deficiency Management,"Vitamin D deficiency is increasingly recognized in patients, but there's been no consensus on treatment regimens. How should Vitamin D deficient patients be managed?"
  June 2014 ,Diabetes,Circadian Misalignment & Markers of Insulin Resistance,Does shift work increase the risk of diabetes?
  June 2014 ,Schizophrenia Bulletin,Sexual Trauma and Risk of Psychosis in Prodromal Population,Is sexual trauma an important contributing factor in development of psychosis for certain high-risk individuals?
  June 2014 ,Arthritis Research & Therapy,Adalimumab in Patients With RA and Over 5 Years of Therapy,This large observational study evaluates the long-term safety and effectiveness of adalimumab.
  June 2014 ,Current Opinion in Neurology,Migraine and Estrogen,"Although the association between migraine and sex hormones has been repeatedly demonstrated, the exact pathophysiology has not yet been fully elucidated. What do we know?"
  June 2014 ,Annals of Oncology,Bevacizumab-Pemetrexed for Advanced Nonsquamous NSCLC,Learn more about the safety and efficacy of bevacizumab maintenance with or without pemetrexed in nonsquamous nonsmall-cell lung cancer.
  June 2014 ,BMC Infectious Diseases,Oral Antibiotic Regimen After IV Treatment for Osteomyelitis,IV antibiotics are often used for treatment of vertebral osteomyelitis.  When is it safe to switch to oral antibiotics?
  June 2014 ,Clinical Endocrinology,IGF-II: Its Role in Metabolic and Endocrine Disease,"Previously considered physiologically irrelevant, what does research now say about the function of insulin-like growth factor-II and its role in disease?"
  July 2014 ,Pediatric Critical Care Medicine,Citrate Anticoagulation and Renal Replacement Therapy in PICU,Find out how to avoid risks of using regional citrate anticoagulation in the pediatric critical care population requiring renal replacement therapy.
  July 2014 ,Journal of the American College of Cardiology,Early Stent Thrombosis in Patients With ACS,Learn more about the impact of thrombus burden and suboptimal stent implantation as a trigger of early stent thrombosis.
  July 2014 ,Clinical Lipidology,Recalcitrant Hypercholesterolemia With Best Standard of Care,Find out what to do when guideline based therapy isn't hitting the mark for cholesterol reduction.
  July 2014 ,Nephrology Dialysis Transplantation,Differential Scaling of GFR and Ingested Metabolic Burden,"Do men generally have more adverse outcomes in chronic kidney disease than women, and is there a way to estimate what the outcomes may be?"
  July 2014 ,Journal of Pediatric Psychology,Pediatric eHealth Interventions: Common Challenges,"There are many challenges pediatric researchers face when planning, developing, testing, and conducting eHealth interventions. What are the crucial issues and how can they be overcome?"
  July 2014 ,Future Neurology,Time to Open the Blood-Brain Barrier Gate for Biologics?,Recent advances in our understanding of the blood-brain barrier should allow for clinical investigations into the targeted delivery of biologic agents such as antibodies for brain disorders.
  July 2014 ,Journal of the American College of Cardiology,Long Term Benefit of Early Metoprolol in AMI,Does early IV metoprolol before reperfusion result in fewer admissions due to heart failure?
  July 2014 ,Medicine and Science in Sports and Exercise,"Adiposity, Insufficient MVPA and Cardiometabolic Health","A new study takes a look at the connection between adiposity, physical activity and the risk of cardiometabolic abnormalities among adults."
  July 2014 ,BMC Musculoskeletal Disorders,Pathological Fracture and Healing of Unicameral Bone Cysts,Learn more on the prognostic factors for pathological fractures and healing of unicameral bone cysts.
  July 2014 ,Journal of Cardiovascular Electrophysiology,Stroke Risk and AF Ablation With Anticoagulant by ECG,Find out more about balancing the competing risks of stroke and bleeding in patients with atrial fibrillation treated with and without oral anticoagulants.
  July 2014 ,The American Journal of Gastroenterology,Consumer Use of Over-the-Counter PPIs in Patients With GERD,How closely should patients taking over-the-counter PPIs for GERD be monitored by their clinicians?
  July 2014 ,Southern Medical Journal,Risk Stratification in Acute Pulmonary Embolism,Does risk stratification--either by measurement of a biomarker or the performance of an echocardiogram-- improve outcomes in patients with acute pulmonary embolism?
  July 2014 ,International Journal of Clinical Practice,Drugs for Pain Associated With Postherpetic Neuralgia,"What pharmacological therapies are most effective for the treatment of neuropathic pain such as postherpetic neuralgia, MS-related pain, central poststroke pain, and HIV-related neuropathy?"
  July 2014 ,Pharmacogenomics,Pharmacogenetics of Second-Generation Antipsychotics,How does genetic variation influence individual response and side effect profiles for the commonly prescribed atypical antipsychotics?
  July 2014 ,AIDS,Adverse Events According to CD4 Count at the Start of ART,Are HIV patients who start ART with a higher CD4 count at greater risk of ART-related adverse events?
  July 2014 ,Personalized Medicine,Highlights From the Latest Articles in Suicide Research,"These studies evaluate the relationship of anger, gender differences, and bipolar disorder to suicide risk."
  July 2014 ,Cardiovascular Diabetology,Different ARBs and Incidence of Diabetes,Do these common antihypertensives increase risk for diabetes?
  July 2014 ,Neurosurgical Focus,Calculations in Spine Surgery Cost-Effectiveness Research,"This study systematically reviewed all cost-effectiveness studies published on spine surgery, comparing and contrasting various costing methodologies used."
  July 2014 ,BMC Anesthesiology,Intra-Aortic Balloon Pump During Extracorporeal Life Support,Does the use of an intra-aortic balloon pump during extracorporeal life support improve survival in patients with myocardial infarction and cardiogenic shock?
  July 2014 ,Spine,Comparison of 2 Lumbar Total Disc Replacements,How do these two lumbar total disc replacement devices compare in regard to safety and outcome?
  July 2014 ,Modern Pathology,Philadelphia Chromosome-Negative Myeloproliferative Neoplasms,This study tested the reproducibility of the histological parameters set out by the controversial WHO diagnostic classification for Philadelphia chromosome-negative myeloproliferative neoplasms.
  July 2014 ,Endocrine Practice,Managing Radioactive Iodine-Refractory Thyroid Cancer,Which novel targeted therapies are effective for advanced differentiated thyroid cancer?
  July 2014 ,Journal of Cardiovascular Electrophysiology,High-Risk Lead Removal by Laser Extraction and Thoracotomy,A new kind of hybrid procedure may be just right for pacemaker lead retrieval.
  July 2014 ,BMC Ophthalmology,Visual Outcome of Mega-dose IV Corticosteroids in NAION,Is treatment with IV corticosteroids a safe and effective means of improving visual outcome in NAION patients?
  July 2014 ,The American Journal of Gastroenterology,Poor Adherence to Guidelines for Chronic HBV Management,Does poor adherence to guidelines in the treatment and management of hepatitis B translate into poor patient outcomes?
  July 2014 ,Pacing and Clinical Electrophysiology,Survival in Octogenarians Undergoing CRT vs General Population,Do elderly heart failure patients with biventricular pacemakers live longer than their non-paced peers?
  July 2014 ,Southern Medical Journal,Hepatitis B in Pregnancy,"Each year, thousands of infants are born to women who are infected with the hepatitis B virus. How should the pregnant patient with HBV be managed?"
  July 2014 ,Personalized Medicine,Recent Advances in Personalized Lung Cancer Medicine,Learn about genotype-directed targeted therapy for NSCLC.
  July 2014 ,Cardiovascular Diabetology,Saxagliptin Improves Function of Pro-angiogenic Cells,Do DPP-4 inhibitors protect against cardiovascular disease? Read this to find out.
  July 2014 ,European Heart Journal,Left Atrial Structure and Function in Atrial Fibrillation,"Learn more about the complex relationship between left atrial structure and function, electrical burden of atrial fibrillation and stroke risk."
  July 2014 ,HIV Medicine,Pulmonary Abnormalities in HIV+ Patients Treated With ART,What are the risk factors for pulmonary abnormalities in HIV-positive patients?
  July 2014 ,BMC Psychiatry,The Use of Global Positional Satellite Location in Dementia,"Getting lost outside is an all-too common occurrence for people with dementia, and often results in institutionalization. Might providing dementia patients with a GPS tracker help?"
  July 2014 ,American Heart Journal,Adherence to Dabigatran and Longitudinal Outcomes,Find out more about adherence to dabigatran in the first year after initiation and the association between non-adherence to dabigatran and clinical outcomes.
  July 2014 ,Menopause,Health of Women Beginning Postmenopausal Hormone Therapy,What are some of the reasons why women would take hormone therapy after menopause? This new study explains.
  July 2014 ,Seminars in Respiratory and Critical Care Medicine,Rheumatoid Arthritis and Lung Disease: A Practical Approach,Common scenarios facing pulmonologists and rheumatologists are addressed using the current best evidence.
  July 2014 ,Alcohol and Alcoholism,Cannabis as a Substitute Medication for Alcohol?,This study sought to determine whether cannabis satisfies previously published criteria for substitute medications. Should it be prescribed to alcohol-dependent individuals to help reduce drinking?
  July 2014 ,Annals of Oncology,PCR After Neoadjuvant Chemo and Breast Cancer Subtypes,"What are the prognostic implications of pCR, TP53 status and treatment arm (taxane versus non-taxane) for intrinsic breast cancer subtypes?"
  July 2014 ,Journal of the American Geriatrics Society,Thiazide-Induced Metabolic Adverse Events in Older Adults,"Thiazide diuretics are associated with several potentially severe metabolic adverse events, especially in the elderly. What should you know before prescribing these agents to older adults?"
  July 2014 ,Liver International,A Pill for HCV -- Myth or Foreseeable Future?,"What all-oral, interferon-free therapies for hepatitis C are on the horizon?"
  July 2014 ,BMC Endocrine Disorders,Efficacy and Safety of Canagliflozin in Older Patients,Are SGLT2 inhibitors safe in patients older than 65 years?
  July 2014 ,The Journal of Emergency Medicine,Prednisone for Emergency Department Low Back Pain,The corticosteroid prednisone is commonly used to treat low back pain in the ED -- but how effective is it?
  July 2014 ,Journal of the International Association of Providers of AIDS Care,Retention in HIV Care in Year 1: Who's In and Who's Out?,Which patients are less likely to be retained in HIV care?
  July 2014 ,American Heart Journal,Antithrombotics in STEMI Patients Transferred for Primary PCI,Are patients with STEMI who are transferred for PCI at risk for delayed and/or excessively dosed antithrombotic therapy?
  July 2014 ,Diabetes Care,T1DM Through the Life Span: ADA Position Statement,"From preconception counseling to pancreas transplantation, this statement from the ADA guides type 1 diabetes management for all patients."
  July 2014 ,Current Opinion in Infectious Diseases,Novel Antibiotics for Skin and Soft Tissue Infection,Novel antibiotics are required because antibiotic resistance is a major global health hazard. This review examines recent antimicrobial developments.
  July 2014 ,Journal of Pediatric Health Care,Current Guidelines for Weight Loss Surgery in Adolescents,What are the current clinical practice guidelines for weight loss surgery in adolescents?
  July 2014 ,BMC Infectious Diseases,Probiotics for Pediatric Upper Respiratory Tract Infections?,"The role of probiotics in GI and allergic diseases has been largely assessed, but could probiotics be beneficial for pediatric respiratory infections as well?"
  July 2014 ,Current Opinion in Rheumatology,Infection Risk and Biologics: Current Update,What is the risk of infection for a patient being treated with biologics?
  July 2014 ,Liver International,Effect of Lifetime Alcohol Consumption on Severity of NAFLD,Does lifetime alcohol consumption predispose a patient to more severe forms of NAFLD? This new study explores the connection.
  July 2014 ,Journal of the American College of Cardiology,Classifications of Atrial Fibrillation and Temporal Persistence,Find out how atrial fibrillation classification can be improved and how it may impact treatment.
  July 2014 ,BMC Family Practice,Increasing Physical Activity by Organized Follow-Up,"Physical inactivity has been identified as the fourth leading risk factor for mortality, but getting patients to increase activity is challenging. Can a program of organized follow-up help?"
  July 2014 ,Clinical Endocrinology,Growth Hormone in Adults With Growth Hormone Deficiency,"What are the long-term effects of growth hormone therapy on risk of cardiovascular disease, fractures, cancer, and stroke?"
  July 2014 ,International Journal of Impotence Research,Reasons for Discontinuation of PDE-5 Inhibitors for ED,"Which ED patients are most likely to discontinue PDE5 therapy, and why? What can clinicians do to encourage compliance of this treatment?"
  July 2014 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,US Exam for Underlying Lesions During Physical Exam,"How well do medical students perform this ultrasound-assisted physical exam, and can it play a role in the primary care setting?"
  July 2014 ,Translational Lung Cancer Research,Immunotherapy in Lung Cancer,Immunotherapy has emerged in recent years as a promising therapeutic approach in lung cancer. Two approaches of particular interest are highlighted.
  July 2014 ,BMC Public Health,Bullying Among Severely Obese Adolescents,"Obese adolescents are especially prone to being bullied, both traditionally and, increasingly, with cyberbullying. What impact does this have on their psychological well-being and treatment efforts?"
  July 2014 ,Current Opinion in Gastroenterology,Therapy of IBD: What to Expect in the Next Decade,Read this new study to learn all about the exciting therapies on the horizon for the treatment of IBD.
  July 2014 ,European Heart Journal,The Atrial Fibrillation Ablation Pilot Study,Find out how centers evaluate the success of the procedure and evaluate long-term safety/complications.
  July 2014 ,Prostate Cancer and Prostatic Diseases,Novel Bone-Targeting Agents in Prostate Cancer,What are the newest bone-targeting agents for bone metastases in prostate cancer?
  July 2014 ,BMC Oral Health,ART and Fluoride-Releasing Sealants in Caries Prevention,"Dental sealants are widely accepted as highly effective in preventing dental caries, but which type does a better job?"
  July 2014 ,Nanomedicine,Delivery of Peptides for Anti-Tumor Immunotherapy,Could nanotechnology-based delivery of antigenic peptides be feasible for efficiently inducing anti-tumor cytotoxic T lymphocyte responses?
  July 2014 ,AIDS,Locomotor Functions Over Time in HIV-Infected Patients,How does motor function over time in HIV+ individuals compare with healthy individuals?
  July 2014 ,American Heart Journal,Alcohol Consumption and Systolic Ventricular Function,Does alcohol consumption impact LV systolic function?
  July 2014 ,Urologic Nursing,Urinalysis Collection and Results in Pelvic Organ Prolapse,Learn best practice methods for a clean catch specimen in patients with pelvic organ prolapse.
  July 2014 ,Current Opinion in Psychiatry,Polysubstance Use: Diagnostic Challenges and Patterns of Use,Individuals who abuse multiple substances are at elevated risk of developing comorbid psychiatric and other health conditions. Should they be approached differently than abusers of a single substance?
  July 2014 ,Annals of Oncology,Anthracyclines and Taxanes in Breast Cancer Treatment,Is it optimal to give taxane before the anthracycline in breast cancer treatment?
  July 2014 ,Future Oncology,Vintafolide: A Novel Targeted Epithelial Ovarian Cancer Agent,Get up-to-date on trial results for this novel folate receptor (FR)-targeted agent for epithelial ovarian cancer.
  July 2014 ,Skin Therapy Letter,Xerese for the Treatment of Herpes Labialis,"What you need to know about Xerese, a topical combination acyclovir-hydrocortisone product for treating herpes labialis, commonly known as cold sores. What other therapies have proven effective?"
  July 2014 ,Brain,Glucocerebrosidase Is Shaking Up the Synucleinopathies,"Recent progress in unraveling the mechanisms involving the enzyme glucocerebrosidase is not only advancing therapy for Gaucher disease, but may impact understanding of Parkinson's disease as well."
  July 2014 ,Neurosurgical Focus,Management of Traumatic Thoracolumbar Burst Fractures,What's the level of evidence for the use of conservative management in traumatic thoracolumbar burst fractures?
  July 2014 ,Oncology Nursing Forum,CBT for Insomnia After Primary Breast Cancer Treatment,Find out how nurse-delivered therapy impacts insomnia in women who have undergone breast cancer treatment.
  July 2014 ,Morbidity & Mortality Weekly Report,Use of MenACWY-CRM Vaccine in Children Aged 2-23 Months,"MenACWY-CRM, the first quadrivalent meningococcal conjugate vaccine, is an additional option for vaccinating infants aged 2-23 months at increased risk for meningococcal disease."
  July 2014 ,Nutrition and Metabolism,Systemic & Tumor Level Iron Regulation in Colorectal Cancer,How does hepcidin affect tumor iron accumulation in patients colorectal cancer?
  July 2014 ,Alimentary Pharmacology & Therapeutics,Therapy of Chronic Delta Hepatitis With Peginterferon Alfa,How well does peg-interferon work as a long-term treatment for chronic delta hepatitis?
  July 2014 ,HIV Medicine,Impact of Maternal HBV on Mother-to-Child HIV Transmission,Does maternal HBV/HIV coinfection increase the risk for perinatal HIV transmission?
  July 2014 ,BMC Public Health,HPV Vaccination in Sweden: School Nurses' Attitudes,"Sweden introduced a school-based HPV vaccination program in 2012, and school nurses are responsible for its administration. What have their experiences been?"
  July 2014 ,BMC Neurology,Social Participation in Patients With Multiple Sclerosis,"This study sought to determine the links between the economic costs related to treatment of multiple sclerosis and health state, quality of life, and improvements in social participation."
  July 2014 ,Nephrology Dialysis Transplantation,Glomerular Filtration Rate Estimation,Is it more accurate to estimate glomerular filtration rate using cystatin c alone or in combination with creatinine?
  July 2014 ,BMC Family Practice,Towards a Useful Diagnosis of Medically Unexplained Symptoms,This study explores the clinical usefulness of a proposed new diagnostic category for mild-to-moderate conditions of medically unexplained symptoms which the authors term 'multiple symptoms'.
  July 2014 ,Southern Medical Journal,Surge in US Vitamin D Deficiency Diagnoses: Commentary,"In this commentary, the author questions how the findings of the Huang study should impact clinical practice. Should screening for vitamin D deficiency be routine?"
  July 2014 ,The Pediatric Infectious Disease Journal,Motavizumab Treatment of Infants Hospitalized With RSV,Does treatment with motavizumab improve clinical outcomes for hospitalized infants with RSV?
  July 2014 ,European Heart Journal,Effect of BNP-Guided Treatment of Chronic HF on Mortality,"Natriuretic peptide-guided heart failure treatment has been tested in multiple studies, but findings have been limited -- until now."
  July 2014 ,Alimentary Pharmacology & Therapeutics,The Effects of Rifaximin in Hepatic Encephalopathy,"How well does rifaximin work in the management of hepatic encephalopathy, in terms of prevention as well as the treatment of acute episodes?"
  July 2014 ,Journal of Viral Hepatitis,Preventing Mortality in Patients With Cirrhosis and HCV,What is the number needed to treat in order to prevent mortality and complications in cirrhotic patients with HCV genotype 1?
  July 2014 ,BMC Oral Health,Survival of Restorations in Patients With Disability,Are ART restorations as durable as conventional restorations in patients with disability referred for special care dentistry?
  July 2014 ,BMC Family Practice,Use of Home Remedies by Patients in Germany,"How prevalent is the use of home remedies, and what are the conditions they are most commonly used for?"
  July 2014 ,Diabetes Care,Patient Preferences for Noninsulin Diabetes Medications,Learn what patients like and don't like about antidiabetes medications.
  July 2014 ,Endocrine Practice,Chronic CKD-MBDs: What the Endocrinologist Needs to Know,How should skeletal and metabolic disorders be managed in patients with CKD-MBDs?
  July 2014 ,European Heart Journal,Contrast-Induced Acute Kidney Injury After Primary PCI,What's the up-shot for contrast-induced acute kidney injury -- in terms of outcomes?
  July 2014 ,BMC Psychiatry,Adult ADHD and Nicotine Use,"Adults with ADHD show significantly higher rates of cigarette smoking than do members of the general population. Do they consider their smoking an attempt at self-medication, or a social behavior?"
  July 2014 ,Liver International,Hepatitis C Therapy in Elderly Patients,Are elderly patients with chronic hepatitis C likely to have a worse response to therapy than younger patients?
  July 2014 ,Menopause,Quality of Life in Women With or Without Hot Flashes,Does hormone therapy improve health-related quality of life in women who experience hot flashes?
  July 2014 ,Future Microbiology,Laboratory Diagnosis of Mucormycosis,"This article provides an overview on current laboratory methods for diagnosing potentially life-threatening mucormycosis, with a special focus on new molecular-based tools."
  July 2014 ,BMC Ophthalmology,The Prevalence of Anxiety and Depression in People With AMD,Are patients with AMD more likely to experience anxiety and depression compared to those without AMD? This review investigates.
  July 2014 ,BMC Dermatology,Measuring Acceptability of Treatment Response in Vitiligo,What constitutes a successful treatment response in vitiligo from the patient's perspective?
  July 2014 ,BMC Pregnancy and Childbirth,Transfer to Hospital in Planned Home Births,"How common are transfers from home to hospital during and after planned home births, and how can women and their clinicians prepare for this possibility?"
  July 2014 ,Schizophrenia Bulletin,A New Generation Cognitive Remediation Program,This study examined the efficacy of a novel neuropsychological rehabilitation program in improving negative symptoms and functional outcomes in schizophrenia.
  July 2014 ,Current Opinion in Neurology,Rare Primary Headaches,"A brief primer on the presentation, pathophysiology, and treatment options of rare headache disorders, including nummular and hypnic headaches and headache associated with cold, exercise, or sex."
  July 2014 ,Kidney International,KDIGO Clinical Practice Guideline for Lipid Management in CKD,What do the latest clinical practice guidelines say about the best approaches for lipid management in patients with CKD?
  July 2014 ,Cardiovascular Diabetology,Potential of Acarbose to Reduce Cardiovascular Disease,Can this agent treat diabetes and reduce cardiovascular risk to boot?
  August 2014 ,Neurosurgical Focus,Use of CT for Assessing Bone Mineral Density,"Find out about the utility of Hounsfield unit values in assessing fracture risk, implant stability, and spinal fusion success."
  August 2014 ,The Pediatric Infectious Disease Journal,Intussusception and Rotavirus Vaccines,The rotavirus vaccine comes with an increased risk of intussusception. Do the vaccination benefits still outweigh the risks?
  August 2014 ,Laboratory Investigation,Scrapings From Breast Tumors for Research Purposes,"This paper presents a simple method to generate material from small breast tumors, opening up new possibilities for tumor material for research purposes, biobanking, and next-generation sequencing."
  August 2014 ,European Heart Journal,Aliskiren and Antihypertensives in Elderly With Hypertension,Does BP lowering reduce cardiovascular disease in elderly individuals with SBP <160 mm Hg?
  August 2014 ,American Heart Journal,Delay in Reperfusion With Transradial PCI for STEMI,How much transradial PCI delay does it take to negatively impact mortality rates?
  August 2014 ,Europace,Novel Oral Anticoagulants in Cardiac Device Implantations,Compare the incidence of bleeding and thrombo-embolic complications following cardiac rhythm device implantations under dabigatran vs. rivaroxaban.
  August 2014 ,Rheumatology,Instruments Assessing Self-Efficacy in Rheumatic Diseases,This article reviews the six self-efficacy instruments available for patients with rheumatic diseases.
  August 2014 ,Nephrology Dialysis Transplantation,Hemoglobin Levels and Health-related Quality of Life,What is the best way to manage anemia in patients with CKD in order to reduce the risk of cardiovascular morbidity and mortality?
  August 2014 ,BMC Oral Health,Potential Oral Health Impact of Cost Barriers to Dental Care,How do financial barriers to care impact oral health? This study focused on the oral health status and dental treatment needs of Canadians who cannot afford dental care.
  August 2014 ,Southern Medical Journal,Tiotropium in the Treatment of Patients With Asthma,"Tiotropium, a long-acting anticholinergic agent used in patients with COPD, is showing encouraging results as an alternative treatment in patients with asthma."
  August 2014 ,Emerging Infectious Diseases,Outcomes of Streptococcus suis Infection in Humans,"Streptococcus suis is a bacterium that affects pigs, but can cause systemic disease in humans. What are the risk factors and outcomes?"
  August 2014 ,European Heart Journal,Catheter-Based Renal Denervation for Resistant Hypertension,Learn more about long-term results of renal artery denervation for treatment of treatment-resistant hypertension.
  August 2014 ,Current Opinion in Infectious Diseases,Avoiding Antibiotics in Skin Inflammation and Infection,What is the clinical value of antiseptics and antiseptic dressings for skin infection in this era of antimicrobial resistance?
  August 2014 ,Journal of Cardiovascular Electrophysiology,Decreased Inappropriate Shocks by Remote Monitoring of ICD,Find out more about automatic wireless remote monitoring of ICDs -- to reduce inappropriate shocks.
  August 2014 ,Journal of the American Geriatrics Society,Determining Normal Cognitive Function vs. MCI in Older Adults,This study examined whether pre-clinical disability in performance of cognitively focused ADL tasks can discriminate between older adults with normal cognitive function and those with MCI.
  August 2014 ,BMC Psychiatry,Comorbid Type 1 Diabetes and Eating Disorders,"Patients with T1DM are at risk of developing eating disorders, particularly bulimia. Do motivations and treatment outcomes differ between individuals with eating disorders and T1DM, and those without?"
  August 2014 ,BMC Clinical Pathology,Testing by Hematopathology Specialty and Other Laboratories,Successful management of patients with hematologic malignancies depends upon early and accurate diagnosis. Does a specialized hematopathology lab do better than a traditional lab?
  August 2014 ,Neurosurgical Focus,Bracing for Thoracolumbar Fractures,"Find out more about bracing, a low-risk, cost-effective method to treat certain thoracolumbar fractures, equivalent to that of surgical management in many cases."
  August 2014 ,American Journal of Clinical Dermatology,Diabetic Foot Ulcer: An Evidence-Based Treatment Update,Potentially life-threatening diabetic foot ulcers can be extremely challenging to treat. This review presents the latest evidence-based research on a wide range of treatment modalities.
  July 2014 ,Translational Lung Cancer Research,Lung Cancer Vaccines: Current Status and Future Prospects,Find out how a greater understanding of the immune system and tumor antigens has led to advances in the use of immunotherapy -- including vaccines to target lung cancer.
  August 2014 ,Diabetes Care,Statins and the Risk of Diabetes,A potential downside of adherence? Read how statin use may increase risk of diabetes.
  August 2014 ,BMC Infectious Diseases,Efficacy of Surface Disinfectants Against Resistant Bacteria,How effective are surface disinfectant cleaners against multi-drug resistant bacteria?
  August 2014 ,American Heart Journal,Adipose-Derived Regenerative Cells in Ischemic Cardiomyopathy,Can liposuction-leavings help patients with ischemic cardiomyopathy?
  August 2014 ,Clinical Endocrinology,Diagnosis and Management of Gastric Neuroendocrine Neoplasms,Gastric neuroendocrine neoplasms are not associated with any specific symptoms. When should you be suspicious?
  August 2014 ,The American Journal of Gastroenterology,Fecal Transplant for C Diff in Immunocompromised Patients,Is fecal transplant a successful and safe treatment for immunocompromised patients with C. difficile infection? This new study looks at the latest research.
  August 2014 ,European Heart Journal,Totally Subcutaneous Implantable Defibrillator,Does the new alternative to conventional transvenous ICD systems minimize complications such as inappropriate shocks?
  August 2014 ,Medicine and Science in Sports and Exercise,Cut Points of Muscle Strength Linked to Metabolic Syndrome,At which threshold of muscle strength does the risk for metabolic syndrome increase? A new study investigates the issue in men.
  August 2014 ,Menopause,Women's Health Initiative Calcium/Vitamin D Randomized Trial,"Are increased serum 25-hydroxyvitamin D concentrations, in response to calcium/vitamin D supplementation, associated with an improved lipid profile in postmenopausal women?"
  August 2014 ,American Heart Journal,Chelation With Multivitamins for Coronary Disease,"In stable post-MI patients on evidence-based medical therapy, how does the combination of oral high-dose vitamins and chelation therapy compare with double placebo -- for impact on cardiovascular events?"
  August 2014 ,AIDS,Drug Resistance Among Newly Diagnosed HIV-Infected Children,How should drug resistance in HIV-infected infants and young children be managed?
  August 2014 ,Pediatric Critical Care Medicine,Time for a Neonatal-Specific Consensus Definition for Sepsis,How has sepsis been defined in neonates and is it dynamic enough?
  August 2014 ,Journal of the American College of Cardiology,Practice Guidelines for the Management of LDL-Related Risk,Managing risk related to LDL is vital for patients at risk for atherosclerotic cardiovascular disease events -- given its role in atherogenesis.
  August 2014 ,Current Orthopaedic Practice,Surgical and Anatomic Considerations in ACL Reconstruction,What's the latest in ACL reconstruction surgery? This article will bring you up to date.
  August 2014 ,Applied Radiology,Basics of Diffusion and Perfusion Imaging in Brain Tumors,"This article presents the basic principles of perfusion and diffusion MRI imaging of the brain, providing clinical examples of their application in predicting brain tumor type and grade."
  August 2014 ,Diabetes,Diabetes and Cardiovascular Disease in Older Adults,Why are the aging heart and vessels vulnerable to diabetes?
  August 2014 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Adherence Pattern to a Daily Oral Pre-exposure Prophylaxis,"What factors are associated with good adherence to daily, oral HIV pre-exposure prophylaxis?"
  August 2014 ,Future Neurology,New Imaging Techniques Reveal Metabolism of the Aging Brain,Brain metabolism is an important biomarker for aging and neurodegenerative disorders. What can the latest neuroimaging techniques tell us about the aging brain?
  August 2014 ,Clinical Lipidology,Novel Anti-obesity Drugs and Plasma Lipids,Can 'one pill make you smaller' yet?
  August 2014 ,Liver International,Efficacy of Nitazoxanide in the Treatment of HCV Genotype 4,"What does the latest research tell us about the efficacy of nitazoxanide, pegylated interferon, and ribavirin in combination for the treatment of genotype 4 chronic hepatitis C?"
  August 2014 ,Human Reproduction,Combination Treatment for Non-tubal Ectopic Pregnancies,"Is combination gefitinib and methotrexate therapy a safe and effective treatment for non-tubal ectopic pregnancies, and does it resolve the pregnancies without the need for surgery?"
  August 2014 ,The American Journal of Gastroenterology,A Personalized Medicine Approach to the Management of IBD,How can clinicians apply the therapeutic principles of personalized medicine to the medical management of patients with inflammatory bowel disease?
  August 2014 ,American Journal of Clinical Pathology,Endometrial Hyperplasia in Epithelial Ovarian Cancer,How prevalent are endometrial premalignancies in women diagnosed with epithelial ovarian cancer?
  August 2014 ,Newborn & Infant Nursing Reviews,Therapeutic Hypothermia for Neonatal Encephalopathy,Nurses play a large role in the identification and care of infants receiving therapeutic hypothermia.
  August 2014 ,Current Opinion in Gastroenterology,Steroids vs Dietary Therapy to Treat Eosinophilic Esophagitis,Are steroids more effective than dietary therapy in the treatment of eosinophilic esophagitis? This new study investigates.
  August 2014 ,American Heart Journal,Trends in Pharmacologic Management of Atrial Fibrillation,Learn more about patients with new AF episodes who were prescribed oral rate or rhythm control medications.
  August 2014 ,Current Opinion in Infectious Diseases,Skin Antisepsis in the Neonate: What Should We Use?,What are the most effective yet safest topical antiseptics for use in neonates to reduce nosocomial sepsis?
  August 2014 ,AIDS,Nonoccupational Postexposure Prophylaxis for HIV Prevention,There have been many challenges with the implementation of HIV nonoccupational postexposure prophylaxis. What new solutions are on the horizon?
  August 2014 ,U.S. Pharmacist,Cardiovascular Risk With NSAIDs and COX-2 Inhibitors,Which NSAID is the safest in patients with high cardiovascular risk?
  August 2014 ,HIV Medicine,Once-Daily MVC plus DRV/r in Pretreated HIV Patients,This study assesses the efficacy and safety of MVC plus DRV/r once-daily in HIV-infected pretreated patients.
  August 2014 ,Applied Radiology,MRI in Abdominopelvic Emergencies,"MRI can be a useful alternative to CT in abdominopelvic emergencies. When is it most appropriate, and when is it contraindicated?"
  August 2014 ,Endocrine Practice,AACE/ACE Consensus Statement on Insulin Pump Management,"Learn everything there is to know about insulin pumps... Like how and when to use them, and which patients would benefit most."
  August 2014 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Epidemiology of SIRS in the Emergency Department,Gain a better understanding of the epidemiology of SIRS among adult ED patients.
  August 2014 ,Nutrition and Metabolism,Obesity & 25-Hydroxyvitamin D Deficiency in Cerebral Palsy,Is there an association between vitamin D deficiency and obesity in patients with cerebral palsy?
  August 2014 ,Age and Ageing,Acute Coronary Syndrome Management in Older Adults,"Management of acute coronary syndrome in older adults remains a clinical challenge, despite existing guidelines. What are the reasons for age-dependent inequalities in care?"
  August 2014 ,Wounds,Sural Fasciocutaneous Flap for Knee and Lower Leg Defects,Learn more about clinical outcomes of using a sural fasciocutaneous island flap for reconstruction of traumatic soft-tissue defects around the knee and on the proximal lower leg.
  August 2014 ,Journal of Viral Hepatitis,Relapse Rates in Chronic HBV After Stopping Antivirals,How can clinicians prevent relapse in patients with chronic hepatitis B after discontinuation with antiviral therapy?
  August 2014 ,Nursing Economics,Group Visits for Chronic Illness Management,Group visits are increasingly being used as a substitute for individual patient visits in a wide variety of settings and for diverse patient populations. Find out why.
  August 2014 ,Seminars in Respiratory and Critical Care Medicine,Sarcoidosis: Recent Advances,Find out about the scientific and clinical progress of the past 4 years -- in sarcoidosis management.
  August 2014 ,Alimentary Pharmacology & Therapeutics,The Epidemiology and Prevention of Gastric Cancer,"How does gastric cancer develop, what are some of the potential causes, and how can it be prevented?"
  August 2014 ,The Pediatric Infectious Disease Journal,Antibiotic Utilization in Pediatric Soft Tissue Infections,Children hospitalized for soft tissue infection are often prescribed broad spectrum antibiotics. Is there an opportunity to reduce the antibiotic use in these patients?
  August 2014 ,HIV Medicine,Raltegravir in Virologically Suppressed Overweight Women,"When women with central adiposity switch to RAL from a PI or NNRTI, they could experience a significant decrease in sCD14."
  August 2014 ,AIDS,Pre-exposure Prophylaxis and Contraception Effectiveness,How effective are hormonal contraceptives for pregnancy prevention in women taking HIV pre-exposure prophylaxis?
  August 2014 ,American Heart Journal,Early Termination of Cardiovascular Trials Due to  Recruitment,Is there a common thread between terminated trials?
  August 2014 ,Interventional Cardiology,"Renal Sympathetic Denervation: Indications, Contemporary Devices",Learn more about the utility of renal denervation and emerging devices along with issues to be addressed before renal denervation becomes mainstream therapy.
  August 2014 ,Malaria Journal,Acceptance of a Malaria Vaccine by Caregivers in Kenya,Several malaria vaccines are currently in clinical trials and are expected to improve malaria control world-wide. Will the countries that need it most accept this practice?
  August 2014 ,Future Oncology,Ofatumumab as Front-Line Therapy in Untreated CLL,Find out about the efficacy and toxicities of ofatumumab alone and in combination for the front-line treatment of CLL.
  August 2014 ,OJIN: The Online Journal of Issues in Nursing,The Affordable Care Act: Primary Care and the DNP,Learn how the ACA serves as a model for prevention and the role of DNP nurses as primary care providers.
  August 2014 ,BMC Public Health,Engaging T2DM Patients in Their Own Health Management,Engaging patients in their care is a crucial issue in the treatment and management of type 2 diabetes. What factors might contribute to fostering--or hindering--patient engagement?
  August 2014 ,Spine,Nonoperative Management of Discogenic Back Pain,Find out about various non-surgical options for treating discogenic back pain.
  August 2014 ,American Journal of Pharmaceutical Education,Effectiveness of E-learning in Pharmacy Education,"E-learning may increase knowledge in the short-term, but how about the long-term?"
  August 2014 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Yield and Predictors of Thoracic Spine Injury From Chest CT,How useful is chest CT in evaluating blunt trauma patients for thoracic spine injuries?
  August 2014 ,The Pediatric Infectious Disease Journal,Escherichia coli Bacteremia in Children,Examining the age and portal of entry could help predict severity of E. coli bacteremia in children.
  August 2014 ,The British Journal of Dermatology,Omalizumab for Chronic Idiopathic or Spontaneous Urticaria,Could the recombinant humanized anti-IgE monoclonal antibody omalizumab be effective for improving symptoms in patients with chronic idiopathic urticaria?
  August 2014 ,Headache,Treatment Persistence and Switching in Triptan Users,Triptans can be a valuable option for acute treatment of migraine. So why is treatment persistence with triptans so low?
  August 2014 ,BMC Oral Health,Dental Plaque Bacteria Susceptibility to Triclosan,Triclosan is a broad-spectrum antimicrobial agent used in toothpastes and mouthwashes. Does susceptibility to triclosan decline over time?
  August 2014 ,Critical Care Medicine,Door-to-Balloon Time Not Most Critical Factor in STEMI Outcome,A new metric for STEMI patients may be on the near horizon. Find out more.
  August 2014 ,Clinical Endocrinology,Gonadotropins for Male Hypogonadotrophic Hypogonadism,How does testosterone compare with gonadotropin treatment for improving quality of life in hypogonadism?
  August 2014 ,Chinese Clinical Oncology,New Challenge of Developing Combined Radio-Drug Therapy,Find out more about development of combined modality treatments that can be used to improve control of local disease without increased toxicity.
  August 2014 ,BMC Pregnancy and Childbirth,Post-traumatic Stress Symptoms Following Childbirth,Does mode of delivery determine whether a woman will experience post-traumatic stress symptoms after giving birth?
  August 2014 ,The Journal of Invasive Cardiology,Comparison of Resource Utilization of Pulmonary Vein Isolation,Find out about the first US multicenter examination to report the procedural comparisons between cryoballoon and focal RF catheters used for treatment of PAF.
  September 2014 ,Rheumatology,Type I Interferon Blockade in Systemic Lupus Erythematosus,IFN-blocking strategies for the treatment of SLE are currently being evaluated in clinical trials. Are the results looking promising?
  September 2014 ,Skin Therapy Letter,Sirolimus: A Therapeutic Advance for Dermatologic Disease,"Originally approved as an immunosuppressant in transplant recipients, the mTOR inhibitor sirolimus is proving to have a multitude of applications in dermatologic diseases and as an anti-aging agent."
  September 2014 ,Journal of the National Cancer Institute,CTCs and Survival in Breast Cancer Patients,Find out how the SUCCESS trial provides strong evidence for the prognostic relevance of CTCs in early breast cancer before and after adjuvant chemotherapy.
  September 2014 ,BMC Psychiatry,Predictors of PTSD Symptoms Following Childbirth,Posttraumatic stress disorder following childbirth is increasingly being recognized. Can factors be determined to help predict its occurrence?
  September 2014 ,European Heart Journal,Reperfusion Therapy for ST Elevation Acute Myocardial Infarction,Take a contemporary look at how use and type of reperfusion therapy vary in patients admitted with STEMI.
  September 2014 ,Current Opinion in Infectious Diseases,Managing Infections in Pregnancy,Viral and parasitic infections in pregnancy may affect fetal development. How should these infections be managed?
  September 2014 ,American Journal of Clinical Dermatology,A Practical Approach to Cutaneous Small-Vessel Vasculitis,"The article presents a comprehensive overview of cutaneous small-vessel vasculitis, with a practical guide to its clinical features, etiology, laboratory evaluation, and management."
  September 2014 ,AIDS,Is Bone Loss Linked to Chronic Inflammation in HIV?,What role do inflammation and vitamin D play in HIV bone loss?
  September 2014 ,American Heart Journal,Agreement on Outcome in a Cardiovascular RCT,Learn more about agreement between randomized trial outcome assessment by committee vs outcomes entirely identified through public registers.
  September 2014 ,Seminars in Neurology,Frontotemporal Lobar Degeneration: A Clinical Approach,"This review outlines a clinical approach to frontotemporal lobar degeneration, from epidemiology to diagnostic criteria and current and prospective treatments."
  August 2014 ,Annals of Clinical Microbiology and Antimicrobials,Multidrug-Resistant K. pneumoniae Isolates,This study investigated the molecular characterization of multi-drug resistant K. pneumoniae isolated from a variety of clinical samples of hospitalized patients.
  August 2014 ,BMC Ophthalmology,The Risk of Cataract in Type 2 Diabetes,Are patients with type 2 diabetes at a higher risk of developing cataracts? A new meta-analysis investigates the issue.
  August 2014 ,Influenza and Other Respiratory Viruses,Clinical Severity of Rhinovirus/Enterovirus in Children,How does the severity of rhinovirus/enterovirus compare to the severity of influenza or RSV in children?
  August 2014 ,BMC Public Health,Hepatitis C Screening Among Young People Who Inject Drugs,"Injection-drug users are at high risk for hepatitis C infection, yet many remain unaware of their infection status. Might the rapid HCV test encourage drug abusers to be screened?"
  August 2014 ,Nutrition and Metabolism,"Prehypertension, Adiponectin, and Insulinemia in Obesity",Why does obesity lead to sodium retention and increased blood pressure?
  August 2014 ,Diabetes Care,Psychological Distress and Incidence of Type 2 Diabetes,Do depression and anxiety increase the risk for diabetes?
  August 2014 ,Headache,Evaluation and Treatment of Migraine in the ED,Acute migraine is a common reason for emergency department visits. This review offers practical guidance on how patients with suspected migraine should be evaluated and managed in the ED setting.
  August 2014 ,Current Opinion in Pulmonary Medicine,Pulmonary Hypertension With COLD and Pulmonary Fibrosis,Learn more about how severe pulmonary hypertension worsens the prognosis of patients with COPD or idiopathic pulmonary fibrosis.
  August 2014 ,American Journal of Cardiovascular Drugs,Agents for Atrial Fibrillation Prevention After Cardioversion,"The acute success rate with electrical cardioversion is high, but relapse happens. Find out how to beat the odds of AF recurrence."
  August 2014 ,International Journal of Clinical Rheumatology,Variability in Response to Rituximab in Autoimmune Diseases,This article describes the variability in clinical response to rituximab in the treatment of rheumatoid arthritis and systemic lupus erythematosus.
  September 2014 ,Journal of the National Cancer Institute,MRI-Guided Ultrasound for Painful Bone Metastases,Learn more about the safety and efficacy of this noninvasive method of thermal tissue ablation for palliation of pain due to bone metastases.
  September 2014 ,BMC Anesthesiology,Intubating Conditions and Side Effects of Intubation Drugs,Which combination of drugs used for intubation produce more acceptable intubating conditions?
  September 2014 ,The American Journal of Gastroenterology,Genetic Evaluation and Management of Lynch Syndrome,What do the latest guidelines say about genetic testing for and management of Lynch syndrome?
  September 2014 ,Brain,Early Identification of 'Acute-Onset' Chronic IDP,The authors identify changes in nerve excitability parameters that can distinguish acute-onset chronic inflammatory demyelinating polyneuropathy from acute IDP at the earliest stages.
  September 2014 ,Nanomedicine,Interview With Donald E Ingber,"Donald E. Ingber, Founding Director of Harvard's Wyss Institute for Biologically Inspired Engineering, recounts his career in bioengineering and recent work in nanomedicine and cancer therapeutics."
  September 2014 ,Interventional Cardiology,Interventional Radiology - Current and Future,"Today it's amazing, but the future for interventional radiology may be even brighter . . ."
  September 2014 ,Journal of the American College of Cardiology,Transition From Blinded Study Drug to Open-Label,Learn about an end-of-trial transition plan to minimize bleeding and stroke risks during a critical period.
  September 2014 ,Liver International,Treatment of Chronic Hepatitis C Virus Infection,What are some of the remaining barriers to effective hepatitis C treatment in the United States?
  September 2014 ,BMC Clinical Pathology,Serum TFF3 and Response to Chemotherapy in GI Cancers,"This study investigated the feasibility of protein serum trefoil factor 3 as a biomarker for gastrointestinal cancer, as well as a pharmacodynamic predictor of response to chemotherapy."
  September 2014 ,Future Oncology,Targeted Therapies in Advanced Renal Cell Carcinoma,Are metastatic sites associated with survival in patients with renal cell carcinoma treated with targeted therapies?
  September 2014 ,American Journal of Pharmaceutical Education,Cost Savings Associated With Pharmacy Student Interventions,Student identification of potential allergic reactions and drug interactions can save health care dollars.
  September 2014 ,Wounds,Radiation Dermatitis Evidence From a Clinical Practice Guideline,Patients undergoing external radiation therapy to treat cancer often experience acute radiation dermatitis. These evidence-based guidelines provide prevention and treatment recommendations.
  September 2014 ,Preventing Chronic Disease,A Strength Training Program for Primary Care Patients,Strength training can be a powerful intervention for improving the health of older adults. How can primary care physicians best expand access to strength training for their patients?
  September 2014 ,Future Virology,Strategies to Eliminate HBV Infection,What novel strategies are being used to achieve sustained cure or elimination of HBV?
  September 2014 ,The British Journal of Dermatology,Methotrexate and Liver Fibrosis in People With Psoriasis,Does methotrexate actually increase the risk of liver fibrosis/cirrhosis in people with psoriasis or is this just an association?
  September 2014 ,Headache,Spreading Depolarization May Link Migraine and Stroke,Does enhanced susceptibility to spreading depolarization explain the underlying  mechanism of the migraine-stroke association?
  September 2014 ,Alimentary Pharmacology & Therapeutics,"Why, When, and How to De-escalate Therapy in IBD",How do clinicians know when to safely start tapering drug therapies in patients with different inflammatory bowel diseases?
  September 2014 ,BMC Endocrine Disorders,ICU Glucose Control: Space GlucoseControl System,This device can help control glucose in critically ill patients.
  September 2014 ,Nephrology Dialysis Transplantation,CKD-Renal Epidemiology and Information Network Cohort Study,What does the latest research tell us about the factors associated with CKD progression and its transition to ESRD?
  September 2014 ,BMC Oral Health,Self-Induced Vomiting and Dental Erosion -- A Clinical Study,"Dentists may be the first to spot this common, but often unrecognized, complication of bulimic eating disorders."
  September 2014 ,Journal of the National Cancer Institute,Lifestyle and Cancer-Associated DNA Change in the Colon,"Aberrant DNA methylation in gene promoters is associated with aging and cancer, but the circumstances determining methylation change are unknown."
  September 2014 ,Annals of Family Medicine,CVD Risk Among Women With Prior Pregnancy Loss,Is a history of miscarriage or stillbirth an independent risk factor for incident coronary artery disease in postmenopausal women?
  September 2014 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Effectiveness of Once-Daily ART vs a Triple-Tablet Regimen,"Switching from a once-daily, single tablet ART regimen to a triple-tablet regimen may result in drug cost savings, but are there other risks involved?"
  September 2014 ,Journal of the American College of Cardiology,High-Risk Plaque on CCTA Predicts ACS in Acute Chest Pain,"Find out how CTA in the ED, can fine tune diagnostic certainty of acute coronary syndromes -- in patients with acute chest pain but no objective evidence of MI."
  September 2014 ,Annals of Oncology,ABVD vs BEACOPP for Hodgkin's Lymphoma,Is the extra intensive regimen more efficacious for Hodgkin's Lymphoma -- even for low-risk patients?
  September 2014 ,Pediatric Pharmacotherapy,Use of Atropine in Infants and Children,The role of atropine continues to evolve in pediatric medicine. What should it be used for and how safe is it for this patient population?
  September 2014 ,Journal of Viral Hepatitis,Infection in Patients With Chronic Hepatitis C,What factors could be associated with the development of infection in patients with chronic HCV undergoing antiviral treatment?
  September 2014 ,Pharmacogenomics,Parkinson's Disease Pharmacogenomics: New Findings,Can variability in drug response and in complication occurrence with pharmacologic therapies for Parkinson's disease be explained by genetic factors?
  September 2014 ,Current Orthopaedic Practice,Pediatric ACL: Evaluation and Management,What are the best ways to manage ACL injuries in children?
  September 2014 ,Wounds,Urinary Bladder Matrix in Complicated Open Wounds,Which patients with complicated open wounds are best suited for urinary bladder matrix management?
  September 2014 ,BMC Endocrine Disorders,Diabetes Education Targeted to Racial/Ethnic Minority Groups,Educational programs targeted to minority groups demonstrate a positive effect on diabetes knowledge.
  September 2014 ,European Heart Journal,Ticagrelor vs Clopidogrel in Non-ST-Elevation ACS,"In patients with NSTE-ACS, is there a benefit of ticagrelor over clopidogrel for reducing ischemic events and total mortality?"
  September 2014 ,Personalized Medicine,Leflunomide Dosing in Rheumatoid Arthritis Patients,Can pharmacogenomics improve response to leflunomide?
  September 2014 ,Diabetes Care,Osteopontin in Patients With T1DM and Complications,Learn about a protein that can predict a first-ever cardiovascular event and nephropathy in T1DM.
  September 2014 ,Diabetes,Progression of Early Retinal Dysfunction in Diabetes,Does retinal progression in diabetic patients represent early signs of neurodegeneration?
  September 2014 ,Menopause,Product Labeling for Low-dose Vaginal Estrogen,"What should women know before taking low-dose estrogen, and what types of warnings should be present on drug labels? This new article discusses."
  September 2014 ,BMC Musculoskeletal Disorders,"Activity Levels, Physical Activity Participation After TKA","In this study, the authors evaluate physical activity levels in Korean patients both before and after undergoing TKA."
  September 2014 ,Clinical Lipidology,Role of Nutrition and Nutritional Supplements in Dyslipidemia,What should you recommend for patients with dyslipidemia -- who don't want to take statins?
  September 2014 ,The Pediatric Infectious Disease Journal,Late-onset Bloodstream Infections in Hospitalized Infants,What are the risk factors for late-onset bloodstream infections in hospitalized term infants?
  September 2014 ,Human Reproduction,Preserving Ovarian Reserve During Ovarian Cystectomy,What does the latest research tell us about the efficacy of a hemostatic sealant in preserving ovarian reserve in patients undergoing laparoscopic ovarian cystectomy?
  September 2014 ,Newborn & Infant Nursing Reviews,Challenges of Minimizing Heat Loss at Birth,What are the biggest obstacles to overcome in keeping neonates at an optimal temperature?
  September 2014 ,Cancer Control: Journal of the Moffitt Cancer Center,Kyphoplasty and Vertebroplasty in Malignant Vertebral Fractures,Learn more about how kyphoplasty and vertebroplasty are being successfully employed in the treatment of pathological vertebral fractures.
  September 2014 ,Liver International,Use of Protease Inhibitors in HIV/HCV Genotype 1 Coinfection,Guidelines on the use of first-generation HCV protease inhibitors in the treatment of coinfected patients are presented.
  September 2014 ,Critical Care,High Dose Tigecycline in Severe Infections,The high incidence of multidrug-resistant bacteria among patients admitted to ICUs has determined an increase of tigecycline use for the treatment of severe infections.
  September 2014 ,Chinese Clinical Oncology,The Changing World of Oncology Drug Development,Read about the emerging trend of 'basket' studies and opportunities for 'open innovation' developed in response to the increasing understanding of the genetic makeup of cancers.
  September 2014 ,Breast Cancer Research,HER2 in Trastuzumab/Emtansine vs Trastuzumab/Docetaxel,What group of patients experience enhanced improvement from T-DM1 therapy?
  September 2014 ,Future Oncology,Immunotherapy in Pediatric Malignancies,Find out what immunotherapies are being tested and glimpse the future of immuno-oncology for childhood cancer.
  September 2014 ,Environmental Health Perspectives,Time After Time: Environmental Influences on the Aging Brain,A growing body of evidence suggests environmental factors play an instrumental role in influencing neurological function in older adults--even exposures that occurred much earlier in life.
  September 2014 ,European Heart Journal,Titin Gene Mutations and Cardiomyopathies,Learn more about peripartum cardiomyopathy and familial dilated cardiomyopathy in women.
  September 2014 ,OJIN: The Online Journal of Issues in Nursing,Child Maltreatment: Overview and Prevention Considerations,Learn more about the health consequences of mistreating kids.
  September 2014 ,Cardiovascular Ultrasound,Integrated Natriuretic Peptide and Echo-Guided HF Management,"This review explores the utility of natriuretic peptides as biomarkers in heart failure, and outlines the potential of a cardiovascular ultrasound-based approach for personalized treatment."
  September 2014 ,Infection Control and Hospital Epidemiology,Preventing the Transmission of Multidrug-Resistant Organisms,"We all know that hand hygiene and environmental cleaning can reduce the spread of infection, but how much of an impact do they have on the prevention of multi-drug resistant organisms?"
  September 2014 ,BMC Endocrine Disorders,Obesity and Impaired Fasting Glucose Depending on GGT Levels,New research finds that serum GGT may have a role in the pathogenesis of impaired fasting glucose.
  September 2014 ,Spine,Incidence and Cost of Treating Axis Fractures in the U.S.,What is the incidence rate of C2 fractures and the cost of treating these injuries? This new study takes a look at the recent numbers.
  September 2014 ,Personalized Medicine,Will Genomic Medicine Be Useful for Patient Care?,What are the pros and cons of genomic medicine when taking care of patients?
  September 2014 ,Clinical Endocrinology,SFRP5 Correlates With Obesity and Metabolic Syndrome,Can this anti-inflammatory adipokine predict metabolic syndrome in children?
  September 2014 ,Nephrology Dialysis Transplantation,HDL Cholesterol and CVD Mortality in Hemodialysis Patients,Does elevated HDL cholesterol lower the risk of cardiovascular mortality in maintenance hemodialysis patients? This new study explores the connection.
  September 2014 ,Rheumatology,Biologic Therapies and Pregnancy: The Story So Far,Which biologic therapies used to treat arthritis are safest during pregnancy and breastfeeding?
  September 2014 ,Current Opinion in Gastroenterology,Wireless Capsule Endoscopy of the Small Intestine,Capsule endoscopy has progressed from a diagnostic test to a therapy within the small bowel. Which gastrointestinal conditions is it best used for?
  September 2014 ,BMC Psychiatry,DBS for Treatment-Refractory Obsessive Compulsive Disorder,"This review explores the use of deep brain stimulation for treating refractory OCD, with a focus on identifying specific brain structures for targeting."
  September 2014 ,BMC Pulmonary Medicine,Inflammatory Cytokine Response to Exercise in COPD Patients,Do alpha-1-antitrypsin-deficient (AATD) COPD patients exhibit reduced inflammation compared to non-AATD COPD patients?
  September 2014 ,Pediatric Pharmacotherapy,New Drug and Drug Formulation Approvals for Children,A wide variety of new drugs have recently been approved by the FDA that may be of benefit to children.
  September 2014 ,Annals of Oncology,New Agents for Prostate Cancer,Learn how the therapeutic landscape of metastatic castration-resistant prostate cancer has been revolutionized.
  September 2014 ,Pediatric Nursing,Maternal BMI and Control of Diabetes in Young Patients,Does a mom's size have an impact on how her children manage with diabetes?
  September 2014 ,Current Opinion in Allergy and Clinical Immunology,New Directions in Diagnostic Evaluation of Insect Allergy,Diagnosis of insect sting allergy and prediction of risk of anaphylaxis are often difficult because tests for venom-specific IgE antibodies have a limited positive predictive value.
  September 2014 ,Respiratory Research,Tiotropium Might Improve Survival in Subjects With COPD,"We know inhaled therapies reduce the risk of COPD exacerbations, but can they keep high risk patients alive longer as well?"
  September 2014 ,Personalized Medicine,Improving the Quality of Personalized Medicine,How are ethics linked to personalized medicine?
  September 2014 ,Alimentary Pharmacology & Therapeutics,Weekly Adalimumab Dosing in Ulcerative Colitis,Is an escalation to weekly dosage of adalimumab beneficial for patients with ulcerative colitis who have lost response to therapy or even for those who are not responding to induction therapy?
  September 2014 ,Medicine and Science in Sports and Exercise,Exercise During Chemotherapy and Breast Cancer Outcomes,"Initiating an exercise intervention during adjuvant chemotherapy may positively impact breast cancer outcomes, a new study suggests."
" Open Access Journal of Plastic Surgery,  September 2014 ",ePlasty,Cryolipolysis in Aesthetic Plastic Surgery,What is cryolipolysis? Find out how this procedure can be an effective option for selective fat reduction.
  September 2014 ,Menopause,Risk of Long-term Hot Flashes After Natural Menopause,"Are some women at risk for developing long-term hot flashes after natural menopause and, if so, why?"
  September 2014 ,Annals of Surgery,Laser Resurfacing and Remodeling of Hypertrophic Burn Scars,How effective are laser therapies for burn scar treatment?
  September 2014 ,Modern Pathology,Cribriform Adenocarcinoma of the Lung,"Cribriform adenocarcinomas of the lung represent a distinctive histologic subtype of lung cancer, and may be difficult to distinguish from metastatic lung neoplasms. How should they be approached?"
  September 2014 ,BMC Clinical Pathology,Biomarker Expression in Pancreatico-Biliary Adenocarcinomas,This study investigated the utility of four candidate biomarkers for the immunohistochemical characterization of pancreatico-biliary adenocarcinomas.
  September 2014 ,Clinical Endocrinology,Weight of Infants Born to Women With Gestational Diabetes,How does maternal gestational diabetes affect weight gain in infants?
  September 2014 ,The Pediatric Infectious Disease Journal,Clinical Characteristics of C. difficile in Children,The incidence of C. diff infection has been rising in hospitalized children. What are the risk factors for severe disease?
  September 2014 ,Current Opinion in Infectious Diseases,Antimicrobial Stewardship: Another Focus for Patient Safety?,"As antibiotic resistance continues to emerge, clinician must recognize that antimicrobial stewardship is an important part of patient safety."
  September 2014 ,International Journal of Clinical Practice,Tadalafil Once Daily for Erectile Dysfunction,High discontinuation rates of over 50% have been reported for short-acting PDE5-inhibitors used on-demand. Can a once-daily regimen of tadalafil improve adherence and patient satisfaction?
  September 2014 ,Cardiovascular Diabetology,Endothelial Progenitor Cells in AMI Patients With Diabetes,New research evaluates endothelial progenitor cells in patients with heart disease and diabetes.
  September 2014 ,Interventional Cardiology,Mobile Health Applications in Cardiac Care,"Get on board to learn how mobile health offers significant potential in providing effective, efficient and appropriately personalized cardiac care."
  October 2014 ,Skin Therapy Letter,Evidence for Dietary Influences on Atopic Dermatitis,This review examines the relationship of atopic dermatis and food allergies. Do elimination diets or dietary supplements offer clinical benefit?
  October 2014 ,BMC Pulmonary Medicine,Fluticasone Furoate for Asthma in Adults and Adolescents,"Inhaled corticosteroids are a mainstay of therapy for persistent asthma, but suboptimal adherence with twice-daily use is widespread."
  October 2014 ,Future Oncology,Translating Genetic Risk for Prostate Cancer to the Clinic,"With the introduction of genome-wide association studies, 78 susceptibility loci associated with prostate cancer risk have been identified. Which ones can be used clinically?"
  October 2014 ,American Heart Journal,Erythropoiesis-Stimulating Agents in STEMI,Do ESA's pull their weight in a post MI patient treatment regimen?
  October 2014 ,Clinical Endocrinology,Testosterone and Mortality,Can testosterone replacement slow disease progression and reduce risk of mortality in men?
  October 2014 ,Nephrology Dialysis Transplantation,Rare Renal Diseases: Improving the Quality of Evidence,"How do clinicians determine which renal diseases are rare, and how does that affect disease management?"
  October 2014 ,BMC Neurology,Mobilization After rtPA Within 24 Hrs of Acute Stroke,"AVERT, a large, ongoing international phase III trial, tests whether starting out of bed activity within 24 hours of stroke onset improves outcome. What factors might influence inclusion of patients?"
  October 2014 ,BMC Endocrine Disorders,Effect of Dietary Prebiotic Supplementation in Pre-diabetes,Can prebiotics decrease risk of type 2 diabetes?
  October 2014 ,Alimentary Pharmacology & Therapeutics,Cost-effectiveness Analysis of Sofosbuvir Treatment of HCV,Is the drug combination of sofosbuvir plus peginterferon/ribavirin considered to be more cost-effective than current treatment regimens for chronic hepatitis C genotype 1 infection?
  October 2014 ,Cardiovascular Ultrasound,Interobserver Reliability of Echocardiography in PE,This study found considerable differences in the interobserver reproducibility of echocardiographic findings in patients with pulmonary embolism. Which measurement was the least user dependant?
  October 2014 ,Newborn & Infant Nursing Reviews,Extrauterine Growth Restriction: Nutritional Practices in NICU,"Extrauterine growth restriction is a major clinical problem for prematurely born neonates, especially critically ill preterm neonates, and malnutrition in the neonatal intensive-care unit remains common."
  October 2014 ,Future Virology,Current Perspectives on HPV Vaccination,This article reviews the history and future of the HPV vaccine.
  September 2014 ,BMC Psychiatry,APOE Genetic Variants and Cognitive Function in Older Men,Might specific APOE polymorphisms confer a beneficial effect on cognition in elderly men?
  September 2014 ,Current Opinion in Pulmonary Medicine,Cytotoxic Agents in Sarcoidosis: Which One to Choose?,Therapeutic management of Sarcoidosis is challenging due to the variations in disease manifestation and clinical course.
  September 2014 ,Current Opinion in Neurology,Treatment of Advanced Parkinson's Disease,This review summarizes the currently available treatment strategies for addressing the complex symptoms of advanced Parkinson's disease.
  September 2014 ,American Journal of Cardiovascular Drugs,p38 MAP Kinase Inhibition in Cardiovascular Disease,Therapeutic inhibition of p38 MAPKs has been the focus of comprehensive research in the last 2 decades -- to attenuate inflammation. What's the upshot?
  September 2014 ,Cardiovascular Diabetology,DPP-4 Inhibitor and Alpha-GI: Endothelial Function Effects,Do DPP-4 inhibitors have protective effects on endothelial function?
  September 2014 ,Journal of the American Board of Family Medicine,Statin Assignment With 2013 Guideline vs 2001 Guideline,Does the new method match statin assignment to total plaque burden better than the older one?
  September 2014 ,BMC Anesthesiology,Anesthesia Machines and the Development of ARDS,Is the replacement of anesthesia machines associated with lower rates of acute respiratory distress syndrome?
  September 2014 ,Liver International,Fibrosis Staging by Elastometry and Blood Test in Chronic HCV,How effective is the combination of elastometry and a blood test at properly staging fibrosis in patients with chronic hepatitis C?
  October 2014 ,International Journal of Clinical Rheumatology,Aiming for Remission in Psoriatic Arthritis,How should remission be defined in psoriatic arthritis?
  October 2014 ,Current Opinion in Ophthalmology,The Cost of Genetic Testing for Ocular Disease: Who Pays?,Genetic testing for ocular diseases is beneficial but can be costly. Learn how to determine whether a patient's insurance will pay -- and what to do if they won't.
  October 2014 ,BMC Pulmonary Medicine,Safety and Efficacy of Proprietary Glycopyrronium MDI in COPD,Find out how proprietary glycopyrronium MDI stacks up to a placebo in patients with COPD.
  October 2014 ,Pharmacogenomics,"Genetic Polymorphisms, Methotrexate, and Outcome in RA",Might specific genetic variants serve as biomarkers to predict response and toxicity of methotrexate in treatment of rheumatoid arthritis?
  October 2014 ,European Heart Journal,Efficacy and Safety of Evolocumab in Hyperlipidaemic Patients,Will the large unmet need for well tolerated LDL-C reducing agents be addressed with this new targeted therapy?
  October 2014 ,Translational Lung Cancer Research,Is Surgery Still the Best Option for Early Stage NSCLC?,"With the increasing number of management options for early stage lung cancer, the role of surgery in this disease subset has been questioned."
  October 2014 ,Alimentary Pharmacology & Therapeutics,Predictors of Reflux Esophagitis Healing,"How can clinicians properly predict the outcome of reflux esophagitis, one manifestation of GERD, in patients after treatment with proton pump inhibitors?"
  October 2014 ,Current Opinion in Nephrology and Hypertension,Interventional Management in Hypertension,"What types of device-based interventions to lower drug-resistant hypertension have been developed over the last number of years, and how effective are they?"
  October 2014 ,U.S. Pharmacist,Screening and Treatment of Pediatric Dyslipidemias,When should lipid-lowering agents be initiated in pediatric patients with dyslipidemia?
  October 2014 ,Journal of the American Geriatrics Society,Cognitive Function in Older Adults With CKD,Studies have indicated that elderly adults with impaired kidney function have a greater risk of cognitive impairment. Could the protein cystatin C serve as a useful biomarker for cognitive decline?
  October 2014 ,Menopause,Recommendations for Clinical Care of Midlife Women,"As women enter midlife, what types of potential health problems could they face, and how should they best be cared for during this stage of life?"
  October 2014 ,BMC Family Practice,Perceived Quality of Life in COPD Patients,"COPD can have a strong impact on the physical, emotional, and mental well-being of patients. How do patients' perceptions of their disease impact their HRQoL?"
  October 2014 ,BMC Urology,Changing Paradigms in Management of mCRPC,Newly approved hormonal treatments and chemotherapeutic agents offer a new treatment paradigm for metastatic castration resistant prostate cancer.
  October 2014 ,BMC Psychiatry,Culturally Sensitive Psychosocial Interventions,Many groups with high mental distress face significant barriers in accessing mental health care. Can a culturally sensitive intervention be effective in reaching these under-served individuals?
  October 2014 ,Future Microbiology,New Perspectives in Management of P. aeruginosa Infections,"This review highlights recent investigational strategies for prevention and therapy of Pseudomonas aeruginosa infection, a nosocomial pathogen especially problematic in the immunocompromised."
  October 2014 ,International Journal of Clinical Practice,Comparing Regimens for Diabetic Peripheral Neuropathic Pain,This study evaluated 3 widely used treatment options for diabetic peripheral neuropathic pain. How do they compare in terms of safety and tolerability?
  October 2014 ,Interventional Cardiology,Cardiac MRI Catheterization: 10-Year Experience and Review,What don't you know about MRI-guided cardiac interventions?
  October 2014 ,Journal of the American College of Cardiology,Acute Kidney Injury After CABG Versus PCI,Is there a higher risk for AKI with multivessel CABG vs PCI -- as an initial revascularization strategy?
  October 2014 ,AIDS,Monotherapy for HIV Patients on Virological Suppression,Are HIV patients able to maintain virological suppression when treated with ATV/r monotherapy rather than triple therapy?
  October 2014 ,Liver International,Old and New Diagnostic Tools in the Management of Chronic HBV,"Clinicians have a wide array of tools to investigate, diagnose, and monitor hepatitis B. This new review describes some of the options."
  October 2014 ,American Heart Journal,Glucose Abnormalities in Patients With AMI,Learn why acute myocardial infarction may be a golden opportunity for glucose screening and early diabetes detection. . .
  October 2014 ,Journal of Pediatric Psychology,Psychological Therapies for Children With Chronic Pain,This systemic review examines the latest evidence for a variety of psychological interventions for treatment of chronic pain in children and adolescents. Do they provide long-term relief?
  October 2014 ,BMC Endocrine Disorders,Antihyperglycemics and Glycemic Control in Patients With T2D,Why are antidiabetic regimens changed in patients with type 2 diabetes?
  October 2014 ,HIV Medicine,Reasons for Choosing ATV/r  vs. EFV-Based First-Line Regimens,This study compares the reasons for choosing one first-line ART regimen over another.
  October 2014 ,Journal of Viral Hepatitis,Watchful Waiting in Chronic Hepatitis C,Patients with hepatitis C who have been advised to defer treatment in favor of watchful waiting often have high rates of depression. How can clinicians reassure them during this period?
  October 2014 ,Nutrition and Metabolism,Effect of Macrobiotic Ma-Pi 2 Diet on Type 2 Diabetes,Would your patients with type 2 diabetes benefit from this macrobiotic diet?
  October 2014 ,Rheumatology,Spondyloarthritis Unifying Concepts to Improved Treatment,This article reviews the pathophysiologic background and promising novel therapeutic options for spondyloarthritis.
  October 2014 ,Age and Ageing,Effects of Medications With Anti-Cholinergic Properties,"Drugs with anti-cholinergic properties are commonly prescribed in the elderly, but can have adverse effects. Do they contribute to delirium and cognitive impairment?"
  October 2014 ,Critical Care,Adverse Events of Ventilation in Adults With ARDS,Learn more about adverse events of high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome.
  October 2014 ,Journal of Cardiovascular Electrophysiology,Chronic Kidney Disease and ICD Related Complications,Find out more about the association between kidney function and the occurrence of ICD related complications.
  October 2014 ,Journal of the National Cancer Institute,"Discussions About Trials in Lung, Colorectal Cancer Patients",Gain a better understanding of how cancer patients learn about the possibility of participating in clinical trials.
  October 2014 ,American Journal of Clinical Dermatology,Biologic Therapy With Topical Treatment in Psoriasis,Does adjuvant topical therapy benefit patients undergoing biologic therapy for psoriasis?
  October 2014 ,Cardiovascular Diabetology,Metformin and Lower AF Risk Among Patients With T2DM,Can this antidiabetic agent decrease risk of atrial fibrillation?
  October 2014 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Tenofovir Alafenamide vs. Tenofovir Disoproxil Fumarate,How safe and effective is tenofovir alafenamide as part of a single-tablet regimen for the initial treatment of HIV?
  October 2014 ,BMC Anesthesiology,Glucose Prediction by Analysis of Exhaled Metabolites,Can patients in the ICU have their blood glucose levels accurately monitored by exhaled breath analysis?
  October 2014 ,European Heart Journal,Prasugrel Plus Bivalirudin vs Clopidogrel Plus Heparin STEMI,"Until now, whether prasugrel plus bivalirudin is a superior strategy to unfractionated heparin plus clopidogrel in patients with STEMI undergoing primary PCI has never been assessed in specifically designed randomized trials."
  October 2014 ,Journal of the American College of Cardiology,Impact of Renal Denervation on 24-Hour Ambulatory BP,Does renal denervation have a lasting impact on ambulatory blood pressure?
  October 2014 ,Diabetes Care,We Can Change the Natural History of Type 2 Diabetes,Should prediabetes and early diabetes be treated more aggressively? Is time being wasted?
  October 2014 ,Cancer Control: Journal of the Moffitt Cancer Center,Risks and Benefits of Phase 1 Clinical Trial Participation,"Phase 1 clinical trials represent an option for many cancer patients who progress through frontline therapy, but they are not without risk. Are these trials right for your patients?"
  October 2014 ,Pediatric Pharmacotherapy,Investigational Use of Meningococcal Serogroup B Vaccine,The investigational vaccine for N. meningitidis serogroup B has already shown significant advancement in reducing the impact of sepsis and meningitis worldwide.
  October 2014 ,Diabetes Care,Diabetic Foot Ulcers Without Clinical Signs of Infection,Should all diabetic foot ulcers be cultured and treated with antibiotics? Or just ones showing signs of infection?
  October 2014 ,Endocrine Practice,Insulin Degludec 200 U/mL vs 100 U/mL in Type 2 Diabetes,How do efficacy and hypoglycemia compare between insulin degludec 200 U/mL and 100 U/mL?
  October 2014 ,Pediatric Pharmacotherapy,New Agents and Assessment Tools for Treating ADHD,What new treatment options and assessment tools are available for the treatment of ADHD?
  October 2014 ,Modern Pathology,High EGFR Gene Copy Number in Triple-Negative Breast Cancer,Recent studies suggest that EGFR copy number may be useful for predicting outcomes in patients with triple-negative breast cancer and for selecting patients for anti-EGFR-targeted therapy.
  October 2014 ,American Heart Journal,Reasons for Warfarin Discontinuation in ORBIT-AF,Delve into the real reasons for stopping warfarin in patients with atrial fibrillation.
  October 2014 ,Annals of Oncology,ESO-ESMO Consensus Guidelines for Advanced Breast Cancer,This international consensus guideline offers updated recommendations for the management of advanced breast cancer.
  October 2014 ,Current Opinion in Allergy and Clinical Immunology,What's New in the Topical Treatment of Allergic Skin Diseases,Don't be rash; instead get the latest updates to make informed evidence-based decisions.
  October 2014 ,Spine,Thoracic Disc Disorders With Myelopathy,How do the surgical approaches for thoracic disc disorders with myelopathy differ -- and how has their use changed in the last decade?
  October 2014 ,Menopause,Genitourinary Syndrome of Menopause,"What does the term genitourinary syndrome of menopause encompass, and have clinicians come to an agreement on what it means?"
  October 2014 ,Current Opinion in Infectious Diseases,Respiratory Viruses and Their Impact in Healthcare,This article reviews the major impact that respiratory viruses have on healthcare.
  October 2014 ,British Journal of Cardiology,News From British Cardiovascular Society 2014 Conference,Hit the highlights from this year's British Cardiovascular Society 2014 Annual Conference.
  October 2014 ,International Journal of Clinical Practice,Aortic Valve Disease,"This educational review covers the pathophysiology, presentation and assessment of aortic stenosis and aortic regurgitation. What are the latest treatment options?"
  October 2014 ,Cardiovascular Diabetology,Calcium Intake and CVD Risks in Older Patients With T2DM,How does calcium affect CV risk in older patients? Should they take supplements?
  October 2014 ,Annals of Cardiothoracic Surgery,LVAD Cost for End-Stage HF Patients Ineligible for Transplant,"LVAD destination therapy improves survival and QoL, but does it offer a big enough bang for the buck?"
  October 2014 ,The British Journal of Dermatology,Biological Therapies for Psoriasis: Effects on Reproduction,Are biological therapies for psoriasis safe to use in the pregnant patient? What impact might they have on paternal fertility and mutagenicity?
  October 2014 ,Liver International,Second Wave Anti-HCV Protease Inhibitors,Are new second wave protease inhibitors a viable alternative to pegylated interferon and antivirals in the treatment of chronic hepatitis C?
  October 2014 ,BMC Pulmonary Medicine,Lung Transplantation in Idiopathic Pulmonary Fibrosis,Find out more about lung transplantation survival and wait-list survival among patients with idiopathic pulmonary fibrosis.
  October 2014 ,BMC Dermatology,Low Rate of Dermatology Outpatient Visits in Asian-Americans,Are there cultural or other factors that might account for the low rate of Asian-Americans seen by dermatologists?
  October 2014 ,BMC Public Health,HPV Catch-Up Vaccination of Young Women,HPV vaccine is generally recommended for younger girls--but how old is too old? Would a catch-up vaccination of older girls have beneficial effect?
  October 2014 ,Respiratory Research,Umeclidinium/Vilanterol and Umeclidinium in COPD,Are these agents safe and effective for long-term use in COPD?
  November 2014 ,Alimentary Pharmacology & Therapeutics,Patients With Chronic HCV Who Need Early Treatment,"Is there an efficient way to predict disease progression in patients with chronic hepatitis C, and how does this assist clinicians with determining which patients might need early treatment and close monitoring?"
  November 2014 ,Journal of the National Cancer Institute,The Colon Cancer Recurrence Score Predicts Recurrence Risk,How well does this 12-gene colon cancer assay predict the risk of recurrence in rectal cancer patients?
  November 2014 ,International Ophthalmology Clinics,Surgical Management of Pseudoexfoliation Glaucoma,Find out about the surgical strategies to achieve optimal outcomes and minimize the risk of complications in pseudoexfoliation glaucoma.
  November 2014 ,Pediatric Critical Care Medicine,Intensive Care Treatment of Uncontrolled Status Epilepticus in Children,Learn best evidence strategies for intensive care treatment of refractory status epilepticus in children.
  November 2014 ,Personalized Medicine,Personalizing Busulfan Therapy for Children Undergoing HSCT,Can genotyping individualize pediatric busulfan dosing and decrease potential for toxicity?
  October 2014 ,Cancer Control: Journal of the Moffitt Cancer Center,Participation of the Elderly Population in Clinical Trials,What barriers prohibit the elderly from greater participation in clinical trials and how can they be surmounted?
  October 2014 ,Respiratory Research,Acute Bronchodilator Responses in Moderate to Severe COPD,Do bronchodilators lose their punch over time -- in patients with moderate to severe COPD?
  October 2014 ,Nephrology Dialysis Transplantation,Is CKD-Mineral Bone Disorder Really a Syndrome?,"How do clinicians classify chronic kidney disease-mineral bone disorder, and how could the classification affect patient care?"
  October 2014 ,Alimentary Pharmacology & Therapeutics,Treatment of Fistulizing Perianal Crohn's Disease,Is combined surgical and medical treatment of fistulizing Crohn's disease better than either of those on their own?
  October 2014 ,Preventing Chronic Disease,Toward an Integrated Public Health Approach for Epilepsy,"People with epilepsy need better coordinated care, social support, improved treatments and greater social acceptance. How can we make epilepsy a public health priority?"
  October 2014 ,HIV Medicine,Etravirine in HIV-1-Infected Children and Adolescents,How safe and effective is etravirine in a treatment-experienced pediatric population?
  October 2014 ,Journal of Viral Hepatitis,Liver Transplant Recipients With Recurrent HCV Genotype 1,"Although the success of antiviral treatments remains limited in liver transplant recipients, how might clinicians best predict those who will respond?"
  October 2014 ,Journal of Clinical Rheumatology,Effect of Green Tea Extract on Uric Acid and Urate Clearance,Does green tea extract have hypouricemic effects in healthy individuals?
  October 2014 ,Kidney International,Prescriptions for Dietary Sodium in Patients With CKD,Is a low sodium diet recommended for all patients with CKD? What is the general consensus among clinicians?
  October 2014 ,Prostate Cancer and Prostatic Diseases,Updated Imaging Trends in Men Diagnosed With Prostate Cancer,The use of imaging tests in patients with prostate cancer is on an upward trend -- but is it overutilized?
  October 2014 ,Current Opinion in Pulmonary Medicine,The Impact of Sleep and Hypoxia on the Brain,Get in-the-know about obstructive sleep apnea-induced brain injury.
  October 2014 ,American Journal of Cardiovascular Drugs,Can a Pregnancy Hormone Save Lives in Acute Heart Failure?,Learn what pleiotropic effects are exerted through a complex and intricate signaling cascade involving the relaxin-family peptide receptor-1 and much more.
  October 2014 ,The American Journal of Gastroenterology,Optimizing Adequacy of Bowel Cleansing for Colonoscopy,What is the most effective way to properly cleanse the bowel in preparation for a colonoscopy?
  October 2014 ,Current Opinion in Psychiatry,Placebo Effects: The Contribution of Psychology,Research and theory on placebo effects has mainly focused on the neurobiological mechanisms. What insights does the psychological model add?
  October 2014 ,Cardiovascular Diabetology,A Score to Quantify Coronary Plaque Vulnerability in T2DM,Can this score predict whether a coronary lesion may be cause for an ACS?
  November 2014 ,Exercise and Sport Sciences Reviews,Cardiopulmonary Exercise Testing Applications in HF,The authors present evidence for a new cardiopulmonary exercise testing paradigm in patients with heart failure.
  November 2014 ,Malaria Journal,Progress in the Development of Anti-malarial Quinolones,"With resistance to the first-line anti-malarial drugs emerging, the development of anti-malarial quinolones may be our next useful tool."
  November 2014 ,Current Opinion in Ophthalmology,Diabetic Macular Edema: Changing Treatment Paradigms,Find out how paradigms for treating diabetic macular edema are evolving.
  November 2014 ,Journal of the American College of Cardiology,"Amiodarone, Anticoagulation, and Clinical Events in AF",What's the connection between the use of amiodarone and adverse events -- in patients with atrial fibrillation?
  November 2014 ,Pediatric Pharmacotherapy,Cefdinir Use in Children,"Cefdinir is a very effective drug for use in pediatrics. Its broad spectrum of activity, however, poses the risk for bacterial resistance."
  November 2014 ,Personalized Medicine,Legal Aspects of Biobanking for Personalized Medicine,Learn how a more transparent framework and flexible regulations could create an optimal environment for biobanking.
  November 2014 ,Pharmacogenomics,Targeting Pathways Downstream of KRAS in Lung Adenocarcinoma,This article details the specific signaling pathways downstream of KRAS that are critical for tumorigenesis in lung adenocarcinomas. How might they be leveraged for therapeutic targeting?
  November 2014 ,Clinical Endocrinology,Managing an Adolescent Girl Presenting With Features of PCOS,Learning about a PCOS diagnosis can be worrisome to adolescent girls. What management strategies are effective?
  November 2014 ,Breast Cancer Research,Feasibility of Personalized Peptide Vaccination for mrTNBC,"Personalized peptide vaccination may be a novel treatment modality for metastatic recurrent breast cancer patients, a feasibility study shows."
  November 2014 ,AIDS,Opportunistic Infections and AIDS Malignancies After ART,How common are opportunistic infections and malignancies in HIV patients starting cART?
  November 2014 ,Liver International,Coffee Consumption in NAFLD Patients,"Could coffee consumption help to lower the risk of severe fibrosis in NAFLD patients with lower insulin resistance and, if so, why?"
  November 2014 ,Annals of Oncology,PD-L1 Overexpression With Activating EGFR Mutations in NSCLC,"In this study, the authors explore the prognostic relevance of PD-L1 expression in patients with surgically resected NSCLC."
