diff --git a/packages/e2e-tests/experimental-features.js b/packages/e2e-tests/experimental-features.js
index 0976b2c4086037..8e649d3781ae94 100644
--- a/packages/e2e-tests/experimental-features.js
+++ b/packages/e2e-tests/experimental-features.js
@@ -157,4 +157,17 @@ export const siteEditor = {
 			return '';
 		} );
 	},
+
+	async disableWelcomeGuide() {
+		const isWelcomeGuideActive = await page.evaluate( () =>
+			wp.data.select( 'core/edit-site' ).isFeatureActive( 'welcomeGuide' )
+		);
+		if ( isWelcomeGuideActive ) {
+			await page.evaluate( () =>
+				wp.data
+					.dispatch( 'core/edit-site' )
+					.toggleFeature( 'welcomeGuide' )
+			);
+		}
+	},
 };
diff --git a/packages/e2e-tests/specs/experiments/document-settings.test.js b/packages/e2e-tests/specs/experiments/document-settings.test.js
index c3a13c75abb102..0d764a3e3dda34 100644
--- a/packages/e2e-tests/specs/experiments/document-settings.test.js
+++ b/packages/e2e-tests/specs/experiments/document-settings.test.js
@@ -36,6 +36,7 @@ describe( 'Document Settings', () => {
 
 	beforeEach( async () => {
 		await siteEditor.visit();
+		await siteEditor.disableWelcomeGuide();
 	} );
 
 	describe( 'when a template is selected from the navigation sidebar', () => {
diff --git a/packages/e2e-tests/specs/experiments/multi-entity-editing.test.js b/packages/e2e-tests/specs/experiments/multi-entity-editing.test.js
index c2090e340f39cf..8d8a6ac7e4fc7d 100644
--- a/packages/e2e-tests/specs/experiments/multi-entity-editing.test.js
+++ b/packages/e2e-tests/specs/experiments/multi-entity-editing.test.js
@@ -145,6 +145,7 @@ describe( 'Multi-entity editor states', () => {
 
 	it( 'should not display any dirty entities when loading the site editor', async () => {
 		await siteEditor.visit();
+		await siteEditor.disableWelcomeGuide();
 		expect( await openEntitySavePanel() ).toBe( false );
 	} );
 
@@ -204,6 +205,7 @@ describe( 'Multi-entity editor states', () => {
 			);
 			await saveAllEntities();
 			await siteEditor.visit();
+			await siteEditor.disableWelcomeGuide();
 
 			// Wait for site editor to load.
 			await canvas().waitForSelector(
diff --git a/packages/e2e-tests/specs/experiments/settings-sidebar.test.js b/packages/e2e-tests/specs/experiments/settings-sidebar.test.js
index be3e44fce32b47..d36bc9bc092250 100644
--- a/packages/e2e-tests/specs/experiments/settings-sidebar.test.js
+++ b/packages/e2e-tests/specs/experiments/settings-sidebar.test.js
@@ -53,6 +53,7 @@ describe( 'Settings sidebar', () => {
 	} );
 	beforeEach( async () => {
 		await siteEditor.visit();
+		await siteEditor.disableWelcomeGuide();
 	} );
 
 	describe( 'Template tab', () => {
diff --git a/packages/e2e-tests/specs/experiments/site-editor-export.test.js b/packages/e2e-tests/specs/experiments/site-editor-export.test.js
index 961a19525c6a23..b534509de4b006 100644
--- a/packages/e2e-tests/specs/experiments/site-editor-export.test.js
+++ b/packages/e2e-tests/specs/experiments/site-editor-export.test.js
@@ -41,6 +41,7 @@ describe( 'Site Editor Templates Export', () => {
 
 	beforeEach( async () => {
 		await siteEditor.visit();
+		await siteEditor.disableWelcomeGuide();
 	} );
 
 	it( 'clicking export should download edit-site-export.zip file', async () => {
diff --git a/packages/e2e-tests/specs/experiments/site-editor-inserter.test.js b/packages/e2e-tests/specs/experiments/site-editor-inserter.test.js
index 3aa7d649f86ef1..fab65066206a3f 100644
--- a/packages/e2e-tests/specs/experiments/site-editor-inserter.test.js
+++ b/packages/e2e-tests/specs/experiments/site-editor-inserter.test.js
@@ -19,6 +19,7 @@ describe( 'Site Editor Inserter', () => {
 	} );
 	beforeEach( async () => {
 		await siteEditor.visit();
+		await siteEditor.disableWelcomeGuide();
 	} );
 
 	it( 'inserter toggle button should toggle global inserter', async () => {
diff --git a/packages/e2e-tests/specs/experiments/template-part.test.js b/packages/e2e-tests/specs/experiments/template-part.test.js
index ddec6e7d362018..8f18da2b88006e 100644
--- a/packages/e2e-tests/specs/experiments/template-part.test.js
+++ b/packages/e2e-tests/specs/experiments/template-part.test.js
@@ -36,6 +36,7 @@ describe( 'Template Part', () => {
 	describe( 'Template part block', () => {
 		beforeEach( async () => {
 			await siteEditor.visit();
+			await siteEditor.disableWelcomeGuide();
 		} );
 
 		async function navigateToHeader() {
diff --git a/packages/e2e-tests/specs/experiments/template-revert.test.js b/packages/e2e-tests/specs/experiments/template-revert.test.js
index 67a167728cbdd9..771578215ca701 100644
--- a/packages/e2e-tests/specs/experiments/template-revert.test.js
+++ b/packages/e2e-tests/specs/experiments/template-revert.test.js
@@ -16,7 +16,11 @@ import { addQueryArgs } from '@wordpress/url';
  */
 import { siteEditor } from '../../experimental-features';
 
-const { visit: visitSiteEditor, getEditedPostContent } = siteEditor;
+const {
+	visit: visitSiteEditor,
+	getEditedPostContent,
+	disableWelcomeGuide,
+} = siteEditor;
 
 const assertSaveButtonIsDisabled = () =>
 	page.waitForSelector(
@@ -97,6 +101,7 @@ describe( 'Template Revert', () => {
 	beforeEach( async () => {
 		await trashAllPosts( 'wp_template' );
 		await visitSiteEditor();
+		await disableWelcomeGuide();
 	} );
 
 	it( 'should delete the template after saving the reverted template', async () => {