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Clinical_Trials_Journals_Headlines.csv
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Date,Source,Headlines,Teaser
July 2002 ,Neurosurgical Focus,Outcome Measures for Clinical Trials in Neurotrauma,More than 40 years have passed since the first therapeutic trials were designed to test the ability of medications to improve outcome after severe TBI.
June 2002 ,Southern Medical Journal,Selected Ongoing Clinical Trials,The following trials are designed to help physicians treat osteoporosis.
July 2002 ,Medscape General Medicine,Medscape Psychopharmacology Today,Development process for drugs
May 2002 ,Southern Medical Journal,Selected Ongoing Clinical Trials,The following trials are designed to help physicians treat thyroid dysfunction.
June 2001 ,Abstracts in Hematology & OncologyTM,Urothelial Cancer: A Phase II Trial,A study evaluates efficacy and toxicity in previously untreated patients with advanced transitional cell carcinoma.
January 2002 ,Southern Medical Journal,Selected Ongoing Clinical Trials,The following clinical trials are designed to help physicians treat diabetes as well as their potential complications.
December 2001 ,Southern Medical Journal,The Female Patient: Selected Ongoing Clinical Trials,"The following trials are designed to help physicians keep up to date on the topics of cervical cancer, and more."
June 2001 ,Seminars in Neurology,Clinical Trials in ALS: An Overview,"Women's participation in clinical trials, particularly those involving drugs, has been said to be both overrepresented and underrepresented. Studies of participation are compared and contrasted to elucidate some reasons for this contradiction."
October 2001 ,Medscape General Medicine,Participation of Women in Clinical Trials of Drug Therapies,"Several new antifungal agents, including novel compounds in familiar classes and entirely new classes targeting previously untapped mechanisms, are in various stages of the drug development process."
August 2001 ,Pharmacotherapy,Investigational Antifungal Agents,"Although the market for lipid-lowering medications is dominated by statins, the rise in statins predated the recent clinical trials supporting their use."
June 2001 ,American Heart Journal,Randomized Clinical Trials and Recent Patterns in the Use of Statins,An excellent information Web site for clinical trials is now available.
June 2001 ,American Heart Journal,Randomized Clinical Trials and Recent Patterns,"Some of the revolutionary drugs expected from human genome research may reach the pharmacy shelf sooner than expected, according to Francis Collins, MD, director of the National Human Genome Research Institute at the National Institutes of Health."
March 2001 ,Cancer Control: Journal of the Moffitt Cancer Center,Resources on the Web - Searching for Information on Clinical Trials,Does the right of incarcerated prison and jail inmates to healthcare include access to clinical trials?
January 2001 ,Pharmacy Today,Genome Map Spurring Drug Development Ahead of Schedule,Review the Office for Human Research Protections and FDA guidelines relevant to the conduct of HIV/AIDS clinical trials in correctional facilities.
January 2001 ,The AIDS Reader®,HIV Clinical Trials in Correctional Settings: Right or Retrogression?,"Explore the advancements in clinical trial methodology, their utility in establishing treatment guidelines, and their impact on medical practice."
January 2001 ,The AIDS Reader®,IRB/FDA Requirements Relevant to HIV/AIDS Clinical Trials,"During the past few years, a number of abuses have been committed in clinical trials."
July 2007 ,International Journal of Clinical Practice,Recent Trials of Lipid Lowering,This narrative review summarises the key recent clinical trials of lipid lowering since 2004 and their implications for future patient care.
May 2007 ,The British Journal of Dermatology,Methyl Aminolaevulinate-photodynamic Therapy,The efficacy and low risk of side-effects afforded by this therapy have resulted in high patient preference in clinical trials.
May 2007 ,Nature Clinical Practice Oncology,A Remedy for Biomarker Addiction: Rational Anticancer Drug Development,The post-genomic era would seem to be an opportune time to rewrite the laws of cancer drug development. Where is the best place to start?
April 2007 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Metabolic Effects of Protease Inhibitor-Sparing ART Regimens Given for HIV,"Lipids were higher in efavirenz-containing 3- or 4-drug regimens, whereas body circumference measurements increased then returned to baseline by 192 weeks in this strategy trial."
April 2007 ,Nature Clinical Practice Oncology,How can we Improve Clinical Trials?,"Ideally, phase II oncology trials would quickly and efficiently identify genuine therapeutic advances. Strategies such as adding a 'real-world' cohort, amongst others, may facilitate improvement."
August 2006 ,Nature Clinical Practice Neurology,Confounders to Spinal Cord Injury Clinical Trials,"Learn about the status of translational research in spinal cord injury trials, focusing on issues about concurrent use of methylprednisolone, and other potential confounders and possible solutions."
February 2006 ,Alimentary Pharmacology & Therapeutics,7-Point Global Overall Symptom Scale for Dyspepsia,"At present, there is no consensus regarding the optimal method for measuring the severity of dyspepsia symptoms in clinical trials."
January 2006 ,Nature Clinical Practice Oncology,Phase III Clinical Trials on Anti-VEGF Therapy for Cancer,"Read the contrasting results, as well as mechanisms underlying normalization of tumor vasculature, and the need for biomarkers and imaging techniques to guide patient selection and protocol designs."
December 2004 ,Current Medical Research and Opinion,Measuring Symptom Response to Pharmacological Interventions,There is a clear need for a fully developed and validated tool for measuring the effects of therapeutic interventions on symptoms in COPD in clinical trials.
May 2004 ,Pharmacotherapy,Single-Dose Pharmacokinetics of Sodium Ferric Gluconate Complex,Sodium ferric gluconate complex in sucrose injection (SFGC) is an iron formulation marketed in the United States as Ferrlecit.
April 2004 ,Journal of Cardiovascular Electrophysiology,Drug-Induced Torsades de Pointes and Implications for Drug,"A review of the techniques and limitations of methods directed at drug-related phenomena, clinical trials, interpretation of ECGs, and evaluation of drug-related risks and benefits."
March 2004 ,Current Medical Research and Opinion,Eletriptan for the Acute Treatment of Migraine: Results of,"Eletriptan is a potent, selective 5-HT1B/1D agonist that has been studied in multiple double-blind, placebo-controlled clinical trials conducted on migraineurs in Europe, Australia, Canada and the US."
March 2004 ,Arthritis Research & Therapy,"Equipoise, Design Bias, and Randomized Controlled Trials","The concept of 'equipoise', the 'uncertainty principle', has been represented as a central ethical principle of human experimentation."
March 2004 ,Emerging Infectious Diseases,Clinical Trials and Novel Pathogens: Lessons From SARS,The recognition of SARS as a transmissible disease prompted international efforts to identify its cause and control its spread.
January 2004 ,Wounds,Protocols for Advanced Technology Clinical Trials,"Products, devices, and materials for the treatment of chronic and problematic wounds have, during the course of the last two decades, progressed from simple dressings acting as protective coverings to more complex drugs and biological devices."
October 2003 ,Dermatology Nursing,Dermatology Clinical Trials and Drug Development,Learn more about the drug development process and the role of the nurse.
October 2003 ,Medscape General Medicine,Understanding Clinical Trials in Context,It is important for clinicians to know about the realities of the world of clinical studies and how to read between the data.
August 2003 ,American Heart Journal,Most Hospitalized Older Persons Do Not Meet Enrollment Criteria,"A minority of hospitalized older persons with HF fit the profile of populations of clinical trials. There is an urgent need for research in HF for typical HF patients, including the very old."
June 2003 ,Medscape General Medicine,"Subgroup Analysis, Sex Differences, and Clinical Trials",This report presents some of the current debate regarding the design of clinical trials and the analysis of resulting data to accurately and efficiently detect sex differences.
February 2003 ,Neurosurgical Focus,Convection-Enhanced Delivery in Clinical Trials,"The poor prognosis associated with malignant primary brain tumors treated with conventional therapies such as surgery, radiotherapy, and chemotherapy has led investigators to develop new innovative therapies."
November 2008 ,Future Virology,Antiviral Drug Development: Progress and Pitfalls,The 21st International Conference on Antiviral Research witnessed a number of presentations on both novel and well-established viral targets. What are some of the new drug therapies in development?
November 2008 ,The Medscape Journal of Medicine,The Myth of Equipoise in Phase 1 Clinical Trials,"The continued use of the ethically and scientifically invalid concept of ""equipoise"" in phase 1 clinical research trials undermines the ethics of research with human subjects."
July 2008 ,Future Neurology,fMRI: Use In Early Alzheimer's Disease And In Clinical Trials,"Functional MRI (fMRI) provides a means to investigate alterations in brain function related to the earliest symptoms of AD, possibly before development of significant irreversible structural damage."
July 2008 ,Future Virology,Antivirals: Current State of the Art,Antiviral drug development is now progressing at the pace antibiotics were 30 years ago. Learn more about current develops here.
August 2008 ,Expert Review of Respiratory Medicine,Antituberculous Drug Development and Novel Drug Targets,"A review of the development status of new anti-tuberculous drugs is presented, such as nitroimidazoles, diarylquinolines, diarylquinolines and oxazolidinones."
August 2008 ,Future Lipidology,Clinical Trials and Surrogate End Points: Lessons From the ENHANCE Trial,ENHANCE trial design and methods are explored in the context of related lipid lowering drug trials.
June 2008 ,Europace,Anti-arrhythmic Drug Therapy for Atrial Fibrillation,Anti-arrhythmic drug therapy for atrial fibrillation has expanded. Explore the current slate of conventional and non-conventional agents in this thought provoking review.
June 2008 ,Future Oncology,Status of Therapy for Chronic Myeloid Leukemia: Review of Drug Development,"Chronic myeloid leukemia treatment is relatively effective, but some problems have begun to emerge. Learn what the problems are and how newer generations of CML drug therapies may solve them."
March 2008 ,Personalized Medicine,The Impact of US FDA Postapproval Tracking on Clinical Pharmacology,"Pending legislation could improve cooperation between drug sponsors, the federal government, and clinicians to ensure that genetic data are considered during crucial stages of drug development."
February 2008 ,European Heart Journal,The Need for a Consensus Definition,This paper examines issues related to defining heart failure events in cardiovascular clinical trials and presents a definition to formally address this issue.
January 2008 ,IRB: Ethics & Human Research,"Patient Knowledge, Perception & Likelihood of Trial Partcipation",The impact of clinical trials is reviewed. What is the likelihood that a person will participate in a clinical trial; what are their perceptions regarding clinical research?
November 2007 ,PLoS Medicine,Clinical Trials and Medical Care: Defining the Therapeutic Misconception,Therapeutic misconception describes a phenomenon when research participants do not appreciate that research and treatment are different but can a consistent definition be proposed and operationalized?
September 2007 ,CHEST,Analyzing the Short-term Effect of Placebo Therapy in PAH,"Placebo therapy for pulmonary arterial hypertension (PAH) is common, but debated, in PAH treatment trials. What are the functional, hemodynamic, and clinical effects of placebo in adult PAH patients?"
September 2007 ,Journal of the American Board of Family Medicine,Understanding the Quality Chasm for Hypertension Control in Diabetes,How can you translate innovations from clinical trials to routine practice to improve hypertension control in diabetes?
August 2007 ,Nature Clinical Practice Oncology,Molecular Imaging can Accelerate Anti-Angiogenic Drug Development and Test,Angiogenesis is regulated by numerous molecular pathways that could serve as targets for molecular imaging. What is the role of molecular imaging in anti-angiogenic drug development?
May 2007 ,British Journal of Cardiology,Clinical Trials Versus the Real World:The Example of Cardiac Rehabilitation,Is cardiac rehabilitation as currently practiced in the UK as effective as clinical trials may suggest?
August 2007 ,Rheumatology,"Vitamins A, C, E and selenium in the treatment of arthritis","A systematic review of randomized clinical trials for the effectiveness of the antioxidant vitamins A, C, E or selenium or their combination in the treatment of arthritis."
July 2007 ,AIDS,Should We Now Adopt the HIV-RNA < 50 Copy Endpoint for Clinical Trials?,These authors posit that HIV-RNA suppression < 50 copies/ml should be the standard efficacy endpoint in trials of naive and experienced patients as this endpoint has stronger durability over time.
August 2007 ,IRB: Ethics & Human Research,Who Should Go First in Trials with Scarce Agents? The Views,"Access to drugs not approved by the FDA remains controversial. Even greater access is being called for, but the competing rights of the individual versus the state continue to complicate this issue."
February 2007 ,Psychopharmacology Bulletin,Simple Options for Improving Signal Detection in Antidepressant Clinical,Effective antidepressants are not distinguished efficiently from placebos using signal detection. Might 3 easy-to-implement methodologies benefit signal detection and clinical trial design?
November 2009 ,IRB: Ethics & Human Research,Competing Commitments in Clinical Trials,The goals of clinical research and clinical care are often at odds. This survey highlights the potential for clinical commitments of providers to undercut the requirements of research.
November 2009 ,Personalized Medicine,Will Personalized Medicine Help in 'Transforming' the Business of Healthcare?,"In order for personalized medicine to have its desired impact, innovative business models will be required to address competing financial interests."
November 2009 ,Expert Review of Clinical Pharmacology,Novel Antibiotics for the Treatment of Staphylococcus aureus,"A leading cause of nosocomial infections, MRSA is a serious issue for all institutions. What are the newest drug therapies for this often fatal pathogen?"
November 2009 ,European Journal of Heart Failure,Clinical Trials Update from the ESC Heart Failure Meeting 2009,"Here is information and a commentary on five recent trials with findings relevant to the pathophysiology, prevention, and treatment of heart failure."
November 2009 ,International Journal of Clinical Rheumatology,What's New in Clinical Trials in Lupus?,"Recent trials have explored the efficacy of old, widely used therapies, as well as newer agents, to prevent lupus flares and for maintenance therapy."
November 2009 ,Journal of the National Cancer Institute,Prospective Cost-effectiveness Analysis of Cetuximab in Metastatic Colorectal Cancer,Prospectively collected resource utilization and health utility data for patients with CRC in the CO.17 study who received best supportive care +/- cetuximab were assessed for cost effectiveness.
October 2009 ,Clinical Lung Cancer, Cooperative Group Research Endeavors in Small-Cell Lung Cancer ,"This article discusses the scientific vision of various cooperative groups regarding small-cell lung cancer research, as presented at the 2008 International Lung Cancer Congress (ILCC)."
October 2009 ,Nanomedicine,Neurodegenerative Disorders and Nanoformulated Drug Development,"Nanotechnology-driven therapies hold the promise of altering the clinical course and outcome of Alzheimer's disease and other common, debilitating and hard-to-treat neurodegenerative disorders. "
February 2009 ,Malaria Journal,Clinical Trials to Estimate the Efficacy of Preventive Interventions Against Malaria in Paediatric Populations,"How can trial design be improved and standardized to enable comparative evaluation of malaria control measures in pediatric populations, specifically with respect to the design of malaria vaccine trials?"
August 2009 ,Annals of Surgery,Use of Emerging Oral Anticoagulants in Clinical Practice,This is an important review of clinical studies of the oral anticoagulants in preventing postoperative venous thromboembolism.
February 2009 ,Nature Clinical Practice Gastroenterology & Hepatology,How to Critically Appraise an Article,"This review article presents a 10-step guide to the critical appraisal of research literature to assist clinicians in identifying relevant, high-quality studies to guide their clinical practice."
January 2009 ,HIV Clinical Trials,Preparticipation Information on Posttrial Services of HIV Clinical Trials,Whether patients participate in clinical trials may hinge on whether they’ll receive medications or medical care after the trial ends. How often are retroviral drug trials providing this information?
June 2009 ,Expert Review of Hematology,Optimal Treatment for Relapsing Patients With Hodgkin Lymphoma,Relapsed/refractory Hodgkin lymphoma (HL) is still a therapeutic challenge. What are some novel investigational treatments for relapsing patients?
June 2009 ,Faculty of 1000,"A Call for More Transparency of Registered Clinical Trials on Endometriosis. Ranked ""Exceptional"" by F1000",The need for exposure of important research in endometriosisto the medical and public eyes is long overdue.
May 2009 ,IRB: Ethics & Human Research,An Intervention to Improve Cancer Patients' Understanding of Early-Phase Clinical Trials,Could a computer-based informed consent intervention help clarify patients' expectations about a trial's purpose and benefit?
November 2008 ,Neurosurgical Focus,Protection and Repair of the Injured Spinal Cord,This article reviews current clinical trials that could revolutionize management of acute spinal injury.
January 2009 ,IRB: Ethics & Human Research,Including Persons With Alzheimer Disease in Research on Comorbid Conditions,What is the appropriate balance between protecting Alzheimer patients from the potential risks of research while allowing them to participate in trials that could lead to medical benefit?
December 2008 ,Kidney International,DRIVE it Home: The Case for Prospective Economic Data Collection in RCTs,The DRIVE and DRIVE-II trials evaluated the efficacy of IV ferric gluconate in anemic dialysis patients but how can we extrapolate these data to change public policy and reimbursement practices?
November 2008 ,AIDS,HIV Clinical Trial Design for Antiretroviral Development,How can proper clinical trial design affect antiretroviral development?
November 2008 ,Expert Review of Clinical Immunology,Inhaled Corticosteroids as Rescue Medication in Acute Severe Asthma,The clinical evidence regarding the use of inhaled corticosteroids in acute asthma patients are reviewed.
January 2010 ,BMC Pharmacology,Antinociceptive Effects of Extracts from Pterodon pubescens ,A Brazilian medicinal plant has pain-relieving properties.
February 2010 ,Expert Review of Hematology,Autologous Hematopoietic Stem Cell Transplantation in Autoimmune Diseases,"This article discusses the growing experience in the use of HSCT in various autoimmune diseases, including multiple sclerosis, Crohn’s disease, and systemic sclerosis."
December 2009 ,BMC Clinical Pharmacology,Bioavailability of Different Ibuprofen Preparations,A phase I trial compares the absorption rates of different ibuprofen formulations.
February 2010 ,AIDS Clinical Care,HIV Outcomes in the Clinic: Now as Good as in Clinical Trials,Example Teaser
December 2009 ,Expert Review of Hematology,Acute Myeloid Leukemia Stem Cells: Seek and Destroy,This article reviews bench and translational research in leukemic stem cells and discusses how the data should be used to change the direction of developmental therapeutics and clinical trials in AML.
February 2010 ,Journal Watch,HIV Outcomes in the Clinic: Now as Good as in Clinical Trials,"HIV treatment outcomes have significantly improved over the years, but by just how much? "
February 2010 ,Arthritis Research & Therapy,Molecular Therapies for Systemic Lupus Erythematosus: Clinical Trials and Future Prospects,Exploring new pharmacological options and therapeutic avenues for lupus: a focus on non-antibody molecular strategies.
January 2010 ,IRB: Ethics & Human Research,Bipolar Mania and Capacity to Consent: Recommendations for Investigators,What is the decisional capacity of individuals with bipolar mania and other mental disorders?
January 2010 ,PLoS Medicine,Are Patents Impeding Medical Care and Innovation?,"Is the current patent system actually stimulating biomedical research and innovation, or is it stifling it by raising costs and restricting access?"
January 2010 ,American Journal of Health-System Pharmacy,Pharmacokinetics of Extended-Release Epidural Morphine Sulfate,How does extended-release epidural morphine compare with standard epidural morphine?
January 2010 ,BMC Clinical Pharmacology,In Vivo Administration of BL-3050: Highly Stable Engineered PONI-HDL Complexes,A recombinant HDL-associated enzyme and its HDL complex may have a role in treating organophosphate poisoning and atherosclerosis.
January 2010 ,BMC Pharmacology,Evaluation of Molecular Descriptors for Antitumor Drugs,Understanding chemical properties of these antineoplastic agents may lead to new drug designs.
December 2009 ,The Nation's Health,New Books Showcase Ethical Issues in Public Health Practice,Ethical issues in public health research and practice now occupy a prominent place in the public health landscape. Two new books provide some guidance for students and professionals.
December 2009 ,Expert Review of Gastroenterology and Hepatology,Therapeutic Vaccination and Novel Strategies to Treat Chronic HBV Infection,This study focuses on therapeutic vaccination in HBV and discusses potential ways to effect efficient restoration of virus specific immunity in patients with chronic HBV.
December 2009 ,BMC Clinical Pharmacology,Interactions Between Transdermal Selegiline and Cocaine Infusion,"For potential treatment of cocaine dependence, researchers investigate whether an interaction exists between selegiline and cocaine."
December 2009 ,The Hastings Center Report,A Tool to Strengthen The Doctor-Patient Relationship,"Comparative effectiveness can ""serve to protect us from our worst impulses and to nurture our very best ones,"" according to the author of this article. "
December 2009 ,IRB: Ethics & Human Research,Voluntariness of Consent to Research,"Practice-based research networks are burgeoning, and offer an ideal venue for the study of common medical problems, but further maturation is needed for them to fulfill their promise."
December 2009 ,Journal of the American Board of Family Medicine,Increasing the Role of Practice Networks in Medical Research,"Volunteering for research studies is laudable--and for heart failure patients, it may also be an independent prognostic variable."
June 2010 ,BMC Clinical Pharmacology,Traumeel S for Pain Relief Following Hallux Valgus Surgery,Traumeel S for Pain Relief Following Hallux Valgus Surgery: A Randomized Controlled Trial
May 2010 ,U.S. Pharmacist,LASIK Refractive Eye Surgery in the 21st Century,"This surgery is a fast, safe, and cost-effective alternative to glasses and contact lenses."
May 2010 ,Expert Review of Clinical Pharmacology,Keeping the Rhythm: hERG and Beyond in Cardiovascular Safety Pharmacology,What is the relationship between the hERG ion channel and torsades de pointes?
May 2010 ,Rheumatology,Lupus Clinical Trials: What Have We Learned So Far?,What treatments are on the horizon for lupus? This review looks at some potential options.
May 2010 ,Expert Review of Clinical Pharmacology,K+ Channels in the Heart: New Insights and Therapeutic Implications,Will drugs targeting atrial K+ channels have decreased risk of proarrhythmia?
May 2010 ,The Annals of Pharmacotherapy,Adverse Drug Events in Adult Patients Leading to ED Visits,"How commonly are adverse drug events responsible for ED visits, and which drugs are most often involved?"
May 2010 ,BMC Clinical Pharmacology,EVITA: A Tool for the Early Evaluation of Pharmaceutical Innovations With Regard to Therapeutic Advantage,This screening tool serves to evaluate the additional therapeutic value of new drugs compared to similar drugs.
May 2010 ,American Heart Journal,Bridging the Gap Between Clinical Trials of Antiplatelet Therapies and Applications Among Elderly Patients,The paradox of both clotting and bleeding easily keeps elderly patients out of trials studying acute coronary syndromes and peri-PCI treatments. How can extrapolate data for this growing population?
March 2010 ,Malaria Journal,Engaging Diverse Communities Participating in Clinical Trials: Case Examples From Across Africa,Getting local communities in Africa involved in malaria research can pay big dividends.
April 2010 ,BMC Pharmacology,BIAdb: A Curated Database of Benzylisoquinoline,A new database may assist those researching drug discoveries based on natural products.
May 2010 ,Current Opinion in Pulmonary Medicine,New Drugs and New Regimens for the Treatment of TB: Review of Drug ,"The authors review the problems related to drug-resistant TB, describe recent advances in the development of new drugs, and discuss implications for control programs."
March 2010 ,BMC Pharmacology,Targeting Ligand-Gated Ion Channels in Neurology and Psychiatry,"Could ""magic shotguns,"" drugs capable of interacting with multiple targets, be alternatives to ""magic bullets,"" drugs with high-specificity?"
April 2010 ,American Journal of Health-System Pharmacy,Facilitating Evidence-Based Prescribing for Unlabeled Use of Medications,Pharmacists should be educators about off-label use of medication.
April 2010 ,Journal Watch,A Critical Look at Flu Vaccine Studies,Influenza vaccine efficacy studies can yield misleading data if conducted at the wrong time.
March 2010 ,Journal of Pediatric Psychology,Research and Practice: The Role of the Journal of Pediatric Psychology,This editorial outlines The Journal of Pediatric Psychology's current and future directions in publishing clinically relevant work.
April 2010 ,American Journal of Health-System Pharmacy,Significant Publications on Infectious Diseases Pharmacotherapy in 2008,Read summaries of important articles on infectious disease therapy.
March 2010 ,Expert Review of Proteomics,Role for Protein-Protein Interaction Databases in Human Genetics,"Since protein databases are now widely available, how does this impact research on protein-protein interactions?"
January 2010 ,BMC Nephrology,Follow-up of Phase I Trial of Adalimumab and Rosiglitazone in FSGS,Antifibrotic therapy for a defined period of time may be a viable strategy to preserve kidney function in patients with resistant focal segmental glomerulosclerosis.
March 2010 ,Annals of Oncology,Randomized Placebo-Controlled Study of Tamoxifen After Adjuvant Chemo,Premenopausal women with early breast cancer could have improved 5-year survival when Tamoxifen is used after adjuvant chemotherapy.
February 2010 ,BMC Clinical Pharmacology,A Systematic Review of Analgesics After Traumatic or Orthopaedic Surgery,A review evaluates the quality of trials on analgesic use post orthopedic or traumatic surgery.
August 2010 ,BMC Pharmacology,Quantitative In Vitro and In Vivo Pharmacological Profile of CE-178253,Will this cannabinoid receptor antagonist be a possible treatment for obesity?
September 2010 ,Europace,Implantable Electrical Devices for Prevention of SCD,A web-based registry was instituted to collect data for all ICDs implanted in a region with around 4.3 million inhabitants. Do registry results show adherence to guidelines?
September 2010 ,Journal of Pediatric Psychology,A Call for Replications of Research in Pediatric Psychology,The author addresses the need for more frequent research replications in the field of pediatric psychology.
August 2010 ,American Journal of Health-System Pharmacy,Evaluating Equivalence and Noninferiority Trials,Do you know how to interpret negative results from a superiority trial
July 2010 ,AccessMedicine from McGraw-Hill,Pediatric Pharmacotherapy Part 1: The History of Pediatric Drug Therapy,"For far too long, ethical and practical problems minimized the use of children in drug studies; therefore, much of pediatric pharmacotherapy even today is based more on error than trial ."