  November 2014 ,Endocrine Practice,Decreased Mortality With Glycemic Control in Critically Ill,What are risks and benefits of tight glycemic control in ICU patients?
  November 2014 ,Alimentary Pharmacology & Therapeutics,Certolizumab Pegol in the Treatment of Crohn's Disease,"What does this new study tell us about the safety, efficacy, and tolerability of the anti-TNF agent, certolizumab pegol, in the treatment of Crohn's disease?"
  November 2014 ,Annals of Surgery,Long-term Outcomes After Total Pancreatectomy,Does total pancreatectomy with islet cell autotransplantation show long-term benefits?
  November 2014 ,BMC Endocrine Disorders,Vitamin D & Bone Health in Adults With Diabetic Nephropathy,Do patients with diabetes and kidney disease need higher vitamin D doses?
  November 2014 ,BMC Anesthesiology,Ropivacaine to Treat Acute Lung Injury,Could ropivacaine be a promising therapeutic agent for treating acute lung injury and acute respiratory distress syndrome?
  November 2014 ,Spine,Cost-Effectiveness of Minimal Access vs Open Spine Surgery,How do these two approaches compare in terms of cost-effectiveness? A new review examines the evidence.
  November 2014 ,American Journal of Clinical Pathology,Clinical Laboratory Immunology: An Indispensable Player,Learn about training programs and career tracks for clinical laboratory immunologists--key contributors to the diagnosis and management of patients with immune-mediated conditions.
  November 2014 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Violence Risk Screening Identifies Return ED Injury Visits,Can certain factors predict the likelihood of repeat ED visits due to recurrent violent injury? A new study provides some insight.
  November 2014 ,Journal of the National Cancer Institute,Effect of Bisphosphonates on Metastases in Breast Cancer,How does bisphosphonate use impact the risk of bone metastasis in women with breast cancer? A new study investigates.
  November 2014 ,Current Opinion in Gastroenterology,Gastrointestinal Bleeding in Cardiac Patients,"As more older patients seek treatment for cardiovascular disease, how likely are they to develop gastrointestinal bleeding, and how can they be most effectively managed?"
  November 2014 ,The Hospitalist,Hospitalists Take Charge of Antibiotic Resistance,Hospitalists are key figures in promoting antimicrobial stewardship. What steps can you take to ensure proper antibiotic use in your hospital?
  November 2014 ,The British Journal of Dermatology,Guidelines for the Management of Cutaneous Warts,"This guideline provides up-to-date, evidence-based recommendations for the management of infectious cutaneous warts caused by HPV infection."
  November 2014 ,Personalized Medicine,Attitudes Toward Genetic Testing and Its Role in Healthcare,Do patients change health risk behaviors after receiving their genetic risk disease estimates?
  November 2014 ,Clinical Endocrinology,Effects of Up to 15 Years of rhGH Replacement on Bone in GHD,Does sustained growth hormone replacement decrease fracture risk?
  November 2014 ,HIV Medicine,Increased Risk of CVD With Age in HIV-Positive Men,How does HIV infection and age affect risk for cardiovascular disease?
  November 2014 ,Clinical Lipidology,Diet and Lifestyle Interventions on Lipids,How will personalized medicine add to non-pharmacologic prevention measures aimed at improving lipid levels?
  November 2014 ,BMC Public Health,The Relationship Between Sugar Intake and Dental Caries,"While the relation between dietary sugars and dental caries is undisputed, there is little evidence for 'how much is too much.' What should the goal be?"
  November 2014 ,Journal of Viral Hepatitis,Sofosbuvir Plus Ribavirin in Patients With Genotype 2 HCV,"How effective is sofosbuvir in combination with ribavirin in treatment-naive and previously treated patients with chronic genotype 2 HCV infection, including the elderly and those with cirrhosis?"
  November 2014 ,Journal of Glaucoma,Ocular Decompression Lowers IOP After Intravitreal Injection,A new study examines the effect of preinjection eye decompression with cotton swabs on IOP following intravitreal injections.
  November 2014 ,BMC Anesthesiology,Preconditioning of Lower Limb Muscle Tissue Oxygenation,Does ischemic preconditioning have effects on muscle tissue oxygen saturation in patients undergoing surgical revascularization of the lower limb?
  November 2014 ,Women's Health,GnRH Agonist Triggers and Their Use in ART,What does this latest study tell us about the effectiveness of GnRH agonist triggers in the realm of assisted reproductive technology?
  November 2014 ,European Heart Journal,Prospective Validation of Bleeding Classification in Prodigy,Feel the bite of BARC's impact on interventional cardiology research and more. . .
  November 2014 ,Chinese Clinical Oncology,Algorithm for Management of Metastatic Cutaneous Melanoma,Find out how best to integrate the currently available treatment options for cutaneous melanoma in various clinical scenarios.
  November 2014 ,American Journal of Transplantation,HCV Infection and Kidney Transplantation in 2014,"Get current on management strategies for HCV infection in kidney transplantation, learning more about recent advances in interferon-free treatment regimens."
  November 2014 ,Cardiovascular Diabetology,Biomarkers After Bariatric Surgery and Risk of CVD,Should this biomarker be measured after bariatric surgery to assess cardiovascular risk?
  November 2014 ,Current Opinion in Nephrology and Hypertension,Complete Inhibition of the Renin-angiotensin-aldosterone System,Are there adverse events associated with renin-angiotensin-aldosterone system blockade in combination with monotherapy in individuals with chronic kidney disease?
  November 2014 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,End-Stage Kidney Disease and Transplantation in HIV Patients,Is kidney transplantation a good option for management of end-stage kidney disease in HIV-positive patients?
  November 2014 ,Translational Lung Cancer Research,Preoperative Mediastinal Lymph Node Staging for NSCLC,Get up to date with the latest guidelines for preoperative lymph node staging for non-small cell lung cancer.
  November 2014 ,Alimentary Pharmacology & Therapeutics,The Management of Pediatric Nonalcoholic Fatty Liver Disease,How should clinicians approach the management of their young patients with this disease?
  November 2014 ,Personalized Medicine,Targeted Next-Generation Sequencing for Genetic Disorders,Will next-generation sequencing change the landscape of diagnostic testing for inherited disorders?
  November 2014 ,Future Oncology,Sorafenib as First- or Second-line Therapy in Metastatic RCC,Is sorafenib a safe and effective therapeutic option in metastatic RCC?
  November 2014 ,AIDS,Use of Statins and Malignancies Among HIV Patients on ART,Is statin use among HIV positive patients associated with a lower risk of cancer?
  November 2014 ,Cardiovascular Diabetology,B12 Deficiency Is Associated With Adverse Lipids in T2D,Should patients with type 2 diabetes be screened regularly for vitamin B12 deficiency?
  November 2014 ,The Journal of Emergency Medicine,An ED Sign-Out Checklist Improves Transfer at Shift Change,"The use of a novel, electronic sign-out checklist may provide more accurate and efficient handoffs at shift change, a new study reports."
  November 2014 ,Cancer Control: Journal of the Moffitt Cancer Center,Studying Cancer Treatment in the Elderly Patient Population,"Which factors hinder elderly patients from participation in phase 1, phase 2, and phase 3 trials? This review provides strategies for overcoming these hindrances."
  November 2014 ,Nanomedicine,Drug Delivery: Lessons to Be Learnt From Leishmania Studies,"Recent studies on treatment for leishmaniasis can serve as models for increasing our understanding of drug delivery systems, as well as facilitating novel ways of improving drug efficacy and delivery."
  November 2014 ,Annals of Oncology,Impact of HPV on Treatment for Head and Neck Cancer,"Find out why HPV-associated oropharyngeal carcinoma appears to be a distinct entity with different epidemiology, biology, and clinical outcomes."
  November 2014 ,Journal of the American Board of Family Medicine,Advances in Diagnosis and Treatment of Latent TB Infection,"While mortality from tuberculosis is declining, it remains a major public health concern. What's the latest on diagnosis and treatment?"
  November 2014 ,Current Opinion in Rheumatology,Therapy of Myositis: Biological and Physical,What therapies are available for the treatment of myositis?
  November 2014 ,BMC Anesthesiology,Electrical Impedance Tomography During Abdominal Surgery,Is electrical impedance tomography of the lungs feasible and useful in patients undergoing major open upper abdominal surgery?
  November 2014 ,Brain,Large-Scale Brain Networks in Generalized Epilepsy,Have cutting-edge MRI techniques furthered our understanding of the underlying mechanisms of juvenile myoclonic epilepsy to the point where the term 'idiopathic' no longer applies?
  November 2014 ,Human Reproduction,Effect of Anesthesia on Pain Associated With IUD Insertion,Could anesthesia help to reduce the pain associated with IUD insertion in women without a previous vaginal delivery?
  November 2014 ,Nutrition and Metabolism,Muscle p70S6K Phosphorylation From Soy and Dairy Rich Meals,How does metabolic syndrome affect the mTOR (primary regulator of muscle protein synthesis) pathway to feeding?
  November 2014 ,Medicine and Science in Sports and Exercise,L-Citrulline Improves Splanchnic Perfusion During Exercise,A new study assesses the effects of L-citrulline supplementation and the role it plays in reducing intestinal injury during strenuous exercise.
  November 2014 ,Diabetes Care,Spinal Cord Stimulation in Diabetic Peripheral Neuropathy,Does spinal cord stimulation result in considerable relief for patients with diabetic peripheral neuropathy?
  November 2014 ,Menopause,Hypercalciuria and Hypercalcemia in Older Women,Are women taking vitamin D and calcium supplements at an increased risk for developing hypercalciuria and hypercalcemia?
  November 2014 ,The American Journal of Gastroenterology,Pregnancy Complications Among Women With Celiac Disease,"Does research suggest that women with celiac disease are more likely to experience pregnancy complications and adverse birth outcomes and, if so, why?"
  November 2014 ,BMC Anesthesiology,Rocuronium Blockade Reversal With Sugammadex vs. Neostigmine,Which relaxant-binding agent should be used for the reversal of moderate rocuronium-induced neuromuscular blockade?
  November 2014 ,Current Opinion in Pulmonary Medicine,Dry Powder Inhalers in Cystic Fibrosis,"Dry powder inhalers may improve patient adherence, but are they as clinically effective, safe and cost-effective as nebulized antibiotics?"
  November 2014 ,Critical Care,Early Sedation and Outcomes of Mechanically Ventilated Patients,What's wrong with early deep sedation in mechanically ventilated patients?
  November 2014 ,Schizophrenia Bulletin,"Delusions, Anger, and Serious Violence",The findings of this study have important implications for identification of psychotic patients at risk for violent behavior and management of their risk.
  November 2014 ,Kidney International,Incidence of Fracture in Chronic Kidney Disease,"How common are falls and fractures in adults with chronic kidney disease, and how does this risk help clinicians with patient management and decision making?"
  November 2014 ,Journal of Clinical Rheumatology,Older Age at Rheumatoid Arthritis Onset and Comorbidities,Do age at onset and comorbidities predict rheumatoid arthritis response to biologic therapy?
  November 2014 ,Future Microbiology,M. tuberculosis Evolutionary Pathogenesis & Drug Development,"What have we learned from recent studies on the evolution of M. tuberculosis, and how might this help foster novel therapeutic approaches to TB?"
  November 2014 ,BMC Ophthalmology,IOP Rise Predicts Vision Improvement After IVTA for DME,Is there a link between IOP rise and visual acuity improvement after treatment with intravitreal triamcinolone acetonide for diabetic macular edema? This study investigates the possible connection.
  November 2014 ,Gastroenterology,ABT-450/r/Ombitasvir and Dasabuvir for HCV ,Can this interferon-free regimen bring about a complete virologic response in patients with HCV genotype 1b infection?
  November 2014 ,Current Opinion in Allergy and Clinical Immunology,Trends in Prevalence and Treatment of Ocular Allergy,Learn more about the latest strategies for managing seasonal and perennial allergic conjunctivitis and related disorders.
  November 2014 ,Journal of Viral Hepatitis,Treatment Options Beyond IFN-alpha and NUCs for Chronic HBV,What types of drug therapies are on the horizon for the future treatment of chronic hepatitis B?
  November 2014 ,BMC Urology,Dutasteride Plus Tamsulosin vs Tamsulosin Alone for BPH,This study assesses the economic value of tamsulosin alone or combined with dutasteride for the treatment of BPH. Which is more cost-effective?
  November 2014 ,Neurosurgical Focus,Endoscopic Endonasal Transsphenoidal Surgery,The authors present a 3-part checklist with the aim of reducing surgical errors when performing endoscopic transsphenoidal or anterior skull base surgery.
  November 2014 ,Nutrition and Metabolism,Effects of Dietary Components on HDL Measures,Learn how dietary folate affects HDL subfractions and apolipoprotein levels.
  November 2014 ,Headache,Meditation for Migraines: A Pilot RCT,Can a mindfulness-based stress reduction course based on meditation and yoga be a beneficial intervention for patients with migraine?
  November 2014 ,Medicine and Science in Sports and Exercise,Exercise Offsets the Effects of a High-Fructose Diet,High fructose consumption can lead to adverse health effects -- but regular exercise may offer some protection.
  November 2014 ,BMC Oral Health,Effect of Lactobacillus salivarius on Caries Risk,Could administration of the probiotic lactic acid bacteria L. salivarius help prevent dental caries?
  November 2014 ,Alimentary Pharmacology & Therapeutics,The Management of Cirrhosis in Women,What are the special concerns that women and their clinicians have to pay attention to when treating and managing cirrhosis?
  November 2014 ,Future Virology,RSV Implications for Subunit Vaccine Development,"After more than 50 years of research, there is renewed interest in developing an RSV vaccine, with many vaccines in development."
  November 2014 ,Rheumatology,Infliximab Regimens in Patients With Psoriatic Arthritis,This study examines infliximab dose regimens and outcomes in patients with psoriatic arthritis.
  November 2014 ,Women's Health,Update on Prognostic Markers for Endometrial Cancer,How could a better understanding of novel mutations and molecular profiles improve clinicians' ability to personalize treatment for women with endometrial cancer?
  December 2014 ,BMC Anesthesiology,Sugammadex for Reversing Rocuronium With Antibiotics Present,Does antibiotic use impact the recovery time from rocuronium-induced neuromuscular blockade with sugammadex reversal?
  December 2014 ,Annals of Oncology,PD-L1 Expression in Nonclear-Cell Renal Cell Carcinoma,Do patients with non-clear cell renal cell carcinoma have worse clinical outcomes when the tumors are PD-L1 positive?
  December 2014 ,Annals of Clinical Microbiology and Antimicrobials,Linezolid Susceptibility Results: A Surrogate for Tedizolid?,"Tedizolid is an oxazolidinon antibacterial approved for some Gram-positive infections, but commercial susceptibility testing products are not yet available. Could linezolid be used as a surrogate?"
  December 2014 ,BMC Infectious Diseases,Experience With the HCV Triple Therapy,What support is needed for patients undergoing the burdensome HCV triple therapy?
  December 2014 ,American Journal of Epidemiology,Paleolithic and Mediterranean Diet and Colorectal Adenomas,Could greater adherence to the Paleolithic or Mediterranean diets lower risk of incident colorectal adenomas?
  December 2014 ,European Heart Journal,Endothelial Microparticles and Cardiometabolic Risk,Are endothelial microparticles like bread crumbs toward cardiometabolic risk?
  December 2014 ,Neurosurgical Focus,An Approach for Skull Base and Nasopharyngeal Pathology,This case series highlights advantages and limitations of a combined endonasal and transoral approach for surgical management of the middle and posterior skull base and nasopharynx.
  December 2014 ,BMC Endocrine Disorders,Factors Associated With Midnight Salivary Cortisol in T1D,Is a disturbed circadian rhythm associated with depression in patients with type 1 diabetes?
  December 2014 ,Menopause,Vitamin D Levels and Menopause-related Symptoms,What does the latest research tell us about the connection between vitamin D levels and menopausal symptoms?
  December 2014 ,Alimentary Pharmacology & Therapeutics,"The Perceptions, Diagnosis, and Management of IBS",How do primary care clinicians handle both the diagnosis and management of IBS? This new study takes an in-depth look at their methods of managing the disease in patients.
  December 2014 ,Morbidity & Mortality Weekly Report,Pneumonia Hospitalizations in PCV Vaccinated Children,The data reported in this survey attests to the powerful impact of the pneumococcal conjugate vaccine program on pneumonia in young children.
  December 2014 ,International Journal of Clinical Practice,Adjunctive Aripiprazole in Patients With Major Depression,Can adjunctive aripiprazole provide significant benefits in patients with major depressive disorder who showed little improvement with antidepressants?
  December 2014 ,BMC Musculoskeletal Disorders,Visually Assessed Severity of Lumbar Spinal Canal Stenosis,"Using MRI findings, the authors investigate whether the degree of lumbar spinal canal stenosis is associated with leg pain and function."
  December 2014 ,Southern Medical Journal,"Fixed Drug Eruptions: Diagnosis, and Management",As many as 2-3% of patients taking medications will develop a cutaneous drug reaction. What drugs are the most frequent offenders?
  December 2014 ,Personalized Medicine,Overcoming Immune System Evasion: Personalized Immunotherapy,Will early detection of molecular and genetic characterizations improve personalized treatment of cancer?
  December 2014 ,BMC Anesthesiology,Intubation With a Left-Sided Double-Lumen Endobronchial Tube,This study investigates which direction of angulation is best to facilitate correct positioning of a double-lumen endobronchial tube.
  December 2014 ,Journal of the American College of Cardiology,Intestinal Trimethylamine-N-Oxide in Heart Failure,"Links between gut microbiota metabolism, TMAO formation, and cardiorenal pathophysiology are explored."
  December 2014 ,American Heart Journal,Death During Long-term Follow-Up After TAVR,Find out more about causes of death after transcatheter aortic valve replacement.
  December 2014 ,Diabetes,Trends in Incidence of T1D Among Non-Hispanic White Youth,Is the incidence of type 1 diabetes increasing in the very young?
  December 2014 ,The Journal of Invasive Cardiology,Loss of Patency and Femoral Stent Implantation,Primary patency is defined as a combination of vessel patency assessed by duplex ultrasound at the 12-month follow-up exam.
  December 2014 ,Future Microbiology,Bacterial Glycosidases in Pathogenesis and Glycoengineering,"This article highlights the role of bacterial glycosidases during infections, introducing their use as glycoengineering tools. What potential does this emerging field hold for biotherapeutics?"
  December 2014 ,BMC Infectious Diseases,"Social, Economic, and Health Impact of RSV","What can be done to reduce the social, health and economic impact of RSV?"
  December 2014 ,European Heart Journal,Statin Therapy and Adverse Limb Outcomes in PAD,Will more statin use in patients with PAD create fewer amputees?
  December 2014 ,BMC Urology,Renal Cell Carcinoma With Intramyocardial Metastases,"In this rare case, a patient presents with intramyocardial metastases from renal cell carcinoma. How was it diagnosed and treated?"
  December 2014 ,Journal of Hospice and Palliative Nursing,The Death Rattle Dilemma,What are we accomplishing when we treat death rattle?
  December 2014 ,Medicine and Science in Sports and Exercise,Exercise Prescription or Proscription in Colorectal Cancer,Can survivors of colorectal cancer safely meet the current recommended guidelines for exercise prescription?
  December 2014 ,Current Opinion in Ophthalmology,Presumed Ocular Histoplasmosis,This review provides new insights into the pathophysiology of presumed ocular histoplasmosis and the best approaches to managing this condition.
  December 2014 ,Breast Cancer Research,Modeling Luminal Breast Cancer Heterogeneity,Gain a better understanding of the heterogeneity in luminal breast cancers and the role combined targeting can play.
  December 2014 ,BMC Anesthesiology,Nasal O2 in Patients With Hypoxic Respiratory Failure,Is nasal high-flow oxygen therapy adequate when compared to conventional oxygen therapy in patients with hypoxic respiratory failure?
  December 2014 ,Future Virology,Dolutegravir: A New Option for HIV Treatment,"The new drug, dolutegravir may play an important role in the future treatment of HIV infection."
  December 2014 ,Translational Lung Cancer Research,ALK and Crizotinib: After the Honeymoon...What Else?,Find out about the promising therapeutic strategies to overcome crizotinib resistance in ALK-rearranged non-small cell lung cancer.
  December 2014 ,Nursing Economics,Bullying in the Nursing Workplace,"Although bullying can occur among co-workers, the most common form of bullying involves the abuse of power by superiors against subordinates."
  December 2014 ,Spine,Lumbar Disc Nomenclature: Version 2.0,The authors provide an updated nomenclature pertaining to lumbar disc pathology.
  December 2014 ,Personalized Medicine,Benefits and Burdens of Newborn Screening,Will technological advances in genome sequencing increase parental confusion about newborn screenings?
  December 2014 ,AIDS,ART for Prevention of Mother-to-Child Transmission,ART is recommended to HIV+ women for prevention of perinatal transmission of HIV. Are these women at risk of resistance after stopping the ART regimen?
  December 2014 ,Future Oncology,Prostate Changes Related to Therapy,"As new compounds are developed for prostate cancer treatment, it is important to document their effects on benign and neoplastic prostate tissue."
  December 2014 ,Malaria Journal,Stable Malaria Incidence Despite Control Strategies in Mali,"Despite the scaling up of malaria prevention and treatment in Mali, malaria incidence is not declining."
  December 2014 ,Journal of the American College of Cardiology,Second-Generation DES Implantation and 6- vs 12-Mo DAPT,What's the optimal duration of DAPT following 2nd-generation DES implantation?
  December 2014 ,Alcohol and Alcoholism,Drug-Dependent Patients Attending AA: How Do They Do?,Should young adults whose primary substance is not alcohol be referred to Alcoholics Anonymous when Narcotics Anonymous is unavailable?
  December 2014 ,Nanomedicine,Magnetic Nanoparticle-Mediated Hyperthermia,Recent clinical trials have suggested that magnetic nanoparticle-mediated hyperthermia may add a promising and novel approach to antitumor therapy. How does it work?
  December 2014 ,Headache,Economic Impact of Botox in Patients With Chronic Migraine,Does treatment of refractory chronic migraine with onabotulinumtoxinA reduce health care utilization and costs over time?
  December 2014 ,Menopause,Custom-compounded Bioidentical Hormone Therapy,Is there sufficient scientific safety and efficacy data to recommend the use of bioidentical hormones?
  December 2014 ,Current Opinion in Gastroenterology,Management of Gastric Cancer,What is the most effective treatment strategy for gastric cancer in the locally advanced setting? This new study explores surgical and drug therapy options.
  December 2014 ,BMC Anesthesiology,Liberal or Restricted Fluid Administration,How much intraoperative fluid should be given to a patient?
  December 2014 ,Diabetes Care,The SEARCH for Diabetes in Youth Study,How prevalent is diabetes in youth? What are risk factors for complications? Lean about key findings of a cohort study here.
  December 2014 ,BMC Musculoskeletal Disorders,Ankle-Foot Orthoses in Children With Cerebral Palsy,A new study analyzes the use of ankle-foot orthoses and treatment outcomes in children with cerebral palsy.
  December 2014 ,Southern Medical Journal,Menopausal HT in Postmenopausal Women: Risks and Benefits,Should menopausal hormone therapy be used as CVD prophylaxis? This review focuses on the complicated--and controversial--role that menopausal HT plays in cardiovascular protection.
  December 2014 ,Wounds,Surface Acoustic Wave Patch for Ischemic Feet,A new wave of ultrasound therapy gives another option for healing foot ulcers . . .
  December 2014 ,Emerging Infectious Diseases,Biomarker Correlates of Survival in Children With Ebola,Children infected with Ebola virus may benefit from different treatment than their adult counterparts.
  December 2014 ,U.S. Pharmacist,New Drug Review 2014,"Learn about new drug products now available for diabetes, COPD, depression, HCV, and athlete's foot."
  December 2014 ,BMC Anesthesiology,Effects of Ramosetron on Postoperative Nausea and Vomiting,This study compares ramosetron with ondansetron for the prevention of nausea and vomiting after a craniotomy.
  December 2014 ,BMC Psychiatry,Treatment Resistant Schizophrenia: A Survey of RCTs,"Nearly one third of schizophrenia patients don't respond to standard treatment protocols. What other interventions are available, and do they have quality evidence to support them?"
  December 2014 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Infrequent HIV Testing and Late Diagnosis Among Black MSM,Sexually active black men who have sex with men are not being tested for HIV according to the CDC guidelines.
  December 2014 ,Diabetes,"Insulin Regulates Brain Function, but How Does It Get There?",Learn why insulin is an important CNS regulatory peptide. Can it influence development of Alzheimer disease?
  December 2014 ,Annals of Cardiothoracic Surgery,Cost-Utility of LVAD for End-Stage Heart Failure,Find out more about the economics of end-stage heart failure management with LVADs.
  December 2014 ,Journal of Viral Hepatitis,Serum Markers for Fibrosis Staging in Chronic HBV and HCV,Do serum markers accurately predict the upper and lower end of liver fibrosis stage in patients with either hepatitis B or hepatitis C?
  December 2014 ,Critical Care,Procalcitonin for Reduction of Antibiotic Use in Asthma,Can serum procalcitonin levels be used to effectively and safely reduce antibiotic exposure in patients admitted for acute exacerbation of asthma?
  December 2014 ,BMC Anesthesiology,Potential Challenges of Veno-venous ECMO,Recognizing the benefits and effects of ECMO will help in the development of standardized ECMO clinical practices.
  December 2014 ,BMC Neurology,Moving Beyond Anti-Amyloid Therapy for Alzheimer's Disease,Recent Phase 3 trials of antibodies targeted at amyloid-beta removal in Alzheimer's disease patients have proved disappointing. Should this approach be abandoned?
  December 2014 ,Journal of Medical Case Reports,Lenalidomide in Refractory Diffuse Large B-Cell Lymphoma,Prognosis is poor for patients with multiply relapsed or refractory diffuse large B-cell lymphoma. Might the immunomodulator lenalidomide be effective in these patients?
  December 2014 ,BMC Dermatology,Innate Lymphoid Cells and the Skin,"Learn about the innate lymphoid cell family, their function in the skin, and their role in inflammatory skin diseases in this overview."
  December 2014 ,Future Virology,Targeting Toll-like Receptors for Antiviral Therapy,Toll-like receptors are promising targets for new therapies to treat viral infections or to improve vaccine efficacy.
  December 2014 ,Women's Health,Reducing Stroke in Women With Risk Factor Management,"Do women have a higher prevalence of stroke, mortality, and disability than men and, if so, how can both preventive strategies and treatment options be tailored to best suit them?"
  December 2014 ,Breast Cancer Research,Outsmarting Cancer: Biomarkers and Drug Response,Find out how combining biochemical profiles with genomic information helps predict drug response with greater accuracy.
  December 2014 ,BMC Urology,Ultra-Early vs Early Salvage ADT for Biochemical Recurrence,Find out how the timing of salvage ADT administration can impact the risk of biochemical recurrence in post-prostatectomy patients.
  December 2014 ,Social Cognitive and Affective Neuroscience,MDMA Enhances Emotional Empathy and Prosocial Behavior,"MDMA, commonly known as 'ecstasy', releases serotonin and norepinephrine. What effect does it have on different aspects of empathy and social behavior?"
  December 2014 ,American Journal of Kidney Diseases,GFR Decline as an End Point for Clinical Trials in CKD,Do GFR-based end points have strong enough relationships with important outcomes of CKD to be used in clinical trials?
  December 2014 ,Infection Control and Hospital Epidemiology,Epidemiology of MRSA Pneumonia in Community Hospitals,"Despite the decreasing incidence of invasive MRSA infections nationwide, the incidence of MRSA pneumonia in hospitals is rising."
  December 2014 ,Journal of Perinatology : Official Journal of the California Perinatal Association,Hepatitis B and C in Pregnancy,This article reviews the current recommendations for the management of hepatitis B or hepatitis C in pregnancy.
  December 2014 ,Journal of the National Cancer Institute,Effects of Soy on Gene Expression in Breast Cancer,Find out how soy may affect the expression of genes associated with breast cancer.
  December 2014 ,Journal of the American College of Cardiology,Epinephrine in Cardiac Arrest and Patients Outcomes,An old standby is evaluated for longer-term outcomes. Is it time to give epi the boot?
  December 2014 ,U.S. Pharmacist,Review of Selected NMEs 2014,"Read about new drug products for CTEPH, CLL, factor XIII-A deficiency, and Peyronie disease."
  December 2014 ,BMC Psychiatry,Cognitive Behavioral Group Therapy for Depression,Cognitive behavior therapy has been shown to be an effective treatment for depression. But is group CBT as effective as individualized therapy in a routine care setting?
  December 2014 ,Personalized Medicine,Personalized Medicine in Oncology: Ethical Implications,How can resource allocation remain fair with personalized treatment of cancer?
  December 2014 ,Journal of Viral Hepatitis,Predictors of the Stage of Liver Fibrosis in Chronic HBV,How can clinicians most accurately predict the state of liver fibrosis in their patients with chronic hepatitis B?
  December 2014 ,The British Journal of Dermatology,Guidelines for the Management of Onychomycosis 2014,"The guidelines presented in this article provide up-to-date, evidence-based recommendations for the diagnosis and management of fungal disease of the nails."
  December 2014 ,Future Neurology,Nonamyloid PET Biomarkers and Alzheimer's Disease,"Learn how PET biomarkers for neurodegeneration, neuroinflammation, and neurotransmission may improve Alzheimer's disease management."
  December 2014 ,Endocrine Practice,Review of Oral Cholecystographic Agents for Hyperthyroidism,Learn about efficacy of oral cholecystographic agents for thyrotoxicosis.
  December 2014 ,European Heart Journal,CABG vs PCI in Patients With 3-Vessel Disease,Learn more about long-term results from randomized trials of CABG vs PCI using drug-eluting stents.
  December 2014 ,Annals of Surgery,Roux-en-Y Gastric Bypass Vs. Adjustable Gastric Banding,Is gastric bypass or gastric banding more beneficial for obese patients with fatty liver disease?
  December 2014 ,BMC Endocrine Disorders,Quality of Life After Carpal Tunnel Release in Diabetes,Do patients with and without diabetes have improved quality of life years after carpal tunnel release?
  December 2014 ,Cardiovascular Diabetology,Influence of Insulin & Glargine on Circulating EPCs in T2DM,Does insulin therapy protect against diabetic microvascular disease by increasing endothelial progenitor cells?
  December 2014 ,BMC Musculoskeletal Disorders,Ultrasound and Paraffin Therapy for Carpal Tunnel Syndrome,This study examines the use of a wrist orthosis combined with therapeutic ultrasound or paraffin bath therapy for carpal tunnel syndrome. Did either method prove more effective?
  December 2014 ,American Journal of Clinical Pathology,Epstein-Barr Virus-Positive Pleural Effusion,"Many cases of pleural effusion remain unexplained, but an association with Epstein-Barr virus is sometimes found. What are the clinical and cytomorphologic features of EBV-associated PEs?"
  December 2014 ,American Journal of Epidemiology,Carbon Monoxide and Risk of Hospitalization Due to COPD,"Many studies have linked air pollution to increased rates of COPD exacerbations, but surprisingly, ambient carbon monoxide may actually have a beneficial effect."
  December 2014 ,BMC Oral Health,Association Between Psoriasis and Periodontitis,"Psoriasis and periodontitis are both chronic, inflammatory conditions. Is there a link between the two?"
  December 2014 ,Personalized Medicine,Personalized Medicine for Chronic Disease: COPD as Example,Does the technology exist to personalize medicine for chronic diseases like COPD?
  December 2014 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Perception of HIV Risk and Adherence to FEM-PrEP,Does perceived HIV risk influence patients' decisions to adhere to pre-exposure prophylaxis?
  December 2014 ,BMC Gastroenterology,Efficacy of Transoral Fundoplication to Treat Chronic GERD,Could transoral fundoplication improve clinical outcomes in patients who don't respond well to high-dose proton-pump inhibitors?
  December 2014 ,The Pediatric Infectious Disease Journal,Immunogenicity and Safety of a Heptavalent Infant Vaccine,This study investigates the efficacy and safety of a heptavalent combination vaccine for infants to include protection against meningococcal serogroup C.
  December 2014 ,Prostate Cancer and Prostatic Diseases,Variables Associated With Bone Biopsy Tumor Yield in mCRPC,"Certain variables may impact tumor yield on image-guided bone biopsy in mCRPC. Find out what they are, and which strategies may increase tumor acquisition."
" Open Access Journal of Plastic Surgery,  December 2014 ",ePlasty,"Infections, Antibiotic Duration in ADM Breast Reconstruction",This new article examines the infection rates in ADM-assisted breast reconstruction and the associated antibiotic regimens.
  December 2014 ,Critical Care,Mortality After RBC Transfusion or Inotropes in Septic Shock,"Find out what kind of punch red blood cells pack, when it comes to treatment for septic shock."
  December 2014 ,Current Opinion in Allergy and Clinical Immunology,Novel Immunotherapy Approaches to Food Allergy,Learn more about how immunotherapy comes to the rescue -- when food is the enemy.
  December 2014 ,European Heart Journal,Heart Failure in Younger Patients,How do younger patients with heart failure differ from their older counterparts?
  December 2014 ,Arthritis Research & Therapy,Ultrasound Assessment of Pathologies in Psoriatic Arthritis,Is an ultrasound assessment useful in the diagnosis of inflammatory and structural pathologies in psoriatic arthritis?
  December 2014 ,Cardiovascular Diabetology,Triglycerides Predict Ten-Years All-Cause Mortality in T2DM,Are high triglyceride levels associated with CV risk and mortality in patients with type 2 diabetes?
  December 2014 ,Future Microbiology,40 Years of Progress in Bone Marrow Transplantion,"A brief synopsis of topics covered at the annual meeting of the European Society for Blood and Marrow Transplantation, including the latest on stem cell transplantation, fungal infection, and more."
  December 2014 ,International Journal of Clinical Practice,Sorting Out Weight Loss Agents,"Numerous pharmaceutical interventions are available to treat obesity, including some just recently approved. How should you choose what's best for your patient?"
  December 2014 ,Annals of Oncology,Circulating Tumor Cells and Circulating Tumor DNA for Precision Medicine,"Get the most important recent findings in the CTC field, focusing on challenges and opportunities in moving these tools forward in clinical practice."
  January 2015 ,Neurosurgical Focus,Stereotactic Laser Ablation of High-Grade Gliomas,"Laser interstitial thermal therapy promises new hope for the treatment of high-grade gliomas. In this review, the authors present a management algorithm that incorporates LITT in clinical practice."
  January 2015 ,Laboratory Investigation,Downregulation of Spleen TK in Hepatocellular Carcinoma,The authors explore the role of spleen tyrosine kinase expression in hepatocellular carcinoma. Might it act as a tumor suppressor in HCC cells?
  January 2015 ,Eye,OCT for the Diagnosis of Neovascular AMD,Is OCT a reliable diagnostic tool for assessing patients with suspected neovascular AMD?
  January 2015 ,U.S. Pharmacist,Onychomycosis: Clinical Considerations and Recommendations,How long should antifungals be given for onychomycosis? Is monitoring necessary?
  January 2015 ,Journal of the American College of Cardiology,Net Benefit of Antithrombotic Therapy in AF and CKD,How does antithrombotic therapy reduce risk in patients with these 2 comorbidities?
  January 2015 ,BMC Gastroenterology,Intestinal Permeability -- A New Target for Disease,What does the latest research tell us about the clinical significance of the intestinal barrier and intestinal permeability for health and disease?
  January 2015 ,Future Oncology,Cardiovascular Toxicities and Tumors Treated With Sorafenib,"Is sorafenib associated with a higher risk of developing all grade hypertension and bleeding, when compared with controls?"
  January 2015 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Stimulant Use and AIDS Progression After HAART,Are HIV+ stimulant users at an elevated risk for more rapid HIV disease progression even after the initiation of HAART?
  January 2015 ,Future Neurology,Neuroimaging Chronic Pain: What Have We Learned?,How does the brain work in the presence of chronic pain?
  January 2015 ,BMC Clinical Pathology,Estrogen and Androgen Receptor in Liposarcoma,"Might hormonal receptor expression be a factor in liposarcoma, as it is in other cancers such as breast and prostate cancer?"
  January 2015 ,The American Journal of Gastroenterology,"Biosimilars: The Need, The Challenge, The Future","What are biosimilars, how are they developed, and how are they poised to change the way diseases are treated in the future?"
  January 2015 ,OJIN: The Online Journal of Issues in Nursing,Value of Information Services in Nursing and Patient Care,Libraries provide essential resources for literature searches and access to open source and other forms of research based knowledge in healthcare settings.
  January 2015 ,Nanomedicine,Macrophages and CNS Delivery of Therapeutic Proteins,The authors report on novel nanoformulations of nanozymes utilizing macrophages as transporters with the ability to cross the blood-brain barrier for treatment of CNS diseases.
  January 2015 ,BMC Public Health,Delivery of the HPV Vaccine Through a School-Based Program,"This study indicates that the availability of HPV vaccination through a free, school-based program is an effective delivery method--but is it sufficient for ensuring high HPV vaccine coverage?"
  January 2015 ,Neurosurgical Focus,Contemporary Health Care Economics: An Overview,"While much focus is put on health care economics, few clinicians really understand the methods and concepts behind economic evaluation and cost analysis. Learn the basics in this primer."
  January 2015 ,Headache,Clinical Characteristics of Trigeminal Neuralgia,"This study suggests that symptomatology of trigeminal neuralgia consists not only of classic severe stabbing neuropathic facial pain, but may include accompanying autonomic and sensory abnormalities."
  January 2015 ,Cardiovascular Diabetology,Obesity Attenuates Gender Differences in CV Mortality,How does gender affect cardiovascular disease mortality in obese patients? Who's at higher risk... Men or women?
  January 2015 ,BMC Pulmonary Medicine,"Nonspecific Interstitial Pneumonia: Associations, Outcomes",Is idiopathic NSIP a first manifestation of an underlying systemic autoimmune disease?
  December 2014 ,U.S. Pharmacist,Gender Differences in Pharmacokinetics,Why are doses of zolpidem reduced in women? Learn how metabolism of some medications may be affected by gender.
  December 2014 ,Diabetes Care,Association of Diabetic Retinopathy With Cognitive Function,Are patients with diabetic retinopathy at risk for cognitive decline?
  January 2015 ,Cardiovascular Diabetology,Cardiovascular Effects of GLP-1 Receptor Agonists,Are GLP-1 receptor agonists 'cardiac friendly'?
  January 2015 ,Nanomedicine,Rational Design of Gold Nanoparticle Toxicology Assays,How toxic are gold nanoparticles? This article aims to provide general guidelines for nanotoxicological assays of AuNPs.
  January 2015 ,Annals of Surgery,Contralateral Mastectomy After Unilateral Breast Cancer,This study assess contralateral prophylactic mastectomy outcomes in women with unilateral breast cancer.
  January 2015 ,Journal of Pediatric Psychology,Behavioral Intervention to Decrease Obesity in Preschoolers,This study evaluated an 18-session family-based behavioral intervention which addressed the unique challenges of obesity in preschoolers.
  January 2015 ,Current Opinion in Gastroenterology,The Gut Microbiome in Health and in Disease,"As researchers begin to learn more about the gut microbiome, how are they better understanding its connection to the development of certain diseases?"
  January 2015 ,Journal of the National Cancer Institute,Breast Cancer Screening and Overdiagnosis Estimates,"Identifying which breast cancer estimates are reliable is challenging, but now there's an approach that provides a system of checks and balances."
  January 2015 ,Clinical Lipidology,Are Add-on to Statins Needed in Hypercholesterolemia?,"Does combining a statin with a bile acid sequestrant, fibrate or ezetimibe reduce LDL-C and improve glycemic control in patients with diabetes?"
  January 2015 ,Annals of Cardiothoracic Surgery,Mechanical Circulatory Support Devices as Destination Therapy,Is mechanical support the wave of the future -- for older and sicker patients ineligible for heart transplant?
  January 2015 ,American Heart Journal,Reduction in Stroke and Thromboembolic Events in AF,Find out about events after blinded study drug discontinuation and transition to open-label vitamin K antagonist -- in ARISTOTLE.
  January 2015 ,Clinical Endocrinology,Adverse Skeletal Effects of Drugs -- Beyond Glucocorticoids,Drugs of all types may increase fracture risk. Which ones are you prescribing?
  January 2015 ,Urologic Nursing,Pre-Operative Pelvic Floor Muscle Training -- A Review,Do most men benefit from pelvic floor exercises before surgery?
  January 2015 ,Chinese Clinical Oncology,The Distinctive Features of Surgical Oncology as a Specialty,Find out how cancer care is evolving from a generalized single provider mode toward a more personalized team approach.
  January 2015 ,The British Journal of Dermatology,Itching and Quality of Life for Patients With Psoriasis,Pruritus is one of the most prevalent symptoms in patients with psoriasis. What role does it play in mediating the relationship between improvements in disease severity and HRQOL?
  January 2015 ,Journal of Cardiovascular Electrophysiology,Amiodarone in AF With and Without LV Dysfunction,Is amiodarone's efficacy in maintaining sinus rhythm and reducing the AF burden similar regardless of whether patients have severe LV dysfunction or not?
  January 2015 ,Current Opinion in Nephrology and Hypertension,Optimal Targets for Blood Pressure Control in CKD,"Which antihypertensive medications are most effective for patients with advanced CKD, and do clinicians generally agree upon optimal targets for blood pressure control in this subset of patients?"
  January 2015 ,OJIN: The Online Journal of Issues in Nursing,Clinical Nurse Preceptors and Intra-Professional Collaboration,"Graduate nursing preceptors are essential to meet the projected healthcare needs of the future, with wisdom and professionalism."
  January 2015 ,Translational Andrology and Urology,Kidney Stone Risk Following Roux-en-Y Gastric Bypass Surgery,"Find out about the potential risk factors for kidney stone development after Roux-en-Y gastric bypass surgery, and recommendations for reducing the risk."
  January 2015 ,Cardiovascular Diabetology,Relation of Overall & Abdominal Adiposity to Vascular Health,What is the impact of overall obesity on vascular atherosclerotic changes?
  January 2015 ,International Journal of Clinical Practice,Suvorexant for Insomnia: Efficacy and Safety Profile,Suvorexant is the first orexin receptor antagonist approved for the treatment of insomnia. What do you need to know before prescribing?
  January 2015 ,Annals of Oncology,Prognostic Value of Kras Mutations in Stage Iii Colon Cancer,Find out more about the pronostic impact of KRAS exon 2 mutations in stage III colon cancer.
  January 2015 ,International Journal of Clinical Rheumatology,Rapid Crystal Dissolution in Gout,Does more rapid crystal dissolution have any clinical relevance for gout patients?
  January 2015 ,Current Opinion in Allergy and Clinical Immunology,Sublingual Immunotherapy in Children: Recent Experiences,Learn more about sublingual immunotherapy in pediatric patients suffering from allergic rhinitis or allergic rhinoconjunctivitis caused by environmental allergens.
  January 2015 ,Future Virology,Antiviral Therapy in the Hepatitis C Virus Life Cycle,What are the recent advances in our understanding of the HCV life cycle and how have they impacted antiviral therapy?
  January 2015 ,BMC Oral Health,Antimicrobial Photodynamic Therapy Suppresses Dental Plaque,Is antimicrobial photodynamic therapy a safe and effective alternative to mechanical approaches for daily plaque control?
  January 2015 ,BMC Anesthesiology,Cardiac Condition During Therapeutic Hypothermia After CPR,"Patients may benefit neurologically from therapeutic hypothermia, but could this therapy also improve cardiac function?"
  January 2015 ,Personalized Medicine,Where Is Personalized Medicine in Cancer Heading?,Learn why molecular imaging is a very promising aspect of personalized medicine for cancer care.
  January 2015 ,Future Oncology,Third- and Further-line Therapy in Advanced NSCLC Patients,"Although the benefit of first- and second-line treatment over best supportive care alone has been firmly established, the role of further-line treatment remains controversial. . ."
  January 2015 ,BMC Musculoskeletal Disorders,An Outcome Prediction Tool for Patients Considering TKA,"In this paper, the development of a prediction tool based on patient factors for outcomes after knee replacement surgery is described."
  January 2015 ,Liver International,Current and Future HCV Therapy,"Interferon-free regimens for hepatitis C have made treatment shorter, safer, and more effective; yet, certain areas require further evaluation to make this possible and cost-effective for all."
  January 2015 ,Cardiovascular Diabetology,Association of SFRP4 With T2D in Patients With Stable CAD,Do these regulators of Wnt-signaling predict cardiovascular outcome in patients with CAD?
  January 2015 ,Annals of Oncology,Molecular Subtype of Breast Cancer Metastases,Do tumor characteristics and molecular subtypes in breast cancer metastases confer clinically relevant prognostic information for patients?
  January 2015 ,Pharmacogenomics,Personalized Sequencing and the Future of Medicine,Advances in the speed and scale of DNA sequencing means it's now practical to produce personalized clinical evaluations. What impact will this have on pharmacogenomics and medicine as a whole?
  January 2015 ,Clinical Endocrinology,Drugs That Interact With Levothyroxine,Which prescription drugs and dietary supplements significantly affect TSH in patients taking levothyroxine?
  January 2015 ,Rheumatology,Low-dose Glucocorticoid Treatment in the Patient With RA,How safe are low-dose glucocorticoids when used long term for the management of rheumatoid arthritis?
  January 2015 ,BMC Gastroenterology,The Changing Clinical Profile of Celiac Disease,How has understanding the clinicopathological aspects of celiac disease helped to shape patient care over the last couple of decades?
  January 2015 ,Medicine and Science in Sports and Exercise,Sex Differences and Effects of T2DM on Exercise Performance,How does exercise performance compare between men and women with type 2 diabetes? This study investigates.
  January 2015 ,Future Oncology,Dosage Escalation of Sorafenib in Metastatic RCC,Is subsequent dosage escalation of sorafenib effective for patients with advanced renal cell carcinoma?
  January 2015 ,Current Opinion in Rheumatology,An Update on Intestinal Behcet's Disease,"What recent developments have been made in the diagnosis, treatment, and prognosis of intestinal Behcet's disease?"
  January 2015 ,The American Journal of Gastroenterology,Risk Factors for Barrett Esophagus,"Are African Americans more likely to develop Barrett esophagus than non-Hispanic Whites and, if so, what are the reasons?"
  January 2015 ,Current Opinion in Infectious Diseases,What's New in the Treatment of Serious MRSA Infection?,This article reviews several new MRSA-active agents now approved for use.
  February 2015 ,Journal of the American College of Cardiology,Aspirin Use for Primary Prevention of Cardiovascular Disease,How common is inappropriate aspirin therapy use in primary prevention?
  February 2015 ,Future Oncology,Cancer Stem Cells: Responsible for Treatment Failure?,Novel animal models may lay the foundation for a new generation of clinical trials aimed at anticipating the benefit to patients of anticancer therapies.
  February 2015 ,Malaria Journal,Topical Insect Repellents in Endemic Malaria Populations,Do topical insect repellents reduce outdoor biting and morbidity from malaria?
  February 2015 ,Liver International,IFN-free Therapy in Treatment-naive Patients With HCV,"What therapies, approved and on the horizon, exist to treat treatment-naive patients with hepatitis C?"
  February 2015 ,Personalized Medicine,10 Years of Personalizing Medicine: Practice and Policy,What challenges are ahead for the next decade of personalized medicine?
  January 2015 ,Alimentary Pharmacology & Therapeutics,HCV Infection and Post-liver Transplant Diabetes,"Hepatitis C virus is known to be associated with metabolic manifestations including insulin resistance and diabetes, but could it also increase the risk of post-transplant diabetes?"
  January 2015 ,Nutrition and Metabolism,Pharmacological Potential of Tocotrienols: A Review,"Is this lesser-known form of vitamin E a ""wonder drug""?"
  January 2015 ,BMC Public Health,Varenicline vs. Nicotine Replacement for Smoking Cessation,Which is more effective for quitting smoking in real-world use: nicotine replacement or varenicline?
  January 2015 ,European Heart Journal,"HDL Cholesterol Subclass, MI and Mortality in Prevention",What are the connections between HDL subclasses and prognosis in secondary prevention for coronary heart disease?
  January 2015 ,Current Opinion in Neurology,Disorders of Emotional Processing in ALS,"This review summarizes recent research suggesting that emotional processing dysfunction is common in ALS, including impaired recognition of facial expression and problems with social cognition."
  January 2015 ,Prostate Cancer and Prostatic Diseases,Bone Complications Among Prostate Cancer Survivors,Long-term use of ADT may be associated with an increased risk of fracture in men with prostate cancer.
  January 2015 ,Seminars in Neurology,Rehabilitation of Poststroke Cognition,"By means of a case example, the authors discuss approaches to cognitive rehabilitation in stroke, focusing on speech and language, functional memory, executive function, and spatial-motor systems."
  January 2015 ,BMC Psychiatry,Management for Treatment-Resistant Depression in Adolescents,This review explores the optimal pharmacological and psychosocial interventions for adolescents who do not adequately respond to initial treatment for depression.
  January 2015 ,Newborn & Infant Nursing Reviews,A Practical Method for Rapid Measurement of Skin Condition,"Get an overview of skin breakdown in hospitalized infants along with a validated, visually based method for rapid measurement of skin condition."
  January 2015 ,Brain,Vision and Vision-related Outcome Measures in MS,"This article presents an overview of vision-associated symptoms in multiple sclerosis, highlighting the importance of vision as a model for outcomes assessment in clinical trials."
  January 2015 ,Schizophrenia Bulletin,Efficacy of a Smartphone Intervention for Schizophrenia,A novel smartphone intervention designed to support self-management of schizophrenia can reduce costs and extend the reach of care beyond the clinician's office.
  January 2015 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,"EMS Public Health Implications, Interim Guidance for Ebola",Are you prepared to care for a patient with suspected Ebola? Find out the recommended strategies for pre-hospital providers to prevent the spread of infection.
  January 2015 ,Clinical Endocrinology,Adrenal Insufficiency: Outcomes With Glucocorticoid Therapy,Can we manage adrenal insufficiency better? Which aspects of glucocorticoid therapy need improving?
  January 2015 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Nevirapine to Rilpivirine Switch in Suppressed HIV,Is substituting nevirapine for rilpivirine safe and effective in virologically suppressed HIV patients?
  January 2015 ,Wounds,Hypochlorous Acid: An Ideal Wound Care Agent With Potency,What's the effect of stabilized hypochlorous acid solution on chronic wound healing?
  February 2015 ,Future Oncology,Palonosetron for Emesis Control in High-dose Chemotherapy,Find out how a second-generation 5-HT3RA impacts chemotherapy-induced nausea and vomiting associated with anti-cancer chemotherapy.
  February 2015 ,HIV Medicine,Expression of Gut-homing B7 Receptor on T Cells,This article analyzes microbial translocation and expression of the gut-homing B7 receptor on peripheral T cells in HIV-1-infected individuals.
  February 2015 ,Liver International,IFN-free Therapy in Treatment-experienced Patients With HCV,Treatment-experienced patients with chronic hepatitis C can now benefit from interferon-free regimens. What are they?
  February 2015 ,Translational Andrology and Urology,The Utility of Testicular Prosthesis Placement in Children,Can testicular prostheses be safely and effectively placed in pediatric patients with testicular disorders?
  February 2015 ,Alimentary Pharmacology & Therapeutics,"Food Intolerance: Etiology, Diagnosis, Mechanisms, Evidence",How does this new article advance our understanding of how certain foods or food components could be implicated in cases of food intolerance?
  February 2015 ,Endocrine Practice,Insulin Pump Programming: Preventing Dawn Phenomenon in T1D,Is delivery of a fixed increase of early morning insulin a safe or hazardous practice?
  February 2015 ,Annals of Oncology,Challenges in Combining Novel Molecularly Targeted Agents,Find out why combining novel molecularly targeted agents is probably one of the most critical and complex challenges in cancer medicine today.
  February 2015 ,Breast Cancer Research,CTCs as Predictors of Metastatic Spread in Breast Cancer,Find out about the role of CTC counts as predictors of disease evolution in breast cancer patients with limited metastatic dissemination.
  February 2015 ,Pharmacogenomics,The Promise of Pharmacogenomics for Inflammatory Diseases,Many patients don't adequately respond to treatment with drugs used in inflammatory diseases. Could predictive biomarkers to drug response--both genetic and non-genetic--be identified?
  February 2015 ,European Heart Journal,Carotid Artery Stenting: An Update,"Get current on the major technology advancements in carotid artery stenting, and peek into a crystal ball for glimpses of its' future."
  February 2015 ,Future Cardiology,Challenges in Cardiology Research in Pregnancy,"Find out why CV research in pregnancy is both doubly challenging and rewarding, as it involves a special 'vulnerable' group."
  February 2015 ,BMC Psychiatry,Atypical Antipsychotics in SSRI Treatment Refractory OCD,Which--if any--antipsychotics are effective in augmenting SSRI therapy in treatment refractory obsessive-compulsive disorder?
  February 2015 ,Future Virology,Dolutegravir: A New HIV Integrase Inhibitor,"Read about dolutegravir, the most recent antiretroviral approved for treatment of HIV-1 infection."
  February 2015 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Utility of Vital Signs in Mass Casualty-Disaster Triage,Could vital signs play a role in improving the accuracy of triage categorization during a mass casualty-disaster event?
  February 2015 ,Morbidity & Mortality Weekly Report,"Estimates of Seasonal Flu Vaccine Effectiveness, Jan 2015",Early estimates suggest that the 2014-15 influenza vaccine has low effectiveness against circulating influenza A viruses--but vaccination is still recommended.
  February 2015 ,Journal of Perinatology : Official Journal of the California Perinatal Association,Lower Vitamin D Levels and Neonatal Sepsis in Term Infants,What role does vitamin D play in the prevention of early-onset neonatal sepsis?
  February 2015 ,Cancer Control: Journal of the Moffitt Cancer Center,Current and Emerging Therapies for Bone Metastatic CRPC,Find out more about new therapies that show promise in improving overall survival rates in patients with bone metastatic castration resistant prostate cancer.
  February 2015 ,Rheumatology,Use of Ultrasound in Assessing Disease Activity in RA,Can ultrasound replace clinical examination for the assessment of disease activity in rheumatiod arthritis?
  February 2015 ,Nanomedicine,Nanotechnology for Cancer Nanoimmunotherapy,Immunotherapy is a promising option for cancer treatment. How might nanocarriers be utilized for antitumor nanoimmunotherapy?
  February 2015 ,Journal of Cardiovascular Electrophysiology,Caffeine in Patients With SVT Undergoing EP Studies,What's the impact of caffeine on supraventricular tachycardia induction?
  February 2015 ,BMC Neurology,Effect of Peginterferon Beta-1a on MRI Measures in RRMS,This study explored the effect of peginterferon beta-1a every 2 and 4 weeks on MS disease activity as measured by brain lesions detected on MRI. How did it perform against placebo?
  February 2015 ,International Journal of Impotence Research,Psychosocial Outcomes After Tadalafil or Sildenafil for ED,This study examines the psychosocial effect of these three pharmacologic treatment strategies for ED. How do they compare?
  February 2015 ,Future Oncology,Hypoxic Tumor Microenvironment: Driving NSCLC Tumorigenesis,Find out about recent advances in our understanding of how a complex milieu of supporting cells impact the tumor response to hypoxia in NSCLC.
  February 2015 ,AIDS,Dolutegravir Efficacy in Treatment-Naive HIV Patients,Is dolutegravir effective as a first-line antiretroviral therapy in HIV-positive individuals?
  February 2015 ,Personalized Medicine,Incorporating Personalized Medicine Into Healthcare,Will personalized medicine exacerbate disparities in health care?
  February 2015 ,Age and Ageing,Management of Fracture Risk in Patients With Parkinson's,Patients with Parkinson's disease have an increased risk of falls and fractures. How should fracture risk assessment and bone health be managed in Parkinson's patients?
  February 2015 ,Annals of Cardiothoracic Surgery,Present and Future Perspectives on Total Artificial Hearts,Shortages in donor organ availability put advanced heart-failure patients at high risk of further decompensation and often death while awaiting transplantation. Learn how far artificial hearts have come in closing the gap.
  February 2015 ,Cardiovascular Diabetology,Chemerin Is a Biomarker of ACS but not Angina Pectoris,Are levels of this novel adipokine increased in patients with ACS or stable angina pectoris?
  February 2015 ,International Journal of Clinical Practice,Pain Management in Internal Medicine,This study examined the prevalence of pain and its treatment in hospitalized patients on internal medicine wards. Is pain management being adequately and appropriately used in this setting?
  February 2015 ,European Heart Journal,Prognostic Role of Restenosis in Angiography After Stenting,What's the impact of restenosis on 4-year mortality in patients undergoing routine control angiography after coronary stenting?
  February 2015 ,Nanomedicine,Chemotherapy vs. Nanotherapy for Recurrent Ovarian Cancer,"Nanotherapies may reducing toxicity of treatment for advanced or recurrent ovarian cancer, but are they also cost-effective as compared to standard chemotherapy?"
  February 2015 ,Medicine and Science in Sports and Exercise,Muscle Oxygen Supply Impairment During Exercise in T1DM,Find out the ways in which muscle oxygen supply during exercise is impacted in individuals with poorly controlled T1DM.
  February 2015 ,Chinese Clinical Oncology,"Clinical Trials in Lung Cancer Surgery, Research Cooperation","Get a wide-angle view of lung cancer research, from a country with an ever growing population of lung cancer patients."
  February 2015 ,Schizophrenia Bulletin,Recovery in Psychosis: A Delphi Study,Just what does recovery from psychosis mean? This study aims to identify areas of consensus in relation to definitions of recovery from a patient perspective.
  February 2015 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Assessing PrEP Adherence/Exposure Using Hair Samples,Is measuring exposure in small hair samples an accurate way to assess HIV PrEP adherence?
  February 2015 ,The American Journal of Gastroenterology,Quality Indicators for Colonoscopy,"Colonoscopy is widely used to diagnose and treat colon disorders. How successful is it, and in what particular situations is it most warranted?"
  February 2015 ,BMC Neurology,Alzheimer's Disease and Cancer: What Are the Implications?,"Recent studies have indicated that patients with Alzheimer's show a reduced risk of cancer, while cancer survivors are less likely to develop AD. What underlying mechanisms might explain this?"
  February 2015 ,BMC Anesthesiology,PaO2/FiO2 Ratio After Cardiac Surgery to Predict Outcome,Can the PaO2/FiO2 ratio be used to predict mortality in patients immediately after cardiac surgery?
  February 2015 ,Nanomedicine,Nanomedicine Strategies for Hematological Malignancies,This review focuses on how nanoparticles could help the hematologist in diagnosing and treating patients during everyday clinical practice.
  February 2015 ,American Journal of Critical Care,Body Temperature and Mortality in Patients With ARDS,Should clinicians routinely intervene to suppress fever in critically ill patients?
  February 2015 ,The British Journal of Dermatology,Screening of Individuals at High Risk of Cutaneous Melanoma,Are existing guidelines for the screening and follow-up of patients at high risk for cutaneous melanoma adequate? This review makes recommendations for improving the quality of current guidelines.
  February 2015 ,Alimentary Pharmacology & Therapeutics,Breath Analysis in Inflammatory Bowel Diseases,Are there breath analysis testing methods that could help clinicians to better diagnose and ultimately treat IBD?
  February 2015 ,Nephrology Dialysis Transplantation,The Kidney Biopsy in Lupus Nephritis,"Besides the kidney biopsy, which has traditionally been the gold standard for the diagnosis of lupus nephritis, what other options are available to clinicians?"
  February 2015 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,"Hemodynamic Monitoring in Heart Failure, Sepsis and Stroke",A new study examines the potential role of noninvasive hemodynamic assessments in these critically ill ED patients.
  February 2015 ,Journal of the National Cancer Institute,Aspirin and COX-2 Inhibitor Use in Stage III Colon Cancer,Are aspirin and COX-2 inhibitors improving outcomes in stage III colon cancer patients?
  February 2015 ,European Heart Journal,FFR vs Angiography in Optimizing Outcomes in NSTEMI,Is angiography-guided management associated with higher rates of coronary revascularization when compared with FFR-guided management in NSTEMI patients?
  February 2015 ,Cardiovascular Diabetology,Prediction of Mortality Using a Vascular Calcification Score,Which calcified plaque scores best predict all-cause mortality in patients with type 2 diabetes?
  February 2015 ,Annals of Oncology,Prevention of Skeletal Complications in Metastatic CRPC,Learn more about the efficacy of denosumab use for prevention of skeletal complications in patients with CRPC.
  February 2015 ,The Hospitalist,10 Things Oncologists Think Hospitalists Need to Know,Cancer patients can be some of the most challenging who come into a hospitalist's care. These 10 tips from oncologists may help.
  February 2015 ,Seminars in Respiratory and Critical Care Medicine,Interventional Pulmonology for Asthma and Emphysema,Sharpen your knowledge of bronchoscopic modalities for emphysema and asthma.
  February 2015 ,Current Opinion in Rheumatology,Epigenetics in Rheumatoid Arthritis,What role do epigenetic factors play in the pathogenesis of rheumatoid arthritis?
  February 2015 ,Journal of Pediatric Health Care,Tobacco Exposure Among Youth Undergoing Cancer Treatment,Are pediatric cancer patients more or less likely to be exposed to tobacco during treatment?
  February 2015 ,Future Virology,Human Papillomavirus Vaccination for Men,Most HPV vaccination programs focus on and cover the cost of vaccination for girls only. Would it be cost-effective to promote HPV vaccine uptake for boys as well?
  February 2015 ,BMC Surgery,Gastrointestinal Stromal Tumor,This study explores the characteristics and prognostic factors of GIST.
  February 2015 ,The American Journal of Gastroenterology,Treatment of IBD: Where We Are and Where We Are Going,This new article sheds light on some of the newer therapies on the horizon to treat IBD. How do they differ from older drug regimens?
  February 2015 ,BMC Family Practice,Antibiotic Prescribing for Acute Bronchitis,Are primary care physicians disregarding treatment guidelines concerning antibiotic use in acute bronchitis?
  February 2015 ,BMC Oral Health,Provision of Specific Dental Procedures By General Dentists,How often do general dentists provide specific dental procedures? The findings of this study may have implications for the changing picture of dental economics and dental care utilization.
  February 2015 ,Current Opinion in Infectious Diseases,Optimizing Therapy for VRE Bacteremia in Children,Which drug is most optimal for the treatment of vancomycin-resistant enterococcal bloodstream infections in children?
  February 2015 ,American Journal of Public Health,Prescription Drug Insurance Coverage and Patient Outcomes,Can expanding prescription drug insurance benefits reduce use of other health care services and positively impact patient outcomes?
  February 2015 ,BMC Anesthesiology,Simulation-Based Axillary Brachial Plexus Blockade,How effective is simulator based training for novice anesthesiologists to learn ultrasound-guided axillary brachial plexus blockade?
  February 2015 ,European Heart Journal,Effects of HDL Mimetic Agent CER-001 on Atherosclerosis in ACS,Does CER-001 have protective vascular effects like HDLs - in patients with acute coronary syndromes?
  February 2015 ,Cardiovascular Diabetology,Hypertriglyceridemia: A Neglected Major CV Risk Factor,Why is management of hypertriglyceridemia challenging? Which strategies work?
  February 2015 ,Environmental Health Perspectives,Indoor Environmental Exposures and Exacerbation of Asthma,This review provides a comprehensive update on specific indoor environmental exposures which might cause exacerbation of asthma.
  February 2015 ,International Journal of Clinical Practice,"Vilazodone, Levomilnacipran and Vortioxetine for MDD","Three new agents have recently been approved for the treatment of major depressive disorder. What are the differences between them, and how should you chose which is best for your patient?"
  February 2015 ,Critical Care Medicine,Fluid Management With Simplified Conservative ARDS Protocol,"Compare the performance of FACTT Lite, FACTT Conservative, and FACTT Liberal protocols."
  February 2015 ,Journal of Glaucoma,Superior vs Inferior Glaucoma Drainage Device Implantation,How do these two locations for device implantation placement compare in terms of IOP control and postoperative complications?
  February 2015 ,Skin Therapy Letter,5% Minoxidil: Treatment for Female Pattern Hair Loss,"Until recently, the only FDA-approved medication for female pattern alopecia was 2% minoxidil solution, but in 2014 a 5% minoxidil foam became an option. What do you need to know?"
  February 2015 ,BMC Psychiatry,Second Generation Antipsychotics for Bipolar Disorder,There are several second-generation antipsychotics approved for bipolar disorder. What factors influence providers' decisions to prescribe SGAs for these patients?
  February 2015 ,The Journal of Invasive Cardiology,Outcomes of Infrainguinal Peripheral Artery Interventions,Get up-to-date on contemporary use of stent and non-stent based treatment strategies for PAD.
  February 2015 ,Brain,Targeting Pharmacoresistant Epilepsy and Epileptogenesis,"This study investigates the novel antiepileptic drug eslicarbazepine, which possesses properties that may allow it to overcome cellular mechanisms of pharmacoresistance in epilepsy."
  February 2015 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Bedside US as an Adjunct for Acute Appendicitis in the ED,Is bedside ultrasound an effective diagnostic tool in assessing patients with suspected appendicitis in the ED?
  February 2015 ,The American Journal of Gastroenterology,Quality Indicators for EGD,What types of diseases can best be diagnosed and treated with EGD? This new article explains.
  February 2015 ,American Journal of Pharmaceutical Education,Predatory Publishing and Questionable Peer Review,Why is the open-access concept being exploited? Do you know how to avoid these unethical practices?
  February 2015 ,Women's Health,Uterine Fibroids Associated With Infertility,What is the best way to manage uterine fibroids in patients with infertility? Are there special considerations?
  February 2015 ,Diabetes Care,Microvascular Complications and Foot Care,"Read the American Diabetes Association recommendations for screening and management of diabetic retinopathy, nephropathy, neuropathy, and foot care."
  February 2015 ,BMC Neurology,Donepezil for Severe Alzheimer's Patients in Long-term Care,Can cholinesterase inhibitors used in conjunction with psychosocial interventions have clinically positive effects for patients with severe Alzheimer's disease?
  February 2015 ,Spine,Sedimentation Sign and Spinal Stenosis Treatment Effect,"A positive sedimentation sign on MRI could be an indicator of a larger surgical treatment effect in patients with lumbar spinal stenosis, a new study reports."
  February 2015 ,Europace,Non-vitamin K Antagonist Agents in Anticoagulant Naive AF,What are the contemporary patterns of oral anticoagulation (OAC) use in patients with AF -- who weren't previously on OACs?
  February 2015 ,Future Oncology,The Promise of Combining Radiation Therapy and Immunotherapy,Radiation therapy and immunotherapy in partnership may have the capability of delivering a therapeutic effect exceeding the sum of its parts.
  February 2015 ,Future Microbiology,Effect of Magnetic Fields on Cystic Fibrosis Pathogens,Could exposure to extremely low frequency magnetic fields influence growth and biofilm formation by pathogens which cause chronic lung infections in cystic fibrosis patients?
" Open Access Journal of Plastic Surgery,  March 2015 ",ePlasty,The WoundWand and Its Novel Use in Burn Excision Surgery,This novel surgical ablative tool could play an important role in the future of burn surgery.
  March 2015 ,Europace,RFA as Initial Therapy in Paroxysmal Atrial Fibrillation,Find out about the longer term effect of RFA on Health-Related Quality of Life and symptom burden of patients.
  March 2015 ,Wounds,Palliative Wound Treatment Promotes Healing,"Pain, infection, and odor, often make wound care difficult. Learn new ways to manage end-of-life wounds."
  March 2015 ,Future Microbiology,Gene Silencing: Combatting Influenza Virus Infections,Could gene silencing technologies such as RNA interference and nucleic acid enzymes have therapeutic potential against the influenza virus?
  March 2015 ,European Heart Journal,Masked Uncontrolled Hypertension in Patients Treated for HTN,"How ""MUCH"" masked uncontrolled hypertension occurs in patients who are treated for hypertension?"
  March 2015 ,Journal of the American Geriatrics Society,AGS Guideline for Postoperative Delirium in Older Adults,"The AGS presents recommendations providing essential guidance on the prevention of postoperative delirium in older patients, as well as the treatment of elderly surgical patients with delirium."
  March 2015 ,BMC Public Health,Nicotine Replacement Therapy Use Among Smokers and Ex-Smokers,This study investigated beliefs and concerns regarding nicotine replacement therapy among tobacco users. What are the barriers and facilitators of the use of medicinal nicotine from their perspective?
  March 2015 ,BMC Pregnancy and Childbirth,Can a Text Message a Week Improve Breastfeeding?,"While breastfeeding is universally acknowledged as the optimal method for feeding infants, rates in some places remain low. Could a text message help improve rates?"
  March 2015 ,Cardiovascular Diabetology,Asymmetric Dimethylarginine and Adverse CV Events in T2D,Can this biomarker predict risk of adverse CV events in patients with diabetes?
  March 2015 ,American Heart Journal,Changes in Mid-life Fitness and HF Risk at a Later Age,Is mid-life fitness enough to reduce HF hospitalization at a later age?
  March 2015 ,Nanomedicine,Nanobody-Based Cancer Therapy of Solid Tumors,"Tumor-targeted therapies using monoclonal antibodies has revolutionized cancer chemotherapy, but challenges still exist. How might nanobody-based therapeutics overcome these limitations?"
  March 2015 ,Laboratory Investigation,Two-Dimensional Culture of Pancreatic Adenocarcinoma Cells,"The authors present new methods for the culture of human pancreatic ductal adenocarcinoma cells from murine xenografts of human tumors, which could replace overused commercial cell lines."
  March 2015 ,BMC Ophthalmology,Selective Laser Trabeculoplasty for Normal Tension Glaucoma,"At twelve months, patients with normal tension glaucoma sustained IOP reduction and less medication use after one session of selective laser trabeculoplasty."
  March 2015 ,Future Virology,Hepatitis C Virus: Strategies to Evade Antiviral Responses,This articles examines the processes and proteins used by HCV to evade and regulate host innate immunity.
  March 2015 ,Journal of the American Board of Family Medicine,Improvement in Lung Cancer Outcomes With Targeted Therapies,"Primary care physicians play an important role in the treatment, detection, and management of common toxicities associated with targeted chemotherapy for lung cancer. What do you need to know?"
  March 2015 ,Liver International,Cirrhosis Regression in HCV Patients After Antiviral Therapy,Do the majority of patients with cirrhosis who achieve a sustained virological response develop cirrhosis regression? This new study investigates.
  March 2015 ,Liver International,Appraising Cardiac Dysfunction in Liver Transplantation,How can clinicians best monitor cardiac dysfunction in patients with end-stage liver disease?
  February 2015 ,Prostate Cancer and Prostatic Diseases,Who Dies From Prostate Cancer?,Gain a better understanding of the characteristics and mortality patterns of patients who died of prostate cancer.
  February 2015 ,International Journal of Clinical Rheumatology,Systemic Lupus Erythematosus: Which Drugs and When?,Treatment options for SLE are continuing to improve. Which therapies are most promising?
  February 2015 ,Kidney International,The Definition of AKI and Its Use in Practice,"How can a universal definition of acute kidney injury help clinicians both gain a better understanding of the disease, and assist them in treating patients?"
  March 2015 ,Annals of Family Medicine,Pharmacological Treatments for Depression in Primary Care,"This review investigated whether antidepressants are more effective than placebo when used in primary care, as well as the differences in efficacy and acceptability between types of antidepressants."
  March 2015 ,Seminars in Respiratory and Critical Care Medicine,Optimizing Antimicrobial Therapy of Sepsis and Septic Shock,Explore the pathophysiology of sepsis in an attempt to produce a better understanding of antimicrobial therapy response in septic shock.
  March 2015 ,BMC Endocrine Disorders,Insulin Secretion in Latent Autoimmune Diabetes (LADA),Do patients with latent autoimmune diabetes have more endogenous insulin secretion than those with other types of diabetes?
  March 2015 ,International Ophthalmology Clinics,Uveal Melanoma: Evidence for Efficacy of Therapy,How efficacious are these various therapeutic modalities for uveal melanoma? This review evaluates current evidence.
  March 2015 ,Rheumatology,Psoriatic Arthritis: Current Therapy and Future Approaches,This article reviews the current and future treatment options for psoriatic arthritis.
  March 2015 ,Journal of Cardiovascular Electrophysiology,Catheter Ablation for VT in Patients With an ICD (CALYPSO),Is early use of catheter ablation for ventricular tachycardia superior to antiarrhythmic medications?
  March 2015 ,U.S. Pharmacist,Dual Parkinson's Disease and a Mental Health Disorder,Which antiparkinsonian agents are associated with psychosis?
  March 2015 ,Pain Management Nursing,The Pain Experience of Inpatients in a Teaching Hospital,How much do adult in-patients see pain as interfering with daily activities?
  March 2015 ,European Heart Journal,The Year in Cardiology 2014: Prevention,Recap the highlights from preventive cardiology efforts for 2014.
  March 2015 ,Future Neurology,Human-Derived Natural Antibodies as Potential Therapeutics,"This article explores the nature of self-antigens and the development of human natural antibodies as therapeutics for disease, focusing on the IgM class active in neurological disorders."
  March 2015 ,Journal of the American Geriatrics Society,Unmet Oral Health Needs of Homebound Elderly Adults,"This study reveals the poor oral health status of the homebound elderly population, highlighting the need for partnerships with the dental community to develop home-based programs for older adults."
  March 2015 ,International Journal of Clinical Practice,Overactive Bladder and the Metabolic Syndrome in Women,"Could reducing insulin resistance, obesity, and oxidative stress prevent the onset of overactive bladder? This review examined a possible association between metabolic syndrome and OAB in women."
  March 2015 ,Preventing Chronic Disease,An Analysis of Facebook Groups Related to Hypertension,People are increasingly turning to the web to for health and medical information. How are hypertension support groups being utilized on social media such as Facebook?
  March 2015 ,Annals of Surgery,Barium Impaction Therapy for Colonic Diverticular Bleeding,Is barium therapy effective in preventing recurrence of diverticular bleeding?
  March 2015 ,Medicine and Science in Sports and Exercise,Fitness Testing in the Fibromyalgia Diagnosis,Could fitness testing play a role in diagnosing fibromyalgia? This study takes a look at which tests may help detect the condition in women.
  March 2015 ,Journal of the National Cancer Institute,Diffusion of Docetaxel in Metastatic Prostate Cancer,Find out more about the drivers of docetaxel diffusion for use in patients with metastatic prostate cancer.
  March 2015 ,Nanomedicine,Drug Delivery Using Nanocarriers for Targeting Cancer Cells,"Cancer stem cells can cause drug resistance, cancer relapse and metastasis. How might nanocarriers be employed for targeting cancer stem cells for improved cancer therapy?"
  March 2015 ,Pediatric Nursing,Improved Quality of Life With Pediatric Palliative Care,Does the use of a palliative care program improve quality of life for peds patients and their families?
  March 2015 ,European Heart Journal,Predictors of BP Response in the Symplicity HTN-3 Trial,Confounding factors are revealed and may partially explain unexpected BP responses in both sham control and renal denervation groups.
  March 2015 ,International Journal for Quality in Health Care,Integrated Care Programs for Adults With Chronic Conditions,This meta-analysis summarizes current research into the effectiveness of integrated care programs for patients with chronic diseases and multimorbidity. Can they improve outcomes and reduce costs?
  March 2015 ,Current Opinion in Allergy and Clinical Immunology,Bitter Taste Receptor T2r38 in URI and Chronic Rhinosinusitis,"Airway epithelial cells express T2R receptors, but their role in airway physiology and human disease has only recently begun to be identified."
  March 2015 ,International Journal of Clinical Rheumatology,Efficacy and Tolerability of Celecoxib in Osteoarthritis,Is celecoxib an effective treatment option in osteoarthritis patients who previously failed naproxen and ibuprofen?
  March 2015 ,Pharmacogenomics,Predicting Sensitivity to Gemcitabine and Cisplatin in NCSLC,Does the presence of polymorphisms in certain genes and alterations in their miRNA expression affect in vitro chemosensitivity to cisplatin and gemcitabine?
  March 2015 ,International Journal of Clinical Practice,Treatment for Metastatic Melanoma: A New and Evolving Era,Exciting clinical developments are changing the natural history of malignant melanoma. What are the latest developments in immunotherapy and targeted therapies?
  March 2015 ,Critical Care Medicine,The Efficacy and Safety of Heparin in Patients With Sepsis,"Learn more about heparin use in patients with sepsis, septic shock, or disseminated intravascular coagulation associated with infection."
  March 2015 ,Seminars in Neurology,Clinical Approach to Posttraumatic Epilepsy,"This review examines the natural history, diagnostic considerations, and treatment options for posttraumatic epilepsy. How should clinicians approach this challenging clinical entity?"
  March 2015 ,Morbidity & Mortality Weekly Report,Adverse Events: Administration of Simulation IV Fluids,This report on the inadvertent administration of a non-sterile saline IV fluid--intended only for training--serves as a reminder that all medical products must be carefully examined before use.
  March 2015 ,Neurosurgical Focus,Pitfalls in Diagnosis and Management of Cushing's Syndrome,"Cushing's disease continues to be challenging to diagnose. This review looks at the lab tests and imaging studies commonly used, emphasizing the complexities in proper interpretation."
  March 2015 ,American Heart Journal,Cholesterol Guidelines for Multi Ethnic CVD Prevention,What's the impact of replacing NCEP/ATP III cholesterol guidelines with the new 2013 ACC/AHA guidelines for primary prevention of cardiovascular disease?
  March 2015 ,Nanomedicine,Gold Nanoparticles As Contrast Agents in x-Ray and CT,Gold nanoparticles are proving to be an excellent x-ray contrast agent due to their high x-ray attenuation and nontoxicity. What is required for their efficient use in clinical applications?
  March 2015 ,BMC Psychiatry,Statin Use and Risk of Depression,"In addition to reducing cholesterol, statins also reduce inflammation and protect against oxidative damage. Might the use of a statin reduce the risk of depression in adults?"
  March 2015 ,Pediatric Nursing,Family-Centered Transitions From Pediatric to Adult Care,Find out more about the issue of the transition from pediatric to adult care for young adults with complex chronic conditions.
  March 2015 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Estimating the Cost of Increasing Retention in HIV Care,How expensinve would it be to scale-up retention in care interventions for HIV-infected patients?
  March 2015 ,Headache,Celecoxib vs Prednisone in Medication Overuse Headache,"Abrupt cessation of the offending drug in overuse medication headache can cause severe rebound headaches and other symptoms. Is celecoxib, an NSAID, superior to prednisone for symptom reduction?"
  March 2015 ,Plastic and Reconstructive Surgery,Vaginal Labiaplasty,"In this article, a simple classification for labial protrusion is discussed along with current practices and techniques for labiaplasty."
  March 2015 ,HIV Medicine,HIV and Aging: Insights From the APHOD,How does older age affect typical HIV treatment-related outcomes?
  March 2015 ,Alimentary Pharmacology & Therapeutics,Cost-effectiveness of Ledipasvir/sofosbuvir Regimens for HCV,How do the short- and long-term health economic outcomes of the antiviral regimen of ledipasvir and sofosbuvir compare to other therapies for chronic HCV genotype 1 infection?
  March 2015 ,Diabetes,Intranasal Insulin Enhanced Functional Connectivity in T2D,Does intranasal insulin improve cognitive performance in patients with diabetes?
  March 2015 ,BMC Dermatology,Photoallergic Reaction in a Patient Receiving Vandetanib,A 51-year-old woman developed a cutaneous eruption on sun-exposed skin while on a clinical trial with the tyrosine-kinase inhibitor vandetanib. Was the drug the culprit?
  March 2015 ,Endocrine Practice,Fear of Needles in Children with T1DM on Insulin Therapy,Does needle phobia negatively affect HbA1c levels in kids with type 1 diabetes?
  April 2015 ,Future Cardiology,Use and Impact of Cardiac Medication During Pregnancy,"Learn more about the management of cardiac disease in pregnancy, as well as the known safety of cardiac medications for the mother and/or fetus."
  April 2015 ,Nephrology Dialysis Transplantation,Dialysis Modality Choice in Diabetic Patients With ESRD,Is one particular dialysis modality considered to be the most effective to treat patients with diabetes and ESRD?
  April 2015 ,The Pediatric Infectious Disease Journal,Prospective Surveillance of Antibiotic Use in the NICU,How can we improve antibiotic stewardship in the NICU?
  April 2015 ,Cardiovascular Diabetology,Adiponectin and FFAs: Association With Visceral Fat and IR,Can adiponectin identify patients at high risk for T2D and CAD?
  April 2015 ,Skin Therapy Letter,Interleukin-23 in Pathogenesis and Treatment of Psoriasis,What role does interleukin-23 play in psoriasis pathogenesis? This brief report highlights therapies targeting IL-23 that are currently in clinical trials.
  April 2015 ,Cancer Control: Journal of the Moffitt Cancer Center,Hematopoietic Stem Cells in Multiple Myeloma and NHL,Learn how the availability of novel mobilizing agents has affected the practices of oncologists and transplant specialists.
  April 2015 ,Endocrine Practice,Opioid Endocrinopathy,"Are opioids adverse effects more of a ""pain"" than you realized? Learn how opioids may be associated with hypogonadism, adrenal insufficiency, and other endocrine disorders."
  April 2015 ,Annals of Oncology,Colorectal Cancer in Older Patients: SLOG Consensus,Brush up with guideline updates for colorectal cancer treatment in the elderly.
  April 2015 ,Journal of the American College of Cardiology,Vagus Nerve Stimulation Suppresses Atrial Fibrillation,"Will autonomic neuromodulation emerge as an alternative nonpharmacological, nonablative modality to treat paroxysmal AF?"
  April 2015 ,Journal of Perinatology : Official Journal of the California Perinatal Association,Intrapartum Cesarean Delivery in Nulliparas,What factors place a women at higher risk for cesarean delivery when delivering her first child?
