Adverse_Drug_Reaction_News_Headlines.csv

Date,Source,Headlines,Teaser
  February 2008 ,Medscape Medical News,Adverse Event Reporting for Cancer Therapy Needs Revision,"The Common Terminology Criteria for Adverse Events was developed to standardize language for reporting adverse events that occur in NCI-sponsored clinical trials, but it is unable to adequately code the subacute adverse events that occur with new targeted therapies."
  February 2008 ,Medscape Medical News,"Respiratory Compromise, Death May Be Linked to Botulinum Toxin","An ongoing FDA safety review of Botox, Botox Cosmetic (botulinum toxin type A), and Myobloc (botulinum toxin type B) has shown systemic adverse reactions resembling botulism."
  February 2008 ,Medscape Medical News,FDA Takes Action to Stop Marketing of Unapproved Colchicine Injection,"The US Food and Drug Administration has received 50 reports of adverse events with colchicine injection, including 23 deaths, related to product use."
  February 2008 ,Medscape Medical News,Two Studies Describe Approaches Shown to Reduce Obstetrical Errors,Yale teaching hospital cut its obstetrical error rate in half after implementing changes; a single change by a Pennsylvania hospital also showed improvement in patient safety.
  February 2008 ,Medscape Medical News,Varenicline May Be Linked to Risk for Serious Symptoms,"Patients given varenicline should be monitored for strange thoughts/behaviors, depressed mood, and suicidality."
  February 2008 ,Medscape Medical News,Antiepileptic Drugs Linked to Increased Risk for Suicidality,Patients taking certain drugs for epilepsy or other indications should be carefully monitored for behavioral changes.
  January 2008 ,Medscape Medical News,Heparin Recall,Nine lots of the antithrombin have been recalled because of a higher-than-expected rate of allergic reactions.
  September 2007 ,Medscape Medical News,Adverse Drug Events More Than Doubled Between 1998 and 2005,Serious adverse drug events reported to the US Food and Drug Administration's Adverse Event Reporting System increased 4 times faster than did the total number of outpatient prescriptions during this period.
  June 2007 ,Medscape Medical News,CF Patient Death May be Linked to Colistimethate Inhalation Therapy,"Inhalation solution should be used immediately to reduce the risk for pulmonary toxicity, according to the FDA."
  May 2005 ,Medscape Medical News,Isotretinoin May Decrease Depression in Adolescents With Acne,"Treatment of moderate-severe acne either with conservative therapy or with isotretinoin was associated with a decrease, not an increase, in depressive symptoms."
  January 2005 ,Medscape Medical News,"FDA Safety Labeling Changes: Vesanoid, Kaletra, Axid, Enbrel","The FDA has approved revisions to the safety labeling for tretinoin capsules (Vesanoid), lopinavir/ritonavir capsules and oral solution (Kaletra), nizatidine 75-mg tablets (Axid AR), and etanercept (Enbrel)."
  January 2005 ,Medscape Medical News,"Clozapine, Olanzapine May Increase Risk of Insulin Resistance","A cross sectional study suggests that compared with risperidone, use of these drugs is associated with a significantly higher risk of developing insulin resistance."
  July 2002 ,Medscape Medical News,Beta-Blockers May Be Underused,"No increase in depression risk was seen, but there was a small risk of fatigue and sexual dysfunction."
  June 2000 ,Medscape Medical News,Estrogen Replacement May Negate the Benefits of Growth Hormone,"In a preliminary study, researchers have found evidence that boosting production of growth hormone can reduce body fat and help maintain levels of functioning in elderly men and women."
  April 2008 ,Medscape Medical News,Rotigotine Patch Recalled Due to Drug Crystallization,Drug crystallization can hamper absorption; healthcare professionals are advised to begin down-titrating patients according to product guidelines and should not initiate rotigotine therapy in new patients.
  April 2008 ,Medscape Medical News,Rubber Chemical Found in Daptomycin Infusion Pumps,Healthcare professionals are advised to avoid the use of daptomycin with ReadyMED elastomeric infusion pumps.
  April 2008 ,Medscape Medical News,Exubera Gets Lung Cancer Warning,Cases occurred in prior smokers and are too few to establish a causal role for the product.
  April 2008 ,Medscape Medical News,Transparency in Adverse Event Reporting Pleases Patients,A new survey reveals that hospitalized patients are informed of less than half of all adverse events that they experience.
  April 2008 ,Medscape Medical News,Tegaserod Maleate Restricted to Emergency Use Only,FDA must approve requests for tegaserod maleate and must authorize shipments from the manufacturer.
  March 2008 ,Medscape Medical News,Study Data Link 2 NRTIs to Increased MI Risk,"The FDA recommends that healthcare professionals discuss potential risks and benefits of abacavir (Ziagen) and didanosine (Videx) therapy, including myocardial infarction, with HIV-infected patients."
  March 2008 ,Medscape Medical News,Diabetic Ulcer Gel Linked to Increased Cancer Deaths,Healthcare professionals are advised to discuss risks and benefits of becaplermin gel (Regranex) with patients.
  March 2008 ,Medscape Medical News,"Asthma Medication Evaluated for Possible Link to Mood Changes,  Suicidality",The FDA has issued a MedWatch Safety alert informing doctors and patients that it is investigating a possible link between use of montelukast and changes in mood and behavior as well as suicidality and suicide.
  March 2008 ,Heartwire from Medscape,More Heparin Recalls in Europe and US,"The latest countries to recall heparin products are France, Italy, and Denmark, and the affected material has been traced to four Chinese suppliers. Another US manufacturer has also recalled some heparin products."
  March 2008 ,Heartwire from Medscape,Heparin Contaminant Identified,The contaminant found in samples of heparin that had been linked to an increase in adverse reactions has now been identified as oversulfated chondroitin sulfate.
  March 2008 ,Medscape Medical News,Tiotropium Linked to Possible Increased Risk of Stroke,"On the basis of an ongoing safety review, MedWatch reports a possible increased risk of stroke with use of tiotropium."
  March 2008 ,Medscape Medical News,Serious Skin Reactions Reported With TNF-alpha Antagonists,"Safety reviews of infliximab, etanercept, and adalimumab identified rare cases of erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, and other skin reactions."
  March 2008 ,Medscape Medical News,Black Box Warning Issued for Etanercept Regarding Infections,A black box warning to be included on etanercept's prescribing information states that tuberculosis has been observed with TNF-blocking agents and that tuberculosis may be caused by reactivation of latent tuberculosis infection and by new infection.
  March 2008 ,Heartwire from Medscape,Heparin Contaminant Traced to China,The FDA has also issued an import alert requiring all heparin products be tested for the contaminant.
  March 2008 ,Medscape Medical News,New HIV Drug Linked to Risk for Hepatitis,Liver enzymes should be monitored during treatment with ritonavir-boosted darunavir.
  March 2008 ,Medscape Medical News,Cough Medicine Dosing Errors Linked to Patient Deaths,Patients should not take hydrocodone plus chlorpheniramine extended-release suspension (Tussionex) more often or at higher doses than recommended.
  March 2008 ,Heartwire from Medscape,Heparin Contaminant,"The FDA is requesting all heparin manufacturers to test products for this contaminant. Increased rates of adverse reactions have now also been reported in Germany with heparin not made by Baxter or its supplier, Scientific Protein Laboratories."
  March 2008 ,Medscape Medical News,What Your Patients Are Reading,"Hormone replacement therapy may result in a higher risk for breast cancer, both hysterectomy and uterine artery embolization can help treat uterine fibroids, tendonitis may be a result of statin use, obese children have more surgical complications than children of a normal weight, a change in selective serotonin reuptake inhibitors in conjunction with cognitive behavioral therapy may be adequate t"
  March 2008 ,Medscape Medical News,Antiviral Drug Labels Get Warnings for Neuropsychiatric Changes,Patients with influenza should be closely monitored for signs of abnormal behavior during treatment with Tamiflu and possibly also Relenza.
  February 2008 ,Medscape Medical News,Natalizumab May Cause Significant Liver Injury,Natalizumab (Tysabri) should be discontinued in patients with jaundice or other signs of liver injury.
  August 2008 ,Medscape Medical News,Byetta Linked to Acute Pancreatitis,Exenatide therapy has been linked to 6 new cases of hemorrhagic or necrotizing pancreatitis.
  August 2008 ,Medscape Medical News,FDA Warns About Injection Site Reactions With Naltrexone,"Injectable, extended-release naltrexone, used for the treatment of alcohol dependence, has been linked to adverse injection-site reactions, some requiring surgery."
  August 2008 ,Medscape Medical News,"HPV Vaccine Deemed Safe and Effective, Despite Reports of Adverse Events","Questions over the safety of the human papillomavirus vaccine have been raised by consumers, parents, healthcare professionals, and others. But having analyzed the available data, the CDC and FDA offer reassurance."
  August 2008 ,Medscape Medical News,FDA Releases List of Genomic Biomarkers Predictive of Drug Interactions,Quarterly updates of the table by the US Food and Drug Administration should help keep clinicians and patients informed about potential drug response and risk for adverse reactions.
  July 2008 ,Medscape Medical News,Genetic Screening Recommended Before Abacavir HIV Therapy,Screening for a particular allele can decrease the risk for abacavir hypersensitivity reactions by 60%.
  July 2008 ,Medscape Medical News,"Herceptin Vials to Be Checked for Damage, FDA Warns",Breakage and other damage may compromise sterility and pose infection risk to patient.
  July 2008 ,Medscape Medical News,"FDA Advisory Members Agree AEDs Pose Suicidality Risk, Nix Black Box","Antiepileptic drugs pose an increased risk of suicidality, but the data do not warrant a black-box warning, advisory committee members told the FDA."
  July 2008 ,Medscape Medical News,Fluoroquinolones Earn Black Box Warning for Tendon-Related Adverse Effects,The magnitude of reported adverse events related to fluoroquinolone use necessitates stronger warnings regarding the risk for tendonitis and tendon rupture.
  July 2008 ,Medscape Medical News,Local and National Legislation Banning Phthalates and BPA Considered,A bill has been introduced to Congress to prohibit the use of bisphenol A in all food and drink containers; the Senate is considering expanding the proposed ban to include toys and other children's products.
  July 2008 ,Medscape Medical News,Use of rhBMP in Cervical Fusion Linked to Serious Adverse Events,Healthcare providers should use approved alternative treatments or enroll in approved clinical trials.
  July 2008 ,Medscape Medical News,CellCept Labeling Changes Reflect PML Risk,Healthcare providers should include progressive multifocal leukoencephalopathy in the differential diagnosis of immunosuppressed patients presenting with focal neurologic symptoms.
  June 2008 ,Medscape Medical News,Probe of Erythropoiesis-Stimulating Agents,The preliminary work suggests that erythropoietin might have an effect not only on red blood cells but on tumor blood vessels as well. It is a provocative hypothesis that is generating fervent debate.
  June 2008 ,Medscape Medical News,Diabetic Ulcer Gel Gets Black Box Warning,An FDA safety review showed a 5-fold increased risk for cancer mortality in patients exposed to 3 or more tubes of becaplermin gel.
  June 2008 ,Heartwire from Medscape,Five Deaths in the UK Related to Rimonabant,"But only one of these deaths was due to psychiatric disorders (suicide), which is the major concern with this drug. Sanofi-Aventis has stressed that no causal link between any of the deaths and rimonabant has been established."
  June 2008 ,Medscape Medical News,FDA Investigates Link Between TNF Blockers and Pediatric Cancer,"Thirty cases of cancer have been reported in children and young adults receiving tumor necrosis factor blockers for arthritis, Crohn's disease, and other conditions."
  May 2008 ,Medscape Medical News,Transplant Drug Linked to Risk for Fetal Harm,"Women of childbearing age should be required to use 2 forms of birth control before, during, and after treatment with mycophenolate mofetil and mycophenolic acid."
  May 2008 ,Heartwire from Medscape,FDA Backpedals on Echo-Contrast Labeling,Warnings and contraindications imposed late last year have been softened after the agency heard from the medical community.
  May 2008 ,Medscape Medical News,Etanercept Gets Black Box Warning for TB Risk,Patients should be both screened for latent tuberculosis before initiation of etanercept therapy and monitored for infection during and after treatment.
  April 2008 ,Medscape Medical News,Enoxaparin Contaminant,"Some countries have recalled affected batches, although no increase in adverse reactions has been seen."
  April 2008 ,Medscape Medical News,Anticholinergic Drugs May Increase Cognitive Decline,A new study finds that use of drugs with anticholinergic activity is associated with a more rapid decline in cognitive performance.
  November 2008 ,WebMD Health News,Panel: Toughen Dermal Filler Warnings,An FDA panel wants stronger warning labels on dermal fillers like Restylane and Juvederm injected into the face for wrinkles.
  November 2008 ,Medscape Medical News,Bevacizumab Significantly Increases VTE Risk,"The risk of venous thromboembolism was increased by 33%, compared with controls, concludes a new meta-analysis of 15 cancer trials."
  November 2008 ,Medscape Medical News,"No Link Between Bisphosphonates and Atrial Fibrillation, FDA Says",The agency is advising healthcare professionals not to alter their prescribing patterns for bisphosphonate therapy.
  November 2008 ,Medscape Medical News,Five Generic Ethex Products Recalled Because of Overdose Risk,Oversize tablets may contain up to double the amounts of the active ingredient.
  October 2008 ,Medscape Medical News,Rimonabant Suspended in Europe,"European regulators say rimonabant's benefits no longer outweigh its risks. Its manufacturer, however, says it remains committed to the drug and hopes to provide evidence to support its reevaluation in the future."
  October 2008 ,Medscape Medical News,Postmarketing Surveillance for Biologic Agents,"Biologics are a rapidly growing class of drugs, but many of their associated safety problems are not identified until after receiving approval from regulatory agencies."
  October 2008 ,Medscape Medical News,Boxed Warning Highlights Risk for Infection With Raptiva,Postmarketing reports indicate an increased risk for opportunistic infections in patients receiving efalizumab injection.
  October 2008 ,Medscape Medical News,Preliminary Data Suggest Spiriva Not Linked to Increased Stroke Risk,Findings contradict recently published findings that tiotropium bromide increases the risk for mortality and/or cardiovascular events.
  September 2008 ,Medscape Medical News,High-Dose Epogen/Procrit Linked to Deaths,Adverse events in other epoetin-alfa clinical trials should be monitored to ensure that the potential benefits outweigh the risks to patients.
  September 2008 ,Medscape Medical News,Tarceva Linked to 2 Fatal Cases of Hepatotoxicity,Patients with hepatic impairment should be closely monitored during treatment with erlotinib.
  September 2008 ,Medscape Medical News,Particulate Matter Found in Ammonul Injection,Filters must be used during the admixture process because particulate matter may not be visible to the naked eye.
  September 2008 ,Medscape Medical News,"Company, Investigator Disagree on Reporting of Epoetin Alfa Trial","Ortho Biotech announced that preliminary data from a trial of epoetin alfa in stroke patients show higher mortality among treated patients than those on placebo and that it had informed the FDA. The lead investigator of the trial, though, says the statement is inaccurate as it stands and that the increase in mortality was limited to patients who received both tissue plasminogen activator and epoet"
  September 2008 ,Medscape Medical News,Phosphocol Linked to Risks for Malignancy and Radiation Injury,Postmarketing cases of lymphocytic leukemia have been reported with intra-articular use; intraperintoneal use has been linked to local necrosis and fibrosis.
  September 2008 ,Medscape Medical News,Rituxan Linked to Fatal PML Case,Clinicians are advised to consider progressive multifocal leukoencephalopathy in rituximab-treated patients presenting with new-onset neurologic manifestations.
  September 2008 ,WebMD Health News,20 Drugs the FDA Is Watching,The first new quarterly report identifies adverse drug effects that are under FDA investigation.
  September 2008 ,Medscape Medical News,Patient Deaths Spark Stronger Warnings for TNF Blockers,Patients should be monitored for signs and symptoms of fungal infection both during and after therapy.
  August 2008 ,Medscape Medical News,Effects of Sunitinib in Renal Cell Cancer Patients,Researchers describe adverse dermatologic effects in the scrotal and inguinal areas in 5 of 40 patients taking sunitinib for renal cell carcinoma.
  August 2008 ,WebMD Health News,"Cialis, Viagra Labels to Note Amnesia",Rare reports of transient global amnesia have been added to the Cialis and Viagra labels; the condition is already on the Levitra label.
  August 2008 ,Medscape Medical News,New PML Cases Reported With Tysabri Monotherapy,Natalizumab monotherapy is still believed to be safer than combination treatment with other immunomodulatory agents.
  August 2008 ,Medscape Medical News,Taxanes Increase Risk for Psychologic Symptoms,Patients who receive taxane-based chemotherapy have delayed emotional recovery and a higher rate of probable clinical depression than patients on similar regimens without taxanes.
  January 2009 ,Medscape Medical News,"FDA Safety Changes: Norditropin, Rozerem, Zomig","The FDA has approved revisions to the safety labeling for somatropin [rDNA origin] injection (Norditropin), ramelteon (Rozerem), and zolmitriptan (Zomig)."
  January 2009 ,Medscape Medical News,"FDA Safety Changes: Apidra, Ontak, Raptiva","The FDA has approved revisions to the safety labeling for insulin glulisine [rDNA origin] injection (Apidra), denileukin diftitox (Ontak), and efalizumab (Raptiva)."
  December 2008 ,Medscape Medical News,"FDA Safety Changes: Celexa, Erbitux, ACE Inhibitors","The FDA has approved revisions to the safety labeling for citalopram HBr tablets and oral solution, cetuximab intravenous infusion, and certain angiotensin-converting enzyme inhibitors."
  January 2009 ,Medscape Medical News,"FDA Safety Changes: Clolar, Precedex, Treanda","The FDA has approved revisions to the safety labeling for clofarabine injection (Clolar), dexmedetomidine HCl injection (Precedex), and bendamustine HCl injection (Treanda)."
  January 2009 ,Medscape Medical News,FDA Warns That Tinzaparin Increases Mortality Risk in Elderly Patients,A clinical study indicated that tinzaparin may lead to an increased risk for death in all renal-impaired elderly patients receiving tinzaparin.
  December 2008 ,Medscape Medical News,Prolonged Empiric Antibiotics May Increase Risk for NEC in Certain Infants,"In extremely-low-birth-weight infants, prolonged initial empiric antibiotics should be used with caution because they may be associated with an increased risk for necrotizing enterocolitis or death."
  December 2008 ,Medscape Medical News,AES 2008: Valproate Should Not Be Used in Women Who May Become Pregnant,Investigators say clinicians should rethink their use of valproate in women in what some researchers are calling a practice-altering finding.
  December 2008 ,Medscape Medical News,Elderly Often Use Prescription and Nonprescription Medications Together,A study of community-dwelling older adults showed that nearly 1 in 25 individuals were potentially at risk for a major drug-drug interaction.
  December 2008 ,Heartwire from Medscape,FDA and Diabetes Drugs,The recommendation that diabetes drugs must show cardiovascular safety is included in a new guidance document issued this week by the agency and emerges after concerns have been raised about drugs in this field. More than 100 letters have been sent to drug companies informing them of the new recommendations.
  December 2008 ,Medscape Medical News,FDA Requires Warnings About Suicidality Risk With Antiepileptic Drugs,The US Food and Drug Administration will require the manufacturers of antiepileptic drugs to add a warning to their labeling that use of the drugs increases risk for suicidal thoughts and behaviors.
  December 2008 ,Medscape Medical News,New Case of PML with Natalizumab Monotherapy,"Biogen Idec and Elan reported to the SEC that another case of PML has been seen with natalizumab therapy in a patient with MS. The case was found through surveillance, the companies note, and the patient is stable."
  December 2008 ,Medscape Medical News,Adverse Event Reporting Systems May Need Improvement,A national survey evaluated the present status of US hospital-based adverse event reporting systems and suggested needed improvements in reporting processes.
  December 2008 ,Medscape Medical News,Oral Sodium Phosphate Products Linked to Acute Phosphate Nephropathy,The use of oral sodium phosphate products has been tied to acute phosphate nephropathy.
  December 2008 ,WebMD Health News,FDA Panel Urges Restrictions on 2 Asthma Drugs,Experts urged the FDA to communicate to doctors that Serevent and Foradil inhalers should not be used alone.
  December 2008 ,WebMD Health News,FDA Panel Asks: Are Asthma Drugs Safe?,"Serevent, Symbicort, and Foradil are the focus of a triple FDA panel meeting investigating their safety."
  December 2008 ,Medscape Medical News,Panel Disputes FDA Finding on Antiepileptics and Risk for Suicide,"The methodology of meta-analysis is flawed, a panel says, and the decision will have unfortunate consequences for patients and the future of AED clinical trials."
  December 2008 ,Heartwire from Medscape,CDC Provides Details on Heparin Investigation,"A new paper tells the story of how the CDC, after identifying oversulfated chondroitin as the plausible culprit contaminant, linked products containing the contaminant to the clinical symptoms of patients treated across 21 facilities in 13 states."
  November 2008 ,Medscape Medical News,More Research Urgently Needed on Off-Label Use of 14 Drugs,A quantitative analysis identified particular concerns regarding safety of off-label use of antipsychotic and antidepressant drugs.
  November 2008 ,Medscape Medical News,FDA Investigates Genetic Link to Phenytoin Skin Reactions,Clinicians should avoid the antiepileptic drugs phenytoin and fosphenytoin as alternatives to carbamazepine therapy in patients positive for the HLA-B*1502 allele.
  November 2008 ,Heartwire from Medscape,"Higher Mortality, CHF With Rosiglitazone","A retrospective analysis of Medicare beneficiaries found all-cause mortality to be increased by 15% in patients taking rosiglitazone, while congestive heart failure hospitalizations were 13% higher. Stroke and MI, however, were no different between the treatment groups."
  February 2009 ,Medscape Medical News,Boxed Warning Added to Metoclopramide-Containing Drugs,The FDA says that a boxed warning about the risk for tardive dyskinesia during long-term or high-dose use must be added to the drug labels of metoclopramide-containing drugs.
  February 2009 ,Medscape Medical News,More Caution Needed for Warfarin Use in Chronic Kidney Disease,A prospective study suggests that warfarin may need to be started at a lower dosage and monitored more closely in patients with moderate or severe chronic kidney disease vs the general population.
  February 2009 ,Medscape Medical News,Antiepileptic Drug Linked to Metabolic Acidosis,"The FDA recommends that healthcare professionals measure serum bicarbonate before initiating therapy and during treatment with zonisamide (Zonegran), even when symptoms are absent."
  February 2009 ,Medscape Medical News,Drug Linked to Deaths From Progressive Multifocal Leukoencephalopathy,"Three deaths from PML and a possible fourth case have been reported in patients taking the immunosuppressant drug efalizumab, according to the FDA."
  February 2009 ,Medscape Medical News,Certain Skin-Related Adverse Drug Events May Have Genetic Basis,"In the first initial data released by the Food and Drug Administration in conjunction with the International Serious Adverse Events Consortium, the genetics associated with drug-induced serious skin rashes, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, are described. The data are expected to help better predict an individual's risk of developing these reactions."
  February 2009 ,Medscape Medical News,Long-Term Use of Popular Inhalers May Increase Risk for Pneumonia in COPD,Inhaled corticosteroid use for at least 24 weeks in patients with chronic obstructive pulmonary disease was associated with a significantly increased risk for serious pneumonia but not for death.
  February 2009 ,Medscape Medical News,"FDA Safety Changes: Promethazine and Codeine Oral Solution, Ranexa, Ethyol","The FDA has approved revisions to the safety labeling for promethazine HCl and codeine phosphate oral solution, ranolazine extended-release tablets, and amifostine injection."
  February 2009 ,Medscape Medical News,"FDA Safety Changes: Selzentry, Triglide, Neulasta","The FDA has approved revisions to the safety labeling for maraviroc tablets, fenofibrate tablets, and pegfilgrastim."
  February 2009 ,Medscape Medical News,FDA Continues to Investigate Bleeding Risk for Xigris,"The Food and Drug Administration announced today that is continuing to evaluate the incidence of serious bleeding events and death in patients who receive drotrecogin alfa activated, a recombinant human activated protein C indicated for the treatment of severe sepsis."
  January 2009 ,Heartwire from Medscape,Clopidogrel and PPIs,"The findings support suspicions that the drug combination diminishes the beneficial effect of the antiplatelet therapy and increases the risk of future events, say researchers."
  January 2009 ,Heartwire from Medscape,Generics Manufacturer Suspends More Than 100 Products,"A unit of KV Pharmaceutical has stopped manufacturing and selling more than 100 products, including antianginal nitrates and calcium-channel blockers."
  January 2009 ,Medscape Medical News,FDA Safety Changes: Cordarone and Exjade,The FDA has approved revisions to the safety labeling for amiodarone HCl tablets and deferasirox tablets for oral suspension.
  January 2009 ,Medscape Medical News,Loop Diuretic Use Linked to Higher Fracture Risk in Postmenopausal Women,"After adjustment for confounding variables, a study shows no significant association between ever-use of loop diuretics and changes in bone mineral density, falls, and fractures."
  January 2009 ,Heartwire from Medscape,COGENT 1 Scrapped; Sponsor Bankrupt,The trial was testing a single-pill combination of clopidogrel and omeprazole to reduce the incidence of GI side effects.
  January 2009 ,Medscape Medical News,"FDA Safety Changes: Prevacid NapraPAC 500, Prezista, Arixtra","The FDA has approved revisions to the safety labeling for lansoprazole delayed-release capsules and naproxen tablet kit, darunavir tablets, and fondaparinux sodium injection."
  January 2009 ,Medscape Medical News,FDA Safety Changes: Atrovent and Atripla,The FDA has approved revisions to the safety labeling for ipratropium Br nasal spray (Atrovent) and for efavirenz/emtricitabine/tenofovir disoproxil fumarate tablets (Atripla).
  January 2009 ,Medscape Medical News,Tainted Weight Loss Drugs,"The expanded list ups the number of contaminated products from 28 to 69. Many of these ""natural"" or ""herbal"" products contained sibutramine, phenolphthalein, and even rimonabant."
  January 2009 ,Heartwire from Medscape,WSJ on Rosiglitazone,A report by the Wall Street Journal reveals that GlaxoSmithKline had similar concerns about rosiglitazone as the researchers who first raised alarms about the diabetes drug.
  January 2009 ,Heartwire from Medscape,FDA Pilot Program,"The FDA is to launch a pilot program to help promote the safety of drugs and active pharmaceutical ingredients produced outside the US, with around 100 voluntary applicants to be selected for participation."
  January 2009 ,Heartwire from Medscape,Sidney Wolfe Joins FDA Safety Committee: WSJ,"Dr Sidney Wolfe was appointed to the FDA Safety and Risk Managemnet Committee in August 2008, according to the WSJ."
  April 2009 ,Medscape Medical News,Online System May Help Identify Patterns of Adverse Surgical Events,"A study suggests that a user-friendly, Web-based system to track morbidity, mortality, and near-misses should be used by surgery departments to identify quality improvement opportunities."
  April 2009 ,Medscape Medical News,Zoledronic Acid Infusion Effective for Bone Loss Linked With Glucocorticoid Use,"In a randomized trial, a single 5-mg intravenous infusion of zoledronic acid was more acceptable to patients vs 5 mg of oral risedronate daily to prevent and treat glucocorticoid-related bone loss."
  April 2009 ,Medscape Medical News,Tadalafil or Sildenafil Not Linked to Visual Effects With 6 Months of Daily Use,"In a randomized trial of medications for erectile dysfunction, no abnormalities in electroretinography or visual function and no treatment-related findings suggestive of drug toxicity were observed."
  April 2009 ,Medscape Medical News,"FDA Safety Changes: Toprol XL, Revlimid, Fludara","The FDA has approved safety labeling revisions for metoprolol succinate extended-release tablets (Toprol-XL), lenalidomide (Revlimid), and fludarabine phosphate intravenous infusion (Fludara)."
  April 2009 ,Medscape Medical News,Combined Oral Contraceptive Use Linked to Risk for Systemic Lupus Erythematosus,"Ceftriaxone can now be administered concomitantly with calcium-containing products in patients older than 28 days, updating a previous recommendation contraindicating this combination in all age groups."
  April 2009 ,Medscape Medical News,Ceftriaxone Can Be Administered With Calcium-Containing Products in Certain Patients,The new labeling changes for lopinavir/ritonavir include warnings and precautions regarding QT/QTC interval and PR interval prolongation.
  April 2009 ,Medscape Medical News,FDA Issues Safety Labeling Changes for Kaletra ,"FDA Safety Changes: Luvox/Luvox CR, Altace, Capozide, Monopril/Monopril HCT, Furadantin"
  April 2009 ,Medscape Medical News,"FDA Safety Changes: Luvox/Luvox CR, Altace, Capozide, Monopril/Monopril HCT, Furadantin","The agency said that saxagliptin does not pose a cardiovascular risk to diabetes patients, effectively recommending the drug for approval, while liraglutide was turned away by the advisory panel because of an increased risk of cancer observed in animal studies. "
  April 2009 ,Heartwire from Medscape,"Saxagliptin Gets Favorable FDA Panel Review, While Liragutide Not Recommended for Approval","The FDA has approved revisions to the safety labeling for bosentan tablets, esomeprazole injection, esomeprazole magnesium delayed-release capsules and oral suspension, and tigecycline injection."
  April 2009 ,Medscape Medical News,"FDA Safety Changes: Tracleer, Nexium, Nexium IV, Tygacil ","Over a four-year period, the rates of cancer-associated adverse events and the proportion of all reported adverse events related to cancer were less than event rates observed with other potent cholesterol-lowering medications."
  March 2009 ,Heartwire from Medscape,FDA Postmarketing Surveillance Data Show No Cancer Risk With Ezetimibe,"The FDA has approved revisions to the safety labeling for various selective serotonin and serotonin-norepinephrine reuptake inhibitors; multiple electrolytes injection, type 1; and telbivudine."
  March 2009 ,Medscape Medical News,"FDA Safety Changes: Antidepressants, Plasma-Lyte 148, Tyzeka","Watson Pharmaceuticals has recalled one lot of propafenone HCl 250 mg packed in 100-count bottles it said was shipped to customers between October 15, 2008 and November 26, 2008."
  March 2009 ,Heartwire from Medscape,Watson Pharma Recalls One Lot of Propafenone 225 mg,Insulin pens and cartridges should not be used in multiple patients because of the risk for transmission of blood-borne pathogens.
  March 2009 ,Medscape Medical News,"FDA Warns Against Sharing Single-Use Insulin Pens, Cartridges","The FDA has approved revisions to the safety labeling for hydrocodone bitartrate and homatropine methylbromide, benazepril, benazepril plus hydrochlorothiazide, and cefdinir."
  March 2009 ,Medscape Medical News,"FDA Safety Changes: Hycodan, Lotensin, Lotensin HCT, Omnicef","The FDA has approved revisions to the safety labeling for celecoxib capsules (Celebrex), indinavir sulfate tablets (Crixivan), and isoniazid plus pyrazinamide and rifampin tablets (Rifater)."
  March 2009 ,Medscape Medical News,"FDA Safety Changes: Celebrex, Crixivan, Rifater","The FDA has approved revisions to the safety labeling for anastrozole tablets (Arimidex), carvedilol tablets and extended-release tablets (Coreg, Coreg CR), and alglucosidase alfa injection (Myozyme)."
  March 2009 ,Medscape Medical News,"FDA Safety Changes: Arimidex, Coreg/Coreg CR, Myozyme",A study shows that antibiotic use in the first year of life is linked to a small risk for the development of asthma and that the risk increases with the number of courses of antibiotics prescribed.
  March 2009 ,Medscape Medical News,Antibiotic Use in First Year of Life Linked to Risk of Developing Asthma,Certain transdermal patches containing even small traces of aluminum or other metals in the adhesive backing can cause skin burns if worn during magnetic resonance imaging.
  March 2009 ,Medscape Medical News,"Medicated Patch Can Cause Burns During MRI, FDA Warns","The FDA has approved revisions to the safety labeling for ipratropium bromide and albuterol sulfate inhalation aerosol, quinine sulfate capsules, and sacrosidase oral solution."
  June 2009 ,Medscape Medical News,FDA Safety Changes: Exjade and Extraneal,The FDA has approved safety labeling revisions for deferasirox tablets for oral suspension (Exjade) and icodextrin peritoneal dialysis solution (Extraneal).
  June 2009 ,Medscape Medical News,"Propylthiouracil Linked With Risk for Serious Liver Damage, Death","The FDA has issued a safety alert about the risk for serious liver damage, including liver failure, or death with propylthiouracil compared with methimazole."
  June 2009 ,Medscape Medical News,Proton-Pump Inhibitors Increase Risk for Hospital-Acquired Pneumonia,"In a large, prospective, hospital-based pharmacoepidemiologic cohort, acid suppressive medication use was associated with 30% increased odds of hospital-acquired pneumonia."
  June 2009 ,Medscape Medical News,FDA Safety Changes: Remicade and Doribax,The FDA has approved safety labeling revisions for infliximab intravenous infusion (Remicade) and doripenem intravenous infusion (Doribax).
  May 2009 ,Medscape Medical News,"FDA Safety Changes: Advair Diskus, Orap, Rocephin","The FDA has approved safety labeling revisions for fluticasone propionate and salmeterol xinafoate inhalation powder, pimozide tablets, and ceftriaxone sodium injection."
  May 2009 ,WebMD Health News,Cancer Drug Erases Man's Fingerprints,A traveler was temporarily denied entry into the U.S. because of a side effect of Xeloda.
  May 2009 ,Medscape Medical News,Postdischarge Adverse Events Are Common,"The timing and type of follow-up of older discharged patients might need to change, according to a new study."
  May 2009 ,Medscape Medical News,Cholinesterase Inhibitors Linked to Serious Adverse Events in Older Adults With Dementia,"A population-based cohort study suggests that the risks for syncope, bradycardia, pacemaker insertion, and hip fracture must be weighed carefully against the generally modest benefits of cholinesterase inhibitors."
  May 2009 ,Medscape Medical News,Tamsulosin Use Linked to Serious Ophthalmic Adverse Events After Cataract Surgery,"Use of tamsulosin within 14 days of cataract surgery, but not of other alpha-blocker medications used to treat benign prostatic hyperplasia, was significantly associated with serious postoperative ophthalmic adverse events."
  May 2009 ,Medscape Medical News,"FDA Safety Changes: Zithromax, Frova, Lexiscan","The FDA has approved safety labeling revisions for azithromycin tablets and oral suspension (Zithromax), frovatriptan succinate tablets (Frova), and regadenoson injection (Lexiscan)."
  May 2009 ,Heartwire from Medscape,Merck Defense Begins in Oz,Lawyers for Merck began their defense this week in the rofecoxib class-action lawsuit that is ongoing in Australia. They will have to counter many astonishing allegations that have been made in court in Melbourne over the past few weeks.
  May 2009 ,Medscape Medical News,"FDA Safety Changes: Visicol, OsmoPrep, DiaBeta, Raptiva","The FDA has approved safety labeling revisions for sodium phosphate monobasic monohydrate and sodium phosphate dibasic anhydrous tablets (Visicol and OsmoPrep), glyburide tablets (DiaBeta), and efalizumab subcutaneous injection (Raptiva)."
  May 2009 ,Medscape Medical News,"FDA Safety Changes: Axert, Tarka, Macrobid, Macrodantin","The FDA has approved safety labeling revisions for almotriptan malate tablets (Axert), verapamil HCl/trandolapril tablets (Tarka), and nitrofurantoin monohydrate/macrocrystals capsules (Macrobid and Macrodantin)."
  May 2009 ,WebMD Health News,Hydroxycut Recall Due to Liver Injuries,FDA says people should stop using the diet products immediately.
  May 2009 ,Reuters Health Information,Antibiotic Use in Childhood Not Linked to Type 1 Diabetes,"Contrary to what several other studies have shown, the results of a nationwide study of Danish children suggest that antibiotic use does not affect the development of type 1 diabetes."
  April 2009 ,Medscape Medical News,FDA Safety Changes: Sporanox and Novothyrox,The FDA has approved safety labeling revisions for itraconazole (Sporanox) and levothyroxine sodium tablets (Novothyrox).
  April 2009 ,Medscape Medical News,"FDA Safety Changes: Epzicom, Trizivir, Tracleer","The FDA has approved safety labeling revisions for abacavir sulfate and lamivudine tablets (Epzicom), abacavir plus lamivudine and zidovudine tablets (Trizivir), and bosentan tablets (Tracleer)."
  April 2009 ,Medscape Medical News,New Electronic Medication Intervention Appears to Decrease Potential Adverse Drug Events,A computerized medication reconciliation tool and process redesign was associated with a decrease in unintentional medication discrepancies with potential for patient harm.
  April 2009 ,Medscape Medical News,"FDA Safety Changes: Zantac, Zithromax, Noxafil"," The FDA has approved safety labeling revisions for ranitidine HCl, azithromycin, and posaconazole."
  April 2009 ,Medscape Medical News,"FDA Safety Changes: Comtan, Stalevo, Tasmar, Symmetrel, Xenical, Casodex","The FDA has approved safety labeling revisions for entacapone tablets, levodopa/carbidopa/entacapone tablets, tolcapone tablets, amantadine HCl syrup and tablets, orlistat, and bicalutamide."
  August 2009 ,Medscape Medical News,"FDA Safety Changes: Chantix, DiaBeta, Aralen","The FDA has approved safety labeling revisions for varenicline tartrate tablets (Chantix), glyburide tablets (DiaBeta), and chloroquine phosphate tablets (Aralen)."
  August 2009 ,Medscape Medical News,"FDA Safety Changes: Strattera, Aptivus, CellCept","The FDA has approved safety labeling revisions for atomoxetine HCl capsules; tipranavir capsules and oral solution; and mycophenolate mofetil capsules, tablets, injection, and oral suspension."
  August 2009 ,Medscape Medical News,FDA Updates Warnings for TNF Blockers and Cancer Risk,The FDA is requiring stronger warnings regarding the risk for cancer associated with tumor necrosis factor blockers.
  July 2009 ,Medscape Medical News,"FDA Safety Changes: Rocephin, Amaryl, Prandin","The FDA has approved safety labeling revisions for ceftriaxone sodium injection (Rocephin), glimepiride tablets (Amaryl), and repaglinide tablets (Prandin)."
  July 2009 ,Medscape Medical News,"FDA Safety Changes: Aristospan, Videx/Videx EC, Coreg/Coreg ER","The FDA has approved safety labeling revisions for triamcinolone hexacetonide, didanosine oral solution and delayed-release capsules, carvedilol tablets, and carvedilol extended-release tablets."
  July 2009 ,Medscape Medical News,Benefits of Intensive Methotrexate Treatment Outweigh Adverse Events in Early Rheumatoid Arthritis,A study of methotrexate in patients with rheumatoid arthritis shows a higher occurrence of adverse events but better clinical efficacy with intensive treatment vs conventional treatment with the drug.
  July 2009 ,Medscape Medical News,"Methylphenidate, Amphetamines Show Cardiac Risks in Children With ADHD","In a retrospective study, use of methylphenidate and amphetamines shows a similar risk for cardiac emergency department visits in children and adolescents with attention-deficit/hyperactivity disorder."
  July 2009 ,Medscape Medical News,Omalizumab May Be Linked to Cardiovascular Adverse Events,Results of an interim analysis suggest that omalizumab (Xolair) may be associated with a disproportionate increase in the incidence of certain cardiovascular adverse events.
  July 2009 ,Medscape Medical News,FDA Safety Changes: Reglan and Prometrium,"The FDA has approved safety labeling revisions for metoclopramide tablets, orally disintegrating tablets, and injection (Reglan); and progesterone capsules (Prometrium)."
  July 2009 ,Medscape Medical News,"Drug-Induced Acute Liver Failure Very Rare, but Can Be Fatal","A study shows that acetaminophen is the most common cause of drug-induced acute liver failure, accounting for nearly half of cases in adults, but other drugs can also be responsible."
  July 2009 ,Medscape Medical News,Methylphenidate Well Tolerated by Childhood Cancer Survivors,"In childhood cancer survivors, overall tolerability of methylphenidate was good, but a subgroup was at increased risk for adverse effects that may need close monitoring or prescription of a lower dose."
  July 2009 ,Medscape Medical News,"Famotidine Prevents Peptic Ulcers, Esophagitis in Patients Taking Aspirin","Famotidine is effective in preventing gastric and duodenal ulcers, and erosive esophagitis in patients taking low-dose aspirin for vascular protection, a phase 3 study reveals."
  July 2009 ,Medscape Medical News,Ketamine May Be Useful for Intubation in Critically Ill Patients,"A randomized controlled, single-blind trial shows that ketamine is a safe, valuable alternative to conventional etomidate to use as a sedative during intubation in critically ill patients."
  July 2009 ,Medscape Medical News,Insulin Glargine Potentially Associated With Increased Cancer Risk ,"The increased risk has been seen in 3 of 4 observational studies, but these findings warrant further follow-up studies to confirm an association, according to the FDA."
  July 2009 ,Medscape Medical News,Chantix and Zyban to Receive Boxed Warnings for Serious Neuropsychiatric Symptoms,"Varenicline and bupropion are receiving boxed warnings regarding the risks for changes in behavior, hostility, agitation, depressed mood, suicidal thoughts and behavior, and attempted suicide."
  July 2009 ,Medscape Medical News,"FDA Safety Changes: Prevpac, Arava, Treanda","The FDA has approved safety labeling revisions for a prepackaged regimen of lansoprazole, amoxicillin, and clarithromycin tablets; leflunomide tablets; and bendamustine HCl intravenous infusion."
  June 2009 ,Medscape Medical News,Contrast-Induced Nephropathy May Be Linked to Long-Term Adverse Events,"After adjustment for baseline comorbidities and risk factors, the  incidence rate ratio for adverse events was twice as high in those with CIN defined stringently."
  June 2009 ,Medscape Medical News,"FDA Safety Changes: Kerlone, Meridia, Stromectol","The FDA has approved safety labeling revisions for betaxolol HCl tablets (Kerlone), sibutramine HCl monohydrate capsules (Meridia), and ivermectin tablets (Stromectol)."
  June 2009 ,Medscape Medical News,"FDA Safety Changes: Minipress, Letairis, Coly-Mycin M Parenteral","The FDA has approved safety labeling revisions for prazosin HCl capsules (Minipress), ambrisentan tablets (Letairis), and colistimethate injection (Coly-Mycin M Parenteral)."
  June 2009 ,Medscape Medical News,"FDA Safety Changes: Sarafem, Mavik, Cordarone","The FDA has approved safety labeling revisions for deferasirox tablets for fluoxetine HCl (Sarafem tablets), trandolapril (Mavik tablets), and amiodarone HCl (Cordarone tablets)."
  October 2009 ,Medscape Medical News,Neuron 070 Delivery Catheters Recalled Due to Kinking,Delivery catheters are being voluntarily recalled by their manufacturer because of kinking and/or ovalization of the catheter lumen; 4 injuries possibly associated with this defect have been reported.
  September 2009 ,Medscape Medical News,FDA Issues Risk Communication Plan for Providing Public Health Information ,A new FDA plan issued today outlines how information on FDA-regulated products will be disseminated to the public.
  September 2009 ,Medscape Medical News,"FDA Safety Changes: Zyprexa, Geodon, Lariam, Merrem IV, Primaxin","The FDA has approved safety labeling revisions for olanzapine, ziprasidone, mefloquine HCl tablets, meropenem, and imipenem/cilastatin."
  September 2009 ,Heartwire from Medscape,New Study Helps to Characterize Heparin-Induced Skin Lesions,"A new prospective study has found the incidence of heparin-induced skin lesions to be around 7.5%. Women, the obese, and those on heparin therapy for longest are most at risk."
  September 2009 ,Medscape Medical News,Hormone Replacement Therapy Linked to Risk for Death From Lung Cancer,"In an analysis of data from the Women's Health Initiative, hormone replacement therapy with use of estrogen and progestin was associated with increased risk for death from lung cancer."
  September 2009 ,Medscape Medical News,Septic Shock from Surgical Mesh for Pelvic Organ Prolapse ,The case of a 61-year old woman presenting with septic shock 6 weeks after transvaginal placement of polypropylene mesh for pelvic organ prolapse highlights problems with FDA notification.
  September 2009 ,Medscape Medical News,FDA Issues Early Communication Regarding Deferasirox Safety in MDS,"Patients receiving deferasirox who have myelodysplastic syndrome may be at greater risk for adverse events such as kidney failure, gastrointestinal hemorrhage, and fatalities."
  September 2009 ,Medscape Medical News,"Sitagliptin Linked to Acute Pancreatitis, FDA Warns","The FDA is revising prescribing information for sitagliptin (Januvia) and sitagliptin/metformin (Janumet) after cases of acute pancreatitis, some severe, surfaced in postmarketing reports."
  September 2009 ,Medscape Medical News,Potential Dosing Errors With Oseltamivir in Children,"US clinicians usually prescribe liquid medicines in milliliters (mL) or teaspoons, but Tamiflu is dosed in milligrams (mg), and the dispenser is marked only in 30, 45, and 60 mg."
  September 2009 ,Medscape Medical News,Natalizumab Associated With Ongoing Cases of PML,"Rare but ongoing cases of PML continue to be associated with the use of natalizumab, according to the FDA."
  September 2009 ,Medscape Medical News,"FDA Safety Changes: Metronidazole Injection, DexFerrum, INFeD, Tasigna","The FDA has approved safety labeling revisions for metronidazole injection, iron dextran injection (DexFerrum and INFeD), and nilotinib HCl monohydrate capsules (Tasigna)."
  September 2009 ,Medscape Medical News,FDA Adds Boxed Warning to Injectable Promethazine,"Intravenous administration of promethazine can cause severe tissue injury, including gangrene, requiring fasciotomy, skin graft, and/or amputation, according to the FDA."
  September 2009 ,Medscape Medical News,Depot Medroxyprogesterone Acetate and Fracture Risk in Young Women,"Prolonged depot medroxyprogesterone acetate contraceptive use is associated with an increased risk for fractures in women, but socioeconomic confounders might be clouding the findings."
  September 2009 ,Medscape Medical News,Budesonide for 12 Months Not Linked to Pneumonia  Risk in COPD Patients,Budesonide treatment for 12 months did not increase the risk for pneumonia in patients with chronic obstructive pulmonary disease during that time and was safe for clinical use in such patients.
  September 2009 ,Medscape Medical News,"FDA Safety Changes: Actonel, Gardasil, Myfortic","The FDA has approved safety labeling revisions for risedronate sodium tablets, human papillomavirus quadrivalent [recombinant] vaccine, and mycophenolic acid delayed-release tablets."
  September 2009 ,Medscape Medical News,Hormonal Therapy for Breast Cancer May Affect Contralateral Cancer Risk,Long-term tamoxifen use was linked to a lower risk for contralateral estrogen receptor–positive breast cancer but a 4.4-fold increased risk for contralateral estrogen receptor–negative breast cancer.
  September 2009 ,Medscape Medical News,Q&As on Cancer Risk With TNF Blockers in Children,"The FDA announced yesterday it has posted supplemental Q&As on the increased risk for lymphoma and other cancers in children and adolescents receiving the tumor necrosis factor (TNF) blockers infliximab (Remicade), adalimumab (Humira), certolizumab (Cimzia), etanercept (Enbrel), and golimumab (Simponi)."
  August 2009 ,Medscape Medical News,FDA Revises Warning for Etravirine,The FDA has issued an alert to warn of severe skin reactions and possible life-threatening adverse events in patients who use etravirine.
  August 2009 ,Medscape Medical News,FDA to Investigate Liver-Related Adverse Events Seen With Orlistat,The FDA has warned healthcare professionals about the potential for liver-related adverse events with the weight-loss drug orlistat.
  August 2009 ,Medscape Medical News,Accusure Insulin Syringes Voluntarily Recalled,Accusure insulin syringes distributed nationwide from January 2007 through June 2008 are undergoing voluntary recall because of the detachment of needles from the syringes.
  December 2009 ,Medscape Medical News,Medroxyprogesterone Helpful for Hot Flushes in Men Receiving Hormone Therapy,"In a randomized trial, medroxyprogesterone was the best treatment of hot flushes in men undergoing hormone therapy for prostate cancer."
  December 2009 ,Medscape Medical News,Potential Benefits of Shock Wave Lithotripsy May Outweigh Risks,A white paper from the American Urological Association states that the potential benefits of shock wave lithotripsy outweigh the foreseeable risks.
  November 2009 ,Medscape Medical News,Acetaminophen Use During Pregnancy May Not Increase Asthma Risk in Offspring,"In a prospective study, acetaminophen use during pregnancy was not associated with an increased risk for asthma in the children."
  November 2009 ,Medscape Medical News,Patients and Doctors Differ When Reporting Adverse Events,"Although clinician and patient reporting of treatment-related adverse effects differ from each another, together they are complementary and provide a more complete picture."
  November 2009 ,Medscape Medical News,Certain Genzyme Products for Rare Disorders Potentially Contaminated,"Certain Genzyme products may be contaminated with stainless steel particles and other foreign matter, and the FDA recommends careful visual inspection of the products before use."
  November 2009 ,Medscape Medical News,Infusion of Local Anesthetic Linked to Postsurgical Chondrolysis,Chondrolysis has been reported in patients receiving continuous intra-articular infusions of local anesthetics with elastomeric infusion devices to control postsurgical pain.
  November 2009 ,Medscape Medical News,"FDA Safety Changes: DepoDur, Neoral, Lexiva","The FDA has approved safety labeling revisions for morphine sulfate extended-release liposome injection, cyclosporine capsules and oral solution, and fosamprenavir calcium tablets and oral suspension."
  October 2009 ,Medscape Medical News,"More Suicidal Ideation With Nortriptyline vs Escitalopram Among Men, but Both Drugs Decrease Adverse Effects","Men treated for depression with nortriptyline had almost a 10-fold increase in suicidal thoughts at 5 weeks vs men treated with escitalopram, but both drugs effectively reduced suicidal ideation."
  October 2009 ,Medscape Medical News,"FDA Safety Changes: Ultram, Ultracet, Sustiva, Kayexalate","The FDA has approved safety labeling revisions for tramadol HCl tablets, tramadol plus acetaminophen tablets, efavirenz capsules and tablets, and sodium polystyrene sulfonate powder."
  October 2009 ,Medscape Medical News,Thiopurine for IBD Linked to Risk for Lymphoproliferative Disorders,"In a prospective observational cohort study, patients receiving thiopurines for inflammatory bowel disease had an increased risk for the development of lymphoproliferative disorders."
  October 2009 ,Heartwire from Medscape,Event Rates and Trial Results,The low event rate in the RECORD trial of rosiglitazone has led some to question the validity of the results. 
  October 2009 ,Medscape Medical News,Nontramadol Opioids Should Not Be Routinely Used for Osteoarthritis,": In a review, small to moderate benefits of nontramadol opioids were outweighed by large increases in risk for adverse events; these should not be used routinely even if osteoarthritic pain is severe."
  October 2009 ,Medscape Medical News,"FDA Safety Changes: Symbyax, Zoladex, INOmax","The FDA has approved safety labeling revisions for olanzapine/fluoxetine HCl capsules (Symbyax), goserelin acetate implants (Zoladex), and nitric oxide for inhalation (INOmax)."
  October 2009 ,Heartwire from Medscape,SLCO1B1 Gene,"Carriers of the SLCO1B1*5 allele are at a twofold increased risk of mild statin-induced side effects, and the majority of these individuals had normal creatine-kinase levels."
  October 2009 ,Medscape Medical News,Certain Prophylactic Medications Reduce Risk for Breast Cancer but May Increase Other Risks,"A systematic review shows a reduced risk for primary breast cancer but an increased risk for thromboembolic events (tamoxifen, raloxifene), endometrial cancer (tamoxifen), or stroke (tibolone)."
  October 2009 ,Medscape Medical News,New-Onset Breast Tenderness During Hormone Therapy Linked to Breast Cancer Risk,"In a randomized controlled trial, new-onset breast tenderness during conjugated equine estrogens plus medroxyprogesterone therapy was associated with increased breast cancer risk."
  October 2009 ,Medscape Medical News,FDA Warns Against Use of Zanamivir With Nebulizer,The FDA and GlaxoSmithKline are reporting the death of a person with influenza after receiving zanamivir inhalation powder (Relenza) that had been dissolved and administered with a nebulizer.
  October 2009 ,Medscape Medical News,ACEIs More Likely Than Other Antihypertensive Drugs to Cause Hyperkalemia,"However, in nondiabetic patients with hypertensive chronic kidney disease treated with angiotensin-converting enzyme inhibitors, the risk for hyperkalemia is small."
  October 2009 ,Medscape Medical News,"FDA Safety Changes: Arixtra, Sulfonylureas, Tobramycin","The FDA has approved safety labeling revisions for fondaparinux sodium, glipizide and glipizide extended-release tablets, micronized glyburide, glipizide/metformin, glyburide, and tobramycin."
  October 2009 ,Medscape Medical News,Thiazolidinediones Linked to Bone Fracture Risk,"In a UK database study, nearly one and half times as many fractures occurred when people were taking thiazolidinediones than when they were not taking these drugs, after adjustment for age."
  March 2010 ,Medscape Medical News,Antidepressants May Permanently or Reversibly Affect Fetal Brain Development,The timing of antidepressant exposure during pregnancy may determine whether the effects on fetal brain development are permanent or reversible.
  March 2010 ,Heartwire from Medscape,"Statin ""Preconditioning"" Effect Blunted by COX-2 Inhibitor in Volunteers",The COX-2 inhibitor celecoxib completely abolished the beneficial preconditioning effect of rosuvastatin in a small mechanistic study in human volunteers. 
  February 2010 ,Heartwire from Medscape,GlaxoSmithKline Fires Back,"In its response, the company states it has been ""proactive in investigating the safety data"" of rosiglitazone and is critical of the Senate report that ignores other data, including DREAM, ADOPT, and RECORD."
  February 2010 ,Medscape Medical News,Thiazolidinedione Use Linked to Increased Fracture Risk in Women,"A study shows that thiazolidinedione use is associated with an increased risk for fractures in women, particularly in those older than 65 years."
  February 2010 ,Heartwire from Medscape,Saquinavir and Ritonavir: Arrhythmia Risks ,"Preliminary data suggest that the combination of saquinavir and ritonavir may cause prolongation of the QT and PR intervals, leading to an increased risk of torsades de pointes and heart block, respectively."
  February 2010 ,Medscape Medical News,"FDA Studying 27 Drugs, Drug Classes for Potential Safety Issues",A medication's appearance on the list does not mean physicians should stop prescribing it. 
  February 2010 ,Medscape Medical News,FDA Mandates New Safety Controls for Long-Acting Beta Agonists,"Once asthma control is achieved, patients should be switched from combination corticosteroid-LABA therapy to a corticosteroid or another long-term asthma controller medication without a LABA."
  February 2010 ,Medscape Medical News,New Boxed Warning for Deferasirox,The prescribing information for deferasirox has been updated to describe risks for kidney and liver failure and gastrointestinal hemorrhage and includes a new black box warning.
  February 2010 ,WebMD Health News,FDA Warns of Maalox Mix-up Danger,The agency says some consumers are confusing Maalox antacids with a product called 'Maalox Total Relief.''
  February 2010 ,Medscape Medical News,HRT With Estrogen Alone Increases Risk for Asthma Onset After Menopause,"Estrogen-only hormone replacement therapy has been found to be linked to an increased risk for the development of asthma after menopause, according to a large cohort study of postmenopausal women."
  February 2010 ,Heartwire from Medscape,Avandia Raises Heart-Failure Risk in RECORD Randomized Trial,The secondary finding from the controversial trial is consistent with an interim analysis conducted several years ago.
  February 2010 ,Medscape Medical News,Deaths From Methadone Overdose Disproportionate to Number of Prescriptions,A national review of opioid-related deaths finds that methadone plays a larger role than other drugs.
  February 2010 ,Medscape Medical News,PML Risk Increases With Repeated Natalizumab Infusions: FDA,"The Food and Drug Administration released new safety information gleaned from the 31 cases of PML to date, but still conclude the clinical benefit for patients outweighs the risks. "
  January 2010 ,Medscape Medical News,Didanosine Associated With Noncirrhotic Portal Hypertension,"Postmarketing reports of noncirrhotic portal hypertension, including 4 deaths, have resulted in an update of the didanosine label."
  December 2009 ,Medscape Medical News,"Quitting Smoking, Increased Calcium May Lower BMD Loss Linked to DMPA Use",Quitting smoking and increasing calcium intake may reduce the risk for higher bone mineral density loss associated with use of depot medroxyprogesterone acetate.
  December 2009 ,Medscape Medical News,Recommendations for Prescribing NSAIDs in the Primary Care Setting,A review article provides recommendations for prescribing nonsteroidal anti-inflammatory drugs in the primary care setting.
  December 2009 ,Medscape Medical News,Intravitreal Triamcinolone May Slow Diabetic Retinopathy Progression,"Because adverse effects include cataract formation and glaucoma, the investigators did not recommend this treatment merely to reduce progression of proliferative diabetic retinopathy."
  December 2009 ,Medscape Medical News,Low-Dose Aspirin During Pregnancy Has No Adverse Impact on Preterm Infants,"Aspirin may actually reduce neurobehavioral issues, according to a recent study."
  December 2009 ,Reuters Health Information,High-Dose Inhaled Steroids for Asthma May Increase Risk of Fetal Malformations,The congenital malformation rate for pregnant women who used more than 1000 micrograms per day was much higher than that seen in nonusers and in users of no more than 1000 micrograms per day.
  December 2009 ,Medscape Medical News,Suicide Warning on Epilepsy Drugs Intensifies Clinical Responsibility,New warnings on antiepileptic drugs unambiguously state the need to screen for psychiatric disorders and will have medical-legal implications for clinicians.
  April 2010 ,Medscape Medical News,FDA Safety Changes: Lotrel,The FDA has approved revisions to the safety labeling for amlodipine besylate plus benazepril HCl capsules.
  April 2010 ,Medscape Medical News,Medication Side Effects in Depressed Outpatients Often Go Undetected ,"New research shows clinicians only pick up a fraction of the side effects related to antidepressant medications, a finding that highlights the need for better monitoring experts say. "
  April 2010 ,Medscape Medical News,FDA Safety Changes: Caduet,The FDA has approved revisions to the safety labeling for amlodipine besylate plus atorvastatin calcium tablets.
  April 2010 ,Heartwire from Medscape,Discharge Clopidogrel Delay ups Events,"One in six patients do not immediately fill their initial prescription for clopidogrel after hospital discharge, and such a delay is associated with an increased risk of adverse outcomes, a new study shows. "
  April 2010 ,Medscape Medical News,Similar Adverse Effects for Epilepsy Patients on Monotherapy or Polytherapy ,A new study suggests fear of increased toxicity with multiple drugs may not be warranted.
  April 2010 ,Medscape Medical News,FDA Adds Boxed Warning to Propylthiouracil,"The new warning includes a postmarketing data review of cases of severe liver injury and acute liver   failure, some fatal, as well as information on whether to use the drug in pregnancy."
  April 2010 ,Heartwire from Medscape,Common UTI Antibiotic Risky in Warfarin Setting ,Urinary-tract infections are one of the most common infections in older patients taking warfarin; now new research shows that the most commonly used antibiotic may quadruple the risk of upper-GI bleeding. 
  April 2010 ,Medscape Medical News,FDA Tightens Approval Process for Radiotherapy Devices,The agency continues its war against equipment problems and operator errors that result in radiation overdoses.
  April 2010 ,Medscape Medical News,Flu Shot Without Skin Testing May Be Safe for Egg-Allergic Patients,"A study suggests that patients without anaphylaxis to egg may safely receive the influenza vaccine in a 2-dose, graded fashion without a vaccine skin test."
  April 2010 ,Medscape Medical News,Hormone Therapy for Menopause Reviewed,A review states that women must be informed of benefits and risks of all treatment options and should receive individualized care for menopausal symptoms.
  April 2010 ,Medscape Medical News,Antepartum Antiviral Treatment of H1N1 Influenza Not Linked to Adverse Outcomes,"In a retrospective cohort study, there was no evidence of an association between antepartum antiviral exposure and adverse maternal or neonatal outcomes."
  April 2010 ,Medscape Medical News,Antipsychotic Drugs May Boost Pneumonia Risk in Elderly Outpatients,"A case-control study finds the association was dose dependent, occurred with both atypical and typical antipsychotics, and appeared to be most pronounced during the first week of treatment. "
  April 2010 ,Medscape Medical News,FDA Reviewing Data on Possible Increased Prostate Cancer Risk With Stalevo in PD ,The agency stresses their review is ongoing and no new conclusions or recommendations are being made at this time. 
  March 2010 ,Medscape Medical News,Overall Mortality in Type 2 Diabetes May Be Similar With Some Sulfonylureas,"Risk for overall mortality was similar in patients with type 2 diabetes receiving glipizide, glyburide, or glimepiride monotherapy, but glimepiride was preferred in those with coronary artery disease."
  March 2010 ,Medscape Medical News,Femur Fractures Rare With Bisphosphonate Use," In an analysis of 3 trials, fractures of the subtrochanteric or diaphyseal femur were very rare, even in women treated with bisphosphonates for up to 10 years."
  March 2010 ,Medscape Medical News,PPIs May Help Reduce Hospitalizations for Gastroduodenal Bleeding,Concurrent use of proton pump inhibitors in patients with serious coronary heart disease treated with clopidogrel was associated with fewer hospitalizations for gastroduodenal bleeding.
  March 2010 ,Medscape Medical News,"High-Dose Simvastatin Associated With Increased Risk for Myopathy, FDA Warns","A simvastatin dose of 80 mg is associated with an increased risk for myopathy compared with lower doses and other statins, according to an FDA review of clinical trial and other data."
  March 2010 ,Medscape Medical News,Oral Contraception May Not Increase Long-Term Mortality Rate,"In a large UK cohort, oral contraception was not associated with an increased long-term risk for death but was actually associated with a net benefit."
  March 2010 ,Medscape Medical News,Norepinephrine and Dopamine in Treatment of Shock,"Although there was no significant difference in death rates between patients treated with dopamine and those treated with norepinephrine, dopamine was linked with twice as many adverse events."
  March 2010 ,Medscape Medical News,Regular Analgesic Use May Increase Risk for Hearing Loss,"Regular use of aspirin, acetaminophen, and nonsteroidal anti-inflammatory drugs may increase the risk for hearing loss in men, particularly those younger than 60 years."
  June 2010 ,Medscape Medical News,High-Dose B Vitamin Therapy May Not Be Helpful in Diabetic Nephropathy,"In a randomized trial in diabetic nephropathy, high doses of B vitamins vs placebo resulted in a greater decrease in glomerular filtration rate and an increase in vascular events."
  June 2010 ,Medscape Medical News,FDA Warns Against Use of 3 Recalled IV Medications ,"The agency's announcement about the potential contamination risks for metronidazole, ciprofloxacin, and ondansetron follows a recall of metronidazole from Sagent Pharmaceuticals."
  May 2010 ,Medscape Medical News,FDA Adds Risk for Severe Liver Injury to Orlistat Label,"The agency notes, however, that it has not yet established a cause-and-effect relationship between orlistat use and liver damage."
  May 2010 ,Medscape Medical News,FDA Warns of Suicide Risk for Tramadol,The agency also is advising physicians that the opioid may be sought by patients with drug abuse and addiction problems or those with criminal diversion in mind.
  May 2010 ,Medscape Medical News,"Proton Pump Inhibitors May Increase Fracture Risk, FDA Warns",Physicians should consider whether a lower dose or a shorter duration of PPI therapy would adequately treat gastroesophageal reflux disease and other indicated conditions.
  May 2010 ,Medscape Medical News,FDA and NIH Launch Safety Reporting Web Site,"The new Safety Reporting Portal will deal with food safety, while MedWatch will remain focused on drugs and devices; the 2 Web sites will eventually merge. "
  May 2010 ,Medscape Medical News,Long-Term Metformin Treatment Linked to Vitamin B12 Deficiency,"Long-term treatment with metformin increased the risk for vitamin B12 deficiency, which may be preventable, and increased homocysteine concentrations in patients with type 2 diabetes."
  May 2010 ,Medscape Medical News,Dermatologic Use of Retinoid Drugs Not Linked to Increased Fracture Risk,"A case-control study shows that patients treated for acne, psoriasis, or another skin condition with vitamin A analogues are not at increased risk for fracture."
  May 2010 ,Medscape Medical News,"Tapentadol Sometimes Better Tolerated, But Opioids Still First Line",A new post hoc analysis of 1-year safety data for tapentadol extended release in low back pain or osteoarthritis shows that the drug has a good safety profile.
  May 2010 ,Medscape Medical News,Hyaluronidase Product Recalled Because of Contamination,A voluntary recall has been issued for all lots of Baxter's hyaluronidase human injection because of the presence of particulate matter.
  May 2010 ,Medscape Medical News,Sagent Pharmaceuticals Recalls Metronidazole Injection,The voluntary nationwide recall of the antibiotic follows the discovery of 2 lots that were not sterile.
  May 2010 ,Medscape Medical News,Promacta Study Halted Due to Increased Risk for Portal Venous Thrombosis in Liver Disease Patients,"In the ELEVATE study, 4% of patients receiving eltrombopag and 1% of those receiving placebo developed portal venous thrombosis."
  May 2010 ,WebMD Health News,FDA: Don't Swallow Benadryl Gel,The agency warns of serious side effects in people who mistakenly swallow Benadryl Extra Strength Itch Stopping Gel.
  May 2010 ,Medscape Medical News,High-Dose PPIs May Be No More Effective Than Lower Doses for Bleeding Peptic Ulcer,"Compared with non-high-dose proton pump inhibitors, high doses did not further reduce rates of rebleeding, surgical intervention, or mortality after endoscopic treatment of bleeding peptic ulcer."
  May 2010 ,Medscape Medical News,"PPI Use Not Linked With Hip Fractures, but Modestly With Other Types of Fractures","In postmenopausal women, use of proton pump inhibitors was, however, modestly associated with clinical spine fractures, forearm or wrist fractures, and total fractures."
  May 2010 ,Medscape Medical News,Proton Pump Inhibitor Use Linked to Clostridium Difficile Infection,A study shows a 74% increase in Clostridium difficile infection with daily use of proton pump inhibitors; a second study shows a 42% increased risk for recurrence with proton pump inhibitors.
  May 2010 ,Medscape Medical News,Management of Serotonin Syndrome Reviewed,"A review for family physicians describes prevention, diagnosis, and management of serotonin syndrome."
  May 2010 ,Medscape Medical News,Naltrexone Extended-Release Prescribing Information Strengthened,Naltrexone extended-release injectable suspension has been associated with injection-site reactions based on postmarketing data; the prescribing information has been updated to reflect these data.
  April 2010 ,Medscape Medical News,Long-Term Pulmonary Problems After HSCT for Leukemia ,"Hematopoietic stem cell transplantation (HSCT) often cures leukemia, but the grueling treatment can have a long-term adverse effect on the lungs. "
  April 2010 ,Medscape Medical News,Risk for Low-Dose Aspirin-Associated Peptic Ulcer Higher in Elderly Women,A study shows sex differences in the clinical features and risk factors for low-dose aspirin-associated peptic ulcer.
  July 2010 ,Heartwire from Medscape,Coumadin Samples Recalled in US,"BMS has voluntarily recalled a number of blister packs of Coumadin 1 mg provided as samples in the US, because they may not contain the right amount of an additive, isopropanol. There is little clinical risk from this situation, the company says."
  July 2010 ,Medscape Medical News,Iron Dextran Has Highest Adverse Effects Rate of All IV Iron Products,Reported rates of adverse effects from iron dextran in Europe and North America over a 6-year period were much higher than for other intravenous (IV) iron products.
  July 2010 ,Medscape Medical News,Psychotropic Medications Linked to Serious Adverse Drug Reactions in Children ,Psychotropic medications were associated with almost 10% of the adverse drug reactions reported in all children in Denmark (from the age of birth to 17 years) between the years 1998 and 2007. 
  July 2010 ,Medscape Medical News,13 Drugs on Latest FDA List for Safety Monitoring,Physicians should not stop prescribing these medications because the agency has yet to establish a causal relationship with the health risks in question. 
  July 2010 ,Medscape Medical News,Increased CV Events Halts Testosterone Trial in Older Men,A study to assess testosterone treatment in men 65 years and older who have limitations in mobility has been stopped prematurely because of an increased risk for cardiovascular adverse events.
  June 2010 ,Medscape Medical News,Hip Fractures Linked to Thiazolidinedione Use Higher Than Expected in Men,"Fractures associated with the use of rosiglitazone and pioglitazone occur in both women and men; however, middle-aged men have a 2-fold increased risk for hip fracture from thiazolidinedione use."
  June 2010 ,Medscape Medical News,Endocrine Society Issues Position Statement on Menopausal Hormone Therapy,"A new Endocrine Society scientific statement evaluates benefits and risks for postmenopausal hormone replacement therapy, now known as menopausal hormone therapy."
  June 2010 ,Medscape Medical News,Vaginal Isosorbide Mononitrate Does Not Decrease Time to Vaginal Delivery,The addition of vaginal isosorbide mononitrate to oral misoprostol for cervical ripening and labor induction did not reduce time to vaginal delivery and was associated with a greater incidence of headache.
  June 2010 ,Medscape Medical News,Digoxin Use Linked to Mortality in End-Stage Renal Disease,"In a retrospective cohort, digoxin use in patients receiving hemodialysis was associated with increased mortality rates, especially among patients with low predialysis potassium levels."
  June 2010 ,Medscape Medical News,"SSRIs, Amantadine May Affect Vision in Elderly","SSRI antidepressants and amantadine have been linked to cataracts and corneal damage, respectively."
  June 2010 ,Medscape Medical News,FDA Committee Votes in Favor of Current Safety Monitoring for Most Drugs,The committee to the FDA did not have changes to safety monitoring for any of the drugs evaluated except for desflurane.
  June 2010 ,Medscape Medical News,Gemtuzumab Voluntarily Withdrawn From US Market,"Based on discussions with the FDA, Pfizer has announced a voluntary withdrawal of gemtuzumab in the United States. Reasons cited are lack of benefit and safety concerns."
  June 2010 ,Medscape Medical News,EPINEPHrine Shortage May Result in Dangerous Medication Errors ,"A shortage of EPINEPHrine prefilled syringes may cause serious medication errors, with 1 death reported from an overdose of EPINEPHrine. "
  June 2010 ,Medscape Medical News,Selective COX-2 Inhibitors Cause Less GI Irritation Than NSAID Plus PPI,A selective COX-2 inhibitor provides more gastrointestinal (GI) safety than a nonselective nonsteroidal anti-inflammatory drug (NSAID) plus a proton pump inhibitor (PPI) in patients with arthritis.
  June 2010 ,Heartwire from Medscape,Cardiotoxicity Echo Study,Myocardial longitudinal strain and cardiac troponin plasma concentrations may help identify patients in whom anthracyclines and trastuzumab are cardiotoxic.
  June 2010 ,Heartwire from Medscape,FDA Conducts Safety Review of Antihypertensive ARB Olmesartan,"There were cautionary signals in two placebo-controlled hypertension trials; still, the agency says, it believes the benefits of the drug, marketed by Daiichi Sankyo as Benicar, ""outweigh its potential risks.""  "
  June 2010 ,Heartwire from Medscape,"ARBs, Primarily Telmisartan, Linked to 25% Increased Risk of Lung Cancer ","Angiotensin-receptor blockers have been associated with a modest increased risk of developing cancer in a new meta-analysis. Specifically, there was a significant 25% increased risk of lung cancer with these agents. The results, while concerning, must be considered preliminary, say the researchers, who call for the FDA to further examine the issue."
  June 2010 ,Heartwire from Medscape,Pfizer Slow to Share Lipitor Adverse Event Reports With FDA,"The 12-page letter documents increasing numbers of adverse-event reports that are not being shared with the FDA within the stipulated 15-day window, including adverse reactions to the company's blockbuster statin, Lipitor. "
  June 2010 ,Medscape Medical News,Valproic Acid in Pregnancy Linked to Several Congenital Malformations,A large Swedish observational study confirms link to spina bifida and 5 other malformations.
  June 2010 ,Heartwire from Medscape,Interactions With New Anticoagulants,"At present, there are few documented interactions with the new drugs, including dabigatran, rivaroxaban, and apixaban, but considering the extensive food and drug interactions with warfarin, caution should be taken with the new agents, according to researchers."
  August 2010 ,Medscape Medical News,"Valproate Reduces 2 Key Proteins, Leading to Bone Loss ","A new study shows that the long-term use of valproate, a drug commonly used to treat epilepsy and bipolar disorder, may decrease the production of both collagen and osteonectin."
  August 2010 ,Heartwire from Medscape,Mipomersen in Hypercholesterolemia,"The drug significantly lowered LDL-cholesterol levels in hypercholesterolemia patients, but questions about the drug's effect on the liver are still unanswered. "
  August 2010 ,Medscape Medical News,TZDs May Increase Fracture Risk in Postmenopausal Diabetic Women and in Some Men,A study shows that both rosiglitazone and pioglitazone are associated with fractures in postmenopausal women and in a subset of men and that fracture risk is increased with dose.
  August 2010 ,Medscape Medical News,Cardiotoxicity of Childhood Cancer Treatments Affects Adult Survivors,"Potentially cardiotoxic cancer treatment during childhood may have long-lasting, subclinical cardiovascular effects in young adults, new research suggests."
  August 2010 ,Medscape Medical News,FDA Again Warns Against IV Administration of Nimodipine ,The FDA urges healthcare professionals to advise their patients who spray the drug on their forearm to keep children and pets from coming into contact with the medicated area of skin.
  July 2010 ,Medscape Medical News,"Exposure to Estradiol Transdermal Spray Risky for Children and Pets, FDA Says","In 7 cases reviewed by the FDA, patients developed eosinophilic pneumonia 2 to 4 weeks after starting daptomycin treatment. "
  July 2010 ,Medscape Medical News,Daptomycin May Be Linked to Eosinophilic Pneumonia,Only newer AEDs with high potential of causing depression were linked to increased suicide risk in a new study. 
  July 2010 ,Medscape Medical News,Not All Antiepileptics Have Excess Risk for Suicidality ,"Within 3 days after receipt of the diphtheria-tetanus-acellular pertussis vaccine in early childhood, there was no increased risk for seizures."
  July 2010 ,Medscape Medical News,DTaP in Early Childhood Not Linked to Increased Seizure Risk Within 3 Days,Enrollment in the controversial study assessing the cardiovascular effects of long-term treatment with rosiglitazone or pioglitazone has been stopped at the FDA's request.
  July 2010 ,Heartwire from Medscape,TIDE Enrolment Suspended,"Dr David Capuzzi earned $14 750 as a member of the company's speaker's bureau, but received the money related to talks about Lovaza and not for rosiglitazone. Dr Abraham Thomas received a few thousand dollars for speaking on behalf of pioglitazone, Avandia's rival. "
  July 2010 ,Heartwire from Medscape,"Capuzzi, Thomas, and Avandia",A joint statement from 3 specialty groups stresses that patients on the controversial medication should keep taking it unless instructed otherwise by their healthcare provider. 
  July 2010 ,Medscape Medical News,"Patients With Diabetes Have Alternatives to Rosiglitazone, Experts Say","A practical, simple method of identifying elderly inpatients at increased risk for an adverse drug reaction may be useful in clinical practice and in research."
  July 2010 ,Medscape Medical News,Simple Tool May Identify Patients at Increased Risk for Adverse Drug Reaction,The US FDA has become the latest regulatory agency to say it will investigate a possible link between angiotensin-receptor blockers and cancer. 
  July 2010 ,Heartwire from Medscape,US Agency Will Review ARBs for Possible Cancer Risk ,"Near the end of two days of exhaustive, often-polarized debate, 12 panel members said the drug should be withdrawn, with no other choice getting as many votes. But the other 20 votes were spread across three out of four other options, all suggesting that the drug could stay on the market, with certain provisions."
  July 2010 ,Heartwire from Medscape,FDA Advisory Committee Sends Mixed Message to FDA,A marathon of 11 hours of presentations has likely left the joint Endocrinologic and Metabolic Drugs and Drug Safety and Risk Management Advisory Committees reeling in confusion. Day two promises more time for questions and reflection before the all-important vote.
  July 2010 ,Heartwire from Medscape,Day-One Data Deluge at FDA Rosiglitazone Meeting ,More cases of this adverse event prompted the agency to strengthen an existing warning on the label for the rheumatoid arthritis drug.
  July 2010 ,Medscape Medical News,FDA Adds Boxed Warning to Leflunomide for Severe Liver Injury,The agency has received reports of gas or air embolisms after the administration of hemostatic drugs and biological products with sprayers pressurized by gas and air.
  July 2010 ,Medscape Medical News,"Use Fibrin Sprayers Correctly to Avoid Embolisms, Warns FDA","A new analysis of the ONSET/OFFSET study with ticagrelor, which prospectively assessed the side effect of dyspnea and whether this affected cardiac and pulmonary function, provides reassurance that this adverse effect, while common, is generally mild and self-limiting, say the investigators."