July 2010 ,Annals of Oncology,Absolute Benefits of Medical Therapies for Breast and CRC,RCTs may be arriving at a point-of-diminishing-return for breast and colorectal cancer treatment initiatives.
August 2010 ,Future Microbiology,TMC207: The First Compound of a New Class of Potent Anti-Tuberculosis Drugs,"TMC207, a new compound with a novel mechanism of action, may be a breakthrough in the fight against drug-sensitive and drug-resistant TB."
July 2010 ,BMC Pharmacology,Prediction of Cytochrome P450 Isoform Responsible for Metabolizing a Drug,Is a drug metabolized by CYP? New research is answering this question quickly and accurately.
August 2010 ,Journal of Cardiovascular Electrophysiology,The DIONYSOS Study,A comparison of the benefit/risk ratio of dronedarone and amiodarone is made for patients with atrial fibrillation.
August 2010 ,American Heart Journal,Study Design and Rationale of a Comparison of Prasugrel and Clopidogrel in Medically Managed Patients ,"The largest randomized clinical trial to date, focusing exclusively on medically managed NSTE ACS patients, will provide important information regarding the optimal approach to oral antiplatelet therapy for this high-risk population."
May 2010 ,IRB: Ethics & Human Research,The Evolution of Consent Forms for Research: A Quarter Century of Changes,How has the consent form evolved over the past few decades? This new study explores the changes.
July 2010 ,Journal of the American Board of Family Medicine,What Do We Get From Participating in Practice-based Research Networks?,The author makes a case for practice-based research as a good fit in a health care environment with new interest in translational research at one end and health care reform at the other.
May 2010 ,Journal of Hospital Medicine,Comparative Effectiveness Research: Implications for Hospital Medicine,Learn how comparative effectiveness research is different from standard research that hospitalists use to inform their clinical decision-making.
June 2010 ,American Heart Journal,Unexplained International Differences After AMI and Fibrinolytic Therapy,Disparity between nations may be part of the learning curve for large-scale international trials.
June 2010 ,Nanomedicine,Nanomedicinal Strategies to Treat Multidrug-Resistant Tumors,Are nano-based drug delivery systems the answer to multi-drug resistance in solid tumor chemotherapy?
June 2010 ,Critical Care Medicine,Plasma Interleukin-8 is not an Effective Risk Stratification Tool for Adults ,"Plasma biomarkers provide a potentially useful approach to risk stratification of patients before enrollment in clinical trials, but may not be ready for prime time use across populations."
April 2010 ,Expert Review of Cardiovascular Therapy,Aptamers: the Emerging Class of Future Anticoagulation for Vascular Disease,"Aptamers are known for their high potency, low safety concerns, and an excellent toxicology profile. Learn more about this up and coming class of anticoagulants in this review."
November 2010 ,Oncology Nursing Forum,Initiative to Standardize a Clinical Trial Educational Program ,Improving the process of assisting oncology patients in making informed decisions about clinical trials pays dividends for all.
October 2010 ,The Pediatric Infectious Disease Journal,Immunogenicity and Safety of Trivalent Two Inactivated Influenza Vaccines,Is the inactivated influenza vaccine Fluarix--currently approved only for children older than 3 years--as safe and effective as Fluzone in children under that age?
October 2010 ,American Journal of Pharmaceutical Education,Presenting and Evaluating Qualitative Research,"Qualitative data includes diaries, photographs, and questionnaires."
October 2010 ,Nanomedicine,Polymer-Drug Conjugates For Novel Molecular Targets,"Polymer-drug conjugates are now used in cancer therapy, but potential future applications are far-ranging, including diabetes, hypertension, infections, digestive tract diseases and inflammation."
October 2010 ,Health and Quality of Life Outcomes,Patient Reported Outcomes: Looking Beyond the Label Claim,Should patient reported outcomes be viewed as an essential complement to traditional clinical evidence in pharmaceutical product development?
October 2010 ,European Heart Journal,Shock in AMI: The Cape Horn for Trials?,"This review outlines the underlying causes, pathophysiology, and treatment of cardiogenic shock in AMI."
October 2010 ,Journal of the National Cancer Institute,"Large Trials, Small Gains: Is Change on the Way? ",Proposed fixes for important aspects of the cancer research infrastructure may help to fill in the cracks of a stressed foundation.
October 2010 ,BMC Pharmacology,Hematopoietic Stem Cells Exhibit a Specific ABC Transporter Gene Profile ,Is stem cell function dependent on specific ABC transporter gene expression?
October 2010 ,Nanomedicine,Surface-Modified PLGA-Based Nanoparticles Can Deliver Virus-Like Particles,"A new nanocarrier, specifically engineered for the association and transmucosal delivery of a virus-like particle, is a promising novel approach for vaccine delivery."
October 2010 ,Pediatric Pharmacotherapy,Adverse Drug Events in Children: Recent Cases from the Medical Literature,This article summarizes several important pediatric adverse drug event case reports and clinical trials published within the past year.
October 2010 ,Future Neurology,Latrepirdine for Alzheimer's Disease: Trials and Tribulations,"Early studies showed potential for latrepirdine in treatment of Alzheimer's disease, but results of subsequent trials have been discouraging. Why did it fail? "
October 2010 ,Pharmacotherapy,Evaluation of Renal Drug Dosing,Are clinicians routinely using eGFR or MDRD?
October 2010 ,Skin Therapy Letter,Nanodermatology: A Bright Glimpse Just Beyond the Horizon - Part I,"An overview of exciting new developments in nanotechnology as it relates to skin care, not only for cosmetics but for diagnostics and therapeutic agents as well."
October 2010 ,Faculty of 1000,The Reality of Drug Shortages--The Case of The Injectable Agent Propofol,The development of methods to counteract drug shortages is crucial before patient care is adversely affected
October 2010 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,The Association Between Money and Opinion in Academic Emergency Medicine,What influence does grant money have on academic opinion leaders?
October 2010 ,Arthritis Research & Therapy,Efficacy Assessed in Follow-ups of Clinical Trials: Methodological Conundrum,Are certain patients with rheumatoid arthritis more likely to get osteoporosis than others?
September 2010 ,Expert Review of Clinical Immunology,RAPID and FAST4WARD Trials: Certolizumab Pegol for Rheumatoid Arthritis,Rheumatoid arthritis treatment options are rapidly expanding and this article will bring you up-to-speed.
September 2010 ,Journal Watch,BRAF and Melanoma: Taking It Personally,"In this exciting and widely publicized study, more than 80% of melanoma patients with the BRAF mutation responded to treatment with the novel agent PLX4032."
September 2010 ,Arthritis Research & Therapy,Efficacy Assessed in Follow-ups of Clinical Trials: Methodological Conundrum,What types of problems can arise when comparing results of various randomized clinical trials?
September 2010 ,Expert Review of Neurotherapeutics,Vitamin D and Multiple Sclerosis: What Are the Guidelines for a Reliable Clinical Trial?,"Some studies have shown a causal relationship between low serum vitamin D levels and disease activity in MS, but were their methods rigorous enough?"
January 2011 ,Personalized Medicine,Biobanking in Pediatrics,A biobank is a collection of tissue and health information used for research.
January 2011 ,Personalized Medicine,Genetics of Osteoporosis: Perspectives for Personalized Medicine,Can pharmacogenomics help mitigate the risk of osteoporosis?
November 2010 ,Personalized Medicine,Pharmacogenomics and Adverse Drug Reactions,Can we identify patients with predispositions for ADRs?
January 2011 ,Expert Review of Clinical Pharmacology,Hydrogen Sulfide in the Endocrine and Reproductive Systems,Some endocrine disorders are associated with changes in hydrogen sulfide biosynthesis.
December 2010 ,International Journal of Clinical Practice,Update on Treatments for Premature Ejaculation,Review current and investigational strategies for the therapeutic management of premature ejaculation. What's the best approach?
December 2010 ,Critical Care,H-2 Antagonists vs Sucralfate in Ventilated Patients,The more efficacious treatment for stress ulcer prevention in ventilated patients may also have an impact on VAP.
December 2010 ,Nanomedicine,Biodistribution of Polymersomes Into Oral Squamous Cell Carcinoma Cells,"This study looks at the potential of polymersomes to deliver chemotherapeutic agents or gene therapy intracellularly in oral squamous cell carcinoma, a common cancer with a poor prognosis."
November 2010 ,BMC Family Practice,Pregabalin Safety and Efficacy in Older Patients With Neuropathic Pain,"Pregabalin has been shown to be safe and effective for management of chronic neuropathic pain younger patients, but what about in those over 65 years of age?"
October 2010 ,Annals of Oncology,Optimal Treatment for Relapsing Ovarian Cancer,The most promising strategies being used in RCTs are featured in this review of relapsed ovarian cancer treatment.
November 2010 ,Cardiovascular Ultrasound,Standardized Ultrasound Evaluation of Carotid Stenosis for Clinical Trials,"Many clinical trials of carotid artery repair are underway, but how should results be evaluated? UWURC proposes a uniform examination protocol using duplex Doppler velocimetry."
November 2010 ,Skin Therapy Letter,Nanodermatology: A Glimpse of Caution Just Beyond the Horizon - Part II,"While there are many exciting new uses of nanotechnology in dermatology, there are many toxicity concerns that must addressed before nanomedicine can reach its full potential."
November 2010 ,Journal of the National Cancer Institute,Improved Endpoints for Cancer Immunotherapy Trials,Immunotherapeutic mechanisms of action call for refined treatment endpoints in cancer therapy.
November 2010 ,Annals of Clinical Microbiology and Antimicrobials,Effects of Antibacterial Mineral Leachates on E. Coli and MRSA,Certain mineral mixtures and their aqueous leachates have demonstrated in vitro antibacterial activity. What is their mechanism of action?
November 2010 ,Nanomedicine,Antiangiogenic Nanotherapy With Methotrexate for Inflammatory Arthritis,"In this animal study, fumagillin nanoparticles showed promise as a treatment of rheumatoid arthritis when combined with a conventional antirheumatic drug."
November 2010 ,Neurosurgical Focus,Acromegaly: Review of Current Medical Therapy and New Drugs on the Horizon,"New somatostatin analogs, novel chimeric ligands, and extended delivery implants--all currently in clinical trials--bring new hope for sufferers of acromegaly."
November 2010 ,American Heart Journal,Are Changes in Carotid Intima-Media Related to Risk of Nonfatal MI? ,Carotid intima-media thickness may not be the best surrogate endpoint in RCTs. Learn why.
November 2010 ,Journal Watch,Mammography Revisited: Does Screening Lower Breast Cancer-Related Mortality?,"According to a Norwegian study, screening mammography may not lower mortality by as much as previously thought. "
March 2011 ,American Heart Journal,Review of Event Rates in Diabetes Clinical Trials,Just how influential are these two variables on cardiovascular event rates in diabetes trials?
March 2011 ,Journal of Participatory Medicine,Citizen Science Genomics for Preventive Medicine Research,"This paper proposes a research model for conducting citizen science genomics, integrating personal genomic data with physical biomarker data to be applied in large-scale preventive medicine studies."
March 2011 ,Journal of the National Cancer Institute,QoL Measurement in RCTs in Breast Cancer ,When do measures of self-reported symptoms have the most utility in breast cancer research?
February 2011 ,BMC Clinical Pharmacology,Pharmacokinetics of Phenoxodiol,This isoflavone is being investigated in prostate and breast cancer.
March 2011 ,Nanomedicine,Efficient Gene Delivery by EGF-Lipoplexes In Vitro and In Vivo,Could EGF-receptor targeted lipoplexes serve as alternatives to viral nanovectors for gene therapy?
February 2011 ,Nature Reviews Neurology,Paving the Way for Alzheimer Disease Drug Development,Advances in Alzheimer disease research during 2010 have identified promising novel diagnostic tools and therapeutic targets. Read about four of the most exciting studies in this review.
March 2011 ,Cancer Nursing,Improving Hospice Outcomes Through Systematic Assessment,The efficacy of systematic feedback from standardized assessment tools for hospice patient-caregiver dyads is evaluated.
February 2011 ,Journal of the National Cancer Institute,Randomized Trial of Induction Chemotherapy in Metastatic CRC,What does this updated analysis of a first-line treatment trial for patients with metastatic CRC tell us about induction?
February 2011 ,Nanomedicine,Self-Nanoemulsifying Drug Delivery Systems,Learn about self-nanoemulsifying drug delivery systems--one of the many ways by which nanotechnology can improve delivery and therapeutic efficacy of drugs.
February 2011 ,Future Microbiology,Antimalarial Drugs: Modes of Action snd Mechanisms of Resistance,"An examination into the drug resistance mechanisms at work in P. falciparum, the malaria parasite species which accounts for 90% of deaths worldwide."
March 2011 ,Current Opinion in Psychiatry,Placebo Response In Clinical Trials With Schizophrenia Patients,Excessive placebo response is an important factor in the failure rate of clinical trials for schizophrenia drugs. What are the potential causes and what steps can be taken to minimize this effect?
February 2011 ,Journal of the National Cancer Institute,"When Are ""Positive"" Oncology Trials Truly Positive? ",The importance of clinical significance is discussed in comparison to statistical significance in clinical trials for cancer treatment.
February 2011 ,Headache,Clinical Efficacy of Telcagepant in Migraine,The calcitonin gene-related peptide antagonist telcagepant may be a breakthrough in migraine therapy because of its novel approach--but is it as effective as more traditional drugs?
January 2011 ,Nanomedicine,Engineering Nanomedicines for Improved Melanoma Therapy,"The search for better outcomes in malignant melanoma has led to new immunotherapies and chemotherapeutic agents, but more effective delivery methods are urgently needed. Nanotechnology provides hope."
January 2011 ,Journal of the National Cancer Institute,Comparative Effectiveness of Prostate Cancer Treatments,Authors evaluated methods for addressing confounding in treatment and survival of patients with early-stage prostate cancer in observational data.
January 2011 ,IRB: Ethics & Human Research,The Globalization of Clinical Trials: The Promise and Perils ,What happens when clinical trials get outsourced to foreign countries? This new book explores the issues.
January 2011 ,Journal of the National Cancer Institute,Assessment of Clinical Validity of a Breast Cancer Risk Model ,A synergistic approach to risk profiling may provide the most useful information - from both clinical and genetic variables.
January 2011 ,Current Opinion in Allergy and Clinical Immunology,Common Variable Immunodeficiency ,"This review highlights the most important publications of the past year, with an emphasis on novel findings in genetics and the immunophenotype of CVID."
January 2011 ,Expert Review of Clinical Pharmacology,Therapeutic Potential of Hydrogen Sulfide-Releasing Hybrids,These gasotransmitter hybrids have promise for treating inflammation.
April 2011 ,Immunotherapy,Cellular Immunotherapy for High-Grade Glioma,"The outcome for patients with glioblastoma multiforme remains poor, but new cellular strategies may brighten the outlook."
April 2011 ,Headache,"MAP0004, Orally Inhaled DHE for Acute Treatment of Migraine","This RCT looks at the efficacy of MAP0004, an orally inhaled formulation of dihydroergotamine for the treatment of acute migraine. How did it fare against placebo?"
April 2011 ,Journal of the National Cancer Institute,Proposed New Clinical Trial System at NCI Gets Mixed Reviews,Oncology community leaders got a look at the National Cancer Institute's proposal for renovating its clinical trial system and found fundamental changes that will undoubtedly impact clinical research and practice.
May 2011 ,Current Opinion in Psychiatry,"Ethical, Legal and Social Issues in Alcohol and Drug Research","Research projects involving alcohol and drugs present many ethical, legal and social aspects that need to be taken into consideration, especially in relation to the informed consent process."
April 2011 ,Journal of the American College of Cardiology,Predictors of New-Onset Diabetes in Patients Treated With Atorvastatin,"High dose statins may be associated with the onset of diabetes, at least for some. Who is most at risk and why?"
April 2011 ,Expert Review of Anticancer Therapy,Targeted Therapy for SCC of the Head and Neck,"New treatments, especially targeted agents and novel combined regimens, are being evaluated in ongoing clinical trials for SCCHN."
April 2011 ,IRB: Ethics & Human Research,(Mis)Understanding Exploitation,This article explores the issue of exploitation in the area of biomedical research.
April 2011 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Prophylactic Antibiotics for Dog Bites with Refined Cost Model,"Does it make economic sense to treat all dog bite patients with antibiotics, even if the risk of infection is unknown?"
April 2011 ,Cancer Control: Journal of the Moffitt Cancer Center,Direction of Future Clinical Trials for Ovarian Cancer,"Over the last several decades, clinical trials have defined the therapeutic approach for ovarian cancer. Future trials promise new directions."
April 2011 ,Personalized Medicine,The N-of-1 Clinical Trial,Single subject studies may help advance personalized medicine.
March 2011 ,Nanomedicine,Graphene in Biomedicine: Opportunities and Challenges,"Graphene, an allotrope of carbon, has exciting potential for various biomedical applications, including drug delivery, cancer therapies and biosensing. "
March 2011 ,Journal of the American Board of Family Medicine,Postpartum Diagnostic Depression Interview is Problematic,Using a formal DSM-IV-based interview to identify depression in postpartum mothers may have serious flaws that could lead to underdiagnosis
March 2011 ,Journal Watch,Cell-Culture-Derived Influenza Vaccine: Safe and Efficacious,New approaches to influenza vaccine production are needed in order to meet high demand. Is a cell-culture-derived vaccine as safe and effective as egg-based?
March 2011 ,Expert Review of Clinical Pharmacology,Regulation of Appetite to Treat Obesity,How do medications alter the desire to eat?
March 2011 ,HIV Medicine,HIV/AIDS Patients and Clinical Trials in the HAART Era,Who is most likely to sign up to participate in an HIV/AIDS clinical trial? This study looks at the data.
March 2011 ,Expert Review of Clinical Pharmacology,Corticosteroids in Brain Cancer Patients,How does dexamethasone reduce peritumoral edema?
March 2011 ,Nature Reviews Clinical Oncology,Methodological Challenges for Personalized Cancer Therapies,"Many clinical trials of targeted therapies have produced disappointing results, but biomarker identification and other strategies outlined in this article should help to improve outcomes."
March 2011 ,Expert Review of Neurotherapeutics,A New Treatment Algorithm in Multiple Sclerosis,How do the newly approved and emerging oral therapies for multiple sclerosis fit into existing treatment strategies? And how might a new treatment algorithm evolve in the near future?
March 2011 ,Nanomedicine,Nanocarriers for Pulmonary Administration of Peptides and Proteins,"Peptides and proteins are an important class of therapeutic agents, but their efficient and safe administration has proven challenging. Could inhaled delivery via nanocarriers be the answer?"
August 2011 ,Annals of Oncology,Pancreatic Cancer Treatment and Research,Learn about the most important strides that have been made in improving outcomes with pancreatic cancer therapy.
July 2011 ,U.S. Pharmacist,The Pharmacist's Role in Preventing Antibiotic Resistance,What is antibiotic stewardship?
August 2011 ,International Journal of Clinical Rheumatology,Promising Developments in Osteoporosis Treatment,Promising new treatments for osteoporosis are under study.
July 2011 ,Future Microbiology,Antimicrobials for Bacterial Bioterrorism Agents,The efficacy of current antimicrobials against highly virulent pathogens that may be used in bioterrorism is limited. What current options and new strategies in drug development show promise?
July 2011 ,Journal of Medical Case Reports,Case Report on Trial: Do You Swear to Tell the Truth?,"This editorial ponders the value of case reports. Can the medical community learn from one case? The answer--a resounding ""yes."""
June 2011 ,Nanomedicine,Future of Nanomedicine: Obstacles and Remedies,"Although nanomedicine has the potential to revolutionize treatment for many diseases, it faces challenging economic, social and safety-related obstacles."
June 2011 ,Future Microbiology,Therapeutic Options for Enterobacteriaceae Infections,Carbapenem resistance in Enterobacteriaceae is rapidly becoming a serious problem. What other therapeutic options are available--and under investigation--to combat these infections?
May 2011 ,American Nurse Today,Drug Therapy Gets Personal With Genetic Profiling,Understanding the effects of genetic variations on drug metabolism is the key to personalized drug therapy. This article will bring you up-to-speed in a hurry.
June 2011 ,Journal of the National Cancer Institute,Radiologists Urge FDA To Accept PET-Based Criteria ,The FDA has accepted only CT scans and Response Evaluation Criteria in Solid Tumors/RECIST to date. What clinical impact might such a change have?
June 2011 ,Personalized Medicine,Stem Cells in Drug and Toxicological Screening,Can stem cells be used to determine drug safety?
June 2011 ,Headache,Evaluating Sex and Gender in Migraine and Headache Research,"Several hypotheses have been proposed to explain the sex differences observed in migraine and other headache disorders, and numerous studies conducted, but how valid are their findings?"
June 2011 ,Journal of Cardiovascular Electrophysiology,Trends in Rhythm Control Therapies After AFFIRM and RACE Trials,Significant utilization changes were observed in the years following the publication of the AFFIRM and RACE trials. What has the net effect been?
May 2011 ,Expert Review of Clinical Pharmacology,Targeting NMDA Receptors for Treatment of Neuropathic Pain,New research may facilitate drug development for neuropathic pain.
May 2011 ,IRB: Ethics & Human Research,Parents' Understanding and Recall of Informed Consent,How well do people really understand the concept of informed consent in the context of clinical research? This study takes a look.
May 2011 ,Journal of the National Cancer Institute,Invasive Ipsilateral Breast Tumor Recurrence After Lumpectomy,Breast conserving surgery for DCIS may be more effective when combined with adjuvant therapies.
April 2011 ,Immunotherapy,Potential Targets for Pancreatic Cancer Immunotherapeutics,Immune-based treatments for cancer represent a rapidly evolving treatment option with great potential.
May 2011 ,BMC Surgery,Antiplatelet Agents in Surgical Perioperative Management,"For patients on long-term aspirin therapy, do the risks of possible thromboembolic events after withdrawal outweigh the bleeding risks associated with its continuation during the perioperative period?"
May 2011 ,BMC Surgery,Ultrasound-Guided Breast-Sparing Surgery,Can ultrasound-guided breast-conserving surgery provide better cosmetic outcome--and greater accuracy--in breast cancer patients with palpable tumors?
April 2011 ,Journal of the American Geriatrics Society,Antidepressant Studies in People With Depression and Dementia,Is a sugar pill sweeter than the real-deal when it comes to benefits from antidepressant trials in patients with dementia?
April 2011 ,Journal of the National Cancer Institute,Specialty Physician Involvement in Cancer Clinical Trials,Find out what factors are associated with greater physician involvement in cancer-related clinical trials.
November 2011 ,Current Opinion in Rheumatology,Raynaud's Phenomenon and Digital Ischaemic Complications,The networking of clinicians has facilitated key advances in the management of Raynaud's phenomenon.
July 2011 ,Expert Review of Anti-Infective Therapy,Better Late Than Never: Antivirals for Dengue,"Despite estimates by the WHO that one third of the earth’s population is at risk of dengue infection, there is currently no approved vaccine or antiviral available."
October 2011 ,Prostate Cancer and Prostatic Diseases,Managing Metastatic Castration-Resistant Prostate Cancer,"Will new, emerging therapies complement existing treatment options for metastatic castration-resistant prostate cancer?"
October 2011 ,Future Virology,ARV-based Microbicides and Pre-exposure Prophylaxis for HIV,The promising results of both ARV-based microbicides and oral PrEP have given the HIV prevention field a much-needed boost.
October 2011 ,International Journal of Clinical Rheumatology,Certolizumab Pegol in Rheumatoid Arthritis,How safe and effective is Certolizumab Pegol for the treatment of Rheumatoid Arthritis?
October 2011 ,Emerging Infectious Diseases,Global Spread of Carbapenemase-producing Enterobacteriaceae,We believe we are now at the edge of 2 concomitant epidemics of carbapenemase producers worldwide. Is prevention possible?
October 2011 ,Expert Review of Vaccines,Cellular Adjuvants for Therapeutic Vaccines Against Cancer,Various adjuvant products are currently under evaluation as potential candidates for use in cancer vaccines.
October 2011 ,Nature Reviews Endocrinology,Thyroid Cancer Stem Cells,Understanding of the cellular origin of thyroid cancer may help identify therapeutic targets.
October 2011 ,Current Opinion in Allergy and Clinical Immunology,Ocular Surface Damage by Ophthalmic Compounds,A review of the ways to identify and minimize ocular surface damage in patients using chronic eye drop therapies.
October 2011 ,Journal of the National Cancer Institute,Randomized Phase II Trials: A Long-term Investment,The high rate of failure in phase III trials suggest that current phase II trials are not adequately informative. Can the predictive value of phase II trials be improved by utilizing randomization?
October 2011 ,Journal of the American Board of Family Medicine,Change in the Clinical Encounter Following Research Participation,What are the short- and long-term effects on clinician and/or patient behavior after participation in a practice-based research network study?
October 2011 ,Pediatric Critical Care Medicine,FDA Approval for Medications Used in the PICU,Many medications prescribed and administered in pediatric intensive care units may not have FDA approval. What steps should be taken to rectify this problem?
August 2011 ,Pediatric Pharmacotherapy,Use of IV Ketorolac for Postoperative Analgesia in Infants,Is IV ketorolac safe for postoperative analgesia in infants?
September 2011 ,Rheumatology,New Drugs Beyond Biologics in Rheumatoid Arthritis,Blocking intracellular signaling cascades is a promising therapeutic target in rheumatoid arthritis.
September 2011 ,Pharmacotherapy,Revisiting 'Older' Antimicrobials,Some older antibiotics have experienced a 'rebirth' for treatment of multidrug-resistant pathogens.
August 2011 ,International Journal of Clinical Rheumatology,Diagnosis and Management of Sjögren's Syndrome,Sjorgren's syndrome is a common but difficult-to-treat autoimmune disease. The need to explore new therapies is becoming an important issue to overcome.