  April 2015 ,American Journal of Epidemiology,"Fitness, Fatness, and Depressive Symptoms",This study suggests that low cardiorespiratory fitness is more strongly associated with depression risk than obesity.
  April 2015 ,BMC Psychiatry,"Factors, Medications Associated With Depression Risk in MS","Depression is a common co-morbidity for people with multiple sclerosis, and challenging to treat pharmacologically in this group. Are there modifiable lifestyle factors that could ameliorate the risk?"
  April 2015 ,Pediatric Nursing,Intervention for Pain Assessment in Preverbal Children,What's the best way to guage pain in kids who can't talk?
  April 2015 ,Human Reproduction,Clinical Outcomes Following Cryopreservation of Blastocysts,Does vitrification of blastocysts achieve a higher clinical pregnancy rate and live delivery rate with comparable perinatal outcomes to those following conventional slow freezing methods?
  April 2015 ,Current Opinion in Rheumatology,New Treatment Paradigms in Psoriatic Arthritis,What new treatments have been approved by the FDA for use in psoriatic arthritis?
  April 2015 ,Future Oncology,Metastatic Castration-resistant Prostate Cancer,Learn more about molecular mechanisms underlying castration resistance along with insights into identifying the best sequence of new drugs.
  April 2015 ,BMC Family Practice,Factors Associated With Grade 1 Hypertension,"This study explored demographic and modifiable lifestyle factors such as diet, smoking, and alcohol use to determine their association with grade 1 hypertension."
  April 2015 ,Alcohol and Alcoholism,Motivational Interviewing to Reduce Alcohol Use in Youth,"Binge drinking is a serious problem among young people, often landing them in the emergency department. Could this time in the ED offer a window of opportunity for brief interventional counseling?"
  March 2015 ,Liver International,Development of a Vaccination Against Hepatitis E Virus,Who could most benefit from a vaccine to protect against hepatitis E?
  March 2015 ,Alimentary Pharmacology & Therapeutics,Patient-reported Outcomes in Chronic Hepatitis C,"As treatment regimens for HCV change over time, how carefully and often do patients self-report on outcome, and how can it ultimately assist clinicians to better understand the disease?"
  April 2015 ,Journal of Medical Case Reports,Extended Varenicline in a Severely Cardiopathic Smoker,"Varenicline has been associated with an increased risk of cardiovascular adverse events in high-risk patients, but this case demonstrates that it can be safely used long-term with careful monitoring."
  April 2015 ,Journal of the American College of Cardiology,Short-vs Long-Term DAPT After Drug-Eluting Stent Implantation,Compare clinical outcomes between short- and long-term DAPT post-drug-eluting stent placement.
  April 2015 ,Breast Cancer Research,Immune Cell Profile Changes and Prognosis of Breast Cancer,Find out more on how response to neoadjuvant chemotherapy helps determine breast cancer prognosis.
  April 2015 ,Clinical Lipidology,Twenty-five Years of Statins: Where Do We Go From Here?,"After more than 25 years in clinical use, statins have transformed the field of lipid management and cardiovascular risk reduction. What now?"
  April 2015 ,Southern Medical Journal,More Rules for Improving Pharmacotherapy in Older Adults,"Do you know the ""seven deadly sins of prescribing""? The second part of this two-part article review provides some additional simple, objective rules for improving pharmacotherapy in older adults."
  April 2015 ,Journal of Glaucoma,"Association Between Glaucoma, Glaucoma Therapies, and ED","Is there a link between glaucoma, beta-blocker therapy, and erectile dysfunction? This new study investigates the possible connection."
  April 2015 ,Critical Care,Preload Dependence Indices During Septic Shock,Can passive leg raising help to identify those patients who need intravascular volume expansion?
  April 2015 ,Current Opinion in Nephrology and Hypertension,Cardiorenal Syndrome in Chronic Kidney Disease,What does the latest research tell us about the mechanisms that could lead to the development of cardiorenal syndrome in patients with CKD?
  April 2015 ,The Journal of Invasive Cardiology,Effectiveness of Percutaneous VADs for High-Risk PCI,Find out more about aoutcomes for high-risk PCI and cardiogenic shock patients.
  April 2015 ,Wounds,Clostridial Collagenase and Negative Pressure Wound Therapy,Find out new ways to promote faster healing for chronic pressure ulcers.
  April 2015 ,Pediatric Pharmacotherapy,Anticoagulation With Bivalirudin in Infants and Children,Is bivalirudin a safe altenative to heparin for anticoagulation in infants and children?
  April 2015 ,Future Oncology,Does Patient Education Work in Breast Cancer?,Find out how health counseling affects breast cancer patient adherence.
  April 2015 ,Clinical Endocrinology,Lower Aldosterone-Renin Ratio Is a Risk Factor for Death,New research explores the association between the plasma aldosterone-renin ratio and mortality.
  April 2015 ,European Heart Journal,Mendelian Randomization of Blood Lipids for CHD,Find greater clarity in the causal role of HDL cholesterol and triglycerides in coronary heart disease.
  April 2015 ,Journal of the American College of Cardiology,Systolic Hypertension and Risk for Cardiovascular Mortality,Do isolated episodes of high systollic blood pressure impact cardiovascular events -- when they occur in relatively young patients?
  April 2015 ,Personalized Medicine,Pharmacogenetics and Analgesia of Antidepressants in Pain,Are antidepressants getting us one step closer to individualized pain management?
  April 2015 ,Pediatric Critical Care Medicine,Opioid and Benzodiazepine Withdrawal in Pediatric Patients,What are the most salient risk factors associated with iatrogenic withdrawal syndrome in critically ill pediatric patients?
  April 2015 ,Diabetes Care,Efficacy and Safety of Canagliflozin With Insulin for T2DM,Does the addition of this SGLT-2 inhibitor to insulin therapy improve A1c and decrease body weight?
  April 2015 ,Journal for Nurse Practitioners,Statins: Update on Clinical Issues and Adverse Effects,"With increased prescribing, evidence has emerged linking statin use with additional adverse effects. Which ones are valid?"
  April 2015 ,Future Oncology,Exceptional Responders: Science Behind Miracle Cancer Cures,Does studying exceptional responders help us foretell the future?
  April 2015 ,Annals of Surgery,Recommendations for Laparoscopic Liver Resection,Read about the status of laparoscopic liver surgery and recommendations to aid its future development.
  April 2015 ,Eye,Neuropathic Ocular Pain as a Feature of Dry Eye,"Gain a better understanding of neuropathic ocular pain associated with dry eye, and how these findings could have implications for the diagnosis and treatment of dry eye symptoms."
  April 2015 ,Current Opinion in Gastroenterology,Diet and Irritable Bowel Syndrome,Do certain foods exacerbate symptoms in IBS patients?
  April 2015 ,International Ophthalmology Clinics,Uveal Melanoma: Evidence for Adjuvant Therapy,This review provides a summary of the evidence for the use of adjuvant therapy in treatment of uveal melanoma.
  April 2015 ,Clinical Gastroenterology and Hepatology,Microscopic Colitis -- Clinical and Pathologic Perspectives,"How common is microscopic colitis, how does it develop, how does it differ histologically from other forms of colitis?"
  April 2015 ,Journal of the American College of Cardiology,Revascularization in P-PCI for STEMI and Multivessel Disease,Find out more about optimal management of patients found to have multivessel disease while undergoing primary PCI for ST-segment elevation myocardial infarction.
  April 2015 ,American Journal of Epidemiology,Duration of Nicotine Replacement Use and Smoking Cessation,How long should smokers continue nicotine replacement therapy for the highest likelihood of successfully quitting?
  April 2015 ,Breast Cancer Research,BRCA1/2 Defects and DNA Damage Repair in Breast Cancer,"Learn more about the frequency of BRCA1/2 defects among different breast cancer subtypes, and the ability of the HRD scores to identify breast tumors with defects."
  April 2015 ,American Heart Journal,Anticoagulant Therapy and Outcomes in Prior or Acute HF and ACS,Learn more about the relationship between prior HF or acute HF complicating an index ACS event and subsequent clinical outcomes.
  April 2015 ,Human Reproduction,Depression and Stress in Women With Recurrent Pregnancy Loss,"How prevalent is depression and stress in women who have experienced recurrent pregnancy loss, and how can clinicians counsel and help this group of vulnerable patients?"
  April 2015 ,BMC Infectious Diseases,Advancing Research and Practice in HIV And Rehabilitation,"The role for rehabilitation in the context of HIV, aging and comorbidities is emerging."
  April 2015 ,European Heart Journal,IV Iron Therapy in Patients With Symptomatic Heart Failure,"Find out what symptoms of heart failure can be ""ironed-out""."
  April 2015 ,Rheumatology,Biologic Treatment in Sjogren's Syndrome,How effective are biologic agents in the treatment of Sjogren's syndrome?
  April 2015 ,Urologic Nursing,Behavioral Urotherapy for Bowel and Bladder Dysfunction,What's the right dose of urotherapy for bowel and bladder dysfunction?
  April 2015 ,Future Oncology,Repurposing Drugs in Your Medicine Cabinet,Learn about situations where medicine-cabinet-mining and off-label drug use may be the right choice.
  April 2015 ,Annals of Cardiothoracic Surgery,Minimally Invasive AVR vs AVR Through Full Sternotomy,Does the mini-aortic valve replacement live up to the standard of the full sternotomy AVR?
  April 2015 ,Cardiovascular Diabetology,Cardio-Ankle Vascular Index in Diabetes or MetS,Can this index predict cardiovascular target organ damage in patients with diabetes?
  April 2015 ,Europace,RFA vs Antiarrhythmic Drug Therapy as First Line AF Treatment,Has radiofrequency catheter ablation become more effective than medical therapy as first-line treatment of paroxysmal atrial fibrillation?
  April 2015 ,Current Opinion in Ophthalmology,What to Add After Prostaglandin Analogs for Glaucoma,"In this review, the IOP-lowering efficacy of agents for use in combination with prostaglandin analogs for glaucoma is investigated."
  April 2015 ,International Journal of Clinical Practice,Liraglutide and Sitagliptin in Type 2 Diabetes,Does liraglutide offer greater glycemic contol and weight reduction than sitagliptin in clinical practice?
  April 2015 ,American Journal of Critical Care,HRV as a Predictor of Cardiac Dysrhythmias During Weaning,Arrhythmias can induce myocardial ischemia and lead to unsuccessful weaning. Can they be cut off at the pass?
  April 2015 ,International Journal of Clinical Practice,Patient-Reported Outcome Measures in Hypogonadism,Loss of sex drive and/or energy are symptoms frequently reported by men with hypogonadism. This study assessed the validity of two new patient-reported outcome measures for these patients.
  April 2015 ,Journal of Viral Hepatitis,Emergence of Resistant Variants in HCV Genotype 1,What's the relationship between pre-existing drug-resistant variants and clinical outcome of the combination treatment with daclatasvir and asunaprevir for chronic hepatitis C virus infection?
  April 2015 ,Future Oncology,Personalized Treatment of Early-Stage Non-Small Cell Lung Cancer,Learn more about phase II and III studies examining the role of EGFR inhibitors as adjuvant therapy in resected patients or as part of multimodality treatment for stage III NSCLC.
  April 2015 ,BMC Psychiatry,Quetiapine Extended Release in Patients With Schizophrenia,Is quetiapine XR an effective and well tolerated alternative for schizophrenic patients with previous suboptimal response to another antipsychotic?
  April 2015 ,Current Opinion in Pulmonary Medicine,Allergic Fungal Airway Disease: Pathophysiology and Diagnosis,"Which biomarkers are useful in helping to guide diagnosis, prognosis and treatment of allergic fungal airway disease?"
  April 2015 ,Critical Care,Original Sins of Trials With IV Immunoglobulins in Sepsis,"Learn more about potential confounding factors, concerning both the patient and the IVIG preparations, which could greatly affect sepsis outcomes."
  April 2015 ,Pediatric Pharmacotherapy,New Drugs for Children in the FDA Pipeline,"These new drugs, suitable for pediatric patients, may play a significant role in the management of diseases."
  April 2015 ,Future Oncology,Circulating Tumor DNA: New Horizons for Cancer Treatment,Learn more about a potential great leap forward in cancer care.
  April 2015 ,The American Journal of Gastroenterology,Trends and Racial/Ethnic Disparities in Gluten-Sensitivity,"Does celiac disease present and develop differently among racial and ethnic groups in the US and, if so, who is most susceptible?"
  April 2015 ,BMC Infectious Diseases,Achieving Sustained Virologic Response in Hepatitis C,"This study examines the clinical, economic and quality of life benefits associated with achieving sustained virological response in hepatitis C."
  April 2015 ,Personalized Medicine,PARP Inhibitors: Journey From Hypothesis to Approval,Will PARP inhibitors provide new options for ovarian and BRCA positive cancers? Learn the ins and outs here.
  April 2015 ,Seminars in Respiratory and Critical Care Medicine,Treatment of Methicillin-Resistant Staphylococcus aureus,Is there a drug that's superior to vancomycin in the treatment of MRSA infections?
  April 2015 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,The Decision to Hospitalize ED Patients With an SSTI,Which ED patients with SSTI are more likely to be hospitalized? A new study looks at the factors associated with the hospital admission of these patients.
  April 2015 ,American Journal of Cardiovascular Drugs,Novel Therapeutic Targets in the Management of Atrial Fibrillation,Get results from experimental and clinical research investigating targets for atrial fibrillation therapies.
  April 2015 ,HIV Medicine,Reflections That Led to the Conduct of the START Trial,"This article reviews the START study--A large, long-term HIV trial that determines when ART should be initiated."
  April 2015 ,Cardiovascular Diabetology,Superoxide Dismutase: MI and Mortality in DM Types 1 and 2,Does this antioxidant enzyme protect against diabetes-related oxidative stress?
  April 2015 ,Nephrology Dialysis Transplantation,Disease Burden and Risk Profile in Patients With Moderate CKD,"Why do patients with moderate CKD under specialist care still have a high disease burden, and how can improving diagnostic accuracy help clinicians better manage these patients and improve prognosis?"
  April 2015 ,Gastroenterology,"Alkaline Phosphatase, Bilirubin Levels and Outcomes in PBC",Do alkaline phosphatase and bilirubin levels help clinicians predict disease outcome in patients with primary biliary cirrhosis?
  April 2015 ,Alimentary Pharmacology & Therapeutics,Cytomegalovirus and Inflammatory Bowel Disease,"How common is cytomegalovirus in patients with IBD, how does it develop, and how is it best treated?"
  May 2015 ,Journal of Cardiovascular Electrophysiology,Silent Cerebral Events/Lesions Related to AF Ablation,What sort of embollic fingerprints are left after AF ablation?
  April 2015 ,Pediatric Nursing,Caring for Children With Hypoplastic Left Heart Syndrome,"Do parents of kids with hypoplastic left heart syndrome tend to be hyper-vigilant? If so, what's the impact?"
  April 2015 ,BMC Psychiatry,Escitalopram in the Prevention of PTSD,SSRIs are effective first-line pharmacotherapy for acute and chronic PTSD. Might they also be useful for PTSD prevention?
  April 2015 ,BMC Family Practice,Influenza Vaccination of Physicians and Their Patients,Are physicians who are themselves vaccinated against influenza more likely to recommend influenza vaccine to their elderly patients?
  April 2015 ,Future Oncology,Metastasis-related miRNAs: Way to Differentiate High Risk?,Get a grip on the many facets of miRNAs and explore their future potential in cancer treatment.
  April 2015 ,Journal of Pediatric Health Care,Treating Bronchiolitis in a High-Risk Pediatric Population,These clinical practice guideline for bronchiolitis could improve patient outcomes in high-risk children.
  April 2015 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Risk Factors and Mortality Associated With Resistance to ART,What factors are associated with the development of HIV drug resistance?
  April 2015 ,BMC Infectious Diseases,M. tuberculosis Bacteremia Among Patients With HIV and TB,What patient characteristics are predictors of M. tuberculosis bacteremia among HIV-infected tuberculosis suspects?
  April 2015 ,Eye,Residual Edema With Ranibizumab 0.5 mg and 2.0 mg for DME,How effective is a higher dose of ranibizumab in treating persistent DME? The REEF study investigates.
  April 2015 ,BMC Ophthalmology,Ranibizumab for Macular Edema Secondary to RVO,A new study compares the efficacy of different doses of ranibizumab for macular edema secondary to RVO -- and whether the addition of non-anti-VEGF treatment provides any additional benefits.
  April 2015 ,U.S. Pharmacist,Cardiac Fibrosis: New Treatments in Cardiovascular Medicine,Can therapy directed at cardiac fibrosis halt the progression of heart failure?
  April 2015 ,Future Neurology,Are Antibody Therapeutics Feasible for CNS Indications?,"Biologics have become an increasingly significant component of the therapeutic landscape, but delivery across the blood-brain barrier has proven challenging."
  April 2015 ,Future Oncology,Systems Oncology: Toward the Clinical Application of Cancer Systems Biology,Learn how systems oncology will revolutionize the consulting rooms of oncologists worldwide.
  April 2015 ,Current Opinion in Psychiatry,An Update on Pharmacotherapy for Autism Spectrum Disorder,"Psychotropic medications are frequently prescribed to alleviate behavioral symptoms in autism, but their efficacy is limited. What's available today and what promising approaches are under study?"
  April 2015 ,Seminars in Neurology,Diagnosis and Management of Acute Concussion,"This primer outlines what you need to know regarding accurate diagnosis and appropriate management of acute concussion, highlighting head injury sustained by athletes and military personnel."
  April 2015 ,Current Opinion in Neurology,Genetic Screening and Diagnosis in Epilepsy?,What genetic screening tools are currently available for epilepsy? This review looks at recent findings that may impact both screening and treatment.
  April 2015 ,Nutrition and Metabolism,How Do High Glycemic Load Diets Influence CHD?,Do low-fat diets really protect against cardiovascular disease?
  April 2015 ,Interventional Cardiology,Adjudicating Coronary Revascularization: Appropriate Use,Learn about problems related to the development of appropriateness criteria and modifications to guide future iterations.
  April 2015 ,Journal of Medical Case Reports,Remission in Metastatic Breast Cancer Using Pegylated Irinotecan,A novel form of the topoisomerase I inhibitor irinotecan gave impressive results in this patient with advanced metastatic breast cancer who had shown limited response to conventional treatment.
  April 2015 ,Breast Cancer Research,Coffee and Tea Consumption and Breast Cancer in EPIC Study,Is higher caffeinated coffee intake associated with lower risk of postmenopausal breast cancer?
  May 2015 ,Diabetes Care,Diabetes Remission After Bariatric Surgery in T2D,Does Roux-en-Y gastric bypass surgery work better than laparoscopic gastric banding in reversing insulin-dependent T2D?
  May 2015 ,Clinical Endocrinology,How Does Obesity Affect Fertility in Men?,Does testosterone therapy improve fertility in obese men?
  May 2015 ,BMC Anesthesiology,Dexmedetomidine Versus Remifentanil After Spinal Surgery,Does remifentanil or dexmedetomidine offer better postoperative pain control when used as an adjuvant in propofol-based anesthesia during spinal surgery?
  May 2015 ,International Journal of Clinical Rheumatology,Can We Treat to Target in Osteoporosis?,Will a treat to target strategy improve osteoporosis management?
  May 2015 ,HIV Medicine,Community Perspective on the START Trial,When should ART be initiated? The START study is expected to be completed in 2016 and should give us that answer.
  May 2015 ,Future Oncology,HR+/HER2- Advanced Breast Cancer Pretreated With Non-Steroid AIs,Compare results of trials on endocrine or targeted treatment in HR+/HER2- mBC patients who progressed after a prior NSAI therapy.
  May 2015 ,Cardiovascular Diabetology,"Association of Diastolic Dysfunction With IR, MetS and T2DM",What are underlying mechanisms of diabetic cardiomyopathy? This research aims to find out.
  May 2015 ,Skin Therapy Letter,Treatment of Plaque Psoriasis With Interleukin-17 Inhibitors,This review examines the role of interleukin-17 in the pathogenesis of plaque psoriasis and the potential implications of its inhibition. What IL-17 inhibitors are currently undergoing trials?
  May 2015 ,Diabetes,Adipose Tissue Biology: Association With IR in Children,New research in children finds that obesity causes adipose tissue dysfunction. Does this contribute to insulin resistance?
  May 2015 ,Future Virology,Clinical Translation of Biomedical HIV Prevention Strategies,What challenges do we face when implementing HIV prevention strategies into clinical policy and practice?
  May 2015 ,The Pediatric Infectious Disease Journal,Review of Tenofovir Use in HIV-Infected Children,TDF is now approved for use in HIV-infected children 2 years of age and older; but how safe is it for this patient population?
  May 2015 ,AIDS,Potential Epidemiological Impact of Pre-Exposure Prophylaxis,Could an HIV pre-exposure prophylaxis program make a significant epidemiological impact?
  May 2015 ,Alimentary Pharmacology & Therapeutics,Pharmacological Interventions for Eosinophilic Esophagitis,What are the various drug therapies available to clinicians for the treatment of eosinophilic esophagitis?
  May 2015 ,Endocrine Practice,Omitting Late-Night Eating and Hypoglycemia in T2D,Can patients using once-nightly basal insulin safely skip an evening meal?
  May 2015 ,Breast Cancer Research,Multigene Prognostic Tests in Breast Cancer,Find out how multigene prognostic tests provide useful complementary information in breast cancers.
  May 2015 ,Journal of the American Geriatrics Society,Course of Pain and Function in Older Adults With Back Pain,What's the long-term prognosis and clinical course of back pain in older adults?
  May 2015 ,BMC Oral Health,Periodontal Pockets and Blood Pressure in Obese Adolescents,Does periodontal disease in obese adolescents increase their risk of developing hypertension and cardiovascular disease?
  May 2015 ,Journal of the American College of Cardiology,Impact of Statins on Serial Coronary Calcification in Atheroma,Gain insight as to how statins may stabilize plaque beyond their effects on plaque regression.
  May 2015 ,BMC Neurology,Cognitive Impairment Six Months After Ischaemic Stroke,This study profiles cognitive impairment of stroke survivors at six months. What factors are associated with cognitive impairment post-stroke?
  May 2015 ,The American Journal of Gastroenterology,Sleep Disorders and Inflammatory Disease Activity,"Are patients with IBD prone to developing sleep disorders and, if so, what are the reasons?"
  May 2015 ,Critical Care Medicine,Prehospital Aspirin Use and Risk of ARDS in the Critically Ill,Learn more about the relationship between aspirin and ARDS.
  May 2015 ,Breast Cancer Research,Xenograft Models of Breast Cancer and Their Predictive Power,What's the utility of breast cancer patient-derived xenograft models for studying the clonal evolution of tumors?
  May 2015 ,Journal of the American Geriatrics Society,Update on Vaccination Guidelines for Older Adults,This review summarizes the current guidelines for vaccination of older adults and highlights the latest innovations.
  May 2015 ,International Journal of Clinical Practice,Lisdexamfetamine for Binge Eating Disorder in Adults,"Lisdexamfetamine dimesylate, or LDX, is the first drug to receive regulatory approval for treatment of binge eating disorder. What should you know before prescribing?"
  May 2015 ,Journal of Viral Hepatitis,Management of Treatment-naive Chronic HCV Genotype 1 Patients,"What are the newest and most promising therapies available for the treatment of chronic hepatitis C genotype 1, and are they proving to be cost-effective options?"
  May 2015 ,Southern Medical Journal,Therapeutic Options in Metastatic Castration-Resistant Prostate Cancer,Is PSA measurement useful in monitoring response to therapy in metastatic prostate cancer? What role does it play in informing clinical decision making?
  May 2015 ,Journal of the National Cancer Institute,Molecular Profiling in Trials for Advanced Metastatic Cancers,This commentary highlights some of the challenges confronting the clinical application of molecular tumor profiling and the various trial designs being utilized to address these challenges.
  May 2015 ,Gastroenterology,FIT and Colonoscopy in Familial Colorectal Cancer Screening,What is the usefulness and effectiveness of FIT screening as an alternative to colonoscopy in the familial risk population?
  May 2015 ,BMC Psychiatry,The Two-Year Course of Late-Life Depression,What factors might determine the course and prognosis of depression in the elderly?
  May 2015 ,Critical Care,Early Mobilization in Mechanically Ventilated ICU Patients,"Get up-to-speed on current mobilization practice, strength at ICU discharge and functional recovery in mechanically ventilated ICU patients."
  May 2015 ,Future Oncology,"Patient Pathway for Breast Cancer: Turning Points, Aspirations",Improved survival from breast cancer can be attributed to a number of advances in the patient pathway from screening to advanced disease. What's next?
  May 2015 ,Future Oncology,Targeted Therapies for NSCLCs With Aberrant EGF Receptors,Find out about current molecular targets that have therapies available and other targets for which therapies will be available in the near future.
  May 2015 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Cancer Risk and Combination Antiretroviral Therapy,How does combination ART affect the risk of cancer?
  May 2015 ,Future Oncology,FISH in Triple-negative Breast Cancer: Strategy of the Future?,How will using the FISH assay in TNBCs produce drastic changes in clinical practice?
  May 2015 ,American Journal of Clinical Pathology,Specimen Handling and Measurement of Complement Biomarkers,Does variation in sample collection and hadling affect complement biomarker levels?
  May 2015 ,BMC Infectious Diseases,Viral Infections in Patients With Acute Respiratory Illness,"This study examines the distribution, symptoms and illnes burden of 18 viruses among individuals with acute respiratory illness."
  May 2015 ,Journal of the American Board of Family Medicine,Magnesium Intake and Depression in Adults,Could low magnesium intake be a risk factor for depression?
  May 2015 ,Pediatric Critical Care Medicine,Progesterone for Neuroprotection in Pediatric TBI,Get up-to-speed on evaluating the therapeutic potential for progesterone treatment after pediatric traumatic brain injury.
  May 2015 ,Future Oncology,Toward a Better Management of Older Patients With Acute Myeloid Leukemia,"Significant progress has been made in the treatment of younger AML patients, but survival rates among older patients are poor."
  May 2015 ,Future Neurology,Management of Epilepsy During Pregnancy,"How should you counsel epileptic patients pre- and post conception? Read about the risks and benefits of available antiepileptic drugs, and which should be avoided during pregnancy, in this review."
  May 2015 ,International Journal of Clinical Practice,Treatment Guidelines for Community-Based Headache Treatment,How should common tension-type headache be approached? This brief review summarizes current options for both pharmacological and non-pharmacological management.
  May 2015 ,BMC Psychiatry,Vagus Nerve Stimulation for Resistant Mood Disorders,Many patients with major depression do not respond to currently available treatments. Is vagus nerve stimulation efficacious as an adjunctive treatment over the long-term?
  May 2015 ,Age and Ageing,Pharmacotherapy and Mortality in Atrial Fibrillation,What is the most appropriate pharmacotherapy for increased survival in elderly patients with atrial fibrillation?
  May 2015 ,Liver International,Transient Elastography for Chronic Viral Hepatitis,"Transient elastography is emerging as a promising noninvasive method for assessing liver fibrosis. How safe and effective is it, and does it have advantages over any other methods?"
  May 2015 ,Europace,Non-Vitamin K Antagonist Anticoagulants: Regimens and Adherence,Learn more about the peaks and valleys of suboptimal medication adherence as it relates to oral anticoagulation in patients with atrial fibrillation.
  May 2015 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Nutrition Interventions for People Living With HIV/AIDS,Do nutritional interventions at or before antiretroviral therapy initiation improve outcomes in HIV patients?
  May 2015 ,BMC Ophthalmology,Visual Outcomes After Bilateral Trifocal IOL Implantation,How did this new trifocal diffractive IOL implant perform in terms of visual and refractive outcomes?
  May 2015 ,BMC Surgery,Successful Limb Salvage Surgery in Diabetic Foot Patients,This study evaluates factors to predict the success of limb salvage surgery in diabetic foot patients and can guide clinicians in determining an appropriate amputation level for each patient.
  May 2015 ,Urologic Nursing,Advances in Female Urology,Learn more about lower urinary tract dysfunction and pelvic disorders in this comprehensive review.
  May 2015 ,Rheumatology,Indications for IVIG in Rheumatic Diseases,Which rheumatic conditions may benefit from IVIG?
  May 2015 ,Malaria Journal,Protection of Malian Children From Clinical Malaria,Recognition of multiple antigens may be crucial for protection from clinical malaria.
  May 2015 ,BMC Musculoskeletal Disorders,Physical Activity and Health-Related QoL in Low Back Pain,What are the associations between physical activity and health-related quality of life in patients suffering from chronic low back pain? This study explores the connections.
  May 2015 ,American Journal of Public Health,Ebola Crisis of 2014: Are Current Strategies Enough?,The authors of this brief article suggest three policy changes to address the long-term challenges of ebola virus disease and encourage the development of vaccines and treatments.
  May 2015 ,Menopause,Early Versus Late Intervention Trial With Estradiol,What does the baseline data from the Early versus Late Intervention Trial with Estradiol (ELITE) tell us about HT timing and its relation to atherosclerosis progression and coronary artery disease?
  May 2015 ,Current Opinion in Ophthalmology,Managing DME in the Anti-VEGF and Corticosteroid Era,Find out more about the important role anti-VEGF agents and corticosteroids have played in the management of diabetic macular edema -- and what challenges remain.
  May 2015 ,Laboratory Investigation,Mapping Spatial Heterogeneity in the Tumor Microenvironment,"This review sheds light on recent developments that analyze the tumor microenvironment using techniques such as molecular profiling, image processing and spatial statistics."
  May 2015 ,Translational Andrology and Urology,New Frontiers in Urethral Reconstruction,"This review explores the most recent advances in urethral reconstruction, with a special focus on injectable medications and alternative grafts."
  May 2015 ,Current Opinion in Nephrology and Hypertension,Blood Pressure Variability Among Chronic Dialysis Patients,Is there an established connection between blood pressure variability and adverse outcomes in chronic hemodialysis patients?
  May 2015 ,Medicine and Science in Sports and Exercise,Physical Activity and Skills Intervention,How effective was this school-based intervention in promoting physical activity and improving fundamental movement skills in children?
  May 2015 ,Annals of Family Medicine,Chronic Disease Health Coaching by Medical Assistants,Primary care practices are struggling to provide self-management support to growing numbers of patients with chronic conditions. Can health coaching by medical assistants fill in the gaps?
  May 2015 ,Medicine and Science in Sports and Exercise,Concurrent Exercise on a Gravity-Independent Device,"In this study, the authors examine the musculoskeletal and cardiovascular effects of a high-intensity concurrent exercise training protocol."
  May 2015 ,Journal of Viral Hepatitis,Cost-effectiveness of Sofosbuvir in the Treatment of HCV,"What does the latest research tell us about the cost-effectiveness of the antiviral, sofosbuvir, in the treatment of hepatitis C?"
  May 2015 ,Gastroenterology,Comparative Effectiveness of Therapies in Crohn's Disease,"Which immunosuppressants and biologics are most effective in the treatment of Crohn's disease, and are any successful at inducing and maintaining remission?"
  May 2015 ,International Journal of Clinical Practice,"Analgesic Safety - Myths, Mysteries and Misconceptions","Ibuprofen and paracetamol (acetaminophen) are commonly recommended for treatment of tension-type headache, but many worry about adverse effects. How do their efficacy--and safety profile--compare?"
  May 2015 ,American Journal of Critical Care,Transitions: Critical Care Outreach in End-of-Life Decisions,Escalation of levels of care is often not questioned until patients become critically or acutely unwell.
  May 2015 ,The Journal of Invasive Cardiology,Comparison of Fluoro and Cine Coronary Angiography,This is the first study to compare coronary angiography radiation doses and image quality between LFH and conventional cine mode techniques.
  May 2015 ,Critical Care,Aspirin Therapy in Patients With ARDS and Reduced ICU Mortality,Does an aspirin a day keep ICU patients alive?
  May 2015 ,American Journal of Cardiovascular Drugs,Management of Pump Thrombosis in Patients With LVADs,"Learn what's new in the field of mechanical circulatory support regarding diagnosis, management, and prevention of LVAD pump thrombosis."
  May 2015 ,Journal of the American Board of Family Medicine,Diagnosis and Management of Acute Coronary Syndrome,This article presents the essentials of acute coronary syndrome diagnosis and management for primary care physicians caring for patients presenting in the office as well as emergency settings.
  May 2015 ,Diabetes Care,Insulin Pump Risks and Benefits: EASD/ADA Joint Statement,Could more be done to reduce adverse events associated with insulin pump use?
  May 2015 ,BMC Musculoskeletal Disorders,Psychological Predictors of Recovery From Low Back Pain,Certain psychological factors may impact the recovery of patients receiving therapy for low back pain. What are they?
  May 2015 ,BMC Anesthesiology,Prophylactic Ondansetron in Caesarean Section,Is prophylactic ondansetron effective in reducing the incidence of pruritus and post-operative nausea in cesarean section patients?
  May 2015 ,Alimentary Pharmacology & Therapeutics,Safety of Drugs in Male IBD Patients Wishing to Conceive,"This new article underscores the importance of counseling patients with IBD desiring to have children, given that some of the drug therapies used to treat the disease could cause infertility."
  May 2015 ,Annals of Oncology,Different Chemotherapy in Older Breast Cancer Patients?,"Should older women receive special treatment, when it comes to adjuvant chemo for breast cancer?"
  May 2015 ,Current Opinion in Gastroenterology,Nonalcoholic Fatty Liver Disease: New Treatments,"What new therapies are on the market for NAFLD, and how well do they work in conjunction with lifestyle counseling to treat patients with the disease?"
  May 2015 ,Breast Cancer Research,Dysregulation of MicroRNAs in Breast Cancer and Prognosis,"Find out more about the capability of miRNAs to act as diagnostic, predictive, or prognostic biomarkers."
  May 2015 ,BMC Oral Health,Orthodontic Treatment With Fixed Appliances and Enamel Color,Does orthodontic treatment with fixed appliances alter the original color of tooth enamel?
  May 2015 ,Journal of Viral Hepatitis,Hepatitis B Reactivation During Cancer Chemotherapy,Hepatitis B virus reactivation can be a serious complication of cancer chemotherapy. How can clinicians best screen these patients and manage those who are most at risk?
  May 2015 ,The American Journal of Gastroenterology,Fundoplication vs PPIs for Treatment of GERD,What does the latest research tell us about the relative effectiveness of transoral incisionless fundoplication vs PPIs for the treatment of GERD?
  May 2015 ,Journal of Cardiovascular Electrophysiology,Undergoing 3 or More Catheter Ablation Procedures for AF,Find out what factors support the role of multiple repeat procedures for AF recurrence.
  May 2015 ,BMC Psychiatry,Screening for Cardiovascular Risk in Serious Mental Illness,Adults with serious mental illness have a high risk of cardiovascular disease. Are they being adequately screened?
  May 2015 ,Rheumatology,Rituximab in Diffuse Cutaneous Systemic Sclerosis,Could B-cell depletion be an effective intervention in patients with systemic sclerosis?
  May 2015 ,Current Opinion in Psychiatry,"rTMS, tDCS, and ECT for Resistant Psychosis of Schizophrenia",Many patients with schizophrenia fail to obtain remission from psychosis with standard treatment. This review presents the latest evidence on the effectiveness of physical stimulation alternatives.
  May 2015 ,Current Opinion in Neurology,Mechanisms of Sudden Unexplained Death in Epilepsy,What causes sudden unexplained death in epilepsy? This review provides an overview of the evidence behind the currently accepted risk factors and working hypotheses regarding SUDEP pathophysiology.
  May 2015 ,American Journal of Clinical Pathology,Visual Memory Effects on Intraoperator Study Design,How important is the impact of recall bias in pathology? This study investigates the relationship between pathologist visual case recall and the length of time between reviews of the same case.
  May 2015 ,Liver International,"Assessing Drug, Herbal, and Dietary Supplement Hepatotoxicity",What is the most effective way for clinicians to assess hepatotoxicity that could result from drug or herbal and dietary supplements?
  May 2015 ,Journal of the American College of Cardiology,Visit-to-Visit LDL Cholesterol and Cardiovascular Outcomes,Does variability in LDL-C levels affects cardiovascular outcomes?
  May 2015 ,BMC Musculoskeletal Disorders,The Design Evolution of Interbody Cages in ACDF,"How has cervical interbody implant technology changed over time, and what's in store for future designs?"
  May 2015 ,Clinical Journal of Oncology Nursing,Bladder Cancer: A Focus on Sexuality,Learn how oncology nurses are improving the sexual health of patients with bladder cancer.
  May 2015 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,"Kiosk vs In-Person Screening for Alcohol, Drug Use in the ED",Are ED patients more willing to disclose their drug and alcohol use to a computer-based screening tool?
  May 2015 ,Clinical Endocrinology,PROPIT: Study Evaluating Pitavastatin in Metabolic Syndrome,Is early statin therapy a good option for patients with metabolic syndrome?
  May 2015 ,Arthritis Research & Therapy,Proteasome Inhibitors as Therapeutics of Autoimmune Diseases,There may be a bright future for the use of proteasome inhibitors in the treatment of autoimmune diseases.
  May 2015 ,Eye,Refractive Multifocal IOL for Complicated Ocular Pathologies,A new study reports on the visual outcomes of refractive multifocal IOL implantation in cataract patients with coexisting eye diseases.
  May 2015 ,Spine,Aspirin Use and Perioperative Morbidity in Spinal Surgery,A new study examines the bleeding-related complication rates in patients who continued aspirin therapy prior to spinal surgery. How does it compare with those who preoperatively discontinued aspirin?
  May 2015 ,Annals of Oncology,Molecular Phenotypes of DCIS Predict Recurrence,Find out what types of recurrence are predicted and why it matters.
" Open Access Journal of Plastic Surgery,  May 2015 ",ePlasty,A Biodegradable Dermal Matrix In Free Flap Reconstruction,The authors report on the long-term implantation and outcomes in the first patients to receive a biodegradable temporizing matrix.
  May 2015 ,Translational Lung Cancer Research,A Critical Question for Cancer Therapy: What New Targets Exist?,Get new pieces of information that can contribute to further preclinical validation as part of the armamentarium for clinical translational research.
  May 2015 ,Breast Cancer Research,Mechanisms of Endocrine Resistance in Lobular Breast Cancer,What are the roles of miRNA and lncRNA in breast cancer progression and in the development of endocrine resistance?
  May 2015 ,BMC Endocrine Disorders,CRP Genetic Variant Is Associated With Diabetic Retinopathy,Is development of diabetic retinopathy affected by genetics of C-reactive protein?
  May 2015 ,Journal of Clinical Rheumatology,Does Starting Allopurinol Prolong Acute Treated Gout?,Should allopurinol be given to patients during and acute gout attack?
  June 2015 ,International Journal of Clinical Practice,Association Between H. pylori Infection and Risk of ESRD,Numerous studies have demonstrated that H. pylori infection is closely associated with various gastric diseases. Might it also be a risk factor for end-stage renal disease?
  June 2015 ,BMC Endocrine Disorders,Altered Platelets' Morphological Parameters in Kids With T1D,Do patients with type 1 diabetes have platelet hyperreactivity?
  June 2015 ,The Journal of Invasive Cardiology,OCT-Derived Intrastent Dimensions and FFR After Stent Implant,Post-stenting data are compared and related to MACE at follow-up in patients treated by stent implantation.
  June 2015 ,U.S. Pharmacist,The Evolving Management of Hepatitis C Virus,"It's an exciting time for hepatitis C treatment with higher success rates, fewer adverse events, and shorter durations."
  June 2015 ,Critical Care,Beta-blockers in the Critically Ill: Physiology to Evidence,"What's the latest on using beta-blockers in critically ill patients affected by sepsis, acute respiratory failure and traumatic brain injury?"
  June 2015 ,Clinical Gastroenterology and Hepatology,Fibrosis Progression in NAFLD vs NASH,Does liver fibrosis progress differently in NAFLD than in NASH? This new study investigates.
  June 2015 ,Clinical Endocrinology,Metabolic Response to Selenium Supplementation in PCOS,"Daily supplementation with selenium may provide beneficial effects in PCOS patients, a new study finds."
  June 2015 ,Journal of the National Cancer Institute,Novel Genetic Markers of Breast Cancer Survival,Find out more about genetic markers associated with breast cancer-specific survival.
  June 2015 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Sexual Relationships and PrEP Adherence and Adherence Gaps,How do different sexual relationships affect adherence to HIV pre-exposure prophylaxis?
  June 2015 ,BMC Musculoskeletal Disorders,Choice of Surgical Treatments for Lumbar Spinal Stenosis,This review examines the main points for or against various surgical treatment modalities for lumbar spinal stenosis.
  June 2015 ,Spine,Acute Cauda Equina Syndrome Caused by a Disk Lesion,What is the best course of treatment for this rare but serious condition?
  June 2015 ,Current Opinion in Rheumatology,Current Approaches to Osteoporosis Treatment,What advances in drug development have allowed clinicians to treat osteoporosis more effectively?
  June 2015 ,Annals of Oncology,Ablation Is a Valid Treatment Option for Lung Metastases,What sized lung cancer mets respond best to ablation?
  June 2015 ,Alimentary Pharmacology & Therapeutics,Alcohol and Gut Microbiota,"What does the latest research tell us about the pathogenesis of alcoholic liver disease, and how gut microbiota modulation could possibly be a target for the treatment of alcoholic liver disease?"
  June 2015 ,Cardiovascular Diabetology,Cardiovascular Events and All-cause Mortality in T2D,Can risk of death be reduced in patients with T2D? What does the research say?
  June 2015 ,BMC Anesthesiology,Intraoperative Ventilation at U.S. Academic Medical Centers,What are the current trends and practices in intraoperative ventilation management?
  May 2015 ,Journal of the American Geriatrics Society,Is It Safe to Lower BP in Older Adults With Lacunar Stroke?,This study aimed to determine safety and tolerability of lowering blood pressure in older adults with lacunar stroke. Do side effects differ in the elderly vs. younger patients?
  May 2015 ,International Journal of Clinical Practice,Incretin-Based Therapies and Cardiovascular Disease,"Incretin-based therapies offer another treatment option for patients with type 2 diabetes, and may have a beneficial effect on cardiovascular risk factors."
  May 2015 ,Journal of Cardiovascular Electrophysiology,Blood Pressure and Atrial Fibrillation: AFFIRM Analysis,Can optimal control of blood pressure mitigate the risk of recurrent atrial fibrillation?
  May 2015 ,American Heart Journal,Impact of Weight Reduction on Cardiac Structure in AF,How does the heart's structure change with weight loss?
  June 2015 ,Cardiovascular Ultrasound,Assessment of Left Ventricle Function in Aortic Stenosis,"This review focuses on the mechanisms of transition from compensatory LV hypertrophy to LV dysfunction and heart failure in aortic stenosis, and how imaging can best be used to assess these patients."
  June 2015 ,International Journal of Impotence Research,Attachment Styles and Sexual Dysfunctions,"What is the association between attachment styles and sexual function, and how does it differ between genders?"
  June 2015 ,BMC Anesthesiology,Required Propofol Dose for Anesthesia and Time to Emerge Are Affected by the Use of Antiepileptics,How do neurological disorders and their medications affect propofol dosing?
  June 2015 ,Schizophrenia Bulletin,MRI and Prediction of Outcome in First-Episode Schizophrenia,Could MRI be a useful tool for identifying neuroanatomical markers in patients with a first-episode of schizophrenia? And might these markers serve as predictors of outcome and response to treatment?
  June 2015 ,Annals of Oncology,Prevention of Chemotherapy-Induced Nausea and Vomiting,"Emerging from this research are two new antiemetic agents, netupitant/palonosetron, the first antiemetic combination agent and rolapitant, a new NK1RA."
  June 2015 ,Europace,Quality of Anticoagulation Control in Non-valvular AF,Is this a useful tool for selecting patients who would have anticoagulation control issues with vitamin K antagonists?
  June 2015 ,Journal of the American Geriatrics Society,Cholinesterase Inhibitors for Dementia and Risk of Pneumonia,Concerns have been raised regarding the potential risk of pneumonia associated with cholinesterase inhibitors in patients with dementia. Is one drug safer than another in this respect?
  June 2015 ,Menopause,Bilateral Salpingo-oophorectomy and Pelvic Organ Prolapse,Is bilateral salpingo-oophorectomy at the time of hysterectomy associated with an increased risk of pelvic organ prolapse?
  June 2015 ,BMC Psychiatry,Psychoeducation in Bipolar Patients With a Smart-Phone App,The authors propose a smartphone application to monitor symptoms and signs and empower the self-management of bipolar disorder.
  June 2015 ,Respiratory Research,Anti-inflammatory Effects of Curcumin in Acute Lung Injury,"Curcumin, extracted from turmeric, exhibits broad anti-inflammatory properties through down-regulating inflammatory cytokines. Is it effective for ALI?"
  June 2015 ,Current Opinion in Ophthalmology,Advances in Drug Delivery to the Posterior Segment,"What emerging drug delivery technologies are on the horizon for vitreoretinal diseases, and how do they perform in terms of safety and efficacy?"
  June 2015 ,Journal of Pediatric Health Care,"Eating Behaviors, Physical Activity, and Obesity in Teens","This study examines characteristics of African American adolescents in regard to eating behaviors, physical activity, and obesity."
  June 2015 ,European Heart Journal,Pulse Pressure in Heart Failure Patients With Reduced EF,Is lower pulse pressure predictive of mortality in patients with heart failure?
  June 2015 ,Pediatric Pharmacotherapy,9-Valent Human Papillomavirus Virus (HPV) Vaccine,"The new 9-valent HPV vaccine offers additional protection against strains known to produce cancer, but low vaccine uptake throughout the United States lessens the potential benefits of the vaccine."
  June 2015 ,The British Journal of Dermatology,MSLT-I Confirms Role of SNL Biopsy in Melanoma Management,The authors of the Multicenter Selective Lymphadenectomy Trial present a rebuttal to the criticism of their conclusions regarding the utility of SNL biopsy in melanoma.
  June 2015 ,BMC Urology,Controversies in the Treatment of Urothelial Carcinoma,Learn more about the therapeutic options available for invasive bladder cancer -- and which patient characteristics may influence treatment decisions for this advanced disease.
  June 2015 ,Spine,Assessing Patient-Rated Outcome in Spinal Stenosis,How do these instruments compare in terms of assessing outcomes in patients undergoing surgery for lumbar spinal stenosis?
  June 2015 ,American Journal of Public Health,Accelerated HBV Vaccination Schedule in Drug Users,Adherence to the standard vaccination schedule of the hepatitis B vaccine is a common problem among drug users. Could an accelerated schedule provide sufficient protection while improving compliance?
  June 2015 ,Prostate Cancer and Prostatic Diseases,Impact of Metformin on Clinical Outcomes in Prostate Cancer,"Metformin is traditionally a diabetes medication, but it may also provide beneficial effects in prostate cancer patients."
  June 2015 ,Alimentary Pharmacology & Therapeutics,Optimize Dosing of Anti-TNF Biologics in Ulcerative Colitis,How can clinicians properly administer anti-TNF biologics in order to most effectively treat patients with acute severe ulcerative colitis?
  June 2015 ,Translational Lung Cancer Research,Targeted Therapy for Non-Small Cell Lung Cancer,Examine the major subtypes of oncogenic drivers behind NSCLC as well as the development of targeted agents available to treat them.
  June 2015 ,Current Opinion in Pulmonary Medicine,Ventilator-associated Infection: Role for Inhaled Antibiotics,What's the rationale for inhaled antibiotic therapy?
  June 2015 ,Cardiovascular Diabetology,Association of Serum ANGPTL2 With Carotid IMT in T2D,Is this inflammatory adipokine associated with atherosclerosis in diabetes? Read the research here.
  June 2015 ,BMC Endocrine Disorders,Liraglutide and Atherothrombotic Risk in Women With PCOS,Does this GLP-1 receptor agonist reduce CV risk and promote weight loss in women with PCOS?
  June 2015 ,Journal of Medical Case Reports,Aerobic Retraining in Combined Pulmonary Fibrosis/Emphysema,"Combined pulmonary fibrosis and emphysema has recently been recognized as a syndrome, but management options have not yet been defined. Could an aerobic physical retraining program be of benefit?"
  June 2015 ,Social Cognitive and Affective Neuroscience,"Randomness, Anxiety, and Performance Monitoring",Why is the concept of randomness so unsettling--and why does a sense that there is order in the world bring comfort?
  June 2015 ,Journal of the American Geriatrics Society,Timing of Insulin Initiation in Older Patients With T2DM,"In older diabetic patients with poor glycemic control, should insulin therapy be started sooner than later? This study examines outcomes after controlling for complexities specific to older adults."
  June 2015 ,U.S. Pharmacist,Probiotics as a Treatment for Infectious Diseases,"Can the ""good"" bacteria in probiotics help treat the common cold, vulvovaginal candidiasis, or antibiotic-associated diarrhea?"
  June 2015 ,International Journal of Clinical Practice,Sitagliptin vs. Sulfonylureas in Elderly Patients With T2DM,"Sulfonylureas are commonly used to treat T2DM in elderly patients, but they are associated with an increased risk of hypoglycaemia. Is sitagliptin a better choice?"
  June 2015 ,International Ophthalmology Clinics,Intravitreal Injections and Endophthalmitis,"What do we currently know about this complication of intravitreal injections, and how is it best prevented and managed?"
  June 2015 ,BMC Psychiatry,Positive Memory Training for Depression Within Schizophrenia,Depression is highly prevalent in individuals with schizophrenia. Can a brief cognitive intervention based on a competitive memory theory of depression improve outcomes?
  June 2015 ,American Journal of Clinical Dermatology,CAM for Psoriasis: What the Dermatologist Needs to Know,"The use of complementary and alternative medicine is common among patients with psoriasis. What works, and what doesn't?"
  June 2015 ,European Heart Journal,Major Bleeding in AF Patients Treated With Apixaban or Warfarin,"Learn more about the clinical consequences of major bleeds, as well as management and treatment effects of warfarin vs. apixaban."
  June 2015 ,Arthritis Research & Therapy,"Mortality, Revascularisation and MI With Rheumatic Disease",Patients with autoimmune rheumatic diseases have increased mortality rates and decreased rates of revascularization treatment after MI. What more can be done for these high risk patients?
  June 2015 ,Diabetes Care,Web-Based Intervention to Treat Depression in Diabetes,Can internet-based interventions improve the emotional status of patients with diabetes?
  June 2015 ,Spine,The Top 100 Classic Papers in Lumbar Spine Surgery,This review identifies the most important studies in lumbar spine surgery. How they have impacted advancements in the field?
  June 2015 ,BMC Urology,Effects of Tadalafil Treatment After Radical Prostatectomy,What benefits does treatment with this PDE5 inhibitor offer for patients who underwent nerve-sparing radical prostatectomy?
  June 2015 ,HIV Medicine,Significant Drug Interactions in HIV-Infected Patients,"Drug-drug interactions are common in HIV-infected patients, and could represent major health problems. Which patients are most at risk?"
  June 2015 ,Nephrology Dialysis Transplantation,Disease Assessment in Systemic Vasculitis,"What is the most effective method of assessing disease level in systemic vasculitis, and how could biomarkers produce a more accurate description of disease and identify potential targets for therapy?"
  June 2015 ,Cardiovascular Diabetology,Decreased Uric Acid Excretion Is Risk Factor for CKD in T2D,How does decreased uric acid excretion affect patients with diabetes?
  June 2015 ,Eye,Defining Response to Anti-VEGF Therapies in Neovascular AMD,Understanding the factors that may impact the response to an anti-VEGF agent for neovascular AMD will assist clinicians in tailoring treatment strategies to optimize outcomes.
  June 2015 ,The North American Menopause Society (NAMS),Hormone Therapy and Cognition in Postmenopausal Women,Could hormone therapy improve cognition in women with moderate to severe vasomotor symptoms?
  June 2015 ,Alimentary Pharmacology & Therapeutics,MRE vs. CPRs for Noninvasive Diagnosis of Fibrosis in NAFLD,"Compared to clinical prediction rules, does magnetic resonance elastography provide a significantly higher accuracy for the diagnosis of advanced fibrosis in NAFLD patients?"
  June 2015 ,Skin Therapy Letter,Regulating Off-Label Promotion of Medications,"In this review, the authors discuss the risks and benefits of off-label drug use in dermatology, from both a clinical and a legal standpoint."
  June 2015 ,Current Opinion in Allergy and Clinical Immunology,Clinically Relevant Outcomes for New Asthma Therapies,New genetic and metabolic biomarkers for asthma could improve asthma prognostics. Find out how.
  June 2015 ,BMC Oral Health,Non-surgical Treatment of Caries in Preschool Children,"How effective are non-surgical methods, such as sealants or other topical therapies, in arresting or slowing down the progression of active dental caries in primary teeth?"
  June 2015 ,Kidney International,Alcohol Consumption and Risk of Developing CKD,"What does this new study tell us about the connection between alcohol consumption and the risk for developing CKD, and how should clinicians counsel their patients about the risks?"
  June 2015 ,Current Opinion in Neurology,Migraine Aura: New Ideas About Cause and Significance,"This review examines recent advances in the understanding of aura and its role in migraine, providing new insight into not only migraine but also fundamental mechanisms of brain physiology."
  June 2015 ,Headache,Implications of Opioid-Induced Central Immune Signaling,Central nervous system immune signaling has been implicated in the adverse effects of opioids. How does this mechanism factor into opioid tolerance and hyperalgesia?
  June 2015 ,BMC Psychiatry,Treating Depression and Anxiety in Chronic Somatic Diseases,This study assessed the safety and efficacy of short-term use of deanxit as an adjuvant to an SSRI antidepressant in patients with depression and anxiety due to chronic illness.
  June 2015 ,Rheumatology,High-Risk Pregnancy and the Rheumatologist,How risky is pregnancy in women with rheumatic diseases?
  July 2015 ,Laboratory Medicine,Heritability of IL-1A Gene Promoter Polymorphism in CAD,Find out about the connection between IL-1A-889 functional polymorphism and CAD.
  June 2015 ,Liver International,Hepatobiliary Malignancies in Wilson Disease,"Are patients with Wilson disease at risk for hepatobiliary malignancies and, if so, how do they develop and how are they diagnosed?"
  June 2015 ,Nursing Economics,Relationship Between RNs and Nursing Home Quality,Are RNs the golden key to nursing home quality?
  June 2015 ,Brain,Mendelian and Mitochondrial Disorders in Patients With Suspected MS,A number of genetic disorders share clinical and MRI characteristics with multiple sclerosis and may be overlooked in the differential diagnosis. What features might serve as red flags?
  June 2015 ,European Heart Journal,Sudden Cardiac Death in the Young: Surviving Relatives,What is a molecular autopsy and how can it help grieving families?
  June 2015 ,American Journal of Cardiovascular Drugs,Managing Comorbidities in Patients With Chronic Heart Failure,"Find out which medications used to treat diabetes, pain, arrhythmias, and depression may be associated with increased risk in patients with heart failure."
  June 2015 ,BMC Urology,QoL Outcomes After Radiotherapy or Radical Prostatectomy,"How is patient health-related quality of life impacted after these therapies for prostate cancer, and how does it compare between the treatment options?"
  June 2015 ,The British Journal of Dermatology,Predictors of SNL Positivity in Cutaneous Melanoma,"Might dermoscopic variables such as blotch, atypical pigmented network and ulceration be predictive of sentinal lymph node positivity?"
  June 2015 ,Arthritis Research & Therapy,"Cholinergic Pathways, the Immune System and Arthritis",What part do the nervous and immune systems play in the pathogenesis of rheumatoid arthritis?
  July 2015 ,BMC Ophthalmology,Comparing Intravitreal Aflibercept With Other DME Therapies,How do these therapeutic options for diabetic macular edema compare with intravitreal aflibercept injections in terms of visual acuity outcomes?
  July 2015 ,Pediatric Pharmacotherapy,Montelukast: Pediatric Asthma and Allergic Rhinitis,A number of new studies are adding to our understanding of the safety and efficacy of montelukast in children.
  July 2015 ,Neurosurgical Focus,Deep Brain Stimulation for Psychiatric Disorders,"Read about the growing body of evidence demonstrating the value of deep brain stimulation for psychiatric disorders, including major depression, PTSD, eating disorders, OCD, and addiction."
  July 2015 ,Annals of Surgery,The Use of Caffeinated Substances by Surgeons,How often do surgeons use caffeinated substances to cope with work fatigue?
  July 2015 ,BMC Musculoskeletal Disorders,Effectiveness of Intra-Articular SBCG Injections for Knee OA,Is this intervention a safe and effective option for the treatment of knee osteoarthritis?
  July 2015 ,Cardiovascular Diabetology,DRIN for Predicting Renal Outcome in T2D and Hypertension,Is this measure a useful means of predicting the onset of chronic kidney disease in hypertensive and type 2 diabetes patients?
  July 2015 ,Journal for Nurse Practitioners,NP Pioneers--Celebrating 50 Years of Role Development,Read reflections of nurse practitioner pioneers who were intimately involved with developing the NP role.
  July 2015 ,Journal of the American Geriatrics Society,Efficacy and Safety of SSRIs and SNRis in Older Adults,Antidepressant use in older adults may lead to more adverse events because of polypharmacy and age-related conditions. How safe and effective are SSRIs and SNRIs in this population?
  July 2015 ,Critical Care Medicine,Stress Disorders in Survivors of Severe Sepsis,Just how long does it take to shake off the stress of a critical illness?
  July 2015 ,Journal of Perinatology : Official Journal of the California Perinatal Association,Effects of Prone Positioning in Neonates,This study monitors the cardiovascular response to short-term prone positioning in neonates.
  July 2015 ,BMC Endocrine Disorders,Individualized Treatment Targets for T2D and Hypertension,This article examines the effectiveness of patient-tailored therapeutic approaches among those with type 2 diabetes and hypertension. Were treatment goals achieved?
  July 2015 ,The American Journal of Gastroenterology,Utility of a Biomarker Panel for Eosinophilic Esophagitis,How useful is a panel of serum biomarkers for the diagnosis and management of eosinophilic esophagitis?
  July 2015 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Racial Differences in Opiate Administration for Pain Relief,Does patient race influence the likelihood of receiving pain relief in the ED? This study explores the potential racial disparity in opiate administration.
  July 2015 ,Journal of the National Cancer Institute,Assessment of HPV Types in Cancers: Implications for Vaccines,Will current vaccines reduce most HPV-associated cancers?
  July 2015 ,The North American Menopause Society (NAMS),Laser Treatment Safe for Vulvovaginal Atrophy?,Does laser technology look promising as a future treatment for vulvovaginal atrophy?
  July 2015 ,Journal of the American College of Cardiology,Cardiopulmonary Benefits of Reducing Indoor Particles,What are the cardiopulmonary benefits of indoor air purification?
  July 2015 ,Emerging Infectious Diseases,Additional Drug Resistance of Multidrug-Resistant TB,Better TB drugs and shorter regimens are urgently needed to enable more effective treatment for multidrug-resistant TB.
  July 2015 ,Morbidity & Mortality Weekly Report,Group B Meningococcal Vaccine in Persons at Increased Risk,The FDA recently approved two group B meningococcal vaccines for use in persons aged 10-25 years. What are the latest recommendations on the use of this vaccine in high-risk populations?
  June 2015 ,BMC Urology,Reimbursement Cuts and Changes in ADT for Prostate Cancer,What was behind the decrease in inappropriate ADT use following reimbursement cuts for GnRH agonists in 2004 and 2005?
  June 2015 ,Diabetes Care,Is There a Link Between Liraglutide and Pancreatitis?,Does liraglutide therapy contribute to the incidence of acute or chronic pancreatitis among type 2 diabetics? Find out about the possible connection.
  July 2015 ,U.S. Pharmacist,Management of Adolescent Obesity,"Pharmacists play an crucial role in the fight against adolescent obesity, providing counseling on weight-management drugs and educating patients about nutrition and obesity related comorbidities."
  July 2015 ,Pediatric Critical Care Medicine,Noninvasive Support and Ventilation for Pediatric ARDS,Find out more about noninvasive positive pressure ventilation in pediatric patients with ARDS.
  July 2015 ,Headache,Migraine's Premonitory Phase: What Can We Learn From It?,"This study used functional neuroimaging to elucidate the mechanisms behind the premonitory symptoms of migraine, such as nausea, photophobia, and emotional changes."
  July 2015 ,BMC Endocrine Disorders,The Q-Score for Continuous Glucose Monitoring in Diabetes,What role could this new metric play in the care and management of diabetes?
  July 2015 ,International Ophthalmology Clinics,Inflammatory Mechanisms of Age-Related Macular Degeneration,This article provides some insight into the mechanisms of inflammation in AMD and discusses the potential therapeutic role immunotherapy may play in this disease.
  July 2015 ,International Journal of Clinical Practice,Liraglutide Subcutaneous Injection for Weight Loss,"A new injectable agent for weight loss, liraglutide, has recently been approved. How does it compare with oral weight loss drugs in terms of mechanism of action, efficacy, tolerability, and safety?"
  July 2015 ,Current Opinion in Gastroenterology,Biosimilars in Inflammatory Bowel Disease,Could biosimilars help change the future landscape of IBD treatment?
  July 2015 ,BMC Psychiatry,Prevention of Psychosis in the Symptomatic Prodromal Phase,"Many patients experience a long period with prodromal, non-psychotic symptoms before their first psychotic episode. Can these high-risk patients be identified, and psychosis prevented?"
  July 2015 ,Cardiovascular Diabetology,Normal-Weight Obesity and Subclinical Atherosclerosis Risk,A new study examines the rates of subclinical atherosclerosis in both normal-weight obese subjects and lean individuals. How do they compare?
  July 2015 ,European Heart Journal,Statin-Associated Muscle Symptoms: Impact on Statin Therapy,Statin-associated muscle symptoms are one of the principal reasons for statin non-adherence. What's the plan when patients don't tolerate statins?
  July 2015 ,International Journal of Impotence Research,Effect of Levitra on Sustenance of Erection (EROS),A flexible dose of vardenafil for ED was shown to improve erection duration and satisfaction for both patient and partner.
  July 2015 ,Spine,Risk Factors for Readmissions After Spine Surgery,What are the main reasons for unplanned hospital readmissions after instrumented spine surgery?
  July 2015 ,Arthritis Research & Therapy,Safety of Tocilizumab vs. TNF Inhibitors in RA,Should tocilizumab or tumor necrosis factor inhibitors be used for rheumatoid arthritis treatment? This study compares long-term safety.
  July 2015 ,Diabetes Care,Treatment of T1D Complicated by Problematic Hypoglycemia,This article offers an evidence-based algorithm to help guide clinicians in making treatment decisions for type 1 diabetics with problematic hypoglycemia.
  July 2015 ,Nutrition and Metabolism,Beneficial Effects of Nitrates in T2D and Its Complications,What benefits could dietary nitrates offer patients with type 2 diabetes?
  July 2015 ,American Journal of Transplantation,"Genomic Profiles, Allograft Dysfunction, and Liver Transplant","Find out more about the molecular mechanisms involved in early allograft dysfunction, along with gene expression signatures."
  July 2015 ,BMC Urology,Instillation of Intravesical Chemo During Nephroureterectomy,What does the latest research tell us about the safety of intravesical instillation of cytotoxic chemotherapy in patients undergoing nephroureterectomy?
  July 2015 ,American Heart Journal,Kexin Type 9 Inhibitor Alirocumab in High Risk Patients,Find out how patients with high cardiovascular risk and suboptimally controlled hypercholesterolemia respond to this adjunct therapy.
  July 2015 ,Alimentary Pharmacology & Therapeutics,Dietary Fiber and FODMAP-Restricted Diet in IBS,"Is there sufficient evidence to recommend dietary interventions with fiber in chronic constipation and IBS, and a FODMAP-restricted diet in IBS?"
  July 2015 ,Cardiovascular Diabetology,Baseline Diabetes as a Way to Predict CV Outcomes,A new meta-analysis of major lipid-modifying trials examines the prevalence of diabetics and incident cardiovascular events in these studies.
  July 2015 ,Current Opinion in Neurology,Novel and Emerging Treatments in Relapsing-Remitting MS,Treatment options for relapsing-remitting multiple sclerosis are evolving rapidly. This article summarizes the many novel and emerging disease-modifying treatments currently in trials.
  July 2015 ,Alimentary Pharmacology & Therapeutics,Dietary Fiber-Microbiota Interactions,What kind of impact could short- and long-term alterations in dietary fiber have on the gut microbiome?
  July 2015 ,BMC Oral Health,Aggressive Periodontitis: Antibiotics or PDT as an Adjunct?,Is photodynamic therapy as effective as antibiotics as an adjunct to nonsurgical periodontal treatment in aggressive disease?
  July 2015 ,Pediatric Pharmacotherapy,Use of Aprepitant to Prevent Nausea and Vomiting in Children,Aprepitant may be a valuable tool in the prevention of chemotherapy-induced or postoperative nausea and vomiting in children.
  July 2015 ,Rheumatology,Whole-Body MRI in Psoriatic Arthritis and Spondyloarthritis,Should whole body MRI be used to assess peripheral and axial joints in PsA and SpA?
  July 2015 ,BMC Psychiatry,Psychotic and Schizotypal Symptoms in OCD,Are psychotic and schizotypal symptoms more prevalent among non-psychotic patients with OCD than in patients with other emotional disorders?
  July 2015 ,Pediatric Nursing,Cyberbullying: A 21st Century Health Care Phenomenon,Gain insight into the phenomena of traditional bullying and cyberbullying in adolescents.
  July 2015 ,European Heart Journal,"Sleep Disordered Breathing, Mortality in Acute Heart Failure",What does the latest research tell us about the effect of sleep disordered breathing on post-discharge mortality in patients with acute heart failure?
  July 2015 ,Current Opinion in Pulmonary Medicine,Improving Outcomes From Community-acquired Pneumonia,Find out what the best practice bundles include --for patients with community-acquired pneumonia.
  July 2015 ,Liver International,Hepatopulmonary Syndrome and Portopulmonary Hypertension,"What does the latest research tell us about the pathophysiology of both hepatopulmonary syndrome and portopulmonary hypertension, and how important is an early diagnosis and clinical assessment?"
  July 2015 ,Cardiovascular Diabetology,Cardiovascular Safety of Linagliptin in Type 2 Diabetes,Data from a pooled safety analysis of linagliptin find that this therapy is an effective option for type 2 diabetes and was not associated with an increased CV risk.
  July 2015 ,Translational Lung Cancer Research,Adjuvant Chemotherapy in NSCLC: State-of-the-Art,Adjuvant chemotherapy now plays a significant role in the treatment of resected NSCLC patients and has become standard in clinical practice.
  July 2015 ,Spine,Delays to Surgery for Cervical Spinal Cord Injuries,A new study finds that many patients with cervical spinal cord injury do not undergo surgery within 24 hours of injury. What accounts for these delays?
  July 2015 ,Arthritis Research & Therapy,Lupus Nephritis Response Criteria in Lupus Activity Indices,"To advance the knowledge of how to treat lupus nephritis, well-designed clinical trials informed by prior randomized controlled trials are needed."
  July 2015 ,The British Journal of Dermatology,Smartphone Applications for Melanoma Detection,What smartphone apps are currently available to aid in the detection of melanoma by the general public and clinicians? How useful are they?
  July 2015 ,AIDS,HBV-Active HAART Regimens in an HIV-HBV Multinational Cohort,Which method of HAART is preferred to treat HIV-HBV co-infected patients?
  July 2015 ,Journal of the American Geriatrics Society,GI Antispasmodics and Anticholinergics: Risk in Older Adults,"GI antispasmodic and anticholinergic drugs continue to be prescribed for older adults, despite concerns about their safety in this population. Do they contribute to actual injury in the elderly?"
  July 2015 ,Wounds,Honey: A Biologic Wound Dressing,Find out more about the bioactivity of honey and it's uses for wound management.
  July 2015 ,Alimentary Pharmacology & Therapeutics,Comparing Therapeutic Regimens for Pediatric Chronic HCV,What is the most effective way to treat chronic hepatitis C in children?
  July 2015 ,Nephrology Dialysis Transplantation,Glomerular Filtration Rate and Coronary Artery Calcification,What is the connection between glomerular filtration rate and the risk for coronary artery calcificaition in middle-aged men without CKD?
  August 2015 ,Journal for Nurse Practitioners,Advances in Hepatitis C Treatment: At the Crossroads,Get up-to-date on new antiviral regimens for hepatitis C.
  August 2015 ,AIDS,Defining Success With HIV Pre-Exposure Prophylaxis,What makes HIV pre-exposure prophylaxis successful?
  August 2015 ,American Journal of Clinical Pathology,AML With Genetic Abnormalities Other Than Translocations,"This review focuses on the diagnosis, classification, and molecular genetic features of AML cases with common AML-associated mutations."
  August 2015 ,The American Journal of Gastroenterology,Colonoscopic Surveillance for Neoplasia in Ulcerative Colitis,"How common is colorectal cancer in patients with ulcerative colitis, and how effective is colonoscopy at detecting it in this subset of patients?"
  August 2015 ,Journal of the American College of Cardiology,Circulating Biomarkers of Myocardial Fibrosis,"Myocardial fibrosis impairs cardiac function, in addition to facilitating arrhythmias and ischemia, and thus influences the evolution and outcome of cardiac diseases."
  August 2015 ,Alimentary Pharmacology & Therapeutics,Efficacy and Safety of Daclatasvir for Chronic HCV,Are drug therapy regimens that include daclatasvir considered safe and effective in the treatment of chronic HCV?
  August 2015 ,Journal of Perinatology : Official Journal of the California Perinatal Association,Ultrasound Vs X-ray to Confirm ET Tube Position in Neonates,The standard of care is to confirm the position of an ETT in a neonate via X-ray. Can ultrasound be used instead?
  August 2015 ,Breast Cancer Research,Quantification of HER Family Receptors in Breast Cancer,Are we ready for better assays to quantify HER receptors and categorize patients for individualized treatments?
  July 2015 ,Pediatric Critical Care Medicine,Comorbidities and Assessment of Severity of Pediatric ARDS,What's the impact of disease-related characteristics on the severity of illness and on outcome in pediatric patients with ARDS?
  July 2015 ,International Journal of Clinical Practice,Reflux Esophagitis: Does the Choice of PPI Matter?,This analysis compared the long-term outcomes of commonly used proton-pump inhibitors used in the treatment of gastroesophageal reflux disease. Is one significantly more effective than the others?
  July 2015 ,BMC Psychiatry,Characterization of Autistic Phenotypes in Schizophrenia,"Until recently, autism spectrum disorders and schizophrenia were considered distinct, but there can be considerable overlap in phenotype. Could similar biological pathways be involved?"
  July 2015 ,European Heart Journal,Plaque Rupture and Intact Fibrous Cap in Patients With ACS,"What's the prognostic value of plaque rupture, compared with intact fibrous cap, in patients with ACS?"
  July 2015 ,Spine,Lumbar Fusion Rates With and Without the Use of rhBMP-2,Does this biologic product offer any additional fusion benefits in lumbar fusion surgeries? Do any benefits outweigh the risks?
  July 2015 ,Schizophrenia Bulletin,The Assessment of Schizotypy and Its Clinical Relevance,How should schizotypal traits be assessed? This review discusses the merits of both clinical and psychometric approaches.
  July 2015 ,Cardiovascular Diabetology,"Differential HDL-C Response to Metformin by Race, Ethnicity",How do HDL-C level changes in response to metformin treatment differ between ethnicities?
  July 2015 ,BMC Infectious Diseases,Hepatic Tuberculosis With HIV Co-Infection,"This systematic review is examines the existing data on the epidemiology, pathophysiology, clinical features, diagnosis, and treatment of hepatic TB."
  July 2015 ,Cancer Control: Journal of the Moffitt Cancer Center,Advances in EGFR as a Predictive Marker in Lung Adenocarcinoma,Find out how EGFR can be used to better match chemotherapy to lung cancer tumors.
  July 2015 ,The Pediatric Infectious Disease Journal,Preterm Infants Readmitted With Viral Respiratory Infections,This study examines the characteristics of preterm children who have been readmitted to the hospital due to a respiratory infection.
  July 2015 ,Gastroenterology,Accuracy of Capsule Colonoscopy to Detect Colorectal Polyps,What does the latest research tell us about the accuracy and effectiveness of capsule colonoscopy in the detection of colorectal polyps?
  July 2015 ,The Nation's Health,US Charting New Path to Combat Growing Antibiotic Resistance,"By focusing on drug development and better diagnostics, a new national action plan could help us gain the upper hand on antibiotic resistance."
  August 2015 ,Journal of Cardiovascular Electrophysiology,Symptoms Before Sudden Arrhythmic Death Syndrome,How many patients experience cardiac symptoms prior to sudden cardiac death?
  August 2015 ,Current Orthopaedic Practice,Surgical Wound Closure in Orthopaedic Surgery,This article discusses various wound closure strategies to optimize wound healing after orthopaedic surgical procedures.
  August 2015 ,BMC Anesthesiology,Dose of Dexmedetomidin After Desflurane for Tonsillectomy,What is the appropriate dose of dexmedetomidine for prevention of agitation after desflurane anesthesia for children having their tonsils removed?
  August 2015 ,Arthritis Research & Therapy,The Genetic Architecture of Hyperuricemia and Gout,How do genetics influence the development of gout in the presence of hyperuricemia?
  August 2015 ,Gastroenterology,Infliximab Dosing for Patients With IBD,"How important is infliximab dosing for patients with IBD, and how does it ultimately affect treatment outcomes?"
  August 2015 ,Journal of the American Geriatrics Society,Differences in Health at Age 100 According to Sex,"The number of individuals reaching advanced age is growing rapidly, but how healthy are they? This study used EHR's to determine differences in health status in men and women who reach 100."
  August 2015 ,Seminars in Neurology,Mitochondrial Causes of Epilepsy,"In this review, learn how to recognize and treat the various mitochondrial disorders in which seizures are an important component."
  August 2015 ,Clinical Journal of Oncology Nursing,Ibrutinib: A New Targeted Therapy for Hematologic Cancers,Nurses have an important role in educating patients about the actions and effects of new targeted therapies.
  August 2015 ,American Heart Journal,RAS Blockers and AKI in Renal Patients Having Cardiac Cath,Does holding ACE inhibitors or ARBs before coronary angiography reduce contrast-induced acute kidney injury?
  August 2015 ,Journal of the American College of Cardiology,Left Atrial Appendage Closure for Stroke Prevention in AF,How do stroke rates fare for patients with nonvalvular atrial fibrillation having left atrial appendage closure vs standard care with anticoagulants?
  August 2015 ,Alimentary Pharmacology & Therapeutics,The Patient's Journey With Chronic Hepatitis C,"How do interferon and ribavirin impact health-related quality of life during treatment for chronic hepatitis C, and are patients better off with different drug therapies?"
  August 2015 ,Translational Andrology and Urology,The PCP and the Cancer Patient: Managing Sexual Health,Primary care physicians can play an important role in addressing treatment-related sexual problems for cancer survivors.
  August 2015 ,Age and Ageing,Antidiabetic and Cardiovascular Drugs in T2DM Patients > 80,Are very elderly patients who have recently been diagnosed with diabetes being under- or over-treated?
  August 2015 ,BMC Pulmonary Medicine,Prescribing Long-Acting Inhaled Corticosteroids After SMART,Learn more about related prescription patterns after the SMART trial in Germany.
  August 2015 ,Journal of Medical Case Reports,Fish Oil for Breast Cancer Patients Undergoing Chemotherapy,"Can fish oil supplementation improve the antioxidant status of women undergoing chemotherapy for breast cancer, potentially ameliorating some side effects?"
  August 2015 ,British Journal of Cardiology,VTE in Primary Care: Patient Management With Rivaroxaban,Get guidance on the practical use of rivaroxaban for the treatment of patients with VTE.
  August 2015 ,Annals of Surgery,Circulating Tumor Cells for Esophageal Cancer Prognosis,Can the detection of circulating tumor cells be used as a prognostic staging tool for nonmetastatic esophageal cancer?
  August 2015 ,BMC Public Health,Predictors of Marked Weight Gain Following Smoking Cessation,Many efforts to quit smoking are hampered by concerns of weight gain. But is amount of weight gained really significant in otherwise healthy patients?
  August 2015 ,Liver International,Pharmacogenetic Testing in Drug-Induced Liver Injury,Can genetic testing determine which patients are at risk for drug-induced liver injury?
  August 2015 ,BMC Anesthesiology,Hypothermia-Induced Impairment of Primary Haemostasis,Low dose desmopressin might have the potential to correct hypothermia-induced primary haemostasis impairment under the influence of aspirin during the perioperative period.
  August 2015 ,BMC Clinical Pathology,Podocalyxin-Like Protein Expression in Pancreatic Cancer,This study examined the clinicopathological prognostic and predictive significance of PODXL expression in pancreatic and periampullary adenocarcinoma
  August 2015 ,Annals of Surgery,Synbiotics in Surgery for Chronic Pancreatitis,Can synbiotics reduce complications in patients undergoing pancreatic surgery for chronic pancreatitis?
  August 2015 ,Cardiovascular Diabetology,Glycemic Variability and Cardiac Autonomic Neuropathy In T2D,Does glycemic variability contribute to the development of cardiovascular autonomic neuropathy in patients with type 2 diabetes?
  August 2015 ,BMC Anesthesiology,Epidural/General Anesthesia During Major Abdominal Surgery,Is the combination of general and epidural anesthesia safe and effective in patients with increased intracranial pressure undergoing elective abdominal surgery?
  August 2015 ,Journal of Glaucoma,Vascular Dysfunction in Diabetes and Glaucoma,Find out about the possible association between the development and progression of open-angle glaucoma in diabetic patients and the vascular components that may contribute to this link.
  August 2015 ,American Journal of Cardiovascular Drugs,Long-term Anti-hypertensive Therapy and Stroke Prevention,Which class of antihypertensive agents is superior in reducing the risk of stroke?
  August 2015 ,Eye,Aflibercept in Wet AMD Beyond the First Year of Treatment,Get up-to-date with the most recent expert recommendations for aflibercept therapy in wet AMD after one year.
  August 2015 ,Journal of the American Geriatrics Society,Depression Screening: Pay-for-Performance Indicator?,"The author argues that adherence to depression screening guidelines in primary care is neither cost effective nor associated with better outcomes, hence shouldn't be considered a performance measure."
  August 2015 ,Arthritis Research & Therapy,"Cost-Effectiveness of Abatacept, Rituximab, and TNFi in RA","When TNFi therapy is failing, which biologic agent is most effective and cost-effective for rheumatoid arthritis patients?"
  August 2015 ,Diabetes,A Thrifty Phenotype Associated With Less Dietary Weight Loss,Learn more about this 'thrifty' phenotype and how it may hinder effective weight loss in obese individuals.
  August 2015 ,Current Opinion in Gastroenterology,Nutritional Therapy in Inflammatory Bowel Disease,What is the role of diet in IBD?
  August 2015 ,Journal of the American College of Cardiology,LVADs: A Rapidly Evolving Alternative to Transplant,Left ventricular assist devices are becoming an increasingly prevalent therapy for patients with Stage D heart failure with reduced ejection fraction.
  August 2015 ,BMC Public Health,Herpes Zoster-Associated Mortality in Europe,Is herpes zoster infection significantly associated with mortality in the elderly?
  August 2015 ,American Journal of Kidney Diseases,"Calciphylaxis: Risk Factors, Diagnosis, and Treatment",High-quality evidence for the diagnosis and management of calciphylaxis is lacking. How should a multidisciplinary team go about treating patients with this disease?
  August 2015 ,Cardiovascular Ultrasound,Markers in Elderly Patients With Severe Aortic Stenosis,"Is there a correlation between echocardiographic and biological markers of elevated LV filling pressures in elderly patients with severe, symptomatic aortic stenosis?"
  August 2015 ,Journal of Medical Case Reports,Switching From Imiglucerase to Miglustat for Gaucher Disease,Can the oral substrate reduction agent miglustat be used successfully as maintenance therapy for Gaucher disease type 1 after initial enzyme replacement therapy?
  August 2015 ,Pediatric Critical Care Medicine,Outcomes Associated With Transfusions in Critically Ill Children,Are RBC transfusions associated with better or worse outcomes in critically ill children?
  August 2015 ,International Journal of Impotence Research,Concordance of Sexual Dysfunction and Dissatisfaction,How does one partner's self-reported sexual function and satisfaction compare with the perception of their spouse?
  August 2015 ,Current Opinion in Nephrology and Hypertension,Pathophysiology of the Chronic Kidney Disease-Mineral Bone Disorder,"How does CKD-mineral bone disorder develop, how common is it, and what is the long-term outcome for patients with the disorder?"
  August 2015 ,BMC Clinical Pathology,Extracellular Vesicles: Potential Applications in Cancer,What role might extracellular vesicles play in cancer? Might they be useful as biomarkers or therapeutic targets?
  September 2015 ,Respiratory Research,Cardiac Safety of Tiotropium in Patients With Cardiac Events,How safe is the HandiHaler in COPD patients who've had a recent cardiac event?
  September 2015 ,BMC Urology,Continence After Early Catheter Removal Post-Prostatectomy,Is there an optimal time point for catheter removal after radical prostatectomy? Find out whether earlier removal impacts urinary continence outcomes.
  August 2015 ,BMC Neurology,Switching From Natalizumab to Fingolimod in RRMS,This study aims to improve our understanding of drug-induced immune changes and potential disease exacerbation during switch-over from natalizumab to fingolimod in treatment of RRMS.
  August 2015 ,Journal of the International Association of Providers of AIDS Care,Self-Report Measures in the Assessment of ART Adherence,Do self-reported adherence measures hold clinical value in screening for poor ART adherence?
  August 2015 ,Cancer Control: Journal of the Moffitt Cancer Center,Impact of Molecular Pathology on Classifying Diffuse Gliomas,Learn how molecular pathology has improved precision in defying and grouping gliomas.