  July 2010 ,Heartwire from Medscape,"""Reassuring"" Prospective Data on Dyspnea With Ticagrelor","Treating such cramps with quinine is an off-label use with potentially serious adverse effects, the agency says. "
  September 2010 ,Medscape Medical News,FDA May Revise Bisphosphonate Labels in Light of Possible Fracture Risk,A new expert panel report states that clinicians should not prescribe bisphosphonates for patients with a low risk for osteoporosis-related fractures and should consider other drugs for spinal osteoporosis.
  September 2010 ,Medscape Medical News,More Evidence Sedatives May Raise Risk of Premature Death,"""Small but significant"" increase in mortality risk seen among anxiolytic and hypnotic drug users in a Canadian study. "
  September 2010 ,Heartwire from Medscape,FDA Rosiglitazone Bias?,Two employees of the FDA have raised questions about members of a previous advisory panel who had already voted to keep rosiglitazone on the market being invited to the recent review meeting to decide the future of the drug. 
  September 2010 ,Medscape Medical News,Optimal Antiemetic Therapy Remains Elusive for Pediatric Cancer Patients,"Data are limited, and information about the most effective antiemetics to prevent chemotherapy-induced nausea and vomiting in children is incomplete and imprecise. "
  September 2010 ,Medscape Medical News,Two Hepatitis C Drug Candidates on Hold Because of Adverse Events,"An elevated liver function test for 1 patient appears to be related to gallstones, according to the chief medical officer of Idenix."
  September 2010 ,Heartwire from Medscape,British Said Rosiglitazone Should Be Withdrawn; Europeans Discuss,"It has emerged this week that UK experts recommended the withdrawal of the diabetes drug rosiglitazone from the British market in July, although this recommendation was not made public at the time. "
  September 2010 ,Medscape Medical News,Use of Postnatal Corticosteroids in Bronchopulmonary Dysplasia Reviewed,The American Academy of Pediatrics has issued a policy statement on use of postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia.
  September 2010 ,Medscape Medical News,Sibutramine and Increased Risk for Nonfatal Vascular Events in Preexisting CVD,Subjects with preexisting cardiovascular disease given sibutramine treatment had an increased risk for nonfatal myocardial infarction and nonfatal stroke but not cardiovascular or all-cause death.
  September 2010 ,Medscape Medical News,Tigecycline Linked to Increased Mortality Risk,"The increased mortality risk is most evident in patients treated for hospital-acquired pneumonia, and particularly ventilator-associated pneumonia, which is an unapproved indication."
  August 2010 ,Reuters Health Information,Several Factors Increase Fracture Risk With Androgen Deprivation for Pro...,A Canadian study has identified several readily available clinical factors that help determine the risk of fractures in men with prostate cancer undergoing androgen deprivation therapy (ADT).
  August 2010 ,Medscape Medical News,FDA's Oversight Board Sees Growing Range of Drug Safety Issues,"In the 5 years since the FDA's Drug Safety Oversight Board was formed, the topics discussed have evolved from a single drug or drug class to much broader drug safety issues."
  August 2010 ,Medscape Medical News,"Certain Octagam Lots Recalled After Reports of Blood Clots, Embolisms ",The immune globulin G intravenous (human) 5% liquid preparation is used to treat primary immune deficient diseases.
  August 2010 ,Heartwire from Medscape,Thiazolidinediones Compared: Comparable CV Risk,"The study isn't a substitute for a bona fide prospective randomized trial, but it is large and controlled for a lot of potential confounders. Why its conclusions contrast with those of some prior studies isn't known for sure, but there's at least one good possible reason. "
  August 2010 ,Medscape Medical News,"Acyclovir, Valacyclovir in First Trimester Not Linked to Major Birth Defects","In a large nationwide cohort, use of acyclovir or valacyclovir in the first trimester of pregnancy was not associated with an increased risk for major birth defects."
  August 2010 ,Medscape Medical News,EEG Testing May Predict Clozapine Response in Treatment-Resistant Schizophrenia ,"A new pilot study suggests that EEG testing can predict whether patients with treatment-resistant schizophrenia will respond to clozapine, a drug known for its potentially serious adverse effects."
  August 2010 ,Heartwire from Medscape,Withdrawal of Midodrine,"The FDA is recommending the withdrawal of midodrine hydrochloride, currently used in the treatment of hypotension, because there are insufficient data to support its benefit. "
  August 2010 ,Medscape Medical News,Nebulized 3% Saline Without Bronchodilators May Be Safe for Bronchiolitis,"In a retrospective cohort, nebulized 3% saline solution without adjunctive bronchodilators for inpatients with bronchiolitis had a low rate of adverse events."
  August 2010 ,Heartwire from Medscape,Truncated Rimonabant Study Published,"Truncated results from rimonabant's large morbidity and mortality study, a report that editorialists call ""the obituary for a wonder drug,"" are reported this week. The CRESCENDO investigators, however, did not want the trial stopped, but a decision by the EMA tied their clinical hands."
  August 2010 ,Medscape Medical News,Acetaminophen Use in Adolescents May Double Risk for Asthma,"A global study shows that acetaminophen use in adolescents is linked to the development and/or maintenance of asthma, rhinoconjunctivitis, and eczema."
  August 2010 ,Medscape Medical News,FDA Warns of Aseptic Meningitis Risk With Lamotrigine ,"FDA is warning that lamotrigine (Lamictal, GlaxoSmithKline), approved for treatment of epilepsy and bipolar disorder, can cause aseptic meningitis.   "
  October 2010 ,Medscape Medical News,Multiple Courses of Antenatal Corticosteroids May Not Improve Outcomes,Multiple courses of prenatal corticosteroids every 14 days did not increase or decrease the risk for death or neurologic impairment at ages 18 to 24 months vs a single course.
  October 2010 ,WebMD Health News,FDA Warns Against Over-the-Counter Chelation Treatments,"All over-the-counter chelation treatments are illegal, says the FDA."
  October 2010 ,Heartwire from Medscape,FDA Panel to Review Darbepoetin,An early safety review posted online questions the treatment strategy in light of the absence of benefit and increased risk of stroke observed in the TREAT study.
  October 2010 ,Heartwire from Medscape,More Heparin Trouble for SPL,Scientific Protein Laboratories has been reprimanded by the US FDA for failing to investigate a complaint about contaminated heparin months after the heparin recalls in 2008.
  October 2010 ,Medscape Medical News,FDA Adds Femur Fracture Warning to Bisphosphonate Labels,The label change applies only to bisphosphonates approved for the treatment of osteoporosis.
  October 2010 ,Heartwire from Medscape,Atorvastatin Recall ,"Pfizer has recalled seven lots of atorvastatin (Lipitor) because of an ""uncharacteristic odor related to the bottles in which the product is packaged"". "
  October 2010 ,Medscape Medical News,Abbott Withdraws Sibutramine From Market,The US FDA asked the manufacturer to pull the weight-loss medication from the market after clinical trial data pointed to a 16% increase in the risk for serious cardiovascular events.
  October 2010 ,Heartwire from Medscape,COGENT Published,Patients on dual antiplatelet therapy had a significant reduction in GI events with omeprazole and no increase in cardiovascular events in the first randomized trial of PPI use with clopidogrel. And a new mechanistic study suggests that the clopidogrel-omeprazole interaction may be dose dependent.
  October 2010 ,Medscape Medical News,New Discipline of Cardioncology Evolves as Cancer Patients Live Longer ,Growing awareness about the cardiovascular adverse effects of novel anticancer drugs has given birth to a new discipline of cardioncology. 
  October 2010 ,Heartwire from Medscape,FDA Deputy on Rosiglitazone,"Dr Joshua Sharfstein, principal deputy commissioner of the FDA, discusses the recent FDA decision to allow Avandia to stay on the market with restricted access and compares the decision with the European approach that suspended the drug."
  October 2010 ,Medscape Medical News,Caffeine Intake During Pregnancy Not Linked to Risk for Preterm Birth,A meta-analysis of cohort and case-control studies shows no important association between caffeine intake during pregnancy and the risk for preterm birth.
  October 2010 ,Medscape Medical News,Medications for Insomnia or Anxiety Linked to 36% Increase in Mortality Risk,"Because sedative drug use is associated with a 36% increase in mortality risk, physicians should consider nonpharmacologic treatment options for insomnia or anxiety."
  September 2010 ,Medscape Medical News,Lots of Epogen and Procrit Recalled Due to Glass Flakes in Vials,"Several lots epoetin alfa vials are subject to recall, according to an FDA alert. "
  September 2010 ,Medscape Medical News,PPIs After MI Linked to Increased Risk for Adverse Cardiovascular Outcomes,"Proton pump inhibitors are associated with an increased risk for adverse cardiovascular outcomes after discharge in patients with myocardial infarction, regardless of clopidogrel use."
  September 2010 ,Heartwire from Medscape,"Reaction to Rosiglitazone Decisions Mixed, But Measured","Diabetes doctors convened at the EASD meeting in Stockholm have given their verdict on the differing decisions made by the European and American regulatory authorities yesterday on the fate of rosiglitazone. In the US, Nissen says he is ""pleased"" by the EMA actions; the FDA moves are ""reasonable,"" he added. "
  September 2010 ,Heartwire from Medscape,"FDA Restricts Rosiglitazone, But EMA Suspends It ","After months of deliberations, the FDA has opted to allow Avandia to stay on the market, but only with severe restrictions. It also opted to stop the TIDE trial, pending a rereview of the RECORD trial.  In contrast, the EMA has ordered the suspension of all rosiglitazone-containing products"
  September 2010 ,Heartwire from Medscape,Clopidogrel-PPI: Mechanistic Studies ,"But cardiologists continue to debate whether these results, which show a definite interaction, are clinically relevant. "
  September 2010 ,Medscape Medical News,FDA Studying Possible Link Between Pioglitazone and Bladder Cancer,"Study of 193,000 Kaiser patients shows increased risk after 24 months of treatment, but the agency has not reached any conclusions about causation. "
  September 2010 ,Heartwire from Medscape,Sibutramine Risks Warrant Restrictions or Withdrawal: FDA Panel ,"Six members of the FDA panel voted to recommend that the FDA severely restrict access to the weight-loss drug, and eight recommended the plug be pulled on it altogether. Only two on the panel reviewing the SCOUT trial concluded that the drug should remain on the market with a boxed warning only, and no members thought the drug could stay with no labeling changes.  "
  September 2010 ,Medscape Medical News,Hormonal Analog Reduces Visceral Adipose Tissue in HIV-Infected Patients,"A pooled analysis of 2 phase 3 trials shows benefits of tesamorelin across subgroups of HIV-positive patients, including sex, race, and varying disease characteristics."
  November 2010 ,Heartwire from Medscape,"Benfluorex, Hospitalizations, Deaths, Valvular Disease","The drug, available in just a handful of countries, is also used off-label to treat obesity. A new report links it to at least 500 deaths and at least 3500 hospitalizations in France."
  November 2010 ,Heartwire from Medscape,APPRAISE-2 Halted,"The move will include all propoxyphene-containing products, both brand-name and generic."
  November 2010 ,Medscape Medical News,Propoxyphene Withdrawn From US Market,This brings the total number of cases to 75.
  November 2010 ,Medscape Medical News,Biogen Reports 5 New Cases of PML With Natalizumab ,"Looking back, historians may mark 2010 as the most significant year for US medicine in decades."
  November 2010 ,Medscape Medical News,Top 10 Medical News Stories of 2010,The US Department of Health and Human Services Office of Inspector General recommends that the Medicare program expand the list of adverse events for which it will not foot the bill.
  November 2010 ,Medscape Medical News,Nearly 1 in 7 Hospitalized Medicare Patients Experience Adverse Events ,"In a study of healthy older men, dihydrotestosterone treatment for 24 months did not affect prostate growth but caused a decrease in spinal, but not hip, bone mineral density."
  November 2010 ,Medscape Medical News,Dihydrotestosterone May Not Affect Prostate Growth But May Reduce BMD,Children are more likely than adults to be positive to amoxicillin on penicillin skin testing. 
  November 2010 ,Medscape Medical News,Kids More Likely to Show Allergy to Amoxicillin Than Adults,Studies comparing topical and oral diclofenac for the treatment of knee osteoarthritis showed comparable efficacy and fewer adverse effects with the topical formulation.
  November 2010 ,Medscape Medical News,"Topical vs Oral Diclofenac: Equal Efficacy, Fewer Adverse Effects","Aromatase inhibitors are powerful medicine for postmenopausal women with breast cancer, but they also have a lot of adverse effects."
  November 2010 ,Medscape Medical News,"Aromatase Inhibitor Adverse Effects Are Like ""Menopause Plus""","A quarterly publication from the nonprofit Institute for Safe Medicine Practices has aired safety issues with Multaq, approved recently for atrial fibrillation, and questions its ""suitability for widespread use."""
  November 2010 ,Heartwire from Medscape,ISMP Report Questions Multaq Safety,The document recommends the use of proton-pump inhibitors in patients taking thienopyridine antiplatelet agents at high risk of GI bleeding but not in those at low risk; exactly how to define high- and low-risk patients is left to the individual physician. 
  November 2010 ,Heartwire from Medscape,PPIs and Antiplatelets: Consensus,"A joint panel of FDA experts has voted unanimously in favor of keeping intravenous phenytoin on the market, despite known serious adverse effects, such as purple glove syndrome."
  November 2010 ,Medscape Medical News,"Phenytoin Injection Should Stay on the Market, FDA Panels Recommend","A new meta-analysis shows that the incidence of cough occurring with ACE inhibitors is almost 10-fold higher than is stated in the drugs' labels or in the Physicians' Desk Reference. The findings are cause for concern, given that this underreporting could also be happening with more severe side effects, say the researchers; they call for the updating of drug labels to become mandatory."
  November 2010 ,Heartwire from Medscape,Nuisance Side-Effect Underreported in Label; Implications Are Important ,"A California heparin manufacturer, supplied by a company that played a role in the worldwide 2008 heparin recall, has announced a new recall that so far involves only seven lots of the product."
  November 2010 ,Heartwire from Medscape,"SPL, B Braun Medical in New Heparin Recall","The MedWatch drug safety surveillance program is passive and reactive, underutilized, and does not contain enough detail; FDA's Surveillance Initiative is intended to correct this."
  November 2010 ,Medscape Medical News,Drug Safety Surveillance,"The contaminated antimetabolite could trigger a variety of serious adverse events, depending on the kind of parenteral administration. "
  October 2010 ,Medscape Medical News,Sandoz Recalls Methotrexate Vials That May Contain Glass Flakes,Eighteen lots of fentanyl transdermal 25 mcg/hour patches are subject to voluntary recall because of the accelerated release of fentanyl in 1 patch.
  October 2010 ,Medscape Medical News,Fentanyl Transdermal System Lots Recalled,The FDA is advising clinicians to perform an electrocradiogram before starting patients on saquinavir combined with ritonavir.
  October 2010 ,Medscape Medical News,New Warning of Cardiac Risk Added to Saquinavir Label,"Patients receiving GnRH agonists may be at a ""small increased risk"" for diabetes, heart attack, stroke, and sudden death."
  January 2011 ,Medscape Medical News,"Humanized Monoclonal Antibody May Be Effective, Safe in Asthma Patients","In a systematic review, add-on therapy with a subcutaneous humanized monoclonal antibody was safe and effective in patients with moderate to severe allergic asthma."
  January 2011 ,Medscape Medical News,Fatal Medication Errors Seen With High-Dose Morphine Oral Solution,"Due to reports of serious adverse events and deaths, labeling and packaging for high-potency morphine sulfate oral solution have been revised."
  January 2011 ,Reuters Health Information,First-in-Class Antibiotic Has High Risk of Adverse Events and Death,"Despite the similar efficacy with comparator drugs, tigecycline was associated with an increased incidence of all adverse events, especially those involving the digestive system."
  January 2011 ,Medscape Medical News,Bevacizumab Increases Heart Failure in Patients With Breast Cancer,Yet another adverse effect has been reported for bevacizumab in the treatment of advanced breast cancer -- congestive heart failure.
  December 2010 ,Medscape Medical News,"Complementary, Alternative Medicine Linked to Adverse Events in Children","A surveillance study shows that complementary and alternative medicine, especially when associated with failure to use conventional medicine, can lead to serious and fatal adverse events in children."
  December 2010 ,Medscape Medical News,FDA Warns of Possible Increased Risk for Death With Somatropin,A long-term follow-up study from France hints at a possible increased risk for death in people treated with the recombinant human growth hormone somatropin during childhood. 
  December 2010 ,WebMD Health News,FDA Targets Tainted Dietary Supplements,The FDA warns supplement industry and launches a new system to notify consumers.
  December 2010 ,Medscape Medical News,FDA Warns Against Injection Dolasetron Due to Risk for Heart Arrhythmias,"Because of heart rhythm abnormalities, the FDA recommends no longer using the injectable form of dolasetron mesylate for chemotherapy-induced nausea and vomiting. "
  December 2010 ,Medscape Medical News,Candy-Like Cough Capsules May Pose Serious Risk to Young Children,The FDA reports 7 cases of accidental ingestion associated with benzonatate (Tessalon) in children younger than 10 years.
  December 2010 ,Heartwire from Medscape,Rofecoxib Risks Confirmed to Last at Least a Year After Discontinuation,A new analysis of the only other study known to have continued to follow outcomes in patients once they had stopped taking the COX-2 inhibitor rofecoxib confirms that a doubling of cardiovascular risk persisted in those who took the drug for at least a year after stopping therapy.
  December 2010 ,Heartwire from Medscape,Stopping CRESCENDO Early,"One group argues that the trial was stopped too late, noting that the adverse psychiatric profile of the drug was raised as early as 2006, months before CRESCENDO even began, while another researcher wonders whether or not genetic testing might have identified patients taking rimonabant who were at risk for suicide."
  December 2010 ,Heartwire from Medscape,Pfizer Pulls PAH Drug Due to Liver Toxicity,"Pfizer announced today that it will voluntarily withdraw sitaxentan, a drug for pulmonary arterial hypertension, following two cases of fatal liver toxicity."
  December 2010 ,Medscape Medical News,Osteoporosis Risk With Asthma and COPD Therapies Needs More Vigilance,"For patients with asthma and chronic obstructive pulmonary disease (COPD) who are taking therapies that pose a risk for osteoporosis, screening might help prevent irreversible bone loss."
  December 2010 ,Heartwire from Medscape,FDA Advisors Mostly Positive on Naltrexone/Bupropion Diet Drug,"In all, 13 panel members voted ""yes"" to the question of whether the potential benefits of naltrexone/bupropion outweigh its potential risks if used long term, while seven voted ""no."" On a separate question, eight voted to recommend that a cardiovascular outcomes study be conducted prior to drug approval, while 11 voted that such a study could happen postapproval."
  December 2010 ,Medscape Medical News,Escalated BEACOPP Superior to ABDV in Early Hodgkin's Lymphoma,"The more aggressive chemotherapy regimen gave better overall tumor control, but at the cost of greater toxicity and no survival difference. "
  December 2010 ,WebMD Health News,Invisalign 'Invisible Braces' Maker Gets FDA Warning,"Adverse events were not reported to the agency, the FDA says."
  November 2010 ,Heartwire from Medscape,"New Review Reassures on ARB/Cancer Risk, But Questions Linger","A new meta-analysis has found no increased risk of cancer or cancer death with any antihypertensive drug, including angiotensin receptor blockers, countering the conclusions of another review published earlier this year. However, the new paper did find an increased cancer risk with the combination of ARB plus ACE inhibitor, so questions still remain. Regulatory agencies are currently reviewing the"
  November 2010 ,Medscape Medical News,Therapeutic Acetaminophen Not Linked to Liver Injury in Children,A systematic review shows that hepatoxicity after therapeutic dosing of acetaminophen in children is rarely reported in defined-population studies.
  November 2010 ,Medscape Medical News,First-Trimester PPI Use May Not Significantly Increase Risk for Birth Defects,"In a large cohort, exposure to proton-pump inhibitors during the month before conception, but not during the first trimester, was associated with a significantly increased risk for major birth defects."
  November 2010 ,Medscape Medical News,Grass Allergy Immunotherapy Tablet Shows Promise for Children,A grass allergy immunotherapy tablet is effective and safe in children 5 years and older.
  February 2011 ,Medscape Medical News,Hydrocodone Bitartrate/Acetaminophen and Phenobarbital Tablets Recalled,"Mislabeled bottles may result in patients unintentionally taking one product instead of the other, with potentially serious harm. "
  February 2011 ,Medscape Medical News,Bevacizumab Linked to Fatal Adverse Effects in Cancer Patients,A meta-analysis shows that this cancer drug may be associated with an increased risk for treatment-related death.
  February 2011 ,Heartwire from Medscape,Contrave Naltrexone/Bupropion Sent Back for CVD Study,"The drug, a combination of naltrexone and bupropion HCL, had been given a positive decision by the majority of members on an FDA advisory group panel in December."
  January 2011 ,Medscape Medical News,Drug-Induced Deaths More Common Than Alcohol- or Firearm-Related Fatalities,"A new report from the CDC finds rates of drug-induced deaths are significantly higher for males than females, especially for non-Hispanic white and black males."
  January 2011 ,Heartwire from Medscape,FAST-MI Registry on Clopidogrel-PPI Interaction,"The observation was independent of whether patients carried a gene variant also associated with reduced clopidogrel effectiveness. The findings add yet more observational data to a debate that really could use a solid prospective, randomized trial."
  January 2011 ,Medscape Medical News,Vinorelbine 'Preferred' Chemo in HER2-Positive Advanced Breast Cancer,"Vinorelbine is not more effective than a taxane, according to a new phase 3 study, but it does have a better toxicity profile."
  January 2011 ,Heartwire from Medscape,ACE Inhibitors Rather Than ARBs Could Save Can$20 Million Per Year,"Restricting the prescribing of angiotensin-receptor blockers so that they are given only to patients who are intolerant to ACE inhibitors--as is done in one Canadian province--could save millions of dollars in costs without any adverse effects on cardiovascular health, say the authors of a new paper. But this assumes equivalence of the two drug classes, which is not yet proven, says one observer."
  January 2011 ,Medscape Medical News,Risk for Death After Trauma Higher in Patients Using Warfarin,"Warfarin use is associated with a significant increase in death among injured patients, even after adjustment for confounding comorbidities."
  January 2011 ,Heartwire from Medscape,Choose Azithromycin as a Macrolide if Patient Is on a CCB,"Doctors need to be aware of an underappreciated risk of hypotension associated with the use of calcium-channel blockers together with macrolide antibiotics such as erythromycin and clarithromycin, Canadian researchers say. If a macrolide-type antibiotic is needed, azithromycin--which does not increase the risk of hypotension--is a better choice, they state."
  January 2011 ,Medscape Medical News,Steroid-Dopamine Combination May Be Fatal in Septic Shock,"Steroids plus dopamine therapy are linked to increased mortality in patients with shock, especially those with septic shock."
  January 2011 ,Medscape Medical News,Propofol Infusion Syndrome Real but Rare,Propofol infusion syndrome is a real but rare entity that can be completely prevented with a simple protocol.
  January 2011 ,Heartwire from Medscape,EMA Also Wants Liver Warnings Added to Dronedarone Labeling,"Following in the footsteps of action taken in the US last week, the European Medicines Agency says urgent changes need to be made to the product information for dronedarone, indicating a possible association with liver complications."
  January 2011 ,Reuters Health Information,Sarkozy Vows Health System Fix After Drug Furor,French President Nicolas Sarkozy pledged on Thursday to shake up the healthcare system and root out fraud after a report said a drug suspected of killing more than 500 people should have been pulled years before it was.
  January 2011 ,Medscape Medical News,IMRT for Anal Cancer Associated With Fewer Adverse Events,"Without affecting 2-year outcomes, intensity-modulated radiation therapy (IMRT) had fewer adverse events than conventional radiation therapy. "
  January 2011 ,WebMD Health News,Tylenol Products Recalled,The products were made at facility where cleaning procedures were insufficient or not adequately documented.
  January 2011 ,Reuters Health Information,Few Women With RA Use Contraindicated Drugs During Pregnancy,"Only a small minority of women with rheumatoid arthritis are prescribed drugs that are contraindicated during pregnancy, but those who do take them have higher rates of spontaneous abortion."
  January 2011 ,Heartwire from Medscape,"Dronedarone Linked to Liver Damage, Transplants, Says Sanofi","Sanofi Aventis has sent out a letter to US healthcare professionals alerting them to an association between severe hepatic injury, including two liver transplants, and use of its anti-arrhythmic drug, dronedarone (Multaq). The company says it will also change the prescribing information for the product, although it stresses no causal association has yet been established. The FDA has also issued a "
  January 2011 ,Medscape Medical News,FDA Still Evaluating Insulin Glargine and Possible Cancer Risk,"The evidence showing an increased cancer risk associated with insulin glargine remains inconclusive, but the FDA is continuing its safety review of the product. "
  January 2011 ,Medscape Medical News,Tuberculosis Therapy in Older Patients Linked to Increased Adverse Events,The risk for adverse events requiring hospitalization was significantly increased in patients older than 65 years receiving treatment of latent tuberculosis infection.
  January 2011 ,Medscape Medical News,Early Antibiotic Use Linked to Asthma and Allergy at Age 6 Years,A cohort study shows that antibiotic use by age 6 months is associated with asthma and allergy at age 6 years and that protopathic bias is unlikely to explain the main findings.
  March 2011 ,Medscape Medical News,Fish Oil Helps Prevent Weight and Muscle Loss in Cancer Patients,Fish oil supplementation might prevent the muscle and weight loss that commonly occurs in cancer patients during chemotherapy.
  March 2011 ,Medscape Medical News,"Abacavir Does Not Raise MI Risk, FDA Analysis Shows",Conflicting information about abacavir's myocardial infarction risk prompted the FDA to study 26 clinical trials involving the drug in HIV-infected patients.
  March 2011 ,Medscape Medical News,Some Immune-Modifying Biologics Are Safer Than Others,Patients taking immune-modulating biologics are also likely to experience adverse effects and tuberculosis reactivation vs patients receiving placebo.
  February 2011 ,Medscape Medical News,"Coadministration of Flu, Pneumococcal Vaccines Linked to Febrile Seizures",CDC's Advisory Committee on Immunization Practices (ACIP) discusses febrile seizures associated with vaccine use.
  February 2011 ,Reuters Health Information,Negative Drug Rechallenge After Skin Reaction Predicts Long-Term Tolerance,A French study shows that patients with skin reactions to drugs who do not react to a rechallenge will likely exhibit tolerance to the drugs during the long term.
  February 2011 ,Heartwire from Medscape,"Congress Slams FDA Over Heparin Saga, Again","Representatives of the House Energy and Commerce committee are asking the agency to supply documents relating to the investigation and tests, to be delivered within two weeks."
  February 2011 ,Medscape Medical News,New Details on Osteonecrosis Risk With Bisphosphonates,Two new studies report an association between bisphosphonate use and osteonecrosis of the jaw.
  February 2011 ,Medscape Medical News,High Court Protects Vaccine Makers for 'Unavoidable' Adverse Events,"Parents still have recourse through the federally mandated ""Vaccine Court."""
  February 2011 ,Medscape Medical News,Long-Term Use of Bisphosphonates Increases Risk for Atypical Fractures,"Among older women, treatment with a bisphosphonate for more than 5 years was linked to an increased risk, but a low absolute risk, for subtrochanteric or femoral shaft fractures."
  February 2011 ,Medscape Medical News,Risks With Antipsychotics in Pregnancy Stressed in New Label ,Taking these medications during the third trimester of pregnancy puts neonates at risk for abnormal muscle movements and withdrawal symptoms. 
  February 2011 ,Medscape Medical News,Bleomycin Being Underdosed in Advanced Germ Cell Tumors?,A study of bleomycin toxicity showed that asymptomatic drops in lung function scores caused 20% of bleomycin doses to be missed and 20% of patients to receive less than their planned doses. 
  February 2011 ,Medscape Medical News,Boxed Warnings Not Ordered Systematically,"Within a given drug class, 1 agent may have a boxed warning, but others may not. The FDA should require the labels of same-class drugs without warnings to explain this omission."
  February 2011 ,Heartwire from Medscape,"Lots of Jantoven, other agents recalled",Upsher-Smith has expanded its recall from one lot to 16 lots of its Jantoven brand of warfarin sodium and has added lots of amlodipine and other drugs.
  February 2011 ,Medscape Medical News,Advantage to Radiation Plus Chemo in Hodgkin's Lymphoma,"Despite concerns about serious long-term effects, a meta-analysis found a clear advantage to giving both radiation and chemotherapy, compared with chemotherapy alone."
  February 2011 ,Medscape Medical News,Acid-Suppressive Medication Not Preferred Treatment Outside ICU,"Although acid-suppressive medication protected against nosocomial gastrointestinal tract bleeding, the number needed to treat to prevent 1 case was relatively high."
  February 2011 ,Medscape Medical News,PPI Use May Reduce Antifracture Efficacy of Bisphosphonate Treatment,"In an observational study, concurrent proton-pump inhibitor use was associated with a dose-dependent loss of protection against hip fracture treatment in elderly patients."
  February 2011 ,Reuters Health Information,NSAIDs May Worsen Pneumonia Outcomes,The benefits of nonsteroidal anti-inflammatory drugs in the treatment of lower respiratory tract infection may be outweighed by a delayed diagnosis of community-acquired pneumonia.
  February 2011 ,Medscape Medical News,Risk for Local Reaction to Fifth Dose of DTap Vaccine Higher With Arm Injection,Risk for a local reaction to the fifth dose of the diphtheria and tetanus toxoids and acellular pertussis vaccine is significantly higher when it is injected in the arm.
  February 2011 ,Medscape Medical News,FDA Adds 13 Drugs to Watch List,A drug's appearance on the FDA's watch list does not mean the agency has concluded it necessarily triggers the adverse event in question.
  February 2011 ,Heartwire from Medscape,New Rosiglitazone Label,"The new label has been changed to highlight the increased cardiovascular risks with the drug, noting that in a meta-analysis of 52 studies, most of which compared rosiglitazone with placebo, the drug was associated with a significantly increased risk of MI."
  April 2011 ,Medscape Medical News,Targeting 2 Pathways May Enhance Antitumor Activity,Combining therapies that target MEK and PI3K pathways has the potential to be more effective than either agent used alone.
  March 2011 ,WebMD Health News,Johnson & Johnson Recalls Even More Tylenol,One lot of Tylenol 8-Hour Extended Release caplets is the latest recall.
  March 2011 ,Medscape Medical News,An Antidepressant Reduces the Neurotoxicity of Oxaliplatin,New findings might have immediate clinical applications.
  March 2011 ,Medscape Medical News,BMD Decreases After Bariatric Surgery in Adolescents,"Within 2 years of surgery, bone mineral density levels do not decrease below average for age and sex, but if bone loss continues, it could have long-term consequences."
  March 2011 ,Medscape Medical News,Some Bottles of Citalopram Recalled Due to Mislabeling,"Certain bottles of the antidepressant citalopram are being recalled because they may actually contain finasteride, which is associated with possible severe side effects in pregnant women."
  March 2011 ,Heartwire from Medscape,ARB/ACE-Inhibitor Combo a Risk in Clinical Practice,Combining the two types of agent has increased the risk of renal dysfunction in clinical trials; the way the drugs are combined in clinical practice doesn't seem to avoid the problem.
  March 2011 ,Medscape Medical News,Risk Allele Flags Carbamazepine Hypersensitivity in Europeans,The researchers say adding association of HLA-A*3101 to carbamazepine reactions to the drug label should be considered.
  March 2011 ,Medscape Medical News,Fracture Warning Nixed for OTC Proton Pump Inhibitors,"Clinicians, however, should remember the possible risk of bone fracture if they advise patients to take an OTC proton pump inhibitor at higher doses or for longer periods than the label calls for."
  March 2011 ,Heartwire from Medscape,Adding Therapies to Aspirin Increases Risk of GI Bleeds,"New figures from a UK primary care database confirm that use of clopidogrel, warfarin, NSAIDs or high-dose corticosteroids on top of low-dose aspirin further increase the risk of gastrointestinal bleeding. And the study is one of few to quantify this risk, say the researchers."
  March 2011 ,Heartwire from Medscape,More Damning Data on Rosiglitazone,"A new meta-analysis of observational studies shows rosiglitazone to be associated with a higher risk of heart failure, MI, and death than pioglitazone. But despite having been taken off the market in Europe, the REMS restriction for rosiglitazone recommended by the US FDA last September has still not been finalized."
  March 2011 ,Medscape Medical News,American Regent Recalls 2 Lots of Sodium Chloride Injection ,Two lots of concentrated sodium chloride Injection are being voluntarily recalled because of particulate matter.
  March 2011 ,Medscape Medical News,Morphine/Naltrexone Combo Temporarily Withdrawn,"King Pharmaceuticals notes that Embeda, a combination of morphine and naltrexone, has been voluntarily withdrawn because ""a prespecified stability requirement was not met during routine testing."""
  March 2011 ,Medscape Medical News,Analysis Clarifies Drug Choices for People With Type 2 Diabetes,"In a new analysis, the evidence supports the choice of metformin as first-line therapy but also finds that the long-term benefits and harms of diabetes medications remain unclear."
  March 2011 ,Heartwire from Medscape,PPIs and Clopidogrel: New Theory May Explain CV Risk Signal,Authors of yet another analysis trying to get to the bottom of the real or perceived risk of combining clopidogrel with a proton-pump inhibitor have a new and provocative theory  as to just where the signal of increased events may be coming from.
  March 2011 ,Medscape Medical News,FDA: Avoid Use of Kaletra Oral Solution in Newborns,"Kaletra oral solution should be avoided in premature or full-term infants for the first 14 days after their due dates because of possible cardiac, renal, or respiratory problems."
  March 2011 ,Reuters Health Information,"Japan Halts Prevenar, ActHIB Vaccines After Four Children Die",Japan's health ministry has halted the use of vaccines made by Pfizer Inc and Sanofi-Aventis SA to prevent meningitis and pneumonia following the deaths of four children.
  March 2011 ,Medscape Medical News,Regular NSAID Use Linked to Erectile Dysfunction,Regular use of nonsteroidal anti-inflammatory drugs is associated with erectile dysfunction beyond what would be expected because of age and comorbidity.
  March 2011 ,Reuters Health Information,"When Birth Control Pills Are OTC, Patient Education Is Crucial","American women are crossing the border to buy over-the-counter birth control pills in Mexico, often without realizing when they have contraindications to the pills, researchers say."
  March 2011 ,WebMD Health News,Drug-Related Poisonings Land Many in ER,"Emergency departments treat an estimated 700,000  people yearly for drug poisonings, including many children."
  March 2011 ,Medscape Medical News,"FDA Pulls Unapproved Cold, Cough, Allergy Drugs From Market",The US Food and Drug Administration is requiring a halt to the manufacture and distribution of certain unapproved prescription oral agents. 
  May 2011 ,Medscape Medical News,Genetic Biomarkers May Predict Taxane-Induced Neuropathy,Several single-nucleotide polymorphisms associated with time to neuropathy in patients receiving paclitaxel therapy have been identified.
  May 2011 ,WebMD Health News,Correct Acetaminophen Dose Depends on Children's Weight,Infant drug labels should spell out dose.
  May 2011 ,Reuters Health Information,Zoledronic Acid Linked With Seizures in Case Reports,"Use of zoledronic acid for osteoporosis may occasionally be associated with seizures, according to three case reports published online April 20th in the Journal of Clinical Endocrinology & Metabolism."
  May 2011 ,Medscape Medical News,Vaccine Critics Claim Court Paid for Autism Cases,The study reports that 83 cases of vaccine-caused brain damage receiving federal compensation involved autism. Experts reply that shared symptoms do not make brain damage and autism identical.
  May 2011 ,Medscape Medical News,Absolute Risk for Femur Fracture Low With Bisphosphonates,"Although there is a high rate of bisphosphonate use among patients with atypical femur fractures, the absolute risk for such fractures is small enough to justify prescribing the drugs."
  May 2011 ,Medscape Medical News,Thyroid Drug Linked to Fracture Risk in Older Adults,"Among adults 70 years and older, current thyroid treatment was associated with significantly increased fracture risk, with a strong dose-response relationship."
  April 2011 ,Reuters Health Information,FDA: Safety Issue With Investigational Merck Hepatitis Drug,"U.S. drug reviewers highlighted safety issues with an experimental Merck & Co hepatitis drug, including anemia and reports of psychiatric problems, in documents released on Monday."
  April 2011 ,Medscape Medical News,FDA Adds Further Risk Information to Natalizumab Label ,The FDA identified a need to better define risk for progressive multifocal leukoencephalopathy and increased risk from concomitant immunosuppressants.
  April 2011 ,Medscape Medical News,Nine Drugs Added to FDA Watch List,A drug's appearance on the watch list does not mean the agency has determined that the drug necessarily causes the adverse event in question.
  April 2011 ,Reuters Health Information,More Evidence That Gastric Acid-Suppressive Drugs Raise Pneumonia Risk,"A new study shows that proton pump inhibitors are linked to a higher risk for community-acquired pneumonia, although the underlying mechanism remains unclear."
  April 2011 ,Medscape Medical News,Paracetamol Use in Pregnancy Linked to Childhood Asthma,A meta-analysis of studies shows a 21% increase in the risk for childhood asthma associated with use of paracetamol at any time during pregnancy.
  April 2011 ,Medscape Medical News,New vs Old Contraceptives Have Similar Gallbladder Disease Risk,"The risk for gallbladder disease is virtually the same with newer and older types of birth control pills, according to a comparative safety study."
  April 2011 ,Heartwire from Medscape,"Diet Drug Orlistat Linked to Kidney, Pancreas Injuries","A review of patients taking the diet drug orlistat over a seven-year period points to a 2% increase in acute kidney injuries within one year of patients starting the drug. Separately, safety-watchdog Public Citizen is once again petitioning the FDA to remove the drug from the market, citing adverse-event reports."
  April 2011 ,Heartwire from Medscape,EMA Warns of Hypersensitivity Reactions With Prasugrel,"The risks of hypersensitivity reactions are considered ""uncommon,"" affecting anywhere from 0.1% to 1.0% of patients treated with prasugrel."
  April 2011 ,Medscape Medical News,FDA Investigating Cancer Risk With Lenalidomide ,"Lenalidomide (Revlimid) may be associated with an increased risk for certain forms of hematologic malignancies, according to the FDA."
  April 2011 ,Medscape Medical News,"Ipilimumab Is for Community-Based Oncologists Too, Says Expert","It's the first-ever drug to be proven to extend survival in advanced melanoma, and it has life-threatening adverse events."
  April 2011 ,Medscape Medical News,Topical Benzocaine Associated With Methemoglobinemia,"Benzocaine sprays, gels, and liquids may cause methemoglobinemia, a rare but serious and potentially fatal condition."
  April 2011 ,Medscape Medical News,Ipilimumab Risk Strategy Released by FDA,A risk evaluation and mitigation strategy informs healthcare professionals of the serious risks associated with newly approved ipilimumab and recommended management strategies.
  April 2011 ,Medscape Medical News,Risks of Estrogen Therapy May Change With Longer Follow-Up,"At 10.7-year follow-up of postmenopausal women with prior hysterectomy and estrogen therapy (median, 5.9 years), breast cancer risk was still decreased and other shorter-term risks had lessened."
  April 2011 ,Medscape Medical News,Neck Circumference Linked to Perioperative Respiratory Events,High neck circumference could potentially be used to screen children for the risk for perioperative adverse respiratory events.
  June 2011 ,WebMD Health News,New Tylenol Recall Due to Musty Odor,"Johnson and Johnson recalls about 60,000 bottles of Tylenol Extra Strength Caplets."
  June 2011 ,Medscape Medical News,"Recall of Pain, Headache Meds Because of Label Mix-Up","Patients who accidentally take a tablet containing butalbital could experience sedation, lightheadedness, dizziness, and nausea, according to the US Food and Drug Administration."
  June 2011 ,Heartwire from Medscape,Study Raises Cancer-ARB Question Again,"In this latest study of diabetic patients treated with ARBs, candesartan was associated with a significant risk of cancer, while there was a trend toward an increased risk with telmisartan. The clinician who first sparked the ARB-cancer controversy says these new data should force the FDA to look again at patient-level data to assess the cancer risk with the drug class."
  June 2011 ,Medscape Medical News,Risperidone Recalled Due to Possible Contamination ,"Manufacturers of the antipsychotic risperidone have initiated a voluntary recall involving 40,000 bottles of the drug due to possible contamination with a wood preservative. "
  June 2011 ,Medscape Medical News,Acute Myeloid Leukemia Patients Overdosed With Cytarabine,"Patients being treated for acute myeloid leukemia receive up to 10 times more cytarabine than necessary, exposing them to excess toxicity but no added efficacy."
  June 2011 ,Heartwire from Medscape,Pioglitazone for 1 Year May Increase Risk of Bladder Cancer,"In the FDA's announcement today, the agency stated that information on the drug's label, as well as the patient medication guide, will be revised to include this new information."
  June 2011 ,Medscape Medical News,New Criteria Define Inappropriate Meds in Older Inpatients,STOPP criteria define potentially inappropriate medications and are significantly associated with avoidable adverse drug events leading to urgent hospitalization in older persons.
  June 2011 ,Medscape Medical News,Electronic Postdischarge Chart Prevents Adverse Drug Events,"Hospitalized patients who are receiving high-risk medications such as warfarin, analgesics, or benzodiazepines benefit from having pharmacists involved in discharge planning."
  June 2011 ,Medscape Medical News,Long-Term Doxorubicin Linked to Secondary Oral Cancers,Secondary cancers of the oral cavity appear to be associated with long-term treatment with pegylated liposomal doxorubicin in patients with recurrent ovarian cancer.
  June 2011 ,Heartwire from Medscape,French Regulators Suspend Pioglitazone Citing Cancer Risk,"The decision to yank the drug was made after a study requested by the drug regulatory authority, AFSSAPS, confirmed a small increase in bladder cancer among patients treated with the diabetes drug."
  June 2011 ,Medscape Medical News,Toxidromes: What Every Critical Care Nurse Should Know,"Critical care nurses need to be aware of toxidromes, a group of signs and symptoms and/or characteristic effects associated with exposure to a particular substance or class of substances."
  June 2011 ,Medscape Medical News,Drug Product Recall Due to Possible Penicillin Contamination ,Concerns over potential cross-contamination of nonpenicillin drug products with penicillin have resulted in a nationwide recall of multiple repackaged products. 
  June 2011 ,Heartwire from Medscape,FDA Review Concludes: No Cancer Risk With ARBs,"An FDA review launched in the wake of a controversial 2010 meta-analysis has concluded that the drugs do not pose a cancer risk to patients. The FDA says it conducted a much larger, more comprehensive review of the data to reach its reassuring conclusions. Not everyone, however, is satisfied."
  May 2011 ,Medscape Medical News,Sulfonamides and Nitrofurantoins OK to Use During Pregnancy,An opinion statement says that most antibiotics are safe to use during pregnancy and that pregnant women should not be denied appropriate treatment of infections.
  May 2011 ,Medscape Medical News,Adverse Device-Related Events Are Frequent in Children,Adverse outcomes from the use of medical devices in children are frequent but underrecognized.
  May 2011 ,Medscape Medical News,Daily Azithromycin Reduces Acute Exacerbations of COPD,A systematic review suggests that antibiotic exposure prenatally or in early childhood may slightly increase the risk for childhood asthma.
  May 2011 ,Medscape Medical News,Antibiotics May Slightly Increase Risk for Childhood Asthma,"In men with chronic obstructive pulmonary disease, use of short- and long-acting inhaled anticholinergic medications is associated with an increased risk for acute urinary retention."
  May 2011 ,Medscape Medical News,Inhaled Anticholinergics Linked to Acute Urinary Retention,The product may be associated with an increased risk for necrotizing enterocolitis; healthcare professionals should stop administering the product to premature infants.
  May 2011 ,Medscape Medical News,FDA Warns Against Use of SimplyThick in Premature Infants,"Results of this study have possible suggestions for long-term aspirin use in the prevention of chronic disease, as aspirin dose appears to be more important than aspirin duration."
  August 2011 ,Heartwire from Medscape,UK's NICE Wants More Cost-Effectiveness Data on Dabigatran,NICE is requesting further cost-effectiveness analyses comparing dabigatran with warfarin using different effectiveness data and different scenarios for reflecting the cost of warfarin monitoring.
  August 2011 ,Heartwire from Medscape,Deaths Prompt Dabigatran Safety Advisory in Japan,"According to Boehringer Ingelheim, treatment with Prazaxa, as it is known in Japan, could not be completely ruled out as a cause of death in five patients, one of whom had kidney failure (a contraindication) and four of whom were aged over 80."
  August 2011 ,Medscape Medical News,Jury Still Out on Somatropin and Increased Risk for Death,The FDA advises clinicians to still prescribe recombinant human growth hormone even as the agency continues to weigh a French study that linked the therapy to a higher risk for death.
  August 2011 ,Heartwire from Medscape,New Pioglitazone Label Highlights Bladder-Cancer Risk,The updated label states that pioglitazone should not be started in patients with active bladder cancer and should be used with caution in patients with a prior history of bladder cancer.
  August 2011 ,Heartwire from Medscape,Caution Needed With Dabigatran (Pradaxa),"Caution must be exercised when prescribing the new anticoagulant dabigatran to prevent stroke in atrial-fibrillation patients who are elderly and frail, say doctors."
  August 2011 ,Medscape Medical News,FDA Warns Against Fluconazole (Diflucan) in Early Pregnancy,The agency says long-term use of fluconazole (Diflucan) in high doses in the first trimester may be associated with birth defects.
  July 2011 ,Medscape Medical News,FDA Warns Against Counterfeit Morning-After Pill,"An unapproved morning-after pill called Evital has not been shown to be safe or effective in preventing pregnancy, the FDA warns. "
  July 2011 ,Medscape Medical News,FDA: Avoid Methylene Blue or Linezolid With Serotonergics,The FDA warns that coadministration of either methylene blue or linezolid  and certain serotonergic agents can lead to an interaction triggering serotonin syndrome.
  July 2011 ,Heartwire from Medscape,EMA Updates on Pioglitazone and Varenicline,"The European drug regulator is recommending a label change for one drug, and a stay-the-course message for the second."
  July 2011 ,Medscape Medical News,"FDA Studying Link Between Bisphosphonates, Esophageal Cancer",The agency continues to review studies that reach different conclusions on the possible association between esophageal cancer and the widely prescribed drugs for osteoporosis.
  July 2011 ,Medscape Medical News,Chemo Toxicity May Tip Scales in Advanced Hodgkin's Lymphoma,Overall survival nearly evened out in a clinical trial comparing 2 chemotherapy regimens; adverse events might be a deciding factor in choosing one or the other.
  July 2011 ,Medscape Medical News,Etravirine Shows Fewer Neuropsychiatric AEs Than Efavirenz ,"Compared with efavirenz, etravirine appears to be associated with fewer neuropsychiatric adverse events."
  July 2011 ,Medscape Medical News,Single Lot of Calcium Gluconate Injection Recalled,"American Regent is voluntarily recalling its calcium gluconate injection, USP, 10% 100 mL pharmacy bulk package, lot number 1006, because some vials may contain silicone particles."
  July 2011 ,Medscape Medical News,Benefits of Ovarian Suppression During Breast Cancer Chemo,"The rate of early menopause is significantly reduced, but any fertility benefit is unknown."
  July 2011 ,Medscape Medical News,New  FDA Watch List Has Drug Making Fifth Straight Appearance,"Several of the potential signals in 2010 of serious risks for dronedarone, an  antiarrhythmic, have been followed by label changes."
  July 2011 ,Medscape Medical News,H1N1 Flu Vaccine Not Linked to Guillain-Barré Syndrome,"In a case-control study, the risk for Guillain-Barré syndrome was not increased after pandemic influenza vaccine, but the upper limit did not exclude a potential increase in risk up to 2.7-fold."
  July 2011 ,Reuters Health Information,"Thyroid Effects of Generic, Brand-Name Amiodarone Similar","The anti-arrhythmic drug amiodarone is linked with similar rates of thyroid effects whether patients take the brand-name drug or a generic, Canadian research shows."
  July 2011 ,Medscape Medical News,Lower Concentration for Oseltamivir Oral Suspension ,The influenza drug will become available in the new 6 mg/mL formulation this month. The old 12 mg/mL version will remain on the market until supplies run out.
  July 2011 ,Medscape Medical News,FDA Reminds Clinicians About Risks With Belatacept,The manufacturer was required to inform clinicians and patients about the risk for posttransplant lymphoproliferative disorder and progressive multifocal leukoencephalopathy when the FDA okayed the kidney transplant drug.
  July 2011 ,Medscape Medical News,Pediatric Collaborative May Reduce Adverse Drug Events,A pediatric collaborative addressing systems of medication delivery was associated with lower rates of adverse drug events at participating institutions. 
  September 2011 ,Heartwire from Medscape,Beware Bleeding With SSRIs and Antiplatelets,"Selective serotonin-reuptake inhibitor antidepressants appear to increase the risk of bleeding in patients taking antiplatelet agents, a new study suggests."
  September 2011 ,Medscape Medical News,IMRT Reduces GI and GU Toxicity in Prostate Cancer,Men treated with the newer technology had fewer late bowel and rectal complications than those treated with 3D-conformal radiation therapy.
  September 2011 ,Medscape Medical News,5-Year Data: Hypofractionated Radiation for Prostate Cancer,"The newer technology reduces treatment time by 2.5 weeks, but late bladder toxicity is a concern."
  September 2011 ,Medscape Medical News,FDA Still 'Concerned' About Drospirenone VTE Risk,The US Food and Drug Administration remains concerned about drospirenone-containing oral contraceptives and increased risk for venous thromboembolism.
  September 2011 ,Heartwire from Medscape,Europeans Looking Again at Orlistat and Liver Injury,"The European Medicines Agency says that it has started a review of orlistat-containing medicines to determine whether the ""very rare cases of hepatic injury have an impact on their benefit/risk profile and conditions of use."""
  September 2011 ,Heartwire from Medscape,French Judges Charge Servier Head in Mediator Scandal,French magistrates allege that Jacques Servier engaged in dishonest practices and deception over the drug's quality and falsely obtained authorization to sell the controversial diabetes drug.
  September 2011 ,Heartwire from Medscape,EMA Recommends Restricting Use of Dronedarone,"The EMA committee states that because of the increased risk of liver, lung, and cardiovascular adverse events, dronedarone ""should only be prescribed after alternative treatment options have been considered."""
  September 2011 ,Medscape Medical News,Qualitest Oral Contraceptives Recalled,A packaging error has prompted generic drugmaker Qualitest Pharmaceuticals to recall multiple lots of oral contraceptives. 
  September 2011 ,Medscape Medical News,"Ondansetron Linked to Arrhythmias, FDA Warns",The FDA is revising the drug’s label to warn that patients with congenital long QT syndrome may run the risk for torsades de pointes.
  September 2011 ,Medscape Medical News,Nonaspirin NSAID Use Linked to Risk for Renal Cell Cancer,Data from 2 prospective studies show an association between long-term use of nonaspirin anti-inflammatory drugs and the risk for renal cell cancer.
  September 2011 ,Medscape Medical News,"Clarify Duration of Bisphosphonate Use, FDA Panel Says",An FDA panel has advised the FDA to be more specific about the duration of bisphosphonate use for the treatment of osteoporosis.
  September 2011 ,Medscape Medical News,Adverse Drug Reactions Often Preventable,A meta-analysis shows that many adverse drug reactions that occur in the hospital and during emergency care are preventable.
  September 2011 ,Medscape Medical News,Incidence of Thromboembolic Events With Cisplatin Too High,"The incidence of thromboembolic events in patients receiving cisplatin-based chemotherapy is unacceptably high, a retrospective analysis concludes."
  September 2011 ,Reuters Health Information,HCV Therapy Can Cause Mild Depression to Spike,"Depressive symptoms may worsen during antiviral therapy among patients with hepatitis C virus, and notable changes in patients with subclinical depressive symptoms at baseline may be of most concern."
  September 2011 ,Medscape Medical News,NSAIDs in Early Pregnancy Linked to Risk for Miscarriage, A case-control study shows a 2.4-fold increased risk for miscarriage in women who took any type and dosage of nonaspirin nonsteroidal anti inflammatory drugs in early pregnancy.
  September 2011 ,Medscape Medical News,Atypical Antipsychotic Linked to Life-Threatening Reactions,"The FDA has issued a warning about the atypical antipsychotic Saphris, which has been linked to serious allergic reactions. "
  August 2011 ,Medscape Medical News,"Few Adverse Events Linked to Vaccines, IOM Panel Says","The expert committee also reported that scientific evidence favors rejecting a causal relationship between autism and the measles, mumps, and rubella vaccine."
  August 2011 ,Medscape Medical News,Macrolide Useful in COPD But May Cause Hearing Loss,A macrolide antibiotic given daily for 1 year in addition to usual treatment reduced chronic obstructive pulmonary disease exacerbations and improved quality of life but caused hearing decrements.
  August 2011 ,Medscape Medical News,Biologics for Psoriasis May Not Raise Cardiovascular Risk,"Use of certain biologic therapies for psoriasis was not associated with a significant difference in rate of major adverse cardiovascular events vs placebo, but the study may have been underpowered."
  August 2011 ,Medscape Medical News,High Doses of SSRI Linked to Abnormal Heart Rhythm,The SSRI citalopram should not be used in doses higher than 40 mg/day because of concerns that it may cause abnormal and potentially fatal changes in heart rhythm. 
  November 2011 ,Heartwire from Medscape,Dabigatran: 260 Fatal Bleeds Since Approval Worldwide,"Events occurred from March 2008 to October 31, 2011. European regulators are monitoring the issue and say that changes to the drug's current usage instructions 'adequately manage the risk of bleeding.'"
  November 2011 ,News Alerts,Buflomedil-Containing Drugs May Be Suspended in EU,The European Medicines Agency is recommending suspension of all buflomedil-containing medicines.
  November 2011 ,Heartwire from Medscape,Dronedarone a Hazard in High Risk Patients With Permanent AF,"The antiarrhythmic, approved for paroxysmal or intermittent AF, upped the risk of stroke, heart failure, and arrhythmic death in patients with permanent AF and other CV risk factors."
  November 2011 ,Medscape Medical News,ASCO Updates Guidelines on Antiemetics,New recommendations for preventing vomiting and nausea caused by cancer treatments are published.
  November 2011 ,Medscape Medical News,HIV Patients on HAART Have a Plethora of Ocular Diseases,"The prevalence of cataracts among HIV-positive patients receiving HAART is 10 times higher than in the rest of the American population, and the cataracts develop at a much younger age."
  October 2011 ,Heartwire from Medscape,Renal-Assessment Update Issued for Dabigatran,Boehringer Ingelheim has agreed with the European Medicines Agencies to issue an update to the labeling for dabigatran.
  October 2011 ,Medscape Medical News,FDA Provides Update on Drospirenone VTE Risk,"Further analysis of an FDA-funded study provides more evidence that drospirenone-containing oral contraceptives increase risk for venous thromboembolism, the agency says. "
  October 2011 ,Medscape Medical News,Thyroid Testing Urged for Cancer Patients On Newer Therapies,"Newer targeted therapies and immunotherapies are associated with thyroid dysfunction, which can be mistaken for drug toxicity and lead to unnecessary dosage reductions."
  October 2011 ,Medscape Medical News,Sepsis Drug Xigris Pulled From Worldwide Market,"Physicians should stop ongoing treatment with the drug now that it has failed a new efficacy test, according to the FDA."
  October 2011 ,Medscape Medical News,MS Relapse Seen After Natalizumab Drug Holiday ,"The risks of natalizumab treatment interruption, even with an alternative immunomodulatory therapy, appear to outweigh the theoretical benefits, researchers say. "
  October 2011 ,Medscape Medical News,"FDA Updates Warnings on Methylene Blue, Linezolid, and Serotonergics ","The agency now says that combining methylene blue or linezolid with SSRIs and SNRIs can trigger serotonin syndrome, but this risk may not apply to other serotonergic agents."
  October 2011 ,Heartwire from Medscape,"EMA Reviewing Safety of NSAIDs, Clarifies on Pioglitazone","The EMA has launched a new review of the cardiovascular safety of NSAIDs, while also clarifying a previous opinion on the use of the antidiabetic agent pioglitazone and the risk of bladder of cancer."
  October 2011 ,Heartwire from Medscape,EMA Review Concludes: No Cancer Risk With ARBs,"The European Medicines Agency ""concludes that benefit/risk balance of angiotensin-II-receptor antagonists remains positive,"" a press release from the agency states today."
  October 2011 ,Medscape Medical News,Erectile Dysfunction Common With Colorectal Cancer Treatment,"A small survey found that most men developed erectile dysfunction after their colorectal cancer treatment, and that it caused ""profound distress."""
  October 2011 ,Heartwire from Medscape,Dabigatran: Australia Issues Bleeding Warning,"The Australian regulatory authority has issued a ""safety advisory"" on the new oral anticoagulant dabigatran because of an increase in the number of bleeding-related adverse events reports received since it was approved for use in AF patients. "
  October 2011 ,Medscape Medical News,Long-Term Pulmonary Toxicity From Breast Irradiation,There is good news from the first study -- a randomized trial -- reporting long-term toxicity outcomes after breast cancer therapy.
  October 2011 ,Heartwire from Medscape,Fuel to the Fire or Flame Retardant? More on ARB Use/Cancer,"The use of angiotensin-receptor blockers or ACE inhibitors is not associated with a significantly increased risk of cancer, according to a new meta-analysis. The findings add yet another twist to the debate over whether or not the antihypertensive medications are associated with increased cancer incidence."
  October 2011 ,Medscape Medical News,Reassuring Findings on Anticholinergics in Dementia Patients,New research suggests that medications with mild anticholinergic effects don't cause further cognitive decline in patients with Alzheimer's disease.
  September 2011 ,Heartwire from Medscape,Clopidogrel Hypersensitivity Treated With Steroids a Success,"A new study has confirmed that virtually all patients with allergic reactions to clopidogrel respond favorably to a three-week course of prednisone, without having to interrupt antiplatelet therapy."
  September 2011 ,Heartwire from Medscape,More Data Reignite Debate on ARB-Lung Cancer Risk ,"A new study, this time in kidney-transplant recipients, has found that those who took ACE inhibitors or angiotensin-receptor blockers had an increased risk of respiratory tumors if they also had a history of smoking. Some dismiss the findings, but others say they warrant further investigation."
  January 2012 ,Heartwire from Medscape,Contaminated Cardiac Drugs Kill More Than 100 in Pakistan,More than 100 people have died in Pakistan and hundreds more have been hospitalized after having received contaminated cardiac drugs.
  January 2012 ,Medscape Medical News,Most Adverse Events in Hospitals Go Unreported,"The main reason for incidents falling through the cracks is that staff does not perceive the event as reportable, says a new study from HHS. Nurses did most of the reporting that occurred."
  January 2012 ,Medscape Medical News,Pharmacists' Role Critical to Patient Safety,Pharmacists play a key role in reducing adverse drug events and improving patient safety during care transitions.
  December 2011 ,News Alerts,FDA Warns About Potential Mix-Ups With Durezol and Durasal,"Because the product names are similar, a pharmacist accidentally dispensed the wart remover instead of the prescription eye drops to a patient, leading to a serious injury."
  December 2011 ,Heartwire from Medscape,"Adverse Events When Aliskiren Added to ACE, ARB Therapy","Data and safety monitors for ALTITUDE noted that patients in the trial taking aliskiren instead of placebo on top of ACE or ARB therapy experienced an increased incidence of nonfatal stroke, renal complications, hyperkalemia, and hypotension."
  December 2011 ,News Alerts,FDA to Study Death of Patient After First Fingolimod Dose,The agency said it still believes the benefits of the drug to treat relapsing forms of multiple sclerosis outweigh potential risks. The cause of the patient's death remains to be determined.
  December 2011 ,News Alerts,FDA Revises Dose for Simvastatin With Amiodarone,The agency is raising the allowed dose for simvastatin in combination with the cardiac drug back to 20 mg after mistakenly lowering it to 10 mg in June.
  December 2011 ,News Alerts,Riata ICD Lead 'Alert' Is Now a Class I Recall,"The US FDA has designated a recent physician advisory letter relating to St Jude Medical's Riata family of ICD leads as a class I recall, the most serious. The letter, issued last month, warned doctors that more leads than it first thought were affected by a problem related to insulation failure."
  December 2011 ,Medscape Medical News,American Dental Association Updates Osteonecrosis Guidelines,"Shifting away from an emphasis on intravenous bisphosphonates, the American Dental Association Council on Scientific Affairs points to a dose-response effect with antiresorptive therapy."
  December 2011 ,Medscape Medical News,Baseline 'Bother' Predicts Quitting Aromatase Inhibitors,What is associated with postmenopausal women discontinuing aromatase inhibitors?
  December 2011 ,Medscape Medical News,New Evidence Addresses ADHD Meds and Adult CVD Risk,"A large observational study provides reassuring news on the safety of medications for attention-deficit hyperactivity disorder in middle-aged adults, researchers say."
  December 2011 ,News Alerts,FDA Investigating Serious Bleeding Events With Dabigatran,The agency wants to know whether bleeding events are occurring more commonly than would be expected based on data from the RE-LY trial.
  December 2011 ,News Alerts,FDA Relaxes REMS Requirements on 2 Low Platelet Drugs,"The US FDA has dropped a requirement that prescribers and patients enroll in a monitoring network to use Nplate and Promacta, among other changes. "
  December 2011 ,Medscape Medical News,Don't Use Vemurafenib in Earlier-Stage Melanomas,Could RAF inhibitors cause other cancers over time?
  November 2011 ,Medscape Medical News,Tenofovir Associated With Nonreversible Kidney Disease,Tenofovir for treating HIV is associated with increased risk for kidney disease; this risk does not appear to be reversible after discontinuation.
  November 2011 ,Medscape Medical News,4 Drugs Cause Most Adverse-Event Hospital Stays for Seniors,"Most emergency hospitalizations for seniors caused by adverse drug events involve a handful of anticoagulants and diabetes medications, according to a new study."
  November 2011 ,Heartwire from Medscape,Merck Vioxx Payout in US Approaches $1 Billion,"Concluding a long-running investigation into promotion of its COX-2 inhibitor, rofecoxib, Merck has agreed to pay out almost $1 billion to the US federal government and most states. But the company still does not admit any wrongdoing with regard to the cardiovascular safety of the drug."
  November 2011 ,Medscape Medical News,Joint Supplements for Aromatase Inhibitor Adverse Effects,"In combination, glucosamine and chondroitin appear to ease joint pain and improve function in breast cancer patients taking aromatase inhibitors. "
  November 2011 ,Medscape Medical News,Adverse CNS Effects of HCV Treatment Discourage Adherence,"Medications for hepatitis C virus (HCV) can exacerbate cognitive deficits that are already seen in patients with chronic liver disease, and pose a risk to treatment adherence."
  November 2011 ,Heartwire from Medscape,Transapical TAVI Stopped Due to Adverse Events: STACCATO,"A study comparing the transapical approach for transcatheter aortic-valve implantation against conventional aortic-valve replacement surgery was stopped early due to an increase in adverse events, including an increased risk of major stroke and severe paravalvular leakage, in elderly patients eligible for surgery."
  March 2012 ,News Alerts,EMA Recommends New Warnings on Osteoporosis Drug ,"The CHMP has confirmed a positive benefit-risk balance for strontium ranelate, but recommends new contraindications and revised warnings. "
  March 2012 ,Medscape Medical News,New Report: Cancer and CVD After Radiation Therapy ,Radiation therapy saves lives but might induce diseases that threaten once again to take them away.
  March 2012 ,Medscape Medical News,"Steroids Linked to Suicide, Neuropsychiatric Disorders","Glucocorticoids, which are widely used to treat asthma, rheumatoid arthritis, and other autoimmune diseases, have been linked to a significant risk for suicide, mania, delirium, and depression."
  March 2012 ,News Alerts,FDA: New Risks for Statins With HIV/HCV Protease Inhibitors,"Interactions between 4 statins and protease inhibitors can increase statin exposure and cause muscle injury, including a form that can lead to kidney failure."
  March 2012 ,Medscape Medical News,New Option for Common Capecitabine Adverse Effect?,Hand-foot syndrome occurs in many colorectal cancer patients treated with this chemotherapy. Can an anti-inflammatory help?
  February 2012 ,Reuters Health Information,Phosphate Enemas May Be Deadly in Elderly: Report,"Sodium phosphate enemas may cause older people to suffer kidney failure or even die, a new report suggests."
  February 2012 ,Medscape Medical News,Some FDA Warnings Have Minimal Effect ,"A new study finds that many US Food and Drug Administration drug risk communications have a delayed effect, unintended consequences, or no effect."
  February 2012 ,Heartwire from Medscape,Over 1300 Deaths in Mediator Scandal in France ,"The number of deaths attributable to heart-valve insufficiency as a result of the use of benfluorex in France is likely more than double that previously thought, a new investigation finds."
  February 2012 ,Medscape Medical News,Chemotherapy During Pregnancy Appears Safe for Offspring ,"Children exposed to chemotherapy during the prenatal period appear to develop as well as those in the general population, without increased cardiac or neurologic morbidity. "
  February 2012 ,News Alerts,"Boceprevir May Make Some HIV Drugs Less Effective, FDA Warns","The FDA warns clinicians and patients about ""important"" drug interactions between boceprevir and ritonavir-boosted anti-HIV protease inhibitors."
  February 2012 ,Medscape Medical News,"Fatal Adverse Events with Pazopanib, Sorafenib, Sunitinib","These targeted therapies represent a major step forward in the treatment of cancer, but are associated with fatal adverse events. "
  February 2012 ,Medscape Medical News,Bisphosphonates Raise Contralateral Atypical Fracture Risk,A study of atypical femur fractures shows an increase in contralateral fractures in patients continuing bisphosphonates.
  February 2012 ,News Alerts,Proton Pump Inhibitors Linked to C difficile Diarrhea,"The FDA is warning that PPIs may be associated with a higher risk for Clostridium difficile-associated diarrhea, a persistent illness that comes with abdominal pain and fever."
  February 2012 ,Medscape Medical News,FDA Panel Raises Concerns Over ADHD Drug Labeling,The FDA's Pediatric Advisory Committee has recommended labeling changes for an attention-deficit/hyperactivity disorder drug and discussed adverse effects. 
  February 2012 ,Medscape Medical News,FDA Says Tamsulosin Safe in Pediatric Patients,The panel concurred with the FDA that tamsulosin can return to routine safety monitoring. 
  February 2012 ,Medscape Medical News,"EBRT More Costly, Toxic Than Other Prostate Cancer Therapies",External-beam radiation therapy (EBRT) for prostate cancer is more costly and more toxic than either prostatectomy or brachytherapy. 
  January 2012 ,Medscape Medical News,FDA Panel Says Omalizumab Safe in Pediatric Patients,The Pediatric Advisory Committee Panel has recommended a return to routine monitoring in patients aged 6 to 11 years who are receiving omalizumab.
  January 2012 ,Medscape Medical News,HPV Vaccine Policy: At Odds With Evidence-Based Medicine?,"According to a new study, there is a major discrepancy in claims regarding the safety and efficacy of the human papillomavirus (HPV) vaccines."
  January 2012 ,Medscape Medical News,"Oxaliplatin Has Few Benefits, High Toxicity in Rectal Cancer",Long-term results from the French ACCORD 12 trial show that adding oxaliplatin to capecitabine plus radiotherapy does not improve survival in rectal cancer.
  January 2012 ,Medscape Medical News,IMRT Slows Radiation-Related Osteoradionecrosis,"Osteoradionecrosis appears delayed with intensity-modulated radiation therapy (IMRT); however, some complications still occur."
  May 2012 ,Medscape Medical News,Are Calcium Channel Blockers Radioprotective?,"Antihypertensive medications might block late radiotherapy toxicity, but there are still many questions."
  May 2012 ,News Alerts,FDA Updates Safety Information for Lenalidomide,"In an update to their ongoing review, the FDA has added safety information to lenalidomide's labeling to inform patients and physicians of an increased risk for secondary cancers. "
  May 2012 ,Medscape Medical News,New Antivirals Show Poor Safety in HCV With Cirrhosis ,"Two direct-acting antiviral drugs have poor safety profiles in compensated cirrhotic patients with hepatitis C virus (HCV), including many serious adverse events, but good efficacy."
  April 2012 ,News Alerts,"Boceprevir Not Recommended With Certain HIV Drugs, FDA Says","Combining the hepatitis C drug with HIV drugs boosted by ritonavir for coinfected patients can lessen the effectiveness of the drugs, according to the agency."
  April 2012 ,Reuters Health Information,"Race and Perioperative Pain, Opioid Adverse Events in Children","Children of different races have unequal burdens of perioperative pain and risks of opioid-related adverse effects, according to a report today in Pediatrics."
  April 2012 ,Reuters Health Information,Telaprevir May Cause Severe Cutaneous Eruptions,"The antiviral agent telaprevir (Incivek) has been associated with severe cutaneous eruptions, including the DRESS syndrome (drug reaction with eosinophilia and systemic symptoms)."
  April 2012 ,News Alerts,FDA Issues Warning on Fentanyl Patches,"The new warning reiterates appropriate use of the patches to prevent life-threatening accidental exposure to the drug, particularly in children."
  April 2012 ,Medscape Medical News,Benefits and Risks of Trastuzumab in Breast Cancer,"A systematic review shows that trastuzumab significantly increases survival in women with HER2-positive breast cancer, but also puts them at risk for heart problems."
  April 2012 ,Medscape Medical News,FDA Puts 16 Drugs on Watch List,"Homicidal thoughts are a potential issue for 1 of the 16 drugs added to the agency watch list, but a drug's appearance does not mean the FDA has concluded that it causes the adverse event in question."
  April 2012 ,News Alerts,PML Reported in MS Patient on Fingolimod,Novartis today reported a case of PML in a multiple sclerosis patient taking fingolimod.
  April 2012 ,News Alerts,FDA Announces Safety Label Changes to Finasteride ,Updated labels for finasteride (1 mg and 5 mg) will warn that some sexual adverse effects may linger after the drugs are discontinued.
  April 2012 ,News Alerts,FDA Adds VTE Risk to Drospirenone Label ,Patients using oral bisphosphonates for the first time may be at increased risk of developing scleritis and uveitis. 
  April 2012 ,Medscape Medical News,Bisphosphonates May Increase Risk for Uveitis and Scleritis,"If the FDA follows the recommendations, drug companies will have to either conduct phase 2 to 3 trials or do meta-analyses that rule out excess cardiovascular risk for new obesity drugs that do not have a signal for cardiovascular risk. Advisors voted 17 to 6 in favor of a cardiovascular-safety benchmark that equals the one for diabetes drugs."
  March 2012 ,Heartwire from Medscape,'Safe' Obesity Drugs Need to Prove Absence of CV Risk,"In day one of a two-day meeting, members of the FDA Endocrinologic and Metabolic Drugs Advisory Committee heard from experts in obesity, diabetes, cardiology, and statistics. Later today, the panel will vote on whether obesity drugs with no cardiovascular risk signal still need to rule out excess cardiovascular risk."
  March 2012 ,Heartwire from Medscape,FDA Committee Grapples With CV Risks in Obesity Drugs,Treatment-induced menopausal symptoms in breast cancer patients can be considerably ameliorated with cognitive behavioral therapy and physical exercise.
  March 2012 ,Medscape Medical News,Treatment-Induced Menopause Helped by Nondrug Therapies,"Citalopram, a commonly used SSRI, should not be used in doses greater than 20 mg/day in adults over 60 due to an increased risk of QT prolongation."
  March 2012 ,News Alerts,"Lower Citalopram Dose Needed in Older Patients, FDA Warns",A hallmark of the toxic effects seems to be cutaneous necrosis on the ears and the appearance of autoantibodies.
  March 2012 ,Medscape Medical News,Levamisole-Laced Cocaine May Unmask Autoimmune Process,A study shows that using more dental sedatives increases the rate of complications in pediatric dental patients.
  March 2012 ,Medscape Medical News,Added Complications With More Dental Sedatives for Children,Black patients are at greatest risk for ventilatory-assisted hospitalization.
  July 2012 ,Medscape Medical News,Prostate Cancer AEs Persist 5 to 10 Years After Treatment,"Average sexual and urinary dysfunction is still 'very poor' up to 10 years after treatment, a study finds."
  July 2012 ,News Alerts,Lot of Vecuronium Bromide Under Recall,The US Food and Drug Administration has announced a voluntary manufacturer recall of one lot of injectable vecuronium bromide.
  July 2012 ,Medscape Medical News,Antipsychotics Linked to Gestational Diabetes,"Women who use antipsychotics during pregnancy may be at risk of developing gestational diabetes, and their babies may be at risk for increased head circumference."
  June 2012 ,Medscape Medical News,Voluntary Drug Event Reporting Systems Woefully Lacking,Health systems need to move beyond methods for adverse drug event detection that rely primarily on voluntary reporting and should use several different methods to detect multiple types of events.
  June 2012 ,News Alerts,FDA Issues Update on QT Prolongation Risk With Ondansetron ,"The 32-mg single intravenous dose of ondansetron should be avoided, as it may cause QT interval prolongation and could lead to a potentially fatal heart arrhythmia."
  June 2012 ,Heartwire from Medscape,Olmesartan Linked to Rare Serious GI Side Effects,A report from the Mayo Clinic suggests some patients on the hypertension drug olmesartan are at risk for severe intestinal inflammation.
  June 2012 ,Medscape Medical News,Vitamin B12 Deficiency With Metformin Linked to Neuropathy,"In patients with type 2 diabetes taking metformin, vitamin B12 deficiency is linked to increased peripheral neuropathy. "
  June 2012 ,Heartwire from Medscape,Acceptable Thrombosis Risk With Hormonal Contraceptives,"In the largest-ever study to look at arterial thrombotic complications as a result of the use of hormonal contraception, Danish researchers find the risks are, for the most part, acceptable, given the benefits of these products."
  June 2012 ,Medscape Medical News,Glucarpidase for Methotrexate Toxicity Oncologic Emergency,Cancer patients on high-dose methotrexate who develop renal impairment and acute toxicity can be rescued with a single dose of the new agent.
  June 2012 ,Heartwire from Medscape,Statins Linked to Fatigue in Randomized Study,Moderate doses of both simvastatin and pravastatin were associated with tiredness and exertional fatigue in what is thought to be the first randomized study to look at such adverse effects with statins.
  June 2012 ,Medscape Medical News,"Duloxetine Useful in Chemo Neuropathy, But Avoid ALC","The antidepressant alleviated chemotherapy-induced neuropathy in what is described at a practice-changing trial, but patients with breast cancer should avoid acetyl-L-carnitine (ALC) supplements."
  June 2012 ,News Alerts,Contraceptives Recalled Because of Packaging Flaw,"The US Food and Drug Administration is notifying healthcare professionals of a voluntary recall of levonorgestrel and ethinyl estradiol tablets (Introvale, Sandoz) because of a packaging flaw."
  May 2012 ,Heartwire from Medscape,EU Medicines Agency Launches Adverse Drug Event Web Site,"In a move aimed at improving transparency, suspected side effects with any medicine approved via the centralized EU approvals procedure can now be searched on a new website."
  May 2012 ,Medscape Medical News,Oral Methylnaltrexone for Opioid-Induced Constipation,DDW 2012: Half the patients responded to daily dosing.
  May 2012 ,Medscape Medical News,Genetic Markers Linked to Prostate Radiation Toxicity,Identifying susceptibility markers could guide therapy in the future.
  May 2012 ,Medscape Medical News,Lack of Awareness of Late Drug Effects in Cancer Survivors ,Very few primary care physicians are aware of all the main long-term complications from 4 commonly used chemotherapies.
  May 2012 ,Medscape Medical News,'One-Two Punch' for Advanced Melanoma Is Less Toxic,Skin toxicities are a concern with new treatments for metastatic melanoma.
  May 2012 ,Medscape Medical News,Olanzapine Reduces Breakthrough Chemo-Induced Emesis,"In the first study of its kind, olanzapine was significantly more effective than metoclopramide in stopping breakthrough chemotherapy-induced nausea and vomiting."
  May 2012 ,News Alerts,FDA to Review CV Risk With Azithromycin,"In an observational study, during a five-day course of azithromycin therapy, patients had a small, increased chance of dying from sudden cardiac death compared with patients taking amoxicillin. The risk of death was higher among patients with the most baseline cardiovascular risk factors."
  September 2012 ,News Alerts,FDA Warns of Burns From Topical Pain Relievers,The US Food and Drug Administration warns of the potential for burns with over-the-counter topical joint and muscle pain relievers.
  September 2012 ,Medscape Medical News,Documented CNS Infections Accompanied Natalizumab Use,At least 17 patients taking natalizumab have experienced serious herpes simplex or varicella zoster infections since November 2004. 
  September 2012 ,Medscape Medical News,Public Citizen Sues FDA Over Safety of High-Dose Donepezil,A consumer watchdog group charges the FDA with not acting on its May 2011 petition to pull the 23-mg dose of donepezil from the market because of safety concerns.
  September 2012 ,Medscape Medical News,Aloe Vera Reduces Severity of Dermatitis After Radiotherapy,"The prophylactic use of topical aloe vera, an ancient herbal remedy, significantly reduces the severity of radiation-induced dermatitis."