September 2011 ,Journal of the American College of Cardiology,Influence of Global Region on HF Beta-Blocker Trials,"Globalization of clinical trials represents an advance for researchers and patients, but new challenges come with a geographically diverse patient population."
September 2011 ,Nature Reviews Clinical Oncology,Opportunities and Pitfalls of Cancer Imaging in Clinical Trials,Bruno Morgan discusses advantages and limitations of currently available imaging modalities and highlights the challenges associated with the incorporation of imaging biomarkers into clinical cancer trials.
August 2011 ,Pharmacotherapy,Cancer Immunotherapy: Sipuleucel-T and Beyond,Will this anticancer vaccine change the future of cancer treatment?
August 2011 ,American Journal of Pharmaceutical Education,"Projected Pharmacy Education and Research, 2010 to 2015",Will the economy and healthcare reform alter the numbers of future PharmD graduates and pharmacy residents?
November 2011 ,Current Opinion in Rheumatology,Clinical Trials in Idiopathic Inflammatory Myopathies,Proper evaluation of treatment in IIM is difficult due to the rare and heterogeneous nature of the disease.
December 2011 ,Future Microbiology,Bacterial Type I Signal Peptidases As Antibiotic Targets,New antibiotics with novel mechanisms of action are urgently needed to combat the increasing problem of antibiotic resistance. Could type I signal peptidase be an attractive antibiotic target?
December 2011 ,Nanomedicine,Lipid-based Nanoformulation of Irinotecan,A liposomal delivery system for the antineoplastic drug irinotecan may improve its effectiveness by providing both antivascular as well as antitumor mechanism of activity.
December 2011 ,Laboratory Medicine,A Lab to Support HIV/AIDS Vaccine and Intervention Trials,This article describes the challenges of creating a sustainable cell processing lab for HIV and AIDS-related clinical trials at a rural field site in Africa.
December 2011 ,Journal of Pediatric Psychology,An Ethics Case Study of HIV Prevention Research on Facebook,"While social networking sites are a tempting place to implement a research study involving young people, special effort must be made to pay attention to consent, confidentiality, and security."
November 2011 ,Nanomedicine,Improving Delivery of Nanomedicines to Solid Tumors ,Effectiveness of nanomedicines in cancer therapy is limited by inadequate delivery and transport. This article looks at the role of apoptosis-inducing tumor priming technology in solving this problem.
November 2011 ,International Journal of Impotence Research,The Effect of Simvastatin in Penile Erection,Is simvastatin beneficial in the treatment of erectile dysfunction? The STED trial investigates.
November 2011 ,Personalized Medicine,Drug Approval Challenges in Personalized Treatment,Why is the development of individualized treatment for cancer occurring slowly?
November 2011 ,Nature Reviews Clinical Oncology,The Silent Minority--Unpublished Data on Cancer Care,"Studies that would have had clinical impact if published promptly are coming out of the closet, but may still have an impact . . ."
October 2011 ,Expert Review of Anti-Infective Therapy,Will New Antimicrobials Overcome Resistance?,The spread of resistance among Gram-positive and Gram-negative bacteria represents a growing challenge for the development of new antimicrobials.
November 2011 ,Journal of Pediatric Psychology,Is the Cold Pressor Task Ethically Acceptable in Children?,"The cold pressor task is a commonly used experimental method of inducing pain, but it poses ethical concerns when used with children. How do researchers, children, and parents perceive it?"
September 2011 ,Nature Reviews Cancer,Tumorigenesis: The Origins of Glioma,Liu and colleagues identify oligodendrocyte precursor cells as the cell of origin for glioma that is caused by inactivating mutations in neurofibromatosis.
November 2011 ,Journal of the National Cancer Institute,Development of Experimental Drug Combinations for Cancer,"Despite evidence of improved benefit of combined anticancer agents, the majority drugs are developed as single agents, resulting in substantial failure rates."
September 2011 ,Nature Reviews Cancer,What Does Physics Have to Do With Cancer?,Can the new US National Cancer Institute Physical Sciences-Oncology Centers initiative help us to better understand the complexity of this disease?
November 2011 ,Europace,Management of Atrial Fibrillation Around the World,"Atrial fibrillation is the same worldwide, but treatments and interpretation of guidelines may vary - depending on where you are."
October 2011 ,U.S. Pharmacist,New Drug Review 2011,"These drugs are ""new molecular entities"" -- they contain chemical substances marketed for the first time in the US."
October 2011 ,Nanomedicine,Liposomes As Drug Delivery Systems for the Treatment of TB,Liposome nanocarriers are promising new delivery systems for anti-TB drugs by both intravenous and inhaled routes.
November 2011 ,Expert Review of Neurotherapeutics,Biologics: The Next-Generation Therapeutics for Analgesia?,"Current therapies for the treatment of chronic pain conditions are inadequate, and there's an urgent need for more effective analgesics. Are biologic agents, such as monoclonal antibodies, the answer?"
November 2011 ,Rheumatology,Effectiveness of Tocilizumab for Rheumatoid Arthritis,How safe and effective is tocilizumab for rheumatoid arthritis patients?
February 2012 ,Journal Watch,New Antivirals Show Promise for Hepatitis C Treatment,The findings in this study provide early evidence that the next generation of direct acting antivirals is more potent and effective than currently available agents against hepatitis C infection.
February 2012 ,Future Microbiology,Microcin C: Biosynthesis and Mechanisms of Resistance,The antibiotic microcin C employs a 'Trojan-horse' strategy to facilitate its transport into a bacterial cell. Can it be manipulated to target specific classes of bacteria?
February 2012 ,Future Oncology,Effectiveness Research for Prostate Cancer Radiation Therapy,Comparative effectiveness research defines risks and benefits of radiation modalities for prostate cancer.
February 2012 ,Headache,Clinical Trials 2011: Year in Review,"An overview of multi-center trials of new therapies and novel formulations of previously approved medications for migraine and other common headache disorders, which were conducted in 2011."
February 2012 ,Diabetes,Brain Sensors in Glucose-stimulated Insulin Secretion,Is this a possible new area of drug development for type 2 diabetes mellitus?
February 2012 ,Diabetes Care,When is Diabetes Distress Clinically Meaningful?,Read about a diabetes distress scale categorized by biologic and behavioral variables.
February 2012 ,Expert Review of Dermatology,Immunotherapy for Melanoma,Immunotherapy may be the best weapon against advanced melanoma. This overview of immune therapeutics for melanoma discusses the many promising agents currently in use or under investigation.
December 2011 ,Annals of Clinical Microbiology and Antimicrobials,Antimutagenic and Antioxidant Effects of Accacia salicina,"The authors examine the potential antioxidant and antimutagenic effects of leaf extracts from Accacia salicina, a species of Acacia tree."
February 2012 ,Journal Watch,Dexpramipexole in ALS: Cautious Optimism,Might the experimental drug dexpramipexole slow disease progression in ALS? Results of a Phase II trial are promising.
February 2012 ,Journal of the American Board of Family Medicine,A Randomized Colorectal Cancer Screening Intervention Trial,"This article recounts the challenging and sometimes onerous aspects of conducting a practice-based, randomized colorectal cancer screening intervention trial."
January 2012 ,Pharmacogenomics,Pharmacogenetics of Drugs Withdrawn From the Market,Advances in pharmacogenomics have elucidated the influence of genetic factors on drug metabolism and efficacy. This review examines how genetics impacted safety issues with several drugs.
January 2012 ,AIDS,Apparent Declining Efficacy in Randomized HIV Trials,This article discusses the trends in recent HIV clinical trials.
January 2012 ,Nanomedicine,Mesoporous Silica Nanoparticles in Targeted Cancer Therapy,"This report looks at the therapeutic efficacy and safety of mesoporous silica nanoparticles, inorganic particulates under investigation as a drug delivery mechanism for targeted cancer therapy."
January 2012 ,Arthritis Research & Therapy,Disturbance of Cytokine Networks in Sjogren's Syndrome,New insights into interconnected cytokines in primary Sjogren's syndrome may lead to new treatments.
January 2012 ,Rheumatology,Tocilizumab: A Novel Therapy for Large-vessel Vasculitis,Is tocilizumab an effective treatment option for large-vessel vasculitis?
January 2012 ,Personalized Medicine,Healthcare Payers: Gate or Bridge to Personalized Medicine?,"According to healthcare payers, what are the benefits of pharmacogenomics?"
January 2012 ,Expert Review of Molecular Diagnostics,Development of Diagnostics for Neuropsychiatric Disorders,Diagnostic advances for neuropsychiatric disorders will best be accomplished through the development of biomarkers--but a better understanding of the underlying molecular mechanisms must come first.
December 2011 ,Nature Reviews Clinical Oncology,A Personal Note--40 Years After the Cancer Act,"The Cancer Act had a mandate ""to support research and the application of the results of research, to reduce the incidence, morbidity and mortality from cancer."" Has it been effective?"
November 2011 ,IRB: Ethics & Human Research,When Is It Ethical to Withhold a Research Incentive?,Is it fair for institutional review boards (IRBs) to offer incentives to survey participants? This commentary looks at the issue.
December 2011 ,Journal of the National Cancer Institute,Company Stock Prices Related to Oncology Drugs,How do public announcements regarding experimental anticancer drugs affect stock prices?
April 2012 ,Breast Cancer Research,MicroRNA Let-7a Suppresses Breast Cancer Cell Migration ,Learn about the therapeutic potential of let-7a as an antitumor and antimetastatic manager in breast cancer patients.
April 2012 ,International Journal of Epidemiology,Commentary: The Seven Plagues of Epigenetic Epidemiology,"The authors of this commentary identify seven critical biological, technical and methodological issues that may complicate--and confound--epigenetic study results."
March 2012 ,Expert Review of Clinical Pharmacology,Drug Development: Lessons From an Undeveloped Drug,What makes a drug successful in the marketplace?
April 2012 ,International Journal of Clinical Practice,New Therapies for Chronic Hepatitis C Infection,Over 40 new treatment options are undergoing clinical trials for the treatment of hepatitis C virus. Which look to be the most promising?
April 2012 ,Diabetes,Preventing Beta-Cell Loss and Diabetes With CCBs,Will this research change the future of diabetes therapy?
February 2012 ,Annals of Clinical Microbiology and Antimicrobials,Antimicrobial Activity of Sida Alba L. (Malvaceae) ,"An overview of the in vitro antimicrobial activity of Sida alba L, an herb in the Malvaceae family used in traditional African medicine. Is it effective against drug-resistant bacterial strains?"
April 2012 ,Expert Review of Neurotherapeutics,A Novel Treatment for Glioblastoma: Integrin Inhibition,The prognosis for the majority of patients with glioblastoma remains discouraging. This review focuses on the potential of anti-integrin strategies as a promising therapeutic option.
April 2012 ,Diabetes,Postprandial Intranasal Insulin Intensifies Satiety,Is insulin an effective treatment for food overconsumption?
April 2012 ,Expert Review of Anti-Infective Therapy,Immunomodulatory Effects of Antimicrobial Agents. Part II,Antiparasitic and antifungal agents have both deleterious and beneficial immunomodulatory properties. What does this mean for treatment?
April 2012 ,Journal of the American Geriatrics Society,Exclusion of People With Dementia From Geriatrics Research,Are persons with cognitive impairment being excluded from the very clinical research which may help them--without rationale or justification?
March 2012 ,Expert Review of Anti-Infective Therapy,Immunomodulatory Effects of Antimicrobial Agents. Part I,"What do the past, present, and future hold for antibacterial and antiviral agents?"
March 2012 ,Future Neurology,Emerging Strategies for the Treatment of Multiple Sclerosis,"An overview of emerging methodologies in the fight against multiple sclerosis, highlighting strategies for prevention through immune modulation, and repair via neuroprotection and remyelination."
March 2012 ,Journal of the National Cancer Institute,Sipuleucel-T in Castration-resistant Prostate Cancer,The lack of demonstrable tumor responses has prompted calls for scrutiny of the trial design for sipuleucel-T. What are the lessons learned and how will our understanding of related trials for late-stage prostate cancer be improved?
March 2012 ,Pharmacogenomics,Pharmacogenetics of Antidepressant Drugs,This review summarizes recent progress in isolating biomarkers which might predict which patients will have the greatest benefit from antidepressant therapy for depression and other mood disorders.
March 2012 ,Pacing and Clinical Electrophysiology,"ICDs, Guidelines, and National Registries",Are we thoroughly mining the ICD device registry data -- to systematically improve outcomes?
March 2012 ,HIV Medicine,New ART Drugs in Treatment-experienced HIV-infected Patients,What is the efficacy of new ART drugs in treatment-experienced patients?
March 2012 ,Expert Review of Clinical Pharmacology,Communicating Clinical Trial Results to Study Volunteers,Will improving patient communication improve clinical trial recruitment?
March 2012 ,Brain,Herbalism Helps Headache,This short commentary highlights some novel therapeutic agents derived from natural sources that may prove to be effective against migraine and other forms of headache.
March 2012 ,American Journal of Kidney Diseases,New Anemia Therapies: Novel Strategies From Bench to Bedside,What are some of the newer therapies on the horizon for treating anemia of chronic kidney disease? This study looks at some of the options beyond erythropoietin.
February 2012 ,Arthritis Research & Therapy,Use of Administrative Claims Data for RA Treatment Research,A claims-based algorithm to evaluate the clinical effectiveness of rheumatoid arthritis medications seems promising.
June 2012 ,AIDS Clinical Care,Efavirenz Better than Nevirapine for Most Patients,"For most patients, efavirenz is preferred over nevirapine, but why?"
June 2012 ,American Heart Journal,ACE Inhibitors and ARB Blockers for Ischemic Heart Disease,Learn more about the comparative effectiveness of ACE-I/ARB in patients with or at high risk for stable ischemic heart disease.
May 2012 ,Pediatric Pharmacotherapy,Intranasal Ciclesonide for Allergic Rhinitis in Children,Could the new ciclesonide HFA intranasal spray become a useful tool for allergic rhinitis in children?
June 2012 ,Arthritis Research & Therapy,Meryl Streep and the Problems of Clinical Trials,Performing clinical trials can get complex. What went wrong in this trial of lupus nephritis patients?
June 2012 ,Diabetes,Scientific Achievement Award 2011: Defeating Diabesity,What if a drug could treat both diabetes and obesity? You might be surprised at the latest in research and drug development.
June 2012 ,American Heart Journal,Central Blood Pressure for Guiding Hypertension Management,Will central BP management prove to be feasible -- in terms of patient outcomes?
June 2012 ,Aging Health,Elderly Women With Heart Failure: Simply Forgotten?,"Elderly women represent a good portion of heart failure patients, and yet they receive little attention compared to men--usually excluded from clinical research, and often under-treated."
May 2012 ,Arthritis Research & Therapy,"Safety, Pharmacokinetics, and Activity of Pateclizumab",Pateclizumab may provide an attractive alternative therapeutic approach for patients with moderate to severe RA.
May 2012 ,Future Oncology,Asians vs Caucasians - Lung Cancer and Systemic Therapy,"For lung cancer treatment, find out why ethnicity may make all the difference in the design and conduct of a global clinical study."
May 2012 ,Current Opinion in Allergy and Clinical Immunology,Vitamin D Supplementation and the Allergy Pandemic,What does a link between vitamin D supplementation and allergy mean for the masses who are vitamin D deficient?
May 2012 ,Diabetes,A Human Monoclonal Antibody That Improves Glycemic Control,Learn about a new mAb that shows promise for diabetes management.
May 2012 ,Expert Review of Molecular Diagnostics,Functional Drug-gene Interactions in Lung Cancer,"Utilizing lung cancer as an example, the authors outline the principles that govern drug sensitivity and resistance from a genetic perspective."
May 2012 ,Future Microbiology,How Mycobacterium Tuberculosis Goes to Sleep,"Ten years ago, the underlying genetic program that allows M. tuberculosis to develop a drug-tolerant dormant form was identified. What have we learned since--and what challenges remain?"
May 2012 ,Journal of the American College of Cardiology,Personalized Medicine for Devices,The lack of a uniform response to cardiac resynchronization therapy may indicate the need for a more tailored approach -- among patients who meet criteria for biventricular pacing. . .
April 2012 ,Nanomedicine,"Nanomedicine, Cancer Stem Cells, and Drug Resistance","Cancer stem cells, or tumor-initiating cells, are responsible for resistance, metastasis and relapse of cancers. Can metastatic and cancer stem cells be targeted with nanomedicine-based strategies?"
April 2012 ,Pediatric Pharmacotherapy,Ivacaftor for Cystic Fibrosis and the G551D-CFTR Mutation,Ivacaftor represents a significant breakthrough for patients with CF.
April 2012 ,Expert Review of Hematology,Immunotherapy Highlights From American Society of Hematology,"Read about immunotherapy studies presented at the American Society of Hematology annual meeting on such topics as T-cell function, tumor antigen targeting, and more."
April 2012 ,Future Virology,Introducing Yesterday's Phage Therapy in Today's Medicine,"Could phages, the viruses that kill bacteria, help fight antibiotic-resistant bacteria?"
April 2012 ,Future Oncology,Systemic Treatment of Malignant Pleural Mesothelioma,Malignant pleural mesothelioma is a rare malignancy with a dismal prognosis. Find out what therapeutic strategies are on the horizon.
April 2012 ,Journal of the National Cancer Institute,CYP2D6 Genotype in Postmenopausal Women,"In this editorial, 2 breast cancer specialists comment on 2 studies that apparently refute the utility of CYP2D6 as a marker for the benefit of tamoxifen. Why has such a good theory gone wrong?"
August 2012 ,BMC Urology,Designing the Selenium and Bladder Cancer Trial (SELEBLAT),"The SELEBLAT trial investigates the effect of selenium on the recurrence of bladder cancer, with first results due in 2014."
July 2012 ,Schizophrenia Bulletin,Psychiatry and the Pharmaceutical Industry,"Is innovation in psychopharmacology at a standstill? In this editorial, the author examines the challenges facing the development of new psychiatric drugs."
August 2012 ,Neurosurgical Focus,Wisconsin Spine Outcome Study-Pilot,The Wisconsin Spine Outcome Study-Pilot presents a mechanism for establishing comparative effectiveness of currently prevalent treatments for degenerative lumbar disease utilizing a patient registry.
August 2012 ,Journal of Participatory Medicine,The Impact of Open Access and Social Media on Research,"Two trends, open access and social media, are changing the peer review process. Is research quality being adversely affected?"
August 2012 ,Neurosurgical Focus,Meta-analysis of Diagnostic Test Accuracy in Neurosurgery,This paper aims to improve neurosurgeons' familiarity with the meta-analysis of diagnostic test accuracy. What are the steps for conducting a systemic review?
August 2012 ,Journal of the American Board of Family Medicine,Azithromycin for Bronchial Asthma in Adults,How effective is azithromycin in treating chronic asthma in adults?
August 2012 ,Journal of the National Cancer Institute,The Role of Cancer Research in Noncommunicable Disease,The cancer research community needs to be fully engaged with developments following the UN meeting on noncommunicable diseases. Are you there yet?
August 2012 ,Diabetes,Steady-State Brain Glucose Levels During Hypoglycemia,Why are patients with T1DM at risk for hypoglycemia?
August 2012 ,Neurosurgical Focus,Comparative Effectiveness in Neurosurgery: Why It Matters,"Why should a neurosurgeon care about comparative effectiveness? In this article, the author outlines the rationale of comparative effectiveness and illustrates how it applies to neurosurgical topics."
August 2012 ,Expert Review of Dermatology,Topical Agents and Emerging Perspectives in Psoriasis,"This comprehensive review highlights the most effective topical agents for psoriasis, focusing on promising topical drugs that are currently under investigation."
July 2012 ,The Annals of Pharmacotherapy,CFTCR-Modifying Medications: The Future of CF Treatment,Read about new targeted agents available for CF.
July 2012 ,Neurosurgical Focus,An Alternative Approach to Comparative Effectiveness Research,"Are legislative constraints limiting the utility of comparative effectiveness research? This editorial highlights the limitations of the current approach to CER in the US, and proposes an alternative."
July 2012 ,Emerging Infectious Diseases,Trichomonas Vaginalis Antimicrobial Drug Resistance,"To avoid the emergence of antimicrobial drug resistance, novel treatment options are needed for the treatment of Trichomonas vaginalis."
July 2012 ,IRB: Ethics & Human Research,Women's Views About Participating in Research While Pregnant,"How can pregnant women be encouraged to participate in clinical research studies? Is it generally safe for them, in most circumstances?"
August 2012 ,HIV Medicine,The MONET Trial: DRV/r Monotherapy vs. DRV/r Plus Two NRTIs,DRV/r monotherapy or DRV/r plus two NRTIs? Is one treatment plan more effective than the other?
July 2012 ,Pediatric Pharmacotherapy,New Options for Eradicating Resistant Head Lice,New head lice treatments may be safer and more effective.
June 2012 ,Personalized Medicine,Genomic Medicine in Atherosclerotic Cardiovascular Disease,Can pharmacogenomics predict who is at risk for MI?
June 2012 ,Arthritis Research & Therapy,The Future of CCR5 Antagonists in Rheumatoid Arthritis,Are CCR5 inhibitors useful in the treatment of rheumatoid arthritis?
June 2012 ,Diabetes,Recent Clinical Trials to Preserve B-Cell Function in T1DM,Can pharmacologic interventions delay development of type 1 diabetes? Learn what critical lessons research has taught us.
May 2012 ,IRB: Ethics & Human Research,Perspectives on Genotype-driven Research Recruitment,What are the specific ethical issues involved in genotype-driven research recruitment?
October 2012 ,Diabetes Care,Effects of Soy Milk in Diabetic Patients With Nephropathy,Will soy milk improve renal function in patients with diabetic nephropathy?
September 2012 ,Newborn & Infant Nursing Reviews,Pain Interventions in Premature Infants,What's the best evidence for safe and effective pain management in the NICU?
October 2012 ,Cardiovascular Diabetology,Low Amylase: Association With Insulin and Insulin Resistance,Is low amylase a cardiometabolic risk factor?
October 2012 ,BMC Emergency Medicine,Trial: Immediate Total-Body CT Scanning in Trauma Patients,How beneficial is immediate total-body CT scanning in severely injured trauma patients? The REACT-2 trial investigates.
September 2012 ,IRB: Ethics & Human Research,"Consent for Invasive, Nondiagnostic Research Procedures","How important is it for patients to give informed consent when invasive, nondiagnostic procedures are used in clinical research? This new article explains."
October 2012 ,Nanomedicine,Nanoparticles as a Drug Delivery System,"Nanotechnology has the potential to revolutionize drug delivery, but challenges remain. This article summarizes recent developments in the use of nanoparticles as drug delivery systems."
May 2012 ,BMC Musculoskeletal Disorders,"Total Knee Replacement and Physical, Medical Therapy",Is TKA more effective when combined with non-surgical treatments? The MEDIC-study investigates.
September 2012 ,Expert Review of Clinical Immunology,Current Treatments of Rheumatoid Arthritis,How do rheumatoid arthritis outcomes from Japan differ from those in other nations?
September 2012 ,Cardiovascular Diabetology,Preventing T2DM: Study Protocol for Educational Intervention,Read about a clinical trial evaluating intensive education for diabetes prevention.
September 2012 ,Personalized Medicine,Benefit-Risk Management in Personalized Healthcare,Is the healthcare system ready to adapt to pharmacogenomics?
September 2012 ,Diabetes,Fully Integrated Artificial Pancreas in Type 1 Diabetes,Read about new research designed to modulate insulin delivery in real time.
September 2012 ,Expert Review of Vaccines,Prostate Cancer Vaccines in Clinical Trials,What is the future for prostate cancer treatment through vaccine immunotherapy?
May 2012 ,Cardiovascular Diabetology,Ginkgo biloba Reduces Glucose-Induced Endothelial Adhesion,Can this herbal antioxidant reduce the risk of atherosclerosis?
September 2012 ,American Heart Journal,Under-reporting of Cardiovascular Events in the Rofecoxib Alzheimer Disease Studies,Learn more about avoiding potential drug risks in clinical trials.
September 2012 ,Future Microbiology,Plant-Derived Antimicrobial Compounds,"With the problem of antibiotic resistance ever-increasing, finding effective alternatives is crucial. Could medicinal plants provide the answer?"
September 2012 ,Nanomedicine,Crossing the Blood-Brain Barrier: Nanotechnology Strategies,"Nanotechnology may be the key to opening the gate of the blood brain-barrier, providing a significant advantage over currently used drug delivery strategies for brain cancers and other CNS disorders."
September 2012 ,Diabetes,Intranasal Insulin Suppresses Food Intake,Is intranasal insulin a therapeutic option for weight loss?
August 2012 ,Future Virology,Eight Common Misconceptions About HIV Vaccines,Are misconceptions about HIV vaccines impeding our progress in controlling the AIDS epidemic?
August 2012 ,Future Neurology,Generation of Human Neurons and Neural Stem Cells,"Stem cell therapies could have a significant impact on worldwide public health, but techniques for generating neurons and neural stem cells may have risks."
August 2012 ,Neurosurgical Focus,Comparative Effectiveness Research in Neurotrauma,"Injuries to the nervous system are common and have potentially devastating consequences, yet many challenges exist in determining best management. How can comparative effectiveness be utilized?"
November 2012 ,Future Oncology,HAMLET: Functional Properties and Therapeutic Potential,This HAMLET is no tragedy but it does kill tumor cells -- with high selectivity.
November 2012 ,Expert Review of Anti-Infective Therapy,Targeting Antibiotic Resistance in M. tuberculosis,Drug-resistant M. tuberculosis strains pose a serious threat to public health.
November 2012 ,AccessMedicine from McGraw-Hill,A Promising New Oral Agent for the Treatment of MS,"The first widely used oral agent for MS was approved for use just 2 years ago. This brief review reports on two studies showing that another investigational oral drug, BG-12, is safe and effective."
November 2012 ,American Heart Journal,Pediatric Cardiovascular Safety,Pediatric drug and device development may use adult data but often requires additional preclinical and clinical testing. Is this enough to protect kids?
November 2012 ,Expert Review of Hematology,Anti-tumor Immunity After Allogeneic HCT,Find out more about the development of novel post-HCT therapies for patients who are at high risk for disease recurrence following HCT.