  August 2015 ,BMC Oral Health,Signs and Symptoms Associated With Primary Tooth Eruption,Does teething have a direct relationship to systemic symptoms? And what non-pharmacological approaches are effective in relieving teething symptoms?
  August 2015 ,Liver International,Mechanisms of Non-response to Hepatitis C Therapy,How does cirrhosis affect the response to antiviral therapy in patients with hepatitis C?
  August 2015 ,American Journal of Clinical Dermatology,"Hand Dermatitis: Clinical Features, Prevention and Treatment","Hand dermatitis is a common problem, especially prevalent in occupations such as hairdressers, cleaners, healthcare workers, and others. Read about its etiology and current therapies in this review."
  August 2015 ,Current Opinion in Psychiatry,Adolescent Mental Health Service: Is E-Health the Answer?,"While depression and anxiety are common in young people, many do not seek professional help, due to stigma, expense, or availability. Could online interventions be the answer?"
  August 2015 ,Influenza and Other Respiratory Viruses,"Respiratory Syncytial Virus, an Ongoing Medical Dilemma","There is a large, unmet need for the development of vaccines, prophylactics or therapeutics to help combat RSV. Have there been any clinical trials that look promising?"
  August 2015 ,Oncology Nursing Forum,Fatigue Severity and Depression in Older Patients With Cancer,What clues does fatigue provide in older adults with cancer?
  August 2015 ,Clinical Endocrinology,NAFLD and Age Are Indicators for Atherosclerosis in Obesity,A recent study examines nonalcoholic fatty liver disease and age as independent risk factors for carotid atherosclerosis in obese individuals.
  August 2015 ,Kidney International,Chronic Kidney Disease and Heart Disease,What does the latest research tell us about the connections between CKD and heart disease?
  August 2015 ,BMC Surgery,Total Thyroidectomy in the Treatment of Graves' Disease,This study analyzes the results of surgical treatment of patients with Graves' disease.
  August 2015 ,Endocrine Practice,Anti-obesity Pharmacotherapy in Prediabetes to Prevent T2D,Can these anti-obesity agents effectively prevent prediabetes from developing into type 2 diabetes?
  August 2015 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,ARV Drug Use and HIV Drug Resistance Among HIV+ Black MSM,This report examines ARV drug use and HIV drug resistance among HIV-infected men who have sex with men.
  August 2015 ,Spine,Morbidity and Mortality After Vertebral Fractures,How do the risks of morbidity and mortality compare in vertebral compression fracture patients who received surgical treatment versus those who have been nonsurgically managed?
  August 2015 ,Clinical Gastroenterology and Hepatology,A Proposed New Paradigm for Managing Crohn's Disease,"What is the ""treat to target"" therapeutic strategy in Crohn's disease, and how could it contribute to an improvement in long-term outcomes in patients with the disease?"
  August 2015 ,BMC Musculoskeletal Disorders,Metal Backed Fixed-Bearing Unicondylar Knee Arthroplasties,A new study examines the implant survival rates and functional outcomes in patients treated with this minimally invasive surgical technique for unicondylar knee arthroplasty.
  August 2015 ,BMC Pulmonary Medicine,Staph Aureus and Pseudomonas Infections in Adult CF Patients,How much do specific airway infections impact outcomes in cystic fibrosis?
  September 2015 ,Journal of the American College of Cardiology,Impact of Dual Lipid-Lowering on Coronary Plaque,Find out how ezetimibe and atorvastatin combined impact coronary atherosclerosis in patients undergoing PCI.
  September 2015 ,BMC Ophthalmology,Effectiveness and Costs of Bevacizumab vs Ranibizumab in DME,A new head-to-head trial compares the efficacy and economic value of these two anti-VEGF agents for DME. Which one has the edge?
  September 2015 ,Alimentary Pharmacology & Therapeutics,Effectiveness of Sofosbuvir-based Regimens for HCV Infection,Do sofosbuvir-based regimens bring about sustained virological response in patients with genotype 1 and 2 hepatitis C infection?
  September 2015 ,Journal of Medical Case Reports,Inhibition of IL-1 in Patients With RA and T2DM,Can treatment of rheumatoid arthritis with IL-1 blockade also improve metabolic status in patients with associated Type 2 diabetes?
  September 2015 ,BMC Pulmonary Medicine,Intrabronchial Instillation of Mononuclear Cells in Silicosis,Is bronchoscopic instillation a safe route for bone-marrow derived mononuclear cells in patients with silicosis?
  September 2015 ,Journal of Viral Hepatitis,Therapy for Hepatitis C Genotype 3: Moving Forward,"What drug therapy regimens, with or without interferon, are most effective at treating hepatitis C genotype 3?"
  September 2015 ,BMC Endocrine Disorders,"The Efficacy, Safety of Sitagliptin in the Elderly With T2D",Treatment with the DPP-4 inhibitor sitagliptin may be a safe and effective therapeutic option for elderly patients with type 2 diabetes.
  September 2015 ,Pain Management Nursing,Nonpharmacologic Pain Management in German Nursing Homes,Find out how education on pain-management techniques helps to support patients in managing their pain.
  September 2015 ,Pediatric Nursing,Anger in Adolescent Communities: How Angry Are They?,Learn more about the factors that influence adolescent anger.
  September 2015 ,Chinese Clinical Oncology,Therapies for Melanoma Brain Metastases: Which Drug and When?,Examine the evidence for systemic therapies in patients with active melanoma brain metastasis.
" Open Access Journal of Plastic Surgery,  September 2015 ",ePlasty,Plastic Surgery of the Breast: Keeping the Nipple Sensitive,Find out about the 'unsafe zone' of the breast that should be avoided during reduction mammoplasty in order to preserve nipple sensation.
  September 2015 ,Endocrine Practice,Insulin Sensitizers and Cardiovascular Risk Factors in PCOS,How does treatment with insulin sensitizers affect risk factors for cardiovascular disease in women with PCOS?
  September 2015 ,European Heart Journal,Ablation Strategy for Paroxysmal Atrial Fibrillation,Which ablation strategy provides a longer atrial fibrillation-free period?
  September 2015 ,BMC Anesthesiology,Perioperative Lung Protective Ventilation in Obese Patients,What perioperative protective ventilation strategies should be used on obese patients?
  September 2015 ,Critical Care Medicine,Electronic Tool for Evaluation and Treatment of Sepsis in ICU,Can an electronic tool for sepsis alerts improve compliance with treatment guidelines and clinical outcomes in septic ICU patients?
  September 2015 ,Annals of Oncology,Docetaxel in Metastatic Hormone-Sensitive Prostate Cancer,Does concurrent androgen deprivation therapy plus docetaxel improve survival for some patients with hormone-naive metastatic prostate cancer?
  September 2015 ,Europace,Risk Reduction of Ventricular Tachyarrhythmias in CRT Patients,Find out how mortality risk of CRT-D compares with an ICD alone.
  September 2015 ,Current Opinion in Rheumatology,The Gut Microbiota and Inflammatory Bowel Disease,What features of the mucosal immune system are important in the development and control of inflammatory bowel diseases?
  September 2015 ,AIDS,CD4+ Gain Percentile Curves for Monitoring Response to ART,"Monitoring the percentile curve of CD4+ cell count gain in HIV patients on ART, may help determine subsequent death and virological failure."
  September 2015 ,Journal of the American Board of Family Medicine,Novel Anticoagulants in AF: Primer for the Primary Physician,"Factor Xa inhibitors, direct thrombin inhibitors, aspirin, warfarin--what should you use for AF? Learn their different roles, and how and when to transition from the old to the new, in this guide."
  September 2015 ,Current Orthopaedic Practice,Admission Pathways for Elderly Patients With Hip Fracture,Providing quality and efficient care for these patients may require a multidisciplinary approach.
  September 2015 ,Journal of Cardiovascular Electrophysiology,Sex Differences in Device Therapies in MADIT-CRT,Are women with ischemic heart disease less likely to experience appropriate ICD therapies for ventricular arrhythmias?
  September 2015 ,BMC Oral Health,A Connection Between Sublingual Varices and Hypertension?,"This study suggests that the presence of sublingual varices could be an indicator of hypertension, presenting dentists with a valuable opportunity for screening."
  September 2015 ,Liver International,Non-selective Beta-Blockers May Reduce Risk of HCC,Could beta-blockers help to prevent hepatocellular carcinoma in patients with cirrhosis? This new article explores the research.
  September 2015 ,Seminars in Neurology,The Epidemiology of Posttraumatic Epilepsy,"How great is the risk of posttraumatic epilepsy following traumatic brain injury? And how does it differ, both in presentation and treatment, from other forms of epilepsy?"
  September 2015 ,Current Opinion in Infectious Diseases,Surveillance Systems to Confront Antibiotic Resistance,Read how surveillance systems are essential in combating antibiotic resistance.
  September 2015 ,Alcohol and Alcoholism,Increasing Alcohol Treatment Utilisation Among Inpatients,"Patients with alcohol use disorders who are in the hospital for medical reasons might seem to present an ideal opportunity for intervention, but what type of intervention would be most effective?"
  September 2015 ,Annals of Surgery,Preventing Incisional Hernia in Colorectal Surgery,Incisional hernia is a common complication after colorectal surgery. Would the addition of a prophylactic large-pore polypropylene mesh decrease the incidence of incisional hernia?
  September 2015 ,HIV Medicine,Pre-therapy Inflammation Markers and CD4 Responses to ART,Can pre-ART inflammatory marker levels predicted the CD4 count response to ART?
  September 2015 ,Endocrine Practice,Cinacalcet Treatment in CKD and Hyperparathyroidism,Gain a better understanding of how a regimen of the calcimimetic agent cinacalcet influences plasma adiponectin concentrations in these patients.
  September 2015 ,Current Opinion in Ophthalmology,Anticoagulant and Antiplatelet Drugs in Oculoplastic Surgery,"The perioperative management of patients on anticoagulant or antiplatelet therapy can be challenging, and oculoplastic surgeons must weigh the risks and benefits."
  September 2015 ,European Heart Journal,Effect of the LCZ696 vs Enalapril on Mode of Death in HF,Is LCZ696 superior to enalapril in reducing heart failure deaths?
  September 2015 ,Clinical Journal of Oncology Nursing,Current Perspectives in the Management of Brain Metastases,Find out about novel approaches for treating patients with brain metastases.
  September 2015 ,Journal of the National Cancer Institute,Hematopoietic Transplant Among Elderly With Multiple Myeloma,Has overall survival changed for patients with multiple myeloma who receive hematopoietic stem cell transplantation?
  September 2015 ,BMC Anesthesiology,An Anatomical Study of Lumbar Epidural Catheterization,This study simulated the insertion of epidural catheters in cadaveric specimens to explore the anatomical reasons for epidural catheterization failure.
  September 2015 ,Spine,Epidural Steroid Injection Effects on Postoperative Outcome,Do epidural steroid injections prior to treatment for lumbar spinal stenosis negatively impact treatment outcomes?
  September 2015 ,Annals of Oncology,Stratifying Anticipated Benefit From Anti-Cancer Therapies,Find out more about a new tool from ESMO that's used to determine utility for anti-cancer treatment.
  September 2015 ,Preventing Chronic Disease,Impact of Health Insurance Expansions on Hypertensive Adults,"This study demonstrates that by increasing access to preventive services and lowering out-of-pocket costs of antihypertensive drugs, the Affordable Care Act should improve hypertension management."
  September 2015 ,Clinical Gastroenterology and Hepatology,Pharmacologic Prevention of Pancreatitis After ERCP,Have researchers discovered the best way to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis?
  September 2015 ,Translational Andrology and Urology,Bacille-Calmette-Guerin Non-Responders: How to Manage,What treatment alternatives are available for bladder cancer patients who have failed bacille-Calmette-Guerin therapy?
  September 2015 ,Urologic Nursing,Peyronie's Disease: Overview and Recent Treatment Advances,Learn more about this chronic condition affecting adult males and the negative effects on physical and psychosocial well-being and quality of life.
  September 2015 ,Liver International,Therapeutic Management and Evolution of Chronic HBV,"What type of negative impact does HIV infection have on patients with chronic hepatitis B, and is it changing at all as medications improve?"
  September 2015 ,BMC Psychiatry,Recovery in Lived Experience of Personality Disorders,What does the concept of recovery really mean to people living with personality disorders?
  September 2015 ,European Heart Journal,"Follow-up Duration, Competing Risk and Lifespan-Gain From ICDs",Trial data have shown benefits of these devices but do they make most recipients live longer?
  September 2015 ,American Journal of Public Health,Probability of an Obese Person Attaining Normal Body Weight,Is sustained weight loss without surgical intervention a losing battle for the majority of obese patients?
  September 2015 ,Medicine and Science in Sports and Exercise,Replacing Sitting Time With Different Physical Activities,Find out more about the all-cause and cardiovascular mortality benefits realized by older individuals who replace their sedentary time with a variety of physical activities.
  September 2015 ,Current Opinion in Gastroenterology,Diabetes Associated With Pancreatic Diseases,What does the latest research tell us about the association between diabetes and the risk of pancreatic carcinoma or pancreatitis?
  September 2015 ,Cardiovascular Diabetology,"RAGE and Risk of PAD, Amputation or Death in T2D",What role does the receptor for advanced glycation end products (RAGE) play in the development of PAD and the risk for amputation or death in patients with type 2 diabetes?
  September 2015 ,Annals of Oncology,Adjuvant Trastuzumab Duration for HER-2-Positive Breast Cancer,Find out how the duration of a trastuzumab regimen impacts disease-free survival in HER-2 positive breast cancer.
  September 2015 ,Diabetes Care,Euglycemic Diabetic Ketoacidosis With SGLT-2 Inhibitors,"SGLT-2 inhibitor therapy may be associated with euglycemic diabetic ketoacidosis, and should be used with caution in diabetic patients."
  September 2015 ,Arthritis Research & Therapy,Measuring Disease Activity in Adults With SLE,How can we measure systemic lupus erythematosus disease activity when the disease is known for its variability between patients?
  September 2015 ,International Journal of Impotence Research,Erectile Dysfunction and PDE5 Inhibitor Use,A new study examines the ways in which PDE5 inhibitors may impact the sex lives of older men with erectile dysfunction.
  September 2015 ,American Journal of Epidemiology,Hospitalization Fatality Risk of Influenza A(H1N1)pdm09,This study explores the use of a novel measure--the probability of death associated with H1N1 cases requiring hospitalization--to assess disease severity in the 2009 H1N1 influenza pandemic.
  September 2015 ,European Heart Journal,Role of Neprilysin Inhibitor Combinations in Hypertension,"Get up-to-speed on the mechanism of action, pharmacokinetics, and pharmacodynamics of this novel heart failure drug."
  September 2015 ,The Pediatric Infectious Disease Journal,Neonatal Escherichia coli Bloodstream Infections,Is there an optimal antimicrobial strategy for treating E. coli in the NICU?
  September 2015 ,Cardiovascular Ultrasound,"Carotid Plaque Tissue Characteristics in ACS, Stable Angina","This study demonstrates the utility of the iPlaque system, a novel ultrasound image analysis software that enables the tissue components of carotid plaques to be visualized with high resolution."
  September 2015 ,Journal of the American College of Cardiology,Plaque Characterization by CTA and Acute Coronary Events,Do plaque characteristics by coronary CTA predict mid-term likelihood of acute coronary syndromes?
  September 2015 ,Alimentary Pharmacology & Therapeutics,Progression and Regression of Ulcerative Colitis,What factors are associated with the progression and regression of ulcerative colitis?
  September 2015 ,Journal of the International Association of Providers of AIDS Care,Delaying Initiation of ART for Eligible HIV+ Patients,Why do providers delay ART initiation in clinically eligible patients?
  September 2015 ,BMC Women's Health,Adjuvant Chemo-radiotherapy High Risk Endometrial Cancer,"How safe and effective is sequential chemo-radiotherapy, known as ""sandwich therapy"", for high risk endometrial cancer?"
  September 2015 ,BMC Gastroenterology,Cost-Effectiveness of Sofosbuvir-Based Treatments for HCV,How cost-effective are new sofosbuvir-based regimens compared with other treatment strategies for chronic hepatitis C?
  September 2015 ,Kidney International,The Epigenetics of Acute and Chronic Kidney Disease,"This new article discusses the emerging field of epigenetic therapy, and the evolving role that it could play in the future treatment of renal disease."
  September 2015 ,Journal of Pediatric Psychology,Child Maltreatment and the Adolescent Patient With Severe Obesity,What does this new study tell us about the prevalence and correlates of child maltreatment in adolescents with severe obesity?
  September 2015 ,BMC Neurology,"Latitude, Sun Exposure, and Vitamin D Supplementation in MS","Evidence implicating vitamin D, sun exposure and latitude in the etiology of multiple sclerosis is growing. Do these variables also factor into disease progression and outcome?"
  September 2015 ,BMC Oral Health,Post-Obturation Pain After Non-Surgical Endodontic Treatment,Pain after root canal is common. How does pain incidence and intensity compare after procedures completed in a single visit vs. those completed over multiple visits?
  September 2015 ,BMC Family Practice,Guideline Recommendations About Primary CVD for Older Adults,"Are clinical practice guidelines addressing the specific, more complex needs of older adults when it comes to primary CVD prevention?"
  September 2015 ,HIV Medicine,Monitoring of Kidney Function in HIV-Positive Patients,How often should kidney function be monitored in HIV-positive patients?
  September 2015 ,European Heart Journal,Stroke Following Percutaneous Coronary Intervention,How has the presentation of post-PCI stroke changed in recent years?
  September 2015 ,Medicine and Science in Sports and Exercise,Resistance Training Alters Mitochondrial Function in Muscle,In what ways does resistance exercise impact mitochondrial respiratory function within the skeletal muscle?
  September 2015 ,American Heart Journal,Autonomic Dysfunction in Early Breast Cancer,Gain a better understanding of the clinical importance of autonomic dysfunction -- as a cardiovascular risk marker among breast cancer patients.
  September 2015 ,Rheumatology,Introduction to Statistical Modelling 2,This is the second article in a series on statistical modelling and how to apply it to medicine.
  September 2015 ,U.S. Pharmacist,Pneumococcal Vaccination in Older Adults,New evidence-based recommendations from the ACIP suggest an increase in vaccination rates for older adults receiving pneumococcal vaccines.
  September 2015 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Adherence to Early Antiretroviral Therapy,The use of early ART can be used for HIV prevention in serodiscordant couples. This study examines adherence to this method of treatment as prevention.
  September 2015 ,American Journal of Transplantation,Kidney Transplant Outcomes in HIV-Infected Recipients,How viable is kidney transplantation for patients infected with HIV?
  September 2015 ,Gastroenterology,Update on Fecal Microbiota Transplantation,"What does the latest research tell us about the safety and efficacy of fecal microbiota transplantation for recurrent C. difficile infection, and could it also be used to treat other gastrointestinal diseases?"
  September 2015 ,Clinical Endocrinology,Testosterone After a Glucose and Protein Drink in Obese Boys,A new study examines the effect of a glucose/protein beverage on serum testosterone levels in overweight and obese adolescent boys.
  September 2015 ,Translational Andrology and Urology,Advances in the Treatment of Testicular Cancer,This review examines the newest and most advanced treatments for testicular cancer -- and discusses some of the benefits and risks.
  September 2015 ,Laboratory Medicine,A Nontoxic Case of Vitamin D Toxicity,"Despite consuming well over the intended dose of a Vitamin D supplement, and accumulating toxic serum levels, this patient showed no ill effects and no hypercalcemia, as would be expected. Why?"
  September 2015 ,Journal of the American College of Cardiology,Triple Therapy Among Older Patients With AMI and AF,What's the most appropriate antithrombotic therapy combo for older acute MI patients with atrial fibrillation?
  September 2015 ,BMC Ophthalmology,Corneal Cross-Linking to Halt the Progression of Keratoconus,"Corneal cross-linking is commonly used to help control the progression of keratoconus, but is it equally effective in all patients?"
  October 2015 ,Cardiovascular Diabetology,Changes in CV Risk Markers With Exenatide or Glimepiride,Find out how these two glucose-lowering agents may impact cardiovascular risk markers in type 2 diabetics.
  October 2015 ,Chinese Clinical Oncology,Staging and Response Assessment in Lymphomas,Learn about updates to the 2007 recommendations for lymphoma staging.
  October 2015 ,Liver International,Global Patterns of Hepatocellular Carcinoma Management,"How is hepatocellular cancer treated around the world, and how do treatment patterns affect outcomes?"
  October 2015 ,Cardiovascular Diabetology,The Pleiotropic Effects of Metformin,This commentary discusses the need for well-designed studies that examine the cardioprotective role of the glucose-lowering agent metformin.
  October 2015 ,Annals of Family Medicine,The Collaborative Care Model for Depression in Primary Care,"Despite incentives and intensive training and support, this Collaborative Care program in 75 primary care clinics failed to demonstrate improved outcomes for depression."
  October 2015 ,Eye,Therapies for DME and Rationale for Combination Therapy,"This review evaluates the efficacy of currently available pharmacological treatments for diabetic macular edema, and discusses the potential of combination therapy."
  October 2015 ,Spine,Body Mass Index and Risk for Clinical Lumbar Spinal Stenosis,Is obesity associated with a higher risk of developing lumbar spinal stenosis? A new study looks at the role BMI may play in the development of this condition.
  October 2015 ,European Heart Journal,Endovascular Strategy or Open Repair for Ruptured AAA,What does an endovascular first strategy offer in terms of outcomes - for patients with ruptured aortic aneurysms?
  October 2015 ,Nephrology Dialysis Transplantation,Chronic Kidney Disease and the Risk of Stroke,Find out more about the association between the independent and combined effects of GFR and albuminuria on stroke risk.
  October 2015 ,American Heart Journal,Racial/Ethnic Influences on CV and Renal Events in Diabetes,Which racial and ethnic groups have a higher risk of end stage renal disease?
  October 2015 ,International Journal of Clinical Practice,"Influenza, Influenza-like Symptoms and Their Association With Cardiovascular Risks","There is an association between influenza-like illness and cardiovascular events, but the relationship is less clear with serologically diagnosed influenza."
  October 2015 ,Journal of the American Board of Family Medicine,Success With a Home BP Monitoring Program in Colorado,This article reports on the success of a quality improvement initiative aimed to help primary care practices encourage use of home BP monitoring.
  September 2015 ,BMC Anesthesiology,Nefopam for the Prevention of Perioperative Shivering,Can nefopam safely decrease the risk of perioperative shivering following anaesthesia?
  September 2015 ,Europace,Remote Monitoring Improves Outcome After ICD Implantation,Do heart failure patients participating in remote monitoring have better outcomes than those with standard follow up?
  September 2015 ,Journal of the American Geriatrics Society,Diagnosis and Management of Hypothyroidism in the Elderly,The diagnosis and treatment of subclinical hypothyroidism in elderly individuals may require special considerations. What is the best way to proceed with these patients?
  September 2015 ,Diabetes Care,Using Skype to Improve Diabetes Outcomes in Youth,Videoconferencing via Skype is a novel and useful tool for providing behavioral health care to adolescents with type 1 diabetes and their caregivers.
  September 2015 ,AIDS,Treatment Studies and Biomarkers: The Search for an HIV Cure,This article identifies a safe HIV treatment approach that can identify biomarkers of ART-free remission to aid cure research.
  September 2015 ,Diabetes,Diabetic Nephropathy: Biomarkers for Risk Assessment,A new study examines the potential of microRNAs as a predictive tool for the progression of diabetic nephropathy.
  September 2015 ,Pediatric Pharmacotherapy,Pediatric Vaccine Safety Monitoring,Are vaccines really safe for children? Here's how we know.
  September 2015 ,BMC Family Practice,Psychological Treatments for Depression in Primary Care,A variety of psychological interventions to treat depressive disorders have been developed for use in primary care. Are some approaches more effective than others?
  October 2015 ,Clinical Journal of Oncology Nursing,Nivolumab: Immunotherapy in Malignant Melanoma,"Melanoma rates have been steadily increasing since the 1970s, but cytotoxic chemotherapy generally prolongs survival."
  October 2015 ,Nutrition and Metabolism,Effects of Zinc Supplementation on Serum Lipids,A new review examines how zinc supplementation may impact cholesterol levels and triglycerides. Is it beneficial?
  October 2015 ,Cardiovascular Diabetology,Link Between Metabolic Syndrome and Atherothrombotic Stroke,Is there a connection between metabolic syndrome and multiple atherothrombotic strokes?
  October 2015 ,Journal of the National Cancer Institute,Lack of Angiogenesis in the Formation of Lymph Node Metastases,A new mechanism of treatment resistance to antiangiogenic therapy in adjuvant settings is revealed.
  October 2015 ,Journal of the American Board of Family Medicine,Clinical Needs of Patients With Problem Drug Use,"Primary care physicians are often the first to care for individuals with substance use disorders, who often have multiple coexisting health problems. What factors influence their clinical needs?"
  October 2015 ,American Journal of Pharmaceutical Education,Pharmacy Students' Knowledge Regarding Medical Marijuana,Should pharmacy students be getting additional education on the use and potential adverse effects of medical marijuana?
  October 2015 ,Annals of Oncology,Combining Immunotherapy and Anticancer Agents,"Learn more about the immune-mediated effects of chemotherapy and their clinical relevance, the biological and clinical features of immune checkpoint blockers and more."
  October 2015 ,Wounds,Deep Frostbite Treated With Hyperbaric and Thrombolytics,Find out more about a case of deep frostbite treated with both hyperbaric oxygen and thrombolytic therapies.
  October 2015 ,The Journal of Emergency Medicine,IV Haloperidol vs. IV Metoclopramide for Migraines in the ED,How do these two treatment options for acute migraine headache pain compare in terms of safety and efficacy?
  October 2015 ,American Journal of Transplantation,Transplanting Kidneys From Deceased Donors With Severe AKI,What factors influence success with kidneys transplanted from deceased donors with AKI?
  October 2015 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Disparities in ART Initiation and HIV Virologic Suppression,"Why are patients delaying cART initiation after HIV diagnosis, and how does this affect virologic suppression?"
  October 2015 ,European Heart Journal,Marfan Sartan: A Randomized Placebo-Controlled Trial,What's the benefit of adding Losartan to baseline therapy in patients with Marfan syndrome?
  October 2015 ,Headache,Acute Migraine Treatment in Adults,How do you choose among the numerous options for the pharmacological treatment of acute migraine? This review presents recommendations and discusses considerations in special populations.
  October 2015 ,The American Journal of Gastroenterology,Improving Screening Colonoscopy Quality,Do colonoscopy quality report cards and standards of practice result in an improvement in adenoma-detection rates?
  October 2015 ,Southern Medical Journal,Postconcussive Syndrome Following Sports-Related Concussion,Primary care physicians are often the first to evaluate patients with postconcussion syndrome. This review summarizes both pharmacologic and nonpharmacologic treatment options for PCS in primary care.
  October 2015 ,BMC Neurology,Exercise vs. Usual Care in Stable Immune Mediated Neuropathy,This study aims to evaluate the effect of a tailored home exercise program versus usual care on reducing disability and activity restriction resulting from an inflammatory neuropathy.
  October 2015 ,BMC Ophthalmology,Eylea vs Lucentis for Treatment-Naive Neovascular AMD,A new study compares outcomes between these two drugs in previously untreated patients with neovascular AMD. How do they stack up?
  October 2015 ,The British Journal of Dermatology,Guidelines on Measurement of UV Levels in UV Phototherapy,"These guidelines provide up-to-date, evidence-based recommendations for the safe set-up and calibration of equipment used in ultraviolet radiation therapy."
  October 2015 ,The Journal of Invasive Cardiology,Long-term Outcomes After Real-World Fractional Flow Reserve Use,Does deferral of stenting according to FFR create more favorable long-term outcomes?
  October 2015 ,BMC Dermatology,Perinatal Probiotics to Prevent Allergy Related Disease,Can maternal probiotic supplementation during pregnancy help prevent atopic dermatitis and other allergy-related diseases in offspring?
  October 2015 ,Critical Care,Physician Burnout: Can We Make a Difference Together?,Can a facilitated small-group curriculum intervention prevent burnout for physicians?
  October 2015 ,Seminars in Respiratory and Critical Care Medicine,Advances in Prevention and Treatment of COPD,Learn more about where improvements in the COPD care-continuum are headed.
  October 2015 ,Journal of the American Board of Family Medicine,CKD Guideline Implementation in Primary Care,Are primary care physicians appropriately following guidelines to identify and manage early stage chronic kidney disease? What are the key barriers to guideline implementation?
  October 2015 ,Journal of the American Geriatrics Society,Slowing Conversion From MCI to Alzheimer's Disease,This study suggest that some--but not all--types of antihypertensive medications can reduce the risk of progression to Alzheimer's disease in patients with mild cognitive impairment.
  October 2015 ,International Journal of Clinical Practice,SGLT2 Inhibitors in the Early Treatment of Type 2 Diabetes,"While SGLT2 inhibitors have been targeted at patients with long-standing type 2 diabetes, could they also offer significant benefit in early management?"
  October 2015 ,BMC Oral Health,Effect of Probiotic Chewing Tablets on Early Childhood Caries,"Could chewing a probiotic tablet, as an adjunct to daily use of fluoride toothpaste, help prevent caries in preschool children?"
  October 2015 ,Current Opinion in Nephrology and Hypertension,Novel Therapeutics in Hypertension and Kidney Disease,"Focus on two broad, important concepts emerging in the pharmacology and therapeutics of hypertension and kidney disease."
  October 2015 ,Diabetes,Immunotherapy In Utero for T1D: An Alternative Approach,Could this novel strategy of delivering immunotherapy to the fetus play a role in the prevention of type 1 diabetes?
  October 2015 ,AIDS,Nevirapine Exposure and Response to ART in HIV+ Children,This study investigates the impact of exposure to single-dose nevirapine on virological response in young children initiating ART.
  October 2015 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Convenient HIV Testing Is Attracting Previously Untested Men,Which HIV testing service delivery models attract untested gay and bisexual men?
  October 2015 ,Pediatric Pharmacotherapy,A New Once Daily Product for ADHD,Read about this new alternative for once daily treatment of ADHD.
  October 2015 ,BMC Gastroenterology,Treatment Response in Sofosbuvir-Based Therapy of HCV,Could early virological response be useful in predicting treatment response in sofosbuvir-based combination therapies for chronic hepatitis C?
  October 2015 ,Headache,Pain Catastrophizing in Women With Migraine and Obesity,"Pain catastrophizing is a maladaptive pain coping strategy involving excessive worry, exaggeration, and feelings of helplessness. What's the relation between catastrophizing, obesity, and migraine?"
  October 2015 ,Clinical Endocrinology,Effects of 'Catch-Up' Sleep in Men With Sleep Restriction,What are the metabolic implications of playing weekend 'catch up' on sleep lost during the work week?
  October 2015 ,The Pediatric Infectious Disease Journal,Antibiotic Susceptibility Testing: Present and Future,This article discusses the current practices of antimicrobial susceptibility testing and how technological advancements will change these practices in the future.
  October 2015 ,Malaria Journal,Windows of Selection for Anti-Malarial Drug Treatments,What is the best method for measuring and analyzing true windows of selection for anti-malaria drugs?
  October 2015 ,Alimentary Pharmacology & Therapeutics,Managing Diverticulosis and Diverticular Disease,How could a better understanding of the pathophysiology of diverticulosis and diverticular disease lead to more improved methods of both diagnosis and treatment?
  October 2015 ,European Heart Journal,Gene Therapy in Chronic Ischaemic Heart Failure Patients,Is left ventricular remodeling with gene therapy making a real difference?
  October 2015 ,The American Journal of Gastroenterology,ACG Guideline: Small Bowel Bleeding Diagnosis & Management,Can you manage ongoing overt or occult bleeding effectively? New guidelines from ACG are available here.
  October 2015 ,Skin Therapy Letter,Apremilast for Psoriasis and Psoriatic Arthritis,"An overview of the use, safety, and efficacy of the PDE4 inhibitor apremilast, a promising new systemic therapy for treating psoriatic disease."
  October 2015 ,The Journal of Emergency Medicine,Lactate Level in Critical Patients With Upper GI Bleeding,A serum lactate test upon admission to the ICU may play an important role in predicting outcomes in patients with acute upper GI bleeding.
  October 2015 ,Journal of Clinical Rheumatology,GI Flora and Arthritis Pattern in Spondyloarthropathy,Do patterns of arthritis correlate with gastrointestinal flora?
  October 2015 ,U.S. Pharmacist,Uremic Pruritus Review,Uremic pruritis impacts more than one-third of CKD patients undergoing dialysis. What pharmacotherapeutic options are available for relief of this debilitating condition?
  October 2015 ,Annals of Surgery,Transfusion of Cryopreserved Packed RBCs After Trauma,Is transfusion of cryopreserved packed red blood cells as safe and effective as transfusion of liquid packed red blood cells in trauma patients?
  October 2015 ,Cardiovascular Diabetology,Antidiabetic Treatment With Gliptins and CV Outcomes,What is the relationship between gliptins treatment for type 2 diabetes and cardiovascular outcomes?
  October 2015 ,Translational Lung Cancer Research,Prognosis in Lung Cancer: Evolution of TNM in Molecular Age,Find out about revisions to the TNM classification system -- now in its' 8th edition.
  October 2015 ,Pain Management Nursing,Internet-Based Self-management Program for Persistent Pain,"Find out about the effectiveness of the Chronic Pain Management Program, an 8-week online intervention."
  October 2015 ,AIDS,Initiation of ART at High CD4+ Cell Counts,Should ART initiation begin immediately after HIV diagnosis? This study demonstrates that initiation of cART at a high CD4+ was positively associated with several treatment outcomes.
  October 2015 ,American Journal of Clinical Pathology,HPV Oncogenic mRNA Testing for Cervical Cancer Screening,This study evaluated the viability of a newly approved test for detection of HPV messenger RNA. Is it an effective adjunctive cervical cancer screening method?
  October 2015 ,Clinical Endocrinology,Contralateral Aldosterone Suppression in Aldosteronism,Find out more about the diagnostic significance of contralateral aldosterone suppression for the subtype diagnosis in primary aldosteronism.
  October 2015 ,Urologic Nursing,Nosocomial Bacteremia Secondary to Urinary Catheters,Are male patients at higher risk than females for catheter-associated bacteremia?
  October 2015 ,Journal of the American College of Cardiology,Leadless Cardiac Pacemakers: Back to the Future,What are the less obvious potential benefits of leadless pacemakers?
  October 2015 ,BMC Endocrine Disorders,Effects of a Lifestyle Modification Program in Obese Adults,Bariatric patients who participated in a structured lifestyle modification program achieved significant improvements in cardiovascular risk-related outcomes.
  October 2015 ,European Heart Journal,Impact of Glucose-Lowering Drugs on CV Disease in T2 Diabetes,What's the effect of oral and injectable glucose-lowering drugs on established risk factors and cardiovascular outcomes?
  October 2015 ,The British Journal of Dermatology,Comparing Clinician-Rated Atopic Dermatitis Severity Scales,There are multiple severity outcome measures available for atopic dermatitis. Is one more reliable than the others?
  October 2015 ,The Journal of Invasive Cardiology,RCTs of Conventional Stenting vs Direct Stenting in AMI,Direct stenting is commonly used during PCI for acute myocardial infarction to prevent distal embolization. What's best-practice?
  October 2015 ,The American Journal of Gastroenterology,Selecting Therapeutic Targets in IBD (STRIDE),Can these recommendations change disease course and improve quality of life in patients with Crohn's disease or ulcerative colitis?
  October 2015 ,Laboratory Investigation,MicroRNAs in the Pathobiology of Sarcomas,A better understanding of the role that miRNA-gene signaling and regulatory networks play in various types of sarcomas may lead to improved sarcoma diagnosis and novel therapeutic development.
  October 2015 ,BMC Urology,Adherence on Drug Therapy for BPH-Related LUTS Is Different,How common is the problem of non-adherence among patients prescribed drug therapy for BPH-associated LUTS? Find out how the pattern varies between drug classes.
  October 2015 ,Cardiovascular Diabetology,Delay in Treatment Intensification Increases CV Risk in T2D,Waiting to intensify glucose lowering treatment in type 2 diabetics may be associated with an increased risk of macrovascular events.
  October 2015 ,Current Opinion in Allergy and Clinical Immunology,From Genetics to Treatment of Eosinophilic Esophagitis,Learn how a novel genetics study approach has opened up the understanding of pathogenesis and more for patients with eosinophilic esophagitis.
  October 2015 ,Journal of the American College of Cardiology,Bridging Anticoagulation: Primum Non Nocere,Whether or not to bridge with heparin or other anticoagulants is a common clinical dilemma.
  October 2015 ,BMC Neurology,The Impact of MRI on Ischemic Stroke Detection and Incidence,Will increasing utilization of MRI in stroke diagnosis impact overall epidemiological data on incidence and event rates for stroke?
  October 2015 ,European Heart Journal,Early Performance of a Miniaturized Leadless Cardiac Pacemaker,Learn about the early performance of a novel self-contained miniaturized pacemaker.
  October 2015 ,AIDS,Efficacy of DRV/r Monotherapy Versus DRV/r Triple Therapy,This study evaluates the safety and tolerability of monotherapy with DRV/r versus DRV/r triple therapy.
  October 2015 ,Headache,Sumatriptan Transdermal System in Patients With Nausea,"Nearly half of migraineurs have significant nausea with most attacks, but nausea may also be a side effect of oral triptans. Can a transdermal sumatriptan patch reduce nausea incidence?"
  October 2015 ,Clinical Endocrinology,BMD and Microarchitecture in Endogenous Hypercortisolism,"A new study explores the damaging effects of endogenous hypercortisolism on bone, leading to bone loss and fragility in these patients."
  October 2015 ,Seminars in Neurology,Treatment of Nystagmus,This review summarizes the various acquired and congenital forms of nystagmus. What treatment approaches have been shown to be effective?
  October 2015 ,Europace,Recurrence of Paroxysmal AF After Pulmonary Vein Isolation,"A repeat ablation is performed in around 30 percent of patients due to arrhythmia recurrence, but the strategy for this repeat procedure is not defined."
  October 2015 ,Journal of Pediatric Health Care,Quality of Life Measure for Older Adolescents With Asthma,"This quality of life instrument incorporates substance use, which is an important factor to consider when assessing HRQL in adolescents with asthma."
  October 2015 ,Journal of the American College of Cardiology,Revascularization in Patients With Multivessel CAD and CKD,Find out more about the treatment paradox for patients with chronic kidney disease who need coronary revascularization.
  October 2015 ,Skin Therapy Letter,New Antibiotics for Acute Bacterial Skin Infections,Three new antibiotics have been recently approved for treating acute skin and soft tissue infections. Learn their appropriate use in this brief review.
  October 2015 ,European Heart Journal,Heart Failure in Patients With T2DM Treated With DPP-4i's,"What's the association between heart failure risk and use of sulphonylureas, DPP-4i, and glitazones?"
  October 2015 ,The Nation's Health,"Public Health, Prevention to Play Role in Precision Medicine",How might the practice of precision medicine be applied to prevention and public health?
  October 2015 ,Morbidity & Mortality Weekly Report,Q Fever Among Travelers Who Received Live Cell Therapy,This outbreak of Q fever highlights one of the public health issues associated with medical tourism and unapproved treatments such as live cell therapy.
  October 2015 ,Alimentary Pharmacology & Therapeutics,Gluten Sensitivity in Those Without Celiac Disease,What does the latest research tell us about the different degrees of gluten sensitivity in patients diagnosed with non-celiac gluten sensitivity?
  October 2015 ,Current Opinion in Pulmonary Medicine,Personalized Medicine in Idiopathic Pulmonary Fibrosis,Find out how major advances in our understanding of disease pathobiology and improvements in molecular techniques have changed treatment.
  October 2015 ,BMC Oral Health,Anti-Caries Agents and Dental Caries Among High-Risk Adults,Can aggressive management with remineralization and/or antibacterial agents successfully reduce the severity of dental caries in high-risk patients?
  October 2015 ,BMC Infectious Diseases,Psychological Distress and Non-Adherence to TB Treatment,Does psychological distress influence adherence to TB treatment?
  October 2015 ,Annals of Oncology,Adverse Events in Trials of Immune Checkpoint Inhibitors,Is the reporting quality of immune related adverse events up to par?
  November 2015 ,U.S. Pharmacist,Sexual Dysfunction in Women,"What pharmacotherapeutic options exist to address female sexual dysfunction, and what new therapies are on the horizon?"
  November 2015 ,Alimentary Pharmacology & Therapeutics,Histological Assessment of Disease Activity in UC,What is the most effective way to histologically assess disease activity in ulcerative colitis?
  November 2015 ,European Heart Journal,Effects of Sildenafil on Haemodynamics and Exercise in HF,Does sildenafil reduce pulmonary artery pressures in patients with heart failure and pulmonary hypertension?
  November 2015 ,Chinese Clinical Oncology,Double Hit Diffuse Large B-cell Lymphomas,What novel agents can be incorporated into chemotherapy platforms for this high risk subset of double hit diffuse large B-cell lymphoma?
  November 2015 ,Preventing Chronic Disease,"Relation of Age, Weight to BP Among Blacks and Whites","This study sought to elucidate the complex interplay of race, age, obesity, and hypertension."
  November 2015 ,Current Opinion in Rheumatology,Pathogenesis and Treatment of the Antiphospholipid Syndrome,This article discusses the most recent findings about the pathogenesis and treatment of the antiphospholipid syndrome.
  November 2015 ,The British Journal of Dermatology,Interventions for Rosacea: Updated Cochrane Systematic Review,"What are the available treatments for rosacea, and what evidence supports their use?"
  November 2015 ,Alimentary Pharmacology & Therapeutics,Biomarkers and Personalized Therapy in Lower GI Disorders,"While the treatment of IBS and lower functional gastrointestinal disorders is still based predominantly on symptoms, the identification of biomarkers should further help clinicians to both understand and treat patients in the future."
  November 2015 ,BMC Musculoskeletal Disorders,Bone Marrow Concentrate Treatment Protocol for Knee OA,Bone marrow concentrate injections show promise for the treatment of knee osteoarthritis. Is there an optimal cell dose?
  November 2015 ,BMC Urology,Five-Point Likert Scaling on MRI Predicts Prostate Cancer,Utilizing the five-point Likert scaling system with preoperative MRI findings may be useful in detecting the presence of prostate cancer.
  November 2015 ,The Journal of Invasive Cardiology,Survival Benefit: IABP and Extracorporeal Membrane Oxygenation,Does the concomitant use of IABP with ECMO significantly change survival outcomes?
  November 2015 ,Europace,Depressed Mood Amplifies Cardiac Symptoms in Atrial Fibrillation,Find out how mental health and cardiac symptoms interact.
  October 2015 ,Cancer Control: Journal of the Moffitt Cancer Center,Special Technologies for Ex Vivo Analysis of Cancer,Get up-to-speed on predictive assays and the challenges and values associated with these assays in the clinical setting.
  October 2015 ,BMC Psychiatry,Depression and Anxiety During the Perinatal Period,"This study aims to determine the prevalence of mood, anxiety and stress related disorders among pregnant and postpartum women, particularly those in a high-risk pregnancy."
  October 2015 ,Journal of the American Geriatrics Society,Dairy Consumption and Risk of Frailty in Older Adults,Could a simple dietary change of increasing intake of low-fat dairy products reduce the risk of frailty in older adults?
  October 2015 ,Endocrine Practice,Place of SGLT2 Inhibitors in Treatment Paradigms for T2D,The authors explore the potential role SGLT2 inhibitors could play in the treatment of type 2 diabetes. Where do they fit into diabetes management paradigms?
  October 2015 ,International Journal of Clinical Practice,Should Patients on Long-term Low-Dose Aspirin Receive PPIs?,"Some guidelines recommend co-administration of PPIs in users of low-dose aspirin, but the benefits may not outweigh their potential harms."
  October 2015 ,Nephrology Dialysis Transplantation,Incremental Haemodialysis,Should incremental dialysis and routine assessment of residual renal function be the standard for haemodialysis patients?
  October 2015 ,BMC Oral Health,Effect of MI on Oral Healthcare Attitudes of Parents,Does a motivational interviewing approach give better results than traditional dental health education when delivering oral health information to parents of preschoolers?
  October 2015 ,Oncology Nursing Forum,Pharmacogenomic Testing and Warfarin Management,Learn how advances in pharmacogenomic research can improve anticoagulant management.
  November 2015 ,Cardiovascular Diabetology,Long-term Outcome in Patients With ACS and Dysglycaemia,What role does glucose tolerance play in the prognosis of diabetic patients with acute coronary syndrome and dysglycaemia?
  November 2015 ,American Journal of Cardiovascular Drugs,Non-Vitamin K Antagonist Anticoagulants and Atrial Fibrillation,Find out more about AF risk assessment along with NOAC phase III clinical trials for the prevention of stroke and more.
  November 2015 ,Age and Ageing,Treatment of Lower Urinary Tract Symptoms in Older Persons,Which drugs for lower urinary tract symptoms should be avoided in elderly patients?
  November 2015 ,BMC Family Practice,Technology Based Self-Management Tools for Hypertension,What are patient's attitudes and concerns when it comes to using technology-based tools such as apps or web sites for self-management of hypertension?
  November 2015 ,AIDS,Detecting HIV in Infants Exposed to ART Prophylaxis,HIV diagnosis may be missed in infected infants exposed to postnatal antiretroviral prophylaxis during breastfeeding.
  November 2015 ,Morbidity & Mortality Weekly Report,B Meningococcal Vaccines for Adolescents and Young Adults,This report outlines the latest ACIP recommendations for administration of the MenB vaccine in adolescents and young adults 16-23 years of age.
  November 2015 ,Journal of the American College of Cardiology,Usual Blood Pressure and Risk of New-Onset Diabetes,Do people with elevated BP have a higher risk of diabetes?
  November 2015 ,Alimentary Pharmacology & Therapeutics,FMT for Recurrent C. Difficile Infection Using Frozen Stool,Is fecal microbiota transplant using frozen stool effective in the treatment of recurrent C. difficile infection?
  November 2015 ,Spine,Reoperation Rates for Symptomatic Nonunions in ACDFs,What does this tell us about the rates of reoperation for nonunions after anterior cervical discectomy and fusion?
  November 2015 ,Plastic and Reconstructive Surgery,Capsular Contracture in Implant-Based Breast Reconstruction,Could the use of fenestrated acellular dermal matrices play a role in preventing capsular contracture in implant-based breast reconstructions?
  November 2015 ,Journal of Viral Hepatitis,Alcoholic Hepatitis and HCV Interactions in Liver Disease,"Alcoholic liver disease and chronic HCV infection together are the most common causes of liver disease, and can promote rapid disease progression. How should patients with these concurrent diseases be treated?"
  November 2015 ,Critical Care,"VTE in the ICU: Characteristics, Diagnosis,Thromboprophylaxis",Do all ICU patients need thromboprophylaxis?
  November 2015 ,Nutrition and Metabolism,The Effects of Dietary Restriction in Obese Children,"A new study examines the behavioral, metabolic, and hormonal effects of two different dietary interventions for obesity in children."
  November 2015 ,Cardiovascular Diabetology,Impaired Fasting Glucose and LV Diastolic Dysfunction,Is impaired fasting glucose associated with left ventricular diastolic dysfunction? This study investigates the possible connection in middle-aged adults.
  November 2015 ,Current Opinion in Ophthalmology,Treatment of Giant Cell Arteritis,This article provides an overview of the available treatment strategies for this challenging and potentially blinding condition.
  November 2015 ,HIV Medicine,Biomarkers of Immune Activation and Inflammation in HIV,What is the impact of viral control produced by combination ART on HIV-associated immune activation and inflammation?
  November 2015 ,BMC Infectious Diseases,Trends and Challenges in the Management of Adult Syphilis,The optimal management of syphilis continues to be a controversial topic. This article reviews the latest trends and challenges surrounding the disease.
  November 2015 ,BMC Ophthalmology,Dexamethasone Implants For Macular Edema Due to RVO,Is this a safe and effective therapeutic option for previously untreated patients with macular edema secondary to retinal vein occlusion?
  November 2015 ,Current Opinion in Neurology,Duchenne Muscular Dystrophy: Emerging Tribulations,"While recent studies have shown encouraging results for potential treatments for Duchenne muscular dystrophy, they have also revealed limitations in current trial design for this disease."
  November 2015 ,Annals of Oncology,Elderly Receiving Neoadjuvant Chemoradiation for Rectal Cancer,"What's the impact of age on rectal cancer outcomes, among those treated with chemoradiotherapy?"
  November 2015 ,American Journal of Epidemiology,Relevance of the Metabolically Healthy Obesity Phenotype,"Some obese persons don't develop the metabolic complications of obesity--a phenomenon that's been termed ""metabolically healthy obesity"". But is this phenotype really benign?"
  November 2015 ,Liver International,Chronic Liver Injury Induced by Drugs,"How common is drug-induced liver injury, and how can it best be managed?"
  November 2015 ,Annals of Oncology,BRCA1 and BRCA2 Testing-- Recommendations for Variants,The widespread use of BRCA testing in oncology has raised questions about the clinical importance of unclassified gene variants.
  November 2015 ,Annals of Surgery,Total Pancreatectomy and Islet Autotransplantation Outcomes,What factors predict outcomes after total pancreatectomy and islet autotransplantation?
  November 2015 ,European Heart Journal,Normalization of Testosterone Level and Incidence of MI in Men,Keeping testosterone replacement therapy in check may prevent heart attacks.
  November 2015 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Pre-cART Elevation of CRP and CD4+ T-Cell Immune Activation,Immune activation pre-cART may predict clinical progression when initiating cART.
  November 2015 ,Pain Management Nursing,Three Types of Interventions in Patients with Fibromyalgia,Find out more about the complexity of reducing chronic pain and increasing the quality of life of people with fibromyalgia.
  November 2015 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Poisonings With Suicidal Intent Reported to Poison Centers,This study offers insight into the social and clinical features associated with attempted suicide by intentional self-poisoning among children and young adults.
  November 2015 ,Brain,Let's Be Certain About Sartans,"A recent animal study suggests that sartans can provide neuroprotective effects and improve outcomes after brain injury, but there are many questions still to be answered."
  November 2015 ,Annals of Clinical Microbiology and Antimicrobials,Antimicrobial Activity of PHMG-P Compared to Chlorhexidine,Is polyhexamethylene guanidine phosphate a useful alternative to chlorhexidine as an antiseptic in the treatment and prevention of periodontal disease?
  November 2015 ,Medicine and Science in Sports and Exercise,Short Spurts of Physical Activity and Cardiovascular Health,Could short spurts of moderate to vigorous physical activity help lessen the risk of developing hypertension? Less than 10 minutes may be all it takes.
  November 2015 ,The British Journal of Dermatology,MRI Predicts Outcome in Congenital Melanocytic Naevus,This study demonstrates the value of a single screening MRI of the spine and brain in the evaluation of children with multiple congenital melanocytic nevi.
  November 2015 ,Seminars in Respiratory and Critical Care Medicine,New Pharmacotherapeutic Approaches for COPD,Get the latest data on COPD treatments and how findings can be applied in practice.
  November 2015 ,BMC Public Health,"Cannabis, Other Predictors of Cigarette Use in Young Men",This study looks at the use of cannabis as well as other potential factors which might serve as a gateway to cigarette smoking in young men.
  November 2015 ,Southern Medical Journal,Effect of Body Weight on Dose of Vitamin K Antagonists,"Should body weight be taken into consideration when prescribing warfarin, especially in obese patients?"
  November 2015 ,Alimentary Pharmacology & Therapeutics,Quality of Life in Eosinophilic Esophagitis,How can clinicians better understand and identify patients with eosinophilic esophagitis who are at risk of experiencing poor quality of life?
  November 2015 ,Cardiovascular Ultrasound,Calcium Score and CFVR in Asymptomatic Diabetic Patients,Does the joint analysis of coronary flow velocity reserve and coronary artery calcification in asymptomatic diabetic patients offer a better prognostic value than either test alone?
  November 2015 ,Journal of Glaucoma,Phacoemulsification Alone vs With Viscogonioplasty in PACG,Does phacoemulsification with adjunctive viscogonioplasty offer any additional benefits over phacoemulsification alone?
  November 2015 ,Translational Andrology and Urology,Prevention and Management of Post Prostatectomy ED,This review provides an update on the available prevention and management strategies for postoperative erectile dysfunction following radical prostatectomy.
  November 2015 ,Critical Care Medicine,"Rapid Diagnosis of Bloodstream Infections, Pneumonia, and More",Find out more about rapid pathogen identification in critically ill patients.
  December 2015 ,Environmental Health Perspectives,Lung Cancer and Exposure to Nitrogen Dioxide and Traffic,This meta-analysis examined the relationship of exposure to motor vehicle traffic and incidence of lung cancer.
  December 2015 ,BMC Pulmonary Medicine,Prevention of Exacerbations in COPD With Vitamin D,What benefits could vitamin D supplementation provide vitamin deficient COPD patients?
  December 2015 ,Journal of the American Geriatrics Society,Hypertension in Older Persons: Focus on African Americans,This article reviews the evidence and current guideline recommendations for hypertension treatment in older African Americans. Should a SBP target of less than 140 mmHg continue to be recommended?
  December 2015 ,Annals of Clinical Microbiology and Antimicrobials,Bacillus cereus Blood Stream Infections,"This study investigated the clinical characteristics and antimicrobial susceptibility of Bacillus cereus, a common cause of nosocomial bloodstream infections."
  December 2015 ,Human Reproduction,Reducing Multiple Pregnancies in Advanced Maternal Age,Do experts recommend the elective single-embryo transfer policy in women over the age of 35?
  November 2015 ,Laboratory Medicine,Rh Immunoprophylaxis for Women With a Weak D Phenotype,This review summarizes recommended laboratory practice for managing Rh immunoprophylaxis for RhD-negative women.
  November 2015 ,Journal of the American College of Cardiology,Emergence of Nonobstructive Coronary Artery Disease,The coronary heart disease knowledge gap between genders may be starting to diminish. Find out more.
  November 2015 ,Kidney International,Biomarkers of Rapid CKD Progression in Type 2 Diabetes,Which biomarkers show rapid progression of chronic kidney disease in patients with type 2 diabetes?
  November 2015 ,Nutrition and Metabolism,Changes in Adipose Tissue Proteins and Energy Expenditure,A new study examines how changes in the levels of adipose tissue proteins as a result of weight loss are related to adaptations in energy expenditure.
  November 2015 ,Pediatric Pharmacotherapy,Treatment Options for Head Lice,The increasing frequency of pyrethroid resistance has led to the need for alternative head lice treatments. What other treatment options are available?
  November 2015 ,Respiratory Research,MMP-10 as a Biomarker for Idiopathic Pulmonary Fibrosis,Is MMP-10 a useful prognostic biomarker for idiopathic pulmonary fibrosis?
  November 2015 ,Preventing Chronic Disease,Food Policies to Reduce Obesity and Diabetes Among Adults,"Which food-related policies to prevent obesity and diabetes among adults are working, and which aren't? What's the quality of the evidence?"
  November 2015 ,BMC Ophthalmology,Expert Opinion in Managing Aqueous Deficient Dry Eye Disease,A survey of dry eye experts provides insight into the most commonly used treatment strategies for aqueous deficient dry eye disease.
  November 2015 ,BMC Endocrine Disorders,"Characteristics, Outcomes of T2D Treated With Canagliflozin",Do the benefits of this SGLT2 inhibitor seen in clinical trials translate into clinical practice? A new real-world analysis investigates.
  November 2015 ,Current Opinion in Pulmonary Medicine,Pharmacologic Treatment of Idiopathic Pulmonary Fibrosis,What questions remain about the recently approved medications for the treatment of idiopathic pulmonary fibrosis -- pirfenidone and nintedanib.
  November 2015 ,BMC Public Health,Metabolic Syndrome and Prostate Cancer Risk,Could metabolic syndrome have a protective effect against prostate cancer?
  November 2015 ,Journal of the American College of Cardiology,Effectiveness of LVAD vs Medical Management in Ambulatory HF,Compare LVAD support vs optimal medical management in ambulatory NYHA IIIB/IV patients.
  November 2015 ,Spine,"Ambulatory Surgery Trends in Disc Disorders, Spinal Stenosis",A new study examines the practice patterns of ambulatory spine surgery for intervertebral disc disorders and spinal stenosis. What are the trends?
  November 2015 ,Journal of Viral Hepatitis,"Interferon-free, Direct-acting Antivirals for Chronic HCV",Which types of direct-acting antivirals are the safest and most effective in the treatment of chronic HCV?
  November 2015 ,Plastic and Reconstructive Surgery,Incorporating Single-Stage Implant Breast Reconstruction,"Find out about the benefits of less invasive, single-stage procedures for breast reconstruction after mastectomy."
  December 2015 ,The British Journal of Dermatology,Efficacy of Alternative Treatments for Toenail Onychomycosis,This study investigated the efficacy and safety of a 30% lacquer prepared from Norway spruce in the treatment of onychomycosis. Is it as effective as current oral therapies?
  December 2015 ,Malaria Journal,RBCs as a Biomarker for Anti-Malarial Drug Efficacy,Rigidification of infected RBCs may be used as a biomarker for anti-malarial drug efficacy.
  December 2015 ,Annals of Family Medicine,The Identity Crisis of Osteoarthritis in General Practice,"By observation of real-life consultations using video recordings, common communication issues were revealed when patients and clinicians discussed osteoarthritis."
  December 2015 ,Current Opinion in Infectious Diseases,The Hepatitis C Revolution Part 1,This review article discusses novel hepatitis C virus treatment options in hopes to clarify best available evidence for clinicians treating patients with HCV.
  December 2015 ,Respiratory Research,Iota-Carrageenan Nasal Spray vs Placebo for the Common Cold,Is iota-carrageenan as a nasal spray a useful treatment option for the common cold?
  December 2015 ,BMC Pulmonary Medicine,Factors Involved in Airway Inflammation in Allergic Asthma,This study investigates the contribution of these transcription factors in the pathogenesis of late-phase airway inflammation in adult allergic asthma patients.
  December 2015 ,Headache,Internet-Delivered CBT for Pediatric Headache,Headache is a common complaint of childhood and adolescence. Could an internet-based cognitive behavioral intervention help?
  December 2015 ,BMC Psychiatry,The Early Psychosis Intervention Center (EPICENTER),Can a multi-component psychosocial intervention early in the course of a psychotic illness improve outcomes while reducing costs?
  December 2015 ,American Journal of Epidemiology,Smoking and Risk of Breast Cancer,"This large cohort study examined whether cigarette smoking contributes to breast cancer risk, independent of alcohol consumption or ethnicity."
  December 2015 ,BMC Oral Health,Low-level Laser Application for Masticatory Muscle Pain,Could low level laser application at the points of greatest pain bring relief to patients with chronic temporomandibular disorders?
  December 2015 ,BMC Endocrine Disorders,Thyroid Dysfunction and Dyslipidemia in CKD Patients,Find out more about the prevalence of thyroid and lipid disorders in patients with chronic kidney disease -- and how these complications may contribute to the risk for cardiovascular disease.
  December 2015 ,European Heart Journal,Bone Marrow Cell Injection in Dilated Cardiomyopathy,"Might transplantation of autologous bone marrow mononuclear cells, delivered by intracoronary injection, improve heart function in patients with dilated cardiomyopathy?"
  December 2015 ,Diabetes,Exercise and Weight Loss Improvements After Gastric Bypass,A new study examines the metabolic benefits of weight loss and exercise among patients who underwent Roux-en-Y gastric bypass surgery.
  December 2015 ,BMC Public Health,What Happens When You Tell Someone You Self-injure?,"Should disclosure of non-suicidal self-injury be encouraged in young people, or might negative reactions from family members and friends actually deter them from seeking help?"
  December 2015 ,Chinese Clinical Oncology,Biomarker Driven Strategy for ER+/HER2- Invasive Breast Cancer,Find out more about what's behind the design of the ALTERNATE Trial.
  December 2015 ,Journal of the National Cancer Institute,"BRIP1, BARD1, PALB2, and NBN Mutations in Ovarian Cancer",Do these rare protein-truncating gene variants increase risk of ovarian cancer? The latest research is right here.
  December 2015 ,Translational Lung Cancer Research,Improved Survival Following TKI in Advanced NSCLC--Holy Grail?,INFORM yourself about results from the first RCT to show a significant and clinical meaningful OS benefit in EGFR mutation-positive NSCLC.
  December 2015 ,Alimentary Pharmacology & Therapeutics,Pharmacological Aspects of Anti-TNF Biosimilars in IBD,Will clinicians likely turn to biosimilars for the future treatment of IBD due to their cost savings and comparable efficacy?
  December 2015 ,Annals of Oncology,Why Has Active Immunotherapy Not Worked in Lung Cancer?,Vaccines that rely on active specific stimulation of the host immune system have the potential to trigger durable antitumor responses with minimal toxicity.
  December 2015 ,Laboratory Investigation,Novel Peptide TP508 Mitigates Radiation-Induced GI Damage,A novel peptide may be an effective post-exposure countermeasure for mitigating radiation-induced GI damage and mortality following a nuclear incident.
  December 2015 ,Current Opinion in Pulmonary Medicine,Idiopathic Pulmonary Fibrosis and Lung Cancer,Get up-to-date on the ties that bind these two lethal diseases.
  December 2015 ,European Heart Journal,Combined Perconditioning and Postconditioning in STEMI,Does co-application of remote ischemic conditioning and postconditioning have a more powerful effect on myocardial salvage after STEMI compared with either alone?
  December 2015 ,International Journal of Clinical Practice,Antidiabetic Drugs Added to Metformin and Thiazolidinedione,Is it safe to add a third antidiabetic agent when an optimized metformin plus thiazolidinedione regimen is inadequate? Which combination works best?
  December 2015 ,Environmental Health Perspectives,Racial and Ethnic Disparities in Research Studies,"Although many environmentally related disease disproportionately affect minorities, these groups are much less likely than their white counterparts to be included in studies. How can this be addressed?"
  December 2015 ,BMC Musculoskeletal Disorders,Osteoarthritis and Frailty in Elderly Individuals in Europe,A new study examines the prevalence of OA and frailty among elderly individuals in European countries -- and explores the possible connection between these two conditions.
  December 2015 ,Current Opinion in Gastroenterology,Diet and Microbiome in Inflammatory Bowel Diseases,"What does the latest science tell us about the connections between diet, microbiome and IBD, and how will this knowledge translate into treatments in the future?"
  December 2015 ,Journal of Viral Hepatitis,A Once-daily NS5A Inhibitor in Patients With Genotype 1-4 HCV,What does the latest data tell us about the safety and antiviral activity of GS-5816 in patients with genotype 1-4 hepatitis C infection?
  December 2015 ,U.S. Pharmacist,New Drug Review 2015,"Review the therapeutic profiles of newly approved drugs for psoriasis, type 2 diabetes, opioid-induced constipation, and chronic hepatitis C."
  December 2015 ,Cardiovascular Ultrasound,Inpatient Multimodal Cardiac Imaging Appropriateness,This study examined ordering practices of multiple cardiac imaging modalities used simultaneously in an inpatient environment. Are they being used appropriately?
  December 2015 ,Seminars in Respiratory and Critical Care Medicine,Invasive Aspergillosis: Clinical Aspects and Treatment,"Invasive aspergillosis remains an often fatal, difficult-to-treat infection in immunocompromised patients, but there's hope . . ."
  December 2015 ,Laboratory Investigation,The Role of iNOS in Cholesterol-Induced Liver Fibrosis,Does nitric oxide synthase play a role in cholesterol-induced liver fibrosis? Could its inhibition in cases of liver steatosis have therapeutic benefits?
  December 2015 ,Critical Care,Outcomes of ARDS Survivors Compared With Patients at Risk,This study looks at the quality of life and functional status among ARDS survivors six months after hospitalization compared with those who were at risk but did not develop the condition.
  December 2015 ,Alimentary Pharmacology & Therapeutics,Controlling Chronic GERD,How safe and effective is transoral incisionless fundoplication in comparison to other treatments for the management of chronic GERD?
  December 2015 ,Clinical Endocrinology,"Genetic Etiologies, Outcomes of Pediatric Hypoparathyroidism",This study provides some insight into the genetic etiologies and long-term outcomes of hypoparathyroidism in the pediatric population.
  December 2015 ,Morbidity & Mortality Weekly Report,Estimates of Adults With Indications for PrEP to Prevent HIV,How many adults in the United States are candidates for PrEP as laid out in the 2014 U.S. Public Health Service's PrEP guideline?
  December 2015 ,Menopause,Risk Factors for Hot Flashes in Menopausal Women,What factors are associated with an increased risk of hot flashes in women undergoing the menopausal transition?
  December 2015 ,BMC Family Practice,Generalized Anxiety Disorder in Primary Care,Generalized anxiety disorder commonly presents in primary care. Is it being properly diagnosed and adequately treated?
  December 2015 ,Endocrine Practice,Perspective in Thyroid Extracts for Hypothyroidism,Learn more about the evolution of hormone therapies to treat hypothyroidism -- and where thyroid extracts fit into the mix.
  December 2015 ,Journal of Glaucoma,Comparing Ex-PRESS to Trabeculectomy,How do the outcomes between the Ex-PRESS glaucoma shunt and standard trabeculectomy surgery compare? Is one a better option?
  December 2015 ,American Journal of Kidney Diseases,Proton Pump Inhibitors and Hypomagnesemia in General Population,What's the impact of prolonged PPI use on magnesium levels?
  January 2016 ,BMC Oral Health,Polymorphisms Associated With Periodontitis in T2DM,Do interleukin genotypes and differences in oral microbiota play a role in chronic periodontitis in patients with type 2 diabetes?
  January 2016 ,Spine,Physical Activity for Good Spinal Control With Pain or Not,"What is the relationship between physical fitness, spinal control, and low back pain? This study examines the connection."
  January 2016 ,BMC Pulmonary Medicine,Mortality and Drug Therapy in Patients With COPD,Find out how different pharmacological COPD treatments impact overall survival. Which ones were shown to reduce mortality?
  January 2016 ,Diabetes Care,Depressive Symptoms in Youth With Type 1 or Type 2 Diabetes,"A study finds that symptoms of depression are common among adolescents with diabetes, highlighting the need for routine depression screening in this population."
  December 2015 ,Journal of Medical Case Reports,Rivaroxaban in an Elderly Patient With Pulmonary Embolism,"This case demonstrates that rivaroxaban can be an effective and safe therapeutic choice in the acute phase of pulmonary embolism, even in elderly patients."
  December 2015 ,Neurosurgical Focus,MRI and Neuroimaging Biomarkers for Alzheimer's Disease,"High-field 7-T MRI shows promise as a noninvasive tool for evaluating three markers for Alzheimer's disease: neuroanatomical atrophy, characterization of hypointensities, and microinfarcts."
  December 2015 ,BMC Anesthesiology,Dexamethasone vs Ondansetron for Postop Nausea and Vomiting,Is dexamethasone as safe and effective as ondansetron in preventing postoperative nausea and vomiting in patients undergoing laparoscopic surgery?
  December 2015 ,Menopause,Testosterone for Midlife Women: The Hormone of Desire?,Should testosterone be prescribed for midlife women with sexual dysfunction? This new study looks at the evidence.
  December 2015 ,Respiratory Research,Asthma Characteristics and Biomarkers From the ADEPT Study,Data from the ADEPT study provides insight into the clinical characteristics and biomarkers related to asthma.
  December 2015 ,Critical Care,Ascorbate-Dependent Vasopressor Synthesis,The authors explore the therapeutic potential of adjuvant ascorbate therapy in the management of severe sepsis and septic shock.
  December 2015 ,Alimentary Pharmacology & Therapeutics,Potential Mechanisms of Action of Rifaximin in IBS With Diarrhea,Could resetting microbial diversity via rifaximin lead to a decrease in bacterial fermentation and a reduction in the clinical symptoms of IBS?
  December 2015 ,Journal of the American Geriatrics Society,Treatment of Substance Use Disorders in Older Adults,Should treatment for substance use disorders be approached differently for those over 65 as opposed to younger adults?
  December 2015 ,European Heart Journal,Alirocumab in Heterozygous Familial Hypercholesterolaemia,This study assessed the efficacy of long-term alirocumab treatment in patients with heterozygous familial hypercholesterolaemia who did not adequately respond to standard therapy.
  December 2015 ,International Journal of Clinical Practice,Better Adherence to Antithyroid Drug and Risk of Stroke,"Can good adherence to antihyperthyroid drugs reduce the risk of ischemic stroke in patients with hyperthyroidism, independent of atrial fibrillation?"
  December 2015 ,Current Opinion in Allergy and Clinical Immunology,Allergen Immunotherapy: An Update on Protocols of Administration,Allergen immunotherapy is still the only causal treatment for allergic rhinitis and asthma and new improvements are making it more appealing than before.
  December 2015 ,Journal of Viral Hepatitis,Ledipasvir/sofosbuvir Treatment in Hepatitis C Virus,What are the changes in the apolipoprotein profile of patients with hepatitis C during and after treatment with ledipasvir and sofosbuvir with and without ribavirin?
  December 2015 ,Alimentary Pharmacology & Therapeutics,The Risk of Major GI Bleeding With NOACs,"Are patients taking non-vitamin K antagonist oral anticoagulants at an increased risk for major gastrointestinal bleeding and, if so, why and how could it be prevented?"
  December 2015 ,The Gerontologist,"Lifespan and Healthspan: Past, Present, and Promise","Can we look forward to future increases in lifespan and, importantly, healthspan--the length of a healthy life? The author presents her views on how longer, healthier lives can be achieved."
  December 2015 ,BMC Gastroenterology,Chronic Constipation in the Elderly,"How common is chronic constipation in the elderly, and how is it best diagnosed and managed in this particular age group?"
  December 2015 ,Liver International,Improved Fibrosis Staging in Patients With Liver Disease,How could a better understanding of inflammation-adapted liver stiffness values help to improve both staging and treatment in patients with hepatitis C and alcoholic liver disease?
  January 2016 ,Schizophrenia Bulletin,Aripiprazole vs Risperidone for First-Episode Schizophrenia,Which antipsychotic should be tried first in a patient newly diagnosed with schizophrenia? This study compared the effectiveness and side effects of two commonly used first-line drugs.
  January 2016 ,Current Opinion in Infectious Diseases,The Hepatitis C Revolution Part 2,What additional treatment strategies may be employed in difficult-to-treat hepatitis C patients?
  January 2016 ,Prostate Cancer and Prostatic Diseases,Association of Male Circumcision With Prostate Cancer Risk,Is there a link between circumcision and the risk of developing prostate cancer? A new study explores the possible connection.
  January 2016 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Assessing EM Patient Safety and QI Milestones Using Debates,Find out more about 'EM Debates' -- and learn about the promising role they could play in educating EM residents on patient safety issues and quality improvement.
  January 2016 ,Cardiovascular Diabetology,Acute Hyperglycemia Affects Remote Ischemic Perconditioning,Gain a better understanding of how acute hyperglycemia impacts the cardioprotective effects of remote ischemic preconditioning.
  January 2016 ,Preventing Chronic Disease,Treating High-Need People With Multiple Chronic Diseases,This systematic review looked at different models of care to determine which are most effective for people with multiple chronic conditions and high health-care use.
  January 2016 ,Journal of Cardiovascular Electrophysiology,Primary Persistent AF: A Distinct Arrhythmia Subentity,This study provides new information on a distinct subentity of primary persistent AF. What are its distinguishing characteristics and clinical implications?
  January 2016 ,Critical Care Medicine,Talactoferrin in Severe Sepsis,The administration of oral talactoferrin was explored as a therapeutic approach for severe sepsis-- but data shows that perhaps there is more harm than benefit.
  January 2016 ,Translational Lung Cancer Research,Combining Radiation With Targeted and Immunotherapy,Targeted therapies and immunotherapies have quickly become fixtures in the treatment armamentarium for metastatic non-small cell lung cancer (NSCLC).
  January 2016 ,BMC Gastroenterology,Attributes Associated With Initiating Hepatitis C Treatment,What particular attributes do patients keep in mind when considering decisions about hepatitis C treatment?
  January 2016 ,Alimentary Pharmacology & Therapeutics,Potential Mechanisms of Rifaximin in the Management IBD,"How effective is the antibiotic, rifaximin, in the treatment of different inflammatory bowel diseases?"
  January 2016 ,Clinical Endocrinology,Screening for Thymic and Bronchial Carcinoid Tumors in MEN1,Find out what the available evidence tell us about screening for thymic and bronchial carcinoid tumors in patients with MEN1.
  January 2016 ,European Heart Journal,Who Should Receive Statin Treatment?,How do we decide who to treat or not treat with statins? The author argues that guidelines should include the number-needed-to-treat as a means of aiding the clinical decision.
  January 2016 ,International Journal of Clinical Practice,Empagliflozin/Linagliptin Single-Tablet Combination,"Review the clinical application and safety profile of a new therapeutic option for patients with type 2 diabetes: a once-daily, single-tablet combination SGLT2/ DPP-4 inhibitor."
  January 2016 ,Environmental Health Perspectives,Folic Acid and Creatine to Lower Blood Arsenic,This study suggests that nutritional supplementation can present a low-risk and low-cost treatment option to limit arsenic toxicity in arsenic-exposed populations.
  January 2016 ,Nephrology Dialysis Transplantation,Arteriovenous Fistula as an Intervention in Advanced CKD,Could the arteriovenous fistula play a therapeutic role in patients with advanced CKD?
  January 2016 ,Chinese Clinical Oncology,Overview of NCI Precision Medicine Trials--NCI MATCH and MPACT,"Get a detailed view of the Precision Medicine Initiative, a top priority for the National Cancer Institute."
  January 2016 ,Current Opinion in Neurology,Timing in Neurorehabilitation: Motor Therapy After Stroke,What's the optimal schedule and dosage for motor rehabilitation after stroke? And what factors impact these parameters in the individual patient?
  January 2016 ,Plastic and Reconstructive Surgery,Impact of Rheumatic Disease and Biologics in Plastic Surgery,Find out the best ways to ensure optimal perioperative management of rheumatic patients receiving biologic therapy.
  January 2016 ,Journal of the American College of Cardiology,Making Sense of Statistics in Clinical Trial Reports,"Review the essentials of statistical analysis and key aspects of the reporting of RCTs in this primer, the first of a 4-part series."
  January 2016 ,BMC Family Practice,Bodily Distress Syndrome: A New Diagnosis in Primary Care?,"The authors discuss a new diagnostic category of bodily distress syndrome, which offers a clinically useful, evidence-based path for categorizing patients with functional disorders."
  January 2016 ,BMC Women's Health,Patterns of Domestic Violence and Alcohol Use in Women,"What is the connection between alcohol consumption among women and patterns of domestic violence, and how could a brief intervention help?"
  January 2016 ,Diabetes,Genetic Predisposition to Weight Loss and Regain,This report provides some insights into the genetics of weight loss and unintentional weight regain.
  January 2016 ,Diabetes Care,Acute Kidney Injury Predicts Adverse Outcomes in Diabetes,"Acute kidney injury, albuminuria, and low eGFR may be prognostic indicators of major adverse events in patients with diabetes."
  January 2016 ,Journal of the American College of Cardiology,Complete Versus Lesion-Only Primary PCI,This study sought to determine whether complete revascularization was associated with increased total infarct size compared with an infarct-related artery-only strategy.
  January 2016 ,Morbidity & Mortality Weekly Report,"Tuberculosis Contact Investigations -- US, 2003-2012",Enhancing contact investigation activities is essential to achieve the goal of TB elimination. Are contact investigations in the United States achieving their full potential?
  January 2016 ,American Heart Journal,NT-proBNP and Cardiac Troponin T for CVD Risk Assessment,"This study evaluated the utility of cardiac markers NT-proBNP and TnT as predictors of incident CHD and CVD, independent of established risk factors and ethnicity."
  January 2016 ,Journal of the International Association of Providers of AIDS Care,IAPAC Guidelines for Optimizing the HIV Care Continuum,Barriers across the HIV care continuum prevent people living with HIV from achieving the therapeutic and preventive effects of ART. Read about the interventions that could optimize HIV care.
  January 2016 ,American Journal of Kidney Diseases,Febuxostat for Slowing GFR Decline in CKD With Hyperuricemia,The xanthine oxidase inhibitor febuxostat was shown to be effective in reducing the rate of GFR decline in patients with CKD and asymptomatic hyperuricemia.
  January 2016 ,The American Journal of Gastroenterology,Celiac Disease Risk in Relatives of Patients With the Disease,Are first- and second-degree relatives of patients with celiac disease at an increased risk for developing the disease?
  January 2016 ,Current Opinion in Nephrology and Hypertension,"Nutrition, Vitamin D, and Health Outcomes in Hemodialysis",What kind of impact do nutritional protein supplements have on dialysis patients?
  January 2016 ,Respiratory Research,"Characteristics, Disease Burden and Costs of COPD",A new study looks at the symptomatic burden and disease management costs among primary care COPD patients initiating long-acting bronchodilator therapy.
  January 2016 ,Clinical Endocrinology,Effect of Testosterone Therapy on Cardiac Biomarkers in T2D,In what ways does testosterone therapy impact cardiac biomarkers in men with T2D at high risk of cardiovascular events?
  January 2016 ,Alimentary Pharmacology & Therapeutics,"Risk of Gastric Cancer, Gastrointestinal Cancers and Other Cancers",Are patients taking proton pump inhibitors at an increased risk for developing gastrointestinal cancers?
  January 2016 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,HIV Care Provider Attitudes Regarding Prescribing PrEP,Which HIV providers are more likely to prescribe PrEP?
  January 2016 ,European Heart Journal,ORBIT: A Simple Bedside Score to Assess Bleeding Risk in AF,The authors present a novel bleeding risk score using routinely available clinical information to predict major bleeding in patients with atrial fibrillation.
  January 2016 ,The British Journal of Dermatology,Oxybutynin As a Treatment for Generalized Hyperhidrosis,Is the anticholinergic drug oxybutynin effective in reducing symptoms of hyperhidrosis?
  January 2016 ,BMC Oral Health,Endodontic Flare-ups and Their Relationship to Risk Factors,Are there specific risk factors that might help determine likelihood of flare-ups after root-canal treatment?
  January 2016 ,Journal of the American College of Cardiology,Statistical Controversies in Reporting of Clinical Trials,This paper discuss several controversial statistical issues that are commonly faced in the presentation and interpretation of clinical trial findings.
  January 2016 ,Spine,Comparing Two Lumbar Total Disc Replacements,"The use of these two metal-on-metal implants for lumbar total disc replacement yielded comparable outcomes at five years, according to a new study."
  January 2016 ,HIV Medicine,Liver Toxicity in HIV/HCV Patients Receiving Etravirine,Do HIV/HCV coinfected patients receiving etravirine have an increased risk of liver toxicity?
  January 2016 ,Alimentary Pharmacology & Therapeutics,Optimizing Response to Anti-TNF Therapy in Crohn's Disease,How can clinicians best predict and optimize anti-TNF treatment for their patients with Crohn's disease?
  January 2016 ,The Hospitalist,Hospitalists Around the World,"Hospitalist programs are expanding world-wide, but models of care may be very different than those in the US."
  January 2016 ,Nutrition and Metabolism,Mitochondria: A New Therapeutic Target in CKD,Learn more about the role of mitochondria in the development of CKD -- and its potential as a pharmacological target.
  January 2016 ,Journal for Nurse Practitioners,Musculoskeletal Injections in Primary Care,"This illustrated, step-by-step guide provides instructions and rationale for joint injections that can be administered in the primary care setting."
  January 2016 ,Southern Medical Journal,Coenzyme Q-10 in Human Health: Supporting Evidence?,"CoQ10 is a widely used dietary supplement, especially for cardiovascular conditions. Is there evidence to support claims of its therapeutic benefit?"
  January 2016 ,Seminars in Neurology,Amyotrophic Lateral Sclerosis: Review,"The clinical diagnosis of ALS remains challenging, and while treatment options have expanded in recent years, prognosis is still grim. What's the current state of research?"
  January 2016 ,Journal of the American College of Cardiology,Cost-Effective Strategies for Stroke Reduction in AF,"Although both non-warfarin oral anticoagulants and percutaneous LAAC are initially more costly than warfarin for stroke prophylaxis in patients with AF, might they save cost over the long-term?"
  January 2016 ,Journal of the American Geriatrics Society,Computerized Cognitive Training: Beneficial for Older Adults,"Do computerized ""brain training"" products work to stave off dementia? The authors of this commentary believe in their potential--once you get beyond the marketing and the hype."
  January 2016 ,Journal of Viral Hepatitis,Hepatitis B: 50 Years After the Discovery of Australia Antigen,Read this new article to get a further understanding of the changes in the management of hepatitis B 50 years after the discovery of Australia antigen.
  January 2016 ,The North American Menopause Society (NAMS),Nonhormonal Management of Vasomotor Symptoms of Menopause,What are the most common and effective ways of managing the vasomotor symptoms of menopause without the use of hormones?
  January 2016 ,Skin Therapy Letter,Tavaborole 5% Solution for Toenail Onychomycosis,"The first antifungal in a boron-containing class of drugs with a novel mechanism of action, tavaborole is able to penetrate the nail plate more effectively than other topical agents."
  January 2016 ,Annals of Oncology,Single-Dose Fosaprepitant for the Prevention of CINV,What is the role of neurokinin-1 receptor antagonists in nonanthracycline and cyclophosphamide-based moderately emetogenic chemotherapy regimens?
  January 2016 ,U.S. Pharmacist,Pharmacologic Management of Acute and Chronic Panic Disorder,What are the most effective treatment modalities for panic disorder? Explore the various options in this review.
  January 2016 ,Critical Care Medicine,Timing of Intubation and Clinical Outcomes Adults With ARDS,When should adult patients with ARDS be intubated? Does timing potentially impact outcomes in these patients?
  January 2016 ,BMC Anesthesiology,Sevoflurane Versus Propofol During Cardiac Surgery,Does sevoflurane or propofol exhibit more favorable cardioprotective effects during cardiac surgery?