  August 2012 ,Medscape Medical News,Risk for Heart Failure With Trastuzumab Higher Than Believed,Clinical trials have shown that anthracyclines and trastuzumab together increased the risk for heart failure; that risk appears to be even higher in a real-world setting.
  August 2012 ,Medscape Medical News,Olanzapine Activates Food Reward Area of the Brain,"A new imaging study shows that olanzapine can trigger anticipatory responses to food in specific areas of the brain after just 1 week of treatment, contributing to significant weight gain."
  August 2012 ,Reuters Health Information,Antiepilepsy Drug Rufinamide Tied to Weight Loss,"Nearly half of the patients taking rufinamide for epilepsy in a new case series developed clinically significant weight loss, according to French researchers."
  August 2012 ,Medscape Medical News,New Anticancer Drugs Associated With Increased Toxicity,"Many of the new anticancer agents improve effectiveness, but they also increase morbidity and mortality because of their toxicity."
  August 2012 ,Medscape Medical News,Diabetes: Another Late Complication of Radiotherapy ,"Among other late effects, cancer survivors who underwent abdominal or total body radiotherapy have an increased risk for diabetes."
  August 2012 ,Medscape Medical News,Statin Potency Linked With Muscle Weakness ,The highest rates of muscle-related adverse effects are associated with the strongest statin drugs.
  August 2012 ,Reuters Health Information,Fluoroquinolones Tied to Higher Risk of Serious Arrhythmias,"Fluoroquinolones, especially gatifloxacin, moxifloxacin and ciprofloxacin, are associated with significantly increased risks of serious arrhythmias, according to a new study."
  August 2012 ,News Alerts,FDA Warns of Codeine Overdose Risk After Pediatric Surgery,A small percentage of children convert appropriate doses of codeine into potentially lethal levels of morphine in their bloodstream.
  August 2012 ,Heartwire from Medscape,Statins Linked With Development of Cataracts,"Statin users are more than 50% likelier to develop age-related cataracts than nonusers, according to the results of a new study. And those with type 2 diabetes taking statins were at even greater risk, say the researchers. "
  August 2012 ,Medscape Medical News,Photosensitizing Antihypertensives Raise Lip Cancer Risk,"Patients initiating hydrochlorothiazide or another photosensitizing agent need a reminder to avoid sun exposure, researchers say. "
  July 2012 ,Medscape Medical News,Sirolimus Cuts Skin Cancer Risk in Transplant Patients,A switch to sirolimus appears to reduce the risk for new skin cancers in kidney transplant patients.
  July 2012 ,News Alerts,"Calcitonin Linked to Cancer Risk, EMA Warns","The European version of the FDA is recommending market withdrawal of calcitonin nasal spray, used to treat osteoporosis. Two brand-name versions are marketed in the United States."
  July 2012 ,Medscape Medical News,"FDA Puts 4 Drugs, X-Ray Contrast Agent on Watch List",An appearance on the list does not mean that the FDA has determined that the drug actually poses the reported health risk. 
  July 2012 ,News Alerts,Leucovorin Calcium Lots Subject to Voluntary Recall,Three lots of leucovorin calcium lots subject to recall due to evidence of particulate matter.
  July 2012 ,Medscape Medical News,Platinum-Induced Ototoxicity in Children a Continuing Issue,"New recommendations have been made related to otoprotection in children receiving platinum-based chemotherapy, including a new ototoxicity scale."
  July 2012 ,Medscape Medical News,Avoiding Severe Toxicity From 5-FU and Related Drugs,A multiparametric approach to screening identifies more patients who are likely to suffer toxic effects and who might even die from 5-fluorouracil (5-FU) and related chemotherapies.
  December 2012 ,News Alerts,32-Mg IV Zofran Pulled From Market,"This particular dose of the antinausea drug can lead to a deadly heart rhythm, says the FDA, which expects voluntary recalls of generic versions as well."
  November 2012 ,Medscape Medical News,Greater Monitoring of Clozapine for Serious AEs Needed,"Current guidelines require monitoring for agranulocytosis when using clozapine to treat schizophrenia, but new data strongly suggest additional monitoring for other adverse events is warranted."
  November 2012 ,WebMD Health News,Drugs That Interact With Grapefruit on the Rise,"The number of drugs that can be risky when taken with grapefruit is on the rise, largely due to the influx of new medications and chemical formulations, a new study shows."
  November 2012 ,Heartwire from Medscape,New WHI Analysis Links HRT to Atrial Fibrillation,Recent linkage of the WHI trials to the Medicare database has allowed researchers to accurately analyze the rate of AF among women taking HRT in the trial and compare it with those who were not taking hormones.
  November 2012 ,Medscape Medical News,History of Atopy May Predict Serious Adverse Drug Reactions,"People with a history of asthma, eczema, allergic rhinitis, or an adverse reaction to drugs are more likely to have a severe adverse drug reaction to a new medication."
  November 2012 ,Medscape Medical News,Excessive Acetaminophen Dosing Too Common in Hospitals,"Excessive amounts of acetaminophen were given to at least 4% of adult inpatients studied, according to a retrospective review of the electronic medical records of 14,000 patients."
  November 2012 ,WebMD Health News,Spine Infections Hit Fungal Meningitis Survivors,A dangerous second infection seen in survivors of tainted-shot outbreak.
  November 2012 ,News Alerts,FDA: Bleeding Risk With Dabigatran Similar to Warfarin,The US Food and Drug Administration has reported that the bleeding risk with dabigatran etexilate is comparable with that observed with warfarin. 
  November 2012 ,News Alerts,2nd Pharmacy Recalls Thousands of Drugs,"Ameridose, a Massachusetts compounding pharmacy closely linked to the NECC pharmacy at the heart of the fungal meningitis outbreak, today recalled thousands of drugs sold to hospitals across the U.S."
  October 2012 ,Reuters Health Information,U.S. Regulator Needs New Authority Over Compounding Pharmacies: Report,"The U.S. Food and Drug Administration's power to regulate compounded drugs similar to those linked to a deadly meningitis outbreak is legally nonbinding and lacks the authority of stringent standards imposed on drug manufacturers, according to a congressional report released on Sunday."
  October 2012 ,News Alerts,"Child Poisonings From Eye Drops, Nose Sprays","Over-the-counter eyedrops and nose sprays contain powerful drugs that are poisonous in surprisingly small amounts if swallowed, the FDA warns."
  October 2012 ,Medscape Medical News,Bisphosphonates and Esophageal Cancer: No Link Seen,A meta-analysis reveals no link between bisphosphonate use and esophageal cancer.
  October 2012 ,Medscape Medical News,Drospirenone Increases Venous and Arterial Blockage Risks ,A large retrospective study found that women using oral contraceptives containing drospirenone were at significantly increased risk for arterial thrombotic and venous thromboembolic events. 
  October 2012 ,Medscape Medical News,FDA Adds 8 Drugs to Watch List,Making the list does not mean that the FDA has concluded that the drug poses the reported health risk. 
  October 2012 ,Medscape Medical News,Staph Vaccine Linked to Multiorgan Failure and Death,"A trial of an experimental vaccine against Staphylococcus aureus to prevent bacteremia and wound infections after surgery has produced disappointing results, despite a robust immunologic response."
  October 2012 ,Medscape Medical News,Cognitive Training Helps 'Chemo Brain' in Cancer Survivors,Long-term breast cancer survivors stayed sharper with a computerized intervention designed to improve speed of processing.
  September 2012 ,Medscape Medical News,High Incidence of Kidney Stones With Atazanavir ,"Patients taking ritonavir-boosted atazanavir were 10 times more likely to develop kidney stones than patients taking other protease inhibitors, a new study shows."
  September 2012 ,Medscape Medical News,Study Stirs Controversy About Risks From Chemotherapy,"After 3 years of follow-up, there was no increased risk for blood cancers overall, but a prominent American oncologist has criticisms of the study."
  September 2012 ,News Alerts,FDA Warns of Potential Heart Failure Risk With Pramipexole,FDA has notified healthcare professional of their ongoing review of pramipexole for potential heart failure risk.
  September 2012 ,Medscape Medical News,Statins May Increase Pneumonia Risk ,"Statins might increase the risk for pneumonia, a new study suggests."
  March 2013 ,Medscape Medical News,Web Searches May Help Identify Unreported Drug Adverse Effects,"Analyzing search terms people type into their Web browsers may help spotlight previously unknown harmful drug adverse effects, according to a study that examined the search habits of 6 million users."
  March 2013 ,Medscape Medical News,Pruritus Risk High in Cancer Patients on Targeted Therapy,"Almost 20% of cancer patients receiving an epidermal growth-factor inhibitor or a mammalian target of rapamycin experience dermatologic adverse effects, 2 new studies show."
  February 2013 ,Medscape Medical News,Ocular Complications After HSCT in Children,"In children, eye complications commonly develop within 1 year of hematopoietic stem cell transplantation (HSCT), but they generally do not threaten vision."
  February 2013 ,Medscape Medical News,Risk for Acute Myeloid Leukemia Linked to Chemotherapy,The risk of developing treatment-related acute myeloid leukemia needs to be weighed against the benefits of chemotherapy
  February 2013 ,News Alerts,Codeine in Young Children Linked to Serious Adverse Events ,The FDA is warning again that several young children have developed serious adverse events after receiving codeine for pain relief after tonsillectomy. 
  February 2013 ,Medscape Medical News,Mortality Doubles With High Calcium Intake Plus Supplements,"However, a new study results suggest that supplements, rather than intake level, are the problem."
  February 2013 ,Medscape Medical News,Three Drugs Added to FDA Watch List,A drug's appearance on the list does not mean that the agency has concluded that the drug actually poses a health risk. The jury is still out.
  February 2013 ,Reuters Health Information,Cardiovascular Toxicity With Tx for Advanced Kidney Cancer,"Agents that target the mTOR axis, which have become particularly important in treating advanced renal cell carcinoma (RCC), have significant adverse cardiovascular effects."
  January 2013 ,News Alerts,France to Suspend Sale of Diane 35,"The French equivalent of the FDA said the acne drug, also used off-label as an oral contraceptive, raises the risk for deadly venous thromboembolism."
  January 2013 ,News Alerts,"Tolvaptan Poses Risk for Serious Liver Damage, FDA Warns","The drug, approved for hyponatremia, probably caused the liver damage experienced by 3 patients during kidney disease trials, according to the agency."
  January 2013 ,Reuters Health Information,Acute Anterior Uveitis After Intravenous Zoledronate,"About one in 100 patients could develop acute anterior uveitis (AAU) in the week after receiving intravenous zoledronate, researchers from New Zealand report."
  January 2013 ,Medscape Medical News,Diphtheria Vaccine Administered in the Thigh Appears Safer ,A new study of 1.4 million children shows less risk for local reaction among those given the diphtheria vaccine in the thigh rather than the arm.
  January 2013 ,News Alerts,Serious Skin Reactions Prompt EMA Review of Benzodiazepine,Concerns over serious skin reactions with medications containing a commonly used benzodiazepine have prompted a European Medicines Agency review.
  January 2013 ,News Alerts,FDA Recommends Lower Bedtime Dose for Zolpidem,"On the basis of new data showing morning blood levels sufficiently high to impair alertness in some patients with insomnia, the agency is recommending lower bedtime doses of zolpidem products."
  December 2012 ,News Alerts,FDA Warns Against Unapproved Drugs From Foreign Suppliers,The FDA has sent a letter to 350 medical practices in the United States over possible receipt of unapproved and possible unsafe medications from a foreign supplier.
  December 2012 ,News Alerts,Telaprevir Linked to Potentially Fatal Skin Reaction,Some patients have died when they continued to receive telaprevir combination treatment after the onset of a serious skin reaction.
  December 2012 ,Medscape Medical News,Safety Info for Generic Drugs Often Differs From Brand Label,Bioequivalent drugs often differ from brand name drugs in their safety labeling.
  December 2012 ,Medscape Medical News,Genotype Predicts Treatment-Related Mortality in AML,The presence of a specific genetic marker appears to be correlated with less treatment-related mortality in certain populations.
  December 2012 ,Medscape Medical News,"'Chemo Brain' May Actually Be Worry and Fatigue, Says Study",Cognitive problems can precede chemotherapy
  December 2012 ,Medscape Medical News,FDA Rejects NRDC Petition to Ban Lindane ,The lice and scabies treatment is no longer widely used.
  April 2013 ,Medscape Medical News,'One Size Fits All' Drug Dosing Gives Suboptimal Results,Many patients receive inappropriate drug doses and subsequently have poor results because drug serum levels are never tested.
  April 2013 ,News Alerts,FDA Issues Warning About Antiseizure Drug Potiga,The US Food and Drug Administration has issued a warning that the antiseizure drug Potiga can cause pigment changes and eye abnormalities.
  April 2013 ,Reuters Health Information,Steroids Tied to Local Reactions to Yellow Fever 17D Vaccine,"Patients receiving systemic corticosteroids seem to be at particular risk for local reactions to the yellow fever 17D vaccine, French researchers say."
  April 2013 ,News Alerts,Another Compounding Company Recalls All Sterile Product,"Balanced Solutions Compounding Pharmacy has voluntarily recalled all lots of its sterile drug products because of sterility concerns, the FDA says. "
  April 2013 ,News Alerts,FDA Announces Recall of ApotheCure and NuVision Products,US health regulators say sterile drug products from ApotheCure and lyophilized products from NuVision Pharmacy should not be administered to patients. 
  April 2013 ,News Alerts,Strontium Ranelate Restrictions Recommended in EU,An EU regulatory committee has recommended restricting the use of the osteoporosis drug strontium ranelate (Protelos/Osseor) to reduce the risk for adverse cardiac events in postmenopausal women.
  April 2013 ,News Alerts,Drugs From Shamrock Medical Solutions May Be Mislabeled ,"All drugs distributed by Shamrock including tablets, vials, ophthalmic and otic solutions and patches should be removed from inventory and not used, the FDA said today. "
  April 2013 ,News Alerts,Green Valley Drugs Announces Nationwide Recall,"Lack of ""sterility assurance"" prompts the company to recall all lots of all sterile products compounded, repackaged, and distributed by the pharmacy."
  April 2013 ,Medscape Medical News,Preventing Heart Damage From Chemotherapy: OVERCOME Trial,A pilot study shows that the combination of enalapril plus carvedilol prevented left ventricular damage in cancer patients undergoing intensive chemotherapy. 
  April 2013 ,Medscape Medical News,Adverse Drug Events Found by Mining Clinical Notes in EHR ,Unstructured clinical notes written in electronic health records can be used to identify drug adverse events and drug-drug interactions.
  April 2013 ,Medscape Medical News,Amiodarone Linked to Increased Cancer Risk in Men,The widely used antiarrhythmic drug appears to increase the risk for cancer in men in a dose-dependent manner.
  April 2013 ,Reuters Health Information,Safety Warnings for High-Risk Meds Missing From Smartphone Apps,Most electronic pharmacopoeia (EP) smartphone apps do not place important safety warnings for extended release or long acting (ER/LA) opioid formulations ahead of or on the same screen as prescribing information.
  April 2013 ,Medscape Medical News,'Call to Action' to Minimize Cataract Surgery Complications,"Surgical strategies and newer technology can protect children from major complications of cataract surgery, which can arise shortly after repair or decades later, so long-term monitoring is warranted."
  April 2013 ,Medscape Medical News,Mirabegron Showing Promise for Overactive Bladder,"The safety and adverse-effect profile of mirabegron compares favorably with that of tolterodine and placebo, new research shows."
  April 2013 ,Medscape Medical News,S aureus Vaccine for Heart Surgery Appears Harmful,A vaccine to prevent postoperative S aureus infection is associated with an overall lack of efficacy and a higher mortality rate in a randomized controlled trial.
  April 2013 ,Medscape Medical News,Drug for Depression Mutes Chemo Nerve Pain,A phase 3 study demonstrates that duloxetine can improve chemotherapy-induced peripheral neuropathy.
  March 2013 ,Medscape Medical News,Once-Daily Ribavirin Promising for Hepatitis C,"Once-daily ribavirin as part of triple therapy does not increase toxicity, and patients prefer it, a new study finds."
  March 2013 ,News Alerts,EMA Recommends Restricting Cilostazol Use   for PAD,The Europeans Medicines Agency has recommended   restricting the use of cilostazol in patients with   intermittent claudication. Use should be avoided in   those     with cardiac problems or on dual anticoagulants
  March 2013 ,News Alerts,More Adverse Events Reported for Surgical Waste System ,"The recalled Stryker devices, still in use by facilities lacking an alternative, can damage soft tissue, muscle, and vital organs when improperly used. The FDA has received reports of injuries and deaths. "
  March 2013 ,News Alerts,"Azithromycin Poses Fatal Cardiac Risk, FDA Warns",Clinicians should consider the risk for a prolonged QT interval and torsades de pointes in patients already at risk for adverse cardiovascular events.
  June 2013 ,News Alerts,FDA Warns of Increased Mortality Risk With HES Solution,"Do not use hydroxyethyl starch solution in critically ill patients because of the increased risk for death and renal injury, the agency said today."
  June 2013 ,Medscape Medical News,Entecavir May Prevent HBV Reactivation in Lymphoma Patients,Antiviral prophylaxis with entecavir might help prevent rituximab-associated hepatitis B virus (HBV) reactivation in patients with lymphoma and 'resolved' hepatitis B.
  June 2013 ,Medscape Medical News,AMA Urges Insurers to Cover Fertility Preservation,The AMA has ruled that fertility preservation for patients diagnosed with cancer should be covered by insurance -- just as reconstruction after mastectomy is.
  June 2013 ,Medscape Medical News,Drug Discontinuations Rampant in Rheumatoid Arthritis,"In the modern era of biologics, up to one third of patients with rheumatoid arthritis still discontinue therapy within a year, most often because of lack of efficacy."
  June 2013 ,News Alerts,European Committee Recommends Restricting Flupirtine,"Reports of liver problems, including sometimes fatal liver failure, prompt drug risk committee to recommend restricting use to those unable to take other analgesics and weekly liver function tests."
  June 2013 ,Medscape Medical News,Childhood Cancer Survivors May Have 'Premature Aging',"A new study reveals that by middle age, they have a high rate of health problems."
  June 2013 ,Reuters Health Information,Dual HER-2 Blockade Doesn't Boost Cardiac Toxicity,Dual HER2 blockade didn't increase heart problems in a meta-analysis of data from patients with HER2-positive breast cancer.
  May 2013 ,News Alerts,Almitrine Will Be Withdrawn as COPD Therapy in 3 EU Nations ,"Once a go-to treatment for chronic respiratory failure in France, Portugal, and Poland, almitrine no longer passes the benefit/risk test, say European drug regulators."
  May 2013 ,News Alerts,EMA Recommends That Trobalt Be Last Line in Partial Epilepsy,"The Committee for Medicinal Products for Human Use recommends restricting use of retigabine, aka ezogabine, in the United States, to last-line therapy because of the risk for retinal pigmentation."
  May 2013 ,Medscape Medical News,ASCO Issues Updated Guidelines on Fertility Preservation,The updated guidelines for fertility preservation in cancer patients reflect advances in the field and contain minor but important changes.
  May 2013 ,Medscape Medical News,Repeated EHR Alerts Desensitize Clinicians,"Repeated inappropriate alerts in electronic health records desensitize clinicians and may cause them to overlook true positive alerts, as shown in a newly published case report."
  May 2013 ,News Alerts,FDA Expands Alert to All Sterile NuVision Drug Products,The agency has recommended that health providers not use any sterile drug product made by Dallas-based compounding pharmacy NuVision because of concerns that the products may not be sterile. 
  May 2013 ,Medscape Medical News,Seniors at High Risk for Adverse Drug Events,"Therapeutic competition and adverse drug events jeopardize the health of older adults, 2 new studies show."
  May 2013 ,News Alerts,EU Regulators Recommend Withdrawing Almitrine,"The benefits of almitrine in managing COPD no longer outweigh the risks of marked weight gain and peripheral neuropathy, given alternative treatments, a committee of the European Medicines Agency said. "
  May 2013 ,News Alerts,FDA Label Changes for Zolpidem Products,A new safety communication from FDA recommends against next-day driving with extended-release zolpidem  and approves dosing changes previously stated because of known next-morning risks.
  May 2013 ,Medscape Medical News,Tearing Related to Docetaxel-Based Chemotherapy,"Tearing occurs in the majority of patients who receive adjuvant docetaxel-based chemotherapy regimens, but it is not caused by lacrimal duct obstruction."
  May 2013 ,News Alerts,FDA Warns Against Valproate to Prevent Migraine in Pregnancy,The FDA strengthened warnings against use of valproate products to prevent migraine in pregnant women.
  May 2013 ,News Alerts,"Latest FDA Watch List: 2 Drugs, All Acetaminophen Products",The FDA added acetaminophen products to the list after getting reports of severe skin reactions. The agency studies drugs on the list to determine if they actually cause the adverse events reported.
  May 2013 ,Medscape Medical News,Zolpidem Linked to Sharp Increase in ED Visits,SAMHSA reports that drug-related emergency department visits for adverse events connected to the sleep medication zolpidem jumped by almost 220% from 2005 to 2010.
  April 2013 ,News Alerts,FDA Limits Use of Samsca Due to Liver Injury Risk ,"The US Food and Drug Administration has announced new restrictions on the use of tolvaptan because of the potential risk for liver injury, including length of use."
  September 2013 ,News Alerts,PRAC Recommends Restrictions on SABAs in Obstetrics,"The committee says short-acting beta-agonists should no longer be used in oral or suppository forms in obstetric indications, citing cardiovascular risks."
  September 2013 ,Reuters Health Information,Pyridoxine Does Not Seem to Benefit Hand-Foot Syndrome,"Pyridoxine (vitamin B6) does not seem to benefit patients with hand-foot syndrome (HFS) caused by chemotherapy, a new meta-analysis suggests."
  August 2013 ,Medscape Medical News,Genetic Marker May Identify Risk for Statin-Induced Myopathy ,Genetically determined variation in expression of the glycine amidinotransferase gene may be associated with differences in susceptibility to statin-induced myopathy. 
  August 2013 ,Medscape Medical News,Hodgkin's Lymphoma Treatment and Risk for Stomach Cancer,"The treatment for Hodgkin's lymphoma appears to increase the risk for stomach cancer, especially in patients who received high doses of abdominal radiation."
  August 2013 ,Reuters Health Information,Skin Biopsies Not Useful for Diagnosing Drug-Induced Rash,"Skin biopsies are not useful in the differential diagnosis of drug-induced exanthems (DIE), a new retrospective study shows."
  August 2013 ,Reuters Health Information,VEGFR-TKI Related Hemorrhages Usually Mild in Cancer Patients,"In cancer patients, use of vascular endothelial growth factor receptor-tyrosine-kinase inhibitors (VEGFR-TKIs) is linked to more hemorrhagic events, but these generally aren't high grade."
  August 2013 ,News Alerts,FDA: Don't Use Any Sterile Product From NuVision Pharmacy,"Sterile products from NuVision may still pose serious risks to patients and should not be used, the FDA said. "
  August 2013 ,Heartwire from Medscape,Genotyping Might Cut Muscle-Pain Risk With Statins,"Mutations that affect serum levels of two statins likely account for huge serum-level variations among patients, suggesting they could help guide statin dosing to avoid the drugs' major side effects; researchers say it's probably a statin class effect."
  August 2013 ,News Alerts,More Injectable Benztropine Mesylate Recalled in US,"Nexus Pharmaceuticals has recalled more than 46,000 vials of benztropine mesylate because of the potential presence of particulate matter. "
  July 2013 ,Reuters Health Information,Strong Genetic Link to Carbamazepine Skin Reactions in Asians,"A new review shows a 'strong' link between the HLA-B*1502 allele and carbamazepine-induced Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in Han-Chinese, Thai and Malaysian populations."
  July 2013 ,Medscape Medical News,Birth Defects Linked to Mothers' Use of Cold Medicine,"However, the absolute number of cases was low, making true relationships hard to confirm and absolute risks small even with decongestant use, the authors warn."
  July 2013 ,Medscape Medical News,EU Agency Has No New Concerns on Incretin Diabetes Drugs ,"Current data do not confirm recent concerns over an increased risk for pancreatic adverse events with GLP-1-based type 2 diabetes drugs, says the European Medicines Agency."
  July 2013 ,News Alerts,Europe Recommends Restrictions for Metoclopramide,The Committee on Medicinal Products for Human Use has recommended restrictions on metoclopramide to minimize neurologic adverse effects.
  July 2013 ,Medscape Medical News,New Results for ESAs in Early Breast Cancer Reignite Debate,Results from a study of the use of an erythropoiesis-stimulating agent (ESA) to treat chemotherapy-induced anemia in patients with early-stage breast cancer have now been published.
  July 2013 ,Reuters Health Information,Merck Says FDA Needs More Time for Post-Surgery Drug Review,"Merck & Co Inc said on Tuesday that U.S. health regulators need more time to review its application to sell sugammadex, an injection designed to reverse the effects of muscle relaxants used during surgery. "
  July 2013 ,Heartwire from Medscape,"Beta-blockers in HF Get Bum Rap for Most 'Side Effects,' Says Study","Many adverse effects linked to beta-blockers in heart-failure trials, which made their way into the labeling, were shown in a new analysis to have been no     more common with the drugs than with placebo. The result is a disaster for some patients, according to researchers."
  July 2013 ,Medscape Medical News,Acute Renal Injury May Be Associated With mTOR Inhibitors,French researchers have observed a potentially new and serious adverse consequence in cancer patients treated with an mTOR inhibitor.
  June 2013 ,Medscape Medical News,"Vaccines Not Linked to Guillain-Barre, Asserts 13-Year Trial","A large retrospective analysis spanning 13 years found no association between vaccinations and development of Guillain-Barre syndrome; but not everyone agrees, and a few gnawing questions remain."
  June 2013 ,Medscape Medical News,Largest Steroid Injection Outbreak Kills 55 People,CDC researchers have established that immunohistochemistry analysis is highly sensitive in detecting fungus.
  June 2013 ,News Alerts,"FDA Adds Antinausea, Cardiac Drugs to Watch List",A drug's appearance on the FDA watch list does not mean the agency has determined that there is a causal link to reported health problems.
  November 2013 ,News Alerts,EU Strengthens Warning on Ponatinib,"Ponatinib will remain on the European market for now, but will have a stronger warning about the associated risk for cardiovascular toxicity."
  November 2013 ,Medscape Medical News,"Market Removal of Ponatinib Raises Questions, Concerns","The sales and marketing suspension of ponatinib raises questions about accelerated drug approvals, the monitoring of cardiovascular toxicity in cancer patients, and the evaluation of risks and benefits."
  November 2013 ,Medscape Medical News,Bariatric Surgery Safe in Severely Obese Teenagers ,"The Teen-LABS study provides some important early safety data and insights into the comorbidities of teenagers,  who undergo bariatric surgery. "
  October 2013 ,News Alerts,FDA Label Changes Underline Risks With Ezogabine,"FDA has announced approval of label changes for ezogabine (Potiga) to underline risks for retinal abnormalities, potential vision loss, and skin discoloration, including a new boxed warning."
  October 2013 ,Medscape Medical News,Sorafenib Side Effects Not Inconsequential in Thyroid Cancer,"The drug's side effects, particularly hand-foot skin reactions, stand out in a health-related quality of life assessment of the DECISION trial."
  October 2013 ,Medscape Medical News,"Physicians Mum About Overdiagnosis Risks, Patients Say","Clinicians may not tell most patients about the possibility of overdiagnosis and overtreatment as a result of cancer screenings, according to a patient survey. "
  October 2013 ,Medscape Medical News,Bariatric Surgery: BMI Disputed as Key Eligibility Criterion ,"Age and diabetes, not BMI, turn out to be major predictive factors for mortality in obese individuals and should be used as criteria for bariatric surgery eligibility."
  October 2013 ,Medscape Medical News,Chemo-Induced Menopause Symptoms Similar to Spontaneous,"Whether menopause is treatment-induced or spontaneous, the symptoms are alike, a new study has found."
  October 2013 ,Reuters Health Information,Nursing Intervention Improves Pelvic Radiation Bowel Symptoms,"Patients with radiotherapy-induced gastrointestinal symptoms who receive a targeted intervention do better than those given usual care, UK researchers say."
  October 2013 ,Reuters Health Information,Heart Failure With Trastuzumab in Women With Cardiac Comorbidity,"Breast cancer patients treated with trastuzumab are at high risk of congestive heart failure(CHF), particularly if they are older or have cardiac comorbidities, a new study shows."
  October 2013 ,Medscape Medical News,"Metoclopramide: No Link Seen With Birth Defects, Stillbirth ","A study of more than 40,000 women who used metoclopramide during pregnancy found no significant link between use of the drug and risks for congenital malformations or other adverse outcomes. "
  October 2013 ,Medscape Medical News,Debate Continues on Osteoporosis Treatment in CKD ,Whether to treat patients with chronic kidney disease with osteoporosis drugs to reduce fracture risk was the subject of a heated debate at the ASBMR meeting last week. 
  October 2013 ,Medscape Medical News,Pancreatic Atrophy: Adverse Effect of Long-term Sorafenib?,Two patients who had been taking sorafenib for 2.5 to 3 years were found on CT scans to have a 20% to 25% decrease in pancreas volume.
  September 2013 ,News Alerts,Tigecycline Mortality Risk: FDA Adds Boxed Warning,The FDA advises clinicians to use the intravenous antibiotic only 'in situations where alternative treatments are not suitable.' 
  September 2013 ,Medscape Medical News,Vancomycin Alternatives Don't Improve Kidney Outcomes,"Switching high-risk patients to an alternative to vancomycin does not change the nephrotoxicity, researchers warn."
  September 2013 ,Medscape Medical News,Microbiota Predict Chemotherapy-Induced Diarrhea,"For the first time, researchers have linked changes in gut microbiota and chemotherapy-induced diarrhea in patients with non-Hodgkin's lymphoma."
  September 2013 ,News Alerts,FDA Restricts Long-term Opioid Use to Combat Abuse,"The indication is no longer for 'moderate to severe pain,' but 'pain severe enough' to warrant 24/7 medication when other treatments fail."
  September 2013 ,Medscape Medical News,"Day-of-Week, Hospital Volume Differences in Delivery Outcome",Day of week and hospital volume affect asphyxia at birth and cesarean rates.
  September 2013 ,News Alerts,Serious Skin Reactions Reported With Sunitinib (Sutent),"Toxic epidermal necrolysis and Stevens-Johnson syndrome have been reported ""very rarely"" in patients taking sunitinib (Sutent). Two cases were fatal. "
  September 2013 ,News Alerts,PRAC Wants Numeta G13%E Off the Market,The committee wants marketing authorization of the intravenous nutrition preparation Numeta G13%E suspended because of a risk for hypermagnesemia in premature infants.
  January 2014 ,Medscape Medical News,Researchers Uncover Mechanisms of ICU Delirium,New discoveries about delirium and coma in patients in the intensive care unit (ICU) could lead to new treatments.
  January 2014 ,Medscape Medical News,5-Fluorouracil Effective Treatment for CIN 2 in Small Trial,Topical 5% 5-fluorouracil may be an effective treatment for cervical intraepithelial neoplasia 2 in women.
  January 2014 ,FDA Approvals,FDA Approves First Combination Therapy for Melanoma,Both drugs were previously approved for single-agent use in advanced melanoma.
  January 2014 ,News Alerts,Nipro Glucose Meters Recalled Due to Faulty Settings,Around 500 glucose meters from Nipro Diagnostics have been found to display glucose readings in mmol/L rather than the correct mg/dL used in the United     States. 
  January 2014 ,News Alerts,FDA Issues Safety Warning for Sodium Phosphate,The FDA has warned that using more than 1 dose in 24 hours of over-the-counter sodium phosphate drugs to treat constipation can cause 'serious harm.' 
  January 2014 ,Reuters Health Information,Repeat Radiation Helps Ease Pain of Bone Metastases,"Patients with painful bone metastases have a good chance of benefiting from a second round of palliative radiation, regardless of treatment schedule, according to a new randomized controlled trial."
  January 2014 ,Reuters Health Information,"Methotrexate Side Effects, Intolerance in Arthritis Patients","Rheumatoid arthritis and psoriatic arthritis patients commonly develop gastrointestinal side effects and intolerance to methotrexate therapy, researchers from the Netherlands report."
  December 2013 ,Medscape Medical News,Pharmacists Lead Attack On 'Hidden Epidemic' of Hypoglycemia,BJC HealthCare's interventions cut adverse events by 2100 and saved the hospital system $7 million.
  December 2013 ,Medscape Medical News,Taking Acid Inhibitors Long-term May Lead to B12 Deficiency,"Long-term proton pump inhibitor use is strongly associated with vitamin B12 deficiency, according to a Kaiser Permanente study."
  December 2013 ,Medscape Medical News,"Pediatric Drug Labeling Slow to Follow Law, Study Finds ","Most neonatal prescribing is still off-label, despite legislation."
  December 2013 ,Reuters Health Information,FDA Staff Cautious on Diabetes Drug Dapagliflozin,U.S. Food and Drug Administration staff said on Tuesday they were wary about the benefits versus the risks of AstraZeneca and Bristol-Myers Squibb's new diabetes drug dapagliflozin.
  December 2013 ,News Alerts,Capecitabine Linked to Potentially Fatal Skin Reactions,"According to the manufacturer, capecitabine has been linked to severe and potentially fatal skin reactions."
  November 2013 ,Reuters Health Information,Orexigen Diet Drug Does Not Increase Heart Risks,Orexigen Therapeutics Inc said study data showed its experimental obesity drug Contrave (bupropion/naltrexone) did not increase heart-related risks.
  November 2013 ,Medscape Medical News,Fluoroquinolones Not Linked to Retinal Detachment,"Any differences in absolute risk between patients receiving fluoroquinolone compared with control patients are likely to have limited, if any, clinical significance. "
  November 2013 ,Medscape Medical News,Advocates Lobby for Continued Access to Ponatinib in US,Cross-reactivity of allergens in pollens and foods can go haywire with ACE inhibitors.
  November 2013 ,Medscape Medical News,Allergies and ACE Inhibitors a Dangerous Combination,Critically ill patients are 10 times more likely to have indeterminate results.
  November 2013 ,Medscape Medical News,Penicillin Skin Test Not Recommended in Intensive Care,"The multicenter study joins the ranks of ONTARGET and ALTITUDE, 3 trials stopped early over safety concerns."
  November 2013 ,Medscape Medical News,NEPHRON-D Ends Combination Therapy for Diabetic Nephropathy,"In clinical practice, the risk for venous thromboembolism (VTE) 3 months after the start of chemotherapy is about double that seen in clinical trials."
  November 2013 ,Medscape Medical News,VTEs With Chemo 'Much Higher' in Real World Than in Trials,"Emergency department visits among infants resulting from cough and cold medicines have declined since product  withdrawals and relabeling, according to a new CDC study."
  January 2014 ,Medscape Medical News,Psychotropics Widely Prescribed for Intellectually Disabled,"The number of antipsychotic prescriptions for the intellectually disabled and those with mental health disorders does not differ much, but the overall number for both groups is still substantial."
  January 2014 ,Medscape Medical News,Culinary Culprits: Foods That May Harm the Brain,"A growing body of research suggests there is a strong link between mood and food, with inflammation and even gut microbiota seen as mechanistic factors."
  January 2014 ,Medscape Medical News,Peanut Allergy Effectively Countered With Oral Immunotherapy ,A phase 2 trial evaluating the use of oral immunotherapy for childhood peanut allergy has found that the approach benefited as many as 91% of children.
  January 2014 ,Medscape Medical News,Quality of Life Declines With Androgen Deprivation Therapy,"Effects seem to resolve within 24 months, investigators say."
  January 2014 ,Medscape Medical News,Sublingual Ragwitek Backed FDA Panel for Ragweed Allergy,"FDA panel recommends Ragwitek as sublingual immunotherapy for ragweed allergy, but with reservations about age of coverage."
  January 2014 ,Medscape Medical News,Enzalutamide Before Chemo Slows Metastatic Prostate Cancer,There is now updated data on use of the androgen receptor blocker in men with metastatic disease who have progressed on androgen deprivation therapy but are chemotherapy-naive.
  January 2014 ,Medscape Medical News,Hypomania: Can Antidepressants Be Reintroduced?,Antidepressant-associated hypomania did not recur during a 3-year follow-up after antidepressant treatment resumed without a mood stabilizer.
  January 2014 ,Heartwire from Medscape,Evolocumab Lowers LDL in Statin-Intolerant Patients,"Evolocumab, an investigational PCSK9 inhibitor, successfully lowered LDL-cholesterol levels from baseline to week 12 in patients unable to tolerate statins     because of side effects."
  January 2014 ,Medscape Medical News,Smoking Causes Diabetes; Doctors Should Help Patients Quit,"The new US Surgeon General's report cites, for the first time, evidence for a direct causal link between smoking and diabetes, further highlighting the     importance of clinical cessation efforts. "
  January 2014 ,Reuters Health Information,Neuromyelitis Optica: What Immunosuppressive Agent Is Best?,"Rituximab and mycophenolate are superior to azathioprine for treatment of neuromyelitis optica (NMO), a comparative analysis shows."
  January 2014 ,Medscape Medical News,The Good News on Antiamyloid Alzheimer's Therapies,"The trials of bapineuzumab and solanezumab in Alzheimer's were disappointing, but the studies, published now in New England Journal of Medicine, provide direction for the next round of research."
  January 2014 ,Medscape Medical News,"In-Hospital Adverse Events Decline, But Not Across the Board","Adverse event rates decline for acute myocardial infarction and congestive heart failure, but not for pneumonia or surgeries."
  January 2014 ,Medscape Medical News,Top 5 Pain Interventions to Avoid,First-line use of opioids for chronic noncancer pain is among the American Society of Anesthesiologists 'Choosing Wisely' list of questionable pain relief strategies.
  January 2014 ,Medscape Medical News,Synthetic Marijuana 'Spice' Linked to Stroke,"Recreational use of the synthetic marijuana compound 'spice' may be linked to ischemic strokes in young, otherwise healthy individuals."
  January 2014 ,Reuters Health Information,Nasal Packing Not Linked With Cardiopulmonary Complications,"Nasal packing to lower the risk of post-op bleeding and adhesions after septoplasty doesn't appear to cause cardiopulmonary complications, according to a new meta-analysis."
  January 2014 ,Medscape Medical News,Chinese Herbs Reduce Progression to Diabetes by a Third,"Tianqi, a capsule combination of 10 Chinese medicinal herbs, reduced progression from impaired glucose tolerance to type 2 diabetes by 32% over 12 months."
  January 2014 ,Medscape Medical News,Alemtuzumab Investigators Protest FDA Decision  ,"Several multiple sclerosis experts involved in clinical development of alemtuzumab (Lemtrada, Genzyme) have voiced disappointment and frustration over the recent FDA decision not to approve the drug. "
  January 2014 ,Medscape Medical News,'Suicide Test' May Aid Antidepressant Decision Making,A US company is developing a genetic test aimed at helping doctors identify patients at increased risk for suicide when antidepressant medications are prescribed.
  January 2014 ,Medscape Medical News,New Parkinson's Gene Therapy Shows Promise ,"A new approach to gene therapy for Parkinson's disease has shown promising results in a phase 1/2 study, with no major safety issues and some improvement in motor symptoms in all 15 patients treated.   "
  January 2014 ,Medscape Medical News,Off-Label Use of Drugs Found Safe in ICU,"Using prescription drugs for purposes outside of their intended indication is not a cause for concern in the intensive care unit (ICU), say researchers."
  February 2014 ,Medscape Medical News,FDA Panels: Primatene HFA Inhaler Not Recommended for Asthma,Panel members took some issue with over-the-counter availability as a replacement for appropriate medical care.
  February 2014 ,Medscape Medical News,BP Meds Linked to Serious Fall Injuries in Elderly,Researchers call for consideration of harms vs benefits for individual patients.
  February 2014 ,Heartwire from Medscape,Vegetarian Diet Cuts Blood Pressure in Meta-Analysis,"An analysis found consistent blood-pressure reductions, both in clinical trials and observational studies, that were roughly half of what     can be seen with drugs, but with ""desirable"" side effects."
  February 2014 ,Reuters Health Information,Pregnancy Not the Best Time to Lose Weight: Study,"Overweight and obese women who gain too few pounds, or even lose weight, during pregnancy may be putting their unborn child at risk, a new study suggests."
  February 2014 ,Reuters Health Information,High-Dose Vitamin D Supplements May Benefit People With Chronic Urticaria,"People plagued by chronic urticaria (hives) may benefit from high-dose daily vitamin D supplements, new research suggests."
  February 2014 ,International Approvals,Vokanamet Recommended by EMA for Type 2 Diabetes,"The Committee for Medicinal Products for Human Use of the European Medicines Agency recommended canagliflozin/metformin (Vokanamet, Janssen-Cilag International NV) for type 2 diabetes."
  February 2014 ,International Approvals,CHMP Backs Elosulfase Alfa for Rare Morquio A Syndrome,"Elosulfase alfa (Vimizim), approved earlier this month in the United States, replaces a missing enzyme that plays a key role in the rare, autosomal recessive lysosomal storage disease. "
  February 2014 ,Medscape Medical News,Dramatic Results With CARs in B-Cell Leukemia ,Results from 16 patients with B-cell acute lymphoblastic leukemia show a complete remission rate of 88% after infusions of modified T-cells.
  February 2014 ,Medscape Medical News,Radiation-Free Imaging Technique Breaks New Ground,A radiation-free alternative for staging malignant tumors in children and adolescents enhances MRI images with the iron supplement ferumoxytol.
  February 2014 ,Medscape Medical News,Citalopram Reduces Agitation in Patients With Alzheimer's ,"Results of the CitAD trial show 30 mg daily moderates agitation in AD but also affects cognition, can cause electrocardiography changes, and is no longer recommended in older adults."
  February 2014 ,Medscape Medical News,Mom's Voice Helps Preemies Improve Feeding Skills,"Premature infants  improved their oral feeding skills when given a pacifier-activated music device with their mother's voice, a randomized trial found."
  February 2014 ,FDA Approvals,FDA Clears the First Drug for Rare Morquio A Syndrome,Elosulfase alfa (Vimizim) treats Morquio A syndrome by correcting a deficiency in an enzyme important for metabolism. 
  February 2014 ,FDA Approvals,Ibrutinib (Imbruvica) Approved for CLL in US,The first-in-class inhibitor of Bruton's tyrosine kinase has been described as a 'turning point' in the treatment of chronic lymphocytic leukemia (CLL). 
  February 2014 ,Reuters Health Information,Fixed-Dose Rituximab Provides Durable Remission of Pemphigus,"Fixed-dose rituximab therapy can produce durable remission of pemphigus, a retrospective study suggests."
  February 2014 ,News Alerts,FDA Reviewing Saxagliptin Trial Data for Possible HF Risk,The FDA issued a communication this morning stating it has requested the trial data from the manufacturer so that it can investigate a possible association     between the use of saxagliptin and heart-failure risk.
  February 2014 ,Medscape Medical News,Heavy Psychotropic Med Burden Common in Bipolar Patients,"Many patients with bipolar disorder are being medicated with 4 or more drugs, including drugs for other psychiatric conditions."
  February 2014 ,Medscape Medical News,European Approval for Tecfidera as First-Line in MS ,European regulators have approved dimethyl fumarate as first-line therapy in multiple sclerosis. 
  January 2014 ,Medscape Medical News,Long-term Data Show Ra-223 Safe in Advanced Prostate Cancer,"Radium-223 prolonged survival in castration-resistant prostate cancer, and safety data at 1.5 years show it to have minimal toxicity."
  January 2014 ,Medscape Medical News,"Resistance, Aerobic Training May Reduce Pain in Fibromyalgia","Patients with fibromyalgia gained function, strength, and reduced pain and tenderness with resistance training. Aerobic training also reduced pain."
  January 2014 ,Medscape Medical News,Teriflunomide Approved in UK for MS; TOWER Published,"The drug is the first oral agent for first-line use in patients with relapsing-remitting MS in the UK, and it may become a popular option for patients with mild disease. "
  March 2014 ,Medscape Medical News,SBRT Cheaper but More Toxic Than IMRT for Prostate Cancer,"Stereotactic body radiotherapy (SBRT) is cheaper but more toxic than intensity-modulated radiotherapy (IMRT) for prostate cancer, according to a comparative study."
  March 2014 ,Medscape Medical News,"Insulin-Related Hypoglycemia: Common, Costly, Preventable","Insulin-related hypoglycemia leads to thousands of visits to emergency each year, especially among elderly patients, a new report shows. This is far too     common to be acceptable, says one expert."
  March 2014 ,Medscape Medical News,No Difference by Injection Approach for Low Back Pain,"Despite widespread belief of improved pain relief with transforaminal injections, randomized trials show no significant differences for relief of radiating low back pain or for function."
  March 2014 ,Medscape Medical News,TMS Relieves Symptoms in Teens With Resistant Depression,"Repetitive transcranial magnetic stimulation may be a useful therapy in teens with treatment-resistant depression, preliminary research suggests."
  March 2014 ,Medscape Medical News,"Sherwin Nuland, MD, Clear-eyed Witness to Death, Dies at 83",The surgeon and author of 'How We Die' urged clinicians to level with dying patients about what they are facing and to know when to give up on life-prolonging treatment.
  March 2014 ,News Alerts,PRAC Wants Restrictions on Domperidone Due to Cardiac Risks,"Reducing the recommended dose and duration of treatment with domperidone-containing antiemetics is key to minimizing its risks, the Committee said."
  March 2014 ,News Alerts,"EMA Panel Says Diacerein Should Stay, but With Restrictions","After reexamining diacerein-containing medicines, an EU panel has recommended that these products remain available, although with restrictions to manage risks."
  March 2014 ,Medscape Medical News,Vision Loss Reported After Cosmetic Facial Injections,"Dermal filler injections in the forehead led to vision loss, a rare but devastating event, in 3 patients."
  March 2014 ,FDA Approvals,"FDA Approves Aveed Testosterone Jab, with Restrictions","The FDA has approved Aveed, a long-acting depot form of testosterone, after 3 previous rejections, stipulating a boxed warning in the label and stringent     prescribing requirements."
  March 2014 ,News Alerts,Nationwide Recall of Antidepressant Issued,A nationwide recall of 3 different lots of the antidepressant Effexor has been issued by the drug's manufacturer due to possible contamination with a heart drug that could have fatal consequences.
  March 2014 ,Medscape Medical News,Oral Immunotherapy Reduces Sensitivity to Dust Mites,"An experimental sublingual tablet cut nasal symptoms by half and conjunctivitis by two thirds in early investigation, say researchers."
  March 2014 ,Medscape Medical News,No Benefit to Earlier Use of Bone Drug in Prostate Cancer,"Use of zoledronic acid for castration-sensitive prostate cancer does not decrease the risk for skeletal events, compared with treatment started after progression to castration-resistant disease."
  March 2014 ,Medscape Medical News,Memantine Discontinuation Rates Underestimated in Research?,Randomized clinical trials may underestimate the rate of memantine discontinuation and dose reductions in dementia patients.
  March 2014 ,Reuters Health Information,"Italian Watchdog Says Novartis, Roche Colluded Over Eye Drug","Italy's antitrust authorities said Novartis and Roche colluded to try to stop cancer drug Avastin (bevacizumab) from being used to treat a serious eye disease, and fined the Swiss drugmakers 182.5 million euros ($251 million)."
  March 2014 ,Medscape Medical News,Excellent Outcomes With Proton Therapy in Prostate Cancer,A new study shows extremely high efficacy in 5-year outcomes for prostate cancer patients in all risk categories.
  March 2014 ,Medscape Medical News,"Hypoglycemia Begets More Hypoglycemia, New ASPIRE Data Find","New analysis of the ASPIRE study of an insulin-delivery system's ""threshold-suspend"" function finds that the ability to ameliorate hypoglycemia is impaired     by prior hypoglycemia."
  March 2014 ,Medscape Medical News,New Interferon-Free Drugs for Hep C Show High Cure Rates,"Interferon has been the primary treatment for chronic hepatitis C for 2 decades, but new drugs promise better results with fewer adverse effects."
  March 2014 ,Medscape Medical News,Provaccine Messages May Backfire Among Parents,Researchers have found that current public health messages may be reducing the misperception about vaccines and autism but not increasing intent to vaccinate future children.
  March 2014 ,Heartwire from Medscape,Single-Patient Studies Test Statin-Related Myalgia,"When exposing eight patients to several double-blind statin and placebo challenges, none had a statistically significant difference in myalgia or other     pain measures on the statin compared with placebo."
  February 2014 ,Medscape Medical News,Improving QOL in Head and Neck Cancer as Survival Improves,Reducing radiation doses to organs not affected by cancer is becoming increasingly important as these patients are diagnosed at a younger age.
  March 2014 ,Medscape Medical News,All That Glitters Is Not Gold: AleCardio Dissected at ACC,Presentation of the AleCardio trial results at ACC provides a few more clues as to why the dual PPAR agonist aleglitazar has become the latest in a line of     these agents to fail spectacularly.
  March 2014 ,Medscape Medical News,Nintedanib: New Oral Angiogenesis Inhibitor in Lung Cancer    ,"When added to docetaxel in second-line therapy, the new agent improved survival in a subgroup of patients with adenocarcinoma histology."
  March 2014 ,Medscape Medical News,"ECT: Electrode Placement, Age Influence Depression Outcomes","In individuals with severe depression who are treated with ECT, electrode placement and patient age may have a significant influence on treatment outcomes."
  March 2014 ,Medscape Medical News,Culture Change Needed to Combat ICU Delirium,"A new study underscores the role of sedatives in delirium in the ICU, but surprisingly, no link was seen between sleep quality and delirium risk."
  March 2014 ,Medscape Medical News,"Unlike FDA, Europe Does Not Like Melanoma Combo Yet","The combination of trametinib and dabrafenib was approved by the FDA in January, but a European regulatory committee feels differently."
  March 2014 ,Medscape Medical News,New Agent Offers Promise for ALK-Positive NSCLC,"Ceritinib, a new targeted therapy, has demonstrated effectiveness in this patient subgroup, even in those who have progressed on crizotinib."
  March 2014 ,Reuters Health Information,Sanofi Faces Make-or-Break Verdict on Big Dengue Vaccine Bet, Sanofi expects final clinical results for its vaccine against dengue by late September and has already gambled on starting production despite some disappointing early trials data.
  March 2014 ,Medscape Medical News,ASCO Updates Node Dissection Early Breast Cancer Guideline,"Many women with early-stage breast cancer can avoid the more invasive axillary lymph node dissection, and instead have sentinel node biopsy, which has fewer complications."
  March 2014 ,Medscape Medical News,"New AAN Guideline on Cannabis, Alternative Medicine in MS",The guideline gives some support to cannabis products but emphasizes there is little evidence for most complementary and alternative medicine in multiple sclerosis.
  March 2014 ,Reuters Health Information,Poor Long-Term Survival After ICU Acute Kidney Injury,"Long-term survival remains poor after acute kidney injury (AKI) in the intensive care unit, but most of those who do survive don't need maintenance dialysis."
  March 2014 ,Reuters Health Information,Vismodegib Shrinks Keratocystic Odontogenic Tumors,"The oral Hedgehog pathway inhibitor vismodegib shrinks keratocystic odontogenic tumors (KCOTs) in patients with basal cell nevus syndrome (BCNS), according to results from a small clinical trial."
  March 2014 ,Medscape Medical News,SSRI May Negatively Affect Male Fertility,"The SSRI sertraline may have a negative impact on some semen parameters, a finding that may have implications for male fertility."
  March 2014 ,FDA Approvals,FDA Clears IV Formulation of Antifungal Posaconazole ,"Posaconazole (Noxafil) is now available in delayed-release tablets, oral suspension, and intravenous formulations. "
  March 2014 ,Medscape Medical News,Something in the Air? Ambient Lead Linked to Alzheimer's,Even exposure to very low levels of ambient lead may increase the risk for Alzheimer's disease in patients with amnestic mild cognitive impairment.
  March 2014 ,FDA Approvals,FDA OKs Propranolol Hydrochloride for Infantile Hemangioma,Hemangeol is the first and only pediatric oral formulation of propranolol hydrochloride for treatment of proliferating infantile hemangioma requiring systemic therapy.
  March 2014 ,Medscape Medical News,"After Metformin, Are Newer Drugs Better for Type 2 Diabetes?","A new analysis based on claims data suggests that sulfonylureas perform just as well as newer agents for second-line treatment of type 2 diabetes, but at     far lower cost."
  March 2014 ,Medscape Medical News,Penicillin 'Allergy' History May Be Inaccurate and Costly ,"Penicillin 'allergy' history is often inaccurate but is linked to longer hospital stay, significantly more antibiotic use, and increased C difficile, MRSA, and VRE prevalence. "
  March 2014 ,Medscape Medical News,Viral Hepatitis Meeting a Must for Healthcare Providers,The conference to be held at Mount Sinai in New York City will offer not-to-be missed talks on recent developments in hepatitis C treatment.
  March 2014 ,Heartwire from Medscape,Obesity's Genetic Trick Might Protect Against Its Ills,"Rising body-mass index seems to influence the switching mechanism of a gene with downstream physiologic effects, in one of the most extensive epigenetic     studies of obesity to date."
  March 2014 ,Heartwire from Medscape,The 'Real' Side-Effect Cost of Statins: Sorting Fact from Fiction,"In primary prevention, the risk of developing diabetes with statins is real, but just one in five cases of new-onset diabetes are caused by the drugs. In     secondary prevention, the risk is offset by the reduction in cardiovascular deaths."
  April 2014 ,Medscape Medical News,ASCO Launches New Survivorship Guidelines,ASCO has launched the first 3 guidelines as part of a series that will cover all aspects of cancer survivorship.
  April 2014 ,Medscape Medical News,Serious Side Effect Seen in MS Patients on Interferon Beta,"Unexpected cases of thrombotic microangiopathy have emerged in patients with MS taking a relatively new formulation of interferon beta in one report, but cases have been reported with all brands."
  April 2014 ,Medscape Medical News,Novel Nonopioid Approach Promising for Opioid Dependence,"The combination of a muscle relaxant, an antihistamine, and an anticonvulsant may be a better way to detox opioid-dependent patients than a protocol that involves buprenorphine/naltrexone."
  April 2014 ,FDA Approvals,FDA OKs Sublingual Grastek for Timothy Grass Pollen Allergy,"The FDA approved a grass pollen allergen extract for the treatment of Timothy grass pollen-induced allergic rhinitis, with or without conjunctivitis, in individuals aged 5 to 65 years."
  April 2014 ,Medscape Medical News,Lung Cancer: A Dose-Dependent Risk After Breast Cancer RT,"The risk of developing a primary lung cancer after radiotherapy for breast cancer increases in a dose-response manner, with these odds jumping 17-fold in smokers."
  April 2014 ,Medscape Medical News,Ocular Effects Common After Childhood Bone Marrow Transplant,"Children who undergo bone marrow transplantation can suffer ocular complications, such as cataract and dry eye syndrome, which can be long lasting and require treatment into adulthood."
  April 2014 ,Heartwire from Medscape,Calcium/CVD Risk Debate Gets New Fodder From Analysis,The meta-analysis contradicts previous studies suggesting that calcium supplements could increase the risk of MI.
  April 2014 ,Medscape Medical News,Mechanism for Ipilimumab Pituitary Toxicity Identified,"Expression of CTLA-4 on pituitary endocrine cells could underlie hypophysitis secondary to CTLA-4 blockade with ipilimumab, which has implications for care. "
  April 2014 ,Medscape Medical News,ED Drugs Linked to Increased Melanoma Risk,Data from the Health Professionals' Follow-up Study show a strong association between sildenafil use and melanoma risk.
  April 2014 ,Medscape Medical News,"VEGF Inhibitors Safe for AMD, Despite Expectations","In patients with age-related macular degeneration (AMD), cardiovascular risks might be more strongly associated with age than with vascular endothelial growth-factor (VEGF) inhibitors."
  April 2014 ,Medscape Medical News,Transcranial Stimulation in Disorders of Consciousness,"A short session of transcranial direct-current stimulation over the left dorsolateral prefrontal cortex may result in clinical improvement for patients in a minimally conscious state, early findings show."
  April 2014 ,Medscape Medical News,NIMH Tightens Up Funding Criteria for Clinical Trials,"In an effort to improve the development of treatments for psychiatric disorders, the NIMH has changed its funding policies for future clinical trials, including timelier reporting of results."
  April 2014 ,Medscape Medical News,First-in-Class Defibrotide for VOD Launched in Europe,"Defibrotide, a drug used to treat severe veno-occlusive disease (VOD), a life-threatening complication related to hematopoietic stem cell transplantation, has been launched in Europe."
  April 2014 ,Medscape Medical News,ASCO's New Strategy to Define 'Value' in Cancer Care,"Under the leadership of the Value in Cancer Care Task Force, ASCO has launched a strategic initiative to define value in cancer care."
  April 2014 ,Medscape Medical News,Pharmacists Well Placed to Educate About Dietary Supplements,"Pharmacists can educate people about widely used dietary supplements that could be harmful, especially when used in the presence of certain chronic health conditions."
  April 2014 ,Heartwire from Medscape,Darapladib Fails to Reduce CVD Risk in STABILITY,"pproximately one in five patients treated with darapladib stopped taking the investigational Lp-PLA2 inhibitor because of adverse effects, including     malodorous feces, urine, and skin."
  April 2014 ,Medscape Medical News,Hepatitis C Drug Trials to Take Spotlight at Liver Congress,The European Association for the Study of the Liver International Liver Congress 2014 will feature phase 3 data on all-oral regimens for hepatitis C.
  April 2014 ,Medscape Medical News,"Methotrexate Decreases Pain, Improves Function in Knee OA","Methotrexate, which is widely used for rheumatoid arthritis, also reduced pain and improved function in patients with knee osteoarthritis in a randomized controlled trial. "
  March 2014 ,Reuters Health Information,Gilead Has Discounted HCV Drug for Some Health Plans,"Gilead Sciences Inc, under fire for pricing a new hepatitis C drug at $1,000 a pill, has discount agreements with a number of health insurers, a company executive said in an interview."
  March 2014 ,Medscape Medical News,Heart-Failure Data for Alogliptin Prompt More Debate at ACC,"The possible risk of heart failure associated with the use of the dipeptidyl peptidase-4 inhibitor drugs for type 2 diabetes is once again in the     spotlight, with new data from the ACC meeting."
  May 2014 ,Medscape Medical News,TMS Cost-effective for Resistant Depression,"An economic analysis suggests transcranial magnetic stimulation is ""good value for money"" in patients with antidepressant-resistant major depression."
  May 2014 ,Medscape Medical News,NSAID Monotherapy Prevents Postsurgery Cystoid Macular Edema,"Bromfenac monotherapy prevented cystoid macular edema after cataract surgery better than a steroid plus an NSAID, in a 5-year analysis."
  May 2014 ,Medscape Medical News,Online Sex Supplements Linked to Serious Psychoactive Effects,"Ingredients found in sexual enhancement products sold online, such as yohimbine and horny goat weed, have been linked to several psychoactive effects, including anxiety, panic, and hallucinations."
  May 2014 ,Medscape Medical News,Nonstimulant May Provide Rapid Relief for Adult ADHD,An extended-release formulation of the nonstimulant metadoxine improves attention after a single dose in adults with predominantly inattentive ADHD.
  May 2014 ,Medscape Medical News,TMS Promising for Generalized Anxiety,"Repetitive transcranial magnetic stimulation appears to be a promising treatment for patients with generalized anxiety disorder, a frequently chronic condition characterized by debilitating worry."
  May 2014 ,Medscape Medical News,FDA Panel Rejects OTC Use of Montelukast (Singulair Allergy),The FDA advisory committee has recommended against use of partial expansion of montelukast for OTC use against allergic rhinitis.
  May 2014 ,News Alerts,"Ranbaxy Recalls Nearly 30,000 Packs of Allergy-Relief Drug in US","Indian drugmaker Ranbaxy Laboratories started recalling 29,790 packs of an allergy-relief medicine in the US in February after finding defects in the packaging."
  April 2014 ,Reuters Health Information,Glucantime Side Effects in Leishmaniasis Not Worse in Children,"Cutaneous leishmaniasis treatment with systemic meglumine antimoniate (Glucantime, Sanofi Aventis) is generally fairly well tolerated in children and the rate of adverse events is similar to that seen in adults."
  May 2014 ,Medscape Medical News,Pixantrone a 'Milestone' for Aggressive Relapsed B-cell NHL,Patients with aggressive B-cell non-Hodgkin's lymphoma (NHL) who have failed after second-line therapy have few options: now pixantrone can be used in Europe. 
  April 2014 ,Medscape Medical News,'Low-Risk' Kidney Stone Removal May Be Risky and Costly,"After low-risk procedures to remove urinary stones, patients often need an unplanned emergency visit at substantial cost, suggesting a need for interventions to identify and reduce complications. "
  April 2014 ,Reuters Health Information,Benefits of Delayed Umbilical Cord Clamping Gone by 12 Months,"Early benefits of delayed umbilical cord clamping (DCC) on iron stores seem to have disappeared by the time infants are one year old, researchers from Sweden report."
  April 2014 ,Medscape Medical News,AWARD-5: Dulaglutide Betters Sitagliptin in Type 2 Diabetes,"In patients with type 2 diabetes uncontrolled with metformin, adding weekly injections of dulaglutide led to better glycemic control at 1 year compared     with adding oral sitagliptin, with acceptable safety."
  April 2014 ,News Alerts,Domperidone Restrictions Endorsed in EU Due to Cardiac Risk,An EMA committee has confirmed recommendations to restrict the use of domperidone-containing antiemetics because of concerns about adverse cardiac effects. 
  April 2014 ,Medscape Medical News,Novel Agents for Migraine Prevention Look Good in Phase 2,Two new agents representing a novel mechanism of action for the prevention of migraine are generating much interest after showing promising results in phase 2 studies.
  April 2014 ,Medscape Medical News,FDA Considers Ban on 'Noxious' Devices for Behavior Control,The FDA is considering a complete ban on aversive electrical stimulation devices to control unwanted behaviors.
  April 2014 ,Medscape Medical News,"Gastric Bypass: Appetite Drop, Food Aversion Common Afterward"," Moreover, patients who lose their taste for certain foods--typically meat--are more likely to attain greater weight loss, researchers report."
  April 2014 ,News Alerts,Spinal Corticosteroids Run Risk of Severe Neuro Effects,"The FDA has announced that injections given to treat neck and back pain and radiating pain in the arms and legs may result, on rare occasions, in blindness, stroke, paralysis, and death. "
  April 2014 ,Medscape Medical News,Effects of Childhood Bullying Persist Well Into Adulthood,"Adults who were frequently bullied in childhood continue to be at risk for poorer mental, physical, and social health 4 decades later."
  April 2014 ,Reuters Health Information,Exemestane Well-Tolerated for Breast Cancer Prevention,"When given to prevent breast cancer in postmenopausal women, the aromatase inhibitor exemestane has little effect on quality of life, according to follow-up results of the MAP.3 trial."
  April 2014 ,Medscape Medical News,"In Prostate Hyperplasia, Combo Pill Slows Progress","Men with moderate symptoms of benign prostate hyperplasia treated with dutasteride plus tamsulosin hydrochloride fared better than those monitored with watchful waiting, new research shows."
  May 2014 ,Medscape Medical News,Psyllium as Effective as Loperamide for Fecal Incontinence,"Episodes of fecal incontinence can be nearly halved with either psyllium fiber or loperamide, a crossover placebo-controlled trial has shown."
  May 2014 ,Heartwire from Medscape,Specialized Clinic Gets Results in Resistant Hypertension,"The clinic, which includes a dietician, nurse practitioners, and physicians, including cardiologists and nephrologists, saw patients reduce their systolic     BP from 153 mm Hg to 130 mm Hg."
  May 2014 ,Medscape Medical News,Drug Reactions More Likely in Kids With Complex Conditions,Children with complex chronic conditions were 4 times as likely to visit the emergency department for an adverse drug event as other children.
  May 2014 ,Medscape Medical News,High Dropout Rate in Active Surveillance for Prostate Cancer,A real-world study of men with prostate cancer indicates that more than one third of men who undergo active surveillance drop out.
  May 2014 ,Reuters Health Information,Pre-praziquantel Snack Beneficial in Childhood Schistosomiasis,"Giving a snack prior to praziquantel treatment improved compliance and reduced the burden of schistosomiasis among children in Uganda, according to a new study."
  May 2014 ,Heartwire from Medscape,BMJ Withdraws Statement on Statin-Related AEs,"Two research papers erroneously cited that 20% of patients develop statin-related adverse events, a figure that is based on observational data. These     statements have been withdrawn and BMJ will review next steps."
  May 2014 ,Medscape Medical News,"Don't Treat Early-Stage Prostate Cancer in Older, Sicker Men","Older men diagnosed with early-stage prostate cancer who have pre-existing medical conditions, such as diabetes, COPD, and heart disease, derive no survival benefit from aggressive treatment."
  May 2014 ,Medscape Medical News,Appears Safe to Delay ADT When Prostate Cancer Recurs,Delaying androgen-deprivation therapy in men who have biochemical recurrence of prostate cancer did not affect survival in a new study.
  May 2014 ,Medscape Medical News,"New Glatiramer Dosing Convenient, Possibly Safer, in MS","Patients with relapsing-remitting multiple sclerosis who inject glatiramer acetate 3 times a week instead of daily experience fewer injection site reactions and may, over time, avoid lipoatrophy."
  May 2014 ,Medscape Medical News,Intensive Pain Rehab Improves Kids' Mental Health,An intensive interdisciplinary pain rehabilitation program that focuses on the individual needs of each child improves psychological functioning in kids with a variety of pain conditions.
  May 2014 ,Medscape Medical News,IL-2 for Kidney Cancer Offers Cure,"High-dose interleukin-2 is still a viable treatment option for metastatic renal cell carcinoma, because it is the only truly curative option for advanced disease."
  May 2014 ,Reuters Health Information,Brodalumab Meets Goals in Phase 3 Psoriasis Study,"A drug under development by Amgen Inc and AstraZeneca Plc met the goals of a Phase 3 study in patients with moderate-to-severe plaque psoriasis, the companies said on Friday."
  May 2014 ,Reuters Health Information,Dual Therapy Effective in Newly Diagnosed HIV-1 Infection,"In previously untreated adults with HIV-1 infection, dual therapy with lopinavir and ritonavir plus lamivudine is as effective as triple therapy with lopinavir and ritonavir plus two NRTIs."
  May 2014 ,Medscape Medical News,Parathyroid Hormone for Hypoparathyroidism: More Data,"Further phase 3 trial results of recombinant human parathyroid hormone in patients with hypoparathyroidism show that almost all can cut out vitamin D, and     58% eliminate both calcium and vitamin-D supplements."
  May 2014 ,Medscape Medical News,Macular Thinning on Fingolimod Treatment in MS,A recent study shows a decrease in macular volume with 1 year of treatment of patients with MS receiving fingolimod. Whether this decrease correlates with a loss of brain volume is not yet known.
  May 2014 ,Medscape Medical News,Thromboprophylaxis in Cancer Patients: Needs Rethink,"Most hospitalized cancer patients receive thromboprophylaxis, but clinicians urgently need better tools for determining which cancer patients are likely to benefit."
  May 2014 ,Medscape Medical News,Dabigatran Crosses Placenta in Ex Vivo Experiment,"With ex vivo data showing dabigatran can cross the placenta, its safety during pregnancy is questionable, researchers say. "
  May 2014 ,Medscape Medical News,"Ondansetron, Metoclopramide Similar in Head-to-Head Trial",Ondansetron is more expensive but no better than metoclopramide in treating morning sickness in pregnant women; women taking metoclopramide reported more minor adverse effects.
  May 2014 ,Medscape Medical News,Hospital-Acquired Conditions and Readmits on Downswing,"Medicare readmissions decreased again in 2013, and fewer hospital-acquired infections, falls, and drug mishaps in 2011 and 2012 saved almost 15,000 lives, according to HHS."
  May 2014 ,Heartwire from Medscape,Salt and Battery: Debate on Sodium Targets Gets Feisty," The PURE study suggests that low sodium intake is linked with increased cardiovascular risks, but the question of sodium targets is far from settled, with     a corresponding debate on the topic getting oddly personal."
  May 2014 ,Reuters Health Information,Methylprednisolone to Reduce Strictures After Esophageal Burns ,"High doses of methylprednisolone can reduce stricture formation after esophageal burns in children who ingest caustic substances, researchers from Turkey report."
  June 2014 ,Heartwire from Medscape,TESLA: Evolocumab Clears Hurdle in Homozygous FH," Added on top of a statin and ezetimibe, evolocumab reduced LDL cholesterol 23% compared with an 8% increase among the placebo-treated patients. Experts     hope the drug class can be used for hard-to-treat HoFH patients."
  June 2014 ,Medscape Medical News,Targeted Drug Combo Improves Outcomes in Ovarian Cancer,"The combination of 2 investigational drugs, olaparib and cediranib, holds promise as a nonchemotherapy approach to ovarian cancer."
  June 2014 ,Medscape Medical News,Sunday at ASCO: Hot News From Plenary Session,"The plenary session today will hear potentially practice-changing results in breast and prostate cancer, and reassuring results in colorectal cancer. "
  May 2014 ,Medscape Medical News,Friday at ASCO: Improving Quality of Life,"Oncology is not just about helping people to live longer, but also involves strategies that will improve patients' quality of life, says ASCO expert."
  May 2014 ,FDA Approvals,FDA Okays First Device for Restless Legs Syndrome ,"The FDA will allow marketing of the Relaxis pad (Sensory Medical Inc), a nonpharmacologic approach to improve sleep quality in RLS."
  May 2014 ,Medscape Medical News,Exercise Benefits of Caffeine Might Be Genetic,"Caffeine helps sedentary people become more active, but genetic differences could determine who will get an athletic boost, a pair of studies suggest."
  May 2014 ,Medscape Medical News,Acute Radiation Skin Toxicity Possible With BRAF Inhibitors,"Five cases point to a potential unanticipated interaction between BRAF inhibitors and ionizing radiation, leading to acute skin toxicity."
  May 2014 ,Medscape Medical News,Physical Therapy May Not Be Helpful for Osteoarthritis ,Physical therapy for patients with hip osteoarthritis was associated with mild temporary increases in pain in the hip or back that tended to resolve over time. 
  May 2014 ,Medscape Medical News,Tamoxifen for 10 Years an Option: ASCO Guideline Update,"Women with hormone receptor-positive breast cancer should consider taking tamoxifen for 10 years, ASCO says."
  May 2014 ,Medscape Medical News,Nintedanib Slows Idiopathic Pulmonary Fibrosis Progression,"The tyrosine kinase inhibitor slowed the decline in lung function over a year in 2 phase 3 trials, providing hope for another therapeutic option for these patients."
  May 2014 ,Medscape Medical News,Diabetes Drug Eyed as Obesity Treatment,"Already approved for the treatment of diabetes, the incretin mimetic liraglutide is now being investigated as a potential weight-loss drug."
  May 2014 ,FDA Approvals,FDA Clears Dalbavancin (Dalvance) for Acute Skin Infections,The antibacterial agent is the first designated as a Qualified Infectious Disease Product (QIDP) to receive FDA approval. 
  May 2014 ,Medscape Medical News,Few Hospices Providing CAM Services to Patients,"Only 29% of hospices in the United States employ complementary and alternative medicine (CAM) therapists for massage, music, or art therapy, despite the growing interest in these services."
  May 2014 ,International Approvals,"CHMP Endorses Peginterferon-Beta-1a, Not Laquinimod, in MS","After a second look at laquinimod, the EMA panel maintains that the benefits don't outweigh the potential risks of the drug. "
  May 2014 ,State Health Alerts,PFOS Detected in Pease Tradeport Water System, A new series of articles in Epilepsia examine the potential use of cannabidiol and medical marijuana in young patients with epilepsy.
  May 2014 ,Medscape Medical News,Experts Debate Use of Cannabis to Control Seizures,"When it comes to EHR adoption, physicians in large practices are outpacing soloists. The gap between primary care physicians and specialists has grown as well."
  May 2014 ,Medscape Medical News,"EHR Divide Is Widening Among Physicians, CDC Says","Even a single episode of binge drinking can cause bacterial leakage from the gut, which in turn can lead to the release of endotoxins in the bloodstream."
  May 2014 ,Medscape Medical News,Single Binge Drinking Episode Drives Systemic Toxicity,"A fifth of older people hospitalized for hypoglycemia will have died within a year, say the authors of a newly published study; they call for diabetes     treatment goals to be softened in these patients."
  June 2014 ,Heartwire from Medscape,Sausage Link? Heart-Failure Risk Higher with Processed Meats ,"That's not the wurst of it. While the incident heart-failure risk went up significantly with consumption of any form of processed meat, so did the risk of     heart-failure death--and more sharply."
  June 2014 ,Medscape Medical News,"Marijuana Tied to Addiction, Long-term Cognitive Dysfunction","Marijuana use is linked to several adverse effects, including addiction and long-term cognitive dysfunction."
  June 2014 ,Medscape Medical News,New ACS Guide for PCPs Managing Prostate Cancer Survivors,Detailed guidelines advise primary care physicians on medical and psychosocial aspects of survivorship.
  June 2014 ,Medscape Medical News,Levodopa Best Choice for Initial Parkinson's Treatment,"The largest ever drug trial in Parkinson's disease found that levodopa beats dopamine agonists and monoamine oxidase type B inhibitors in terms of patient-reported mobility, quality of life, and other measures."
  June 2014 ,FDA Approvals,FDA OKs First Topical Triazole Antifungal for Onychomycosis,Efinaconazole (Jublia) is the first triazole antifungal to be developed for the treatment of distal lateral subungual onychomycosis.
  June 2014 ,FDA Approvals,FDA Approves Bunavail for Opioid Addiction,The FDA has approved a new drug for the maintenance treatment of opioid dependence.
  June 2014 ,Medscape Medical News,What's Hot at EULAR 2014,"TNF-alpha inhibitors, biosimilars, and the IL-17 pathway are just a few of the topics on the EULAR program that have its scientific chair excited."
  June 2014 ,Medscape Medical News,Naloxegol Reduces Opioid-Induced Constipation ,"A new study shows naloxegol, a member of a class of agents that decreases gastrointestinal adverse effects without affecting analgesia, increases bowel movements."
  June 2014 ,Heartwire from Medscape,Few Breast-Cancer Patients With HF Referred to Cardiologists,"A new study puts the number of women with diagnosed HF or cardiomyopathy secondary to their breast-cancer treatments at 12%, yet only one-third are     promptly referred for a cardiology workup."
  June 2014 ,Medscape Medical News,Antidepressant-Related Weight Gain: Not All Agents Equal,Data for a 12-month period show modest differences in the amount of weight patients taking common antidepressant medications are likely to gain.
  June 2014 ,Medscape Medical News,"Stopping Statins Safe, Cuts Costs, in Terminal Patients",About $600 million could be saved if statins were stopped in every patient with less than a year's life expectancy; a new study shows such discontinuation is safe. 
  June 2014 ,Medscape Medical News,"Air Pollution Linked to Mixed, Small Health Effects ",UK researchers have found 'no clear evidence' of possible links between ambient air pollution and cardiovascular deaths in England and Wales.
  June 2014 ,Medscape Medical News,IV Theophylline Quickly Reduces Lumbar Puncture Headache,"A small study shows that the pain common after lumbar puncture or spinal anesthesia quickly resolves with IV theophylline, with the greatest relief in the first 30 minutes but continuing out to 60 minutes."
  June 2014 ,Medscape Medical News,"TAC, AC+T Linked to Higher Toxicity in Early Breast Cancer","Early-stage breast cancer patients under 65 had more hospitalizations after TAC or AC+T than after standard TC, and older patients had more hospitalizations after any regimen other than ddAC+P."
  June 2014 ,Medscape Medical News,Tapentadol is 'Third-Tier' Drug for Diabetic Neuropathic Pain,"Tapentadol improves the quality of life of patients with painful diabetic peripheral neuropathy, but because it is a narcotic and expensive, it is     relegated to a third-tier treatment, says one expert."
  June 2014 ,Medscape Medical News,Is Ipilimumab Useful for Earlier-Stage Melanoma?,A randomized placebo-controlled trial provides relapse-free survival results for patients with stage III disease.
  June 2014 ,Medscape Medical News,Life-Threatening Adverse Drug Reactions Likely to Recur,"Two serious skin conditions, Stevens-Johnson syndrome and toxic epidermal necrolysis, are rare, but had a high recurrence rate in a population-based cohort study. "
  June 2014 ,Medscape Medical News,Hope on Horizon for Newer Obesity Drugs in Europe?,The lack of obesity drugs in Europe was the focus of much discussion at the European   Conference on Obesity last week. Hopes are high that     bupropion/naltrexone and liraglutide will soon be approved there.
  June 2014 ,Medscape Medical News,Novel Compound Shows Promise in Diabetic Nephropathy,Emapticap pegol showed significant and sustained anti-inflammatory effects in diabetic nephropathy in a phase 2 trial.
  June 2014 ,FDA Approvals,"FDA OKs Aloxi for Chemo-Induced Nausea, Vomiting in Children","The FDA has approved palonosetron HCL (Aloxi, Eisai Inc and Hensinn Group) injection for the prevention of chemotherapy-induced nausea and vomiting in children aged 1 month to less than 17 years."