November 2012 ,The British Journal of Dermatology,Which Outcomes Should We Measure in Vitiligo?,"There's little consensus around methods of assessment and outcome measures for vitiligo, making it difficult to compare trial results. What outcomes do patients and clinicians consider important?"
October 2012 ,The Journal of Invasive Cardiology,Appropriate Timing of Nitroglycerin Prior to IVUS,"Intravascular ultrasound facilitates assessment of coronary plaque severity, but how does nitroglycerine administration timing impact results?"
October 2012 ,Expert Review of Clinical Immunology,Clinical Trials of Sublingual Immunotherapy,"Most of the experience with sublingual immunotherapy (SLIT) comes from Europe, so is SLIT finally gaining traction in the US?"
October 2012 ,Nanomedicine,Nanostructuring Molecular Materials for Drug Delivery,Compressed fluid-based technology is a promising novel technique in the preparation of solid micro- and nanoparticles and vesicles as drug delivery systems.
October 2012 ,Respiratory Research,Effect of Budesonide/Formoterol Maintenance on Severe Asthma,Budesonide/formoterol is used as both maintenance and reliever therapy. How does it stack up to standard therapy for severe asthma?
October 2012 ,Schizophrenia Bulletin,Twenty-five Years of Glutamate in Schizophrenia,This brief commentary reviews the PCP model of schizophrenia and its relation to NMDA agonists and antagonists. Can these dissociative anesthetics translate into effective clinical treatments?
October 2012 ,Headache,A Sumatriptan Transdermal System for Acute Migraine,"Migraine is often accompanied by nausea, and oral medications may be difficult to stomach. A transdermal sumatriptan patch, currently undergoing clinical trials, may be the answer."
September 2012 ,Expert Review of Obstetrics & Gynecology,Histone Deacetylase Inhibitors for Endometriosis,"What are some of the latest drug therapies currently in development for endometriosis, and how promising are epigenetic drugs for the potential treatment of this debilitating gynecologic condition in women?"
October 2012 ,Spine,Early Initiation of Rehabilitation After Lumbar Spine Fusion,How does early initiation of rehabilitation affect outcomes after lumbar spinal fusion?
October 2012 ,Diabetes Care,Targets and Tactics for High-Risk Patients With T2DM,What did we learn from trials investigating intensive treatment of hyperglycemia in T2DM?
October 2012 ,Diabetes,"BNP Modulates Ghrelin, Hunger, and Satiety in Healthy Men",Does this heart failure hormone have anorectic properties?
October 2012 ,Nanomedicine,Magnetic Nanoparticles for Locally Targeted Therapy,This review examines the use of magnetic nanoparticles for drug delivery which requires penetration of a cellular barrier. What strategies might improve the efficacy of targeting?
October 2012 ,Pharmacogenomics,Epigenetic-Dependent Regulation of Drug Metabolism,"Gene expression encoding drug transporters and drug-metabolizing enzymes are highly variable between individuals, leading to large variations in drug response. How does epigenetics factor in?"
August 2012 ,Expert Review of Cardiovascular Therapy,Safety of Inhibition of Cholesteryl Ester Transfer Protein,Learn more about an experimental strategy for increasing HDL-C levels to decrease atherosclerosis.
October 2012 ,Diabetes,Chronic Exercise Attenuates Lipid-Induced Insulin Resistance,Why does exercise reduce the risk of type 2 diabetes?
December 2012 ,BMC Urology,IV Lidocaine vs IV Morphine for Renal Colic in the ED,How does IV lidocaine compare with IV morphine in pain reduction of renal colic patients treated in the ED?
December 2012 ,Current Opinion in Rheumatology,New Treatment Strategies in Large-vessel Vasculitis,Will biologics have a place in the treatment of large-vessel vasculitis?
December 2012 ,Cardiovascular Diabetology,Postprandial Endothelial Function in Normal Glucose,Research evaluates the relationship between insulin levels and vascular endothelial function.
December 2012 ,Expert Review of Pharmacoeconomics & Outcomes Research,Demand for Male Contraception,Why aren't pharmaceutical companies developing hormonal contraceptives for men?
December 2012 ,Expert Review of Vaccines,Chikungunya Virus and Prospects for a Vaccine,There are several vaccine candidates in preclinical and clinical development for the Chikungunya virus.
December 2012 ,Annals of Clinical Microbiology and Antimicrobials,Antibacterial Activity of Plasma From Crocodile,Alligators and crocodiles are remarkably resistant to microbial infection. Might they be a source of a novel naturally occurring antibacterial agent?
December 2012 ,Personalized Medicine,Personalizing Rare Disease Research,How will exome sequencing improve diagnosis of rare diseases?
December 2012 ,American Heart Journal,Erythropoietin Treatment in Patients With AMI,Is there a relevant role for erythropoietin in treating patients with myocardial infarction?
December 2012 ,Seminars in Neurology,ALS: Drug Therapy From the Bench to the Bedside,"The pathophysiology of ALS remains poorly understood, and only one drug has been shown to enhance survival. This article reviews hypotheses regarding the genesis of ALS and potential new therapies."
December 2012 ,Expert Review of Anti-Infective Therapy,Targeting Drug Tolerance in Mycobacteria,Is biofilm formation a survival strategy of M. tuberculosis in chronic TB infection?
October 2012 ,Nanomedicine,Nanodelivery Strategies in Cancer Chemotherapy,"Drug delivery continues to be a stumbling block in safe and efficacious cancer chemotherapy, but revolutionary developments in nanotechnology are paving the way for better delivery systems."
December 2012 ,International Journal of Impotence Research,Losartan Improves Erectile Dysfunction in Diabetic Patients,Is losartan alone effective in treating erectile dysfunction in diabetics -- or is combination therapy with tadalafil more beneficial?
December 2012 ,Annals of Clinical Microbiology and Antimicrobials,In Vitro Antimicrobial Activity of Cryptolepis sanguinolenta,"Cryptolepis sanguinolenta, a plant mostly found in the tropical rain forest regions of Africa, demonstrated significant antimicrobial activity in this study."
December 2012 ,Expert Review of Vaccines,A Therapeutic Vaccine for Human Chagas Disease,Heart disease caused by Chagas disease could be prevented or significantly delayed with the Chagas vaccine.
November 2012 ,Arthritis Research & Therapy,B Lymphocyte-Typing for Predicting Response to Rituximab,Can B lymphocte-typing identify non-responders to rituximab ahead of time?
November 2012 ,BMC Neurology,Masitinib Treatment in Patients With Progressive MS,"Treatment options for patients suffering from progressive forms of multiple sclerosis are few. Masitinib, an oral tyrosine kinase inhibitor, showed promise in this exploratory trial."
November 2012 ,BMC Musculoskeletal Disorders,Use of a Minimalist Footwear vs Habitual Shoe in Knee OA,Long-term use of minimalist shoes may be an effective and inexpensive treatment option for knee OA.
November 2012 ,American Heart Journal,Cardiovascular Outcomes in BARI 2 Diabetes Trial,What are the risks associated with an abnormal ankle-brachial index in patients with type 2 diabetes and stable coronary artery disease?
November 2012 ,Expert Review of Clinical Pharmacology,Novel Therapeutics for Gastroesophageal Reflux Symptoms,Up to 30% of patients with GERD have inadequate relief with PPIs. Are new and better drugs in development?
November 2012 ,Skin Therapy Letter,Device-Based Therapies for Onychomycosis Treatment,"Device-based therapies such as lasers, photodynamic therapy, iontophoresis, and ultrasound are promising solutions for the treatment of onychomycosis."
February 2013 ,Immunotherapy,Immune Modulators as Adjuncts in Invasive Fungal Infections,"Antifungal immunotherapy now includes age-old interventions as well as promising experimental techniques, but transition from the bench to clinical-phase studies just isn't keeping pace. . ."
October 2012 ,Interventional Cardiology,"CAS, CREST and AHA Guidelines for Treating Carotid Stenosis",Just how equivalent are carotid artery stenting and carotid enderterectomy?
February 2013 ,Future Virology,Development of SARS Vaccines and Therapeutics Still Needed,The development of vaccines and therapeutics for the prevention and treatment of SARS is still an urgent issue that needs to be addressed.
February 2013 ,Nanomedicine,EGF Receptor-Targeted Nanocarriers for Cancer Treatment,The utilization of EGF receptor targeting to enhance delivery of chemotherapeutic and diagnostic agents to EGFR-overexpressing cancers is a novel and promising strategy in nanomedicine.
February 2013 ,Annals of Oncology,Ipilimumab in Combination With Paclitaxel and Carboplatin in SCLC,This study enrolled patients with ED-SCLC as well as those with advanced NSCLC. Results for the ED-SCLC cohort are presented here.
February 2013 ,Future Microbiology,Developing Oral Probiotics From Streptococcus salivarius,"S. salivarius, the principal bacterium colonizing the oral cavity, shows promise as a probiotic for control of a variety of infections, from halitosis and dental caries to otitis media and candida."
January 2013 ,Expert Review of Clinical Pharmacology,Modeling Schizophrenia: Uncovering Novel Therapeutic Targets,Learn about animal modeling strategies being used to discover novel therapies for schizophrenia.
January 2013 ,Malaria Journal,New Medicines for the Control and Elimination of Malaria,What is on the horizon for new therapies in the treatment of malaria?
January 2013 ,Pharmacogenomics,Improving Clinical Trial Sampling for Future Research,"Challenges and recommendations for collecting adequate, representative samples for pharmacogenomic and future research in global trials are identified by the Drug Information Association."
January 2013 ,The Journal of Invasive Cardiology,The RESPECT Trial,"What are the pros and cons of patent foramen ovale closure, when compared to medical management?"
January 2013 ,Diabetes,Role for DPP4 in Obesity-Induced Visceral Inflammation,Does DPP-4 regulate adipose inflammation in obesity?
January 2013 ,BMC Endocrine Disorders,Effect of Eplerenone on Parathyroid Hormone Levels in Patients With Primary Hyperparathyroidism,Can this mineralocorticoid receptor antagonist reduce PTH secretion?
January 2013 ,Critical Care,7-day Doripenem vs 10-day Imipenem-Cilastatin for VAP,Which VAP treatment course has better outcomes? The results might surprise you.
January 2013 ,Health and Quality of Life Outcomes,The Anti-Clot Treatment Scale (ACTS) in Clinical Trials,"This study evaluated the reliability and validity of the Anti-Clot Treatment Scale, a patient-reported instrument to assess satisfaction with anticoagulant treatment for venous thromboembolism."
January 2013 ,Diabetes,Levels of Fetuin-A and Hepatic Enzymes and Risk of T2DM,Is this glycoprotein associated with diabetes risk?
January 2013 ,BMC Musculoskeletal Disorders,Return to Work in Sick-Listed Employees With Low-Back Pain,Is there a difference in sick leave relapse in those receiving brief vs multidisciplinary intervention for low-back pain?
January 2013 ,Journal of Pediatric Psychology,Ethical Guidance for Pediatric e-health Research,"E-health research is a fast-growing research tool in pediatric psychology, but there is little pragmatic guidance as to ethical best practice. This article aims to provide ethical guidelines."
January 2013 ,Clinical Endocrinology,Diet Habits and Their Relationship With Metabolism in PCOS,How are hormone levels affected by diet in patients with PCOS?
January 2013 ,BMC Endocrine Disorders,Association of ALT With the Hepatic Insulin Resistance Index,Can ALT be used to evaluate hepatic insulin resistance?
December 2012 ,Personalized Medicine,Why Personalized Medicine Will Fail If We Stay the Course,Is research in individualized medicine taking all ethnicities into consideration?
April 2013 ,BMC Family Practice,Family Physicians' Diagnostic Gut Feelings Are Measurable,Can 'gut feeling' in diagnostic reasoning be measured by means of a questionnaire?
April 2013 ,Journal of the American College of Cardiology,CardioMEMS Champion Heart Failure Monitoring System,Find out why the FDA is taking a cautious approach with a new therapy that could help patients with heart failure to stay in tune.
April 2013 ,The Annals of Pharmacotherapy,Use of Number Needed to Treat in Cost-Effectiveness Analyses,Values like number needed to treat and number needed to harm are easily understood. Should health care economic studies use more of such measures?
April 2013 ,Rheumatology,"Osteoclast Migration, Differentiation and Function",How will osteoclast-targeted therapies impact future treatment of RA?
April 2013 ,Expert Review of Neurotherapeutics,Individual Treatment Response in ADHD,Key to addressing the treatment needs of patients with ADHD is the development of psychometrically validated instruments to measure treatment response.
April 2013 ,Journal of the National Cancer Institute,Radiotherapy Protocol Deviations and Clinical Outcomes,How do radiotherapy protocol deviations in clinical trials affect treatment failure and overall mortality?
April 2013 ,The Annals of Pharmacotherapy,Protocol Design on Outcomes in RA Treated With Rituximab,Does rituximab produce sustained remissions in RA?
March 2013 ,Expert Review of Clinical Pharmacology,Polypharmacology: Drug Discovery for the Future,Drug molecules may interact with many targets causing adverse effects. How is drug design reducing this risk?
March 2013 ,Future Neurology,Peptidergic Drugs for Treatment of Traumatic Brain Injury,"Cerebrolysin, a peptidergic drug with neuroprotective and neurorestorative properties, presents a novel, multimodal approach to the treatment of traumatic brain injury."
March 2013 ,Malaria Journal,Pyronaridine-artesunate Granules for Pediatric Malaria,Are pyronaridine-artesunate granules an effective treatment option for children with P. falciparum malaria?
March 2013 ,Current Opinion in Neurology,Promoting Neuroplasticity and Recovery After Stroke,What do we know about recovery after stroke? This review poses a theoretical framework for new interventions for poststroke rehabilitation in light of current knowledge of neuroplasticity.
March 2013 ,Nanomedicine,Biotargeted Nanomedicines for Cancer,This commentary highlights six critical tenets which will facilitate the successful development of biotargeted nanomedicines for cancer.
March 2013 ,Nutrition and Metabolism,Dietary Protein in Weight Management,"The authors propose two theories, 'protein spread theory' and 'protein change theory' in an effort to explain discrepancies in clinical studies regarding the effect of protein intake on body weight."
March 2013 ,Pharmacogenomics,Pharmacogenomics: A Bridge to Individualized Cancer Therapy,Pharmacogenomics has the potential to revolutionize anticancer drug development by reducing life-threatening toxicity and improving therapeutic efficacy. This review explores the latest research.
March 2013 ,Respiratory Research,Airway Responses and Inflammation in Subjects With Asthma,How does a rapid-fire approach to bronchial allergen challenges impact research subjects with asthma? What's the clinical message?
February 2013 ,AccessMedicine from McGraw-Hill,Endovascular Treatment Following IV tPA in Acute Stroke,Find out why this trial was halted.
February 2013 ,Future Microbiology,Emergence of Drug-Resistant and Untreatable Gonorrhea,Treatment options for gonorrhea are diminishing rapidly due to antimicrobial resistance. Is an era of untreatable gonorrhea approaching?
February 2013 ,Expert Review of Anti-Infective Therapy,Microbicides for the Prevention of Sexually Transmitted HIV,Can microbicide development aid in the prevention of HIV transmission?
February 2013 ,Clinical Endocrinology,Treatment of Hypovitaminosis D With Cholecalciferol,Does oral vitamin D3 work just as well as intramuscular vitamin D3?
February 2013 ,Critical Care,RCCT of Atorvastatin in Reducing the Severity of Sepsis,Do statin naive patients with sepsis have lower severity of illness with a daily dose of atorvastatin?
July 2013 ,Nanomedicine,Nanoparticles and the Coagulation System: Safety Concerns,"The use of nanoparticles to carry pro- or anticoagulant factors is a promising new area, but may lead to undesirable side effects. How can these be ameliorated?"
June 2013 ,Malaria Journal,"Artesunate-Mefloquine, Partnerships in Drug Development",A safe and efficacious fixed dose combination treatment is now available to treat malaria patients in resource-poor settings.
June 2013 ,Expert Review of Clinical Immunology,Targeting IL-15 in Large Granular Lymphocyte Leukemia,"Waldmann, a pioneer in cytokine biology, reports the first-in-human Phase I trial of Hu-Mikb1."
June 2013 ,Health and Quality of Life Outcomes,Patient-Reported Outcomes With Apremilast for Psoriasis,Apremilast is an investigational drug in clinical trials for treatment of moderate to severe psoriasis. What is its effect on patient-reported outcomes?
June 2013 ,Expert Review of Cardiovascular Therapy,Impact of ACE Inhibition on Mortality in Hypertension Trials,Don't keep an 'ACE in the hole'. Use it first. Find out why.
June 2013 ,Respiratory Research,Clinical Use of Exhaled VOCs in Pulmonary Diseases,"Are there different 'breath-prints' for asthma, lung cancer, COPD, and cystic fibrosis?"
June 2013 ,International Journal of Clinical Practice,Differing Preparations of Glucosamine for Osteoarthritis,"Research into the efficacy of glucosamine for osteoarthritis has proved inconclusive, with varying results. Could different preparations of glucosamine be a cause of inconsistencies among trials?"
June 2013 ,IRB: Ethics & Human Research,Children Enrolled in Parents' Research,Is it ethical for children to be involved in their parents' research studies? This new article takes a close look at the issues.
June 2013 ,Journal of Viral Hepatitis,Virus-Neutralizing Antibodies to Hepatitis C Virus,Will new research in the adaptive immune response help scientists develop a vaccine against hepatitis C?
June 2013 ,BMC Pregnancy and Childbirth,Managing Reduced Fetal Movements After 36 Weeks Gestation,Is a randomised controlled trial of the management of reduced fetal movement feasible in women after 36 weeks gestation?
June 2013 ,Nanomedicine,Nanoparticles and the Blood Coagulation System. Part I,How can nanotechnology be used in the treatment of coagulation disorders? This article reviews recent advances in the understanding of nanoparticle interactions with plasma coagulation factors.
June 2013 ,Current Opinion in Ophthalmology,Glaucoma Therapy and Ocular Surface Disease,What is the most effective way for clinicians to treat glaucoma in patients with ocular surface disease?
June 2013 ,Annals of Clinical Microbiology and Antimicrobials,In vitro Antimicrobial Activity of Artemisia parviflora,"Do extracts of Artemisia parviflora, a plant belonging to the Aster family, have antimicrobial and antioxidant properties?"
May 2013 ,European Heart Journal,Clinical Implications of JUPITER in a Contemporary Population,JUPITER-eligible individuals can't seem to escape the force-field of earthly cardiovascular risks the way cohorts with lower c-reactive protein levels do. Why?
May 2013 ,AccessMedicine from McGraw-Hill,Mipomersen in Homozygous Familial Hypercholesterolemia,"This brief review covers the antisense oligonucleotide mipomersen, an orphan drug and a first-in-class drug for treatment of homozygous familial hypercholesterolemia."
May 2013 ,Brain,Human Prion Diseases,"Therapeutic trials in patients with Creutzfeldt-Jakob disease have been limited, but recent progress in our understanding of prion diseases and new diagnostic techniques opens up new opportunities."
May 2013 ,Nutrition and Metabolism,Biological and Therapeutic Effects of Ortho-Silicic Acid,"Silicon in its bioavailable form of ortho-silicic acid may prove to have potential therapeutic effects for a wide variety of conditions, from Alzheimer's disease to osteoporosis."
May 2013 ,Rheumatology,Targeting Monocytes/Macrophages in the Treatment of RA,Is targeting monocytes/macrophages an effective strategy for treating RA and other autoimmune diseases?
May 2013 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Emergency Physician Turnover and Clinical Trial Planning,How frequent is emergency physician turnover -- and can it negatively impact researchers designing clinical trials?
May 2013 ,American Heart Journal,Evaluation of Drug Effects on Cardiac Conduction,Get current expert opinions on EKG-based safety measurements and how they're affected by different drugs.
September 2013 ,European Heart Journal,Mens Sana In Corpore Sano Revisited,This editorial ponders the credibility of acetylcholinesterase inhibitors as dual action agents for cardiovascular health and cognitive function.
September 2013 ,BMC Musculoskeletal Disorders,Medical Record Abstraction for Orthopedic Research,Can researchers with no medical training reliably abstract medical record information for clinical research?
September 2013 ,AccessMedicine from McGraw-Hill,Riociguat for Thromboembolic Pulmonary Hypertension,Riociguat is the first drug to demonstrate improved hemodynamics and function in patients with chronic thromboembolic pulmonary hypertension.
September 2013 ,Malaria Journal,Open Access Data Online to Advance Malaria Research,"As an aim to advance malaria research, accessible and usable malaria data can now be found online. "
August 2013 ,Pediatric Pharmacotherapy,Therapies for Pulmonary Arterial Hypertension in Children,"This article reviews several recent PAH studies, as well as new therapies for the treatment of PAH in children."
August 2013 ,Expert Review of Endocrinology and Metabolism,Trying to Make a Difference for Those With Type 1 Diabetes,"Mark A. Atkinson, an international leader in type 1 diabetes research, shares his experiences and thoughts about this 'terrible' disease."
August 2013 ,International Journal of Clinical Rheumatology,Therapeutic Targeting of T Cells in Systemic Sclerosis,What is the role of T cells in systemic sclerosis? Will targeting T cells be an effective treatment solution?
August 2013 ,Future Microbiology,Biofilm-Associated Infections: Novel Therapeutic Strategies,This review focuses on recent progress in understanding the mechanisms of biofilm-specific antimicrobial resistance. What innovative anti-biofilm agents are in the pipeline?
August 2013 ,Annals of Clinical Microbiology and Antimicrobials,Antibacterial Activity of a Pseudomonas Strain Against MRSA,This study investigated the potential antibacterial activity of an extracellular compound derived from Pseudomonas aeruginosa. Could it be effective against MRSA?
August 2013 ,Current Opinion in Infectious Diseases,Treatment and Control of Scabies,What options are available for the treatment of scabies?
August 2013 ,Rheumatology,Small Molecules Targeting JAKs in the Treatment of RA,"Find out more about tofacitinib, which is now the first-in-class compound on the market in the USA for the treatment of RA."
July 2013 ,Nanomedicine,Nanotechnological Strategies for Targeting Tumor Vasculature,Tumor vasculature presents an intriguing therapeutic target in a variety of cancers. How might nanotechnology provide strategies for future vascular-targeted therapy?
July 2013 ,AIDS,Dolutegravir in Antiretroviral-naive Adults With HIV-1,"Dolutegravir (DTG) is a newer, potent INI. How effective and tolerable is it in treatment-naïve HIV patients?"
July 2013 ,Annals of Oncology,Attitudes of Patients With Metastatic Breast Cancer Toward Research Biopsies,Do patients with metastatic breast cancer mind when we 'needle' them -- for the benefit of advancing research?
July 2013 ,Future Microbiology,Phage Cocktails and the Future of Phage Therapy,Could 'cocktails' of bacteriophages -- viruses with an ability to infect and kill bacterial cells -- be an effective weapon against antibiotic-resistant bacterial infections?
July 2013 ,BMC Neurology,Biomarkers for Disease Progression in Parkinson's Disease,Do any reliable biomarkers for disease progression in Parkinson's disease currently exist? What characteristics should such a biomarker have?
July 2013 ,Pediatric Pharmacotherapy,Alternative Forms of Oral Drug Delivery for Pediatrics,"Crushing, cutting, and emptying capsules can stop. Innovations in drug delivery technology are leading to new oral alternatives better suited to the pediatric population."
July 2013 ,Rheumatology,Novel Small Molecule Therapeutics in Rheumatoid Arthritis,"Novel therapies are being developed in autoimmune diseases, particularly RA."
July 2013 ,Pharmacogenomics,Personalized Medicine in Oncology,"Despite its promise, actual implementation of personalized medicine into oncology remains limited. What issues still need to be addressed before it can be fully integrated into clinical practice?"
July 2013 ,Current Opinion in Rheumatology,Treatment of Spondyloarthropathy,What new therapies are on the horizon for the treatment of spondyloarthropathy?
December 2013 ,Immunotherapy,Immunotherapy for Pulmonary TB,"With the continuous increasing epidemic of multidrug-resistant TB, new drugs and vaccines are urgently needed."
December 2013 ,Expert Review of Vaccines,Repositioning Therapeutic Cancer Vaccines,The experience with cancer vaccines in the past has been less than rewarding but has provided critical knowledge to help move immunotherapy in cancer forward.
December 2013 ,Diabetes,DCCT and EDIC at 30 Years: Advances and Contributions,Read how these trials have improved type 1 diabetes therapy and resulting outcomes in your patients.
December 2013 ,The British Journal of Dermatology,Interpreting Trials of Biologic Treatments for Psoriasis,How can one properly evaluate the many long-term studies of biologic treatments for psoriasis? This review provides tips on how to compare trial design and effectively analyze data.
December 2013 ,Skin Therapy Letter,Emerging Therapeutic Options in the Treatment of Psoriasis,"This review looks at several therapeutic classes of small molecules, both oral and topical, which are proving to be promising treatment options in psoriasis."
December 2013 ,Expert Review of Vaccines,Mobilizing and Evaluating Anticancer T Cells,What are the pitfalls and solutions for mobilizing and evaluating T cells in immunotherapy?
August 2013 ,Annals of Clinical Microbiology and Antimicrobials,New Antibiotics for Bad Bugs: Where Are We?,"Only one new antibiotic has been approved by the FDA since 2010, and few are in the pipeline -- yet new antibiotics are urgently needed. What's the current status of antibiotic development?"
November 2013 ,Current Opinion in Neurology,Pharmacological Prospects for Duchenne Muscular Dystrophy,Recent months have seen exciting developments regarding novel therapeutic agents for Duchenne muscular dystrophy. Where do we stand in finding an effective treatment?
November 2013 ,American Heart Journal,Shaping the Future of Acute Heart Failure Trials,Will a boost in heart failure research methods translate to better patient outcomes?
November 2013 ,Laboratory Investigation,Autophagy in EGFR-Independent EGFR-Mutant Lung Cancer,Could autophagy inhibitors alone or in combination with tyrosine kinase inhibitors be an effective approach for the treatment of EGFR-mutant lung cancers?