  January 2016 ,Alimentary Pharmacology & Therapeutics,Screening of Diabetics for NAFLD and Advanced Fibrosis,"What types of non-invasive screening methods are available for NAFLD and liver fibrosis in diabetic patients, and how safe and effective are they?"
  January 2016 ,International Journal of Clinical Practice,Clinical Practice Guidelines for Lung Cancer Screening,Lung cancer screening with low-dose CT remains the subject of controversy. What do current guidelines recommend?
  January 2016 ,Nutrition and Metabolism,High Visceral Fat Area and the Risk of Vitamin D Deficiency,Is there a link between visceral fat area and vitamin D status? A new study explores the possible connection.
  January 2016 ,Nephrology Dialysis Transplantation,Triferic Via the Dialysate in Chronic Hemodialysis Patients,"Triferic administered via dialysate may be effective for delivering iron and maintaining hemoglobin in hemodialysis patients, a new study reports."
  February 2016 ,Current Opinion in Neurology,"Stroke of Undetermined Cause: Workup, Secondary Prevention","The author presents a new concept of embolic stroke of undetermined source (ESUS), defined as patients with cryptogenic stroke and a high probability for a thromboembolic origin."
  February 2016 ,Current Opinion in Rheumatology,Diagnosis and/or Classification of Vasculitis: Different?,Can we separate diagnostic and classification criteria for different forms of vasculitis?
  February 2016 ,Europace,Effect of Cardiac Resynchronization Therapy on Mortality,This study aimed to clarify the action and limitations of cardiac resynchronization therapy in relieving myocardial dysfunction.
  February 2016 ,Spine,Subsequent Lumbar Surgery After Disc Arthroplasty and Fusion,A new study reports on the surgical complications and re-operation rates following these procedures for degenerative disc disease.
  February 2016 ,Alimentary Pharmacology & Therapeutics,Entecavir for Treatment-naive Chronic HBV,"What does the latest research tell us about the safety and efficacy of the antiviral agent, entecavir, for the management of treatment-naive chronic HBV?"
  February 2016 ,BMC Psychiatry,Communication-Focused Therapy for Preschoolers With Autism,"A parent-mediated, communication-focused therapy for young children with autism may provide some symptom improvement--but is it cost effective over the long-term?"
  February 2016 ,Pediatric Pharmacotherapy,New Drug Approvals and Extended Indications for Pediatrics,Which drugs have been newly approved by the FDA for use in pediatric patients?
  February 2016 ,BMC Family Practice,Risk of Exacerbation in COPD,The authors present a predictive model that can identify patients at high risk of acute exacerbation of COPD.
  February 2016 ,European Heart Journal,Molecular Mechanism of Endothelial and Vascular Aging,This review focuses on the latest advances in understanding age-related changes of the cardiovascular and cerebrovascular systems from a molecular perspective.
  February 2016 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,"Triple Rule Out vs CT Angiogram, Stress Test for Chest Pain",How do these evaluation methods for the assessment of chest pain compare in terms of safety and effectiveness?
  February 2016 ,Diabetes Care,Preventing Gestational Diabetes by Lifestyle Intervention,"High-risk pregnant women who participate in a moderate lifestyle intervention may reduce their risk of developing gestational diabetes, a new study reports."
  February 2016 ,Journal of the American College of Cardiology,Challenging Issues in Clinical Trial Design,When should you stop a clinical trial early? When should a protocol be amended? These and other challenging issues in trial design are covered in this paper.
  February 2016 ,BMC Neurology,Effect of Augmenting Cholinergic Function on Gait and Balance,Could augmenting the cholinergic system with a cholinesterase inhibitor improve balance and gait impairment in Parkinson disease?
  January 2016 ,Seminars in Respiratory and Critical Care Medicine,"Trends in the Evaluation, Management of Agitation in the ICU",To sedate or not to sedate? A new study examines the sedation practice patterns for agitation in the ICU.
  January 2016 ,International Journal for Quality in Health Care,An Early Warning for Cardiac Arrest During Laparoscopic Surgery,"Cardiac arrest is a rare, but serious complication of laparoscopic surgery, even in healthy and fit patients. Might bradycardia be a potential red flag?"
  January 2016 ,Annals of Oncology,Pathologic Complete Response as Surrogate End Point for Breast Cancer,How valid is pathologic complete response as a surrogate marker in breast cancer research trials?
  January 2016 ,Breast Cancer Research,Weight Loss and Hormones After Menopause: SHAPE-2 Trial,Research finds that weight loss has a favorable effect on testosterone and estradiol levels in postmenopausal women.
  January 2016 ,The Journal of Invasive Cardiology,Ulnar Artery Interventions Non-Inferior to Radial Approach,Is transulnar access a viable alternative to transradial access in a forearm approach to percutaneous coronary procedures?
  January 2016 ,Liver International,Natural Antioxidants for Non-alcoholic Fatty Liver Disease,What does the latest research tell us about the potential for natural antioxidants to help in the treatment of NAFLD?
  January 2016 ,Spine,Herbal Medicine for Low Back Pain: A Cochrane Review,Are herbal medicines a safe and effective option for sufferers of chronic low back pain?
  February 2016 ,BMC Clinical Pathology,a-Tocopherol-Associated Protein Expression in Breast Cancer,"Might alpha-tocopherol-associated protein, a vitamin E binding protein, function as a tumor suppressor-like factor in breast cancer? What is its association with clinical outcomes?"
  February 2016 ,Journal of Medical Case Reports,Erythema Nodosum With Estrogen Patch for Prostate Cancer,Was the transdermal estrogen this patient received for treatment of prostate cancer the cause of his erythema nodosum?
  February 2016 ,Liver International,Ledipasvir/sofosbuvir for Cirrhotic Patients With Chronic HCV,"How safe and effective is combination antiviral therapy in the treatment of cirrhosis in patients with HCV, and how do patients report on the outcome?"
  February 2016 ,HIV Medicine,Patient Beliefs and Satisfaction When Discontinuing ART,Do patients' beliefs and satisfaction with therapy influence the durability of the first antiretroviral regimen?
  February 2016 ,Age and Ageing,"Efficacy, Safety of Apixaban vs. Aspirin in the Elderly",This study compared the benefits and risks of apixaban as an alternative to aspirin in elderly patients with AF. Can it reduce the risk of stroke without increasing major bleeding?
  February 2016 ,Spine,The Practice of Evidence-Based Medicine in Spinal Care,Evidence-based medicine plays an important role in determining the effectiveness of spinal care interventions.
  February 2016 ,Prostate Cancer and Prostatic Diseases,Preoperative Low T Linked to High-Grade Prostate Cancer,Low preoperative serum testosterone may be a predictor of Gleason score upgrading after radical prostatectomy for prostate cancer.
  February 2016 ,Alimentary Pharmacology & Therapeutics,The Current Treatment of Non-cardiac Chest Pain,"How can different types of non-cardiac chest pain best be managed, both medically and surgically?"
  February 2016 ,Urologic Nursing,Utilization of Hydrophilic-Coated Catheters,"What are the complication rates, utilization rates, and benefits of hydrophilic-coated urinary catheters?"
  February 2016 ,Journal of Pediatric Health Care,Translating Research to Practice for Children With Autism,The number of children with autism is rising. Health care providers must be aware of the best practices to diagnose and manage this growing population.
  February 2016 ,BMC Urology,Degarelix for Prostate Cancer in a Real-World Setting,Do the benefits of this GnRH antagonist for prostate cancer seen in clinical trials translate into real-world clinical practice?
  February 2016 ,Cardiovascular Diabetology,Safety of Empagliflozin in Drug Naive T2D Patients,Could this SGLT2 inhibitor help to successfully manage type 2 diabetes in previously untreated patients -- without increasing cardiometabolic risk?
  February 2016 ,Nutrition and Metabolism,Pioglitazone Plus n-3 Fatty Acids in Metformin-Treated T2D,A new study examines the effects of this combined approach on lipid metabolism in type 2 diabetes patients managed with metformin. Is it beneficial?
  February 2016 ,The Pediatric Infectious Disease Journal,Coadministration of Meningococcal and Other Vaccines,Is it safe to coadminister the quadrivalent meningococcal conjugate vaccine with other routine vaccines?
  February 2016 ,Menopause,"Vaginal Estrogen Use, Urogenital Morbidity in Postmenopause","What does the latest research tell us about vaginal estrogen, its effects on quality of life in postmenopausal women, and how often is it prescribed?"
  February 2016 ,BMC Pulmonary Medicine,Reliever Salbutamol to Measure Exacerbation Risk in COPD,This study evaluates the use of salbutamol as reliever medication to predict the exacerbation risk in COPD. How did it perform?
  February 2016 ,BMC Ophthalmology,Meibomian Gland Dysfunction: Hyperkeratinization or Atrophy?,"In this review, the authors examine the latest evidence on the roles of gland atrophy and ductal hyperkeratinization in the development of meibomian gland dysfunction."
  February 2016 ,Journal of Cardiovascular Electrophysiology,PULSE-SMART: A Novel Smartphone Application,"Can a simple-to-use smartphone app, which utilizes the smartphone camera for pulse detection, accurately discriminate AF from more benign arrhythmias?"
  February 2016 ,Journal of the American Geriatrics Society,Person-Centered Care: A Definition and Essential Elements,"In this position statement, the American Geriatrics Society provides a definition of person-centered care, its essential elements, and barriers to implementation."
  February 2016 ,Current Opinion in Ophthalmology,Glaucoma and Cataract Surgery: Two Roads Merging Into One,"In this review, the benefits and challenges of cataract surgery for managing coexisting glaucoma and cataracts are discussed."
  February 2016 ,Critical Care Medicine,Nutritional Support Guidelines for Critically Ill Patients,A.S.P.E.N. and SCCM provide updated recommendations regarding nutrition therapy in adult critically ill patients.
  February 2016 ,Spine,Evidence-Based Recommendations for Spine Surgery,This article offers a brief summary of some of the latest evidence-based research regarding the treatment of spinal conditions.
  February 2016 ,American Journal of Cardiovascular Drugs,Managing CVD Risk in Chronic Inflammatory Diseases,"An increased risk of CVD has been observed in many chronic inflammatory diseases, not always attributable to traditional risk factors. What might be the mechanism, and how can risk be ameliorated?"
  February 2016 ,Preventing Chronic Disease,"Digital Behavioral Counseling in Prediabetic, CVD Patients",This report estimates the economic benefit of an internet-based behavioral counseling service designed to promote a healthful diet and physical activity for cardiovascular disease prevention.
  February 2016 ,American Journal of Epidemiology,"LDL Cholesterol, hs-CRP Concentrations, and CHD",Might LDL-cholesterol concentrations be a moderator of the contribution of hs-CRP to coronary heart disease?
  February 2016 ,Alimentary Pharmacology & Therapeutics,Alcohol- vs HCV-related Hepatocellular Carcinoma,"Are there major differences in the way alcohol-related vs hepatitis C-related hepatocellular carcinoma develops, and how does this affect future treatment?"
  February 2016 ,Pediatric Pharmacotherapy,New Inhaled Formulations for Treating Asthma in Children,These new inhaled formulations for the treatment of asthma may improve adherence in children and adolescents.
  February 2016 ,International Journal of Clinical Practice,Fibromyalgia: Management Strategies for Primary Care,"What role does the primary care physician play in fibromyalgia management? This review provides insights into diagnosis and management, highlighting the potential role of the PCMH in FM care."
  February 2016 ,Arthritis Research & Therapy,Impact of Certolizumab Pegol in Rheumatoid Arthritis,How effective is certolizumab pegol in the treatment of rheumatoid arthritis? This study takes a look at patient-reported outcomes as well as clinical measures of disease activity.
  February 2016 ,BMC Oral Health,Managing Dental Patients on Novel Oral Anticoagulants,"What should you know before performing dental procedures, especially dental surgery, on patients taking novel anticoagulants?"
  February 2016 ,Wounds,Clinical Experience Using Epidermal Skin Grafts on Wounds,Read about epidermal grafting and its potential roles in wound care and closure.
  February 2016 ,BMC Pulmonary Medicine,Diagnostic Parameters for Obtaining Accurate Data on IPF,"Patient data should be re-evaluated to ensure the accurate collection of epidemiological data on idiopathic pulmonary fibrosis, the authors say."
  February 2016 ,Journal of Glaucoma,Initial Clinical Experience With the CyPass Micro-Stent,"Combined with cataract surgery, the implantation of this novel device effectively lowered IOP in patients with open-angle glaucoma."
  February 2016 ,American Journal of Kidney Diseases,New Treatment Approaches for the Anemia of CKD,What is on the horizon for new therapies in the treatment of anemia in chronic kidney disease?
  February 2016 ,Journal of the American College of Cardiology,CT Angiography for Suspected ACS in the Era of hs-Troponins,Does a diagnostic strategy supplemented by early coronary CT angiography offer an advantage over diagnosis via high-sensitivity troponin assay in suspected acute coronary syndrome?
  February 2016 ,The American Journal of Gastroenterology,Preventing Endoscopic Transmission of Carbapenem-Resistant Enterobacteriaceae,What is the most cost-effective way for clinicians to prevent endoscopic transmission of carbapenem-resistant enterobacteriaceae?
  February 2016 ,Current Opinion in Nephrology and Hypertension,Sodium Glucose Cotransporter 2 Inhibition in Diabetic Kidney,This review explores the therapeutic potential and effects of SGLT2 inhibitors for glycemic control in diabetes.
  February 2016 ,Annals of Oncology,Toxicities of Anti-PD-1/PD-L1 Immune Checkpoint Antibodies,"How do you manage diarrhea, fatigue, rash, and other adverse effects associated with anti-PD-1/anti-PD-L1 therapies?"
  February 2016 ,Pediatric Nursing,Toddler Developmental Delays After Extensive Hospitalization,What factors are associated with the developmental delay of a toddler after extensive hospitalization?
  February 2016 ,Breast Cancer Research,Influence of Obesity on Survival in Early Breast Cancer,Does obesity worsen prognosis in triple negative breast cancer?
  March 2016 ,Malaria Journal,Ethical Aspects of Malaria Control and Research,There are many major ethical issues surrounding the control and elimination of malaria. How do we combat these issues and the disease itself?
  March 2016 ,BMC Psychiatry,Effect of Music Therapy on Symptoms in Schizophrenia,"While the use of music therapy in schizophrenia is not new, this study examines the most recent data on its efficacy, and explores its impact on specific positive and negative symptoms."
  March 2016 ,BMC Ophthalmology,Ranibizumab Combined With Ahmed Valve Implant for Glaucoma,Does intravitreal ranibizumab prior to glaucoma valve implantation provide any added benefits in the treatment of neovascular glaucoma?
  March 2016 ,BMC Surgery,Tumor Location of Pancreatic Ductal Adenocarcinoma,Does tumor location influence prognosis after resection of pancreatic ductal adenocarcinoma?
  February 2016 ,Journal of the American College of Cardiology,Single- vs. Multi-Staged PCI in Multivessel NSTEMI Patients,Which is the preferable strategy in patients with NSTEMI and multivessel coronary artery disease: single-staged or multi-staged PCI?
  February 2016 ,The American Journal of Gastroenterology,Diabetes Mellitus Risk After First-Attack Acute Pancreatitis,"Are patients who have experienced a first-attack of acute pancreatitis at an increased risk for diabetes mellitus and, if so, why?"
  February 2016 ,U.S. Pharmacist,Overuse of PPIs in the Hospitalized Patient,Are PPIs being overused in the hospital setting? This article presents recommendations for their appropriate use.
  February 2016 ,AIDS,Dosing Antiretroviral Medication When Crossing Time Zones,These guidelines discuss how to safely dose antiretrovirals when travelling across time zones.
  February 2016 ,BMC Pulmonary Medicine,Survival in IPF Acute Exacerbations,Steroids are a common approach for the treatment of IPF acute exacerbations -- but are they doing more harm than good?
  February 2016 ,Current Opinion in Allergy and Clinical Immunology,SPLUNC1 Suppression in Chronic Rhinosinusitis,Gain a better understanding of the role of the epithelium-secreted protein SPLUNC1 in the pathogenesis of chronic rhinosinusitis.
  February 2016 ,Breast Cancer Research,Relationship Between HER2 Expression and Trastuzumab Benefit,Will your patient benefit from trastuzumab? New research using quantitative RNA analysis of HER2 may help you find out.
  February 2016 ,BMC Clinical Pathology,Dried Blood Spot Sampling for the Measurement of HbA1c,"Dried blood spot sampling for HbA1c might be a useful alternative to traditional blood collection for people living in rural and remote areas, or the homebound. Does it provide accurate results?"
  February 2016 ,Annals of Oncology,Treating HER2 Lung Cancers: The EUHER2 Cohort,Is trastuzumab beneficial in combination with chemotherapy for advanced HER2-positive advanced NSCLC?
  February 2016 ,Eye,Ranibizumab for the Treatment of Wet AMD,"Ranibizumab for wet AMD has shown success in clinical trials, but are those same results achieved in real-world clinical practice?"
  February 2016 ,BMC Urology,Eviprostat vs Cernilton for Chronic Prostatitis/Pelvic Pain,A new study found no significant difference in the effects of Eviprostat vs the pollen extract Cernilton for chronic prostatitis/chronic pelvic pain syndrome.
  February 2016 ,BMC Endocrine Disorders,Liraglutide Reduces Daytime Sleepiness in Obese Subjects,Could treatment with liraglutide help to reduce excessive daytime sleepiness in obese patients with type 2 diabetes?
  February 2016 ,Nutrition and Metabolism,Miglitol Has Potential as a Therapeutic Drug Against Obesity,"Miglitol, traditionally used as an anti-diabetic drug, may also have a potential therapeutic role in the treatment of obesity."
  February 2016 ,BMC Ophthalmology,Drug Discovery in Ophthalmology,"This review discusses the evolution of ophthalmic drug development, the present challenges, and what the future holds."
  February 2016 ,Current Opinion in Pulmonary Medicine,Pathogenesis and Prevention of Asthma Exacerbations in Kids,Learn more about the mechanisms involved in severe exacerbations of asthma in children -- and find out the best ways to prevent them.
  February 2016 ,The Journal of Emergency Medicine,Target-Specific Oral Anticoagulants in the ED,Find out what emergency providers need to know about the appropriate use of target-specific oral anticoagulants -- and how to effectively manage patients who are taking these agents.
  March 2016 ,AIDS,Tenofovir Exposure and Kidney Function in Women With HIV,This study examines the relationship between TFV exposure and subsequent kidney function in women living with HIV.
  March 2016 ,BMC Neurology,Therapeutic Decompressive Craniectomy in Severe TBI,Is decompressive craniectomy a better option then craniotomy for patients with severe TBI and mass lesions such as subdural hematoma? This study aims to assess the risks and benefits.
  March 2016 ,Diabetes Care,Time for a New Classification System for Diabetes,A new approach to classifying diabetes could better improve the understanding and management of the disease.
  March 2016 ,Breast Cancer Research,Circulating DNA as Biomarker in Breast Cancer,Will analysis of tumor-associated DNA advance personalized medicine in breast cancer?
  March 2016 ,Endocrine Practice,Biosimilars and New Insulin Versions,"Learn about currently available biosimilars, including new insulin versions, and the clinical impact of these products."
  March 2016 ,Plastic and Reconstructive Surgery,Lipofilling Does Not Increase Breast Cancer Recurrence Risk,"Lipofilling for breast reconstruction after mastectomy for breast cancer is not associated with a higher risk of disease recurrence, a new study reports."
  March 2016 ,Nephrology Dialysis Transplantation,ACE Inhibitor/ARB Withdrawal in Advanced Renal Disease,How does withdrawal of ACE inhibitor/ARB treatment affect renal function in advanced chronic kidney disease?
  March 2016 ,Prostate Cancer and Prostatic Diseases,Long-term Survival in Locally Advanced Prostate Cancer,More extensive pelvic lymph node dissection during radical prostatectomy may translate into higher survival rates in patients with locally advanced prostate cancer.
  March 2016 ,Alimentary Pharmacology & Therapeutics,The Practical Management of Acute Severe Ulcerative Colitis,This new article outlines the most current strategies for the management of acute severe ulcerative colitis.
  March 2016 ,BMC Ophthalmology,Dietary Intake in Stargardt Disease and Retinitis Pigmentosa,Gain a better understanding of how these two retinal disorders may be affected by dietary intake. What role does vitamin A status play?
  March 2016 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Transmitted HIV Drug Resistance Among Recently Infected,Transmission of primary HIV-1 drug resistance continues to be an important public health threat. How common is it among newly diagnosed individuals?
  March 2016 ,European Heart Journal,Mortality With Dual Antiplatelet Therapy After Coronary Stents,Is mortality risk with thienopyridine therapy unique to a particular stent type? How does co-administration of aspirin impact the risk?
  March 2016 ,Diabetes,T1D - Reaping the Rewards of a Targeted Research Investment,"A special funding program for type 1 diabetes research has led to many exciting advances in the understanding, prevention, and management of this disease."
  March 2016 ,Annals of Clinical Microbiology and Antimicrobials,Characteristics of Leptospirosis With SIRS,"This study demonstrates that in evaluating a patient with SIRS, the clinical and laboratory findings of leptospirosis may be similar to those of sepsis due to other infectious agents."
  March 2016 ,Journal of the National Cancer Institute,Heart Failure Associated With Trastuzumab in Breast Cancer,Is routine intensive monitoring for heart failure necessary after completion of trastuzumab therapy?
  March 2016 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Electronic Alerts for Frequent ED Users With Opioid Use,The use of electronic alerts may help identify high-frequency users of emergency department care and decrease opioid prescribing for these patients.
  March 2016 ,Preventing Chronic Disease,Public Health and Rare Diseases: Oxymoron No More,"A public health approach to rare diseases may seem unnecessary, or even inapplicable, but this commentary argues that such an approach could greatly benefit affected patients and their relatives."
  March 2016 ,Laboratory Investigation,WNT Signaling in Glioblastoma and Therapeutic Opportunities,WNT signaling plays a crucial role in both CNS development and cancer. Could targeting WNT signaling be a viable therapeutic approach for glioblastoma?
  March 2016 ,International Journal of Clinical Practice,DPP4-inhibitors vs. Sulfonylureas for Patients With T2DM,Are the glucose-lowering effects of sulphonylureas and DPP4 inhibitors equivalent?
  March 2016 ,BMC Infectious Diseases,Detecting Signals of Seasonal Influenza Severity,Can age patterns of influenza-like illness be used to characterize seasonal influenza severity in the United States?
  March 2016 ,Current Opinion in Gastroenterology,Prebiotics and Synbiotics: Improving Gut Health,Could a diet that includes prebiotics and synbiotics help to improve gut health?
  March 2016 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Discontinuation of Initial ART in Clinical Practice,What are the main reasons for stopping the initial regimen of ART in HIV positive patients?
  March 2016 ,American Journal of Pharmaceutical Education,Pharmacogenomics Education: Student Personal Genomic Testing,"A novel participatory education model in which pharmacy students undergo personal genomic testing to enhance their understanding of genotyping may be effective, but remains controversial."
  March 2016 ,Menopause,Efficacy of DHEA on Dyspareunia and Vaginal Dryness,How effective is intravaginal DHEA on moderate to severe dyspareunia and vaginal dryness in menopausal women?
  March 2016 ,AIDS,Maraviroc Improves Cognition in HIV Neurocognitive Disorder,The addition of maraviroc to cART has led to clinically relevant neurocognitive improvement in patients with HIV-associated neurocognitive disorder.
  March 2016 ,Pediatric Critical Care Medicine,Limiting and Withdrawing Life Support in the PICU,Which factors may impact the likelihood of limitation or withdrawal of life support discussions between PICU families and clinicians?
  March 2016 ,Journal of Viral Hepatitis,Work Productivity of Chronic HCV Patients,Do certain medication regimens help to improve the lives of chronic hepatitis C patients so that their work productivity substantially improves?
  March 2016 ,Diabetes Care,The Glucose-Lowering Effect of Metformin Resides in the Gut,"In this report, the authors examine the glucose-lowering actions of metformin formulations -- focusing on the gut-based mechanisms."
  March 2016 ,Annals of Clinical Microbiology and Antimicrobials,Clinical Features of C. Difficile PCR-ribotype 176 Infection,"This study examined the molecular characteristics of C. difficile isolates in patients hospitalized with C. difficile infection, focusing on the features of ribotype 176 strains."
  March 2016 ,Critical Care,Treatment of Gram-Negative Pneumonia in Critical Care,Beta-lactam antibiotics have been the standard treatment approach for gram-negative pneumonia in mechanically ventilated patients -- but have they been overused? What are the alternatives?
  March 2016 ,Annals of Surgery,3D Stereoscopic Viewer for Transanal Endoscopic Surgery,Read about a new 3D stereoscopic visual display that could improve surgical performance during transanal endoscopic surgery.
  March 2016 ,Endocrine Practice,Comparison of Basal Insulin Regimens on Glycemic Variability,Find out how these two insulin regimens compare in terms of glucose control and hospital outcomes among non-critical patients with type 2 diabetes.
  March 2016 ,Medicine and Science in Sports and Exercise,Seasonal Variation in Children's Exercise and Sedentary Time,A study of children's activity behaviors found that more time was spent being sedentary in colder months while physical activity levels were higher in spring and summer.
  March 2016 ,BMC Ophthalmology,Use of Flucinolone Acetonide for Patients With DME,"In patients with diabetic macular edema who do not sufficiently respond to other available therapies, fluocinolone implants may help."
  March 2016 ,American Heart Journal,Statin Use and Outcomes Among Older Patients With CAD,Is intensive statin therapy more effective than moderate therapy in older patients with CAD?
  March 2016 ,BMC Psychiatry,Electronic Self-Monitoring of Mood in Bipolar Disorder,The use of paper-based mood charting instruments to monitor bipolar disorder symptoms is common. Is an electronic self-monitoring tool an acceptable alternative?
  March 2016 ,BMC Ophthalmology,Diabetic Macular Morphology Changes in Early Diabetes,"Using optical coherence tomography, the authors examine the early macular morphological changes in type 1 and type 2 diabetes patients."
  March 2016 ,Clinical Endocrinology,The Impact of NAFLD and MetS on Subclinical Atherosclerosis,"What is the relationship between NAFLD, metabolic syndrome, and subclinical atherosclerosis markers?"
  March 2016 ,Journal of Viral Hepatitis,Grazoprevir Plus PEG-IFN/RBV in Treatment-naive HCV Patients,What does the latest research tell us about the safety and efficacy of grazoprevir therapy in combination with peginterferon and ribavirin for treatment-naive patients with hepatitis C genotype 1?
  March 2016 ,Journal of the American College of Cardiology,Generalizability of SPRINT Results to U.S. Adult Population,How will the new SPRINT recommendations impact the prevalence and number of US adults eligible for antihypertensive therapy?
  April 2016 ,American Journal of Epidemiology,Impact of Universal ICU Staphylococcus Aureus Decolonization,Is ICU decolonization coordinated across hospitals in a region enough to eradicate MRSA completely in that region? This new study investigates.
  March 2016 ,Journal of the American Board of Family Medicine,Translating Lung Cancer Screening Guidelines Into Practice,"New lung cancer screening guidelines, as implemented at one community hospital, resulted in a much higher number of follow-ups than anticipated."
  March 2016 ,Liver International,Fatty Liver Disease and Lifestyle in Youngsters,"Is there an established connection between certain lifestyle choices, such as diet and sleep, and the risk for developing NAFLD in youngsters?"
  March 2016 ,American Heart Journal,Edoxaban vs Warfarin in Patients With Nonvalvular AF,"This study compared 2 dosing regimens of edoxaban, a direct factor Xa inhibitor, with warfarin in patients with non-valvular AF."
  March 2016 ,Eye,Dexamethasone Implant in DME in Real-Life Situations,Are intravitreal dexamethasone implants a safe and effective treatment option for diabetic macular edema? New data from real-life experience sheds some light.
  March 2016 ,Pediatric Pharmacotherapy,Use of Perampanel for Refractory Seizures in Pediatrics,"Read about perampanel, a once-daily alternative to traditional antiseizure drugs for adolescents with refractory seizures."
  March 2016 ,Current Opinion in Psychiatry,Drugs for Mental Health Problems in Intellectual Disability,"Patients with intellectual disability may react differently to pharmacotherapy, and adverse effects are more common. What should you know about prescribing psychotropic drugs to these patients?"
  March 2016 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Safety of HIV PrEP in Individuals With Active Hepatitis B,Is HIV pre-exposure prophylaxis safe for individuals with HBV infection?
  March 2016 ,Spine,100 Most Influential Publications in Cervical Spine Research,This literature review identifies the most important published research regarding the cervical spine.
  March 2016 ,Oncology Nursing Forum,Global Cancer Disparities and the Need for New Initiatives,"In much of the world, a diagnosis of cancer remains a death sentence. How can we overcome global cancer disparities to get individuals the screening and treatment they need?"
  March 2016 ,BMC Pulmonary Medicine,"Clinical, Economic Burden of Idiopathic Pulmonary Fibrosis",What economic and health care burdens does this disease place on patients and the healthcare system?
  March 2016 ,Journal of Viral Hepatitis,Factors Influencing Metabolic Parameters in Chronic HCV,What does this new article tell us about the relationship between menopausal status and metabolic abnormalities and the connection to hepatitis C management?
  March 2016 ,Journal of the American College of Cardiology,Editor-in-Chief's Top Picks From 2015: Part Two,"Review important research from 2015 in areas of cardiac imaging, metabolic disorders, arrhythmia, statistics, valvular heart disease, and vascular medicine."
  March 2016 ,Plastic and Reconstructive Surgery,Monophasic Hyaluronic Acid Filler for Nasolabial Folds,The addition of lidocaine to hyaluronic acid dermal fillers may help alleviate injection pain -- but is it safe?
  March 2016 ,American Journal of Epidemiology,The Potential Trajectory of Carbapenem-Resistant Enterobacteriaceae,"How much of a public health threat is carbapenem-resistant enterobacteriaceae, and what types of infection control practices should be put in place to help prevent it?"
  March 2016 ,Translational Andrology and Urology,The Treatment of ED in Patients With Neurogenic Disease,This review explores the available treatment options for neurogenic erectile dysfunction.
  March 2016 ,Nephrology Dialysis Transplantation,Flu Vaccine and Morbidity and Mortality in Dialysis Patients,End-stage renal disease patients on peritoneal dialysis who received a flu vaccine realized a lower risk of morbidities and mortality than those who were non-vaccinated.
  March 2016 ,BMC Oral Health,Concomitant Antibiotics With Scaling for Periodontitis,Can the addition of concomitant systemic antibiotics to standard periodontal treatment help improve outcomes?
  March 2016 ,Current Opinion in Pulmonary Medicine,Update on Immunotherapy for the Treatment of Asthma,What does the latest research tell us about the use of allergen immunotherapy for asthma?
  March 2016 ,Skin Therapy Letter,Off-Label Uses of Topical Calcineurin Inhibitors,"Studies show that topical calcineurin inhibitors may be effective in treating a variety of skin conditions, and as an alternative to long-term topical corticosteroids. What's the latest evidence?"
  April 2016 ,Alcohol and Alcoholism,Alcohol Consumption and Perception of Attractiveness,"Does consumption of alcohol influence the perception of attractiveness? This study aimed to validate the so-called ""beer-goggles"" effect of social drinking."
  April 2016 ,Age and Ageing,Improving Appropriate Prescribing in Older Patients,What role could pharmacists play in reducing inappropriate prescribing -- particularly among hospitalized dementia patients?
  April 2016 ,Journal of the American College of Cardiology,"CVD and Death, Dementia, and CHD in Patients 80+ Years",Does a delay or prevention of peripheral atherosclerosis result in the reduction or slowing of progression of brain neuropathology and possible incidence of dementia in older persons?
  April 2016 ,Endocrine Practice,Insulin Protocol for Glucocorticoid-Induced Hyperglycemia,This study examines two insulin protocols for treating glucocorticoid-induced hyperglycemia in non-critical hospitalized patients. Which more effectively achieves glycemic control?
  April 2016 ,Alimentary Pharmacology & Therapeutics,Aspirin Is Associated With Lower Indices of Liver Fibrosis,Could aspirin use help to lower the risk of liver fibrosis in patients with liver disease?
  April 2016 ,Current Opinion in Infectious Diseases,New Therapeutic Options for Skin and Soft Tissue Infections,Read about the new approved drugs for the treatment of MRSA complicated skin and soft tissue infections.
  April 2016 ,Journal of the American Geriatrics Society,Role of PCPs for Treating Cataracts and Macular Degeneration,Can primary care physicians improve the quality of life in older patients with uncorrectable vision loss?
  April 2016 ,BMC Oral Health,Caries Remineralisation in Children by Applied Fluoride,"How effective is professionally applied, topical sodium fluoride in remineralizing early enamel caries in children?"
  April 2016 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,ED-Based Intimate Partner Violence Intervention Research,Does 'assessment reactivity' impact the outcomes of research on ED interventions for intimate partner violence?
  April 2016 ,Morbidity & Mortality Weekly Report,"Infection Control Strategies to Prevent TB -- Nigeria, 2015","The success of a pilot CDC program in Nigeria, focused on training health care workers and identifying TB infection control gaps in the healthcare setting, could have global implications."
  April 2016 ,European Heart Journal,The Year in Cardiology 2015: Prevention,The year 2015 gave us many game-changing studies pertaining to CVD prevention. Review the top contenders in this synopsis.
  April 2016 ,Menopause,Vitamin D Supplements and Fall Rate in Postmenopausal Women,Should clinicians be recommending isolated vitamin D supplementation for menopausal women in order to lower the incidence of falls and to improve postural balance?
  April 2016 ,Current Opinion in Rheumatology,Microbiota and Arthritis: Correlations or Cause?,What changes occur in the microbiota of people with arthritis?
  April 2016 ,Diabetes Care,Severe Hypoglycemia Requiring Medical Intervention,Understanding the trends in the incidence of severe hypoglycemia requiring medical attention may help clinicians identify which patients are at higher risk of developing this condition.
  April 2016 ,Journal of the American College of Cardiology,Valve Hemodynamic Deterioration After Transcatheter AVR,What factors are associated with valve hemodynamic deterioration after transcatheter aortic valve replacement? How might the risk be reduced?
  April 2016 ,Clinical Gastroenterology and Hepatology,Prebiotics and Probiotics Before Liver Transplantation,The administration of prebiotics and probiotics prior to liver transplantation may help protect against post-transplant infections.
  April 2016 ,Critical Care,ICAT for Predicting ICU Needs After Thrombolysis in Stroke,The ICAT score may be helpful in predicting the critical care needs of acute stroke patients after IV thrombolysis.
  April 2016 ,Journal of the National Cancer Institute,Preclinical Efficacy of T-DM1 in the Brain Microenvironment,Can T-DM1 overcome resistance to trastuzumab in treatment of brain metastases associated with HER2 positive breast cancer?
  April 2016 ,Endocrine Practice,Levothyroxine Replacement in Obese Hypothyroid Females,Obesity may factor into finding the optimal regimen for levothyroxine replacement in hypothyroid patients after thyroidectomy.
  April 2016 ,Critical Care Medicine,Long-term Outcome Following Tracheostomy in Critical Care,"In this article, the long-term outcomes and complications associated with surgical tracheostomies and percutaneous techniques are examined. How do they compare?"
  April 2016 ,Spine,Smoking Impacts Morbidity Risk After Lumbar Spine Surgery,"The deleterious health effects of smoking are well proven, but could it also negatively impact outcomes after lumbar spine procedures?"
  April 2016 ,BMC Family Practice,Interventions to Improve the Psychological Well-Being of GPs,The stress of workforce and workload issues threatens the mental health and well-being of primary care physicians. Are there any interventions that have proven helpful?
  April 2016 ,U.S. Pharmacist,Dual Antiplatelet Therapy Duration With Drug-Eluting Stents,What is the optimal duration of dual antiplatelet therapy in patients who have drug-eluting stents? The answer may depend on which generation stent was used.
  April 2016 ,The American Journal of Gastroenterology,High Hope for Medical Marijuana in Digestive Disorders,"Does science suggest that medical marijuana could be effective in the treatment of various digestive disorders, and could legalization provide an avenue for further research into its benefits?"
  April 2016 ,International Journal of Clinical Practice,Breakthrough Neuropsychiatric Drugs,"Breakthrough status has recently been granted for novel drugs to treat Parkinson's disease psychosis as well as movement disorders precipitated by antipsychotics, such as tardive dyskinesia."
  April 2016 ,Endocrine Practice,Adjunctive Noninsulin Antihyperglycemic Therapy in T1D,This article provides an overview of the newer anti-hyperglycemic agents available for the adjunctive treatment of type 1 diabetes.
  April 2016 ,Alimentary Pharmacology & Therapeutics,Topical Steroids vs. PPIs for Eosinophilic Esophagitis,How do proton pump inhibitors measure up to topical steroids in the treatment of eosinophilic esophagitis?
  April 2016 ,Critical Care,Hemodynamic Therapy and Postoperative Renal Function,"Goal-directed hemodynamic therapy was not superior to good clinical care in terms of renal outcome after major abdominal surgery, a new study reports."
  April 2016 ,BMC Gastroenterology,Prebiotics in Patients With NAFLD: Trial Protocol,Can prebiotics modulate gut microbiota and hepatic health in patients with NAFLD? Read about a new trial that will find out.
  April 2016 ,Liver International,HCV Council -- Critical Appraisal of Data,This new article summarizes the very latest data regarding best practices for managing patients with chronic hepatitis C virus. What do we learn?
  April 2016 ,Current Opinion in Nephrology and Hypertension,Complications and Management of Hyponatremia,What types of complications are associated with hyponatremia -- and how are they best prevented and managed?
  April 2016 ,American Heart Journal,Revascularization Strategy in Acute MI With Cardiogenic Shock,What is the optimal revascularization strategy in patients with multivessel disease and acute myocardial infarction complicated by cardiogenic shock?
  April 2016 ,Annals of Family Medicine,E-Consultations: Improving Primary Care-Specialty Interface,Can e-consultation referrals increase access to specialty care for underserved populations?
  April 2016 ,BMC Psychiatry,Adherence Therapy vs Routine Care in Schizophrenia,Can a motivational interviewing-based adherence therapy improve medication adherence in people with schizophrenia?
  April 2016 ,The British Journal of Dermatology,Treatment of Actinic Keratosis With Ingenol Mebutate Gel,"A novel topical medication, produced from the sap of a common plant, shows promise in clearing actinic keratosis."
  April 2016 ,Laboratory Investigation,Loss of Antigenicity With Tissue Age in Breast Cancer,Breast cancer specimens are often archived for many years for research or follow-up purposes. Do expression and detection of target biomarkers degrade over time in FFPE tissues?
  April 2016 ,Modern Pathology,Immune Microenvironment of Breast Ductal Carcinoma In Situ,This study investigates the immunobiology of DCIS breast cancers. How does the antitumor immune response evolve as tumors progress from in situ to invasive and then metastatic lesions?
  April 2016 ,Clinical Endocrinology,Surgically Ablated Thyroid Cancer Does Not Need Adjuvant RAI,"In patients with intermediate-risk thyroid cancer that has been surgically ablated, adjuvant radioiodine therapy may not be necessary."
  April 2016 ,U.S. Pharmacist,Aspirin for Primary Prevention of Cardiovascular Disease,The use of aspirin for primary prevention in patients with no history of cardiovascular disease remains controversial. Do the benefits outweigh the risks?
  April 2016 ,The American Journal of Gastroenterology,Simeprevir and Sofosbuvir to Treat Chronic HCV Genotype 1,"Is the combination of simeprevir and sofosbuvir well-tolerated and effective in patients with hepatitis C genotype 1, and does its ""real world"" results mirror those in the clinical trials?"
  April 2016 ,BMC Infectious Diseases,Periprosthetic Joint Infections Controlled by Daptomycin,"This protocol uses daptomycin-impregnated cement combined with systemic daptomycin, to safely and effectively treat periprosthetic joint infections caused by methicillin-resistant Staphylococci."
  April 2016 ,BMC Urology,"Prognostic Factors, Risk Stratification in CRPC on Docetaxel",Could certain prognostic factors help predict overall survival in castration-resistant prostate cancer patients treated with docetaxel?
  April 2016 ,Cardiovascular Diabetology,Efficacy of Sitagliptin in Diabetes With High CVD Risk,Does sitagliptin provide cardioprotective effects? This study examines the benefits among type 2 diabetes patients at high risk for cardiovascular disease.
  April 2016 ,Clinical Endocrinology,Endocrine Disorders in HIV+ Women Associated With Viral Load,New research looks into the prevalence of endocrine abnormalities in HIV-infected women and the association between endocrine dysfunction and viral load.
  April 2016 ,U.S. Pharmacist,Monoclonal Antibodies for Hypercholesterolemia,"Learn about treating hypercholesterolemia with the recently approved PCSK9 inhibitors in this review. When should they be used, and what are their risks and benefits?"
  April 2016 ,Diabetes,Maternal Glucose and Birth Weight in Obese Women With T2D,"Maternal glucose, fatty acids, and birth weight -- what is the relationship? This study examines the possible connection among obese women with pre-gestational type 2 diabetes."
  April 2016 ,BMC Endocrine Disorders,Adrenocortical Cancer: Mortality and Prognostic Markers,What do we know about this rare cancer? Could certain markers help predict prognosis?
  April 2016 ,Breast Cancer Research,Targeting CDK 4/6 in ER-Positive Breast Cancers,"Learn about small molecule CDK4/6 inhibitors in clinical development. Are they effective, safe, and tolerable?"
  April 2016 ,BMC Pulmonary Medicine,BF Spiromax Compared to BF Turbuhaler for Persistent Asthma,A new study compares the use of two inhalers for delivering budesonide and formoterol in patients with persistent asthma. How do they stack up?
  April 2016 ,Current Opinion in Pulmonary Medicine,An Update on Pharmacologic Management of COPD,What's new in drug treatments for COPD? Find out the most recent developments in pharmacologic management of this disease.
  April 2016 ,Current Opinion in Gastroenterology,Nutritional Consequences of Long-term Acid Suppression,"Could the long-term use of proton-pump inhibitors cause nutritional consequences, such as vitamin deficiencies? This new article investigates."
  April 2016 ,Alimentary Pharmacology & Therapeutics,Direct-acting Antivirals in New Era of Hepatitis C Therapy,How are the newer direct-acting antivirals changing the landscape of hepatitis C treatment?
  April 2016 ,Nutrition and Metabolism,Partially Hydrolyzed Guar Gum in the Treatment of IBS,The prebiotic properties of partially hydrolyzed guar gum may help alleviate some symptoms of irritable bowel syndrome.
  April 2016 ,American Journal of Pharmaceutical Education,Role of Clinical Practice Guidelines in Pharmacy Education,"While clinical practice guidelines are certainly important to health care, does taking them at face value undermine clinical growth for pharmacy students?"
  April 2016 ,Skin Therapy Letter,"Dupilumab, a Monoclonal Antibody for Atopic Dermatitis","Learn about a novel biological therapy for atopic eczema, dupilumab, which is on a fast-track to FDA approval. How is it clarifying our understanding of the pathogenesis of this chronic disease?"
  April 2016 ,BMC Oral Health,Duration of IV Zolendronate and Success of Endodontic Therapy,Does the duration of bisphosphonate therapy impact the success of root canal treatment in patients requiring endodontic procedures?
  April 2016 ,Journal of the American Geriatrics Society,Canagliflozin in Individuals Aged 75 and Older With T2DM,Is the SGLT2 inhibitor canagliflozin safe to use in elderly diabetic patients?
  April 2016 ,BMC Neurology,Pain Management for Neuropathic Pain in Fabry Disease,Debilitating neuropathic pain is one of the key features of Fabry disease. What pain management strategies may be most effective?
  April 2016 ,Wounds,Plastic Surgery Myths: Postop Management of Surgical Drains,What factors should be considered before pulling a postoperative drain?
  April 2016 ,BMC Anesthesiology,Dexketoprofen/Tramadol 25 Mg/75 Mg,This new oral combination of two analgesics with different mechanisms of action may be very useful in managing post-op pain.
  May 2016 ,Alimentary Pharmacology & Therapeutics,Alginate vs Placebo as Add-on Therapy in Reflux Patients,Can alginate reduce persistent reflux symptoms despite treatment with once-daily PPI?
  May 2016 ,Journal of the National Cancer Institute,Continuous Estrogen Plus Progestin and Endometrial Cancer,Does addition of progestin to estrogen therapy really reduce risk of endometrial cancer? Find the answer here.
  May 2016 ,Gastroenterology,Radiofrequency Ablation in Patients With Barrett Esophagus,"Is radiofrequency ablation considered to be a safe and effective treatment for patients with Barrett esophagus with low-grade dysplasia, and does it prevent progression to esophageal cancer?"
  May 2016 ,Clinical Endocrinology,Bone Changes After Bisphosphonate Therapy 'Drug Holiday',Understanding the bone changes that occur after discontinuing bisphosphonate therapy for osteoporosis may help clinicians decide the optimal time to resume treatment.
  May 2016 ,The American Journal of Gastroenterology,Food: The Main Course to Wellness and Illness in IBS,"How will dietary treatments for IBS evolve in the future? This new article takes a look at ""functional foods"" and their role in alleviating symptoms of the syndrome in patients."
  May 2016 ,Menopause,Compounded Non-FDA-approved Menopausal Hormone Therapy,"What is compounded hormone therapy, are there specific risks with it, and how often is it being prescribed for menopausal women?"
  May 2016 ,Translational Lung Cancer Research,Immunohistochemistry to Predict Anti-PD1/PDL1 Activity,Which patients with lung cancer will respond to anti-PD-1/PD-L1 therapies?
  May 2016 ,Pediatric Critical Care Medicine,Pharmacotherapies in Cardiac Critical Care,What do we know about the currently available sedative and analgesic agents for pediatric cardiac ICU patients?
  May 2016 ,Clinical Gastroenterology and Hepatology,Efficacy of PPIs in Patients With Esophageal Eosinophilia,Do proton pump inhibitors induce clinicohistologic remission in patients with symptomatic esophageal eosinophilia?
  May 2016 ,Journal of the American College of Cardiology,Should TAVR Be Performed in Nonagenarians?,An increasing number of nonagenarians present with severe aortic stenosis. Can they benefit from transcatheter aortic valve replacement?
  May 2016 ,Cancer Control: Journal of the Moffitt Cancer Center,Prognostication of Survival in Patients With Advanced Cancer,Prediction of survival in advanced cancer is often overestimated. Which methods predict survival more accurately?
  April 2016 ,BMC Gastroenterology,Optimizing Biologic Treatment in IBD,"What parameters should be monitored during induction therapy, maintenance therapy, and after loss of response in patients with IBD?"
  April 2016 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Recommendations for Prehospital Care in Acute Stroke,This article provides guidance for EMS personnel on the prehospital evaluation and treatment of patients with suspected stroke.
  April 2016 ,Liver International,Non-invasive Models of Predicting Fibrosis in NAFLD,How accurate and reliable are non-invasive methods of predicting fibrosis in patients with NAFLD?
  April 2016 ,Arthritis Research & Therapy,CT-P13 vs Reference Infliximab in Ankylosing Spondylitis,Is CT-P13 a safe and effective treatment option for patients with ankylosing spondylitis?
  April 2016 ,Journal of Glaucoma,Drug-Induced Bilateral Secondary Angle-Closure Glaucoma,Find out which types of drugs may play a role in the development of drug-induced bilateral secondary angle-closure glaucoma.
  April 2016 ,BMC Psychiatry,Meeting Information Needs for Patients With PTSD,The authors developed a patient decision aid designed to help educate and inform patients with PTSD as to their treatment options.
  April 2016 ,Wounds,Amniotic Membrane Allograft for Chronic Diabetic Foot Ulcers,Is dehydrated amniotic membrane allograft safe and effective in the management of chronic diabetic foot ulcers?
  April 2016 ,The British Journal of Dermatology,Propranolol in the Treatment of Infantile Haemangiomas,"This large cohort study assesses the safety and efficacy of oral propranolol for treatment of infantile hemangioma, analyzing data from 39 European centers."
  April 2016 ,Modern Pathology,microRNA-10b Is a Prognostic Biomarker for Melanoma,The authors sought to identify which microRNAs might have prognostic value in melanoma. Is there a place for microRNA analysis in stratifying melanoma for therapy?
  May 2016 ,Skin Therapy Letter,Nivolumab for Metastatic Melanoma,"This brief profile gives an overview of nivolumab, a human monoclonal antibody against PD-1 receptor, approved for treatment of unresectable or metastatic melanoma that is unresponsive to other drugs."
  May 2016 ,Cardiovascular Ultrasound,Strain-time Curve Analysis by Echocardiography in CRT,"This echocardiographic study analyzed the contraction pattern of CRT patients with the aim of identifying predictors of non-response, despite favorable pre-procedural characteristics."
  May 2016 ,Cardiovascular Diabetology,CVD Risk Associated With Antidiabetic Drugs in T2D Patients,"Certain anti-diabetic drugs have been linked to an increased risk of cardiovascular disease, leading clinicians to weigh the risks and benefits."
  May 2016 ,Journal of the American College of Cardiology,Infarct Size and Outcomes Following Primary PCI,This study looked at the prognostic value of infarct size in patients with ST-segment elevation myocardial infarction.
  May 2016 ,Current Opinion in Nephrology and Hypertension,Management of Bone Mineral Disorders in CKD and ESRD,What are the latest developments in the management of mineral bone disorders in patients with CKD and ESRD? This new article summarizes the latest research.
  May 2016 ,Annals of Clinical Microbiology and Antimicrobials,Mortality Predictors of Staphylococcus aureus Bacteremia,What factors might influence mortality and outcome in patients with S. aureus bacteremia?
  May 2016 ,Journal of Glaucoma,Ocular Hypertension Following Intravitreal Anti-VEGF Therapy,Ocular hypertension can be a potential side effect of treatment with anti-VEGF agents. What role does intraocular nitric oxide have in the development of this complication?
  May 2016 ,BMC Oral Health,Do Ball-ended Probes Cause Less Damage Than Sharp Explorers?,This study aimed to compare ultrastructural defects caused by ball-ended probes with damage by sharp explorers during tactile exams of primary teeth.
  May 2016 ,BMC Psychiatry,Guided Tapering of Antidepressants During Pregnancy,Is guided tapering of SSRIs with concurrent preventive cognitive therapy feasible as an alternative to continuation of SSRIs during pregnancy?
  May 2016 ,BMC Anesthesiology,Guidelines for the Management of Neuropathic Pain,The management of neuropathic pain can be challenging. Are these guidelines any help in optimizing patient care?
  May 2016 ,Annals of Surgery,Neoadjuvant Chemoradiotherapy and Surgery in Rectal Cancer,A longer waiting interval between the end of neoadjuvant chemoradiotherapy and surgery may increase the rate of pathological complete response in rectal cancer.
  May 2016 ,Current Orthopaedic Practice,Fracture Healing: An Overview of Existing Concepts,Gain a better understanding of the fracture healing process -- and find out about the current options for managing patients with fractured bones.
  May 2016 ,The Pediatric Infectious Disease Journal,Global Vaccine Safety Assessment,"Vaccine safety research is a key component of effective, responsible and sustainable immunization programs. What are the challenges and benefits we are facing with vaccine safety research?"
  May 2016 ,BMC Urology,Urinary Studies to Monitor Bladder and Urological Diseases,The biomarkers contained in urine can provide important clues regarding the diagnosis and prognosis of urological diseases.
  May 2016 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,First-Pass Success in Pediatric Intubation in the ED,Which factors may predict a successful first intubation attempt in children?
  May 2016 ,Arthritis Research & Therapy,Genome Association of Anti-TNF Response in Patients With RA,Can genetic biomarkers predict anti-TNF response in RA patients?
  May 2016 ,Plastic Reconstructive Surgery-Global Open (PRS Global Open),Inframammary Fold Reconstruction: A Biomechanical Analysis,A head-to-head comparison of fixation methods for inframammary fold reconstruction found that an absorbable anchor system is biomechanically superior to the standard suture method.
  May 2016 ,Emerging Infectious Diseases,C. difficile Within and Outside Healthcare Settings,This study compares the transmission rates of C. diff infection among patients in the hospital with persons in the community.
  May 2016 ,Current Opinion in Rheumatology,Biomarkers to Guide Clinical Therapeutics in Rheumatology?,Better biomarkers are needed to guide clinical decision making in rheumatology.
  May 2016 ,Current Opinion in Neurology,Recent Advances in Status Epilepticus,This review discusses advances in the understanding of the mechanisms of status epilepticus and its current treatment approaches.
  June 2016 ,Current Opinion in Psychiatry,Psychosis Induced by Amphetamines,"Recent studies on amphetamine-induced psychosis provide updated knowledge about precipitating factors, the complex relationship between amphetamine-induced and primary psychosis, and treatment."
  June 2016 ,Europace,Infection Control in Implantation of CIEDs,CIED-related infection can be a devastating complication of this procedure. This review presents the current evidence for perioperative prophylaxis and protocols for infection control.
  June 2016 ,Brain,Amyloid Biomarkers: Pushing the Limits of Early Detection,"Recent studies involving amyloid biomarkers are yielding important insights into the dynamics of Alzheimer's disease, as well as revolutionizing the design of clinical trials."
  June 2016 ,Seminars in Neurology,Promising Oral Compounds for the Treatment of MS,What new agents are under investigation for the treatment of MS? This review highlights promising oral compounds and dietary factors that are in the early development stages.
  June 2016 ,European Heart Journal,Coronary CTA for Identifiying Ischemia-Causing Lesions,"Utilizing coronary CTA, this study examined the relationship between coronary plaque volumes and lesion-specific ischemia."
  June 2016 ,Journal of Medical Case Reports,Deoxyribonuclease I in End-stage Alzheimer's Disease,Might the endonuclease DNase 1 be a beneficial treatment for severe cognitive impairment in Alzheimer disease? The response in this patient was very encouraging.
  June 2016 ,European Heart Journal,Left Ventricular Heart Failure and Pulmonary Hypertension,"This review examines the complex pathophysiology of pulmonary hypertension as it relates to left ventricular heart failure. What are the diagnostic pitfalls, and current therapeutic options?"
  June 2016 ,Current Opinion in Nephrology and Hypertension,New Strategies to Tackle Diabetic Kidney Disease,Find out about the new therapeutic options for diabetic kidney disease. What is working and which new treatments are on the horizon?
  May 2016 ,American Journal of Public Health,Weight Loss Programs in People With Prediabetes,Can programs such as Weight Watchers reduce weight among persons with prediabetes as effectively as an individual counseling program?
  May 2016 ,Current Opinion in Psychiatry,How Precise Is Precision Medicine for Schizophrenia?,"While precision medicine has made great strides in other fields, such as oncology, its viability depends on identifying consistent biomarkers. Where do we stand on feasible targets in schizophrenia?"
  May 2016 ,Oncology Nursing Forum,Precision Medicine and Research Ethics,"Precision medicine is improving through genetics and genomics research, but also raises new ethical challenges."
  May 2016 ,BMC Gastroenterology,Light Alcohol Consumption: Predictor of Fatty Liver in MetS,New research studies whether minimal alcohol intake is protective against fatty liver in women with metabolic syndrome.
  May 2016 ,Arthritis Research & Therapy,Tapering and Discontinuation of TNF-a Blockers in RA,Can clinical and ultrasound-based remission be used to select patients with rheumatoid arthritis eligible to taper and discontinue TNF-a blockers?
  May 2016 ,Critical Care,Diagnosing Sepsis Is Subjective and Highly Variable,What accounts for the variability in the diagnosis of severe sepsis -- and what approaches may help improve consistency?
  May 2016 ,Alimentary Pharmacology & Therapeutics,"PPIs, Elimination Diet, and/or Budesonide for EoE","Do patients with eosinophilic esophagitis sustain remission from disease with PPIs, an elimination diet, and/or budesonide?"
  May 2016 ,Journal of Glaucoma,IOP in the Fellow Eye After Glaucoma Surgery in One Eye,How is intraocular pressure in the untreated fellow eye impacted after glaucoma surgery?
  May 2016 ,Journal of the American Geriatrics Society,Use of Antimuscarinic Medications in Individuals With OAB,How prevalent is potentially inappropriate use of anticholinergic OAB medications? What impact does inappropriate use have on healthcare costs for older adults?
  May 2016 ,BMC Family Practice,Communicating Statin Evidence to Support Shared Decisions,"This essay highlights the principles of evidence-informed shared decision-making in the context of statin guidelines, but is widely applicable to other clinical decisions."
  May 2016 ,Schizophrenia Bulletin,Yoga vs Standard Care for Schizophrenia,Is yoga effective in the treatment of schizophrenia?
  May 2016 ,BMC Clinical Pathology,Placental Morphology May Identify Specific Stillbirth Causes,"Can quantitative analysis of different aspects of placental structure, such as syncytial nuclear aggregates, proliferative cells, and blood vessels, help determine causes of stillbirth?"
  July 2016 ,The Journal of Invasive Cardiology,Describing Activity in Primary PCI,"The authors demonstrate the validity of the HEAT-SEALED pathway, an algorithm which offers a practical and comprehensive solution to the problem of describing denominators in STEMI and PPCI."
  July 2016 ,Journal of the National Cancer Institute,Immunotherapy Combined or Sequenced With Targeted Therapy,The newer immune checkpoint inhibitors are increasing treatment strategies for melanoma. Are they also increasing long-term survival?
  July 2016 ,European Heart Journal,Intestinal Congestion and Right Ventricular Dysfunction,What might be the mechanisms that contribute to cachexia in heart failure? This study investigates the potential involvement of intestinal congestion.
  July 2016 ,Clinical Gastroenterology and Hepatology,Defining Disease Severity in Inflammatory Bowel Diseases,"The authors propose three domains of criteria which could be used to develop a validated severity index for inflammatory bowel disease: impact, inflammatory burden, and disease course."
  July 2016 ,Brain,Emerging Therapies for Mitochondrial Disorders,"Several new approaches are currently under investigation for the treatment of mitochondrial diseases, on both the molecular and cellular level. Which hold the most promise?"
  July 2016 ,Liver International,Generic Medications for Hepatitis C,"While recent developments in direct-acting antiviral agents have proven a game-changer for treating hepatitis C, their high cost remains a barrier for many. Can--and should--generics take their place?"
  July 2016 ,Current Opinion in Infectious Diseases,Bordetella Pertussis: Concepts in Pathogenesis and Treatment,This review offers new insight into the pathogenesis of this infectious disease and discusses new and current treatment options.
  July 2016 ,Breast Cancer Research,Eliminating Breast Cancer Surgery in Exceptional Responders,Is surgery redundant in breast cancer patients who had a complete response to neoadjuvant chemotherapy?
  July 2016 ,European Heart Journal,Novel Mechanisms in the Pathogenesis of Atrial Fibrillation,This review focuses on a variety of novel mechanisms in the pathogenesis of AF. What therapeutic options are currently available and on the horizon which target these mechanisms?
  July 2016 ,Journal of the American College of Cardiology,Recent Endovascular Stroke RCTs: Their Impact on Stroke Care,"There have been five recently published RCTs of endovascular therapy versus medical management in the treatment of acute stroke, with positive findings. How will they transform stroke care?"
  July 2016 ,American Journal of Cardiovascular Drugs,Options for Reversing the Effect of Oral Anticoagulant Drugs,"The absence of a reversal agent for the direct oral coagulants has been a barrier to their wider use, but three new reversal agents are either under development or have been recently approved."
  July 2016 ,Journal of Perinatology : Official Journal of the California Perinatal Association,HRF and Pulmonary Hypertension in the Neonate,This review explores the challenges to developing effective therapies and discusses future research priorities in the field of neonatal hypoxemic respiratory failure and pulmonary hypertension.
  July 2016 ,Clinical Endocrinology,Adrenoceptor Blockade for Hormonally Functional Pheo/PGL,A new study examines whether patients with hormonally functional pheochromocytomas and paragangliomas (pheo/PGLs) are receiving the appropriate pharmacological treatment.
  July 2016 ,Arthritis Research & Therapy,Correlation of VAS Pain Scores After Treatment in RA and OA,Changes from baseline in VAS pain scores may predict response to NSAID treatment in patients with RA and OA.
  July 2016 ,Modern Pathology,miR-211 Detection as an Ancillary Test in Melanoma Diagnosis,The results of this study suggest that the detection of miR-211 expression by miRNA in situ hybridization could be a valuable aid in the diagnosis of melanoma.
  July 2016 ,Current Opinion in Rheumatology,New Therapies for Psoriasis and Psoriatic Arthritis,Read about the new therapies that are now available for patients with psoriatic disease.
  July 2016 ,Plastic and Reconstructive Surgery,Bacterial Biofilm in Breast Implant-Associated ALCL,What role does bacterial biofilm play in breast implant-associated anaplastic large-cell lymphoma?
  July 2016 ,Journal of the American Geriatrics Society,"Drug Utilization, Inappropriate Prescribing in Centenarians",Are centenarians being inappropriately medicated? This study utilized EHR data to explore the epidemiology of drug prescribing in persons over 100 years of age.
  June 2016 ,Emerging Infectious Diseases,"Astrovirus MLB2, a New Gastroenteric Virus",Find out the role next-generation sequencing played in identifying these cases of astrovirus MLB2 infection.
  June 2016 ,European Heart Journal,Mobile Technology and the Digitization of Healthcare,Which digital devices are helping to solve clinical problems? How will patients use and engage with these devices? These and other questions on the future of mHealth are addressed in this article.
  July 2016 ,Endocrine Practice,Treatment Intensification With Insulin Degludec/Aspart,How do these treatment intensification algorithms with insulin degludec/insulin aspart compare in terms of safety and efficacy?
  July 2016 ,The American Journal of Gastroenterology,Vitamin D and Risk of Non-alcoholic Steatohepatitis in NAFLD,Is vitamin D deficiency associated with non-alcoholic fatty liver disease? This study explores the molecular pathways that contribute to the relationship of vitamin D and NAFLD.
  July 2016 ,Liver International,Probiotics Are Helpful in Hepatic Encephalopathy,This study evaluates the efficacy of probiotics in the management of both minimal and overt hepatic encephalopathy. How did probiotics fare in comparison to no treatment or placebo?
  July 2016 ,Emerging Infectious Diseases,Leveraging Advances in Tuberculosis to Address NTM Disease,Could recent advances in the diagnosis and treatment of tuberculosis also provide new options for nontuberculous mycobacteria-associated disease?
  July 2016 ,Clinical Journal of Oncology Nursing,Applying the Chronic Care Model to Ostomy Self-Management,A nurse-led ostomy self-management program can play an important role in supporting these patients and helping them adjust to daily care requirements.
  July 2016 ,Translational Lung Cancer Research,Alectinib -- New Management for ALK-positive Lung Cancer,Is this next generation ALK inhibitor a good option for patients resistant to crizotinib?
  July 2016 ,European Heart Journal,Inflammatory Cytokines in Atherosclerosis,"This review explores the role of inflammatory cytokines in atherosclerosis, and the emerging role of cytokine-targeted treatment."
  July 2016 ,American Journal of Pharmaceutical Education,What Is an Acceptable Advanced Pharmacy Practice Experience?,Are today's pharmacy graduates achieving an adequate level of proficiency for entering into practice?
  July 2016 ,Spine,Biacuplasty vs Conventional Management for Lumbar Back Pain,Is one of these treatment methods for lumbar discogenic pain more effective than the other?
  July 2016 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Switching From EFV/FTC/TDF to EVG/COBI/FTC/TDF,How are the pharmacokinetics influenced after the regimen switch?
  July 2016 ,AIDS,Oral HPV in HIV Patients Is Not Reduced by Initiating ART,"ART initiation did not decrease the incidence of oral HPV infection among treatment-naive HIV patients, a new study reports."
  July 2016 ,Journal of Perinatology : Official Journal of the California Perinatal Association,Live Neonates Born to Mothers With Ebola Virus Disease,This review provides insight into the outcomes of live neonates born to pregnant women with Ebola virus disease.
  July 2016 ,American Heart Journal,Upper Normal Values of BP Response to Exercise in Athletes,"What are the normal values and upper limits of blood pressure in response to exercise in healthy, elite athletes?"
  July 2016 ,Alimentary Pharmacology & Therapeutics,Long-term Safety of Nucleotide Analogues in HBV Infection,What's the current data on long-term safety of entecavir and tenofovir disoproxil fumarate in the treatment of chronic HBV infection?
  July 2016 ,Journal of the American Geriatrics Society,Antipsychotic Drugs and Risk of Hip Fracture in Older Adults,Might the use of antipsychotic drugs contribute to hip fractures in older adults? This study looked at different classes of antipsychotics to assess the risk.
  July 2016 ,Journal of Viral Hepatitis,Care for Mothers With Chronic HBV Diagnosed During Pregnancy,"Screening of pregnant women for HBsAg is now routine, and ensures postexposure prophylaxis for the newborn. But are these HBV-infected mothers receiving adequate follow-up care?"
  July 2016 ,European Heart Journal,Drug-coated Balloon for Lower Extremity Vascular Disease,This position paper presents evidence-based recommendations for the use of drug-coated balloon technology in peripheral artery disease management.
  July 2016 ,American Journal of Epidemiology,Statins and Risk of Bleeding: Evaluating Possible Bias,"Statins have been associated with protection against bleeding risk during treatment with vitamin K antagonists, but might those results--and other study outcomes showing incidental benefit--be biased?"
  July 2016 ,Southern Medical Journal,Cardiovascular Health Status in Baby Boomers With T2DM,Are baby boomers with T2DM faring worse in terms of obesity and cardiovascular health than their counterparts in the previous generation?
  July 2016 ,American Journal of Public Health,Lower Sodium Intake and Risk of Headaches in the Elderly,Headaches have been associated with elevated blood pressure--as have high sodium diets. Can lowering sodium intake lead to a reduction in headaches in older persons with hypertension?
  August 2016 ,Clinical Endocrinology,Oral Carnitine Supplementation in Women With PCOS,The metabolic impacts of carnitine supplements in women with PCOS is examined in this study.
  August 2016 ,American Journal of Cardiovascular Drugs,Omega-3 Fatty Acid Formulations in Cardiovascular Disease,"This article points out the crucial differences in pharmacological properties between prescription and non-prescription omega-3 fatty acid products, highlighting the appropriate uses of each."
  August 2016 ,Journal of the National Cancer Institute,CARs Modified T-Cells for Cancer Therapy,"CAR T-cell cancer therapy is emerging and exciting. However, issues in safety, efficacy, and therapeutic potential require investigation."
  August 2016 ,Headache,Management of Adults With Acute Migraine in the ED,New guidelines provide evidence-based treatment recommendations on first-line injectable therapies for adults who present to the emergency department with acute migraine.
  August 2016 ,Clinical Endocrinology,Management of Primary Hypothyroidism,This position statement by the British Thyroid Association offers guidance on the management of primary hypothyroidism.
  August 2016 ,Current Opinion in Ophthalmology,An Update on New Low Add Multifocal Intraocular Lenses,Get up-to-date on the latest developments regarding low-add multifocal intraocular lenses for the correction of presbyopia.
  August 2016 ,Spine,Medical Device Innovation in the United States,"The United States has traditionally been on the cutting-edge of medical technology, but recent innovations in the medical device field have stagnated. What is the solution?"
  August 2016 ,Emerging Infectious Diseases,Debate Regarding Oseltamivir Use for Influenza,How effective is oseltamivir against seasonal and pandemic influenza? The debate over the appropriate use of the antiviral drug continues.
  August 2016 ,Gastroenterology,MRI Accurately Classifies Steatosis and Fibrosis in NAFLD,Which methods work best for grading hepatic steatosis and fibrosis?
  August 2016 ,Annals of Family Medicine,"Inadequate Hydration, BMI, and Obesity Among US Adults",Should we be focusing more on water intake in weight management research and clinical weight reduction strategies?
  August 2016 ,Endocrine Practice,Metformin-Sustained Weight Loss and Reduced Fat Tissue,Metformin combined with the EMPOWIR dietary intervention may help improve weight loss and reduce android fat in women with midlife weight gain.
  August 2016 ,Journal of the American College of Cardiology,"The Genesis, Maturation, Future of Critical Care Cardiology",Learn more about the evolution of critical care cardiology. What does the future hold for this rapidly evolving field?
  August 2016 ,Plastic and Reconstructive Surgery,Diep vs Pedicled Tram Flap Outcomes After Breast Surgery,How do these two techniques for reconstructive breast surgery compare in terms of complications and outcomes?
  August 2016 ,Journal of Cardiovascular Electrophysiology,Device Longevity in ICD/CRT-D Patients,What factors might be associated with the need to replace ICD devices? Does device longevity differ among manufacturers?
  July 2016 ,Alimentary Pharmacology & Therapeutics,Soluble/insoluble Fibre vs. Psyllium for Chronic Constipation,"Fiber supplements are useful in the treatment of chronic constipation, but which type is most effective, and best tolerated?"
  July 2016 ,Pediatric Nursing,Effects of Vibration Therapy in Pediatric Immunizations,Could vibration therapy effectively help ease immunization pain in children?
  July 2016 ,Annals of Surgery,10-Year Outcomes After Roux-en-Y Gastric Bypass,How do patients fare after undergoing Roux-en-Y gastric bypass surgery in terms of long-term weight loss and comorbidity reduction?
  July 2016 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,HIV Drug Resistance in Adults Failing Early ART,Does ART failure after the early initiation of treatment increase the risk of HIV drug resistance?
  July 2016 ,AIDS,Nelfinavir and Cancer Incidence in HIV-Positive Individuals,This study examined the rates of cancer among HIV positive patients exposed to nelfinavir.
  July 2016 ,Gastroenterology,Rectal Indomethacin Does Not Prevent Post-ERCP Pancreatitis,New research finds that prophylactic rectal indomethacin does not reduce incidence of post-ERCP pancreatitis. Should published guidelines be reconsidered?
  August 2016 ,Current Opinion in Neurology,Atypical Parkinsonism -- New Advances,The author reviews the most recent advances in our understanding of the genetics and pathophysiology of atypical parkinsonism. Are we getting closer to a neuroprotective treatment?
  August 2016 ,Headache,Treatment of Cluster Headache: AHS Evidence-Based Guidelines,New evidence-based guidelines from the American Headache Society provide recommendations for the abortive and preventive treatment of cluster headache.
  August 2016 ,Current Opinion in Pulmonary Medicine,"Lung Cancer in COPD, It Is Not Just the Cigarette Smoke","The development of lung cancer in patients with COPD has been linked with tobacco exposure, but other factors may also play a role."
  August 2016 ,Pediatric Critical Care Medicine,Procalcitonin in Early Post Pediatric Cardiac Surgery,What can postoperative procalcitonin levels tell us about outcomes after cardiac surgery in children?
  August 2016 ,Critical Care Medicine,Long-term Quality of Life Among Survivors of Severe Sepsis,How does sepsis impact quality of life? New research looks into how patients who survived severe sepsis fared in the long-term.
  August 2016 ,Clinical Endocrinology,Treatment Options in the Young Patient With Graves' Disease,"In this review, the advantages and disadvantages of available treatment options for young patients with Graves disease are discussed."
  August 2016 ,Journal of Clinical Rheumatology,Cancers and Infections in Patients With and Without PSA,Are the rates of cancers and opportunistic infections higher among patients with psoriatic arthritis -- compared with those without the condition?
  August 2016 ,American Journal of Clinical Dermatology,Chronic Pruritus in the Absence of Skin Disease,"Chronic pruritis in the absence of skin disease can be distressing to the patient, challenging to diagnose, and equally challenging to treat. What's the best approach to diagnosis and management?"
  August 2016 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,PrEP Adherence Affects Efficacy and Individual HIV Risk,Find out how the efficacy of PrEP protection against HIV infection is impacted by patterns of adherence.
  August 2016 ,AIDS,Virologic Failure After Treatment Initiation in Acute HIV,What do we know about viral dynamics after the initiation of antiretroviral therapy during acute HIV infection?
  August 2016 ,The American Journal of Gastroenterology,Chronic HCV: Patient-Reported Outcomes With Anti-Virals,Which anti-viral regimens had the least negative impact on self-reported outcomes and quality of life in patients with chronic hepatitis C?
  August 2016 ,Liver International,Entecavir/Tenofovir Therapy in Drug Resistant Chronic HBV,This study evaluated the antiviral efficacy and safety of entecavir plus tenofovir combination therapy in multidrug-resistant chronic hepatitis B patients.
  August 2016 ,Seminars in Respiratory and Critical Care Medicine,"Recent Advances, Future Needs in Interstitial Lung Diseases",Learn about the progress that has been made in the understanding and management of interstitial lung diseases -- and the challenges that remain.
  August 2016 ,Wounds,Combination Artificial Dermis and Basic FGF for Skin Defects,What are the effects of this combined therapy on skin defects?
  August 2016 ,BMC Anesthesiology,Cardiac Power Parameters During Hypovolemia,Might dynamic and non-dynamic cardiac power parameters track hypovolemia better than equivalent flow- and pressure parameters?
  August 2016 ,Journal of the American Geriatrics Society,Mainstream or Extinction: Saving Geriatrics,Is there a future for geriatrics? This commentary examines what's wrong with current strategies and suggests changes to increase the survival of geriatrics as a specialty.
  August 2016 ,Journal of Viral Hepatitis,GS-9190: Antiviral Response in Treatment-Naive HCV,This phase 1b study of the investigational drug GS-9190 monitored its resistance profile when used as monotherapy in treatment-naive HCV-infected patients.
  August 2016 ,BMC Pulmonary Medicine,Concurrent Treatments in IPF With Respiratory Failure,What benefits could combined treatments offer IPF patients with a rapid progression of respiratory failure?
  August 2016 ,Critical Care,Antibiotic Strategies in the Era of Multidrug Resistance,These strategies for the appropriate antibiotic management of ICU patients will help prevent further development of drug resistance.
  August 2016 ,Annals of Surgery,Inflammatory and Immune Responses to Surgery,Gain a better understanding of the postoperative inflammatory and immune responses in surgical patients and find out how they may impact clinical outcomes.
  September 2016 ,Annals of Surgery,Oral and Parenteral Prophylaxis in Colorectal Surgery,"When it comes to administering prophylactic antibiotics for laparoscopic colorectal surgery, what is the optimal regimen?"
  August 2016 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,RPV and DOR Efficacies Against NNRTI-Resistant HIV-1 Mutants,Find out how these two non-nucleoside reverse transcriptase inhibitors compare in the combat against NNRTI-resistant mutations.
  August 2016 ,American Journal of Transplantation,Induction Immunosuppression in Kidney Transplants With HIV,Should induction immunosuppression therapy be considered for HIV-positive kidney transplant recipients?
  August 2016 ,Neurosurgical Focus,The Science and Questions Surrounding CTE,Does the presence of cerebral tau protein equal a diagnosis of CTE? Is CTE a progressive disorder? These and other common questions regarding CTE are addressed in this article.
  August 2016 ,Preventing Chronic Disease,Prevalence of Diabetes in Patients From Safety Net Clinics,"Is overall prevalence of diabetes being underestimated by not including underserved and underrepresented individuals, such as those that attend safety net clinics, in diabetes registries?"
  August 2016 ,American Heart Journal,Effects of Interactive Patient Smartphone Support App in MI,Can a smartphone-based interactive patient support tool improve treatment adherence and cardiovascular lifestyle in MI patients?
  August 2016 ,Alimentary Pharmacology & Therapeutics,Novel Therapies for Hepatitis B Virus Cure,Will hepatitis B be eradicated in the near future? What are the major barriers to cure?
  August 2016 ,Journal of Viral Hepatitis,Predicting Work Productivity in Patients Infected With HCV,Can specific pre-treatment clinical and patient-reported factors predict work productivity impairment in HCV-infected patients?
  August 2016 ,Pediatric Critical Care Medicine,ECMO for Cardiac Indications in Children,What do we currently know about the use of extracorporeal membrane oxygenation in children with heart disease?
  August 2016 ,Current Opinion in Allergy and Clinical Immunology,Biologic Therapy in the Management of Asthma,What benefit does biologic therapy offer patients with asthma? A new review examines the current role of these agents in managing this disease.
  August 2016 ,Medicine and Science in Sports and Exercise,Exercise for ADHD and Disruptive Behavior Disorders,What benefits could regular physical activity offer children with ADHD and disruptive behavior disorders?
  August 2016 ,Seminars in Neurology,Critical Care Management of Intracerebral Hemorrhage,"The authors discuss the neurocritical care management of intracerebral hemorrhage based on current evidence and guidelines, highlighting prevention and management of medical complications."
  August 2016 ,Critical Care,Ebola Virus Disease and Critical Illness,Find out what there is to know regarding the critical care management of Ebola-infected patients.
  August 2016 ,BMC Pulmonary Medicine,Blood Eosinophil Markers to Predict Severity of Asthma,Are measuring blood eosinophil levels an effective way to determine disease severity in asthma?
  August 2016 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Interaction Between EE2/DSG and LPV/r in HIV+ Adolescents,Could oral contraceptives containing ethinyl estradiol/desogestrel compromise the effectiveness of lopinavir/ritonavir-based therapy?
  August 2016 ,Journal of the National Cancer Institute,Colon Cancer With Microsatellite Instability: Adjuvant Chemo,Is deficient mismatch repair colon cancer resistant to adjuvant 5-fluorouracil plus oxaliplatin?
  August 2016 ,AIDS,Effectiveness and Safety of Oral HIV Preexposure Prophylaxis,Is preexposure prophylaxis a safe and effective preventive strategy against HIV infection?
  August 2016 ,Neurosurgical Focus,Sports-related TBI: Connecting Pathology to Diagnosis,"A better understanding of the pathology and molecular changes associated with sports-related head trauma may lead to innovations in imaging techniques and new biomarkers, according to this article."
  August 2016 ,Pediatric Critical Care Medicine,Burden and Outcomes of Severe Pertussis Infection in Infants,A new study explores the incidence and outcomes of infants requiring intensive care due to severe disease caused by pertussis infection.
  August 2016 ,Arthritis Research & Therapy,Biomarkers Related to Disease Activity in Sjogren's Syndrome,The authors have identified serum biomarkers that may play a key role in evaluating disease activity in primary Sjogren's syndrome.
  September 2016 ,Rheumatology,Prevention of Autoantibody-Positive Rheumatoid Arthritis,A new review looks at the potential risk factors that may contribute to the development of rheumatoid arthritis and discusses preventive strategies.
  September 2016 ,Nephrology Dialysis Transplantation,Controlling Phosphorus in Chronic Kidney Disease,"Controlling serum phosphorus in chronic kidney disease has proved challenging, but doing so improves clinical outcomes among these patients."
  September 2016 ,American Journal of Epidemiology,Androgen Deprivation and Incidence of IBS in Prostate Cancer,Might sex hormones play a role in the etiology of IBS? This study examines the potential link between androgen deprivation therapy and IBS incidence in patients with prostate cancer.
  September 2016 ,Headache,Zolmitriptan Nasal Spray for Acute Migraine in Adolescents,Is zolmitriptan nasal spray more effective than placebo in the acute treatment of migraine headache in patients 12-17 years of age?
  September 2016 ,Age and Ageing,Treatment With SSRIs vs. Placebo for Progression of Dementia,Do SSRIs fare better than placebo for improving cognitive performance in people with dementia? This meta-analysis examines the current evidence.
  September 2016 ,American Journal of Cardiovascular Drugs,Ivabradine: A Review of Labeled and Off-Label Uses,"Due to its unique mechanism of action, ivabradine, recently approved in the US for certain heart failure patients, has several potential off-label uses. Review its many indications in this article."
  September 2016 ,The British Journal of Dermatology,Use of the Itch Numeric Rating Scale in Psoriasis,"The authors evaluate the reliability, validity and responsiveness of a new tool to rate itching severity in psoriasis, the Itch Numeric Rating Scale."
  September 2016 ,American Journal of Transplantation,Economic Impacts of ABO-Incompatible Kidney Transplantation,ABO-incompatible kidney transplantation is a costly undertaking. What are the economic impacts of performing this procedure?
  September 2016 ,Current Opinion in Rheumatology,Pathophysiology and Treatment of Human Lupus Nephritis,Gain a better understanding of the pathophysiology of lupus nephritis and learn about the best therapeutic strategies for this disease.
  September 2016 ,Alimentary Pharmacology & Therapeutics,Comparative Effectiveness of HCV Combination Therapies,This analysis compared the efficacy of two commonly used regimens of oral antiviral therapy in a cohort of veterans with hepatitis C.
  September 2016 ,Journal of Viral Hepatitis,HCV Treatment Failure and Risk of Hepatocellular Carcinoma,Are patients with hepatitis C who receive antiviral treatment but fail to achieve sustained virological response more likely to develop hepatocellular carcinoma than untreated patients?
  September 2016 ,Annals of Surgery,Minimally Invasive vs Open Low Anterior Resection,How do these two techniques for low anterior resection for rectal cancer compare in terms of survival outcomes?
  September 2016 ,Critical Care,Mechanical Ventilation for ICU Patients Without ALI or ARDS,Learn about the ventilation strategies that may help prevent complications and improve outcomes among critically ill patients without acute lung injury or ARDS.
  September 2016 ,Europace,Anticoagulation Reversal With NOACs,"This article reviews the pharmacology of the non-vitamin K oral anticoagulants, and explores the currently available options for reversal of their anticoagulant effects."
  September 2016 ,HIV Medicine,Weight Gain After ART and Risk of CVD and Diabetes,Is weight gain after ART initiation associated with an increased risk of developing cardiovascular disease and diabetes?
  September 2016 ,Emerging Infectious Diseases,Development of Medical Countermeasures to MERS Coronavirus,What progress has been made in the development of effective medical countermeasure strategies against MERS-CoV?
  September 2016 ,Arthritis Research & Therapy,Patient vs Physician Assessments of Disease Activity in RA,RA disease activity assessments may differ between patients and physicians. How does this discordance impact a patient's ability to work?