  June 2014 ,Medscape Medical News,Ketamine Metabolite Has Promise in Depression,Hydroxynorketamine may treat symptoms of depression without ketamine's unwanted side effects and also shows potential in neurodegenerative diseases such as Alzheimer's and Parkinson's.
  June 2014 ,Medscape Medical News,Psychotropic Drugs Can Reduce Bone Mass in Kids,A study has found that SSRIs and risperidone can have deleterious effects on bone mass formation and accrual in children who take these medications on a long-term basis.
  June 2014 ,Medscape Medical News,More on HF Hospitalization With Gliptins in Type 2 Diabetes,A new post hoc analysis of the VIVIDD study with the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes and heart failure has shown that the drug is not associated     with an increase in hospitalizations for HF.
  June 2014 ,Medscape Medical News,Third Meningococcal Vaccine Recommended for Children at Risk ,A third meningococcal vaccine is an additional option for children at increased risk for meningococcal disease. 
  June 2014 ,Reuters Health Information,A 4-Week Hep C Cure? Bristol to Test Drugs With Gilead's Sovaldi,"In the race to find a faster cure for hepatitis C, Bristol-Myers Squibb Co said it will test its experimental antiviral drug combination with Gilead Sciences Inc's blockbuster drug Sovaldi (sofosbuvir)."
  June 2014 ,Medscape Medical News,Hospitalization Rates Drop With LAIs in Schizophrenia,Switching patients with schizophrenia from oral antipsychotics to a long-acting injectable antipsychotic can result in a significant drop in rates of hospitalization for psychotic episodes.
  June 2014 ,FDA Approvals,New Antibiotic Tedizolid (Sivextro) Approved by FDA,Tedizolid phosphate is the second antibiotic for acute skin infections that the agency has okayed in the last 5 weeks.
  June 2014 ,Medscape Medical News,Ruxolitinib Provides New Benchmarks in Polycythemia Vera,The JAK1/JAK2 inhibitor improved signs and symptoms of the disease in a phase 3 trial.
  June 2014 ,Medscape Medical News,"Lithium, Quetiapine Equally Effective for Bipolar Disorder","Lithium and the second-generation antipsychotic quetiapine have similar efficacy, a real-world, head-to-head comparison shows."
  June 2014 ,Medscape Medical News,Attitudes Affect Adherence to Inflammatory Disease Meds,"For a range of chronic immune-mediated inflammatory diseases, patients' beliefs and concerns can influence how well they adhere to drug therapy, new research shows."
  June 2014 ,Medscape Medical News,Selumetinib Yields Modest Benefits in Rare Eye Cancer,The first randomized controlled trial of the MEK inhibitor selumetinib finds modest improvement in clinical outcomes of advanced uveal melanoma but high rates of adverse effects.
  June 2014 ,Medscape Medical News,No Added Cognitive Risk to Breast-Fed Kids of Moms on AEDs,"In a new report from the NEAD study, school-aged youngsters whose mothers took antiepileptic drugs while breast-feeding scored higher on IQ test than those whose mothers didn't breast-feed them."
  June 2014 ,Medscape Medical News,Thalidomide for Hemorrhagic Telangiectasia Epistaxis,"Partial or complete response is achieved with low-dose thalidomide when other therapies have failed; however, relapses are common."
  June 2014 ,Reuters Health Information,Shire to Test Its ADHD Drug in 4- to 5-Year-Olds in U.S.,Shire Plc has agreed to a U.S. Food and Drug Administration request to study its stimulant Vyvanse in preschool children as concern rises over the diagnosis and treatment of attention deficit hyperactivity disorder.
  June 2014 ,Medscape Medical News,BRAF Inhibitor Is Effective in Hairy Cell Leukemia,The drug could be important for the many patients who lose response or relapse with the most effective conventional therapies.
  June 2014 ,Medscape Medical News,Stopping Immunotherapy Possible in Some Patients With Lupus,Some patients with systemic lupus erythematosus who are in clinical remission with immunosuppressant therapy may be able to stop therapy without triggering a new disease flare.
  June 2014 ,Medscape Medical News,FDA Panel Debates CV Safety of Opioid Constipation Drugs ,An FDA advisory committee agreed that cardiovascular outcomes trials aren't necessary for an emerging class of drugs that decrease the gastrointestinal adverse effects of opioids without reducing analgesia.
  June 2014 ,Medscape Medical News,Screen for Hydroxychloroquine Retinopathy to Preserve Vision,Hydroxychloroquine retinopathy can cause damage that may continue for 3 or more years after the drug is discontinued and greatly reduce the amount of visual loss. 
  June 2014 ,Medscape Medical News,Natalizumab Continued Past 24 Months Safely in MS,Results from the TY-STOP observational study show patients with MS safely continued natalizumab past 24 months and had less disease activity vs going to a different drug or stopping all together.
  June 2014 ,Medscape Medical News,Study Finds Metformin Works Better in African Americans,"Findings from a large health system database suggest that, across several different analyses, glucose-lowering with metformin was consistently better among     African Americans compared with whites."
  July 2014 ,Medscape Medical News,Celecoxib May Reduce Pain After Face-lift,"The COX-2 inhibitor does not have the considerable adverse effects of opioids, but the cost is high, and insurance may not cover it. "
  July 2014 ,International Approvals,Canada OKs Aptiom as Add-On Therapy in Epilepsy,Eslicarbazepine (Aptiom) is indicated as adjunctive therapy for partial-onset seizures associated with epilepsy in adults who do not respond adequately to conventional therapy.
  July 2014 ,News Alerts,EU Restrictions on Bromocriptine for Inhibiting Lactation?,"The EMA committee has concluded that 'rare but potentially serious...cardiovascular, neurological, and psychiatric side effects cannot be ruled out.'"
  July 2014 ,Medscape Medical News,'Mississippi Baby' Thought 'Cured' of HIV Relapses,An infant who was seemingly cured of HIV now has detectable levels of the virus after 2 years without any evidence of the virus.
  July 2014 ,Medscape Medical News,Lung Societies Want Restrictions or Ban on e-Cigarettes,The Forum of International Respiratory Societies has called on governments to ban or restrict use of electronic cigarettes until their health effects are better understood.
  July 2014 ,Heartwire from Medscape,Naproxen CV Safety vs Ibuprofen Challenged in WHI Analysis,"Common perceptions about the CV safety of NSAIDs took a hit in a Women's Health Initiative study, but not everyone agrees with it."
  July 2014 ,Medscape Medical News,Tight Glycemic Control More 'Burden' Than Benefit for Many,"Benefits of tight glycemic control are often outweighed by treatment ""burden"" from side effects such as weight gain, hypoglycemia, or needing frequent     insulin injections, according to new research."
  July 2014 ,Medscape Medical News,Psychotherapy May Be Best Approach for Psychogenic Seizures,Psychotherapy that includes cognitive behavioral therapy and targets trauma and other issues may be the best treatment for patients with psychogenic seizures. 
  July 2014 ,Medscape Medical News,Steroid Epidural Injections No Benefit in Spinal Stenosis ,Epidural injection of glucocorticoids plus lidocaine offered minimal or no short-term benefit in the treatment of lumbar spinal stenosis.
  July 2014 ,Medscape Medical News,"In Utero Exposure to SSRI May Up Obesity, Diabetes Risk","New animal research suggests in utero exposure to fluoxetine may increase risk for metabolic disorders, including diabetes."
  July 2014 ,Reuters Health Information,Cryopreserved Testicle Tissue Used to Produce Baby Mice,Scientists have for the first time produced live offspring from testicle tissue that was cryopreserved and say a similar technique might one day be used to preserve the fertility of boys facing cancer treatment.
  July 2014 ,Medscape Medical News,Largest Study to Date: Transgender Hormone Treatment Safe ,"A multicenter study of more than 1500 patients receiving cross-sex hormone therapy for at least a year showed that most side effects were minor, providing     reassurance on safety."
  July 2014 ,WebMD Health News,Inhaled Insulin: What to Tell Patients,"Get ready to answer patients' questions about Afrezza, a new inhaled-insulin product."
  June 2014 ,Reuters Health Information,"With  Methotrexate Tx, Noninvasive Tests to Avoid Liver Biopsy","Noninvasive testing may be useful for spotting potential hepatotoxicity and confirming the need for liver biopsy in psoriasis patients on methotrexate sodium, according to Irish researchers who say more studies are needed."
  June 2014 ,International Approvals,EMA Panel Recommends Approval for Flutemetamol in AD ,The PET tracer received a positive opinion from the CHMP for detection of amyloid-beta neuritic plaques in the brain in diagnosis of patients suspected of having Alzheimer's disease.
  June 2014 ,International Approvals,EU Panel Gives Nod to Triple Combo Pill for HIV (Triumeq) ,"The EU’s Committee for Medicinal Products for Human Use has given a positive opinion for marketing of Triumeq, a once-daily combination of the antivirals dolutegravir, abacavir, and lamivudine. "
  June 2014 ,Medscape Medical News,T-DM1 Now Preferred for Progressive HER2 Breast Cancer,"T-DM1, a successor to trastuzumab, should be the preferred choice for HER2-positive breast cancer that has progressed despite multiple lines of treatment, new research shows."
  June 2014 ,Medscape Medical News,Omega-3 Fatty Acids Plus Inositol Promising in Pediatric BPD,"In this pilot double-blind RCT, combined treatment with omega-3 fatty acids and inositol reduced symptoms of mania and depression in young children with bipolar spectrum disorders."
  June 2014 ,Medscape Medical News,Anticholinergic Nasal Spray Eases Rhinorrhea in Parkinson's ,Rhinorrhea is common in Parkinson's disease but not well recognized or studied; anticholinergic nasal spray eases symptoms.
  June 2014 ,Medscape Medical News,FDA Panel Votes Against Accelerated Approval for Olaparib,An FDA advisory committee recommends waiting for phase 3 data before considering approval for olaparib as maintenance therapy for recurrent ovarian cancer.
  July 2014 ,News Alerts,"Ibrutinib in CLL: Indication Expanded, Benefit Confirmed ",The FDA has extended the use of the drug to also cover use in patients with chronic lymphocytic leukemia (CLL) with a chromosome 17p deletion.
  July 2014 ,Medscape Medical News,"Whistleblower Case Against Celgene Can Proceed, Says Judge",A former employee alleges that Celgene engaged in unlawful marketing of thalidomide and lenalidomide and downplayed risks before the drugs were approved to treat cancer.
  July 2014 ,Medscape Medical News,Oral Hepatitis C Drugs Helping Patients Coinfected With HIV,Results from TURQUOISE-1 and PHOTON-2 show that interferon-free regimens are achieving impressive response rates with few adverse events in patients coinfected with hep C and HIV.
  July 2014 ,Medscape Medical News,Type 1 Diabetes: No Delay With Low-Dose Otelixizumab ,Low-dose otelixizumab was safe but did not preserve beta-cell function in patients with newly diagnosed type 1 diabetes in a phase 3 trial; GSK has started a new dosing study. 
  July 2014 ,Medscape Medical News,Botox Helps Overactive Bladder Beyond 2 Years,"In the first long-term study of Botox for overactive bladder, efficacy and safety persisted for a median of 2.4 years with no additional safety issues, report researchers."
  July 2014 ,Heartwire from Medscape,HDL-Raising Drugs: No Value in the Statin Era?,"In the era of widespread statin use, investigators say studies testing fibrates, niacin, and CETP inhibitors do not support raising HDL         pharmacologically to reduce clinical outcomes."
  July 2014 ,Medscape Medical News,Real-World PrEP Use Protects Against HIV,"An extension trial shows the uptake of pre-exposure prophylaxis (PrEP) is high and effective, even without daily adherence."
  July 2014 ,Medscape Medical News,Mifepristone in Cushing's Disease: Long-term Results,"Tumor progression rate lower than expected after a median 11-month treatment with the glucocorticoid receptor antagonist to control hyperglycemia,         report study authors."
  July 2014 ,Reuters Health Information,African Americans With Cancer Pain More Likely to Receive Morphine,"African Americans with cancer pain are more likely than similar white patients to receive morphine, with 3- and 6-glucuronide neurotoxic metabolites that accumulate in chronic kidney disease (CKD), and less likely to receive oxycodone."
  July 2014 ,News Alerts,Mislabeling Prompts Recall of Ibuprofen and Oxcarbazepine Tablets ,American Health Packaging recalls 1 lot of ibuprofen and 1 lot of oxcarbazepine in 100-count cartons distributed to US hospitals nationwide.
  July 2014 ,Medscape Medical News,Sleep Deprivation Mimics Psychosis,"After being kept awake for 24 hours, healthy, sleep-deprived individuals exhibit response deficits that are key markers of schizophrenia."
  July 2014 ,Medscape Medical News,Mental-Health Risks of Diabetes Underrecognized,"Despite the increased risk for depression, anxiety, and eating disorders among diabetic patients, few clinics offer even basic mental-health screening with     diabetes treatment."
  July 2014 ,Medscape Medical News,Inhaled Steroids May Suppress Growth in Children With Asthma,"Inhaled corticosteroids may suppress growth in the first year of treatment in children with asthma, but lower doses may minimize the effects, according to 2 Cochrane reviews."
  July 2014 ,Medscape Medical News,"ADHD Drugs Not Tested for Safety, Efficacy Over Time",A review of ADHD clinical drug trials shows the majority of studies were too small and too short to effectively assess long-term safety and efficacy of the agents or detect rare adverse events.
  July 2014 ,Medscape Medical News,CLARINET Results: Lanreotide First Line for Metastatic NETs,"The somatostatin analogue lanreotide has shown antitumor benefits in many types of metastatic neuroendocrine tumors (NETs), including intestinal tumors. "
  July 2014 ,Heartwire from Medscape,"HPS2-THRIVE: As Niacin Fails, HDL's Role Is  Debated Anew","UPDATED // Given the negative results from AIM-HIGH and HPS2-THRIVE, as well as other negative studies, the cardiovascular research community is grappling with the     future of managing HDL-cholesterol levels to reduce clinical risk."
  July 2014 ,Medscape Medical News,Another Injectable Treatment for Diabetes on the Horizon," Enticing findings with fibroblast growth factor in mice suggest an insulin-sensitizing role, independent of mitogenic effects, with the potential to     normalize blood glucose with few side effects."
  July 2014 ,Reuters Health Information,IL-17 Inhibition May 'Change Paradigm' of Psoriasis Treatment,"The selective interleukin-17 (IL-17) inhibitor secukinumab (Novartis) produced rapid, robust and, with continued treatment, long-lasting relief of moderate to severe plaque psoriasis in two phase 3 studies."
  July 2014 ,Medscape Medical News,Novel Tamoxifen Gel Could Reduce Adverse Effects,"A tamoxifen gel applied directly to the breast produces antiproliferative effects similar to those produced by oral tamoxifen, but with fewer systemic effects."
  July 2014 ,Medscape Medical News,"No Evidence, Yet ADT Often Used in Localized Prostate Cancer","Androgen-deprivation therapy (ADT) is not associated with improved survival in men with localized prostate cancer, yet it is frequently used."
  August 2014 ,Medscape Medical News,Antipsychotics Linked to Acute Kidney Injury,"Use of atypical antipsychotic medications may increase the risk for acute kidney injury in elderly patients, causing researchers to call for their use in this population to be reevaluated. "
  August 2014 ,Medscape Medical News,Sclerosis: Autologous Cell Transfers May Help Patients,A new study has found that injections of adipose-derived stromal cells into the fingers of patients with systemic sclerosis decreased pain and increased function.
  August 2014 ,Medscape Medical News,Dairy Saturated Fats Lower Type 2 Diabetes Risk,"In a new study, the incidence of type 2 diabetes was found to differ depending on the type of saturated fatty acid consumed. Dairy fats appeared to be     protective."
  August 2014 ,Medscape Medical News,Getting a Good Day's Sleep,"Melatonin may extend daytime sleep in night shift workers and certain stimulants may increase alertness, a new review shows."
  August 2014 ,Medscape Medical News,Retina Specialists Report Problems With Ocriplasmin,"Many patients suffer adverse effects after treatment with ocriplasmin for vitreomacular adhesion, a survey of specialists finds."
  August 2014 ,Kaiser Health News,Stigma Is a Side-Effect of HIV-Prevention Medicine,Truvada is a drug that can help people who are not infected avoid contracting the virus that causes AIDS. But some patients are worried the medical community is not up to speed. 
  August 2014 ,Medscape Medical News,Switching Antiretrovirals May Not Enhance HIV Treatment,"Changing treatment when the viral load is suppressed can increase the risk for subsequent virologic failure, new research shows."
  August 2014 ,Medscape Medical News,Gamma Knife Brain Surgery Promising for Severe OCD,"Gamma ventral capsulotomy, a type of ablative brain surgery, for intractable obsessive-compulsive disorder shows promise according to results from the first randomized, double-blind trial."
  August 2014 ,Medscape Medical News,Best Treatment for Shoulder Pain?,"Physical therapy is just as effective as corticosteroid injections in alleviating pain and disability and improving quality of life, and may be less costly."
  August 2014 ,Medscape Medical News,Obesity Drug Safety Debate Escalates in Medical Journal ,Arguments and accusations fly as physicians and others debate the FDA's wisdom in approving lorcaserin and phentermine-topiramate.
  August 2014 ,FDA Approvals,FDA Expands Approval of Pompe Disease Drug,"On the basis of new data available since the approval of Lumizyme, the FDA has expanded approval to include patients younger than 8 years, as well as eliminating the REMS program attached to the drug."
  August 2014 ,Heartwire from Medscape,"Post-Beta-Blocker Flap, New CV Guidance for Non-CV Surgery","The ESC/ESA and ACC/AHA issue new recommendations for the cardiovascular management of patients undergoing noncardiac surgery, including how to use     beta-blockers in the post-DECREASE era."
  August 2014 ,Medscape Medical News,"Treatment for CLL: Change Aplenty, More Coming",A new review looks at what clinicians should be doing right now in the management of chronic lymphocytic leukemia (CLL).
  July 2014 ,FDA Approvals,FDA Clears Olodaterol (Striverdi Respimat) for COPD,"The once-daily inhaled long-acting beta-agonist is for long-term maintenance treatment of airflow obstruction in patients with COPD, including chronic bronchitis and/or emphysema."
  July 2014 ,Medscape Medical News,"US Cigar Smoking Doubles, Variety of Products Available","In the United States, cigarette consumption declined during 2000 to 2011, but consumption of cigars more than doubled during the same period, according to the CDC. "
  July 2014 ,Medscape Medical News,"One-Dose Antiemetic Eases Chemo-Induced Nausea, Vomiting",A single oral dose of netupitant plus palonosetron at the beginning of a chemotherapy cycle prevented nausea and vomiting for most cancer patients.
  July 2014 ,Medscape Medical News,Teenagers With Cancer at Risk for Severe Menstrual Bleeding,"Cancer treatment can put teenage girls at high risk for heavy menstrual bleeding, so new guidelines suggest that gynecologists should be involved in their care."
  July 2014 ,Medscape Medical News,Musculoskeletal Pain on Stopping Imatinib: Should We Worry?,A first report on a withdrawal syndrome documents patients with chronic myelogenous leukemia with musculoskeletal pain after imatinib withdrawal.
  July 2014 ,Reuters Health Information,Apremilast Shows Promise for Inflammatory Rosacea,"The oral phosphodiesterase inhibitor apremilast relieves signs of inflammatory rosacea, according to a pilot study in patients with moderate to severe disease."
  July 2014 ,Medscape Medical News,Physicians Pose Barriers to Urinary Incontinence Treatment,"In focus groups, insured women with urinary incontinence cited barriers to treatment, including fear of treatment, lack of knowledge, and physician insensitivity to the problem."
  August 2014 ,Reuters Health Information,Oral Sea Buckthorn Oil to Maintain Post-menopausal Vaginal Health,"Sea buckthorn oil taken orally can help improve vaginal atrophy in postmenopausal women, a new randomized trial suggests."
  September 2014 ,Heartwire from Medscape,"PARADIGM-HF: Some Say, 'A New Day in Heart Failure'"," ""I'm having difficulty being critical of this one,"" said one expert on the trial of an agent tailor-made to supplant ACE inhibitors for heart failure. But     is this just the honeymoon phase?"
  August 2014 ,Reuters Health Information,IV Lidocaine an Option for Critical Limb Ischemia Pain,Intravenous lidocaine proved better than IV morphine in alleviating pain due to critical limb ischemia in a randomized double-blind controlled trial conducted in Iran.
  August 2014 ,Heartwire from Medscape,Huge Decreases in LDL Cholesterol With Alirocumab: ODYSSEY,"Tested in high-risk CVD patients, heterozygous-FH patients, and patients intolerant to statins, treatment with alirocumab resulted in as large as a 60%     reduction in LDL cholesterol from baseline. Some patients even got down to LDLs of 50 mg/dL."
  August 2014 ,Heartwire from Medscape,"COPPS-2: Colchicine Stops Postop Pericarditis, Troubles Gut","In COPPS-2, patients taking colchicine had a high rate of adverse GI events, and this likely explains why there was no overall benefit in preventing AF     after cardiac surgery; but it was effective for pericarditis  of postpericardiotomy syndrome."
  August 2014 ,Heartwire from Medscape,PARADIGM-HF: New Drug Class Outclasses ACE-I in Chronic HF ,"Although observers are cautious, one expert writes hopefully that the trial ""may well represent a new threshold of hope for patients with heart failure."""
  August 2014 ,Reuters Health Information,Wanted: 60 Volunteers to Test Ebola Vaccine in Middle England,Fancy testing an Ebola vaccine? It may sound scary but the scientist behind the British trial of a shot that has so far only been given to monkeys sees little risk and is optimistic he will drum up enough volunteers.
  August 2014 ,Reuters Health Information,Getting Help for Postpartum Depression for Uninsured Women,"Women who lose their health insurance in the postpartum period find it hard to get mental health care for postpartum depression, new research shows."
  August 2014 ,Medscape Medical News,What's Going to Be Hot at ERS 2014,"First results from AMBITION, the large pulmonary arterial hypertension trial, will be presented along with the latest strategies for treating asthma and chronic obstructive pulmonary disease."
  August 2014 ,Medscape Medical News,TMS Improves Memory via Brain Surface Networks,"Repetitive transcranial magnetic stimulation improves memory by targeting surface regions connected with the much deeper center of memory, the hippocampus."
  August 2014 ,Medscape Medical News,Complication Rate No Higher With DBS in Older PD Patients,"Neurologists may still be reluctant to refer older patients with Parkinson's disease for deep brain stimulation for fear of surgical complications, but a new study suggests this fear is unfounded."
  August 2014 ,Heartwire from Medscape,Self-Monitoring and Titration of Meds Drops BP in TASMIN SR,"Twelve-month findings from a small, unblinded trial offer support for a strategy of having hypertensive patients keep tabs on their own blood pressure and     adjust their drugs as needed."
  August 2014 ,International Approvals,Daclatasvir (Daklinza) for Chronic Hepatitis C Cleared in EU,"The potent oral antiviral, indicated across multiple HCV genotypes and in combination with other oral drugs, yields cure rates of up to 100%, the manufacturer says. "
  August 2014 ,Medscape Medical News,WHO Calls for Strict Global Regulation of e-Cigarettes,"The WHO is calling for global regulation of e-cigarettes and similar devices as public health concerns gain momentum, especially as they affect youth and nonsmokers."
  August 2014 ,Medscape Medical News,Medical Marijuana Laws Linked to Fewer Opioid Deaths,A new study finds lower rates of death from accidental overdose of analgesic opioids in states where laws provide access to medical marijuana.
  August 2014 ,Medscape Medical News,"Ebola Therapies and Vaccines Need Priority, Support ",Editorials published this week by major infectious disease experts call for support and prioritizing development of Ebola therapies and vaccines while maintaining momentum in controlling the outbreak. 
  August 2014 ,Medscape Medical News,MRSA: Experts Question the Value of Some Control Precautions,Some European infectious disease experts have questioned the value of contact isolation and screening for controlling MRSA.
  August 2014 ,Medscape Medical News,Skin Reactions to Phenytoin Linked to Gene Variants,"Carriers of a genetic variant linked to reduced drug clearance have more than 10 times higher odds of developing adverse skin reactions to the antiepileptic drug, suggesting screening may flag risk."
  August 2014 ,Medscape Medical News,Glaucoma Drug Eyed as Novel Diabetes Treatment 'Archetype',"An old glaucoma drug, methazolamide, improved glucose control in a small study, probably due to a distinct mechanism that the manufacturer, Verva, hopes to     pursue."
  August 2014 ,Reuters Health Information,Jury Out on Histamine-2 Receptor Antagonists for Pediatric GERD,"There is little high-quality evidence to support the efficacy and safety of histamine-2 receptor antagonists (H2RAs) for pediatric gastroesophageal reflux disease (GERD), researchers said."
  September 2014 ,Medscape Medical News,Patient Expectations Largely Dictate Antidepressant Response,"Expectations about antidepressant efficacy largely dictate response to treatment in depression, as outcomes between active treatment and placebo are modest at best."
  September 2014 ,Medscape Medical News,Vitamin D Doesn't Prevent Calcium Drop After Gastric Bypass,"Sharp decreases in calcium absorption were observed even when gastric bypass patients maintained adequate vitamin D levels, with the level of decline     correlating with the percentage of weight loss."
  September 2014 ,Medscape Medical News,Generic GA Shows Equivalence on MRI Endpoints in MS,A generic version of the MS drug glatiramer acetate looked similar to the branded product (Copaxone) in terms of reduction in MRI lesions and side effects in the GATE study.
  September 2014 ,Medscape Medical News,Adjunctive ECT Effective for Drug-Resistant Schizophrenia,Augmenting clozapine-resistant schizophrenia with electroconvulsive therapy is a safe and effective treatment option.
  September 2014 ,Medscape Medical News,'Most Powerful' Combo for Type 2 Diabetes Fulfills Promise,"The combination of a GLP-1 agonist and basal insulin produces remarkable results in type 2 diabetes, say the authors of a new meta-analysis and     accompanying comment. But cost remains a concern."
  September 2014 ,Medscape Medical News,First US Study of Mesenchymal Stem Cells in MS   ,"The phase 1 study established safety, and while it was not designed to look at efficacy, there were some 'enticing hints of benefit' in individual patients, the lead investigator said. "
  September 2014 ,Medscape Medical News,"Osteoporosis Drugs Lower Fracture Risk, but Best One Unclear ","There are very few head-to-head trials of pharmacologic treatments for osteoporosis; thus, reviewers are left to summarize trials and observational studies of individual drugs. "
  September 2014 ,Medscape Medical News,UK's NICE: No to Nab-Paclitaxel for Pancreatic Cancer,The draft guidance says that the benefits of nab-paclitaxel plus gemcitabine in metastatic pancreatic cancer do not outweigh its high costs.
  September 2014 ,FDA Approvals,FDA OKs Menactra as Booster Against Meningococcal Disease ,"Menactra (Sanofi Pasteur) is indicated in individuals 15 to 55 years of age for booster vaccination against meningococcal disease caused by Neisseria meningitidis serogroups A, C, Y, and W-135."
  September 2014 ,Medscape Medical News,Brief Scale Linked to Antidepressant Overprescribing,"Using brief depression symptom measures, especially the PHQ-9, may lead to overdiagnosing and subsequent unnecessary prescribing unneeded antidepressants for those at low risk for the disorder."
  September 2014 ,Medscape Medical News,Question Drug Prescribing in Advanced Dementia,"More than half of nursing home residents with advanced dementia receive medications of questionable benefit, at 'substantial' personal and monetary cost, a new study shows. "
  September 2014 ,Medscape Medical News,Opioid-Induced Adverse Effects Hit Social Media,"Social media analysis reveals patients are talking about constipation and other opioid-induced adverse effects, and about lack of communication with doctors."
  September 2014 ,Medscape Medical News,Statins Don't Up Diabetic Microvascular Disease Risk,An analysis of a large database in Denmark suggests that statin use among adults who later develop diabetes does not raise the risk for microvascular     complications and may even protect against them.
  September 2014 ,Medscape Medical News,Benzodiazepines Linked to Increased Alzheimer's Risk,"Use of benzodiazepines for insomnia and anxiety, especially over the long term, may increase the risk for Alzheimer's disease."
  September 2014 ,Reuters Health Information,French Company Carmat Fits Second Patient With Artificial Heart,French company Carmat said on Monday it had fitted a second patient with one of its artificial hearts and would continue clinical trials on two more patients.
  September 2014 ,Medscape Medical News,The Opioid Constipation 'Disconnect',Doctors and patients have differing views on the impact of opioid-induced constipation and use of laxatives to relieve this adverse effect.
  September 2014 ,Medscape Medical News,Rapid Streptococcus Tests Accurate,A metaanalysis has suggested that rapid streptococcus tests are accurate and may not need confirmation with throat culture.
  September 2014 ,Medscape Medical News,Quadruple Dosing of Doripenem Safe in Patients With CF,"High doses of the antibiotic doripenem are safe to use in patients with cystic fibrosis suffering from acute respiratory infection, report investigators."
  September 2014 ,FDA Approvals,FDA Okays First PD Inhibitor: Pembrolizumab for Melanoma,"The first of a new class of programmed death (PD) inhibitor drugs has been approved in the United States, much earlier than expected."
  September 2014 ,Medscape Medical News,"No Bladder-Cancer Risk With Pioglitazone, Says Takeda ",Takeda has submitted new data to regulatory authorities worldwide that it says show there is no bladder-cancer risk with its diabetes drug pioglitazone.
  September 2014 ,Medscape Medical News,Alemtuzumab for MS: Encouraging 4-Year Data ,"Latest data continue to show low rates of relapse and new lesions, with brain atrophy said to be slowed to 'almost normal.'  But safety issues are still a concern for some. "
  September 2014 ,Heartwire from Medscape,K-Binder Averts Hyperkalemia Over One Month: Top-Line Results,"A phase 3 trial of the potassium sequestrant ZS-9 met its primary end point by averting recurrent hyperkalemia compared with placebo, said ZS Pharma in a     short announcement."
  September 2014 ,Medscape Medical News,Single Radiation Dose for Malignant Spinal Cord Compression,"A single but higher dose of radiation preserves mobility in patients, and is cheaper and more convenient than lower doses given over several days. "
  September 2014 ,Medscape Medical News,"Odanacatib Efficacy Stays Strong, Side Effects Give Pause",Results from the phase 3 LOFT trial show robust reduction in fracture risk but small yet alarming increases in stroke; atypical fractures prompt a closer     look.
  September 2014 ,International Approvals,Idelalisib (Zydelig) Approved in Europe,The first-in-class oral agent is now approved in the EU for the treatment of chronic lymphocytic leukemia and follicular lymphoma.
  September 2014 ,Medscape Medical News,Synthetic Marijuana Now a Worldwide Problem,"Consumption of synthetic cannabinoids, aka K2 or Spice, has increased all over the world - despite law enforcement and regulatory control measures, reports a new NIDA-led study."
  September 2014 ,Medscape Medical News,Probiotics Cut Autoimmunity 33% in Infants at Risk for Diabetes,"Probiotics given to infants under 3 months of age appear to reduce the incidence of islet-cell autoimmunity by one-third, according to early results from     the ongoing TEDDY trial in the United States and Europe."
  September 2014 ,Medscape Medical News,Childhood Trauma Heightens Disease Risk Into Adulthood,"Exposure to family dysfunction, abuse, and neglect as children can increase risk for most of the leading causes of death in the US, a pediatrician warns. Her practice starts with routine screening."
  September 2014 ,Medscape Medical News,"In Search for Beauty, Some Find Vision Loss",Patients injected with subcutaneous dermal fillers may be at risk for occlusion of ocular arteries leading to transient or potentially permanent vision loss.
  September 2014 ,Medscape Medical News,What's Hot at ESMO 2014,"New data promise to be practice changing, and will change the standard of care for melanoma, prostate, and lung cancer, among others."
  September 2014 ,Medscape Medical News,Early Azithromycin in Infants Risks Pyloric Stenosis,"Infants who receive azithromycin within the first days of life have an 8-fold increase in risk of developing hypertrophic pyloric stenosis, report researchers."
  September 2014 ,Reuters Health Information,First UK Volunteer Gets GSK Ebola Vaccine in Trial,"The first volunteer in a fast-tracked British safety trial of an experimental Ebola vaccine made by GlaxoSmithKline received the injection on Wednesday, trial organizers said."
  September 2014 ,Medscape Medical News,'Real-World' Study Shows Two Drugs Better Than One for COPD ,"Patients with asthma or who  were not taking long-acting anticholinergics derived especially good benefit, investigators say. "
  September 2014 ,Medscape Medical News,Empagliflozin Useful Second-Line for Diabetes vs Glimepiride,  The SGLT2 inhibitor empagliflozin provided favorable results at 2 years compared with the sulfonylurea glimepiride when used as second-line     therapy after metformin in diabetes.
  September 2014 ,Reuters Health Information,Ebola Vaccine Trial Finds 'No Red Flags': U.S. Senate Testimony,"A key safety trial of an experimental Ebola vaccine manufactured by GlaxoSmithKline has injected 10 healthy volunteers since Sept. 2, and so far 'no red flags' indicating serious adverse reactions have been found."
  September 2014 ,FDA Approvals,FDA Okays Naloxegol (Movantik) in Opioid-Induced Constipation,Approval comes following results of 2 studies showing the drug is safe and effective.
  September 2014 ,Medscape Medical News,ASTRO Issues More 'Don't' Recommendations,The radiation oncology organization has a new set of 5 practices that should be stopped or only used occasionally.
  September 2014 ,Medscape Medical News,Urinary Incontinence: ACP Offers Nonsurgical Options ,"A new American College of Physicians guideline suggests nonsurgical treatment options for women with urinary incontinence, including Kegel exercises, bladder training, weight loss, and exercise. "
  September 2014 ,Medscape Medical News,Daclizumab in MS: More Detail on Phase 3 Results," Full final results of the DECIDE trial show 'impressive efficacy and manageable safety,' with daclizumab HYP, the lead investigator reports. "
  September 2014 ,Medscape Medical News,Two Drugs Better Than One for Pulmonary Hypertension,New data from the AMBITION trial suggest that combining ambrisentan with tadalafil cuts clinical failure in pulmonary hypertension by 50% compared with either drug alone.
  October 2014 ,Medscape Medical News,Egg-Rich Diet Not Harmful in Type 2 Diabetes,A new Australian study explores the differences in lipid levels seen between type 2 diabetes patients randomized to a diet low in egg consumption (less     than 2 eggs per week) vs high (12 per week).
  October 2014 ,Reuters Health Information,Long Flights and Patients at Risk for Acute-Closure Glaucoma,"Patients with risk factors for acute-closure glaucoma may consider taking special precautions on long flights, researchers suggest."
  October 2014 ,Medscape Medical News,CBT Trumps Medications for Social Anxiety,One-on-one cognitive-behavioral therapy appears to be more effective than pharmacotherapy for treating social anxiety disorder.
  October 2014 ,Medscape Medical News,Drug Reactions Largest Factor in Fatal Anaphylaxis,"Drugs, foods, and venom accounted for most deaths from anaphylaxis. "
  October 2014 ,Heartwire from Medscape,Beta-Blockers No Use in CAD Patients With No Prior MI,"Beta-blocker use in stable CAD or in patients with CAD risk factors only had no benefits and may have increased stroke risk in CHARISMA. ""We can't lump     all CAD patients together,"" one expert says."
  October 2014 ,Medscape Medical News,"Bad News, Good News for Fibromyalgia Drug",A new sublingual drug that targets nonrestorative sleep failed to lessen daily pain in fibromyalgia patients but did improve sleep quality and lessen overall symptomatic burden.
  September 2014 ,FDA Approvals,FDA Okays Methylnaltrexone (Relistor) for Opioid Constipation,The makers of Relistor announced approval of an expanded indication for this previously approved drug in treatment of opioid-induced constipation. 
  September 2014 ,Medscape Medical News,Peripheral Neuropathy Treatment Taps Into Quantum Theory ,Peripheral Neuropathy Treatment Taps Into Quantum Theory 
  September 2014 ,Medscape Medical News,Long-Acting Reversible Contraceptives Best Choice for Teens,New AAP guidelines for teenaged pregnancy prevention now recommend long-acting reversible contraceptives as first-line contraception for teenagers who are  sexually active.
  September 2014 ,Medscape Medical News,New AAN Position Statement on Opioids for Noncancer Pain,"In a new position paper, the American Academy of Neurology responds to an urgent public health problem, suggesting that for many pain conditions the risks likely outweigh the benefits."
  September 2014 ,Reuters Health Information,Scientists Grapple With Ethics in Rush to Release Ebola Vaccines,"Normally it takes years to prove a new vaccine is both safe and effective before it can be used in the field. But with hundreds of people dying a day in the worst ever outbreak of Ebola, there is no time to wait."
  September 2014 ,Medscape Medical News,'Impressive' Duration of Response With Nivolumab in Melanoma,Preliminary data from the first phase 3 trial with the immunotherapy nivolumab show that most patients who respond continue to respond (up to 10 months). 
  September 2014 ,Medscape Medical News,EU Panel Likes 4 New Cancer Products,"The EMA's CHMP has recommended a new drug for non-small cell lung cancer and one for gastric cancer, a new drug for chemotherapy-induced neutropenia, and a new imaging product."
  September 2014 ,International Approvals,CHMP Backs Naloxegol (Moventig) in Opioid-Induced Constipation,"On the heels of its US approval, European regulators have recommended approval of naloxegol for opioid-induced constipation in adults who fail laxatives. "
  September 2014 ,Medscape Medical News,Laquinimod in MS: Latest Safety Data 'Reassuring' ,The latest pooled data from the extension phases of the major phase 3 studies show no new adverse effects and no signal of any type of cancer. 
  September 2014 ,Medscape Medical News,"Metformin in Diabetes: Evidence Overwhelming, or Unclear? ","The drug is old and widely used for type 2 diabetes, but disagreement exists as to whether the data support its use; 2 experts at EASD faced off in a     lively debate."
  September 2014 ,Heartwire from Medscape,"Diabetes Is On-Target Effect of Statins, Genetic Study Finds","Scientists say they have found a partial explanation as to why statins might up the risk of developing diabetes and, importantly, that the diabetogenic effects may not be easily disentangled from the LDL benefits."
  September 2014 ,Medscape Medical News,Stepwise Stages Critical When Tapering Pain Meds ,"Go slow, give encouragement, and consider the substantial neuroplastic changes that occur as patients break free from a pain management regimen based solely on medication, a new withdrawal approach suggests."
  September 2014 ,Heartwire from Medscape,Failed HCV Drug Cardiotoxic in 40% of Treated Patients,"When analyzing the 34 patients treated with BMS-986094, researchers found that 14 had some form of systolic dysfunction. Those cases of low LVEF might have     remained undetected, given that troponin and BNP levels were relatively normal."
  September 2014 ,Medscape Medical News,"Most Vaccination-Onset Epilepsy Has Genetic, Structural Cause","A new study shows that most seizures beginning after vaccination have an underlying genetic or structural cause, which should increase faith in vaccine safety, researchers say."
  October 2014 ,Medscape Medical News,Soy Isoflavones: No Evidence of Endometrial Harm at 3 Years,A study that found soy isoflavone supplements ineffective in preventing bone loss now shows that at least they do not appear harmful over the long term.
  October 2014 ,Medscape Medical News,Solution to US Cancer Care 'Crisis' Is Less Cancer Care,"There is a need to revise the disease-centric approach that requires that all cancers be treated, regardless of age, comorbidities, and likely side effects. Overall well-being should be paramount, say a pair of reformers."
  October 2014 ,Medscape Medical News,Synthetic Marijuana Emergency Visits More Than Double,The number of ED visits involving synthetic marijuana products has risen exponentially.
  October 2014 ,FDA Approvals,FDA Approves Two Drugs for Idiopathic Pulmonary Fibrosis ,The US Food and Drug Administration has approved nintedanib (Ofev) and pirfenidone (Esbriet) for the treatment of idiopathic pulmonary fibrosis.
  October 2014 ,Medscape Medical News,Breathing and Awakening Trials Cut Ventilator Complications,"For patients in intensive care, ventilator-associated events can be avoided with spontaneous awakening and breathing trials, say researchers."
  October 2014 ,Reuters Health Information,Significant Retinopathy Risk With Long-Term Hydroxychloroquine,"Long-term use of hydroxychloroquine may carry a significant risk of toxic retinopathy, according to a retrospective case-control study."
  October 2014 ,Medscape Medical News,"Alcohol Intake Tied to Low Sperm Quality, High Testosterone",Men who drank 40+ units of alcohol per week had 34% lower sperm concentration than those who drank 5 or fewer units.
  October 2014 ,Medscape Medical News,"Restrict Valproate, EMA Committee Urges",A European Medicine Agency's committee recommends strengthening the restrictions on the use of valproate in women of childbearing age.  
  October 2014 ,Medscape Medical News,e-Cigarettes Have Secondhand Adverse Effects,Adverse-event reports to the US Food and Drug Administration about e-cigarettes from nonusers include respiratory complaints that could be related to nicotine toxicity.
  October 2014 ,Medscape Medical News,Intravenous Ibuprofen Reduces Childhood Fever,"Previously untested in pediatric populations, an IV formulation of ibuprofen could be an effective alternative for children who can't take oral medication."
  October 2014 ,Medscape Medical News,Conference to Headline 'Remarkable Success' in GI Medicine,Innovations in the treatment of hepatitis C will be highlighted at the meeting.
  October 2014 ,Medscape Medical News,EMA Finds Little Evidence That Testosterone Ups CV Risk,But the EU agency's committee still rules that labels of testosterone-containing products should be updated.
  October 2014 ,Medscape Medical News,Wide Utility of Model Predicting Troglitazone Hepatotoxicity ,What if scientists could predict adverse events of drugs in development that may not show up in animal studies or the relatively limited clinical testing     that goes on preapproval?
  October 2014 ,Medscape Medical News,Diabetic Neuropathy Pain: Mirogabalin Promising in Pilot Study,"The first serious look at mirogabalin by ""top notch"" investigators offers food for thought in the treatment of painful peripheral diabetic neuropathy."
  October 2014 ,Medscape Medical News,Cancer Drugs Fund in England: Plugging a Gap in Cancer Care,"The fund provides cancer patients access to targeted agents deemed too expensive by the National Cancer of Clinical Excellence, but is it really only a temporary solution?"
  October 2014 ,Reuters Health Information,NSAIDs May Boost Risk of Venous Thromboembolism,"Pooled data from observational studies show a significantly increased risk of venous thromboembolism (VTE) among NSAID users versus nonusers, according to U.S. and Thai researchers."
  October 2014 ,Medscape Medical News,Promising New Drug for Migraine Prevention,A genetically engineered antibody is showing great promise for migraine prevention. 
  October 2014 ,Medscape Medical News,"Fibromyalgia: Memantine Reduced Pain in Small, Blinded Trial","Memantine, an agent primarily used to treat patients with Parkinson's or Alzheimer's disease, may provide pain relief and improve the quality of life of patients with fibromyalgia."
  October 2014 ,Medscape Medical News,'Medical Food' Bests Ibuprofen in Chronic Low Back Pain,"Study showed theramine, an amino acid blend, alone or combined with ibuprofen is better than ibuprofen alone in patients with chronic low back pain."
  October 2014 ,Medscape Medical News,Evidence Linking Some Fluoroquinolones to Uveitis Grows,Moxifloxacin or ciprofloxacin appear to increase the risk for uveitis; levofloxacin less so. 
  November 2014 ,Medscape Medical News,Sofosbuvir/Ledipasvir Combo Effective for Relapse HCV,Researchers have found sofosbuvir/ledipasvir to be effective for treating patients with relapsed HCV infection.
  November 2014 ,Medscape Medical News,New Psychotropic Drug Classification System Unveiled,A newly proposed naming system for reclassifying psychotropic drugs has been unveiled in Europe with plans for a worldwide rollout in the near future.
  October 2014 ,Reuters Health Information,COX-2 Inhibitors for Rheumatological Manifestations of IBD,"The jury is out on the tolerability and safety of selective cyclooxygenase 2 (COX-2) inhibitors for treatment of rheumatological manifestations of inflammatory bowel disease (IBD), according to a new Cochrane review."
  October 2014 ,Medscape Medical News,Tiotropium Showing Promise in Pediatric Asthma,A drug and device combination already approved for COPD and effective in adults with asthma could provide an option for children with refractory disease.
  October 2014 ,Medscape Medical News,PV-10 in Metastatic Melanoma: Rapid Responses Led to Phase 3,"The product is injected directly into cutaneous melanoma lesions, but also improves noninjected lesions by an immunologic effect."
  October 2014 ,Medscape Medical News,Japanese Mushroom Extract Could Help Treat HPV Infections,"A mushroom extract eradicated persistent HPV infection in a small pilot study, and a larger phase 2 trial is now getting underway."
  October 2014 ,Medscape Medical News,Diet Therapy Effective in Adults With Refractory Epilepsy,"A ketogenic or modified Atkins diet should be considered in adults with refractory epilepsy, a new review suggests. "
  October 2014 ,News Alerts,"With Resurgence in Polymyxin Use, CHMP Revises Label ","As the rise in antimicrobial resistance has led to an increase in use of the half-century-old drug class, polymyxins, CHMP has recommended label revisions based on limited pharmacokinetic data. "
  October 2014 ,Medscape Medical News,Metformin Neglected as First-Line Therapy for Diabetes,"While widely recommended as first-line therapy for type 2 diabetes, metformin is being neglected as an initial treatment for many, despite new data     suggesting it's a good choice."
  October 2014 ,Medscape Medical News,TARGET 3: Rifaximin Safe to Reuse for Irritable Bowel,"Retreatment with rifaximin is safe and effective, report TARGET investigators. And long-term use of linaclotide is well tolerated."
  October 2014 ,Medscape Medical News,Ibuprofen Better Option for Kids With Fracture ,"For uncomplicated pediatric fracture, ibuprofen and morphine control pain equally, but ibuprofen causes fewer adverse effects."
  October 2014 ,Medscape Medical News,"EU CHMP Completes Review of Ponatinib, Finalizes Warnings",The European Committee for Medicinal Products for Human Use has now recommended strengthening its warning for ponatinib.
  October 2014 ,Medscape Medical News,Long-Acting Anesthetic Effect Achieved With Neosaxitoxins,"The novel site 1 sodium channel blocker, which belongs to the class of paralytic shellfish toxins, significantly prolonged time to partial and complete recovery."
  October 2014 ,Medscape Medical News,Initial Data on 'Pharma Grade' Cannabidiol in Epilepsy ,New data suggest that extracts of marijuana are effective for treatment-resistant epilepsy but may not be the 'miracle cure' some reports have suggested. 
  October 2014 ,Medscape Medical News,No Long-Term MS Risk After Vaccination,"A new study finds no association with multiple sclerosis up to 3 years following vaccination, but it did uncover a risk for demyelinating syndromes in patients under age 50 in the first few weeks after being vaccinated."
  October 2014 ,Medscape Medical News,Anti-inflammatories May Help Ease Depression,Results of a new meta-analysis provide preliminary support for using anti-inflammatories as an adjunctive treatment for depression.
  October 2014 ,Medscape Medical News,FDA Adds Everolimus to Watch List,Signal for possible hypertension risk leads FDA to add kidney cancer drug everolimus to watch list.
  October 2014 ,Medscape Medical News,Serious Impulse Control Disorders With Dopamine Agonists,"Researchers 'confirm and extend' evidence for the link between serious impulse control disorders, such as compulsive shopping and gambling and hypersexuality, and all 6 dopamine agonists used to treat Parkinson's disease."
  October 2014 ,Medscape Medical News,"Antidepressants Blunt Sexual Function, Feelings of Love",Long-term antidepressant use is associated with significant 'emotional blunting' manifesting as sexual dysfunction in women and impaired feelings of love in men.
  October 2014 ,Medscape Medical News,Cure Rates Remain High With Fecal Transplant for C difficile,"High and sustained cure rates continue to be reported after fecal microbiota transplant for patients with recurrent, refractory C difficile, with a few exceptions."
  November 2014 ,Medscape Medical News,"Amoxicillin Adverse Effects Underreported, Underrecognized","Data on adverse events are missing from many clinical trial publications, according to a new systematic review."
  November 2014 ,Medscape Medical News,Lupus Nephritis: Multidrug Induction Ups Complete Responses  ,"A combination of tacrolimus, mycophenolate mofetil, and steroid resulted in higher remission rates than cyclophosphamide plus steroid."
  November 2014 ,Reuters Health Information,"Botox, Fillers or Laser Treatments May Have Few Complications",Side effects or complications were rare and usually temporary in a U.S. study of noninvasive or minimally-invasive cosmetic procedures.
  November 2014 ,Medscape Medical News,Bexxar for Lymphoma: Gone but Not Forgotten,"The radiolabeled monoclonal antibody was withdrawn from the market more than a year ago, but a few have not forgotten its value in advanced lymphoma, and there's hope for a comeback in generic form."
  November 2014 ,Medscape Medical News,No Clear Winner for Relief of Diabetic Neuropathy Pain ,Which is the best drug for painful diabetic neuropathy? A new systematic review has generated some interesting observations.
  November 2014 ,Heartwire from Medscape,'Inactivating' NPC1L1 Mutations Protect Against CHD,"Mutations in a gene for the same protein targeted by ezetimibe may protect against CHD, a finding that comes less than a week before the world learns how ezetimibe performed in the IMPROVE-IT study."
  November 2014 ,Reuters Health Information,Amgen Psoriasis Drug Brodalumab Tops J and J's Ustekinumab,"Amgen Inc said on Tuesday that its experimental psoriasis drug, brodalumab, met all the goals of a late-stage study, clearing the rough skin patches associated with the disease more thoroughly than Johnson & Johnson's (ustekinumab) Stelara and a placebo."
  November 2014 ,Medscape Medical News,Immunotherapy for Metastatic Cancer Linked to Thyroid Disease,Novel therapies for the treatment of metastatic malignancies show effects on thyroid function; closer monitoring of patients at risk is urged.
  November 2014 ,Medscape Medical News,Symptom Severity May Predict Antipsychotic Efficacy,"Toward the mildest end of the spectrum, patients benefit less in terms of symptom improvement yet still experience the adverse effects of antipsychotics."
  November 2014 ,Medscape Medical News,Lorcaserin and Phentermine Safe Combo in Weight-Loss Trial,"A new pilot study examines the effect of adding a new weight-loss drug, lorcaserin, to an old appetite suppressant, phentermine."
  November 2014 ,Reuters Health Information,"Cognitive Therapy, Mindfulness for Menopausal Depression","Psychotherapy and mindfulness techniques could help many women who experience depression during menopause, according to a review of existing research."
  November 2014 ,Medscape Medical News,Arthritis Affects One Quarter of US Veterans: CDC,"A CDC analysis of survey data from 2011 to 2013 showed that 25.6% of veterans had arthritis, with higher prevalence among veterans than nonveterans across most sociodemographic categories. "
  November 2014 ,Medscape Medical News,FDA Panel Falls Short of Recommending Panobinostat,An FDA advisory panel voted 5 to 2 against recommending approval of panobinostat for treating multiple myeloma.
  November 2014 ,Medscape Medical News,Marijuana for Pediatric Seizures?  ,"As new studies get under way, child neurologists hope to provide children with epilepsy and their anxious parents more solid information about who might benefit from medical marijuana."
  November 2014 ,Medscape Medical News,Evidence Mounting for Eliglustat in Gaucher's Disease,"Eliglustat can treat type 1 Gaucher's disease almost as effectively as enzyme replacement therapy, new research shows."
  November 2014 ,Medscape Medical News,High BPA Levels in Men Reduces IVF Pregnancy Rates,"In men, exposure to bisphenol A (BPA) has a negative effect on in vitro fertilization (IVF) rates, according to the results of a new study."
  November 2014 ,Medscape Medical News,New WHO Guidelines Recommend Expanded Access to Naloxone,New guidelines recommending expanded access to the drug naloxone to reduce the number of opioid-related deaths globally have been released by the World Health Organization.
  November 2014 ,Medscape Medical News,"Cancer Researcher to Pay USD 475,000 to US to End Fraud Lawsuit","An expert in adverse drug effects, especially in patients with cancer, was accused of filing false expense claims against large grants from the National Institutes of Health."
  November 2014 ,Medscape Medical News,Adding CSF to Ipilimumab Improves Survival in Melanoma,Adding the granulocyte macrophage colony stimulating factor (GM-CSF) sargramostim to the immunological improved both survival and toxicity.
  November 2014 ,Medscape Medical News,POEM: Avoid Methimazole for Graves' Disease in Early Pregnancy,"Incidence of methimazole embryopathy is high, but treatment alternatives have risks of their own."
  December 2014 ,Medscape Medical News,Top-Five Tests and Treatments to Avoid in Sleep Disorders  ,The American Academy of Sleep Medicine lists five tests and procedures physicians and patients should question in its 'Choosing Wisely' list.
  December 2014 ,Medscape Medical News,Generic Antiepileptics Equivalent to Brand-Name Drugs,FDA-funded bioequivalency studies demonstrate how brand and generic antiepileptic drugs are tightly tied pharmacokinetically.
  December 2014 ,Medscape Medical News,"Positive Results With Brivaracetam, Perampanel, in Epilepsy","Researchers are reporting positive phase 3 trials of two antiepileptic drugs, one of which "
  December 2014 ,Medscape Medical News,Pharmacist Phone Call Before Physician Visit Enhances Care,"Checking medication lists and discussing adherence problems saves time and money for primary care physicians and improves patient satisfaction, say researchers."
  December 2014 ,Medscape Medical News,"Novel Program Reduces Depressive Symptoms, Benzo Use","An 8-week, community-based depression recovery program decreases symptoms of moderate depression and, fortuitously, benzodiazepine use."
  December 2014 ,Medscape Medical News,PD-1 Blockade Arrives in Hematologic Cancer,Two programmed cell death 1 (PD-1) inhibitors have demonstrated efficacy in phase 1 studies of patients with relapsed or refractory Hodgkin lymphoma.
  December 2014 ,Medscape Medical News,Symptom Severity May Predict Antipsychotic Efficacy,"Toward the mildest end of the spectrum, patients benefit less in terms of symptom improvement, yet still experience the adverse effects of antipsychotics."
  December 2014 ,Medscape Medical News,EU Green Light for Liraglutide in Diabetes With Renal Disease," Drugs for type 2 diabetes that can be used without dose adjustment in patients who also have kidney disease are few and far between. But trials are being     conducted, and one new option has emerged."
  December 2014 ,FDA Approvals,First Drug for Polycythemia Vera Approved by FDA,"Ruxolitinib has become the first drug for polycythemia vera to be approved by the FDA; the drug is already marketed for use in myelofibrosis, another bone marrow disorder."
  December 2014 ,Heartwire from Medscape,Potassium-Binding Agent Relieves Hyperkalemia in Phase 3 Study," Agents that sequester potassium in the intestines are advancing in clinical trials; here, one with the active ingredient zirconium cyclosilicate seemed effective and safe acutely and over 1 month."
  December 2014 ,Medscape Medical News,New Study Refutes Pioglitazone and Bladder Cancer Link,"More data on the ongoing controversy regarding pioglitazone and bladder cancer, this time from a large research consortium that employed novel methods of     analyses."
  December 2014 ,Reuters Health Information,Skin Problems Common With Cabozantinib Cancer Therapy,"Cabozantinib monotherapy leads to skin problems in most patients with metastatic, progressive urothelial carcinoma, according to new research."
  December 2014 ,Medscape Medical News,Bisphosphonates Neglected in Men on Androgen Deprivation ,Most men prescribed androgen-deprivation therapy for prostate cancer are at increased risk for bone loss and fracture but are not receiving concomitant     prophylactic bisphosphonates.
  November 2014 ,Medscape Medical News,Long-Lasting Responses With Immunotherapy in Melanoma ,"An update on data from early clinical trials showed that patients are surviving for years on immunotherapy with nivolumab, ipilimumab, and a combination of the two. "
  November 2014 ,Reuters Health Information,MRIs May Be Too Painful With Cochlear Implants,"Magnetic resonance imaging (MRI) may displace the magnets of cochlear implants or cause extreme discomfort for some wearers, according to a new study."
  November 2014 ,News Alerts,FDA Warns of PML Risk With Tecfidera in MS,The has FDA announced that risk for PML will be added to the label after a fatal case in a patient taking dimethyl fumarate for 4 years.
  November 2014 ,International Approvals,"EMA Panel Backs Exviera, Viekirax for Chronic Hepatitis C",Exviera and Viekirax were recommended by the European Medicines Agency's Committee for Medicinal Products for Human Use for the treatment of adults with chronic hepatitis C. 
  November 2014 ,Medscape Medical News,"Surprising Result Shows Kidney, Mortality Benefits of Niacin","A large observational study, in contrast to two randomized controlled trials, shows that niacin administration reduces all-cause mortality and declines in kidney function."
  November 2014 ,FDA Approvals,FDA Clears Hydrocodone With Abuse-Deterrent Properties ,"The physical and chemical properties of single-entity Hysingla ER (Purdue Pharma) are expected to make abuse difficult, the FDA says. "
  November 2014 ,Medscape Medical News,Trans Fat Linked to Worse Memory  ,A new study finds an association between higher consumption of foods containing trans fats and reduced word memory in men of working age. 
  December 2014 ,Medscape Medical News,Juvenile Arthritis: Adverse Events Common With Biologics ,"Biologics were associated with serious events in 1 in 3 patients with JIA taking them, but treatment is rarely discontinued, according to a large study."
  December 2014 ,FDA Approvals,FDA Expands Use of Ivacaftor (Kalydeco) for Cystic Fibrosis,The agency has approved the CFTR potentiator for use in children aged 6 years and older with cystic fibrosis who have the R117H mutation. 
  December 2014 ,Medscape Medical News,More Than 50% of Antipsychotics Prescribed Off Label,"Antipsychotics are routinely prescribed for nonpsychotic diagnoses, particularly in women, older people, and the economically disadvantaged."
  December 2014 ,Medscape Medical News,Obese Women Have Unique Surgical Risks,"Gynecologic surgeons should be familiar with risks faced by obese women, such as surgical site infection, venous thromboembolism, and wound complications, to provide counsel before surgery."
  December 2014 ,Reuters Health Information,Biologic Combo Therapy Sometimes Needed for Psoriasis,"Biologic agents alone may not work in all patients with psoriasis and a combination approach may be needed, according to recommendations from the Medical Board of the National Psoriasis Foundation."
  December 2014 ,FDA Approvals,FDA Approves Nivolumab (Opdivo) for Advanced Melanoma,The FDA has granted a highly anticipated accelerated approval to the PD-1 inhibitor nivolumab for advanced melanoma.
  December 2014 ,FDA Approvals,FDA OKs Combination Antibacterial Zerbaxa,Zerbaxa combines ceftolozane and tazobactam and is indicated for treatment of complicated intra-abdominal and urinary tract infections.
  December 2014 ,Reuters Health Information,"Latanoprostene Bunod for Glaucoma, Ocular Hypertension","Latanoprostene bunod (LBN) 0.024% reduced intraocular pressure (IOP) more than latanoprost 0.005% (Xalatan, Pfizer), but with more side effects, in a study of patients with open angle glaucoma (OAG) or ocular hypertension (OHT)."
  December 2014 ,Medscape Medical News,To T3 or Not: Combo Therapy in Hypothyroidism,"The new ATA guidelines on hypothyroidism have sparked controversy, with endocrinologists reacting in different ways to the recommendations regarding     thyroid-hormone-replacement therapy."
  December 2014 ,Medscape Medical News,Benzodiazepine Use Highest in Older Americans,"Despite inherent risks and questionable efficacy, long-term use of the benzodiazepines increases steadily with age among US residents and is especially prevalent among older women."
  December 2014 ,Medscape Medical News,Nitrous Oxide Explored for Resistant Depression,A new proof-of-concept study suggests 'laughing gas' improves depression even after the drug's sedative effects wear off.
  December 2014 ,Medscape Medical News,"Low-Carb, High-Fat Diets Effective for Adult Epilepsy ","Variations of low-carbohydrate, high-fat dietary plans reduce seizures at a rate similar to that of antiepileptic drugs."
  December 2014 ,Medscape Medical News,ASH Unveils Second Choosing Wisely List,"As part of the Choosing Wisely initiative, the American Society of Hematology (ASH) has released five more tests and treatments that should be questioned."
  December 2014 ,Medscape Medical News,New Algorithm for Treatment of Premenopausal Breast Cancer,Results from the Suppression of Ovarian Function Trial (SOFT) are practice changing for a subgroup of premenopausal women with breast cancer.
  December 2014 ,Medscape Medical News,Tamoxifen Continues to Shine for Breast Cancer Prevention,"After a follow-up of as long as 22 years, tamoxifen continues to protect women with a familial or genetic increased risk from developing breast cancer, but the drug is still a hard sell for many clinicians."
  December 2014 ,Medscape Medical News,Pain Med Linked to Hypoglycemia ,"Tramadol, an opioid analgesic, was associated with an increased risk for hospitalization for hypoglycemia, especially in the first month of use, in a new study. "
  December 2014 ,Reuters Health Information,Minoxidil May Be Dangerous to Kids,"Minoxidil, best known as a hair-loss treatment, may cause dangerous side effects in kids who are accidentally exposed to it, say the authors of a recent case study from France."
  December 2014 ,News Alerts,Antipsychotic Linked to Potentially Fatal Skin Reaction,"An antipsychotic, along with its generic counterparts, used to treat schizophrenia and bipolar I disorder has been linked to a rare but potentially fatal skin reaction."
  December 2014 ,Medscape Medical News,Breast Cancer With High TIL Levels: Skip the Trastuzumab?,A provocative study suggests that HER2 breast cancer patients with high levels of stromal tumor infiltrating lymphocytes may not need trastuzumab (Herceptin).
  December 2014 ,Medscape Medical News,New Deadly Class of Synthetic Hallucinogens Mimics LSD,"NBOMe, a novel class of synthetic hallucinogens, which is being sold as a cheaper and more readily available substitute for LSD, is emerging as a particularly lethal drug."
  February 2015 ,Medscape Medical News,FDA Commissioner Dr Margaret Hamburg to Step Down,Dr Hamburg is credited with advocating for safe drugs and devices while partnering with industry. Will Rob Califf take her place?
  January 2015 ,FDA Approvals,US FDA Approves Natpara for Hypoparathyroidism ," After an additional 3 months to consider its decision, the US FDA has finally ruled on a recombinant parathyroid hormone product, Natpara, to control     hypocalcemia in patients with hypoparathyroidism."
  January 2015 ,Reuters Health Information,Aflibercept Might Be Tied to Intraocular Inflammation,"Sterile ocular inflammation following injection of aflibercept (Eylea, Regeneron Pharmaceuticals) outlined in post-marketing reports should prompt further investigation, according to researchers."
  January 2015 ,International Approvals,Two Ophthalmic Drugs Receive Positive Nods in Europe,The European Committee for Medicinal Products has recommended approval of ciclosporin drops for severe keratitis and a new indication for aflibercept.
  January 2015 ,International Approvals,CHMP Says Yes to Two Antibiotics for Skin Infections,Oritavancin (Orbactiv) and tedizolid phosphate (Sivextro) have received positive opinions from the EMA committee for acute bacterial skin and skin structure infections.
  January 2015 ,Medscape Medical News,Seniors Commonly Mix Alcohol With Meds,"Although many US adults of all ages put themselves at risk by mixing drugs and alcohol, this dangerous practice is especially prevalent in the elderly."
  January 2015 ,Medscape Medical News,New AHS Review of Acute Migraine Treatments,"The assessment, which will form the basis of new US clinical practice guidelines, represents the first update to treatment recommendations in 15 years. "
  January 2015 ,Medscape Medical News,Oxytocin May Help Frontotemporal Dementia,Intranasal oxytocin given twice daily for 1 week showed preliminary signs of improvement in apathy and loss of empathy in patients with frontotemporal dementia. 
  January 2015 ,Medscape Medical News,Clinical Cancer Advances in 2014: CLL Is the Winner,"This year in its annual review of clinical cancer advances, the American Society of Clinical Oncology has, for the first time, announced a winner."
  January 2015 ,Medscape Medical News,Tapentadol Toxicity in Children,"Most pediatric patients exposed to this novel analgesic (Nucynta) had no major effects, but there were 2 cases with life-threatening events, poison center reports show."
  January 2015 ,Medscape Medical News,Biomarker May Predict Best Smoking Cessation Treatment,A genetic biomarker may help predict response to specific smoking cessation treatments.
  January 2015 ,Medscape Medical News,"PRAC Concludes Safety Review of Ambroxol, Bromhexine Meds",The review prompted the EMA committee to recommend updating the product information on ambroxol- and bromhexine-containing medicines to include a small risk for severe allergic reactions. 
  January 2015 ,Medscape Medical News,Expert Panel Final Report on Opioids in Chronic Pain,An independent expert panel convened by NIH has published a final report identifying knowledge gaps and calling for more research into various aspects of chronic pain management and long-term opioid use.
  January 2015 ,Medscape Medical News,"Long-Acting Contraceptives Safe and Effective, Yet Underused","The levonorgestrel intrauterine system and etonogestrel subdermal implants are well-tolerated and associated with few serious adverse effects, and 88% of teenagers used them for at least 12 months."
  January 2015 ,Medscape Medical News,"Metformin Label Too Restrictive on Renal Grounds, Limits Use","Has the US label contraindicating metformin use in type 2 diabetes patients with mild renal insufficiency led to underuse of the drug? A new study suggests     this is the case, and others agree."
  January 2015 ,Medscape Medical News,New Type of Antibiotic May Be Less Prone to Resistance ,"A novel antimicrobial compound effectively kills gram-positive bacteria, but showed no evidence of resistance in animal tests. "
  January 2015 ,Medscape Medical News,Positive Topline Phase 2 Results for Novel Schizophrenia Drug,A novel oral antipsychotic proves as effective as olanzapine with less weight gain in patients with schizophrenia.
  January 2015 ,Medscape Medical News,Does 'War on Cancer' Metaphor Cause Casualties?,"The metaphor of waging a war against cancer could have unintended consequences, such as hampering prevention and leaving patients who progress feeling defeated."
  January 2015 ,Medscape Medical News,"MMRV Vaccine Safe, With Rare Adverse Effects ",Several of the evaluated adverse outcomes occurred rarely to not at all after vaccination with either MMR + V or the newer MMRV. 
  January 2015 ,Medscape Medical News,"Marijuana Promising in Rare Epilepsies, But It's Still Early","New data are encouraging, but researchers remain restrained in their assessments, saying randomized, controlled trials are sorely needed."
  February 2015 ,Medscape Medical News,Gene Variant Linked to Increased Toxicity of Vincristine,A previously unknown gene variant has been linked to increased risk and severity of vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia.
  February 2015 ,FDA Approvals,FDA Approves Panobinostat for Relapsed Multiple Myeloma,"The first-in-class agent has been granted accelerated approval, despite having been voted down by the advisory committee late last year."
  February 2015 ,Medscape Medical News,Oncologists Need to Ask About Herbs and Supplements,"A new survey shows that only 26% of US oncologists ever initiate discussions about the use of herbs and other supplements, even though they are widely used."
  February 2015 ,Medscape Medical News,Radiation Used in Too Many Men With Indolent Prostate Cancer,"American men with low-risk prostate cancer are being overtreated, primarily with radiation therapy, a population-based study has shown."
  February 2015 ,News Alerts,First Proton Therapy Device Cleared in Canada,"Canada has cleared the way for the use of proton therapy in cancer patients, which offers an alternative to the conventional photon radiotherapy."
  February 2015 ,Medscape Medical News,Long-Acting Opioids Related to Unintentional Overdose Risk,"Patients receiving long-acting opioids were 2.3 times more likely to experience an unintentional overdose overall, and 5 times more likely in the first 2 weeks of treatment. "
  February 2015 ,Reuters Health Information,Case Report: Fecal Transplants May up Risk of Obesity Onset,"Fecal microbiota transplantation can be effective for recurrent Clostridium difficile infection, but new-onset obesity could follow transplant of stool from an overweight donor, say the authors of a case report."
  February 2015 ,Medscape Medical News,Endocrine Societies at Odds Over Advice on T3 for Hypothyroidism,The American Thyroid Association and American Association for Clinical Endocrinology may have to agree to disagree on whether or not to endorse use of     triiodothyronine in hypothyroid.
  February 2015 ,News Alerts,"Limit Hydroxyzine to Reduce Cardiac Risks, EU Regulators Say ","Clinicians should prescribe the lowest effective dose for the shortest period possible to reduce the risk for potentially fatal heart arrhythmias, an EMA committee has recommended."
  February 2015 ,Reuters Health Information,A Dissolving Film Could Replace Eye Drops for Ocular Drug Delivery,"A dissolving film in development now may someday prove more effective than eye drops in treating eye conditions, new data from mouse trials suggests."
  February 2015 ,Kaiser Health News,Some Pediatricians Don't Have Adequate Training With IUDs,"When Wendy Sue Swanson started out as a pediatrician eight years ago, it never crossed her mind to bring up the option of intrauterine devices."
  February 2015 ,Reuters Health Information,New Wave of Drugs Poised to Shake up Glaucoma Treatment,"For the first time in 20 years, patients suffering from the eye disease glaucoma may soon have new treatments as several young companies look to shake up the $5.6 billion global market"
  February 2015 ,Medscape Medical News,Latest Roche-Sponsored Tamiflu Review Enters the Fray ,"A meta-analysis of individual patient data from nine randomized controlled trials showed reduced symptom duration and more adverse effects, but outside experts call 'foul' -- again. "
  February 2015 ,Medscape Medical News,Axitinib Shown to Be Active in Resistant CML and B-ALL,"Axitinib, a VEGFR inhibitor used in the treatment of kidney cancer, has surprisingly now shown activity in certain hematologic malignancies."
  February 2015 ,FDA Approvals,FDA Clears Ranibizumab for Diabetic Retinopathy With DME,Ranibizumab for diabetic retinopathy with DME had breakthrough therapy designation and was reviewed under the agency's priority review program.
  February 2015 ,Medscape Medical News,"Dogs Give Love, Improve Outcomes in Cancer Study",Man's best friend is a friend even in the worst of times.
  February 2015 ,Medscape Medical News,Modern Birth Control Could Prevent 15M Unwanted Pregnancies,Optimal use of modern contraceptives could avert an estimated 15 million of 16.7 million unwanted pregnancies each year in 35 low- and middle-income countries.
  February 2015 ,Medscape Medical News,One in 12 Pediatric Emergency Visits Related to Medications,Medication-related issues were to blame for 1 in 12 pediatric visits to the emergency department in a recent study; 65% of the visits were potentially preventable.
  February 2015 ,Medscape Medical News,Diquafosol Beats Hyaluronate in Treating Dry Eyes,Diquafosol helped patients with dry eye resulting from mucin deficiency more than hyaluronate. 
  February 2015 ,Medscape Medical News,"Patient Voices Essential, as Docs Underreport Toxicities",The voices of cancer patients are essential when it comes to reporting toxic effects in clinical trials because physicians tend to under-report.
  March 2015 ,Heartwire from Medscape,Anacetrapib Provides Large LDL-Lowering Benefit in FH,"Anacetrapib allowed significantly more FH patients to attain their LDL-cholesterol treatment goals, but researchers are urging caution with the agent     because two others in the class have failed in large clinical-outcomes trials."
  March 2015 ,Reuters Health Information,Vulvovaginal Atrophy Symptoms Improve With Prasterone Treatment,"Prasterone treatment has parallel beneficial effects on the three main symptoms of vulvovaginal atrophy (VVA), regardless of which symptom a patient finds the most troubling, a new phase III open-label study shows."
  March 2015 ,Medscape Medical News,Hepatitis E Vaccine Effective and Long Lasting ,"The hepatitis E vaccine was effective, and the protection it provided lasted for up to 4.5 years after vaccination, a long-term study showed."
  March 2015 ,Medscape Medical News,ED Docs Well Placed to Give Positive Info About Vaccination,Emergency physicians are in a position to screen children for vaccinations and counter misconceptions about vaccine safety by delivering the facts in a nonjudgmental way.
  March 2015 ,Medscape Medical News,Stimulant May Speed Antidepressant Response Time in Elderly,Methylphenidate combined with the antidepressant citalopram significantly reduced time to depression remission in elderly patients.
  March 2015 ,News Alerts,"FDA Approves Nivolumab, First Immunotherapy for Lung Cancer","Approved 3 months ahead of schedule, nivolumab is the first immunotherapy to have shown a survival benefit in non-small cell lung cancer."
  March 2015 ,Medscape Medical News,New Data Suggest Water Fluoridation Linked to Hypothyroidism,A populationwide study suggests a link between fluoride levels in drinking water and hypothyroidism in England. Hypothyroidism was nearly twice as likely     in fluoridated areas as nonfluoridated.
  March 2015 ,Medscape Medical News,Canadians Crystallize Obesity Advice: Action Beats Inaction,Five review articles highlight the value of obesity prevention and treatment programs for children and the benefits of modest weight loss and prevention of     weight regain in overweight and obese adults.
  March 2015 ,Medscape Medical News,GAO Report Cites Antipsychotic Overuse in Dementia Patients,The agency urged the federal government to do more to reduce use of pharmacologic therapies; CMS has set goal to reduce prescribing in nursing homes by about half by 2016. 
  March 2015 ,News Alerts,"Testosterone Labels Must Now Note CV, Stroke Risks, FDA Says",The FDA will require testosterone-replacement products to clarify approved uses and cite the risk for heart attack and stroke.
  March 2015 ,Medscape Medical News,"ACP Updates Guidelines on Bedsore Prevention, Treatment ","The recommendations include advanced static mattresses, protein or amino acid supplements to reduce wound size, and electrical stimulation."
  March 2015 ,Medscape Medical News,Acetaminophen Risks May Have Been Underestimated,"Acetaminophen (paracetamol) may have more risks than originally thought, but an independent expert, and even the study author, say the new data should be taken with a grain of salt."
  March 2015 ,Medscape Medical News,Novel Combination 'Encouraging' in Advanced Kidney Cancer,An investigational antiangiogenic inhibitor of the ALK1 pathway and a VEGF inhibitor showed promising activity and a good safety profile in advanced renal cell carcinoma.
  March 2015 ,Medscape Medical News,Childhood Vaccines: Parents Often Ask Docs to Spread Them Out ,Physicians need strategies to increase the timeliness and completeness of vaccinations. 
  February 2015 ,Medscape Medical News,The Opioid-Free ED: Coming Soon to a Hospital Near You,"The emergency department (ED) can sometimes be the birthplace of opioid addiction, which is reason enough to find alternative effective nonopioid analgesics."
  February 2015 ,Reuters Health Information,Combination Therapy Helpful in Refractory Alopecia,"Combination therapy with diphenylcyclopropenone (DPCP) and anthralin is more effective than DPCP alone in patients with chronic extensive alopecia areata (AA), according to Turkish researchers."
  February 2015 ,Medscape Medical News,"Preconception Bariatric Surgery May Cut Risks for Mom, Fetus  ","Obese women who undergo bariatric surgery before pregnancy have reduced risk for gestational diabetes and large-for-gestational-age infants, but risk for other adverse effects may be increased."
  February 2015 ,Medscape Medical News,Sublingual Immunotherapy Safe Alternative for Peanut Allergy,"Long-term sublingual immunotherapy for peanut allergy can provide a lasting benefit in some children, although the effect is not as strong as with oral options."
  February 2015 ,Medscape Medical News,Insulinlike Growth Factor Promising for Rare Autism Type,A small pilot study suggests insulinlike growth factor holds promise for the rare Phelan-McDermid syndrome and may have treatment implications for other autism spectrum disorders.
  February 2015 ,Medscape Medical News,Defibrotide Significantly Boosts Survival in VOD,Defibrotide significantly improved outcomes across all subgroups of patients who developed veno-occlusive disease after stem cell transplant.
  March 2015 ,Medscape Medical News,Aspirin Protection for Colorectal Cancer Depends on Genetics,The reduced risk for colorectal cancer risk seen in people taking aspirin or related NSAIDs appears to be linked to genetic variations in two common SNPs.
  March 2015 ,Medscape Medical News,Antipsychotic Metabolic Screening in Kids Abysmal,"More than a decade after metabolic screening recommendations for children starting atypical antipsychotics were introduced, rates are nearly as low as they were at baseline."
  March 2015 ,Medscape Medical News,Ultrasound Accurate for Diagnosing Pneumonia in Children,"Lung ultrasounds may be a viable alternative to chest radiographs, especially in places with limited resources, a metaanalysis suggests."
  March 2015 ,Medscape Medical News,"HCV Drugs Cost-effective, but Who Should Get Them?","Should new drugs, which can cost $1000 per pill, be rationed by genotype, disease stage, age, or whether patients reinfect themselves? Or will drug companies eventually reduce costs? "
  March 2015 ,Medscape Medical News,"More Studies Support Testosterone CV Safety, Debate Continues","Two new analyses suggest that there is no increased risk for venous thromboembolism or cardiovascular events with testosterone treatment, but experts say     the definitive trial has yet to be done."
  March 2015 ,Medscape Medical News,Oncotype DX: Usage Consistent With Guidelines,New data show that the 21-gene recurrence score for predicting risk for metastatic breast cancer has been quickly adopted in clinical practice.