October 2013 ,The Hospitalist,Back to the Future,"This article profiles the winners of the Society of Hospital Medicine's annual Research, Innovations, and Clinical Vignettes scientific abstract and poster competition."
October 2013 ,Brain,Microtubule-Based Treatment of Disease the Nervous System,"In this review, the authors investigate the potential of microtubules as therapeutic targets for nerve injury, neurodegenerative diseases, and cancer of the nervous system."
October 2013 ,BMC Musculoskeletal Disorders,Disability and HRQoL in Patients Undergoing Spinal Fusion,How does spinal fusion surgery affect disability and health-related quality of life?
September 2013 ,Expert Review of Neurotherapeutics,Targeting the Trigeminocervical Complex in Migraine,This review explores the hypothesis that dysfunction of neural mechanisms that mediate trigeminovascular activation are at the root of migraine. Could this be a fruitful target for drug development?
October 2013 ,Future Neurology,Neuronal Adhesion and Synapse Organization After TBI,"In this article, the authors focus on the cellular and synaptic alterations that occur with traumatic brain injury. Could synaptic cell adhesion molecules be potential targets for future therapeutics?"
October 2013 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Using Electronic Surveys in Violence Research,"The sender of electronic surveys for violence research may influence response rates, a new study suggests."
October 2013 ,IRB: Ethics & Human Research,Research Participants' Expectations,Do people who are recruited for clinical research studies generally understand what they're participating in? This new article explores the issues.
October 2013 ,BMC Pulmonary Medicine,Psychometrics of CAMPHOR and SF-36 in Pulmonary Hypertension,Which tool should you choose for patients with pulmonary hypertension?
October 2013 ,Laboratory Investigation,"Patient-Derived Xenografts, the Cancer Stem Cell Paradigm, and Cancer Pathobiology in the 21st Century",Do we need a change in our basic approach to cancer pathobiology? This review calls for a new model of collaborative cancer research based on the cancer stem-cell paradigm.
October 2013 ,Personalized Medicine,Disclosure of Incidental Genomic Findings Involving Children,What are the consequences of disclosing genomic findings to children and their parents?
January 2014 ,AIDS,Highlights on HIV Eradication in 2013,"Almost 20 years after the introduction of HAART, we are still struggling to find a way to eradicate HIV. Is a cure for HIV infection achievable?"
January 2014 ,Alimentary Pharmacology & Therapeutics,Vitamin D and Inflammatory Bowel Diseases,"Are patients with a vitamin D deficiency at an increased risk for developing IBD, and does it also contribute to more severe disease? This new study examines the connection."
January 2014 ,The Pediatric Infectious Disease Journal,Effect of PCV Dosing Schedules on Prevention of Pneumonia,What is the optimum PCV dosing schedule for the prevention of pneumonia in children?
January 2014 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Maraviroc in HIV Patients: 5-Year Safety Data,Maraviroc is an approved antiretroviral drug with a unique mechanism of action. How safe is this therapy in treatment-experienced HIV+ patients?
January 2014 ,Current Opinion in Gastroenterology,Treatment of Ulcerative Colitis,"Since some medications, such as anti-TNF agents, work better than others in ulcerative colitis, how can clinicians best tailor treatments for their patients?"
January 2014 ,Current Orthopaedic Practice,Lumbar Disc Replacements and Motion Preservation Devices,What do we currently know about lumbar disc replacement and motion preservation devices?
January 2014 ,International Journal of Clinical Practice,Vortioxetine for Major Depressive Disorder,Vortioxetine is a recently approved antidepressant with a unique mechanism of action. This review summarizes available data regarding the efficacy and safety of vortioxetine for the treatment of MDD.
January 2014 ,HIV Medicine,CD4:CD8 Ratio and Markers of Age-Associated Disease in HIV,A low CD4:CD8 ratio despite at least 1 year of effective ART may be a marker of conditions associated with age-related disease.
January 2014 ,The Nation's Health,"As Hispanics Lag in Clinical Trials, Researchers Take Action","While there are a disproportionately high number of Hispanics living with chronic conditions in the US, many are not entering clinical trials. How can public health clinicians reach out and encourage them to partake?"
January 2014 ,Alimentary Pharmacology & Therapeutics,Comparative Effectiveness of HCV Protease Inhibitors,"This study examines the effectiveness of the 2 protease inhibitors, boceprevir and telaprevir. Is 1 preferred over the other?"
January 2014 ,Medicine and Science in Sports and Exercise,Artifacts in Plasma Volume Changes due to AHA-Derived HCT,How do changes in plasma osmolality affect the measurement of hematocrit?
January 2014 ,Menopause,Acupuncture and Herbs for Hot Flushes in Postmenopausal Women,What does the latest research tell us about the effectiveness of both acupuncture and Chinese herbs in the management of hot flushes in postmenopausal women?
January 2014 ,Annals of Clinical Microbiology and Antimicrobials,Antibacterial Activity of Nymphaea nouchali (Burm. f) Flower,Does the water lily flower Nymphaea nouchali have potential as a candidate for development of a novel broad spectrum antibacterial?
January 2014 ,Critical Care Medicine,Potentially Preventable Hospital Exposures and ARDS,Find out what specific hospital exposures impact the rate of acute respiratory distress syndrome development among at-risk patients.
January 2014 ,Journal of Medical Case Reports,CARE Guidelines for the Standardization of Case Reports,"This editorial serves as a brief introduction to the newly published CARE (CAse REport) guidelines, which aim to serve as a framework for the standardization of case reporting."
January 2014 ,Medicine and Science in Sports and Exercise,Exercise Training in Abdominal Aortic Aneurysm Disease,Learn more on the potential role exercise therapy can play in managing patients with early abdominal aortic aneurysm disease.
January 2014 ,Alimentary Pharmacology & Therapeutics,NASH: A Case for Personalized Treatment,"As clinicians begin to better understand the pathophysiology of NASH, what future treatment strategies lie ahead for them to manage the disease in their patients?"
January 2014 ,Current Opinion in Allergy and Clinical Immunology,Sublingual Immunotherapy in Clinical Trials and Real Life,"Sublingual immunotherapy is effective in allergic rhinitis and asthma, but apart from its efficacy, safety is crucial since it's usually self-administered. . ."
January 2014 ,Nanomedicine,Strategies for Improving Mucosal Drug Delivery,"Transmucosal drug delivery is a promising approach, as it is easy to administer, nonpainful, and enhances patient compliance. What recent progress has been made in drug delivery for mucosal surfaces?"
January 2014 ,International Journal of Clinical Practice,Vortioxetine for Treatment of Generalised Anxiety Disorder,Is the newly approved novel antidepressant vortioxetine useful in the treatment of generalized anxiety disorder?
February 2014 ,Future Oncology,Metabolism and Transport of Tamoxifen,Learn more about the association between CYP2D6 inhibition and tamoxifen effectiveness.
February 2014 ,The Pediatric Infectious Disease Journal,Effect of PCV Dosing Schedules on Pneumococcal Disease,How much effect do PCV dosing schedules have on pneumococcal disease in infants?
February 2014 ,AIDS,Non-AIDS-Related Mortality Among HIV-Infected Individuals,This study compares non-AIDS related mortality of HIV+ individuals who started HAART at different CD4 levels with mortality of individuals not infected with HIV.
February 2014 ,Journal of Perinatology : Official Journal of the California Perinatal Association,Work of Breathing in Infants With Respiratory Insufficiency,This study compares infants' work of breathing while receiving different settings of nasal CPAP and high flow oxygen via nasal cannula.
February 2014 ,Current Opinion in Allergy and Clinical Immunology,Single vs Multiple Antigens in Allergic Rhinitis Immunotherapy,Controversial aspects of single vs multiallergen allergen immunotherapy are reviewed.
February 2014 ,Clinical Endocrinology,TRAIL Concentration and Diabetic Therapy,Is this protective marker of endothelial function increased after initiation of antidiabetes agents?
January 2014 ,Current Opinion in Pulmonary Medicine,An Update on Allergen Immunotherapy and Asthma,Learn more about the effect of allergen-specific immunotherapy on asthma.
January 2014 ,Morbidity & Mortality Weekly Report,Evidence-Based Injury Prevention,How can public health clinicians work together to educate the public about the ways in which to prevent injuries of all types? This new report looks at strategies.
January 2014 ,American Heart Journal,Trends Among Older Patients With Non-STEMI,Learn about evidence-based therapy use and short- and long-term mortality over time among older patients with non-STEMI.
January 2014 ,Europace,Atrial Fibrillation Management After 2010 ESC AF Guidelines,Did the management of AF patients in 2012 adapt to guideline recommendations or go rogue?
January 2014 ,Journal of Gastroenterology and Hepatology,Effect of Probiotics on Irritable Bowel Syndrome,Do probiotics help IBS patients with the management of the various symptoms associated with the disease?
January 2014 ,Alimentary Pharmacology & Therapeutics,Managing Chronic HCV in Patients Unable to Take Antivirals,"Besides standard treatments, such as interferon-based antiviral therapy, what are some of the other treatment strategies that can be employed to manage chronic hepatitis C?"
January 2014 ,Journal of Viral Hepatitis,"HCV and Lipid Metabolism, Hepatic Steatosis, and NAFLD",Is there a role for lipid lowering therapy in combination with PEG/RBV in the treatment of hepatitis C and other liver diseases?
January 2014 ,Infection Control and Hospital Epidemiology,Mortality of MRSA USA300 vs. Non-USA300 Invasive Infections,Are MRSA USA300 infections associated with higher mortality than non-USA300 invasive infections?
January 2014 ,Menopause,Effects of Low-fat Diet on Serum Lipids in Women,What effect does a low-fat diet have on lipids in both premenopausal and postmenopausal women? This new study looks at the numbers.
January 2014 ,Journal of Cardiovascular Electrophysiology,Cryoballoon vs RF Ablation in Paroxysmal Atrial Fibrillation,Which ablation method has the best acute success and lowest overall complication rate for treating paroxysmal atrial fibrillation?
January 2014 ,BMC Musculoskeletal Disorders,Characteristics for Describing Patients With Knee OA,A survey of clinical experts identifies the baseline characteristics to appropriately describe patients with knee OA.
January 2014 ,Nanomedicine,Shaping Cancer Nanomedicine: The Effect of Particle Shape,How does a nanoparticle's shape affect its rate of tumor penetration and therapeutic efficacy in cancer drug delivery?
January 2014 ,Future Neurology,Optimizing Mouse Models of Neurodegenerative Disorders,"This review takes a look at the history of model development for neurodegenerative diseases. What has been learned which may improve the design, development and use of mouse models?"
January 2014 ,Clinical Endocrinology,Level of Glycemic Control and Associated Factors in T2DM,Hit or miss? Are patients achieving goals for type 2 diabetes treatment?
February 2014 ,The British Journal of Dermatology,Radiotherapy for Lentigo Maligna,The authors present recommendations for radiotherapy of lentigo maligna based on their experience from a multidisciplinary lentigo maligna clinic.
February 2014 ,Menopause,Women's Health Initiative Clinical Trials,Could calcium and vitamin D supplementation help to prevent fractures in women who are already on hormone therapy? This new study investigates.
February 2014 ,American Journal of Transplantation,Costs Among Patients Awaiting Liver Transplantation,What's the economic burden of liver disease -- in the pre-transplant phase?
February 2014 ,HIV Medicine,HIV Guidelines and Treatment Outcomes,How closely do physicians adhere to national guidelines for HIV treatment and how does this affect patient outcomes?
February 2014 ,American Heart Journal,Absolute Survival After CRT According to Baseline QRS,Does baseline QRS duration relate to absolute survival after cardiac resynchronization therapy?
" Open Access Journal of Plastic Surgery, February 2014 ",ePlasty,Use of Bacteria- and Fungus-binding Mesh in NPWT,Pathogen-binding mesh may be a viable alternative to foam and gauze as a wound filler in NPWT.
February 2014 ,American Journal of Clinical Dermatology,Treatment of Hereditary Epidermolysis Bullosa,"While there is currently no effective therapy or cure for epidermolysis bullosa, a number of recent advances have been made that may bring new hope to sufferers of this disfiguring disease."
February 2014 ,Future Microbiology,Leprosy as a Model of Immunity,"In this review, the authors present M. leprae as a model for investigating the role of the human immune system in host defense and susceptibility to infection."
February 2014 ,Pediatric Critical Care Medicine,Effort of Breathing in Children on High-Flow Nasal Cannula,Find out about an objective measure of breathing effort to evaluate high-flow humidified nasal cannula use in critically ill children.
February 2014 ,Spine,Changes in Spinal Cord Compression by Cervical OPLL,"Using kinematic CT myelography images, the authors assess the dynamic factors in patients with cervical myelopathy due to OPLL."
February 2014 ,Brain,Diagnosis of Guillain-Barre Syndrome: The Brighton Criteria,"In this article, the authors describe in detail the key diagnostic features required to meet the recently proposed Brighton criteria for diagnosis of Guillain-Barre syndrome."
February 2014 ,Clinical Endocrinology,Association of Paternal Age on Stature and Lipids in Kids,What physical and metabolic characteristics do children have who are born to men over 35?
February 2014 ,Annals of Family Medicine,Expectations of Antibiotics for Upper RT Infections,This qualitative study aimed to explore how and why family physicians elicit and address patients' or parent's expectations for antibiotics for upper respiratory tract infection.
February 2014 ,Neurosurgical Focus,Therapeutic Options in Asymptomatic Carotid Artery Stenosis,This review looks at the evidence for -- and controversy surrounding -- both medical and surgical approaches to management of asymptomatic carotid artery disease.
February 2014 ,Eye,Outcomes of Corneal Collagen Crosslinking Treatment,"How successful is corneal crosslinking treatment in patients with progressive keratoconus, and what are some of the factors that could influence outcomes?"
February 2014 ,The British Journal of Dermatology,Comparison of Worldwide Melanoma Guidelines,This review looks at the evidence and available literature for the management of melanoma worldwide. How do guidelines differ among the major expert groups?
February 2014 ,American Heart Journal,Cilostazol Use Plus Dual Antiplatelet After Biolimus-Eluting Stent,Does 3 months of cilostazol use improve 1-yr clinical outcome above dual antiplatelet therapy alone?
February 2014 ,Annals of Oncology,Increased Cancer Risk From Commonly Used Medications,Are current medication and cancer-link claims valid?
February 2014 ,Laboratory Investigation,Programmed Death Ligand-1 Expression in NSCLC,This paper describes a reproducible method of measuring programmed death ligand-1 protein and mRNA and demonstrates the prognostic relevance of these biomarkers in non-small cell lung cancer.
February 2014 ,HIV Medicine,Effect of ART Initiation Time on HIV/TB Coinfection Outcomes,This study evaluates whether the interval between the initiation of ART and the initiation of anti-tuberculosis treatment in HIV/tuberculosis-coinfected patients has an effect on clinical outcomes.
February 2014 ,Journal of the American Board of Family Medicine,Effects of Ginger for Nausea and Vomiting in Early Pregnancy,Is ginger safe and effective for the relief of morning sickness?
February 2014 ,Clinical Endocrinology,Is Hyperthyroidism Associated With Cognitive Dysfunction?,Does hyperthyroidism adversely affect cognition? What does the research find?
February 2014 ,Spine,Utilization of Cervical Artificial Disc Replacement vs ACDF,How prevalent is the use of cervical disc arthroplasty compared with ACDF? This study takes a look at the utilization rates after FDA approval of CDA devices.
February 2014 ,Pediatric Critical Care Medicine,Acute Respiratory Distress Syndrome in Children,"Surfactant therapy has become a routine for neonatal respiratory care and already proved to reduce morbidity and mortality in neonatal respiratory distress syndrome. Should it be used in children, too?"
February 2014 ,Cancer Control: Journal of the Moffitt Cancer Center,Lung Cancer Screening,"What's an acceptable risk in screening for lung cancer, the leading cause of cancer death in the US?"
February 2014 ,The British Journal of Dermatology,Bimodal Immune Activation in Psoriasis,"Is psoriasis a complex of related diseases, as sometimes proposed, or a single entity with a bimodal immunopathology?"
February 2014 ,American Heart Journal,2 Types of Epoprostenol for Pulmonary Arterial Hypertension,Is this novel and stable IV epoprostenol formulation also well tolerated by patients with pulmonary arterial hypertension?
February 2014 ,Journal of the American College of Cardiology,Rosuvastatin for Contrast-Induced Nephropathy in ACS,Patients with acute coronary syndrome are at high risk for contrast induced acute kidney injury. Find out more about the role of statin pre-treatment in preventing renal damage.
February 2014 ,HIV Medicine,Telaprevir-Based Triple Therapy for HIV/HCV Coinfection,This study compares the effectiveness of telaprevir-based triple therapy for hepatitis C in patients with and without HIV coinfection.
February 2014 ,BMC Dermatology,Comparison of Publication Trends in Dermatology in Asia,"This study compared the characteristics of publications over ten year period in dermatology in mainland China, South Korea and Japan. Are publications increasing in quantity and quality?"
February 2014 ,Current Orthopaedic Practice,Artificial Cervical Disc Arthroplasty vs ACDF,Is artificial cervical disc arthroplasty a safe alternative to ACDF? This review explores the issue.
February 2014 ,Journal of Pediatric Health Care,"Postpartum Depression, Infant Feeding and Weight",Does postpartum depression affect infant feeding and weight gain?
February 2014 ,Journal of the American Board of Family Medicine,Aspirin for Prevention of Cardiovascular Events,"Recent evidence has indicated that the use of aspirin for primary prevention of cardiovascular events is ineffective, and potentially harmful. Are physicians heeding new guidelines?"
February 2014 ,Spine,Adjacent Segment Disease After ACDF,A new study compares the long-term outcomes of patients who underwent repeat ACDF procedures due to adjacent segment disease. What are the results?
February 2014 ,Alimentary Pharmacology & Therapeutics,Controversies in Cholestatic Diseases,Are clinicians conflicted on the best management strategies for both primary biliary cirrhosis and primary sclerosing cholangitis? This new study explores the best treatment options as well as the current controversies.
February 2014 ,The Journal of Emergency Medicine,Can Plain Radiographs Exclude Cervical Spine Injuries?,Plain radiographs may not be the best option for detecting cervical spine injuries in otherwise low-risk patients.
February 2014 ,International Journal of Impotence Research,Link Between Erectile Function and Sexual Self-Confidence,How can erectile function impact sexual confidence? This study investigates the issue in men treated with the PDE-5 inhibitor tadalafil.
February 2014 ,Infection Control and Hospital Epidemiology,Healthcare Personnel Attire in Non-Operating-Room Settings,Is your work attire spreading infection? This article examines the relationship between healthcare personnel attire and healthcare associated infection.
February 2014 ,Journal of Viral Hepatitis,Chronic Hepatitis E: A Review of the Literature,Chronic hepatitis E infection -- from the microbiological aspect through overall disease management -- is reviewed.
February 2014 ,Human Reproduction,Severe Depressive Symptoms and Infertility-related Distress,How common is it for patients and their partners undergoing infertility treatments to also experience severe depression?
March 2014 ,Annals of Clinical Microbiology and Antimicrobials,Antifungal Activity of Farnesyltransferase Inhibitors,"This study investigated the antifungal potential of mamumycin A, a farnesyltransferase inhibitor, against Aspergillus and Candida."
March 2014 ,The British Journal of Dermatology,Antidrug Antibodies in Psoriasis: A Systematic Review,This review examines the prevalence and impact of antidrug antibodies against biological agents used in the treatment of psoriasis. Can their formation be prevented?
March 2014 ,Clinical Endocrinology,Relative Risk for Goiter in Euthyroid Patients With T2DM,Does insulin or metformin increase the risk of goiter in patients with diabetes?
March 2014 ,Alimentary Pharmacology & Therapeutics,Linaclotide for the Management of IBS With Constipation,Are there any particularly effective drugs on the market to treat constipation that presents in patients with IBS? This new study describes.
March 2014 ,Clinical Lipidology,Treatment of Homozygous Familial Hypercholesterolemia,Find out more about this relatively rare disease with reduced receptor-mediated catabolism of LDL causing high plasma LDL cholesterol and premature coronary artery disease.
March 2014 ,American Journal of Public Health,Rural-Urban Differences in Nonmedical Prescription Opioid Use,"Why is nonmedical prescription opioid misuse more prevalent in rural areas than in urban areas, and why is it on the increase?"
March 2014 ,Personalized Medicine,Antidepressant-Induced Suicidality and Pharmacogenetics,Will pharmacogenomics help determine who is least likely to have treatment-associated risks with SSRIs?
March 2014 ,BMC Musculoskeletal Disorders,Effectiveness of Abatacept for RA in Europe and Canada,IV abatacept may be a safe and effective therapeutic option for patients with moderate-to-severe rheumatoid arthritis.
March 2014 ,Journal of the American Board of Family Medicine,MALAdaptive: Do We Avoid Metformin Unnecessarily?,"The use of metformin is often avoided in diabetic patients due to the fear of lactic acidosis, a potentially serious adverse effect. Is this fear justified?"
February 2014 ,Clinical Journal of Sport Medicine,PRP in the Management of Articular Cartilage Pathology,How beneficial are autologous PRP injections in treating osteochondral pathologies?
February 2014 ,Current Opinion in Psychiatry,Differentiating Bipolar II Disorder From Borderline PD,"While differentiating bipolar I disorder from borderline personality disorder is relatively straightforward, diagnosing bipolar II is more challenging. What clinical differences can help pin it down?"
February 2014 ,American Journal of Transplantation,Diagnosis and Management of Antibody-Mediated Rejection,"Learn more about the spectrum of antibody-mediated rejection after kidney transplantation, including its pathogenesis, risk factors, and phenotypes."
February 2014 ,Future Oncology,"Nintedanib, Afatinib and Sequential Combination in CRPC",Is this combo's anti-tumor-activity enough to impact advanced castration-resistant prostate cancer?
February 2014 ,Kidney International,Summary of KDIGO 2012 CKD Guideline,"What do the latest clinical guidelines say about the pathophysiology of chronic kidney disease, and the best ways to manage and treat it?"
February 2014 ,American Heart Journal,Balloon Aortic Valvuloplasty in the Era of TAVI,What's the long-view on outcomes in patients treated with balloon aortic valvuloplasty -- in the period since TAVR was developed?
February 2014 ,Journal of the American College of Cardiology,Heart Failure With Preserved Ejection Fraction,Find out more about coexisting angina and heart failure. How does comorbidity-coexistence impact patient outcomes?
February 2014 ,Journal of Gastroenterology and Hepatology,Folate Intake and the Risk of Upper Gastrointestinal Cancers,What does the latest science tell us about the possible connection between folate intake and the risk for developing upper gastrointestinal cancer?
February 2014 ,Journal of Pediatric Psychology,Becoming a Pediatric Psychologist: A Winding Road,"The author describes her career path as a pediatric psychologist from the 1970s to the present. How has the field evolved over the last 40 years, and what does the future hold?"
February 2014 ,European Heart Journal,Follow-up of Remotely Monitored ICD Recipients,"For patients with prophylactic ICD placement, automatic daily remote monitoring may reduce the burden of office visit follow-ups."
February 2014 ,BMC Clinical Pathology,Should Prophylactic Thrombolysis Be Routine With a CVC?,"Catheter-related thrombosis is known to be a frequent complication of central venous lines, and may introduce Candida infection. Should prophylactic thrombolysis be routine?"
March 2014 ,Pharmacogenomics,Pharmacogenetics-Based Warfarin Dosing in Children,This review describes the two main types of pharmacogenetic-based warfarin dose prediction models and their applicability to children. What are their respective advantages and limitations?
March 2014 ,Annals of Oncology,Short-term Psychotherapy for Depressed Breast Cancer Patients,Find out more about psychodynamic therapy in non-metastatic breast cancer patients with depression.
March 2014 ,Alimentary Pharmacology & Therapeutics,The Impact of Hepatitis C Burden,"How much of a burden does hepatitis C place on the patient, on the healthcare system, and on society in general?"
March 2014 ,Nursing Economics,The Impact of Research on Staffing,Learn more about a keen vision for future directions in staffing.
March 2014 ,BMC Family Practice,Lower Urinary Tract Symptoms in Men and CVD,This longitudinal study investigated the relationship between lower urinary tract symptoms in men and cardiovascular diseases. Is there an association?
March 2014 ,AIDS,"Cancers in HIV/AIDS: Epidemiology, Therapeutic Challenges",This article reviews the epidemiology and etiology of cancers seen in HIV/AIDS.
March 2014 ,Alimentary Pharmacology & Therapeutics,Inflammatory Bowel Disease in the Elderly,"Does IBD present uniquely in elderly patients, and does it require a different treatment strategy?"
March 2014 ,Current Orthopaedic Practice,The Progression of Total Knee Arthroplasty From 1993-2013,This review takes a look at the recent advances and emerging technologies in total knee arthroplasty.
March 2014 ,BMC Musculoskeletal Disorders,Non-displaced Distal Radial Fractures in Adult Patients,"In patients with non-displaced distal radial fractures, can cast immobilization be safely reduced to three weeks?"
March 2014 ,Critical Care Medicine,Two Decades of Mortality Trends in Severe Sepsis,Compare time trends in severe sepsis mortality using both clinical trial data and administrative data -- to find out if we're saving more lives today.
March 2014 ,Breast Cancer Research,BreastMark: Transcriptomic Datasets and Breast Cancer Outcome,Find out more about this powerful tool for examining miRNA prognostic markers in breast cancer.
March 2014 ,Menopause,Venous Thromboembolism Risk Among Postmenopausal Women,"Does the age at which a woman reaches menopause, as well as her reproductive history, put her at an increased risk for venous thromboembolism? This new article takes a look at the connection."
March 2014 ,European Heart Journal,Atrial Fibrillation Treated With Vitamin K Antagonism,How does rivaroxaban compare with warfarin for reductions in cardiovascular events -- in patients with atrial fibrillation and a prior MI?