  September 2016 ,Journal of the American College of Cardiology,Bioabsorbable Intracoronary Matrix for LV Remodeling After MI,"This study investigated whether intracoronary injection of a novel alginate, bioabsorbable cardiac matrix, might attenuate adverse LV remodeling after large myocardial infarctions."
  September 2016 ,The British Journal of Dermatology,Cut-off Values in ABSIS and PDAI Pemphigus Scoring Systems,"The authors propose cut-off values which can be used to define moderate, significant and extensive pemphigus based on two new scoring systems intended to quantify the extent of disease."
  September 2016 ,American Journal of Pharmaceutical Education,Successfully Producing and Publishing Educational Research,Do your manuscript submissions contain flaws? Increase your submission success rate with these tips.
  September 2016 ,Alimentary Pharmacology & Therapeutics,Prognostic Significance of Fecal Calprotectin in Inactive IBD,Could consecutive measurements of fecal calprotectin every third month predict relapse in patients with IBD who are currently in clinical remission?
  September 2016 ,Journal of Viral Hepatitis,Epidemiology and Outcomes of HCV Infection in Elderly US Vets,"Patients with hepatitis C infection are getting older in the United States, yet are underrepresented in clinical trials. How does age impact outcomes with and without antiviral treatment?"
  September 2016 ,Annals of Oncology,Systematic Evaluation of Pembrolizumab Dosing in NSCLC,Which dose of pembrolizumab is optimal for advanced NSCLC? Is higher better?
  September 2016 ,AIDS,Rosuvastatin Slows Progression of Atherosclerosis in HIV,Find out what there is to know about the effect of rosuvastatin on subclinical atherosclerosis among HIV-infected individuals receiving antiretroviral therapy.
  September 2016 ,The Journal of Emergency Medicine,Red Blood Cell Transfusion in the Emergency Department,Find out what emergency physicians need to know regarding the transfusion of red blood cells for the treatment of anemia.
  September 2016 ,Southern Medical Journal,Features of Respiratory Viral Infections Among Inpatients,"What are the clinical signs and symptoms of respiratory viral infections among hospital inpatients, and how might they differ from those of bacterial infections?"
  September 2016 ,Journal of the American College of Cardiology,Outcomes of Patients With Atrial Fibrillation Undergoing PCI,Is a history of atrial fibrillation an independent risk factor for poor clinical outcomes after PCI?
  September 2016 ,HIV Medicine,Efficacy of Protease Inhibitor Monotherapy vs Triple Therapy,"In patients with HIV-1 RNA suppression, which of these treatment regimens is the better choice?"
  September 2016 ,European Heart Journal,Troponin and Coronary CTA in the Evaluation of Suspected ACS,"This review evaluates the potential roles of high sensitivity troponin and coronary CTA, separately as well as in combination, for the evaluation of patients presenting with suspected ACS in the ED."
  September 2016 ,BMC Pulmonary Medicine,Mechanical Ventilation for ARF in Immunocompromised Patients,Which is the better option when it comes to mechanical ventilation for acute respiratory failure in patients with immunocompromised conditions?
  September 2016 ,Schizophrenia Bulletin,Universal Health Coverage for Schizophrenia,The author makes the case for the inclusion of care for people with schizophrenia in the basic package of services covered by universal health coverage.
  September 2016 ,Annals of Oncology,Frequent PD-L1 Expression in Penile Squamous Cell Carcinoma,Are checkpoint inhibitors a new option for penile squamous cell carcinoma?
  September 2016 ,Menopause,Hot Flashes: Emerging Cardiovascular Risk Factors,"This study examined the association of hot flashes with endothelial dysfunction, hypertension, and other markers of cardiovascular disease. Could severe hot flashes be an indicator of CVD risk?"
  September 2016 ,HIV Medicine,Improvement of Lipoatrophy by Switching From EFV to LPV/r,Switching HIV patients with lipoatrophy from efavirenz to lopinavir/ritonavir may affect positive changes in limb fat.
  September 2016 ,American Journal of Epidemiology,Risk of Preterm Birth After Influenza Vaccine During Pregnancy,Are observational studies evaluating the effect of maternal influenza immunization on fetal health prone to bias?
  September 2016 ,Current Opinion in Nephrology and Hypertension,Understanding Renal Ammonia Metabolism and Transport,Recent advances have provided new insights into the renal process of ammonia metabolism and transport.
  September 2016 ,The British Journal of Dermatology,Brodalumab in Moderate-to-Severe Plaque Psoriasis,"A novel human anti-interleukin-17 receptor antibody, brodalumab, shows great promise in treating patients with moderate-to-severe plaque psoriasis."
  September 2016 ,Journal of the American Geriatrics Society,Syncope and Unexplained Falls in Elderly Adults With Dementia,"The authors present a simplified, standardized diagnostic protocol for determining the etiology of suspected syncope and unexplained falls in elderly adults with dementia."
  September 2016 ,Liver International,Incidence of HCC in Untreated Subjects With Chronic HBV,"What factors influence the incidence of hepatocellular carcinoma in patients with untreated, chronic hepatitis B infection?"
  September 2016 ,European Heart Journal,Outcomes of Patients With Hypothyroidism Undergoing PCI,Are patients with a history of hypothyroidism at increased risk of major adverse cardiovascular and cerebral events following PCI?
  October 2016 ,Menopause,Anxiety As a Risk Factor for Menopausal Hot Flashes,This study examined the predictive value of somatic anxiety as an independent risk factor for menopausal hot flashes. Might anxiety be a potential target for treatment?
  October 2016 ,Rheumatology,Anti-TNF Discontinuation and Tapering in Axial SpA,A new study examines the efficacy of discontinuation and tapering strategies of anti-TNF therapy in patients with axial spondyloarthritis.
  October 2016 ,Clinical Gastroenterology and Hepatology,"Diet, Drugs, and Gastric Interventions for Gastroparesis","The pathophysiology of gastroparesis is elucidated in this review, which highlights new treatment approaches, including diet, novel drugs, pyloric interventions, and gastric electrical stimulation."
  October 2016 ,Preventing Chronic Disease,Racial/Ethnic Disparities in Care Among T2DM Patients,Are minority patients with type 2 diabetes receiving equitable primary care?
  October 2016 ,Plastic and Reconstructive Surgery,Is Single-Stage Prosthetic Reconstruction Cost Effective?,A new analysis compares the costs and clinical outcomes between single-stage versus the two-stage technique for prosthetic breast reconstruction. How do they measure up?
  September 2016 ,Alimentary Pharmacology & Therapeutics,Steroid Dependency and Trends in Prescribing for IBD,Therapeutic guidelines for inflammatory bowel disease have evolved significantly over the last 20 years. Are clinicians adhering to current prescribing standards?
  September 2016 ,Annals of Oncology,Immune Escape to PD-L1/PD-1 Blockade: Seven Steps,Why do only some patients have durable responses with PD-L1/PD-1 targeted therapy? Understanding these 7 steps of immune escape will help us provide more effective personalized cancer immunotherapy.
  September 2016 ,Current Opinion in Psychiatry,Treatment for Complicated Grief: State of the Science,"This review explores the controversies with regard to establishing complicated grief as a psychiatric disorder. What works best to treat disabling grief, and which patients may benefit?"
  September 2016 ,American Journal of Epidemiology,Circulating Prolactin and Risk of Type 2 Diabetes,Might prolactin be a mediator in the pathogenesis of type 2 diabetes?
  September 2016 ,European Heart Journal,Antithrombotic Therapy in HF Patients With and Without AF,"Atrial fibrillation and heart failure often coexist, presenting a high-risk situation. This review explores approaches to antithrombotic treatment in these patients, focusing on novel anticoagulants."
  September 2016 ,Nephrology Dialysis Transplantation,Effect of Renal Impairment on Atherosclerosis,Total homocysteine levels may contribute to the effect of renal impairment on atherosclerosis. What other factors may be involved?
  September 2016 ,American Heart Journal,Concomitant Aspirin in Patients With Atrial Fibrillation,Is aspirin safe to use in conjunction with rivaroxaban or warfarin therapy in patients with atrial fibrillation?
  September 2016 ,Schizophrenia Bulletin,Engaging Research Domain Criteria,This article discusses how a clinical investigator can engage RDoC methodology to explore the neurobiological underpinnings of psychopathology. How can research be formulated within RDoC's framework?
  September 2016 ,Annals of Oncology,Modified FOLFOX6 With or Without Aflibercept in mCRC,Does the addition of aflibercept to first-line mFOLFOX6 improve outcomes in mCRC?
  September 2016 ,HIV Medicine,Risk of Failure of ABC/3TC or TDF/FTC Based Regimens,How do these two HIV treatment regimens compare in terms of efficacy and the likelihood of failure among patients with high baseline viral loads?
  September 2016 ,Journal of the American College of Cardiology,Revascularization Options in Patients With T2DM and CAD,What is the optimal treatment approach to patients with type 2 diabetes and stable coronary artery disease?
  September 2016 ,Journal of Medical Case Reports,Vildagliptin-induced Acute Lung Injury: A Case Report,"DPP-4 inhibitors are generally well tolerated, but serious complications have been reported, as in this case of a patient who developed acute lung injury shortly after taking vildagliptin."
  September 2016 ,Current Opinion in Allergy and Clinical Immunology,Management of Rhinosinusitis: An Evidence Based Approach,Find out what the latest evidence tells us about current management strategies for acute and chronic rhinosinusitis.
  September 2016 ,The British Journal of Dermatology,Discontinuation of Biologic Therapy in Psoriasis,This study examined clinical characteristics that might predict the discontinuation of therapy in psoriasis patients using the three commonly prescribed biologic therapies.
  September 2016 ,Skin Therapy Letter,Frontal Fibrosing Alopecia,Why are clinicians seeing an apparent increase in the incidence of frontal fibrosing alopecia? Might there be environmental triggers for this clinical variant of lichen planopilaris?
  October 2016 ,AIDS,Standard Vaccines Increase HIV-1 Transcription During ART,A new study provides insight into the impact of standard clinical vaccinations on HIV transcription.
  October 2016 ,HIV Medicine,TDF/FTC and ABC/3TC Combined With EFV or ATV/r for HIV-1,The efficacy and cost-effectiveness of four antiretroviral regimens for treatment-naive adults with HIV-1 infection are examined here.
  October 2016 ,Alimentary Pharmacology & Therapeutics,Gut-to-Brain and Brain-to-Gut Pathways in IBS and Dyspepsia,This study examines the bidirectional relationship of the brain and the gut in IBS and other functional GI disorders.
  October 2016 ,Annals of Surgery,Outcomes of Robotic vs Open Pancreaticoduodenectomy,How do the perioperative outcomes compare between these approaches to pancreaticoduodenectomy?
  October 2016 ,European Heart Journal,AVR: Mechanical vs Biological Prostheses,Are bioprosthetic valves associated with better long-term survival and reduced risk of stroke after AVR than mechanical valves?
  October 2016 ,Current Opinion in Rheumatology,Update on Clinical Trials in Systemic Lupus Erythematosus,What can we learn from recent trials regarding the treatment options for systemic lupus erythematosus? Find out what's new.
  October 2016 ,Nephrology Dialysis Transplantation,Risk Factors for Incident PAD Among Patients With CKD,Certain non-traditional factors may contribute to the risk of developing peripheral arterial disease among chronic kidney disease patients. What are they?
  October 2016 ,Journal of the National Cancer Institute,PCa Diagnosis by MR/Ultrasound Fusion-Guided Biopsy,Which biopsy is more efficient in men with MR-visible prostate lesions? Targeted or standard?
  October 2016 ,Clinical Endocrinology,Immune Checkpoint Inhibitor-Related Hypophysitis,Find out what there is to know about hypophysitis and the endocrine side effects associated with the use of immune checkpoint inhibitors for the management of cancer.
  October 2016 ,Annals of Oncology,Crizotinib Resistance: Therapeutic Strategies,How can resistance to this ALK inhibitor be overcome? Find answers and potential therapeutic interventions with this review.
  October 2016 ,AIDS,Cost Considerations in the Current Antiretroviral Era,Antiretroviral therapy is an effective but costly treatment for HIV. Which regimens are the most cost-effective?
  October 2016 ,The Journal of Emergency Medicine,Trends in ED Visits by Adults With Mental Health Disorders,This study reports on the patterns of emergency department use among adults with mental health disorders in the U.S. What are the trends?
  October 2016 ,HIV Medicine,"HIV, Highly Active Antiretroviral Therapy and the Heart",What do we know about the cardiometabolic effects of HAART and the risk of cardiovascular disease among HIV-1 infected patients?
  October 2016 ,Alimentary Pharmacology & Therapeutics,Hydration in the Prevention of Post-ERCP Pancreatitis,Post-ERCP pancreatitis is the most frequent complication of ERCP. Is periprocedural hydration effective as a preventive measure?
  October 2016 ,Journal of Clinical Rheumatology,Role of Ultrasonography in Knee Osteoarthritis,What is the role of ultrasound in the detection and management of knee osteoarthritis?
  October 2016 ,Rheumatology,"Undertreatment of Hypertension, Hypercholesterolemia in RA",Hypertension and hypercholesterolemia are problems that are not as recognized or appropriately treated in RA patients as they should be.
  October 2016 ,Critical Care,Probiotic and Synbiotic Therapy in Critical Illness,Could probiotics and synbiotic therapy have a role in the management of critically ill patients? This review examines the possible beneficial effects.
  October 2016 ,European Heart Journal,Cell-based Therapies for Myocardial Repair in IHD and HF,This position paper provides recommendations on how to improve the therapeutic application and assess the clinical benefits of cell-based therapies for cardiac regeneration and repair.
  October 2016 ,Annals of Oncology,Palonosetron vs Granisetron for Preventing CINV,Is palonosetron better than granisetron for preventing CINV? A new study provides the answer.
  October 2016 ,HIV Medicine,A Study of DRV/r for HIV Post-Exposure Prophylaxis,Should ritonavir-boosted darunavir be considered as part of a HIV post-exposure prophylaxis regimen?
  October 2016 ,HIV Medicine,3TC and FTC Combined With TDF and a PI in HIV-1 Infection,How do these treatment regimens affect the virological responses in treatment-naive HIV-1-infected patients?
  October 2016 ,Current Opinion in Gastroenterology,Clinical Chronic Pancreatitis,"This review summarizes recent advances in our understanding of chronic pancreatitis, including new genetic findings, novel diagnostics, and emerging medical and surgical treatments."
  October 2016 ,HIV Medicine,Influenza Vaccination to HIV-Infected Patients,What is the optimal timing for administering influenza vaccines to HIV-infected individuals?
  October 2016 ,Skin Therapy Letter,Sodium Deoxycholate for Submental Contouring,"This article reviews the use of a first-in-class injectable therapy, deoxycholic acid, as a minimally invasive, office-based treatment for submental fullness, commonly known as ""double-chin."""
  October 2016 ,Journal of Viral Hepatitis,Grazoprevir + Ribavirin in Patients With HCV Genotype 1,This study evaluated the safety and efficacy of a regimen of grazoprevir plus ribavirin in patients with HCV GT1 infection. What's the optimal dose and duration of therapy?
  October 2016 ,Europace,Dabigatran vs. Acenocoumarol in Real-world Patients With AF,"While clinical trials have demonstrated the effectiveness and safety of dabigatran, how does it fare in daily clinical practice, compared to a vitamin K antagonist?"
  October 2016 ,HIV Medicine,Determinants of Residual Viremia During cART,Which factors are associated with residual viremia in patients on combination antiretroviral therapy?
  October 2016 ,The Journal of Invasive Cardiology,Heparin vs Bivalirudin in STEMI,Which is the preferred antithrombotic strategy for STEMI patients undergoing primary percutaneous coronary intervention? A survey of interventional cardiologists provides some insight.
  October 2016 ,Preventing Chronic Disease,Polypharmacy and HRQoL Among US Adults With Arthritis,Polypharmacy is common in adults with arthritis. What impact does this have on health-related quality of life?
  October 2016 ,Rheumatology,Factors Associated With Choice of Biologic for JIA,Which factors may influence the choice of biologics prescribed for juvenile idiopathic arthritis?
  October 2016 ,Clinical Gastroenterology and Hepatology,Mucosal Healing and Long-term Outcomes in Ulcerative Colitis,Should mucosal healing be targeted as a goal of therapy for ulcerative colitis?
  October 2016 ,Alimentary Pharmacology & Therapeutics,"Predictors of Response, Recurrence in C. difficile Infection",Could gut microbial signatures serve as predictive biomarkers for treatment response and recurrence in C. difficile infection?
  October 2016 ,Spine,Diabetes Impacts on Surgical Outcomes in Cervical Myelopathy,In what ways are the surgical outcomes of cervical spondylotic myelopathy impacted by diabetes?
  October 2016 ,Journal of the American Board of Family Medicine,Patients' Willingness to Participate in Weight Loss Programs,Understanding the factors associated with weight loss program participation among primary care patients could raise the number of those who are willing to join in.
  October 2016 ,Journal of the National Cancer Institute,Adjuvant Radiation and Chemotherapy in Merkel Cell Carcinoma,Does adjuvant radiotherapy improve overall survival in Merkel cell carcinoma?
  October 2016 ,HIV Medicine,Carotid Artery Thickness Associated With Chronic HAART Use,"HIV patients on chronic HAART showed increased carotid artery wall thickness compared with similar controls, an MRI study shows."
  October 2016 ,American Journal of Transplantation,Dynamic Kidney and Liver Preservation and Resuscitation,Discover what there is to know about dynamic preservation of kidney and liver grafts -- and find out what the future holds.
  October 2016 ,Clinical Endocrinology,Utility of Blood Markers in the Diagnosis of PNETs in MEN1,A new study explores the potential diagnostic value of these markers for diagnosing pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1 patients.
  October 2016 ,American Journal of Kidney Diseases,Lactic Acidosis: Current Treatments and Future Directions,This new article examines current strategies for the treatment of lactic acidosis and discusses the potential benefits of alternative therapies.
  October 2016 ,Annals of Oncology,The Continuum of Care for ALK-positive NSCLC,"Learn more about rearrangements in ALK, diagnostics for ALK-positive lung cancers, and ALK inhibitors here."
  November 2016 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,A Single-Tablet Regimen of E/C/F/TAF in HIV/HBV Coinfection,Is this regimen a safe and effective therapeutic option for treating HIV/HBV coinfection?
  November 2016 ,Alimentary Pharmacology & Therapeutics,Ombitasvir/Paritaprevir/Ritonavir Regimen for Hepatitis C,"This combination drug regimen proved highly effective for treatment of chronic HCV infection, even in difficult-to-treat populations and individuals with advanced disease."
  November 2016 ,Clinical Gastroenterology and Hepatology,Risks of Biological Therapies in Patients With IBD,"Novel biologics have proved effective for improving outcomes in inflammatory bowel disease, but do they increase the risk of developing opportunistic or serious infections and malignancies?"
  November 2016 ,Plastic and Reconstructive Surgery,Antibiotic Prophylaxis Following Breast Reconstruction,Evidence supporting the use of postoperative prophylactic antibiotics after prosthetic breast reconstruction is reviewed.
  November 2016 ,HIV Medicine,Statins and Incident Diabetes in HIV-1 Patients on cART,"The use of statins was not significantly associated with an increased risk of developing incident diabetes mellitus among HIV-1 patients, a new study reports."
  November 2016 ,Journal of the National Cancer Institute,"The Conundrum of Genetic ""Drivers"" in Benign Conditions",Genetic alterations such as HER2 and BRAF can be found in benign conditions. Are tumor suppressors preventing such driver mutations from promoting tumorigenesis?
  November 2016 ,Alimentary Pharmacology & Therapeutics,HCV Therapy in Elderly Patients and Drug-Drug Interactions,"Until the availability of direct antiviral therapies, treatment options in elderly patients with chronic HCV infection were limited. How safe and effective are these agents in patients over 65 years?"
  November 2016 ,Seminars in Respiratory and Critical Care Medicine,Antivirals for Respiratory Viral Infections,Recent years have seen the development of new antiviral agents for respiratory viruses. Where do we stand in finding effective treatment?
  November 2016 ,U.S. Pharmacist,Therapeutic Management of Autoimmune Hepatitis,How does treatment of autoimmune hepatitis differ from that of other etiologies? Learn about current and emerging therapeutic options in this review.
  October 2016 ,American Journal of Transplantation,Blood Transfusion After Kidney Transplantation and DSAs,How does post-transplant blood transfusion impact anti-HLA sensitization and donor-specific antibody development after kidney transplantation?
  October 2016 ,Cancer Control: Journal of the Moffitt Cancer Center,Therapeutic Options for Retinoblastoma,"Over the past decade, localized chemotherapy and targeted drugs have become therapeutic options for retinoblastoma."
  October 2016 ,AIDS,Treatment Interruption After ART During Early HIV in Infancy,"Could HIV-infected infants benefit from a short interruption of antiretroviral therapy, or is continued treatment the better option?"
  October 2016 ,American Heart Journal,Effects of Statins on Mild Noncalcified Coronary Plaque,Do statins slow progression of noncalcified plaque? Does statin intensity change plaque volume over time?
  October 2016 ,Alimentary Pharmacology & Therapeutics,DAAs in Non- and Post-liver Transplant Patients With HCV-1,This study evaluated the effectiveness and tolerability of simeprevir and sofosbuvir in non- and post-transplant HCV-1 infected patients with traditional risk factors for poor treatment response.
  October 2016 ,HIV Medicine,Rosuvastatin vs Protease Inhibitor for Hypercholesterolemia,Is rosuvastatin a safe and effective alternative to protease inhibitor switching for HIV-1 infected individuals with hypercholesterolemia?
  October 2016 ,Current Opinion in Allergy and Clinical Immunology,Allergy Prevention by Breastfeeding,Does breast milk offer protective benefits against the development of allergies? Find out what the evidence says.
  October 2016 ,Alimentary Pharmacology & Therapeutics,Adding Ribavirin to Newer DAA Regimens for HCV-1,Does the addition of ribavirin to regimens comprised of newer direct acting anti-viral agents improve sustained viral response rates in HCV-1 infected persons?
  October 2016 ,Journal for Nurse Practitioners,Direct Oral Anticoagulants: A Patient-Centered Review,Find out what there is to know about the new oral agents for anticoagulation as an alternative to warfarin.
  October 2016 ,Journal of the American Board of Family Medicine,Improving Primary Care Identification and Management of CKD,Could the use of clinical decision support tools help improve the detection and management of CKD in primary care?
  October 2016 ,Nephrology Dialysis Transplantation,Albuminuria Exposure in ARB Therapy Predicts Renal Outcome,A new study explores the prognostic value of individual albuminuria fluctuations after angiotensin receptor blocker initiation.
  December 2016 ,Translational Lung Cancer Research,Histopathological Transformation to SCLC in NSCLC Tumors,Is it time to re-biopsy? Deterioration during targeted therapy may indicate transformation of NSCLC to SCLC.
  December 2016 ,Wounds,Histogram Planimetry Method for Measuring Irregular Wounds,Histogram planimetry may offer an alternative option for measuring the area of irregularly shaped wounds.
  December 2016 ,BMC Anesthesiology,RCTs vs. Observational Studies: Why Not Just Live Together?,"While RCTs are generally regarded as the gold standard to evaluate the efficacy of an intervention, the authors of this commentary make a case for the value of observational studies as well."
  November 2016 ,Endocrine Practice,"AACE, ACE Statement on SGLT-2 Inhibitors and DKA Association",The AACE and ACE issue a position statement regarding the possible increased risk of diabetic ketoacidosis among patients taking SGLT-2 inhibitors.
  November 2016 ,Seminars in Respiratory and Critical Care Medicine,Metastatic Lung Cancer: Emerging Therapeutic Strategies,Have emerging therapies improved patient outcomes in metastatic non-small cell lung cancer?
  November 2016 ,U.S. Pharmacist,A Review of Systemic Lupus Erythematosus,Review the clinical features of SLE and the wide variety of medications and non-pharmacologic therapies which are used to target its symptoms in this primer.
  November 2016 ,American Heart Journal,Cardiac Rehab vs. Usual Care After Catheter Ablation for AF,Does comprehensive cardiac rehabilitation improve outcomes for patients treated with catheter ablation for atrial fibrillation?
  November 2016 ,Clinical Endocrinology,Growth Hormone Enhances Anaerobic Capacity,Growth hormone replacement therapy may help improve physical function and quality of life among GH-deficient adults.
  November 2016 ,Endocrine Practice,The Impact of Age in the Management of Hypothyroidism,Should patient age be a consideration when determining the thyroid-stimulating hormone target for treatment in hypothyroidism?
  November 2016 ,Current Opinion in Gastroenterology,Functional Dyspepsia,"This review summarizes new insights into our understanding of the etiology and epidemiology of functional dyspepsia, and explores recent and emerging advances in treatment."
  November 2016 ,Wounds,Bioimplant Dressing vs Wet Dressing for Diabetic Foot Ulcers,How do these two forms of wound dressings compare in terms of healing diabetic foot ulcers?
  November 2016 ,Clinical Journal of Oncology Nursing,Big Data and Pharmacovigilance: The Role of Oncology Nurses,Find out how oncology nurses can contribute to the safety of newly approved anticancer medications by reporting adverse effects.
  November 2016 ,American Journal of Clinical Pathology,A Clinicopathologic Analysis of Metaplastic Breast Carcinoma,"The authors detail the clinicopathologic features, treatment, and outcomes of 45 patients with metastatic breast cancer; most with high-grade, triple negative disease."
  November 2016 ,Critical Care,Surviving Critical Illness: What Is Next?,A new expert consensus provides guidance for the physical rehabilitation of critically ill patients after hospital discharge.
  November 2016 ,Annals of Family Medicine,Nifedipine vs Placebo for Treatment of Chronic Chilblains,Should nifedipine be prescribed for chilblains? Is it more effective than placebo?
  November 2016 ,Wounds,Surfactant-Based Dressing to Improve Wound Closure Rates,A new surfactant-based antimicrobial wound dressing may help improve outcomes for nonhealing wounds.
  November 2016 ,Journal of the American College of Cardiology,Challenges of Early Feasibility Studies of Medical Devices,"How can the recently enacted U.S. Early Feasibility Study program for medical device testing be optimized to meet the goal of improving access to early-stage, potentially beneficial devices?"
  November 2016 ,American Journal of Public Health,120 000 Nurses Who Shook Public Health,The Nurses' Health Study has contributed enormously to global health -- more evidence that nurses are wonderful.
  November 2016 ,Annals of Oncology,Expectations of AE on Outcomes of Endocrine Treatment,Do negative expectations for endocrine therapy-associated adverse effects increase the risk of nonadherence?
  November 2016 ,Critical Care Medicine,Practice Guidelines for Sustained Neuromuscular Blockade,This article provides updated recommendations for the use of neuromuscular-blocking agents in adult ICU patients.
  December 2016 ,Journal of Cardiovascular Electrophysiology,Single vs. Multiple Ablations in Ventricular Tachycardia,Are multiple catheter ablation procedures necessary in order to achieve long-term clinical success in ventricular tachycardia?
  December 2016 ,Skin Therapy Letter,Ixekizumab for Moderate-to-Severe Plaque Psoriasis,"The anti-IL-17 monoclonal antibody, ixekizumab, is a recently approved biologic therapy for moderate-to-severe plaque psoriasis. What are the findings from the latest clinical trials?"
  December 2016 ,Journal of the American College of Cardiology,Natural History Study of Coronary Atherosclerosis Using FFR,Can stenosis severity as assessed by fractional flow reserve serve as an independent predictor of lesion-related outcome?
  December 2016 ,Clinical Endocrinology,Antithyroid Drugs During Breastfeeding,What do we know about the use of antithyhroid medications during lactation?
  December 2016 ,Journal of Viral Hepatitis,LDV/SOF and Patient-reported Outcomes in HCV/HIV Co-infection,Do HIV/HCV patients treated with the recently approved fixed-dose combination of ledipasvir and sofosbuvir feel the regimen significantly improved their health-related quality of life?
  December 2016 ,American Journal of Transplantation,Outcomes in Belatacept-vs CsA-Treated ECD Kidney Recipients,How did these immunosuppressive regimens measure up in terms of efficacy and safety?
  December 2016 ,Journal of the American Geriatrics Society,Knowledge Gaps in Cardiovascular Care of Older Adults,This joint statement summarizes current guideline recommendations for cardiovascular care as they apply to older adults. What critical knowledge gaps still need to be addressed?
  December 2016 ,Journal of the American Board of Family Medicine,Course of Fluoroquinolones in Outpatient Males With a UTI,Can men with UTIs be successfully treated with a 5-day course of levofloxacin instead of the longer course which is currently recommended?
  December 2016 ,Journal of the American Academy of Orthopaedic Surgeons,Pediatric and Adolescent Forearm Fractures,Current guidelines for managing forearm fractures in children and teens remains controversial. Can these fractures be safely treated nonoperatively?
  December 2016 ,Pain,Opioids for Cancer Patients in the Last Year of Life,Are cancer patients receiving adequate opioid pain control in their last months?
  December 2016 ,BMC Pulmonary Medicine,Tiotropium Respimat vs Tiotropium HandiHaler in COPD,These inhalers provide two options for the delivery of tiotropium in patients with COPD. Find out how they compare.
  December 2016 ,Pediatric Pharmacotherapy,Ketamine Infusions for Pediatric Sedation and Analgesia,Ketamine is commonly used for procedural sedation and analgesia. How safe is it in children?
  December 2016 ,The British Journal of Dermatology,Oral Fumaric Acid Esters for Psoriasis,Are fumaric acid esters safe and effective for the treatment of psoriasis? This Cochrane review examines the best available evidence.
  December 2016 ,Annals of Oncology,Predictors of Chemotherapy Efficacy in NSCLC,"Can biomarkers predict the efficacy of conventional chemotherapy, such as gemcitabine and pemetrexed, for treatment of NSCLC?"
  December 2016 ,Headache,Noninvasive Brain Stimulation and Pain Control in Migraine,"Might noninvasive brain stimulation techniques, such as transcranial magnetic stimulation or transcranial direct current stimulation, provide relief for migraine pain?"
  December 2016 ,Current Opinion in Urology,Immunotherapy in Genitourinary Malignancies,What is our current understanding regarding the use of immunotherapies in the treatment of genitourinary malignancies? Find out what there is to know.
  December 2016 ,Anesthesiology,Better Sleep in the ICU: Blue Pill or Red Pill... or No Pill?,What is the best way to improve sleep in the ICU? Does pharmacologically induced sleep offer more benefit than sedation--or should we be focusing on promoting a non-drug approach?
  December 2016 ,Clinical Gastroenterology and Hepatology,Accuracy of Colon Capsules in Detection of Colorectal Polyps,"Can a new generation of capsule used in colon capsule endoscopy mitigate the criticisms of earlier versions, which were found to have suboptimal accuracy?"
  December 2016 ,Journal of the American Geriatrics Society,Influenza Vaccine Strategies for Elderly Adults,There are now four different influenza vaccines available in the United States for persons aged 65 and older. Are the newer iterations worth their additional cost?
  December 2016 ,Europace,Atrial Fibrillation and Risk of Stroke,Atrial fibrillation is a well-established risk factor for ischemic stroke. But how much of that risk is dependent on concomitant stroke risk factors?
  January 2017 ,Southern Medical Journal,Secondary Stroke Prevention in Nonvalvular AF,"This review offers evidence-based guidance to clinicians on appropriate stroke prevention therapies in patients with nonvalvular atrial fibrillation, along with a cost-effectiveness analysis."
  January 2017 ,Pediatric Pharmacotherapy,Amphetamine Orally Disintegrating Tablets for ADHD,A newly approved extended-release orally disintegrating amphetamine tablet may be another option for the treatment of ADHD.
  January 2017 ,Journal of the American Board of Family Medicine,Avoiding Myalgia With Statin Therapy in Exercising Adults,What's the best strategy for minimizing symptoms of statin-induced myopathy in adults who wish to continue exercising?
  January 2017 ,Wounds,Zinc-Coated Foam With NPWT for Treating Challenging Wounds,The use of zinc-coated foam in conjunction with negative pressure wound therapy was shown to be a safe and effective option in the treatment of challenging wounds.
  January 2017 ,Menopause,Calcium Plus Vitamin D Supplementation and Height Loss,Might calcium along with vitamin D supplementation prevent height loss in postmenopausal women?
  December 2016 ,Southern Medical Journal,Deep Brain Stimulation for Treatment-Refractory Depression,"While deep brain stimulation has shown promise in treating resistant depression, it is still considered experimental. What is the latest evidence regarding its use in depression?"
  December 2016 ,HIV Medicine,"Psychiatric, Substance Use Disorders in HIV/HCV Coinfection",This study looks at the prevalence of psychiatric disorders and substance abuse among coinfected patients. Do the patterns differ according to individual HCV status?
  December 2016 ,Journal of the American Geriatrics Society,Caring for Older Adults With HIV,An increasing number of older adults are HIV positive. How might treatment strategies in this unique population differ from those for their younger cohorts?
  December 2016 ,American Heart Journal,Factors Associated With Diabetes Among Patients With HF,Has the association between diabetes and heart failure been under recognized? This study examined the prevalence of diabetes among US adults hospitalized with heart failure and its impact on outcomes.
  December 2016 ,American Journal of Transplantation,The Current State of Liver Transplantation in the US,Get up-to-date on the current state of knowledge in the field of liver transplantation.
  December 2016 ,Pediatric Nursing,Current Recommendations on Managing Pediatric Concussions,What are the currently recommended strategies for the diagnosis and care of children with concussion?
  December 2016 ,U.S. Pharmacist,Updates in the Management of Seasonal Allergic Rhinitis,Intranasal corticosteroids and oral antihistamines remain the mainstay of treatment for seasonal allergic rhinitis. Review the use of both prescription and OTC options in this report.
  December 2016 ,Southern Medical Journal,Diabetes Mellitus and the Skin,"Cutaneous disease may appear as the first sign of diabetes mellitus, or may develop as a result of microvascular complications. Which skin disorders are most commonly encountered?"
  December 2016 ,The Gerontologist,Pain Management Among Older Patients During Care Transition,Moderate to severe pain remains a common problem among hospitalized older adults. Are they being given adequate pain management when transitioned to skilled nursing facilities?
  December 2016 ,Endocrine Practice,Advances in Clinical Applications of Bone Imaging Technology,Read about the advances in bone imaging technology to aid in the assessment of bone density and fracture risk.
  December 2016 ,Rheumatology,The Gut-Brain Connection,Learn more about the connection between commensal gut bacteria and autoimmune disease.
  December 2016 ,Journal of the American College of Cardiology,Determining When to Add Nonstatin Therapy,"The availability of non-statin cholesterol lowering drugs, such as ezetimibe or PCSK9 inhibitors, has the potential to change lipids management; but for whom should they be prescribed?"
  December 2016 ,Journal of Medical Case Reports,Rivaroxaban for Postoperative DVT of the Lower Limb,"Is rivaroxaban a safe and effective approach to postsurgical deep vein thrombosis after extended, but failed, warfarin therapy?"
  December 2016 ,Europace,Syncope in Patients Paced for Atrioventricular Block,Is cardiac pacing effective in preventing syncope in patients with atrioventricular block?
  December 2016 ,Journal of the American Board of Family Medicine,A Clinical Aid for Detecting Skin Cancer,"A new, simplified dermoscopy algorithm for skin cancer detection can help primary care physicians identify lesions that require skin biopsy or specialist referral."
  January 2017 ,Annals of Surgery,Transfused Blood Age Impacts Outcomes in Major GI Surgery,"The use of older packed red blood cells for transfusion may negatively impact postoperative outcomes of gastrointestinal surgery, a new study reports."
  January 2017 ,Circulation,A Critical Appraisal of Aspirin in Secondary Prevention,This article examines the viability of the continuing role of aspirin in secondary prevention of cardiovascular disease. Is it time to revisit aspirin as the cornerstone of antithrombotic therapy?
  January 2017 ,Critical Care,Association Between Time of ICU Discharge and Mortality,"When it comes to reducing the risk of in-hospital mortality among critically ill patients, does ICU discharge time matter?"
  January 2017 ,Liver International,Ribavirin Revisited in the Era of DAAs for HCV Infection,"What is the role of ribavirin in interferon-free, direct-acting antiviral HCV treatment? For which group of patients might it continue to provide clinical benefit?"
  January 2017 ,HIV Medicine,Adverse Events Leading to Dolutegravir Discontinuation,Might the potential neurotoxicity associated with dolutegravir be the reason for higher discontinuation rates of this antiretroviral agent?
  January 2017 ,Brain,Brain Networks: Robustness and the Impact of Lesions,"Approaching the brain as a complex network, the authors examine what types of damage the brain can withstand--its ""robustness""--and how tumors, stroke and TBI might impact network function."
  January 2017 ,American Journal of Epidemiology,Maternal Influenza Immunization and Adverse Birth Outcomes,Are studies affirming the magnitude of fetal benefit conferred by maternal influenza immunization accurate--or is the methodology flawed?
  January 2017 ,Journal of Clinical Endocrinology & Metabolism,Factors and 25(OH)D Responses to Vitamin D Supplementation,A new study examines how genetic and nongenetic factors may impact responses of vitamin D supplementation.
  January 2017 ,Journal of Clinical Endocrinology & Metabolism,Caloric Restriction Effects on Muscle Mitochondrial Function,"In this study, the changes in muscle mitochondrial function after long-term caloric restriction are evaluated."
  January 2017 ,Journal of Clinical Endocrinology & Metabolism,CLA and Metformin Effects on Insulin Sensitivity,Could metformin and conjugated linoleic acid help improve insulin sensitivity among children with obesity?
  January 2017 ,OJIN: The Online Journal of Issues in Nursing,Why Causal Inference Matters to Nurses,"The authors discuss the importance of causal inference in nursing research, focusing on the causal pathways between nurse staffing and patient outcomes."
  January 2017 ,Circulation,A Protagonist View From the SPRINT Trial,"In this point-counterpoint, the authors make the case for providing older hypertensive patients at high cardiovascular risk with intensive treatment to a target systolic blood pressure of <120 mm Hg."
  January 2017 ,Morbidity & Mortality Weekly Report,Chronic Fatigue Syndrome -- Advancing Research and Education,"This overview addresses the public health impact of myalgic encephalomyelitis/chronic fatigue syndrome, as well as current best evidence as to its cause and clinical approach."
  January 2017 ,Age and Ageing,The Management of Hypertension in People With Dementia,Might antihypertensive therapy do more harm than good in some patients with dementia?
  January 2017 ,Pain,Open-label Placebo Treatment in Chronic Low Back Pain,Can a placebo treatment improve chronic low-back pain--even when the patient is aware that it's a placebo?
  January 2017 ,Alimentary Pharmacology & Therapeutics,BMI >35 Is Associated With Severe C. Difficile Infection,This study examines the correlation between body mass index and C. difficile infection severity.
  January 2017 ,American Journal of Public Health,HPV Vaccination and Prevalence of Cervical Dysplasia,How has the prevalence of low- and high-grade cervical lesions in young women been impacted by the availability of the HPV vaccine?
  January 2017 ,American Heart Journal,Bleeding Risk Following PCI in Diabetic Patients on DAPT,Do patients with diabetes mellitus have an increased risk of bleeding when prescribed dual-antiplatelet therapy following PCI?
  January 2017 ,Journal of the American College of Cardiology,Causes of Death in Anticoagulated Patients With AF,This study aimed to analyze and compare causes of death in patients with atrial fibrillation receiving direct oral anticoagulants or warfarin for prevention of stroke and thromboembolism.
  January 2017 ,AIDS,Real-Life Experience With Sorafenib for HCC in HIV Patients,A new study provides insight into the real-life efficacy of sorafenib among HIV-infected patients with hepatocellular carcinoma.
  February 2017 ,HIV Medicine,"Age, Time Living With Diagnosed HIV, and Self-Rated Health",This new study examines the impact of age at diagnosis and time living with HIV on quality of life among people living with the virus.
  February 2017 ,Endocrine Practice,Hyperthyroidism and Hyperprolactinemia,A new study explores the possible connection between these two conditions in women. What role do prolactin levels play?
  February 2017 ,Urologic Nursing,The Effects of a Take-Home Educational Video,A take-home educational video benefits both prostate cancer patients and urology practitioners. Find out how.
  February 2017 ,Current Opinion in Allergy and Clinical Immunology,Allergen Immunotherapy: An Updated Review of Safety,What does the latest safety data tell us about the use of allergen immunotherapy?
  February 2017 ,AIDS,Early Age at Start of ART for Better Virologic Control,Initiating ART earlier in life may help improve virologic outcomes among infants and children with HIV.
  February 2017 ,Skin Therapy Letter,Brodalumab for Moderate-to-Severe Plaque Psoriasis,"The investigational drug brodalumab, an IL-17 receptor antagonist, has proven highly effective for the treatment of moderate-to-severe psoriasis; but questions remain concerning its safety."
  February 2017 ,Liver International,Hepatotoxicity of Statins and Other Lipid-lowering Agents,How common is liver injury associated with statins? This review summarizes current knowledge on the hepatotoxicity associated with statins and other lipid lowering drugs.
  February 2017 ,Pain,Phenotypes and Treatment Response,"In this commentary, the author examines the role of sensory phenotyping in our effort to understand the underlying pathophysiology of pain. How can these findings be translated to clinical practice?"
  February 2017 ,Journal of Pediatric Health Care,Weight and QoL and Health Outcomes in Children With Asthma,In what ways may weight impact quality of life and health outcomes among children with asthma?
  February 2017 ,Alcohol and Alcoholism,Readiness to Change Predicts Drinking,"This study examined whether three RTC measures--RTC, importance of change, and confidence in ability to change--had predictive value for alcohol use in patients with an alcohol use disorder."
  February 2017 ,AIDS,Tenofovir Disoproxil Fumarate Safety for Women and Infants,What does available safety data tell us about preexposure prophylaxis with tenofovir disoproxil fumarate during pregnancy and lactation?
  February 2017 ,HIV Medicine,HIV-Positive People's Attitudes Towards Cure Research,How do people living with HIV feel about the importance of and risks involved in HIV cure research?
  February 2017 ,BMC Pulmonary Medicine,Adiposity Markers and Lung Function in Smokers,What is the association between adiposity markers and lung function? This study examines the connection among smokers without respiratory disease.
  February 2017 ,The British Journal of Dermatology,Antihistamine Updosing in Chronic Urticaria,Is updosing of second-generation H1-antihistamines justified in all patients with chronic urticaria who don't respond sufficiently to standard dosages?
  February 2017 ,Journal of Viral Hepatitis,12 Weeks of Ledipasvir-Sofosbuvir for Genotype 1 Hepatitis C,Does real-world experience with ledipasvir-sofosbuvir for genotype 1 HCV mirror the sustained viral response rates observed in clinical trials?
  February 2017 ,Endocrine Practice,Revisiting the Use of Pioglitazone in the Treatment of T2D,Is it time to reconsider the role of pioglitazone in the management of type 2 diabetes?
  February 2017 ,American Journal of Epidemiology,Consumption of Unprocessed and Processed Red Meat and COPD,Consumption of both processed and unprocessed red meat has been associated with an increased risk of several chronic diseases. Should COPD be included in the list?
  February 2017 ,Morbidity & Mortality Weekly Report,Identifying Inaccurate Cause of Death Reporting,"This study revealed substantial overreporting of certain conditions and underreporting of others as underlying causes of hospital deaths, which can lead to skewing of mortality statistics."
  February 2017 ,BMC Pulmonary Medicine,Extrafine pMDI Beclometasone/Formoterol in Asthma,An extrafine pMDI formulation containing a fixed dose combination of beclometasone and formoterol may be a viable therapeutic alternative to inhaled corticosteroids for asthma.
  February 2017 ,Stroke,Predicting Long-term Functional Outcomes in Ischemic Stroke,How does longitudinal National Institutes of Health Stroke Scale measurement compare to other early markers of stroke severity in predicting 90-day stroke outcome?
  March 2017 ,HIV Medicine,EVG Concentrations in Seminal Plasma in HIV-1-Infected Men,A new study examines elvitegravir concentrations in the semen of men who switched antiretroviral therapy to EVG/COBI/FTC/TDF. What are the implications for HIV suppression?
  March 2017 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Psychiatric Symptoms in Patients Receiving Dolutegravir,Which psychiatric symptoms may be associated with the use of this antiretroviral drug -- and how often do they occur?
  March 2017 ,Journal of the National Cancer Institute,Industry-Related Payments to Oncologists in 2014,Research finds that financial relationships between oncologists and biomedical industries are common. Should we worry about conflict of interest?
  March 2017 ,Current Opinion in Nephrology and Hypertension,Renal Denervation for Uncontrolled Hypertension,Is renal denervation an effective option for managing uncontrolled hypertension?
  March 2017 ,Journal of the National Cancer Institute,Prognostic Tests for Prediction of Breast Cancer Recurrence,Which prognostic assay best predicts which patients may need adjuvant chemotherapy after endocrine therapy?
  March 2017 ,Current Opinion in Allergy and Clinical Immunology,Strategies to Alter the Natural History of Childhood Asthma,A new review examines recent evidence regarding approaches that may help alter the course of childhood asthma. What have we learned?
  March 2017 ,Journal of Medical Case Reports,Surgery for Vertebral Metastases: A Benefit in Lung Cancer?,"Surgical intervention for spinal metastasis has been considered less appropriate in lung cancer than in other cancers, but recent gains in expected survival may change that supposition."
  March 2017 ,Current Opinion in Rheumatology,Major Unanswered Questions in the Clinical Gout Field,"Advancing research has contributed to the understanding of gout and the development of new therapies, but certain questions remain."
  March 2017 ,BMC Anesthesiology,Anesthesia Impact on Arterial O2 During Thoracoscopic Surgery,Is either desflurane-remifentanil or propofol-remifentanil anesthesia preferable in terms of oxygenation during one-lung ventilation for thoracoscopic surgery?
  March 2017 ,Wounds,Mesenchymal Stem Cells: 'Guardians of Inflammation',Find out how human mesenchymal stem cells might help protect against inflammation -- and learn how this knowledge can apply to the treatment of chronic wounds.
  March 2017 ,Journal of the American College of Cardiology,Proposed Neurological Endpoints for Cardiovascular CTs,The Neurologic Academic Research Consortium has developed pragmatic definitions and assessments for neurological injury following cardiovascular procedures and interventions.
  March 2017 ,Clinical Gastroenterology and Hepatology,Biosimilars in IBD: Facts and Fears of Extrapolation,Can clinical data obtained on the efficacy of anti-TNF biosimilars in rheumatologic populations be confidently extrapolated to patients with inflammatory bowel disease?
  March 2017 ,Critical Care,Vasopressin and Terlipressin for Pediatric Refractory Shock,How does the safety and efficacy of asopressin and terlipressin therapy compare with that of conventional therapy?
  March 2017 ,European Heart Journal,Insufficient Cardiovascular Research & Development Funding,"In this commentary, the author addresses disparities and deficiencies in research for cardiovascular disease, with a focus on the paucity of R&D funding in the European Union."
  March 2017 ,AIDS,Switching From ATV or LPV to DRV Improves Kidney Function,HIV patients who switched their protease inhibitor to darunavir realized an improvement in renal function.
  March 2017 ,Pediatric Pharmacotherapy,Hydrocortisone in Managing Bronchopulmonary Dysplasia,Is hydrocortisone a safe and effective treatment option for the prevention and treatment of bronchopulmonary dysplasia?
  March 2017 ,Journal of the American College of Cardiology,Safety of Very Low LDL Cholesterol Levels With Alirocumab,New lipid-lowering drugs such as alirocumab can reduce LDL to levels below 25mg/dl. Do these very low levels have safety implications?
  March 2017 ,Liver International,Treatment of HCV Genotype 2 With Sofosbuvir and Ribavirin,"Sofosbuvir and ribavirin have been suggested as the new standard therapy for HCV genotype 2, but the results of this study suggest an alternative treatment strategy may be needed."
  March 2017 ,Journal of Viral Hepatitis,Simeprevir+Sofosbuvir in Patients With HCV Genotype 4,"The OSIRIS study assessed the efficacy of simeprevir plus sofosbuvir for HCV genotype 4-infected patients, on either an 8 or 12 week regimen."
  March 2017 ,Medicine and Science in Sports and Exercise,"Weight Loss and Lean Mass, Strength, Bone, Aerobic Capacity",How does weight loss impact these parameters among overweight sedentary adults?
  April 2017 ,Skin Therapy Letter,Tofacitinib for Rheumatoid Arthritis and Plaque Psoriasis,"Review the latest data on the oral immunosuppressant tofacitinib, recently approved for the treatment of rheumatoid arthritis, and currently in Phase III trials for treating chronic plaque psoriasis."
  April 2017 ,U.S. Pharmacist,Treatment of Parkinson's Disease Psychosis,What is the best approach to treating delusions and hallucinations in patients with Parkinson's disease? A recently approved antipsychotic provides a new option.
  April 2017 ,Journal of Clinical Endocrinology & Metabolism,Body Composition Changes After Low-Calorie Ketogenic Diet,In what ways is the body composition of obese patients impacted after following a very-low-calorie ketogenic diet?
  April 2017 ,Clinical Endocrinology,Maternal 25-hydroxyvitamin D Correlated With Fetal Serotonin,A new study explores the associations between maternal serum 25-hydroxyvitamin D concentrations during pregnancy and fetal serotonin.
  April 2017 ,Rheumatology,Biosimilars in Rheumatology: Understanding the Development,This article provides an overview of the development of biosimilars for the treatment of rheumatologic conditions.
  April 2017 ,Alimentary Pharmacology & Therapeutics,Assessment of Treatment Response in NASH Using Advanced MRI,How well do MRI derived measures of liver fat and volume correlate to histological features of non-alcoholic steatohepatitis over time?
  April 2017 ,Translational Andrology and Urology,Ejaculatory Dysfunction -- Evolution of a New Understanding,"How has our understanding of premature ejaculation evolved in recent years, and how has it changed approaches to diagnosis and treatment?"
  April 2017 ,HIV Medicine,Trends and Patterns in HIV-1 Transmitted Drug Resistance,What do we know about the prevalence of HIV-1 transmitted drug resistance in the UK in recent years? This report examines the trends.
  April 2017 ,Circulation,Women Less Likely Than Men to Be Full Professors in Cardiology,Statistics show that gender bias is still prevalent in academia. What barriers persist for women's career advancement in academic cardiology?
  April 2017 ,Journal of the Endocrine Society,Subclinical Hypothyroidism and Cardiometabolic Biomarkers,A new study explores the possible relationship between subclinical hypothyroidism and cardiometabolic abnormalities in women.
  April 2017 ,Journal of the American College of Cardiology,2016 Annual Report of The STS/ACC TVT Registry,This annual report provides an update regarding the trends and outcomes of transcatheter valve procedures.
  April 2017 ,Critical Care,Can BMI Predict Clinical Outcomes in Acute Lung Injury/ARDS?,A new study explores the ways in which a patient's BMI may impact outcomes in acute respiratory distress syndrome.
  April 2017 ,BMC Anesthesiology,Is Propofol Injection Pain Really Important to Patients?,"Pain on injection of propofol is a common occurrence, but do patients generally recall it, and does it negatively impact their experience?"
  April 2017 ,Menopause,Hormone Therapy and Changes in Menopausal Symptoms Over Time,"This study compared the efficacy of two forms of menopausal hormone therapy in alleviating vasomotor symptoms, insomnia, and irritability in early postmenopausal women over a period of 4 years."
  April 2017 ,Pediatric Pharmacotherapy,Precision Medicine in Children,"Review applications in Autoimmunity, Asthma, Infectious Disease, and Many Other Critical Areas"
  March 2017 ,Journal for Nurse Practitioners,Informed Consent: Ethical and Legal Considerations,"As patient advocates, nurse practitioners can play a key role in the informed consent process. Find out the ethical and legal aspects to be aware of."
  March 2017 ,Journal of the American College of Cardiology,Trending Cardiovascular Nutrition Controversies,What do we know about the potential cardiovascular benefits of popular food and dietary trends?
  March 2017 ,Alimentary Pharmacology & Therapeutics,Defining Endoscopic Response in Ulcerative Colitis Trials,These international recommendations represent the first consensus on measurement indices for endoscopic outcomes in ulcerative colitis.
  March 2017 ,American Journal of Public Health,Suicide Deaths With Opioid Poisoning in the US: 1999-2014,Are suicides involving opioids on the increase?
  March 2017 ,American Journal of Clinical Pathology,HER2 and Decision Making in Gastroesophageal Adenocarcinoma,This new guideline provides specific recommendations for assessment of HER2 status in patients with advanced gastroesophageal adenocarcinoma.
  May 2017 ,Alimentary Pharmacology & Therapeutics,Fecal Microbiota Transplantation for Recurrent C. difficile,How do different donor products compare overall and in terms of resolution of C. difficile infection?
  May 2017 ,Brain,"Alzheimer's Disease: Focus on the Brain, Not Just Molecules",Several recent failed trials have dealt a blow to the development of Alzheimer disease therapies aimed at molecular targets of amyloid and tau. Where do we go from here?
  May 2017 ,American Journal of Epidemiology,Use of a Single Cutpoint to Identify High BP in Adolescents,This study evaluated the risk for misclassification when using the International Diabetes Federation single-cutpoints criteria for high blood pressure in adolescents.
  May 2017 ,Translational Andrology and Urology,Immunotherapy in Urothelial Carcinoma,A new review examines the role of immunotherapy in the treatment of urothelial bladder carcinoma.
  May 2017 ,Plastic and Reconstructive Surgery,Facial Contouring by Targeted Restoration of Facial Fat,The authors describe a grafting technique for the targeted restoration of midface fat compartment volume.
  May 2017 ,Liver International,Multiclass HCV Resistance to DAA Failure,This study aimed to define the pattern of clinically relevant resistance-associated substitutions associated with real-life DAA virological failures.
  May 2017 ,HIV Medicine,A New Measure of Engagement in Out-Patient HIV Care,The authors describe the development and implementation of a new measure of engagement in HIV care.
  April 2017 ,Journal of the American Geriatrics Society,Osteoporosis Treatment Efficacy for Men,"While osteoporotic fractures are most often studied in women, men are affected as well. Which osteoporosis treatment options offer the best protection for men?"
  April 2017 ,Medicine and Science in Sports and Exercise,Instability Resistance Training in Parksinson's Disease,Find out about the neuromuscular benefits instability resistance training may offer patients with Parkinson's disease.
  April 2017 ,American Journal of Pharmaceutical Education,Pharmacists and Pharmacy Education in Point-of-Care Testing,"What are the issues and challenges for pharmacists surrounding point-of-care testing, particularly when performed outside traditional health care settings?"
  April 2017 ,Cancer Control: Journal of the Moffitt Cancer Center,Management of Oropharyngeal Cancer in the HPV Era,The incidence of head and neck cancer associated with HPV has increased at an epidemic rate. Review prevention and management strategies here.
  April 2017 ,Current Opinion in Gastroenterology,Optimizing the Diagnosis of Celiac Disease,"This review provides a summary of recent advances in the diagnosis of celiac disease, focusing on diagnostic challenges and the phenotypical characterization of celiac subtypes."
  April 2017 ,HIV Medicine,Direct-Acting Antivirals in HCV and HCV/HIV Coinfection,Does the success of oral direct-acting antivirals seen in clinical trials translate to real-world clinical practice?
  April 2017 ,Current Opinion in Ophthalmology,Clinical Investigation of New Glaucoma Procedures,How effective are the new glaucoma procedures for targeting aqueous outflow? A review of current evidence provides some insight.
  April 2017 ,Journal of the American Geriatrics Society,Impaired Orthostatic BP Recovery and Falls,To what extent does orthostatic hypotension contribute to falls in the elderly?
  April 2017 ,Journal of the American College of Cardiology,Potent P2Y12 Inhibitors in Men Versus Women,"Do women and men derive comparable benefit from antiplatelet therapy with potent P2Y12 inhibitors such as prasugrel, ticagrelor and cangrelor?"
  April 2017 ,Alimentary Pharmacology & Therapeutics,Pharmacotherapy for Alcohol Dependence,Find out more about the pharmacotherapeutic options for alcohol dependence and learn which patients would most benefit from drug treatment.
  April 2017 ,Translational Andrology and Urology,Emerging and Investigational Drugs for Premature Ejaculation,Find out what there is to know about the newest agents for the pharmacologic treatment of premature ejaculation.
  April 2017 ,Seminars in Neurology,EEG as a Prognostic Tool After Cardiac Arrest,What prognostic information can be obtained by continuous EEG monitoring and routine EEG after cardiac arrest?
  April 2017 ,Critical Care Medicine,Bedside Glucose Monitoring--Is it Safe?,A new study examines the question of whether a bedside glucose monitoring system is accurate and safe for use in critically ill patients.
  May 2017 ,Translational Andrology and Urology,"Erectile Dysfunction, Masculinity, and Psychosocial Outcomes",A new review provides insight into the physical and psychosocial impacts of prostate cancer treatment.
  May 2017 ,BMC Pulmonary Medicine,Switch of NIV to CPAP in Obesity Hypoventilation Syndrome,What benefits could switching from non-invasive ventilation to CPAP treatment offer patients with obesity hypoventilation syndrome?
  May 2017 ,Journal of the American Academy of Orthopaedic Surgeons,Lumbar Spinal Stenosis: How Is It Classified?,A unified classification system for lumbar spinal stenosis is needed to help guide appropriate treatment for the condition.
  May 2017 ,Journal of Clinical Endocrinology & Metabolism,Effect of Physical Activity or Healthy Eating on GDM Risk,Could engaging in regular physical activity and a healthier diet help prevent gestational diabetes mellitus?
  May 2017 ,Journal of the American Academy of Orthopaedic Surgeons,Patellar Tendinopathy: Diagnosis and Treatment,Learn more about the differential diagnoses for patellar tendinopathy and the surgical and non-surgical treatment options.
  May 2017 ,AIDS,Drug Interactions Between Hormonal Contraceptives and ART,Could antiretroviral drugs for the treatment or prevention of HIV adversely impact the contraceptive efficacy of hormonal birth control methods?
  May 2017 ,American Journal of Clinical Dermatology,Alopecia Areata: Current Practices vs. New Directions,"Many treatments for alopecia areata are available, but none have been validated or are FDA approved. This paper reviews therapies currently under investigation and novel modalities which show promise."
  May 2017 ,Arthritis Research & Therapy,Minimal Disease Activity and Impact of Disease in PsA,What is the association between minimal disease activity and the impact of psoriatic arthritis?
  May 2017 ,American Journal of Epidemiology,AF and Risk of Invasive Breast and Colorectal Cancer,"Is there an association between atrial fibrillation and breast or colorectal cancer--and if so, how might it be explained?"
  May 2017 ,Translational Andrology and Urology,Testosterone Therapy and Prostate Cancer,Is testosterone therapy safe to use in men with a history of prostate cancer?
  May 2017 ,Skin Therapy Letter,Guselkumab for Moderate-to-Severe Plaque Psoriasis,"Guselkumab, an interleukin-23 inhibitor currently in Phase III trials, is a promising new therapy for moderate-to-severe plaque psoriasis. What do we know so far?"
  May 2017 ,Laboratory Medicine,PCR-RFLP Method for Genotyping in Patients With Chronic HCV,"The authors present a rapid, inexpensive, and easy to perform method for genotyping of the IFNL4 rs368234815 polymorphism in hepatitis C."
  May 2017 ,Current Orthopaedic Practice,Current Trends in Orthobiologics and Shoulder Surgery,Get up to date on the latest trends in the use of biologics for the treatment of shoulder disease.
  May 2017 ,Circulation,Fire Simulation and Cardiovascular Health in Firefighters,Why do firefighters experience such a high rate of myocardial infarction during fire suppression activity? This study examines the pathogenic mechanisms behind the heightened risk.
  May 2017 ,BMC Oral Health,QoL With Mini vs. Conventional Implant Retained Dentures,Can mini implants provide a cost-effective alternative to conventional implants for denture patients with total tooth loss?
  May 2017 ,Alimentary Pharmacology & Therapeutics,Vedolizumab Exposure in Pregnancy: Outcomes in IBD,What does current safety data tell us about the effects of exposure to vedolizumab in pregnancy?
  May 2017 ,Breast Cancer Research,Palbociclib With Letrozole for ER-positive Breast Cancer,Addition of this CDK inhibitor to aromatase inhibitor therapy may increase PFS in patients with ER+ advanced breast cancer.
  May 2017 ,American Journal of Epidemiology,"Milk, Fruit, Vegetable, and Antioxidant Intake and Mortality",Might high milk consumption shorten life span through increased oxidative stress? Can the risk be modified by fruit and vegetable intake or total antioxidant intake?
  May 2017 ,HIV Medicine,Screening and Risk Assessment for CAD in HIV,Are HIV-infected patients being appropriately screened for cardiovascular disease? This editorial explores the issue.
  May 2017 ,Annals of Oncology,Resistance to Anticancer Immunity in Cancer Patients,What options are available for patients who develop resistance to cancer immunotherapy?
  June 2017 ,Cancer Control: Journal of the Moffitt Cancer Center,Benefits of Proton Beam Therapy for Tumors of the Skull Base,Which patients with skull-base tumors benefit from proton beam therapy?
  June 2017 ,Nephrology Dialysis Transplantation,Efficacy and Safety of Nicotinamide in Hemodialysis Patients,Is nicotinamide a safe and effective alternative to sevelamer for the treatment of hyperphosphatemia in chronic hemodialysis patients?
  June 2017 ,The Journal of Emergency Medicine,The Use of Ketamine for Acute Treatment of Pain,Ketamine may be a safe and effective option for acute pain when used in subdissociative doses.
  June 2017 ,American Journal of Cardiovascular Drugs,Iron Therapy in Patients With HF and Iron Deficiency,"Iron deficiency is common in heart failure patients, but supplementation needs to be addressed differently than in healthy patients. What are the options?"
  June 2017 ,Laboratory Medicine,The Challenges of Daratumumab in Transfusion Medicine,"Daratumumab, used to treat multiple myeloma, attaches to the red blood cell reagents used in blood banks, complicating the antibody identification work-up. How can this issue be overcome?"
  June 2017 ,Journal of the American College of Cardiology,Antiphospholipid Syndrome: Role of Vascular Endothelial Cells,"This review explores the role of vascular endothelial cell dysfunction in antiphospholipid syndrome, an autoimmune prothrombotic condition. Might this pathway provide a viable target for therapy?"
  June 2017 ,Annals of Oncology,Immune Checkpoint Inhibition: Treating Higher Risk Patients,Are PD-1 inhibitors safe to use in patients with underlying autoimmune disorders?
  June 2017 ,Alimentary Pharmacology & Therapeutics,5-ASA and Risk of Colorectal Neoplasia in Patients With IBD,Might 5-aminosalicylates provide protection against colorectal neoplasia in patients with inflammatory bowel disease?
  June 2017 ,Arthritis Research & Therapy,Poor Prognostic Factors Guiding Treatment Decisions in RA,Prognostic factors are used to guide treatment strategies for rheumatoid arthritis -- but how are these factors currently defined?
  June 2017 ,Preventing Chronic Disease,CRFs Among Overweight or Obese Adults Without Diabetes,"This study examined the prevalence of 4 commonly measured cardiometabolic risk factors among adults with overweight or obesity, but not diabetes."
  May 2017 ,BMC Pulmonary Medicine,Reference Equations for Spirometric Indices,Spirometric measurements from a sample of adult Nigerians provides updated reference data for interpreting pulmonary function test results.
  May 2017 ,Pain,Spinal Cord Stimulation in Treatment of Chronic Pain,What are the indications and evidence for the use of spinal cord stimulation in the treatment of chronic pain? This brief review examines the long-term effectiveness and cost of current technologies.
  May 2017 ,Critical Care,Poor Outcome Predictors After Out-of-Hospital Cardiac Arrest,Find out which independent predictors may indicate a poor long-term outcome among survivors of out-of-hospital cardiac arrest.
  May 2017 ,Journal of the American College of Cardiology,Bioprosthetic Valve Thrombosis,"This article reviews the diagnostic challenges of bioprosthetic valve thrombosis, and details available therapeutic options, particularly within the rapidly expanding field of TAVR."
  May 2017 ,BMC Oral Health,Assessment of Periodontitis Using Subgingival Pathogen Levels,Can characterization of the bacterial content of subgingival plaque recovered from the deepest pockets be used to assess disease progression in chronic periodontitis patients?
  May 2017 ,Journal of the American Geriatrics Society,"Aging, the Medical Subspecialties, and Career Development",What progress has been made in integrating geriatrics and aging research into other medical subspecialties? This report summarizes recent collaborative work with several subspecialty associations.
  May 2017 ,Anesthesia & Analgesia,Perioperative Anesthesia Care and Tumor Progression,"Might the perioperative anesthesia care of patients with cancer impact the immune system, and how might that affect tumor growth and long-term oncological outcomes?"
  May 2017 ,Alimentary Pharmacology & Therapeutics,"CT-P13, a Biosimilar of Anti-TNF-a for IBD","Can CT-P13, a biosimilar of infliximab, be used safely in patients with inflammatory bowel diseases--and with comparable efficacy?"
  May 2017 ,Liver International,The Therapeutic Landscape of Non-alcoholic Steatohepatitis,What drugs are available for the treatment of non-alcoholic steatohepatitis? This review summarizes those currently in use as well as novel pharmacological options in ongoing trials.
  May 2017 ,Critical Care Medicine,Delays From First Medical Contact to Antibiotic in Sepsis,Might delays in antibiotic administration contribute to a greater risk of in-hospital mortality among sepsis patients?
  June 2017 ,European Heart Journal,Hybrid Intravascular Imaging for Plaque Pathophysiology,"Recent advances in hybrid intravascular imaging have overcome drawbacks of previous methods, allowing more accurate evaluation of plaque morphology and pathobiology."
  June 2017 ,Breast Cancer Research,Systemic Therapy and Risk of Contralateral Breast Cancer,"After completing tamoxifen or chemotherapy, how long does risk reduction for contralateral breast cancer last?"
  June 2017 ,Journal of the National Cancer Institute,NK-1RA-Based Triple Regimens in Preventing CINV,Do efficacy and toxicity vary among different NK-1RA-based triple regimens for prevention of CINV? What is the optimal dose of dexamethasone?
  June 2017 ,European Heart Journal,How Robust Are Clinical Trials in Heart Failure?,"The authors propose an additional, easy to understand metric--the 'fragility index'--to improve the statistical significance and robustness of heart failure RCTs."
  June 2017 ,Annals of Surgery,The Future of Basic Science in Academic Surgery,What challenges might impact the success of surgeon-scientists? This article explores the issues.
  June 2017 ,Rheumatology,Clinical Trials in Rheumatology. Does One Size Fit All?,This editorial explores why a one-size-fits-all approach may not work in rheumatology research.
  June 2017 ,Journal of the American College of Cardiology,"FFR: Accuracy, Prognostic Implications, and Limitations","While fractional flow reserve is not a difficult test to perform, technical factors can impair its accuracy. What are the pitfalls and limitations of FFR assessment and how can these be minimized?"
  June 2017 ,Wounds,Zinc and Wound Healing,Learn more about our current understanding of the role of zinc in wound healing.
  June 2017 ,Annals of Oncology,Nectin-4: Prognostic Biomarker for Targeting of TNBCs,An antibody-drug conjugate targeting nectin-4 shows promise against triple-negative breast cancer.
  June 2017 ,Journal of the American Geriatrics Society,"Alzheimer's Disease: Individuals, Communities, and Costs","In this paper, the author emphasizes that time is of the essence in building an effective system of care for persons with Alzheimer's disease. How can we do more to help family caregivers?"
  June 2017 ,Alimentary Pharmacology & Therapeutics,Biologics for Mucosal Healing in Crohn's Disease and UC,"Using mucosal healing as a therapeutic endpoint, this review aimed to determine the comparative efficacy of different classes of biologic therapy for treating Crohn's disease and ulcerative colitis."
  June 2017 ,BMC Anesthesiology,Leg Elevation and Post-spinal Hypotension in C-Section,Hypotension is a common complication after spinal anesthesia for cesarean section. Can leg elevation performed immediately after spinal block reduce the risk?
  June 2017 ,Age and Ageing,Mineralocorticoid Receptor Antagonists in Elderly HF Patients,This study investigated the efficacy and safety of mineralocorticoid receptor antagonists in older heart failure patients with both reduced and preserved ejection fraction.
  June 2017 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Efficacy and Safety After Switching From TDF to TAF in HIV,What benefits might tenofovir alafenamide offer virologically suppressed HIV patients over tenofovir disoproxil fumarate?
  June 2017 ,Annals of Oncology,Chemotherapy Near the End of Life: What Factors Matter?,"What patient-, tumor-, and facility-related factors are associated with chemotherapy use during the last month of life?"
  June 2017 ,Alimentary Pharmacology & Therapeutics,Impact of DAAs on Hepatitis C Antiviral Treatment in the VA,The results of this study indicate that the introduction of direct antiviral agents has dramatically transformed treatment and cure rates in the US Veterans Affairs national healthcare system.
  June 2017 ,Journal of the National Cancer Institute,Oophorectomy and Breast Cancer Risk in BRCA Carriers,Is breast cancer risk reduced in all women with BRCA mutations after preventive oophorectomy?
  June 2017 ,Morbidity & Mortality Weekly Report,Update on Use of MenB-FHbp Serogroup B Meningococcal Vaccine,"Two serogroup B meningococcal vaccines are currently licensed in the US for use in persons aged 10-25 years. Are they equivalent, and what are the current ACIP recommendations as to their use?"
  June 2017 ,European Heart Journal,Redefining Blood Pressure Targets,"Why do blood pressure targets continue to be contentious? In this commentary, the authors recommend an alternative to the search for 'the right number' for a BP target."
  June 2017 ,Human Reproduction,Euploidy Rates in Donor Egg Cycles,"This study suggests that embryonic chromosome abnormalities may be partly iatrogenic, differing among assisted reproduction centers."
  July 2017 ,Urologic Nursing,Recognition and Management of Rare Kidney Stone Disorders,The early diagnosis and prompt treatment of rare stone disorders will help optimize outcomes and prevent long-term complications.
  July 2017 ,Journal of the Endocrine Society,A Bizarre Case of Graves Disease Due to Vitamin Treatment,"This unusual case highlights how biotin intake may influence thyroid function immunoassays, leading to misdiagnosis."
  July 2017 ,Journal of Clinical Endocrinology & Metabolism,Piloting a Remission Strategy in Type 2 Diabetes,How effective are interventions targeting remission of type 2 diabetes?
  July 2017 ,Nephrology Dialysis Transplantation,Glycemic Control in Those With Diabetes and Kidney Disease,What are the best approaches to glycemic management among frail older patients with diabetes and chronic kidney disease?
  July 2017 ,Southern Medical Journal,Pirfenidone and Nintedanib for Idiopathic Pulmonary Fibrosis,"Until recently, there was no effective treatment for idiopathic pulmonary fibrosis, but two new agents were approved in 2014. How do these drugs impact outcomes in this often-fatal disease?"
  July 2017 ,Journal of Viral Hepatitis,Chronic Hepatitis C and Chronic Kidney Disease,"Patients with chronic HCV and concomitant chronic kidney disease have historically had few treatment options, but new antiviral therapies have the potential to improve outcomes."
  July 2017 ,Cancer Control: Journal of the Moffitt Cancer Center,Disparities in Adolescents and Young Adults With Cancer,Unmet needs of adolescents and young adults with cancer may be contributing to poor outcomes.
  July 2017 ,Clinical Gastroenterology and Hepatology,Screening and Colorectal Cancer Among Individuals 50 or Older,Can the decrease in colorectal cancer incidence among adults age 50 or older be attributed to increased screening?
  July 2017 ,Europace,Smart Detection of Atrial Fibrillation,This study evaluated the feasibility of a novel smartphone app which utilizes photoplethysmographic pulse wave signals from the phone camera for detecting atrial fibrillation.
  June 2017 ,Annals of Oncology,Is Simplicity Compatible With Precision Medicine?,Why hasn't increased knowledge on genomics led to a proportional increase in the approval of novel targeted therapies?
  June 2017 ,Clinical Endocrinology,Impaired QoL in Patients With Treated Acromegaly,Find out which factors may negatively impact quality of life among patients with treated and controlled acromegaly.
  June 2017 ,Stroke,Dietary Protein Intake and Stroke Risk in Japan,Does dietary protein intake have an impact on stroke risk? This study examined the influence of both vegetable and animal protein sources.
  June 2017 ,Headache,Sumatriptan Nasal Powder vs Oral Sumatriptan for Migraine,"A new formulation of sumatriptan with a novel delivery system, sumatriptan nasal powder, was recently approved for acute treatment of migraine with or without aura. How does it compare?"
  June 2017 ,Current Opinion in Rheumatology,The Field of Spondyloarthritis Coming of Age,What progress has been made in our current understanding of spondyloarthritis -- and where do we go from here?
  June 2017 ,Alimentary Pharmacology & Therapeutics,Quality of Trials on the Effects of a Low FODMAP Diet for IBS,"The low FODMAP diet is a popular recommendation for IBS patients, but does the quality of the evidence support its use?"
  June 2017 ,Spine,Comparison of Techniques for Cervical Spondylotic Myelopathy,How do these techniques for the surgical management of four-level cervical spondylotic myelopathy compare in terms of outcomes and complications?
  June 2017 ,Pain Management Nursing,A Guided Internet-Based Intervention for Chronic Pain,"The authors describe a novel, internet-based intervention for chronic pain sufferers that includes self-management and cognitive behavioral therapy."
  June 2017 ,Preventing Chronic Disease,CDC's Public Health Surveillance of Cancer,Learn how CDC approaches cancer surveillance by way of their public health programs and federal initiatives which monitor cancer-related outcomes. How is this valuable data being used?
  June 2017 ,Rheumatology,Monotherapy With Biologic DMARDs in Rheumatoid Arthritis,Biologic DMARD monotherapy may be a viable treatment alternative for patients with rheumatoid arthritis when combination therapy is not an option.
  June 2017 ,Annals of Oncology,Next Steps in Immuno-Oncology: Enhancing Antitumor Effects,Is dual immune checkpoint blockade synergistic and safe? Find the latest research here.
  July 2017 ,Alimentary Pharmacology & Therapeutics,The Safety of Vedolizumab for the Treatment of IBD,This review assesses the safety of vedolizumab for the treatment of IBD. Has post-marketing data raised any safety concerns that differ from the original trials?
  July 2017 ,HIV Medicine,A Clinical Decision Support System Prompting HIV Testing,Could this new clinical decision support application to prompt testing help increase the identification of undiagnosed HIV infection?
  July 2017 ,Circulation,Is Cardioprotection Dead?,"Despite failure to date of cardioprotective strategies to mitigate post-MI cardiac injury, cellular postconditioning provides new hope that myocardial reperfusion injury can be effectively targeted."
  July 2017 ,European Heart Journal,Should We Reconsider the Role of Age in Prevention of CVD?,The author examines how age has factored into risk-based prevention strategy for cardiovascular disease--specifically the initiation of statin therapy. Do we need to change our approach?
  July 2017 ,Journal of the American Geriatrics Society,Statins and Response to Vitamin D Treatment in Older Adults,Does statin use alter response to vitamin D treatment in older adults?
  July 2017 ,Journal of the National Cancer Institute,Gene Score for Recurrence Risk in ER-Positive Breast Cancer,Can this gene recurrence score help determine which patients with ER-positive breast cancer are good candidates for radiotherapy after adjuvant chemotherapy plus tamoxifen?
  July 2017 ,Alimentary Pharmacology & Therapeutics,Tenofovir to Prevent Mother-to-child Transmission of HBV,Is tenofovir safe and tolerable for both the mother and fetus when administered to pregnant women with chronic HBV infection?
  July 2017 ,Urologic Nursing,The Role of the Female Urinary Microbiota in OAB Symptoms,New research suggests a possible link between the microbiota of the female urinary tract and overactive bladder symptoms. What are the implications for urine culturing practices?
  July 2017 ,Journal of Viral Hepatitis,DAAs for HCV in Patients With Severe Renal Impairment,Can direct-acting antivirals be used safely for treating hepatitis C virus infection in patients with severe renal impairment?
  July 2017 ,Spine,Intrathecal Morphine in Spine Surgery,Is intrathecal morphine an effective choice for pain control after spine surgery?
  July 2017 ,American Journal of Kidney Diseases,Kidney Disease and the Westernization of Food,Has the Western diet played a role in the incidence and progression of kidney diseases?
  July 2017 ,European Heart Journal,Blood Pressure Targets,"To what extent are the SPRINT findings relevant to clinical practice? In this commentary, the authors discuss and appraise this landmark trial."
  July 2017 ,Annals of Oncology,Identifying and Interpreting Actionable Genetic Mutations,These databases can help you navigate the vast amount of information available on actionable mutations.
  July 2017 ,Stroke,Isolated Atypical Transient Symptoms in a Cohort With TIA,"Isolated atypical transient symptoms, such as partial sensory deficit, vertigo, visual deficit, or diplopia can be associated with many diagnoses. How often do they indicate transient ischemic attack?"
  July 2017 ,Journal of the National Cancer Institute,Vitamin B6 and Cancer Risk: Field Synopsis and Meta-analysis,What role does vitamin B6 have in carcinogenesis? Can supplementation reduce risk?
  July 2017 ,Alimentary Pharmacology & Therapeutics,Alginate-antacid With PPI for Breakthrough Symptoms,Is the alginate-antacid Gaviscon a useful adjunct to PPI therapy in patients who have unresolved symptoms?
  July 2017 ,Brain,Microglia and Macrophages: Targets for Glioblastoma Therapy,"This review explores the role of glioblastoma-associated microglia and macrophages in tumor biology, and their promise as potential immunotherapeutic targets for this fatal disease."
  July 2017 ,American Journal of Epidemiology,"ART, Depression, and Mortality Among HIV-Infected Women","This study examines the complex inter-relationship between antiretroviral therapy, mortality, and depression in women with HIV."
  July 2017 ,Annals of Oncology,Predicting Response to Anti-PD1 Antibodies in Melanoma,Research finds that circulating tumor DNA may help predict overall survival in patients with metastatic melanoma.
  July 2017 ,BMC Oral Health,Chlorhexidine Gel for Prevention of Alveolar Osteitis,Alveolar osteitis is a very painful complication of tooth extraction. Might application of chlorhexidine gel reduce its incidence?
  August 2017 ,Journal of the American Geriatrics Society,PPI Usage and Risk of Pneumonia in Dementia Patients,Does PPI usage increase the risk of pneumonia in dementia patients?
  August 2017 ,BMC Pulmonary Medicine,What Patients Really Think About Asthma Guidelines,Which factors may hinder a patient's compliance with currently recommended treatment and management strategies for asthma -- and how can clinicians help them overcome these barriers?
  August 2017 ,American Journal of Cardiovascular Drugs,Management of Heart Failure With Preserved Ejection Fraction,"This article presents a summary of traditional as well as emerging pharmacotherapies for heart failure with preserved ejection fraction, the most common form of HF in the elderly."
  August 2017 ,American Journal of Clinical Dermatology,Oral Antibacterial Therapy for Acne Vulgaris,What is the evidence for the efficacy of oral antibiotics for acne? This review examines different antibiotic classes and regimens and compares their potential side effects and long-term impact.
  August 2017 ,Liver International,DAA Combination for Elderly Patients With Chronic Hepatitis C,This study aimed to assess the cost-effectiveness of direct-acting antivirals for the treatment of chronic hepatitis C in elderly patients. Which patients should be considered for treatment?
  August 2017 ,Journal of Viral Hepatitis,Assessment of Liver Fibrosis in Patients With Chronic HBV,The authors compared the diagnostic performance of several biomarkers for the assessment of liver fibrosis in patients with chronic HBV infection.
  August 2017 ,Cancer Control: Journal of the Moffitt Cancer Center,Trial Enrollment Barriers in Minority Patients With Cancer,"To improve enrollment of a diverse population into clinical trials, researchers have developed an evidence-based intervention addressing barriers at individual and interpersonal levels."
  August 2017 ,Annals of Oncology,Examination of CTC Profiles in NSCLC Molecular Subgroups,What number of circulating tumor cells is associated with a poor prognosis in advanced NSCLC?
  August 2017 ,Skin Therapy Letter,Secukinumab for Psoriasis and Psoriatic Arthritis,"This article reviews phase II and phase III clinical trials for secukinumab, an IL-17A inhibitor which presents a promising new treatment approach for refractory psoriasis and psoriatic arthritis."
  August 2017 ,European Heart Journal,Reversal Strategies for Non-vitamin K Antagonist OACs,What are the current best options for the reversal of the effects of NOACs due to an emergency situation?
  August 2017 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Impact of Early ART on HIV Rapid Tests and Incidence Assays,In what ways might the early initiation of ART affect HIV diagnostic and incidence assay results?
  August 2017 ,BMC Anesthesiology,An Endoscopic Mask for Fiberoptic Bronchoscopic Intubation,A novel endoscopic mask may be helpful for preventing hypoxia during awake fiberoptic intubation.
  August 2017 ,The British Journal of Dermatology,EBM for Atopic Eczema: Identifying the Knowns and Unknowns,What is the current state of knowledge concerning effective and ineffective treatments for atopic eczema? A new scoping review tackles the task of summarizing what we know and identifying gaps.
  August 2017 ,Morbidity & Mortality Weekly Report,High Risk for Invasive Meningococcal Disease With Eculizumab,This report details the increased risk for serious meningococcal disease in patients receiving eculizumab for treatment of paroxysmal nocturnal hemoglobinuria or atypical hemolytic uremic syndrome.
  August 2017 ,AIDS,Monoclonal Antibodies to Prevent Sexual Transmission of HIV,"Human monoclonal antibodies are being investigated as an exciting new option for the prevention of HIV transmission, but further research is needed."
  August 2017 ,Annals of Oncology,What Treatment in 2017 for Inoperable Pancreatic Cancers?,Read this to find current standards of care for locally advanced and metastatic pancreatic cancers.