  March 2015 ,News Alerts,EU Advisory Body Aims to Reduce Bone Drug Osteonecrosis Risk ,"The European Medicines Agency's pharmacovigilance panel advises new product labeling and patient reminders about the osteonecrosis risk with zoledronic acid, with future plans to target other bone drugs. "
  March 2015 ,Reuters Health Information,Chikungunya Vaccine Trial Shows Promise,"A live recombinant vaccine against chikungunya infection, produced by modifying the measles vaccine virus, was safe and induced a good immune response in healthy volunteers in a new study from Austria."
  March 2015 ,News Alerts,EMA Panel Recommends Codeine Restriction for Cough in Kids,"A committee of the European Medicines Agency has recommended restricting the use of codeine for cough and cold in children because it can cause serious adverse effects, including breathing problems."
  March 2015 ,State Health Alerts,"Multi-State Measles Outbreak & Influenza Update, March 2015",A multi-state outbreak of measles is ongoing; clinicians should ensure their patients are appropriately vaccinated. Influenza activity is still widespread in New Hampshire; initial symptoms of influenza and measles can be similar.
  March 2015 ,Heartwire from Medscape,Genetic Sensitivity to Warfarin Linked with Bleeding ,   The analysis from ENGAGE AF-TIMI 48 links variants in two genes known to alter the pharmacokinetics and pharmacodynamics of warfarin with bleeding-events rates.
  March 2015 ,FDA Approvals,FDA Okays Saphris for Pediatric Bipolar Disorder,The FDA has approved another atypical antipsychotic for the treatment of pediatric patients with bipolar 1 disorder.
  March 2015 ,Medscape Medical News,Heart Failure Not Increased With Diabetes Drug Alogliptin? ," A new analysis of EXAMINE finds no significant overall increase in heart-failure end points with alogliptin, but the jury is still out on this potential     risk with DPP-4 inhibitors, say editorialists."
  March 2015 ,Medscape Medical News,"SSRIs Safe, Tolerable for Pediatric Anxiety",An exhaustive analysis of adverse events associated with the treatment of anxiety in children and adolescents in the CAMS study concludes that the use of SSRIs is safe in this population.
  March 2015 ,FDA Approvals,First Therapy for High-Risk Neuroblastoma Approved by FDA,"Dinutuximab, an antibody targeting glycolipids on the neuroblastoma cell, used in combination with other therapies has been shown to improve survival."
  March 2015 ,News Alerts,"Chantix May Lower Alcohol Tolerance, Up Seizure Risk: FDA",The FDA has changed the labeling on the smoking cessation medication Chantix to reflect concerns that the drug may lower alcohol tolerance and boost seizure risk.
  March 2015 ,Heartwire from Medscape,"Antidepressants, Statins Have Separate Impact on CV Mortality","Nondepressed outpatients benefited from statins, and depressed outpatients benefitted from antidepressants; the two therapies were not synergistic, in a     study of 3-year CV outcomes."
  March 2015 ,Medscape Medical News,Endocrine Disruptors Cause Range of Diseases; Cost 157 Billion Euros,"A new EU analysis suggests a wide range of neurologic, endocrinologic, and reproductive abnormalities from chemicals used in everyday products such as     pesticides, cosmetics, and flame retardants."
  March 2015 ,Medscape Medical News,Websites Marketing Genetic Cancer Tests Oversell Benefits,"Websites marketing personalized cancer care services often overemphasize benefits and downplay limitations, and offer genetic tests of questionable value."
  March 2015 ,Medscape Medical News,Image-Guided Lidocaine Injections for Headache ,"Lidocaine injections into part of the trigeminal nerve near the brain under fluoroscopic guidance improved migraine and cluster headaches, a new study shows."
  March 2015 ,News Alerts,NEPA Combo for CINV Nears Approval in Europe,"In Europe, approval has been recommended for combination netupitant and palonosetron to prevent chemotherapy-induced nausea and vomiting (CINV) in cancer patients."
  March 2015 ,Heartwire from Medscape,Trial Has Lessons for Search for 'the Perfect Anticoagulant',"Allergic reactions cut short a major trial of the REG1 anticoagulant-antidote drug pairing, but researchers seem undeterred in their search for a safer, controllable anticoagulant for use in PCI. "
  March 2015 ,Medscape Medical News,Biologics Take Aim at Psoriasis Despite Worry Over Reactions,"The oral drug tofacitinib, typically prescribed for rheumatoid arthritis, is showing promise for the treatment of psoriasis, and new experimental agents are gaining ground."
  March 2015 ,Medscape Medical News,Gadolinium Found in Brain Tissue,"Researchers found traces of gadolinium among deceased persons, most commonly in the dentate nuclei, in amounts related to the number of contrast-enhanced MRI examinations they received. "
  March 2015 ,Medscape Medical News,Antipsychotic Death Risk Revised Upwards in Dementia Patients,Antipsychotics used to treat dementia patients carry a greater mortality risk than previous research suggests.
  March 2015 ,Medscape Medical News,Budesonide Has Potential for Lung Cancer Chemoprevention,"Inhaled budesonide significantly decreased the size of nonsolid lung nodules, which is of potential importance because some can progress to adenocarcinoma."
  March 2015 ,Heartwire from Medscape,K-Binder Patiromer Could Keep Patients on HF RAAS Inhibitors ,"A new breed of potassium-binding agents could herald ""a new era for renal disease and heart failure that really will change the game,"" says a prominent researcher. Others express caution about them."
  March 2015 ,Medscape Medical News,Is Bevacizumab Truly a New Standard in Cervical Cancer?,"New data on quality of life show 'convincingly' that it is not adversely affected, but does it all add up to a new standard?"
  March 2015 ,Heartwire from Medscape,EAS Offers Advice on Statin-Induced Muscle Pain,"The EAS stresses that statins are the first, second, and third treatment course in patients with muscle pain, and all efforts should be made to get the     patient back on the lipid-lowering medication."
  March 2015 ,Medscape Medical News,Cold Therapy Freezes Forehead Wrinkles,"The new approach uses cold thermal injury to block motor nerves and trigger temporary muscle relaxation, leading to fewer facial wrinkles."
  March 2015 ,Heartwire from Medscape,Alirocumab Effective Against LDL-C Top of Max-Dose Statin,"  Statins increase plasma concentrations of PCSK9, the target of alirocumab, but an analysis suggests high-dose statin therapy won't interfere with the PCSK9     inhibitor's benefit."
  March 2015 ,Medscape Medical News,GPs Should Focus on Individualizing Diabetes Treatment ,"  In a commentary on the recent American Diabetes Association's Standards of Care, authors point to individualization and patient-centeredness as key     concepts for primary-care clinicians."
  March 2015 ,Medscape Medical News,Cosyntropin Shows Efficacy for Postdural Puncture Headache," The gold standard treatment, epidural blood patch, isn't always effective, and an alternative could be beneficial when there are contraindications."
  March 2015 ,Medscape Medical News,Antiviral Promising in Early HPV Trial,The experimental drug ranpirnase has the potential to be the first antiviral treatment for human papillomavirus (HPV).
  March 2015 ,Medscape Medical News,"Transperineal Prostate Biopsy 'Well Tolerated,' Study Shows",The newer technique of transperineal biopsy performed under general anesthetic produced scores similar to those obtained with the standard transrectal approach.
  March 2015 ,Reuters Health Information,Phase 3 Results Positive for Prasterone for Menopause-Related Pain,"Daily use of an experimental treatment, prasterone, may ease pain from vaginal intercourse in postmenopausal women, according to a study sponsored by the maker of prasterone, EndoCeutics."
  March 2015 ,Medscape Medical News,Phenylephrine Eyedrops Safe for Routine Clinical Use,"Phenylephrine 2.5% eyedrops are safe for routine clinical use, according to a systematic review and metaanalysis; transient increases in blood pressure and heart rate occurred with phenylephrine 10%."
  March 2015 ,Medscape Medical News,FDA Panel Backs Breo Ellipta for Asthma in Adults,"The panel recommended against approving the long-acting beta-agonist combination therapy for children, primarily due to safety concerns."
  March 2015 ,Medscape Medical News,"In Hodgkin's Lymphoma, Brentuximab vs Placebo for First Time",Brentuximab vedotin given early after stem cell transplant in patients with hard-to-treat Hodgkin's lymphoma improved progression-free survival compared with placebo.
  March 2015 ,FDA Approvals,FDA OKs Ivacaftor (Kalydeco) for Preschoolers With CF,Ivacaftor is now indicated in the US for children aged as young as two years with CF and one of 10 mutations in the CFTR gene; a new formulation can be mixed with soft foods or liquids.
  April 2015 ,Medscape Medical News,Precision Medicine Needs 'Precision Genomics',"In half of all cancer patients, tumor-only gene sequencing is not enough to guide therapeutic decisions on the use of precision cancer agents."
  April 2015 ,Reuters Health Information,More Intussusception Hospitalizations in California After Rotavirus Vaccine Intro,"The risk of intussusception hospitalizations in infants in California has risen since the introduction of rotavirus vaccines in 2006 and 2008, according to researchers."
  April 2015 ,Reuters Health Information,U.S. Prescription Drug Spending Rose 13 Percent in 2014: IMS Report,"Long-term lithium therapy has been linked to thyroid dysfunction, but only in women."
  April 2015 ,Medscape Medical News,"Lithium Linked to Thyroid Dysfunction, but Only in Women","The anticonvulsant topiramate, which is approved to treat pediatric epilepsy, migraine, and migraine prevention, may trigger or exacerbate eating disorders in young at-risk patients."
  April 2015 ,Medscape Medical News,"Anticonvulsant May Trigger, Exacerbate Eating Disorders","Doctors treating patients with fumaric esters for MS or psoriasis should be alert for PML both in lymphopenic and in nonlymphopenic patients, researchers say. "
  April 2015 ,Medscape Medical News,First Case of Fumarate-Linked PML in Nonlymphopenic Patient,An extended phase 3 study confirmed that up to six successive once-yearly implants that release histrelin may be a viable option to stop the progression of     central precocious puberty.
  April 2015 ,Medscape Medical News,Histrelin for Precocious Puberty Effective in 6-Year Study,"With the first biosimilar approved by the US Food and Drug Administration, and more on the horizon, prescribers are going to need to brush up on the complexities of these products."
  April 2015 ,Medscape Medical News,Biosimilar Approvals Prompt Drug Swap Difficulties,"Pooled data do not prove the safety of finasteride for androgenic alopecia (AGA), with sexual side effects in particular not adequately evaluated, according to a new meta-analysis."
  April 2015 ,Reuters Health Information,Finasteride Safety Questionable in Androgenic Alopecia,"A novel, potent mu-opioid antagonist with olanzapine is designed to attenuate olanzapine-induced metabolic side effects. "
  April 2015 ,Medscape Medical News,Novel Schizophrenia Drug Continues to Show Promise,"Both metformin and glyburide are effective oral agents for maintaining glycemic control in gestational diabetes mellitus (GDM). However, certain side effects are greater with glyburide, according to Chinese researchers."
  April 2015 ,Reuters Health Information,Metformin May Edge Glyburide in Gestational Diabetes,Antidepressants administered in therapeutic doses to depressed patients have been linked to an increased risk for first-time seizures.
  April 2015 ,Medscape Medical News,Antidepressants at Normal Doses Linked to First-Time Seizures,"The long-term formulation of paliperidone, which is currently under FDA review, may be the first atypical antipsychotic administered on a four-times-a-year dosing schedule."
  April 2015 ,Medscape Medical News,Long-term Injectable Antipsychotic Cuts Schizophrenia Relapse,"The first-in-class drug, in addition to showing improvement in schizophrenia symptoms, shows signs of improving depression and social function."
  April 2015 ,Medscape Medical News,Novel Drug Promising for Schizophrenia,"Even with long-term evidence of the superiority of intraperitoneal (IP) over intravenous (IV) chemotherapy for advanced ovarian cancer, controversy lingers."
  April 2015 ,Medscape Medical News,Controversial IP Route Trumps IV Chemo for Ovarian Cancer,"As healthcare providers become increasingly pressured to provide quality care, the American Academy of Sleep Medicine has developed quality measures for the five most common sleep disorders."
  March 2015 ,Medscape Medical News,New AASM Quality Measures for Common Sleep Disorders,The anemia drug will now carry a boxed warning on the potential for life-threatening allergic reactions.
  March 2015 ,News Alerts,FDA Orders Stricter Warnings for Ferumoxytol (Feraheme),"The effect was so powerful that the Data Safety and Monitoring Board stopped the trial, report researchers."
  March 2015 ,Medscape Medical News,Naproxen Lowers Ossification Risk in Hip Arthroscopy,"A benzodiazepine or an SSRI successfully treats panic disorder, but nearly all patients relapse, even after years of treatment, once drug is withdrawn. Reinstating drugs can get the disorder under control."
  March 2015 ,Medscape Medical News,"Drug Therapy Prevents Panic Attacks, but Relapse Very Common","Intra-articular ketorolac shows efficacy similar to that of corticosteroid injections in the treatment of knee osteoarthritis, a new study shows."
  May 2015 ,Medscape Medical News,Mindfulness Therapy May Offer Alternative to Antidepressants,Mindfulness-based cognitive therapy may offer an alternative to drug treatment for recurrent depression.
  May 2015 ,Medscape Medical News,Laser Treatment Halts Oral Mucositis in Its Tracks,Six minutes of treatment with the same type of laser that is used to treat wrinkles can prevent the oral mucositis in head and neck cancer patients.
  April 2015 ,Medscape Medical News,Newer Herpes Zoster Vaccine Effective Even in Older Adults,"A recombinant subunit vaccine significantly lowered the risk for herpes zoster in adults aged 50 years or older, with comparable efficacy in adults aged 70 years or older."
  April 2015 ,Medscape Medical News,SONATA: 50% Adverse Event Rate Reported for Lifitegrast,"About half the patients with dry eyes who were treated with the experimental drug lifitegrast experienced treatment-emergent adverse events, although not severe ones, a new study has shown."
  April 2015 ,FDA Approvals,FDA Okays First Aripiprazole Generics,The FDA has approved the first generic versions of the atypical antipsychotic aripiprazole.
  April 2015 ,Medscape Medical News,"Novel Brain Stimulation May Boost Creativity, Treat Depression","Low-energy brain stimulation can increase creativity via alpha oscillations, boosting creativity and potentially providing a novel treatment for depression."
  April 2015 ,Medscape Medical News,"Experimental Drug Safe, Effective in Schizophrenia",An experimental agent with a novel mechanism of action may offer a safe and effective treatment option for schizophrenia with a better side effect profile than atypical antipsychotics.
  April 2015 ,Heartwire from Medscape,Statins in Everyone 75 and Older? Could Be Cost-Effective: Analysis,"Perhaps, but ""even very modest adverse effects attributable to statins tip the balance in the direction of harm,"" says an observer, who adds, regarding statins in this group, ""Less is more."""
  April 2015 ,News Alerts,EMA: Heart Risk From Amiodarone Plus Hepatitis C Antivirals," The caution applies to several medications with sofosbuvir, used to fight hepatitis C; the caution in Europe mirrors similar antiviral labeling changes     announced by the US FDA within the past month."
  April 2015 ,Medscape Medical News,Once-Daily Oral Combination Clears Hepatitis C in 95%,"After 12 weeks of treatment with a fixed-dose combination of grazoprevir and elbasvir, hepatitis C RNA levels were undetectable in 95% of patients, a new study has shown."
  April 2015 ,Medscape Medical News,Topical Gel Promising in Migraine , A ketoprofen gel applied on the face over transgeminal nerve endings is effective in migraine treatment and an alternative to those who can't take oral NSAIDs.
  April 2015 ,Medscape Medical News,"Walking Improves Mood, Boosts Energy in Cancer Survivors","New studies admonish cancer survivors to keep moving, as they show that moderate physical exercise improves mood, reduces fatigue, and reduces the adverse effects of chemotherapy."
  April 2015 ,Medscape Medical News,Positive Results for Status Epilepticus Drug  ,Results of phase 1/2 study of new agent for super resistant status epilepticus called 'very exciting' by researchers; a phase 3 trial is planned for later this year.
  April 2015 ,Medscape Medical News,Clozapine-Induced Myocarditis Overlooked?,A purportedly higher incidence of clozapine-induced myocarditis in Australia has led researchers there to warn that this adverse drug reaction is being overlooked elsewhere.
  April 2015 ,Medscape Medical News,"MMR Vaccine Not Linked to Autism, Even in High-Risk Kids","Receipt of the MMR vaccine was not linked to an increased risk for autism spectrum disorder, even when older siblings had the disorder, a new study has shown. "
  April 2015 ,Medscape Medical News,Evidence Points to Fallopian-tube Origins of Ovarian Cancer,Removing just the fallopian tubes and leaving ovaries intact is an experiemtal  option that avoids surgical menopause in younger women at risk for ovarian cancer.
  April 2015 ,Medscape Medical News,New AAN/AES Guideline on First Unprovoked Seizure in Adults,Experts recommend clinicians approach patients on an individualized basis in terms of whether to treat with an antiepileptic drug following a first unprovoked seizure.
  April 2015 ,Medscape Medical News,Vandetanib for Medullary Thyroid Cancer: Manageable Toxicity,"A study of patients with advanced medullary thyroid cancer who received vandetanib outside of a clinical trial showed that this drug can be effective, with     mostly manageable adverse effects."
  April 2015 ,Medscape Medical News,Paradigm Shift: Anti-PD-1 Keytruda Tops Yervoy for Melanoma ,"The newer drug, pembrolizumab, is a better first-line therapy than ipilimumab for advanced melanoma."
  April 2015 ,News Alerts,HCV Antiviral Simeprevir Label Warns of Cardiac Risk,The approved labeling change from the FDA warns of an increased risk of bradycardia with simeprevir when it is used in combination with amiodarone and     sofosbuvir.
  May 2015 ,News Alerts,Confusing Zerbaxa Label Could Lead to Dosing Errors: FDA,"Seven reported cases of dosing errors for the dual antibacterial ceftolozane/tazobactam prompts FDA to issue safety communication, change label. "
  May 2015 ,Medscape Medical News,Chronic Vardenafil Treatment Has CV Benefits in Type 2 Diabetes," Six months of vardenafil therapy in type 2 diabetes lowers inflammation, improves endothelial function, and prompts a rise in testosterone levels in a     small study in hypogonadal men."
  May 2015 ,Heartwire from Medscape,Elderly's Fall Risk With HTN Meds Highest in the Short Term,"It's when starting patients on antihypertensive therapy, as well as when titrating upward or adding a new class of agent, that clinicians need to be more cautious, say investigators."
  May 2015 ,Medscape Medical News,Experimental Kappa Opioid Appears Safe and Effective,"New phase 2 trials show that an experimental kappa opioid agonist, CR845, can reduce pain with few adverse effects and without much potential for abuse."
  May 2015 ,Medscape Medical News,No New Safety Signals for Botox in Incontinence,"Chronic onabotulinumtoxinA use is safe for patients with urinary incontinence, but the catheterization rate might be higher than previously thought."
  May 2015 ,News Alerts,SGLT2 Inhibitor Diabetes Drugs May Cause Ketoacidosis: FDA,Reports of ketoacidosis requiring hospitalization in patients with type 2 diabetes taking sodium-glucose cotransporter-2 inhibitors prompts FDA drug safety communication. 
  May 2015 ,Medscape Medical News,Cognitive Impairment Linked to Androgen Deprivation Therapy,"Men receiving androgen deprivation therapy for treating prostate cancer are likely to experience cognitive impairment, a new study suggests."
  May 2015 ,Heartwire from Medscape,Falls Not a Major Risk in Seniors on BP-Lowering Therapy: Study,"With antihypertensive therapy, ""we need not worry much about precipitating falls, and in the case of ACE inhibitors and calcium-channel blockers, we may actually reduce that risk,"" a researcher says. "
  May 2015 ,Medscape Medical News,Investigational Drug Effective in Partial-Onset Seizures, Results of a phase 3 study of brivaracetam also show the drug is well tolerated with low discontinuation rates.
  May 2015 ,Medscape Medical News,"Patients Commonly Stop Antidepressants, Don't Tell Docs",Roughly 1 in 5 patients stop taking their antidepressant without telling their doctor.
  May 2015 ,Medscape Medical News,Nitrous Oxide Improves Satisfaction With IUD Insertion,"Women who inhaled nitrous oxide during intrauterine device (IUD) insertion reported greater satisfaction with the procedure, although pain scores remained unchanged, according to new research."
  May 2015 ,Medscape Medical News,Bill Aims to Expand Drug Indications Minus Randomized Trials ,"The latest draft of 21st Century Cures wins kudos for budgeting more for NIH, but some experts still worry that it would lower the scientific bar for FDA approvals."
  May 2015 ,Medscape Medical News,ASTRO Issues New Radiotherapy Guidelines for NSCLC,The American Society for Radiation Oncology has issued a new guideline for the use of definitive and adjuvant radiotherapy in patients with locally advanced non-small cell lung cancer.
  May 2015 ,Medscape Medical News,"New Antibiotics Promising in Pneumonia, Abdominal Infection","Alternatives to treat drug-resistant bacteria are on the horizon, including a macrolide for community-acquired pneumonia and a tetracycline derivative for complicated abdominal infections."
  May 2015 ,Medscape Medical News,SWOG Study: 2 Effective Pills for AI-Related Pain Relief,Investigators can't account for the strong showing of a soybean and corn oil capsule in a randomized trial of omega-3 fatty acids for aromatase-inhibitor-linked joint aches.
  May 2015 ,Reuters Health Information,"Sodium Nitrite, Citric Acid Creams Helpful for Anogenital Warts","Twice-daily application of sodium nitrite and citric acid creams cleared anogenital warts more effectively than placebo, researchers say."
  May 2015 ,Medscape Medical News,How to Treat Side Effects of New Cancer Immunotherapies,A new review article details the major side effects of immunotherapies for cancer and provides advice on how to treat them.
  May 2015 ,Medscape Medical News,Retinal Gene Therapy: Long-term Results Less Than Expected,"Gene therapy for RPE65-associated Leber's congenital amaurosis enabled people to see, but the benefit diminished as photoreceptors continued to degrade in patients treated in two trials."
  May 2015 ,Heartwire from Medscape,Ivabradine (Corlanor) US Approval for HF 'Out of the Blue',"Reactions to recent FDA approval of the drug, which lowers heart rate, include enthusiasm, cautious optimism, and concerns over the way the process was     conducted, especially because of what was left out."
  May 2015 ,Medscape Medical News,No Need for Premedication Before Blood Transfusion,"Medicating oncology patients prior to blood transfusion is not really necessary, a new study concludes."
  June 2015 ,Medscape Medical News,Whole-Brain Radiotherapy: Risks Worth Benefit?,"Whole-brain radiotherapy should be avoided in patients with brain metastases because it does not prolong survival, it reduces quality of life, and it causes cognitive decline."
  June 2015 ,Medscape Medical News,Potential Practice Change in Management of DCIS,"In a major clinical trial, an aromatase inhibitor was more effective than tamoxifen in preventing disease recurrence."
  June 2015 ,Medscape Medical News,ADA: Two Big Trials and Special 75th Anniversary Celebration ," Results from two major cardiovascular-outcomes trials will be presented at the 2015 American Diabetes Association Scientific Sessions, as speakers mark 75     years of progress and move the field forward."
  May 2015 ,News Alerts,Sunday at ASCO: News That Will Affect Clinical Practice,Today's news from the ASCO meeting comes from the plenary sessions and is expected to have an immediate impact on clinical practice.
  May 2015 ,Medscape Medical News,New Myelofibrosis Drug Works Even With Thrombocytopenia ,"The new drug can be used even in patients with low platelet counts, a subset of patients for which there is currently no approved therapy. "
  May 2015 ,News Alerts,Saturday at ASCO: Changes for Prostate Cancer & Melanoma,Among the news released today are studies that have potential to change current practice in prostate cancer and melanoma.
  May 2015 ,FDA Approvals,FDA Clears Sirolimus (Rapamune) for Rare Lung Disease,"Sirolimus is the first drug approved in the US to treat lymphangioleiomyomatosis (LAM), a very rare, progressive lung disease that primarily affects women of childbearing age. "
  May 2015 ,Medscape Medical News,Add Liver Cancer to Nivolumab's List of Victims,"The results are only from a phase 1/2 study, but the percentage of responders compares favorably to currently available systemic therapy."
  May 2015 ,Medscape Medical News,Combination Therapy Improves Bladder Control,"Adding mirabegron to solifenacin treatment for overactive bladder appears to improve control without increasing adverse effects, results from the BESIDE trial show."
  May 2015 ,Medscape Medical News,Statins Questionable for Elderly Men Without Heart Disease,"For men older than 70 years, the reduction in risk for a first major cardiovascular event with statin use is not significant, a retrospective study has shown."
  May 2015 ,Medscape Medical News,"Cannabis Smoking Common, Affects Cognition in MS  ","Cannabis smoking is common among patients with MS, who use it to control pain and spasticity, but the downside is that it may have lasting effects on memory and other cognitive functions."
  May 2015 ,Medscape Medical News,Febuxostat More Effective Than Allopurinol at Usual Doses,"At commonly used doses, febuxostat was more effective than allopurinol at reducing serum uric acid in patients with gout, but allopurinol was likely underdosed. "
  May 2015 ,Medscape Medical News,Prepare for Questions on Cannabis as an Analgesic,"Cannabis is becoming increasingly important in pain control, and clinicians must prepare to answer patients' questions about it, according to a leading researcher. "
  May 2015 ,Medscape Medical News,Psychomotor Speed Flags DBS Responders With Severe Depression,Psychomotor speed may identify which patients with treatment-resistant depression will respond to deep brain stimulation.
  May 2015 ,Medscape Medical News,US and Europe Differ on Use of Vaptans in Hyponatremia,"  A lively debate was held at the recent endocrinology meeting in Dublin about which are the better guidelines for treatment of hyponatremia, those of the US or     Europe, centered on use of vaptans."
  May 2015 ,Medscape Medical News,New Drug Treatments for Basal Cell Carcinoma,"New studies in patients with advanced basal cell carcinoma show long-term safety of vismodegib, and also profile a new drug, sonidegib, which is awaiting approval."
  May 2015 ,Medscape Medical News,e-Cigarettes of Questionable Value for Quitting Smoking,"Evidence is sparse, but a meta-analysis shows that e-cigarettes are associated with a 50% reduction of cigarette use at 6 months and are of no benefit in complete cessation."
  May 2015 ,Medscape Medical News,Brain Stimulation Techniques Promising for Resistant OCD,DBS is enjoying something of a comeback with new research on this and other modes of brain stimulation showing encouraging results in treatment-resistant obsessive- compulsive disorder.
  May 2015 ,Medscape Medical News,What's Hot at ASCO 2015?,This year's meeting focusses on 'transforming data into learning' to speed up the process of applying results from clinical trials into patient care.
  May 2015 ,Medscape Medical News,"Marijuana Doesn't Curb Agitation, Aggression in Dementia","However, the absence of major adverse effects in a study of low-dose oral tetrahydrocannabinol leaves room for testing a higher dose, researchers say."
  June 2015 ,Medscape Medical News,Chronic Use of Proton Pump Inhibitors Increases Heart Risk ,A new study showed increased cardiovascular risk with proton-pump inhibitors in the general population; patients should use the lowest effective dose required to treat symptoms.
  June 2015 ,Medscape Medical News,Practical Advice for Treating Skin Toxicity of Regorafenib,New review offers expert advice for treating hand-foot skin reactions associated with regorafenib treatment. 
  June 2015 ,Medscape Medical News,Higher Fees Could Offset Care Benefits of Physician Mergers ,A study has found that arthroplasty fees rose by 7% per procedure in the most concentrated orthopedic markets.
  June 2015 ,Medscape Medical News,ESMO Unveils Scale for Assessing Value of Cancer Drugs,ESMO says that it intends to apply the scale prospectively to new anticancer drugs that will be approved by the EMA. 
  June 2015 ,Medscape Medical News,Geriatrics Society Updates List of Inappropriate Drugs,The American Geriatrics Society is updating its list of medications that can be problematic for older adults. Controversial changes to the so-called Beers Criteria are in the works.
  June 2015 ,Medscape Medical News,"Lithium Linked to Renal, Endocrine Function","Lithium, the cornerstone treatment for bipolar disorder, has been linked to renal, thyroid, and parathyroid dysfunction."
  June 2015 ,Medscape Medical News,Antipsychotics as First-Line Insomnia Treatment a No-No,"Leading Canadian psychiatric organizations have come out against the routine use of antipsychotics as first-line treatment for insomnia in children, adults, and the elderly."
  June 2015 ,Medscape Medical News,Embattled Dr Oz Show Hires Physician From Consumer Reports ,Dr Crupain is a preventive medicine specialist and nutrition expert who says he is passionate about 'evidence-based' approaches to health. The show has been criticized for giving unscientific advice.
  June 2015 ,Reuters Health Information,Metformin May Lower Risk of Glaucoma in Elderly,"Metformin, in addition to lowering blood sugar, may also reduce the risk of open-angle glaucoma, a new study suggests."
  June 2015 ,Medscape Medical News,TNF Inhibition for Alzheimer's Dementia Falls Short ,"Weekly subcutaneous etanercept proves safe in AD dementia, with a hint of benefit on psychiatric but not cognitive symptoms in a proof-of-concept phase 2 trial. Further study is planned. "
  June 2015 ,Medscape Medical News,"Leukemia Drug Is 'Blessing From God,' But Trial Imperfect",Is ibrutinib plus immunochemotherapy the best treatment for chronic lymphocytic leukemia? Go to HELIOS to find out.
  June 2015 ,Heartwire from Medscape,'Guarded Enthusiasm' Builds for PCSK9 Inhibitors,"The excitement is real, but with next week's FDA advisory panels on two new PCSK9 inhibitors, physicians are starting to think through tough questions     about how to actually use the agents in clinical practice."
  June 2015 ,Medscape Medical News,Direct Current Stimulation Boosts Cognition in Schizophrenia,"Transcranial direct current stimulation improves memory, verbal fluency in patients with schizophrenia, but will it last?"
  June 2015 ,Medscape Medical News,Sleep Apnea: Mixed Results for Mandibular Appliance,"Mandibular advancement devices improved apneas and hypopneas, but did not improve daytime sleepiness or quality of life, in patients with snoring or mild to moderate obstructive sleep apnea."
  June 2015 ,Medscape Medical News,Cost Changes Conclusion From Major CRC Trial,"Last year, the conclusion was that each of two colorectal cancer treatments were equally effective, and so either could be used. What a diference a year makes."
  June 2015 ,FDA Approvals,FDA Okays Topiramate ER (Qudexy) Monotherapy in Children ,Once-a-day capsules are now approved as initial monotherapy for children aged 2 years and up with partial-onset seizures or primary generalized tonic-clonic seizures.
  June 2015 ,Medscape Medical News,Some Bird Flu Viruses in US Potential Threat to Humans: CDC,"Birds infected with highly pathogenic avian influenza A H5 viruses in the United States could cause human infection, the CDC says in a new advisory."
  June 2015 ,Medscape Medical News,Novel Testosterones May Overcome Oral Dosing Hurdles,New oral formulations appear to normalize testosterone levels in hypogonadal men and could help overcome the challenges associated with oral dosing.
  June 2015 ,Medscape Medical News,Effects of Alemtuzumab in MS Persist at 4 Years,Positive effects of the drug in patients with  relapsing-remitting multiple sclerosis who have very active disease may continue to 4 years. 
  June 2015 ,Medscape Medical News,Unprecedented Responses With Daratumumab in Multiple Myeloma,The novel anti-CD38 agent produced 'unprecedented overall responses' in heavily pretreated multiple myeloma patients.
  June 2015 ,Medscape Medical News,Novel Drug Mechanism Addresses Parkinson's Psychosis,"An antipsychotic drug with a novel, nondopaminergic mechanism may allow better treatment of Parkinson's psychosis and better use of dopaminergic drugs. A study has shown persistent efficacy."
  June 2015 ,Medscape Medical News,New 'Multiple-Source' DBS Device Looks Good for Parkinson's ,The first clinical study with a new-generation system of deep-brain stimulation for Parkinson's disease has shown promising results. 
  June 2015 ,News Alerts,EMA Panel Likes Multiple Myeloma and Skin Cancer Drugs,Two Novartis agents got positive reviews from European authorities.
  June 2015 ,Medscape Medical News,Another PFO Closure Study Yields Mixed Migraine Results ,The latest trial to investigate patent foramen ovale closure as potential treatment for refractory migraine has again yielded overall negative results but suggests possible benefit for those with aura.  
  June 2015 ,Medscape Medical News,Topical Cyclosporine Better for Ocular Rosacea,A new comparative study has found that topical cyclosporine is more effective than oral doxycycline at relieving symptoms and treating eyelid and dry eye signs in patients with ocular rosacea. 
  June 2015 ,Medscape Medical News,'Game Changer' for First-Episode Schizophrenia,"A long-acting injectable antipsychotic proved far superior to an oral antipsychotic after a first psychotic episode and should be first-line treatment, new research suggests."
  June 2015 ,Medscape Medical News,Vitamin D Improves Depression in Women With Liver Disease,Symptoms of depression improve in women with chronic liver disease when treated for vitamin D deficiency.
  June 2015 ,Medscape Medical News,New Data on CGRP Monoclonal Antibodies for Migraine Prevention,"Phase 2 data on calcitonin gene-related peptide monoclonal antibodies show efficacy and safety as potential novel migraine preventives, but experts say larger and longer studies are needed.   "
  June 2015 ,Medscape Medical News,ASCO Wants Your Feedback on Plan to Define Value in Drugs,"ASCO has published a draft conceptual framework for assessing the value of new cancer treatment options based on benefit, toxicity, and cost and is seeking public feedback to refine the strategy."
  June 2015 ,Medscape Medical News,Kids With Migraine Not Receiving Optimal Treatment ,"Two studies reveal that half of kids with migraine or probable migraine aren't receiving any treatment, very few are receiving evidence-based treatment, and one in six are given opioids. "
  June 2015 ,Medscape Medical News,New Drug for Rett Syndrome?,"Research shows that a new investigational drug is safe, well tolerated, and effective in managing core symptoms of this neurodegenerative genetic disorder."
  June 2015 ,Medscape Medical News,Medical Marijuana Laws Don't Encourage Teen Use,"A multiyear nationwide survey suggests that introducing state medical marijuana laws does not lead to an increase in marijuana use in adolescents, although those states have higher overall usage."
  June 2015 ,Reuters Health Information,Long-Term Topical Corticosteroids Best for Vulvar Lichen Sclerosus,"Individualized preventive topical corticosteroid (TCS) regimens are best for the long-term management of adult vulvar lichen sclerosus (VLS), according to a longitudinal study in 507 women."
  June 2015 ,Medscape Medical News,"Too Many Patients With Migraine Receiving Opioids, Barbiturates ","A new survey reveals that half of patients with migraine are receiving medications that are not recommended as first-line and that may lead to overdose, addiction, and more frequent headaches.  "
  June 2015 ,Medscape Medical News,Breast Cancer Trial Results Spin a Cautionary Tale,"Some clinicians switched to newer, costlier, and more toxic drugs for advanced breast cancer before completion of a head-to-head trial showing that the old drug was similarly effective, cheapest, and least toxic."
  June 2015 ,Medscape Medical News,New Oral Biologic Improves Symptoms in Refractory RA,"A new oral JAK1/JAK2 inhibitor produces rapid clinical improvement in patients with refractory rheumatoid arthritis (RA), despite previous exposure to multiple biologic agents."
  June 2015 ,Medscape Medical News,"Higher Stroke, Death With Balloon Inflation After Carotid Stent ","Patients undergoing carotid stenting appear to have a lower risk for stroke or death if they do not undergo post-stenting balloon inflation, a new study suggests. "
  June 2015 ,News Alerts,"FDA Okays Current Label to Manage Eye, Skin Problems With Potiga",The FDA announced today that the 2013 label changes for the antiseizure drug ezogabine (Potiga) are sufficient to prevent retinal abnormalities and skin discoloration seen with the drug.  
  June 2015 ,Medscape Medical News,NSAIDs Dramatically Reduce Ovulation With Consistent Use,"When taken during the luteal phase of the menstrual cycle, NSAIDs can inhibit ovulation and could significantly impair fertility in women trying to get pregnant."
  June 2015 ,Medscape Medical News,Synthetic Marijuana an Urgent Public Health Threat,"Calls to poison control centers related to synthetic marijuana jumped 229% in the first 5 months of 2015, prompting calls to get the products off the market."
  July 2015 ,Medscape Medical News,Chemoradiotherapy Widens Options in Rectal Cancer  ,Patients with resectable low rectal cancer could safely undergo chemoradiotherapy and then watchful waiting as an alternative to surgery.
  July 2015 ,FDA Approvals,"Iressa Back in the US for Lung Cancer, Now as First-Line  ","Finally, the targeted therapy is available again in the United States. "
  July 2015 ,News Alerts,Safety Profile of HPV Vaccines Under Review in Europe ,The European Medicines Agency is reviewing the safety profile of human papilloma virus vaccines but says there should be no change in their use at this time.
  July 2015 ,Medscape Medical News,Physician Who Gave Unneeded Chemo Gets 45 Years in Prison,"Farid Fata, MD, 'practiced greed and shut down whatever compassion he had,' said US District Judge Paul Borman, who called the oncologist's crimes 'horrific.'"
  July 2015 ,Medscape Medical News,New Abacus Calculates Price of Cancer Drug Based on Value,An innovative interactive tool developed at Memorial Sloan Kettering Cancer Center tries to put drug costs in context with their overall value.
  July 2015 ,Medscape Medical News,FDA Panel Says Necitumumab Has Benefit in Squamous NSCLC,The monoclonal antibody could be approved by late 2015.
  July 2015 ,Medscape Medical News,Pinaverium Effectively Treats IBS Symptoms in RCT ,Patients with irritable bowel syndrome who took pinaverium had significant improvement in abdominal pain and stool consistency compared with patients who took placebo in the double-blind trial.
  July 2015 ,Medscape Medical News,Immunotherapy Moves to Community Cancer Setting,A first-of-its-kind initiative aimed to facilitate the adoption of immuno-oncology in the community cancer setting has just been launched by the Association of Community Cancer Centers.
  July 2015 ,Medscape Medical News,Uptake of HIV Prevention Starter Kit High in STI Clinics,HIV prevention starter kits are widely accepted at sexually transmitted infection clinics among clientele who are at risk for HIV infection because of high-risk sexual exposure.
  July 2015 ,Reuters Health Information,Acute Kidney Injury May Follow BRAF Inhibitor Treatment,"Several cases of acute kidney injury (AKI) have occurred in patients whose metastatic melanoma was treated with the BRAF inhibitors vemurafenib and dabrafenib, according to findings from the Food and Drug Administration Adverse Event Reporting System (FAERS)."
  July 2015 ,Medscape Medical News,"AIMS Project Improves Adherence, Outcomes in HIV Patients","An intervention designed to help HIV patients improve adherence not only bolsters pill-taking behavior but also reduces the risk for treatment failure, new research shows."
  July 2015 ,Medscape Medical News,Medical Marijuana: Where's the Evidence?   ,"Two new reviews highlight the lack of evidence to support the use of medical marijuana for most indications, leading to questions about the legal implications for doctors prescribing such products.   "
  July 2015 ,FDA Approvals,FDA Clears Combo Drug Orkambi for Cystic Fibrosis,Orkambi combines the approved drug ivacaftor (Kalydeco) with lumacaftor and is indicated for patients with CF aged 12 years and older with two copies of the F508del mutation. 
  July 2015 ,Heartwire from Medscape,Endovascular Cooling for OOH Arrest: Little Clinical Gain Seen," ""Despite better hypothermia induction and maintenance,"" endovascular wasn't superior to external cooling in survival without major neurological damages,     say researchers. But they also saw room for optimism."
  July 2015 ,Heartwire from Medscape,ICD Recruited for Paddle-Free AF Cardioversion in Small Study,"""This method is less time-consuming and does not necessitate deep anesthesia compared with external   cardioversion,"" says the lead author. But advantages     over the standard method remain hypothetical."
  July 2015 ,News Alerts,FDA Reviewing Safety of Codeine for Cough in Kids Under 18 ,The FDA is investigating the safety of using codeine-containing medicines to treat coughs and colds in children younger than 18 years because of the potential for serious adverse effects. 
  June 2015 ,Reuters Health Information,California Governor Signs Bill Limiting School Vaccine Exemptions,California Governor Jerry Brown on Tuesday signed a bill eliminating the state's personal beliefs exemption for school vaccine requirements - legislation that was prompted by a measles outbreak at Disneyland linked to low vaccination rates.
  June 2015 ,Medscape Medical News,High-Dose Baclofen Supports Abstinence in Alcoholism,High-dose baclofen supports abstinence among alcohol-dependent patients compared with placebo and is reasonably well tolerated.
  June 2015 ,International Approvals,CHMP Backs Three Drugs for Rare Diseases ,"The EMA committee backs treatments for lysosomal acid lipase deficiency, alpha1-proteinase inhibitor deficiency, and Leber's hereditary optic neuropathy."
  June 2015 ,Medscape Medical News,ACOG Updates Recommendations to Include 9-Valent HPV Vaccine ,"Only half of teenaged girls have received one dose of the HPV vaccine, but coverage of 80% would reduce cervical cancer burden by 53,000 cases. "
  July 2015 ,FDA Approvals,FDA Clears Two New Oral Drugs for Hepatitis C ,"Technivie, for genotype 4 infection, combines ombitasvir, paritaprevir, and ritonavir and is for use with ribavirin. Daclatasvir, for use with sofosbuvir, is for genotype 3 infection."
  July 2015 ,News Alerts,FDA Approves Sonidegib (Odomzo) for Basal Cell Carcinoma,The drug is indicated for use in locally advanced disease
  July 2015 ,International Approvals,Sufentanil Hybrid Receives CHMP Nod for Post-Op Pain ,"The new product, Zalviso, is similar to another sufentanil-containing anesthetic-analgesic that has been available in the Netherlands for decades. "
  July 2015 ,Medscape Medical News,"AIs, Bisphosphonates Save Lives in Postmenopausal Breast Ca",Aromatase inhibitors (AIs) and bisphosphonates both reduce early breast cancer recurrence and mortality in postmenopausal women.
  July 2015 ,News Alerts,CHMP Recommends ADHD Drug for Approval,An EMA committee recommended guanfacine in combination with comprehensive behavioral therapy for children and adolescents 6 to 17 years old with attention-deficit/hyperactivity disorder.
  July 2015 ,Medscape Medical News,"Positive Biomarker Data for AD Drug, but No Clinical Benefit","A biomarker analysis shows the antiamyloid agent gantenerumab yields dose-dependent reductions in brain amyloid and markers of neuronal injury, suggesting the tested dose may have been too low."
  July 2015 ,Medscape Medical News,CDC: Hispanics More Likely to Believe Antibiotics Lessen Colds,"US Hispanics are almost twice as likely as all patients to believe that taking antibiotics reduces cold symptoms, and nearly three times as likely to obtain antibiotics not prescribed by a clinician."
  July 2015 ,Medscape Medical News,Nondaily Treatment an Option for Those at High Risk for HIV,"For some people, nondaily pre-exposure prophylaxis is feasible, although adherence and protection is better with daily administration, results from the ADAPT trial show."
  July 2015 ,Heartwire from Medscape,Meta-Analysis: Cognitive Decline Rare After CV Procedures,"""The general perception has been there were significant adverse cognitive effects"" after these treatments, say researchers. But results suggest that     clinicians ""can be a little reassuring"" to patients."
  July 2015 ,Medscape Medical News,Calmangafodipir May Reduce Chemo-Induced Neuropathy,"In colorectal cancer patients treated with the FOLFOX regimen, calmangafodipir reduced the incidence of chemotherapy-induced peripheral neuropathy."
  July 2015 ,Medscape Medical News,Could Dexamethasone Dose Affect Glioblastoma Survival?,"Dexamethasone is routinely used in the clinical management of glioblastoma, but a new study suggests that high-dose dexamethasone could affect survival."
  July 2015 ,Medscape Medical News,Ultrabrief ECT for Depression May Trump Standard ECT,An analysis suggests efficacy similar to that of brief pulse electroconvulsive therapy but with fewer cognitive side effects.
  July 2015 ,Medscape Medical News,"Rivastigmine Improves Gait, Reduces Falls in Parkinson's","Rivastigmine improved gait in patients with Parkinson's disease and reduced frequency of falls. Falls are a major concern for patients, and fear of falling can lead to loss of mobility and social isolation."
  July 2015 ,Medscape Medical News,Illicit Use of 'Bath Salts' in Teens Much Lower Than Expected,"A survey of high school seniors has found that just a small minority report using bath salts, but the researchers caution more might be using the psychoactive recreational drug without knowing it."
  July 2015 ,Medscape Medical News,Patiromer Study Published: Approval for Hyperkalemia Soon?,"A study author says this is the first predictable, well-tolerated potassium binder and will change treatment for life-threatening hyperkalemia. FDA approval     could come this fall."
  July 2015 ,Medscape Medical News,Pneumonitis an Adverse Effect of PD-Inhibitor Immunotherapy ,Clinicians treating melanoma with programmed cell death (PD) inhibitors report autoimmune pneumonitis as a rare but potentially serious toxic effect.  
  July 2015 ,Medscape Medical News,"Vasomotor Symptoms Relieved by Escitalopram, E2, Venlafaxine","Menopausal women with moderate vasomotor symptoms may find relief from escitalopram, low-dose dose oral 17-beta-estradiol, or venlafaxine, according to a pooled analysis."
  July 2015 ,News Alerts,Mylan Withdraws 14 Lots of Calcium Chloride Prefilled Syringes ,The action is a precautionary measure as a result of customer complaints citing difficulties in administration of the drug.
  July 2015 ,Medscape Medical News,Single-Dose IV Fosaprepitant Effective for CINV,A single IV dose of fosaprepitant was effective and safe for treating nausea and vomiting in subjects undergoing moderately emetogenic chemotherapy.
  July 2015 ,Medscape Medical News,Diabetes Drug Metformin: No Impact on Birth Weight in Obese Pregnancy,A metformin study is one of the first clinical trials to investigate preventive treatment in obese pregnant women to protect the unborn child from     long-term effects.
  August 2015 ,Medscape Medical News,Pancreatic Cancer: Who Is Likely to Respond to FOLFIRINOX,The enzyme CES2 may identify patients with pancreatic cancer who are likely to respond to treatment with irinotecan in the FOLFIRINOX regimen.
  August 2015 ,Medscape Medical News,"Ipilimumab Side Effects in Real World, and What to Do",Real-world immune-related adverse events with ipilimumab may be higher than clinical trials suggest; experts give advice on how to deal with them.
  August 2015 ,FDA Approvals,FDA Approves 'Female Viagra' Flibanserin (Addyi),The manufacturer aims to have the drug available for sale starting October 17.
  August 2015 ,Medscape Medical News,Dementia Drugs Linked to Serious Weight Loss,"Cholinesterase inhibitors, commonly used to treat dementia, are associated with significant, potentially serious, weight loss in elderly dementia patients."
  August 2015 ,Medscape Medical News,New Hydrogel Drug-Delivery Method Targets Colon Inflammation,A preclinical study has shown that hydrogel loaded with dexamethasone reduced epithelial inflammation in the colon more than free dexamethasone.
  August 2015 ,Medscape Medical News,"Antidepressants in Pregnancy: Good News, Bad News","SSRIs in pregnant women with depression have been linked to reduced rates of preterm birth and cesarean delivery. However, the drugs are also tied to a higher risk for neonatal complications."
  August 2015 ,Medscape Medical News,Memory Problems Due to 'Cancer Brain' and Not 'Chemo Brain'?,A study in postmenopausal women with newly diagnosed breast cancer has linked pretreatment cytokine levels to memory problems.
  August 2015 ,Medscape Medical News,"NICE Still Has It Wrong on Type 2 Diabetes Guidance, Say Docs","UK NICE is wedded to some illogical recommendations with regard to pharmacotherapy of type 2 diabetes in the latest draft of its new guidance on treatment,     says a group of experts."
  August 2015 ,Medscape Medical News,Seniors Twice as Likely to Receive Psychotropic Meds,"Older adults are more likely to receive psychotropic medications and less likely to see a psychiatrist than younger adults, data from a major health survey indicate."
  August 2015 ,Medscape Medical News,'Female Viagra' Foes Denounce PR Campaign to Win FDA Approval,Opponents of flibanserin say an orchestrated appeal to gender justice masks the marginal effectiveness and significant health risks of a drug for low female libido.
  August 2015 ,Kaiser Health News,Reduced Access to Meds After Crackdown on Illegal Rx Drug Trade, An unintended side effect of a crackdown on prescription drug abuse affects chronic pain patients’ access to medication.
  August 2015 ,Medscape Medical News,'Mounting Evidence' for Hypofractionation in Breast Cancer,Two studies add support for hypofractionation of radiation following surgery for early-stage breast cancer.
  July 2015 ,Medscape Medical News,'Sensational' Hep C Response Rates in HIV Coinfection Trial,C-EDGE trial investigators report very high sustained virologic response rates in patients taking grazoprevir and elbasvir coformulated in a single tablet.
  July 2015 ,Medscape Medical News,Did HHS Cancel Proposed FDA Limits on Mercury Fillings?,"""We are still working on securing (HHS) clearance,"" an FDA official told an attorney in a lawsuit seeking to ban the use of dental amalgam in pregnant women, nursing mothers, and children aged less than 6 years."
  July 2015 ,Medscape Medical News,Large Study Backs Switch to Next-Gen Tenofovir for HIV,"Tenofovir alafenamide is as effective as the standard formulation in maintaining viral suppression over 48 weeks, and might have bone- and renal-sparing effects, report investigators."
  July 2015 ,Orphan Drug Approvals,CHMP Backs Antifungal Isavuconazole (Cresemba),The triazole antifungal is indicated for treatment of adults with invasive aspergillosis and mucormycosis in patients for whom amphotericin B is not appropriate. 
  July 2015 ,News Alerts,Teva Recalls Six More Lots of Fluorouracil Injection,The recall of Adrucil is due to the potential presence of particulate matter identified as an aggregate of silicone rubber pieces from a filler diaphragm and fluorouracil crystals.
  July 2015 ,Heartwire from Medscape,"What Now, ARNI? Experts Ponder Newly Arrived Heart-Failure Drug","Although enthusiasm is widespread, ""we aren't ready to offer this to everyone who comes to our office,"" says one expert. ""Especially because we didn't have     the benefit of an FDA panel review."""
  July 2015 ,News Alerts,Gadolinium Brain Deposits on FDA Radar,The FDA is investigating the potential risk for brain deposits with repeated use of gadolinium contrast agents for MRI.
  July 2015 ,Medscape Medical News,SWOG Trial Defines a Regimen for Biliary Cancer,Adjuvant capecitabine and gemcitabine followed by radiotherapy and capecitabine was well tolerated and effective in the treatment of extrahepatic cholangiocarcinoma and gallbladder carcinoma.
  September 2015 ,Medscape Medical News,Leukotriene-Receptor Antagonists Improve Asthma Control,"Leukotriene-receptor antagonists, alone or with inhaled corticosteroids, significantly improved asthma control and reduced exacerbations, according to a systematic review. "
  September 2015 ,News Alerts,FDA Reviewing Risk With Off-Label Tramadol Use in Children,The FDA is investigating the risk for respiratory problems in children aged 17 years and younger treated with the pain medication tramadol. 
  September 2015 ,Medscape Medical News,Case Reports of 'Syndrome' Appearing After HPV Vaccination,"Clinicians are reporting a syndrome of pain, fatigue, and autonomic dysfunction appearing after human papillomavirus (HPV) vaccination. "
  September 2015 ,News Alerts,FDA Investigates Risk for Reprocessed Bronchoscopes,"So far, the agency has found that problems revolve around not following the manufacturer's directions for reprocessing precisely or not replacing scopes when damage is evident."
  September 2015 ,Medscape Medical News,Tips for Managing CV Toxicity With TKIs in Leukemia Patients,"A new review covers cardiovascular (CV) toxicity for patients with chronic myeloid leukemia (CML) on tyrosine kinase inhibitors (TKIs), and provides practical recommendations on management."
  September 2015 ,FDA Approvals,"FDA Okays New Atypical for Schizophrenia, Bipolar Disorder",The FDA has approved a new atypical antipsychotic for the treatment of schizophrenia and bipolar disorder in adults.
  September 2015 ,Medscape Medical News,Number Using Opioids and Marijuana on the Rise,"A new study shows use of these two drugs together is increasing, which could signal a worrisome trend, researchers say."
  September 2015 ,News Alerts,FDA Strengthens Fracture Warning for Canagliflozin ,"New clinical trial data for canagliflozin confirmed previously noted risk about fractures and reduced bone mineral density in the hip and spine, prompting the FDA to revise the product label. "
  September 2015 ,Heartwire from Medscape,No CVD/Psychiatric Risk With Varenicline: Analysis,"The label warns of the potential for cardiovascular risks with the smoking-cessation aid, as well as a boxed warning concerning neuropsychiatric side     effects, but a new analysis did not find evidence of such risks."
  September 2015 ,Medscape Medical News,EMPA-REG OUTCOME Results Top EASD Agenda in Stockholm,"This year's European Association for the Study of Diabetes Meeting will feature the much-anticipated results of the cardiovascular-outcomes study with     empagliflozin, among other exciting topics."
  September 2015 ,Medscape Medical News,"Test Predicts Drug Response in Depression, Anxiety","Pharmacogenomic testing predicts patient response to psychotropic medications and enhances treatment outcomes by identifying the best drug for individual patients, a new study suggests."
  September 2015 ,Medscape Medical News,Unilateral Equal to Bitemporal ECT in Depression,"High-dose unilateral electroconvulsive therapy is as effective as the more conventional bitemporal approach and has fewer cognitive effects, randomized trial results show."
  September 2015 ,Medscape Medical News,Telomerase Inhibitor Imetelstat Reverses Marrow Fibrosis,"The investigational agent induced complete and partial remissions in some patients with myeloproliferative disorders, but the mechanism of action is unclear. "
  September 2015 ,Heartwire from Medscape,"SCOT: Good Risk/Benefit Trade-Off With Celecoxib, Other NSAIDs","Criticized for its limitations, the trial's researchers say low rates of side effects and CV events in the trial should reassure that celecoxib and     standard NSAIDs can be acceptable chronically in such patients; not all agree."
  September 2015 ,Heartwire from Medscape,"Diuretic Combo Lowers BP, No Effect on Glucose Metabolism","Adding the potassium-sparing diuretic amiloride to HCTZ amplified the blood-pressure reductions of each drug and offset the undesirable changes in blood     glucose and potassium, report the PATHWAY investigators."
  August 2015 ,Reuters Health Information,Ustekinumab Found to Be Effective in Adolescents With Psoriasis,"Adolescents with moderate to severe psoriasis may respond to the human monoclonal antibody ustekinumab as well as adults, with no unexpected side effects, a new study found."
  August 2015 ,Medscape Medical News,PRIDE Continues to Support ECT in Depressed Elderly,Updated findings from the PRIDE trial continue to support right unilateral electrode placement and ultrabrief pulse ECT to achieve robust and rapid response in geriatric major depressive disorder.
  August 2015 ,Heartwire from Medscape,AF Recurs Despite Strategies Added to AF Ablation in Trials," The use of antiarrhythmic drugs for 90 days after an AF ablation did not reduce AF/AT recurrence at 1 year, nor did the use of adenosine to guide     pulmonary-vein isolation ablation procedures, report investigators."
  August 2015 ,Medscape Medical News,Young Women Refuse Tamoxifen Because of Fertility Concerns,"Concerns about fertility can influence adherence to endocrine therapy in young women with breast cancer, a new study suggests."
  August 2015 ,Medscape Medical News,Effectiveness of Cancer Survivorship Care Plans Questioned,"Survivorship care plans have been recommended for cancer survivors to  improve their quality of care, but a Dutch study questions their benefits."
  October 2015 ,FDA Approvals,FDA Clears Two-Drug Combo as First-Line Treatment for PAH,Ambrisentan plus tadalafil in newly diagnosed pulmonary arterial hypertension reduces risk of disease worsening and improves exercise ability. 
  October 2015 ,Medscape Medical News,Brentuximab -- First-Line Option in Elderly Hodgkin's Lymphoma,A phase 2 trial has shown that brentuximab vedotin monotherapy is safe and effective as first-line therapy in elderly lymphoma patients who cannot tolerate standard chemotherapy.
  October 2015 ,Medscape Medical News,"Metformin Intolerance Increased by Genes, Other Meds "," In two studies, certain gene variants and medications that inhibit the action of a metformin transporter in the gut increased the likelihood of drug     gastrointestinal side effects."
  October 2015 ,Medscape Medical News,Novel Interleukin 17 Antibody Quickly Reduces Psoriasis,"Brodalumab cleared 100% of plaque in twice as many patients as ustekinumab, but the safety profile needs more study."
  October 2015 ,Medscape Medical News,Pulmonary Fibrosis Treatment Trickier Than Drug Trials Imply,"In real-world patients with idiopathic pulmonary fibrosis, the mortality rate is higher than clinical trials have suggested, and disease is more severe, a German registry reveals."
  October 2015 ,FDA Approvals,FDA Approves Pembrolizumab for Lung Cancer ,This is the second immunotherapy to be approved for lung cancer; a host of others are waiting in the wings. 
  September 2015 ,Reuters Health Information,Metyrapone Appears Effective in Cushing's Syndrome in Long Term,"The steroidogenesis inhibitor metyrapone appears to be an effective short- and long-term treatment for Cushing's syndrome (CS), according to a new retrospective multicenter study."
  October 2015 ,FDA Approvals,FDA Okays Juvederm Ultra XC for Lip Augmentation,The dermal filler is now indicated for injection into the lips and perioral area for lip augmentation in adults older than 21 years.
  September 2015 ,Medscape Medical News,Synthetic Marijuana Linked to Subarachnoid Hemorrhage,Neurologists are concerned about this possible new adverse effect of chemical-rich synthetic cannabis products.
  September 2015 ,Medscape Medical News,Depression Outcomes Not Improved With Decision Aid for Meds,"A deck of cards meant to help patients and clinicians collaborate on a decision about antidepressants led to better satisfaction for both, but did not improve outcomes or adherence."
  September 2015 ,Reuters Health Information,Intravitreous Melphalan Can Have Anterior Segment Toxic Effects,"Intravitreous injection of melphalan can have toxic effects in the anterior eye segment in addition to well established effects in the posterior segment, a new study shows."
  September 2015 ,Medscape Medical News,Cancer Treatment Should Not Be Delayed During Pregnancy,Women diagnosed with cancer during pregnancy can be safely treated during the second and third trimesters without harming the fetus.
  September 2015 ,Medscape Medical News,Hypertonic Saline Effective for Infants With Bronchiolitis,"Nebulized hypertonic saline is a safe and effective treatment for infants with acute bronchiolitis, according to a new study. "
  September 2015 ,International Approvals,"Genvoya, a Gentler Anti-HIV Cocktail, Okayed by EU Regulators",A new version of tenofovir in the once-a-day tablet makes it safer for bones and kidneys than its predecessor Stribild.
  September 2015 ,Heartwire from Medscape, Poison-Center Data: Factor Xa Inhibitor Bleeding 'Rare'," Overingestion of two NOACs showed bleeding events only after long-term use, and no toxicity in kids who took a family member's pills, leading one expert to     call the study ""a reassuring first step."""
  September 2015 ,Medscape Medical News,Report Endorsing e-Cigarettes Called Into Question,"A report by the government public health agency in England supporting the use of e-cigarettes as a smoking cessation aid is based on insufficient evidence, two experts say."
  September 2015 ,International Approvals,"EU Panel Likes Multiple Myeloma, Leukemia, Melanoma Drugs",A recommendation from the Committee for Medicinal Products for Human Use usually results in eventual marketing approval.
  September 2015 ,International Approvals,CHMP Backs Mepolizumab for Severe Eosinophilic Asthma,The European Medicines Agency committee recommended approval of the novel anti-IL-5 biologic as add-on maintenance treatment in adults with severe refractory eosinophilic asthma.
  September 2015 ,Medscape Medical News,Switching AED Forms Improves Seizure Control for ID Patients,"Seizure control improved by 50% when patients with epilepsy and intellectual disability were switched from a liquid to a granule form of levetiracetam, a study shows. Gut absorption may be the reason."
  September 2015 ,News Alerts,FDA Warns of Risk for Dosing Errors With Avycaz,Three reports of medication errors caused by confusion over the drug strength displayed on the label of the intravenous antibacterial combination ceftazidime-avibactam (Avycaz) prompts label change. 
  October 2015 ,Medscape Medical News,Simplified Antiretrovirals Outperform Typical HIV Treatment,"Viral suppression at 48 weeks was better with a two-pill regimen than a with a conventional five-pill antiretroviral approach, a new study indicates."
  October 2015 ,FDA Approvals,FDA Approves Praxbind to Reverse Anticoagulant Pradaxa," The FDA has approved Praxbind, a drug designed to rapidly reverse the anticoagulant effects of Pradaxa."
  October 2015 ,Medscape Medical News,'Ground-Breaking' Ocrelizumab Data Dominate ECTRIMS,The results of three new phase 3 studies with the new anti-B cell humanized antibody for multiple sclerosis were the major talking point among delegates attending the recent ECTRIMS meeting in Barcelona. 
  October 2015 ,Medscape Medical News,Homeopathy Doc Gives Up Florida License After Toddler Death,"The medical examiner ruled no intent to cause harm, but two medical boards found substandard care. "
  October 2015 ,Medscape Medical News,Epilepsy App Tracks Seizures,"Information gathered with the new interactive app, downloaded to the Apple Watch, will be used to develop a seizure detector."
  October 2015 ,Medscape Medical News,Does Exercise Improve Survival in Cancer?,"Evidence suggests that exercise and other lifestyle changes may protect against certain cancer types, but the jury is out as to whether it actually improves outcomes after diagnosis."
  October 2015 ,Medscape Medical News,Supplements Tied to 23K Emergency Department Visits Annually,"Lightly regulated dietary supplements send 23,005 Americans to emergency departments each year, with young patients likely to suffer cardiac woes and older patients likely to have problems swallowing."
  October 2015 ,Medscape Medical News,Impact of START Trial Center Stage at European AIDS Meeting,New results on antiretroviral therapy and the fight against AIDS and other infectious diseases in Europe will be highlights of the meeting.
  October 2015 ,Medscape Medical News,Old Drug Has New Promise in MS," Minocycline, an antibiotic that has been around for decades, reduced the risk for progression from clinically isolated syndrome to definite multiple sclerosis in a new study."
  October 2015 ,Medscape Medical News,Stimulants Safe in Children With ADHD and Heart Disease,Stimulant medications for the treatment of ADHD in children with congenital heart disease are as safe and effective as they are for children with no underlying heart condition.
  October 2015 ,Medscape Medical News,Fluid Management: Buffered Crystalloid No Benefit vs Saline,"Among patients in the ICU receiving crystalloid fluid therapy, use of a buffered crystalloid compared with saline did not reduce the risk for acute kidney injury in a randomized trial. "
  October 2015 ,Medscape Medical News,Alemtuzumab in MS: Still Looks Good at 5 Years,"New 5-year data from the pivotal phase 3 trials show alemtuzumab (Lemtrada, Genzyme) continues to be associated with low rates of disease progression and brain atrophy in patients with relapsing MS."
  October 2015 ,FDA Approvals,FDA Expands Use of Nivolumab in Lung Cancer,"The new use is in nonsquamous, non-small-cell lung cancer (NSCLC). The drug was approved for squamous NSCLC earlier in the year."
  October 2015 ,Medscape Medical News,Experimental Tardive Dyskinesia Drug Hits Mark in Phase 3,Neurocrine Biosciences' drug NBI-98854 eases symptoms of tardive dyskinesia in a phase 3 study.
  October 2015 ,Medscape Medical News,"Women Are Demanding, and Receiving, Compounded Hormones","The North American Menopause Society offers strict recommendations but little guidance on how to stem the tide, reminding physicians that they are legally bound to prescribe the FDA-approved products."
  October 2015 ,Medscape Medical News,More Data on Daclizumab in MS: DECIDE Published  ,2015 meeting shows more patients had 'no evidence of disease activity' with daclizumab vs beta interferon.
  October 2015 ,Medscape Medical News,Ankle Fracture: No Added Value With Supervised Exercise Rehab,"After ankle fracture, a supervised exercise program does not improve recovery of activity limitation or quality of life compared with advice alone, according to a new randomized trial."
  October 2015 ,Medscape Medical News,Orphan Drug Shown Effective for LEMS Weakness,"The study was designed to finally earn FDA approval for 3,4 DAP, long used to treat Lambert-Eaton myasthenic syndrome on a compassionate basis."
  October 2015 ,FDA Approvals,FDA Expands Indication for Optune Device in Glioblastoma,The FDA has expanded the indication for the Optune device so it can be used as adjunct therapy in newly diagnosed patients with glioblastoma multiforme.
  October 2015 ,Medscape Medical News,Psoriatic Arthritis: Phase 3 Data Confirm Secukinumab Efficacy,The FUTURE 1 trial has confirmed that selective inhibition of IL-17A improves signs and symptoms of psoriatic arthritis for 1 year.
  October 2015 ,Medscape Medical News,Thyroid Hormone Common Contaminant in Weight-Loss Supplements,"A sampling of the most popular over-the-counter weight-loss supplements shows a third contain thyroid hormone, some at alarming levels."
  October 2015 ,Medscape Medical News,HPV Vaccination Rates Low Among Adolescent Males ,"Human papilloma virus vaccination rates in adolescent males have increased in recent years, but remain very low, a new study has showed."
  October 2015 ,Medscape Medical News,FDA Panel Backs Lesinurad (Zurampic) for Gout,"An FDA advisory committee recommended approval of lesinurad for the treatment of gout-associated hyperuricemia, in combination with a xanthine oxidase inhibitor."
  October 2015 ,News Alerts,New EMA Advice on PML Prevention With Tecfidera in MS,"The European Medicines Agency today issued recommendations on ways to minimize the risk for PML with dimethyl fumarate (Tecfidera), as well as with Fumaderm and Psorinovo, fumarates used in psoriasis.    "
  October 2015 ,Medscape Medical News,Pervasive Environmental Toxin Linked to Pregnancy Loss,A new study suggests a link between biochemical pregnancy loss in women using in vitro fertilization or intrauterine insemination who have high levels of phthalates in their urine.
  October 2015 ,Medscape Medical News,Shorter RT Convenient Option for Low-Risk Prostate Cancer,"A shorter radiation schedule provides disease-free survival rates similar to those of conventional radiation, and it is more convenient than the more traditional approach."
  October 2015 ,FDA Approvals,FDA Approves Trabectedin for Two Soft Tissue Sarcomas,"Researchers saw no improvement in overall survival in the pivotal US trial, but there are explanations for that."
  October 2015 ,News Alerts,"Viekira Pak, Technivie May Up Serious Liver Injury Risk: FDA","The hepatitis C infection treatments Viekira Pak and Technivie may increase the risk for serious injury, particularly in those with underlying liver disease, the FDA warns."
  October 2015 ,Reuters Health Information,FDA Approves Relypsa's Drug Veltassa to Treat Hyperkalemia,The U.S. Food and Drug Administration approved Relypsa Inc's drug Veltassa (patiromer for oral suspension) to treat hyperkalemia in patients with chronic kidney disease or heart problems.
  October 2015 ,WebMD Health News,New Clues Why ‘Pear-Shaped' Women Less Likely to get Diabetes,A study found variants determine where body fat is stored and the regulation of fat cells.
  October 2015 ,Medscape Medical News,"Approved But Not Proven: What's Up With FDA, Cancer Drugs?",How many approved cancer drugs actually pan out in terms of a survival benefit?
  October 2015 ,Medscape Medical News,Dual Therapy No Better Than NSAIDs Alone for Low Back Pain ,"In patients with acute nontraumatic lower back pain, adding cyclobenzaprine or oxycodone/acetaminophen to naproxen alone did not improve functional outcomes or pain at 1 week."
  October 2015 ,Medscape Medical News,NCCN Unveils New 'Evidence Blocks' Initiative,The NCCN has developed a novel system that will make it easier for the provider and patient to make informed choices when selecting systemic therapies. 
  October 2015 ,FDA Approvals,FDA Approves Oral Potassium-Binder Patiromer (Veltassa),"It's been shown in trials to safely normalize serum potassium levels in patients taking drugs known to raise potassium, including aldosterone blockers and ACE inhibitors."
  October 2015 ,Medscape Medical News,High Maternal Thyroid Function Affects Offspring Brain Development,"The study is the first to show a link between high maternal thyroid function, as well as low, and neurodevelopment of offspring in childhood as assessed by     IQ and MRI brain scanning."
  October 2015 ,Medscape Medical News,Partial as Good as Whole-Breast Irradiation -- Clear Result,A technique of temporary implanting of catheters to deliver radiotherapy for 4 to 5 days was as effective as whole-breast irradiation for 5 weeks.
  October 2015 ,Medscape Medical News,Concerns Over Sudden Increase in Radiation for Skin Cancer,"The use of first-line electronic brachytherapy for nonmelanoma skin cancer has risen 20-fold, raising concerns over inappropriate use."
  October 2015 ,Medscape Medical News,Men's Health Supplements Useless in Prostate Cancer Patients,Men's health supplements marketed to promote prostate health have absolutely no benefit on outcomes or toxicities in men undergoing radiation therapy for prostate cancer.
  October 2015 ,Medscape Medical News,Steroid Reduces Flare After Radiation for Bone Metastases,"A few doses of steroid reduces the risk for and severity of pain flares that can occur immediately after radiation therapy, before the pain starts to recede."
  October 2015 ,Medscape Medical News,Green Light for Less Therapy for HPV Oropharyngeal Cancer,Mounting evidence suggests that deintensification is feasible and that it reduces toxicity without compromising survival.
  November 2015 ,Medscape Medical News,FDA Panel Says Fluoroquinolones Need Stronger Warnings,"Fluoroquinolone labels need much stronger warnings about the risks for serious adverse events, according to members of two FDA committees."
  November 2015 ,Medscape Medical News,Transcranial Stimulation May Quell Cravings in Obese Subjects," Stimulating the prefrontal cortex may alter food-reward circuits in the brain, diminish cravings, and lead to weight loss, a small proof-of-principle trial     suggests."
  November 2015 ,FDA Approvals,FDA Clears New Combo Pill Genvoya for HIV-1 Infection,"Genvoya combines elvitegravir, cobicistat, emtricitabine, and a new form of tenofovir, which appears to have a better safety profile than tenofovir disoproxil fumarate. "
  November 2015 ,Medscape Medical News,NEPA Added to ASCO Guildelines on Antiemetic Use,The new combination product of netupitant and palonosetron (known as NEPA) has been included in an expedited update of antiemetic guidelines.
  November 2015 ,Medscape Medical News,Europe Concludes Syndromes Are Not Caused by HPV Vaccine,"The European Medicines Agency has concluded its safety review of the HPV vaccines, and says the evidence does not support causation of syndromes."
  November 2015 ,Medscape Medical News,First Precision Medicine Chemoprevention Trial Disappoints,"In the first precision-based chemoprevention study, erlotinib failed to significantly prevent the development of oral cancer in patients with oral premalignant lesions."
  November 2015 ,FDA Approvals,FDA Approves Mepolizumab (Nucala) for Severe Asthma,"The FDA has approved mepolizumab (Nucala, GlaxoSmithKline) in combination with other asthma medications for maintenance treatment of patients aged 12 years or older with severe asthma."
  November 2015 ,Kaiser Health News,Researchers Say Path to Better Health Starts With Patients' Input,"The Patient-Centered Outcomes Research Institute, which has funded 468 studies, is creating research networks that will cover specific diseases involving millions of patients across the country."
  November 2015 ,Medscape Medical News,More Positive Results With Cannabidiol in Epilepsy,"Six-month data on an investigational cannabidiol product in children with intractable epilepsy are encouraging, investigators say."
  November 2015 ,Reuters Health Information,IBD Patients May Accept Riskier Drugs to Get Durable Remissions,"Patients with inflammatory bowel disease may be willing to accept as much as a 28% risk of a serious infection and a 1.8% chance of developing lymphoma with a newer, more effective therapy than currently exists, a new study suggests."
  November 2015 ,Medscape Medical News,T3 Analog Triac Improves Allan-Herndon-Dudley Syndrome," Triac, a T3 analog, has been shown to significantly boost T3 levels in patients with Allan-Herndon-Dudley syndrome, a rare genetic disorder characterized     by intellectual disability and movement problems."
  November 2015 ,Medscape Medical News,"Biosimilars, Tech Advances, Chikungunya Among ACR Highlights","More than 16,000 attendees at the American College of Rheumatology (ACR) meeting will hear about the latest technology and resources to make their practices more efficient."
  October 2015 ,Medscape Medical News,Meds Seldom Deintensified in Elderly Diabetics: VA Study," ""We found that only one in four of nearly 400,000 older patients who could have been eligible to ease up on their multiple BP or blood sugar medicines     actually had their dosage changed."""
  October 2015 ,Medscape Medical News,Experts Disagree Over Focal Therapy for Prostate Cancer,Arguments over focal therapy for prostate cancer assume greater urgency following the FDA's approval of a device for focal prostate tissue ablation.
  October 2015 ,Medscape Medical News,"Low-dose Ketamine Eases Pain, Reduces Opioid Use in ED","Studies have already shown an analgesic benefit for the sedative at higher doses, but with more serious adverse events, investigators say."
  October 2015 ,Medscape Medical News, Iodine May Be Safer Alternative for Graves' Disease in Pregnancy,"A Japanese study ""suggests that the view that we have about iodine being dangerous to the hyperthyroid person and to the fetus may need to be revised,""     says an expert observer."
  October 2015 ,Medscape Medical News,Experimental Agent Shows Promise for Alcohol Dependence,The compound OSU6162 reduces 'liking' and craving for alcohol in alcohol-dependent adults by normalizing dopamine levels in the brain.
  October 2015 ,FDA Approvals,FDA Approves Ipilimumab (Yervoy) for Use in Stage III Melanoma ,"Ipilimumab is now approved for use as an adjuvant therapy for patients with resectable melanoma that has spread to the lymph nodes, the agency announced today.  "
  October 2015 ,FDA Approvals,"FDA Approves Imlygic, First Oncolytic Viral Therapy in the US","The FDA has given the green light to talimogene laherparepvec for the treatment of advanced melanoma, making it the first oncolytic viral therapy to be approved for sale in the United States. "
  October 2015 ,News Alerts,FDA Review Finds No Increased CV Risk With Entacapone in PD,An FDA review has found no increased cardiovascular risk linked to use of entacapone in the treatment of Parkinson’s disease. 
  November 2015 ,Medscape Medical News,"Brazil Study: Gastric Balloon Valid Option, but Outcomes Not Durable","In this multicenter study of more than 3000 people, excess weight loss was greater in less obese patients, and there was only one gastric perforation, but     weight loss didn't last, despite multidisciplinary support."
  November 2015 ,Medscape Medical News,Rituximab Emerging as New Option for Membranous Nephropathy,"The treatment of membranous nephropathy remains controversial, but new data suggest that adding rituximab to nonimmunosuppresive antiproteinuric therapy is an option."
  November 2015 ,Medscape Medical News,Viekira Pak Results Reassuring for Compensated Cirrhosis,"For patients with genotype 1 hepatitis C infection and cirrhosis, the combination of ombitasvir, paritaprevir, and ritonavir plus dasabuvir, with or without ribavirin, is safe and effective."
  November 2015 ,Heartwire from Medscape,"Empagliflozin's CV Gains Explored in Diabetics With, Without HF","Given the specter of associated heart failure with some antidiabetic medications, deeper analysis of the recently reported EMPA-REG OUTCOME trial of the SGLT2 inhibitor may reassure. "
  November 2015 ,FDA Approvals,Daratumumab Approved for Multiple Myeloma in US,"The first monoclonal antibody for use in multiple myeloma, daratumumab (Darzalex), has just been approved by the FDA."
  November 2015 ,Medscape Medical News,Clozapine Best Choice for Treatment-Resistant Schizophrenia,"Treatment-resistant schizophrenia patients have better outcomes with clozapine compared with other standard antipsychotics, but despite its superior efficacy, the drug remains vastly underutilized."
  November 2015 ,Medscape Medical News,Filgotinib Shows Potential in Rheumatoid Arthritis,"Response to the Janus kinase 1 inhibitor was good in patients with rheumatoid arthritis who have highly active disease despite methotrexate therapy, new research showed."
  November 2015 ,Medscape Medical News,Chronic Symptoms After HPV Vaccination: Danes Start Study,Danish specialists are investigating more than 1300 girls with chronic symptoms after HPV vaccination.
  November 2015 ,Heartwire from Medscape,Candesartan May Cut Cardiotoxicity in Breast Cancer Patients,"Adjuvant candesartan (but not metoprolol) showed ""significant but modest"" attenuation of LVEF changes after cancer therapy. More research is needed, but     ""this study is a key first step,"" notes one expert."
  November 2015 ,Medscape Medical News,Deeper Grasp of Chemotherapy-Induced Peripheral Neuropathy,Two unrelated studies provide deeper insights into chemotherapy-induced peripheral neuropathy.