March 2014 ,Journal of Gastroenterology and Hepatology,Personalized Chronic Hepatitis C Treatment,Could IL28B genotyping move us closer to personalized hepatitis C treatment in the forthcoming era of direct-acting antivirals?
March 2014 ,Alimentary Pharmacology & Therapeutics,Sofosbuvir in the Treatment of Chronic Hepatitis C,What's the efficacy and safety of sofosbuvir-containing regimens in the treatment of chronic hepatitis C?
March 2014 ,Journal of Cardiovascular Electrophysiology,Circumferential Pulmonary Vein Isolation in Paroxysmal AF,"Find out more about rapid firing in pulmonary veins, a leading cause of paroxysmal atrial fibrillation. . ."
March 2014 ,Nanomedicine,Nanotoxicity: An Obstacle to siRNA-Based Nanomedicine,"siRNAs have immense therapeutic potential for the treatment of various gene-related diseases, but the safety of the nanocarriers necessary for their delivery is a challenge to be overcome."
March 2014 ,International Journal of Clinical Rheumatology,The Future of Treatment for Psoriatic Arthritis,An increased knowledge of psoriatic disease has stimulated the development of targeted biologic medications.
March 2014 ,Current Opinion in Infectious Diseases,Global Resistance of Neisseria gonorrhoeae,The control of gonorrhoea is failing at the global level. We are in desperate need of novel antimicrobial agents and a gonococcal vaccine.
March 2014 ,BMC Psychiatry,Cost-effectiveness of Asenapine for Bipolar Disorder,"Asenapine, a tetracyclic antipsychotic, has shown a comparable efficacy profile to other atypical antipsychotics for treatment of bipolar disorder. How does it compare in cost?"
April 2014 ,HIV Medicine,ART and the Risk of Clinical Depression in HIV+ Patients,How does ART affect risk for depression in HIV+ patients?
March 2014 ,American Heart Journal,Patterns of Medical Management Strategy in NSTEMI and CAD,Is there a standard threshold for the use of revascularization in NSTEMI patients with 3VD/LMD?
March 2014 ,Neurosurgical Focus,Near-Complete Resection of Brain Tumors Using Tumor Paint,"The authors describe a proof-of-concept intraoperative near-infrared imaging system to detect a novel tumor ligand with a high affinity for glioma, potentially enabling near-complete tumor removal."
March 2014 ,Nephrology Dialysis Transplantation,Iron Toxicity: Relevance for Dialysis Patients,Could intravenous iron supplementation put hemodialysis patients at risk for iron toxicity? This new study explores the potential safety concerns.
March 2014 ,Menopause,Hormone Therapy and Risk of Cardiovascular Events in Women,"Does hormone therapy raise the risk of cardiovascular events in women, and what role does dosage and route of delivery play in this possible risk?"
March 2014 ,Future Oncology,Sentinel Lymph Node Biopsy in Melanoma,Get current data regarding patient selection for SLNB in melanoma and learn about areas where the procedure remains controversial. . .
March 2014 ,BMC Pulmonary Medicine,A COPD Biopsy Trial With Roflumilast,How well does roflumilast reduce the characteristic inflammation of COPD in patients with moderate-to-severe COPD?
March 2014 ,Current Opinion in Neurology,TBS to Promote Functional Recovery After Stroke,"Noninvasive brain stimulation shows great promise in enhancing post-stroke recovery, but many questions must be answered before it can be effectively targeted and tailored to the individual patient."
March 2014 ,Journal of the American College of Cardiology,"ACE Inhibitor, ARB, and Mortality in Chronic Kidney Disease",What's the connection between angiotensin-converting enzyme inhibitor/angiotensin receptor blocker use and mortality in patients with chronic kidney disease?
March 2014 ,Journal of Cardiovascular Electrophysiology,Real-time Contact Force Sensing for PVI in Paroxysmal AF,Does real-time contact force sensing 'reel in' the number of redo-interventions to maintain sinus rhythm?
March 2014 ,International Journal of Clinical Practice,Treatment Outcomes for Benign Prostatic Obstruction,This study compared the benefits of surgical vs. medical therapy for treatment of lower urinary tract symptoms due to BPH.
March 2014 ,International Journal of Clinical Rheumatology,Recent Advances in the Treatment of SLE,This article reviews the current and future treatment options for SLE.
March 2014 ,Alimentary Pharmacology & Therapeutics,Anti-adhesion Therapies for Inflammatory Bowel Disease,"How effective are new monoclonal antibodies in the treatment of IBD, and how do they compare with immunosuppressive agents prescribed in the past?"
March 2014 ,Current Opinion in Infectious Diseases,Current Thinking on Genital Herpes,Recent advances in our understanding of genital herpes may help guide new strategies for disease prevention and control.
March 2014 ,Diabetes Care,Antibiotics vs Surgery for Diabetic Foot Osteomyelitis,Do all patients with diabetic foot osteomyelitis require surgical intervention?
March 2014 ,Cardiovascular Diabetology,Residual Macrovascular Risk in 2013: What Have We Learned?,"Are PPAR agonists, CETP inhibitors, and PCSK9 inhibitors the future of cardiometabolic risk reduction?"
March 2014 ,American Heart Journal,Hemorrhagic Risk and Bivalirudin vs UFH in PCI,"What's the impact of bivalirudin compared with UFH on the rates of mortality, myocardial infarction, and major bleeding?"
March 2014 ,Pediatric Pharmacotherapy,Micafungin Use in the Treatment of Pediatric Fungal Infections,Is Micafungin an effective treatment for Candida species infections in children?
March 2014 ,The Pediatric Infectious Disease Journal,Afebrile Very Young Infants With UTI and Risk for Bacteremia,Is fever a predictor for bacteremia in very young infants with UTIs?
March 2014 ,Personalized Medicine,Whole-Exome Sequencing in Pediatric Endocrinology,Read how next-generation sequencing can help diagnose growth disorders in children.
April 2014 ,Diabetes,Complications & Mortality in People With T2DM & CVD or Risks,Does C-reactive protein predict mortality risk in patients with diabetes and heart disease?
April 2014 ,Clinical Journal of Oncology Nursing,Triple-Negative Breast Cancer: What Is Known About It?,This article provides suggestions for nurses as they guide women who are experiencing an atypical breast cancer diagnosis with an uncertain prognosis and limited treatment options.
April 2014 ,Journal of the National Cancer Institute,Chemotherapy Usage Patterns in Metastatic Colorectal Cancer,Find out what treatment trends are emerging in metastatic colorectal cancer.
March 2014 ,AccessMedicine from McGraw-Hill,Trametinib: An Oral MEK Inhibitor for Metastatic Melanoma,"The FDA recently approved trametinib, a first-in-class, oral MEK inhibitor for patients with unresectable or metastatic melanoma with BRAF V600/K mutations. What are the implications?"
April 2014 ,European Heart Journal,The Year in Cardiology 2013: Heart Failure,Is there a new dawn of hope for acute heart failure therapy?
April 2014 ,Spine,Outcomes After Microdecompression of Spinal Stenosis,This new study takes a look at the postoperative outcome 5 years after interspinous microdecompression for lumbar spinal stenosis. What are the results?
April 2014 ,Current Opinion in Allergy and Clinical Immunology,Early Weight Gain Asthma and Atopy in Children,Learn more about the comorbid connection between weight gain and asthma in infancy.
April 2014 ,Journal of Perinatology : Official Journal of the California Perinatal Association,Preterm Infant Outcomes Following Intracranial Hemorrhage,What variables could predict outcomes for extremely preterm infants with intracranial hemorrhage?
April 2014 ,BMC Musculoskeletal Disorders,Trunk Muscle Activation During Abdominal Hollowing In CLBP,"In this study, the muscle activation patterns of chronic low back pain patients during the abdominal hollowing maneuver are examined."
April 2014 ,BMC Neurology,Chronic Inflammatory Demyelinating Polyradiculoneuropathy,Chronic inflammatory demyelinating polyradiculoneuropathy is a rare acquired immune-mediated peripheral neuropathy. Are there any effective therapies?
April 2014 ,BMC Pulmonary Medicine,Exhaled Breath Condensate in Idiopathic Pulmonary Fibrosis,Is there such a thing as biomarker-breath -- in patients with pulmonary fibrosis?
April 2014 ,Endocrine Practice,Insulin Treatment Persistence Among Patients With T2DM,What patient factors influence adherence to insulin therapy?
April 2014 ,Clinical Gastroenterology and Hepatology,Rational Helicobacter pylori Therapy,What is the current recommended regimen for the treatment of H. pylori disease?
April 2014 ,International Ophthalmology Clinics,Ocriplasmin and Vitreoretinal Interface Disorders,Learn about the safety and efficacy of intravitreal ocriplasmin for vitreomacular adhesion.
April 2014 ,Clinical Endocrinology,Exenatide's Effect on Beta-cell Function in New Onset T2DM,Does daily GLP-1 receptor agonist use improve beta-cell function?
April 2014 ,Alimentary Pharmacology & Therapeutics,Tenofovir vs Entecavir for Viral Suppression in Chronic HBV,"Is there a difference between 2 antivirals, tenofovir and entecavir, in the treatment of HBeAg-positive chronic hepatitis B?"
April 2014 ,Annals of Oncology,Adjuvant Radiotherapy Impact in Primary Breast Cancer,Just how vital is guideline-adherent adjuvant radiotherapy -- for improving survival in primary breast cancer?
April 2014 ,Pacing and Clinical Electrophysiology,Interference Between Medical and Field Devices Is Real,Are numerous telecommunication systems and our lack of knowledge creating an electromagnetic mine-field?
April 2014 ,European Heart Journal,Haemodynamic Effects of Serelaxin in Acute Heart Failure,Do the hemodynamic effects of serelaxin provide plausible mechanistic support for improvement in signs and symptoms of acute heart failure?
April 2014 ,BMC Psychiatry,Reducing Symptoms of MDD Through Systematic Training,This study evaluates the impact on depressive symptoms of a group-based training which targets general emotion regulation skills.
April 2014 ,Nephrology Dialysis Transplantation,Hypertension in Hemodialysis Patients,Is atenolol-based antihypertensive therapy superior to lisinopril-based therapy in preventing cardiovascular morbidity in hemodialysis patients?
April 2014 ,Clinical Lipidology,"Adipose Tissue, Inflammation and Atherosclerosis","Extensive research in recent decades has revealed manifold metabolic functions of adipose tissue, beyond its purpose as a simple storage organ for fatty acids."
April 2014 ,Current Opinion in Nephrology and Hypertension,Are Diuretics Harmful in the Management of AKI?,This new study explores the safety of diuretics in the treatment of acute kidney injury. What does the latest research reveal?
April 2014 ,European Heart Journal,The Year in Cardiology 2013: Arrhythmias,Don't miss this current review of top arrhythmia-related happenings from a most electric year.
April 2014 ,Pediatric Critical Care Medicine,Analgesia-Sedation in PICU and Neurological Outcome,Does the use of opioids during PICU admission correlate with long-term adverse neuropsychological outcomes in meningococcal septic shock survivors?
April 2014 ,Clinical Endocrinology,Response in Cushing's Syndrome Treated With Mifepristone ,What are strong drivers of response to mifepristone therapy in patients with Cushing disease?
April 2014 ,Annals of Surgery,Surgical Skills Transfer After Simulation-Based Training,Do skills acquired through simulation-based training transfer to the operating room?
April 2014 ,Eye,Visual Outcomes in DME Treated With Ranibizumab,Why do some DME patients continue to have poor vision after ranibizumab therapy? This new study examines the issue.
April 2014 ,Europace,Current Periprocedural Management of Atrial Fibrillation Ablation,Are your practice patterns for atrial fibrillation ablation patient-prep up-to-speed?
April 2014 ,European Heart Journal,Catheter Ablation vs Antiarrhythmic Agent for Persistent AF,Compare the effectiveness of catheter ablation vs antiarrhythmic drug therapy in treating persistent atrial fibrillation.
April 2014 ,Diabetes Care,Microalbuminuria as a Risk Predictor in Diabetes,Do you screen your patients with cardiovascular disease for microalbuminuria? This research suggests that you should.
April 2014 ,Cardiovascular Diabetology,Do Incretins Improve Endothelial Function?,Read how GLP-1 agonists and DPP-4 inhibitors may protect the cardiovascular system.
April 2014 ,BMC Musculoskeletal Disorders,The Impact of Low Back Pain on People's Lives,It is important for clinicians to consider the social factors associated with this condition and the ways it can influence quality of life.
April 2014 ,BMC Psychiatry,When Eating Healthy Is Not Healthy: Orthorexia Nervosa,Is orthorexia nervosa -- an condition in which a person is excessively preoccupied and obsessed with eating only healthy food -- a valid subtype of eating disorder?
April 2014 ,Cancer Control: Journal of the Moffitt Cancer Center,Therapies for Early-stage Lung Cancer,"Even with aggressive surgical treatment, relapse rates remain high for patients with resectable non-small-cell lung cancer. . ."
April 2014 ,Pediatric Pharmacotherapy,Everolimus Use in Children With Tuberous Sclerosis Complex,Everolimus has been found to be a valuable tool in the management of children with tuberous sclerosis complex.
April 2014 ,AIDS,ART Use and Kidney Function: Clinical Practice Implications,What effect does antiretroviral therapy have on the kidney?
April 2014 ,Neurosurgical Focus,Applications of Fluorescent Technology in Neurosurgery,"There's been tremendous excitement regarding the use of targeted fluorescent agents in neurosurgery. But as this commentary suggests, near-infrared technology also has its challenges."
April 2014 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Impact of HBV/HCV on Hospitalization in HIV+ Persons,Does hepatitis coinfection increase health care utilization among persons living with HIV?
April 2014 ,American Journal of Public Health,The State of Transgender Health Care,"What are some of the specific healthcare needs of the transgendered community, and how can clinicians work together to ensure that the needs are met?"
April 2014 ,Current Opinion in Rheumatology,Antineutrophil Cytoplasm Antibody-Associated Vasculitis,What new therapies are coming down the pipeline for the treatment of antibody-associated vasculitis?
April 2014 ,European Heart Journal,Family History of Premature Cardiovascular Disease,Does inclusion of family history of CVD improve prognostics?
April 2014 ,BMC Musculoskeletal Disorders,Meniscus Body Position and Its Change in Asymptomatic Adults,Learn more about the meniscal position in asymptomatic knees. How does it change over time?
April 2014 ,Journal of Viral Hepatitis,Resistance and Response in HCV Genotype 1 Subtypes,How do response rates and resistance patterns for approved and investigational direct-acting antivirals differ between the 2 major HCV genotype 1 subtypes?
April 2014 ,Social Cognitive and Affective Neuroscience,Emotion Processing Efficiency in Healthy Males vs. Females,Do females and males process emotions using different neural pathways? This neuroimaging study compared processing of facial emotions in male and female subjects.
April 2014 ,Journal of the American College of Cardiology,STEMI Treated by Radial or Femoral Approach,"Radial access may have better outcomes than femoral, operator experience can still tips the scales."
March 2014 ,Spine,In-Hospital Outcomes in Cervical Spine Surgery,Find out how cervical spine surgery is trending and how it impacts patient outcomes.
April 2014 ,Rheumatology,Safety Issues With Bisphosphonate Therapy for Osteoporosis,"Studies have shown that bisphosphonates improve BMD and reduce fracture risk, but various safety issues were not addressed."
April 2014 ,Gastroenterology,Cancer Risk With Adalimumab in Crohn's Disease,"Are patients with Crohn's disease taking anti-TNF agents, either as a monotherapy or in combination with other drugs, at an increased risk for developing malignancies? This new study investigates."
April 2014 ,Alimentary Pharmacology & Therapeutics,HCV Genotype 3 -- The New Treatment Challenge,"Hepatitis C genotype 3 can be a difficult disease to treat. What options, besides antivirals and pegylated interferon, are available to clinicians?"
April 2014 ,BMC Musculoskeletal Disorders,Screening of the Spine in Adolescents,Are these clinical tests reliable tools for the screening of child and adolescent spines?
April 2014 ,HIV Medicine,Atazanavir Resistance With Unplanned Treatment Interruptions,This study examines the emergence of resistance to boosted PI-containing ART after multiple unplanned treatment interruptions.
April 2014 ,BMC Pulmonary Medicine,Determinants of Arterial Stiffness in COPD,What's the recipe for prediction of arterial stiffness in patients with COPD?
April 2014 ,Critical Care Medicine,Multibiomarker Outcome Risk Model for Septic Shock,Learn more about a validated risk stratification tool that reliably estimates the probability of mortality in adults with septic shock.
April 2014 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,Task Shifting for the Delivery of Pediatric ART,Task shifting is now a broadly practiced approach to improve access to ART in HIV+ adults. Could this approach benefit pediatric patients?
April 2014 ,International Journal of Clinical Practice,Lone Atrial Fibrillation -- An Overview,The term 'lone' atrial fibrillation has been used to describe AF in younger individuals without any apparent cardiac disease. What are its clinical implications?
April 2014 ,Seminars in Respiratory and Critical Care Medicine,Biomarkers in CTD-Associated Interstitial Lung Disease,Learn more about major biomarkers with respect to their diagnostic and prognostic value in connective tissue disease-associated interstitial lung disease (CTD-ILD).
April 2014 ,Skin Therapy Letter,Steroid-Sparing Properties of Emollients in Dermatology,This review looks at a variety of alternatives to steroids with similar anti-inflammatory and barrier repair properties for use in the treatment of inflammatory dermatoses.
April 2014 ,American Journal of Transplantation,Pain Identifies Squamous Cell Carcinoma in Organ Transplant,Learn to define clinically meaningful warning signals predicting the invasive cutaneous squamous cell carcinomas -- in transplant recipients.
April 2014 ,Future Oncology,Molecular Imaging in Recurrent Prostate Cancer,About a third of men with localized prostate cancer who are treated with EBRT or radical prostatectomy may develop distant metastasis. Find out how imaging may help to reign this in.
April 2014 ,Current Opinion in Psychiatry,Amyloid-Based Immunotherapy for Alzheimer's Disease?,This review summarizes the latest clinical trials on active and passive anti-beta-amyloid immunotherapy for the treatment of Alzheimer's disease. Where do we stand?
April 2014 ,Journal of Clinical Rheumatology,Variations and Practice in the Care of Patients With RA,There is a wide range of practice variability by rheumatologists in the management of RA. What implications does this variability have on cost of care?
April 2014 ,BMC Pulmonary Medicine,Early Discharge in Adults With Respiratory Infection,"Is early discharge really feasible, for patients with pneumonia and lower respiratory tract infection?"
April 2014 ,Medicine and Science in Sports and Exercise,Exercise as Medicine in the Management of Pancreatic Cancer,This case study describes the beneficial effects of an exercise program in a pancreatic cancer patient undergoing adjuvant treatment.
April 2014 ,BMC Musculoskeletal Disorders,Subacromial Impingement Syndrome and Pain,The SUPPORT trial investigates the long-term outcome and cost-effectiveness of these two interventions for subacromial impingement syndrome.
April 2014 ,Brain,Restoration of Sensorimotor Functions in Spinal Cord Injury,"The authors examine dual approaches to the rehabilitation of sensorimotor functions after spinal cord injury, highlighting key challenges and areas of particular promise."
April 2014 ,BMC Pulmonary Medicine,Quality of Life and Fitness in Cystic Fibrosis,What kind of physical fitness has the biggest impact on quality of life for patients with cystic fibrosis?
April 2014 ,Diabetes Care,T2DM Prevention in Prediabetes Patients Using PHEN/TPM,Can use of weight loss medications reduce the risk of diabetes?
April 2014 ,Eye & Contact Lens,Dry Eye Disease Management in Current Clinical Practice,A survey of eye care providers provides insight into the preferred diagnostic and treatment strategies for dry eye. Do practice patterns differ from current recommendations?
April 2014 ,Annals of Family Medicine,"Physical Therapy for Low Back Pain: What Is It, and When Do We Offer It to Patients?","This commentary proposes a low-cost approach to screening for and stratification of low-back pain in primary care, with referral of appropriate patients to physical therapists."
April 2014 ,Immunotherapy,Broadly Neutralizing Antibodies and Universal Vaccines,Could broadly neutralizing antibodies be effectively used as a form of passive immunotherapy for HIV and influenza?
April 2014 ,The Journal of Emergency Medicine,Management of Benign Paroxysmal Positional Vertigo,Vestibular rehabilitation with the canalith repositioning maneuver offers an alternative to medication in benign paroxysmal positional vertigo.
April 2014 ,Journal of the International Association of Providers of AIDS Care,Low Skeletal Muscle Mass in Virally Suppressed HIV Patients,This study looks at predictors of low skeletal muscle mass in middle-aged HIV-infected persons stably receiving combination antiretroviral therapy.
April 2014 ,BMC Clinical Pathology,High Expression of miRNA-21 in Node Positive NSCLC,Does miRNA-21 expression have prognostic value in non-small cell lung cancer?
April 2014 ,American Heart Journal,Hemodynamic Support With Impella 2.5 vs IABP in High-Risk PCI,What's the learning curve associated with initial introduction of the Impella 2.5. Clinical trials?
March 2014 ,Pharmacogenomics,Pharmacogenomics of Oral Antiplatelet Drugs,Should pharmacogenetic testing be done before prescribing antiplatelet drugs for coronary artery disease? This review presents the latest evidence.
April 2014 ,American Journal of Public Health,Previous Exposure to HCV Among Persons Born During 1945-1965,"What accounts for the high prevalence of HCV infection among persons born during 1945-1965, and how can clinicians ensure proper treatment for this cohort of patients?"
April 2014 ,Alimentary Pharmacology & Therapeutics,The Efficacy of Anti-TNF Agents for Ulcerative Colitis,Does this latest study advocate the use of anti-TNF agents in the treatment of ulcerative colitis?
February 2014 ,Journal of the National Cancer Institute,"Aspirin, NSAIDs, and Acetaminophen and Ovarian Cancer Risk ",Does a low-dose aspirin-a-day keep ovarian cancer at bay?
April 2014 ,Current Opinion in Gastroenterology,Advances in Celiac Disease,"As celiac disease becomes more prevalent, what does the newest research tell us about the pathophysiology of the disease, including in children, and how it is most effectively diagnosed?"
May 2014 ,Journal of the American Geriatrics Society,25-Hydroxyvitamin D and Cognitive Function in Older Adults,Is vitamin D supplementation beneficial to cognitive function in older adults?
May 2014 ,American Journal of Cardiovascular Drugs,Management of Microvascular Angina Pectoris,"Patients with stable MVA have excellent long-term prognoses, but often present with persistent and/or worsening of angina symptoms. What gives?"
May 2014 ,BMC Pulmonary Medicine,Esomeprazole and Pulmonary Exacerbations in Cystic Fibrosis,Do proton pump inhibitors promote pulmonary exacerbations in patients with cystic fibrosis?
May 2014 ,Spine,Opioids vs Other Treatments for Chronic Low Back Pain,How do opioids compare with other methods of pain management? This review examines the evidence for treating chronic low back pain.
May 2014 ,European Heart Journal,Everolimus-Eluting Bioresorbable Vascular Scaffolds for STEMI,What's the feasibility of the everolimus-eluting bioresorbable vascular scaffolds for the treatment of patients presenting with STEMI?
May 2014 ,Journal of the American College of Cardiology,Comparison of Wave-Free Ratio and Resting Pd/Pa With FFR,Zero-in on the diagnostic accuracy of instantaneous wave-free ratio (iFR) and resting distal coronary artery pressure/aortic pressure (Pd/Pa) with respect to hyperemic fractional flow reserve (FFR).
May 2014 ,BMC Musculoskeletal Disorders,"The Efficacy of Duloxetine, NSAIDs, and Opioids in OA",Is duloxetine superior to other commonly used oral treatments for osteoarthritis?
April 2014 ,Alimentary Pharmacology & Therapeutics,The Incidence of Advanced Neoplasia After Polypectomy,What is the impact of post-polypectomy surveillance colonoscopy on colorectal cancer incidence and mortality?
April 2014 ,Europace,LV Lead Stabilization to Retain CRT at Long Term,Is it possible to predict lead dislodgement?
April 2014 ,HIV Medicine,Mortality of HIV+ Youth Following Transition to Adult Care,What can be done to decrease the mortality rate of perinatally infected young HIV patients after transitioning to adult care?
April 2014 ,BMC Psychiatry,Delayed Sleep Onset in Depressed Young People,This study explored the prevalence and patterns of delayed sleep onset among depressed young people. How did substance use factor in?
April 2014 ,BMC Musculoskeletal Disorders,"Adverse Events After Manual Therapy for Neck, Back Pain",A new study takes a look at the occurrence of adverse events after manual treatment for neck or back pain. Which are the most common?
April 2014 ,Arthritis Research & Therapy,NK4 Therapy: A New Approach to RA Treatment,NK4 treatment could be a possible therapeutic option in combating RA.
April 2014 ,Kidney International,The Roles of GLP-1R Signaling in Diabetic Nephropathy,"What does this latest study tell us about the role of GLP-1 in the pathogenesis of diabetic nephropathy, and how could clinicians use this information to treat patients?"
April 2014 ,AIDS,Impaired Semen Quality in HIV Patients Under Stable ART,This study investigates the impact of HIV and ART on sperm quality and protein composition.
April 2014 ,Wounds,Laparoscopic Compared to Open Gastrectomy,Compare long-term oncologic results of performing laparoscopic vs open gastrectomy.
April 2014 ,Immunotherapy,Influenza Vaccination in Immunocompromised Patients,"Learn about the clinical significance of the influenza virus infection and vaccine safety in HIV infected individuals, solid-organ and stem-cell transplant recipients and patients receiving biological agents."
April 2014 ,Current Opinion in Pulmonary Medicine,Tuberculosis: Clinical Trials and New Drug Regimens,Be in-the-know with this TB drug update.
April 2014 ,Current Opinion in Neurology,Antiepileptogenesis in Humans: Ways to Move Forward,"While there are many effective anti-seizure drugs, none have been shown to prevent epilepsy after stroke, TBI, or in brain tumors. What's the status of research, and where do we go from here?"