  July 2017 ,Translational Andrology and Urology,Sexual Dysfunction Due to Pharmacological Therapy of BPH,Sexual dysfunction can be a side effect associated with medications used to treat BPH. How is it best managed?
  July 2017 ,European Heart Journal,Improving Clinical Trial Guidelines and Their Application,What steps should be taken to produce meaningful change in the conduct of cardiovascular clinical research? Read the conclusions of a recent roundtable of the European Society of Cardiology.
  July 2017 ,European Heart Journal,Lipoprotein(a): The Revenant,This review examines the current research on lipoprotein(a) as a cardiovascular risk factor and a potential target in the management of dyslipidemia.
  July 2017 ,Anesthesiology,Phrenic Nerve Palsy and Anesthesia for Shoulder Surgery,"Phrenic nerve palsy is a complication of the most common regional anesthetic technique for shoulder surgery, especially in patients at high-risk of respiratory complications. Can the risk be reduced?"
  October 2017 ,Current Opinion in Rheumatology,Intestinal Microbiome in Scleroderma,How has our understanding of the involvement of intestinal microbiome in scleroderma recently evolved?
  October 2017 ,Menopause,Validity of Two Hot Flash-related Daily Interference Scales,This study assessed the validity of a condensed version of a 10-item psychometric self-report questionnaire for assessing the impact of hot flashes on a woman's quality of life.
  October 2017 ,Current Opinion in Urology,Obesity and Prostate Cancer,Might obesity contribute to the development and progression of prostate cancer? A new review investigates.
  October 2017 ,Arthritis Research & Therapy,Incident Gout and Erectile Dysfunction,What is the relationship between gout and ED -- and where does hyperuricemia fit in the equation?
  October 2017 ,Clinical Gastroenterology and Hepatology,Continuous Clinical Response in Ulcerative Colitis,Continuous clinical response has emerged as a useful target in the management of ulcerative colitis. Can it be feasibly integrated into clinical practice as a patient-reported outcome?
  October 2017 ,The Gerontologist,Reducing Resistiveness in Dementia Care,"A large percentage of patients with dementia exhibit physical or verbal aggression or agitation, and resistance to care. Can a brief intervention that reduces staff 'elderspeak' help?"
  October 2017 ,Liver International,Outcomes After Curative Treatments of HCV-Related HCC,What does the available evidence tell us about the recurrence and survival rates of HCV-related hepatocellular carcinoma after curative resection or ablation?
  September 2017 ,Critical Care,Ultrasound-Guided Central Venous Catheter Placement,What are the latest recommendations for the use of ultrasound during central venous catheter placement?
  September 2017 ,Brain,Neuroprotection in Stroke: Collaboration and Reproducibility,What are the challenges faced by translational stroke research? This articles focuses on the need to bridge the gap between current preclinical approaches and clinical trials of stroke therapy.
  September 2017 ,Journal of Medical Case Reports,How to Choose the Best Journal for Your Case Report,"With the proliferation of open access journals, selecting one that is reputable has become more difficult--and confusing. This article offers guidelines to help weed out the controversial ones."
  September 2017 ,Circulation,Reverse Causality in Cardiovascular Epidemiological Research,Are instances of reverse causality muddying findings in cardiovascular research? A new study reminds us that many potential biases should be borne in mind in epidemiological analyses.
  September 2017 ,Age and Ageing,Is Orthostatic Hypotension Related to Falling?,"The association of orthostatic hypotension with falls has been widely debated due to conflicting evidence, but this novel study using individual patient data meta-analysis provides new insights."
  September 2017 ,Nephrology Dialysis Transplantation,High-Protein Meals and Lanthanum Carbonate in Hemodialysis,What benefits might an increased protein intake combined with lanthanum carbonate offer hemodialysis patients?
  September 2017 ,Brain,CV Abnormalities in Alzheimer's: A Treatment Target?,"A new study highlights the potential importance of changes in cerebrovascular resistance early in the course of Alzheimer's disease, and may open the door to a potential treatment target."
  September 2017 ,Endocrine Practice,SGLT2 and DPP-4 Inhibition,What role could combination therapy with these inhibitors play in the management of type 2 diabetes?
  August 2017 ,Journal of Viral Hepatitis,HBV Reactivation in Breast Cancer Patients on Chemotherapy,"Sometimes fatal HBV reactivation may occur in patients with breast cancer receiving chemotherapy. What factors might identify patients at risk, and how should they be managed?"
  August 2017 ,Journal of Clinical Endocrinology & Metabolism,Statin Therapy Reduces Amputation Risk in Diabetes and PAD,Statin use may help protect against the risk of lower-extremity amputation among patients with type 2 diabetes and peripheral artery disease.
  August 2017 ,American Family Physician,Top POEMs Consistent With Principles of Choosing Wisely,"By analyzing Daily POEMs that are most consistent with principles of the Choosing Wisely campaign, this study sought to identify low-value clinical actions supported by high-quality evidence."
  August 2017 ,The British Journal of Dermatology,Long-term Adherence to Topical Psoriasis Treatment,"While psoriasis is a chronic disease requiring long-term treatment adherence, this study finds that many patients are falling short."
  August 2017 ,Alimentary Pharmacology & Therapeutics,Clinical Decision-making in Severe Alcoholic Hepatitis,Management of patients with alcoholic hepatitis remains controversial. How have recent studies informed our clinical decision-making for these patients?
  December 2017 ,Chinese Clinical Oncology,Immune Checkpoint Inhibitors in Lung Cancer,"The PD-1, PD-L1, and CTLA-4 inhibitors show promise in lung cancer, but questions about biomarker use and place in therapy need to be resolved."
  December 2017 ,Journal of the American Geriatrics Society,The Effect of Low Vitamin D on Cognition,Might vitamin D protect against cognitive decline and dementia in aging?
  December 2017 ,Alimentary Pharmacology & Therapeutics,Anti-TNF Treatment in Crohn's Disease and Bowel Resection Risk,"TNF inhibitors have been shown to reduce the need for surgery in Crohn's disease, but does that benefit persist after the first year?"
  December 2017 ,Pediatric Pharmacotherapy,Extended-Release Methylphenidate Oral Tablets,A newly approved extended-release formulation of methylphenidate may be another option for the management of ADHD in children.
  December 2017 ,Journal of the American Geriatrics Society,Focus on Neuropsychiatric Symptoms in Alzheimer's Research,Has research on Alzheimer disease short-changed the importance of neuropsychiatric symptoms--often the most debilitating and challenging manifestations of dementia?
  December 2017 ,Journal of Clinical Oncology,Naldemedine for Opioid-Induced Constipation,This peripherally-acting mu-opioid receptor antagonist is showing promise in patients with cancer and opioid-induced constipation.
  December 2017 ,American Journal of Pharmaceutical Education,Integrating Biosimilars Into the PharmD Curriculum,What do PharmD students need to know about biosimilars? This article provides an initial framework by which pharmacy schools can incorporate biosimilars and related content into the curriculum.
  November 2017 ,Annals of Family Medicine,Are Clinical Practice Guidelines Moving Us Forward or Backward?,"In this commentary, the author argues for more uniformly rigorous clinical practice guideline development, along with substantial and transparent funding for such efforts."
  November 2017 ,Journal of the American Geriatrics Society,PPIs and Risk of Mild Cognitive Impairment and Dementia,"A new study allays concern about the safety of PPIs with respect to cognitive function, including increased risk of dementia and Alzheimer's disease--in contrast to prior reports."
  November 2017 ,Alimentary Pharmacology & Therapeutics,Fecal Microbiota Transplant for Refractory C. Difficile,This meta-analysis aimed to systematically evaluate the effectiveness of fecal microbiota transplantation as treatment for recurrent and refractory C. difficile infection.
  November 2017 ,BMC Anesthesiology,Considerations & Complications After Administering Sugammadex,"While sugammadex has dramatically changed clinical practice of neuromuscular reversal, it also presents new challenges and potential complications. What do you need to know?"
  November 2017 ,Alimentary Pharmacology & Therapeutics,New Treatments in Non-alcoholic Fatty Liver Disease,An improved understanding of the mechanisms behind NAFLD has led to new approaches to pharmacotherapy. This review presents an overview of current and investigational therapeutics.
  November 2017 ,The British Journal of Dermatology,Biosimilars for Psoriasis: Determining Similarity,"In this review, the International Psoriasis Council explains how biosimilars are evaluated in a clinical setting."
  November 2017 ,The British Journal of Dermatology,Antipruritic Effect of Pretreatment With Topical Capsaicin,Is high-concentration topical capsaicin an effective treatment for histaminergic and nonhistaminergic itch?
  November 2017 ,Current Opinion in Urology,Immunotherapy for Metastatic Prostate Cancer,This review explores the promising new role of immunotherapy in the treatment of metastatic castration-resistant prostate cancer.
  November 2017 ,Journal of Viral Hepatitis,Shortening Duration of Therapy With DAAs for HCV Genotype 1,Can direct-acting antiviral therapy for hepatitis C genotype 1 be reduced to less than the current standard of 12 weeks without compromising outcomes?
  November 2017 ,Circulation,Maximizing CV Event Reduction by Expanding the Targets,"In this commentary, the author presents the case for lowering hypertension targets, and laments the slow pace by which more aggressive guidelines are being adopted in the US."
  October 2017 ,The Journal of Emergency Medicine,Access to Care and Depression Among ED Patients,Do ED patients presenting with symptoms of depression have access to appropriate mental health care?
  October 2017 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Safety of TDF-Based ART in Pregnant Women and Their Infants,A review examines the question of whether any adverse effects are associated with the use of TDF-based ART during pregnancy.
  October 2017 ,Journal of the American Board of Family Medicine,Patient-Entered Wellness Data Increases Preventive Care,A new tool collects patient-entered data and provides personalized preventive care recommendations in several wellness areas.
  December 2017 ,Headache,Fremanezumab as Add-On With Other Migraine Preventives,This study evaluated the efficacy and safety of fremanezumab as an add-on preventive therapy in individuals with episodic and chronic migraine who are taking other preventive migraine medications.
  December 2017 ,American Journal of Clinical Dermatology,Vitiligo: An Update on Pathophysiology and Treatment Options,Recent research has provided insights into the pathogenesis of both nonsegmental and segmental vitiligo. Review their differing etiologies and promising new treatments in this comprehensive primer.
" Open Access Journal of Plastic Surgery,  December 2017 ",ePlasty,Safe Plastic Surgery of the Breast: Saving Nipple Sensation,Find out about the 'unsafe zone' of the breast that should be avoided during reduction mammoplasty to preserve nipple sensation.
  December 2017 ,Nephrology Dialysis Transplantation,AKI Ascertainment for Clinical and Preclinical Studies,How do clinical and preclinical interventional studies differ in their use of acute kidney injury biomarkers?
  December 2017 ,Spine,Lower Limbs Compensation in Sagittal Malalignment,A new study evaluates the relationship between lower limb compensatory mechanisms and progressive sagittal malalignment.
  December 2017 ,Rheumatology,The Role of Female Hormonal Factors in the Development of RA,In what ways might female hormonal factors contribute to the development of rheumatoid arthritis?
  December 2017 ,Chinese Clinical Oncology,Immunotherapy Combinations for Pancreatic Cancer,Can resistance of pancreatic cancer to immunotherapy be overcome using combinations?
  December 2017 ,Journal of the American Board of Family Medicine,Text Messaging to Improve Adherence to Lipid Testing,Is two-way text messaging a feasible and acceptable form of communication for test reminders?
  December 2017 ,American Journal of Clinical Pathology,Variability and Error in Cardiac Troponin Testing,"While cardiac troponin assays are reliable diagnostic tests for acute myocardial infarction, their implementation and interpretation are complex. Explore potential sources of error in this review."
  December 2017 ,Skin Therapy Letter,Dupilumab for Moderate-to-Severe Atopic Dermatitis,"Dupilumab, an IL-4 and IL-13 antagonist, was recently FDA approved for patients with moderate-to-severe atopic dermatitis. Will it be a game-changer in the management of this challenging condition?"
  December 2017 ,Journal of the American Geriatrics Society,Exclusion of the Elderly From RCTs of Drugs for Ischemic HD,Are the elderly being inadequately represented in randomized trials studying drug interventions for ischemic heart disease?
  December 2017 ,American Nurse Today,Genetics in the Clinical Setting,Find out about the role of genetics and genomics in the clinical setting -- and what nurses need to know.
  December 2017 ,Nephrology Dialysis Transplantation,"Uric Acid, Protein and Mortality in Hemodialysis Patients",What do we currently know about the association between uric acid concentrations and mortality in hemodialysis patients -- and how does protein intake fit into the equation?
  December 2017 ,Chinese Clinical Oncology,Next Generation Approaches for Tumor Vaccination,"While early studies were disappointing, cancer vaccines are making a resurgence due to advances in precision medicine."
  December 2017 ,Journal of the American Geriatrics Society,The Clinical Potential of Senolytic Drugs,"Could senolytic drugs, which target fundamental aging processes, be the answer to combating the multiple chronic diseases associated with aging?"
  December 2017 ,Spine,Predictors of Treatment Outcome in Sacroiliac Joint Pain,Could certain factors predict treatment outcomes among patients treated for sacroiliac joint pain?
  December 2017 ,Journal of Viral Hepatitis,Increasing HCV/HBV Diagnosis in Urban Health Clinics,"This report details the use of a kiosk-based, audio-computer-assisted interview platform for identifying patients at risk for HCV or HBV infection or in need of HBV vaccination."
  December 2017 ,Europace,Designing an Optimal Screening Program for Unknown AF,At which age should screening for atrial fibrillation be initiated? This study used computer simulations to determine an optimal age and evaluate the value of repeated screenings.
  December 2017 ,European Heart Journal,Stem Cell Therapy: Translational Hurdles to New Frontiers,This brief commentary summarizes recent developments in the use of stem cells and regenerative therapy in cardiovascular diseases.
  December 2017 ,American Journal of Epidemiology,Challenges and New Opportunities for GxE Interaction Studies,How does the interaction of genes and environment contribute to our understanding of disease in the human population? Read about the emerging field of gene-environment interaction (GxE) in this review.
  January 2018 ,The British Journal of Dermatology,Guidelines for the Management of Pemphigus Vulgaris 2017,"The British Association of Dermatologists presents updated, evidence-based guidelines for the management of pemphigus vulgaris, with recommendations for practical use in the clinic."
  January 2018 ,Circulation,Are Meta-analyses a Form of Medical Fake News?,The author of this commentary questions the value of meta-analyses. Do they really contribute anything new?
  January 2018 ,Journal of Clinical Rheumatology,Interventions for Depression and Anxiety in Persons With RA,"How are depression and anxiety treated in patients with rheumatoid arthritis, and how effective are the interventions?"
  January 2018 ,Current Opinion in Psychiatry,Smart Phone Technology for Depression Management and Research,M-health: is it just hype or of real value in psychiatry? This review examines the future potential of smartphone technology in the assessment and treatment of depression.
  January 2018 ,Alimentary Pharmacology & Therapeutics,Therapeutic Drug Monitoring of Anti-TNF Therapy in IBD,The authors present multiple consensus statements which support and detail the role of therapeutic drug monitoring in optimizing the use of anti-TNF agents in modern IBD management.
  January 2018 ,Journal of the American Board of Family Medicine,A Standardized Medication Therapy Management Plus Approach,"This study investigated the feasibility of an enhanced, clinical pharmacist-led medication therapy management service in the primary care setting."
  January 2018 ,American Journal of Clinical Pathology,SHG Reveals Subtle Differences in Adult and Pediatric NAFLD,A novel imaging system can reveal subtle differences in pediatric and adult patterns of steatofibrosis not captured by other methods.
  January 2018 ,Morbidity & Mortality Weekly Report,National ALS Registry: Impact and Future Directions,"Learn about the National ALS Registry, launched in 2010, which was created to describe the incidence and demographics of persons with ALS and examine the etiology and risk factors for the disease."
  January 2018 ,Chinese Clinical Oncology,An Update on Radiation Therapy for Brain Metastases,Recent advances in radiotherapy for brain metastases are preserving neurocognitive function without compromising survival.
  January 2018 ,Current Opinion in Allergy and Clinical Immunology,Whole Exome Sequencing in Inborn Errors of Immunity,"Whole exome sequencing could play an exciting new role in the diagnosis of inborn errors of immunity, but there are limitations."
  January 2018 ,Liver International,"Gender, Menopausal Status, and Drug-induced Liver Injury",How might gender and sex hormones contribute to type and severity of drug-induced liver injury?
  January 2018 ,Annals of Oncology,Treating Cancer Cachexia: An Evolving Landscape,"While the ghrelin agonist, anamorelin, shows promise for cancer cachexia, approval of any agent for this condition is challenging."
  January 2018 ,Translational Lung Cancer Research,Immunotherapy for Malignant Pleural Mesothelioma,"Review checkpoint blockade, immunotoxin, oncolytic viral, and adoptive cell therapies for malignant mesothelioma."
  January 2018 ,Liver International,Biomarkers for Drug-induced Liver Injury,"This review examines the potential use of both traditional and new candidate biomarkers for prediction, detection, and risk management of drug-induced liver injury."
  January 2018 ,Journal of the American Board of Family Medicine,What Makes for Successful Registry Implementation,What factors--and in what combination--are necessary for successful implementation of a patient registry for a patient-centered medical home?
  January 2018 ,Spine,Pedicle Screw Safety: How Much Anterior Breach Is Safe?,What are the safety limits of a misplaced pedicle screw?
  January 2018 ,Chinese Clinical Oncology,Adjuvant and Neoadjuvant Therapy for Pancreatic Cancer,Ongoing clinical trials are evaluating aggressive chemotherapy regimens and radiotherapy in pancreatic cancer.
  December 2017 ,Journal of Viral Hepatitis,HBV Reactivation Risk With DAA Therapies vs. Interferon for HCV,Do direct-acting antiviral-based therapies for HCV have more potential to cause frequent HBV reactivation compared with interferon-based therapies?
  December 2017 ,Menopause,"Stress Eating, Menopause, Depression and Weight in Midlife",What mechanisms might contribute to weight gain in midlife women? This study investigated stress eating and menopause status as a potential link between depression and weight gain in this group.
  December 2017 ,European Heart Journal,Clopidogrel After 1 Month in Stabilized ACS Patients,A new study investigates switching from prasugrel or ticagrelor to clopidogrel vs. continuing either drug after a PCI for ACS. Will the results change clinical practice?
  February 2018 ,The British Journal of Dermatology,A Holistic Care Approach to Malignant Melanoma,"In this editorial, the author underscores the need for a multidisciplinary, collaborative approach to treatment of malignant melanoma, uniting dermatologists, oncologists and researchers."
  February 2018 ,Journal of the National Cancer Institute,Supplements and Chemotherapy-Induced Peripheral Neuropathy,Do multivitamins mitigate development of chemotherapy-induced peripheral neuropathy?
  February 2018 ,Journal of Cardiovascular Electrophysiology,SCD in Nonischemic Cardiomyopathy: Assessing Risk,"The authors suggest improvements to risk stratification among patients with nonischemic causes of cardioymopathy, focusing on the importance of etiology and identification of myocardial scarring."
  February 2018 ,Journal of the Endocrine Society,Sugar-Sweetened Beverages and Cardiometabolic Diseases,Could the frequent intake of sugar-sweetened beverages contribute to the development of cardiometabolic diseases?
  February 2018 ,American Journal of Cardiovascular Drugs,Benefit-Risk Assessment of Crataegus Extract WS 1442,Crataegus--commonly known as hawthorn--has long been used in the treatment of heart failure. Might it be a safe and effective adjunct in current clinical practice?
  February 2018 ,Seminars in Neurology,Magnetic Resonance Spectroscopy as a Biomarker for CTE,"Currently, chronic traumatic encephalopathy can only be definitively diagnosed postmortem. How might magnetic resonance spectroscopy be used to determine a probable CTE diagnosis in living patients?"
  February 2018 ,Annals of Oncology,Predictors of Paclitaxel Neurotoxicity,A new study finds discordance between patient- and clinician-reported neurotoxicity associated with paclitaxel.
  February 2018 ,BMC Oral Health,A Fluorescent Imaging System for Detection of Dental Plaque,"The authors developed a cost-effective device for rapid screening of plaque and plaque severity which can easily be used at the clinic, at home, or by primary care physicians."
  January 2018 ,American Journal of Critical Care,Core Temperatures Measured With SpotOn Monitoring System,The SpotOn thermometry system may provide an effective new alternative for the monitoring of core body temperature in ICU patients.
  January 2018 ,Pain Management Nursing,Ketamine for Pain Management,"Ketamine is increasingly used as an off-label analgesic, but are you aware of the potential side effects?"
  January 2018 ,BMC Oral Health,Clinical Studies on Core-carrier Obturation,How does the success rate of endodontic treatment using core-carrier obturation compare with that of traditional cold lateral condensation?
  January 2018 ,HIV Medicine,PENTA Guidelines for Treatment of Pediatric HIV-1 Infection,This article provides an update to the PENTA recommendations for the management of HIV-1 infection in children.
  January 2018 ,Headache,CAM Use Among US Adults With Headache or Migraine,"How prevalent is the use of CAM among migraine and headache sufferers? Which modalities are used most often, and why are they selected?"
  January 2018 ,Chinese Clinical Oncology,Rational Combination of Immunotherapy for TNBC Treatment,Chemotherapeutic and targeted agents may enhance anti-tumor immunity against TNBC by reducing PD-L1 expression.
  January 2018 ,Cancer Control: Journal of the Moffitt Cancer Center,Experimental Treatments for Leptomeningeal Metastases,Novel agents that penetrate the blood-brain barrier offer new hope for effective management of leptomeningeal metastases.
  January 2018 ,Journal of the American Geriatrics Society,Treatment Effectiveness in HF With Lung or Kidney Disease,This study assessed the clinical effectiveness of treatment of heart failure in the setting of two common comorbidities: chronic lung disease and chronic kidney disease.
  January 2018 ,Skin Therapy Letter,Azelaic Acid 15% Gel for the Reduction of Rosacea Lesions,"A recent trial assessed the effects of azelaic acid 15% gel on inflammatory lesions of papulopustular rosacea in a real-world setting, with promising results."
  January 2018 ,Annals of Oncology,Immune-Related Adverse Events of Checkpoint Inhibitors,Monoclonal antibodies targeting CTLA-4 and PD-1 have immune-related adverse events that are quite different with regards to drug class and tumor type.
  January 2018 ,BMC Oral Health,Creating R&D Awareness Among Dental Care Professionals,How can we encourage awareness and interest in current clinical research among dental care professionals? This study evaluated the influence of a strategic communication plan on R&D awareness.
  January 2018 ,Breast Cancer Research,Proteomic Profiling of Breast Cancer Metabolism,What is the relationship between metabolism-associated proteins and survival in patients with breast cancer?
  February 2018 ,Brain,Spread of Tau Deposits: Can We Trust In Vivo Findings?,This commentary discusses the huge potential of in vivo tau PET imaging for early diagnosis of Alzheimer disease--while underscoring potential challenges in interpretation and implementation.
  February 2018 ,BMC Oral Health,Intraoral Scanners in Dentistry,"What are the advantages and disadvantages of using optical impressions in dentistry, compared to conventional impressions? This review examines the applications and limitations of this technology."
  February 2018 ,Annals of Surgery,Magnetic Surgery: First Prospective Clinical Trial Results,Find out about the exciting new role a novel magnetic surgical system could have in laparoscopic cholecystectomy.
  February 2018 ,Morbidity & Mortality Weekly Report,Recommendations of the ACIP for Use of Herpes Zoster Vaccines,"This report updates recommendations for herpes zoster vaccine in light of the newly approved recombinant Zoster Vaccine, Shingrix."
  February 2018 ,European Heart Journal,Renal Denervation: Will the Phoenix Rise From the Ashes?,"A prior disappointing study seemed to close the book on renal denervation for resistant hypertension, but results of a new clinical trial give renewed, if cautious, optimism for this approach."
  February 2018 ,BMC Anesthesiology,McGrath MAC Laryngoscope for Routine Nasotracheal Intubation,How does the McGrath MAC video laryngoscope compare with the Airway Scope and Macintosh laryngoscope for routine nasotracheal intubation?
  February 2018 ,Journal of the American Geriatrics Society,Medications That Cause Dry Mouth in Older People,"Xerostomia, or dry mouth, is one of the most common adverse effects of medication use in older adults. Which classes of drugs are most problematic, and how great is the risk?"
  February 2018 ,The British Journal of Dermatology,Progress in the Diagnosis and Therapy of Melanoma,This brief report summarizes some of the most pivotal epidemiological and clinical studies on melanoma published in the British Journal of Dermatology in recent years.
  February 2018 ,Spine,Changes in Cervical Alignment After Multilevel Osteotomies,A new study examines the reciprocal cervical changes among adult spinal deformity patients undergoing multilevel Schwab Grade II osteotomies.
  February 2018 ,Current Opinion in Urology,Prostate Cancer Immunotherapy,Find out more about the current landscape for prostate cancer immunotherapy and learn about potential treatment strategies.
  February 2018 ,Journal for Nurse Practitioners,Telehealth and Legal Implications for Nurse Practitioners,What potential legal issues associated with telehealth should nurse practitioners be aware of?
  February 2018 ,Anesthesiology,Gabapentin and Postop Delirium in Older Surgical Patients,"What impact does the perioperative administration of gabapentin have on reduction of postoperative pain, opioid use, and delirium in surgical patients over 65?"
  February 2018 ,Menopause,Laser vs. Topical Estriol for Postmenopausal Vaginal Atrophy,Fractional CO2 laser treatment has emerged as an alternative treatment option for the management of vulvovaginal symptoms in postmenopausal women. How does it compare with topical estrogen therapy?
  February 2018 ,Annals of Oncology,Depth of Response in NSCLC with Targeted or Immunotherapies,Greater depth of response may be associated with overall survival and progression-free survival and could be considered as an additional outcome measure for clinical trials.
  February 2018 ,Wounds,Larval Therapy for Chronic Cutaneous Ulcers,"Larval debridement has been historically used in the management of chronic ulcers, but does it still have a place in modern wound healing?"
  February 2018 ,Anesthesia & Analgesia,Guidelines for Anticoagulation During Cardiopulmonary Bypass,New guidelines which detail the optimal management of anticoagulation during the conduct of cardiac surgery with cardiopulmonary bypass have been developed by an expert working group.
  February 2018 ,Journal of Clinical Oncology,Depth of Response in PETHEMA/GEM Myeloma Trials,"According to this research, minimal residual disease negativity should be considered one of the most relevant clinical endpoints for some populations of patients with MM."
  February 2018 ,Rheumatology,Adult Paget's Disease of Bone: A Review,A better understanding of the pathogenesis of Paget's disease of bone in adults will lead to improved diagnostic and treatment strategies for this metabolic bone disorder.
  February 2018 ,American Journal of Epidemiology,Long-term Effectiveness of the Live Zoster Vaccine,"A live attenuated zoster vaccine for the prevention of shingles has been licensed for older adults in the US since 2006. How effective has it been over the long-term, and does efficacy differ by age?"
  February 2018 ,Journal of Oncology Practice,Representation of Minorities and Women in Oncology Trials,Do clinical trials in oncology adequately represent the US population with cancer?
  March 2018 ,The British Journal of Dermatology,Advancing Pediatric Psoriasis Treatment Options for Children,"Up to half of cases of psoriasis start in childhood, and the incidence is on the rise. Are we doing enough to advance therapeutic options for children?"
  March 2018 ,U.S. Pharmacist,Review of Selected NMEs 2017,Learn about the profiles of recently approved new molecular entities in this review.
  March 2018 ,Arthritis Research & Therapy,Patient-Reported Outcomes of Baricitinib in Patients With RA,How did the use of baricitinib impact self-reported outcomes among patients with rheumatoid arthritis?
  March 2018 ,European Heart Journal,Antiplatelet Therapy in ACS Patients With Thrombocytopenia,"ACS patients with thrombocytopenia are at higher risk of both bleeding and ischemic events, making treatment particularly challenging. How should management be approached?"
  March 2018 ,HIV Medicine,B-Cell Activation and Dysfunction Preceding Lymphoma in HIV,In what ways might B-cell dysfunction and activation contribute to lymphoma development in HIV-positive persons?
  March 2018 ,Seminars in Neurology,A Personalized Treatment Approach to Women With Epilepsy,"Review the unique factors impacting epilepsy management in women, including interactions between antiepileptic drugs and hormonal contraception methods, and medication risks during pregnancy."
  March 2018 ,Journal of Clinical Endocrinology & Metabolism,Diabetic Microvascular Disease: Endocrine Society Statement,This scientific statement provides an updated summary and review of the pathogenesis and effects of diabetic microvascular disease.
  March 2018 ,Wounds,A Stool Management System for Fecal Incontinence Patients,A new study evaluates the safety and efficacy of a stool management system designed to manage fecal incontinence in bedridden patients.
  March 2018 ,Clinical Endocrinology,"Vitamin D and Calcium, Skeletal Muscle, and Testosterone",How might vitamin D and/or calcium supplementation affect skeletal muscle strength and serum testosterone in young adult males?
  March 2018 ,BMC Anesthesiology,Perioperative Hypoxemic Events in Patients With Sleep Apnea,Do anesthetic regimens need to be altered in patients with confirmed or suspected obstructive sleep apnea? This study compared two regimens generally considered suitable for OSA patients.
  February 2018 ,Translational Andrology and Urology,Biomarkers to Predict Treatment Response in Bladder Cancer,A new study looks at whether certain biomarkers may predict response to adjuvant and neoadjuvant treatments for bladder cancer.
  February 2018 ,Journal of the American Geriatrics Society,Cognitive Enhancers for Treating Alzheimer's Disease,This comprehensive meta-analysis reviewed 142 studies regarding the safety and efficacy of cognitive enhancers for Alzheimer disease. Which proved most effective?
  February 2018 ,HIV Medicine,Promoting High Standards of Care for Women Living With HIV,The Women Against Viruses in Europe Working Group released a position statement focused on improving issues in the management of women living with HIV.
  February 2018 ,Journal of the Endocrine Society,Dexcom G5 CGM System Trends to Manage Pediatric Diabetes,Using real-time continuous glucose monitoring trend arrow data to adjust insulin dosing can be a valuable tool in the management of pediatric diabetes.
  February 2018 ,Nephrology Dialysis Transplantation,Strategies to Manage Cardiovascular Risk in CKD,What are the best ways to address cardiovascular risk in patients with chronic kidney disease?
  February 2018 ,Annals of Oncology,Gemcitabine Plus Sirolimus for Osteosarcoma,The combination of gemcitabine and sirolimus may be a safe and effective option for patients with relapsed unresectable osteosarcoma.
  February 2018 ,Journal of Clinical Endocrinology & Metabolism,CDC73-Related Disorders in Primary Hyperparathyroidism,This article provides insight into the clinical manifestations of CDC73-related disorders and discusses ways to improve case detection in primary hyperparathyroidism.
  February 2018 ,Skin Therapy Letter,New Treatments for Hereditary Angioedema,"Review new developments in therapy for hereditary angioedema, including new C1 inhibitors, and the development of drugs that target the kallikrein-kinin pathway."
  February 2018 ,American Journal of Clinical Dermatology,First-Line Biologics for Moderate-to-Severe Psoriasis,"Multiple therapeutic options exist for moderate-to-severe psoriasis, each with unique benefits and limitations. This review offers guidance on choosing the optimal therapy for your patients."
  February 2018 ,Journal of the American Geriatrics Society,Hepatitis C Virus Clearance in Older Adults,Does HCV clearance with direct-acting antiviral therapy improve outcomes in individuals aged 80 and older--even in the face of severe liver disease and multiple comorbidities?
  March 2018 ,Breast Cancer Research,HER2 Is Not a Cancer Subtype but Rather a Pan-Cancer Event,Research in breast cancer genomics reveals the potential for combining anti-HER2 therapy with anti-androgen agents.
  March 2018 ,The British Journal of Dermatology,Infections From Ixekizumab in Patients With Psoriasis,"IL-17A antagonists are increasingly used to treat moderate-to-severe psoriasis, but infections are a concern. This study investigated the incidence and types of infections associated with ixekizumab."
  March 2018 ,Journal of Viral Hepatitis,Understanding and Addressing HCV Reinfection in the DAA Era,What factors are associated with HCV reinfection and how can reinfection risk be minimized?
  March 2018 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Prevention of HIV-1 Transmission Through Breastfeeding,"These strategies may help reduce mother-to-child transmission of HIV during breastfeeding, but how do they compare in terms of safety and efficacy?"
  March 2018 ,European Heart Journal,Variant of LILRB5 Is Associated With Statin Intolerance,"The authors identify a novel immunogenetic factor associated with statin intolerance, potentially opening the door for pre-treatment pharmacogenetic testing or diagnosis of statin-induced myopathy."
  March 2018 ,Alcohol and Alcoholism,Symptom-Triggered Detox Using the Alcohol-Withdrawal-Scale,This study assessed the effectiveness of symptom-triggered detoxification in a setting of a specialized treatment center for alcohol use disorder. Can it reduce use and dosage of benzodiazepines?
  March 2018 ,Wounds,Itching for Knowledge About Wound and Scar Pruritus,"When it comes to chronic itch and antipruritic therapies, what do wound care providers need to know?"
  March 2018 ,Translational Lung Cancer Research,Current Standards for Clinical Management of SCLC,"Review the latest on diagnosis, staging, and management of SCLC."
  March 2018 ,Plastic and Reconstructive Surgery,The Addition of Platelet-Rich Plasma to Facial Lipofilling,A new study examines the potential benefits of platelet-rich plasma as an additive to facial lipofilling procedures.
  March 2018 ,U.S. Pharmacist,New Drug Review 2017,"Find out what there is to know about promising new treatments for type 2 diabetes, dermatitis, plaque psoriasis, and asthma."
  March 2018 ,Critical Care,Supplemental Parenteral Nutrition in Critically Ill Adults,How does a supplemental parenteral nutrition strategy compare with using enteral nutrition alone in terms of energy delivery?
  March 2018 ,Rheumatology,Advances in PET for the Imaging of Rheumatoid Arthritis,This article explores evolving developments in positron emission tomography for rheumatoid arthritis imaging.
  March 2018 ,Circulation,Ischemic Stroke Mandates Cross-Disciplinary Collaboration,This commentary highlights the need for cardiologists and stroke physicians to work jointly to improve the identification and treatment of ischemic stroke caused by a cardiac or aortic disorder.
  March 2018 ,Journal of the National Cancer Institute,Optimal Duration of Endocrine Therapy for Breast Cancer,"According to a new study, five years of extended adjuvant letrozole for early breast cancer was not superior to 2.5 years."
  March 2018 ,Urologic Nursing,Urinary Incontinence in Frail Older Adults,"This review explores the cause of urinary incontinence in the frail elderly population, and looks at how these patients are best assessed and managed."
  March 2018 ,Anesthesiology,Multimodality Neuromonitoring in Adult Traumatic Brain Injury,This article describes various neuromonitoring techniques used to guide the management of patients with TBI. What is the latest evidence and expert consensus guidelines for neuromonitoring?
  March 2018 ,Journal of Clinical Endocrinology & Metabolism,Vitamin D Prenatal Supplementation and Fetal Growth,"Vitamin D supplementation during pregnancy, based on current recommendations, may help improve fetal growth."
  March 2018 ,Annals of Oncology,The Use of Antidepressants in Oncology,Review practical guidance for commonly used antidepressants in patients with cancer.
  March 2018 ,Stroke,Heart Rate and Cerebrovascular Disease in the Elderly,Find out about the role of heart rate in subclinical cerebrovascular disease among the elderly.
  March 2018 ,Seminars in Respiratory and Critical Care Medicine,Emerging Concepts in Evidence-Based Asthma Management,"Emerging concepts in the management of asthma may lead to new and improved strategies for the diagnosis, assessment, and treatment of the disease."
  April 2018 ,Annals of Oncology,Watson for Oncology and Breast Cancer Recommendations,What is the level of concordance between the artificial intelligence clinical decision-support system Watson for Oncology and a breast cancer tumor board?
  April 2018 ,BMC Oral Health,Dental Caries Prevention Strategies Among Immigrant Children,Which preventive strategies for caries reduction among children and adolescents with immigrant or low socioeconomic backgrounds are most effective?
  April 2018 ,Journal of Clinical Endocrinology & Metabolism,Aspects of SDHA-Related Pheochromocytoma and Paraganglioma,A better understanding of germline SDHA variants and mutations may allow for the earlier detection of paragangliomas.
  April 2018 ,The British Journal of Dermatology,Dupilumab and QoL in Moderate-to-severe Atopic Dermatitis,"Does dupilumab, a recently approved biologic, improve clinical response and quality of life in adults with moderate-to-severe atopic dermatitis?"
  April 2018 ,Southern Medical Journal,Diverticular Disease: The Ever-Changing View,This review updates current understanding of the epidemiology and risk factors for diverticular disease. What progress has been made in prophylaxis and therapy?
  April 2018 ,Journal of the American Academy of Orthopaedic Surgeons,Compliance With the AAOS Guidelines for Treatment of Knee OA,A survey of orthopaedic surgeons provides insight into treatment practices for knee OA. Are they in line with currently recommended guidelines?
  April 2018 ,Spine,Do Physical Activities Trigger Low Back Pain Flare-Ups?,A new study looks at whether low back pain flare-ups occur in response to physical activities.
  April 2018 ,American Journal of Cardiovascular Drugs,CoQ10 Supplementation and Statin-Associated Muscle Symptoms,"Deficiency of CoQ10, or ubiquinone, has been proposed as a mechanism underlying statin-associated muscle symptoms. This review examines the current evidence."
  April 2018 ,Journal of the Endocrine Society,GLP-1 and Insulin and Microvasculature and Conduit Artery,A new study examines the impacts of GLP-1 and insulin on muscle microvasculature and conduit artery in healthy adults.
  March 2018 ,Chinese Clinical Oncology,CAR T and Other T Cell Strategies for Pancreatic Cancer,Review the biology of T cell therapy and its potential role in pancreatic cancer therapy.
  March 2018 ,Journal of Clinical Endocrinology & Metabolism,Metabolic Characteristics of Adult-Onset Autoimmune Diabetes,What do we currently know about the metabolic features of patients with autoimmune diabetes shortly after diagnosis?
  March 2018 ,BMC Anesthesiology,Dexmedetomidine Prevents AKI After Adult Cardiac Surgery,Acute kidney injury following cardiac surgery is a serious complication. Might perioperative administration of dexmedetomidine reduce the risk in adult patients?
  March 2018 ,Liver International,Sofosbuvir/Velpatasvir in HCV With Cirrhosis or Fibrosis,Is the combination of sofosbuvir and velpastavir a safe and effective therapeutic option for patients with HCV and advanced fibrosis or cirrhosis?
  March 2018 ,Clinical Gastroenterology and Hepatology,Telemedicine for Delivery of Care in Chronic Liver Disease,Telemedicine may be useful for treatment of chronic hepatitis C and periprocedural management of liver disease.
  March 2018 ,Critical Care,Tracheal Intubation in Critically Ill Patients,This article presents a comprehensive review of current knowledge regarding tracheal intubation in the critically ill.
  March 2018 ,Arthritis Research & Therapy,Nonradiographic AS: Clinical and Therapeutic Relevance,How is nonradiographic axial spondyloarthritis distinguished from radiographic disease -- and how do management strategies differ?
  March 2018 ,Alimentary Pharmacology & Therapeutics,Tofacitinib and Biological Therapies for Ulcerative Colitis,Tofacitinib is currently under review as induction and/or maintenance therapy for adult patients with moderate-to-severe ulcerative colitis. How does it compare with other biologics?
  March 2018 ,Current Opinion in Ophthalmology,Review of the Xen Gel Stent and InnFocus MicroShunt,These new devices for subconjunctival glaucoma surgery show promising early clinical results in terms of safety and IOP reduction.
  March 2018 ,Nephrology Dialysis Transplantation,Low-Protein Diet in Chronic Kidney Disease,How useful are low-protein diets in chronic kidney disease patients?
  March 2018 ,Human Reproduction,Time to Redefine Endometriosis to Include Fibrotic Nature,Some think redefining endometriosis could limit false negative diagnoses and offer new treatment targets.
  April 2018 ,American Nurse Today,When the Heart Stops: Life-Giving Updates on Cardiac Arrest,"When a hospitalized patient experiences sudden cardiac arrest, timely intervention is imperative."
  April 2018 ,Brain,Cognitive Ageing and Alzheimer's Disease,"What role does the cholinergic system, via direct neurotransmission or broader neuromodulatory influence, play in the Alzheimer's disease process?"
  April 2018 ,American Journal of Clinical Pathology,Delay to Formalin Fixation Effect on Breast Cancer Molecules,"What effect does delay to formalin fixation have on breast biomarkers such as ER, PR, HER2, Ki-67, and others? Might DFF be a confounding factor in breast biomarker assays?"
  April 2018 ,Journal of Viral Hepatitis,QoL in Adolescents With HCV Treated With Sofosbuvir+Ribavirin,How does treatment with DAAs and viral eradication affect health-related quality of life in adolescent patients with HCV?
  April 2018 ,Clinical Gastroenterology and Hepatology,HRQoL and Costs Associated With Eosinophilic Esophagitis,"This study evaluated the disease burden and the economic impact of eosinophilic esophagitis, a chronic, immune-mediated disorder, for patients, their caregivers, and the healthcare system."
  April 2018 ,Translational Lung Cancer Research,Targeting DNA Repair in SCLC and the Biomarker Landscape,"Areas of investigation for SCLC include identification of predictive biomarkers, effective combinations to overcome resistance, and strategies for immunotherapy."
  April 2018 ,Clinical Endocrinology,Optimal Iodine Supplementation During ATD for Graves Disease,How might iodine supplementation vs iodine restriction impact the efficacy of antithyroid treatment and the prognosis of Graves disease?
  April 2018 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,HIV Drug Resistance in Early vs Delayed ART,HIV patients who initiated early ART realized a reduced rate of drug resistance than those who started later.
  April 2018 ,Journal of the National Cancer Institute,Chemotherapy-Associated Neuropathy in Early Breast Cancer,Neuropathic symptoms may persist in over 80% of patients receiving adjuvant chemotherapy for early breast cancer.
  April 2018 ,Stroke,Stroke Risk Factors Unique to Women,"This article explores stroke risk factors experienced exclusively by women, including exogenous estrogens, pregnancy, parity, and menopause."
  April 2018 ,Current Opinion in Rheumatology,Recent Advances in the Treatment of Rheumatoid Arthritis,What recent progress has been made regarding the available therapeutic options for rheumatoid arthritis?
  April 2018 ,The British Journal of Dermatology,Biologics and Biosimilars for Moderate-to-severe Psoriasis,"Several biosimilars are now available for biologic therapies used to treat moderate-to-severe plaque psoriasis. This study compares long-term safety, efficacy, and drug survival data on these agents."
  April 2018 ,European Heart Journal,TRL-C: The Ugly Stepsister of LDL-C,Primary prevention of cardiovascular disease in patients with hypertriglyceridemia is an unmet need.
  April 2018 ,Rheumatology,The BSR Guideline for the Management of SLE in Adults,A new guideline from the British Society for Rheumatology offers guidance for the management of systemic lupus erythematosus in adults.
  April 2018 ,American Journal of Public Health,More Research Needed on Increasing HPV Vaccine Uptake,"Why does the HPV vaccine continue to have such a low rate of acceptance, and how must we revise policies to increase uptake? The answers still aren't clear."
  April 2018 ,Journal of the American Geriatrics Society,Delirium: A Framework to Improve Acute Care for Older Persons,"The author explores the multifactorial etiology of delirium in the elderly, its precipitating factors, and prevention in this comprehensive treatise."
  April 2018 ,Critical Care,"Vasoplegia Treatments: The Past, the Present, and the Future",Learn more about the current treatments and new therapies on the horizon for vasoplegia.
  April 2018 ,Endocrine Practice,A Guide to Biosimilars and Follow-On Biologics of Insulin,Find out what there is to know about biosimilars and follow-on biologics of insulin. How do they differ from standard generics?
  April 2018 ,Nephrology Dialysis Transplantation,Cholecalciferol and Hyperparathyroidism Progression in CKD,A new study examines the effects of a higher dose of cholecalciferol on parathyroid hormone levels in patients with CKD.
  April 2018 ,OJIN: The Online Journal of Issues in Nursing,Empowering ePatients to Drive Healthcare Reform -- Part III,ePatients are driving the evolution of the healthcare delivery system by taking an active role in managing their health. What can nurses do to help empower these patients?
  May 2018 ,The British Journal of Dermatology,Use of Systemic Corticosteroids for Atopic Dermatitis,"Despite recommendations against the use of systemic corticosteroids for atopic dermatitis, their use remains widespread. Under what limited circumstances is it appropriate to use them?"
  May 2018 ,Alimentary Pharmacology & Therapeutics,Long-term Safety of Oral Anti-virals for Chronic HBV,What does the latest evidence tell us about the long-term safety profiles of nucleoside analogues for chronic hepatitis B?
  May 2018 ,Nursing Economics,ARNs: Evolving Role Perceptions in Clinical Care Teams,"How do attending registered nurses view their role, and how has their perception changed over time?"
  May 2018 ,Pain,Pain As a Risk Factor for Common Mental Disorders,This study examined the association of pain with the development of first or recurrent episodes of common mental disorders. Might pain management serve as a preventative in some cases?
  April 2018 ,Alimentary Pharmacology & Therapeutics,Perspective on the Clinical Meaningfulness of IBD Trials,A new survey provides insight into the views of physicians regarding the clinical relevance of the results of IBD trials.
  April 2018 ,American Family Physician,ACC/AHA Hypertension Guideline: What Is New? What Do We Do?,Recently released hypertension guidelines from the ACC and AHA have lowered the BP cutoff from 140/90 to 130/80 mm Hg--but the AAFP doesn't endorse this change. How should this impact your practice?
  April 2018 ,BMC Pulmonary Medicine,Inappropriate or Excessive Asthma Reliever Medication Use,Which asthma patients may be more likely to engage in the excessive use of short-acting beta agonists?
  April 2018 ,Endocrine Practice,Management of Diabetes During Air Travel,How should patients who will be traveling on long-haul flights best manage their diabetes medications?
  April 2018 ,Pain,Machine Learning in Pain Research,How are machine-learning technologies being applied to pain research? This article explores how the emerging discipline of computational pain research provides new tools to further our understanding.
  April 2018 ,Journal of Viral Hepatitis,Telbivudine to Prevent Mother-to-Child Transmission of HBV,Does telbivudine in women with positive HBeAg prevent HBV transmission to the fetus--and is it safe to use in the third trimester?
  April 2018 ,Breast Cancer Research,SSRI Use and Breast Cancer Survival: Cohort Study,Is SSRI use associated with breast cancer mortality?
  April 2018 ,Clinical Endocrinology,Long-term Safety of Growth Hormone,What does the current data tell us about the long-term safety of recombinant human growth hormone treatment?
  April 2018 ,Skin Therapy Letter,Brodalumab: A Review of Safety,"This article reviews the publicly available safety data for brodalumab, an interleukin-17R inhibitor approved for chronic plaque psoriasis. Is its safety profile similar to other IL-17 antagonists?"
  April 2018 ,Current Opinion in Ophthalmology,Deep Learning Applications in Ophthalmology,Find out how deep learning models could apply within the field of ophthalmology.
  April 2018 ,Current Opinion in Gastroenterology,DAA Treatment for Patients With Hepatocellular Carcinoma,"What factors need to be considered when using DAAs for HCV in patients with HCC? Review recent findings surrounding indications, efficacy and outcomes associated with DAA treatment in these patients."
  April 2018 ,Applied Radiology,Breast Elastography: A New Paradigm in Diagnostic Imaging,"Learn about breast ultrasound elastography, an imaging modality which provides increased specificity and sensitivity in differentiating benign from malignant lesions."
  April 2018 ,Headache,Headache in Nontraumatic Subarachnoid Hemorrhage,"Headaches associated with SAH may present differently than non-SAH headaches with characteristics such as meningismus and a ""stabbing"" quality."
  April 2018 ,Age and Ageing,Frailty Index as a Predictor of Mortality,Research confirms that frailty measured by the Frailty index is a significant predictor of mortality.
  April 2018 ,Liver International,OBV/PTV/r+DSV+RBV in Patients With HCV Cirrhosis,Does real-life data confirm the results of clinical trials regarding the efficacy and safety profile of this DAA regimen in patients with HCV infection and cirrhosis?
  April 2018 ,The British Journal of Dermatology,Topical Crisaborole in the Treatment of Atopic Dermatitis,"While phase III studies of crisaborole have shown it to be a safe treatment that improves symptoms of atopic dermatitis, does it really offer substantive therapeutic benefit over standard therapies?"
  May 2018 ,BMC Oral Health,Patient Views and the Design of Oral Care for Older People,"The paper explores approaches to facilitate partnerships between researchers, healthcare professionals, and patients in the design of healthcare services for older people, with a focus on oral health."
  May 2018 ,Age and Ageing,Pain Assessment in the Older Population,This commentary summarizes the revised evidence-based Guidelines on the Assessment of Pain in Older Adults which have been developed by the British Pain Society and British Geriatrics Society.
  May 2018 ,Liver International,Long-term Follow-up: Daclatasvir-based Regimens for HCV,This study evaluated the long-term outcomes and safety of daclatasvir-based regimens for chronic HCV infection administered during clinical trials.
  May 2018 ,Seminars in Neurology,New Directions in the Treatment of Glioblastoma,"Glioblastoma has a dismal prognosis, despite multimodality treatment, but new insights into GBM genomics and pathogenesis offer hope for the development of next-generation therapies."
  May 2018 ,Anesthesiology,Abuse-Deterrent Opioid Formulations,How do abuse-deterrent opioid formulations work--and are they effective? This review details the mechanisms and pharmacology of 10 abuse-deterrent formulations currently approved in the US.
  May 2018 ,Journal of Oncology Practice,Geriatric Assessment for Older Patients With Cancer,"Not only can a geriatric assessment evaluate medical, psychosocial, and functional problems in older patients with cancer, it can also predict toxicity and guide interventions."
  May 2018 ,The Gerontologist,Older Adult Music Listeners: Increased Engagement With Life?,"What role might music play in older adults' cognitive, physical, social, and spiritual functioning? How might listening to music relate to overall engagement with life and benefits to health?"
  May 2018 ,Critical Care Medicine,Procalcitonin-Guidance for Antimicrobial Management,How effective are procalcitonin-guided strategies in the antibiotics management of ICU patients?
  May 2018 ,Nephrology Dialysis Transplantation,Mortality in Patients on Hemodiafiltration vs Hemodialysis,Might hemodiafiltration patients realize better outcomes than those receiving hemodialysis?
  May 2018 ,BMC Pulmonary Medicine,Impact of Omalizumab Treatment in Severe Allergic Asthma,A new study provides a clinical and cost analysis regarding the use of omalizumab in the treatment of severe asthma.
  May 2018 ,Clinical Endocrinology,Delayed Initial Radioiodine Therapy in Thyroid Cancer,The initiating time of radioiodine therapy in differentiated thyroid cancer may impact the individual response to therapy.
  May 2018 ,AIDS,Adverse Reactions to Integrase Strand Transfer Inhibitors,"Integrase strand transfer inhibitors are widely used in HIV infected patients, but what do we currently know about the adverse reactions associated with these antiretroviral drugs?"
  May 2018 ,BMC Oral Health,Glass Hybrids for Restoring Hypomineralized Molars,This study evaluated the survival rate of restorations performed using a new glass hybrid restorative system in first permanent molars affected by molar incisor hypomineralization.
  May 2018 ,Journal of the National Cancer Institute,Communicating Measures of Treatment Effect on Survival,"Novel measures, such as mean survival times and net benefit, are suggested for the analysis of phase III oncology trials."
  May 2018 ,BMC Pulmonary Medicine,High-Dose Corticosteroid Treatment and Mortality in ARDS,Past studies have shown that high-dose corticosteroid therapy did not improve the outcomes of patients with ARDS -- but is it time to revisit the issue?
  May 2018 ,American Journal of Transplantation,Treatment of Chronic Antibody Mediated Rejection,Is IVIG combined with rituximab a safe and effective treatment option for chronic antibody mediated rejection?
  May 2018 ,Urologic Nursing,A Video Pelvic Floor Muscle Exercise Model Pre-Prostatectomy,Find out how an instructional video could help educate patients regarding pre-operative pelvic floor muscle exercises to improve post-prostatectomy incontinence.
  May 2018 ,Morbidity & Mortality Weekly Report,Artemether-Lumefantrine for Malaria in Pregnant Women,These new CDC recommendations suggest artemether-lumefantrine as an option for treatment of uncomplicated malaria in pregnant women during the second and third trimesters of pregnancy.
  May 2018 ,Annals of Oncology,Management of Toxicities Associated With Bosutinib,Review strategies for managing toxicities associated with bosutinib in patients with Ph+ chronic phase CML.
  May 2018 ,Anesthesiology,New Opioid Analgesic Approvals and Utilization in the US,How has the introduction of the many new opioid analgesics approved by the USFDA since 1997 changed patterns of opioid prescribing?
  June 2018 ,Circulation,Ezetimibe: Likely to Be Beneficial For All,Is ezetimibe therapy equally beneficial to patients with or without diabetes mellitus? This commentary focuses on the clinical implications of the IMPROVE-IT trial.
  June 2018 ,Annals of Oncology,Prognostic Value of Primary Tumor Side in RAS Wild-Type mCRC,"In RAS wild-type mCRC, patients with right-sided tumors have a worse prognosis than those with left-sided tumors, and efficacy of treatment is sided as well."
  May 2018 ,Alimentary Pharmacology & Therapeutics,Probiotics in the Management of Lower GI Symptoms,"This review presents the latest evidence for the use of probiotics in the management of specific lower gastrointestinal symptoms, updating the prior 2013 international guidelines."
  May 2018 ,European Heart Journal,Lipids and Lipid Lowering With Statins and PCSK9 Inhibitors,"This commentary summarizes multiple recent studies on the use of statins and PCSK9 inhibitors as well as new insights into the relationship of HDL, LDL, the immune system, and atherosclerosis."
  May 2018 ,Wounds,A Biofilm-Disrupting Agent for Managing Chronic Wounds,How does a biofilm-disrupting wound gel compare with standard of care treatment in terms of wound volume reduction?
  May 2018 ,Clinical Gastroenterology and Hepatology,Definitions of Endpoints for RCTs of Ulcerative Colitis,"The authors propose the collaborative development of a core outcome set to standardize efficacy and safety reporting in ulcerative colitis RCTs, providing a conceptual framework for such development."
  May 2018 ,Journal of Viral Hepatitis,Estimating HCV Prognosis Using Transient Elastography,Is non-invasive transient elastography as accurate as histologic assessment of fibrosis progression rates in estimating prognosis in treatment-naive chronic hepatitis C patients?
  May 2018 ,BMC Anesthesiology,Advances and Challenges in Anesthesia Technology,The authors of this editorial highlight the many advances in anesthesia technology which have contributed to improving the quality of perioperative care. What more still needs to be addressed?
  May 2018 ,BMC Oral Health,Consequences of Early Extraction of First Permanent Molar,Does early extraction of compromised first permanent molars negatively impact the skeletal and dental development of 5- to 15-year-olds?
  May 2018 ,Journal of Clinical Endocrinology & Metabolism,Treatment Options for Hirsutism,What are the available pharmacologic treatment options for hirsutism -- and how effective are they?
  May 2018 ,Annals of Oncology,St Gallen International Conference on Early Breast Cancer,The St Gallen International Expert Consensus Conference has issued new treatment recommendations for women with early-stage breast cancer and guidance for clinicians who manage this population.
  May 2018 ,Journal of Clinical Oncology,Immune-Modifed Response Evaluation Criteria In Solid Tumors,Does this modified RECIST criteria better reflect efficacy of cancer immunotherapy for solid tumors?
  May 2018 ,Spine,Thromboprophylaxis in Spinal Surgery,How does the incidence of thromboembolic complications after spinal surgery compare between prophylaxis type?
  May 2018 ,Translational Lung Cancer Research,Combining Proton Beam Therapy and Immunotherapy,Are outcomes improved in patients with NSCLC receiving both proton beam therapy and immunotherapy?
  May 2018 ,Stroke,Role of Blood Lipids in the Development of Ischemic Stroke,"What roles do LDL cholesterol, HDL cholesterol, and triglycerides play in the development of ischemic stroke and its 3 main subtypes?"
  May 2018 ,Arthritis Research & Therapy,Longitudinal Stability of Fibromyalgia Symptom Clusters,A new study examines the stability of individual fibromyalgia symptom clusters and provides insight into how symptom patterns might change.
  May 2018 ,Critical Care,The Emerging Role of the Microbiota in the ICU,How might knowledge regarding the gut and lung microbiome contribute to the field of intensive care medicine? Could there be therapeutic implications?
  May 2018 ,Alimentary Pharmacology & Therapeutics,Vancomycin for Primary Sclerosing Cholangitis,This review summarizes the current evidence on the use of vancomycin in the treatment of primary sclerosing cholangitis and explores future research areas of interest.
  May 2018 ,Journal of the American Academy of Orthopaedic Surgeons,Surgical Procedures for Chronic Lateral Ankle Instability,Learn more about the surgical options for managing chronic lateral ankle instability.
  May 2018 ,Chinese Clinical Oncology,Trastuzumab Emtansine in HER2 Metastatic Breast Cancer,Recent survival results lead some to question the optimal sequence for trastuzumab emtansine in metastatic breast cancer.
  June 2018 ,American Journal of Clinical Pathology,Contemporary Evaluation of Breast Lymph Nodes in Pathology,This review highlights evidence from recent practice-changing clinical trials on new approaches to sentinel lymph node biopsy and axillary lymph node dissection in breast cancer patients.
  June 2018 ,American Journal of Transplantation,Outcomes in Renal Allografts With Deceased Donors,What does this study tell us about the effects of HLA matching on the outcomes of deceased-donor kidney allografts?
  June 2018 ,Journal of the Endocrine Society,ADT and Prolongation of QTc Interval in Prostate Cancer,Could changes in QTc duration during androgen deprivation therapy for prostate cancer help explain the increased risk for cardiovascular events in these patients?
  June 2018 ,Journal of Clinical Endocrinology & Metabolism,Pheochromocytoma/Paraganglioma and Cancer Metabolism,A better understanding of the metabolic pathophysiology in pheochromocytomas/paragangliomas may lead to more targeted treatment for these tumors.
  June 2018 ,Pediatric Pharmacotherapy,News for Pediatric Healthcare Providers From the FDA,Which drugs have been newly developed or indicated for pediatric patients? Find out what there is to know.
  June 2018 ,Seminars in Respiratory and Critical Care Medicine,Immunosuppression: Have We Learnt Anything?,This review looks at the findings from recent clinical trials regarding the use of immunosuppression after lung transplantation.
  June 2018 ,Annals of Oncology,Time Is Up for PD-L1 Testing Standardization in Lung Cancer,Rapid efforts are needed to determine analytical concordance between PD-L1 assays.
  June 2018 ,BMC Oral Health,Cone Beam Computed Tomography in Implant Dentistry,"When should cone beam computed tomography be used in implant dentistry, and what advantages does it provide? These and other questions about the use of CBCT are covered in this comprehensive article."
  June 2018 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Twenty-Five Years of Lamivudine,"After 25 years, lamivudine continues to be recommended as part of ART regimens for HIV."
  June 2018 ,Nephrology Dialysis Transplantation,Hemoglobin Concentration and Stroke Risk in Hemodialysis,Might low hemoglobin concentrations contribute to the risk for hemorrhagic or ischemic stroke among hemodialysis patients?
  June 2018 ,Laboratory Medicine,CTCs as a Predictive Biomarker in Suspected Ovarian Cancer,Might circulating tumor cells be useful as a diagnostic biomarker in women with complex pelvic masses?
  June 2018 ,Journal of the American Academy of Orthopaedic Surgeons,Comparisons for Nonsurgical Treatment of Knee OA,How do these non-surgical treatment options for managing knee OA compare in terms of efficacy?
  June 2018 ,European Heart Journal,Heart Failure in Diabetic Patients,Patients with T2DM are at increased risk of developing heart failure. This report discusses several new directions in advanced imaging and therapeutics which can improve treatment for these patients.
  June 2018 ,Neurosurgical Focus,Outpatient Spine Surgery: Value and Barriers to Implementation,A controversial cost reduction strategy involves transitioning certain spinal procedures to an outpatient setting. Which surgeries might lend themselves to this approach...and what are the obstacles?
  June 2018 ,Journal of Clinical Oncology,First-Line Treatment of Hormone-Sensitive Metastatic PCa,"In addition to standard ADT, which patients with hormone-sensitive metastatic prostate cancer should receive abiraterone, docetaxel, both, or neither?"
  June 2018 ,Alimentary Pharmacology & Therapeutics,Vedolizumab and Simultaneous Exposure to an Anti-TNF,Might the combination of vedolizumab with anti-TNF confer better clinical outcomes than each drug alone? This study examined the safety and efficacy of this combination regimen in patients with IBD.
  June 2018 ,American Journal of Pharmaceutical Education,A Simulation to Increase Empathy in Pharmacy Students,"This study assessed the efficacy of a program designed to encourage the pharmacy student to empathize with those managing multi-drug, multi-dose medication regimens."
  June 2018 ,Stroke,Cell Therapy for Chronic Stroke,"How might stem cell therapy enhance recovery in recurrent stroke? This paper explores mechanisms of action, stem cell types, routes of administration, and current evidence supporting this approach."
  June 2018 ,Critical Care,Urinary Biomarkers Predict AKI After Cardiovascular Surgery,"Urinary biomarkers, in combination with clinical risk scores, may help predict the progression of acute kidney injury after cardiovascular surgery."
  June 2018 ,BMC Anesthesiology,Administration of Sufentanil and Opioid Induced Cough,Might changing the administration of sufentanil from a peripheral route to a central vein reduce the occurrence and severity of opioid-induced cough?
  July 2018 ,Brain,Grey Matter Atrophy for Staging Neurodegeneration in MS,"A new study proposes a novel look at the process of neurodegeneration in multiple sclerosis, positing that it can be staged by grey matter atrophy progression over time."
  July 2018 ,Alcohol and Alcoholism,Craving as a DSM-5 Symptom of Alcohol Use Disorder,DSM-5 has added craving as a new symptom in alcohol use disorder. How will this impact AUD prevalence estimates?
  July 2018 ,Current Opinion in Rheumatology,Advances in Spondyloarthritis: Glimpse in the Future,Recent advances have led to a better understanding of the pathogenesis of spondyloarthritis as well as improved imaging and treatment modalities. Find out where this exciting field is headed.
  July 2018 ,Current Opinion in Psychiatry,Comprehensive Interventions for Reducing Cannabis Use,"What interventions are most effective for preventing and reducing cannabis use? This article provides an overview of current psychosocial, pharmacological and risk reduction recommendations."
  July 2018 ,Nephrology Dialysis Transplantation,Renal Replacement Therapy Intensity for Acute Kidney Injury,How does higher intensity dose renal replacement therapy compare with standard intensity in terms of survival and renal recovery in severe acute kidney injury?
  July 2018 ,Alimentary Pharmacology & Therapeutics,"Acetaminophen, NSAIDs and Risk of IBD Exacerbation",Does the use of NSAIDs or COX-2 inhibitors exacerbate Crohn's disease or ulcerative colitis?
  July 2018 ,Journal of Clinical Oncology,Curing More Prostate Cancer: Thinking Through the Options,Clinical trials in prostate cancer often take years or decades to yield results. Can time to results be lessened?
  July 2018 ,Arthritis Research & Therapy,A Low-Intensity Lifestyle Intervention for Knee Pain,Could a simple lifestyle intervention help reduce knee pain among rural women?
  July 2018 ,The British Journal of Dermatology,Dupilumab With Topical Corticosteroids for Atopic Dermatitis,Atopic dermatitis patients refractory to topical therapy have few treatment options. This study evaluated the efficacy of the newly approved biologic dupilumab in this difficult-to-treat population.
  July 2018 ,BMC Pulmonary Medicine,Telerehabilitation for Chronic Respiratory Disease,Is a home-based telerehabilitation program as effective as traditional pulmonary rehabilitation for patients with chronic respiratory disease?
  July 2018 ,Critical Care,Mechanical CPR: Who? When? How?,When is it appropriate to administer mechanical CPR -- and which patients would most benefit? This article provides some guidance.
  July 2018 ,Endocrine Practice,Sitagliptin-Metformin Therapy in Prior Gestational Diabetics,Find out about the benefits treatment with sitagliptin combined with metformin may provide prediabetic women with a history of gestational diabetes.
  July 2018 ,BMC Anesthesiology,Patient Satisfaction With Epidural Analgesia for Labour Pain,What clinical and demographic factors might influence patient satisfaction in women receiving epidural analgesia for labor pain relief?
  June 2018 ,BMC Pulmonary Medicine,Anti-Fibrotic Effects of Pirfenidone and Rapamycin in IPF,Could the combination of pirfenidone and rapamycin provide a new anti-fibrotic therapeutic approach for the treatment of idiopathic pulmonary fibrosis?
  June 2018 ,Nephrology Dialysis Transplantation,A Tool for Incremental Hemodialysis Prescription,"A new, easy to use spreadsheet may be a helpful tool for the prescription of incremental hemodialysis."
  June 2018 ,Chinese Clinical Oncology,Emerging Role of Immunotherapy for Childhood Cancers,Immunotherapeutic strategies are showing promise for pediatric cancers such as leukemia and neuroblastoma. What is the latest research?
  June 2018 ,Journal of Cardiovascular Electrophysiology,In Memoriam: ARTHUR J. MOSS MD,"This tribute to the legacy of Dr. Arthur J. Moss, MD, highlights his pioneering work on sudden cardiac death and long-QT syndrome."
  June 2018 ,Age and Ageing,New Horizons in Systemic Anti-cancer Therapy in Older People,"What are the specific challenges faced by older persons with regards to systemic anti-cancer therapy, and how can we improve cancer therapeutics for this population?"
  June 2018 ,Menopause,Intravaginal Testosterone for Vulvovaginal Atrophy,Is there sufficient evidence to recommend the use of intravaginal testosterone as treatment for vulvovaginal atrophy? Is it safe for women with breast cancer taking an aromatase inhibitor?
  June 2018 ,BMC Pulmonary Medicine,Improved Heart Hemodynamics After Draining Pleural Effusion,"Patients with massive pleural effusion realized improved cardiac hemodynamics following drainage, a new study reports."
  July 2018 ,Neurosurgical Focus,Predicting Recovery From SMA Syndrome Post Brain Tumor Surgery,This study investigated the hypothesis that interhemispheric connectivity of the primary motor cortex in one hemisphere with the contralateral SMA may be important in the recovery from SMA syndrome.
  July 2018 ,American Nurse Today,Using Aromatherapy in the Clinical Setting,The use of essential oils in patient care settings may help decrease stress and improve mood for both nurses and their patients.
  July 2018 ,Headache,"Concussion: A History of Science and Medicine, 1870-2005","This essay highlights key research and discoveries from the long history of concussion science. How have perceptions, attitudes and understanding evolved since the mid-19th century?"
  July 2018 ,Journal of the Endocrine Society,Hypertriglyceridemia in Diabetes Mellitus,A new study examines the pathophysiology of hypertriglyceridemia in children with diabetes mellitus. Could it play a role in the later development of cardiovascular disease?
  July 2018 ,BMC Pulmonary Medicine,Bronchiectasis: An Emerging Global Epidemic,"Bronchiectasis is increasingly becoming a significant global issue, and more evidenced-based research is needed to evolve our understanding of the disease."
  July 2018 ,Annals of Oncology,CD19 Antibody MOR208 in Relapsed or Refractory B-Cell NHL,"MOR208, an Fc-engineered, humanized, CD19 antibody, shows promise in rituximab-refractory B-cell NHL and follicular lymphoma."
  July 2018 ,Chinese Clinical Oncology,The Emerging Role of Oncolytic Virus Therapy Against Cancer,Review the latest on oncolytic virotherapy and viruses currently in clinical testing.
  July 2018 ,American Journal of Cardiovascular Drugs,Combination Therapy for Pulmonary Arterial Hypertension,"This article reviews practical recommendations for the use of combination therapy for the treatment of pulmonary arterial hypertension, including monitoring and management of side effects."
  July 2018 ,Rheumatology,Recent Pharmacological Advances in the Management of Gout,What's new in the pharmacological treatment of gout?
  July 2018 ,Skin Therapy Letter,Chronic Urticaria: Following Practice Guidelines,"This article summarizes proposed updated guidelines for the management of chronic urticaria, incorporating new information regarding biologics and 2nd generation antihistamines."
  July 2018 ,Journal of Clinical Endocrinology & Metabolism,Increased Plasma Proneurotensin Levels Identify NAFLD,A new study investigates the relationship between plasma proneurotensin levels and nonalcoholic fatty liver disease or nonalcoholic steatohepatitis.
  July 2018 ,Journal of the National Cancer Institute,Implications of CTCs in Early Breast Cancer,Can CTCs be used to predict prognosis and response to neoadjuvant chemotherapy in nonmetastatic breast cancer?
  July 2018 ,Age and Ageing,Effectiveness of Probiotics on Infections in Older People,Might probiotics reduce the occurrence of infections in older adults?
  July 2018 ,Stroke,Ticagrelor and Aspirin Use the Week Before Randomization,This new analysis of the SOCRATES trial explored the efficacy and safety of ticagrelor versus aspirin in patients who received any aspirin the week before randomization.
  July 2018 ,Annals of Oncology,Antibiotics Affect Activity of Immune Checkpoint Inhibitors,Does the altering of gut microbiota by antibiotics reduce the efficacy of immune checkpoint inhibitors?
  July 2018 ,Plastic and Reconstructive Surgery,IDEAL IMPLANT Structured Breast Implants,What advantages might this new structured breast implant offer over silicone gel implants?
  July 2018 ,Pediatric Pharmacotherapy,Use of Acetaminophen for Patent Ductus Arteriosus Closure,This article provides an update regarding the use of acetaminophen to close a patent ductus arteriosus.
  July 2018 ,Morbidity & Mortality Weekly Report,Geographic Variation in Pediatric Cancer Incidence -- US,Which US region has the highest rate of pediatric cancers? This report tracked pediatric cancer incidence by type and state.
  July 2018 ,Current Opinion in Allergy and Clinical Immunology,Is the Evidence of Local Allergic Rhinitis Growing?,"Recent advances have led to a better understanding of the pathophysiology, diagnosis, and treatment of local allergic rhinitis. Find out what there is to know."
  July 2018 ,Clinical Endocrinology,Use of Salivary Cortisol and Cortisone in the Synacthen Test,A new study examines the correlation between serum cortisol and salivary cortisol and cortisone following the synacthen test.
  August 2018 ,Southern Medical Journal,Association Between the Frank Sign and Cardiovascular Events,This review summarized current evidence for a correlation between the Franks sign--a diagonal earlobe crease--and cardiovascular disease. What might its pathophysiological basis be?
  August 2018 ,Age and Ageing,Impact of Antihypertensive Treatment in the Oldest-Old,Controversy remains regarding the appropriateness of lowering systolic blood pressure in persons over 80. Does hypertensive therapy put them at higher risk of mortality and cognitive decline?
  August 2018 ,Alimentary Pharmacology & Therapeutics,Tong-Xie-Yao-Fang vs Placebo for Diarrhea-Predominant IBS,Might the Chinese herbal formula Tong-Xie-Yao-Fang be effective in controlling symptoms of IBS-D?
  August 2018 ,HIV Medicine,First-Line ART With EFV or RPV Plus TDF/FTC,How do these first-line combination antiretroviral therapy regimens compare in terms of tolerance and durability?
  August 2018 ,Alcohol and Alcoholism,Efficacy of Alcohol Interventions for Incarcerated People,How effective are current alcohol interventions in the prison setting?
  August 2018 ,Arthritis Research & Therapy,Sarilumab Monotherapy vs Adalimumab Monotherapy in RA,What benefits might sarilumab monotherapy offer over adalimumab monotherapy in the treatment of rheumatoid arthritis?
  August 2018 ,BMC Pulmonary Medicine,Vitamin D Supplementation Effects on Tuberculosis Outcomes,Should vitamin D supplementation be considered as part of an anti-tuberculosis regimen? What improvements might it offer these patients?
  August 2018 ,Annals of Oncology,Neoadjuvant Score as Surrogate for DFS in Rectal Cancer,A score incorporating categories for disease-free survival can help clinicians make faster decisions about treatment for rectal cancer.
  August 2018 ,Journal of Viral Hepatitis,Timing of HCV Therapy in Liver Transplant-Eligible Patients,The authors developed a decision tree model to compare the cost-effectiveness of three strategies for timing of DAA treatment for HCV in liver transplant candidates.
  August 2018 ,Headache,Posttraumatic Headache: Mechanisms and Therapeutic Targets,"Frequent or continuous headache is common after head trauma. This review outlines key clinical characteristics of posttraumatic headache, its pathophysiology, and its optimal management."
  August 2018 ,American Journal of Clinical Pathology,Metastatic Involvement of the Prostatic Anterior Fat Pad,Is pathologic evaluation of the prostatic anterior fat pad useful for prostate cancer staging in cases with low preoperative risk of recurrence?
  August 2018 ,Rheumatology,Difficult-to-Treat RA: An Area of Unmet Clinical Need,Which factors may contribute to difficult-to-treat rheumatoid arthritis and what are the best management approaches?
  August 2018 ,Schizophrenia Bulletin,Gaps Between Clinical Trials and Patient Treatment,"In this commentary, the authors outline shortcomings in the knowledge-base related to antipsychotic medications, highlighting disconnects between clinical trial results and real-life clinical use."
  August 2018 ,Journal of Cardiovascular Electrophysiology,Have We Reached the Point of Primary Prevention for AF?,"Should we offer primary prevention therapy for patients at risk of atrial fibrillation, even before the arrhythmia has occurred? What are the risks, and which patients would benefit?"
  August 2018 ,Journal of the National Cancer Institute,Antioxidant for Taxane-Induced Neuropathy,Be careful with antioxidants. Research finds that acetyl-L-carnitine worsened taxane-associated peripheral neuropathy.
  August 2018 ,Stroke,Prediction of Tissue Outcome in Acute Ischemic Stroke,"Using a deep neural network, the authors present a predictive model capable of identifying and combining MRI imaging features to accurately predict final lesion volume in acute ischemic stroke."
  August 2018 ,Annals of Oncology,Trials Evaluating New Drugs Added to R-CHOP for DLBCL,Molecularly targeted and monoclonal antibodies used with R-CHOP in DLBCL have fallen short in phase III trials. Are phase II trials to blame?
  July 2018 ,Pediatric Nursing,Accuracy of Non-Core Thermometer Devices vs Core Body Temp,How accurate are these non-core thermometer devices for measuring body temperature? How do they compare to core body temperature?
  July 2018 ,Journal of Clinical Endocrinology & Metabolism,Effects of Diazoxide on Glucose and Lipid Metabolism,Could treatment with diazoxide help reduce insulin levels without increasing glucose levels?
  July 2018 ,BMC Anesthesiology,DEX and Dose Requirement in Spinal Anesthesia for C-Section,"Can intrathecal dexmedetomidine potentiate hyperbaric bupivacaine in spinal anesthesia for patients undergoing caesarean, without additional side effects?"
  September 2018 ,Alimentary Pharmacology & Therapeutics,First- and Second-line Biologic Therapies for Crohn's Disease,"Several biologic agents are now available for first- and second- line treatment of Crohn's disease, but head-to-head trials are lacking. This meta-analysis aimed to compare efficacy of these agents."
  September 2018 ,Brain,Serum Neurofilament Light Chain Levels as MS Biomarker,Can serum neurofilament light chain levels serve as a biomarker for disease progression and outcome in multiple sclerosis?
  September 2018 ,Liver International,OBV/PTV/r +/- DSV in HCV GT4-infected Patients With Severe CKD,This study investigated the real-world efficacy of ombitasvir/paritaprevir/ritonavir +/- DSV regimen in HCV genotypes 4 and 1 patients with advanced chronic kidney disease.
  September 2018 ,Neurosurgical Focus,Approaches to Closed-loop DBS for Movement Disorders,This paper summarizes investigational approaches to closed-loop systems of deep brain stimulation for treatment of movement disorders. Which approaches hold most promise?
  September 2018 ,Stroke,Imaging in Suspected Acute Ischemic Stroke Due to LVO,A survey of expert vascular neurologists indicates a wide disparity of approaches to imaging in acute ischemic stroke patients who are potential thrombectomy candidates. Is there an optimal protocol?
  September 2018 ,Journal of the American Board of Family Medicine,Hyperlipidemia: Management With PCSK9 Inhibitors,"This article reviews the mechanism of action of PCSK9 inhibitors, as well as their efficacy, safety, costs, and limitations. For which patients are they recommended?"
  September 2018 ,Journal of Cardiovascular Electrophysiology,Catheter Ablation of AF in HF With Reduced Ejection Fraction,Catheter ablation for AF in HF patients with reduced ejection fraction is increasingly being used as an alternative to pharmacological therapy. Review its efficacy and safety in this article.
  September 2018 ,Alimentary Pharmacology & Therapeutics,Definitions for Anti-fibrotic Stricture Therapies in CD,"By standardizing definitions for diagnosis, endpoints, and treatment targets, this consensus statement aims to improve drug development for anti-fibrotic therapies for stricturing Crohn's disease."
  September 2018 ,HIV Medicine,Accuracy of Screening Tools for HIV Neurocognitive Disorders,A new study examines the diagnostic performance of four screening tools for the assessment of neurocognitive disorders among HIV-positive patients.
  September 2018 ,Journal of Viral Hepatitis,HCV Viral Subtypes and SVR Rates in Trials of DAA Regimens,This study aimed to provide a comprehensive description of subtype diversity and treatment outcomes in clinical trials of DAA regimens for the less common HCV subtypes.
  September 2018 ,Anesthesia & Analgesia,ACE Inhibitors and ARBs Before Surgery: An Ongoing Dilemma,Confusion still reigns regarding the discontinuation of these common antihypertensive medications prior to elective surgery. What's the prudent path to take?
  September 2018 ,The British Journal of Dermatology,Subcutaneous Methotrexate in Moderate-to-Severe Psoriasis,A new study investigates the efficacy of an intensified two-step dosing schedule of subcutaneous methotrexate in patients with moderate-to-severe chronic plaque psoriasis.
  August 2018 ,BMC Pulmonary Medicine,Peak Inspiratory Flow Rates via Dry Powder Inhalers in COPD,How do peak inspiratory flow rate values vary with the utilization of different dry powder inhalers for COPD?
  August 2018 ,BMC Anesthesiology,Opioid Choice and Postop Recovery After Laparoscopic Surgery,Does the choice of opioids during surgery affect a patient's postoperative quality of recovery?
  August 2018 ,Human Reproduction,Reproduction After the Loss of a Child,This study examined women's reproductive trajectory following the death of a child. Is the death of a child associated with higher subsequent fertility?
  August 2018 ,Current Opinion in Ophthalmology,Botulinum Toxin Injection and Tear Production,Botulinum toxin type A injections provide a non-invasive treatment option for a number of ophthalmic conditions. What do we know about its impact on tear production?
  August 2018 ,Current Opinion in Nephrology and Hypertension,Iron Therapy for Managing Anemia in Chronic Kidney Disease,Iron replacement therapy is an important component in the management of CKD anemia. Which route of administration is best?
  August 2018 ,Liver International,HCV Treatment Initiation in Persons With CKD in the DAAs Era,New DAA regimens have now been approved for treatment of HCV infected persons with advanced chronic kidney disease. Are treatment rates improving in this population?
  August 2018 ,Alimentary Pharmacology & Therapeutics,Recurrence of HCC Following Direct-acting Antiviral Therapy,Might direct-acting antivirals increase risk and aggressiveness of hepatocellular carcinoma recurrence? This review aimed to characterize HCC recurrence patterns after DAA therapy.
  August 2018 ,BMC Pulmonary Medicine,BF Spiromax vs BF Turbuhaler Inhaler Techniques in Asthma,With which of these two different inhalers were patients with asthma most able to achieve device mastery?
  October 2018 ,Stroke,Trial of Navigated rTMS for Motor Recovery in Stroke,Does low-frequency rTMS delivered to the noninjured hemisphere improve motor gains after hemiplegic stroke?
  October 2018 ,Alimentary Pharmacology & Therapeutics,Systemic Treatment of Hepatocellular Carcinoma,This review discusses the evolution of targeted therapy with tyrosine kinase inhibitors and recent developments in immunotherapy for systemic treatment of hepatocellular carcinoma.
  October 2018 ,Pain,"Does the Word ""Placebo"" Evoke a Placebo Response?","In this commentary, the author posits that the increase in the placebo response in clinical trials may be due to a change in the general public's conception of what ""placebo"" means."
  October 2018 ,Anesthesia & Analgesia,Patient-Controlled vs Clinician-Controlled Propofol Sedation,How does patient-controlled sedation with propofol compare with clinician-controlled sedation in terms of risks and benefits?
  September 2018 ,European Heart Journal,Past President of ESC Takes a Look at Where It Now Stands,Jeroen Bax discusses achievements and challenges during his time as president of ESC.
  September 2018 ,Circulation,COMPASS and Thrombotic Risk Reduction in Stable CVD,In which patients should low-dose rivaroxaban plus aspirin be strongly considered for secondary prevention?
  September 2018 ,Alcohol and Alcoholism,The Relationship Between Men's Drinking and Depression,"Because problem drinking may worsen depression over time, screen men with either or both conditions closely."
  September 2018 ,Stroke,Using Imaging to Select for Late Window Endovascular Therapy,"After acute stroke, MRI and computed tomography perfusion may be useful for selecting appropriate candidates for late window thrombectomy."
  September 2018 ,Skin Therapy Letter,Alitretinoin for Management of Chronic Hand Dermatitis,"This article summarizes real-world evidence supporting the safety and effectiveness of alitretinoin, an oral retinoid, in the management of chronic hand dermatitis."