  November 2015 ,Medscape Medical News,Big Trials Disappoint at Kidney Week,"The mystifying relation between vascular complications and kidney disorders has investigators stumped after negative results from three highly anticipated trials of statins, steroids, and fish oils."
  November 2015 ,Medscape Medical News,Gastric-Balloon 'Pill' Shows Early Promise in Weight Loss," This novel gastric balloon is swallowed and later excreted, without the need for endoscopy and anesthesia; however, this is an experimental device in early     stages of research."
  November 2015 ,Medscape Medical News,Perioperative Medication Errors Plague Surgeries ,"Previous literature on perioperative medication error rates underestimated true error rates, according to a new prospective study. "
  November 2015 ,FDA Approvals,FDA Approves Cotellic as Part of Melanoma Combination,"The MEK inhibitor cobimetinib (Cotellic, Roche) works with already-approved vemurafenib for the treatment of advanced melanoma that is BRAF mutation-positive."
  November 2015 ,Medscape Medical News,RA: No 'Sound Evidence' to Support Use of Cannabinoids,"Available studies do not support the use of medical marijuana in rheumatic disorders, although there is merit to further research, authors of a  systematic review concluded."
  November 2015 ,Medscape Medical News,"Bariatric Surgery May Aid Very Obese Teens, 3-Year Data Show"," In the longest-ever prospective study of very obese teens who had gastric bypass or sleeve gastrectomy, the teens maintained a weight loss of 28% at 3     years, with manageable side effects."
  November 2015 ,Heartwire from Medscape,Varenicline Started in ACS Hospitalization Helps Smokers Quit,"UPDATED // In a randomized trial, a rare successful showing for a smoking-cessation medication in this particularly sick population, abstinence at 24 weeks was     confirmed by carbon-monoxide breath analysis."
  November 2015 ,Medscape Medical News,NY Docs Must Complete 4-Hour CME to Prescribe Marijuana,Advocates said that the cost and time of the required course will dampen enthusiasm. 
  November 2015 ,Medscape Medical News,Adverse Reaction to Aspirin Often Misdiagnosed as Allergy ,"Many physicians erroneously label adverse reactions to aspirin as allergic, depriving cardiology patients of access to cost-effective therapy."
  November 2015 ,Heartwire from Medscape,NEAT-HFpEF: Activity Levels Fall on Nitrates in Preserved-EF HF,There wasn't much neat about treatment with isosorbide mononitrate in the small randomized trial; it didn't improve functional capacity or quality-of-life     measures and may even have harmed.
  November 2015 ,FDA Approvals,FDA Approves Nivolumab for Renal Cell Carcinoma,The immunotherapy is the first treatment to show a survival benefit as a second-line therapy in patients with advanced disease.
  November 2015 ,Medscape Medical News,New Strategies but Modest Benefit in Uveal Melanoma,"New therapies being tried in uveual melanoma include combination everolimus, pasireotide long-acting release, and the MEK inhibitor trametinib."
  November 2015 ,International Approvals,EMA Panel Backs Episalvan for Partial-Thickness Wounds,"Made from birch bark extract, Episalvan can reduce the healing time of wounds in which the upper layers of the skin have been damaged, for example by a burn or during surgical skin grafting. "
  November 2015 ,Medscape Medical News,"New Dry Eye Gel Improves Some, but Not All, Symptoms",A carbomer-based lipid-containing artificial tear formulation improved patients' ocular surface staining grades and ocular irritation symptom scores and decreased symptoms in patients with dry eye.
  November 2015 ,Heartwire from Medscape,No Ranolazine Benefit Against Angina Seen in Small-Vessel CAD,"The antianginal agent didn't overall reduce symptoms due to microvascular disease in the small trial, although it may have helped in patients with the poorest coronary flow reserve."
  November 2015 ,International Approvals,CHMP Recommends EU Approval for Brivaracetam ,"The Committee for Medicinal Products for Human Use recommends marketing approval for brivaracetam (Briviact, UCB Pharma SA) as adjunctive therapy for partial-onset seizures."
  November 2015 ,Medscape Medical News,"Europe Again Says HPV Vax Safe,  but Petition in Spain","Europe has again said that HPV vaccination is safe and that it is not causally linked to chronic syndromes, but some doctors remain unconvinced."
  November 2015 ,FDA Approvals,"FDA Okays Ixazomib, Another Multiple Myeloma Drug",This is the third approval this year for the treatment of the blood cancer.
  November 2015 ,International Approvals,EMA Recommends Approval of Pitolisant (Wakix) for Narcolepsy ,Pitolisant is a first-in-class drug that increases histamine release in the brain to enhance wakefulness and alertness.
  November 2015 ,Heartwire from Medscape,Myosin-Activating Heart-Failure Med Advances in Small Trial,"Omecamtiv mecarbil in oral form seemed to improve ventricular function, dimensions, and volumes, and in general appeared safe despite one disagreeable,     eyebrow-raising biomarker signal."
  November 2015 ,Medscape Medical News,Sustained-Release Bimatoprost Lowers Intraocular Pressure,"The reduction in intraocular pressure was significant in glaucoma patients treated with the bimatoprost implant, 6-month results from the 24-month study suggest."
  November 2015 ,Reuters Health Information,Canadian Dermatologists Issue New Acne Treatment Guidelines,"Canadian researchers have published evidence-based guidelines to aid in treating acne, which affects up to 85% of adolescents and young adults."
  November 2015 ,Heartwire from Medscape,SPRINT and BP Management: 'Groundbreaking' but Questions Remain,"""If I had a patient with characteristics of SPRINT and they could tolerate the medication and were willing to go through more steps of titration, I'd want to try to get them to 120,"" said one expert."
  November 2015 ,Medscape Medical News,tPA for Stroke: Reassuring Results for Patients on Antiplatelets,A new study representing the largest clinical experience of thrombolysis for stroke in patients receiving antiplatelet therapy suggests the overall benefits may outweigh the risks in this population.
  November 2015 ,Medscape Medical News,Early Azithromycin Reduces Severe Respiratory Tract Infections,"Children with recurrent wheeze who received azithromycin at the start of each respiratory tract infection were less likely to need oral corticosteroids later, a randomized trial showed."
  November 2015 ,Medscape Medical News,Anaphylaxis Risk Highest With IV Iron Dextran,"For patients receiving a first dose of an intravenous iron product, iron dextran had more than three times the risk for anaphylaxis as did iron sucrose."
  November 2015 ,Medscape Medical News,New Approach to Fibromyalgia Tackles Poor-Quality Sleep,"For patients with fibromyalgia, improving the quality of sleep can help improve other features of the syndrome, including pain, new analyses show."
  November 2015 ,Heartwire from Medscape,"Dyspnea, Minor Bleeds Led Causes for Stopping Ticagrelor in Trial","  ""As clinicians we shouldn't underestimate the impact on patients of nosebleeds and bruising,"" said a PEGASUS TIMI 54 researcher, so before treatment patients should hear about even nonmajor risks. "
  November 2015 ,WebMD Health News,What Charlie Sheen's Reveal Means for HIV,Charlie Sheen reveals he is HIV positive. 
  November 2015 ,Medscape Medical News,Acute Kidney Injury Linked to BRAF Inhibitors in Melanoma,"Treatment with vemurafenib and dabrafenib was associated with acute renal toxicity in patients with melanoma, according to data from the FDA Adverse Event Reporting System."
  December 2015 ,News Alerts,FDA Adds Warnings to SGLT2 Inhibitors,The FDA has updated warnings in the labels for SGLT2 inhibitors to include the risks for ketoacidosis and severe urinary tract infections. 
  December 2015 ,Medscape Medical News,New Survivorship Care Plan Template for Radiation Oncology,"A comprehensive American Society of Radiation template, intended for specialists and primary care clinicians, aims to standardize and streamline post-treatment care."
  December 2015 ,Medscape Medical News,Metformin Doesn't Improve HbA1c in Kids with Type 1 Diabetes,Adding metformin to insulin did not improve glycemic control in obese and overweight adolescents with type 1 diabetes but did lead to a reduction in     insulin dose and some weight loss.
  December 2015 ,Medscape Medical News,Fewer Labs OK for Patients Treated With Isotretinoin for Acne,"Minimal laboratory monitoring early in the course of isotretinoin therapy in patients with acne may be sufficient, according to a new study."
  December 2015 ,International Approvals,EMA OKs Nucala for Severe Refractory Eosinophilic Asthma,The European Medicines Agency has approved mepolizumab as an add-on treatment for severe refractory eosinophilic asthma in adults.
  December 2015 ,Reuters Health Information,Zafgen Says Second Patient Dies in Obesity Drug Trial,"A second patient died in a late-stage trial of Zafgen Inc's experimental obesity treatment, beloranib."
  December 2015 ,Medscape Medical News,Novel Depression Drug Hits Regulatory Roadblock,An FDA advisory committee determined that the evidence backing gepirone does not support its approval as a treatment for major depression.
  December 2015 ,Medscape Medical News,ELIXA Published: Reiterates CV Safety of Lixisenatide in Diabetes,Genotyping of the 5-fluorouracil (5-FU) detoxifying enzyme dihydropyrimidine dehydrogenase may provide guidance on 5-FU dosing and improve safety for cancer patients prescribed 5-FU.
  December 2015 ,Medscape Medical News,Up-front Genotyping Reduces Fluoropyrimidine Toxicity,"The federal report estimates that 12 of every 100 hospital stays included an infection or other avoidable complication in 2014, about the same rate as 2013. Still, that was 17 lower than 2010."
  December 2015 ,Kaiser Health News,Hospital Injury Rates Plateau After 3 Years of Decline,"The UK drug watchdog NICE has finally issued its new guidelines for the treatment of type 2 diabetes in adults, but there is still some criticism from     diabetes specialists and organizations."
  December 2015 ,Medscape Medical News,UK NICE Backtracks on Some of its Type 2 Diabetes Guidance,Glycerol phenylbutyrate (Ravicti) is for patients with urea cycle disorder who cannot be managed by dietary protein restriction and/or amino acid supplementation alone.
  December 2015 ,International Approvals,Europe Clears Ravicti for Urea Cycle Disorders,"The relative risks are ""substantial"" but the absolute risks should be seen in perspective, say researchers. ""After almost 20 years of follow-up, the majority of the women were still alive."""
  December 2015 ,Heartwire from Medscape,"Re-MI, Re-Stroke Risks Defined in Women on Oral Contraceptives",A second monoclonal antibody for use in the treatment of multiple myeloma has been approved by the FDA within 2 weeks of approval of the first such product.
  November 2015 ,FDA Approvals,Elotuzumab (Empliciti) Approved for Multiple Myeloma in US,"FDA reviewers and advisory committee panel members were critical of drisapersen data, suggesting they may not provide the evidence needed for approval for Duchenne muscular dystrophy."
  November 2015 ,Medscape Medical News,FDA Panel Critical of Drisapersen Data in Duchenne,Diabetes thought leaders' input was used to develop a formula for weighing the various factors that inform appropriate glycemic-control targets for         individual patients with type 2 diabetes.
  November 2015 ,Medscape Medical News,Algorithm Helps Individualize HbA1c Targets in Type 2 Diabetes,US experts have developed new guidelines for general inpatient psychiatric care for children with autism or intellectual disabilities to bring it in line with care provided in specialist units.
  November 2015 ,Medscape Medical News,New Guidelines to Improve Inpatient Care for Kids With Autism,A comprehensive review reveals there is very low-quality evidence to support the use of methylphenidate i
  November 2015 ,Medscape Medical News,Experts Urge Caution When Prescribing Common ADHD Drug in Kids,"The novel product, a monoclonal antibody against EGFR, is approved for use with chemotherapy in patients with squamous non-small cell lung cancer (NSCLC)."
  November 2015 ,News Alerts,Necitumumab (Portrazza) Approved for Lung Cancer in US,"A meta-analysis has found that medications impair sleep latency, efficiency, and duration, and suggested skipping a third daily dose."
  December 2015 ,Medscape Medical News,IBD: Skin Issues From Anti-TNF Therapy Should Be Addressed,Most patients who developed skin lesions during anti-TNF therapy for IBD who saw a dermatologist continued treatment.
  December 2015 ,Medscape Medical News,FDA Panel Backs Reslizumab for Adults With Severe Asthma ,"The advisory committee ruled that evidence wasn't strong enough for recommending the drug for children aged 12 to 17 years, citing small numbers in studies; concerns include risk for anaphylaxis and muscle toxicity."
  December 2015 ,Medscape Medical News,"Depression Outcomes Similar With Antidepressants, CBT",A meta-analysis shows second-generation antidepressants and cognitive- behavioral therapy produce equal response and remission rates and surprisingly similar withdrawal rates in major depression.
  December 2015 ,News Alerts,FDA Warns of Contamination Risk for Some Baclofen API Lots,"Certain lots of baclofen active pharmaceutical ingredient (API) may be at risk for contamination with particulates and should not be used to compound sterile injectable drugs, the FDA warns."
  December 2015 ,Medscape Medical News,Cannabidiol Effective and Safe at 3 Months for Epilepsy,"New open-label data on purified cannabidiol in children and young adults with treatment-resistant epilepsy are 'promising' at 3 months' follow-up, researchers say. "
  December 2015 ,Medscape Medical News,No Effect on HbA1c for Liraglutide + Insulin in Type 1 Diabetes ,"  A Danish study showed no effect on HbA1c for liraglutide added to insulin in overweight adults with type 1 diabetes; therefore, its use can't currently be     recommended, says lead author."
  December 2015 ,Medscape Medical News,Ophthalmologists Have Low Patient Complaint Rates,"Ophthalmologists at academic centers have the highest risk for patient complaints compared with others in their field, but ophthalmology overall enjoys fewer complaints than other medical specialties."
  December 2015 ,Medscape Medical News,Some Differences Between Once-Weekly GLP-1 Agonists," Once-weekly GLP-1 receptor agonists dulaglutide, exenatide, and the now-withdrawn taspoglutide show the greatest reduction of HbA1c in a meta-analysis.     Hypoglycemia risk is similar across the class."
  December 2015 ,Heartwire from Medscape,"'Bad Press' May Make Patients Stop Statins, Raise MI Risk","An increased event risk is the ""most disturbing"" aspect of the analysis, says one expert: ""Major media outlets need to be more careful about how they cover stories generated by antistatin zealots."""
  December 2015 ,Medscape Medical News,Idelalisib Trial Stopped Because of 'Overwhelming Efficacy',"In chronic lymphocytic leukemia, idelalisib combined with bendamustine and rituximab improved progression-free and overall survival compared with the standard two-drug combination."
  December 2015 ,Medscape Medical News,Infant Weight Gain in First Year: Link to Type 1 Diabetes Risk ,An author says the findings offer one more clue about risk but should not lead to changes in feeding.
  December 2015 ,Medscape Medical News,Women at Risk for Breast Cancer Don't Take Preventive Drugs ,"Most women who are at high risk for breast cancer are choosing not to take drugs that could prevent the disease, a meta-analysis reveals.   "
  December 2015 ,FDA Approvals,Cold Cap to Prevent Hair Loss During Chemo Cleared in US ,"For the first time in the United States, women with breast cancer undergoing chemotherapy can wear a cold cap to reduce the risk for hair loss.  "
  December 2015 ,FDA Approvals,FDA OKs First Drug (Kanuma) for Rare Enzyme Disease,"Produced with the help of genetically engineered chickens, the drug treats adults and children with lysosomal acid lipase deficiency, a potentially life-threatening genetic disorder."
  December 2015 ,Medscape Medical News,Ixazomib in First Oral Triplet for Multiple Myeloma,Data from the trial that led to the approval of ixazomib have been presented for the first time. This is the first oral triplet for myeloma.
  December 2015 ,Medscape Medical News,Third Trimester Antibiotic Use Ups Risk for Childhood Wheeze,"Excess risk for childhood wheezing with antibiotic exposure during the third trimester remains after adjustment for confounding factors; for example, maternal respiratory infections during pregnancy."
  December 2015 ,Medscape Medical News,Autoimmune Epilepsy Gaining Attention,"Researchers are learning more about antibodies that attack the brain, causing various seizure syndromes."
  December 2015 ,Medscape Medical News,More Evidence Needed for Women's Health Preventive Services, The US Preventive Services Task Force and the Endocrine Society are calling on Congress to provide funding to address key evidence gaps in preventive     services for women's health.
  December 2015 ,Medscape Medical News,Little Sign of Higher Kidney Risk With Long-term Lithium,"Researchers find no increase in kidney function decline with long-term lithium maintenance over other drugs in affective disorder patients with good baseline function, a finding they call 'reassuring.' "
  December 2015 ,Reuters Health Information,New Tool Measures Patient Satisfaction After Rhinoplasty,A new module can help patients tell plastic surgeons how they feel about their nose before and after rhinoplasty.
  December 2015 ,Medscape Medical News,Isavuconazole Comparable to Voriconazole for Aspergillosis Treatment ,Benefits of the broad-spectrum antifungal in a phase 3 trial included fewer adverse effects and improved ease of use.
  December 2015 ,Medscape Medical News,Fourth PML Case With Tecfidera in MS Calls for Vigilance," After a fourth case of PML linked to the MS drug dimethyl fumarate (Tecfidera), it's becoming more widely accepted that even 'safer' immunosuppressants may have dangerous adverse effects, experts say."
  December 2015 ,Heartwire from Medscape,Resuming Antithrombotics for AF Safe After a Halt for GI Bleed,"More evidence is called for, caution researchers, but after patients recover from the bleed, ""restarting or modifying"" antithrombotics to a single agent seems safe and improves outcomes, say researchers."
  December 2015 ,Medscape Medical News,Antidepressants Linked to Increased Mania Risk,"SSRIs, venlafaxine linked to higher risk for manic or bipolar episodes, but role of underlying bipolar disorder a suspected factor."
  December 2015 ,Medscape Medical News,Appetite-Regulating Hormones May Block Alcohol Cravings,"Appetite hormones leptin and ghrelin have inverse appetitive effects, and the relationship between them could be harnessed to reduce cravings for alcohol in patients with alcohol use disorder."
  December 2015 ,Medscape Medical News,The Vicious 'Sleep-Seizure' Cycle in Epilepsy,Researchers are making headway in pinpointing factors involved in the interaction between sleep and epilepsy. 
  December 2015 ,Medscape Medical News,Switch From LMWH to Warfarin OK in Cancer-Related Thrombosis,"Switching from a low-molecular-weight heparin to warfarin is not associated with an increase in recurrent venous thromboembolism, major bleeding, or total bleeding."
  December 2015 ,Medscape Medical News,"High-Potency Cannabis Linked to Brain Damage, Experts Warn","High-potency cannabis damages the white matter in the corpus callosum independently of psychosis risk, say researchers, who warn of the urgent need to educate healthcare professionals and the public."
  December 2015 ,Medscape Medical News,Happiness Has No Influence on Mortality Risk,"Levels of happiness have no impact on an individual's mortality risk, concludes a detailed study of more than 700,000 women followed for over 10 years."
  December 2015 ,Medscape Medical News,STOP-IgAN Disappoints With No Benefit From Additional Rx,Additional immunosuppression on top of best supportive care does not change outcomes for patients with moderately high-risk IgA nephropathy at the end of 3 years. 
  December 2015 ,Medscape Medical News,Ketamine for Refractory Status Epilepticus?,"Ketamine, used for analgesia and sedation, is increasingly being used to treat refractory status epilepticus, but only for the most critically ill children, a new study suggests."
  December 2015 ,Medscape Medical News,Solidified: TDM-1 in Pretreated Metastatic HER2-+ Patients,The final overall survival results from a major trial of patients with heavily pretreated disease are now in.
  December 2015 ,Reuters Health Information,Targeted Treatment May Reverse Alopecia Areata,"The psoriasis drug ustekinumab can spur hair regrowth and normalize immune function in patients with alopecia areata, according to the results of a study in three patients."
  December 2015 ,Medscape Medical News,Pharmacists Play Key Role in Mitigating Medication Errors,"Human and system errors during code situations are frequent, but pharmacists can have a protective effect."
  December 2015 ,Medscape Medical News,Prevent Addiction in Pediatric IBD Patients at High Risk,Some children and adolescents with inflammatory bowel disease are at higher risk for chronic narcotic use and dependence. Evidence-based clinical strategies for prevention and treatment can help. 
  December 2015 ,Medscape Medical News,"AI vs Tamoxifen for DCIS? A Toss-up, Unless…","Both anastrozole and tamoxifen were effective at preventing recurrence of breast cancer in postmenopausal women with ductal carcinoma in situ. Age, toxicities should drive choice, say investigators."
  December 2015 ,Heartwire from Medscape,Cancers May Impair Heart Function: More Evidence," Treated and nontreated cancer patients had similarly reduced cardiac strain, which may suggest that ""some inflammatory components to the tumor growth     affect the heart muscle,"" say researchers."
  December 2015 ,FDA Approvals,Alectinib Approved in US for Refractory ALK-Positive NSCLC ,"Another ALK-targeted therapy has been approved for use in patients who no longer respond to crizotinib, but this one is also active on brain metastases."
  December 2015 ,FDA Approvals,First Emergency Antidote to 5-FU Chemo in the US,This first-of-its-kind product is an emergency antidote for use in cases of unintended overdose or severe adverse reaction to 5-fluorouracil (5-FU).
  December 2015 ,Heartwire from Medscape,Three-Year Major Bleeding Risk Same With Watchman or Warfarin,"Patients with AF face a similar 3-year bleeding risk if they undergo left atrial appendage closure with this device or stay on long-term warfarin therapy.     The CMS cautionary approach is right, two experts say."
  December 2015 ,Medscape Medical News,Medicare's NTAP for Blinatumomab Should Be Questioned,"The NTAP program was designed to help hospitals offset costs associated with innovative interventions, but a new expensive drug does not meet the criteria, say two experts."
  December 2015 ,Medscape Medical News,Secukinumab Effective for Ankylosing Spondylitis in Phase 3 Trials ,"A 150-mg subcutaneous monthly secukinumab dose achieved the best results, but there was no added benefit from an intravenous loading dose in ankylosing spondylitis, according to interim phase 3 data. "
  December 2015 ,Medscape Medical News,Surgical Castration Instead of Drugs in Prostate Cancer,"Surgical castration has a lower risk for fractures, peripheral arterial disease, thromboembolism, and cardiac complications than GnRH agonists in metastatic prostate cancer."
  December 2015 ,Medscape Medical News,LIRA-RENAL: Liraglutide Safe in Diabetes With Renal Failure,Data from the LIRA-RENAL study detailing use of liraglutide in patients with type 2 diabetes and moderate kidney disease have been published.
  December 2015 ,Medscape Medical News,Misperceptions Drive Pot Use Among Patients With Glaucoma,"Patients with glaucoma are more likely to use marijuana for treatment if they believe it is safe and effective, according to a new study."
  December 2015 ,Medscape Medical News,Pembrolizumab Now Approved for First Line in Melanoma ,The cell programmed-death inhibitor pembrolizumab was more effective and less toxic in first-line treatment when compared with ipilimumab.
  December 2015 ,Medscape Medical News,Common Skin Problems With EGFR-TKIs Used for Lung Cancer,"In patients treated with EGFR-TKIs for lung cancer, the most common skin problems are acne-like lesions, itching, dry skin, and nail bed inflammation."
  December 2015 ,FDA Approvals,FDA Clears Selexipag for Pulmonary Arterial Hypertension,The oral IP prostacyclin receptor agonist is indicated to delay disease progression and reduce the risk for hospitalization in adults with PAH.
  December 2015 ,Medscape Medical News,"Quiz: New Rheumatology Guidelines, Names, Warnings in 2015","With 2015 coming to a close, here is a chance to look back and see how well you remember the news from this year. Our most popular stories in rheumatology included policy news, as well as drug approvals, drug warnings, and even a new name for a common illness. "
  December 2015 ,Medscape Medical News,Infectious Disease News in 2015: How Much Do You Remember?,"There was a lot happening in the field of infectious diseases this year, from the increasing threat of antibiotic resistance, to the expansion of diseases that used to be rare in the United States, to a major study that changed the way HIV will be treated. Take the following quiz to see how well you followed the news this year."
  December 2015 ,Medscape Medical News,News Quiz: Diabetes and Endocrinology Hot Topics in 2015 ,"It has been an eventful year in the field of diabetes and endocrinology, culminating in the landmark results of the EMPA-REG trial in a group type 2 diabetes patients with coexisting cardiovascular disease. Medscape has charted all of these advances; see how well you remember what happened in 2015."
  December 2015 ,Medscape Medical News,Psychiatry 2015 News Quiz: Test Your Smarts ,Got a nose for news? Test your knowledge of the top news in psychiatry this year. 
  December 2015 ,Heartwire from Medscape,Radial-Access Rare in STEMI Post-Lytic 'Rescue' PCI: NCDR ,"""Transradial rates are still surprisingly low for a population that you would expect to be at high risk for bleeding,"" say researchers, who attribute the finding to the ""risk-treatment"" paradox. "
  December 2015 ,Medscape Medical News,Delayed Prescriptions Can Reduce Antibiotic Overuse ,"In adults with uncomplicated respiratory tract infections, delayed prescription strategies markedly reduced antibiotic use in a randomized controlled trial."
  December 2015 ,Heartwire from Medscape,More Kidney Disease With Long-Term Statins Seen in Cohort Study,"""Clinicians should tell their patients that there may be statin side effects we are not aware of, but there are also benefits that we are aware of,"" say researchers; cause-and-effect were not shown in their study."
  December 2015 ,Reuters Health Information,Proton Pump Inhibitors Affect Gut Bacteria,"Proton pump inhibitors (PPI) used to reduce stomach acid and treat acid reflux change the populations of microbes living in the intestines, which may help explain why they increase the risk of certain infections, according to a new study."
  December 2015 ,International Approvals,EMA Panel Backs Two Octocog Alfa Products for Hemophilia A ,Iblias and Kovaltry from Bayer Pharma AG are indicated for treatment and prevention of bleeding in patients with hemophilia A. 
  December 2015 ,International Approvals,CHMP Recommends Lesinurad (Zurampic) for Gout,The European Medicines Agency panel has recommended marketing authorization for lesinurad for the treatment of hyperuricemia in adults with gout. 
  December 2015 ,International Approvals,CHMP Backs Ferric Maltol for Iron Deficiency Anemia in IBD,Ferric maltol is an oral trivalent iron preparation that increases hemoglobin levels in patients with IBD with iron deficiency anemia. 
  December 2015 ,International Approvals,EU Thumbs Up for Osimertinib and Necitumumab for NSCLC,European Medicines Agency has recommended approval of two new agents that are used in patients with non-small-cell lung cancer (NSCLC) that is EGFR-positive.
  January 2016 ,Medscape Medical News,New PAI Guidelines Stress Importance of Treating Adrenal Crisis,The first-ever Endocrine Society clinical-practice guidelines on diagnosis and management of primary adrenal insufficiency in adults and children stress     the urgency of treating adrenal crisis.
  January 2016 ,Medscape Medical News,Short-Course Corticosteroid Adverse Events Common in Kids ,A systematic review has quantified the risks for adverse events for children taking short courses of oral corticosteroids.
  January 2016 ,Reuters Health Information,QI Cuts Duration of Antibiotics for Uncomplicated SSTIs,"A four-part quality improvement (QI) initiative significantly reduces the duration of antibiotics prescribed for uncomplicated skin and soft tissue infections (SSTIs) in children, researchers report."
  January 2016 ,Medscape Medical News,"CDC, ACP Issue Guideline on Antibiotic Use for RTIs","'Providers should apply strict criteria…to determine when antibiotics are needed,' a guideline author said. "
  January 2016 ,News Alerts,Class I Recall of Cranial Image-Guided Surgery System ,"Brainlab is recalling the system because of navigation inaccuracies that could lead to serious injuries, even death, the FDA said."
  January 2016 ,Medscape Medical News,AACE Publishes Latest 'Cookbook' for Diabetes Management,The new document and set of graphics include all medications licensed in the US through 2015 and incorporates new clinical-trial data.
  January 2016 ,Heartwire from Medscape,Wider Eligibility for Heart Transplantation in New Guidelines,"The ISHLT's 10-year guidelines overhaul relaxes restrictions on weight, age, comorbidities, and other criteria and make a broader-than-ever range of patients eligible for wait listing."
  January 2016 ,Medscape Medical News,'Bipolar' Therapy: New Twist in Advanced Prostate Cancer,"Challenging current notions, exposing prostate cancer cells alternately to very high and very low levels of testosterone may have clinical benefit and improve quality of life."
  January 2016 ,Medscape Medical News,Proton Pump Inhibitors May Increase Risk for Kidney Disease ,"Proton pump inhibitors such as omeprazole are linked to increased risks for chronic kidney disease and for acute kidney injury, according to two population-based analyses."
  January 2016 ,Medscape Medical News,Scrambler Therapy Benefit in Cancer-Related Neuropathic Pain,"Noninvasive scrambler therapy is emerging as a potential option for the treatment of cancer-related neuropathic pain, although uptake remains limited in the absence of major clinical trials."
  January 2016 ,Medscape Medical News,Quality of Life With Docetaxel and ADT in Prostate Cancer,"When docetaxel is added to androgen-deprivation therapy, patients with metastatic prostate cancer report no long-term effects on quality of life."
  January 2016 ,Reuters Health Information,Recro Pharma's Lead Painkiller Succeeds in Mid-Stage Trial,"Recro Pharma Inc said its lead painkiller reduced pain in post-operative orthopedic surgery patients and was safe and well tolerated, in a mid-stage trial."
  January 2016 ,Medscape Medical News,"After Great Pain, a Cold Cap for Chemo Hair Loss Came","Refrigeration expertise and anguish from the adverse effects of breast cancer chemotherapy came together in a British family, and gave rise to technologic innovation."
  January 2016 ,Medscape Medical News,High-Dose Vitamin D Shows Promising Effects in MS ,"Taking 10,400 IU cholecalciferol daily was associated with target serum levels of 25-hydroxyvitamin D and reductions in interleukin-17 T cells, which are believed to play a key role in MS, in a new study. "
  January 2016 ,Medscape Medical News,Molecular Signatures Explain Unique Responses to Vaccination ,Patients who describe influenza-like symptoms after vaccination have a distinct genetic signature compared with patients who do not have such a reaction. 
  January 2016 ,Medscape Medical News,"Intravaginal DHEA Eases Postmenopausal Vaginal Dryness, Pain ","Daily intravaginal DHEA suppositories give relief to postmenopausal women for whom sex is painful, but who cannot or do not want to use estrogen treatments."
  January 2016 ,Medscape Medical News,Which Kidney Cancer Drug on Progression? Surprising Answers,"Although cabozantinib has shown the best progression-free survival ever seen, nivolumab improves overall survival and has fewer adverse events."
  January 2016 ,Heartwire from Medscape,Filter Mask Might Lessen Diesel-Fume Cardiotoxicity in HF," ""This trial is the first to show that a filter can reduce both endothelial dysfunction and BNP increases in patients with heart failure during     diesel-exhaust exposure,"" according to researchers."
  December 2015 ,Reuters Health Information,Empirical Terbinafine for Nail Fungus Is Most Cost-effective,"Empirical treatment of onychomycosis with terbinafine is far more cost effective than confirmatory testing before treatment, according to new findings."
  December 2015 ,Heartwire from Medscape,'Triple Therapy' Raises Bleed Risk After PCI for MI: Study,"Regardless of P2Y12 receptor inhibitor used, the risk of bleeding complications went up by adding an oral anticoagulant to dual-antiplatelet     therapy—maybe more so with one particular antiplatelet."
  February 2016 ,Reuters Health Information,Levamisole-Adulterated Cocaine Linked to Pyoderma Gangrenosum,"Clinicians should be aware that levamisole-adulterated cocaine is a potential cause of pyoderma gangrenosum (PG), researchers warn."
  February 2016 ,Medscape Medical News,Flip Flop: ED Drugs Not Tied to Prostate Cancer Return,Erectile dysfunction (ED) is a common adverse effect of prostate cancer therapy. But is the use of these drugs tied to biochemical recurrence? New evidence counters an earlier study.
  February 2016 ,Medscape Medical News,First Chemo 'Antidote' Cuts Deaths From 5-FU Toxicity,The first and only approved antidote for severe toxicity related to a chemotherapy overdose dramatically reduces mortality.
  February 2016 ,Medscape Medical News,Activity With PD-1 Inhibitors in Upper GI Cancers,"Early-phase trials show encouraging antitumor activity for nivolumab and pembrolizumab in advanced gastric, esophagus, and gastroesophageal junction cancers."
  February 2016 ,Medscape Medical News,Cherry-Flavored e-Cigarettes Linked to Lung Irritant,"Flavored e-cigarettes, particularly cherry-flavored, expose users to benzaldehyde, a compound that can irritate the airways, at levels often greater than those seen with conventional cigarettes."
  February 2016 ,Medscape Medical News, Soy May Protect Against Fertility Harms of Endocrine Disruptors, A Harvard study is the first to find that women who eat soy and have been exposed to the endocrine disruptor BPA have higher chances of pregnancy success     and live birth after IVF.
  February 2016 ,Medscape Medical News,EU to Review Metformin Meds to Unify Renal Recommendations,"The European Medicines Agency is to review prescribing information with regard to the use of metformin in patients with renal impairment, with a view to     harmonizing advice on this issue across the EU."
  January 2016 ,Medscape Medical News,CHMP Recommends Coagadex for Factor X Deficiency,The medicine can be used as treatment for acute bleeding or as prophylaxis in patients with hereditary factor X deficiency. 
  January 2016 ,International Approvals,CHMP Backs Selexipag for Pulmonary Arterial Hypertension,Selective prostaglandin receptor agonist has mechanism distinct from prostacyclin and its analogs. 
  January 2016 ,News Alerts,"Eribulin Approved for Liposarcoma, Improves Survival","Already approved for use in breast cancer, eribulin is the first drug to show an improved overall survival in patients with liposarcoma."
  January 2016 ,Reuters Health Information,Smoking Cessation Pill vs Nicotine Patches or Lozenges,"Smoking cessation pills aren't any better than nicotine patches or lozenges at helping people successfully quit, a U.S. study suggests."
  January 2016 ,Medscape Medical News,Mixed Opioid Agent Adds to Growing List of Therapies for IBS-D,Studies suggest a new oral agent with mixed opioid effects may be a promising new option for irritable bowel syndrome with diarrhea; its approval adds to the growing list of options for the disorder.
  January 2016 ,Medscape Medical News,Topiramate for Substance Use: Upside/Downside,"Topiramate, which has shown promise as a treatment for substance use disorders, reduces the amount of cannabis users consume, but at the cost of increased adverse effects."
  January 2016 ,Medscape Medical News,Strenuous Physical Activity Linked to ALS in Older Women,"Genes and environment may interact with strenuous physical activity to increase risks, new data suggest."
  January 2016 ,Reuters Health Information,Refractive Outcomes Stable at Five Years After SMILE Procedure for Myopia,"Refractive outcomes remain stable at five years in the first eyes treated with small incision lenticule extraction (ReLEx SMILE, Zeiss) for myopia, report ophthalmologists from Germany."
  January 2016 ,Medscape Medical News,"After Dust Settles, Mixed Reaction to New US Dietary Guidelines"," Response to the new 2015-2020 Dietary Guidelines for Americans ranged from neutral to supportive to harsh critique; now that docs have had time to digest     the impact, Medscape gauged reactions."
  January 2016 ,Medscape Medical News,Oral Propranolol Best for Reducing Infantile Hemangioma,"Oral propranolol had a 95% clearance rate vs 43% for oral corticosteroids, according to a meta-analysis."
  January 2016 ,Medscape Medical News,FDA Panel Considers Allergen Immunotherapy Development,An FDA panel met to discuss issues around the clinical development of allergen immunotherapy products.
  January 2016 ,Medscape Medical News,Safe and Sound (So Far): A Radiopharmaceutical for GI Tumors,An investigative treatment for midgut neuroendocrine tumors demonstrated some unprecedented efficacy results in early analyses. Now the safety data are a bit more mature.
  January 2016 ,Medscape Medical News,Antipsychotics Boost Type 2 Diabetes Risk in Youth,"A new meta-analysis links second-generation antipsychotics with a significantly increased risk orf type 2 diabetes risk in youth, once again underscoring the serious metabolic risks of these agents."
  February 2016 ,Medscape Medical News,EHR Use Tied to Lower Adverse Event Rates ,"Hospitals that had fully electronic health records had lower rates of adverse drug events, hospital-acquired infections, and other adverse events among inpatients, researchers reported. "
  February 2016 ,Medscape Medical News,Higher-Dose SSRIs for Major Depression May Improve Response,Higher-dose SSRIs for major depression are associated with modest improvement and may be a viable way of boosting response in some patients.
  February 2016 ,Medscape Medical News,"IRIS: Diabetes Drug Reduces Recurrent Stroke, MI","A randomized trial shows that in patients with insulin resistance but no diabetes and a history of recent stroke or TIA, pioglitazone reduced recurrent stroke and myocardial infarction vs placebo. "
  February 2016 ,FDA Approvals,FDA Expands Use of Liver Drug to Subset of Patients,"The U.S. Food and Drug Administration has expanded the use of Gilead Sciences Inc's drug Harvoni (ledipasvir and sofosbuvir) to some hepatitis C patients in the advanced stage of cirrhosis, including those who have undergone liver transplant."
  February 2016 ,Medscape Medical News,"Cutting Cancer Drug Costs: No Pain, No Gain","Public policy changes could help control the escalating cost of cancer drugs, but not without making tradeoffs in the process, say some experts."
  February 2016 ,Medscape Medical News,New Consumer Advice on Prostate Cancer Includes 'Value',"New consumer advice guides include information on the 'relative value of treatments,' but the guide on prostate cancer has been met with criticism."
  February 2016 ,Medscape Medical News,Oral Opioids No Better Than NSAIDs for Knee OA Pain,A new systematic review has challenged the assumption that oral opioids provide stronger pain relief than NSAIDs in knee osteoarthritis. 
  February 2016 ,Medscape Medical News,"Therapy, Antidepressants Similarly Effective for Depression","A new ACP guideline recommended that physicians discuss the benefits, potential adverse effects, and costs of both treatments with patients. The guideline also addressed problems with St John's wort."
  February 2016 ,Medscape Medical News,Psychiatrists Urged to Support ECT Reclassification,The APA is encouraging its members to support the FDA's proposed reclassification of ECT devices from high- to low-risk.
  February 2016 ,Medscape Medical News,Antidiabetic Agent Helps Antipsychotic-Induced Dyslipidemia,"The antidiabetic agent metformin may offer an effective treatment for antipsychotic-induced dyslipidemia, new research suggests."
  February 2016 ,Medscape Medical News,New Diagnostic Test for Parkinson's?,"Biopsy of the submandibular gland may help identify Lewy-type synucleinopathy in patients with PD, a new study shows."
  February 2016 ,Medscape Medical News,Side Effects With Sorafenib More Pronounced in Thyroid Cancer,The incidence of side effects from the oral multikinase inhibitor sorafenib appears to be considerably higher among patients with differentiated thyroid cancer than those with renal cell or hepatocellular carcinoma.
  February 2016 ,Heartwire from Medscape,Amgen on GAUSS-3: Evolocumab Meets LDL-Based Primary End Points,"Teasing with top-line results, the company says the PCSK9 inhibitor dropped LDL-C vs ezetimibe at 24 weeks in patients intolerant of statins, similar to     what was shown in the 12-week GAUSS-2 trial."
  February 2016 ,Medscape Medical News,Does Pharma 'Highjack' FDA Public Comment on Cancer Drugs?,Meetings of the US Food and Drug Administration (FDA) Oncologic Drugs Advisory Committee include public comment. But who are the people commenting?
  February 2016 ,Medscape Medical News,Parental Depression: Long-term Impact on Children,"Children of depressed parents show significant reductions in academic performance at age 16 years, new research indicates."
  February 2016 ,Medscape Medical News,Proton Beam in Medulloblastoma: 'New Benchmark',"In children with medulloblastoma, proton-beam therapy has survival rates similar to standard radiotherapy, but fewer systemic toxicities."
  February 2016 ,Medscape Medical News,Benefit of Steroids Extends to Late Preterm Period,"In late preterm infants, antenatal betamethasone reduces the need for respiratory support at 72 hours and lowers the risk for severe respiratory morbidity, new research suggests."
  February 2016 ,Medscape Medical News,Rivastigmine Prevents Falls in  Patients With PD," The results are 'very encouraging and exciting' but need to be reproduced in larger trials, lead researcher says."
  February 2016 ,Medscape Medical News,Nonadherence to ADHD Meds: Red Flag for Illicit Drug Use?,Urine samples from ADHD patients show higher rates of illicit drug use among those nonadherent to prescribed stimulant medications.
  February 2016 ,Medscape Medical News,New Guidance: Bisphosphonate Holidays for Low-Risk Patients,"High-risk osteoporosis patients, however, are advised to continue therapy; discussion of the risks/benefits is encouraged."
  February 2016 ,News Alerts,"EU Panel Likes Nivolumab for Kidney Cancer, Other Drugs",A European advisory committee has recommended extending the indication for immunotherapy to include the treatment of advanced renal cell carcinoma.
  February 2016 ,International Approvals,CHMP Backs Ixekizumab (Taltz) for Plaque Psoriasis,"The monoclonal antibody targets interleukin 17A, a key driver of inflammation in psoriasis. "
  February 2016 ,Medscape Medical News,Telephone Triage Deflects ED Visits to Oncologists' Offices,"A novel telephone triage system helped deflect a significant number of ED visits by oncology patients into physicians' offices instead, saving the healthcare system considerable amounts of money."
  February 2016 ,Medscape Medical News,New APS Guideline on Postoperative Pain  ,"In a new American Pain Society guideline on postoperative pain management in children and adults, an expert panel recommends a multimodal approach."
  February 2016 ,Medscape Medical News,Question Over Role of RAS Blockers for Hypertension in Diabetes," A new meta-analysis suggests that in diabetes patients without kidney disease, any blood-pressure-lowering agent will do."
  February 2016 ,Medscape Medical News,New Evidence Backs Levetiracetam for Prolonged Seizure,"Levetiracetam is as good as phenytoin for the treatment of status epilepticus, new data suggest, and might even be cheaper."
  February 2016 ,Medscape Medical News,Ultra-Low-Dose Opioid May Quash Severe Suicidal Ideation,"Short-term use of ultra-low-dose buprenorphine may reduce suicidal ideation in severely depressed patients, new research shows."
  February 2016 ,Medscape Medical News,Opioids for Depression: Novel Treatment Tested,The combination of buprenorphine and samidorphan shows some efficacy as an adjunctive therapy for treatment-resistant major depression.
  February 2016 ,Medscape Medical News,Ganglion Block Beats Blood Patch for Dural Puncture Headache,"This approach should be the first-line therapy for obstetric patients experiencing postdural puncture headache, researchers say."
  February 2016 ,Medscape Medical News,Meditation Provides Short-Term Relief of Back Pain in Seniors,"A new study has found that although short-term improvements may be noted among older adults using meditation to help manage lower back pain, the effects are not long-lasting. "
  February 2016 ,Medscape Medical News,"Oral Steroids, NSAIDs Equally Safe, Effective for Acute Gout","A large, multicenter randomized trial found that oral prednisolone and oral indomethacin were equally effective at reducing acute gout pain in patients presenting to emergency departments. "
  February 2016 ,Medscape Medical News,"Marijuana Use Tied to Drug, Alcohol Abuse, Nicotine Dependence",A new study sounds a note of caution about underappreciated risks linking marijuana use to subsequent development of alcohol and drug abuse and nicotine dependence.
  February 2016 ,Medscape Medical News,Depression Symptoms Ongoing Even With Optimal Treatment,"Many patients with major depressive disorder continue to experience symptoms despite optimal treatment, a US poll shows."
  February 2016 ,Medscape Medical News,ASCO on Ovarian Suppression in Young Breast Cancer Patients,"The latest results on ovarian suppression in premenopausal women with breast cancer,  hailed as practice changing, have now been incorporated into clinical guidelines."
  February 2016 ,Medscape Medical News,Disease Suppression Persists With Ozanimod at 72 Weeks in MS,"The 48-week extension of the RADIANCE trial showed persistent benefit for ozanimod, reduced gadolinium-enhancing lesions, and a low relapse rate. "
  February 2016 ,Medscape Medical News,Adding an Antipsychotic Helps Treat Pain,A literature review finds that the atypical antipsychotic olanzapine has the most evidence supporting its use in various pain syndromes.
  February 2016 ,Medscape Medical News,Disability Accumulation Varies in Moderately Advanced MS ,"Disability accumulation may be independent of prior disease progression, but its trajectory is highly variable, suggesting that patients with higher EDSS scores may still benefit from stronger therapies."
  February 2016 ,Medscape Medical News,Organ Complications Can Hit Early in Systemic Sclerosis,"For most people with systemic sclerosis, pulmonary, heart, and other complications start early and ramp up quickly, according to an analysis of nearly 10,000 EUSTAR patients."
  February 2016 ,FDA Approvals,FDA Clears Brivaracetam (Briviact) for Partial-Onset Seizures,The levetiracetam analogue is approved for adjunctive therapy for treatment of partial-onset seizures in patients age 16 and older with epilepsy.
  February 2016 ,Medscape Medical News,Stroke Prevalence Linked to Poor Air Quality,"Higher stroke rates correspond to areas of the US and China with the most air pollution, a new study shows."
  March 2016 ,Medscape Medical News,Investigational Cream Promising for Epidermolysis Bullosa,"The concentrated form of an old ingredient -- allantoin, a diureide of glyoxylic acid -- has shown benefit in people with the rare condition of epidermolysis bullosa in a phase 2b study."
  March 2016 ,Medscape Medical News,Long-term Aspirin Tied to Small Drop in Overall Cancer Risk,"Long-term low-dose aspirin could decrease the risk for cancer, especially colorectal cancer; aspirin may also benefit patients who receive CRC screening and have even greater impact on those who don't."
  March 2016 ,Medscape Medical News,Cannabis in First-Episode Psychosis Linked to Poor Outcomes,"Cannabis use in early psychosis is linked to higher hospital admission risk, prolonged stays, and antipsychotic drug failure."
  March 2016 ,Reuters Health Information,Many Lens Implant Patients May Develop Cataracts Within 10 Years,"Many patients who get lens implant surgery to correct vision problems may develop cataracts or elevated pressure around the eyes within 10 years after the procedures, a Swiss study suggests."
  March 2016 ,Medscape Medical News,FDA Clears New Contact Lens That Senses Eye Pressure Changes,"The Triggerfish contact lens provides 24-hour continuous monitoring of changes in intraocular pressure patterns that otherwise could not be obtained, the FDA said. "
  March 2016 ,Reuters Health Information,Glaucoma Drops May Help in Refractory AMD,"When age-related macular degeneration (AMD) is refractory to intravitreous anti-vascular endothelial growth factor (anti-VEGF), adding dorzolamide-timolol eye drops may be helpful, according to a small pilot study."
  March 2016 ,Medscape Medical News,Immuno-oncology Driving More Precise Cancer Treatment,"A predicted shift in combination treatments, in which new immunotherapies treat the host, not the tumor cells, will mean that oncologists could become immunologists and virologists."
  March 2016 ,Medscape Medical News,Novel 'Gene Silencer' Shows Promise in Huntington's ,The first clinical trial of a second-generation antisense oligonucleotide that targets the cause of Huntington's disease is underway after promising results in animal testing.  
  March 2016 ,Heartwire from Medscape,Lower CAD Risk Hinted With Gene Variants Linked to Lower Triglycerides,"The question now is whether an antibody that achieves loss of function in ANGPTL4 ""can be safely given to achieve lower coronary disease,""     commented an expert observer."
  March 2016 ,Medscape Medical News,Can the Endobarrier Help Obese Diabetics Running out of Options? ,The first trial of a duodenal-jejunal bypass liner together with GLP-1 agonist therapy in morbidly obese diabetic patients who are failing therapy suggests     this combo may kick-start behavior changes.
  March 2016 ,Medscape Medical News,Peanut Trial LEAPS Back Into Limelight at Allergy Meeting,"The much-anticipated update from the LEAP study on the protective effects of early peanut exposure in infants will be presented, as will data on the safety of asthma medications."
  March 2016 ,Medscape Medical News,Unilateral ECT Equal to Bilateral Approach for Major Depression,"Twice-weekly high-dose unilateral ECT for severe depression is as effective as bilateral ECT, with fewer cognitive side effects, new research shows."
  March 2016 ,Medscape Medical News,Have Difficult-to-Treat Pain Patients? Try Genetic Testing,"Genetic testing might help sort out which medications to prescribe to pain patients, new research suggests."
  February 2016 ,Reuters Health Information,Infliximab May Top Cyclosporine for Steroid-Refractory Ulcerative Colitis,"Infliximab may be slightly better than cyclosporine for treating patients with steroid-refractory ulcerative colitis (UC), according to results from a systematic review and meta-analysis."
  February 2016 ,International Approvals,CHMP Backs Two Hemophilia B Drugs (Idelvion and Alprolix),Both blood coagulation factor IX products are indicated for treatment and prophylaxis of bleeding in patients of all ages with hemophilia B.
  February 2016 ,Medscape Medical News,Patients Rate Physicians' Responses to DTC Genomic Testing,"Patients using direct-to-consumer genomic tests had unrealistic expectations of the utility of testing and of the ability of healthcare providers to interpret and explain results, a new study showed."
  February 2016 ,Medscape Medical News,"Flibanserin Approval Not Supported by Data, Review Suggests",The female libido drug showed a significant adverse event rate and only marginal efficacy in a new meta-analysis; experts questioned US Food and Drug Administration approval.
  February 2016 ,Medscape Medical News,Multimodal Care Reduces All-Cause Mortality in Opioid Users,"Those patients who received mental health, addiction, or rehabilitative treatment were 40% less likely to die within 6 months of starting on opioids than those who did not."
  February 2016 ,Medscape Medical News,Another Option for Opioid-Induced Constipation?,A new drug in development is superior to placebo in treating opioid-induced constipation and doesn't interfere with analgesic effect.
  February 2016 ,International Approvals,CHMP Backs Emtricitabine/Tenofovir Alafenamide for HIV,"The combo, called Descovy, is an alternative treatment option to Gilead's tenofovir disoproxil fumarate (Viread) and is expected to have similar efficacy, the committee said. "
  March 2016 ,Kaiser Health News,California to Kick Out Poorly Performing Hospitals? ,Providers and insurers are balking at a Covered California proposal to eject hospitals with inordinately high costs and low quality from its networks.
  March 2016 ,Medscape Medical News,EMA Launches Investigation Into Gadolinium Deposits in Brain,Concern over gadolinium deposits in patients undergoing multiple MRIs has led the European Medicines Agency to launch a review of the potential risks. The FDA launched a similar investigation last summer. 
  March 2016 ,Medscape Medical News,Risky Drug Prescriptions Cut by Multipronged Intervention,"Primary care prescribing of NSAIDs and antiplatelet agents for high-risk patients dropped with education, informatics, and financial incentives."
  March 2016 ,Medscape Medical News,"For Arthritis Pain: Diclofenac Best, Acetaminophen Worst",Diclofenac was most effective and acetaminophen least effective for relieving pain in knee or hip osteoarthritis.  
  March 2016 ,Medscape Medical News,"Marijuana for Cancer: No Benefit, but Don't Tell Patients","As more states approve medical marijuana, oncologists should be prepared to field questions from patients, but the available scientific data are limited."
  March 2016 ,Medscape Medical News,Legalized Cannabis and the Brain: NIDA Sounds the Alarm,NIDA researchers sound the alarm over a possible increase in unknown harms brought on by the wave of cannabis legalization now sweeping the US.
  March 2016 ,Medscape Medical News,'Difficult' Patients More Likely to Be Medically Misdiagnosed,"Patients who engage in disruptive behaviors may distract physicians, at the expense of important clinical details, new research shows."
  March 2016 ,WebMD Health News,A 'Remarkable' New Treatment for Cataracts,Scientists have described a cure for cataracts that involves regrowing the lens in the eye using stem cells.
  March 2016 ,Medscape Medical News,Methadone in Palliative Care? This Guidance Will Aid Use,"To minimize overdose risks, panel recommends adherence to multispecialty guidelines and careful use of methadone in palliative care."
  March 2016 ,Medscape Medical News,Reslizumab Effective in Chronic Sinusitis With Nasal Polyps,"For a subgroup of patients, an anti-interleukin-5 antibody improved asthma exacerbation rates, lung function, and quality of life, according to a subanalysis of data from two pivotal phase 3 trials."
  March 2016 ,Medscape Medical News,Low-Dose Steroids Generally Safe in Rheumatic Diseases ,A EULAR task force has concluded that long-term use of glucocorticoid doses of 5 mg/day or less is generally safe in treating rheumatic diseases. 
  March 2016 ,Medscape Medical News,'Legal LSD': Dangerous Party Drug Sold Online,"A 'legal high' that has potentially serious adverse effects is being sold online to partygoers as LSD, say Spanish researchers, who warn of the rising tide of novel psychoactive substances."
  March 2016 ,Medscape Medical News,Dose-Dense Chemo Boosts Survival in Premenopausal Breast Cancer,Adjuvant chemotherapy given every 2 weeks improved overall survival by almost a third compared with the standard 3-week interval.
  March 2016 ,FDA Approvals,FDA OKs Crizotinib (Xalkori) for ROS-1-Mutated Lung Cancer,The FDA has approved crizotinib for the treatment for patients with ROS-1-positive non-small cell lung cancer. 
  March 2016 ,Medscape Medical News,Cord-Cutting Technique Smooths Cellulite for 3 Years,"A one-time subcision treatment, in which fibrous septae underlying the characteristic cellulite dimples are cut, is effective and safe, 3-year data show."
  March 2016 ,Reuters Health Information,Adverse Childhood Experiences Tied to Less Well-Being in Adults,"Adverse childhood experiences (ACE) such as the death of a close friend or relative, prolonged absence of a parent or witnessing a shooting or stabbing are associated with less well-being in young adults, according to University of Minnesota researchers."
  March 2016 ,Medscape Medical News,Safety Data Accumulating for Combination Asthma Drugs,"The first of a series of safety studies mandated by the FDA suggests that the black-box warning on inhalers might not be warranted; however, patients with the most severe disease were excluded."
  March 2016 ,Medscape Medical News,"Early-Term Elective Delivery May Be OK, Study Suggests",Infants born electively at 37 to 38 weeks' gestation did not have an increased risk for neonatal morbidity or infant mortality compared with those who were expectantly managed and born at full term.
  March 2016 ,Medscape Medical News,Topical Anticholinergic Reduces Underarm Hyperhidrosis,"An investigational anticholinergic gel noninvasively reduces excess sweating with minimal adverse effects, a phase 2b study suggests."
  March 2016 ,Medscape Medical News,New Concussion Score for Children Flags Higher-Risk Cases  ,Use of a simple 12-point score successfully identified children with concussion who were at higher risk for prolonged symptoms. 
  April 2016 ,Medscape Medical News,HPV Vaccine Side-Effects Class-Action Suit Planned in Japan ,Lawyers representing girls with adverse effects after HPV vaccination are preparing a lawsuit against the government and the manufacturers.
  April 2016 ,Medscape Medical News,Prolonged Nightly Fasting Cuts Risk for Breast Cancer Return,Nighttime fasting of 13 hours or longer was associated with a significantly lower risk for recurrence in women with early-stage breast cancer.
  March 2016 ,Medscape Medical News,Baricitinib Offers Promise of Remission in Refractory RA ,The oral Janus kinase 1 and 2 inhibitor baricitinib significantly increased ACR20 response rates and improved physical function in patients with rheumatoid arthritis for whom other therapies had failed. 
  March 2016 ,Reuters Health Information,Keryx Says Anemia Drug Succeeds in Study of Kidney Patients,"Keryx Biopharmaceuticals Inc on Tuesday said its drug to treat iron deficiency anemia in chronic kidney disease patients not yet requiring dialysis met the goals of a late stage clinical trial, potentially paving the way for an expanded approval of the treatment."
  March 2016 ,FDA Approvals,Defibrotide Approved for Serious Disorder After HSCT,This is the first treatment approved for a rare but often fatal complication that can occur in cancer patients who receive hematopoietic stem cell transplants.
  March 2016 ,Medscape Medical News,Antipsychotics Linked to Mortality in Parkinson's,"Comorbidities should be checked, PD drugs adjusted, and perhaps behavioral approaches tried before an antipsychotic is introduced, researchers say."
  March 2016 ,Reuters Health Information,Acupuncture May Ease Hot Flashes in Women With Breast Cancer,"Acupuncture may help ease hot flashes in women with breast cancer who often can't take traditional hormone treatments, according to a new study from Italy."
  March 2016 ,Reuters Health Information,Diclofenac Best Treatment in ED for Renal Colic: Study,"The most effective sustained emergency department (ED) analgesia for renal colic is intramuscular (IM) diclofenac, not intravenous (IV) morphine, according to results from a randomized controlled trial."
  March 2016 ,Medscape Medical News,Possible Drug Risks Buried in Delayed FDA 'Watch Lists',"The agency has finally posted quarterly reports for 2015 that list drugs with potential signals of serious risk, such as stroke for SGLT-2 inhibitors. FDA critics say its early warning system needs fixing."
  March 2016 ,Medscape Medical News,Obesity Survey Uncovers Striking Clinician 'Knowledge Gap'," ""The most striking observation...is that it demonstrates a considerable knowledge gap in the indications, efficacy, and safety of currently FDA-approved     drugs for obesity,"" says one expert."
  March 2016 ,Heartwire from Medscape,PPIs May Lower GI Events After DAPT With Low-Dose Aspirin ," Based on new analysis from COGENT, ""one could make an argument to consider routine PPIs"" in these CAD patients, said the senior author. ""But that does go     beyond current guidelines."""
  March 2016 ,Medscape Medical News,Study Suggests Bringing Back Whole-Cell Pertussis Vaccine,Using a mixed vaccine series with whole-cell and Tdap could reduce pertussis incidence dramatically. But would parents accept the old vaccine with its associated adverse effects?
  March 2016 ,Medscape Medical News,Ketamine Linked to Bladder Toxicity,"Recreational use of ketamine has been linked to bladder toxicity, raising concerns that this may affect its clinical potential as a rapid-acting treatment for depression and other disorders."
  March 2016 ,Medscape Medical News,Tocilizumab Ups Giant Cell Arteritis Remissions in Early Trial,Patients with giant cell arteritis treated with tocilizumab were more likely to reach and maintain complete remission and were able to taper off steroids more quickly in a randomized trial. 
  March 2016 ,Medscape Medical News,Dual-Drug Strategy Reduces Carpet of Polyps in FAP Patients,Colon carpeted with polyps in FAP patients can be favorably affected with a novel dual-drug strategy that offers the first really tenable treatment for this condition.
  March 2016 ,Medscape Medical News,Botox Alleviates Neuropathic Pain,"A series of two doses of botulinum toxin A relieved neuropathic pain better than did placebo, new randomized findings show."
  March 2016 ,Medscape Medical News,ENDO 2016: Centennial Celebration Will Mix Old With New , The program of the Endocrine Society's meeting will feature odes to past endocrine achievements and the many advances for which they paved the way.
  March 2016 ,FDA Approvals,Ixekizumab (Taltz) for Plaque Psoriasis Clears FDA,"The monoclonal antibody targets interleukin 17A, which drives inflammation in psoriasis, and is intended for patients who are candidates for systemic therapy. "
  March 2016 ,Medscape Medical News,Diabetes Drugs Have Positive Effect in MS,"Metformin and pioglitazone help regulate immune and inflammatory responses in obese patients with multiple sclerosis who also have metabolic syndrome, a new study suggests."
  March 2016 ,Medscape Medical News,Number of Elderly at Risk for Major Drug-Drug Event Doubles,"Two-thirds of elderly are taking five or more prescription/nonprescription medications, a new study showed. Experts calls for better monitoring systems, more patient input in drug lists."
  April 2016 ,Medscape Medical News,Investigational Long-Acting Growth Hormone Shows Promise,A twice-monthly recombinant human growth hormone demonstrates efficacy and safety and may improve compliance over daily formulations.
  April 2016 ,Medscape Medical News,ASCO Urges Aggressive Efforts to Increase HPV Vaccination  ,"Despite many American medical professional bodies strongly recommending HPV vaccination, uptake remains low. Now oncologists are being told to get involved.   "
  April 2016 ,FDA Approvals,Venetoclax Approved in US for Certain CLL Patients,"The new drug has been approved for patients with chronic lymphocytic leukemia (CLL) who harbor the 17p deletion, which has a poor prognosis."
  April 2016 ,Medscape Medical News,e-Cigs Cut Tobacco Use in Patients With Serious Mental Illness,"Individuals with serious mental illnesses may be able to reduce their tobacco consumption with the use of electronic cigarettes, without exacerbating psychopathologic symptoms, say UK scientists."
  April 2016 ,Reuters Health Information,Exercise May Aid Sleep for Overweight Men With Insomnia,"Overweight men with chronic insomnia fall asleep more easily and quickly after a six-month aerobic exercise program, according to a new study in Finland."
  April 2016 ,Medscape Medical News,FDA: Metformin Safe for Some Patients With Renal Problems,"UPDATED // Changing its course in response to mounting evidence, the agency said the diabetes drug can be used safely in patients with mild and, in some cases, moderate kidney impairment. "
  April 2016 ,Medscape Medical News,NCCN Scrutinizes Sexual Dysfunction in Cancer Survivors,The National Comprehensive Cancer Network (NCCN) Guidelines for Survivorship focus this year on issues of sexual health for both men and women.
  April 2016 ,Medscape Medical News,Parkinson's Drug Highly Effective for Resistant Depression,Enhancement of the dopaminergic system with the Parkinson's drug pramipexole can be extremely effective in alleviating symptoms of treatment-resistant unipolar and bipolar depression.
  April 2016 ,Medscape Medical News,NCCN: Shorter RT Course 'Preferred' for Breast Conservation,"The latest NCCN guidelines for breast cancer urge the use of hypofractionation, in which radiation is delivered for 3 rather than 5 weeks."
  April 2016 ,WebMD Health News,Specialists Say Childhood Asthma Is Overdiagnosed,"In an article published in the journal Archives of Disease in Childhood, two respiratory specialists claim that doctors are overdiagnosing asthma in children, with inhalers being prescribed needlessly."
  April 2016 ,Medscape Medical News,Gut Microbiota Altered in First-Episode Schizophrenia,"Individuals with first-episode schizophrenia have alterations in gut microbiota that appear to be driven by early antipsychotic therapy and are linked to inflammation, Finnish data indicate."
  April 2016 ,Medscape Medical News,"Novel Drug May Offer Hope in Prader-Willi Syndrome, Obesity","Beloranib reduces weight and hyperphagia in Prader-Willi syndrome and may also hold promise for other severe obesity conditions, but first the company must     prove that it doesn't raise thrombotic risk."
  April 2016 ,International Approvals,EMA Committee Backs First Oral Drug for Fabry Disease ,Migalastat (Galafold) may provide a more convenient treatment option for patients with this rare genetic disease. 
  April 2016 ,Reuters Health Information,"Regeneron, Sanofi Eczema Drug Clears Hurdles in Big Trials","Regeneron Pharmaceuticals Inc and Sanofi said on Friday their experimental treatment for eczema proved highly effective in two large studies, without serious side effects often seen with standard treatments for the chronic inflammatory skin disease."
  April 2016 ,Medscape Medical News,Oral GLP-1 Agonist Promising in Phase 2 in Type 2 Diabetes," A novel oral formulation of a long-acting GLP-1 agonist could provide HbA1c and weight-loss benefits similar to the injectables in type 2 diabetes, but in     a daily pill instead."
  April 2016 ,Heartwire from Medscape,HOPE-3: Statins Lower CV Events in Intermediate-CHD-Risk Patients,"UPDATED // Alone or with blood-pressure-lowering therapy, at least in those with elevated baseline BP, rosuvastatin lowered composite end points by 24% to 29% vs     placebo."
  April 2016 ,News Alerts,FDA Investigates Counterfeit Materials in Surgical Mesh,The FDA is investigating allegations that Boston Scientific used counterfeit raw material in the manufacturing of urogynecologic surgical mesh.
  April 2016 ,International Approvals,EMA Panel Backs Pandemic Avian Influenza Vaccine,The European Medicines Agency's Committee for Medicinal Products for Human Use has recommended granting marketing authorization for the Pandemic Live Attenuated Influenza Vaccine.
  April 2016 ,Medscape Medical News,Endocrine Society Advises Against Compounded Hormone Use,"A new scientific statement details the science of hormonal compounds for treating menopausal symptoms, sexual dysfunction, and thyroid conditions,     emphasizing the superiority of FDA-approved products."
  April 2016 ,Medscape Medical News,Pricey PCSK9 Inhibitors Require Careful Patient Selection,"The drugs, for familial hypercholesterolemia and atherosclerotic cardiovascular disease, cost about $14,000/year in the US, even though the effect on morbidity and mortality has yet to be determined."
  April 2016 ,Medscape Medical News,Peginterferon Beta-1a Efficacy in MS Sustained Long-term,An extension study of the pivotal ADVANCE trial demonstrates sustained efficacy of peginterferon beta-1a with long-term treatment in relapsing MS. 
  April 2016 ,Medscape Medical News,Everolimus Data for Seizures in Tuberous Sclerosis 'Exciting',"The new results may open the door to eventually being able to treat epilepsy, not just seizures, researchers say."
  April 2016 ,Medscape Medical News,Repeated Ketamine May Sustain Antidepressant Effect,Repeated administration of ketamine may help prolong the antidepressant effect in patients with treatment-resistant depression.
  April 2016 ,Medscape Medical News,First Osteoporotic Break Increases Subsequent Fracture Risk,"The risk of a second osteoporotic fracture is greatest in the year following a first break, and patients should be treated immediately to prevent future     fractures. Risk remains high for 10 years."
  April 2016 ,Medscape Medical News,Once-Daily Epilepsy Drug Equivalent to Twice-Daily Drug,A new study shows eslicarbazepine acetate is equivalent in efficacy to twice-daily carbamazepine monotherapy.
  April 2016 ,Medscape Medical News,Fingolimod Easier to Swallow Than Dimethyl Fumarate?," Patients with multiple sclerosis are more likely to discontinue dimethyl fumarate than fingolimod after 2 years or less, largely because of tolerability issues, a real-world study has found. "
  April 2016 ,Medscape Medical News,Hope for Advanced HNSCC at Last From Immunotherapy,Nivolumab significantly improved survival for patients with advanced refractory head and neck cancer.
  April 2016 ,Medscape Medical News,Sleep Problems Linked to Reduced Brain Volume ,"Sleep problems in older adults have been link to reduced brain volume, new research shows."
  April 2016 ,Medscape Medical News,MammaPrint Shows Which Breast Cancer Patients Can Skip Chemo,The first outcome data from a huge European trial show that the 70-gene assay can identify patients who can safety skip chemotherapy.
  April 2016 ,Medscape Medical News,Sorafenib a Possible Option for Medullary Thyroid Carcinoma?," Sorafenib might be a suitable option for treating advanced MTC, when the standard drugs are not available."
  April 2016 ,Medscape Medical News,Metformin Remains Best First-line Therapy for Type 2 Diabetes ,"Despite the introduction of many new drug classes to treat type 2 diabetes, a contemporary systematic review concludes that metformin should remain as     first choice for first-line therapy."
  April 2016 ,Medscape Medical News,Uneven Use of Antibiotic Prophylaxis in Pediatric Surgery ,Antibiotic prophylaxis rates varied greatly among pediatric hospitals; it was both over- and underused.
  April 2016 ,Medscape Medical News,New AAN Guideline on Use of Botulinum Neurotoxins," The American Academy of Neurology has released new recommendations on the use of botulinum neurotoxin products in the treatment of blepharospasm, cervical dystonia, adult spasticity, and headache."
  April 2016 ,Medscape Medical News,Depression Yet Another Side Effect of ADT?,Older men (age 65 and older) with localized prostate cancer may be at increased risk of developing depression.
  April 2016 ,Medscape Medical News,Slashing the Cost of Cure: Hep C Generics' First Data Shine,"Generic medications for hepatitis C, which are about 1% of the cost of brand-name drugs, pay back big, according to preliminary results from the REDEMPTION-1 trial."
  April 2016 ,Medscape Medical News,More Patients Living Longer: Latest Immunotherapy Data,"The latest data for survival on nivolumab are better than those previously seen with ipilimumab, and both show that some patients live for years."
  April 2016 ,Medscape Reader Polls,Reader Poll: What's Your Opinion of FDA Watch Lists?,The FDA has fallen behind on reporting serious adverse effects with drugs.
  April 2016 ,Medscape Medical News,OTC Antihistamine Promotes Remyelination in MS  ,The first randomized trial showing efficacy for a remyelinating agent in MS suggests it is possible to repair injury to nerve cells.  
  April 2016 ,Heartwire from Medscape,"Vitamin D Boosts LVEF, Not Walk Distance, in HF Study","Although vitamin D treatment is safe and may improve ventricular remodeling, and by extension, outcomes, in patients with heart failure, say investigators, observers are skeptical."
  April 2016 ,Medscape Medical News,"SSRI May Help Alzheimer's Agitation, but Caveats Abound","The selective serotonin reuptake inhibitor citalopram may reduce agitation in patients with Alzheimer's disease, but only at high doses, which are not recommended by the FDA."
  May 2016 ,Medscape Medical News,New Practice Guidelines on Antipsychotic Use in Dementia,Judicious use of antipsychotics to treat agitation or psychosis in patients with dementia is the focus of new practice guidelines from the American Psychiatric Association.
  May 2016 ,Medscape Medical News,Adjuvant Whole-Brain Radiotherapy: End of an Era?,Updated data from the N0574 study confirm no improvement in overall survival but greater cognitive deterioration with adjunct whole-brain radiotherapy in patients with one to three brain metastases.
  May 2016 ,Medscape Medical News,"Scalp Cooling Safe, Long-term European Data Show","Scalp cooling, which reduces hair loss during chemotherapy, has not been embraced in the United States, although 40 years of European data show that it is safe."
  May 2016 ,Medscape Medical News,From Brintellix to Trintellix: Drug's Name Changes for Safety ,The FDA has approved a brand name change for the antidepressant Brintellix to decrease the risk of prescribing and dispensing errors due to name confusion with an antiplatelet agent.
  May 2016 ,Medscape Medical News,Ixazomib in First All-Oral Triplet for Multiple Myeloma,"The trial showing efficacy for ixazomib in the first oral triplet regimen for the treatment of relapsed, refractory multiple myeloma has now published."
  May 2016 ,FDA Approvals,FDA Okays Oral Formulation of Perampanel (Fycompa),"Perampanel (Fycompa) will now be available in oral suspension formulation for partial-onset seizures with or without secondary generalized seizures, as well as primary generalized tonic-clonic seizures for patients aged 12 years and older."
  May 2016 ,Kaiser Health News,Hospital Discharge: One of the Most Dangerous Times for Patients,"Within two weeks of Joyce Oyler's discharge from the hospital, sores developed in her mouth and throat, and blood began seeping from her nose and bowels."
  April 2016 ,FDA Approvals,"FDA Okays Pimavanserin for Hallucinations, Delusions in PD",The drug is the first one approved to treat hallucinations and delusions associated with psychosis in Parkinson's disease.
  April 2016 ,FDA Approvals,FDA Expands Breath-Actuated Inhaler Use to Kids as Young as 4,The rescue inhaler ProAir RespiClick offers a new option for younger patients that eliminates the need for hand-breath coordination during inhalation.
  April 2016 ,International Approvals,CHMP Likes Gilead's TAF-Based HIV Regimen Odefsey,"Odefsey is a fixed-dose combination pill containing emtricitabine, rilpivirine, and tenofovir alafenamide that recently cleared the US Food and Drug Administration."
  April 2016 ,International Approvals,European Panel Endorses Three Cancer Drugs,The European regulators were busy this week with announcements about two drugs for hematologic cancers and one for neuroendocrine tumors.
  April 2016 ,International Approvals,EMA Panel Backs Daclizumab (Zinbryta) for Multiple Sclerosis,"Daclizumab, a once-monthly injection, offers a targeted mechanism of action that is not expected to cause broad and prolonged immune cell depletion."
  April 2016 ,Medscape Medical News,Yoga Improves Quality of Life in Pulmonary Hypertension,"Adults with pulmonary arterial hypertension could derive some relief from yoga, results from a preliminary study suggest. The 12-week program eased anxiety and depression, among other measures."
  April 2016 ,Medscape Medical News,No Link Between Smoking Cessation Meds and Serious Side Effects,A large study of psychiatric and nonpsychiatric patients showed no increased risk for previously suggested neuropsychiatric side effects that prompted an FDA box warning.
  April 2016 ,Medscape Medical News,Natalizumab Misses Endpoint in Secondary Progressive MS,"In the ASCEND trial, treatment did not delay disease progression, the primary endpoint, although there was a benefit on upper-extremity function. "
  April 2016 ,Medscape Medical News,Off-Label Ketamine Prescribing: US Psychiatrists Troubled,"With limited evidence ketamine is effective for the short-term treatment of depression and almost no long-term safety and efficacy data, US psychiatrists are troubled by off-label prescribing."
  April 2016 ,Medscape Medical News,Adverse Reactions to Antihistamines More Common Than Thought,"Headaches, sleepiness, rashes, behavioral changes, and convulsions were among the adverse events linked to antihistamine use in children in a population-based study."
  April 2016 ,Medscape Medical News,Release Raises False Alarm Over Hep B Meds and Cancer Risk,"A news release issued at the International Liver Congress warned that long-term treatment of hepatitis B is linked to colorectal and cervical cancer, but the study came to the opposite conclusion."
  April 2016 ,Medscape Medical News,Dichlorphenamide Shows Clear Benefit in Periodic Paralysis,Dichlorphenamide reduces the rate and severity of muscle weakness attacks and improves quality of life in patients with hypokalemic and hyperkalemic periodic paralysis.
  April 2016 ,Medscape Medical News,Latest Data: Calcium Supplements Not Associated With CVD,"New analysis shows calcium supplements and/or vitamin D do not adversely affect CVD outcomes in middle-aged or older men and women -- an important finding, given their role in osteoporosis prevention."
  May 2016 ,Medscape Medical News,CKD Tied to Increased Risk for Hospital-Acquired Complications,Hospitalized patients with chronic kidney disease were 19% more likely than those with normal kidney function to experience complications in a review of outcomes from a population-based cohort.
  May 2016 ,Medscape Medical News,MS Drug Linked to Colorectal Cancer Risk,"Despite its cardiotoxicity -- and now possibly colorectal cancer risk -- mitoxantrone might still be an appropriate therapy in carefully selected patients, researchers say."
  May 2016 ,Medscape Medical News,Immediate ADT Improves Survival in Relapsed Prostate Cancer,"Delayed ADT was associated with worse overall survival in men with PSA relapsed or noncurable prostate cancer, but there are caveats."
  May 2016 ,Medscape Medical News,DBS Cuts Depression in Treatment-Resistant Patients,A new study shows that stimulation of the ventral anterior limb of the internal capsule significantly reduces depressive symptoms in patients with treatment-resistant depression.
  May 2016 ,Medscape Medical News,Botulinum Toxin Beats Neuromodulation for Overactive Bladder,"Onabotulinum toxin A injection appears to be more effective than sacral neuromodulation for urinary incontinence, but comes with more adverse effects, including urinary tract infection."
  May 2016 ,Medscape Medical News,Prostate Cancer: French HIFU Study Adds to Debate,"A French study used HIFU to perform hemiablation of the prostate in men with low- and intermediate-risk cancer, adding to the debate on how and when the approach should be used."
  May 2016 ,News Alerts,"Olanzapine Linked to Rare but Serious Skin Reaction, FDA Warns",The US Food and Drug Administration is warning that the antipsychotic olanzapine has been linked to a rare but potentially life-threatening skin condition.
  May 2016 ,Medscape Medical News,'Major' Ketamine Discovery May Lead to New Antidepressants,A 'major' discovery that explains how ketamine produces its swift antidepressant effect may lead to the development of rapid-onset agents that have none of the harms typically linked to the drug.
  May 2016 ,Medscape Medical News,FDA Panel Votes for IR Opioid but Without Abuse Labeling,"Despite the drug company's presentations, FDA advisory committee members didn't find enough evidence to recommend abuse-deterrent labeling for the new immediate-release product. "
  May 2016 ,Medscape Medical News,"Testosterone Pill Is Safe, Has 'Very Good Science'","A new oral testosterone formulation for hypogonadism has no liver toxicity, which has been a problem with other testosterone pills."
  May 2016 ,Medscape Medical News,New FDA-Approved Prostate 'Tool': Will You HIFU?,High-intensity focused ultrasound (HIFU) is approved for prostate ablation but not for the treatment of prostate cancer. Why? What now?
  May 2016 ,Heartwire from Medscape,"Warfarin, AF May Each Contribute to Dementia Risk in AF","Anticoagulation clearly plays a role in long-term brain health, a researcher notes, but ""we learned as well that atrial fibrillation is an additive disease state, in that it increases risk beyond anticoagulation."""
  May 2016 ,Heartwire from Medscape,VANISH: Ablation for Recurrent VT Bests Intensified Amiodarone,"UPDATED // Catheter ablation reduced the primary outcome compared with aggressive drug therapy and should be the preferred treatment in this population, the authors     said."