April 2014 ,American Heart Journal,Target Vessel Revascularization in Older Patients Undergoing PCI,Find out more about determining the need for repeat revascularization in older patients after PCI.
May 2014 ,BMC Urology,"Surgeon Variability Affects Oncologic, Functional Outcomes",A new study explores the outcome variations following radical prostatectomy for prostate cancer. How do they differ between surgeons?
May 2014 ,Human Reproduction,IVF Culture Medium and Post-natal Weight in Humans,"Does the culture medium used in IVF affect the long-term growth, development, and health of IVF children?"
May 2014 ,American Journal of Transplantation,Donor-Specific HLA Alloantibodies in Liver Transplantation,"Advances in intensive care, immunosuppression, and disease management have dramatically improved liver allograft survival. What role is played by donor-specific HLA antibodies?"
May 2014 ,Current Opinion in Ophthalmology,"AREDS2: Perspectives, Recommendations, and Questions","This review offers a perspective on the findings from the AREDS2 trial. The results are in, but important questions remain."
May 2014 ,Nephrology Dialysis Transplantation,Ferric Carboxymaltose for Anemia and Impaired Renal Function,How well do patients with anemia and impaired renal function respond to ferric carboxymaltose? This new study looks at recent data.
May 2014 ,BMC Pulmonary Medicine,Timing of Noninvasive Ventilation Failure,"What are the causes, risk factors and potential remedies of non-invasive ventilation failure?"
May 2014 ,American Journal of Clinical Pathology,SATB2 as a Diagnostic Marker for Tumors of Colorectal Origin,This study indicates that the SATB2 protein may serve as a promising marker for determining colorectal origin of metastatic cancers.
May 2014 ,BMC Ophthalmology,Overnight Orthokeratology Compared With Atropine in Myopia,The authors investigate the efficacy of these two methods in controlling the progression of myopia. How do they compare?
May 2014 ,Headache,1-Day Behavioral Intervention in Depressed Migraine Patients,Can a one-day workshop targeting psychological flexibility help patients with comorbid migraine and depression?
May 2014 ,Diabetes Care,The Reality of Type 2 Diabetes Prevention,Do community-based programs really prevent type 2 diabetes?
May 2014 ,BMC Musculoskeletal Disorders,The Clinical Course of Low Back Pain,A new study sheds light on the clinical course of low back pain and uncovers a pattern in the results of RCTs and observational studies.
May 2014 ,BMC Family Practice,Chronic Conditions Among Multimorbid Patients in Primary Care,Many older people have multiple chronic conditions. To what extent is there agreement between self-reported and physician-reported chronic conditions among multimorbid patients?
May 2014 ,Pacing and Clinical Electrophysiology,Effect of Anxiety and Depression on Symptoms Attributed to AF,"Learn more about the crossroads of depression, anxiety, and atrial fibrillation."
May 2014 ,Wounds,Serial Sharp Debridement of Diabetic Foot Ulcers,What's the net effect of debridement with clostridial collagenase ointment and debridement --for foot ulcers in patients with diabetes.
May 2014 ,The Journal of Emergency Medicine,Review of Hypnosis for Clinical Emergency Care,"Does hypnosis have a place in emergency medicine? If so, why is it not more widely used?"
May 2014 ,Diabetes,Limited Recovery of Beta-Cell Function After Gastric Bypass,Is improvement in beta-cell function after gastric bypass mediated by the GI tract?
May 2014 ,American Heart Journal,Contraindications to Oral Anticoagulation in Atrial Fibrillation,What factors are associated with oral anticoagulant contraindications & how do they influence prescribing practices?
May 2014 ,The Journal of Invasive Cardiology,Predictors of Complications During Chronic Total Occlusion PCI,"Find out more about clinical, angiographic, and procedural factors associated with increased risk of periprocedural complications during chronic total occlusion percutaneous coronary intervention."
May 2014 ,Current Opinion in Allergy and Clinical Immunology,Eosinophils in the Pathogenesis of Paediatric Severe Asthma,Find out why children with asthma shouldn't be treated as smaller versions of adults.
May 2014 ,American Journal of Critical Care,Arterial Catheter for Glucose Control in Critically Ill,Is blood from an arterial catheter safe and effective for glucose monitoring -- in patients on intensive insulin therapy?
May 2014 ,Pain Management Nursing,Pain Prevalence and Management in Pediatric Population,"New research, regulatory guidelines, and practice initiatives have improved pain management in infants, children, and adolescents, but obstacles remain. . ."
May 2014 ,Seminars in Respiratory and Critical Care Medicine,Rheumatoid Arthritis and Lung Disease,What do you know about the connections between rheumatoid arthritis and lung disease?
May 2014 ,Rheumatology,Udenafil vs Amlodipine in Secondary Raynaud's Phenomenon,Is udenafil or amlodipine more effective in the treatment of secondary Raynaud's phenomenon?
May 2014 ,Annals of Oncology,Megestrol in Advanced Breast Cancer Postmenopause,"Megestrol acetate has a longstanding history in the treatment of breast cancer, but recently it's being used less often due to the advent of newer agents. Can this relative bargain make a comeback -- in the third world?"
May 2014 ,Europace,Applicability of the Iterative Technique for CRT Optimization,Gain insight into the guideline driven use of iterative atrioventricular delay optimization in patients undergoing cardiac resynchronization therapy.
May 2014 ,Personalized Medicine,Genotype-Guided Use of Oral Antithrombotic Therapy,Do the genetic factors that affect warfarin metabolism also affect the novel oral anticoagulants?
May 2014 ,BMC Anesthesiology,Three Techniques for Ultrasound Guided Femoral Nerve Block,What is the optimal positioning of the local anesthetic for a femoral nerve block?
May 2014 ,Alimentary Pharmacology & Therapeutics,Treatment Costs in Ulcerative Colitis and Crohn's Disease,How much of a burden does the treatment of ulcerative colitis and Crohn's disease place on our healthcare system? This new study explains.
May 2014 ,BMC Musculoskeletal Disorders,Endoscopic Treatment for Lumbar Infectious Spondylitis,"In this report, a new minimally invasive technique for lumbar infectious spondylitis is described. Is this approach an effective alternative to open surgery?"
May 2014 ,BMC Psychiatry,Comorbidity of Dementia,What are the common comorbidities associated with dementia in older patients?
May 2014 ,HIV Medicine,Management of CV Conditions and Diabetes HIV+ Adults,What are the risks of combining antiretroviral treatment with drugs prescribed for cardiovascular disease and diabetes in HIV-infected patients?
May 2014 ,The British Journal of Dermatology,Diagnosing and Treating Psoriatic Arthritis: An Update,"Psoriatic arthritis affects approximately one in four patients with psoriasis, and can cause severe disability. What should the dermatologist know about diagnosis and management?"
May 2014 ,Cardiovascular Diabetology,Liraglutide Decreases Carotid IMT in Patients With T2DM,Does this GLP-1 receptor agonist decrease subclinical atherosclerosis?
May 2014 ,European Heart Journal,Prognostic Models for Stable Coronary Artery Disease,Could these prognostic models be used in clinical practice to support risk stratification for patients with CAD?
May 2014 ,Wounds,Topical Combination Therapy in Wound Healing,See comparative images of wounds treated with topical oxygen therapy and negative pressure vs those treated with saline irrigation.
May 2014 ,BMC Clinical Pathology,Colorectal Cancer in Guadeloupe and Martinique,Colorectal cancer in Guadeloupe and Martinique has increased five-fold in 25 years. Do clinicopathological characteristics differ between the 2 nations?
May 2014 ,Chinese Clinical Oncology,Biomarker Threshold Selection and Independent Evaluation,Development of targeted therapies is accelerating in response to widespread identification of hypothesized biomarkers.
May 2014 ,Journal of Viral Hepatitis,Efficacy and Safety of Telaprevir Triple Therapy for HCV,Is telaprevir triple therapy considered to be safe and effective for patients with HCV genotype 1?
May 2014 ,American Journal of Clinical Dermatology,Medical Adherence to Acne Therapy: A Systematic Review,Why is there so often poor adherence to acne therapy?
May 2014 ,International Journal of Clinical Practice,GLP-1 Receptor Agonists vs. DPP-4 Inhibitors for T2DM,This review examines the clinical differences and similarities between the two primary drug classes for treatment of type 2 diabetes mellitus. When is each most appropriate?
May 2014 ,Malaria Journal,Imported falciparum Malaria Among Adults in the ICU,This article reviews available data to guide clinicians caring for adults with imported malaria in an intensive care unit.
May 2014 ,BMC Infectious Diseases,Point-of-Care Urine Test for TB Screening Among HIV+ Adults,How accurate is the rapid urine LAM test for TB screening among newly-diagnosed HIV-infected adults?
May 2014 ,Future Virology,Antiviral Vaginal Rings for Preventing HIV in Women,Could this device be the solution to HIV prevention in women?
May 2014 ,Eye & Contact Lens,Topical Tacrolimus 0.03% in Vernal Keratoconjunctivitis,How effective is topical tacrolimus alone in the treatment of vernal keratoconjunctivitis? This study compares the efficacy of this agent when used alone or combined with olopatadine.
May 2014 ,BMC Pulmonary Medicine,Beclomethasone/Formoterol vs Fluticasone/Salmeterol in COPD,Find out which inhaler combo is quicker on the draw -- for breath in patients with COPD.
May 2014 ,Cardiovascular Diabetology,Cardiovascular MicroRNAs and Diabetic Heart Disease,Can microRNA be used to detect heart disease earlier in patients with diabetes?
May 2014 ,European Heart Journal,Pentaerithrityl Tetranitrate in Chronic Stable Angina,Will adding PETN improve exercise tolerance in patients with chronic stable angina?
May 2014 ,Diabetes Care,SGLT2 Inhibition and Glycemic Control in Type 1 Diabetes,Are SGLT2 inhibitors safe and effective in type 1 diabetes?
" Open Access Journal of Plastic Surgery, May 2014 ",ePlasty,"Single Use PICO NPWT Device on Surgical, Traumatic Wounds",Learn more on this novel NPWT system and how it can benefit postoperative and posttraumatic wounds.
May 2014 ,Future Cardiology,Optimal Aspirin Dose in Acute Coronary Syndromes,"The complex antiplatelet therapy landscape makes it difficult to identify the optimal aspirin dose for minimizing risk, while complying with the clinical guidelines."
May 2014 ,Annals of Family Medicine,Therapeutic Massage for Chronic Neck Pain,Are patients who undergo therapeutic massage for chronic neck pain receiving a sufficient dose? What's the optimal frequency and session length for relief?
May 2014 ,Neurosurgical Focus,The Early Days of Hemostasis in Neurosurgery,The authors review the historical progression of hemostatic techniques since the beginning of the early modern era of neurosurgery.
May 2014 ,The Journal of Invasive Cardiology,TAVI in Patients With LV Dysfunction,What are the outcomes of patients with severe aortic stenosis and left ventricular dysfunction undergoing TAVI?
May 2014 ,Diabetes,Cardiac Arrhythmias During Hypoglycemia in T2DM with CV Risk,"Why does hypoglycemia trigger arrhythmias, and who is at risk?"
May 2014 ,Exercise and Sport Sciences Reviews,Restoring Symmetry: Clinical Applications of Cross-Education,"Learn more on the 'restoring symmetry' hypothesis, and what role this approach can play in neurologic and orthopedic rehabilitation."
May 2014 ,Journal of the National Cancer Institute,Baseline Selenium Status and Effects of Selenium and Vitamin E,What amount of vitamin E and selenium should men consume to reduce prostate cancer risk?
May 2014 ,Endocrine Practice,Treatment of Gastroenteropancreatic Neuroendocrine Tumors,"Neuroendocrine tumor treatment now includes hormone therapy, chemotherapy, and targeted biologic therapy."
May 2014 ,BMC Pulmonary Medicine,Impact of Prevalence and Severity of COPD on Lung Cancer,Recent studies suggest that coexistence of chronic obstructive pulmonary disease (COPD) might be independently related to a worse prognosis for lung cancer.
May 2014 ,BMC Musculoskeletal Disorders,Computer-Assisted Surgery and Alignment in Revision TKA,How does the use of computer-assisted surgery in revision TKA affect postoperative prosthetic alignment?
May 2014 ,Cardiovascular Diabetology,Cardiovascular Safety of Saxagliptin in Patients With T2DM,Does this DPP-4 inhibitor increase risk of myocardial infarction or stroke?
May 2014 ,BMC Pulmonary Medicine,Non-Pharmacologic Interventions for Asthma During Pregnancy,Are non-drug therapy options effective for pregnant women with asthma?
May 2014 ,Cardiovascular Diabetology,Cardiovascular Guidelines: Attenuating Controversy,Are clinical guidelines you rely on free of financial conflict of interest? Probably not. How can this controversial issue be fixed?
May 2014 ,Journal of Cardiovascular Electrophysiology,Ablation for Persistent AF Without Circumferential PVI,Find out about the clinical outcome of a pure linear ablation approach without circumferential pulmonary vein isolation over 5-plus years follow-up.
May 2014 ,Critical Care Medicine,Efficacy and Safety of Prone Positional Ventilation in ARDS,Does ventilation in the prone position reduce mortality in patients with severe ARDS?
May 2014 ,BMC Urology,Simvastatin Improves Sexual Health QoL in Older Men With ED,"In a secondary analysis, researchers found that older men with ED who took 40 mg of simvastatin daily realized a significantly improved sexual health-related quality of life."
May 2014 ,American Journal of Pharmaceutical Education,Evolution of Self-care Education,Are pharmacists prepared to educate the increasing number of patients taking OTC medications?
May 2014 ,Respiratory Research,"Changes in Gene Expression From Patients With Asthma, Rhinitis",Discover more about how dsRNA changes transcriptional profiles of primary nasal and bronchial epithelial cells - from patients with allergic rhinitis.
May 2014 ,The Gerontologist,"Elder Abuse: Research, Practice, and Health Policy","This paper examines the epidemiology of elder abuse -- whether psychological, physical, sexual, or by neglect -- and its implications for future research, practice, and policy."
May 2014 ,Journal of the National Cancer Institute,Survival in Cancer Patients in and out of Clinical Trials,What's the relationship between trial participation and clinical outcomes for cancer patients?
May 2014 ,BMC Anesthesiology,Predicting Mortality in Bacteremic Patients With Shock,What factors are capable of impacting hospital mortality in patients with septic shock?
May 2014 ,AccessMedicine from McGraw-Hill,Treatment of Hepatitis C: At Last the Holy Grail,"Finally, effective treatment can be achieved using an oral tablet containing 2 direct-acting antiviral agents. Read this quick overview."
May 2014 ,Journal of Clinical Rheumatology,OMERACT Measurement for Chronic Gout Studies,What are the most important concerns of patients with gout?
May 2014 ,American Journal of Clinical Pathology,Low ER+ Breast Cancer: Is This a Distinct Group?,Are breast cancers expressing ER at low levels different from the usual ER+ tumors? This study looked at the morphologic characteristics of this uncommon subset of breast cancers.
May 2014 ,BMC Pulmonary Medicine,Benefits of Whole-Body Vibration to People With COPD,Find out how this non-pharmacologic therapy creates ripples of good vibrations -- in patients with COPD.
May 2014 ,Cardiovascular Diabetology,Liraglutide-Induced Body Changes & Cardiac Markers,New research sheds light on how weight loss occurs in patients receiving GLP-1 agonists.
May 2014 ,European Heart Journal,Choline/Betaine Prognostics Depend on Trimethylamine-N-Oxide,Find out why these biomarkers for coronary heart disease should always go with their gut. . .
May 2014 ,Emerging Infectious Diseases,HPV in Oropharyngeal Cancer Before Vaccine Introduction,What impact has the HPV vaccine had on oropharyngeal cancer?
May 2014 ,Clinical Journal of Oncology Nursing,Gastrointestinal Nurse Navigation: A Novel Role,Get tips on developing a GI Nurse Navigator role as part of a multidisciplinary GI cancer program & find out more about the importance of tracking specific quality metrics.
May 2014 ,Rheumatology,PEGylated Drugs in Rheumatology,"What PEGylated drugs are currently available for use in rheumatological diseases? This article reviews their efficacy, drawbacks current clinical trials."
May 2014 ,International Journal of Epidemiology,Preventing the Onset of Major Depressive Disorder,Is major depression preventable? This meta-analysis of preventive interventions aimed to determine what might work.
June 2014 ,International Ophthalmology Clinics,Obesity and Weight Reduction in IIH,How much weight loss is necessary to relieve symptoms of intracranial hypertension?
June 2014 ,Cardiovascular Diabetology,Distribution of CVD and Retinopathy in Patients With T2DM,Do new classification systems for CKD underestimate the burden of CVD and retinopathy in patients with diabetes?
June 2014 ,Diabetes,Proinsulin-Transferrin Fusion Protein as an Insulin Analog,This new insulin analog is specific to the liver. Will it offer advantages over conventional insulin?
June 2014 ,Nanomedicine,Lipid-Based Nanomedicines for Type-Specific Ovarian Cancer,"Epithelial ovarian cancers are currently all treated with the same chemotherapeutic regimen, but delivery via lipid-based nanoparticles has the potential to allow greater specificity by cancer subtype."
June 2014 ,Respiratory Research,Comorbid Factors That Increase COPD Assessment Scores,What does it mean for patients with COPD to have a 'high CAT'?
June 2014 ,BMC Musculoskeletal Disorders,Clinical Study of the Pronator Quadratus Muscle,Gain a better understanding of the anatomical features of the pronator quadratus muscle and the viability of PQ muscle sparing surgery for distal radius fractures.
June 2014 ,Pediatric Pharmacotherapy,Methylnaltrexone for Opioid-Induced Constipation in Children,Is methylnaltrexone an effective treatment option for children with opioid induced constipation?
May 2014 ,Journal of the American Geriatrics Society,MoCA-MIS Predicts Conversion From MCI to Alzheimer's Disease,This study evaluated the efficacy of a widely used 10-minute cognitive screening test in predicting which individuals with MCI are at high risk of conversion to Alzheimer's disease.
May 2014 ,Journal of the National Cancer Institute,Better Therapeutic Trials in Ovarian Cancer,"Review strategies to improve early-phase screening, therapeutic evaluation, and more for clinical trials -- in response to an evolving landscape of scientific, regulatory, and funding priorities."
May 2014 ,AccessMedicine from McGraw-Hill,Imaging in the Diagnosis of Disorders of Consciousness,Can imaging and electrophysiologic techniques help distinguish between patients with persistent vegetative state and those in a minimally conscious state?
May 2014 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Importance of Hospital Entry: Walk-in STEMI and Primary PCI,Which patients with STEMI do better? Those who arrive by ambulance or those who walk in?
May 2014 ,Clinical Endocrinology,Longitudinal Changes in HDL and CV Events in Older Adults,Does a significant decrease in HDL increase risk of CV disease in patients older than 50?
May 2014 ,BMC Gastroenterology,Altering Lifestyle to Reduce Risk of Colorectal Cancer,"When patients are at a high risk for developing colorectal cancer, how likely are they to alter their lifestyle choices to help prevent the disease? This new study take a look."
May 2014 ,Current Opinion in Neurology,TMS for the Diagnosis and Treatment of Epilepsy,"Recent advances have shown TMS to be a valuable tool with diagnostic, prognostic and therapeutic potential in the field of epilepsy."
May 2014 ,Kidney International,New Magnetic Resonance Imaging Methods in Nephrology,"How is MRI used for renal function imaging, and how can clinicians ultimately use MRI for the diagnosis and monitoring of major kidney diseases?"
May 2014 ,Personalized Medicine,"Cancer Pharmacogenomics, Adoption by Oncologists and Benefit",Do oncologists need more information about cancer pharmacogenomics testing?
May 2014 ,Alimentary Pharmacology & Therapeutics,Budesonide-MMX for Mild-to-Moderate Ulcerative Colitis,"Should clinicians consider adding the glucocorticosteroid, budesonide-MMX, to treatment regimens for mild-to-moderate ulcerative colitis?"
May 2014 ,BMC Musculoskeletal Disorders,Self-administered Tests for Pelvic Girdle Pain in Pregnancy,Are self-administered tests an effective means of identifying pelvic girdle pain in pregnant women?
May 2014 ,BMC Neurology,Sex of Acute Stroke Patients and Effectiveness of rt-PA,Do women show more frequent recanalization and better recovery after intravenous rt-PA treatment for acute stroke compared with men?
May 2014 ,Pharmacogenomics,How Common Are Drug and Gene Interactions?,"Drug-drug interactions are a widely recognized cause of adverse drug reactions, but drug-gene interactions can be a potential source of ADRs as well. How common are they?"
June 2014 ,Headache,Pediatric Headache,"This article presents a comprehensive overview of pediatric headache, from epidemiology, genetics, and classification to diagnosis, treatment options, and prevention strategies."
June 2014 ,JAIDS: Journal of Acquired Immune Deficiency Syndromes,HIV Outcomes in HBV Coinfected Individuals on HAART,How does HBV coinfection affect the outcomes in HIV patients receiving HAART?
June 2014 ,Critical Care Medicine,Interaction of Vasopressin and Corticosteroids in Septic Shock,What's the real story between vasopressin and corticosteroids in septic shock?
June 2014 ,AIDS,Impact of ART Response on Life Expectancy in HIV+ Adults,This study estimates life expectancies of HIV-positive patients according to response to antiretroviral therapy.
June 2014 ,Current Opinion in Nephrology and Hypertension,Safety of Medical Therapy in Patients With CKD and ESRD,"Is medical therapy safe in patients with CKD and ESRD, and how can clinicians ensure that the medications they're prescribing don't produce dangerous adverse events?"
June 2014 ,Pediatric Critical Care Medicine,Safety of Sildenafil in Infants,How safe and effective is this repurposed erectile dysfunction therapy -- as an option for the treatment of pulmonary hypertension in young infants?
June 2014 ,Eye,Anti-VEGF Agents for Proliferative Diabetic Retinopathy,This review summarizes evidence on the use of anti-VEGF agents in the treatment of proliferative diabetic retinopathy.
June 2014 ,BMC Urology,Nadir PSA Levels Are Prognostic Factors in Prostate Cancer,Learn more on the role nadir PSA values play in predicting the prognosis of patients with metastatic prostate cancer.
June 2014 ,Applied Radiology,New PET Tracers for Dementia Evaluation,"Two new amyloid imaging tracers are proving useful in amyloid PET imaging for AD diagnosis, but limitations must be addressed before this tool can significantly enhance diagnostic accuracy."
June 2014 ,American Journal of Transplantation,DDAs for Chronic HCV Infection in Liver Transplant Patients,"Direct acting antiviral agents provide new opportunities for treatment of HCV recurrence, but are there pitfalls?"
June 2014 ,BMC Ophthalmology,Cost-Effectiveness of the Argus II Retinal Prosthesis,Is this retinal prosthesis more economically advantageous than usual care for treating retinitis pigmentosa?
June 2014 ,Journal of the American Geriatrics Society,Surgical Care and Complications in Elderly Adults,"This study compared the distribution of surgical cases and outcomes in five age categories. How did procedures, hospitals visited, and complications differ according age?"
June 2014 ,Current Opinion in Rheumatology,Safety Profile of Anti-gout Agents: An Update,This review highlights recent data on the safety of drugs used in gout.
June 2014 ,European Heart Journal,Heart Failure With Preserved Ejection Fraction,Does heart failure with preserved ejection fraction simply represent a collection of co-morbidities rather than a pathophysiologically distinct entity?
June 2014 ,American Journal of Public Health,Outcomes Related to Third Molar Removal or Retention,"Prophylactic removal of asymptomatic third molars in young adults is common, but remains controversial. How do long-range outcomes compare for removal vs. retention?"
June 2014 ,American Heart Journal,Drivers of Hospitalization for Patients With AF,Learn more about the frequency and predictors of hospitalization in patients with AF.
June 2014 ,Oncology Nursing Forum,Pegfilgrastim-Induced Pain in Patients With Lymphoma,"Growth factors, such as pegfilgrastim or filgrastim, have reduced the incidence, duration, and severity of chemotherapy-related neutropenia, but what are the common side effects?"
June 2014 ,Annals of Surgery,Benchmarking Outcomes in the Critically Injured Burn Patient,"This study serves as a benchmark in burn care, comparing interventions, outcomes and mortality among major burn patients."
June 2014 ,Alimentary Pharmacology & Therapeutics,Fecal Microbiota Transplantation in Adults and Children,"How safe and effective is fecal microbiota transplantation for various gastrointestinal diseases in both adults and children, and is it becoming a common treatment?"
June 2014 ,Future Virology,Dengue Vaccine Development: Challenges and Opportunities,Where are we in the progression toward an effective dengue vaccine?
June 2014 ,American Journal of Kidney Diseases,Nephropathy in Illicit Drug Abusers: A Postmortem Analysis,Could intravenous drug users be at an increased risk for nephropathy and chronic kidney disease? This new study explores the connection.
June 2014 ,Pain Management Nursing,Older Adults' Pain Communication During Medical Visits,How much time should you allow older patients for pain-talk?
June 2014 ,Annals of Surgery,Safety Delays Before Surgery for Acute Appendicitis,"Short organizational delays before appendicectomy may improve provision of surgical services, but is the delay safe for the patient?"
June 2014 ,Rheumatology,Maintenance Therapy of Lupus Nephritis With MMF or AZA,Is mycophenolate or azathioprine a better choice for maintenance therapy in patients with lupus nephritis?
June 2014 ,BMC Family Practice,CRP Testing in Acute Cough/Respiratory Tract Infection,Could routine CRP testing in patients with acute cough or respiratory tract infection reduce antibiotic prescribing and further diagnostics without compromising outcomes?
June 2014 ,International Journal of Impotence Research,Effects of Daily Low-Dose PDE5 Treatment in ED Patients,Find out about the additional beneficial effects of daily dosing with the PDE5 inhibitor udenafil in patients with ED.
June 2014 ,Journal of Cardiovascular Electrophysiology,Estimated Local Conduction Velocity in Atrial Flutter,Get the facts on correlates related to the atrial flutter reentry circuit in the right atrium.