  September 2018 ,Journal of Clinical Endocrinology & Metabolism,CV Risk in Hypertriglyceridemic Patients With LDL-C Control,Elevated triglyceride levels may contribute to a greater risk for cardiovascular disease despite statin-controlled LDL cholesterol levels.
  September 2018 ,Alimentary Pharmacology & Therapeutics,Risk of NAFLD in Celiac Patients on a Gluten-free Diet,Does a gluten-free diet impact the risk of developing nonalcoholic fatty liver disease in patients with celiac disease?
  September 2018 ,Menopause,Estrogen-alone Therapy and Invasive Breast Cancer Incidence,"Studies have demonstrated increased breast cancer risk associated with postmenopausal hormone therapy, but does risk vary depending on dose, formulation, and route of delivery of estrogen-alone HT?"
  September 2018 ,The British Journal of Dermatology,A Multistep Algorithm to Detect In Situ Melanomas,The authors present a multistep diagnostic algorithm for in situ melanoma detection using reflectance confocal microscopy combined with dermoscopy.
  September 2018 ,Brain,What Is to Blame for Cognitive Decline in Ageing?,What are the key drivers of cognitive decline in the elderly? A new study suggests that amyloidosis and neurodegeneration have both independent and synergistic effects.
  September 2018 ,Critical Care,Definitions and Pathophysiology of Vasoplegic Shock,Gain insight into the clinical definitions of vasoplegic shock and the processes involved in the development of this condition.
  September 2018 ,Journal of Clinical Endocrinology & Metabolism,Macimorelin as a Diagnostic Test for Adult GH Deficiency,The oral macimorelin test may be a safe and reliable alternative to the insulin tolerance test for the diagnosis of adult GH deficiency.
  September 2018 ,Journal of the Endocrine Society,Osteoanabolic Agents for Osteoporosis,Find out what there is to know about the currently available osteoanabolic therapies for osteoporosis.
  September 2018 ,Current Opinion in Allergy and Clinical Immunology,Ocular Allergy as a Risk Factor for Dry Eye,"Ocular allergy and dry eye are different conditions, yet there are complex interactions between them. Find out what there is to know."
  September 2018 ,Alimentary Pharmacology & Therapeutics,Association Between PPIs and Hepatocellular Carcinoma,Might long-term use of proton pump inhibitors increase the risk of hepatocellular carcinoma?
  September 2018 ,Arthritis Research & Therapy,Infliximab Biosimilar vs Infliximab Reference Product for RA,"How does this infliximab biosimilar and the reference product compare in terms of efficacy, safety, pharmacokinetics, and immunogenicity?"
  October 2018 ,BMC Anesthesiology,Topical Ropivacaine and Endotracheal Tube Extubation,Might topical ropivacaine before intubation reduce the incidence of postoperative throat pain and cough during extubation?
  October 2018 ,Urologic Nursing,Recurrent Urinary Tract Infection Care,What role might complementary and alternative medicine have in the management of recurrent urinary tract infections?
  October 2018 ,The British Journal of Dermatology,Oral Propranolol in the Treatment of Infantile Hemangiomas,These guidelines provide consensus recommendations on the treatment of infantile hemangiomas with oral propranolol.
  October 2018 ,Circulation,NOACs for Mechanical Heart Valves: Is the Door Still Open?,"Currently, NOACs are contraindicated in patients with mechanical heart valves based on the results of a single study comparing dabigatran and warfarin. Does this need to be re-evaluated?"
  October 2018 ,HIV Medicine,Switching From Tenofovir in HIV Patients With Renal Toxicity,Might a treatment switch help reverse the nephrotoxic effects associated with tenofovir use?
  October 2018 ,Stroke,IVT Remains the Basis and Mainstay of Revascularizing Therapy,"Do we need IVT before EVT? In this commentary, the authors maintain that IVT before EVT remains the standard of care for acute stroke, regardless of arguments to the contrary."
  October 2018 ,Journal of Oncology Practice,Medical Marijuana Use in a Community Cancer Center,About 20% of patients receiving chemotherapy are using marijuana according to a new study. Is use associated with cancer stage?
  October 2018 ,Neurosurgical Focus,The Challenges of Global Neurosurgery in East Africa,This article spotlights the Neurosurgery Education and Development Foundation and the work they are doing to provide neurosurgical care and improve neurosurgical education in East Africa.
  October 2018 ,Current Opinion in Psychiatry,Enhanced CBT for Patients With Eating Disorders,"Is CBT-E an effective treatment for adults with an eating disorder? This review examined the latest evidence for its efficacy in bulimia nervosa, binge eating disorder and transdiagnostic samples."
  October 2018 ,Journal of the National Cancer Institute,Outcomes With Celecoxib and Aspirin in AI-Treated Patients,Does short-term celecoxib or low-dose aspirin use decrease risk of breast cancer recurrence?
  October 2018 ,American Journal of Pharmaceutical Education,Challenges for Pharmacy in the Era of Precision Medicine,How can pharmacists prepare for their role in advancing precision and personalized therapies?
  October 2018 ,Journal of Viral Hepatitis,Eight Weeks of Antiviral Therapy for Recent HCV Infection,Is an 8-week therapy of paritaprevir/ritonavir/ombitasvir and dasabuvir + ribavirin as effective as the standard 12-week regimen in individuals with recent HCV infection?
  October 2018 ,The British Journal of Dermatology,Nivolumab vs Ipilimumab in Treatment of Advanced Melanoma,A new study compares nivolumab in combination with ipilimumab or nivolumab vs. ipilimumab monotherapy for extending overall or progression-free survival in adults with advanced melanoma.
  October 2018 ,Rheumatology,Current and Emerging Therapies in Large-Vessel Vasculitis,This review discusses the conventional treatments for large-vessel vasculitis as well as the potential of new biologic therapies.
  October 2018 ,Journal of Clinical Oncology,Updated GADOLIN Study Shows Survival Benefit in Indolent NHL,An updated analysis of the GADOLIN study confirms the PFS benefit of obinutuzumab and bendamustine in rituximab-refractory indolent non-Hodgkin lymphoma.
  October 2018 ,Critical Care,Corticosteroid Use and Intensive Care Unit-Acquired Weakness,Is there an association between corticosteroid use and ICU-acquired weakness?
  October 2018 ,AIDS,Antiretroviral Therapy and Brain Aging Changes in HIV,Is antiretroviral therapy for HIV associated with aging-related cerebral degenerative changes? Which drugs may cause these adverse effects?
  October 2018 ,Liver International,RBV Dosing in HCV Receiving OBV/PTV/r and DSV With RBV,This analysis describes the clinical management of ribavirin dosing among HCV patients receiving a direct-acting antiviral regimen. When should dose modifications be considered?
  October 2018 ,Journal of the American Geriatrics Society,Frailty and Resilience as Outcome Measures in Geriatric Care,The author examines the complex concepts of frailty and resilience and explores differing approaches to their use as outcome measures in the context of geriatric care.
  October 2018 ,BMC Pulmonary Medicine,The All Age Asthma Cohort (ALLIANCE),The ALLIANCE cohort study aims to unravel the complex mechanisms behind the development of wheeze and asthma phenotypes across all ages.
  November 2018 ,Annals of Oncology,Efficacy of Trabectedin in Elderly Patients With Sarcoma,Elderly patients with good performance status benefit from trabectedin for soft tissue sarcoma similarly to younger patients.
  November 2018 ,Alimentary Pharmacology & Therapeutics,Novel Antivirals for Hepatitis C,"This review spotlights two novel pangenotypic regimens for HCV infection, SOF/VEL/VOX for patients previously treated with NS5A inhibitors, and G/P for patients with advanced kidney disease."
  November 2018 ,BMC Pulmonary Medicine,Bronchial Thermoplasty Reduces Gas Trapping in Severe Asthma,A new study uses body plethysmography to evaluate the changes in gas trapping following bronchial thermoplasty for severe asthma.
  November 2018 ,Journal of the American Geriatrics Society,Daily Sleep Duration and Risk of Dementia and Mortality,This study aimed to elucidate the association between daily sleep duration and risk of dementia and death in a community-dwelling elderly population. Does use of hypnotics influence the risk?
  November 2018 ,Current Opinion in Rheumatology,Gastrointestinal Involvement in Systemic Sclerosis,How are gastrointestinal complications related to systemic sclerosis best diagnosed and managed?
  November 2018 ,HIV Medicine,Exposure to ART Drugs and Incidence of Hypertension in HIV,Is there an association between specific antiretroviral drugs and an increased risk of hypertension?
  November 2018 ,Anesthesia & Analgesia,Update on Perioperative Acute Kidney Injury,"This review discusses the epidemiology and pathophysiology of surgery-associated acute kidney injury, highlighting the importance of intraoperative oliguria. What are potential preventive strategies?"
  November 2018 ,Journal of the National Cancer Institute,Do NSAIDs Prevent Breast Cancer Recurrence?,"While it has been suggested that NSAIDs may reduce cancer recurrence, a new study finds this not to be the case."
  November 2018 ,Anesthesiology,Caffeine Accelerates Emergence From Isoflurane Anesthesia,There are currently no drugs available to reverse the coma-like state induced by general anesthetics. Might IV caffeine accelerate anesthetic emergence without ill effects?
  October 2018 ,Translational Lung Cancer Research,Lung Ground-Glass Nodules in Never-Smokers and Smokers,How long should ground glass nodules of the lung be monitored and what are predictors of their growth?
  October 2018 ,BMC Pulmonary Medicine,Cardiopulmonary US for Diagnosing ARDS in Elderly Patients,Could cardiopulmonary ultrasound help improve the accuracy of ARDS diagnosis in elderly patients?
  October 2018 ,Wounds,The Effects of Aloe Vera on Wound Healing,What do we currently know about the mechanisms of aloe vera treatment in wound healing?
  October 2018 ,The British Journal of Dermatology,Tildrakizumab for Moderate-to-Severe Plaque Psoriasis,Is tildrakizumab therapy a safe and effective treatment option for moderate-to-severe plaque psoriasis?
  October 2018 ,HIV Medicine,Comparing Efficacies of E/C/F/TAF and NRTI-Sparing Regimens,How do these two HIV treatment regimens compare in terms of 48-week efficacy?
  October 2018 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Choosing Between Daily and Event-Driven PrEP,"When it comes to pre-exposure prophylaxis, do patients prefer daily or event-driven regimens? Which factors may influence their choice?"
  October 2018 ,Current Opinion in Ophthalmology,Update on Giant Cell Arteritis,Get up-to-date on the latest advances in diagnostic imaging modalities and treatment options for giant cell arteritis.
  October 2018 ,Chinese Clinical Oncology,Advances of Systemic Treatment for Adult Soft-Tissue Sarcoma,Trabectedin and eribulin are showing promise for the treatment of soft tissue sarcoma.
  October 2018 ,AIDS,p24 Revisited: Antigen Detection for Early HIV Diagnosis,This review explores the promising role of the p24 antigen assay in the early detection of HIV.
  October 2018 ,Liver International,Efficacy of Elbasvir and Grazoprevir in HCV Genotype 4,A once-daily combination treatment regimen of elbasvir and grazoprevir may be an effective therapeutic option for chronic HCV genotype 4 infection.
  October 2018 ,Headache,CBT for Insomnia to Reduce Chronic Migraine,Do behavioral interventions for insomnia decrease migraine frequency?
  November 2018 ,Southern Medical Journal,PHP and Shared Medical Appointments for Patients With T2DM,This study aimed to provide practitioners with insights into offering a shared medical appointment intervention to T2DM patients through a collaborative personalized health planning approach.
  November 2018 ,Medicine and Science in Sports and Exercise,Daily Composition of Movement Behaviors and Blood Pressure,A new study investigates the association between the daily composition of movement behaviors and blood pressure.
  November 2018 ,Nephrology Dialysis Transplantation,Effect of Dapagliflozin in T2D Patients With Stages 3b-4 CKD,Is dapagliflozin an effective therapeutic option for patients with type 2 diabetes and chronic kidney disease? How does it impact clinical outcomes in these patients?
  November 2018 ,Skin Therapy Letter,Chronic Pruritus: Neurophysiology and Neuromodulatory Therapy,Learn about recent progress in our understanding of the molecular and neurophysiological mechanisms governing pruritus. How might immunomodulatory drugs be used to treat this debilitating condition?
  November 2018 ,Laboratory Medicine,Diagnostic Value of Circulating Cell-Free DNA in Breast Cancer,"Using qPCR, this study examined the utility of circulating cell-free DNA in auxiliary diagnosis, grading of malignant neoplasms, and prognostic prediction of breast cancer."
  November 2018 ,Current Opinion in Allergy and Clinical Immunology,Allergen Immunotherapy as Add-on to Biologic Agents,A new review examines recent evidence regarding the addition of biological treatments to allergen-specific immunotherapy. What have we learned?
  November 2018 ,Endocrine Practice,IDegLira vs Insulin Glargine U100 Plus Insulin Aspart,Is IDegLira a more cost-effective treatment choice for type 2 diabetes than insulin glargine U100 plus insulin aspart?
  November 2018 ,Alimentary Pharmacology & Therapeutics,Risk Factors for Postoperative Recurrence in Crohn's Disease,This study aimed to identify predictors of postoperative endoscopic recurrence in Crohn's disease patients who have undergone ileocolonic resection.
  November 2018 ,European Heart Journal,"LVADs: A Better Quality of Extended Life, Away From Hospital",A new study provides a better understanding of the potential real-life benefits of left ventricular assist devices in patients with advanced heart failure.
  November 2018 ,Emerging Infectious Diseases,TB Treatment Monitoring by Video Directly Observed Therapy,Is this video-based approach a feasible means of assessing tuberculosis treatment adherence?
  November 2018 ,American Journal of Clinical Pathology,Diagnosis of Lymphoid Lesions in Limited Samples,This review provides practical guidelines for diagnosis of lymphoid lesions in smaller samples obtained from minimally invasive procedures.
  November 2018 ,Headache,Migraine in America Symptoms and Treatment (MAST) Study,"This article summarizes both the design and the findings of the MAST study, an epidemiologic survey of people with migraine in the United States."
  November 2018 ,Journal of Cardiovascular Electrophysiology,Long-term Risk of Stroke and Bleeding Post-AF Ablation,Should oral anticoagulants be discontinued after catheter ablation for atrial fibrillation--or is it prudent to continue anticoagulation post-ablation?
  November 2018 ,Europace,Inappropriate Doses of DOACs in Real-world Clinical Practice,The findings of this study indicate that nearly one-third of patients received an inappropriate dose of DOAC in a real-world clinical setting. What factors might lead to this concerning result?
  November 2018 ,Journal of the American Board of Family Medicine,Interruption of DOACs in Preprocedural and Acute Settings,How long should direct thrombin inhibitors be held prior to invasive procedures?
  November 2018 ,Anesthesiology,Nomenclature of Cognitive Change Associated With Surgery,"A working group proposes a formal classification of nomenclature for cognitive change affecting patients after anesthesia and surgery, consistent with terminology used in the wider clinical community."
  November 2018 ,Wounds,Durability of an Advanced Skin Protectant,How durable is this new and improved skin protectant compared with other similar products?
  November 2018 ,European Heart Journal,Estimating Treatment Effects From Observational Data in HF,"Can we make reliable therapeutic decisions based on the findings of non-randomized, observational studies describing the effects of treatment in heart failure patients?"
  November 2018 ,BMC Pulmonary Medicine,Early Pulmonary Rehabilitation After COPD Exacerbations,A supervised early pulmonary rehabilitation program may help reduce the risk of mortality among hospitalized patients with COPD-related exacerbations.
  November 2018 ,HIV Medicine,Decision Making in HIV-1 Post-Exposure Prophylaxis,Which factors may influence prescription decisions for HIV post-exposure prophylaxis?
  December 2018 ,BMC Anesthesiology,SAPB for Minimal Invasive Heart Surgery,Can serratus anterior plane block reduce morphine consumption and improve management of post-operative pain when compared with continuous wound infiltration following minimal invasive heart surgery?
  December 2018 ,Nephrology Dialysis Transplantation,JAK Inhibition by Baricitinib in Diabetic Kidney Disease,How does treatment with baricitinib impact albuminuria and diabetic kidney disease progression in patients with type 2 diabetes?
  December 2018 ,AIDS,Cost-Effectiveness of PrEP for HIV Prevention for Conception,A new study examines the economic value of preexposure prophylaxis to help prevent the perinatal transmission of HIV. How does it compare with other conception strategies?
  December 2018 ,Journal of the American Academy of Orthopaedic Surgeons,Predicting Adverse Outcomes After Total Hip Arthroplasty,Which of these comorbidity indices most accurately predicts postoperative adverse outcomes among patients undergoing total hip arthroplasty?
  December 2018 ,Spine,Clinical Characteristics of Recurrent Lumbar Disk Herniation,Learn more about the clinical features and risk factors associated with the recurrence of lumbar disc herniation after surgical treatment.
  December 2018 ,Journal of Oncology Practice,Challenges and Opportunities With EHRs for Oncologists,Front-line oncologists describe the 6 main problems with EHRs.
  December 2018 ,The British Journal of Dermatology,Ixekizumab for Moderate-to-Severe Genital Psoriasis,Genital psoriasis is a challenging manifestation of psoriasis with significant negative impacts on sexual health and quality of life. Is ixekizumab effective for this difficult to treat condition?
  December 2018 ,Journal of the Endocrine Society,Navigating Systemic Therapy in Advanced Thyroid Carcinoma,Find out more about the available treatment options for advanced cases of thyroid cancer.
  November 2018 ,BMC Oral Health,Can a Brief CBT Intervention Improve Oral Health Behaviour?,"A form of cognitive behavioral therapy, Acceptance and Commitment Therapy, demonstrated potential to improve oral health behavior in young adults with poor oral health in this study."
  November 2018 ,Circulation,Conducting the ISCHEMIA Trial: Setting the Record Straight,Contributors to the ISCHEMIA trial provide insights into why they made certain trial design modifications after the trial started enrolling patients.
  November 2018 ,Annals of Oncology,Outcomes and PFS at 24 Months for Patients With DLBCL,The potential for positive survival outcomes is excellent in patients with DLBCL who have not progressed 24 months after receiving rituximab-containing immunochemotherapy.
  November 2018 ,Family Practice Management,What Makes a Doctor Truly Great,"In this commentary, Dr Kenny Lin singles out the one skill that separates the merely competent doctors from the truly great ones."
  November 2018 ,Chinese Clinical Oncology,Next Frontiers in Systemic Therapy for Soft Tissue Sarcoma,Molecularly targeted therapy and immunotherapy are changing the treatment landscape of soft tissue sarcoma.
  November 2018 ,Clinical Endocrinology,Statin Medications and the Risk of Gynecomastia,Is the use of statins associated with an increased risk of gynecomastia?
  November 2018 ,The British Journal of Dermatology,Tofacitinib for Moderate-to-Severe Chronic Plaque Psoriasis,"This study describes the long-term safety profile of tofacitinib, an oral Janus kinase inhibitor, in patients with moderate-to-severe plaque psoriasis."
  November 2018 ,American Journal of Clinical Pathology,CINtec PLUS Triage in Cervical Cytology and HPV Screening,"These findings of this study highlight the potential of CINtec PLUS, a promising new biomarker test, to improve management pathways in HPV-positive women."
  November 2018 ,Annals of Surgery,Half of Postop Deaths After Hepatectomy May Be Preventable,What are the main causes of postoperative mortality after hepatectomy -- and how can these events be prevented?
  November 2018 ,Rheumatology,How to Use Bisphosphonates Safely and Optimally,Learn more about the potential adverse events associated with bisphosphonate therapy and the optimal duration of treatment.
  November 2018 ,Journal of Clinical Endocrinology & Metabolism,"Cognition, HR QoL, Psychosocial Functioning After GH/GnRHa",How does combined GnRHa and GH treatment affect these outcomes in early adulthood?
  December 2018 ,Translational Andrology and Urology,Clinical Implications of PET/CT in Prostate Cancer,"How does PET/CT compare with other imaging modalities for the diagnosis, staging, and management of prostate cancer?"
  December 2018 ,BMC Pulmonary Medicine,Adherence to Inhaled Therapy and Its Impact on COPD,Poor adherence to prescribed inhalation therapy may increase the risk for exacerbations and hospitalization among COPD patients.
  December 2018 ,Exercise and Sport Sciences Reviews,Exercise and Bariatric Surgery,What benefits might the implementation of a structured exercise program offer bariatric surgery patients?
  December 2018 ,Human Reproduction,Non-invasive Pre-implantation Genetic Testing of Embryos,Genetic testing of cell-free embryonic DNA in blastocoel fluid may prove to be a viable non-invasive alternative to conventional biopsy-derived pre-implantation genetic testing.
  December 2018 ,Headache,AHS Position Statement: Integrating New Migraine Treatments,This position statement from the American Headache Society provides updated recommendations to healthcare professionals on the use of currently available preventive and acute treatments for migraine.
  December 2018 ,Pediatric Pharmacotherapy,Posaconazole Use in Infants and Children,This article provides an update regarding the use of posaconazole for antifungal prophylaxis and treatment in pediatric patients.
  December 2018 ,Headache,Medication Overuse Headache in Chronic Migraine,Why are some chronic migraine patients more prone than others to relapse after structured withdrawal for medication overuse? This study explored psychosocial features that might contribute to relapse.
  December 2018 ,Anesthesia & Analgesia,Neostigmine and Atropine for Postdural Puncture Headache,Might the addition of neostigmine and atropine improve the efficacy of conventional management for postdural puncture headache?
  December 2018 ,Europace,CRT in Heart Failure: Is the Defibrillator Needed?,Questions still remain as to the additive benefit of the defibrillator as an adjunct to cardiac resynchronization therapy.
  December 2018 ,Stroke,Higher Incidence of Ischemic Stroke in Patients Taking NOACs,Does the reduced risk of nontraumatic bleeding in patients taking NOACs as opposed to warfarin come at the cost of a higher risk of ischemic stroke?
  December 2018 ,Current Opinion in Urology,Focal Therapy of Prostate Cancer,What does the latest evidence tell us about the use of focal therapy for the treatment of prostate cancer?
  December 2018 ,American Journal of Transplantation,Implications of a More Timely Living Kidney Donor Evaluation,What are the impacts of an earlier living kidney donor evaluation?
  December 2018 ,Annals of Oncology,Quality of Life Needs in Older Patients With Cancer,A position paper from the International Society of Geriatric Oncology recommends that clinicians place a greater focus on the quality of life of older adults living with cancer.
  December 2018 ,Annals of Family Medicine,Adults' Preferences for Discussing Long-term Life Expectancy,How reluctant are older adults when it comes to discussing long-term life expectancy?
  December 2018 ,Nephrology Dialysis Transplantation,Vitamin D Deficiency and Mortality in Maintenance Dialysis,Findings from a new study highlight the need for clinical trials investigating the effects of vitamin D supplementation among patients receiving hemodialysis.
  December 2018 ,Journal of Medical Case Reports,Alectinib-induced Reversible Grade IV Nephrotoxicity,"This case underscores the potential of the tyrosine kinase inhibitor alectinib to cause severe grade 4 renal toxicity, which was reversible in this patient with metastatic lung cancer."
  December 2018 ,Journal of Clinical Oncology,Tumor Mutation Burden as a Biomarker in Resected NSCLC,Use of tumor mutation burden may help identify patients who can achieve a more pronounced survival benefit from adjuvant chemotherapy for NSCLC.
  December 2018 ,The British Journal of Dermatology,Biological Therapy and Cancer Risk in Patients With Psoriasis,Does long-term exposure to systemic immunomodulatory therapies increase the risk of cancer in patients with psoriasis?
  December 2018 ,Rheumatology,Drug Safety and Immunogenicity of TNF Inhibitors,What have we learned about the safety and immunogenicity of tumor necrosis factor inhibitors?
  December 2018 ,Breast Cancer Research,Ribociclib for Advanced HR+ Breast Cancer,"The combination of ribociclib, a CDK 4/6 inhibitor, and letrozole may be used successfully in a broad population of patients with advanced HR+/HER2- breast cancer."
  December 2018 ,Journal of the National Cancer Institute,Improving Work Outcomes Among Cancer Survivors,Training programs are needed to help employers improve communication with cancer survivors and facilitate workplace accommodations.
  January 2019 ,Journal of Viral Hepatitis,Liver Function Post-HCV Therapy in Patients With/Without HIV,This study compared the changes in several markers of liver function between HCV-monoinfected and HIV/HCV-coinfected patients with cirrhosis who achieved SVR after DAA therapy.
  January 2019 ,Liver International,8 Weeks of PTV/r/OBV/DSVin HCV With Mild-moderate Fibrosis,"This study assessed the efficacy and safety of the 8-week administration of PTV/r/OBV/DSV in a real-world cohort of treatment-naive, HCV genotype 1b-infected patients with mild to moderate fibrosis"
  January 2019 ,Menopause,The Mysteries of Menopause and Urogynecologic Health,This article explores the relationship of menopausal estrogen levels to the epidemiology and pathogenesis of common pelvic floor disorders and genitourinary syndromes of menopause.
  January 2019 ,Pediatric Nursing,"Axillary, Tympanic, and Temporal Thermometry Comparison",What are the benefits of a temporal scanner in pediatric practice -- and how does it compare to other thermometry methods?
  January 2019 ,American Journal of Transplantation,Novel Biomarker for Acute Rejection After Kidney Transplant,"Subclinical acute rejection after kidney transplantation is currently only detectable with surveillance biopsies, but a novel biomarker may offer a new alternative."
  January 2019 ,BMC Pulmonary Medicine,Degree of Control of Patients With COPD,How successful are COPD patients at controlling symptoms and managing their disease? The SINCON study provides some insight.
  January 2019 ,Pediatric Pharmacotherapy,Stiripentol Use in Children With Refractory Seizures,This article summarizes current knowledge regarding the use of stiripentol as an add-on therapy for the treatment of refractory seizures in children.
  January 2019 ,Current Opinion in Infectious Diseases,Managing Acinetobacter baumannii Infections,"A. baumannii is commonly involved in nosocomial infections, but few therapeutic options are available. Find out what there is to know."
  January 2019 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Advancing HIV Prevention Research for At-Risk Adolescents,The inclusion of at-risk youth in HIV prevention research is crucial to advancing our understanding of the efficacy and safety of PrEP use in this population.
  January 2019 ,Brain,The Search for Pain Biomarkers in the Human Brain,"Controversy continues on the usefulness of functional neuroimaging to measure pain. How should these neuroimaging ""biomarkers"" be interpreted--and is a new approach needed?"
  January 2019 ,JCO Precision Oncology,Next-Generation Sequencing Tests to Guide Cancer Treatment,"A survey finds that oncologists use NGS tests to guide decisions on management of refractory disease, eligibility for clinical trials, and off-label use of drugs."
  January 2019 ,The British Journal of Dermatology,An App to Improve Adherence to Topical Therapy in Psoriasis,Can a smartphone app which provides daily reminders to psoriasis patients improve short-term adherence to a standard topical treatment regimen?
  January 2019 ,Wounds,Time to Abandon Antimicrobial Approaches in Wound Healing,"Antimicrobials are commonly used in wound care, but it may be time to rethink that approach."
  December 2018 ,Translational Lung Cancer Research,Chemotherapy Strategies in Malignant Pleural Mesothelioma,Is immunotherapy beneficial in patients with progressive malignant pleural mesothelioma after initial platinum-based chemotherapy?
  December 2018 ,Pediatric Nursing,Pediatric Obesity in Primary Practice,What can primary care providers do to help prevent childhood obesity and its complications?
  December 2018 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Patient Adherence to DRV/r Combined With RAL or TDF/FTC,Did patient adherence to these regimens influence the efficacy results of the NEAT001/ANRS143 trial?
  December 2018 ,Age and Ageing,Technology in Geriatrics,What role can--and should--technology play in geriatric care? How can new technologies be integrated into existing health and social service systems? Explore the issues in this paper.
  December 2018 ,Nephrology Dialysis Transplantation,Novel Oral Anticoagulants in Patients With CKD and AF,"Novel oral anticoagulants are often used in patients with chronic kidney disease and atrial fibrillation, but what do we know about the benefits and risks of these agents in this population?"
  December 2018 ,OJIN: The Online Journal of Issues in Nursing,Translation Research in Practice: An Introduction,What is translation science? Find out more about this field of investigation and learn how it can help improve the implementation of evidence-based interventions.
  December 2018 ,The British Journal of Dermatology,Alopecia Areata: A Review of Disease Pathogenesis,"This article offers new insights into the pathophysiological mechanisms involved in the etiology of alopecia areata, an incurable autoimmune disorder."
  February 2019 ,European Heart Journal,Catheter-based Renal Denervation: The Next Chapter Begins,What have recent studies shown us about the feasibility and efficacy of catheter-based renal denervation as an antihypertensive strategy--and where do we go from here?
  February 2019 ,AIDS,Optimizing HIV Prevention and Care for Transgender Adults,"What strategies may help improve transgender-specific HIV prevention, treatment, and management?"
  February 2019 ,European Heart Journal,The Year in Cardiology 2018: Acute Coronary Syndrome,This article traces advances in our understanding and treatment of acute coronary syndromes from the 1950s to the present day. What's the next frontier?
  February 2019 ,BMC Anesthesiology,Anesthetic Choice During Spinal Anesthesia for Hip Fracture,Do levobupivacaine and bupivacaine differ in their impact on cerebral O2 saturation during spinal anesthesia? How might that impact cognitive status and neurological complications in the elderly?
  February 2019 ,Journal of Pediatric Psychology,Family Functioning and Pediatric Medical Adherence,"How does the overall family environment as well as specific family functioning components such as conflict, communication, and problem-solving influence pediatric medication adherence?"
  February 2019 ,Journal of Viral Hepatitis,Current Therapies and Viral and Immune Responses in HBV,This review summarizes current and future directions for therapeutic options for chronic HBV infection. Is a functional cure for HBV within sight?
  February 2019 ,Nephrology Dialysis Transplantation,Effects of Vadadustat on Hemoglobin in Hemodialysis Patients,Vadadustat is a potential new treatment for anemia in chronic kidney disease -- but what do we know about its impacts in patients receiving hemodialysis?
  February 2019 ,American Journal of Clinical Pathology,Immune Response Markers in Matched RCC Tissue Specimens,"Do renal clear cell carcinoma primary tumors and metastatic deposits demonstrate discordance in the expression of immune checkpoint proteins PD-L1, PD-1, and PD-L2?"
  February 2019 ,The British Journal of Dermatology,"Tackling Melanoma by Adjuvant Therapy: Why, Whom and How?","Adjuvant targeted therapy is revolutionizing melanoma treatment, but also poses new challenges: Which patients should receive which drug, and to what end?"
  February 2019 ,Journal of Clinical Oncology,ctDNA-Defined Minimal Residual Disease in Solid Tumors,Novel study designs using circulating tumor DNA may advance development of drugs for cancer.
  February 2019 ,Annals of Oncology,Novel Therapies in Urothelial Carcinoma: Biomarker Approach,Which immunotherapies are showing promise for metastatic urothelial carcinomas?
  February 2019 ,Breast Cancer Research,Statins to Reduce Breast Cancer Recurrence and Mortality,What role do statins have in management of breast cancer?
  February 2019 ,Alimentary Pharmacology & Therapeutics,Implementation of a Low FODMAP Diet for Patients With IBS,"This review addresses many outstanding questions surrounding a low FODMAP diet for relief of IBS symptoms. Which patients will benefit? What's its long-term efficacy, acceptability, and impact on QoL?"
  February 2019 ,Arthritis Research & Therapy,How Much Allopurinol Does It Take to Get to Target Urate?,A new study considers the optimal allopurinol dosing required to achieve target serum urate in patients with gout.
  February 2019 ,Rheumatology,The Experience of Raynaud's Phenomenon in Systemic Sclerosis,A new review explores the patient impact and disease burden of Raynaud's phenomenon in systemic sclerosis.
  February 2019 ,Journal of the National Cancer Institute,Radiotherapy in Early-Stage Hormone-Sensitive Breast Cancer,Does omission of radiotherapy affect recurrence and mortality in early stage hormone-sensitive breast cancer?
  February 2019 ,Annals of Oncology,Targeted and Immune Therapeutics for Basal Cell Cancer,Review the use of hedgehog pathway inhibitors and other novel treatment options for metastatic basal cell carcinoma.
  January 2019 ,Journal of the American Board of Family Medicine,Future Directions for Practice-Based Research Networks,What areas should practice-based research networks be concentrating on moving forward? This report details the recommendations of current family medicine/primary care PBRN directors.
  January 2019 ,Translational Lung Cancer Research,Combined Modality Treatment in Mesothelioma,"Is combined modality treatment using surgery, radiotherapy and/or chemotherapy improving outcomes in malignant mesothelioma?"
  January 2019 ,BMC Anesthesiology,Tramadol for Catheter-related Bladder Discomfort,Might the antimuscarinic effect of tramadol reduce the symptoms of post-operative catheter-related bladder discomfort?
  March 2019 ,American Journal of Clinical Pathology,Widespread Incorrect Implementation of the Hoffmann Method,"The Hoffmann method for reference interval estimation is commonly implemented incorrectly. What are the implications, and what are the alternatives?"
  March 2019 ,The British Journal of Dermatology,Glucose Metabolism in Patients With Psoriasis,"What mechanisms might account for the association of psoriasis with type 2 diabetes? This study aimed to elucidate the pathophysiological link between psoriasis, glucose metabolism, and T2DM."
  March 2019 ,Journal of Oncology Practice,Ethics for Communicating to Patients With Cancer About CAM,What responsibilities do clinicians have when discussing CAM with patients who want to forgo conventional treatment?
  March 2019 ,Liver International,Predictors of NASH and Fibrosis in Non-obese NAFLD,This study aimed to identify risk factors for nonalcoholic steatohepatitis and fibrosis in NAFLD. How do clinical and histological characteristics differ between obese and non-obese patients?
  February 2019 ,Translational Lung Cancer Research,Tumor Mutation Burden in NSCLC: Tissue Versus Liquid Biopsy,"Tumor mutation burden may be a promising tool to guide immunotherapy, yet many questions need to be answered before adoption into clinical practice."
  February 2019 ,Chinese Clinical Oncology,Neoadjuvant Chemotherapy in Advanced Ovarian Cancer,Which patients with epithelial ovarian cancer should be considered for neoadjuvant chemotherapy followed by interval debulking surgery?
  February 2019 ,Current Opinion in Ophthalmology,New Treatment Modalities and Adherence in Glaucoma,Might offering new treatment options help improve adherence among glaucoma patients?
  February 2019 ,BMC Pulmonary Medicine,Characterizing IPF Patients Using Medicare Claims Data,What can claims data tell us about the characteristics and disease outcomes of elderly IPF patients?
  February 2019 ,American Journal of Epidemiology,"Reproductive Factors, Hormone Use, and Risk of B-Cell NHL",Might sex hormones play a role in the etiology of lymphoma? This study investigated the roles of reproductive factors and exogenous hormone use in risk of B-cell non-Hodgkin lymphoma.
  February 2019 ,Plastic and Reconstructive Surgery,Closed-Incision NPT in Aesthetic Surgery,What benefits might the application of closed-incision negative-pressure therapy bring to the field of aesthetic surgery?
  February 2019 ,Annals of Oncology,Axitinib as an Adjuvant Treatment of Renal Cell Carcinoma,Does the VEGF inhibitor axitinib reduce risk of recurrence in patients with locoregional RCC post nephrectomy?
  February 2019 ,Clinical Endocrinology,Sex-Specific Effects of DHEA on BMD and Body Composition,In what ways might dehydroepiandrosterone therapy impact BMD and body composition -- and how do these effects differ by gender?
  February 2019 ,Journal of the National Cancer Institute,Association Between ASCT and Survival Among Patients With MM,"Due to the survival advantage, autologous stem cell transplant should be considered for patients newly diagnosed with MM."
  February 2019 ,Morbidity & Mortality Weekly Report,Postlicensure Safety Surveillance of Shingrix,Are early safety monitoring findings for recombinant zoster vaccine (Shingrix) consistent with prelicensure clinical trial data?
  February 2019 ,U.S. Pharmacist,Alzheimer's Disease: Current and Potential New Treatments,"This paper reviews the pharmacological options which are currently available for treatment of Alzheimer disease, as well as potential new agents and approaches under investigation."
  February 2019 ,Alimentary Pharmacology & Therapeutics,Relief of Heartburn in Patients With Erosive Esophagitis,"Does a new potassium-competitive acid blocker, vonoprazan, provide more rapid relief of heartburn than standard treatment with a proton-pump inhibitor?"
  February 2019 ,BMC Oral Health,Oral Microbiomes of Children With and Without Childhood Caries,How does the microbiota of saliva and dentinal lesions differ between children who are carie-free and those with severe early childhood caries?
  February 2019 ,Journal of the American Academy of Orthopaedic Surgeons,Biologic Adjuvants for Osteochondral Lesions of the Talus,Learn more about the available biologic adjuvants to augment treatment of osteochondral lesions of the talus.
  February 2019 ,Journal of Viral Hepatitis,Improving Hepatitis C DAA Access and Uptake,How does treatment with DAAs alter the social and individual experience of living with hepatitis C? This commentary highlights the need for an individual focus for outcome measures.
  February 2019 ,Circulation,A Nail in the Coffin for IABP in AMI With Cardiogenic Shock,A 6-year follow-up of the IABP-SHOCK II study confirms lack of benefit on mortality associated with IABP placement in the setting of MI-associated cardiogenic shock.
  March 2019 ,Clinical Endocrinology,HCV Infection is Associated With Insulin Resistance,A new study examines the tissue-specific contribution to insulin sensitivity in hepatitis C. Does insulin sensitivity improve with viral eradication?
  March 2019 ,Current Opinion in Infectious Diseases,New Antibiotics for Community-Acquired Pneumonia,"The treatment of community-acquired pneumonia has become increasingly challenging due to antibiotic resistance, but the availability of new agents may offer more options."
  March 2019 ,Journal of the American Geriatrics Society,Inclusion of Older Adults in NIH-Funded Clinical Trials,Are older adults being underrepresented in clinical studies due to upper age limits for recruitment and exclusion criteria that include illnesses and medications common in the older population?
  March 2019 ,BMC Pulmonary Medicine,Development of a Clinical Nomogram for Predicting OSA,A newly developed and easy-to-use nomogram offers a new tool for the timely evaluation of patients with suspected OSA.
  March 2019 ,Pain,Improving Pain and Sleep With Behavioral Sleep Interventions,Can cognitive behavioral therapy for insomnia improve pain and sleep outcomes in aging adults?
  March 2019 ,Journal of Clinical Endocrinology & Metabolism,Vitamin D Deficiency and Ovarian Stimulation in PCOS,"In this study, the authors examine the impact of vitamin D deficiency on ovarian stimulation outcomes among women with PCOS or unexplained infertility."
  March 2019 ,Skin Therapy Letter,The Treatment of Primary Focal Hyperhidrosis,"Review the many treatment options available for primary focal hyperhidrosis, including emerging procedures such as microwave thermolysis, focused ultrasound therapy, and surgical interventions."
  March 2019 ,Plastic Reconstructive Surgery-Global Open (PRS Global Open),Implications of Aging in Plastic Surgery,In what ways might age affect plastic surgery outcomes?
  March 2019 ,Clinical Endocrinology,Testosterone for Postmenopausal Female Sexual Dysfunction,Is testosterone therapy a safe and effective treatment option for postmenopausal women experiencing sexual dysfunction?
  March 2019 ,Plastic and Reconstructive Surgery,"Making Sense of Stem Cells, Fat Grafting in Plastic Surgery",Find out what plastic surgeons need to know regarding the FDA regulations on fat grafting and stem-cell therapies and the responsible use of these entities.
  March 2019 ,Stroke,Stroke in Children: Opportunities for Improving Care,Studies reveal new information on risk factors for pediatric stroke and its complications.
  March 2019 ,Spine,Outcome of a New Total Cervical Disc Replacement Design,"A new study examines the clinical and radiological results of the ProDisc Vivo prosthesis, a new total cervical disc replacement."
  March 2019 ,JCO Precision Oncology,Genomic Assessment of ctDNA in Colorectal Cancers,Research finds that circulating tumor DNA profiles in patients with colorectal cancer are heterogeneous and most have potentially actionable alterations.
  March 2019 ,American Journal of Clinical Dermatology,Antibody-Based Therapies for Cutaneous T-Cell Lymphoma,"Monoclonal antibody therapies, such as alemtuzumab, brentuximab vedotin, and mogamulizumab, are showing promise for previously relapsed and refractory CTCL."
  March 2019 ,Journal of the American Geriatrics Society,Tools for Deprescribing in Frail Older Persons,The authors evaluated 15 tools designed to assist clinicians in identifying and reducing or stopping potentially inappropriate medications in frail older persons or those near the end of life.
  March 2019 ,BMC Oral Health,Oral Health Status and Its Determinants Among Opiate Users,Persons with drug addiction have a high prevalence of oral health problems. This study investigated the oral health status and its determinants among in-treatment opiate dependents.
  March 2019 ,BMC Anesthesiology,Risk of Postop Cognitive Dysfunction After Colorectal Surgery,This study aimed to identify risk factors for early postoperative cognitive dysfunction in elderly patients undergoing colorectal cancer surgery.
  March 2019 ,Arthritis Research & Therapy,Tophus Resolution in Patients With Chronic Refractory Gout,A new study examines the rate of tophus resolution among gout patients treated with pegloticase.
  March 2019 ,Current Opinion in Psychiatry,Stem Cell Therapies for Alzheimer's Disease: Is It Time?,"Stem cell therapy has shown promise as a potential treatment for Alzheimer's disease patients, but more research is needed. How close are we?"
  March 2019 ,Circulation,Status of Renal Denervation Therapy for Hypertension,"Is renal denervation a viable option to treat resistant hypertension? A new study is encouraging, but the jury is still out."
  March 2019 ,European Heart Journal,Transcatheter Heart Valve Interventions: Where Are We?,"While percutaneous approaches have transformed management of valvular heart disease, more knowledge is needed to ensure optimal patient outcomes."
  March 2019 ,Journal of Viral Hepatitis,Viral Load and Efficacy of Elbasvir/Grazoprevir for HCV,More patients with HCV genotype 1a infection may be able to receive 12 rather than 16 weeks of elbasvir/grazoprevir after baseline resistance testing.
  March 2019 ,Rheumatology,Recent Developments in Biologic Therapies for SLE,Get up-to-date on the latest biologic treatment options available for systemic lupus erythematosus patients.
  March 2019 ,Translational Andrology and Urology,Active Surveillance for Non-Muscle Invasive Bladder Cancer,What is the current state of knowledge concerning the use of active surveillance for low grade non-muscle invasive bladder cancer?
  March 2019 ,Schizophrenia Bulletin,Sleep Disorders in Early Psychosis,This study examined the prevalence and characteristics of clinical sleep disorders in patients experiencing early psychosis.
  March 2019 ,Neurosurgical Focus,Predictive Models for Patient-reported Spine Surgery Outcomes,"This study evaluated predictive models for patient-reported outcomes in elective degenerative spinal surgery with respect to study design, accuracy, reliability, variance, and utility."
  March 2019 ,Alimentary Pharmacology & Therapeutics,"Donor Features, Procedures and Outcomes in Fecal Transplant","This comprehensive review examined donor characteristics and screening protocols for fecal microbiota transplantation, as well as FMT procedures and outcomes."
  March 2019 ,The British Journal of Dermatology,Infliximab and Risk of Serious Infection in Psoriasis,Does infliximab increase the risk of serious infection as compared to nonbiologic systemic therapies in patients with psoriasis?
  March 2019 ,Clinical Endocrinology,Menstrual Function in PCOS After Behavioral Modification,A behavioral modification program may help improve menstrual regularity among overweight women with PCOS.
  March 2019 ,Headache,Oxygen and Other Acute Treatments for Cluster Headache,Results from an international survey provide insight into the effectiveness and side effects associated with oxygen and other options for the acute treatment of cluster headache.
  March 2019 ,European Heart Journal,Defibrillator Therapy for Non-Ischemic Cardiomyopathy,Treatment for non-ischemic cardiomyopathy should not be 'one size fits all.'
  March 2019 ,Journal of the American Geriatrics Society,Cataract and Risks of Osteoporosis and Fracture,Are individuals with cataract at higher risks of osteoporosis and fracture than those without?
  March 2019 ,American Journal of Transplantation,Drug Safety and Tolerability in New Transplant Therapies,A new position statement from the Transplant Therapeutics Consortium stresses the importance of considering the safety and tolerability of new therapeutic options for transplant patients.
  March 2019 ,Alimentary Pharmacology & Therapeutics,Vedolizumab Levels and Outcomes in Ulcerative Colitis,"This study aimed to characterize the relationship between vedolizumab exposure and response in ulcerative colitis, adjusted for variables known to affect drug clearance and serum concentration."
  March 2019 ,Journal of Viral Hepatitis,Antivirals for Blocking Mother-to-Child Transmission of HBV,Is lamivudine as effective as tenofovir disoproxil fumarate for preventing mother-to-child transmission of HBV?
  March 2019 ,Current Opinion in Allergy and Clinical Immunology,Severe Asthma in Children: Therapeutic Considerations,Which factors should be considered before escalating treatments in children with severe therapy-resistant asthma?
  March 2019 ,Circulation,Classification of Deaths in Cardiovascular Outcomes Trials,"How common are undetermined cause of deaths in cardiovascular outcomes trials, and what are the implications of these findings?"
  March 2019 ,Annals of Oncology,Dosing Adjuvant Chemo in Breast Cancer: Focus on Obesity,Chemotherapy overdose may be avoided in obese patients with breast cancer using a tailored dosing strategy.
  March 2019 ,Alimentary Pharmacology & Therapeutics,Aminosalicylate Use in Patients With UC on Biologics,"Is it efficacious and cost-effective to continue aminosalicylates in patients with ulcerative colitis who have been escalated to immunosuppressants, biologics, or oral small molecules?"
  March 2019 ,The British Journal of Dermatology,Brodalumab as an Alternative to Ustekinumab in Psoriasis,Is brodalumab effective in treating moderate-to-severe psoriasis in patients who do not achieve adequate response with ustekinumab?
  April 2019 ,Current Orthopaedic Practice,Study Designs for Surgical Interventions in Cerebral Palsy,Certain study designs used in cerebral palsy research may impact the validity of the extracted evidence. Should alternative study designs be considered?
  April 2019 ,Clinical Endocrinology,Hormonal Contraception and Peak BMD Accrual in Adolescents,In what ways might the use of combined hormonal contraceptives impact BMD accrual among adolescents?
  April 2019 ,Anesthesia & Analgesia,"Gabapentin and Pregabalin for Pain in Children, Adolescents",What is the current evidence for the safety and efficacy of gabapentin and pregabalin for neuropathic and postoperative pain in children and adolescents?
  April 2019 ,Journal of Oncology Practice,Oral Anticancer Therapy: Management of Drug Interactions,This in-depth review summarizes notable DDIs associated with TKIs and other oral anticancer agents and provides evidence-based management strategies.
  April 2019 ,HIV Medicine,"Depression, Lifestyle Factors and Cognitive Function in HIV",How does cognitive function differ between HIV-positive and HIV-negative individuals -- and what role might depressive symptoms and lifestyle factors may play in these differences?
  April 2019 ,American Journal of Cardiovascular Drugs,Emerging Drugs for Residual CV Risk in Statin-Treated Adults,Learn about the many novel therapeutics recently approved or under development which target LDL-C and/or triglycerides via different mechanisms than do statins.
  April 2019 ,Journal of Viral Hepatitis,Glecaprevir/Pibrentasvir in Chronic HCV Genotype 3 Infection,Is glecaprevir/pibrentasvir effective in patients with chronic HCV genotype 3 infection and compensated cirrhosis?
  April 2019 ,Endocrine Practice,Efficacy and Safety of IDegLira in Older Patients With T2D,IDegLira is an insulin degludec/liraglutide combination that has been shown to improve glycemic control in type 2 diabetes. Is it a safe and effective option for older patients?
  April 2019 ,Southern Medical Journal,Menstruation and QoL in Women With Sickle Cell Disease,"This study aimed to elucidate the clinical features of menstruation in young women with sickle cell disease, and their impact on quality of life."
  April 2019 ,Journal of Medical Case Reports,Strategy for Treatment of Stage IV HER2+ Gastric Cancer,"This case presents a patient successfully treated with a novel strategy for stage IV HER2-positive gastric cancer, which usually has a poor prognosis."
  April 2019 ,Arthritis Research & Therapy,HRQoL in Giant Cell Arteritis Treated With Tocilizumab,How might the addition of tocilizumab impact health-related quality of life among giant cell arteritis patients?
  April 2019 ,Journal of the American Academy of Orthopaedic Surgeons,Medial Unicompartmental Arthroplasty of the Knee,"Learn more about the benefits of medial unicompartmental knee arthroplasty, how to identify suitable surgical candidates, and how it compares with total knee arthroplasty."
  April 2019 ,Journal of Clinical Endocrinology & Metabolism,GH Dosing and Prepubertal Height Velocity in Short Children,Prepubertal children with short stature who receive a reduced dose of GH may be able to maintain a normal height velocity.
  April 2019 ,Wounds,Studies of Hyaluronic Acid in Wound Care,Does a review of current literature support the use of esterified hyaluronic acid in the treatment of difficult or chronic wounds?
  April 2019 ,The British Journal of Dermatology,Atopic Dermatitis: The Skin Barrier and Beyond,"This review sheds light on the complex pathophysiology of atopic dermatitis, encompassing genetic risk factors, environmental triggers, skin barrier disruption, and immunological dysfunction."
  April 2019 ,Annals of Oncology,NGS in Lung Cancers With Insufficient Tumor Samples,How effective is next-generation sequencing of ctDNA for detection of actionable variants in advanced lung cancer?
  March 2019 ,Translational Lung Cancer Research,Predictive Markers for Anti-PD-1/PD-L1 Therapy in NSCLC,What is the current outlook for using predictive markers to guide treatment for patients with NSCLC? What challenges face laboratories implementing these tests?
  March 2019 ,Breast Cancer Research,Adipocytes Promote Breast Cancer Resistance to Chemotherapy,Adipocytes may play a role in resistance to doxorubicin. Could this be one reason why obesity is associated with chemoresistance?
  March 2019 ,Journal of the American Geriatrics Society,Pharmacotherapy in Older Adults With Cardiovascular Disease,Review the recommendations of a recent multidisciplinary workshop focused on determining top priority areas for research to optimize pharmacotherapy in older adults with cardiovascular disease.
  March 2019 ,Pain,Facial Muscle Movements Encoding Pain,"While pain expressions differ among individuals, some facial movements, like opening of the mouth, often indicate pain."
  April 2019 ,Arthritis Research & Therapy,Anti-Neutrophil Cytoplasmic Antibodies in Systemic Sclerosis,A new study examines the clinical associations of anti-neutrophil cytoplasmic antibodies in systemic sclerosis. What have we learned?
  April 2019 ,Journal of Clinical Endocrinology & Metabolism,"Saturated Fat, Inflammation, and Insulin Resistance in PCOS",In what ways might saturated fat impact inflammation and insulin resistance in PCOS?
  April 2019 ,BMC Pulmonary Medicine,HRQoL Varies in Different Respiratory Disorders,How does health related quality of life vary between several different respiratory diseases? A new study provides insight.
  April 2019 ,Annals of Surgery,The Role of Bowel Preparation in Colorectal Surgery,What role does bowel preparation play in reducing the risk of infectious complications in colorectal procedures? Is the combined use of mechanical and antibiotic preparation the best option?
  April 2019 ,The British Journal of Dermatology,OCT for Diagnosis of Basal Cell Carcinoma,"This review explores how optical coherence tomography, a noninvasive near-infrared light imaging technology, might improve the diagnosis and management of basal cell carcinoma."
  April 2019 ,Annals of Oncology,Implication of Residual TILs in TNBC After Neoadjuvant Chemo,Do residual disease tumor-infiltrating lymphocyte levels help predict survival after neoadjuvant chemotherapy for TNBC?
  April 2019 ,Clinical Endocrinology,Immunosuppressants and Less Steroids in Graves' Orbitopathy,Could combined immunosuppressive therapy help reduce steroid doses in graves' orbitopathy?
  April 2019 ,The Gerontologist,Cognitive Complaints in Memory Clinic and Depressive Patients,"How do cognitive complaints differ among cognitively normal older adults, memory clinic patients, and patients with depression; and which are suggestive of prodromal Alzheimer disease?"
  April 2019 ,Skin Therapy Letter,Immunotherapeutics in the Management of Metastatic Melanoma,Advances in immunotherapeutics in the last decade have drastically changed the outlook for patients with metastatic melanoma. Review the currently available immunotherapies in this update.
  April 2019 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Changing ART in Pregnancy and Impact on Viral Suppression,A new study examines the question of whether changing ART during early pregnancy affects virological outcomes.
  April 2019 ,Alimentary Pharmacology & Therapeutics,Epidemiology and Response to DAA Therapy in Genotype 6 HCV,A new review provides insight into the epidemiology and virologic outcome of direct-acting antiviral regimens in HCV genotype 6 patients.
  April 2019 ,Rheumatology,Predicting Flare Risk After Stopping Adalimumab in RA,A new study examines the question of whether adalimumab trough and antidrug antibody levels predict flare among rheumatoid arthritis patients who have stopped adalimumab.
  April 2019 ,Journal of Clinical Endocrinology & Metabolism,Mindfulness Improves Eating Behavior and Weight Loss,A new study examines the beneficial effects of mindfulness-based eating behavior strategies among patients who attended an obesity service.
  April 2019 ,Anesthesiology,Blood Pressure Perturbations after Abdominal Surgery,"This study found that potentially serious postoperative hypotension or hypertension is common after abdominal surgery, and often goes undetected."
  April 2019 ,Neurosurgical Focus,Functional Outcomes in Combat-related Penetrating Brain Injury,This study aimed to characterize the long-term outcomes of military personnel who sustain combat-related penetrating brain injury. What clinical characteristics led to worse functional outcomes?
  April 2019 ,BMC Pulmonary Medicine,Hyperoxia Effects on Mortality in Critically Ill Patients,Is there an association between hyperoxia and increased mortality among patients admitted to the ICU?
  April 2019 ,Pain,Cannabis for Chronic Pain in Patients With Fibromyalgia,This experimental study explored the pharmacokinetics and pharmacodynamics of cannabis in chronic pain patients with fibromyalgia. How did it fare in reducing pain compared with placebo?
  April 2019 ,Liver International,Causality Between NAFLD and Risk of CVD and Type 2 Diabetes,This study explores the evidence for a possible causal relationship between non-alcoholic fatty liver disease and type 2 diabetes or cardiovascular disease.
  April 2019 ,The British Journal of Dermatology,Interventions for Infantile Hemangiomas of the Skin,Infantile hemangiomas can become problematic or cause mental distress to children and parents. Which treatments are most effective?
  April 2019 ,JCO Precision Oncology,Durable Response of Checkpoint Inhibitors vs Other Therapies,Patients receiving immune checkpoint inhibitors may experience durable response over two times more frequently than those receiving other drug classes.
  April 2019 ,Journal of Clinical Endocrinology & Metabolism,Anabolic Steroid Use and Body Image Disorders in Young Men,"The use of anabolic-androgenic steroids among young men is on the rise, despite regulatory efforts and reported adverse health effects. What can be done to stem the epidemic?"
  April 2019 ,Translational Andrology and Urology,Role of Biomarkers in Non-Muscle Invasive Bladder Cancer,"Preliminary evidence shows the promising potential of circulating biomarkers in the diagnosis, staging, and monitoring of non-muscle invasive bladder cancer."
  April 2019 ,Breast Cancer Research,AMP-Activated Protein Kinase: Potential Target for TNBC,"Metformin, fluoxetine, and other AMPK agonists significantly inhibit TNBC. Will targeted therapy finally become an option for this aggressive disease?"
  April 2019 ,Journal of the National Cancer Institute,Barriers to Cancer Clinical Trial Participation,"Despite all the potential benefits associated with cancer research, why aren't more patients participating in clinical trials?"
  April 2019 ,Journal of the American Geriatrics Society,Polypharmacy and Outcome in Patients on Vitamin K Antagonists,What impact does polypharmacy have on the quality and outcome of anticoagulation therapy with Vitamin K antagonists?
  April 2019 ,Pain,Flunarizine as Prophylaxis for Episodic Migraine,"Although not approved in the US, the calcium channel blocker flunarizine has been used for 30 years as a prophylactic drug in migraine. This meta-analysis examined its safety and efficacy."
  April 2019 ,Alimentary Pharmacology & Therapeutics,Detection and Management of DILI in NASH Clinical Trials,This paper provides a framework for the approach to assessment and management of suspected acute drug-induced liver injury during clinical trials in patients with NASH.
  April 2019 ,Anesthesiology,Lung- and Diaphragm-protective Ventilation in ARDS,"The authors of this paper propose a novel approach to mechanical ventilation in the ICU, integrating both lung-protective and diaphragm-protective considerations."
  April 2019 ,Critical Care,The Safety of Vasopressin Receptor Agonists in Septic Shock,What do we currently know about the effects and safety of vasopressin receptor agonists in septic shock patients?
  April 2019 ,Alimentary Pharmacology & Therapeutics,"Metabolomic Profiles in IBS, UC, and Healthy Controls",This study aimed to determine whether urinary metabolite profiles might be useful for differentiating IBS patients from healthy controls and IBD patients.
  April 2019 ,U.S. Pharmacist,Management of Acute Ischemic Stroke: Guideline Updates,This paper summarizes 2018 guidelines by the American Heart Association/American Stroke Association outlining optimal treatment for early management of patients with acute ischemic stroke.
  April 2019 ,Clinical Endocrinology,Effects of Carbohydrate Restriction in Prader-Willi Syndrome,A new study compares the concentrations of hormones and metabolites among Prader-Willi children who consumed either a low carbohydrate or a low-fat diet. How did they differ?
  April 2019 ,Medicine and Science in Sports and Exercise,Morning vs Evening Aerobic Training Effect on Blood Pressure,Might the time of day influence the hypotensive effect of aerobic training?
  April 2019 ,Current Opinion in Nephrology and Hypertension,New Therapies for Hyperkalemia,Learn more about the emerging new therapies for the management of hyperkalemia.
  April 2019 ,Current Opinion in Psychiatry,Management of Antipsychotic-Induced Tardive Dyskinesia,"Newer generation antipsychotics have reduced, but not eliminated, the risk of antipsychotic-induced tardive dyskinesia. What are the best management options for this debilitating adverse effect?"
  April 2019 ,AIDS,Clinical Trials of ART Interruption in HIV-Infected People,What have we learned from recent HIV clinical studies regarding antiretroviral treatment interruption?
  April 2019 ,Southern Medical Journal,A Brief Review of the Pharmacology of Hyperkalemia,"This article reviews the pathophysiology and common causes of both acute and chronic hyperkalemia, and summarizes the many approaches to treatment of this electrolyte abnormality."
  April 2019 ,Journal of the American Board of Family Medicine,The Burden of Childhood Atopic Dermatitis in the PC Setting,"This study sought to determine the prevalence of atopic dermatitis in children attending primary care, and describe skin care practices used by parents on their children both with and without AD."
  April 2019 ,Pediatric Pharmacotherapy,Baloxavir Marboxil: A Flu Antiviral With a Novel Mechanism,Baloxavir marboxil is a newly approved treatment for influenza. Learn more about the antiviral mechanism of action of this agent.
  April 2019 ,BMC Oral Health,The Effects of EMONO in Pediatric Dentistry,"This study examined the effects and acceptability of EMONO, an equimolar mixture of oxygen and nitrous oxide, when used in dental care for infants, children and adolescents."
  May 2019 ,Spine,Practice Variation in Lumbar Spinal Stenosis Treatment,"When it comes to the diagnosis and treatment of lumbar spinal stenosis, how do surgeons' practices differ?"
  May 2019 ,Annals of Oncology,Irradiation to Contralateral Breast for BRCA+ Breast Cancer,What role does contralateral breast irradiation have in women with early BRCA+ breast cancer who have declined contralateral mastectomy?
  May 2019 ,Breast Cancer Research,Value of Androgen Receptor Expression in ER+ Breast Cancer,Does androgen receptor expression predict response to tamoxifen in women with ER+ breast cancers?
  May 2019 ,Journal of the National Cancer Institute,Premature Aging in Young Cancer Survivors,Cancer survivors are more likely to experience cardiovascular disease and other chronic health conditions as a result of premature aging. What can be done?
  May 2019 ,HIV Medicine,Neonatal Prophylaxis and Hematologic Toxicity in Infants,Is the use of combination neonatal prophylaxis associated with the risk of severe hematologic adverse events?
  May 2019 ,Journal of the Endocrine Society,High Cortisol/DHEA-S Ratio Is a Risk Factor for Sarcopenia,"In this study, a high cortisol/DHEA-S ratio was shown as a strong risk factor for sarcopenia among elderly patients with type 2 diabetes."
  May 2019 ,Alimentary Pharmacology & Therapeutics,VOCs Emitted From Feces as a Biomarker for Colorectal Cancer,Could specific volatile organic compounds given off from feces serve as biomarkers for colorectal cancer?
  May 2019 ,Rheumatology,70th Anniversary of Glucocorticoids in Rheumatic Diseases,"The introduction of glucocorticoids marked a breakthrough in the treatment of inflammatory conditions, but the high doses and adverse effects were concerning. Are they ready for a comeback?"
  May 2019 ,Alimentary Pharmacology & Therapeutics,Machine Learning Model to Predict Recurrent Ulcer Bleeding,The authors present a novel clinical and laboratory parameter-based prediction model to predict recurrent ulcer bleeding in patients with a history of H. pylori-negative idiopathic bleeding ulcers.
  May 2019 ,The British Journal of Dermatology,Cryosurgery Plus Topical Interventions for Actinic Keratosis,Is a combination of cryosurgery with a topical intervention superior to cryosurgery alone for treatment of actinic keratoses?
  May 2019 ,Journal of the American Geriatrics Society,"CPAP Adherence and Cognitive Decline in Adults With MCI, OSA",This study demonstrated a beneficial effect of CPAP adherence on multiple domains of cognitive function in persons with mild cognitive impairment and obstructive sleep apnea.
  May 2019 ,Nephrology Dialysis Transplantation,eResearch in Acute Kidney Injury: A Primer for EHR Research,Learn more about the role of eResearch and EHR data in acute kidney injury research.
  May 2019 ,Alimentary Pharmacology & Therapeutics,Drug-Induced Liver Injury by Sevoflurane and Desflurane,Have modern volatile anesthetics reduced the incidence of drug-induced liver injury compared to that reported with older agents?
  May 2019 ,BMC Anesthesiology,Postoperative Delirium in Critically Ill Surgical Patients,The authors developed a prediction model for identifying patients at high risk for postoperative delirium.
  May 2019 ,American Journal of Clinical Dermatology,Cannabinoids in Inflammatory and Neoplastic Skin Diseases,The endocannabinoid system is responsible for maintaining many aspects of skin homeostasis. How might cannabinoids be of value for treatment of various inflammatory and neoplastic skin diseases?
  April 2019 ,Journal of the American Academy of Orthopaedic Surgeons,OITE Performance and Research Productivity Among Residents,Which factors may predict whether a candidate will perform well on the OITE -- or who will be more likely to continue research during residency?
  April 2019 ,Alimentary Pharmacology & Therapeutics,IBD: Optimized Infliximab Monotherapy vs Combination Therapy,This study compared the clinical efficacy and cost of two different IBD treatment strategies for the introduction of infliximab: 6-12 months in combination with azathioprine versus optimized monotherapy.
  April 2019 ,Menopause,Complications Following Vaginal Laser Treatment for Atrophy,Is laser therapy safe and effective for treating genitourinary syndrome of menopause? This paper presents four cases with complications due to unapproved use of lasers for vaginal symptoms.
  April 2019 ,The British Journal of Dermatology,Adverse Effects of Topical Photodynamic Therapy,"While topical photodynamic therapy is a widely used and generally well tolerated treatment, there can be adverse effects. What are the most common, and how are they best managed?"
  April 2019 ,Current Opinion in Ophthalmology,Advances in Dry Eye Disease Treatment,"Get up-to-date on the latest treatments available for dry eye disease including new medications, procedures, and device options."
  May 2019 ,BMC Oral Health,The Antiplaque/Anticariogenic Efficacy of Salvadora persica,"The botanical Salvadora persica, also known as miswak, has long been used in oral hygiene. Does it compare favorably to chlorhexidine in reducing plaque and cariogenic bacteria?"
  May 2019 ,BMC Anesthesiology,A Novel Approach to Neuraxial Anesthesia Using Ultrasound,The authors present a novel intelligent image processing system that identifies spinal landmarks using ultrasound images to guide neuraxial block.
  May 2019 ,Alimentary Pharmacology & Therapeutics,A Risk Score for Predicting Major Acute CV Events in NAFLD,The authors developed a novel risk score which incorporates mean platelet volume to accurately predict 1-year risk of major acute cardiovascular events in patients with NAFLD.
  May 2019 ,Liver International,AF: Highly Prevalent Yet Undertreated in Patients With NASH,This study found that the prevalence of atrial fibrillation in patients with NASH is twice that of the general population. Are these patients receiving appropriate anticoagulation therapy?
  May 2019 ,Annals of Family Medicine,Signs and Symptoms for the Diagnosis of Acute Rhinosinusitis,What are the key indicators which most accurately identify those patients with clinically suspected sinusitis who actually have acute bacterial rhinosinusitis?
  May 2019 ,Pediatric Pharmacotherapy,Methylphenidate Capsules for Morning ADHD Symptom Control,Newly approved delayed- and extended-release methylphenidate capsules designed for bedtime administration may provide better early morning symptom control for ADHD patients.
  May 2019 ,Europace,Cardiac MRI in Patients With Cardiac Resynchronization Therapy,Would keeping resynchronization therapy active during MRI in patients with cardiac resynchronization therapy improve results? This article presents a strategy for conducting high quality scans safely.
  May 2019 ,Journal of the American Board of Family Medicine,Training Vulnerable PC Patients to Use a Patient Portal,"This study tested the effectiveness of delivering online, video-based portal training to primary care patients with limited health literacy."
  May 2019 ,Journal of the American Geriatrics Society,Action Steps for Older Adults With Multiple Chronic Conditions,The AGS presents a framework of actions and accompanying action steps for decision making for clinicians who provide both primary and specialty care to older people with multiple chronic conditions.
  May 2019 ,Anesthesiology,Perioperative Fluid Therapy for Major Surgery,"This article reviews the latest evidence on preoperative and intraoperative IV fluid therapy for major surgery, reviewing different strategies as well as type and volume of fluids."
  May 2019 ,Pain,Extended-release Gabapentin for Failed Back Surgery Syndrome,Is extended-release gabapentin efficacious for persistent pain after lumbar surgery?
  May 2019 ,The Gerontologist,Factors Affecting Older Adults' Hospital-to-Home Transition,This study aimed to identify and elucidate the performance-shaping factors which contribute to older adults' successful hospital-to-home transitions.
  May 2019 ,Alimentary Pharmacology & Therapeutics,Glecaprevir/Pibrentasvir for Treatment of Chronic HCV,The study evaluated the effectiveness and safety of glecaprevir/pibrentasvir under real-world conditions in adult patients with chronic HCV infection.
  May 2019 ,European Heart Journal,Cardiac Stem Cells in the Post-Anversa Era,Recent investigations have discredited much of the literature supporting c-Kit+ cardiac stem cells having any role in cardiac repair. Where do we go from here?
  May 2019 ,Clinical Endocrinology,Growth Hormone Therapy and Short Stature-Related Distress,In what ways might growth hormone therapy impact the psychosocial well-being of children with short stature?
  May 2019 ,Skin Therapy Letter,Glycopyrronium Tosylate (Qbrexza) for Hyperhidrosis,Topical glycopyrronium tosylate was recently FDA-approved to manage patients with primary axillary hyperhidrosis. Review the clinical trial results in this article.
  May 2019 ,Alimentary Pharmacology & Therapeutics,Post-op Complications With Pre-op Anti-TNF Agents for CD,Does pre-operative exposure to anti-TNF agents increase the risk for post-operative infectious complications in patients with Crohn's disease?
  May 2019 ,Liver International,When Is Stopping Immunosuppressives in AIH Justified,"How long should immunosuppressive treatment of autoimmune hepatitis be continued, and which patients are suitable for drug withdrawal?"
  May 2019 ,European Heart Journal,Tafamidis for Transthyretin Amyloid Cardiomyopathy,A new drug for the treatment of transthyretin cardiomyopathy looks to be a game-changer; but will it benefit all TTR patients?
  May 2019 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Metabolic Syndrome and Neurocognitive Deficits in HIV,Is there a link between metabolic syndrome and neurocognitive impairment? What role might these conditions have in HIV?
  June 2019 ,Journal of Clinical Oncology,Survival With Pembrolizumab for Melanoma and Brain Mets,Does pembrolizumab show activity against melanoma brain metastases? Are responses durable?
  June 2019 ,Pain,Navigating Trials of Personalized Pain Treatments,"To efficiently evaluate the treatment effect of personalized pain treatment strategies, subgroup differences must be identified and considered in clinical trials."
  June 2019 ,Critical Care Medicine,Frequency of Screening for Mechanical Ventilation Weaning,How often should ventilated patients be screened for possible weaning?
  June 2019 ,Journal of Oncology Practice,Don't Forget Radiotherapy for These Patients With Lymphoma,Radiation therapy has a critical role in the management of lymphoma. Are you missing any of these opportunities to improve patient outcomes?
  June 2019 ,Liver International,HCV Late Relapse in Patients With DAA-related SVR at Week 12,"What are the clinical, epidemiological and virological features of patients who experience late relapse after successful treatment with direct-acting antivirals?"
  May 2019 ,Arthritis Research & Therapy,Long-Term Safety and Efficacy of ABP 501 in Patients With RA,How does the safety and efficacy of the adalimumab biosimilar ABP 501 compare with that of the reference product?
  May 2019 ,Journal of Clinical Oncology,Allogeneic HCT Provides No Benefit for Hypodiploid ALL,Is HCT still indicated for pediatric patients with hypodiploid ALL? New reports call this practice into question.
  May 2019 ,Translational Lung Cancer Research,Using Stereotactic Body Radiation Therapy With Immunotherapy,Learn about ongoing clinical trials and the potential for clinical synergy between radiation and immunotherapy.
  May 2019 ,Journal of Viral Hepatitis,Response to HCV Treatment by PWID in Needle & Syringe Program,This study aimed to assess whether people who actively inject drugs can be recruited and treated successfully through a community needle and syringe program.
  May 2019 ,Current Opinion in Ophthalmology,Precision Medicine to Prevent Glaucoma-Related Blindness,How might the principles of precision medicine apply to the prevention and management of glaucoma-related blindness?
  May 2019 ,BMC Anesthesiology,Postoperative Analgesia for Pediatric Craniotomy Patients,What is the optimal regimen for postoperative analgesia in pediatric neurosurgery patients?
  May 2019 ,American Journal of Cardiovascular Drugs,Cardiovascular Protection With Anti-Hyperglycemic Agents,Anti-hyperglycemic drugs are commonly used in the treatment of diabetes. Could certain agents provide cardiovascular benefits as well?
  May 2019 ,Alimentary Pharmacology & Therapeutics,The Nocebo Effect in Biosimilar-treated IBD Patients,"While biosimilars have been shown to be effective and safe in treating IBD, some patients may experience the nocebo effect. How can the negative impact of this effect be prevented or reduced?"
  May 2019 ,Annals of Oncology,Application of SMART Trial Design in Older Patients With CLL,Can a clinical trial in which treatment decisions are guided by intermediate patient outcomes be used in cancers?
  May 2019 ,American Journal of Public Health,"Trends in Yoga, Tai Chi, and Qigong Use Among US Adults","This study examined trends in the prevalence, patterns of use, and predicting factors of the mind-body therapies yoga, tai chi, and qigong among US adults."
  May 2019 ,Journal of the National Cancer Institute,Surveillance After Treatment of Localized Breast Cancer,Is it time to bring circulating tumor cell assays to the forefront of breast cancer surveillance?
  May 2019 ,Alimentary Pharmacology & Therapeutics,Combined Immunosuppression in Adults >60 With Crohn's Disease,Older adults with Crohn's disease have tended to be treated less aggressively than younger patients. Is a treatment strategy of combined immunosuppression safe and effective in those 60 and over?
  May 2019 ,Rheumatology,Managing Inflammatory Rheumatic Conditions in the Elderly,What special considerations should be taken when managing elderly patients with chronic inflammatory rheumatic diseases?
  May 2019 ,BMC Pulmonary Medicine,COPD Exacerbations Associated With Biomass vs Tobacco Smoke,Might the risk of acute COPD exacerbations differ between biomass smoke and tobacco smoke exposure? In what ways?
  May 2019 ,Headache,ADAM Zolmitriptan for Difficult-to-Treat Migraine,"This study evaluated the efficacy and potential for adverse effects of a novel, investigational intracutaneous drug delivery system for zolmitriptan when used for refractory migraine headache."
  June 2019 ,Human Reproduction,The Sexual Activity Questionnaire in Endometriosis,What can this tool tell us about the sexual quality of life among women being treated for endometriosis?
  June 2019 ,Current Opinion in Rheumatology,Psoriatic Spondylitis or Ankylosing Spondylitis Psoriasis,"A new review examines the similarities and differences between these conditions, and explores the implications for treatment."
  June 2019 ,Journal of Viral Hepatitis,OBV/PTV/r +/- DSV +/- RBV in HCV With Diverse Comorbidities,"Does real-world evidence confirm the effectiveness of OBV/PTV/r +/- DSV +/- RBV in patients with HCV GT1 or GT4, and how do comorbidities or comedications impact outcomes?"
  June 2019 ,Alimentary Pharmacology & Therapeutics,Lactobacillus rhamnosus GG for Gastroenteritis in Children,Is L rhamnosus GG a safe and effective treatment option for acute gastroenteritis in children?
  June 2019 ,Current Opinion in Urology,Urinary Biomarkers in Bladder Cancer: Where Do We Stand?,Could urinary biomarkers play a role in the diagnostic workup for bladder cancer?
  June 2019 ,Arthritis Research & Therapy,Safety and Efficacy of Tofacitinib in the Treatment of RA,Is tofacitinib a safe and effective therapeutic option for patients with rheumatoid arthritis?
  June 2019 ,Annals of Family Medicine,A New Measure of High-Value Aspects of Primary Care,Find out more about a newly developed primary care measure for identifying the aspects of care that provide the most value.
  June 2019 ,Journal of the American Geriatrics Society,Survival in Older Adults With Metastatic Colorectal Cancer,This paper describes current real-life first-line treatment approaches in older patients with metastatic colorectal cancer. How does survival vary by approach?
  June 2019 ,European Heart Journal,Cerebral Embolic Protection During TAVI,What have we learned about the use of embolic cerebral protection devices to prevent peri-procedural stroke?
  June 2019 ,BMC Pulmonary Medicine,Negative Impact of Anorexia and Weight Loss on IPF Treatment,In what ways might anorexia and weight loss impact treatment outcomes among IPF patients switching from pirfenidone to nintedanib?
  June 2019 ,Journal of Clinical Oncology,Nivolumab for Relapsed/Refractory DLBCL,Does the PD-1 blocking antibody nivolumab offer a survival advantage for patients with relapsed or refractory DLBCL?
  June 2019 ,JCO Precision Oncology,Precision Oncology in Sarcomas: Divide and Conquer,How is next-generation sequencing changing the landscape of diagnosis and treatment of sarcoma?
  June 2019 ,American Journal of Clinical Pathology,Stratification of Follicular Lymphoma,Has a newly proposed alternative method introduced a new paradigm in the way we approach the grading of follicular lymphoma?
  June 2019 ,Journal of Viral Hepatitis,Ruzasvir Plus Uprifosbuvir for 12 Weeks in Chronic HCV,"This study indicates that the combination of ruzasvir 60 mg plus uprifosbuvir 450 mg once daily for 12 weeks is well tolerated overall, but effective only for certain HCV genotypes."
  June 2019 ,BMC Anesthesiology,Problems With Patient Monitoring Reported by Anesthesiologists,What are the most common problems that anesthesiologists face in patient monitoring? This survey reveals several issues not previously identified as problematic in real-life patient care.
  June 2019 ,Liver International,Outcomes in HBV-related Acute on Chronic Liver Failure,This study compared the 5-year survival rate and incidence rate of hepatocellular carcinoma between patients with HBV-related acute on chronic liver failure and HBV cirrhosis.
  June 2019 ,Journal of the National Cancer Institute,Palbociclib and Endocrine Therapy for Advanced Breast Cancer,An analysis of longer-term PALOMA safety data finds that palbociclib plus endocrine therapy is not associated with specific cumulative or delayed toxicities.
  June 2019 ,Brain,Survival: The Ultimate Long-term Outcome in MS,New research supports that disease-modifying therapy for multiple sclerosis is effective in the 'real world.'
  June 2019 ,Journal of the American Geriatrics Society,Immune Checkpoint Inhibitors in Older Adults With NSCLC,This study evaluated the efficacy and toxicity of immune checkpoint inhibitors in patients 70 and older with advanced NSCLC seen in routine clinical practice.
  June 2019 ,BMC Pulmonary Medicine,Supporting Medication Adherence for Cystic Fibrosis,What strategies can clinicians use to encourage medication adherence in their cystic fibrosis patients?
  June 2019 ,Emerging Infectious Diseases,Mycobacterium obuense Bacteremia in a Patient With Pneumonia,"A case of bacteremia in a patient with community-acquired pneumonia shows the potential pathogenicity of M. obuense, a mycobacterium thought to be nonpathogenic."
  June 2019 ,Arthritis Research & Therapy,Withdrawal of Infliximab Therapy in Ankylosing Spondylitis,Should infliximab withdrawal be considered for ankylosing spondylitis patients who have achieved clinical remission? What are the effects of reintroduction?
  June 2019 ,Chinese Clinical Oncology,Tumor Microenvironment and Pancreatic Cancer Therapy,Chemoresistance and radioresistance are common in pancreatic ductal adenocarcinoma. Do pharmacologic agents address these challenges?
  June 2019 ,Journal of the National Cancer Institute,Association of Aspirin and NSAIDs With CRC Risk by Subtypes,Patients who take aspirin and NSAIDs regularly may have a reduced risk of microsatellite instability-high colorectal cancer without BRAF or KRAS mutation.
  June 2019 ,Current Opinion in Ophthalmology,Descemet's Stripping Without Endothelial Keratoplasty,Is this procedure a safe and effective surgical option for Fuchs' Dystrophy? This review provides insight into the clearance rates and outcomes of this technique.
  June 2019 ,Annals of Surgery,"Surgery, Complications, and Quality of Life",A better understanding of the psychosocial impacts on quality of life following a surgical complication will help surgeons better support postoperative patients.
  June 2019 ,BMC Pulmonary Medicine,Pulmonary Rehabilitation After Bronchiectasis Exacerbation,A new study examines the effects of post-exacerbation pulmonary rehabilitation in bronchiectasis. Are there any benefits?
  June 2019 ,Critical Care,Comparative Efficacy of Vasoactive Drugs in Septic Shock,How do different kinds of vasoactive medications compare in terms of mortality and adverse events?
  June 2019 ,Headache,Post-treatment Effect of Galcanezumab in Migraine,"Does galcanezumab, which has a long half-life of 27 days, demonstrate persistence of response or of adverse events after migraine treatment cessation?"
  June 2019 ,European Heart Journal,Trusting Observational Data for Clinical Decision-making,This commentary uses the CLARIFY study as an example which raises a crucial question: how should data from observational studies be applied to the clinical care of patients?
  June 2019 ,Brain,The Debated Toxic Role of Aggregated TDP-43 in ALS,TDP-43 may play a major role in the neurodegeneration associated with ALS. Review the latest on TDP-43 including its structural and intrinsic characteristics.
  June 2019 ,Journal of the American Geriatrics Society,Function in Older Women With BC on Adjuvant Chemotherapy,This study provides insight into potential risk factors for functional decline and lack of resilience in older women receiving adjuvant chemotherapy for breast cancer.
  June 2019 ,AIDS,Effectiveness of INSTIs Among Treatment-Experienced Patients,How effective are integrase strand transfer inhibitor-based regimens among HIV patients who are ART-experienced?
  June 2019 ,Seminars in Respiratory and Critical Care Medicine,Optimal Ventilator Strategies in ARDS,"Get up-to-date on the latest aspects of ventilator management in ARDS, including new and promising approaches."
  June 2019 ,European Heart Journal,Should NICE Guidelines for Evaluation of CAD be Universal?,This review presents the pros and cons of paradigm changing recommendations made by the National Institute of Health and Care Excellence for assessment and diagnosis of chest pain.
  June 2019 ,Rheumatology,Thromboembolic Risk in Systemic Lupus Erythematosus,Learn more about the risk factors for thrombosis in patients with SLE and the treatment options for these complications.
  June 2019 ,Current Opinion in Psychiatry,Prospects for Pharmacotherapies to Treat Alcohol Use Disorder,"This article summarizes recent studies on the use of pharmacological treatments for alcohol use disorder. What's currently in the armamentarium, and what novel therapies are under investigation?"
  June 2019 ,Stroke,Stroke in Patients With Peripheral Artery Disease,How common is stroke in patients with symptomatic peripheral artery disease? Should prevention strategies differ for this high-risk group?
  June 2019 ,Journal of Clinical Oncology,Platinums for First-Line Treatment of Advanced NSCLC?,Recent clinical trials have put immunotherapy front and center for initial treatment decisions in advanced lung cancer.
  June 2019 ,Nephrology Dialysis Transplantation,Cardiovascular Disease in Kidney Transplant Recipients,The evidence for cardiovascular risk stratification in kidney transplant recipients is lacking in this population. Might more field-specific research help bridge the gap?