  May 2016 ,Medscape Medical News,ToxT Adds Time Dimension to Assess AEs of Cancer Treatment,"A new analytic approach, known as Toxicity over Time (ToxT), incorporates the dimension of time into adverse event reporting in oncology clinical trials."
  May 2016 ,Medscape Medical News,Ultrasound Thalamotomy Benefits Essential Tremor ,"The investigational treatment of focused ultrasound shows significant improvement over sham treatment at 3 months, with sustained improvement at 12 months."
  May 2016 ,Heartwire from Medscape,Perioperative Rosuvastatin Fails to Curb Cardiac Surgery Complications," Although the adverse effects on renal function may relate to patient ethnicity or rosuvastatin use, ""a class effect of statin therapy in patients     undergoing cardiac surgery cannot be ruled out,"" the authors said."
  May 2016 ,Medscape Medical News,AHA/ASA Issues First-Ever Stroke Rehabilitation Guidelines ,The new guidelines call for intensive multidisciplinary treatment of patients after a stroke and stress the importance of communication and coordination among those providing care. 
  May 2016 ,Medscape Medical News,Behavioral Therapy for ADHD: Recommendations Ignored?,Very young children with ADHD are still not being referred for behavioral therapy as first-line treatment despite current AAP recommendations to do so.
  May 2016 ,Medscape Medical News,Success With Stem Cell Transplant in Myasthenia Gravis ,Seven patients with severe myasthenia gravis who received autologous hematopoietic stem cell transplants have experienced long-term remission. 
  May 2016 ,News Alerts,"Impulse Control Problems Linked to Antipsychotic, FDA Warns",The FDA is warning of impulse control problems associated with the atypical antipsychotic aripiprazole.
  May 2016 ,Medscape Medical News,Single-Dose Drug Decreases Bone Loss in Newly Treated HIV,"A single dose of zoledronic acid given at the start of ART decreases bone loss over the course of 48 weeks in HIV, according to a small, single-center, proof-of-concept study."
  May 2016 ,Medscape Medical News,"Education, Reminders Reduce Risky Prescriptions for Elders","Education and electronic reminders can reduce the prescription of potentially inappropriate medication to older patients discharged from the emergency department, new research shows."
  May 2016 ,Medscape Medical News,Androgen Treatment Leads to Elongated Telomeres in Small Trial ,The phase 1-2 study showed such unexpectedly high efficacy from treatment with the sex hormone danazol that investigators ended the study early.
  May 2016 ,Medscape Medical News,ECT an Effective Treatment Option for Schizophrenia,"Electroconvulsive therapy may be an effective treatment option for patients with schizophrenia, new research suggests."
  May 2016 ,News Alerts,"Death Risk With Off-Label Oral Ketoconazole Use, FDA Warns ","Clinicians continue to prescribe ketoconazole tablets for skin and nail fungal infections, even though the FDA withdrew those indications in 2013 in light of the risk for liver damage and death."
  May 2016 ,Medscape Medical News,FDA Warns About Amputation Risk With Canagliflozin,UPDATED // The agency is investigating whether the twofold increase in amputations seen in an ongoing trial is attributable to the drug.
  May 2016 ,Heartwire from Medscape,"Midday Napping May Raise HTN Risk, Says Meta-analysis","Although noting several limitations, experts say this analysis of more than 112,000 individuals ""grabbed attention"" and ""provides food for thought""     for clinicians."
  May 2016 ,Heartwire from Medscape,LEADERS FREE: Adieu to Bare-Metal Stents for High-Bleed-Risk ACS," Bare-metal stents should not be used for high-bleeding-risk ACS patients undergoing PCI, the authors say, but left unanswered is whether dual-antiplatelet     therapy can be cut short with drug-eluting stents."
  May 2016 ,Reuters Health Information,"Polymer Temporarily Protects and Tightens Skin, Smoothes Wrinkles","Material made from a silicone-based polymer can mimic the properties of normal youthful skin and shows promise for improving appearance, treating dry skin, and providing ultraviolet protection, researchers report."
  May 2016 ,Medscape Medical News,APS Issues New Guidance on Medical Marijuana for Pain,With patients increasingly turning to herbal cannabis for chronic pain -- legally or not --  the American Pain Society white paper offers clinical guidance and strong suggestions on the need for more research.
  May 2016 ,Medscape Medical News,Promising Data With Ketamine in Chronic and Phantom Limb Pain,"The key to avoiding adverse effects with ketamine is to start at a low dose, says one clinician. "
  May 2016 ,Medscape Medical News,Lithium May Best Newer Drugs at Reducing Self-harm in BD,"In this study of more than 6500 bipolar disorder patients, lithium was better at reducing rates of self-harm and unintended injury compared with newer drugs commonly prescribed for this condition."
  May 2016 ,Medscape Medical News,CAM Use May Delay Chemotherapy in Breast Cancer,"Breast cancer patients with early-stage disease who use dietary supplements are less likely to initiate recommended chemotherapy, new research shows."
  May 2016 ,Heartwire from Medscape,"Falling, Serious Injury in Elderly Tied to Changes in BP Meds","Now there are data showing that after starting antihypertensive meds or raising their dosages, physicians should keep a closer eye on older patients to     make sure they tolerate the changes, say researchers."
  May 2016 ,News Alerts,"Limit Fluoroquinolone Use in Light of Risks, FDA Says","Clinicians should not prescribe these antibiotics to patients with uncomplicated infections such as sinusitis if there are other treatment options, the agency said."
  May 2016 ,Medscape Medical News,Giant Cell Arteritis: Ustekinumab Shows Activity in Early Trial,Ustekinumab was associated with lower steroid doses in some patients with GCA and reduced arterial wall thickening. 
  May 2016 ,Medscape Medical News,Vaccine Boosts Glioblastoma Survival,A novel combination of cytomegalovirus-targeted dendritic cell vaccine and tetanus preconditioning shows a significant increase in survival and improved immune response in glioblastoma.
  May 2016 ,Medscape Medical News,"Where Cancer Care Falls Short, According to Patients","Despite believing their medical care is excellent, US cancer patients often feel inadequately informed about a lot of things, according to new polling of 3000 adults with cancer. "
  May 2016 ,Medscape Medical News,Relapses Rebound in Patients With MS Stopping Fingolimod,"As seen with natalizumab, a new study shows patients may experience rebound in relapses after stopping fingolimod. "
  May 2016 ,Reuters Health Information,Proton Pump Inhibitors Accelerate Cellular Aging,A new study suggests that chronic use of a proton pump inhibitor (PPI) accelerates aging of endothelial cells.
  June 2016 ,Medscape Medical News,Benefits of Medical Marijuana May Outweigh Risks,"For pain, medical marijuana appears to be more effective than conventional medications, with few, and very minor, adverse effects, new research shows."
  June 2016 ,Medscape Medical News,Second-generation Antipsychotics: Not All Equal,A systematic review and meta-analysis of various second-generation antipsychotic agents in the treatment of first-episode psychosis finds that not all are created equal.
  June 2016 ,Medscape Medical News,ADHD Medication May Boost Kids' Arrhythmia Risk,"Children and young people prescribed methylphenidate, commonly used in ADHD, have an increased risk for arrhythmia in the weeks after initiation of treatment."
  June 2016 ,Medscape Medical News,High Prolactin Levels Signal Antipsychotic Toxicity,Monitoring prolactin levels in plasma is a way to accurately assess potential toxicity of antipsychotic medications in patients aged 55 years and older.
  June 2016 ,Medscape Medical News,What Will You Tell Breast Cancer Patients About MA-17R?,A major clinical trial indicates that 5 more years of an aromatase inhibitor in postmenopausal women yields a disease-free survival benefit as well as adverse events. Is the treatment worthwhile?
  May 2016 ,FDA Approvals,FDA Clears Obeticholic Acid for Primary Biliary Cholangitis,"The first new treatment in almost 20 years for the condition, Ocaliva is for use in combination with UDCA in adults with poor response to UDCA or as a single therapy in adults unable to tolerate UDCA."
  May 2016 ,FDA Approvals,FDA Approves Daclizumab (Zinbryta) for Multiple Sclerosis,The US Food and Drug Administration has approved daclizumab for treatment of patients with MS who are not responsive to other agents; the approval comes with a Risk Evaluation and Mitigation Strategy.
  May 2016 ,Medscape Reader Polls,Reader Poll: Are Fluoroquinolones Safe?,The FDA recently issued a warning about serious adverse effects after fluoroquinolone use. Will you continue to prescribe them to your patients? 
  May 2016 ,FDA Approvals,FDA OKs Buprenorphine Implant (Probuphine) for Opioid Dependence,The new buprenorphine subdermal implant could be 'game changer' in the battle to combat opioid use disorder.
  May 2016 ,Medscape Medical News,Antipsychotic-Related Metabolic Testing Falls Far Short,"Although rates of annual glucose testing among adults prescribed antipsychotics are high, fewer than half of patients undergo lipid testing, an analysis of Medicaid data suggests."
  May 2016 ,Medscape Medical News,Mindfulness Therapy May Prevent Depression Relapse,"Mindfulness-based cognitive therapy substantially reduces the risk for relapse in patients with recurrent depression, a new meta-analysis confirms."
  May 2016 ,Medscape Medical News,Benzodiazepines Are Often Inappropriately Prescribed,"Although the drugs have known adverse effects for people with depression, 52% of prescriptions, which often come from primary care physicians, were concurrent with prescriptions for antidepressants."
  May 2016 ,Medscape Medical News,FDA Panel OKs Sanofi Insulin-GLP-1 Combo for Diabetes,The committee was concerned about the pen injectors used to deliver the medication as well as the potential for allergic reactions.
  May 2016 ,Medscape Medical News,Economic Crisis of 2008 Followed by Excess Cancer Deaths  ,"An analysis of data from 75 countries shows an increase of cancer deaths, particularly in countries without universal healthcare coverage.  "
  May 2016 ,Medscape Medical News,Gastric Endoscopic Myotomy Showing Promise for Gastroparesis,"For patients with refractory disease, gastric peroral endoscopic myotomy (G-POEM) can reduce hospitalizations, improve symptoms, and normalize gastric emptying time, early research suggests."
  May 2016 ,WebMD Health News,NICE Recommends Three Diabetes Treatments,The National Institute for Health and Care Excellence (NICE) is issuing guidance recommending three existing drugs as individual treatments for type 2 diabetes.
  May 2016 ,Medscape Medical News,"FDA Panel Backs Novo Nordisk Insulin-GLP-1 Combination, IDegLira ",The committee said that it was uncertain about which patients would most benefit from the combination.
  May 2016 ,Medscape Medical News,Pregabalin Linked to Major Birth Defects,"Exposure to pregabalin, an antiepileptic also prescribed for pain and psychiatric disorders, during pregnancy is linked to a 3-fold increased risk for major birth defects, a new study suggests."
  May 2016 ,State Health Alerts,Lyme and Other Tickborne Diseases in New Hampshire ,New Hampshire continues to have one of the highest rates of Lyme disease in the nation. The state's Division of Public Health Services provides advice on diagnosis and treatment.
  May 2016 ,Reuters Health Information,Skin Cancer Patients Face Deadly Risk Using 'Black Salve' Home Remedy,"People who fear they have skin cancer, or know it, and decide to try an unapproved product called ""black salve"" may face infection, scarring and worse cancer outcomes, doctors warn."
  July 2016 ,Medscape Medical News,New Neurotoxicity From Immunotherapy for Advanced Melanoma?,Two cases of severe demyelinating polyradiculoneuropathy linked to pembrolizumab prompt calls for increased awareness of this 'devastating' complication.
  July 2016 ,Medscape Medical News,Should Patients Get a Money-Back Guarantee?,"One major health system is giving the radical idea a try. So far, one executive sees it as a positive 'disruption' -- another calls it 'nutty.'"
  July 2016 ,Reuters Health Information,Lichenoid Features Tied to Cancer Immunotherapy Skin Problems,"Skin eruptions in cancer patients due to use of antagonist antibodies to programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) show lichenoid features on histologic analysis, according to a small case series."
  July 2016 ,Medscape Medical News,FDA Panel Backs Approval of Psoriasis Drug Brodalumab,The panelists said that patients should be given proper informed consent about the risk for suicide. 
  July 2016 ,Heartwire from Medscape,"Avoiding Meds That Worsen, Cause HF: AHA Presents Action Plan","Though geared for heart failure patients of all ages, the AHA's new statement, ""implicates almost every   medication most older patients are taking,"" says one expert."
  July 2016 ,Heartwire from Medscape,"Variable LDL-C Tied to Worse Memory-Test Scores, MRI Findings","The study adds to ""emerging evidence that vascular factors are of importance to brain health and underscores that LDL-C variability might be a useful risk marker,""   the lead author says."
  July 2016 ,Medscape Medical News,Experts Warn Against DIY Brain Stimulation ,"In response to reports of the general public using 'do-it-yourself' transcranial electrical stimulation to 'zap themselves smarter,' several experts have warned of the possible dangers of this practice  "
  July 2016 ,News Alerts,EMA Begins Review of Retinoid Drugs,An EMA committee has begun a review of retinoids because of concerns about the adequacy of pregnancy prevention programs and product information regarding the risk for neuropsychiatric disorders.
  July 2016 ,FDA Approvals,FDA Approves First OTC Retinoid (Differin Gel 0.1%) for Acne,The product contains the first new active ingredient for OTC acne treatment since the 1980s.
  July 2016 ,News Alerts,PRAC to Review Risks of Modified-Release Paracetamol,The agency will consider measures to minimize risk and reduce harm of overdose with modified- and prolonged-release paracetamol products.
  July 2016 ,Medscape Medical News,"Bring Back HPV Vaccination, Say Japanese Experts","The Japanese government withdrew its recommendation for the HPV vaccine because of concern over side effects, but some physicians are urging the government to reconsider."
  July 2016 ,Medscape Medical News,Novel Cancer Weight-loss Drugs Needed to Improve Outcomes,"Medications to tackle cachexia in cancer patients that reflect recent breakthroughs in our understanding of the pathological process are needed, say         palliative care experts.     "
  June 2016 ,Reuters Health Information,Gastric Bypass Superior to Medical Management of Diabetes But With Side Effects,"Gastric bypass is more effective than lifestyle-medical management alone in achieving diabetes treatment goals, but the effect of surgery diminishes over time and is associated with more adverse events, researchers report."
  June 2016 ,Medscape Medical News,Checkpoint Inhibitors Linked to Inflammatory Arthritis,"Inflammatory arthritis and sicca syndrome have been reported with ipilimumab and/or nivolumab, and the conditions can persist after stopping therapy."
  June 2016 ,Medscape Medical News,Antidepressants Have a Role to Play in Schizophrenia,A review of adjunctive antidepressants in schizophrenia shows these agents have a role to play in patients with predominantly negative or depressive symptoms.
  June 2016 ,Medscape Medical News,Guidelines Updated on Pediatric Sedation,The American Academy of Pediatrics and the American Academy of Pediatric Dentistry have issued updated guidelines on pediatric sedation.
  June 2016 ,International Approvals,Cell-Based Therapy for Transplant Patients Gets OK in Europe,A novel product that consists of T cells has been recommended for conditional approval for use in stem cell transplant patients in Europe.
  June 2016 ,Medscape Medical News,Second-Generation Antipsychotics Offer Better Quality of Life,Schizophrenia patients taking a second-generation drug reported better quality of life compared with those taking first-generation agents.
  June 2016 ,Heartwire from Medscape,Ticagrelor Stopped by Many Stable Patients With Prior MI,"Discontinuation was seen mostly in the first year of treatment and emphasizes that ""patients may make decisions about treatment without telling their physician or     acknowledging adverse events,"" caution researchers."
  June 2016 ,Medscape Medical News,Can Patients Discontinue Immunotherapy and Still Benefit?,"Overall, there are few data on whether to and when to discontinue immunotherapy, but clues from trials show continued benefit."
  September 2016 ,Medscape Medical News,AAP: Stop Giving Codeine to Children,The American Academy of Pediatrics urges parents and healthcare providers to stop giving codeine to children and calls for formal restrictions on its use. 
  September 2016 ,Medscape Medical News,Vaccine Maverick 'Dr Bob' Sears Accused of Negligence,"Known for his alternative childhood vaccination schedules, Dr Sears could lose his license in a case brought by the California medical board."
  September 2016 ,Medscape Medical News,DCIS Score Fails Cost-Effectiveness Test,The Oncotype DX DCIS Score was not cost-effective in any of five different treatment strategies that were analyzed.
  September 2016 ,Medscape Medical News,FDA Questions Validity of Smoking Cessation Drug Research,The FDA has raised concerns about a postmarketing study that examined adverse neuropsychiatric events associated with smoking cessation drugs varenicline and bupropion.
  September 2016 ,Medscape Medical News,Novel SGLT Inhibitor Adds Benefit to Insulin in Type 1 Diabetes,"A study design includes ""optimized"" insulin to demonstrate additional benefit for sotagliflozin, but the safety profile may be an issue and ""awaits further     results."""
  August 2016 ,Kaiser Health News,'America's Other Drug Problem': High Volume of Prescriptions for Elderly,"Older people are often given a huge number of medications, and many of them are unnecessary or even harmful."
  August 2016 ,Medscape Medical News,Fingerprints Disappear During Capecitabine Therapy ,"The commonly used chemotherapy agent capecitabine can leave many patients without fingerprints, but the effect is temporary."
  August 2016 ,Heartwire from Medscape,Optical Coherence Tomography: Modest Benefit in PCI,"The imaging technology was not associated with adverse effects, despite increasing PCI procedural time and contrast-media exposure in the DOCTORS study.   "
  August 2016 ,Medscape Medical News,Metformin Mitigates Antipsychotic Weight Gain in Autism,A study finds metformin effective in decreasing weight gain associated with atypical antipsychotic use in children and adolescents with autism spectrum disorder.
  August 2016 ,WebMD Health News,EpiPen Price Hikes: What to Know,The rising cost of a life-saving allergy drug dispenser is raising eyebrows at the pharmacy counter and on Capitol Hill.
  August 2016 ,Medscape Medical News,"Oral Contraceptives Don't Impair Sexual Function, at Least Overall","Still, use of a levonorgestrel-based contraceptive in a trial had modest but significant adverse effects on measures of arousal and pleasure, and ""for     individual women, we believe it could be of clinical importance."""
  August 2016 ,Medscape Medical News,Spotting Psychosis Linked to AEDs in Epilepsy,"The identification of antiepilepsy drug-induced psychotic disorders among epilepsy patients may become easier after the identification of several associated factors, say Australian researchers."
  August 2016 ,Medscape Medical News,Vancomycin in Cataract Procedures May Cause Blindness,Researchers have documented 35 eyes with severe hemorrhagic occlusive retinal vasculitis after treatment with vancomycin during cataract procedures.
  August 2016 ,Medscape Medical News,FDA: 'Unique' Toxicity With Failed French Drug   ,"The investigational FAAH inhibitor BIA 10-2474 exhibits a unique toxicity that does not extend to other drugs in the class, the FDA has concluded. "
  August 2016 ,Medscape Medical News,Can Chemotherapy Affect Developing Ovaries in Female Fetus?,Experimental data suggest that chemotherapy given during pregnancy could affect ovary development in the fetus.
  August 2016 ,Medscape Medical News,Counterfeit Alprazolam Poses a 'Major Public Health Threat',Counterfeit alprazolam tablets containing the highly potent opioid fentanyl have been behind a series of cases of central nervous system depression and death in California.
  August 2016 ,Medscape Medical News,"Transdermal Buprenorphine May Ease Neuropathic Pain, With Caveat"," For diabetes patients with moderate-to-severe neuropathic pain, those who can tolerate the treatment often experience significant relief."
  July 2016 ,Medscape Medical News,"Parents' Vaccine Acceptance Continues to Rise, Clinicians Say","A comparison of the 2016 and 2015 Medscape surveys on vaccine acceptance shows that the increase last year wasn't a temporary boost from reaction to the California measles outbreak. Still, more than 1 in 3 clinicians see no gains."
  July 2016 ,Medscape Medical News,Class Action Lawsuit Against HPV Vaccine Filed in Japan,The class action lawsuit has 63 plaintiffs claiming a wide range of health problems that they say developed after receiving the HPV vaccine. 
  July 2016 ,News Alerts,Fluoroquinolone Label Warning Strengthened by FDA,"The FDA updated fluoroquinolone labeling to warn against routine use in patients with acute bacterial sinusitis, acute exacerbation of chronic bronchitis, and uncomplicated urinary tract infections.  "
  October 2016 ,Reuters Health Information,Post-Finasteride Syndrome Not Related to Androgen Deficiency,"Men who report persistent sexual symptoms after using finasteride for hair loss do not show abnormalities in androgens or their receptors, according to a new report."
  October 2016 ,Reuters Health Information,Methotrexate Helpful in Some With Laryngotracheal Stenosis,"In patients with rapidly recurrent nonvasculitic laryngotracheal stenosis (LTS), low-dose methotrexate may be an effective adjunct to surgery, researchers say."
  October 2016 ,Medscape Medical News,Antidepressants Worsen Sexual Dysfunction and Depression?,"Currently available antidepressants that lead to sexual problems may make depression worse, results of a new survey show."
  October 2016 ,Medscape Medical News,Micronutrient Deficiency Often Unnoticed in PPI Users,"Proton pump inhibitors (PPIs) raise the risk for micronutrient deficiency, but clinicians rarely check for it, a small study warns."
  October 2016 ,Medscape Medical News,New Antipsychotic Effective With Placebo-like Side Effects,Several positive studies support pursuit of approval for a first-in-class antipsychotic with efficacy comparable to that of current medications but with a placebo-like side effect profile.
  October 2016 ,Medscape Medical News,Nivolumab Ups Quality of Life in Head and Neck Cancer Pts,"Patients with advanced head and neck cancer who have progressed following first-line treatment have stable or improved symptoms and function with nivolumab immunotherapy, phase 3 trial data reveal."
  October 2016 ,Medscape Medical News,"SSRIs Disrupt Sleep in the Elderly, May Contribute to Dementia","Antidepressants, especially SSRIs, can significantly disrupt sleep architecture in elderly patients and may contribute to early neurodegeneration that can progress to dementia, new research shows."
  October 2016 ,Medscape Medical News,Drug Cuts Tardive Dyskinesia in Psychiatric Patients,Valbenazine reduces the severity of tardive dyskinesia and works in both psychotic patients and those with mood disorders with no risk for psychiatric instability during the course of treatment.
  October 2016 ,Reuters Health Information,Herbal and Dietary Supplements Tied to Liver Damage,"One in five cases of chemical-induced liver damage come from herbal and dietary supplements, a research review concludes."
  October 2016 ,Medscape Medical News,Suboptimal Reporting of Adverse Events in Pivotal Cancer CTs,Many FDA-approved trials for treatment of advanced cancers had suboptimal reporting for recurrent and late toxicities and duration of AEs.
  October 2016 ,Kaiser Health News, Pricey New Treatment Roils Issues of How to Treat Prostate Cancer,"High-intensity focused ultrasound, often not covered by insurance, leads to discussions about which patients benefit in the real world. "
  October 2016 ,Medscape Medical News,Hypnotics Linked to Increased Suicide Risk,"Hypnotic medications such as benzodiazepines may be linked to an increased risk for suicide and suicidal ideation, although the impact of comorbid depression and substance use remains unclear."
  October 2016 ,Medscape Medical News,New FDA Watch List Covers 27 Drugs and Drug Classes,The quarterly list of drugs and unexpected adverse events includes treatments for disorders ranging from diabetes and depression to multiple sclerosis and hypertension.
  October 2016 ,News Alerts,"HCV Drugs May Reactivate HBV, FDA Warns",A boxed warning for nine direct-acting antiviral drugs for HCV advises clinicians to screen for current or prior HVB infections.
  September 2016 ,Reuters Health Information,New Tenofovir Formulation Provides Safer Hepatitis B Treatment,"A new prodrug formulation, tenofovir alafenamide, effectively treats chronic hepatitis B virus (HBV) infection with fewer bone and renal adverse effects than tenofovir disoproxil fumarate, according to two noninferiority trials."
  September 2016 ,Medscape Medical News,Is IMRT for Gynecologic Cancers Less Toxic?,Pelvic IMRT reduces acute patient-reported toxicity compared to standard pelvic radiation therapy.
  September 2016 ,Medscape Medical News,Lenvatinib: 'Real-World' Therapy for Differentiated Thyroid Cancer ,The first reports of the drug outside of the clinical trial setting show efficacy but early side effects.
  September 2016 ,Heartwire from Medscape,Statin Safety Claims in Lancet Reignite Acrimony,"The statin review is being cast as more than yearlong effort to set the record straight regarding the safety and efficacy of statin therapy and at the same time ""a total whitewash."""
  September 2016 ,News Alerts,"Emergency Contraceptives Affected by Other Medications, UK Warns",The UK's version of the FDA is warning that emergency contraceptives may not work properly when combined with certain other common medications.
  September 2016 ,Medscape Medical News,Adverse Effects Underreported in Clinical Trials,"Adverse effects of medical treatments appear to be underreported in peer-reviewed journal articles that describe clinical trial results, a new systematic review has found."
  December 2016 ,Medscape Medical News,Dual VA and Medicare Use Tied to Risky Prescribing ,"Policies that allow veterans to use both Veterans Affairs facilities and other healthcare systems exposed patients with dementia to potentially harmful drug prescribing, a new study has found."
  November 2016 ,Medscape Medical News,"Don't Rush to Ban or Use Kratom, Expert Says","A new review contends the herbal remedy kratom has some beneficial properties, suggesting a Drug Enforcement Administration proposal to make it illegal could bring legitimate research to a standstill."
  November 2016 ,Medscape Medical News,MEK Inhibitors Linked to Ocular Adverse Effects,"MEK inhibitors appear to be associated with a risk for ocular side effects, and patients should be monitored."
  November 2016 ,Medscape Medical News,What's Hot at ASH 2016 Meeting? ,New data to be presented at the upcoming American Society of Hematology (ASH) annual meeting will likely change clinical practice for some patients with lymphoma.   
  November 2016 ,News Alerts,"Recall of Cantrell, Tri-Coast Drugs for Sterility Concerns",Concerns about lack of sterility have led Cantrell Drug Company and Tri-Coast Pharmacy to recall numerous lots of drug products used for various indications.
  November 2016 ,Medscape Medical News,"Cannabis Helpful for Drug Addiction, Mental Health Disorders?","A new review suggests cannabis may be useful in the treatment of substance use disorders and anxiety disorders, particularly PTSD. However, more research is needed."
  November 2016 ,Medscape Medical News,ED Visits for Adverse Drug Reactions Common and Rising,"Four of every 1000 individuals will go to the emergency department for an adverse drug reaction each year, and that number is rising in older adults, a new study has found."
  November 2016 ,Medscape Medical News,Ustekinumab Effective in TNFi-Refractory Crohn's Disease,"Ustekinumab induced early response and sustained remission at 44 weeks significantly better than did placebo, with a similar side effect profile, three trials have found."
  November 2016 ,Medscape Medical News,"New Standard in ER+ Breast Cancer, but How to Proceed?","Palbociclib improves progression-free survival in advanced disease to an unprecedented degree, but does that mean it should automatically be used in every patient?"
  November 2016 ,Medscape Medical News,Prescribers Have Poor Understanding of Penicillin Allergy,"Inpatient healthcare providers who prescribe medications have little understanding of when to consult an allergist about a documented penicillin allergy, a new survey shows."
  November 2016 ,News Alerts,FDA Approves Boxed Warning for Essure,The new label for the permanent contraceptive device highlights possible adverse events such as perforation of the uterus or fallopian tubes.
  November 2016 ,Medscape Medical News,Questioning Ethics of Costly Drugs for Metastatic Cancer,"Spending a six-figure sum to prolong a life by a few weeks or months is unaffordable and is inappropriate for many patients, argues a UK clinician."
  November 2016 ,Medscape Medical News,Testing Penicillin Allergy Cuts Wide-Spectrum Antibiotic Use,"Hospitals can substantially reduce the use of beta-lactam antibiotics in patients at high risk for infection by screening to verify penicillin allergy, new research shows."
  November 2016 ,Medscape Medical News,"Off-Label Drug, Medical Device Use Discussed at FDA Hearing",The FDA held a 2-day public hearing to solicit input about the marketing and use of medications and medical devices for off-label use.
  November 2016 ,FDA Approvals,FDA Clears Tenofovir Alafenamide (Vemlidy) for Chronic HBV,"Once-daily Vemlidy has similar efficacy to tenofovir disoproxil (Viread) with fewer bone and renal side effects, the company says."
  November 2016 ,Medscape Medical News,Childhood Cancer Survivors Continue to Report Poor Health,Childhood cancer survivors treated in a more modern era of cancer care still report equal levels of perceived ill health as those treated in a much earlier era despite receiving less toxic therapy.
  November 2016 ,Medscape Medical News,Fatal Myocarditis -- Rare New ADR With Immunotherapy,Fatal myocarditis has been reported in melanoma patients treated with ipilimumab and nivolumab; this appears to be a rare T-cell-driven reaction.
  November 2016 ,Medscape Medical News,More Information on Adverse Effects in Tragic French Trial,Clinical details on four of the volunteers who received the drug that caused severe neurologic reactions -- including death in one case -- have now been published in NEJM. 
  October 2016 ,Medscape Medical News,'Unprecedented' Rise in Pediatric Opioid Poisonings,"Hospitalizations for pediatric opioid poisonings rose sharply from 1997 to 2012, and the largest increase was among toddlers and preschoolers, a new study has found."
  October 2016 ,News Alerts,"FDA Recommends Boxed Warning, Decision Guide for Essure","The boxed warning should list adverse events that may be associated with the device, and the decision guide should be signed by patient and provider."
  February 2017 ,Medscape Medical News,Questions Over Adjuvant Ipilimumab in Melanoma,"An editorial raises questions on data for patient-reported outcomes for adjuvant ipilimumab, 10 mg/kg, in melanoma; toxicity also questioned. "
  February 2017 ,Medscape Medical News,"Some Stop Immunotherapy, Still Have Controlled Cancer","In a small study of patients with advanced renal cell carcinoma, nearly half had durable responses after discontinuing checkpoint inhibitors because of toxicities."
  February 2017 ,Medscape Medical News,"Air Pollution 'a Catalyst' for Obesity, Diabetes in Children"," ""Poor air quality appears to be a catalyst for obesity and diabetes in     children,"" conclude authors of a study finding a role for exposure to air     pollution in the etiology of type 2 diabetes in youth."
  February 2017 ,Medscape Medical News,Why the FDA Took 23 Years to Warn About Morcellators,"Power morcellators can spread occult uterine cancer, but manufacturers, hospitals, and physicians didn't start telling the FDA about such mishaps until an injured patient did so more than 2 decades after the first device was approved."
  February 2017 ,News Alerts,"PRAC: Selexipag Under Review, Starts Antibiotic Safety Review","PRAC advises continued use of selexipag (Uptravi), on the basis of preliminary data review; launches review of long-lasting side effects with quinolone and fluoroquinolone antibiotics. "
  February 2017 ,News Alerts,FDA: Chlorhexidine Gluconate May Cause Allergic Reactions,An increase in reports of serious allergic reactions to OTC skin antiseptic products containing chlorhexidine gluconate prompts safety alert from FDA and a request that manufacturers update labels.
  February 2017 ,Heartwire from Medscape,One Way e-Cigarettes May Up CV Risk: Altering HR Variability,Questions for the future: Are their cardiac risks as great as those from tobacco cigarettes? Which components of e-cigarette aerosol are driving their adverse physiological effects?
  February 2017 ,Medscape Medical News,Dimethyl Fumarate for MS: Liver Injury Warning Strengthened,The prescribing information for the oral medication has been updated to include a warning of potential liver injury that could require hospitalization.
  January 2017 ,Medscape Medical News,Severe Side Effects Higher Than Expected in Breast Cancer ,Study found that almost half of women treated for early-stage invasive breast cancer experience severe or very severe side effects.    
  January 2017 ,Reuters Health Information,Ferric Citrate Improves Iron-Deficiency Anemia in Chronic Kidney Disease,"Oral treatment with ferric citrate improves iron-deficiency anemia in patients with non-dialysis-dependent chronic kidney disease (NDD-CKD), according to a randomized controlled trial."
  January 2017 ,Medscape Medical News, Blocking Peripheral Cannabinoid Receptors Cuts Gorging -- in Mice," CB1-receptor antagonists that don't cross the blood-brain barrier may be     useful to treat metabolic syndrome, without the harmful psychiatric side     effects seen with rimonabant, preclinical work suggests."
  January 2017 ,Medscape Medical News,Europe Clears Tenofovir Alafenamide (Vemlidy) for Chronic HBV,"The efficacy of once-daily Vemlidy is similar to that of tenofovir disoproxil (Viread) with fewer bone and renal side effects, the company says."
  December 2016 ,Medscape Medical News,Marijuana Use Jumps in Pregnant Women,"More pregnant women in the US are using marijuana than ever before, prompting experts to warn that such use could lead to adverse outcomes for mothers and infants."
  December 2016 ,Medscape Medical News,Psychiatry News Quiz 2016: Test Your Smarts,"Re-emergence of research into psychedelics for mental illness, doctors gone bad and MACRA's potential impact on incomes were among the most read stories by psychiatrists this year. Test your news knowledge."
  December 2016 ,Medscape Medical News,VPT for Low-Risk Prostate Cancer: 'Huge Leap Forward',Vascular-targeted photodynamic therapy (VPT) involves a light-sensitive drug activated with a laser to destroy tumor tissue in the prostate.
  December 2016 ,Medscape Medical News,Bendamustine Toxicity in FL Raises Eyebrows -- and Questions,Results from the GALLIUM study in follicular lymphoma (FL) showed that fatal toxicity was higher with bendamustine compared with other regimens. What does this mean for clinical practice?
  December 2016 ,Medscape Medical News,FDA Smokes Black Box Warning on Chantix,"Siding with an advisory committee, the FDA approved dropping the black box warning regarding possible serious neuropsychiatric side effects with Pfizer's smoking cessation drug varenicline."
  December 2016 ,Medscape Medical News,First-Ever RCT: Cold Cap Works for Chemo Hair Loss,Hair loss from chemotherapy is often cited as traumatizing by breast cancer patients; a first-ever randomized clinical trial shows that a scalp-cooling device helps.
  December 2016 ,WebMD Health News,What Your Patients Searched for Most in 2016,The Zika virus surprised everybody in 2016 and sent people searching for more information about its symptoms and how to prevent it. Surprising side effects of common medications and high drug prices also earned spots on the list of year's top searches.
  December 2016 ,Medscape Medical News,Immunotherapy Looks 'Promising' in Malignant Mesothelioma,Immunotherapy with nivolumab and pembrolizumab could offer hope to patients with malignant mesothelioma: new studies show improved progression-free survival.
  May 2017 ,Heartwire from Medscape,Muscle Pain Reported Mostly by Those Aware They're on Statins,"Attribute most reported muscle pain on statins to the power of suggestion, says a new analysis of a decade-old trial. An observer says the truth is in middle: often it's a nocebo effect, often it's real."
  May 2017 ,Medscape Medical News,Long-term Symptoms in Cervical Cancer Survivors,"Long-term cervical cancer survivors frequently suffer from treatment-related side effects, which can greatly affect their quality of life."
  May 2017 ,Medscape Reader Polls,Should You 'Fire' a Patient for Refusing Vaccines?,More physicians are taking a stronger stance against vaccine-refusing patients. What do you think?
  April 2017 ,News Alerts,"Don't Use Tramadol and Codeine in Kids Under 12, FDA Warns",The two opioids pose the risk for potentially fatal respiratory depression in young children. The FDA also is restricting their use in older children.
  April 2017 ,Medscape Medical News,Even Short-term Oral Steroids Carry Serious Risk,"A large, population-based study found a significantly higher rate of acute adverse events such as sepsis, venous thromboembolism, and fracture, even after a low-dose, short-term steroid treatment."
  April 2017 ,Medscape Medical News,Ten Drugs Make New FDA Watch List,Some of the adverse events observed for the cited drugs already have been put to regulatory rest.
  March 2017 ,Medscape Medical News,New Insomnia Med a Safer Option for Older Adults?,"The insomnia drug suvorexant appears to be safe and effective in older adults, without some of the risks and side effects commonly associated with of other pharmaceutical agents, new research suggests."
  March 2017 ,Medscape Medical News,No Consensus for Discontinuing Mainstay Alzheimer's Drugs,"Guidelines for initiating treatment of Alzheimer's symptoms with cholinesterase inhibitors are well established, but consensus as to when, how, and whether to discontinue treatment is lacking."
  March 2017 ,Medscape Medical News,Tailor Prostate Cancer Tx by Adverse Effects Profile,"Prostate cancer treatments are all associated with distinct adverse effects profiles, and these can be used to individualize treatment decisions for localized disease."
  March 2017 ,News Alerts,FDA: Avoid IBS Drug Viberzi in Patients With No Gallbladder,Patients without a gallbladder have an increased risk for serious pancreatitis when taking eluxadoline. 
  March 2017 ,Medscape Medical News,Decade-Long Benefit With Sulfonylureas in Rare Genetic Diabetes,"Sulfonylureas can be used to treat a rare form of gene-associated diabetes for at least 10 years, with good glycemic control and no serious adverse events, say UK researchers. "
  March 2017 ,Medscape Medical News,'Imatinib Changed Everything': The Future Is Now More Hopeful,"The development in the 1990s of this oral drug that targets a driver mutation 'fundamentally altered the field of oncology,' says an NEJM editorial."
  March 2017 ,Medscape Medical News,Muscle Composition Metric May Help Predict Chemo Toxicity,An experimental metric that measures muscle composition may be able to predict which patients are most likely to experience chemotherapy-related side effects.
  March 2017 ,Medscape Medical News,Neurofeedback Promising in Chemotherapy-Induced Neuropathy,"Neurofeedback attenuates pain and unpleasantness of chemotherapy-induced peripheral neuropathy compared with usual care, and has virtually no side effects."
  March 2017 ,Medscape Medical News,Ocrelizumab Not Linked to Serious Infection Risk in MS,"Further OPERA and ORATORIO results show similar or even lower rates of severe infection in patients receiving the study drug vs interferon or placebo, researchers say, as well as better patient-reported outcomes. "
  February 2017 ,Medscape Medical News,Another AE Identified With Checkpoint Inhibitors ,"Add connective tissue diseases, such as Sjogren's syndrome, to the list of immune-related adverse events that can develop during cancer treatment with immune checkpoint inhibitors."
  February 2017 ,Heartwire from Medscape, Statin-Related Factors Predict High LDL-C Post-Coronary Hospitalization,"The key targets for interventions to improve LDL-C are prescription of and     adherence to sufficiently potent statins and notice of side effects, not     psychosocial or socioeconomic factors, the authors say."
  February 2017 ,International Approvals,EU Panel Likes Novel Targeted Lung Cancer Combo,The European panel has recommended for approval a targeted therapy combination for lung cancer with BRAF mutations and a treatment for chemotherapy-induced nausea and vomiting.
  February 2017 ,Reuters Health Information,Fewer Skin Side Effects With Accelerated Partial Breast Irradiation,"Accelerated partial breast irradiation (APBI) with interstitial brachytherapy may be an alternative to whole-breast irradiation (WBI) for some patients, according to five-year results from the GEC-ESTRO trial."
  June 2017 ,Medscape Medical News,SGLT1/2 Inhibitor Sotagliflozin 'Encouraging' in Type 1 Diabetes,"The investigational, oral agent sotagliflozin, a first-in-class, oral dual inhibitor of both SGLT1 and SGLT2, is in phase 3 trials in type 1 diabetes; results are promising but there are some caveats."
  June 2017 ,Medscape Medical News,Spasticity Drug Cuts Alcohol Consumption in High-Risk Drinkers,"Primary care patients with high-risk alcohol consumption have significantly better rates of low-risk drinking or abstinence with baclofen vs placebo, the results of a French study indicate."
  June 2017 ,Medscape Medical News,Value of Opioid Antagonists for Withdrawal Uncertain,"Combining an opioid antagonist with an adrenergic agonist is feasible for managing opioid withdrawal, but it's unclear whether this approach is better than an adrenergic agent alone."
  June 2017 ,News Alerts,Clindamycin Recalled as Sterility Problems Dog Hospira,"Earlier this year, the FDA faulted the drug maker for 'inadequate' oversight and control of its manufacturing processes at multiple plants."
  June 2017 ,FDA Approvals,FDA Approves New Epinephrine Prefilled Syringe,"Symjepi, from Adamis Pharmaceuticals, is for the emergency treatment of type I allergic reactions, including anaphylaxis."
  June 2017 ,Medscape Medical News,Antibiotic-Associated Adverse Events Common,"As many as 20% of hospitalized patients prescribed antibiotics experienced an adverse drug event, including Clostridium difficile or multidrug-resistant organism infection, a new study found. "
  June 2017 ,Heartwire from Medscape,"Quarter-Dose Combo Meds for HTN Effective, More Tolerated","A literature review suggests very low-dose multiple-drug regimens can lower blood pressure similar to standard-dose monotherapy, with fewer side effects."
  June 2017 ,Medscape Medical News,"New Drug Safe, Effective for Tardive Dyskinesia","Phase 3 trials showed improved movement and quality-of-life scores for deutetrabenazine-treated patients with tardive dyskinesia, leading the FDA to grant priority review and an August 30 target date."
  June 2017 ,Medscape Medical News,New Insight Into Off-Label Ketamine Use for Depression,"As the off-label use of ketamine for the treatment of severe depression soars, new research provides insight into the way clinicians are using it in the field, away from the research setting."
  June 2017 ,Medscape Medical News,Dacomitinib: Potential New EGFR Inhibitor for First-Line NSCLC,"The investigational second-generation EGFR inhibitor significantly prolonged PFS, but at a cost of higher toxicity compared to gefitinib."
  June 2017 ,Medscape Medical News,Is APHINITY the End of the Line for Trastuzumab Add-ons?,The addition of pertuzumab to standard trastuzumab therapy in patients with early HER2-positive breast cancer led to modest improvements and increased side effects in the APHINITY trial.
  May 2017 ,Medscape Medical News,"Underutilization of Clozapine 'Shameful, Embarrassing'"," Clozapine is underprescribed for schizophrenia because of concerns of adverse events and inadequate training. One expert says this underutilization ""is shameful and embarrassing"" for psychiatry."
  May 2017 ,News Alerts,"No Harm Seen in MRI Gadolinium Retention in Brain, FDA Says","Nearly 2 years of study yield no evidence of adverse events, but the FDA continues to recommend that clinicians use gadolinium-based contrast agents sparingly."
  May 2017 ,Medscape Medical News,Dopamine Agonists for Pituitary Tumors: To Treat or Not? ,"A novel use of medical therapy soon after surgery for nonfunctioning pituitary adenomas was up for debate, with strong arguments for and against changing the standard of care. "
  May 2017 ,Reuters Health Information,"Heart Problems Hit Hopes for Experimental Amgen, UCB Bone Drug",Amgen Inc and UCB SA no longer expect their experimental osteoporosis drug to win U.S. approval this year after a higher rate of serious heart-related side effects were observed in a late-stage clinical trial.
  May 2017 ,News Alerts,FDA: Fluoroquinolones Not Linked to Retinal Detachment,"Available evidence does not support reports that fluoroquinolone antibiotics may result in retinal detachment or aortic aneurysm or dissection, the FDA said. "
  May 2017 ,Medscape Medical News,Valbenazine Approval Highlights Lessons for Researchers,A New England Journal of Medicine editorial notes that the recent FDA approval of valbenazine for tardive dyskinesia shows how to effectively and quickly develop a much-needed treatment. 
  May 2017 ,Medscape Medical News,Safety Events Common in Newly Approved Drugs,More than 30% of new drugs approved by the FDA during a 10-year period are affected by a postmarket safety event.
  May 2017 ,Medscape Medical News,Prostate Cancer Patients Satisfied With HDR Brachytherapy,A single outpatient treatment with high-dose-rate (HDR) brachytherapy for prostate cancer was associated with low toxicity and high quality of life.
  May 2017 ,Medscape Medical News,Questions Over 'Flu Jab' in Lung Cancer Patients on PD Inhibitors ,"Patients with cancer receiving immune checkpoint inhibitors could be at increased risk for adverse events compared with the general population if they are given a yearly flu jab, say Swiss researchers.  "
  August 2017 ,Medscape Medical News,'Inadequate' Reporting of Ketamine Side Effects in Trials,"Active assessment, surveillance, and reporting of side effects during trials of ketamine for patients with depression are inadequate, new research suggests."
  July 2017 ,News Alerts,FDA Warns About Triamcinolone and Moxifloxacin Combo for Eye ,The FDA issued a safety alert after serious adverse events were reported in at least 43 patients who received a compounded triamcinolone and moxifloxacin product by intravitreal injection. 
  July 2017 ,Medscape Medical News,First-Episode Psychosis Drug Choice: No Clear Winner,"After first-episode psychosis, haloperidol should not be used, and the choice among second-generation antipsychotics should be guided by their side effect profile, new research suggests."
  July 2017 ,Reuters Health Information,Fear Keeps Many Eczema Patients From Using Steroid Creams,"Many people with eczema may avoid creams and ointments that can help ease symptoms like itching and inflammation because they’re afraid to try topical corticosteroids, a recent study suggests."
  July 2017 ,Medscape Medical News,"CV Events, Death Lower After Statin Rechallenge","Getting patients to stay on statins after an adverse reaction is getting harder though in the face of a growing ""cult"" of online antistatin sentiment, one expert says."
  July 2017 ,Medscape Medical News,Antipsychotics May Boost Outcomes in Refractory Depression,"Adding an antipsychotic to current antidepressant therapy may lead to better outcomes in treatment-refractory major depressive disorder, new research suggests."
  July 2017 ,Medscape Medical News,CDK Inhibitors in Breast Cancer: Manageable Toxicity Profile,CDK inhibitors represent a new treatment option in HR+ breast cancer. A new review article shows that their overall toxicity is low and can be adequately managed.
  July 2017 ,Medscape Medical News,'Incredibly Exciting': CAR T Cells as 'Living Drugs',"Unlike drugs that gradually disappear from the body, CAR T cells are 'living drugs' that persist in the body for years."
  July 2017 ,Medscape Medical News,ADHD Meds Tied to Lower Substance Abuse Risk,A new study provides more evidence that stimulants used to treat attention-deficit/hyperactivity disorder (ADHD) are unlikely to increase substance-related problems and may have a protective effect.
  July 2017 ,Medscape Reader Polls,Are You Concerned About Endocrine Disruptors?,Chemicals that disrupt hormones may lead to certain health problems you see in your practice. 
  July 2017 ,Medscape Medical News,FDA Advisory Board Gives Thumbs Up to Gemtuzumab for AML,"After being withdrawn from the market in 2010, gemtuzumab may once again be available as a frontline therapy for acute myeloid leukemia."
  July 2017 ,Medscape Medical News,Reassurance on Generic Lamotrigine Bioequivalence,"Two disparate generic formulations of lamotrigine were found to be bioequivalent to the branded product, Lamictal, in a new FDA-sponsored study."
  July 2017 ,Medscape Medical News,RCT: Menopause Symptoms Mistaken for Tamoxifen Side Effects,"Many women who use tamoxifen as a chemopreventive agent experience symptoms that are assumed to be drug related, but they may just be naturally occurring symptoms related to menopause."
  July 2017 ,Medscape Medical News,PPIs Linked With Higher Risk for Death," Use and duration of proton-pump inhibitors should be limited to medical indications, researchers say. An expert agrees but says the excess risk is small and the drugs are still often the best option. "
  July 2017 ,Medscape Medical News,New FDA Watch List Flags More Drugs,The agency spotted possible safety blips on its radar for 14 drugs or drug classes in the first 3 months of 2017.
  July 2017 ,Medscape Medical News,Penicillin Allergy in Children Substantially Overreported,"Many children with reported penicillin allergy are not actually allergic to the drug, a new study has found."
  June 2017 ,Medscape Medical News,Corneal Edema: Is Your Patient Receiving Amantadine?,"Amantadine-induced corneal edema, which can mimic a number of other ocular conditions, is best treated simply by discontinuation of the drug. "
  June 2017 ,Medscape Medical News,CAR T Cells Encouraging for Diffuse Large B-Cell Lymphoma,"Results from phase 2 studies of two anti-CD19 therapies for relapsed/refractory DLBCL show impressive responses, as well as adverse events that were 'reversible.'"
  June 2017 ,Reuters Health Information,Reports of Adverse Reactions With Cosmetics Increasing,Inflammatory arthritis is an underappreciated adverse event of immune checkpoint blockade that requires special management considerations.
  September 2017 ,WebMD Health News,Do Cold Meds Carry a Psychosis Risk?,Can common cold medication really make someone commit a violent and deadly crime?
  September 2017 ,Medscape Medical News,'Vote of Confidence for Sulfonylureas and Pioglitazone' in TOSCA IT,"""My bottom line is this is a vote of confidence for sulfonylureas and pioglitazone,"" said one expert. ""You could use these data to perhaps finesse which patients you might give them to."""
  September 2017 ,Medscape Medical News,Clear Benefit With Adjuvant Nivolumab in Resected Melanoma,"Adjuvant nivolumab significant improves relapse-free survival and reduces toxicity in comparison with ipilimumab in stage III/IV resected melanoma for patients at risk for relapse, trial results reveal."
  September 2017 ,Medscape Medical News,Neurologic AEs on Rise as Checkpoint Inhibitors Evolve,Potentially lethal immune-related adverse events (AEs) are expected to increase as anti-PD-1 therapies for solid tumors expand to include other cancers.
  September 2017 ,News Alerts,PharMEDium Recalls Oxytocin Products Because of Subpotency,"The recall covers all unexpired lots of oxytocin compounded with lactated Ringer's or lactated Ringer's and dextrose products produced between July 6, 2017, and August 29, 2017."
  September 2017 ,Medscape Medical News,ADA Updates Recommendations for Managing Hypertension in Diabetes," The recommendations include a treatment algorithm detailing specific lifestyle and pharmacologic approaches based on initial BP, renal sufficiency, response to therapy, and adverse effects."
  August 2017 ,FDA Approvals,FDA OKs Deutetrabenazine (Austedo) for Tardive Dyskinesia,The drug was also approved for chorea associated with Huntington's disease earlier in this year.
  August 2017 ,FDA Approvals,First CAR T-Cell 'Living Drug' Approved by FDA  ,"The first chimeric antigen receptor (CAR) T-cell therapy has been approved by the FDA for use in relapsed/refractory leukemia, for which it offers a 'paradigm shift.'"
  August 2017 ,Medscape Medical News,Final Word? Antidepressants 'Do Work',"Investigators are hoping a new 'mega-analysis' puts a final cap on the ongoing controversy over whether antidepressants, particularly selective serotonin reuptake inhibitors, are effective for depression."
  August 2017 ,Medscape Medical News,Anacetrapib REVEALs 'Modest' Effect on Cardiovascular Outcomes ,"Despite becoming the first CETP inhibitor to reduce outcomes in a major trial, whether the 9% reduction in events shown in REVEAL is enough for the drug to reach the market is being debated."
  August 2017 ,Medscape Medical News,"AKI Risk With SGLT2 Inibitors? Maybe Not, Clinic Data Show","Despite FDA warnings of a possible increased risk for AKI with the SGLT2 inhibitors, a new analysis of two large databases finds no evidence of elevated risk."
  August 2017 ,Medscape Medical News,Do TV Drug Ads Say Too Much About Risks? FDA Wants to Know,Recent research suggests that limiting the list of adverse events in DTC ads to the most important ones would help consumers better remember them.
  August 2017 ,Medscape Reader Polls,Do Your Patients Believe in Medical Conspiracy Theories?,"More than half of Americans say that big business and government is, in some way, conspiring against the health of the people."
  August 2017 ,Reuters Health Information,"Celecoxib May Be Safest Choice for Older, Chronic NSAID Users","The risk of major non-steroidal anti-inflammatory drug (NSAID) toxicity in older adults who take the drugs regularly is higher with naproxen and ibuprofen than with celecoxib, according to a new secondary analysis of PRECISION trial data."
  August 2017 ,Reuters Health Information,Inadvertent HPV Vaccination During Pregnancy Seems Safe,"Inadvertent human papillomavirus (HPV) vaccination in the periconceptional period or during pregnancy appears to have no adverse effects on women or their offspring, according to data from the Vaccine Safety Datalink."
  August 2017 ,News Alerts,FDA Warns Against Use of Any Liquid Product From PharmaTech,"Lab tests have found Burkholderia cepacia contamination in PharmaTech's oral liquid docusate products, which has been linked to recent patient infections."
  August 2017 ,Medscape Medical News,Class Action Lawsuit Against HPV Vaccine Filed in Colombia , An association representing 700 individuals who allege damage after receiving the human papillomavirus vaccine Gardasil has been launched in Colombia; a class action suit is ongoing in Japan.   
  August 2017 ,Medscape Medical News,Fear of Interactions May Affect Adherence in HIV+ Trans Women ,A study found that fear of interactions between hormone therapy and antiretroviral therapy may hinder medication adherence in transgender women with HIV; more research is needed on tailoring care to this group.  
  August 2017 ,Medscape Medical News,New Agent Promising for Negative Schizophrenia Symptoms,"In a phase 2b trial, treatment with the investigational agent MIN-101 led to an improvement in negative symptoms of schizophrenia."
  August 2017 ,Medscape Reader Polls,Do You Deprescribe?,Some physicians hesitate to take patients off medications for fear that the harms will outweigh the benefits.
  November 2017 ,Medscape Medical News,AE Risks With Combined Tx for Advanced Breast CA,"Individual targeted agents carry different degrees of risk for severe toxicities, but early management may prevent or reduce negative effect on quality of life."
  October 2017 ,News Alerts,PRAC Further Restricts Daclizumab (Zinbryta) in MS,"Because of risk for serious liver damage, daclizumab can be used only in specific patient groups, with 'strict liver monitoring,' the EMA committee has advised."
  October 2017 ,Kaiser Health News,So Much Care It Hurts,"A growing number of patients and doctors are concerned about overtreatment, which is rampant across the health care system."
  October 2017 ,Kaiser Health News,Cascade of Costs Could Push New Gene Therapy Above $1 Million,The costs of using a new class of cancer treatments include far more than the drug’s sticker price.
  October 2017 ,Medscape Medical News,Trump's Pick for Drug Czar Pulls Out After Investigation,The decision follows a report by the Washington Post and 60 Minutes that showed Rep. Tom Marino spearheaded legislation that made it harder for the government to police the pharmaceutical industry.
  October 2017 ,Medscape Medical News,Opioids Top List of Malpractice Claims Linked to Medications,"One problem is that some physicians cave into the requests of persuasive, pill-seeking patients against their better judgement, the medical liability insurer Coverys says in a new study."
  October 2017 ,Medscape Medical News,Immunotherapy Side Effects: New Global Guidelines for Nurses,"Immunotherapy has revolutionized cancer therapy, but these drugs have unique and sometimes life-threatening adverse events, as outlined in the new guidelines."
  October 2017 ,Medscape Medical News,Side Effects Skyrocket in France With Levothyroxine Reformulation ,"Merck is being pressured to make the previous formulation available, despite concerns and limited supplies. "
  October 2017 ,Medscape Medical News,Cancer Drugs Dominate New FDA Watch List,Making the list does not mean that the FDA has determined the drug causes the reported adverse event.
  October 2017 ,Medscape Medical News,Prescribing Pitfalls in Heart Failure With Comorbidities ,"Heart-failure patients often have chronic pain, diabetes, depression, or other med-intensive issues and may not even disclose what OTC drugs they're taking. Experts discuss prescribing cautions in these complex patients. "
  October 2017 ,Medscape Medical News,Right-to-Try Gains Steam as FDA Eases Compassionate Use,A House subcommittee considered two bills that would do an end run around an FDA program that makes experimental drugs available to the seriously ill.
  October 2017 ,News Alerts,FDA: Blindness Risk From Compounded Vancomycin Eye Injections,"The FDA is warning against intraocular injections of vancomycin either alone or in combination with other drugs, in light of a new case of hemorrhagic occlusive retinal vasculitis."
  September 2017 ,Medscape Medical News,Treatment That's Easy to Swallow in HPV+ Throat Cancer,"The radiation therapy dose for throat cancer was cut 50%, but the 2-year outcomes are still excellent, including no injury to patient swallowing."
  September 2017 ,Medscape Medical News,Cardiac Effects of Fingolimod in MS Reversible,"Fingolimod, used to treat multiple sclerosis, dampens cardiac autonomic modulation at rest and during challenges, but this effect appears to be reversible after discontinuation of the drug, a study shows."
  September 2017 ,Medscape Medical News,Antidepressants Tied to a Significantly Increased Risk for Death,A new meta-analysis shows a 33% increased risk for death with antidepressant use in the general population.
  September 2017 ,Medscape Medical News,"Montelukast Tied to Psychiatric Adverse Events in Kids, Adults","A review of voluntary adverse event reports found that asthma medication montelukast was linked to increased reports of depression and nightmares in adults and children, and aggression in children. "
  September 2017 ,Medscape Medical News,New Guidelines for Managing CAR T-Cell Acute Toxicities,Researchers at MD Anderson have developed a framework to help recognize and manage unique acute toxicities associated with CAR T-cell therapy.
  September 2017 ,Medscape Medical News,Do Tattoos Raise the Risk for Cancer?,"Components of the ink in tattoos migrate from the skin to the lymph nodes, leading to chronic enlargement, but the health risk has yet to be determined."
  September 2017 ,Medscape Medical News,Potentially Inappropriate Meds Common in Home Health Patients ,"A high prevalence of potentially inappropriate medication use among Medicare home health nursing patients puts this population at significantly increased risk for hospitalization, a study found."
  September 2017 ,Medscape Medical News,"Experts Still Confounded by How to Prevent, Manage Hypoglycemia","Clinicians, advocates, and federal officials said the pressing public-health problem of hypoglycemia should be considered an outcome, not a side effect, and noted it can occur outside of diabetes."
  January 2018 ,Medscape Medical News,"Antibiotics, Antidepressants Dominate New FDA Watch List","Presence on list does not mean a drug has been linked to a risk, only that new safety information is available or potential risk has been identified and further review will be or has been completed."
  January 2018 ,Medscape Medical News,Heated Intraperitoneal Chemo for Ovarian Cancer Ups Survival,A single administration of hyperthermic intraperitoneal chemotherapy at the end of cytoreductive surgery improves overall survival in women with advanced ovarian cancer.
  January 2018 ,News Alerts,Pneumothorax Events Linked to Placement of Enteral Feeding Tube,The FDA has received 79 reports (including 17 deaths) of pneumothorax events associated with feeding tube placement involving two approved enteral access systems.
  January 2018 ,Medscape Medical News,Transcranial DC Stimulation Promising in Bipolar Depression,"Transcranial direct current stimulation, added to existing therapy, was safe and effective in a small sham-controlled study of patients with bipolar depression."
  January 2018 ,Reuters Health Information,Inadequate Informed Consent Often Tied to Lawsuits Over Injectable Cosmetic Fillers,"Lawsuits related to complications from injectable cosmetic fillers are rare and most stem from inadequate informed consent, according to a cross-sectional analysis of adverse events and litigation."
  December 2017 ,Medscape Medical News,Three in 10 Doses of Metformin Not Taken by Patients With T2D,"Patients with type 2 diabetes (T2D) are less likely to take the most commonly prescribed diabetes drug, metformin, than other, newer medications, say UK researchers, who suggest adverse events may be to blame."
  December 2017 ,News Alerts,EMA Updates Contraception Advice Around Mycophenolate,"When a male patient has taken mycophenolate, either he or his female partner should use reliable contraception; it is no longer required that they both use contraception, the EMA now advises. "
  December 2017 ,Kaiser Health News,Older Americans Taking Too Many Unneeded Drugs,"Researchers estimate that 25 percent of people ages 65 to 69 take at least five prescription drugs to treat chronic conditions. But some doctors are trying to teach others about “deprescribing” or systematically discontinuing medicines that are inappropriate, duplicative or unnecessary."
  December 2017 ,Medscape Medical News,SGLT2 Inhibitors as First-line Therapy for Diabetes With CVD?,"An expert argues case for SGLT2 inhibitors as first-line therapy for patients with type 2 diabetes and CVD, but is he fighting a losing battle? As even he concedes cost is currently a major barrier. "
  December 2017 ,Medscape Medical News,First Data on Older Breast Cancer Pts on CDK4/6 Inhibitors,"Giving CDK4/6 inhibitors to breast cancer patients aged ≥70 years yields a similar progression-free survival to that seen in younger women, although the toxicity is more severe, say FDA researchers."
  December 2017 ,Medscape Medical News,"Long-term Use of Daclizumab Safe, With Caveats","Although the open-label extension study of 1500 patients with MS showed relatively positive safety results for daclizumab, investigators urge caution for those with elevated liver enzymes."
  December 2017 ,Medscape Reader Polls,Do TV Drug Ads Say Too Much About Risks?,The FDA thinks that less may be more when it comes to drug ads on TV and radio.
  December 2017 ,News Alerts,EU Regulators to Review Fibroid Drug for Possible Liver Risk,"Reports of liver damage and transplants have surfaced regarding ulipristal acetate (Esmya), now before the FDA for approval to treat uterine fibroids."
  November 2017 ,News Alerts,Flavocoxid for OA Tied to Life-Threatening Health Problems,"The FDA says several adverse events, including drug-induced liver injury and hypersensitivity pneumonitis, have been linked to flavocoxid, a medical food product marketed for osteoarthritis (OA). "
  November 2017 ,Medscape Medical News,Hormonal Contraceptives Tied to Suicide,"The researchers call for greater awareness of the possibility that hormonal contraceptives can affect mood, particularly in adolescent girls."
  November 2017 ,News Alerts,Baxter Recalls Amiodarone (Nexterone) Due to Particulate Matter,"The company identified particulate matter consistent with polyethylene, the primary constituent of the film and ports used to manufacture the bag in which Nexterone is packaged in one lot of the product. "
  November 2017 ,News Alerts,Gout Drug Febuxostat (Uloric) Subject of FDA Safety Alert,"Preliminary data from a safety study show an increased risk for heart-related deaths with febuxostat compared with allopurinol in patients with gout, the FDA said. "
  November 2017 ,Medscape Medical News,Threefold Increased Stroke Risk Tied to Certain Antipsychotics,"Second-generation antipsychotics increase risk for cardiovascular events, especially in the elderly. But are there differences in risk between these agents?"
  November 2017 ,Medscape Medical News,"JAK-1 Inhibitor Effective for RA, but Safety Signal Troubles","The oral JAK-1 inhibitor upadacitinib is showing a strong response in active rheumatoid arthritis that has responded inadequately to biologics; however, concern lingers about venous thrombotic events."
  November 2017 ,Medscape Medical News,'Unrelenting': 20-Year Recurrence Risks in Breast Cancer,Clinicians have new long-term data to use in discussions with patients with estrogen receptor-positive breast cancer who have been treated with 5 years of endocrine therapy.
  March 2018 ,Medscape Medical News,Breast Cancer Chemo Responders May Avoid Lymph Node Surgery,"Women with aggressive forms of breast cancer may be able to avoid lymph node surgery and its adverse effects if they respond well to chemotherapy, the results of two studies suggest."
  March 2018 ,Kaiser Health News,Participants in Rogue Herpes Vaccine Research Take Legal Action,"Three participants in unauthorized herpes vaccine research file a lawsuit against scientist’s company, alleging adverse side effects."
  March 2018 ,Medscape Medical News,Aggressive Approach to High-Grade Prostate Cancer May Be Best,High-dose radiotherapy plus androgen-deprivation treatment (ADT) delivered superior outcomes compared with standard external-beam radiation and ADT or radical prostatectomy alone.
  February 2018 ,International Approvals,"EU Says Yes to Mylotarg for AML, No to Adjuvant Sunitinib   ","Gemtuzumab ozogamicin (Mylotarg) has been recommended for approval in Europe for use in acute myeloid leukemia, but adjuvant sunitinib after kidney cancer surgery was turned down. "
  February 2018 ,International Approvals,Europe Says No to Neratinib for Breast Cancer,"The European committee recommended against approval of neratinib (Nerlynx) for breast cancer, even though the drug has been approved in the United States."
  February 2018 ,News Alerts,FDA Alert: Clarithromycin Risky in Patients With Heart Disease,The agency adds a new warning about the increased risk for death in patients with heart disease prescribed the antibiotic clarithromycin and recommends considering an alternative when possible. 
  February 2018 ,Medscape Medical News,"Benzodiazepine Harms Overlooked, Especially in Older Adults","International survey shows modest reductions among people aged 65 years or older, but rates of use in this population are still too high, authors say."
  February 2018 ,Medscape Medical News,"SGLT2 Inhibitor-Linked Diabetic Ketoacidosis Is Rare, but Severe ",A series of Australian cases of DKA linked to SGLT2 inhibitors confirms the side effect is rare but severe. Most cases had identifiable precipitators. 
  February 2018 ,Medscape Medical News,Exercise Benefits Cancer Patients Even 4 Years Later,A long-term follow-up showed that an exercise program conducted during active treatment continues to confer benefits even 4 years later.
  February 2018 ,Medscape Medical News,ID Docs Best Poised to Lead Antimicrobial Stewardship Programs,"The eclectic expertise of infectious disease specialists uniquely qualifies them to lead antimicrobial stewardship programs, according to a joint statement from several medical societies."
  February 2018 ,Medscape Medical News,New Guidelines for Treating Checkpoint Inhibitor Toxicities,ASCO and the NCCN have issued joint guidelines for treating toxicities associated with checkpoint inhibitor treatment.
  February 2018 ,Reuters Health Information,People on Liver Transplant Waitlist May Be No Worse Off if They Have Used Marijuana,"Candidates on the liver transplant (LT) waitlist who have used marijuana have no worse outcomes than their counterparts on the list who have not used it, a single-center study suggests."
  February 2018 ,News Alerts,PRAC Seeks New Pregnancy Prevention Measures For Retinoids,The EMA committee calls for updating pregnancy prevention measures and including a warning with retinoid products on the possible risk for neuropsychiatric disorders.
  February 2018 ,News Alerts,PRAC Recommends Regular Liver Testing for Women Taking Esmya,"The European Medicines Agency's Pharmacovigilance Risk Assessment Committee recommended liver monitoring at least monthly for women taking ulipristal acetate (Esmya, Gedeon Richter) for uterine fibroids."
  February 2018 ,News Alerts,PRAC Wants Flupirtine Off the Market in Europe,"Despite restrictions put in place in 2013, serious liver problems related to flupirtine-containing medicines continue to be reported."
  February 2018 ,Medscape Medical News,Is Ozanimod a Safer S1P Receptor Modulator? ,New safety data from the SUNBEAM and RADIANCE trials. 
  February 2018 ,Medscape Medical News,Deep Brain Stimulation May Slow Alzheimer's,Research into DBS for Alzheimer's has focused on brain regions involved in memory. A new study shows using it in frontal behavioral and cognitive neural networks may slow decline in executive function.
  January 2018 ,News Alerts,"FDA Acts to Stem Misuse, Abuse of Antidiarrheal Loperamide",The FDA moves to limit the number of loperamide doses per package amid ongoing reports of serious cardiac problems and deaths with misuse and abuse of the antidiarrhea medication.
  January 2018 ,Medscape Medical News,Cancer Immunotherapy May Be Safe for Rheumatology Patients ,"A minority of those who received immune checkpoint inhibitors and had underlying rheumatologic disease experienced flare-ups or adverse effects, a small study found."
  January 2018 ,Medscape Medical News,Genotyping May Boost Antidepressant Treatment Success,Impairments in the gene that encodes the enzyme responsible for metabolizing the antidepressant escitalopram may be responsible for treatment failure.
  May 2018 ,News Alerts,"Stop Using OTC Benzocaine Teething Products, FDA Says",The agency will also increase warnings on all benzocaine-containing over-the-counter and prescription topical anesthetics because of the rare but serious risk for methemoglobinemia.
  May 2018 ,Medscape Medical News,Canakinumab Efficacy Confirmed In Recurrent Fever Disorders ,"Canakinumab controlled flares in colchicine-resistant familial Mediterranean fever, mevalonate kinase deficiency, and tumor necrosis factor receptor-associated periodic syndrome. "
  May 2018 ,Medscape Medical News,New Data: Finasteride Safely Prevents Prostate Cancer,The thumbnail take on finasteride has been that it prevents prostate cancer but increases the risk for high-grade disease. A new study debunks the latter idea.
  May 2018 ,Medscape Medical News,"Inappropriate, Omitted Rx Common at Discharge for Older Adults","Four in five older hospitalized adults received at least one potentially inappropriate prescription at discharge, putting them at increased risk for rehospitalization and death, a study found."
  May 2018 ,Medscape Medical News,On Demand as Effective as Maintenance Therapy for Mild Asthma,"For patients with mild asthma, as-needed therapy may be just as effective and cause fewer adverse effects than daily steroid therapy."
  May 2018 ,Medscape Medical News,Deprescribing Benzodiazepines: New Primary Care Guidelines Issued,"According to new evidence-based guidelines from Canada, doctors should deprescribe benzodiazepines in all adults aged 65 and older, and in those aged 18 to 64 who have used them for more than 4 weeks."
  May 2018 ,Medscape Medical News,Hypothyroidism After TKIs for Cancer Linked to Longer Survival,"Overt hypothyroidism after tyrosine kinase inhibitor (TKI) treatment for cancer is associated with a significant survival benefit, and the adverse effect may have prognostic value, say researchers.  "
  May 2018 ,Medscape Medical News,"Neurologic Effects of Cancer Drugs May Be Severe, Fatal ","Checkpoint inhibitors have changed treatment of metastatic melanoma and other cancers. However, some immune-related neurologic adverse events that can be serious or fatal are emerging."
  April 2018 ,International Approvals,EMA Panel Recommends Once-Daily HIV-1 Treatment Biktarvy,"EMA panel recommends marketing authorization for a once-daily HIV-1 combo containing bictegravir, emtricitabine, and tenofovir."
  April 2018 ,Kaiser Health News,Drug Test Spurs Frank Talk Between Hypertension Patients and Doctors,"Roughly half of patients don’t take their high blood pressure medicine as they should, even though heart disease is the leading cause of death in America. Now, a drug test can flag whether a patient is taking the prescribed medication and is meant to spark a more truthful conversation between patient and doctor."
  April 2018 ,Medscape Medical News,Delabeling for Penicillin Allergy Found Safe in Children,"Children with low-risk penicillin allergy symptoms who tested negative for penicillin allergy tolerated penicillin without serious adverse or allergic reactions during the following year, a study found."
  April 2018 ,Medscape Medical News,Antipsychotics May Alter Thyroid Function,"Patients with severe mental disorders are more likely to be in either a hypothyroid or a hyperthyroid state than others, say Norwegian scientists, who found that antipsychotic use may affect thyroid function."
  April 2018 ,Medscape Medical News,Allopurinol: Extra Caution Urged in High-Risk Groups ,"The risk for severe cutaneous adverse reactions to allopurinol was much higher among those who were black, Asian, Native Hawaiian/Pacific Islander, women, older, or receiving higher starting doses."
  April 2018 ,Medscape Medical News,New Serious Adverse Effects With Alemtuzumab in MS ,Several new and potentially life-threatening adverse events associated with the use of this novel agent for multiple sclerosis have been reported. 
  April 2018 ,Medscape Medical News,First Trial of Three Aromatase Inhibitors,"Clinicians should use factors such as patient preference, tolerability, and cost to determine best adjuvant therapy for postmenopausal patients with early breast cancer."
  April 2018 ,Medscape Medical News,New Gene Test Reduces Skin Reactions to Carbamazepine   ,"A new gene variant test to guide treatment decisions led to reductions in the incidence of cutaneous adverse reactions to carbamazepine, a new study shows. "
  April 2018 ,Medscape Medical News,"Sepsis Alerts, Better Sleep, Handoffs Top Hospital Meeting",Hospitalists will hear about the impact of the specialty and new challenges emerging at the Society of Hospital Medicine 2018 Meeting.
  March 2018 ,Medscape Medical News,'Big Deal': NCCN Guide for Immunotherapy Adverse Events,"Some of the side effects of immunotherapies for cancer become very serious, very fast. The National Comprehensive Cancer Network (NCCN) now has an easy-to-use guideline for that."
  March 2018 ,WebMD Health News,Dermal Fillers: The Risks to Eliminating Wrinkles,"In 2016, more than 2.4 million filler procedures were done with one type alone, hyaluronic acid (Juvederm, Restylane), in the U.S. That’s a 56% increase over the last decade."
  March 2018 ,International Approvals,EU Panel Backs Dolutegravir/Rilpivirine Combo Pill for HIV,The once-daily pill can maintain viral suppression in patients on a stable antiretroviral regimen with no known or suspected resistance to a non-nucleoside reverse transcriptase inhibitor or integrase inhibitor.
  July 2018 ,Reuters Health Information,"Canada Recommends Screening Pregnant Women for Asymptomatic Bacteriuria, With Caveats","An updated guideline from the Canadian Task Force on Preventive Health Care recommends first-trimester screening of pregnant women for asymptomatic bacteriuria, affirming routine practice but acknowledging that the evidence is ""weak"" and the benefit ""small but uncertain."""
  July 2018 ,News Alerts,"FDA Orders Additional, Stronger Fluoroquinolone Warnings",Labels now must consistently reflect the antibiotics’ potential risks for mental health side effects and serious blood sugar events. The label change follows a series of warning additions over 10 years.
  July 2018 ,Reuters Health Information,Romosozumab Improves Bone Mineral Density in Men With Osteoporosis,"Romosozumab improves bone mineral density (BMD) in men with osteoporosis, but safety concerns are holding up its approval in the U.S."
  July 2018 ,Reuters Health Information,AbbVie Wins Reversal of $140 Mln Verdict in Case Over AndroGel Risks,"A U.S. judge on Thursday overturned a $140.1 million verdict against AbbVie Inc in a lawsuit by a man who claimed the company misrepresented the risks of its testosterone replacement drug AndroGel, causing him to suffer a heart attack."
  July 2018 ,Medscape Medical News,"Inhaled Heroin Tied to 'Peculiar, Often Catastrophic' Brain Damage",Heating heroin and inhaling its fumes is growing in popularity and may lead to peculiar and often catastrophic brain complications.
  July 2018 ,Reuters Health Information,Diabetes Can Follow Immune Checkpoint Inhibitor Treatment,"Life-threatening, immune-mediated type 1 diabetes can develop within weeks of commencing immune checkpoint inhibitor treatment, researchers from Australia report."
  July 2018 ,Reuters Health Information,Live and Inactivated Flu Vaccines Have Similar Efficacy in Children,"Live attenuated influenza vaccine (LAIV) and inactivated influenza vaccine (IIV) have similar efficacy in children, according to results from a Canadian Immunization Research Network (CIRN) study."
  July 2018 ,ProPublica,FDA Repays Industry by Rushing Risky Drugs to Market,"As pharma companies underwrite three-fourths of the FDA’s budget for scientific reviews, the agency is increasingly fast-tracking expensive drugs with significant side effects and unproven health benefits."
  June 2018 ,International Approvals,EMA Panel Backs Combo Drug for Hyperuricemia in Gout Patients,Duzallo contains two medicines in one pill to address both the underelimination and overproduction of uric acid. The FDA approved the drug in August 2017.
  June 2018 ,Medscape Medical News,"Penicillin Allergy Linked to MRSA, C difficile Infections","Patients with documented penicillin allergy have a greater risk of developing new methicillin-resistant Staphylococcus aureus and Clostridium difficile infections, a study has found."
  June 2018 ,Medscape Medical News,Public Citizen Calls on FDA to Pull Gout Drug Due to CV Risk ,"The nonprofit advocacy group says there is 'overwhelming evidence that the serious cardiovascular harms of febuxostat outweigh any purported clinical benefit,' citing CARES postmarket data."
  June 2018 ,Medscape Medical News,50% of Patients With PD on DAs Develop Impulse Disorders ,"Almost half of patients with Parkinson's disease who take dopamine agonists develop impulse control disorders at 5 years, a large longitudinal study shows. "
  June 2018 ,Medscape Medical News,Rx With Depression as Potential Adverse Effect Widely Used,New data suggest prescribing doctors should warn patients of this potential adverse effect and possibly assess users for mood disturbances.
  June 2018 ,Medscape Medical News,Low-Dose Antipsychotic Effective in Late-Onset Psychosis,Treatment of late-onset schizophrenia-like psychosis has been insufficiently researched. This study suggests a role for antipsychotics in reducing psychosis symptoms in this condition.
  June 2018 ,Medscape Medical News,Aspirin Plus PPI Prevents Esophageal Cancer,"Barrett's esophagus doesn't commonly progress to cancer, but there is a risk; chemoprevention with aspirin plus proton pump inhibitor (PPI) works, but also carries a risk."
  May 2018 ,News Alerts,Taytulla Birth Control Pills Recalled Due to Packaging Error,Allergan has recalled a single lot of Taytulla oral contraceptive sample packs provided to US doctors because of a packaging error that placed placebo capsules out of order. 