June 2014 ,BMC Endocrine Disorders,Association Between MetS and Fractures: A Meta-analysis,Are patients with metabolic syndrome at risk for fractures?
June 2014 ,Journal of the American College of Cardiology,Optimal Medical Therapy Goals for US Adults With CAD,What percentage of patients with CAD have optimal risk factor management?
June 2014 ,Diabetes Care,Intensive vs Intermediate Glucose Control in SICU Patients,Does intensive glucose control decrease the risk of surgical site infections in SICU patients?
June 2014 ,BMC Musculoskeletal Disorders,Effects of Exercise on Depression in Rheumatic Disease,Could exercise improve depressive symptoms in patients with rheumatic diseases? This review examines the effects.
June 2014 ,Nanomedicine,Liposomes Targeted to Dendritic Cells for Cancer Vaccines,This review presents a novel targeted vaccine strategy to activate and deliver antigens to dendritic cells in advanced cancers.
June 2014 ,The Journal of Invasive Cardiology,Transradial vs Transfemoral Coronary Intervention for AMI,"When cardiogenic shock occurs after AMI, which access point is safer for PCI?"
June 2014 ,BMC Infectious Diseases,Increased Incidence of Invasive Bacterial Disease in COPD,What is the association between COPD and invasive bacterial infection?
June 2014 ,Seminars in Respiratory and Critical Care Medicine,Pulmonary Manifestations of Systemic Lupus Erythematosus,"Learn more about the clinical presentation, pathogenesis, pathology, management, and prognosis of these SLE-associated lung conditions."
June 2014 ,BMC Gastroenterology,Barriers Impeding Serologic Screening for Celiac Disease,"What are some of the reasons why patients may not get tested for celiac disease, and how can these rates be improved upon?"
June 2014 ,European Heart Journal,CT Angiography and Perfusion to Assess Coronary Artery Stenosis,Find out about a perfect pairing to identify patients with flow limiting CAD.
June 2014 ,Rheumatology,Role of DMARDs in Reducing Immunogenicity of TNF Inhibitors,Concomitant MTX may reduce the immunogenicity of anti-TNFs in chronic inflammatory diseases.
June 2014 ,Personalized Medicine,Recent Advances in Antiplatelet Pharmacogenomics,How do genetic polymorphisms affect metabolism of antiplatelet agents and subsequent risk of bleeding?
June 2014 ,Alimentary Pharmacology & Therapeutics,Postoperative Crohn's Disease Maintenance,Are thiopurines and anti-TNF agents recommended in the prevention of postoperative Crohn's disease recurrence?
June 2014 ,European Heart Journal,Diuretic Response in Acute Heart Failure,Find out what factors have the greatest impact on the effectiveness of diuretics in acute heart failure.
June 2014 ,Future Microbiology,Immunization for P. Aeruginosa in Critically Ill Patients,Pseudomonas aeruginosa is one of the most common causes of nosocomial infection in intensive care unit patients. Where do we stand on vaccine development?
June 2014 ,BMC Infectious Diseases,Predicting Embolic Events in Infective Endocarditis,What factors are associated with the risk of embolism in patients with infective endocarditis?
June 2014 ,Skin Therapy Letter,Rosacea: An Update on Medical Therapies,"Rosacea, a common, chronic cutaneous condition affecting the face, can create embarrassment, anxiety, and low self-esteem. What therapies are currently available?"
June 2014 ,Journal of Pediatric Psychology,Mindfulness and Acute Experimental Pain Among Adolescents,This study tested a novel mindful attention manipulation on adolescent's pain responses. Can it ameliorate pain outcomes?
June 2014 ,Critical Care Medicine,Corticosteroids and Delirium in Acute Lung Injury,"Outside the ICU setting, corticosteroids are a recognized risk factor for delirium, but what's their relationship with delirium in critically ill patients?"
June 2014 ,European Heart Journal,Bone Marrow Cells and CABG for Myocardium Regeneration,Does adding bone marrow cells during CABG improve LV function and clinical symptoms?
June 2014 ,BMC Pulmonary Medicine,Exacerbations in Patients With COPD Receiving Physical Therapy,Does protocol-directed physical therapy prevent and/or postpone COPD exacerbation?
June 2014 ,Journal of the American College of Cardiology,Prognostic Value of BARC Bleeding Complications in STEMI,Learn more about comparisons of BARC-defined bleeding complications with existing bleeding definitions -- in patients with STEMI.
June 2014 ,Medicine and Science in Sports and Exercise,Mediators of Exercise Effects on Fatigue in Cancer Survivors,Gain a better understanding of the mediators of exercise intervention effects on cancer-related fatigue.
June 2014 ,The Journal of Invasive Cardiology,Fractional Flow Reserve and Coronary Flow Reserve,"Functional assessment of coronary lesions requires diagnostic parameters like fractional flow reserve and coronary flow reserve, but stenosis hemodynamics might require a different approach . . ."
June 2014 ,American Journal of Epidemiology,Changes in LDL Cholesterol Levels After Acute MI,The findings of this study support the use of intensive statin therapy in post-MI patients to reduce the risk of recurrent ischemic events and death.
June 2014 ,Emerging Infectious Diseases,Characteristics of Primary Pulmonary Coccidioidomycosis,"This study examines characteristics of patients with coccidioidomycosis with hopes to better guide diagnosis, treatment, and prognosis."
June 2014 ,BMC Infectious Diseases,Oral Antibiotic Therapy for Treating Infective Endocarditis,Are oral antibiotics effective when treating infective endocarditis?
June 2014 ,Alcohol and Alcoholism,Genetic and Environmental Interplay in Adolescent Drinking,"This study reviewed recent research on the interplay of genes, environment and epigenetic factors in risky drinking in adolescents. What role do these factors play in neurobiological development?"
June 2014 ,Infection Control and Hospital Epidemiology,Preventing C. diff Infections in Acute Care Hospitals,What strategies can be used to prevent the spread of C. diff infection in acute care hospitals?
June 2014 ,Cardiovascular Ultrasound,Ischemic Mitral Regurgitation: Predictors and Prognosis,This study aimed to determine the predictors and prognosis of early ischemic mitral regurgitation after percutaneous coronary intervention for ST-elevation myocardial infarction.
June 2014 ,Current Opinion in Rheumatology,Uricosuric Drugs: Once and Future Therapy for Hyperuricemia?,Promising new drugs could increase the renal clearance of uric acid and thereby provide better control of hyperuricemia.
June 2014 ,Clinical Endocrinology,Effect of 25(OH) D in PHPT & Coexistent Vitamin D Deficiency,Does correction of vitamin D deficiency cause hypercalcemia and hypercalciuria in patients with primary hyperparathyroidism?
June 2014 ,Journal of the American College of Cardiology,Post-FDA Approval Study With a Continuous Flow LVAD,Are results with the HeartMate II LVAD in a commercial setting comparable to results during clinical trials?
July 2014 ,Clinical Endocrinology,Impulse Control & Dopamine Agonist-Treated Prolactinomas,Are patients receiving dopamine agonists for prolactinomas at risk for compulsive shopping and pathologic gambling?
July 2014 ,BMC Endocrine Disorders,Prevalence and Determinants of Osteoporosis in Diabetes,Are patients with diabetes at increased risk for osteoporosis?
July 2014 ,European Heart Journal,Remote vs in-Person Monitoring for ICD Follow-Up,Which follow up method is better for patient retention? The answer may surprise you. . .
July 2014 ,The Pediatric Infectious Disease Journal,Pediatric Chagas Disease in Europe,"Pediatric Chagas disease is an emerging health issue in Europe, but clinician still lack awareness to the problem."
July 2014 ,Alimentary Pharmacology & Therapeutics,The Efficacy of Anti-TNF Agents to Treat Crohn's Disease,Does the latest research tell us anything new about the efficacy of anti-TNF agents in the treatment of Crohn's disease?
July 2014 ,Journal of Viral Hepatitis,Treating Hepatitis C in Patients With Schizophrenia,What special considerations should be taken into account in the treatment of patients with hepatitis C who also have been diagnosed with schizophrenia?
July 2014 ,BMC Family Practice,Persistent Medically Unexplained Physical Symptoms,How common are patients with persistent MUPS--defined as conditions characterized by symptoms without corresponding objective findings--in general practice?
July 2014 ,BMC Oral Health,Adjunctive Chlorhexidine Mouthrinse in Gingivitis,This study assessed the effect of a microbicidal mouthrinse on matrix metalloproteinases known to contribute to periodontal disease.
July 2014 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,Phenytoin Toxicity From Cocaine Adulteration,"Phenytoin (PHT) is commonly used as a cocaine adulterant, but can lead to toxic effects. In this case, a patient developed PHT toxicity after ingesting adulterated crack cocaine."
July 2014 ,European Heart Journal,Cardiac MRI in Identifying Ventricular Arrhythmia Substrate,What's the clinical value of analyzing ventricular scar tissue to find an ablation approach in patients with ventricular arrhythmias?
July 2014 ,The British Journal of Dermatology,Epidemiology and Comorbidities of Severe Acne in Adolescence,"Do racial, ethnic, and socioeconomic differences impact the prevalence of severe acne? What medical comorbidities are commonly seen in adolescents with severe acne?"
June 2014 ,Menopause,Testosterone in Hysterectomized Women,"What does the latest research tell us about the safety and efficacy of testosterone for the treatment of sexual dysfunction, physical dysfunction, and osteoporosis in postmenopausal women?"
July 2014 ,Southern Medical Journal,Vitamin D Insufficiency/Deficiency Management,"Vitamin D deficiency is increasingly recognized in patients, but there's been no consensus on treatment regimens. How should Vitamin D deficient patients be managed?"
June 2014 ,Diabetes,Circadian Misalignment & Markers of Insulin Resistance,Does shift work increase the risk of diabetes?
June 2014 ,Schizophrenia Bulletin,Sexual Trauma and Risk of Psychosis in Prodromal Population,Is sexual trauma an important contributing factor in development of psychosis for certain high-risk individuals?
June 2014 ,Arthritis Research & Therapy,Adalimumab in Patients With RA and Over 5 Years of Therapy,This large observational study evaluates the long-term safety and effectiveness of adalimumab.
June 2014 ,Current Opinion in Neurology,Migraine and Estrogen,"Although the association between migraine and sex hormones has been repeatedly demonstrated, the exact pathophysiology has not yet been fully elucidated. What do we know?"
June 2014 ,Annals of Oncology,Bevacizumab-Pemetrexed for Advanced Nonsquamous NSCLC,Learn more about the safety and efficacy of bevacizumab maintenance with or without pemetrexed in nonsquamous nonsmall-cell lung cancer.
June 2014 ,BMC Infectious Diseases,Oral Antibiotic Regimen After IV Treatment for Osteomyelitis,IV antibiotics are often used for treatment of vertebral osteomyelitis. When is it safe to switch to oral antibiotics?
June 2014 ,Clinical Endocrinology,IGF-II: Its Role in Metabolic and Endocrine Disease,"Previously considered physiologically irrelevant, what does research now say about the function of insulin-like growth factor-II and its role in disease?"
July 2014 ,Pediatric Critical Care Medicine,Citrate Anticoagulation and Renal Replacement Therapy in PICU,Find out how to avoid risks of using regional citrate anticoagulation in the pediatric critical care population requiring renal replacement therapy.
July 2014 ,Journal of the American College of Cardiology,Early Stent Thrombosis in Patients With ACS,Learn more about the impact of thrombus burden and suboptimal stent implantation as a trigger of early stent thrombosis.
July 2014 ,Clinical Lipidology,Recalcitrant Hypercholesterolemia With Best Standard of Care,Find out what to do when guideline based therapy isn't hitting the mark for cholesterol reduction.
July 2014 ,Nephrology Dialysis Transplantation,Differential Scaling of GFR and Ingested Metabolic Burden,"Do men generally have more adverse outcomes in chronic kidney disease than women, and is there a way to estimate what the outcomes may be?"
July 2014 ,Journal of Pediatric Psychology,Pediatric eHealth Interventions: Common Challenges,"There are many challenges pediatric researchers face when planning, developing, testing, and conducting eHealth interventions. What are the crucial issues and how can they be overcome?"
July 2014 ,Future Neurology,Time to Open the Blood-Brain Barrier Gate for Biologics?,Recent advances in our understanding of the blood-brain barrier should allow for clinical investigations into the targeted delivery of biologic agents such as antibodies for brain disorders.
July 2014 ,Journal of the American College of Cardiology,Long Term Benefit of Early Metoprolol in AMI,Does early IV metoprolol before reperfusion result in fewer admissions due to heart failure?
July 2014 ,Medicine and Science in Sports and Exercise,"Adiposity, Insufficient MVPA and Cardiometabolic Health","A new study takes a look at the connection between adiposity, physical activity and the risk of cardiometabolic abnormalities among adults."
July 2014 ,BMC Musculoskeletal Disorders,Pathological Fracture and Healing of Unicameral Bone Cysts,Learn more on the prognostic factors for pathological fractures and healing of unicameral bone cysts.
July 2014 ,Journal of Cardiovascular Electrophysiology,Stroke Risk and AF Ablation With Anticoagulant by ECG,Find out more about balancing the competing risks of stroke and bleeding in patients with atrial fibrillation treated with and without oral anticoagulants.
July 2014 ,The American Journal of Gastroenterology,Consumer Use of Over-the-Counter PPIs in Patients With GERD,How closely should patients taking over-the-counter PPIs for GERD be monitored by their clinicians?
July 2014 ,Southern Medical Journal,Risk Stratification in Acute Pulmonary Embolism,Does risk stratification--either by measurement of a biomarker or the performance of an echocardiogram-- improve outcomes in patients with acute pulmonary embolism?
July 2014 ,International Journal of Clinical Practice,Drugs for Pain Associated With Postherpetic Neuralgia,"What pharmacological therapies are most effective for the treatment of neuropathic pain such as postherpetic neuralgia, MS-related pain, central poststroke pain, and HIV-related neuropathy?"
July 2014 ,Pharmacogenomics,Pharmacogenetics of Second-Generation Antipsychotics,How does genetic variation influence individual response and side effect profiles for the commonly prescribed atypical antipsychotics?
July 2014 ,AIDS,Adverse Events According to CD4 Count at the Start of ART,Are HIV patients who start ART with a higher CD4 count at greater risk of ART-related adverse events?
July 2014 ,Personalized Medicine,Highlights From the Latest Articles in Suicide Research,"These studies evaluate the relationship of anger, gender differences, and bipolar disorder to suicide risk."
July 2014 ,Cardiovascular Diabetology,Different ARBs and Incidence of Diabetes,Do these common antihypertensives increase risk for diabetes?
July 2014 ,Neurosurgical Focus,Calculations in Spine Surgery Cost-Effectiveness Research,"This study systematically reviewed all cost-effectiveness studies published on spine surgery, comparing and contrasting various costing methodologies used."
July 2014 ,BMC Anesthesiology,Intra-Aortic Balloon Pump During Extracorporeal Life Support,Does the use of an intra-aortic balloon pump during extracorporeal life support improve survival in patients with myocardial infarction and cardiogenic shock?
July 2014 ,Spine,Comparison of 2 Lumbar Total Disc Replacements,How do these two lumbar total disc replacement devices compare in regard to safety and outcome?
July 2014 ,Modern Pathology,Philadelphia Chromosome-Negative Myeloproliferative Neoplasms,This study tested the reproducibility of the histological parameters set out by the controversial WHO diagnostic classification for Philadelphia chromosome-negative myeloproliferative neoplasms.
July 2014 ,Endocrine Practice,Managing Radioactive Iodine-Refractory Thyroid Cancer,Which novel targeted therapies are effective for advanced differentiated thyroid cancer?
July 2014 ,Journal of Cardiovascular Electrophysiology,High-Risk Lead Removal by Laser Extraction and Thoracotomy,A new kind of hybrid procedure may be just right for pacemaker lead retrieval.
July 2014 ,BMC Ophthalmology,Visual Outcome of Mega-dose IV Corticosteroids in NAION,Is treatment with IV corticosteroids a safe and effective means of improving visual outcome in NAION patients?
July 2014 ,The American Journal of Gastroenterology,Poor Adherence to Guidelines for Chronic HBV Management,Does poor adherence to guidelines in the treatment and management of hepatitis B translate into poor patient outcomes?
July 2014 ,Pacing and Clinical Electrophysiology,Survival in Octogenarians Undergoing CRT vs General Population,Do elderly heart failure patients with biventricular pacemakers live longer than their non-paced peers?
July 2014 ,Southern Medical Journal,Hepatitis B in Pregnancy,"Each year, thousands of infants are born to women who are infected with the hepatitis B virus. How should the pregnant patient with HBV be managed?"
July 2014 ,Personalized Medicine,Recent Advances in Personalized Lung Cancer Medicine,Learn about genotype-directed targeted therapy for NSCLC.
July 2014 ,Cardiovascular Diabetology,Saxagliptin Improves Function of Pro-angiogenic Cells,Do DPP-4 inhibitors protect against cardiovascular disease? Read this to find out.
July 2014 ,European Heart Journal,Left Atrial Structure and Function in Atrial Fibrillation,"Learn more about the complex relationship between left atrial structure and function, electrical burden of atrial fibrillation and stroke risk."
July 2014 ,HIV Medicine,Pulmonary Abnormalities in HIV+ Patients Treated With ART,What are the risk factors for pulmonary abnormalities in HIV-positive patients?
July 2014 ,BMC Psychiatry,The Use of Global Positional Satellite Location in Dementia,"Getting lost outside is an all-too common occurrence for people with dementia, and often results in institutionalization. Might providing dementia patients with a GPS tracker help?"
July 2014 ,American Heart Journal,Adherence to Dabigatran and Longitudinal Outcomes,Find out more about adherence to dabigatran in the first year after initiation and the association between non-adherence to dabigatran and clinical outcomes.
July 2014 ,Menopause,Health of Women Beginning Postmenopausal Hormone Therapy,What are some of the reasons why women would take hormone therapy after menopause? This new study explains.
July 2014 ,Seminars in Respiratory and Critical Care Medicine,Rheumatoid Arthritis and Lung Disease: A Practical Approach,Common scenarios facing pulmonologists and rheumatologists are addressed using the current best evidence.
July 2014 ,Alcohol and Alcoholism,Cannabis as a Substitute Medication for Alcohol?,This study sought to determine whether cannabis satisfies previously published criteria for substitute medications. Should it be prescribed to alcohol-dependent individuals to help reduce drinking?
July 2014 ,Annals of Oncology,PCR After Neoadjuvant Chemo and Breast Cancer Subtypes,"What are the prognostic implications of pCR, TP53 status and treatment arm (taxane versus non-taxane) for intrinsic breast cancer subtypes?"
July 2014 ,Journal of the American Geriatrics Society,Thiazide-Induced Metabolic Adverse Events in Older Adults,"Thiazide diuretics are associated with several potentially severe metabolic adverse events, especially in the elderly. What should you know before prescribing these agents to older adults?"
July 2014 ,Liver International,A Pill for HCV -- Myth or Foreseeable Future?,"What all-oral, interferon-free therapies for hepatitis C are on the horizon?"
July 2014 ,BMC Endocrine Disorders,Efficacy and Safety of Canagliflozin in Older Patients,Are SGLT2 inhibitors safe in patients older than 65 years?
July 2014 ,The Journal of Emergency Medicine,Prednisone for Emergency Department Low Back Pain,The corticosteroid prednisone is commonly used to treat low back pain in the ED -- but how effective is it?
July 2014 ,Journal of the International Association of Providers of AIDS Care,Retention in HIV Care in Year 1: Who's In and Who's Out?,Which patients are less likely to be retained in HIV care?
July 2014 ,American Heart Journal,Antithrombotics in STEMI Patients Transferred for Primary PCI,Are patients with STEMI who are transferred for PCI at risk for delayed and/or excessively dosed antithrombotic therapy?
July 2014 ,Diabetes Care,T1DM Through the Life Span: ADA Position Statement,"From preconception counseling to pancreas transplantation, this statement from the ADA guides type 1 diabetes management for all patients."
July 2014 ,Current Opinion in Infectious Diseases,Novel Antibiotics for Skin and Soft Tissue Infection,Novel antibiotics are required because antibiotic resistance is a major global health hazard. This review examines recent antimicrobial developments.
July 2014 ,Journal of Pediatric Health Care,Current Guidelines for Weight Loss Surgery in Adolescents,What are the current clinical practice guidelines for weight loss surgery in adolescents?
July 2014 ,BMC Infectious Diseases,Probiotics for Pediatric Upper Respiratory Tract Infections?,"The role of probiotics in GI and allergic diseases has been largely assessed, but could probiotics be beneficial for pediatric respiratory infections as well?"
July 2014 ,Current Opinion in Rheumatology,Infection Risk and Biologics: Current Update,What is the risk of infection for a patient being treated with biologics?
July 2014 ,Liver International,Effect of Lifetime Alcohol Consumption on Severity of NAFLD,Does lifetime alcohol consumption predispose a patient to more severe forms of NAFLD? This new study explores the connection.
July 2014 ,Journal of the American College of Cardiology,Classifications of Atrial Fibrillation and Temporal Persistence,Find out how atrial fibrillation classification can be improved and how it may impact treatment.
July 2014 ,BMC Family Practice,Increasing Physical Activity by Organized Follow-Up,"Physical inactivity has been identified as the fourth leading risk factor for mortality, but getting patients to increase activity is challenging. Can a program of organized follow-up help?"
July 2014 ,Clinical Endocrinology,Growth Hormone in Adults With Growth Hormone Deficiency,"What are the long-term effects of growth hormone therapy on risk of cardiovascular disease, fractures, cancer, and stroke?"
July 2014 ,International Journal of Impotence Research,Reasons for Discontinuation of PDE-5 Inhibitors for ED,"Which ED patients are most likely to discontinue PDE5 therapy, and why? What can clinicians do to encourage compliance of this treatment?"
July 2014 ,Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health,US Exam for Underlying Lesions During Physical Exam,"How well do medical students perform this ultrasound-assisted physical exam, and can it play a role in the primary care setting?"
July 2014 ,Translational Lung Cancer Research,Immunotherapy in Lung Cancer,Immunotherapy has emerged in recent years as a promising therapeutic approach in lung cancer. Two approaches of particular interest are highlighted.
July 2014 ,BMC Public Health,Bullying Among Severely Obese Adolescents,"Obese adolescents are especially prone to being bullied, both traditionally and, increasingly, with cyberbullying. What impact does this have on their psychological well-being and treatment efforts?"
July 2014 ,Current Opinion in Gastroenterology,Therapy of IBD: What to Expect in the Next Decade,Read this new study to learn all about the exciting therapies on the horizon for the treatment of IBD.
July 2014 ,European Heart Journal,The Atrial Fibrillation Ablation Pilot Study,Find out how centers evaluate the success of the procedure and evaluate long-term safety/complications.
July 2014 ,Prostate Cancer and Prostatic Diseases,Novel Bone-Targeting Agents in Prostate Cancer,What are the newest bone-targeting agents for bone metastases in prostate cancer?
July 2014 ,BMC Oral Health,ART and Fluoride-Releasing Sealants in Caries Prevention,"Dental sealants are widely accepted as highly effective in preventing dental caries, but which type does a better job?"
July 2014 ,Nanomedicine,Delivery of Peptides for Anti-Tumor Immunotherapy,Could nanotechnology-based delivery of antigenic peptides be feasible for efficiently inducing anti-tumor cytotoxic T lymphocyte responses?
July 2014 ,AIDS,Locomotor Functions Over Time in HIV-Infected Patients,How does motor function over time in HIV+ individuals compare with healthy individuals?
July 2014 ,American Heart Journal,Alcohol Consumption and Systolic Ventricular Function,Does alcohol consumption impact LV systolic function?
July 2014 ,Urologic Nursing,Urinalysis Collection and Results in Pelvic Organ Prolapse,Learn best practice methods for a clean catch specimen in patients with pelvic organ prolapse.
July 2014 ,Current Opinion in Psychiatry,Polysubstance Use: Diagnostic Challenges and Patterns of Use,Individuals who abuse multiple substances are at elevated risk of developing comorbid psychiatric and other health conditions. Should they be approached differently than abusers of a single substance?
July 2014 ,Annals of Oncology,Anthracyclines and Taxanes in Breast Cancer Treatment,Is it optimal to give taxane before the anthracycline in breast cancer treatment?
July 2014 ,Future Oncology,Vintafolide: A Novel Targeted Epithelial Ovarian Cancer Agent,Get up-to-date on trial results for this novel folate receptor (FR)-targeted agent for epithelial ovarian cancer.
July 2014 ,Skin Therapy Letter,Xerese for the Treatment of Herpes Labialis,"What you need to know about Xerese, a topical combination acyclovir-hydrocortisone product for treating herpes labialis, commonly known as cold sores. What other therapies have proven effective?"
July 2014 ,Brain,Glucocerebrosidase Is Shaking Up the Synucleinopathies,"Recent progress in unraveling the mechanisms involving the enzyme glucocerebrosidase is not only advancing therapy for Gaucher disease, but may impact understanding of Parkinson's disease as well."
July 2014 ,Neurosurgical Focus,Management of Traumatic Thoracolumbar Burst Fractures,What's the level of evidence for the use of conservative management in traumatic thoracolumbar burst fractures?
July 2014 ,Oncology Nursing Forum,CBT for Insomnia After Primary Breast Cancer Treatment,Find out how nurse-delivered therapy impacts insomnia in women who have undergone breast cancer treatment.
July 2014 ,Morbidity & Mortality Weekly Report,Use of MenACWY-CRM Vaccine in Children Aged 2-23 Months,"MenACWY-CRM, the first quadrivalent meningococcal conjugate vaccine, is an additional option for vaccinating infants aged 2-23 months at increased risk for meningococcal disease."
July 2014 ,Nutrition and Metabolism,Systemic & Tumor Level Iron Regulation in Colorectal Cancer,How does hepcidin affect tumor iron accumulation in patients colorectal cancer?
July 2014 ,Alimentary Pharmacology & Therapeutics,Therapy of Chronic Delta Hepatitis With Peginterferon Alfa,How well does peg-interferon work as a long-term treatment for chronic delta hepatitis?