  May 2018 ,Medscape Medical News,Oxytocin Not Best for Postpartum Hemorrhage Prevention,"Future researchers should place more emphasis on concerns expressed by patients and families, the authors say. "
  May 2018 ,Medscape Medical News,No Reliable Predictors for Ipilimumab-Induced Hypophysitis ,Study results highlight the need for endocrine monitoring of all patients receiving checkpoint inhibitor immunotherapy. 
  May 2018 ,WebMD Health News,Vitamin Cocktail for Sepsis Getting Wider Test,"A simple vitamin cocktail to treat sepsis has shaken up the medical world, raising hopes of a more effective treatment for one of history's great killers. But will it stand up to tougher tests?"
  May 2018 ,News Alerts,"Severe Bleeding Tied to Synthetic Cannabinoids, CDC Warns","More than 200 people in nine states have developed serious, unexplained bleeding linked to synthetic cannabinoids thought to be laced with rat poison."
  July 2018 ,Reuters Health Information,Fertility Often Preserved in Female Childhood-Cancer Survivors,"Most female childhood-cancer survivors (CCSs) show normal hormonal and ultrasound markers of ovarian reserve, according to Dutch researchers."
  July 2018 ,Medscape Medical News,Unsafe Ocular Stem Cell Treatments Prevalent,"Experimental stem cell therapies for eye conditions have resulted in serious adverse events, including blinding complications, and should be avoided, investigators caution."
  July 2018 ,Medscape Medical News,FDA Panel Votes Against Recommending Mepolizumab for COPD,An FDA panel recommended against mepolizumab as add-on treatment to inhaled corticosteroid-based maintenance treatment in patients with COPD guided by blood eosinophil counts.
  July 2018 ,Reuters Health Information,Congo Declares Ebola Flare-Up Over After Rapid Response,Democratic Republic of Congo on Tuesday declared an end to an Ebola outbreak believed to have killed 33 people after what experts hailed as a swift response to the flare-up in one of the world's most difficult environments.
  July 2018 ,Reuters Health Information,Chinese Vaccine Firm Hit With Probes as Beijing Seeks to Tamp Down Outrage,"Changsheng Bio-technology Co Ltd, the Chinese vaccine maker accused of falsifying data, plunged deeper into crisis on Tuesday with police detaining its chairwoman and the country's top graft watchdog launching investigations into the firm."
  July 2018 ,Medscape Medical News,Trial Halted After 11 Infants Die in the Netherlands,Researchers were testing whether sildenafil could improve growth among fetuses with fetal growth restriction by increasing blood flow to the placenta; all related trials have been halted.
  July 2018 ,Medscape Medical News,Women Tackle Tough Choice After Dolutegravir Birth Defects,"The antiretroviral taken at the time of conception has been linked to neural tube defects in babies, but a blanket ban of the drug for all women of childbearing age strikes some as discriminatory."
  July 2018 ,Medscape Medical News,Spikes in Aflibercept Inflammations Worry Specialists,"A recent increase in inflammations associated with aflibercept injections is puzzling investigators, who report that some patients lost at least two lines of vision."
  July 2018 ,Medscape Reader Polls,Do You Recommend Probiotics and Prebiotics to Your Patients?,"Although many Americans use products that contain live microorganisms, there are few safety data about them."
  July 2018 ,Medscape Medical News,Synthetic Cannabinoid Cuts Agitation in Alzheimer's Disease,Nabilone taken daily significantly reduced agitation and improved overall behavior in patients with moderate to severe Alzheimer's disease.
  July 2018 ,Medscape Medical News,"Prince Harry, Elton John Launch Global Coalition to Halt HIV",The Duke of Sussex and Sir Elton John shared the stage Tuesday in Amsterdam to launch a billion dollar global partnership designed to expand the diagnosis and treatment of HIV infection.
  July 2018 ,News Alerts,Bayer to Halt US Sales of Essure Permanent Contraceptive,"Bayer will voluntarily halt sales of its controversial Essure permanent birth control implant in the United States at the end of this year, citing business reasons."
  July 2018 ,Reuters Health Information,Mersana's Cancer Drug Trial Put on Hold by FDA; Shares Halted,Mersana Therapeutics said on Thursday an early stage trial testing its lead cancer drug has been put on partial hold by the U.S. Food and Drug Administration after a patient's death was possibly linked to the treatment.
  July 2018 ,Reuters Health Information,L-Glutamine Benefit Patients With Sickle Cell Disease,"For people with sickle cell disease, oral twice-daily L-glutamine reduces hospitalization and trims the number of sickle cell crises compared with placebo, whether or not they are also receiving hydroxyurea, according to details of the key test that resulted in U.S. approval of the treatment just over a year ago."
  July 2018 ,Reuters Health Information,Adalimumab May Help Maintain Remission in Non-Radiographic Axial Spondyloarthritis,"In patients with active non-radiographic axial spondyloarthritis (nr-axSpA) who achieved remission while taking adalimumab, researchers saw fewer flares among those who continued taking the drug than among those who stopped taking it."
  July 2018 ,Medscape Medical News,Delayed Adverse Skin Effects After PD-1-Inhibitor Therapy,"Eczema, psoriasis, and lupuslike reactions can occur even months after starting or stopping these drugs, so patients need to be monitored on an ongoing basis."
  July 2018 ,Medscape Medical News,"Benefits, Risks of Dolutegravir Center Stage at AIDS 2018","Potentially game-changing data on HIV treatment will be presented at the International AIDS Conference, but policies that make treatment and prevention difficult will also be discussed."
  July 2018 ,Reuters Health Information,Fixed-Dose Bictegravir-Emtricitabine-Tenofovir Maintains Virologic Suppression in HIV,"Fixed-dose bictegravir-emtricitabine-tenofovir (Biktarvy) maintains virologic suppression in adults with HIV-1 who are switched from dolutegravir-abacavir-lamivudine or from boosted protease inhibitor-based regimens, according to results from two noninferiority trials."
  July 2018 ,Reuters Health Information,Cutaneous Basaloid Squamous Cell CA Regressed After HPV Vaccine Treatments,"Combined systemic and intratumoral human papillomavirus (HPV) vaccine administration resulted in complete regression of multiple cutaneous basaloid squamous cell carcinomas, according to a case report."
  July 2018 ,Medscape Medical News,Rheumatologists Cautioned to Avoid Overtreatment ,"Six common approaches to treating inflammatory rheumatic diseases might lead to overdiagnosis and overtreatment, an expert warns. Another expert says overdiagnosis is less common, however."
  August 2018 ,International Approvals,First CAR T Cells Approved in Europe,"The European Commission has approved the first CAR T-cell product, tisagenlecleucel, for the treatment of certain leukemias and lymphomas."
  August 2018 ,Medscape Medical News,"AAP: Counsel Pregnant, Lactating Women Against Marijuana Use ","In a clinical report, the AAP says an emerging body of evidence supports warning new and prospective moms about the risks marijuana use poses to pregnancy and neonatal outcomes."
  August 2018 ,Medscape Medical News,Novel Agent Dramatically Cuts Oral Mucositis After Radiation, A first-in-class synthetic superoxide dismutase dramatically reduced the duration of oral mucositis in patients with head and neck cancer  receiving radiation therapy.
  August 2018 ,Reuters Health Information,Toxin At Heart Of Drug Recall Shows Holes in Medical Safety Net,A toxin inadvertently produced in the manufacture of the widely prescribed medicine valsartan but not spotted for years raises questions about regulators' ability to detect risks in a sprawling global drug supply chain increasingly reliant on factories in China.
  August 2018 ,Medscape Medical News,"Antibiotic-Related AEs Tied to 70,000 ED Visits by Kids","Children 2 years and younger accounted for approximately 40% of the visits, and amoxicillin was the most commonly implicated antibiotic among children aged 9 years and younger."
  August 2018 ,Medscape Medical News,Dual Immunotherapy a Winner for Melanoma Brain Mets,"A combination of two checkpoint inhibitors (nivolumab and ipilimumab) achieved 'clinically meaningful' efficacy in patients with asymptomatic, untreated melanoma metastases to the brain."
  August 2018 ,Reuters Health Information,Risankizumab Effective in Moderate-to-Severe Plaque Psoriasis,"Risankizumab, a monoclonal antibody that binds to the p19 subunit of interleukin-23, is effective for treating moderate-to-severe plaque psoriasis, according to results from two phase 3 trials."
  August 2018 ,Reuters Health Information,"The Best Therapy for Cryptococcal Meningitis, According to Cochrane",Interim results of a large phase III trial showed that patients treated with a cetuximab regimen has worse survival than those treated with cisplatin plus radiation therapy.
  August 2018 ,Medscape Medical News,No Change in Standard of Care for HPV+ Oropharyngeal Cancer,Peer comparison letters sent to high-volume quetiapine prescribers led to a significant reduction in the number of prescriptions written for elderly patients.
  August 2018 ,Medscape Medical News,Peer Pressure Tactic Successfully Curbs Overprescribing,"The European Medicines Agency (EMA) said on Friday that a second Chinese contract manufacturer, Zhejiang Tianyu, had produced a common blood pressure and heart drug with an impurity that could cause cancer."
  August 2018 ,Reuters Health Information,EU Says Second China Company Made Tainted Heart Drug,"Prenatal tetanus, diphtheria, and acellular pertussis vaccination did not increase the risk of having a child with autism, according to a study. "
  August 2018 ,Medscape Medical News,"Prenatal Tdap Vaccine Not Linked to Autism, Study Finds","A wave of medical research is providing fresh evidence that marijuana may help dogs and cats cope with arthritis, epilepsy, anxiety and other maladies without the side effects of traditional drugs, but veterinarians are afraid to prescribe it for fear of running afoul of federal laws."
  August 2018 ,Reuters Health Information,Pot for Pets: U.S. Federal Law Puts Vets Into a Quandary,"Certain oral contraceptives may increase the risk of drug-induced Torsade de Pointes in women with preexisting risk factors, a new study suggests."
  August 2018 ,Reuters Health Information,Antiandrogenic Birth Control Pills Tied to Higher Risk of Drug-Induced Long QT Syndrome,The FDA has granted approval for mogamulizumab-kpkc for adult patients with relapsed or refractory mycosis fungoides or Sézary syndrome.
  August 2018 ,FDA Approvals,FDA Approves New Drug for Cutaneous T-Cell Lymphomas,"Small increased risk of blistering skin disease seen with some DPP-4 inhibitors, such as vildagliptin and linagliptin, but not others, such as sitagliptin. "
  August 2018 ,Medscape Medical News,Type 2 Diabetes Drugs Linked to Bullous Pemphigoid  ,"Pushing LDL cholesterol below current targets further reduces risk for major cardiovascular events without serious adverse effects, a new meta-analysis finds. "
  August 2018 ,Medscape Medical News,Additional Benefit From Lowering Already Low LDL ,"In a large population-based study in an Australian population, statin exposure was associated with idiopathic inflammatory myositis."
  July 2018 ,Reuters Health Information,RedHill BioPharma Has Positive Results From Crohn's Disease Trial,"The recombinant zoster vaccine Shingrix prevents shingles, and if people do contract the virus, it reduces the severity of illness, two company-funded studies suggest."
  September 2018 ,Medscape Medical News,California Sues AbbVie Over Alleged Kickback Scheme for Humira,"The complaint was prompted by a 'whistleblower' who said AbbVie allegedly hired nurses 'nationwide' to represent themselves as patient advocates when they were really company ambassadors 'hired to...keep patients on a dangerous drug at any cost,' according to the state's insurance commissioner."
  September 2018 ,Medscape Medical News,New Guidelines: Antimicrobial Prophylaxis for Cancer Patients,ASCO and IDSA have jointly issued updated guidelines for antimicrobial prophylaxis for adult patients with immunosuppression associated with cancer and its treatment.
  September 2018 ,Medscape Medical News,"ADHD Boosts Risk of Early-Onset Parkinson's, Other Diseases","Patients with attention-deficit/hyperactivity disorder (ADHD) may have an increased risk of developing Parkinson's and related diseases, particularly when treated with stimulants, preliminary data suggest."
  September 2018 ,Medscape Medical News,"Fatal Toxicity With Immunotherapy: Rare, but Increasing",A large meta-analysis reveals that reports of fatal toxic events with immune checkpoint inhibitors are still rare but are increasing as the use of these drug increases.
  September 2018 ,Reuters Health Information,White-Noise Therapy for Tinnitus May Have Adverse Brain Effects,Maryland on Thursday charged Insys Therapeutics Inc with deceptively marketing a powerful opioid pain killer so that it was prescribed inappropriately beyond its intended use with cancer patients.
  September 2018 ,Reuters Health Information,Antidepressants Lack Effectiveness for Depression in Dementia,"Severe disease at baseline may be one of the factors associated with the development of conjunctivitis following treatment of atopic dermatitis with dupilumab, according to a small retrospective study."
  September 2018 ,Reuters Health Information,Maryland Charges Insys With Engaging in Deceptive Opioid Scheme,"Clinicians should consider nalbuphine for patients with opioid-induced urine retention who do not respond to alpha-1 blockers or who want to stop bladder catheterization, the authors of a case report suggest."
  September 2018 ,Reuters Health Information,Severe Dermatitis Tied to Dupilumab-Associated Conjunctivitis,"Although sunitinib improves disease-free survival in high-risk resected renal cancer and adverse events are manageable, many patients discontinue therapy, and its role is a matter of debate, say experts."
  September 2018 ,Reuters Health Information,Nalbuphine May Be Option for Opioid-Induced Urine Retention,"About one in eight essential medicines in low- and middle-income countries may be fake or contain dangerous mixes of ingredients that put patients' lives at risk, a research review suggests."
  September 2018 ,Medscape Medical News,'Jury Still Out' on Adjuvant Therapy in Kidney Cancer,"Cutaneous adverse reactions to hydroxychloroquine in patients with dermatomyositis appear to be associated with autoantibody phenotype, according to a new study."
  August 2018 ,Reuters Health Information,"Fake, Low Quality Drugs Come at High Cost","Climbers who take zolpidem at high altitude may put their performance and safety at risk, a new study from Europe suggests."
  August 2018 ,Reuters Health Information,Hydroxychloroquine Skin Eruptions in Dermatomyositis Tied to Autoantibodies,"More people in the U.S. are dying from self-inflicted harm, including suicide and drug overdose, than from diabetes, a new study suggests."
  August 2018 ,Reuters Health Information,Radiotherapy for Some Brain Tumors May Hamper New Memories in Kids,"Nearly one in five American children uses at least one prescription medication, and roughly one in 13 kids takes more than one prescription drug, according to a new study."
  August 2018 ,Reuters Health Information,Taking Zolpidem at High Altitude May Be Unsafe,"Antibiotics are effective in children with wet cough that lasts longer than four weeks, a new Cochrane review suggests."
  August 2018 ,Reuters Health Information,U.S. Deaths From Self-Injury Surpass Those From Diabetes,Early results from a trial of JAK inhibitors for hair loss will be unveiled at the upcoming dermatology meeting. Specialists will also delve into the adverse skin effects of immunotherapy.
  August 2018 ,Reuters Health Information,US Children at Risk for Severe Drug Interactions,"With more and more states legalizing marijuana, whether for medical use, recreational use, or both, increasing numbers of Americans are using cannabis. A new survey finds that one in seven had used marijuana in 2017, with smoking being the most common manner of consumption."
  August 2018 ,Reuters Health Information,Antibiotics Effective in Children With Chronic Wet Cough,"Post-stroke intrathecal baclofen (ITB) is associated with less spasticity-related pain and improved quality of life on some measures compared to conventional management with oral antispastic drugs, researchers say."
  October 2018 ,Reuters Health Information,"Olanzapine Effective for Chemo-Induced Nausea, Vomiting","Oral olanzapine likely helps reduce nausea and vomiting in patients undergoing chemotherapy, but the optimal dose remains unclear, according to a new Cochrane review."
  October 2018 ,Reuters Health Information,More Evidence TNF Inhibitors Raise Risk of Peripheral Neuropathy,A large epidemiological study provides more evidence of a link between tumor necrosis factor inhibitors (TNFi) and peripheral neuropathy (PN).
  October 2018 ,Reuters Health Information,"No Significant Safety Concerns With Bivalent HPV Vaccine, Study Finds","Most older women who get chemotherapy for breast cancer do not experience problems with cognition in the first two years after diagnosis and treatment, a new study finds."
  October 2018 ,Reuters Health Information,Most Older Breast Cancer Patients Do Not Suffer Mental Decline After Chemo,The World Health Organization (WHO) said on Monday that there was minimal risk of children contracting the polio virus in India from a tainted batch of vaccines.
  October 2018 ,Reuters Health Information,WHO Plays Down Risk to Indian Children From Tainted Polio Vaccine,"Most patients with chronic diabetic macular edema (DME) who received a fluocinolone acetonide intravitreal implant did not require additional therapy to lower their intraocular pressure (IOP), according to a registry safety study of the implant (Iluvien, Alimera Sciences)."
  October 2018 ,Reuters Health Information,Fluocinolone Acetonide Implant Effective for Refractory Diabetic Macular Edema,Persistent red-tinted vision and cone photoreceptor damage were reported in a patient who had taken a large dose of the erectile dysfunction drug sildenafil. 
  October 2018 ,Medscape Medical News,High Dose of Sildenafil Tied to Long-term Retinal Damage,"Prenatal exposure to anti-tumor necrosis factor (TNF)-alpha therapy does not appear to affect immune system function, growth or development in young children, according to a new study."
  September 2018 ,Reuters Health Information,No Ill Effects With Prenatal Anti-TNF-Alpha Exposure in Young Kids,"Antiangiogenic agent could slow lesion growth in von Hippel-Lindau disease, sparing patients multiple surgical resections and deteriorating quality of life."
  October 2018 ,Medscape Medical News,Pazopanib Shows Promise in Rare Cancer Syndrome,"Pediatric inpatients labeled as allergic to antibiotics have worse clinical outcomes than hospitalized children without this label, new research from Australia suggests."
  September 2018 ,Reuters Health Information,Labeling Hospitalized Kids as Antibiotic-Allergic Tied to Worse Outcomes,"An experimental GlaxoSmithKline vaccine could prevent tuberculosis developing in half of those who receive it, making it potentially the first new shot against the global killer in a century, researchers said on Tuesday."
  September 2018 ,Reuters Health Information,"GSK Vaccine Success a Milestone in TB, but Room for Improvement","About one in five older patients with advanced cancer report financial difficulties, which in turn, take a toll on their mental well-being"
  September 2018 ,Medscape Medical News,Financial Toxicity Prevalent in Older Cancer Patients,A two-prong approach was able to reduce opioid use by 46% in post-op surgical patients without increasing pain or anxiety.
  September 2018 ,Medscape Medical News,New Strategy Almost Halves Opioid Use in Surgical Cancer Patients,"Five antibiotics in the pipeline for some of the most resistant bugs, one of which is a phage therapy, will be in the spotlight at the upcoming IDWeek meeting."
  September 2018 ,Medscape Medical News,"New Antibiotics, Emerging Disease Threats Ahead at IDWeek",New longer-term data provide more evidence that the investigational drug pitolisant reduces excessive daytime sleepiness (EDS) and cataplexy in patients with narcolepsy.
  September 2018 ,Reuters Health Information,Pitolisant Continues to Show Promise for Narcolepsy,"A capsule containing an experimental drug that inhibits the tyrosine kinase 2 (TYK2) signaling pathway dramatically reduced the size and severity of plaque psoriasis lesions, in a double-blind phase-2 study funded and conducted in part by the manufacturer, Bristol-Myers Squibb."
  September 2018 ,Reuters Health Information,TYK2 Inhibitor Produces Significant Improvement in Phase 2 Psoriasis Trial,"On discharge from the hospital, individuals with advanced lung cancer may be prescribed preventive drugs for conditions such as diabetes and heart disease, and efforts should be made to ""deprescribe"" such medications, researchers say."
  September 2018 ,Reuters Health Information,Preventive Drug Prescribing Common in Lung Cancer Patients Near End of Life,"The Indian government has banned 328 combination drugs in a blow to both domestic and foreign pharmaceutical firms, but the ban has been cheered by health activists worried about growing antibiotic resistance due to the misuse of medicines."
  September 2018 ,Reuters Health Information,India Bans 328 Combination Drugs in Setback for Pharma Companies,"A new fixed-dose combination of doravirine/lamivudine/tenofovir disoproxil fumarate (DOR/3TC/TDF) is noninferior to fixed-dose efavirenz/emtricitabine/TDF (EFV/FTC/TDF) in treatment-naive adults with HIV-1 infection, according to results from the DRIVE-AHEAD trial."
  September 2018 ,Reuters Health Information,New Single-pill Combo Effective Against HIV-1,"Intravenous (IV) oxytocin is more effective than intramuscular (IM) oxytocin for preventing severe postpartum hemorrhage (PPH) after vaginal delivery, a new randomized controlled trial shows."
  October 2018 ,Reuters Health Information,Vascular Disease Risk a Consideration in Endocrine Therapy for Breast Cancer,"Whether a female breast cancer survivor receives an aromatase inhibitor (AI) or tamoxifen should be based on the drug's effectiveness against recurrence, but her risk of venous or arterial disease should also be considered, researchers say."
  October 2018 ,Reuters Health Information,Calorie-Dense Feedings Fail to Benefit ICU Patients on Ventilators,"Increasing the calorie density of enteral nutrition by 50% offers no 90-day survival benefit for critically-ill patients undergoing mechanical ventilation, according to a new study done in 46 intensive care units in Australia and New Zealand."
  October 2018 ,News Alerts,FDA Warns Against Using Raindrop Near Vision Inlay,The FDA today issued an alert about an increased risk for corneal haze in patients with the device after 75% of patients in a postapproval study developed haze.
  October 2018 ,Medscape Medical News,ONJ With Bone-Modifying Agents in Breast Cancer Patients   ,Osteonecrosis of the jaw was reported in metastatic breast cancer patients treated with bone-modifying agents; the incidence was higher with denosumab compared with  bisphosphonates. 
  October 2018 ,Reuters Health Information,Cardiotoxicity Common With Angiogenesis Inhibitors,Tyrosine kinase inhibitors that target vascular endothelial growth factor receptor (VEGFR-TKIs) are commonly associated with cardiovascular toxicity.
  October 2018 ,Medscape Medical News,Precision RT May Prove Curative in Oligometastatic Cancer,"Precision, high-dose radiotherapy targeting isolated metastatic lesions significantly boosts overall and progression-free survival, with good quality of life for patients with oliogometastatic tumors."
  October 2018 ,Medscape Medical News,Gender Differences in Chemo Side Effects,"Although outcomes and rates overall toxicity of esophagogastric cancer chemotherapy are similar for men and women, rates of nausea, diarrhea, and hair loss are higher in women, warn UK scientists."
  October 2018 ,Medscape Medical News,Safe to Stop MS Disease-Modifying Therapy After Age 60?,"To add more evidence to the controversial debate over stopping immunomodulatory therapy for multiple sclerosis after age 60, researchers focus on quality of life, walking performance, and relapse rates."
  October 2018 ,Medscape Medical News,Prenatal Fluoride Exposure Linked to ADHD in Kids,"To think that water fluoridation is unsafe has long been considered a fringe belief, but recent research suggests cause for concern."
  October 2018 ,Medscape Medical News,Ketamine Dosing for Depression May Not Be 'One-Size-Fits-All',A study confirms the antidepressant effects of intravenous ketamine at the standard 0.5 mg/kg dose and hints that a lower dose might also have some benefit with fewer side effects.
  October 2018 ,Medscape Medical News,"Given Access, Cancer Patients Read Their Doc's Notes","When given easy access to their medical records, cancer patients positively report trust in their physicians and better understanding of treatments, diagnosis, and side effects."
  October 2018 ,Reuters Health Information,Two Drugs for Uterine Leiomyomas Show Promise,"Ulipristal acetate, a selective progesterone receptor modulator, and elagolix, an oral gonadotropin-releasing hormone receptor antagonist, are effective for the treatment of uterine leiomyomas, according to two industry-sponsored randomized controlled trials."
  October 2018 ,Reuters Health Information,"Public Seems to Know Value of Clinical Trials, but Not How They Work","Patients, their families and friends may see clinical trial research as important, yet they don't know much about the research process and see trial participation as burdensome, a new study suggests."
  October 2018 ,Reuters Health Information,Antibiotic Outcomes Comparable in Early Cutaneous Lyme Borreliosis,"Neither the treatment modality nor the antibiotic employed appears to have a notable impact on efficacy or adverse effects in patients with early cutaneous Lyme borreliosis, according to German researchers."
  October 2018 ,Medscape Medical News,"CAM Popular, but Cancer Patients Unaware of Risks","Two studies involving sarcoma patients show that complementary and alternative medicine (CAM) treatments are popular, and most patients seem to be unconcerned about risks, such as interactions."
  October 2018 ,Medscape Medical News,"Popular 'Club Drug' Tied to Brain, Cognitive Changes","Gamma-hydroxybutyrate, which is widely used as a 'party drug,' causes functional brain changes, especially after drug-related comas, Dutch researchers have shown for the first time."
  October 2018 ,Reuters Health Information,FDA Staff Raises Safety Issues Over Trevena Opioid Injection,"Trevena Inc's opioid injection to treat acute pain could be abused and potentially lead to overdose, staff reviewers of the U.S. Food and Drug Administration said on Tuesday, sending the drugmaker's shares down 66 percent."
  October 2018 ,Medscape Medical News,LAMAs Are Safe Irrespective of Cardiovascular Risk in COPD,"Long-acting antimuscarinic antagonists are safe for patients with chronic obstructive pulmonary disease and will not increase the risk for a cardiovascular event, new data show."
  October 2018 ,Reuters Health Information,J&J's Stelara Succeeds in Ulcerative Colitis Study,Johnson & Johnson said on Tuesday its blockbuster drug Stelara (ustekinumab) was found to be effective in treating ulcerative colitis (UC) in a late-stage trial.
  October 2018 ,Reuters Health Information,Genetically Modified Pertussis Vaccine Produces Lasting Response,"Monovalent and combined acellular pertussis vaccines made with genetically inactivated toxin produce a stronger and more sustained antibody response than those containing chemically inactivated toxin, a new phase 2/3 trial shows."
  November 2018 ,Medscape Medical News,Trial Confirms Low-Dose Radiation for Low-Risk Thyroid Cancer,The safety and efficacy of low-dose radioactive iodine in patients with low-risk thyroid cancer has been confirmed by UK researchers in the longest-running trial of radiation treatment in this setting.
  November 2018 ,Medscape Medical News,Identifying Low-Risk Medulloblastoma to De-escalate Therapy ,"Children with brain tumors that have a low-risk chromosomal signature could eventually be given lower-intensity treatment, suggests a new analysis."
  November 2018 ,Reuters Health Information,More Pregnant Women in US Smoking Pot,"Even as alcohol and tobacco use continue to decline among pregnant women in the U.S., a new study offers fresh evidence that more American mothers are using cannabis during pregnancy."
  November 2018 ,Medscape Medical News,Familiarity With Adverse Effects of Checkpoint Inhibitors Urged,"As checkpoint inhibitors are increasingly used, it is important that physicians other than oncologists become familiar with the presentation and management of common adverse events."
  November 2018 ,Medscape Medical News,Jury Still Out on Neural Tube Defects From Dolutegravir,"After an increased risk for neural tube defects emerged in women taking dolutegravir at conception in a Botswanan cohort, researchers around the world began reviewing their data for any such signal."
  November 2018 ,Medscape Medical News,Rose Geranium Oil Eases Chemo-Induced Nasal Pain,"Rose geranium in sesame oil nasal spray improved patient-reported nasal symptoms associated with chemotherapy in this small, single-center study."
  November 2018 ,Reuters Health Information,Polymorphisms Tied to Bexarotene Side Effects in Cutaneous Lymphoma,"Screening for APOA5 and APOC3 polymorphisms in patients with cutaneous T-cell lymphoma might help identify those less likely to experience hypertriglyceridemia associated with bexarotene treatment, according to Spanish researchers."
  November 2018 ,Reuters Health Information,Prostate Cancer Surgery and Radiation Tied to Antidepressant Use,"Men with prostate cancer who undergo surgery or radiation therapyare also more likely start taking antidepressants than their counterparts who don't get aggressive treatment, research suggests."
  November 2018 ,Medscape Medical News,Repeated CBD Doses Required for Effective Pain Relief,"Repeated administration of cannabidiol (CBD) is needed to treat neuropathic pain and related anxiety, according to new research that shows how the drug acts on specific brain receptors."
  October 2018 ,Reuters Health Information,Antibiotic Use Before Age 2 Tied to Slight Weight Gain by Age 5,"In children under age two, antibiotic use is linked with slightly higher body weight at age five, researchers say."
  October 2018 ,Reuters Health Information,Routine Monitoring Unneeded for Most Patients on Oral Dermatophyte Therapy,"Healthy adults and children treated with oral terbinafine or griseofulvin for dermatophyte infections don't need to be monitored for liver or blood abnormalities, researchers say."
  October 2018 ,Reuters Health Information,"Study Supports RAS Blocker After AKI, With Close Clinical Monitoring","Use of a renin angiotensin system (RAS) blocker after acute kidney injury (AKI) provides protection against death but may be accompanied by higher rates of hospitalization due to renal problems, a new analysis from Canada suggests."
  October 2018 ,Reuters Health Information,UK Police Charge Pharmaceutical Company Over Hospital Baby Deaths,Police said on Wednesday they had charged pharmaceutical company ITH Pharma with a number of offenses as part of an investigation into the deaths and illnesses of seven babies at several hospitals.
  October 2018 ,Reuters Health Information,Therapeutic Clozapine Levels Best Achieved With Higher Fluvoxamine Doses,A review of cases shows that rare but serious adverse events occur early with treatment and can be manifested in diverse neurologic disorders.
  October 2018 ,Medscape Medical News,Neurologic Adverse Events With Checkpoint Inhibitors in Cancer,"Public health offices express concern over questionable medical exemptions following passage of a law limiting nonmedical exemptions in California, study authors write."
  October 2018 ,Medscape Medical News,Questionable Medical Exemptions for Vaccines Up After New Law,A new study debunks a common recommendation that patients avoid use of topical agents before daily radiation treatments because it found that these agents have a minimal effect on skin dose.
  October 2018 ,Medscape Medical News,Radiotherapy Patients Can Safely Use Lotions for Irritated Skin,"De-escalating therapy by using cetuximab with radiotherapy did not improve side effects and, more importantly, had worse survival compared with chemoradiotherapy for patients with good prognosis HPV+ throat cancers."
  October 2018 ,Medscape Medical News,No De-escalation of Therapy for HPV+ Throat Cancer,"Restless leg syndrome is strongly linked to suicidal thoughts and behavior, even in the absence of depression, new research shows."
  October 2018 ,Medscape Medical News,Restless Legs Tied to Suicide Even in the Absence of Depression,"Benzodiazepines may be associated with an increased risk of suicide in patients with chronic obstructive pulmonary disease (COPD) and comorbid posttraumatic stress disorder (PTSD), according to a retrospective study."
  November 2018 ,Medscape Medical News,Novel 'Blended Therapy' May Help Cut High-Dose Opioid Use,"Resurrecting an older analgesic and adding high-dose codeine and other drugs to curb side effects reduce opioid intake without withdrawal or increased pain, new research suggests."
  November 2018 ,Medscape Medical News,Immunotherapy Adverse Events More Common Than Initially Reported,"The rate of immunotherapy adverse events, as evidenced in real world data, is much higher than was previously reported in the pivotal clinical trials of these agents."
  November 2018 ,Reuters Health Information,Doctors Still Advise Against Marijuana for Pregnant and Breastfeeding Women,"Even though there are still a lot of unknowns about the effects of marijuana exposure in the womb and from breast milk, research to date still suggests that pregnant and nursing women avoid cannabis, U.S. doctors recommend."
  November 2018 ,Reuters Health Information,Tens of Thousands Die in Africa Each Year Due to Fake Drugs,"When Moustapha Dieng came down with stomach pains one day last month he did the sensible thing and went to a doctor in his hometown of Ouagadougou, Burkina Faso's capital."
  November 2018 ,News Alerts,"EMA Curtails Use of Fluoroquinolone, Quinolone Antibiotics",The occurrence of disabling and potentially permanent side effects associated with quinolone and fluoroquinolone antibiotics has led the European Medicines Agency (EMA) to restrict or suspend their use.
  November 2018 ,Reuters Health Information,Transdermal Nitroglycerin May Help Ease Tendon Pain,"Nitroglycerin patches help patients with common injuries to tendons, a research review suggests."
  November 2018 ,Medscape Medical News,Just One Energy Drink Reduces Endothelial Function,"A new study shows that consuming just one can of an energy drink was linked to an almost 50% reduction in arterial dilation, which could lead to problems, particularly during exercise. "
  November 2018 ,Reuters Health Information,Age Key Determinant in Fertility-Preservation Success,"Women who undergo fertility preservation (FP) are more likely to deliver a live baby if they freeze their eggs before their 36th birthday, according to new findings."
  November 2018 ,Medscape Medical News,Downplaying Drug Toxicity in Oncology Clinical Trials,Incomplete reporting that downplayed drug-related adverse events was identified in 43% of reports of cancer drug trials published by top medical journals.
  November 2018 ,Medscape Medical News,Exercise Program Prevents Decline Among Older Inpatients,"A multicomponent exercise program was associated significant benefits in cognitive and functional capacity after as few as 5 days, investigators found."
  November 2018 ,Reuters Health Information,Filgrastim Biosimilars Comparable to Reference Drug,"Nearly half of primary care patients were prescribed any of three common drug types for longer than necessary, contributing to a form of inappropriate polypharmacy termed 'legacy prescribing.'"
  November 2018 ,Medscape Medical News,Nearly Half of Patients Have Rx Longer Than Needed,"Colony-stimulating growth factors (CSF) biosimilars filgrastim-sndz and filgrastim-tbo are comparable in terms of safety and efficacy to the reference drug (Neupogen and other brand names), researchers say."
  November 2018 ,Reuters Health Information,Filgrastim Biosimilars Comparable to Reference Drug,The trial did not show a significant reduction in  major adverse cardiovascular events but does extend the heart failure benefits of SGLT2 inhibitors to the primary prevention population. 
  November 2018 ,Medscape Medical News,DECLARE-TIMI 58: Dapagliflozin Cuts Heart Failure in Diabetes ,"High doses of a purified form of the omega-3 oil, eicosapentaenoic acid, showed a large, robust reduction in events, opening an exciting new avenue for CVD prevention, researchers say.   "
  November 2018 ,Medscape Medical News,REDUCE-IT: 'A New Era' in CVD Prevention With High-Dose EPA ,The findings suggest no negative effects of pregnancy weight management efforts on the bone health of offspring.
  November 2018 ,Medscape Medical News,Prevent Excessive Weight Gain in Pregnancy for Kids' Bone Health,"Cooling the scalp may help prevent taxane-induced alopecia, whereas frozen gloves and socks may prevent nail and cutaneous side effects of the drugs, researchers say."
  November 2018 ,Reuters Health Information,Cryotherapy May Curb Taxane-Induced Dermatologic Side Effects,"Foamix Pharmaceuticals Ltd said on Wednesday its experimental foam treatment for rosacea, a common skin condition that causes acne-like bumps and redness on the face, met the main goals of two late-stage clinical trials."
  November 2018 ,Reuters Health Information,Foamix's Treatment for Common Skin Condition Meets Late-Stage Trial Goals,"The experimental drug solriamfetol appears to keep sleepy patients with narcolepsy or obstructive sleep apnea (OSA) awake and alert, according to an industry-sponsored trial."
  November 2018 ,Reuters Health Information,"Solriamfetol Effective for Excessive Sleepiness in OSA, Narcolepsy","Patients being considered for rituximab therapy should be screened for hypogammaglobulinemia before and after rituximab administration, researchers report."
  December 2018 ,Medscape Medical News,"Effect of Cardiac Rehab on Sexual Health Unclear, Poorly Studied",Observers say there is an urgent need for more consideration and study of sexual health in cardiac rehabilitation of patients with heart disease. 
  December 2018 ,Medscape Medical News,Go Low With Tamoxifen for DCIS,"In a potentially practice-changing result, use of a 5-mg daily dose of tamoxifen for patients with ductal carcinoma in situ (DCIS) prevented new and recurrent breast cancer events in comparison with placebo."
  December 2018 ,Reuters Health Information,Whole-Brain Radiation May Lead to Dry Mouth,"Parotid gland exposure during whole-brain radiation therapy (WBRT) may unnecessarily cause significant xerostomia, according to a small prospective observational study."
  December 2018 ,Medscape Medical News,Almost Half of Americans to Skip Flu Shot This Year,"Top reasons cited for not getting vaccinated include a lack of confidence in the flu vaccine, concern about side effects from the vaccine, or just thinking they will not get the flu."
  November 2018 ,Reuters Health Information,Skipping Cannabis for One Month Improves Memory in Teens,"Not using cannabis for one month could improve learning ability for adolescents and young adults who use the drug at least weekly, a U.S. study suggests."
  November 2018 ,Reuters Health Information,Dapsone Useful for Chronic Spontaneous Urticaria,"Dapsone is an effective second-line treatment for chronic spontaneous urticaria (CSU) patients in whom antihistamines and other first-line therapies have failed, researchers say."
  November 2018 ,Reuters Health Information,More Reports of Diabetes Tied to Use of Immune-Checkpoint Inhibitors,"Reports of diabetes associated with immune-checkpoint inhibitors have increased markedly in the past few years, researchers report."
  December 2018 ,Medscape Medical News,Four Cycles of CHOP Instead of Six for Favorable DLBCL ,Patients with favorable-prognosis DLBCL receiving four cycles of R-CHOP followed by two additional cycles of rituximab had outcomes similar to those in patients receiving six cycles.   
  November 2018 ,Reuters Health Information,Older Drivers Taking Multiple Medications Could Be at Higher Risk of Accidents,"Many older drivers are taking multiple medications that may increase the risk of car crashes, a new U.S. study released today suggests."
  November 2018 ,Reuters Health Information,"Teva Prices EpiPen Generic At $300, Same Price as Mylan Generic",Teva Pharmaceutical Industries Ltd said on Tuesday it launched its generic version of Mylan NV's EpiPen at the wholesale price of $300 for a pack of two auto-injectors - the same price as Mylan's generic version of the emergency allergy shot.
  November 2018 ,Medscape Medical News,Experts: Magic Mouthwash Should 'Vanish Into Thin Air',Mixed-medication mouth rinses are commonly used for oral pain and inflammation that accompany some cancer treatments. Should they be?
  November 2018 ,Reuters Health Information,Bristol-Myers Squibb Says Cancer Drug Combination Fails Late-Stage Trial,"Bristol-Myers Squibb Co said on Monday a combination of two of its cancer drugs, being tested as a maintenance therapy, did not meet the main goal of extending the lives of lung cancer patients in a late-stage trial."
  November 2018 ,Reuters Health Information,South Africa's Aspen Launches Three-in-One HIV Drug,South African drugmaker Aspen Pharmacare on Monday launched a triple-combination tablet for the treatment of HIV in the country where the virus is most prevalent.
  November 2018 ,Medscape Medical News,One in Five Cancer Tumors Grow Before Shrinking: Nivolumab,"Immunotherapy can cause tumors to grow before they decrease in size, so patience is needed for the treatment to work, new research shows."
  November 2018 ,Reuters Health Information,Cannabis Might Relieve Symptoms in Some With IBD,"Jack B Goods Outlet Store and MA Labs receive warning letters from the FDA for marketing diet supplements containing the unapproved antidepressant tianeptine for opioid addiction, pain, and anxiety. "
  November 2018 ,Reuters Health Information,EpiPens Withstand 24 Hours of Freezing,"European Union authorities on Monday stepped in to effectively ban sales of blood pressure medicine valsartan made by an India-based unit of Mylan NV after some batches were found to contain a probable cancer-causing impurity, the latest in a global crackdown."
  November 2018 ,Medscape Medical News,FDA Warns Sellers of Illegal Tianeptine Supplements ,"Allergy to marijuana can occur in adults who use it, but researchers are flagging the first report of a young child with a positive allergy test who was exposed only to secondhand smoke."
  November 2018 ,Reuters Health Information,EU Cracks Down on Valsartan Made by Mylan,A pharmacovigilance study reports four new cardiotoxicities in patients treated with immune checkpoint inhibitors. Experts say this should not deter physicians from offering these treatments to patients.
  January 2019 ,Medscape Medical News,USPSTF Reaffirms Drugs for Women at High Risk for Breast Cancer,"In new draft guidelines, the US Preventive Services Task Force (USPSTF) continues to recommend the use of chemopreventive agents for women at high risk for breast cancer."
  January 2019 ,Reuters Health Information,Drugs Derived From Pigs Could Be Risky in People With Alpha-Gal Syndrome,"People with alpha-gal syndrome may develop allergic reactions to drugs that contain ingredients derived from pigs, researchers in Europe report."
  January 2019 ,Reuters Health Information,Vaginal Ring Pessary Suitable for Extended Use in Advanced Pelvic-Organ Prolapse,"A vaginal ring pessary with support can alleviate symptoms of advanced pelvic organ prolapse (POP) for three years or longer, according to a new study."
  January 2019 ,Reuters Health Information,Diabetic Ketoacidosis May Affect Brain Development in the Young,"Even a single episode of diabetic ketoacidosis (DKA) in school-aged children may have an enduring effect on cognitive function, a study suggests."
  January 2019 ,Reuters Health Information,Intranasal Ketamine as Effective as Fentanyl at Relieving Acute Pain in Kids,"Intranasal ketamine is noninferior to intranasal fentanyl at relieving pain in children with acute extremity injuries, a new study found."
  January 2019 ,Reuters Health Information,Physicians Urge Caution Regarding Medical Uses of Marijuana and Cannabinoids,"While advocates of marijuana and cannabinoids promote its use for conditions ranging from nausea to cancer, the paucity of high-quality evidence demands caution regarding the use of these agents, according to 6 brief commentaries from physicians and other providers across the US."
  January 2019 ,Reuters Health Information,Study Finds Drops in Contraindicated-Statin Use in HIV-Infected Adults on ART,"Contraindicated statin use declined between 2007 and 2015 in HIV-infected adults treated with antiretroviral therapy (ART), while overall use remains suboptimal, researchers report."
  December 2018 ,Reuters Health Information,"Data on Safety, Effectiveness of Common Acne Drug Unreliable, Some Researchers Say","Isotretinoin, a drug for severe chronic acne, has long been linked to miscarriages, birth defects and other serious problems, but a research review suggests much of data on the drug's safety, effectiveness and side effects may be unreliable."
  December 2018 ,Medscape Medical News,"Pruritus Can Be Frequent, Severe With Cancer Immunotherapy ",Immunotherapy-related pruritus can be frequent and even severe in cancer patients receiving treatment with any of the new agents
  December 2018 ,Medscape Medical News,Weekly Full-Body Massage Improves Short-term Knee OA Pain,"Two months of weekly 1-hour Swedish massage significantly improved pain and function in patients with knee osteoarthritis, a randomized trial showed."
  December 2018 ,Reuters Health Information,Acute Kidney Injury Common During Chemotherapy,"Nearly one in 10 cancer patients treated with chemotherapy or newer targeted drugs may be hospitalized for acute kidney injury, a Canadian study suggests."
  December 2018 ,Reuters Health Information,"Children's Hospital Patients Receive Broadly Comparable Care From Pediatricians, Hospitalists","Children cared for as inpatients by hospitalists had similar lengths of stay, total costs, and readmission rates as those treated by general pediatricians, in a study conducted at a single children's hospital in the U.S."
  December 2018 ,Reuters Health Information,GLP-1 Receptor Agonists Not Linked With Diabetic Retinopathy,"Glucagon-like peptide 1 receptor agonists (GLP-1RAs) do not appear to increase patients' risk for diabetic retinopathy, according to an analysis of the U.S. Food and Drug Administration Adverse Event Reporting System database."
  December 2018 ,Medscape Medical News,Opioids for Chronic Pain Only Nominally Better Than Placebo,"Opioids offer marginal pain-control benefits over placebo for patients with chronic pain and ""should not be first-line therapy"" for pain management, investigators of a new meta-analysis say."
  December 2018 ,FDA Approvals,FDA OKs Prucalopride (Motegrity) for Chronic Idiopathic Constipation,"Prucalopride, a selective serotonin-4 (5-HT4) receptor agonist, enhances bowel motility by stimulating colonic peristalsis."
  December 2018 ,Medscape Medical News,Long-Term Efficacy for Epidiolex in Resistant Epilepsy  ,"Results of open-label extension trials show the recently approved drug Epidiolex, a purified form of CBD, is safe and effective beyond a year in patients with two rare and resistant epilepsy types."
  December 2018 ,Medscape Medical News,Steer Clear of Driving While Taking Prescribed Opioids?,"Higher-dose opioids impair driving performance to a minor degree, but patients still need to be advised of this risk so they can decide whether to steer clear of driving while taking these meds."
  December 2018 ,Reuters Health Information,Drugs That Exacerbate Restless Legs Syndrome Frequently Prescribed,"Patients with restless legs syndrome (RLS) are often prescribed drugs that exacerbate the condition, while prescriptions of drugs approved to treat it have fallen, researchers say."
  December 2018 ,Reuters Health Information,Androgen-Deprivation Therapy Linked to Increased Risk of Heart Failure,"The use of androgen-deprivation therapy (ADT) in men with prostate cancer is associated with an increased risk of heart failure, researchers from Taiwan report."
  December 2018 ,Reuters Health Information,"After a Child's Dire Diagnosis, Hope and Uncertainty at the Frontiers of Medicine","""I wish I didn't have this hand anymore,"" my 4-year-old son said as he woke one winter morning."
  February 2019 ,Reuters Health Information,Narrow Band UV-B Phototherapy May Be Helpful in Mycosis Fungoides,"Narrowband UV-B phototherapy (UVB) appears to be almost as effective as psoralen-UV-A (PUVA) phototherapy for treating early-stage mycosis fungoides, according to pooled observational data."
  February 2019 ,Reuters Health Information,China Says Tests of Possibly Tainted Medical Product Show No HIV,"China is investigating a manufacturer of medical products following reports that it sold human immunoglobulin for intravenous injection that had possibly been contaminated with HIV, though authorities said tests found no sign of the virus."
  February 2019 ,WebMD Health News,Fluoroquinolones Overprescribed Despite Dangers,"In the past year, more concerns about the drugs' side effects have led the FDA to issue new warnings about their use."
  February 2019 ,Reuters Health Information,Antenatal Betamethasone Does Not Impair Neurocognitive Function in Fetal Growth Restriction,"Repeated antenatal doses of betamethasone does not impair neurocognitive function in elementary-school-aged children born with fetal growth restriction, according to a secondary analysis from the ACTORDS clinical trial."
  February 2019 ,Reuters Health Information,In Utero Dioxin Exposure Effects May Differ by Gender,"Prenatal dioxin exposure may have gender-specific effects on cardiometabolic risk, a new study suggests."
  February 2019 ,Medscape Medical News,Stop ECT for Refractory Depression? The Great Debate,"Experts argue for, and against, electroconvulsive therapy (ECT) for severe, refractory depression in a 'head-to-head' article in the BMJ."
  January 2019 ,Reuters Health Information,Teva's Generic EpiPen Launch Stalls Months After Approval,"Many of the largest U.S. pharmacies and drug distributors do not have Teva Pharmaceutical Industries Ltd's generic version of the life-saving EpiPen allergy treatment five months after it was approved for sale in the United States, pharmacy chains and a group that tracks drug shortages told Reuters."
  January 2019 ,Reuters Health Information,Azathioprine Ups Pancreatitis Risk in Pediatric IBD,"Azathioprine is associated with a six-fold increased risk of acute pancreatitis in children with inflammatory bowel disease (IBD), new research shows."
  February 2019 ,News Alerts,Dacomitinib for EGFR+ Lung Cancer Gets EU OK,Dacomitinib has been given a positive opinion in Europe for use in the first-line treatment of EGFR+ non-small cell lung cancer.
  January 2019 ,Medscape Medical News,Early Surveillance Data Confirm Safety of Shingrix Vaccine,New research from the CDC confirms the safety of the Shingrix recombinant zoster vaccine.
  January 2019 ,Reuters Health Information,"Information, Not Urgency, Boosts Parents' Confidence in HPV Vaccine","Physician messages that provide information, not a sense of urgency, help reassure parents who are reluctant to have their children vaccinated against human papilloma virus (HPV), researchers say."
  January 2019 ,Reuters Health Information,Models Predict Adverse Event Risk With Levetiracetam,"Two prediction models can determine the risk of adverse psychiatric events in patients with incident epilepsy prescribed levetiracetam, new findings in JAMA Neurology show."
  January 2019 ,Medscape Medical News,No Effect of Levodopa on Parkinson's Progression,"Use of levodopa in early Parkinson's disease does not have any disease-modifying effect, either beneficial or detrimental, a new study suggests."
  January 2019 ,Medscape Medical News,'Impressive' Activity with BRAF/MEK Inhibitors in Biliary Cancer,Combination therapy with dabrafenib and trametinib produced promising results in patients with advanced BRAF V600E-mutated biliary cancers.
  January 2019 ,Reuters Health Information,TRPV1 Antagonist Cream Shows Promise Against Eczema in Adults,"An investigational nonsteroidal topical cream (PAC-14028, or Asivatrep) may be a safe, effective treatment for atopic dermatitis, Korean researchers suggest."
  January 2019 ,Medscape Medical News,Survival Benefit With Combo Immunotherapy in Advanced CRC,Combined durvalumab and tremelimumab improved overall survival in patients with advanced refractory colorectal cancer who were unselected for mismatch repair deficiency.
  January 2019 ,Medscape Medical News,"Deaths From Adverse Events Down Slightly, Study Shows","Deaths from adverse effects of medical treatment fell from 1990 to 2016; the risks are not evenly distributed, however, with some age groups and geographic regions more affected than others. "
  January 2019 ,Reuters Health Information,Planning Ahead is Common Among Users of Erectile-Dysfunction Meds,"Three out of four East Asian men who use erectile dysfunction (ED) medications typically planned their sexual activity, with majorities of the participants in an online survey agreeing that they plan for sex on specific days of the week or times of day, according to Taiwanese researchers."
  January 2019 ,Reuters Health Information,Misdiagnosis of Penicillin Allergy Common,"Most patients who report having a penicillin allergy are not really allergic to the antibiotic, and they may be missing out on the best treatment for their condition as a result, according to a report in JAMA January 15."
  January 2019 ,Reuters Health Information,Intoxication From Synthetic-Cannabinoid-Receptor Agonists Often Missed,"Nearly half of patients with suspected synthetic-cannabinoid-receptor agonist (SCRA) intoxication test negative for an SCRA, and many test positive for another substance, researchers report."
  March 2019 ,Reuters Health Information,Single-Patient Trials Help Find Best Medication for Hypertensive Kids,"There is no single blood pressure-lowering drug that works for most hypertensive children, but single-patient randomized crossover trials (n-of-1 trials) can be used to optimize their management, researchers report."
  March 2019 ,Reuters Health Information,"Philippines to Charge Officials of Sanofi, Gov't Over Deaths Linked to Vaccine",The Philippine Department of Justice said on Friday it has found probable cause to indict officials from French drugmaker Sanofi and former and current Philippine health officials over 10 deaths it said were linked to use of a dengue vaccine.
  March 2019 ,Reuters Health Information,Ophthalmic Timolol Causes Systemic Exposure,"Most children given topical timolol to treat hemangioma have plasma levels of the drug that would have beta-blocking effects in adults, new findings show."
  March 2019 ,Reuters Health Information,Fluorouracil Plus Calcipotriene May Help Refractory Extramammary Paget Disease,"In patients who fail other therapies for extramammary Paget disease (EMPD), palliative therapy with topical fluorouracil and calcipotriene may be an option, a small case series suggests."
  March 2019 ,Medscape Medical News,Dermatologists Can Help Ease Adverse Effects of Cancer Drugs,"Data support cooling therapies for the prevention of taxane-induced alopecia and skin and nail changes, a systematic review shows, and dermatologists are ready to help."
  March 2019 ,Medscape Medical News,Acupuncture a 'Realistic Option' vs HRT for Hot Flashes,"A small study shows that acupuncture is better than no treatment for menopausal symptoms and is a realistic option for women who cannot or do not wish to use hormone replacement therapy (HRT), say researchers."
  February 2019 ,Reuters Health Information,Vaginal Laser Treatment Tied to Complications Like Scarring,"Vaginal laser treatments may help relieve problems associated with menopause, like dryness, pain and sexual dysfunction, but the safety of this technique is not clear, suggest the authors of a small study describing complications including scarring and penetration injuries."
  February 2019 ,Reuters Health Information,NUDT15 Variants Linked to Thiopurine-Induced Myelosuppression,"Genetic variants in NUDT15, along with those previously identified in TPMT, are associated with thiopurine-induced myelosuppression (TIM) in patients with inflammatory bowel disease (IBD), according to findings from the IBD Pharmacogenetics Study Group."
  February 2019 ,Medscape Medical News,Lawmakers Seek to Increase Use of Measles Vaccine Amid Outbreaks,Members of the US House of Represenatives used a Wednesday hearing to promote use of the measles shot. They also delved into the factors that keep parents from having their children vaccinated.
  February 2019 ,Reuters Health Information,Hypofractionated Radiotherapy Appropriate for Low-Risk Prostate Cancer,"Hypofractionated radiotherapy (HRT) should be a new practice standard for men with low-risk prostate cancer, based on a secondary analysis of a phase III trial."
  February 2019 ,Medscape Medical News,"IPT for Cancer Unproven, May Do Harm","When a cancer patient asks about unproven therapies such as insulin-potentiation therapy (IPT), don't brush the question aside: this is a chance to  provide information, say clinicians. "
  February 2019 ,Reuters Health Information,Pediatric Medical Overuse Persists,"Evidence of pediatric medical overuse persists, but there are glimmers of progress, according to a new review."
  February 2019 ,Reuters Health Information,New Recombinant Vaccine Most Cost-Effective Alternative for Preventing Herpes Zoster,"The new recombinant zoster vaccine (RZV) is more cost-effective than both the zoster vaccine live (ZVL) and no vaccination for preventing herpes zoster and related complications, according to a model study."
  February 2019 ,Reuters Health Information,"Expired Drugs May Remain Effective, Safe to Use in a Pinch","Even medicines that are years past their expiration date and haven't always been kept in strict climate-controlled conditions may still retain their original potency, a small study suggests."
  February 2019 ,Reuters Health Information,Fluconazole Tied to Miscarriages,"Pregnant women who take oral fluconazole to treat vaginal yeast infections may be more likely to have miscarriages than women who don't take this pill during pregnancy, a Canadian study suggests."
  February 2019 ,Reuters Health Information,Stereotactic Body Radiotherapy Shows Long-Term Safety in Prostate Cancer,"Stereotactic body radiotherapy (SBRT) appears to provide good long-term results and very few toxic effects in certain prostate cancers, according to data from thousands of patients."
  February 2019 ,Medscape Medical News,Five Dermatologic Emergencies Physicians Should Recognize,"These 'are the ones that, if you miss the diagnosis, you end up with a lot more morbidity and mortality than necessary,' an expert says."
  February 2019 ,Kaiser Health News,Americans Going to Mexico to Buy Insulin at Fraction of US Cost,"For one patient, a three-month supply of insulin is $3,700 in the U.S. versus $600 in Mexico. But is it legal?"
  February 2019 ,Reuters Health Information,Mitoxantrone for Childhood Cancer More Cardiotoxic Than Thought,"In pediatric cancer patients, mitoxantrone appears to be at least ten times as cardiotoxic as doxorubicin therapy, while daunorubicin therapy may be less so, according to a large cohort study."
  February 2019 ,Medscape Medical News,"Chemobrain: How It Happens, and Perhaps How It Can Be Stopped",New insights into how chemotherapy affects the brain may lead to ways to treat and maybe even prevent the cognitive impact of cancer drugs.
  April 2019 ,Reuters Health Information,Contrast-Agent Allergies Often Poorly Documented in EHR,"Documentation of contrast-agent allergies in electronic health records (EHRs) often lacks important information, such as the particular agent, according to new research."
  March 2019 ,Reuters Health Information,"Weight Gain, Blood Pressure Rise Seen With JAK Inhibitor Therapy","Pharmacologic inhibition of Janus kinases (JAK) 1 and 2 is associated with significant weight gain and increased systolic blood pressure, according to a review of patients treated with the JAK1/2 inhibitor ruxolitinib."
  March 2019 ,Reuters Health Information,In Pursuit of the Lost Taste of Chocolate,"One of the side-effects of chemotherapy in cancer patients is dysgeusia, an impaired sense of taste that can leave a patient's favorite foods, such as chocolate, with no flavor at all."
  March 2019 ,Reuters Health Information,Amphotericin B Makes Path for Lung Defense in Cystic Fibrosis,"Amphotericin B treatment may be able to restore the infection-fighting properties of the lungs in cystic fibrosis by standing in for a missing or deficient protein channel, studies in pigs and in human lung tissue suggest."
  March 2019 ,Reuters Health Information,Preop Immune-modulating Nutrition Improves Outcomes After GI-cancer Surgery,"Preoperative immune-modulating nutrition (IMN) in patients undergoing surgery for gastrointestinal cancer reduces the risk of infectious complications and shortens hospital stays, according to a new systematic review and meta-analysis."
  March 2019 ,Medscape Medical News,Cannabis-Linked ED Visits: Smoking vs Eating Matters,"Cannabis-related visits to the emergency department spiked in Colorado after marijuana was legalized there, with visits as a result of inhalable use being more frequent than from edible use."
  March 2019 ,Medscape Medical News,Worry After Prostatectomy a Self-fulfilling Prophecy,"Three years after a radical prostatectomy, men with the personality trait of neuroticism scored worse on urinary, bowel, sexual, and hormonal domains."
  March 2019 ,Reuters Health Information,Asthma Medication Use Varies Among Latino Youth,"A new U.S. study of groups of Latino youth with asthma sheds light on potential health disparities. Puerto Rican children were less likely than Mexican kids to use asthma inhalers regularly, researchers found."
  March 2019 ,Medscape Medical News,Severe Adverse Events When Osimertinib Follows Immunotherapy,"Severe immune-related adverse events have been observed when osimrtinib was given after, but not before, immune checkpoint inhibitors in patients with advanced NSCLC."
  March 2019 ,Reuters Health Information,No Survival Benefit for Volatile Anesthesia in Elective CABG Surgery,"In a comparison of gas versus needle, a new pragmatic trial has shown that using a volatile anesthesia agent during elective coronary-artery bypass grafting (CABG) did not produce fewer deaths after one year."
  March 2019 ,Reuters Health Information,Shaving 10 Months Off Treatment Not Inferior Against Rifampin-Resistant TB,"A new study in patients with rifampin-resistant tuberculosis (TB) is providing the first strong evidence that the Bangladesh protocol for treating multidrug-resistant (MDR)-TB, which is used for 9 to 11 months, is not inferior to the standard regimen recommended by the World Health Organization, which requires treatment for 20 months."
  March 2019 ,Reuters Health Information,Persistent Alopecia After Cancer Treatment Tied to Lower Quality of Life,"Persistent chemotherapy-induced alopecia (pCIA) is often more severe than endocrine-induced alopecia after chemotherapy (EIAC), but both conditions are associated with a ""negative emotional effect,"" researchers say."
  March 2019 ,Reuters Health Information,"In HIV Patients, Isoniazid-Rifapentine Combo Dramatically Cuts TB Prophylaxis Therapy","The battery-powered device would be useful in resource-poor countries by allowing women to be screened and then treated immediately by nurses, even when there is no electricity."
  March 2019 ,Medscape Medical News,Portable Thermal Ablation Device for Cervical Precancers,"Most approved medications have inactive ingredients that could cause problems in patients with allergies or sensitivities to those ingredients, researchers found."
  March 2019 ,Medscape Medical News,Inactive Ingredients in Medications Cause Trouble for Some,New Jersey Governor Phil Murphy on Tuesday reached an agreement in principle with Democratic lawmakers for the state to potentially become the second in the country to legalize the recreational use of cannabis though legislation.
  March 2019 ,Reuters Health Information,New Jersey Leaders in Deal to Legalize Recreational Marijuana,"Poor reporting of study details and small numbers of participants make it difficult to assess interventions for urinary incontinence after stroke, authors of a Cochrane review say."
  March 2019 ,Reuters Health Information,No Evidence-Based Guidance for Treating Post-Stroke Urinary Incontinence,"Merck has prevailed in a first lawsuit that claimed switching the formulation of levothyroxine in France caused patients harm; the company still faces further claims, however. "
  March 2019 ,Medscape Medical News,Merck Wins Lawsuit on Levothyroxine Saga in France ,"In a radiation-proof room at the Erasmus Medical Center in Rotterdam, Emar Thomasa sits behind shielded glass as he carefully measures and mixes lutetium octreotate, an intravenous treatment for certain types of cancer."
  March 2019 ,Reuters Health Information,Dutch Join Backlash at Expensive Drugs by Making Their Own,"Allergan Plc said on Wednesday its experimental add-on treatment for depression failed three late-stage studies, casting doubts over its drugs pipeline."
  April 2019 ,Reuters Health Information,Teva Scraps Cluster Headache Program,"Teva Pharmaceutical Industries Ltd said on Tuesday it would stop developing its migraine drug, Ajovy, for treating cluster headaches."
  April 2019 ,Reuters Health Information,Research Needed on Long-Term Osteoporosis Drug Therapies,"A variety of drugs are effective for preventing osteoporotic fractures, but there are gaps in the evidence supporting their safety and effectiveness beyond three years, according to a National Institutes of Health Pathways to Prevention Workshop."
  April 2019 ,Reuters Health Information,Reporting of Adverse Drug Reactions Differs by Gender,"Reported adverse reactions to specific drugs show distinct gender differences, new findings show."
  April 2019 ,Reuters Health Information,"Rapid Initiation of Single-Tablet, Quadruple Anti-HIV Therapy Effective","A high proportion of patients with newly diagnosed HIV-1 infection achieved an undetectable viral load through 48 weeks after starting Symtuza (Janssen) within two weeks of diagnosis, according to new data from the DIAMOND study."
  April 2019 ,Medscape Medical News,Risky AEDs Still Prescribed to Women of Childbearing Age,"Despite warnings that use of certain antiepileptic drugs (AEDs) during pregnancy carry significant risks for poor outcomes in children, the drugs are still being used at concerning levels."
  April 2019 ,Reuters Health Information,Hyponatremia Linked to Metabolic Bone Disease in Epilepsy,"In patients with epilepsy, hyponatremia - a common side effect of several antiepileptic drugs (AEDs) - is independently associated with decreased bone-mineral density (BMD) and an increased risk of osteoporosis, researchers from Denmark report."
  April 2019 ,Reuters Health Information,Emergency-Medicine Residents Often Miscalculate IV Doses for Kids,"Emergency-medicine residents often miscalculate doses for a variety of intravenous medications used to treat children, according to new findings."
  April 2019 ,Medscape Medical News,More Evidence Schizophrenia Combo Therapy Blunts Weight Gain,"The combination of olanzapine and samidorphan, shown to mitigate the weight gain observed with olanzapine alone in ENLIGHTEN-2, continues to prevent weight gain, new results from an extension study show."
  April 2019 ,Reuters Health Information,"U.S. Charges Pummel Drugmaker Indivior, Hurt Reckitt",Indivior Plc lost three-quarters of its stock market value on Wednesday and former parent Reckitt Benckiser also fell after the U.S. Justice Department accused the British drugmaker of illegally boosting prescriptions for its blockbuster opioid addiction treatment.
  April 2019 ,Reuters Health Information,"Targeted Drug Delivery for Cancer Pain Cuts Costs, Hospital Time","Targeted drug delivery (TDD) reduces costs and healthcare utilization when added to conventional medical management (CMM) for patients with cancer-related pain, according to new findings."
  April 2019 ,Reuters Health Information,Zogenix's Seizure Drug Filing Fails to Pass U.S. FDA Scrutiny,"The U.S. Food and Drug Administration on Monday refused to fully review the marketing application for Zogenix Inc's treatment for seizures associated with Dravet syndrome, a rare form of childhood epilepsy."
  April 2019 ,Reuters Health Information,Ribaxamase Reduces C. Diff Infection After Beta-Lactam Therapy,"The beta-lactamase ribaxamase reduces the incidence of Clostridium difficile infections in hospitalized patients treated with intravenous ceftriaxone for lower-respiratory-tract infections, researchers report."
  April 2019 ,Medscape Medical News,FDA Clears New Drug-Sparing Option for HIV Infection,"The dolutegravir and lamivudine combination (Dovato) is the first once-daily, single-tablet, two-drug regimen for adults with treatment-naive HIV infection."
  April 2019 ,Reuters Health Information,"For Psoriasis, Ustekinumab and TNF Inhibitors Show Similar Cardiac Safety","In patients with psoriatic disease, the incidence of atrial fibrillation (AF) and major adverse cardiovascular events (MACE) does not differ between treatment with ustekinumab and TNF inhibitors, according to a large observational study."
  April 2019 ,News Alerts,"FDA Warns Lab Against Marketing Tests Linking Genes, Drug Reaction",Inova Genomics is cited for illegally marketing MediMap genetic tests that claim to predict a patient's response to antidepressants and other medications.
  April 2019 ,Reuters Health Information,Umbralisib Shows Promise in Relapsed/Refractory Marginal Zone Lymphoma,"Umbralisib, an investigational oral inhibitor of PI3K-delta, has significant activity against relapsed/refractory marginal-zone lymphoma (MZL) and manageable side effects, according to early results from an ongoing phase 2b trial."
  April 2019 ,Reuters Health Information,Lenalidomide Plus Rituximab Ups Response in Relapsed Indolent Lymphoma,"In patients with relapsed or refractory indolent non-Hodgkin lymphoma, adding lenalidomide to rituximab improves response, according to a placebo-controlled trial."
  April 2019 ,Medscape Medical News,"Persons Living With Incurable Cancer a Growing, Neglected Group","Through advances in treatment, an ever-increasing number of people are living with metastatic cancer, presenting a host of challenges that require increased attention."
  April 2019 ,Reuters Health Information,Topical PDE4 Inhibitors Suitable for Mild-to-Moderate Atopic Dermatitis,"Topical phosphodiesterase 4 (PDE4) inhibitors are safe and effective for the treatment of mild-to-moderate atopic dermatitis, researchers in China have found."
  April 2019 ,Reuters Health Information,Preventive Drugs Could Be Safely Discontinued in Elderly With Advanced Cancer,"Many preventive drugs could be safely discontinued, with substantial cost savings, in the last year of life of older adults with cancer, according to a retrospective study of Swedish data."
  May 2019 ,Reuters Health Information,Sexual Function and Intimacy Impaired in Inflammatory Arthritis,"Patients with inflammatory arthritis (IA) report significant impairments in sexual function and intimate relationships, researchers from Australia report."
  May 2019 ,Reuters Health Information,"Add-On Sotagliflozin Has Benefits, Raises Ketoacidosis Risk in Type 1 Diabetes","Add-on dual sodium-glucose cotransporter (SGLT) 1/2 inhibitor sotagliflozin has benefits in patients with type 1 diabetes, according to a new meta-analysis."
  May 2019 ,Reuters Health Information,Skin Testing Helpful in Patients With Radiocontrast-Media Hypersensitivity,"Skin testing can be used to differentiate allergy from non-allergic reactions in patients with hypersensitivity to radiocontrast media (RCM) and to identify an alternative, safe RCM, researchers from Germany report."
  May 2019 ,Medscape Medical News,"Medical Cannabis Safe, Effective in the Elderly","Researchers reported that the drug provided relief from chronic pain, sleep disorders, and anxiety related to a variety of diseases."
  May 2019 ,Reuters Health Information,Oral Fluoroquinolones Carry Small Risk of Peripheral Neuropathy,"Oral fluoroquinolone exposure is associated with a small increase in risk of peripheral neuropathy, according to findings from The Health Improvement Network (THIN) database."
  May 2019 ,Medscape Medical News,No Edge for Levetiracetam Over Phenytoin for Status Epilepticus,"Both levetiracetam and phenytoin are reasonable second-line treatment options for pediatric status epilepticus, new research shows."
  May 2019 ,Medscape Medical News,Watchful Waiting OK in Diabetic Macular Edema With Good Vision,"New trial suggests no difference in risk for vision loss over 2 years with aflibercept, laser treatment, or observation; experts stress importance of adherence to follow-up and tight glycemic control."
  May 2019 ,Reuters Health Information,Adverse Events Common With PD-1 and PD-L1 Inhibitors,"Most cancer patients treated with programmed cell death (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors experience at least one treatment-related adverse event, according to a new systematic review and meta-analysis."
  May 2019 ,Reuters Health Information,Longer Course of Solifenacin Does Not Reduce Overactive Bladder Recurrence,"Prolonged anti-muscarinic treatment with solifenacin does not decrease the risk for retreatment of overactive bladder, researchers say."
  May 2019 ,Reuters Health Information,"Bb2121 CAR-T Multiple Myeloma Treatment Effective, but Benefits May Wane","Doctors testing a chimeric antigen receptor T-cell (CAR-T) therapy against relapsed or refractory multiple myeloma say results from 33 patients show a complete response rate of 45%, although 40% of those patients with a complete response ultimately relapsed."
  May 2019 ,Reuters Health Information,Long-Term Methimazole Treatment Benefits Children With Graves' Disease,"Continuation of methimazole treatment beyond 24 months is associated with significantly higher cure rates in patients with Graves' hyperthyroidism, researchers from Iran report."
  May 2019 ,Reuters Health Information,Higher Colony-Count Threshold for Urinary Pathogens Cuts Antimicrobial Treatment,"Raising the colony-count threshold for treatment of urinary pathogens in hospitalized patients is associated with reduced antimicrobial use, researchers report."
  May 2019 ,FDA Approvals,"FDA Approves First Vaccine for Dengue, With Restrictions",Dengvaxia is for the prevention of dengue disease caused by all dengue virus serotypes in people aged 9 to 16 years who have previously had laboratory-confirmed dengue infection and who live in endemic areas.
  April 2019 ,Reuters Health Information,Pentosan Polysulfate Sodium Treatment Strongly Linked With Maculopathy and Vision Loss,"Patients taking pentosan polysulfate sodium (PPS), which has been on the market for many years, appear to be at greater risk for a newly described maculopathy and vision loss, researchers report."
  April 2019 ,Reuters Health Information,Immune-Checkpoint-Blockade Toxicity Often Missed in Emergency Departments,"Emergency medicine physicians commonly miss immune-related adverse events (IRAEs) stemming from immune-checkpoint blockade in patients with cancer, according to a new study from France."
  April 2019 ,Reuters Health Information,Peanut Oral Immunotherapy Safe for Preschoolers in Real-World,"Oral immunotherapy for peanut allergy is safe in preschool-aged children when given as routine treatment in a hospital or clinic, a new study has found."
  April 2019 ,Medscape Medical News,Regulators Uneven on Safety Warnings on New Drugs,"FDA ranks third among health authorities in four English-speaking countries in the frequency of postmarketing drug safety warnings, new data show."
  April 2019 ,Reuters Health Information,Adverse Skin Effects Tied to Anti-PD1 Response in Melanoma,"Cutaneous toxic effects (CT) following treatment with anti-programmed-cell-death 1 (anti-PD-1) inhibitors may be encouraging news in patients with advanced melanoma, a retrospective review suggests."
  April 2019 ,Medscape Medical News,"Novel CAR T-Cell Approach Reduces Toxicities, Retains Efficacy",The modified molecule for the anti-CD19 CAR T-cell therapy shows signs of reducing the risk for severe cytokine release syndrome while maintaining efficacy.
  April 2019 ,Reuters Health Information,Albuterol Before Tonsillectomy Protects Against Respiratory Problems,"Preoperative inhaled albuterol can help protect against perioperative respiratory adverse events in young children undergoing anesthesia for tonsillectomy, according to data from the Australian REACT trial."
  June 2019 ,Reuters Health Information,"Aquablation Shows ""Promising"" Outcomes in BPH Patients With Large Prostates","Aquablation appears to effectively and safely treat benign prostatic hyperplasia (BPH) in prostates of up to 150 cc, an industry-funded study suggests."
  June 2019 ,Reuters Health Information,"Young Adults See Less Harm in Tobacco Products, Prefer Online Health Information","Young adults may be more likely than older folks to go online to find health information, and less likely to view tobacco products as ""very harmful,"" according to survey results compiled to inform U.S. Food and Drug Administration (FDA) regulatory policy."
  June 2019 ,Reuters Health Information,Bictegravir-Based Regimen Noninferior to Dolutegravir-Based Regimens for HIV Treatment,"A single-tablet regimen of bictegravir, emtricitabine and tenofovir alafenamide is noninferior to regimens of dolutegravir coformulated with emtricitabine and tenofovir alafenamide or with abacavir and lamivudine for the initial treatment of HIV-1 infection, according to results from two randomized phase 3 trials."
  June 2019 ,Reuters Health Information,"Previous Seasons' Flu Shots Protective, Less So for Elders","Influenza vaccines given in previous seasons still provide some protection against infection, according to a new study."
  June 2019 ,Medscape Medical News,"'Scary World' of Generic Drug Manufacturing, Revealed",Doctors noticed problems with the generic drugs their patients took and helped investigative reporter Katherine Eban bring to light systemic issues with the drugs' manufacturing and regulation. 
  June 2019 ,Medscape Medical News,Less Toxicity With Proton Beam vs Photon Chemoradiotherapy ,"Survival outcomes were similar compared with traditional photon chemoradiotherapy, but patients treated with proton beam therapy had significantly fewer serious adverse events."
  June 2019 ,Reuters Health Information,Serial-Killer Nurse Jailed for Life in Germany,A former nurse was jailed for life on Thursday for murdering 85 of his patients - the worst killing spree in Germany's post-war history.
  June 2019 ,Reuters Health Information,Pembrolizumab an Alternative to Chemo in Some Advanced Stomach Cancers,"For patients with PD-L1-positive, HER2-negative, advanced gastric or gastroesophageal junction (G/GEJ) cancer, front-line treatment with pembrolizumab is noninferior to standard chemotherapy and far less toxic, according to results of the KEYNOTE-062 trial."
  June 2019 ,Reuters Health Information,Amgen Drug Shows High Response Rate in Small Lung and Colon Cancer Trial,"An experimental Amgen Inc drug that targets a specific genetic mutation significantly reduced tumor size in half of evaluated patients with advanced lung cancer in a small, early-stage trial, researchers said on Monday."
  June 2019 ,Medscape Medical News,Ketamine May Help Teens With Resistant Depression,"Ketamine produced a significant reduction of depressive symptoms in teens with treatment-resistant depression in this first RCT, but its effects on the developing brain need to be rigorously explored."
  May 2019 ,Reuters Health Information,Methylphenidate Dose Titration in ADHD Should Be Based on Outcomes,"Dose titration of methylphenidate in patients with attention-deficit/hyperactivity disorder (ADHD) should aim to maximize the ratio of benefit to adverse effects, as there appears to be no scientific rationale for published maximum doses, according to a meta-analysis."
  May 2019 ,Medscape Medical News,"Botox May Help Bipolar Depression, Social Anxiety","In two small case series, injections of botulinum toxin into the glabellar region -- the area between the eyebrows and above the nose -- reduced symptoms of bipolar depression and social anxiety."
  May 2019 ,Medscape Medical News,"Antipsychotic Side Effects Tough to Take, Patients Say",Patients with schizophrenia who take second-generation antipsychotics often suffer side effects that significantly disrupt daily functioning and quality of life.
  May 2019 ,Reuters Health Information,New Regional Dermatoses Can Develop During Dupilumab Treatment,"Dupilumab treatment of atopic dermatitis can be accompanied by the emergence of new regional dermatoses, according to a retrospective study."
  May 2019 ,Reuters Health Information,Some Systemic Psoriasis Drugs May Carry Lower Risk of Serious Infection,"Psoriasis patients who start treatment with apremilast, etanercept or ustekinumab have a lower risk of developing a serious infection than those prescribed methotrexate, new findings show."
  May 2019 ,Medscape Medical News,Targeting Vasopressin May Improve Social Deficits in Autism,"There are currently no medications to address social deficits in autism, but two new studies suggest that vasopressin, a hormone associated with social bonding, may be a viable target for drug development."
  May 2019 ,News Alerts,EU Panel Backs Market Withdrawal of Fenspiride Due to Heart Risk,"The European Medicines Agency's Pharmacovigilance Risk Assessment Committee recommended revoking marketing authorizations for fenspiride medicines, preventing them from being marketed in the EU."
  May 2019 ,Medscape Medical News,Alpelisib Nearly Doubles PFS in PIK3-Mutated Breast Cancer,A novel PIK3 inhibitor combined with fulvestrant nearly doubled progression- free survival (PFS) in PIK3CA-mutated breast cancer.
  May 2019 ,Reuters Health Information,Worse Prostate Cancer Outcomes With 5-Alpha-Reductase Inhibitors,"Treatment with 5-alpha-reductase inhibitors (5-ARIs) is associated with shorter time to diagnosis and worse mortality in prostate cancer, according to findings from Veterans Affairs electronic health records."
  May 2019 ,Reuters Health Information,Radiation Therapy Consent Forms Too Difficult to Read,"Cancer patients usually get written consent forms to sign before radiation that are supposed to clearly spell out the treatment risks, but a new U.S. study suggests these forms are too complex for most patients to easily understand."